Alzheimer's Disease Ontology (ADO)
type: Ontology
version IRI: ado.owl
version info: 2.0.1
creator: Astghik Sargsyan
creator: Bide Zhang
creator: Philipp Wegner
creator: Stephan Gebel
license: https://creativecommons.org/licenses/by/4.0/
creator: Vanessa Lage-Rupprecht
creator: Alpha Tom Kodamullil
description: Alzheimer's Disease Ontology is a knowledge-based ontology that encompasses varieties of concepts related to Alzheimer'S Disease, foundamentally structured by upper level Basic Formal Ontology(BFO). This Ontology is enriched by the interrelational entities that demonstrate the nextwork of the understanding on Alzheimer's disease and can be readily applied for text mining.

BFO OWL specification label
type: AnnotationProperty
definition: Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification.
curator note: Really of interest to developers only
sub property of: label

BFO CLIF specification label
type: AnnotationProperty
definition: Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2
definition source: Person:Alan Ruttenberg
curator note: Really of interest to developers only
sub property of: label

细胞系LINCS ID
type: AnnotationProperty
definition: An annotation property that represents an ID used in the NIH LINCS project.
definition: An annotation property that represents an LINCS ID of a cell line.
definition: 表示细胞系的LINCS ID的注释属性。
definition editor: Oliver He, Jiangan Xie
definition editor: Oliver He, Jiangan Xie, Jie Zheng
label: Cell line LINCS ID
label: LINCS ID

has_RxCUI
type: AnnotationProperty

IHCC category
type: AnnotationProperty

IHCC browser label
type: AnnotationProperty

editor preferred label
type: AnnotationProperty
editor preferred label: editor preferred label
editor preferred label: editor preferred term
editor preferred label: editor preferred term~editor preferred label
editor preferred label: 编辑首选术语 @zh
editor preferred label: 编辑首选标签 @zh
has curation status: IAO_0000122
definition: The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
definition: 对于一类或属性的简洁的、有意义的、与人类友好的名称由本体开发商首选。 （美国英语） @zh
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: editor preferred term
label: editor preferred term~editor preferred label
label: 编辑首选术语
label: 编辑首选术语~编辑首选标签
label: 编辑首选标签

example of usage
type: AnnotationProperty
editor preferred label: example
editor preferred label: example of usage
has curation status: IAO_0000122
definition: A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not
definition: A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
database cross reference: IAO:0000112
has_obo_namespace: uberon
id: example_of_usage
is metadata tag: true
shorthand: example_of_usage

has curation status
type: AnnotationProperty
editor preferred label: has curation status
editor preferred label: 有管理状态 @zh
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Bill Bug
definition editor: PERSON:Melanie Courtot
definition source: OBI_0000281
label: 有管理状态

definition
type: AnnotationProperty
editor preferred label: definition
editor preferred label: textual definition
editor preferred label: 定义 @zh
has curation status: IAO_0000122
definition: A property representing the English language definitions of what NCI means by the concept. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.
definition: English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.
definition: OBI的官方定义，解释类或属性的含义。应该是亚里士多德式的，形式化和规范化的。 可以通过口语定义进行扩充。 @zh
definition: The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
definition: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
definition: 官方的定义，解释类或属性的含义。应该是亚里士多德式的，形式化和规范化的。 可以通过口语定义进行扩充。 @zh
editor note: 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
editor note: 2012-04-05: Barry Smith OBI的官方定义解释了一个类或属性的含义：'应该是亚里士多德式的，形式化和规范化的。可以用口语定义'是糟糕的。 您能解决这样的问题吗？ 解释关于类或属性的表达含义的必要和充分条件的陈述。 Alan Ruttenberg 您提出的定义是一个合理的备选，除非它很常见，没有给出必要和充分的条件。大多数情况下它们是必要的，偶尔是必要的，充分的或者仅仅仅充分的。它们通常使用不是自己定义的术语，因此它们实际上不能通过这些标准进行评估。 关于拟议定义的具体内容： 我们没有“含义”，或“表达”或“属性”的定义。对于在预期意义上的“参考”，我认为我们使用术语“指示”。对于'表达'，我认为我们和你的意思是符号，或标识符。对于“含义”，它不同于类和属性。对于类，我们希望文档能够让读者确定一个实体是否是该类的实例。对于属性，让我们的目标读者决定，给定一对潜在的关系，判断关系成立的断言正确与否。 “目标读者”部分表明我们也指定了我们期望的能够理解定义的人，并且概括了人类和计算机读者以包含文本和逻辑定义。 就我个人而言，我更愿意削弱对文档的定义，并指出什么是可取的。 我们还有一个悬而未决的问题，就是如何针对不同的受众定位不同的定义。临床读者阅读chebi需要来自受过化学训练的受众的不同类型的定义文档/定义，同样需要一个适合本体工作者的定义。
definition editor: PERSON:Daniel Schober
alternative term: DEFINITION
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
description adapted from source: no
has exact synonym: DEFINITION
label: textual definition
label: 定义
label: 文本定义

editor note
type: AnnotationProperty
editor preferred label: editor note
editor preferred label: 编者注 @zh
has curation status: IAO_0000122
definition: An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
definition: 管理者注释用于其编辑器。它可能不包含在本体的出版版本中，所以它应该不包含最终用户了解本体所需的信息。 @zh
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
definition source: GROUP:OBI:<http://purl.obofoundry.org/obo/obi>
has db xref: IAO:0000116
has OBO namespace: uberon
id: editor_note
id: 编辑_注释 @zh
is metadata tag: true
shorthand: editor_note
shorthand: 编辑_注释 @zh
database cross reference: IAO:0000116
has_obo_namespace: uberon
is metadata tag: 1
label: 编者注

definition editor
type: AnnotationProperty
editor preferred label: definition editor
editor preferred label: term editor
editor preferred label: 术语编辑者 @zh
has curation status: IAO_0000122
definition: Name of editor entering the definition in the file. The definition editor is a point of contact for information regarding the term. The definition editor may be, but is not always, the author of the definition, which may have been worked upon by several people
definition: Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
definition: 输入文件中术语编辑者的名称。术语编辑者是有关术语的信息交汇点。术语编辑者可以是，但并不总是，定义的作者，这可能是由几个人完成 @zh
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115.
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115.
editor note: 20110707，MC：术语编辑和定义进行相应的修改。见http://code.google.com/p/information-artifact-ontology/issues/detail?id=115。 @zh
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: definition_editor
label: term editor
label: 术语编辑者

alternative term
type: AnnotationProperty
editor preferred label: alternative term
editor preferred label: 替代术语 @zh
has curation status: IAO_0000125
definition: An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)
definition: 一类或属性的替代名称，这意味着与所述首选名称同样的事物（语义上等价） @zh
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: 替代术语

definition source
type: AnnotationProperty
editor preferred label: definition source
editor preferred label: 定义来源 @zh
has curation status: IAO_0000122
definition: Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
definition: formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
definition: 正式引用，例如在外部数据库中的标识符，用于表示/定义的属性源（S）。自由文本表示/为定义属性源（S）。实例：在2007年1月31日的作者姓名，URI，MeSH术语C04，PUBMEDID，维基uri @zh
definition editor: PERSON:Daniel Schober
definition source: Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
definition source: 论OBO-讨论邮件-列表，请参阅http://bit.ly/hgm99w @zh
label: definition_source
label: 定义来源

curator note
type: AnnotationProperty
editor preferred label: curator note
has curation status: IAO_0000122
definition: An administrative note of use for a curator but of no use for a user
definition editor: PERSON:Alan Ruttenberg
database cross reference: IAO:0000232
has_obo_namespace: uberon
id: curator_notes
is metadata tag: 1
is metadata tag: true
shorthand: curator_notes
label: curator notes

term tracker item
type: AnnotationProperty
database cross reference: IAO:0000233
has_obo_namespace: external
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item

imported from
type: AnnotationProperty
editor preferred label: imported from
editor preferred label: 引自 @zh
has curation status: IAO_0000125
definition: For external terms/classes, the ontology from which the term was imported
definition: 外部术语/类，术语引入的本体 @zh
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Melanie Courtot
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: 引自

expand assertion to
type: AnnotationProperty

OBO foundry unique label
type: AnnotationProperty
editor preferred label: OBO foundry unique label
has curation status: IAO_0000125
definition: An alternative name for a class or property which is unique across the OBO Foundry.
editor note: The intended usage of that property is as follow: OBO foundry unique labels are automatically generated based on regular expressions provided by each ontology, so that SO could specify unique label = 'sequence ' + [label], etc. , MA could specify 'mouse + [label]' etc. Upon importing terms, ontology developers can choose to use the 'OBO foundry unique label' for an imported term or not. The same applies to tools .
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Bjoern Peters
definition editor: PERSON:Chris Mungall
definition editor: PERSON:Melanie Courtot
definition source: GROUP:OBO Foundry <http://obofoundry.org/>

elucidation
type: AnnotationProperty
editor preferred label: elucidation
definition editor: person:Alan Ruttenberg
definition source: Person:Barry Smith
elucidation: Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms

has associated axiom(nl)
type: AnnotationProperty
editor preferred label: has associated axiom(nl)
definition editor: Person:Alan Ruttenberg
definition source: Person:Alan Ruttenberg
elucidation: An axiom associated with a term expressed using natural language

has associated axiom(fol)
type: AnnotationProperty
editor preferred label: has associated axiom(fol)
definition editor: Person:Alan Ruttenberg
definition source: Person:Alan Ruttenberg
elucidation: An axiom expressed in first order logic using CLIF syntax

RUBRIC
type: AnnotationProperty
definition editor: Cooper Stansbury
curator note: This annotation property specifies classes that were developed as part of an alignment effort between the Common Rule Ontology and the Informed Consent Ontology in the Summer of 2018. These classes represent entities that are necessary for understanding the regularatory frameworks that influence informed consent, often at a different level of granularity than individual consent processes. These classes were created to be compatible with regulatory frameworks outside the Unitied States, hence they are general.

has literature mining keywords
type: AnnotationProperty
definition: an annotation property that lists keyword(s) useful for literature tagging and retrieval of sentences containing the type (or kind) of entity (e.g., interaction) as shown by the ontology term label and definition.
definition editor: Yongqun He

has keyword dependency pattern
type: AnnotationProperty
definition: an annotation property that specifies the dependency pattern of the literature keywords that match to the ontology interaction type.
definition editor: Arzucan Ozgur, Junguk Hur, Yongqun He

Has_NICHD_Parent
type: AnnotationProperty
definition: An association created to allow the source NICHD to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are a contributing source.
code: A11
Semantic_Type: Conceptual Entity
Preferred_Name: Has_NICHD_Parent
has exact synonym: Has_NICHD_Parent

Related_To_Genetic_Biomarker
type: AnnotationProperty
definition: An association that indicates that a finding or lab test is related to a gene, possibly through a variant or product.
code: A13
Semantic_Type: Conceptual Entity
Preferred_Name: Related_To_Genetic_Biomarker
has exact synonym: Related_To_Genetic_Biomarker

Is_PCDC_AML_Permissible_Value_For_Variable
type: AnnotationProperty
definition: An association that indicates a PCDC AML concept is a Permissible Value for a PCDC AML Variable concept.
code: A24
Semantic_Type: Conceptual Entity
Preferred_Name: Is_PCDC_AML_Permissible_Value_For_Variable
has exact synonym: Is_PCDC_AML_Permissible_Value_For_Variable

Is_PCDC_EWS_Permissible_Value_For_Variable
type: AnnotationProperty
definition: An association that indicates a PCDC EWS concept is a Permissible Value for a specific PCDC EWS Variable concept.
code: A28
Semantic_Type: Conceptual Entity
Preferred_Name: Is_PCDC_EWS_Permissible_Value_For_Variable
has exact synonym: Is_PCDC_EWS_Permissible_Value_For_Variable

code
type: AnnotationProperty
read only: true
definition: A property representing a concept unique identifier within the NCI Enterprise Vocabulary Service's NCI Thesaurus.
code: NHC0
Semantic_Type: Conceptual Entity
Preferred_Name: code
has exact synonym: code

OMIM_Number
type: AnnotationProperty
definition: A property representing the accession number for a Protein or Gene within the OMIM database.
code: P100
Semantic_Type: Conceptual Entity
Display_Name: OMIM Number
Preferred_Name: OMIM_Number
has exact synonym: OMIM_Number

Semantic_Type
type: AnnotationProperty
definition: A property that represents a description of the sort of thing or category to which a concept belongs in the context of the UMLS semantic network.
definition: The semantic type describes the sort of thing or category to which a concept belongs in the context of the UMLS semantic network.
code: P106
Semantic_Type: Conceptual Entity
Display_Name: Semantic Type
Preferred_Name: Semantic_Type
DesignNote: In general, applying semantic types aids in allowing users (or computer programs) to draw conclusions about concepts by virtue of the categories to which they have been assigned. We use a set of semantic types developed for the UMLS Metathesaurus. There are currently 134 semantic types in the UMLS.
has exact synonym: Semantic_Type

Display_Name
type: AnnotationProperty
definition: A property representing an alternative Preferred Name for use in some NCI systems.
definition: Provides an alternative Preferred Name for use in some NCI systems.
code: P107
Semantic_Type: Conceptual Entity
Display_Name: Display Name
Preferred_Name: Display_Name
has exact synonym: Display Name
has exact synonym: Display_Name

Preferred_Name
type: AnnotationProperty
definition: A property representing the word or phrase that NCI uses by preference to refer to the concept.
definition: The word or phrase that NCI uses by preference to refer to the concept.
code: P108
Semantic_Type: Conceptual Entity
Display_Name: Preferred Name
Preferred_Name: Preferred_Name
has exact synonym: Preferred Name
has exact synonym: Preferred Term
has exact synonym: Preferred_Name

UMLS_CUI
type: AnnotationProperty
definition: A property representing the concept unique identifier (CUI) assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept.
definition: Concept Unique Identifiers, or CUIs, are concept numbers assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept.
code: P207
Semantic_Type: Conceptual Entity
Display_Name: UMLS CUI
Preferred_Name: UMLS_CUI
has exact synonym: UMLS_CUI

NCI_META_CUI
type: AnnotationProperty
definition: A property representing the concept unique identifier (CUI) for those concepts that appear in NCI Metathesaurus but not in the National Library of Medicine Unified Medical Language System (NLM UMLS).
code: P208
Semantic_Type: Conceptual Entity
Display_Name: NCI Metathesaurus CUI
Preferred_Name: NCI_META_CUI
has exact synonym: NCI_META_CUI

CAS_Registry
type: AnnotationProperty
definition: A property representing the Chemical Abstracts Service number for a Chemical or Drug.
code: P210
Semantic_Type: Conceptual Entity
Display_Name: CAS Registry Number
Preferred_Name: CAS_Registry
has exact synonym: CAS_Registry

KEGG_ID
type: AnnotationProperty
definition: A property representing the KEGG ID code for a pathway. It can be used to link a KEGG pathway reference to the primary pathway information.
code: P215
Semantic_Type: Conceptual Entity
Display_Name: KEGG ID
Preferred_Name: KEGG_ID
has exact synonym: KEGG_ID

Accepted_Therapeutic_Use_For
type: AnnotationProperty
definition: A property representing a disease or condition for which this drug is an accepted treatment. Used in the Drug, Food, Chemical or Biomedical Material branch.
code: P302
Semantic_Type: Conceptual Entity
Display_Name: Accepted Therapeutic Use For
Preferred_Name: Accepted_Therapeutic_Use_For
has exact synonym: Accepted_Therapeutic_Use_For

Concept_Status
type: AnnotationProperty
definition: A property used to indicate the standing of a concept in relation to currently accepted classifications and concepts. In NCI Thesaurus concept status subtype indicates concepts with unusual and problematic characteristics that should be evaluated by people and/or programs before those concept are used.
code: P310
Semantic_Type: Conceptual Entity
Display_Name: Concept Status
Preferred_Name: Concept_Status
has exact synonym: Concept_Status

FDA_Table
type: AnnotationProperty
definition: A property used to flag terms that are part of an FDA data standard manual, including Route of Administration, Dosage Form, Package Type and Potency.
code: P317
Semantic_Type: Conceptual Entity
Display_Name: FDA Table
Preferred_Name: FDA_Table
has exact synonym: FDA_Table

FDA_UNII_Code
type: AnnotationProperty
definition: A property representing the FDA Unique Ingredient Identifier, a key component of the federal drug information model.
code: P319
Semantic_Type: Conceptual Entity
Display_Name: FDA UNII Code
Preferred_Name: FDA_UNII_Code
has exact synonym: FDA_UNII_Code

Contributing_Source
type: AnnotationProperty
definition: A property is used to indicate when a non-EVS entity has contributed to, and has a stake in, a concept. This is used where such entities, within or outside NCI, have indicated the need to be able to track their own concepts. A single concept can have multiple instances of this property if multiple entities have such a defined stake.
code: P322
Semantic_Type: Conceptual Entity
Display_Name: Contributing Source
Preferred_Name: Contributing_Source
has exact synonym: Contributing_Source

ALT_DEFINITION
type: AnnotationProperty
definition: A property representing the English language definition of a concept from a source other than NCI.
code: P325
Semantic_Type: Conceptual Entity
Display_Name: [source] Definition
Preferred_Name: ALT_DEFINITION
has exact synonym: ALT_DEFINITION

NCBI_Taxon_ID
type: AnnotationProperty
definition: A property that is used to establish correspondence between the NCI Thesaurus concept representing a taxon (species) and the NCBI/NLM Species Taxonomy ID assigned by the NCBI to that taxon.
code: P331
Semantic_Type: Conceptual Entity
Display_Name: NCBI Taxon ID
Preferred_Name: NCBI_Taxon_ID
has exact synonym: NCBI_Taxon_ID

Chemical_Formula
type: AnnotationProperty
definition: A property representing a concise expression about the atoms that constitute a particular chemical compound.
code: P350
Semantic_Type: Conceptual Entity
Display_Name: Chemical Formula
Preferred_Name: Chemical_Formula
Contributing_Source: CRCH
has exact synonym: Chemical Formula
has exact synonym: Chemical_Formula

Legacy Concept Name
type: AnnotationProperty
read only: true
definition: A property representing a retired unique concept identifier created and stored as Concept Name by legacy EVS software. Use of these values was long discouraged, but continued as late as 2009 when creation of new values ceased and Concept Name was retired. Legacy values are intended solely to help resolve and update earlier coding.
code: P366
Semantic_Type: Conceptual Entity
Preferred_Name: Legacy Concept Name
has exact synonym: Legacy Concept Name
has exact synonym: Legacy_Concept_Name
label: Legacy_Concept_Name

CHEBI_ID
type: AnnotationProperty
definition: A property representing that a concept in the 'Drug, Food, Chemical or Biomedical Material' branch of the NCI thesaurus maps to a specific concept in the EBI Chemical Entities of Biological Interest (CHEBI) database.
code: P368
Semantic_Type: Conceptual Entity
Preferred_Name: CHEBI_ID
has exact synonym: CHEBI_ID

HGNC_ID
type: AnnotationProperty
definition: A property representing that a concept in the 'Gene' branch of the NCI thesaurus maps to a HUGO Gene Nomenclature Committee (HGNC) certified gene.
code: P369
Semantic_Type: Conceptual Entity
Preferred_Name: HGNC_ID
has exact synonym: HGNC_ID
has exact synonym: HUGO_ID

NICHD_Hierarchy_Term
type: AnnotationProperty
definition: A property representing a term chosen by NICHD to be used in the representation of the NICHD hierarchy.
code: P371
Semantic_Type: Conceptual Entity
Preferred_Name: NICHD_Hierarchy_Term
Contributing_Source: NICHD
has exact synonym: NICHD_Hierarchy_Term

Maps_To
type: AnnotationProperty
definition: A property representing that a term in another terminology has been mapped to a term in NCIt and describes the relationship between the mapped terms.
code: P375
Semantic_Type: Conceptual Entity
Preferred_Name: Maps_To
has exact synonym: Maps_To

DesignNote
type: AnnotationProperty
definition: A property representing notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept.
definition: Design notes are notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept.
code: P98
Semantic_Type: Conceptual Entity
Display_Name: DesignNote
Preferred_Name: DesignNote
has exact synonym: DesignNote

has_MedDRA_id
type: AnnotationProperty

ISA alternative term
type: AnnotationProperty
editor preferred label: ISA alternative term
has curation status: IAO_0000122
definition: An alternative term used by the ISA tools project (http://isa-tools.org).
editor note: Requested by Alejandra Gonzalez-Beltran https://sourceforge.net/tracker/?func=detail&aid=3603413&group_id=177891&atid=886178
definition editor: Person: Alejandra Gonzalez-Beltran
definition editor: Person: Philippe Rocca-Serra
definition source: ISA tools project (http://isa-tools.org)
sub property of: alternative term

IEDB alternative term
type: AnnotationProperty
editor preferred label: IEDB alternative term
has curation status: IAO_0000122
definition: An alternative term used by the IEDB.
definition editor: PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters
definition source: IEDB
sub property of: alternative term

symbol from nomenclature authority
type: AnnotationProperty
definition: the symbol assigned by the nomenclature authority
definition editor: Oliver He, Yue Liu

full name from nomenclature authority
type: AnnotationProperty
definition: the full name assigned by the nomenclature authority
definition editor: Oliver He, Yue Liu

NCBI GeneID
type: AnnotationProperty
definition: A GeneID in the NCBI Gene database
definition editor: Oliver He, Yue Liu

NCBI LocusTag
type: AnnotationProperty
definition: the NCBI LocusTag name of a gene
definition editor: Oliver He, Yue Liu

gene map location
type: AnnotationProperty
definition: the map location of a gene
definition editor: Oliver He, Yue Liu

modification date
type: AnnotationProperty
definition: a date of content modification
definition editor: Oliver He, Yue Liu

organism NCBITaxon ID
type: AnnotationProperty
definition: The NCBITaxon ontology ID of an organism.
definition editor: Oliver He, Yue Liu

chromosome ID of gene
type: AnnotationProperty
definition: A chromosome ID where a gene is located.
definition editor: Oliver He

type of gene
type: AnnotationProperty
definition: an annotation property that specifies the type of a gene
definition editor: Oliver He

nomenclature status
type: AnnotationProperty
definition: an annotation property that specifies a nomenclature status
definition editor: Oliver He

has GO association
type: AnnotationProperty
definition: an annotation property that shows the GO information associated with a specific gene.
definition editor: Yongqun He

has PubMed association
type: AnnotationProperty
definition: An annotation property that represents a gene's association with PubMed publication(s).
definition editor: Yongqun He

NCIT code
type: AnnotationProperty
definition: An annotation property that refers to a code defined by NCIT

never in taxon
type: AnnotationProperty
example of usage: tooth SubClassOf 'never in taxon' value 'Aves'
definition: S never_in_taxon T iff: S SubClassOf in_taxon only not T.
definition: x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL.
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/17921072
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20973947
expand assertion to: ?X DisjointWith RO_0002162 some ?Y
expand assertion to: Class: <http://www.w3.org/2002/07/owl#Nothing> EquivalentTo: ?X and (RO_0002162 some ?Y)
database cross reference: RO:0002161
has_obo_namespace: uberon
id: never_in_taxon
is class level: true
is metadata tag: true
shorthand: never_in_taxon
label: never_in_taxon

dubious_for_taxon
type: AnnotationProperty
definition: S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T.
database cross reference: RO:0002174
has_obo_namespace: uberon
id: dubious_for_taxon
is class level: true
is metadata tag: true
shorthand: dubious_for_taxon
comment: this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost

present in taxon
type: AnnotationProperty
definition: S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S
definition: S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S.
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
database cross reference: RO:0002175
has exact synonym: applicable for taxon
has_obo_namespace: uberon
id: present_in_taxon
is class level: true
is metadata tag: true
shorthand: present_in_taxon
label: present_in_taxon

logical macro assertion
type: AnnotationProperty

logical macro assertion on a property
type: AnnotationProperty
sub property of: logical macro assertion

logical macro assertion on an object property
type: AnnotationProperty
sub property of: logical macro assertion on a property

is directional form of
type: AnnotationProperty
created by: cjm
creation date: 2018-03-13T23:59:29Z
sub property of: logical macro assertion on an object property

is positive form of
type: AnnotationProperty
created by: cjm
creation date: 2018-03-14T00:03:16Z
sub property of: is directional form of

curator note
type: AnnotationProperty
definition: An administrative note of use for a curator but of no use for a user.
definition source: curator note
description adapted from source: no
property has curation status: organizational term
database cross reference: IAO:0000232
has exact synonym: editor_notes

definition source
type: AnnotationProperty
definition: A source from where the formal description was derived. This can be in the form of a link to a relevant webpage, the IRI of a term in an existing ontology, a reference to specific literature, etc.
definition source: definition source
description adapted from source: yes
property has curation status: metadata complete - requires restrictions and relationships
database cross reference: IAO:0000119
preferred label: description source

description adapted from source
type: AnnotationProperty
definition: An assertion of whether or not the term/class description is an adaptation of the description in the description source.
curator note: Requested inclusion of this property into RO. Check details here again after inclusion.
property has curation status: metadata complete - requires restrictions and relationships
creator: SCDO

property has curation status
type: AnnotationProperty
definition: Description inherent in name (not provided by source)
description adapted from source: Only label adapted
property has curation status: organizational term

existence in other ontologies
type: AnnotationProperty
definition: An indication of whether a term/class already exists in other ontologies. Only used for term (descriptions) that were not taken directly from an existing ontology.
creator: SCDO (Jade Hotchkiss)

previous identifier
type: AnnotationProperty
definition: Used to record the identifier that had been used previously but is no longer in use.
creator: SCDO (Jade Hotchkiss)

STATO alternative term
type: AnnotationProperty
definition: an alternative term used for STATO statistical ontology and ISA team
definition editor: Alejandra Gonzalez-Beltran
definition editor: Orlaith Burke
definition editor: Philippe Rocca-Serra
sub property of: alternative term

external_definition
type: AnnotationProperty
definition: An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
database cross reference: UBPROP:0000001
has_obo_namespace: uberon
id: external_definition
is metadata tag: true
shorthand: external_definition
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

axiom_lost_from_external_ontology
type: AnnotationProperty
definition: A textual description of an axiom loss in this ontology compared to an external ontology.
database cross reference: UBPROP:0000002
has_obo_namespace: uberon
id: axiom_lost_from_external_ontology
is metadata tag: true
shorthand: axiom_lost_from_external_ontology
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

homology_notes
type: AnnotationProperty
definition: Notes on the homology status of this class.
database cross reference: UBPROP:0000003
has_obo_namespace: uberon
id: homology_notes
is metadata tag: true
shorthand: homology_notes
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

provenance_notes
type: AnnotationProperty
database cross reference: UBPROP:0000004
has_obo_namespace: uberon
id: provenance_notes
is metadata tag: true
shorthand: provenance_notes

has_relational_adjective
type: AnnotationProperty
curator note: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
database cross reference: UBPROP:0000007
has_obo_namespace: uberon
id: has_relational_adjective
is metadata tag: true
shorthand: has_relational_adjective

taxon_notes
type: AnnotationProperty
definition: Notes on the how instances of this class vary across species.
database cross reference: UBPROP:0000008
has_obo_namespace: uberon
id: taxon_notes
is metadata tag: true
shorthand: taxon_notes

structure_notes
type: AnnotationProperty
definition: Notes on the structure, composition or histology of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database cross reference: UBPROP:0000010
has_obo_namespace: uberon
id: structure_notes
is metadata tag: true
shorthand: structure_notes

development_notes
type: AnnotationProperty
definition: Notes on the ontogenic development of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database cross reference: UBPROP:0000011
has_obo_namespace: uberon
id: development_notes
is metadata tag: true
shorthand: development_notes

external_ontology_notes
type: AnnotationProperty
definition: Notes on how similar or equivalent classes are represented in other ontologies.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database cross reference: UBPROP:0000012
has_obo_namespace: uberon
id: external_ontology_notes
is metadata tag: true
shorthand: external_ontology_notes

fma_set_term
type: AnnotationProperty
external_ontology_notes: FMA has terms like 'set of X'. In general we do not include set-of terms in uberon, but provide a mapping between the singular form and the FMA set term
database cross reference: UBPROP:0000202
has_obo_namespace: uberon
id: fma_set_term
is metadata tag: true
shorthand: fma_set_term

in subset of ONS
type: AnnotationProperty
definition: Super-property collecting all annotation properties assigning classes in ONS to specific subset (i.e. Metadata search). For each subset, there will be an annotation property. To assign a class to a subset, set the annotation property value to "TRUE"
sub property of: in subset

in minimal requirement ONS subset
type: AnnotationProperty
definition: Annotation properties assigning a class to the ONS-subset of metadata search classes. Set value to "TRUE" to assign a class.
sub property of: in subset of ONS

from Alzheimer Ontology
type: AnnotationProperty
definition: this indicates that the term originates from the Alzheimer Ontology by Fraunhofer SCAI

excluded from QC check
type: AnnotationProperty
id: excluded_from_qc_check
is metadata tag: true

excluded subClassOf
type: AnnotationProperty
id: excluded_subClassOf
is metadata tag: true

has_rank
type: AnnotationProperty
definition: A metadata relation between a class and its taxonomic rank (eg species, family)
has_obo_namespace: ncbi_taxonomy

contributor
type: AnnotationProperty
has_obo_namespace: uberon
id: dc-contributor
is metadata tag: true
shorthand: dc-contributor

dc:creator
type: AnnotationProperty
definition: An entity primarily responsible for making the resource. (This property is used in the SCDO when a term was created by the SCDO Working Group or a curator.) The SCDO uses this especially to apply to term descriptions.
definition source: creator
description adapted from source: no
property has curation status: ready for release
description: Examples of a Creator include a person, an organisation, or a service. Typically, the name of a Creator should be used to indicate the entity.
comment: An entity primarily responsible for making the content of the resource.
label: Creator

Date
type: AnnotationProperty
description: Typically, Date will be associated with the creation or availability of the resource. Recommended best practice for encoding the date value is defined in a profile of ISO 8601 [W3CDTF] and follows the YYYY-MM-DD format.
comment: A date associated with an event in the life cycle of the resource.

Description
type: AnnotationProperty
description: Description may include but is not limited to: an abstract, table of contents, reference to a graphical representation of content or a free-text account of the content.
has_obo_namespace: uberon
id: dc-description
is metadata tag: true
shorthand: dc-description
comment: An account of the content of the resource.
label: description

identifier
type: AnnotationProperty
python name: identifier_dc

relation
type: AnnotationProperty

contributor
type: AnnotationProperty
has_obo_namespace: uberon
id: dc-contributor
is metadata tag: true
shorthand: dc-contributor

is referenced by
type: AnnotationProperty
sub property of: relation

relation
type: AnnotationProperty
sub property of: relation

has_alternative_id
type: AnnotationProperty
definition: ID of merged class.

has_broad_synonym
type: AnnotationProperty
label: has broad synonym
sub property of: has synonym

database cross reference
type: AnnotationProperty
definition: A database cross-reference. An annotation which directs one to information contained within a database.
definition: A property representing a reference to an identical or very similar object in another database.
definition: Reference database or publication source.
Semantic_Type: Conceptual Entity
Preferred_Name: xRef
definition source: SBO:0000554
property has curation status: metadata complete - requires restrictions and relationships
database cross reference: IAO:0100001
database cross reference: SBO:0000554
has exact synonym: DbXref
has exact synonym: Xref
has exact synonym: database cross-reference
has exact synonym: database_cross_reference
has exact synonym: db xref
has exact synonym: hasDbXref
label: database_cross_reference
label: has database cross reference
label: xRef
label: 数据库_交叉_引用

has exact synonym
type: AnnotationProperty
definition: A property representing a fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software.
definition: An alias in which the alias exhibits true synonymy. Example: ornithine cycle is an exact synonym of urea cycle.
definition: Exact synonym.
definition: Fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software.
description adapted from source: no
property has curation status: pending vetting by the SCDO developers
database cross reference: IAO:0100001
has exact synonym: FULL_SYN
has exact synonym: Synonym with Source Data
label: hasExactSynonym
label: has_exact_synonym
sub property of: has synonym

has_narrow_synonym
type: AnnotationProperty
label: has narrow synonym

has_obo_namespace
type: AnnotationProperty
definition: Name space of the ontology.
database cross reference: IAO:0100001
comment: disease_ontology
label: 有_obo_命名空间

has_related_synonym
type: AnnotationProperty
definition: Has related synonym.
label: has related synonym

has synonym
type: AnnotationProperty

id
type: AnnotationProperty
definition: An identifier is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity.

in subset
type: AnnotationProperty
definition: An association that connects the concept defining a particular terminology subset with concepts that belong to this subset.
definition: In subset.
definition: Used to associate the concept defining a particular terminology subset with concepts that belong to this subset.
has exact synonym: Concept_In_Subset
label: in_subset

shorthand
type: AnnotationProperty
editor preferred label: shorthand
database cross reference: IAO:0100001

comment
type: AnnotationProperty
definition: Comment.

rdfs:isDefinedBy
type: AnnotationProperty
definition: Is defined by.
OBO foundry unique label: is defined by

label
type: AnnotationProperty
editor preferred label: label
definition: A human readable name for this class.
definition: A human-readable name for the class/term.
description adapted from source: yes
comment: A human-readable name for the subject.
label: rdfs:label
label: 标签

see also
type: AnnotationProperty
database cross reference: seeAlso
has_obo_namespace: uberon
id: seeAlso
is class level: true
is metadata tag: true
shorthand: seeAlso
python name: see_also_rdf_schema
label: seeAlso

equivalent property
type: AnnotationProperty

has exact match
type: AnnotationProperty
definition: A skos concept mapping used to link two concepts, indicating a high degree of confidence that the concepts can be used interchangeably.

skos:prefLabel
type: AnnotationProperty
definition: A preferred label.
description adapted from source: yes
property has curation status: pending vetting by the SCDO developers

depicted by
type: AnnotationProperty
has_obo_namespace: uberon
id: depicted_by
is metadata tag: true
shorthand: depicted_by

alternate name
type: AnnotationProperty

Library of Congress Subject Headings
type: AnnotationProperty
python name: library_of_congress_subject_headings
equivalent property: http://purl.org/dc/terms/LCSH
VIAF ID: https://viaf.org/viaf/174475040

Library of Congress Classification
type: AnnotationProperty
python name: library_of_congress_classification

see also
type: AnnotationProperty
python name: see_also_wikidata

ICD-9-CM
type: AnnotationProperty
python name: icd9cm

NCI Thesaurus ID
type: AnnotationProperty
python name: nci_thesaurus_id

different from
type: AnnotationProperty
python name: different_from

VIAF ID
type: AnnotationProperty
python name: viaf_id

Medical Dictionary for Regulatory Activities ID
type: AnnotationProperty
python name: medical_dictionary_for_regulatory_activities_id

MeSH Descriptor ID
type: AnnotationProperty
python name: mesh_descriptor_id
comment: Such as C004931 for DPPH or D008180 for systemic lupus erythematosus.

SNOMED CT Identifier
type: AnnotationProperty
python name: snomed_ct_identifier

isTreatmentFor
type: ObjectProperty
definition: The subject describes a clinically approved drug or therapy for a condition (object).

isSignAndSymptomFor
type: ObjectProperty
definition: The subject describes as sign/symptom or multiple signs/symptoms for the object.

isRiskFactorFor
type: ObjectProperty
definition: The subject possesses characteristics leading to an increased risk in developing a certain phenotype or condition (object). The example of risk factors could be age, family history, consumption of certain products, being exposed to chemicals or radiations, having certain underlying conditions or being infected by an microorganism

isModelFor
type: ObjectProperty
definition: The subject serves as an in vivo model for the study of a certain phenotype (object) during pre-clinical phase.

isDiagnosisFor
type: ObjectProperty
definition: The subject is a technique carried out in a clinical assessment for evaluation of a condition (object).

isClinicalMarkerFor
type: ObjectProperty
definition: An subject that is a symptom, a sign, an underlying disease, a molecular abnormality, or a clinical result/outcome characterised as the key marker for the diagnosis/onset/classification of a certain condition (object).

isCellularProcessFor
type: ObjectProperty
definition: The subject describes any process that is carried out at the cellular level, but not necessarily restricted to a single cell for the object.

isAnatomicalEntityFor
type: ObjectProperty
sub property of: topObjectProperty
definition: A relation describing an anatomical feature of the referenced object with a material entity.

VariantisGeneticRiskFactorFor
type: ObjectProperty
definition: The subject gene has variation that can lead to an increased disease risk, but does not directly cause a disease.

positively regulates
type: ObjectProperty
type: TransitiveProperty
imported from: ro.owl
OBO foundry unique label: positively regulates (process to process)
is positive form of: RO_0002211
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam

molecularly interacts with
type: ObjectProperty
type: SymmetricProperty
imported from: ro.owl

cognitive symptom
type: Class
subclass of: nervous system symptom
definition: Cognitive symptoms involve problems with concentration and memory and can be just as disabling as the other types of symptoms. The onset of cognitive symptoms is usually realised in the same way as negative symptoms in that they only begin to be noticeable after the dominance of psychotic episodes or positive symptoms have either been controlled with medication or diminished with age.
comment on definition: Modified Defintion

TM_BIN_VariantisGeneticRiskFactorFor
type: Class
equivalent class: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease

TM_BIN_isSignAndSymptomFor
type: Class
equivalent class: Restriction
  on property: isSignAndSymptomFor
  some values from: Alzheimer's disease

TM_BIN_isTreatmentFor
type: Class
equivalent class: Restriction
  on property: isTreatmentFor
  some values from: Alzheimer's disease

early sign
type: Class
subclass of: sign
definition: A sign that arises in the early/preclinical stage of a disease
has synonym: early clue
has synonym: early hint

Early-stage Alzheimer's Disease (mild)
type: Class
subclass of: disease stage
definition: A disease stage at which a person may function independently. He or she may still drive, work and be a part of social activities. Despite this, the person may feel as if he or she is having memory lapses, such as forgetting familiar words or the location of everyday objects.
has db xref: https://www.alz.org/alzheimers-dementia/stages

Middle-stage Alzheimer's Disease (moderate)
type: Class
subclass of: disease stage
definition: A disease in the middle stage where the dementia symptoms are more pronounced. The person may confuse words, get frustrated or angry, and act in unexpected ways, such as refusing to bathe. Damage to nerve cells in the brain can also make it difficult for the person to express thoughts and perform routine tasks without assistance.
has db xref: https://www.alz.org/alzheimers-dementia/stages

Personality and behavioral changes
type: Class
subclass of: cognitive symptom
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: dementia due to Alzheimer's disease
has db xref: A behavioral symptom of Alzheimer's disease that encompasses getting upset, worried, and angry more easily. Acting depressed or not interested in things or hiding things or believing that other people are hiding things. It also causes to imagining things that aren't there etc.
has db xref: https://www.nia.nih.gov/health/managing-personality-and-behavior-changes-alzheimers#:~:text=Common%20Changes%20in%20Personality%20and%20Behavior&text=Getting%20upset%2C%20worried%2C%20and%20angry,things%20that%20aren't%20there

Late-stage Alzheimer's Disease(severe)
type: Class
subclass of: disease stage
definition: A disease at late stage where dementia symptoms are severe. Individuals lose the ability to respond to their environment, to carry on a conversation and, eventually, to control movement. They may still say words or phrases, but communicating pain becomes difficult. As memory and cognitive skills continue to worsen, significant personality changes may take place and individuals need extensive care.
has db xref: https://www.alz.org/alzheimers-dementia/stages
has synonym: Dementia-stage Alzheimer's Disease

preclinical stage of Alzheimer's disease
type: Class
subclass of: Alzheimer's disease
definition: A disease stage of Alzheimer's disease that begins long before any symptoms become apparent. The symptoms go unnoticed by the patients and people around them and this stage can last for years, possibly even decades.
has db xref: https://pubmed.ncbi.nlm.nih.gov/21514248/
has exact synonym: preclinical Alzheimer

mild cognitive impairment due to Alzheimer's disease
type: Class
subclass of: Alzheimer's disease
definition: A stage of Alzheimer's disease where symptoms appear such as concern regarding a change in cognition (raised either by the patient himself/herself or by an informant who knows the patient well), impairment in one or more cognitive domains, preservation of independence in functional abilities and other non-demented symptoms.
has db xref: https://pubmed.ncbi.nlm.nih.gov/21514249/
has synonym: predementia phase of Alzheimer's disease

dementia due to Alzheimer's disease
type: Class
subclass of: Alzheimer's disease
definition: A disease of which the patient at this stage suffer from memory loss, impaired ability to think, or making decisions that interferes with doing everyday activities.
has db xref: https://pubmed.ncbi.nlm.nih.gov/27307128/

concern regarding a change in cognition
type: Class
subclass of: emotional behavior
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: mild cognitive impairment due to Alzheimer's disease
definition: An emotion milder than worry raised by either the patient, or the informant who knows the patient well, or from a skilled clinician observing, about cognitive changes in the patient.
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/21514249/
comment on definition: Modified definition

preservation of independence in functional abilities
type: Class
subclass of: behavioral symptom
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: mild cognitive impairment due to Alzheimer's disease
definition: A symptom that entails mild problems performing complex functional tasks which they used to perform previously, such as paying bills, preparing a meal, or shopping. The person requires more time, is less efficient, and makes more errors at performing such activities than in the past. Nevertheless, the person generally maintains their independence of function in daily life.
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/21514249/

episodic memory impairment
type: Class
subclass of: cognitive symptom
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: mild cognitive impairment due to Alzheimer's disease
definition: A mental impairment in the ability to learn and retain new information, or recall information about a specific event that has occurred at a specific time and place.
alternative term: memory impairment
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/21514249/
comment on definition: Modified definition
has exact synonym: impairment in episodic memory

Free and Cued Selective Reminding Test
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A memory test that controls attention and acquisition, by providing category cues in the learning process.
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/25062746/
has exact synonym: FCSRT Test

Boston Naming Test
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A measure of confrontation naming that takes into account the finding that patients with dysnomia often have greater difficulties with the naming of low frequency objects and consists of 60 black and white line drawings of objects
has db xref: https://link.springer.com/referenceworkentry/10.1007/978-0-387-79948-3_869#:~:text=The%20Boston%20Naming%20Test%20(BNT,naming%20of%20low%20frequency%20objects.
has exact synonym: BNT Test

category and letter verbal fluency test
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A short screening test that evaluates language skills and it consists of Semantic verbal Fluency Tests (SFT) and Categorical verbal Fluency Tests (CFT).
has db xref: https://www.frontiersin.org/articles/10.3389/fpsyg.2019.02797/full
has synonym: verbal fluency test

informal cognitive testing
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A testing tool that uses a variety of simple and informal techniques, performed by clinicians. For example, the clinician can ask a patient to learn a street address and to recall it after a delay interval of a few minutes.
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/21514249/

longitudinal cognitive evaluation
type: Class
subclass of: Longitudinal Study
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A clinical tool that measures and evaluates cognition of the patient with certain time intervals while maintaining the consistency in parameters employed in testing.
has db xref: https://www.sciencedirect.com/science/article/pii/S2352872918300824

probable Alzheimer dementia
type: Class
subclass of: dementia due to Alzheimer's disease
definition: A type of dementia which which the person meets the core clinical creteria for probable Alzheimer dementia.

impaired reasoning
type: Class
subclass of: cognitive symptom
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: dementia due to Alzheimer's disease
definition: A symptom with which a patient may misunderstand the motives of the actions of their family, friends or others
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/21514250/

impaired language functions
type: Class
subclass of: cognitive symptom
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: dementia due to Alzheimer's disease
definition: A symptom including defficulty thinking of common words while speaking, hesitations, speech, spelling, and writing errors.
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/21514250/

insidious onset of dementia
type: Class
subclass of: disease stage
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: probable Alzheimer dementia
definition: A stage where symptoms have a gradual onset over months to years but with harmful effects, not sudden within hours or days.
has db xref: https://pubmed.ncbi.nlm.nih.gov/9546336/

amnestic symptom
type: Class
subclass of: cognitive symptom
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: probable Alzheimer dementia
definition: A symptom including impairment in learning and recalling of recently learned information, loss of memory, disorientation with time and space, lack of insight to their memory loss and being aware of their memory loss but not being able to understand why.
has db xref: https://hospitals.aku.edu/pakistan/diseases-and-conditions/Pages/amnestic-disorder.aspx

non-demented cognitive impairment
type: Class
subclass of: cognitive symptom
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: mild cognitive impairment due to Alzheimer's disease
definition: A symptom that is sufficiently mild that there is no evidence of a significant impairment in social or occupational functioning.
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/21514249/

possible Alzheimer dementia
type: Class
subclass of: dementia due to Alzheimer's disease
definition: A type of Alzheimer dementia whic meets core clinical criteria for possible Alzheimer dementia
has db xref: https://www.nia.nih.gov/health/alzheimers-disease-diagnostic-guidelines

sudden onset of cognitive impairment
type: Class
subclass of: disease stage
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: possible Alzheimer dementia
definition: A stage where cognitive impiarment suddenly arises
has db xref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331682/

asymptomatic cerebral amyloidosis
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: preclinical stage of Alzheimer's disease
definition: A biological process by which an individual has biomarker evidence of amyloid-beta accumulation with elevated tracer retention on PET amyloid imaging and/or low amyloid-beta 42 in CSF assay, but no detectable evidence of additional brain alterations suggestive of neurodegeneration or subtle cognitive and/or behavioral symptomatology.
has PubMed association: true
has db xref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220946/

amyloid positivity
type: Class
subclass of: clinical measurement
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A result from clinical assessment that characterizes presence of abnormal amyloid found with cerebrospinal fluid (CSF) and/or positron emission tomography (PET)
has db xref: https://pubmed.ncbi.nlm.nih.gov/25713403/

amyloid-beta 42/amyloid-beta 40 ratio
type: Class
subclass of: ratio
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A ratio between amyloid-beta 42 and amyloid-beta 40. Decreased ratio of amyloid-beta 42/40 is a strong marker of Alzheimer's disease.
has db xref: https://www.svarlifescience.com/services/wieslab-diagnostic-services/997-l-beta-amyloid-ratio-42-40#:~:text=Beta%20amyloid%2040%20is%20the,even%20before%20clinical%20dementia%20occurs.

APOE genotype test
type: Class
subclass of: blood measurement
definition: A technique used to determine the specific apolipoprotein E (APOE) genotypes in patients with type III hyperlipoproteinemia
has exact synonym: APOE genotyping
has exact synonym: Apolipoprotein E Genotyping
see also: https://www.mayocliniclabs.com/test-catalog/Overview/35358

BACE1 inhibitor
type: Class
subclass of: enzyme inhibitor
definition: An inhibitor that interferes the chemical reaction of BACE1
has exact synonym: beta-site APP cleaving enzyme 1 inhibitor

beta-secretase 1 measurement
type: Class
subclass of: clinical measurement
definition: A measurement that quantifies the amount of beta-secretase 1 (BACE1) normally found in blood or cerebrospinal fluid. The quantification of the amount of beta-secretase 1 in a sample, typicallly cerebrospinal fluid. Beta-secretase-1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells, and is thought to have a role in Alzheimer's disease pathogenesis.
definition: Quantification of the amount of beta-secretase 1 in a sample, typicallly cerebrospinal fluid. Beta-secretase-1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells, and is thought to have a role in Alzheimer's disease pathogenesis.
see also: https://pubmed.ncbi.nlm.nih.gov/31745860/

Brief Alzheimer Screen test
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A test developed from cognitive assessments on 406 normal subjects and 342 mild AD patients in the CERAD (Consortium to Establish a Registry for AD) dataset.
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/14646030/
has exact synonym: BAS (Brief Alzheimer Screen) Screening Test

Cambridge Neuropsychological Test Automated Battery for Alzheimer disease
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A tool to assess cognitive functions in diverse neurological and psychiatric disorders, such as dementia, schizophrenia, depression, Parkinson's Disease.
has db xref: https://pubmed.ncbi.nlm.nih.gov/16085791/
has exact synonym: CANTAB-Alz

caffeine consumption
type: Class
subclass of: Lifestyle
definition: A behavior of consuming caffeine-containing products such as coffee, tea, cacao, energy drinks
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/8603790/

DemTect screening test
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A tool used as a new 6-8 minute dementia screening, consisting of 5 short subtests, which is objective both in performance and evaluation.
has db xref: https://www.researchgate.net/publication/285702266_DemTect_A_new_screening_method_to_support_diagnosis_of_dementia

tobacco consumption
type: Class
subclass of: Lifestyle
definition: A behavior of consuming tabacco products
has db xref: https://www.alzheimers.org.uk/about-dementia/risk-factors-and-prevention/smoking-and-dementia#:~:text=It%20is%20known%20that%20smoking,the%20development%20of%20Alzheimer's%20disease.

Everyday Cognition questionnaire
type: Class
equivalent class: Class
  intersection of: Clinical or Research Assessment Questionnaire
  intersection of: Restriction
    on property: isDiagnosisFor
    some values from: Alzheimer's disease
definition: A questionnaire comprised of multiple subscales evaluating everyday cognitive function
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/18590364/
has exact synonym: Ecog questionnaire

Global Deterioration Scale
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A method used for assessment of primary degenerative dementia and delineation of its stages
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/7114305/
has exact synonym: GDS scale

traumatic brain injury
type: Class
subclass of: disease of anatomical entity
subclass of: Restriction
  on property: isRiskFactorFor
  some values from: Alzheimer's disease
definition: Traumatic brain injury usually results from a violent blow or jolt to the head or body. An object that goes through brain tissue, such as a bullet or shattered piece of skull, also can cause traumatic brain injury.
has db xref: https://www.mayoclinic.org/diseases-conditions/traumatic-brain-injury/symptoms-causes/syc-20378557

Inability to communicate
type: Class
subclass of: cognitive symptom
definition: A symptom of failure to communicate with others.
has db xref: https://pubmed.ncbi.nlm.nih.gov/23522497/

Inability to recognize oneself or family
type: Class
subclass of: cognitive symptom
definition: A cognitive symptom of failure to recognize oneself's or family member's identity
has db xref: https://pubmed.ncbi.nlm.nih.gov/22553492/

Memory Orientation Screening Test
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A test that separates normal from MCI and demented elders in a prevalence-stratified sample
has db xref: https://www.omicsonline.org/the-memory-orientation-screening-test-most-accurately-separates-normal-from-mci-and-demented-elders-in-a-prevalence-stratified-sample-2161-0460.1000109.php
has exact synonym: MOST test

Neurobehavioral Cognitive Status Examination
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A screening examination that assesses cognition in a brief but quantitative fashion, uses independent tests to evaluate functioning within five major cognitive ability areas: language, constructions, memory, calculations, and reasoning.
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/3631786/
has exact synonym: NCSE

Short Portable Mental Status Questionnaire (SPMSQ)
type: Class
subclass of: Clinical or Research Assessment Questionnaire
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A questionaire with 10 items that can be easily administered by clinicians in mental impairment diagnosis
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/1159263/
has exact synonym: SPMSQ

Xiusanzhen
type: Class
subclass of: medical intervention
definition: An acupuncture method that involves pucture at bilateral Yingxiang and Yintang points
has PubMed association: true
has db xref: https://pubmed.ncbi.nlm.nih.gov/21717774/

total tau
type: Class
subclass of: protein
definition: A protein that is regarded as a general marker of neurodegeneration for evaluation in future population-based studies and represents the total tau concentration in a given sample.
has db xref: https://pubmed.ncbi.nlm.nih.gov/15178952/

phosphorylated tau
type: Class
subclass of: protein
definition: A protein that is phosphorylated through post-translational modification. Its accumulation reflects the formation of neurofibrillary tangles, synaptic impairment, and neuronal dysfunction.
has db xref: https://pubmed.ncbi.nlm.nih.gov/32812023/

insulin signalling
type: Class
subclass of: signaling
definition: a signaling process that is initiated through binding and activation of its cell-surface receptor and initiates a cascade of phosphorylation and dephosphorylation events, second-messenger generation, and protein-protein interactions that result in diverse metabolic events in almost every tissue
has db xref: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/insulin-signaling

neurotrophic signalling
type: Class
subclass of: signaling
definition: A signaling process through which neurotrophins modulate long-term potentiation, dendritic complexity and axon branching, processes that promote synaptic efficacy and thus learning and memory.
has PubMed association: true
has db xref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295469/

phospatidylinositol signalling
type: Class
subclass of: signaling
definition: An internal signaling process in response to extracellular signals through which phosphatidylinositols undergo rapid turnover and generate second messengers including diacylglycerol, inositol 1,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate (PtdIns 3,4P2) and phosphatidylinositol 3,4,5-trisphosphate.
has db xref: https://pubmed.ncbi.nlm.nih.gov/9599410

entity
type: Class
BFO OWL specification label: entity
BFO CLIF specification label: Entity
editor preferred label: entity
example of usage: Julius Caesar
example of usage: Verdi’s Requiem
example of usage: the Second World War
example of usage: your body mass index
editor note: BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81
editor note: Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
imported from: agro.owl
imported from: ecocore.owl
imported from: envo.owl
imported from: ero.owl
imported from: mondo.owl
imported from: obi.owl
imported from: ogg.owl
imported from: ons.owl
imported from: uberon.owl
elucidation: An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])

Axiom
annotated source: entity
annotated property: editor note
annotated target: Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000004
comment: per discussion with Barry Smith

Axiom
annotated source: entity
annotated property: elucidation
annotated target: An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/001-001

continuant
type: Class
subclass of: entity
disjoint with: occurrent
BFO OWL specification label: continuant
BFO CLIF specification label: Continuant
editor preferred label: continuant
definition: An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.
editor note: BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240
editor note: Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
imported from: envo.owl
imported from: mondo.owl
imported from: obi.owl
imported from: ogg.owl
imported from: ons.owl
imported from: pato.owl
imported from: po.owl
imported from: ro.owl
imported from: uberon.owl
elucidation: A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
has associated axiom(nl): if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
has associated axiom(nl): if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
has associated axiom(nl): if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
has associated axiom(fol): (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
has associated axiom(fol): (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]

Axiom
annotated source: continuant
annotated property: editor note
annotated target: Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000007

Axiom
annotated source: continuant
annotated property: elucidation
annotated target: A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/008-002

Axiom
annotated source: continuant
annotated property: has associated axiom(nl)
annotated target: if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/126-001

Axiom
annotated source: continuant
annotated property: has associated axiom(nl)
annotated target: if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/009-002

Axiom
annotated source: continuant
annotated property: has associated axiom(nl)
annotated target: if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/011-002

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/009-002

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/126-001

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/008-002

Axiom
annotated source: continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/011-002

occurrent
type: Class
subclass of: entity
BFO OWL specification label: occurrent
BFO CLIF specification label: Occurrent
editor note: BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region
editor note: BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players.
editor note: Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
editor note: Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
imported from: ero.owl
elucidation: An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
has associated axiom(nl): Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
has associated axiom(nl): b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
has associated axiom(fol): (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
has associated axiom(fol): (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]

Axiom
annotated source: occurrent
annotated property: editor note
annotated target: Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000006
comment: per discussion with Barry Smith

Axiom
annotated source: occurrent
annotated property: editor note
annotated target: Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000012

Axiom
annotated source: occurrent
annotated property: elucidation
annotated target: An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/077-002

Axiom
annotated source: occurrent
annotated property: has associated axiom(nl)
annotated target: Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/108-001

Axiom
annotated source: occurrent
annotated property: has associated axiom(nl)
annotated target: b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/079-001

Axiom
annotated source: occurrent
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/108-001

Axiom
annotated source: occurrent
annotated property: has associated axiom(fol)
annotated target: (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/079-001

independent continuant
type: Class
subclass of: continuant
disjoint with: specifically dependent continuant
disjoint with: generically dependent continuant
BFO OWL specification label: ic
BFO CLIF specification label: IndependentContinuant
example of usage: a chair
example of usage: a heart
example of usage: a leg
example of usage: a molecule
example of usage: a spatial region
example of usage: an atom
example of usage: an orchestra.
example of usage: an organism
example of usage: the bottom right portion of a human torso
example of usage: the interior of your mouth
definition: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
imported from: ogg.owl
imported from: uberon.owl
has associated axiom(nl): For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
has associated axiom(nl): For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
has associated axiom(fol): (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
has associated axiom(fol): (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
has associated axiom(fol): (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]

Axiom
annotated source: independent continuant
annotated property: definition
annotated target: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/017-002

Axiom
annotated source: independent continuant
annotated property: has associated axiom(nl)
annotated target: For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/134-001

Axiom
annotated source: independent continuant
annotated property: has associated axiom(nl)
annotated target: For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/018-002

Axiom
annotated source: independent continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/134-001

Axiom
annotated source: independent continuant
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/018-002

Axiom
annotated source: independent continuant
annotated property: has associated axiom(fol)
annotated target: (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/017-002

spatial region
type: Class
subclass of: immaterial entity
disjoint with: site
disjoint with: continuant fiat boundary
BFO OWL specification label: s-region
BFO CLIF specification label: SpatialRegion
editor note: BFO 2 Reference: Spatial regions do not participate in processes.
editor note: Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional.
elucidation: A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])
has associated axiom(nl): All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])
has associated axiom(fol): (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001]
has associated axiom(fol): (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001]

Axiom
annotated source: spatial region
annotated property: editor note
annotated target: Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000002
comment: per discussion with Barry Smith

Axiom
annotated source: spatial region
annotated property: elucidation
annotated target: A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/035-001

Axiom
annotated source: spatial region
annotated property: has associated axiom(nl)
annotated target: All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/036-001

Axiom
annotated source: spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/036-001

Axiom
annotated source: spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/035-001

temporal region
type: Class
subclass of: occurrent
disjoint with: spatiotemporal region
disjoint with: process
disjoint with: process boundary
BFO OWL specification label: t-region
BFO CLIF specification label: TemporalRegion
editor note: Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
elucidation: A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
has associated axiom(nl): All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
has associated axiom(nl): Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
has associated axiom(fol): (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
has associated axiom(fol): (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
has associated axiom(fol): (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]

Axiom
annotated source: temporal region
annotated property: editor note
annotated target: Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000003
comment: per discussion with Barry Smith

Axiom
annotated source: temporal region
annotated property: elucidation
annotated target: A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/100-001

Axiom
annotated source: temporal region
annotated property: has associated axiom(nl)
annotated target: All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/101-001

Axiom
annotated source: temporal region
annotated property: has associated axiom(nl)
annotated target: Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/119-002

Axiom
annotated source: temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/119-002

Axiom
annotated source: temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/101-001

Axiom
annotated source: temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/100-001

two-dimensional spatial region
type: Class
subclass of: spatial region
disjoint with: three-dimensional spatial region
BFO OWL specification label: 2d-s-region
BFO CLIF specification label: TwoDimensionalSpatialRegion
example of usage: an infinitely thin plane in space.
example of usage: the surface of a sphere-shaped part of space
elucidation: A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])
has associated axiom(fol): (forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001]

Axiom
annotated source: two-dimensional spatial region
annotated property: elucidation
annotated target: A two-dimensional spatial region is a spatial region that is of two dimensions. (axiom label in BFO2 Reference: [039-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/039-001

Axiom
annotated source: two-dimensional spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (TwoDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [039-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/039-001

spatiotemporal region
type: Class
subclass of: occurrent
BFO OWL specification label: st-region
BFO CLIF specification label: SpatiotemporalRegion
example of usage: the spatiotemporal region occupied by a human life
example of usage: the spatiotemporal region occupied by a process of cellular meiosis.
example of usage: the spatiotemporal region occupied by the development of a cancer tumor
elucidation: A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001])
has associated axiom(nl): All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001])
has associated axiom(nl): Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001])
has associated axiom(nl): Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001])
has associated axiom(nl): Every spatiotemporal region occupies_spatiotemporal_region itself.
has associated axiom(nl): Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002])
has associated axiom(fol): (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002]
has associated axiom(fol): (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001]
has associated axiom(fol): (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001]
has associated axiom(fol): (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001]
has associated axiom(fol): (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001]

Axiom
annotated source: spatiotemporal region
annotated property: elucidation
annotated target: A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/095-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(nl)
annotated target: All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/096-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(nl)
annotated target: Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/099-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(nl)
annotated target: Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/098-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(nl)
annotated target: Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/107-002

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(fol)
annotated target: (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/107-002

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/099-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/096-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/095-001

Axiom
annotated source: spatiotemporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/098-001

process
type: Class
subclass of: occurrent
BFO OWL specification label: process
BFO CLIF specification label: Process
example of usage: a process of cell-division, \ a beating of the heart
example of usage: a process of meiosis
example of usage: a process of sleeping
example of usage: the course of a disease
example of usage: the flight of a bird
example of usage: the life of an organism
example of usage: your process of aging.
definition: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
editor note: BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)
imported from: ero.owl
imported from: ogms.owl
has associated axiom(fol): (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]

Axiom
annotated source: process
annotated property: definition
annotated target: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/083-003

Axiom
annotated source: process
annotated property: has associated axiom(fol)
annotated target: (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/083-003

disposition
type: Class
subclass of: realizable entity
disjoint with: role
BFO OWL specification label: disposition
BFO CLIF specification label: Disposition
example of usage: an atom of element X has the disposition to decay to an atom of element Y
example of usage: certain people have a predisposition to colon cancer
example of usage: children are innately disposed to categorize objects in certain ways.
example of usage: the cell wall is disposed to filter chemicals in endocytosis and exocytosis
editor note: BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.
imported from: mf.owl
imported from: mondo.owl
imported from: ogms.owl
elucidation: b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
has associated axiom(nl): If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
has associated axiom(fol): (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
has associated axiom(fol): (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]

Axiom
annotated source: disposition
annotated property: elucidation
annotated target: b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/062-002

Axiom
annotated source: disposition
annotated property: has associated axiom(nl)
annotated target: If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/063-002

Axiom
annotated source: disposition
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/063-002

Axiom
annotated source: disposition
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/062-002

realizable entity
type: Class
subclass of: specifically dependent continuant
disjoint with: quality
BFO OWL specification label: realizable
BFO CLIF specification label: RealizableEntity
example of usage: the disposition of this piece of metal to conduct electricity.
example of usage: the disposition of your blood to coagulate
example of usage: the function of your reproductive organs
example of usage: the role of being a doctor
example of usage: the role of this boundary to delineate where Utah and Colorado meet
definition: A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.
imported from: mondo.owl
elucidation: To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
has associated axiom(nl): All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
has associated axiom(fol): (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
has associated axiom(fol): (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]

Axiom
annotated source: realizable entity
annotated property: elucidation
annotated target: To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/058-002

Axiom
annotated source: realizable entity
annotated property: has associated axiom(nl)
annotated target: All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/060-002

Axiom
annotated source: realizable entity
annotated property: has associated axiom(fol)
annotated target: (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/060-002

Axiom
annotated source: realizable entity
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/058-002

zero-dimensional spatial region
type: Class
subclass of: spatial region
disjoint with: three-dimensional spatial region
BFO OWL specification label: 0d-s-region
BFO CLIF specification label: ZeroDimensionalSpatialRegion
elucidation: A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001])
has associated axiom(fol): (forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001]

Axiom
annotated source: zero-dimensional spatial region
annotated property: elucidation
annotated target: A zero-dimensional spatial region is a point in space. (axiom label in BFO2 Reference: [037-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/037-001

Axiom
annotated source: zero-dimensional spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ZeroDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [037-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/037-001

quality
type: Class
subclass of: specifically dependent continuant
BFO OWL specification label: quality
BFO CLIF specification label: Quality
example of usage: the ambient temperature of this portion of air
example of usage: the color of a tomato
example of usage: the length of the circumference of your waist
example of usage: the mass of this piece of gold.
example of usage: the shape of your nose
example of usage: the shape of your nostril
imported from: omit.owl
elucidation: a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
has associated axiom(nl): If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
has associated axiom(fol): (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
has associated axiom(fol): (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]

Axiom
annotated source: quality
annotated property: elucidation
annotated target: a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/055-001

Axiom
annotated source: quality
annotated property: has associated axiom(nl)
annotated target: If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/105-001

Axiom
annotated source: quality
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/055-001

Axiom
annotated source: quality
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/105-001

specifically dependent continuant
type: Class
subclass of: continuant
disjoint with: generically dependent continuant
BFO OWL specification label: sdc
BFO CLIF specification label: SpecificallyDependentContinuant
editor preferred label: specifically dependent continuant
example of usage: Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key
example of usage: of one-sided specifically dependent continuants: the mass of this tomato
example of usage: of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.
example of usage: the disposition of this fish to decay
example of usage: the function of this heart: to pump blood
example of usage: the mutual dependence of proton donors and acceptors in chemical reactions [79
example of usage: the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction
example of usage: the pink color of a medium rare piece of grilled filet mignon at its center
example of usage: the role of being a doctor
example of usage: the shape of this hole.
example of usage: the smell of this portion of mozzarella
definition: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
definition: b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])
definition: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
editor note: Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
imported from: mondo.owl
imported from: ons.owl
imported from: pato.owl
has associated axiom(fol): (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004]
has associated axiom(fol): (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]

Axiom
annotated source: specifically dependent continuant
annotated property: has associated axiom(fol)
annotated target: (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/050-003

Axiom
annotated source: specifically dependent continuant
annotated property: definition
annotated target: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/050-003

Axiom
annotated source: specifically dependent continuant
annotated property: editor note
annotated target: Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000005
comment: per discussion with Barry Smith

role
type: Class
subclass of: realizable entity
BFO OWL specification label: role
BFO CLIF specification label: Role
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
example of usage: the priest role
example of usage: the role of a boundary to demarcate two neighboring administrative territories
example of usage: the role of a building in serving as a military target
example of usage: the role of a stone in marking a property boundary
example of usage: the role of subject in a clinical trial
example of usage: the student role
editor note: BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives.
elucidation: b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
has associated axiom(fol): (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]

Axiom
annotated source: role
annotated property: elucidation
annotated target: b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/061-001

Axiom
annotated source: role
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/061-001

fiat object part
type: Class
subclass of: material entity
BFO OWL specification label: fiat-object-part
BFO CLIF specification label: FiatObjectPart
example of usage: or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29
example of usage: the FMA:regional parts of an intact human body.
example of usage: the Western hemisphere of the Earth
example of usage: the division of the brain into regions
example of usage: the division of the planet into hemispheres
example of usage: the dorsal and ventral surfaces of the body
example of usage: the upper and lower lobes of the left lung
editor note: BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions
elucidation: b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])
has associated axiom(fol): (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004]

Axiom
annotated source: fiat object part
annotated property: elucidation
annotated target: b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/027-004

Axiom
annotated source: fiat object part
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/027-004

one-dimensional spatial region
type: Class
subclass of: spatial region
disjoint with: three-dimensional spatial region
BFO OWL specification label: 1d-s-region
BFO CLIF specification label: OneDimensionalSpatialRegion
example of usage: an edge of a cube-shaped portion of space.
elucidation: A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001])
has associated axiom(fol): (forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001]

Axiom
annotated source: one-dimensional spatial region
annotated property: elucidation
annotated target: A one-dimensional spatial region is a line or aggregate of lines stretching from one point in space to another. (axiom label in BFO2 Reference: [038-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/038-001

Axiom
annotated source: one-dimensional spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (OneDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [038-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/038-001

object aggregate
type: Class
subclass of: material entity
BFO OWL specification label: object-aggregate
BFO CLIF specification label: ObjectAggregate
example of usage: a collection of cells in a blood biobank.
example of usage: a swarm of bees is an aggregate of members who are linked together through natural bonds
example of usage: a symphony orchestra
example of usage: an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team)
example of usage: defined by fiat: the aggregate of members of an organization
example of usage: defined through physical attachment: the aggregate of atoms in a lump of granite
example of usage: defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container
example of usage: defined via attributive delimitations such as: the patients in this hospital
example of usage: the aggregate of bearings in a constant velocity axle joint
example of usage: the aggregate of blood cells in your body
example of usage: the nitrogen atoms in the atmosphere
example of usage: the restaurants in Palo Alto
example of usage: your collection of Meissen ceramic plates.
editor note: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
editor note: BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee).
definition source: ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158.
elucidation: b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])
has associated axiom(fol): (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004]

Axiom
annotated source: object aggregate
annotated property: editor note
annotated target: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000011

Axiom
annotated source: object aggregate
annotated property: editor note
annotated target: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000301

Axiom
annotated source: object aggregate
annotated property: definition source
annotated target: ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000300

Axiom
annotated source: object aggregate
annotated property: elucidation
annotated target: b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/025-004

Axiom
annotated source: object aggregate
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/025-004

three-dimensional spatial region
type: Class
subclass of: spatial region
BFO OWL specification label: 3d-s-region
BFO CLIF specification label: ThreeDimensionalSpatialRegion
example of usage: a cube-shaped region of space
example of usage: a sphere-shaped region of space,
elucidation: A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])
has associated axiom(fol): (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001]

Axiom
annotated source: three-dimensional spatial region
annotated property: elucidation
annotated target: A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/040-001

Axiom
annotated source: three-dimensional spatial region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/040-001

site
type: Class
subclass of: immaterial entity
BFO OWL specification label: site
BFO CLIF specification label: Site
example of usage: Manhattan Canyon)
example of usage: a hole in the interior of a portion of cheese
example of usage: a rabbit hole
example of usage: an air traffic control region defined in the airspace above an airport
example of usage: the Grand Canyon
example of usage: the Piazza San Marco
example of usage: the cockpit of an aircraft
example of usage: the hold of a ship
example of usage: the interior of a kangaroo pouch
example of usage: the interior of the trunk of your car
example of usage: the interior of your bedroom
example of usage: the interior of your office
example of usage: the interior of your refrigerator
example of usage: the lumen of your gut
example of usage: your left nostril (a fiat part – the opening – of your left nasal cavity)
elucidation: b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
has associated axiom(fol): (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]

Axiom
annotated source: site
annotated property: elucidation
annotated target: b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/034-002

Axiom
annotated source: site
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/034-002

object
type: Class
subclass of: material entity
BFO OWL specification label: object
BFO CLIF specification label: Object
example of usage: atom
example of usage: cell
example of usage: cells and organisms
example of usage: engineered artifacts
example of usage: grain of sand
example of usage: molecule
example of usage: organelle
example of usage: organism
example of usage: planet
example of usage: solid portions of matter
example of usage: star
editor note: BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting.
editor note: BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below).
editor note: BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47
editor note: BFO 2 Reference: an object is a maximal causally unified material entity
editor note: BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74
elucidation: b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])

Axiom
annotated source: object
annotated property: elucidation
annotated target: b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/024-001

generically dependent continuant
type: Class
subclass of: continuant
BFO OWL specification label: gdc
BFO CLIF specification label: GenericallyDependentContinuant
example of usage: The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.
example of usage: the pdf file on your laptop, the pdf file that is a copy thereof on my laptop
example of usage: the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.
definition: b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
has associated axiom(fol): (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]

Axiom
annotated source: generically dependent continuant
annotated property: definition
annotated target: b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/074-001

Axiom
annotated source: generically dependent continuant
annotated property: has associated axiom(fol)
annotated target: (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/074-001

function
type: Class
subclass of: disposition
BFO OWL specification label: function
BFO CLIF specification label: Function
example of usage: the function of a hammer to drive in nails
example of usage: the function of a heart pacemaker to regulate the beating of a heart through electricity
example of usage: the function of amylase in saliva to break down starch into sugar
editor note: BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc.
elucidation: A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])
has associated axiom(fol): (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001]

Axiom
annotated source: function
annotated property: elucidation
annotated target: A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/064-001

Axiom
annotated source: function
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/064-001

process boundary
type: Class
subclass of: occurrent
BFO OWL specification label: p-boundary
BFO CLIF specification label: ProcessBoundary
example of usage: the boundary between the 2nd and 3rd year of your life.
definition: p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])
has associated axiom(nl): Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])
has associated axiom(fol): (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002]
has associated axiom(fol): (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001]

Axiom
annotated source: process boundary
annotated property: definition
annotated target: p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/084-001

Axiom
annotated source: process boundary
annotated property: has associated axiom(nl)
annotated target: Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/085-002

Axiom
annotated source: process boundary
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/085-002

Axiom
annotated source: process boundary
annotated property: has associated axiom(fol)
annotated target: (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/084-001

one-dimensional temporal region
type: Class
subclass of: temporal region
disjoint with: zero-dimensional temporal region
BFO OWL specification label: 1d-t-region
BFO CLIF specification label: OneDimensionalTemporalRegion
example of usage: the temporal region during which a process occurs.
editor note: BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks).
elucidation: A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
has associated axiom(fol): (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]

Axiom
annotated source: one-dimensional temporal region
annotated property: elucidation
annotated target: A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/103-001

Axiom
annotated source: one-dimensional temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/103-001

material entity
type: Class
subclass of: independent continuant
disjoint with: immaterial entity
BFO OWL specification label: material
BFO CLIF specification label: MaterialEntity
example of usage: a flame
example of usage: a forest fire
example of usage: a human being
example of usage: a hurricane
example of usage: a photon
example of usage: a puff of smoke
example of usage: a sea wave
example of usage: a tornado
example of usage: an aggregate of human beings.
example of usage: an energy wave
example of usage: an epidemic
example of usage: the undetached arm of a human being
editor note: BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60
editor note: BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.
editor note: BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.
imported from: ogg.owl
imported from: ogms.owl
imported from: uberon.owl
elucidation: A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
has associated axiom(nl): Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
has associated axiom(nl): every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
has associated axiom(fol): (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]
has_obo_namespace: bfo
id: BFO:0000040

Axiom
annotated source: material entity
annotated property: elucidation
annotated target: A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/019-002

Axiom
annotated source: material entity
annotated property: has associated axiom(nl)
annotated target: Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/020-002

Axiom
annotated source: material entity
annotated property: has associated axiom(nl)
annotated target: every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/021-002

Axiom
annotated source: material entity
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/019-002

Axiom
annotated source: material entity
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/021-002

Axiom
annotated source: material entity
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/020-002

continuant fiat boundary
type: Class
subclass of: immaterial entity
BFO OWL specification label: cf-boundary
BFO CLIF specification label: ContinuantFiatBoundary
definition: b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001])
editor note: BFO 2 Reference: In BFO 1.1 the assumption was made that the external surface of a material entity such as a cell could be treated as if it were a boundary in the mathematical sense. The new document propounds the view that when we talk about external surfaces of material objects in this way then we are talking about something fiat. To be dealt with in a future version: fiat boundaries at different levels of granularity.More generally, the focus in discussion of boundaries in BFO 2.0 is now on fiat boundaries, which means: boundaries for which there is no assumption that they coincide with physical discontinuities. The ontology of boundaries becomes more closely allied with the ontology of regions.
editor note: BFO 2 Reference: a continuant fiat boundary is a boundary of some material entity (for example: the plane separating the Northern and Southern hemispheres; the North Pole), or it is a boundary of some immaterial entity (for example of some portion of airspace). Three basic kinds of continuant fiat boundary can be distinguished (together with various combination kinds [29
editor note: Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions.
has associated axiom(nl): Every continuant fiat boundary is located at some spatial region at every time at which it exists
has associated axiom(fol): (iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001]

Axiom
annotated source: continuant fiat boundary
annotated property: definition
annotated target: b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/029-001

Axiom
annotated source: continuant fiat boundary
annotated property: editor note
annotated target: Continuant fiat boundary doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the mereological sum of two-dimensional continuant fiat boundary and a one dimensional continuant fiat boundary that doesn't overlap it. The situation is analogous to temporal and spatial regions.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000008

Axiom
annotated source: continuant fiat boundary
annotated property: has associated axiom(fol)
annotated target: (iff (ContinuantFiatBoundary a) (and (ImmaterialEntity a) (exists (b) (and (or (ZeroDimensionalSpatialRegion b) (OneDimensionalSpatialRegion b) (TwoDimensionalSpatialRegion b)) (forall (t) (locatedInAt a b t)))) (not (exists (c t) (and (SpatialRegion c) (continuantPartOfAt c a t)))))) // axiom label in BFO2 CLIF: [029-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/029-001

immaterial entity
type: Class
subclass of: independent continuant
BFO OWL specification label: immaterial
BFO CLIF specification label: ImmaterialEntity
editor note: BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10

one-dimensional continuant fiat boundary
type: Class
subclass of: continuant fiat boundary
disjoint with: two-dimensional continuant fiat boundary
disjoint with: zero-dimensional continuant fiat boundary
BFO OWL specification label: 1d-cf-boundary
BFO CLIF specification label: OneDimensionalContinuantFiatBoundary
example of usage: The Equator
example of usage: all geopolitical boundaries
example of usage: all lines of latitude and longitude
example of usage: the line separating the outer surface of the mucosa of the lower lip from the outer surface of the skin of the chin.
example of usage: the median sulcus of your tongue
elucidation: a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001])
has associated axiom(fol): (iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001]

Axiom
annotated source: one-dimensional continuant fiat boundary
annotated property: elucidation
annotated target: a one-dimensional continuant fiat boundary is a continuous fiat line whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [032-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/032-001

Axiom
annotated source: one-dimensional continuant fiat boundary
annotated property: has associated axiom(fol)
annotated target: (iff (OneDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (OneDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [032-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/032-001

process profile
type: Class
subclass of: process
BFO OWL specification label: process-profile
BFO CLIF specification label: ProcessProfile
example of usage: On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels
example of usage: One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance.
example of usage: The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on.
definition: b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])
elucidation: b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])
has associated axiom(fol): (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005]
has associated axiom(fol): (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002]

Axiom
annotated source: process profile
annotated property: definition
annotated target: b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/093-002

Axiom
annotated source: process profile
annotated property: elucidation
annotated target: b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/094-005

Axiom
annotated source: process profile
annotated property: has associated axiom(fol)
annotated target: (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/094-005

Axiom
annotated source: process profile
annotated property: has associated axiom(fol)
annotated target: (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/093-002

relational quality
type: Class
subclass of: quality
BFO OWL specification label: r-quality
BFO CLIF specification label: RelationalQuality
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
example of usage: a marriage bond, an instance of requited love, an obligation between one person and another.
definition: b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])
has associated axiom(fol): (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001]

Axiom
annotated source: relational quality
annotated property: definition
annotated target: b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/057-001

Axiom
annotated source: relational quality
annotated property: has associated axiom(fol)
annotated target: (iff (RelationalQuality a) (exists (b c t) (and (IndependentContinuant b) (IndependentContinuant c) (qualityOfAt a b t) (qualityOfAt a c t)))) // axiom label in BFO2 CLIF: [057-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/057-001

two-dimensional continuant fiat boundary
type: Class
subclass of: continuant fiat boundary
BFO OWL specification label: 2d-cf-boundary
BFO CLIF specification label: TwoDimensionalContinuantFiatBoundary
elucidation: a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001])
has associated axiom(fol): (iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001]

Axiom
annotated source: two-dimensional continuant fiat boundary
annotated property: elucidation
annotated target: a two-dimensional continuant fiat boundary (surface) is a self-connected fiat surface whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [033-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/033-001

Axiom
annotated source: two-dimensional continuant fiat boundary
annotated property: has associated axiom(fol)
annotated target: (iff (TwoDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (TwoDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [033-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/033-001

zero-dimensional continuant fiat boundary
type: Class
subclass of: continuant fiat boundary
BFO OWL specification label: 0d-cf-boundary
BFO CLIF specification label: ZeroDimensionalContinuantFiatBoundary
example of usage: the geographic North Pole
example of usage: the point of origin of some spatial coordinate system.
example of usage: the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet
editor note: zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona.
elucidation: a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001])
has associated axiom(fol): (iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001]

Axiom
annotated source: zero-dimensional continuant fiat boundary
annotated property: editor note
annotated target: zero dimension continuant fiat boundaries are not spatial points. Considering the example 'the quadripoint where the boundaries of Colorado, Utah, New Mexico, and Arizona meet' : There are many frames in which that point is zooming through many points in space. Whereas, no matter what the frame, the quadripoint is always in the same relation to the boundaries of Colorado, Utah, New Mexico, and Arizona.
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/0000001
comment: requested by Melanie Courtot

Axiom
annotated source: zero-dimensional continuant fiat boundary
annotated property: elucidation
annotated target: a zero-dimensional continuant fiat boundary is a fiat point whose location is defined in relation to some material entity. (axiom label in BFO2 Reference: [031-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/031-001

Axiom
annotated source: zero-dimensional continuant fiat boundary
annotated property: has associated axiom(fol)
annotated target: (iff (ZeroDimensionalContinuantFiatBoundary a) (and (ContinuantFiatBoundary a) (exists (b) (and (ZeroDimensionalSpatialRegion b) (forall (t) (locatedInAt a b t)))))) // axiom label in BFO2 CLIF: [031-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/031-001

zero-dimensional temporal region
type: Class
subclass of: temporal region
BFO OWL specification label: 0d-t-region
BFO CLIF specification label: ZeroDimensionalTemporalRegion
example of usage: a temporal region that is occupied by a process boundary
example of usage: right now
example of usage: the moment at which a child is born
example of usage: the moment at which a finger is detached in an industrial accident
example of usage: the moment of death.
alternative term: temporal instant.
elucidation: A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])
has associated axiom(fol): (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001]

Axiom
annotated source: zero-dimensional temporal region
annotated property: elucidation
annotated target: A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/102-001

Axiom
annotated source: zero-dimensional temporal region
annotated property: has associated axiom(fol)
annotated target: (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001]
IAO_0010000: http://purl.obolibrary.org/obo/bfo/axiom/102-001

cell culture
type: Class
subclass of: material entity
definition: Cells taken from a living organism and grown under controlled conditions (in culture). Methods used to maintain cell lines or strains.
imported from: bto.owl
has_obo_namespace: BrendaTissueOBO
id: BTO:0000214

macroglia
type: Class
subclass of: eukaryotic cell
definition: Neuroglial cells of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together. Originally, the term was used for the astrocytes alone.
imported from: bto.owl
has_obo_namespace: BrendaTissueOBO
has_related_synonym: macroglial cell
id: BTO:0000771

neuroblastoma cell line
type: Class
subclass of: In Vitro Model
imported from: bto.owl
has_obo_namespace: BrendaTissueOBO
has_related_synonym: NBL cell line
id: BTO:0000932

plant
type: Class
subclass of: material entity
definition: Any of a kingdom (Plantae) of living things typically lacking locomotive movement or obvious nervous or sensory organs and possessing cellulose cell walls.
imported from: bto.owl
has_obo_namespace: BrendaTissueOBO
has_related_synonym: Pflanze
has_related_synonym: plantae
has_related_synonym: viridiplantae
id: BTO:0001481

Neuro-2a cell
type: Class
subclass of: neuroblastoma cell line
definition: Mus musculus (mouse) brain neuroblastoma cell line. Clone Neuro-2a was established by R.J. Klebe and F.H. Ruddle from a spontaneous tumor of a strain A albino mouse.
imported from: bto.owl
has_obo_namespace: BrendaTissueOBO
has_related_synonym: N-2a cell
has_related_synonym: N2A cell
has_related_synonym: N2a cell
has_related_synonym: N2alpha cell
has_related_synonym: NB-2a cell
has_related_synonym: NB2a cell
has_related_synonym: NEURO-2A cell
has_related_synonym: Nb2a cell
has_related_synonym: Neuro 2A cell
has_related_synonym: Neuro2A cell
has_related_synonym: Neuro2a cell
id: BTO:0001976

dentate gyrus
type: Class
subclass of: Hippocampus
definition: A serrated strip of gray matter under the medial border of the hippocampus and in its depths; it is an archaeocortex which develops along the edge of the hippocampal fissure and which consists of molecular, granular, and polymorphic layers.
imported from: bto.owl
has_obo_namespace: BrendaTissueOBO
has_related_synonym: gyrus dentatus
has_related_synonym: hippocampal dentate gyrus
id: BTO:0002496

amyloid plaque
type: Class
subclass of: Abnormal nervous system morphology
subclass of: Restriction
  on property: isClinicalMarkerFor
  some values from: Alzheimer's disease
definition: A plaque consisting of tangles of amyloid protein in nervous tissue (a pathological mark of Alzheimer's disease).
imported from: bto.owl
has_obo_namespace: BrendaTissueOBO
id: BTO:0002774

medial temporal lobe
type: Class
subclass of: cerebral cortex
definition: The medial temporal lobes are near the Sagittal plane that divides left and right cerebral hemispheres and are thought to be involved in episodic, declarative memory.
imported from: bto.owl
created by: Marion
creation date: 2010-02-04T10:57:44Z
has_obo_namespace: BrendaTissueOBO
id: BTO:0004477

ziprasidone
type: Class
subclass of: antipsychotic agent
definition: A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.
imported from: chebi.owl
charge: 0
formula: C21H21ClN4OS
inchi: InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)
inchikey: MVWVFYHBGMAFLY-UHFFFAOYSA-N
mass: 412.93600
monoisotopicmass: 412.11246
database cross reference: Beilstein:6669199
database cross reference: CAS:146939-27-7
database cross reference: DrugBank:DB00246
database cross reference: Drug_Central:2865
database cross reference: KEGG:C07568
database cross reference: KEGG:D08687
database cross reference: LINCS:LSM-5433
database cross reference: Patent:EP281309
database cross reference: Patent:US4831031
database cross reference: Wikipedia:Ziprasidone
has exact synonym: 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
has exact synonym: Ziprasidone
has_obo_namespace: chebi_ontology
has_related_synonym: ziprasidona
has_related_synonym: ziprasidone
has_related_synonym: ziprasidonum
id: CHEBI:10119
in subset: 3 STAR

vitamin A
type: Class
subclass of: lipid
definition: Any member of a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids that exhibit biological activity against vitamin A deficiency. Vitamin A is involved in immune function, vision, reproduction, and cellular communication.
imported from: chebi.owl
database cross reference: MetaCyc:Vitamin-A
database cross reference: Wikipedia:Vitamin_A
has_obo_namespace: chebi_ontology
has_related_synonym: vitamin A vitamer
has_related_synonym: vitamin A vitamers
has_related_synonym: vitamin-A
has_related_synonym: vitamins A
id: CHEBI:12777
in subset: 3 STAR

docosanoid
type: Class
subclass of: fatty acid
definition: Any oxygenated derivative of C22 polyunsaturated fatty acids, such as docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: docosanoids
id: CHEBI:131863
in subset: 3 STAR

reboxetine
type: Class
subclass of: ether
imported from: chebi.owl
charge: 0
formula: C19H23NO3
inchi: InChI=1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3/t18-,19-/m1/s1
inchikey: CBQGYUDMJHNJBX-RTBURBONSA-N
mass: 313.392
monoisotopicmass: 313.16779
database cross reference: CAS:71620-89-8
database cross reference: Drug_Central:2361
has_obo_namespace: chebi_ontology
has_related_synonym: edronax
has_related_synonym: norebox
has_related_synonym: reboxetine mesilate
has_related_synonym: reboxetine mesylate
has_related_synonym: reboxitine
id: CHEBI:135342
in subset: 2 STAR

spirapril
type: Class
subclass of: organosulfur compound
subclass of: organonitrogen compound
subclass of: organic molecule
imported from: chebi.owl
charge: 0
formula: C22H30N2O5S2
inchi: InChI=1S/C22H30N2O5S2/c1-3-29-21(28)17(10-9-16-7-5-4-6-8-16)23-15(2)19(25)24-14-22(30-11-12-31-22)13-18(24)20(26)27/h4-8,15,17-18,23H,3,9-14H2,1-2H3,(H,26,27)/t15-,17-,18-/m0/s1
inchikey: HRWCVUIFMSZDJS-SZMVWBNQSA-N
mass: 466.617
monoisotopicmass: 466.15961
database cross reference: CAS:83647-97-6
database cross reference: DrugBank:DB01348
database cross reference: Drug_Central:2474
database cross reference: HMDB:HMDB0015438
database cross reference: KEGG:D08529
database cross reference: PMID:10499560
database cross reference: PMID:10499561
database cross reference: PMID:12613273
database cross reference: PMID:8638865
database cross reference: PMID:9345854
database cross reference: Reaxys:4277924
database cross reference: Wikipedia:Spirapril
has exact synonym: (8S)-7-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
has_obo_namespace: chebi_ontology
id: CHEBI:135756
in subset: 2 STAR

acetoacetate
type: Class
subclass of: lipid
definition: A 3-oxo monocarboxylic acid anion that is the conjugate base of acetoacetic acid, arising from deprotonation of the carboxy group.
imported from: chebi.owl
charge: -1
formula: C4H5O3
inchi: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1
inchikey: WDJHALXBUFZDSR-UHFFFAOYSA-M
mass: 101.08070
monoisotopicmass: 101.02442
smiles: CC(=O)CC([O-])=O
database cross reference: Beilstein:4128534
database cross reference: CAS:141-81-1
database cross reference: KEGG:C00164
database cross reference: MetaCyc:3-KETOBUTYRATE
database cross reference: Reaxys:4128534
database cross reference: UM-BBD_compID:c0069
has exact synonym: 3-oxobutanoate
has exact synonym: Acetoacetate
has exact synonym: acetoacetate
has_obo_namespace: chebi_ontology
has_related_synonym: Acetoacetate ion(1-)
has_related_synonym: Butanoic acid, 3-oxo-, ion(1-)
id: CHEBI:13705
in subset: 3 STAR

protectin D1
type: Class
subclass of: carbon group molecular entity
subclass of: organic hydroxy compound
subclass of: Restriction
  on property: positively regulates
  some values from: ADAM10
definition: A dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13E,15Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10R,17S-stereoisomer). Protectin D1 is one of the specialised proresolving mediators. When produced in neural tissues, it is called neuroprotectin D1
imported from: chebi.owl
charge: 0
formula: C22H32O4
inchi: InChI=1S/C22H32O4/c1-2-3-10-15-20(23)17-12-8-9-13-18-21(24)16-11-6-4-5-7-14-19-22(25)26/h3,5-13,17-18,20-21,23-24H,2,4,14-16,19H2,1H3,(H,25,26)/b7-5-,9-8+,10-3-,11-6-,17-12-,18-13+/t20-,21+/m0/s1
inchikey: CRDZYJSQHCXHEG-SFVBTVKNSA-N
mass: 360.488
monoisotopicmass: 360.23006
smiles: OC(CC/C=C\C/C=C\C[C@H](\C=C\C=C\C=C/[C@H](C/C=C\CC)O)O)=O
relation: Alzpathway: NPD1 leading to ADAM10; Source: https://pubmed.ncbi.nlm.nih.gov/21431475/
database cross reference: HMDB:HMDB0003689
database cross reference: PMID:22690022
database cross reference: PMID:23686636
database cross reference: PMID:23799606
database cross reference: PMID:24107502
database cross reference: PMID:24262603
database cross reference: PMID:24520010
database cross reference: PMID:25139562
database cross reference: PMID:25617763
database cross reference: PMID:26047923
database cross reference: PMID:26427436
database cross reference: PMID:26580578
database cross reference: PMID:26955849
database cross reference: PMID:27632672
database cross reference: PMID:27866493
database cross reference: PMID:27988338
database cross reference: PMID:28109294
database cross reference: PMID:28429196
database cross reference: PMID:28430183
database cross reference: PMID:28615451
database cross reference: PMID:29177613
database cross reference: Reaxys:18351330
database cross reference: Wikipedia:Protectin_D1
has exact synonym: (4Z,7Z,10R,11E,13E,15Z,17S,19Z)-10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (4Z,7Z,10R,11E,13E,15Z,17S,19Z)-10,17-dihydroxydocosahexaenoic acid
has_related_synonym: (N)PD1
has_related_synonym: (neuro)protectin D1
has_related_synonym: 10(R),17(S)-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid
has_related_synonym: NPD1
has_related_synonym: PD1
has_related_synonym: neuroprotectin D1
id: CHEBI:138655
in subset: 3 STAR

secondary carboxamide
type: Class
subclass of: carboxamide
definition: A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1).
imported from: chebi.owl
charge: 0
formula: CHNOR2
mass: 43.025
monoisotopicmass: 43.00581
smiles: N(C(*)=O)(*)[H]
has_obo_namespace: chebi_ontology
has_related_synonym: secondary carboxamides
id: CHEBI:140325
in subset: 3 STAR

4-hydroxynonenal
type: Class
subclass of: chalcogen molecular entity
subclass of: carbon group molecular entity
subclass of: polyatomic entity
definition: A monounsaturated fatty aldehyde that is nonanal that has undergone dehydrogenation to introduce a double bond at any position in the aliphatic chain and in which a hydrogen at position 4 has been replaced by a hydroxy group.
imported from: chebi.owl
charge: 0
formula: C9H16O2
mass: 156.222
monoisotopicmass: 156.11503
smiles: *C([H])=O
database cross reference: PMID:15865448
has_obo_namespace: chebi_ontology
has_related_synonym: a 4-hydroxynonenal
id: CHEBI:142593
in subset: 3 STAR

insulin
type: Class
subclass of: polypeptide
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
definition: A peptide hormone which consists of two polypeptide chains, A- and B- chains which are linked together by disulfide bonds. The amino acid sequence of insulin varies across species and certain segments of the molecule are highly conserved. In most species, the A chain consists of 21 amino acids and the B chain consists of 30 amino acids. In mammals, insulin is synthesised in the pancreas within the beta cells whereas in certain species of fish, the insulin-producing tissue is uniquely located in separate structures called Brockmann bodies.
imported from: chebi.owl
database cross reference: PMID:12137720
database cross reference: PMID:19251032
database cross reference: PMID:25848166
database cross reference: PMID:5941964
database cross reference: PMID:6069707
database cross reference: Wikipedia:Insulin
has_obo_namespace: chebi_ontology
id: CHEBI:145810
in subset: 3 STAR

acetoacetyl-CoA
type: Class
subclass of: lipid
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
subclass of: ester
subclass of: polyatomic entity
definition: A 3-oxoacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of acetoacetic acid.
imported from: chebi.owl
charge: 0
formula: C25H40N7O18P3S
inchikey: OJFDKHTZOUZBOS-CITAKDKDSA-N
mass: 851.610
monoisotopicmass: 851.13634
has_alternative_id: CHEBI:11756
has_alternative_id: CHEBI:13706
has_alternative_id: CHEBI:22173
has_alternative_id: CHEBI:2392
has_alternative_id: CHEBI:41333
database cross reference: CAS:1420-36-6
database cross reference: DrugBank:DB03059
database cross reference: FooDB:FDB022648
database cross reference: HMDB:HMDB0001484
database cross reference: KEGG:C00332
database cross reference: KNApSAcK:C00007269
database cross reference: LIPID_MAPS_instance:LMFA07050030
database cross reference: PDBeChem:CAA
database cross reference: PMID:10806397
database cross reference: PMID:11137815
database cross reference: PMID:11451959
database cross reference: PMID:12501183
database cross reference: PMID:1682408
database cross reference: PMID:16887802
database cross reference: PMID:239468
database cross reference: PMID:24211201
database cross reference: PMID:26527136
database cross reference: PMID:27093562
database cross reference: PMID:27124816
database cross reference: PMID:28062645
database cross reference: PMID:29226071
database cross reference: PMID:32218776
database cross reference: PMID:6118268
database cross reference: PMID:6150478
database cross reference: PMID:7857927
database cross reference: Reaxys:78273
database cross reference: UM-BBD_compID:c0229
database cross reference: Wikipedia:Acetoacetyl-CoA
has exact synonym: 3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxobutanoyl)sulfanyl]ethyl}amino)propyl]amino}butyl] dihydrogen diphosphate}
has exact synonym: Acetoacetyl-CoA
has_obo_namespace: chebi_ontology
has_related_synonym: 3-Acetoacetyl-CoA
has_related_synonym: Acetoacetyl coenzyme A
has_related_synonym: S-Acetoacetyl-coenzym A
has_related_synonym: S-acetoacetyl-CoA
has_related_synonym: S-acetoacetyl-coenzyme A
has_related_synonym: acetoacetyl CoA
id: CHEBI:15345
in subset: 3 STAR

coenzyme A
type: Class
subclass of: ester
definition: A thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit.
imported from: chebi.owl
charge: 0
formula: C21H36N7O16P3S
inchikey: RGJOEKWQDUBAIZ-IBOSZNHHSA-N
mass: 767.53540
monoisotopicmass: 767.11521
has_alternative_id: CHEBI:13294
has_alternative_id: CHEBI:13295
has_alternative_id: CHEBI:13298
has_alternative_id: CHEBI:23355
has_alternative_id: CHEBI:3771
has_alternative_id: CHEBI:41597
has_alternative_id: CHEBI:41631
has_alternative_id: CHEBI:741566
database cross reference: Beilstein:77809
database cross reference: CAS:85-61-0
database cross reference: DrugBank:DB01992
database cross reference: KEGG:C00010
database cross reference: KNApSAcK:C00007258
database cross reference: PDBeChem:COA
database cross reference: PDBeChem:COZ
database cross reference: PMID:11923312
database cross reference: PMID:13025483
database cross reference: PMID:15014152
database cross reference: PMID:15893380
database cross reference: PMID:18407920
database cross reference: PMID:19666462
database cross reference: PMID:20351285
database cross reference: PMID:2981478
database cross reference: PMID:7310833
database cross reference: Wikipedia:Coenzyme_A
has exact synonym: 3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl] dihydrogen diphosphate}
has exact synonym: COENZYME A
has exact synonym: Coenzyme A
has_obo_namespace: chebi_ontology
has_related_synonym: 3'-phosphoadenosine-(5')diphospho(4')pantatheine
has_related_synonym: CoA
has_related_synonym: CoA-SH
has_related_synonym: CoASH
has_related_synonym: Coenzym A
has_related_synonym: HSCoA
has_related_synonym: Koenzym A
has_related_synonym: [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate
id: CHEBI:15346
in subset: 3 STAR

acetyl-CoA
type: Class
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
subclass of: polyatomic entity
definition: An acyl-CoA having acetyl as its S-acetyl component.
imported from: chebi.owl
charge: 0
formula: C23H38N7O17P3S
inchikey: ZSLZBFCDCINBPY-ZSJPKINUSA-N
mass: 809.57208
monoisotopicmass: 809.12577
has_alternative_id: CHEBI:13712
has_alternative_id: CHEBI:22192
has_alternative_id: CHEBI:2408
has_alternative_id: CHEBI:40470
database cross reference: CAS:72-89-9
database cross reference: ECMDB:ECMDB01206
database cross reference: HMDB:HMDB0001206
database cross reference: KEGG:C00024
database cross reference: KNApSAcK:C00007259
database cross reference: PDBeChem:ACO
database cross reference: PMID:12527305
database cross reference: PMID:12739170
database cross reference: PMID:15247244
database cross reference: PMID:16101314
database cross reference: PMID:16667687
database cross reference: PMID:16708165
database cross reference: PMID:17189273
database cross reference: PMID:17242360
database cross reference: PMID:17631502
database cross reference: PMID:18613815
database cross reference: PMID:19356710
database cross reference: PMID:19596230
database cross reference: PMID:19914586
database cross reference: PMID:3950616
database cross reference: Reaxys:78145
database cross reference: UM-BBD_compID:c0031
database cross reference: Wikipedia:Acetyl-CoA
database cross reference: YMDB:YMDB00312
has exact synonym: 3'-phosphoadenosine 5'-(3-{(3R)-4-[(3-{[2-(acetylsulfanyl)ethyl]amino}-3-oxopropyl)amino]-3-hydroxy-2,2-dimethyl-4-oxobutyl} dihydrogen diphosphate)
has exact synonym: Acetyl-CoA
has_obo_namespace: chebi_ontology
has_related_synonym: AcCoA
has_related_synonym: Acetyl coenzyme A
has_related_synonym: S-acetyl-CoA
has_related_synonym: S-acetyl-coenzyme A
id: CHEBI:15351
in subset: 3 STAR

choline
type: Class
subclass of: ion
subclass of: pnictogen molecular entity
subclass of: carbon group molecular entity
subclass of: polyatomic entity
definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
imported from: chebi.owl
charge: +1
formula: C5H14NO
inchi: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1
inchikey: OEYIOHPDSNJKLS-UHFFFAOYSA-N
mass: 104.17080
monoisotopicmass: 104.10699
smiles: C[N+](C)(C)CCO
has_alternative_id: CHEBI:13985
has_alternative_id: CHEBI:23212
has_alternative_id: CHEBI:3665
has_alternative_id: CHEBI:41524
database cross reference: Beilstein:1736748
database cross reference: CAS:62-49-7
database cross reference: DrugBank:DB00122
database cross reference: Drug_Central:3097
database cross reference: ECMDB:ECMDB00097
database cross reference: Gmelin:324597
database cross reference: HMDB:HMDB0000097
database cross reference: KEGG:C00114
database cross reference: KEGG:D07690
database cross reference: KNApSAcK:C00007298
database cross reference: MetaCyc:CHOLINE
database cross reference: PDBeChem:CHT
database cross reference: PMID:10930630
database cross reference: PMID:12826235
database cross reference: PMID:12946691
database cross reference: PMID:14972364
database cross reference: PMID:16210714
database cross reference: PMID:17087106
database cross reference: PMID:17283071
database cross reference: PMID:17344490
database cross reference: PMID:18204095
database cross reference: PMID:18230680
database cross reference: PMID:18786517
database cross reference: PMID:18786520
database cross reference: PMID:19246089
database cross reference: PMID:20038853
database cross reference: PMID:20446114
database cross reference: PMID:22770225
database cross reference: PMID:22961562
database cross reference: PMID:23095202
database cross reference: PMID:23616508
database cross reference: PMID:23637565
database cross reference: PMID:23733158
database cross reference: PMID:6420466
database cross reference: PMID:7590654
database cross reference: PMID:9517478
database cross reference: Reaxys:1736748
database cross reference: Wikipedia:Choline
database cross reference: YMDB:YMDB00227
has exact synonym: 2-hydroxy-N,N,N-trimethylethanaminium
has exact synonym: Choline
has exact synonym: choline
has_obo_namespace: chebi_ontology
has_related_synonym: Bilineurine
has_related_synonym: CHOLINE ION
has_related_synonym: N,N,N-trimethylethanol-ammonium
has_related_synonym: N-trimethylethanolamine
has_related_synonym: trimethylethanolamine
id: CHEBI:15354
in subset: 3 STAR

acetylcholine
type: Class
subclass of: ion
subclass of: organic molecule
definition: Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
imported from: chebi.owl
charge: +1
formula: C7H16NO2
inchi: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
inchikey: OIPILFWXSMYKGL-UHFFFAOYSA-N
mass: 146.20748
monoisotopicmass: 146.11756
smiles: CC(=O)OCC[N+](C)(C)C
has_alternative_id: CHEBI:12686
has_alternative_id: CHEBI:13715
has_alternative_id: CHEBI:22197
has_alternative_id: CHEBI:2416
has_alternative_id: CHEBI:40559
database cross reference: Beilstein:1764436
database cross reference: CAS:51-84-3
database cross reference: DrugBank:DB03128
database cross reference: Drug_Central:65
database cross reference: Gmelin:326108
database cross reference: KEGG:C01996
database cross reference: LINCS:LSM-5888
database cross reference: PDBeChem:ACH
database cross reference: PMID:14764638
database cross reference: PMID:15014918
database cross reference: PMID:15231705
database cross reference: PMID:15361288
database cross reference: PMID:18050502
database cross reference: PMID:18407448
database cross reference: PMID:19255787
database cross reference: PMID:20963497
database cross reference: PMID:21130809
database cross reference: PMID:21246223
database cross reference: PMID:21545631
database cross reference: PMID:21601579
database cross reference: Wikipedia:Acetylcholine
has exact synonym: 2-acetyloxy-N,N,N-trimethylethanaminium
has exact synonym: ACETYLCHOLINE
has exact synonym: Acetylcholine
has exact synonym: acetylcholine
has_obo_namespace: chebi_ontology
has_related_synonym: ACh
has_related_synonym: Azetylcholin
has_related_synonym: O-Acetylcholine
has_related_synonym: choline acetate
id: CHEBI:15355
in subset: 3 STAR

cysteine
type: Class
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
subclass of: polyatomic entity
definition: A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.
imported from: chebi.owl
charge: 0
formula: C3H7NO2S
inchi: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)
inchikey: XUJNEKJLAYXESH-UHFFFAOYSA-N
mass: 121.15922
monoisotopicmass: 121.01975
smiles: NC(CS)C(O)=O
has_alternative_id: CHEBI:14061
has_alternative_id: CHEBI:23508
has_alternative_id: CHEBI:4050
database cross reference: Beilstein:1721406
database cross reference: CAS:3374-22-9
database cross reference: Gmelin:2933
database cross reference: KEGG:C00736
database cross reference: KNApSAcK:C00001351
database cross reference: KNApSAcK:C00007323
database cross reference: PMID:17439666
database cross reference: PMID:25181601
database cross reference: Reaxys:1721406
database cross reference: Wikipedia:Cysteine
has exact synonym: Cysteine
has exact synonym: cysteine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Amino-3-mercaptopropionic acid
has_related_synonym: 2-amino-3-mercaptopropanoic acid
has_related_synonym: 2-amino-3-sulfanylpropanoic acid
has_related_synonym: C
has_related_synonym: Cys
has_related_synonym: Cystein
has_related_synonym: Hcys
has_related_synonym: Zystein
has_related_synonym: cisteina
id: CHEBI:15356
in subset: 3 STAR

pyruvate
type: Class
subclass of: chalcogen molecular entity
subclass of: carbon group molecular entity
subclass of: polyatomic entity
definition: A 2-oxo monocarboxylic acid anion that is the conjugate base of pyruvic acid, arising from deprotonation of the carboxy group.
imported from: chebi.owl
charge: -1
formula: C3H3O3
inchi: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1
inchikey: LCTONWCANYUPML-UHFFFAOYSA-M
mass: 87.05412
monoisotopicmass: 87.00877
smiles: CC(=O)C([O-])=O
has_alternative_id: CHEBI:14987
has_alternative_id: CHEBI:26462
database cross reference: Beilstein:3587721
database cross reference: CAS:57-60-3
database cross reference: Gmelin:2502
database cross reference: KEGG:C00022
database cross reference: PMID:17190852
database cross reference: PMID:21603897
database cross reference: PMID:21823181
database cross reference: PMID:21854850
database cross reference: PMID:22006570
database cross reference: PMID:22016370
database cross reference: PMID:22215378
database cross reference: PMID:22311625
database cross reference: PMID:22451307
database cross reference: PMID:22458763
database cross reference: Reaxys:3587721
database cross reference: UM-BBD_compID:c0159
has exact synonym: 2-oxopropanoate
has exact synonym: pyruvate
has_obo_namespace: chebi_ontology
has_related_synonym: 2-oxopropanoate
has_related_synonym: 2-oxopropanoic acid, ion(1-)
id: CHEBI:15361
in subset: 3 STAR

water
type: Class
subclass of: chalcogen molecular entity
subclass of: polyatomic entity
definition: An oxygen hydride consisting of an oxygen atom that is covalently bonded to two hydrogen atoms.
imported from: chebi.owl
charge: 0
formula: H2O
inchi: InChI=1S/H2O/h1H2
inchikey: XLYOFNOQVPJJNP-UHFFFAOYSA-N
mass: 18.01530
monoisotopicmass: 18.01056
smiles: [H]O[H]
has_alternative_id: CHEBI:10743
has_alternative_id: CHEBI:13352
has_alternative_id: CHEBI:27313
has_alternative_id: CHEBI:42043
has_alternative_id: CHEBI:42857
has_alternative_id: CHEBI:43228
has_alternative_id: CHEBI:44292
has_alternative_id: CHEBI:44701
has_alternative_id: CHEBI:44819
has_alternative_id: CHEBI:5585
database cross reference: Beilstein:3587155
database cross reference: CAS:7732-18-5
database cross reference: Gmelin:117
database cross reference: HMDB:HMDB0002111
database cross reference: KEGG:C00001
database cross reference: KEGG:D00001
database cross reference: MetaCyc:WATER
database cross reference: MolBase:1
database cross reference: PDBeChem:HOH
database cross reference: Reaxys:3587155
database cross reference: Wikipedia:Water
has exact synonym: WATER
has exact synonym: Water
has exact synonym: oxidane
has exact synonym: water
has_obo_namespace: chebi_ontology
has_related_synonym: BOUND WATER
has_related_synonym: H2O
has_related_synonym: HOH
has_related_synonym: Wasser
has_related_synonym: [OH2]
has_related_synonym: acqua
has_related_synonym: agua
has_related_synonym: aqua
has_related_synonym: dihydridooxygen
has_related_synonym: dihydrogen oxide
has_related_synonym: eau
has_related_synonym: hydrogen hydroxide
id: CHEBI:15377
in subset: 3 STAR

succinyl-CoA
type: Class
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
subclass of: polyatomic entity
definition: An omega-carboxyacyl-CoA having succinoyl as the S-acyl component.
imported from: chebi.owl
charge: 0
formula: C25H40N7O19P3S
inchikey: VNOYUJKHFWYWIR-ITIYDSSPSA-N
mass: 867.60816
monoisotopicmass: 867.13125
has_alternative_id: CHEBI:10746
has_alternative_id: CHEBI:15127
has_alternative_id: CHEBI:26811
has_alternative_id: CHEBI:45541
has_alternative_id: CHEBI:9310
database cross reference: CAS:604-98-8
database cross reference: DrugBank:DB03699
database cross reference: KEGG:C00091
database cross reference: KNApSAcK:C00019546
database cross reference: PDBeChem:SCA
database cross reference: PMID:15627487
database cross reference: PMID:17259607
database cross reference: PMID:38930
database cross reference: PMID:7462221
database cross reference: Reaxys:78365
database cross reference: UM-BBD_compID:c0344
has exact synonym: 3'-phosphoadenosine 5'-{3-[(3R)-4-{[3-({2-[(3-carboxypropanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl] dihydrogen diphosphate}
has exact synonym: Succinyl-CoA
has exact synonym: succinyl-CoA
has_obo_namespace: chebi_ontology
has_related_synonym: Coenzyme A, S-(hydrogen butanedioate)
has_related_synonym: S-(3-Carboxy-propionyl)-coenzym-A
has_related_synonym: S-(3-carboxy-propionyl)-CoA
has_related_synonym: S-(3-carboxypropionyl)-coenzyme-A
has_related_synonym: S-(Hydrogen succinyl)coenzyme A
has_related_synonym: S-(hydrogen succinyl)-CoA
has_related_synonym: SUCCINYL-COENZYME A
has_related_synonym: Succinyl coenzyme A
has_related_synonym: Succinyl-coenzyme A
id: CHEBI:15380
in subset: 3 STAR

squalene
type: Class
subclass of: alkali metal molecular entity
definition: A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration.
imported from: chebi.owl
charge: 0
formula: C30H50
inchi: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+
inchikey: YYGNTYWPHWGJRM-AAJYLUCBSA-N
mass: 410.730
monoisotopicmass: 410.39125
smiles: CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C=C(/C)CC\C=C(/C)CCC=C(C)C
has_alternative_id: CHEBI:10795
has_alternative_id: CHEBI:10843
has_alternative_id: CHEBI:15104
has_alternative_id: CHEBI:26746
has_alternative_id: CHEBI:9245
database cross reference: Beilstein:1728920
database cross reference: CAS:111-02-4
database cross reference: HMDB:HMDB0000256
database cross reference: KEGG:C00751
database cross reference: KNApSAcK:C00003755
database cross reference: LIPID_MAPS_instance:LMPR0106010002
database cross reference: MetaCyc:SQUALENE
database cross reference: PDBeChem:SQL
database cross reference: PMID:16341241
database cross reference: PMID:23625688
database cross reference: PMID:24362891
database cross reference: PMID:25286851
database cross reference: PMID:25286853
database cross reference: PMID:25987292
database cross reference: Wikipedia:Squalene
has exact synonym: (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene
has exact synonym: Squalene
has exact synonym: squalene
has_obo_namespace: chebi_ontology
has_related_synonym: (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene
has_related_synonym: Spinacene
has_related_synonym: Supraene
id: CHEBI:15440
in subset: 3 STAR

prostaglandin E2
type: Class
subclass of: lipid
subclass of: chalcogen molecular entity
subclass of: organic hydroxy compound
definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
imported from: chebi.owl
charge: 0
formula: C20H32O5
inchi: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
inchikey: XEYBRNLFEZDVAW-ARSRFYASSA-N
mass: 352.471
monoisotopicmass: 352.22497
has_alternative_id: CHEBI:10910
has_alternative_id: CHEBI:10911
has_alternative_id: CHEBI:114125
has_alternative_id: CHEBI:26323
has_alternative_id: CHEBI:4625
has_alternative_id: CHEBI:8512
database cross reference: Beilstein:2224724
database cross reference: CAS:363-24-6
database cross reference: DrugBank:DB00917
database cross reference: Drug_Central:913
database cross reference: FooDB:FDB022498
database cross reference: HMDB:HMDB0001220
database cross reference: KEGG:C00584
database cross reference: KEGG:D00079
database cross reference: LINCS:LSM-42919
database cross reference: LIPID_MAPS_instance:LMFA03010003
database cross reference: PDBeChem:P2E
database cross reference: PMID:11279302
database cross reference: PMID:12746806
database cross reference: PMID:12859290
database cross reference: PMID:14499495
database cross reference: PMID:14535055
database cross reference: PMID:14703707
database cross reference: PMID:15542928
database cross reference: PMID:15661432
database cross reference: PMID:16405508
database cross reference: PMID:16787416
database cross reference: PMID:16978535
database cross reference: PMID:20671299
database cross reference: PMID:2403792
database cross reference: PMID:24501112
database cross reference: PMID:32898608
database cross reference: PMID:33271839
database cross reference: PMID:33559528
database cross reference: PMID:33685091
database cross reference: PMID:33715333
database cross reference: PMID:33782420
database cross reference: PMID:33811074
database cross reference: PMID:33958485
database cross reference: PMID:34065827
database cross reference: PMID:34071686
database cross reference: PMID:34102274
database cross reference: PMID:6317292
database cross reference: PMID:7224729
database cross reference: PMID:74611
database cross reference: PMID:7836930
database cross reference: PMID:9276764
database cross reference: Patent:DE2011969
database cross reference: Patent:GB851827
database cross reference: Patent:NL6505799
database cross reference: Patent:US3598858
database cross reference: Reaxys:2224724
database cross reference: Wikipedia:Prostaglandin_E2
has exact synonym: (5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
has exact synonym: Prostaglandin E2
has_obo_namespace: chebi_ontology
has_related_synonym: (15S)-prostaglandin E2
has_related_synonym: (5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
has_related_synonym: (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
has_related_synonym: (5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate
has_related_synonym: (E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid
has_related_synonym: (Z)-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid
has_related_synonym: Cervidil
has_related_synonym: Cerviprime
has_related_synonym: Cerviprost
has_related_synonym: Dinoproston
has_related_synonym: Enzaprost E
has_related_synonym: Glandin-E2

prostaglandin H2
type: Class
subclass of: fatty acid
imported from: chebi.owl
charge: 0
formula: C20H32O5
inchi: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
inchikey: YIBNHAJFJUQSRA-YNNPMVKQSA-N
mass: 352.46508
monoisotopicmass: 352.22497
has_alternative_id: CHEBI:10914
has_alternative_id: CHEBI:14909
has_alternative_id: CHEBI:26330
has_alternative_id: CHEBI:8520
database cross reference: Beilstein:1598632
database cross reference: CAS:42935-17-1
database cross reference: KEGG:C00427
database cross reference: LIPID_MAPS_instance:LMFA03010010
has exact synonym: (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
has exact synonym: (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoic acid
has exact synonym: Prostaglandin H2
has_obo_namespace: chebi_ontology
has_related_synonym: (5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate
has_related_synonym: (5Z,13E,15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate
has_related_synonym: (5Z,9alpha,11alpha,13E,15S)-9,11-epidioxy-15-hydroxyprosta-5,13-dien-1-oic acid
has_related_synonym: 9,11-Epoxymethano-pgh2
has_related_synonym: PGH2
id: CHEBI:15554
in subset: 3 STAR

5-methyltetrahydrofolic acid
type: Class
subclass of: vitamin B9
imported from: chebi.owl
charge: 0
formula: C20H25N7O6
inchi: InChI=1S/C20H25N7O6/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31)/t12-,13-/m0/s1
inchikey: ZNOVTXRBGFNYRX-STQMWFEESA-N
mass: 459.45580
monoisotopicmass: 459.18663
has_alternative_id: CHEBI:12146
has_alternative_id: CHEBI:2097
database cross reference: CAS:134-35-0
database cross reference: DrugBank:DB04789
database cross reference: KEGG:C00440
database cross reference: KNApSAcK:C00007252
has exact synonym: N-[4-({[(6S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
has_obo_namespace: chebi_ontology
has_related_synonym: 5-Methyltetrahydrofolate
has_related_synonym: N-(5-methyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
has_related_synonym: [(6S)-5-methyl-5,6,7,8-tetrahydropteroyl]glutamate
id: CHEBI:15641
in subset: 3 STAR

N-acetyl-D-glucosamine 6-phosphate
type: Class
subclass of: organophosphorus compound
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: ester
subclass of: polyatomic entity
definition: An N-acyl-D-glucosamine 6-phosphate that is the N-acetyl derivative of D-glucosamine 6-phosphate. It is a component of the aminosugar metabolism.
imported from: chebi.owl
charge: 0
formula: C8H16NO9P
inchi: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1
inchikey: BRGMHAYQAZFZDJ-RTRLPJTCSA-N
mass: 301.18774
monoisotopicmass: 301.05627
has_alternative_id: CHEBI:12456
has_alternative_id: CHEBI:12564
has_alternative_id: CHEBI:21521
has_alternative_id: CHEBI:7127
database cross reference: DrugBank:DB03951
database cross reference: HMDB:HMDB0001062
database cross reference: KEGG:C00357
database cross reference: KNApSAcK:C00019661
database cross reference: PMID:17077487
database cross reference: PMID:8125098
database cross reference: PMID:8747459
database cross reference: Reaxys:2337906
has exact synonym: 2-acetamido-2-deoxy-D-glucopyranose 6-(dihydrogen phosphate)
has exact synonym: N-Acetyl-D-glucosamine 6-phosphate
has exact synonym: N-acetyl-D-glucosamine 6-phosphate
has_obo_namespace: chebi_ontology
has_related_synonym: 2-acetamido-2-deoxy-6-O-phosphono-D-glucopyranose
id: CHEBI:15784
in subset: 3 STAR

polypeptide
type: Class
subclass of: peptide
subclass of: macromolecule
definition: A peptide containing ten or more amino acid residues.
imported from: chebi.owl
formula: C4H6N2O3R2(C2H2NOR)n
has_alternative_id: CHEBI:14860
has_alternative_id: CHEBI:8314
database cross reference: KEGG:C00403
has exact synonym: Polypeptide
has exact synonym: polypeptides
has_obo_namespace: chebi_ontology
has_related_synonym: Polypeptid
has_related_synonym: polipeptido
id: CHEBI:15841
in subset: 3 STAR

arachidonic acid
type: Class
subclass of: fatty acid
definition: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.
imported from: chebi.owl
charge: 0
formula: C20H32O2
inchi: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-15-
inchikey: YZXBAPSDXZZRGB-DOFZRALJSA-N
mass: 304.46690
monoisotopicmass: 304.24023
smiles: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
has_alternative_id: CHEBI:22608
has_alternative_id: CHEBI:2799
has_alternative_id: CHEBI:40501
database cross reference: Beilstein:1913991
database cross reference: CAS:506-32-1
database cross reference: DrugBank:DB04557
database cross reference: Gmelin:58972
database cross reference: HMDB:HMDB0001043
database cross reference: KEGG:C00219
database cross reference: KNApSAcK:C00000388
database cross reference: LIPID_MAPS_instance:LMFA01030001
database cross reference: MetaCyc:ARACHIDONIC_ACID
database cross reference: PDBeChem:ACD
database cross reference: PMID:15129302
database cross reference: PMID:18931599
database cross reference: PMID:18973997
database cross reference: PMID:25584012
database cross reference: PMID:2820055
database cross reference: Reaxys:1913991
database cross reference: Wikipedia:Arachidonic_acid
has exact synonym: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid
has exact synonym: ARACHIDONIC ACID
has exact synonym: Arachidonic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoic acid
has_related_synonym: (5Z,8Z,11Z,14Z)-Icosatetraenoic acid
has_related_synonym: AA
has_related_synonym: ARA
has_related_synonym: Arachidonate
has_related_synonym: Arachidonsaeure
has_related_synonym: all-cis-5,8,11,14-eicosatetraenoic acid
has_related_synonym: cis-5,8,11,14-Eicosatetraenoic acid
has_related_synonym: cis-Delta(5,8,11,14)-eicosatetraenoic acid
id: CHEBI:15843
in subset: 3 STAR

NAD(+)
type: Class
subclass of: ester
definition: The oxidised form of nicotinamide adenine dinucleotide found in all living cells. In metabolism, NAD(+) is involved in redox reactions, carrying electrons from one reaction to another.
imported from: chebi.owl
charge: +1
formula: C21H28N7O14P2
inchikey: BAWFJGJZGIEFAR-NNYOXOHSSA-O
mass: 664.43332
monoisotopicmass: 664.11640
has_alternative_id: CHEBI:13394
has_alternative_id: CHEBI:21901
has_alternative_id: CHEBI:7422
database cross reference: Beilstein:4120619
database cross reference: CAS:53-84-9
database cross reference: COMe:MOL000026
database cross reference: DrugBank:DB01907
database cross reference: ECMDB:ECMDB00902
database cross reference: Gmelin:544242
database cross reference: HMDB:HMDB0000902
database cross reference: KEGG:C00003
database cross reference: KEGG:D00002
database cross reference: KNApSAcK:C00007256
database cross reference: LINCS:LSM-4965
database cross reference: PDBeChem:NAJ
database cross reference: Reaxys:3584133
database cross reference: YMDB:YMDB00110
has exact synonym: adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}
has_obo_namespace: chebi_ontology
has_related_synonym: DPN
has_related_synonym: Diphosphopyridine nucleotide
has_related_synonym: NAD
has_related_synonym: NAD+
has_related_synonym: Nadide
has_related_synonym: Nicotinamide adenine dinucleotide
has_related_synonym: beta-NAD
id: CHEBI:15846
in subset: 3 STAR

taurine
type: Class
subclass of: organosulfur compound
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
subclass of: polyatomic entity
definition: An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension.
imported from: chebi.owl
charge: 0
formula: C2H7NO3S
inchi: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6)
inchikey: XOAAWQZATWQOTB-UHFFFAOYSA-N
mass: 125.148
monoisotopicmass: 125.01466
smiles: C(CS(O)(=O)=O)N
has_alternative_id: CHEBI:15195
has_alternative_id: CHEBI:26852
has_alternative_id: CHEBI:45877
has_alternative_id: CHEBI:9406
database cross reference: Beilstein:1751215
database cross reference: CAS:107-35-7
database cross reference: DrugBank:DB01956
database cross reference: Drug_Central:4486
database cross reference: Gmelin:82121
database cross reference: HMDB:HMDB0000251
database cross reference: KEGG:C00245
database cross reference: KEGG:D00047
database cross reference: KNApSAcK:C00048188
database cross reference: MetaCyc:TAURINE
database cross reference: PDBeChem:TAU
database cross reference: PMID:10098958
database cross reference: PMID:10325611
database cross reference: PMID:10349454
database cross reference: PMID:10827156
database cross reference: PMID:11162030
database cross reference: PMID:11842876
database cross reference: PMID:11918831
database cross reference: PMID:11931837
database cross reference: PMID:12297216
database cross reference: PMID:12499349
database cross reference: PMID:12834252
database cross reference: PMID:14992292
database cross reference: PMID:15503229
database cross reference: PMID:15780050
database cross reference: PMID:15911239
database cross reference: PMID:16169526
database cross reference: PMID:16444816
database cross reference: PMID:16923232
database cross reference: PMID:17053427
database cross reference: PMID:17081118
database cross reference: PMID:17875433
database cross reference: PMID:17997039
database cross reference: PMID:18060526
database cross reference: PMID:18171928
database cross reference: PMID:19074966
database cross reference: PMID:19212411
database cross reference: PMID:19309105
database cross reference: PMID:19940987
database cross reference: PMID:2122710
database cross reference: PMID:21761941
database cross reference: PMID:22770225
database cross reference: PMID:2370482
database cross reference: PMID:24027187
database cross reference: PMID:2494044
database cross reference: PMID:27291853
database cross reference: PMID:27334436
database cross reference: PMID:27345710
database cross reference: PMID:27380030
database cross reference: PMID:27412799
database cross reference: PMID:27471162
database cross reference: PMID:27535560
database cross reference: PMID:3106924
database cross reference: PMID:3393260
database cross reference: PMID:6198473
database cross reference: PMID:7588651
database cross reference: PMID:8692051
database cross reference: PMID:8818047
database cross reference: PMID:9635063
database cross reference: Reaxys:1751215
database cross reference: Wikipedia:Taurine

(R)-5-diphosphomevalonic acid
type: Class
subclass of: chalcogen molecular entity
subclass of: ester
definition: The 5-diphospho derivative of (R)-mevalonic acid.
imported from: chebi.owl
charge: 0
formula: C6H14O10P2
inchi: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
inchikey: SIGQQUBJQXSAMW-ZCFIWIBFSA-N
mass: 308.11690
monoisotopicmass: 308.00622
smiles: C[C@@](O)(CCOP(O)(=O)OP(O)(O)=O)CC(O)=O
has_alternative_id: CHEBI:10989
has_alternative_id: CHEBI:18674
has_alternative_id: CHEBI:332
database cross reference: KEGG:C01143
database cross reference: KNApSAcK:C00007615
database cross reference: PDBeChem:DP6
has exact synonym: (3R)-3-hydroxy-5-{[hydroxy(phosphonooxy)phosphoryl]oxy}-3-methylpentanoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (R)-5-Diphosphomevalonate
has_related_synonym: (R)-5-diphosphomevalonate
id: CHEBI:15899
in subset: 3 STAR

phosphatidylethanolamine
type: Class
subclass of: ester
definition: A class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxy group of ethanolamine.
imported from: chebi.owl
charge: 0
formula: C7H12NO8PR2
mass: 269.146
monoisotopicmass: 269.03005
smiles: O(P(=O)(OCCN)O)CC(OC(*)=O)COC(*)=O
has_alternative_id: CHEBI:12701
has_alternative_id: CHEBI:14803
has_alternative_id: CHEBI:26030
has_alternative_id: CHEBI:26031
has_alternative_id: CHEBI:7661
has_alternative_id: CHEBI:8129
database cross reference: DrugBank:DB04327
database cross reference: HMDB:HMDB0060501
database cross reference: KEGG:C00350
database cross reference: LIPID_MAPS_instance:LMGP02010000
database cross reference: PMID:10540156
database cross reference: PMID:11042504
database cross reference: PMID:11159918
database cross reference: PMID:11829744
database cross reference: PMID:12139474
database cross reference: PMID:15653902
database cross reference: PMID:16037249
database cross reference: PMID:16303767
database cross reference: PMID:16620109
database cross reference: PMID:18034796
database cross reference: PMID:18259190
database cross reference: PMID:18398168
database cross reference: PMID:18462396
database cross reference: PMID:18570887
database cross reference: PMID:18957134
database cross reference: PMID:19393163
database cross reference: PMID:23354482
database cross reference: PMID:23369752
database cross reference: PMID:23543734
database cross reference: PMID:3196084
database cross reference: PMID:7980848
database cross reference: Wikipedia:Phosphatidylethanolamine
has exact synonym: Phosphatidylethanolamine
has exact synonym: phosphatidyl(amino)ethanols
has exact synonym: phosphatidylethanolamines
has_obo_namespace: chebi_ontology
has_related_synonym: (3-Phosphatidyl)-ethanolamine
has_related_synonym: (3-Phosphatidyl)ethanolamine
has_related_synonym: 1,2-diacyl-sn-glycero-3-phosphoethanolamine
has_related_synonym: 1-Acyl-2-acyl-sn-glycero-3-phosphoethanolamine
has_related_synonym: Cephalin
has_related_synonym: O-(1-beta-Acyl-2-acyl-sn-glycero-3-phospho)ethanolamine
has_related_synonym: PE
has_related_synonym: PtdEtn
has_related_synonym: phosphatidylethanolamines
id: CHEBI:16038
in subset: 3 STAR

dolichol
type: Class
subclass of: isoprenoid
definition: Any one of a group of prenol derivatives made up of varying numbers of cis-linked isoprene units, terminating in an alpha-saturated isoprenoid group containing an alcohol functional group, with the three isoprene units at the distal end trans-linked.
imported from: chebi.owl
charge: 0
formula: (C5H8)nC20H36O
has_alternative_id: CHEBI:14190
has_alternative_id: CHEBI:23877
has_alternative_id: CHEBI:4686
has_alternative_id: CHEBI:57636
has_alternative_id: CHEBI:67131
database cross reference: KEGG:C00381
database cross reference: PMID:12702274
database cross reference: PMID:14739709
database cross reference: PMID:20637498
database cross reference: PMID:21570481
database cross reference: PMID:22717794
database cross reference: PMID:23059969
database cross reference: PMID:8486680
has exact synonym: Dolichol
has exact synonym: alpha-(4-hydroxy-2-methylbutyl)-omega-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]poly[(2Z)-2-methylbut-2-ene-1,4-diyl]
has exact synonym: dolichol
has_obo_namespace: chebi_ontology
has_related_synonym: 2,3-dihydropolyprenol
has_related_synonym: dolichols
id: CHEBI:16091
in subset: 3 STAR

cholesterol
type: Class
subclass of: lipid
subclass of: Restriction
  on property: isRiskFactorFor
  some values from: Alzheimer's disease
definition: A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.
imported from: chebi.owl
charge: 0
formula: C27H46O
inchi: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
inchikey: HVYWMOMLDIMFJA-DPAQBDIFSA-N
mass: 386.655
monoisotopicmass: 386.35487
relation: Alzpathway: APOE-cholesterol transport. Source: https://pubmed.ncbi.nlm.nih.gov/23620513/
has_alternative_id: CHEBI:13982
has_alternative_id: CHEBI:23204
has_alternative_id: CHEBI:3659
has_alternative_id: CHEBI:41564
database cross reference: Beilstein:2060565
database cross reference: CAS:57-88-5
database cross reference: DrugBank:DB04540
database cross reference: Gmelin:550297
database cross reference: HMDB:HMDB0000067
database cross reference: KEGG:C00187
database cross reference: KEGG:D00040
database cross reference: KNApSAcK:C00003648
database cross reference: LIPID_MAPS_instance:LMST01010001
database cross reference: MetaCyc:CHOLESTEROL
database cross reference: PDBeChem:CLR
database cross reference: PMID:10901445
database cross reference: PMID:11412894
database cross reference: PMID:16341241
database cross reference: PMID:24287311
database cross reference: PMID:25308664
database cross reference: PMID:25451949
database cross reference: PMID:25522988
database cross reference: PMID:25658343
database cross reference: PMID:25977713
database cross reference: PMID:4696527
database cross reference: PMID:8838010
database cross reference: Reaxys:2060565
database cross reference: Wikipedia:Cholesterol
has exact synonym: CHOLESTEROL
has exact synonym: Cholesterol
has exact synonym: cholest-5-en-3beta-ol
has exact synonym: cholesterol
has_obo_namespace: chebi_ontology
has_related_synonym: (3beta,14beta,17alpha)-cholest-5-en-3-ol
has_related_synonym: Cholest-5-en-3beta-ol
has_related_synonym: Cholesterin
id: CHEBI:16113
in subset: 3 STAR

sulfate
type: Class
subclass of: ion
subclass of: chalcogen molecular entity
subclass of: polyatomic entity
definition: A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid.
imported from: chebi.owl
charge: -2
formula: O4S
inchi: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
inchikey: QAOWNCQODCNURD-UHFFFAOYSA-L
mass: 96.06360
monoisotopicmass: 95.95283
smiles: [O-]S([O-])(=O)=O
has_alternative_id: CHEBI:15135
has_alternative_id: CHEBI:45687
has_alternative_id: CHEBI:9335
database cross reference: Beilstein:3648446
database cross reference: CAS:14808-79-8
database cross reference: Gmelin:2120
database cross reference: HMDB:HMDB0001448
database cross reference: KEGG:C00059
database cross reference: KEGG:D05963
database cross reference: MetaCyc:SULFATE
database cross reference: PDBeChem:SO4
database cross reference: PMID:11200094
database cross reference: PMID:11452993
database cross reference: PMID:11581495
database cross reference: PMID:11798107
database cross reference: PMID:12166931
database cross reference: PMID:12668033
database cross reference: PMID:14597181
database cross reference: PMID:15093386
database cross reference: PMID:15984785
database cross reference: PMID:16186560
database cross reference: PMID:16345535
database cross reference: PMID:16347366
database cross reference: PMID:16348007
database cross reference: PMID:16483812
database cross reference: PMID:16534979
database cross reference: PMID:16656509
database cross reference: PMID:16742508
database cross reference: PMID:16742518
database cross reference: PMID:17120760
database cross reference: PMID:17420092
database cross reference: PMID:17439666
database cross reference: PMID:17709180
database cross reference: PMID:18398178
database cross reference: PMID:18815700
database cross reference: PMID:18846414
database cross reference: PMID:19047345
database cross reference: PMID:19244483
database cross reference: PMID:19544990
database cross reference: PMID:19628332
database cross reference: PMID:19812358
database cross reference: PMID:30398859
database cross reference: Reaxys:3648446
database cross reference: Wikipedia:Sulfate
has exact synonym: Sulfate
has exact synonym: sulfate
has exact synonym: tetraoxidosulfate(2-)
has exact synonym: tetraoxosulfate(2-)
has exact synonym: tetraoxosulfate(VI)
has_obo_namespace: chebi_ontology
has_related_synonym: SO4(2-)
has_related_synonym: SULFATE ION
has_related_synonym: Sulfate anion(2-)
has_related_synonym: Sulfate dianion
has_related_synonym: Sulfate(2-)
has_related_synonym: Sulfuric acid ion(2-)
has_related_synonym: [SO4](2-)
has_related_synonym: sulphate
has_related_synonym: sulphate ion
id: CHEBI:16189
in subset: 3 STAR

hydrogen peroxide
type: Class
subclass of: chalcogen molecular entity
subclass of: polyatomic entity
definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
imported from: chebi.owl
charge: 0
formula: H2O2
inchi: InChI=1S/H2O2/c1-2/h1-2H
inchikey: MHAJPDPJQMAIIY-UHFFFAOYSA-N
mass: 34.01468
monoisotopicmass: 34.00548
smiles: [H]OO[H]
has_alternative_id: CHEBI:13354
has_alternative_id: CHEBI:13355
has_alternative_id: CHEBI:24637
has_alternative_id: CHEBI:44812
has_alternative_id: CHEBI:5586
database cross reference: Beilstein:3587191
database cross reference: CAS:7722-84-1
database cross reference: Drug_Central:3281
database cross reference: Gmelin:509
database cross reference: HMDB:HMDB0003125
database cross reference: KEGG:C00027
database cross reference: KEGG:D00008
database cross reference: MetaCyc:HYDROGEN-PEROXIDE
database cross reference: MolBase:932
database cross reference: PDBeChem:PEO
database cross reference: PMID:10455187
database cross reference: PMID:10557015
database cross reference: PMID:10849784
database cross reference: PMID:11033421
database cross reference: PMID:11105916
database cross reference: PMID:11318558
database cross reference: PMID:11387393
database cross reference: PMID:11809417
database cross reference: PMID:11864786
database cross reference: PMID:11893576
database cross reference: PMID:12867293
database cross reference: PMID:12934880
database cross reference: PMID:14679422
database cross reference: PMID:15028418
database cross reference: PMID:15133946
database cross reference: PMID:15298493
database cross reference: PMID:16337875
database cross reference: PMID:16463018
database cross reference: PMID:16864869
database cross reference: PMID:17020896
database cross reference: PMID:17179007
database cross reference: PMID:17610934
database cross reference: PMID:17948137
database cross reference: PMID:18179203
database cross reference: PMID:18182702
database cross reference: PMID:18306736
database cross reference: PMID:18443210
database cross reference: PMID:18592736
database cross reference: PMID:19107210
database cross reference: PMID:19229032
database cross reference: PMID:19297450
database cross reference: PMID:19509065
database cross reference: PMID:26352695
database cross reference: PMID:26365231
database cross reference: PMID:7548021
database cross reference: PMID:7581816
database cross reference: PMID:8048546
database cross reference: PMID:8375042
database cross reference: PMID:8451754
database cross reference: PMID:9051670
database cross reference: PMID:9100841
database cross reference: PMID:9168257
database cross reference: PMID:9202721
database cross reference: PMID:9558114
database cross reference: PPDB:387
database cross reference: Reaxys:3587191
database cross reference: Wikipedia:Hydrogen_peroxide
has exact synonym: HYDROGEN PEROXIDE
has exact synonym: Hydrogen peroxide
has exact synonym: bis(hydridooxygen)(O--O)
has exact synonym: dihydrogen peroxide
has exact synonym: dihydrogen(peroxide)
has exact synonym: dioxidane

phospholipid
type: Class
subclass of: lipid
subclass of: organic phosphate
subclass of: phosphoric ester
definition: A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides.
imported from: chebi.owl
has_alternative_id: CHEBI:14816
has_alternative_id: CHEBI:26063
has_alternative_id: CHEBI:8150
database cross reference: KEGG:C00865
has exact synonym: Phospholipid
has_obo_namespace: chebi_ontology
has_related_synonym: a phospholipid derivative
has_related_synonym: phospholipids
id: CHEBI:16247
in subset: 3 STAR

phosphatidic acid
type: Class
subclass of: ester
definition: A derivative of glycerol in which one hydroxy group, commonly but not necessarily primary, is esterified with phosphoric acid and the other two are esterified with fatty acids.
imported from: chebi.owl
charge: 0
formula: C5H7O8PR2
mass: 226.07800
monoisotopicmass: 225.98785
smiles: OP(O)(=O)OCC(COC([*])=O)OC([*])=O
has_alternative_id: CHEBI:14795
has_alternative_id: CHEBI:26023
has_alternative_id: CHEBI:8122
database cross reference: KEGG:C00416
has exact synonym: Phosphatidic acid
has_obo_namespace: chebi_ontology
has_related_synonym: 1,2-Diacyl-sn-glycerol 3-phosphate
has_related_synonym: 3-sn-Phosphatidate
has_related_synonym: Phosphatidate
has_related_synonym: phosphatidic acids
id: CHEBI:16337
in subset: 3 STAR

ubiquinones
type: Class
subclass of: chalcogen molecular entity
subclass of: carbon group molecular entity
subclass of: polyatomic entity
definition: Any benzoquinone derived from 2,3-dimethoxy-5-methylbenzoquinone; one of a group of naturally occurring homologues. The redox-active quinoid moiety usually carries a polyprenoid side chain at position 6, the number of isoprenoid units in which is species-specific. Ubiquinones are involved in the control of mitochondrial electron transport, and are also potent anti-oxidants.
imported from: chebi.owl
charge: 0
formula: C9H10O4(C5H8)n
has_alternative_id: CHEBI:15279
has_alternative_id: CHEBI:27186
has_alternative_id: CHEBI:9852
database cross reference: CAS:1339-63-5
database cross reference: KEGG:C00399
database cross reference: PMID:15788391
database cross reference: PMID:7599208
has exact synonym: Ubiquinones
has_obo_namespace: chebi_ontology
has_related_synonym: CoQ
has_related_synonym: Coenzym Q
has_related_synonym: Coenzyme Q
has_related_synonym: Koenzym Q
has_related_synonym: Q
has_related_synonym: Ubichinon
has_related_synonym: Ubiquinone
has_related_synonym: a ubiquinone
has_related_synonym: coenzyme Q
has_related_synonym: coenzymes Q
has_related_synonym: mitochondrial ubiquinone
has_related_synonym: mitochondrial ubiquinones
has_related_synonym: mitoquinones
id: CHEBI:16389
in subset: 3 STAR

sphingosine
type: Class
subclass of: lipid
definition: A sphing-4-enine in which the double bond is trans.
imported from: chebi.owl
charge: 0
formula: C18H37NO2
inchi: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1
inchikey: WWUZIQQURGPMPG-KRWOKUGFSA-N
mass: 299.49190
monoisotopicmass: 299.28243
smiles: CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO
has_alternative_id: CHEBI:15102
has_alternative_id: CHEBI:207585
has_alternative_id: CHEBI:26741
has_alternative_id: CHEBI:9224
database cross reference: Beilstein:1727294
database cross reference: Beilstein:4676153
database cross reference: CAS:123-78-4
database cross reference: DrugBank:DB03203
database cross reference: HMDB:HMDB0000252
database cross reference: KEGG:C00319
database cross reference: LIPID_MAPS_instance:LMSP01010001
database cross reference: PDBeChem:SQS
database cross reference: PMID:10453988
database cross reference: PMID:16341241
database cross reference: PMID:24731183
database cross reference: PMID:8482346
database cross reference: Reaxys:1727294
has exact synonym: (2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol
has exact synonym: Sphingosine
has_obo_namespace: chebi_ontology
has_related_synonym: (2S,3R)-(E)-2-amino-1,3-dihydroxy-4-octadecene
has_related_synonym: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-ene-1-ol
has_related_synonym: (2S,3R,4E)-2-amino-4-octadecene-1,3-diol
has_related_synonym: (2S,3R,E)-2-aminooctadec-4-ene-1,3-diol
has_related_synonym: (4E)-sphing-4-enine
has_related_synonym: (4E)-sphingenine
has_related_synonym: (E)-2-amino-4-octadecan-1,3-diol
has_related_synonym: (E)-D-erythro-4-octadecene-1,3-diol
has_related_synonym: 2-amino-4-octadecene-1,3-diol
has_related_synonym: C18 sphingosine
has_related_synonym: D-(+)-erythro-1,3-dihydroxy-2-amino-4-trans-octadecene
has_related_synonym: D-erythro-sphingosine
has_related_synonym: Sph
has_related_synonym: Sphing-4-enine
has_related_synonym: Sphingenine
has_related_synonym: Sphingoid
has_related_synonym: Sphingosine d18:1
has_related_synonym: sphingosin
has_related_synonym: trans-4-sphingenine
has_related_synonym: trans-D-erythro-2-amino-4-octadecene-1,3-diol
id: CHEBI:16393
in subset: 3 STAR

NADPH
type: Class
subclass of: ester
definition: The reduced form of NADP+; used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.
imported from: chebi.owl
charge: 0
formula: C21H30N7O17P3
inchikey: ACFIXJIJDZMPPO-NNYOXOHSSA-N
mass: 745.42116
monoisotopicmass: 745.09110
has_alternative_id: CHEBI:13399
has_alternative_id: CHEBI:13400
has_alternative_id: CHEBI:21904
has_alternative_id: CHEBI:44286
has_alternative_id: CHEBI:7425
database cross reference: Beilstein:77911
database cross reference: CAS:53-57-6
database cross reference: COMe:MOL000028
database cross reference: ECMDB:ECMDB04111
database cross reference: HMDB:HMDB0000221
database cross reference: KEGG:C00005
database cross reference: KNApSAcK:C00019545
database cross reference: PDBeChem:NDP
database cross reference: PMID:16884311
database cross reference: PMID:17371809
database cross reference: PMID:8627598
database cross reference: YMDB:YMDB00426
has exact synonym: 2'-O-phosphonoadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}
has exact synonym: NADPH
has_obo_namespace: chebi_ontology
has_related_synonym: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
has_related_synonym: Reduced nicotinamide adenine dinucleotide phosphate
has_related_synonym: TPNH
has_related_synonym: dihydronicotinamide-adenine dinucleotide phosphate
has_related_synonym: reduced nicotinamide-adenine dinucleotide phosphate
id: CHEBI:16474
in subset: 3 STAR

lipoic acid
type: Class
subclass of: fatty acid
definition: A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.
imported from: chebi.owl
charge: 0
formula: C8H14O2S2
inchi: InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)
inchikey: AGBQKNBQESQNJD-UHFFFAOYSA-N
mass: 206.32756
monoisotopicmass: 206.04352
smiles: OC(=O)CCCCC1CCSS1
has_alternative_id: CHEBI:146958
has_alternative_id: CHEBI:25058
has_alternative_id: CHEBI:6492
database cross reference: Beilstein:122410
database cross reference: Beilstein:81853
database cross reference: CAS:62-46-4
database cross reference: DrugBank:DB00166
database cross reference: Drug_Central:4732
database cross reference: ECMDB:ECMDB01451
database cross reference: Gmelin:720915
database cross reference: KEGG:C00725
database cross reference: KEGG:D00086
database cross reference: PMID:7519986
database cross reference: PMID:7548757
database cross reference: Reaxys:81853
database cross reference: Wikipedia:Lipoic_acid
database cross reference: YMDB:YMDB00334
has exact synonym: 5-(1,2-dithiolan-3-yl)pentanoic acid
has exact synonym: Lipoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: 1,2-dithiolane-3-pentanoic acid
has_related_synonym: 1,2-dithiolane-3-valeric acid
has_related_synonym: 5-(1,2-dithiolan-3-yl)valeric acid
has_related_synonym: 5-(dithiolan-3-yl)valeric acid
has_related_synonym: 5-[3-(1,2-dithiolanyl)]pentanoic acid
has_related_synonym: 6,8-thioctic acid
has_related_synonym: 6,8-thiotic acid
has_related_synonym: 6-thioctic acid
has_related_synonym: 6-thiotic acid
has_related_synonym: Acetate-replacing factor
has_related_synonym: Biletan
has_related_synonym: Thioctansaeure
has_related_synonym: Thioctic acid
has_related_synonym: Thioctsaeure
has_related_synonym: Thioktsaeure
has_related_synonym: alpha-Lipoic acid
has_related_synonym: alpha-Liponsaeure
has_related_synonym: alpha-lipoic acid
has_related_synonym: liponic acid
id: CHEBI:16494
in subset: 3 STAR

lanosterol
type: Class
subclass of: isoprenoid
definition: A tetracyclic triterpenoid that is lanosta-8,24-diene substituted by a beta-hydroxy group at the 3beta position. It is the compound from which all steroids are derived.
imported from: chebi.owl
charge: 0
formula: C30H50O
inchi: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1
inchikey: CAHGCLMLTWQZNJ-BQNIITSRSA-N
mass: 426.71740
monoisotopicmass: 426.38617
has_alternative_id: CHEBI:14500
has_alternative_id: CHEBI:25011
has_alternative_id: CHEBI:43584
has_alternative_id: CHEBI:6374
database cross reference: Beilstein:2226449
database cross reference: CAS:79-63-0
database cross reference: DrugBank:DB03696
database cross reference: HMDB:HMDB0001251
database cross reference: KEGG:C01724
database cross reference: KNApSAcK:C00003657
database cross reference: LIPID_MAPS_instance:LMST01010017
database cross reference: MetaCyc:LANOSTEROL
database cross reference: PDBeChem:LAN
database cross reference: PMID:14660793
database cross reference: PMID:16445886
database cross reference: PMID:21818119
database cross reference: PMID:21838962
database cross reference: PMID:22824432
database cross reference: PMID:22933236
database cross reference: PMID:22988818
database cross reference: PMID:24525128
database cross reference: PMID:26069216
database cross reference: PMID:26200341
database cross reference: Reaxys:2226449
database cross reference: Wikipedia:Lanosterol
has exact synonym: LANOSTEROL
has exact synonym: Lanosterol
has exact synonym: lanosta-8,24-dien-3beta-ol
has exact synonym: lanosterol
has_obo_namespace: chebi_ontology
has_related_synonym: (3beta)-lanosta-8,24-dien-3-ol
has_related_synonym: (3beta,5alpha)-4,4,14-trimethylcholesta-8,24-dien-3-ol
has_related_synonym: 4,4',14alpha-Trimethyl-5alpha-cholesta-8,24-dien-3beta-ol
has_related_synonym: Lanosterin
id: CHEBI:16521
in subset: 3 STAR

protein polypeptide chain
type: Class
subclass of: polypeptide
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
definition: A naturally occurring polypeptide synthesized at the ribosome.
imported from: chebi.owl
has_alternative_id: CHEBI:8526
database cross reference: KEGG:C00017
has_obo_namespace: chebi_ontology
has_related_synonym: Protein
has_related_synonym: polypeptide chain
has_related_synonym: protein polypeptide chains
id: CHEBI:16541
in subset: 3 STAR

isopentenyl diphosphate
type: Class
subclass of: ester
definition: A prenol phosphate comprising 3-methylbut-3-en-1-ol having an O-diphosphate substituent.
imported from: chebi.owl
charge: 0
formula: C5H12O7P2
inchi: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)
inchikey: NUHSROFQTUXZQQ-UHFFFAOYSA-N
mass: 246.09210
monoisotopicmass: 246.00583
smiles: CC(=C)CCOP(O)(=O)OP(O)(O)=O
has_alternative_id: CHEBI:14473
has_alternative_id: CHEBI:24907
has_alternative_id: CHEBI:6037
database cross reference: Beilstein:1713792
database cross reference: CAS:358-71-4
database cross reference: DrugBank:DB04714
database cross reference: KEGG:C00129
database cross reference: KNApSAcK:C00000848
database cross reference: LIPID_MAPS_instance:LMPR01010008
database cross reference: PDBeChem:IPE
database cross reference: PMID:11278429
database cross reference: PMID:15450402
database cross reference: PMID:23000003
database cross reference: PMID:23543734
database cross reference: PMID:23747531
database cross reference: PMID:23872678
database cross reference: PMID:7584140
database cross reference: PMID:7753173
database cross reference: Reaxys:1713792
database cross reference: Wikipedia:Isopentenyl_pyrophosphate
has exact synonym: 3-methylbut-3-en-1-yl trihydrogen diphosphate
has exact synonym: Isopentenyl diphosphate
has_obo_namespace: chebi_ontology
has_related_synonym: 3-Methyl-3-butenyl pyrophosphate
has_related_synonym: 3-methylbut-3-en-1-yl trihydrogen diphosphate
has_related_synonym: 3-methylbut-3-enyl phosphono hydrogen phosphate
has_related_synonym: Diphosphoric acid mono(3-methyl-3-butenyl) ester
has_related_synonym: IPP
has_related_synonym: IPPP
has_related_synonym: Isopentenyl pyrophosphate
has_related_synonym: Mono(3-methyl-3-butenyl) diphosphate
has_related_synonym: delta-3-Isopentenyl pyrophosphate
has_related_synonym: delta3-Isopentenyl diphosphate
has_related_synonym: delta3-Methyl-3-butenyl diphosphate
has_related_synonym: delta3-isopentenyl diphosphate
id: CHEBI:16584
in subset: 3 STAR

hypotaurine
type: Class
subclass of: organosulfur compound
subclass of: polyatomic entity
definition: An aminosulfinic acid comprising ethylamine having the sulfo group at the 2-position.
imported from: chebi.owl
charge: 0
formula: C2H7NO2S
inchi: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
inchikey: VVIUBCNYACGLLV-UHFFFAOYSA-N
mass: 109.14852
monoisotopicmass: 109.01975
smiles: NCCS(O)=O
has_alternative_id: CHEBI:14429
has_alternative_id: CHEBI:24760
has_alternative_id: CHEBI:5839
database cross reference: CAS:300-84-5
database cross reference: HMDB:HMDB0000965
database cross reference: KEGG:C00519
database cross reference: MetaCyc:HYPOTAURINE
database cross reference: PMID:22735334
database cross reference: Reaxys:1743127
database cross reference: Wikipedia:Hypotaurine
has exact synonym: 2-aminoethanesulfinic acid
has exact synonym: Hypotaurine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Aminoethanesulfinic acid
id: CHEBI:16668
in subset: 3 STAR

peptide
type: Class
subclass of: organonitrogen compound
definition: Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
imported from: chebi.owl
charge: 0
formula: (C2H2NOR)nC2H3NOR
has_alternative_id: CHEBI:14753
has_alternative_id: CHEBI:25906
has_alternative_id: CHEBI:7990
database cross reference: KEGG:C00012
has exact synonym: Peptide
has exact synonym: peptides
has_obo_namespace: chebi_ontology
has_related_synonym: Peptid
has_related_synonym: peptido
has_related_synonym: peptidos
id: CHEBI:16670
in subset: 3 STAR

melatonin
type: Class
subclass of: organonitrogen compound
definition: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
imported from: chebi.owl
charge: 0
formula: C13H16N2O2
inchi: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
inchikey: DRLFMBDRBRZALE-UHFFFAOYSA-N
mass: 232.283
monoisotopicmass: 232.12118
smiles: C=1C=C(C=C2C(=CNC12)CCNC(=O)C)OC
has_alternative_id: CHEBI:14577
has_alternative_id: CHEBI:25180
has_alternative_id: CHEBI:6730
database cross reference: Beilstein:205542
database cross reference: CAS:73-31-4
database cross reference: DrugBank:DB01065
database cross reference: Drug_Central:1672
database cross reference: HMDB:HMDB0001389
database cross reference: KEGG:C01598
database cross reference: KEGG:D08170
database cross reference: LINCS:LSM-4779
database cross reference: MetaCyc:N-ACETYL-5-METHOXY-TRYPTAMINE
database cross reference: PDBeChem:ML1
database cross reference: PMID:16678784
database cross reference: PMID:18212404
database cross reference: PMID:18485664
database cross reference: Reaxys:205542
database cross reference: Wikipedia:Melatonin
has exact synonym: Melatonin
has exact synonym: N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide
has exact synonym: melatonin
has_obo_namespace: chebi_ontology
has_related_synonym: 5-methoxy-N-acetyltryptamine
has_related_synonym: N-Acetyl-5-methoxytryptamine
has_related_synonym: N-[2-(5-methoxyindol-3-yl)ethyl]acetamide
has_related_synonym: melatonine
id: CHEBI:16796
in subset: 3 STAR

methionine
type: Class
subclass of: organosulfur compound
subclass of: organonitrogen compound
subclass of: polyatomic entity
definition: A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.
imported from: chebi.owl
charge: 0
formula: C5H11NO2S
inchi: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)
inchikey: FFEARJCKVFRZRR-UHFFFAOYSA-N
mass: 149.21238
monoisotopicmass: 149.05105
smiles: CSCCC(N)C(O)=O
has_alternative_id: CHEBI:14590
has_alternative_id: CHEBI:25229
has_alternative_id: CHEBI:6829
database cross reference: Beilstein:636185
database cross reference: CAS:59-51-8
database cross reference: Gmelin:3117
database cross reference: KEGG:C01733
database cross reference: KEGG:D04983
database cross reference: PMID:16702333
database cross reference: PMID:22264337
database cross reference: PMID:2543976
database cross reference: Reaxys:636185
database cross reference: UM-BBD_compID:c0094
database cross reference: Wikipedia:Methionine
has exact synonym: Methionine
has exact synonym: methionine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Amino-4-(methylthio)butyric acid
has_related_synonym: 2-amino-4-(methylsulfanyl)butanoic acid
has_related_synonym: 2-amino-4-(methylthio)butanoic acid
has_related_synonym: DL-Methionine
has_related_synonym: Hmet
has_related_synonym: M
has_related_synonym: Met
has_related_synonym: Methionin
has_related_synonym: Racemethionine
has_related_synonym: alpha-amino-gamma-methylmercaptobutyric acid
has_related_synonym: metionina
id: CHEBI:16811
in subset: 3 STAR

L-tryptophan
type: Class
subclass of: carbon group molecular entity
definition: The L-enantiomer of tryptophan.
imported from: chebi.owl
charge: 0
formula: C11H12N2O2
inchi: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1
inchikey: QIVBCDIJIAJPQS-VIFPVBQESA-N
mass: 204.22526
monoisotopicmass: 204.08988
smiles: N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
has_alternative_id: CHEBI:13178
has_alternative_id: CHEBI:184633
has_alternative_id: CHEBI:21407
has_alternative_id: CHEBI:45988
has_alternative_id: CHEBI:46086
has_alternative_id: CHEBI:46125
has_alternative_id: CHEBI:46225
has_alternative_id: CHEBI:6310
database cross reference: Beilstein:86197
database cross reference: CAS:73-22-3
database cross reference: DrugBank:DB00150
database cross reference: Drug_Central:2780
database cross reference: ECMDB:ECMDB00929
database cross reference: Gmelin:51434
database cross reference: HMDB:HMDB0000929
database cross reference: KEGG:C00078
database cross reference: KEGG:D00020
database cross reference: KNApSAcK:C00001396
database cross reference: MetaCyc:TRP
database cross reference: PDBeChem:TRP
database cross reference: PMID:11395471
database cross reference: PMID:11750787
database cross reference: PMID:11888576
database cross reference: PMID:12766158
database cross reference: PMID:12830226
database cross reference: PMID:12871129
database cross reference: PMID:15206750
database cross reference: PMID:16740930
database cross reference: PMID:16934873
database cross reference: PMID:17127472
database cross reference: PMID:17177562
database cross reference: PMID:17430113
database cross reference: PMID:17585690
database cross reference: PMID:17690425
database cross reference: PMID:17826001
database cross reference: PMID:18234569
database cross reference: PMID:18419734
database cross reference: PMID:18949702
database cross reference: PMID:19896323
database cross reference: PMID:21856896
database cross reference: PMID:22071091
database cross reference: PMID:22162421
database cross reference: PMID:22299628
database cross reference: PMID:22386992
database cross reference: PMID:22402312
database cross reference: PMID:22415302
database cross reference: PMID:22415306
database cross reference: PMID:2917974
database cross reference: Reaxys:86197
database cross reference: Wikipedia:Tryptophan
database cross reference: YMDB:YMDB00126
has exact synonym: L-Tryptophan
has exact synonym: L-tryptophan
has_obo_namespace: chebi_ontology
has_related_synonym: (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid
has_related_synonym: (S)-alpha-Amino-beta-(3-indolyl)-propionic acid
has_related_synonym: (S)-alpha-amino-1H-indole-3-propanoic acid
has_related_synonym: (S)-tryptophan
has_related_synonym: L-(-)-tryptophan
has_related_synonym: L-beta-3-indolylalanine
has_related_synonym: TRYPTOPHAN
has_related_synonym: Trp
has_related_synonym: Tryptophan
has_related_synonym: W
has_related_synonym: tryptophan
id: CHEBI:16828
in subset: 3 STAR

glutathione
type: Class
subclass of: organosulfur compound
subclass of: organonitrogen compound
definition: A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine.
imported from: chebi.owl
charge: 0
formula: C10H17N3O6S
inchi: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1
inchikey: RWSXRVCMGQZWBV-WDSKDSINSA-N
mass: 307.320
monoisotopicmass: 307.08381
has_alternative_id: CHEBI:12402
has_alternative_id: CHEBI:14327
has_alternative_id: CHEBI:24334
has_alternative_id: CHEBI:42873
has_alternative_id: CHEBI:43049
has_alternative_id: CHEBI:5437
database cross reference: CAS:70-18-8
database cross reference: DrugBank:DB00143
database cross reference: Drug_Central:1312
database cross reference: HMDB:HMDB0000125
database cross reference: KEGG:C00051
database cross reference: KEGG:D00014
database cross reference: KNApSAcK:C00001518
database cross reference: MetaCyc:GLUTATHIONE
database cross reference: PDBeChem:GSH
database cross reference: PMID:17439666
database cross reference: PMID:4200890
database cross reference: PMID:4745654
database cross reference: Reaxys:1729812
database cross reference: Wikipedia:Glutathione
has exact synonym: Glutathione
has exact synonym: L-gamma-glutamyl-L-cysteinylglycine
has_obo_namespace: chebi_ontology
has_related_synonym: 5-L-Glutamyl-L-cysteinylglycine
has_related_synonym: GSH
has_related_synonym: Glutathione-SH
has_related_synonym: N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine
has_related_synonym: Reduced glutathione
has_related_synonym: gamma-L-Glutamyl-L-cysteinyl-glycine
id: CHEBI:16856
in subset: 3 STAR

gamma-aminobutyric acid
type: Class
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
subclass of: polyatomic entity
definition: A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
imported from: chebi.owl
charge: 0
formula: C4H9NO2
inchi: InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
inchikey: BTCSSZJGUNDROE-UHFFFAOYSA-N
mass: 103.11980
monoisotopicmass: 103.06333
smiles: NCCCC(O)=O
has_alternative_id: CHEBI:1786
has_alternative_id: CHEBI:193777
has_alternative_id: CHEBI:20318
has_alternative_id: CHEBI:40483
database cross reference: BPDB:2298
database cross reference: Beilstein:906818
database cross reference: CAS:56-12-2
database cross reference: DrugBank:DB02530
database cross reference: Drug_Central:1262
database cross reference: Gmelin:49775
database cross reference: HMDB:HMDB0000112
database cross reference: KEGG:C00334
database cross reference: KEGG:D00058
database cross reference: KNApSAcK:C00001337
database cross reference: LIPID_MAPS_instance:LMFA01100039
database cross reference: MetaCyc:4-AMINO-BUTYRATE
database cross reference: PDBeChem:ABU
database cross reference: PMID:10630630
database cross reference: PMID:10930630
database cross reference: PMID:16276116
database cross reference: PMID:21614609
database cross reference: PMID:22770225
database cross reference: Reaxys:906818
database cross reference: Wikipedia:Gamma-Aminobutyric_acid
has exact synonym: 4-aminobutanoic acid
has exact synonym: gamma-Aminobutyric acid
has exact synonym: gamma-aminobutyric acid
has_obo_namespace: chebi_ontology
has_related_synonym: 4-Aminobutanoic acid
has_related_synonym: 4-Aminobutyric acid
has_related_synonym: 4-aminobutanoic acid
has_related_synonym: 4-aminobutyric acid
has_related_synonym: 4Abu
has_related_synonym: GABA
has_related_synonym: GAMMA-AMINO-BUTANOIC ACID
has_related_synonym: gamma-Aminobuttersaeure
has_related_synonym: gamma-amino-n-butyric acid
has_related_synonym: gamma-aminobutanoic acid
has_related_synonym: omega-aminobutyric acid
has_related_synonym: piperidic acid
has_related_synonym: piperidinic acid
id: CHEBI:16865
in subset: 3 STAR

NADH
type: Class
subclass of: ester
definition: A coenzyme found in all living cells; consists of two nucleotides joined through their 5'-phosphate groups, with one nucleotide containing an adenine base and the other containing nicotinamide.
imported from: chebi.owl
charge: 0
formula: C21H29N7O14P2
inchikey: BOPGDPNILDQYTO-NNYOXOHSSA-N
mass: 665.44126
monoisotopicmass: 665.12477
has_alternative_id: CHEBI:13395
has_alternative_id: CHEBI:13396
has_alternative_id: CHEBI:21902
has_alternative_id: CHEBI:44216
has_alternative_id: CHEBI:7423
database cross reference: Beilstein:79324
database cross reference: CAS:58-68-4
database cross reference: COMe:MOL000027
database cross reference: DrugBank:DB00157
database cross reference: Gmelin:544241
database cross reference: HMDB:HMDB0001487
database cross reference: KEGG:C00004
database cross reference: KNApSAcK:C00019343
database cross reference: PDBeChem:NAI
database cross reference: PMID:11259315
database cross reference: PMID:19459318
database cross reference: Reaxys:79324
database cross reference: Wikipedia:Nicotinamide_adenine_dinucleotide
has exact synonym: NADH
has exact synonym: adenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}
has_obo_namespace: chebi_ontology
has_related_synonym: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE
has_related_synonym: DPNH
has_related_synonym: Reduced nicotinamide adenine dinucleotide
has_related_synonym: nicotinamide adenine dinucleotide (reduced)
id: CHEBI:16908
in subset: 3 STAR

deoxyribonucleic acid
type: Class
subclass of: pnictogen molecular entity
subclass of: information biomacromolecule
definition: High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms.
imported from: chebi.owl
has_alternative_id: CHEBI:13302
has_alternative_id: CHEBI:21123
has_alternative_id: CHEBI:33698
has_alternative_id: CHEBI:4291
database cross reference: CAS:9007-49-2
database cross reference: KEGG:C00039
has exact synonym: Deoxyribonucleic acid
has exact synonym: deoxyribonucleic acids
has_obo_namespace: chebi_ontology
has_related_synonym: (Deoxyribonucleotide)m
has_related_synonym: (Deoxyribonucleotide)n
has_related_synonym: (Deoxyribonucleotide)n+m
has_related_synonym: DNA
has_related_synonym: DNAn
has_related_synonym: DNAn+1
has_related_synonym: DNS
has_related_synonym: Desoxyribonukleinsaeure
has_related_synonym: deoxyribonucleic acids
has_related_synonym: desoxyribose nucleic acid
has_related_synonym: thymus nucleic acid
id: CHEBI:16991
in subset: 3 STAR

ketone
type: Class
subclass of: organic molecule
definition: A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H).
imported from: chebi.owl
charge: 0
formula: COR2
mass: 28.010
monoisotopicmass: 27.99491
smiles: [*]C([*])=O
has_alternative_id: CHEBI:13427
has_alternative_id: CHEBI:13646
has_alternative_id: CHEBI:24974
has_alternative_id: CHEBI:6127
has_alternative_id: CHEBI:8742
database cross reference: KEGG:C01450
database cross reference: Wikipedia:Ketone
has exact synonym: Ketone
has exact synonym: ketones
has_obo_namespace: chebi_ontology
has_related_synonym: Keton
has_related_synonym: R-CO-R'
has_related_synonym: a ketone
has_related_synonym: cetone
has_related_synonym: ketones
id: CHEBI:17087
in subset: 3 STAR

geranyl diphosphate
type: Class
subclass of: ester
definition: The diphosphate of the polyprenol compound geraniol.
imported from: chebi.owl
charge: 0
formula: C10H20O7P2
inchi: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/b10-7+
inchikey: GVVPGTZRZFNKDS-JXMROGBWSA-N
mass: 314.20912
monoisotopicmass: 314.06843
smiles: CC(C)=CCC\C(C)=C\COP(O)(=O)OP(O)(O)=O
has_alternative_id: CHEBI:14299
has_alternative_id: CHEBI:24223
has_alternative_id: CHEBI:42877
has_alternative_id: CHEBI:5332
database cross reference: Beilstein:1915690
database cross reference: CAS:763-10-0
database cross reference: DrugBank:DB02552
database cross reference: KEGG:C00341
database cross reference: KNApSAcK:C00000846
database cross reference: LIPID_MAPS_instance:LMPR0102010001
database cross reference: PDBeChem:GPP
database cross reference: PMID:19049370
database cross reference: PMID:19856009
database cross reference: PMID:23607888
database cross reference: PMID:7753173
database cross reference: Reaxys:1915690
has exact synonym: (2E)-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate
has exact synonym: GERANYL DIPHOSPHATE
has exact synonym: Geranyl diphosphate
has_obo_namespace: chebi_ontology
has_related_synonym: geranyl pyrophosphate
id: CHEBI:17211
in subset: 3 STAR

homocysteine
type: Class
subclass of: carbon group molecular entity
subclass of: organonitrogen compound
subclass of: Restriction
  on property: isRiskFactorFor
  some values from: Alzheimer's disease
definition: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
imported from: chebi.owl
charge: 0
formula: C4H9NO2S
inchi: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)
inchikey: FFFHZYDWPBMWHY-UHFFFAOYSA-N
mass: 135.18580
monoisotopicmass: 135.03540
smiles: NC(CCS)C(O)=O
has_alternative_id: CHEBI:14408
has_alternative_id: CHEBI:5751
database cross reference: HMDB:HMDB0000742
database cross reference: KEGG:C05330
database cross reference: PMID:11133260
database cross reference: PMID:16596805
database cross reference: PMID:18370634
database cross reference: Wikipedia:Homocysteine
has exact synonym: 2-amino-4-sulfanylbutanoic acid
has exact synonym: Homocysteine
has exact synonym: homocysteine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Amino-4-mercaptobutyric acid
has_related_synonym: Hcy
id: CHEBI:17230
in subset: 3 STAR

glucose
type: Class
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: carbon group molecular entity
subclass of: polyatomic entity
definition: An aldohexose used as a source of energy and metabolic intermediate.
imported from: chebi.owl
charge: 0
formula: C6H12O6
mass: 180.15588
monoisotopicmass: 180.06339
has_alternative_id: CHEBI:14313
has_alternative_id: CHEBI:24277
has_alternative_id: CHEBI:33929
has_alternative_id: CHEBI:5418
database cross reference: CAS:50-99-7
database cross reference: KEGG:C00293
database cross reference: Wikipedia:Glucose
has exact synonym: Glucose
has exact synonym: gluco-hexose
has exact synonym: glucose
has_obo_namespace: chebi_ontology
has_related_synonym: DL-glucose
has_related_synonym: Glc
has_related_synonym: Glukose
id: CHEBI:17234
in subset: 3 STAR

testosterone
type: Class
subclass of: lipid
definition: An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..
imported from: chebi.owl
charge: 0
formula: C19H28O2
inchi: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
inchikey: MUMGGOZAMZWBJJ-DYKIIFRCSA-N
mass: 288.42440
monoisotopicmass: 288.20893
has_alternative_id: CHEBI:15214
has_alternative_id: CHEBI:26883
has_alternative_id: CHEBI:45798
has_alternative_id: CHEBI:9461
database cross reference: Beilstein:1915399
database cross reference: Beilstein:3653705
database cross reference: CAS:58-22-0
database cross reference: DrugBank:DB00624
database cross reference: Drug_Central:2607
database cross reference: Gmelin:538843
database cross reference: HMDB:HMDB0000234
database cross reference: KEGG:C00535
database cross reference: KEGG:D00075
database cross reference: KNApSAcK:C00003675
database cross reference: LIPID_MAPS_instance:LMST02020002
database cross reference: PDBeChem:TES
database cross reference: PMID:10438974
database cross reference: PMID:11786693
database cross reference: PMID:18900503
database cross reference: PMID:24498482
database cross reference: Reaxys:1915399
database cross reference: Wikipedia:Testosterone
has exact synonym: 17beta-hydroxyandrost-4-en-3-one
has exact synonym: TESTOSTERONE
has exact synonym: Testosterone
has exact synonym: testosterone
has_obo_namespace: chebi_ontology
has_related_synonym: 17beta-Hydroxy-4-androsten-3-one
has_related_synonym: 17beta-hydroxy-4-androsten-3-one
has_related_synonym: 4-androsten-17beta-ol-3-one
has_related_synonym: Androderm
has_related_synonym: Testosteron
has_related_synonym: testosterona
has_related_synonym: testosterone
has_related_synonym: testosteronum
id: CHEBI:17347
in subset: 3 STAR

sulfite
type: Class
subclass of: ion
subclass of: chalcogen molecular entity
subclass of: polyatomic entity
definition: A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3).
imported from: chebi.owl
charge: -2
formula: O3S
inchi: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2
inchikey: LSNNMFCWUKXFEE-UHFFFAOYSA-L
mass: 80.06420
monoisotopicmass: 79.95791
smiles: [O-]S([O-])=O
has_alternative_id: CHEBI:15139
has_alternative_id: CHEBI:45548
database cross reference: CAS:14265-45-3
database cross reference: Gmelin:1449
database cross reference: PDBeChem:SO3
has exact synonym: sulfite
has exact synonym: trioxidosulfate(2-)
has exact synonym: trioxosulfate(2-)
has exact synonym: trioxosulfate(IV)
has_obo_namespace: chebi_ontology
has_related_synonym: SO3
has_related_synonym: SO3(2-)
has_related_synonym: SULFITE ION
has_related_synonym: [SO3](2-)
has_related_synonym: sulphite
id: CHEBI:17359
in subset: 3 STAR

aldehyde
type: Class
subclass of: chalcogen molecular entity
subclass of: polyatomic entity
definition: A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
imported from: chebi.owl
charge: 0
formula: CHOR
mass: 29.01800
monoisotopicmass: 29.00274
smiles: [H]C([*])=O
has_alternative_id: CHEBI:13432
has_alternative_id: CHEBI:13753
has_alternative_id: CHEBI:13805
has_alternative_id: CHEBI:13806
has_alternative_id: CHEBI:22291
has_alternative_id: CHEBI:2554
has_alternative_id: CHEBI:8750
database cross reference: KEGG:C00071
has exact synonym: Aldehyde
has exact synonym: aldehyde
has exact synonym: aldehydes
has_obo_namespace: chebi_ontology
has_related_synonym: Aldehyd
has_related_synonym: RC(=O)H
has_related_synonym: RCHO
has_related_synonym: aldehido
has_related_synonym: aldehidos
has_related_synonym: aldehydes
has_related_synonym: aldehydum
has_related_synonym: an aldehyde
id: CHEBI:17478
in subset: 3 STAR

vitamin B9
type: Class
subclass of: organonitrogen compound
definition: Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin.
imported from: chebi.owl
has exact synonym: vitamin B9
has_obo_namespace: chebi_ontology
has_related_synonym: folate vitamer
has_related_synonym: folate vitamers
has_related_synonym: vitamin B-9
has_related_synonym: vitamin B9 vitamer
has_related_synonym: vitamin B9 vitamers
has_related_synonym: vitamins B9
id: CHEBI:176842
in subset: 3 STAR

vitamin B12
type: Class
subclass of: organonitrogen compound
definition: Any member of a group of cobalamin vitamers that exhibit biological activity against vitamin B12 deficiency. Vitamin B12 deficiency is associated with low red blood cell count and anemia. The vitamers are found in foods such as cereals, meat, fish, and poultry. The vitamers include adenosylcobalamin, hydroxocobalamin, cyanocobalamin, aquacobalamin, nitritocobalamin and methylcobabalamin (also includes their ionized, salt and phosphate derivatives).
imported from: chebi.owl
has exact synonym: vitamin B12
has_obo_namespace: chebi_ontology
has_related_synonym: vitamin B-12
has_related_synonym: vitamin B12 vitamer
has_related_synonym: vitamin B12 vitamers
has_related_synonym: vitamins B12
id: CHEBI:176843
in subset: 3 STAR

ceramide
type: Class
subclass of: lipid
definition: Ceramides (N-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide-linked fatty acid. The fatty acids are typically saturated or monounsaturated with chain lengths from 14 to 26 carbon atoms; the presence of a hydroxyl group on carbon 2 is fairly common. Ceramides are generally precursors of more complex sphingolipids. In the illustrated generalised structure, R(1) = OH, OX (where X = acyl, glycosyl, phosphate, phosphonate, etc.), or H.
imported from: chebi.owl
charge: 0
formula: C4H6NO2R3
mass: 100.09590
monoisotopicmass: 100.03985
smiles: O[C@H]([*])[C@H](C[*])NC([*])=O
has_alternative_id: CHEBI:12487
has_alternative_id: CHEBI:13954
has_alternative_id: CHEBI:23074
has_alternative_id: CHEBI:7242
database cross reference: KEGG:C00195
database cross reference: LIPID_MAPS_class:LMSP02
database cross reference: PMID:7542630
database cross reference: Wikipedia:Ceramide
has exact synonym: Ceramide
has_obo_namespace: chebi_ontology
has_related_synonym: Cer
has_related_synonym: N-acylated sphingoid
has_related_synonym: a ceramide
has_related_synonym: ceramides
id: CHEBI:17761
in subset: 3 STAR

organohalogen compound
type: Class
subclass of: halogen molecular entity
subclass of: heteroorganic entity
subclass of: carbon group molecular entity
subclass of: halide
definition: A compound containing at least one carbon-halogen bond (where X is a halogen atom).
imported from: chebi.owl
charge: 0
formula: RX
smiles: **
has_alternative_id: CHEBI:13444
has_alternative_id: CHEBI:36684
has_alternative_id: CHEBI:8767
database cross reference: KEGG:C01322
database cross reference: MetaCyc:Organohalogen-Compounds
has_obo_namespace: chebi_ontology
has_related_synonym: RX
has_related_synonym: organic halide
has_related_synonym: organic halides
has_related_synonym: organohalogen compounds
id: CHEBI:17792
in subset: 3 STAR

glutathione disulfide
type: Class
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
imported from: chebi.owl
charge: 0
formula: C20H32N6O12S2
inchikey: YPZRWBKMTBYPTK-BJDJZHNGSA-N
mass: 612.63332
monoisotopicmass: 612.15196
has_alternative_id: CHEBI:14328
has_alternative_id: CHEBI:14720
has_alternative_id: CHEBI:24336
has_alternative_id: CHEBI:42832
has_alternative_id: CHEBI:7840
database cross reference: CAS:27025-41-8
database cross reference: DrugBank:DB03310
database cross reference: Drug_Central:5130
database cross reference: KEGG:C00127
database cross reference: KEGG:D00031
database cross reference: PDBeChem:GDS
has exact synonym: (2S,2'S)-5,5'-[disulfanediylbis({(2R)-3-[(carboxymethyl)amino]-3-oxopropane-1,2-diyl}imino)]bis(2-amino-5-oxopentanoic acid)
has exact synonym: Glutathione disulfide
has_obo_namespace: chebi_ontology
has_related_synonym: GSSG
has_related_synonym: OXIDIZED GLUTATHIONE DISULFIDE
has_related_synonym: Oxidized glutathione
has_related_synonym: Oxiglutatione
has_related_synonym: glutathione disulphide
has_related_synonym: oxidised glutathione
id: CHEBI:17858
in subset: 3 STAR

ubiquinol
type: Class
subclass of: organic hydroxy compound
imported from: chebi.owl
charge: 0
formula: C9H12O4(C5H8)n
has_alternative_id: CHEBI:15278
has_alternative_id: CHEBI:27182
has_alternative_id: CHEBI:9851
database cross reference: CAS:56275-39-9
database cross reference: KEGG:C00390
has exact synonym: Ubiquinol
has_obo_namespace: chebi_ontology
has_related_synonym: CoQH2
has_related_synonym: QH(2)
has_related_synonym: QH2
has_related_synonym: a ubiquinol
has_related_synonym: coenzymes QH2
has_related_synonym: reduced ubiquinone
has_related_synonym: ubiquinols
id: CHEBI:17976
in subset: 3 STAR

acyl-CoA
type: Class
subclass of: secondary carboxamide
subclass of: adenosine 3',5'-bisphosphate
subclass of: thioester
definition: A thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid.
imported from: chebi.owl
charge: 0
formula: C22H35N7O17P3SR
mass: 794.53600
monoisotopicmass: 794.10230
has_alternative_id: CHEBI:13727
has_alternative_id: CHEBI:13802
has_alternative_id: CHEBI:22223
has_alternative_id: CHEBI:2455
database cross reference: CAS:9029-97-4
database cross reference: KEGG:C00040
database cross reference: PMID:11264983
database cross reference: PMID:11524729
database cross reference: PMID:16495773
database cross reference: PMID:21514367
database cross reference: PMID:21541677
has exact synonym: Acyl-CoA
has_obo_namespace: chebi_ontology
has_related_synonym: Acyl coenzyme A
id: CHEBI:17984
in subset: 3 STAR

chloride
type: Class
subclass of: ion
definition: A halide anion formed when chlorine picks up an electron to form an an anion.
imported from: chebi.owl
charge: -1
formula: Cl
inchi: InChI=1S/ClH/h1H/p-1
inchikey: VEXZGXHMUGYJMC-UHFFFAOYSA-M
mass: 35.45270
monoisotopicmass: 34.96940
smiles: [Cl-]
has_alternative_id: CHEBI:13291
has_alternative_id: CHEBI:13970
has_alternative_id: CHEBI:3616
has_alternative_id: CHEBI:3731
has_alternative_id: CHEBI:48804
database cross reference: Beilstein:3587171
database cross reference: CAS:16887-00-6
database cross reference: Gmelin:14910
database cross reference: KEGG:C00115
database cross reference: KEGG:C00698
database cross reference: PDBeChem:CL
database cross reference: UM-BBD_compID:c0884
has exact synonym: Chloride
has exact synonym: chloride
has exact synonym: chloride(1-)
has_obo_namespace: chebi_ontology
has_related_synonym: CHLORIDE ION
has_related_synonym: Chloride ion
has_related_synonym: Chloride(1-)
has_related_synonym: Chlorine anion
has_related_synonym: Cl(-)
has_related_synonym: Cl-
id: CHEBI:17996
in subset: 3 STAR

NADP(+)
type: Class
subclass of: ester
imported from: chebi.owl
charge: +1
formula: C21H29N7O17P3
inchikey: XJLXINKUBYWONI-NNYOXOHSSA-O
mass: 744.41322
monoisotopicmass: 744.08273
has_alternative_id: CHEBI:13398
has_alternative_id: CHEBI:21903
has_alternative_id: CHEBI:7424
database cross reference: Beilstein:3645734
database cross reference: CAS:53-59-8
database cross reference: COMe:MOL000029
database cross reference: KEGG:C00006
database cross reference: PDBeChem:NAP
has exact synonym: 2'-O-phosphonoadenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] dihydrogen diphosphate}
has_obo_namespace: chebi_ontology
has_related_synonym: NADP
has_related_synonym: NADP+
has_related_synonym: Nicotinamide adenine dinucleotide phosphate
has_related_synonym: TPN
has_related_synonym: Triphosphopyridine nucleotide
has_related_synonym: beta-Nicotinamide adenine dinucleotide phosphate
has_related_synonym: beta-nicotinamide adenine dinucleotide phosphate
has_related_synonym: oxidized nicotinamide-adenine dinucleotide phosphate
id: CHEBI:18009
in subset: 3 STAR

thiocyanate
type: Class
subclass of: ion
subclass of: chalcogen molecular entity
subclass of: polyatomic entity
definition: A pseudohalide anion obtained by deprotonation of the thiol group of thiocyanic acid.
imported from: chebi.owl
charge: -1
formula: CNS
inchi: InChI=1S/CHNS/c2-1-3/h3H/p-1
inchikey: ZMZDMBWJUHKJPS-UHFFFAOYSA-M
mass: 58.08344
monoisotopicmass: 57.97569
smiles: [S-]C#N
has_alternative_id: CHEBI:15234
has_alternative_id: CHEBI:24926
has_alternative_id: CHEBI:26954
has_alternative_id: CHEBI:45576
database cross reference: Beilstein:1901207
database cross reference: CAS:302-04-5
database cross reference: Gmelin:1089
database cross reference: PDBeChem:SCN
database cross reference: UM-BBD_compID:c0560
has exact synonym: nitridosulfidocarbonate(1-)
has exact synonym: nitridothiocarbonate(1-)
has exact synonym: nitridothiocarbonate(IV)
has exact synonym: thiocyanate
has_obo_namespace: chebi_ontology
has_related_synonym: N#C-S(-)
has_related_synonym: NCS-
has_related_synonym: Rhodanid
has_related_synonym: SCN(-)
has_related_synonym: THIOCYANATE ION
has_related_synonym: Thiozyanat
has_related_synonym: [S-C#N](-)
has_related_synonym: rhodanide
has_related_synonym: thiocyanate ion (1-)
id: CHEBI:18022
in subset: 3 STAR

lipid
type: Class
subclass of: carbon group molecular entity
subclass of: organic molecular entity
definition: 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.
imported from: chebi.owl
has_alternative_id: CHEBI:14517
has_alternative_id: CHEBI:25054
has_alternative_id: CHEBI:6486
database cross reference: KEGG:C01356
has exact synonym: Lipid
has exact synonym: lipids
has_obo_namespace: chebi_ontology
id: CHEBI:18059
in subset: 3 STAR

citrulline
type: Class
subclass of: carbon group molecular entity
subclass of: organonitrogen compound
definition: The parent compound of the citrulline class consisting of ornithine having a carbamoyl group at the N(5)-position.
imported from: chebi.owl
charge: 0
formula: C6H13N3O3
inchi: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)
inchikey: RHGKLRLOHDJJDR-UHFFFAOYSA-N
mass: 175.18584
monoisotopicmass: 175.09569
smiles: NC(CCCNC(N)=O)C(O)=O
has_alternative_id: CHEBI:14002
has_alternative_id: CHEBI:3730
database cross reference: Beilstein:1725417
database cross reference: Beilstein:2328251
database cross reference: CAS:627-77-0
database cross reference: PMID:11094453
database cross reference: PMID:11113071
database cross reference: PMID:11696417
database cross reference: PMID:1378088
database cross reference: PMID:16082501
database cross reference: PMID:16708633
database cross reference: PMID:17005970
database cross reference: PMID:17513438
database cross reference: PMID:17558653
database cross reference: PMID:17693747
database cross reference: PMID:18437289
database cross reference: PMID:18440672
database cross reference: PMID:18989563
database cross reference: PMID:19144577
database cross reference: PMID:21129371
database cross reference: PMID:21482070
database cross reference: Reaxys:1725417
database cross reference: Wikipedia:Citrulline
has exact synonym: 2-amino-5-(carbamoylamino)pentanoic acid
has exact synonym: Citrulline
has exact synonym: N(5)-carbamoylornithine
has exact synonym: citrulline
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Amino-5-uredovaleric acid
has_related_synonym: Cit
has_related_synonym: Citrullin
has_related_synonym: DL-2-amino-5-ureidovaleric acid
has_related_synonym: N(5)-(aminocarbonyl)-DL-ornithine
has_related_synonym: N(5)-(aminocarbonyl)ornithine
has_related_synonym: N(5)-carbamoyl-DL-ornithine
has_related_synonym: citrulina
has_related_synonym: dl-citrulline
id: CHEBI:18211
in subset: 3 STAR

dopamine
type: Class
subclass of: pnictogen molecular entity
subclass of: organic hydroxy compound
subclass of: organonitrogen compound
subclass of: polyatomic entity
definition: Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.
imported from: chebi.owl
charge: 0
formula: C8H11NO2
inchi: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
inchikey: VYFYYTLLBUKUHU-UHFFFAOYSA-N
mass: 153.17840
monoisotopicmass: 153.07898
smiles: NCCc1ccc(O)c(O)c1
has_alternative_id: CHEBI:11695
has_alternative_id: CHEBI:11930
has_alternative_id: CHEBI:14203
has_alternative_id: CHEBI:1764
has_alternative_id: CHEBI:23886
has_alternative_id: CHEBI:43686
database cross reference: CAS:51-61-6
database cross reference: DrugBank:DB00988
database cross reference: Drug_Central:947
database cross reference: HMDB:HMDB0000073
database cross reference: KEGG:C03758
database cross reference: KEGG:D07870
database cross reference: KNApSAcK:C00001408
database cross reference: LINCS:LSM-4630
database cross reference: MetaCyc:DOPAMINE
database cross reference: PMID:10629745
database cross reference: PMID:11149432
database cross reference: PMID:9422813
database cross reference: Reaxys:1072822
database cross reference: Wikipedia:Dopamine
has exact synonym: 4-(2-aminoethyl)benzene-1,2-diol
has exact synonym: Dopamine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-(3,4-Dihydroxyphenyl)ethylamine
has_related_synonym: 2-(3,4-dihydroxyphenyl)ethylamine
has_related_synonym: 3,4-Dihydroxyphenethylamine
has_related_synonym: 3-Hydroxytyramine
has_related_synonym: 4-(2-Aminoethyl)-1,2-benzenediol
has_related_synonym: 4-(2-Aminoethyl)benzene-1,2-diol
has_related_synonym: 4-(2-aminoethyl)-1,2-benzenediol
has_related_synonym: 4-(2-aminoethyl)catechol
has_related_synonym: 4-(2-aminoethyl)pyrocatechol
has_related_synonym: Deoxyepinephrine
has_related_synonym: Hydroxytyramin
has_related_synonym: dopamina
has_related_synonym: dopamine
has_related_synonym: dopaminum
id: CHEBI:18243
in subset: 3 STAR

iron atom
type: Class
subclass of: atom
definition: An iron group element atom that has atomic number 26.
imported from: chebi.owl
charge: 0
formula: Fe
inchi: InChI=1S/Fe
inchikey: XEEYBQQBJWHFJM-UHFFFAOYSA-N
mass: 55.84500
monoisotopicmass: 55.93494
smiles: [Fe]
has_alternative_id: CHEBI:13322
has_alternative_id: CHEBI:24872
has_alternative_id: CHEBI:5974
database cross reference: CAS:7439-89-6
database cross reference: DrugBank:DB01592
database cross reference: HMDB:HMDB0015531
database cross reference: KEGG:C00023
database cross reference: Reaxys:4122945
database cross reference: WebElements:Fe
has exact synonym: iron
has_obo_namespace: chebi_ontology
has_related_synonym: 26Fe
has_related_synonym: Eisen
has_related_synonym: Fe
has_related_synonym: Iron
has_related_synonym: fer
has_related_synonym: ferrum
has_related_synonym: hierro
has_related_synonym: iron
id: CHEBI:18248
in subset: 3 STAR

nitrile
type: Class
subclass of: organonitrogen compound
definition: A compound having the structure RC#N; thus a C-substituted derivative of hydrocyanic acid, HC#N. In systematic nomenclature, the suffix nitrile denotes the triply bound #N atom, not the carbon atom attached to it.
imported from: chebi.owl
charge: 0
formula: CNR
mass: 26.01740
monoisotopicmass: 26.00307
smiles: [*]C#N
has_alternative_id: CHEBI:13212
has_alternative_id: CHEBI:13426
has_alternative_id: CHEBI:13660
has_alternative_id: CHEBI:25547
has_alternative_id: CHEBI:7584
database cross reference: KEGG:C00726
has exact synonym: Nitrile
has exact synonym: nitrile
has exact synonym: nitriles
has_obo_namespace: chebi_ontology
has_related_synonym: Nitril
has_related_synonym: R-CN
has_related_synonym: a nitrile
has_related_synonym: nitrilos
id: CHEBI:18379
in subset: 3 STAR

magnesium(2+)
type: Class
subclass of: ion
imported from: chebi.owl
charge: +2
formula: Mg
inchi: InChI=1S/Mg/q+2
inchikey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
mass: 24.30500
monoisotopicmass: 23.98394
smiles: [Mg++]
has_alternative_id: CHEBI:13379
has_alternative_id: CHEBI:25112
has_alternative_id: CHEBI:49736
has_alternative_id: CHEBI:6635
database cross reference: CAS:22537-22-0
database cross reference: Gmelin:6857
database cross reference: KEGG:C00305
database cross reference: PDBeChem:MG
has exact synonym: magnesium cation
has exact synonym: magnesium(2+)
has exact synonym: magnesium(2+) ion
has exact synonym: magnesium(II) cation
has_obo_namespace: chebi_ontology
has_related_synonym: MAGNESIUM ION
has_related_synonym: Mg(2+)
has_related_synonym: Mg2+
has_related_synonym: magnesium, doubly charged positive ion
has_related_synonym: magnesium, ion (Mg(2+))
id: CHEBI:18420
in subset: 3 STAR

superoxide
type: Class
subclass of: ion
subclass of: chalcogen molecular entity
imported from: chebi.owl
charge: -1
formula: O2
inchi: InChI=1S/HO2/c1-2/h1H/p-1
inchikey: OUUQCZGPVNCOIJ-UHFFFAOYSA-M
mass: 31.99880
monoisotopicmass: 31.98983
smiles: [O][O-]
has_alternative_id: CHEBI:15143
has_alternative_id: CHEBI:26839
has_alternative_id: CHEBI:7710
database cross reference: CAS:11062-77-4
database cross reference: Gmelin:487
database cross reference: KEGG:C00704
has exact synonym: dioxidanidyl
has exact synonym: dioxide(.1-)
has exact synonym: superoxide
has_obo_namespace: chebi_ontology
has_related_synonym: (O2)(.-)
has_related_synonym: Hyperoxid
has_related_synonym: O2(-)
has_related_synonym: O2(.-)
has_related_synonym: O2-
has_related_synonym: O2.-
has_related_synonym: Superoxide anion
has_related_synonym: dioxide(1-)
has_related_synonym: hyperoxide
has_related_synonym: superoxide anion radical
has_related_synonym: superoxide radical
has_related_synonym: superoxide radical anion
has_related_synonym: superoxyde
id: CHEBI:18421
in subset: 3 STAR

3-hydroxy fatty acyl-CoA
type: Class
subclass of: hydroxy fatty acyl-CoA
definition: A hydroxy fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any 3-hydroxy fatty acid.
imported from: chebi.owl
charge: 0
formula: C24H39N7O18P3SR
mass: 838.58900
monoisotopicmass: 838.12851
database cross reference: PMID:12106015
database cross reference: PMID:1778900
database cross reference: PMID:20583174
database cross reference: PMID:20670938
database cross reference: PMID:20923481
database cross reference: PMID:21502722
database cross reference: PMID:7552767
has_obo_namespace: chebi_ontology
has_related_synonym: 3-hydroxy fatty acyl CoA
has_related_synonym: 3-hydroxy fatty acyl CoAs
has_related_synonym: 3-hydroxy fatty acyl coenzyme A
has_related_synonym: 3-hydroxy fatty acyl coenzyme As
has_related_synonym: 3-hydroxyacyl-CoAs
has_related_synonym: beta-hydroxy fatty acyl-CoA
has_related_synonym: beta-hydroxy fatty acyl-CoAs
has_related_synonym: beta-hydroxy fatty acyl-coenzyme A
has_related_synonym: beta-hydroxy fatty acyl-coenzyme As
has_related_synonym: beta-hydroxyacyl-CoA
has_related_synonym: beta-hydroxyacyl-CoAs
has_related_synonym: beta-hydroxyacyl-coenzyme A
has_related_synonym: beta-hydroxyacyl-coenzyme As
id: CHEBI:20060
in subset: 3 STAR

N-acetyl-D-glucosamine 1-phosphate
type: Class
subclass of: organophosphorus compound
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: ester
definition: A N-acyl-D-glucosamine 1-phosphate in which the acyl group specified is acetyl.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:21519
in subset: 3 STAR

acetylcysteine
type: Class
subclass of: organonitrogen compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:22198
in subset: 3 STAR

adenosine bisphosphate
type: Class
subclass of: adenosine phosphate
subclass of: purine nucleoside bisphosphate
subclass of: ribonucleoside bisphosphate
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: adenosine bisphosphates
id: CHEBI:22251
in subset: 3 STAR

adenosine phosphate
type: Class
subclass of: nucleoside phosphate
subclass of: adenyl ribonucleotide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: adenosine phosphates
id: CHEBI:22256
in subset: 3 STAR

antioxidant
type: Class
subclass of: chemical role
definition: A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antioxidants
has_related_synonym: antioxydant
has_related_synonym: antoxidant
id: CHEBI:22586
in subset: 3 STAR

benzoic acids
type: Class
subclass of: organic molecule
definition: Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:22723
in subset: 3 STAR

biopterins
type: Class
subclass of: pterins
imported from: chebi.owl
database cross reference: MetaCyc:All-Biopterines
has_obo_namespace: chebi_ontology
id: CHEBI:22881
in subset: 3 STAR

biphenyls
type: Class
subclass of: benzenoid aromatic compound
subclass of: ring assembly
subclass of: biaryl
definition: Benzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:22888
in subset: 3 STAR

calcium atom
type: Class
subclass of: atom
imported from: chebi.owl
charge: 0
formula: Ca
inchi: InChI=1S/Ca
inchikey: OYPRJOBELJOOCE-UHFFFAOYSA-N
mass: 40.07800
monoisotopicmass: 39.96259
smiles: [Ca]
database cross reference: CAS:7440-70-2
database cross reference: DrugBank:DB01373
database cross reference: KEGG:C00076
database cross reference: WebElements:Ca
has exact synonym: calcium
has_obo_namespace: chebi_ontology
has_related_synonym: 20Ca
has_related_synonym: Ca
has_related_synonym: Calcium
has_related_synonym: Kalzium
has_related_synonym: calcio
has_related_synonym: calcium
id: CHEBI:22984
in subset: 3 STAR

carbonyl group
type: Class
subclass of: group
imported from: chebi.owl
charge: 0
formula: CO
mass: 28.01010
monoisotopicmass: 27.99491
smiles: O=C(*)*
has exact synonym: carbonyl
has exact synonym: carbonyl group
has_obo_namespace: chebi_ontology
has_related_synonym: >C=O
id: CHEBI:23019
in subset: 3 STAR

catechin
type: Class
subclass of: carbon group molecular entity
definition: Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.
imported from: chebi.owl
charge: 0
formula: C15H14O6
inchi: InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2
inchikey: PFTAWBLQPZVEMU-UHFFFAOYSA-N
mass: 290.269
monoisotopicmass: 290.07904
database cross reference: KEGG:C17590
database cross reference: LINCS:LSM-1682
has exact synonym: catechin
has_obo_namespace: chebi_ontology
has_related_synonym: (+/-)-Catechin
has_related_synonym: catechins
id: CHEBI:23053
in subset: 3 STAR

molecular entity
type: Class
subclass of: chemical entity
definition: Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
imported from: chebi.owl
has exact synonym: molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: entidad molecular
has_related_synonym: entidades moleculares
has_related_synonym: entite moleculaire
has_related_synonym: molecular entities
has_related_synonym: molekulare Entitaet
id: CHEBI:23367
in subset: 3 STAR

diol
type: Class
subclass of: polyol
definition: A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols.
imported from: chebi.owl
database cross reference: Wikipedia:Diol
has exact synonym: diols
has_obo_namespace: chebi_ontology
id: CHEBI:23824
in subset: 3 STAR

drug
type: Class
subclass of: pharmaceutical
definition: Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: drugs
has_related_synonym: medicine
id: CHEBI:23888
in subset: 3 STAR

enzyme inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
definition: A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
imported from: chebi.owl
has exact synonym: enzyme inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: enzyme inhibitors
has_related_synonym: inhibidor enzimatico
has_related_synonym: inhibidores enzimaticos
has_related_synonym: inhibiteur enzymatique
has_related_synonym: inhibiteurs enzymatiques
id: CHEBI:23924
in subset: 3 STAR

ethanolamines
type: Class
subclass of: organonitrogen compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ethanolamine
id: CHEBI:23981
in subset: 3 STAR

acetophenazine
type: Class
subclass of: phenothiazines
definition: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the nitogen atom and an acetyl group at position 2.
imported from: chebi.owl
charge: 0
formula: C23H29N3O2S
inchi: InChI=1S/C23H29N3O2S/c1-18(28)19-7-8-23-21(17-19)26(20-5-2-3-6-22(20)29-23)10-4-9-24-11-13-25(14-12-24)15-16-27/h2-3,5-8,17,27H,4,9-16H2,1H3
inchikey: WNTYBHLDCKXEOT-UHFFFAOYSA-N
mass: 411.56138
monoisotopicmass: 411.19805
database cross reference: Beilstein:57631
database cross reference: CAS:2751-68-0
database cross reference: DrugBank:DB01063
database cross reference: Drug_Central:59
database cross reference: HMDB:HMDB0015196
database cross reference: KEGG:C06807
database cross reference: PMID:13904111
database cross reference: PMID:13986480
database cross reference: PMID:14020672
database cross reference: PMID:14211419
database cross reference: Reaxys:57631
database cross reference: Wikipedia:Acetophenazine
has exact synonym: 1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)ethanone
has exact synonym: Acetophenazine
has_obo_namespace: chebi_ontology
id: CHEBI:2401
in subset: 3 STAR

fluorine molecular entity
type: Class
subclass of: halogen molecular entity
imported from: chebi.owl
has exact synonym: fluorine molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: fluorine compounds
has_related_synonym: fluorine molecular entities
id: CHEBI:24062
in subset: 3 STAR

furans
type: Class
subclass of: organic heteromonocyclic compound
subclass of: oxacycle
definition: Compounds containing at least one furan ring.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: oxacyclopenta-2,4-dienes
id: CHEBI:24129
in subset: 3 STAR

glucocorticoid
type: Class
subclass of: lipid
definition: Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: glucocorticoids
id: CHEBI:24261
in subset: 3 STAR

chemical entity
type: Class
subclass of: object
definition: A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
imported from: chebi.owl
has exact synonym: chemical entity
has_obo_namespace: chebi_ontology
id: CHEBI:24431
in subset: 3 STAR

biological role
type: Class
subclass of: role
definition: A role played by the molecular entity or part thereof within a biological context.
imported from: chebi.owl
imported from: chiro.owl
has_obo_namespace: chebi_ontology
has_related_synonym: biological function
id: CHEBI:24432
in subset: 3 STAR

group
type: Class
subclass of: chemical entity
definition: A defined linked collection of atoms or a single atom within a molecular entity.
imported from: chebi.owl
has exact synonym: group
has_obo_namespace: chebi_ontology
has_related_synonym: Gruppe
has_related_synonym: Rest
has_related_synonym: groupe
has_related_synonym: grupo
has_related_synonym: grupos
id: CHEBI:24433
in subset: 3 STAR

halogen molecular entity
type: Class
subclass of: chemical entity
subclass of: p-block molecular entity
imported from: chebi.owl
has exact synonym: halogen molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: halogen compounds
has_related_synonym: halogen molecular entities
id: CHEBI:24471
in subset: 3 STAR

organic heterocyclic compound
type: Class
subclass of: heteroorganic entity
subclass of: organic cyclic compound
subclass of: heterocyclic compound
definition: A cyclic compound having as ring members atoms of carbon and at least of one other element.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic heterocycle
has_related_synonym: organic heterocyclic compounds
id: CHEBI:24532
in subset: 3 STAR

hormone
type: Class
subclass of: molecular messenger
subclass of: agonist
definition: Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: endocrine
has_related_synonym: hormones
id: CHEBI:24621
in subset: 3 STAR

hydroxides
type: Class
subclass of: oxygen molecular entity
subclass of: hydrogen molecular entity
subclass of: heteroatomic molecular entity
definition: Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)).
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:24651
in subset: 3 STAR

hydroxy carboxylic acid
type: Class
subclass of: carbon group molecular entity
subclass of: organic hydroxy compound
definition: Any carboxylic acid with at least one hydroxy group.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: hydroxy carboxylic acids
has_related_synonym: hydroxycarboxylic acid
has_related_synonym: hydroxycarboxylic acids
id: CHEBI:24669
in subset: 3 STAR

oxoacid
type: Class
subclass of: hydroxides
definition: A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
imported from: chebi.owl
has exact synonym: oxoacid
has exact synonym: oxoacids
has_obo_namespace: chebi_ontology
has_related_synonym: oxacids
has_related_synonym: oxiacids
has_related_synonym: oxo acid
has_related_synonym: oxy-acids
has_related_synonym: oxyacids
id: CHEBI:24833
in subset: 3 STAR

ion
type: Class
subclass of: chemical entity
definition: A molecular entity having a net electric charge.
imported from: chebi.owl
has exact synonym: Ion
has exact synonym: ion
has_obo_namespace: chebi_ontology
has_related_synonym: Ionen
has_related_synonym: iones
has_related_synonym: ions
id: CHEBI:24870
in subset: 3 STAR

isoprenoid
type: Class
subclass of: lipid
definition: Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives.
imported from: chebi.owl
database cross reference: LIPID_MAPS_class:LMPR01
database cross reference: PMID:12769708
database cross reference: PMID:19219049
has exact synonym: isoprenoid
has exact synonym: isoprenoids
has_obo_namespace: chebi_ontology
has_related_synonym: isoprenoids
id: CHEBI:24913
in subset: 3 STAR

lactone
type: Class
subclass of: carboxylic ester
subclass of: ester
subclass of: oxacycle
definition: Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
imported from: chebi.owl
has exact synonym: lactone
has exact synonym: lactones
has_obo_namespace: chebi_ontology
has_related_synonym: Lacton
has_related_synonym: Lakton
has_related_synonym: Laktone
has_related_synonym: lactona
has_related_synonym: lactonas
id: CHEBI:25000
in subset: 3 STAR

lead atom
type: Class
subclass of: atom
imported from: chebi.owl
charge: 0
formula: Pb
inchi: InChI=1S/Pb
inchikey: WABPQHHGFIMREM-UHFFFAOYSA-N
mass: 207.20000
monoisotopicmass: 207.97665
smiles: [Pb]
database cross reference: KEGG:C06696
database cross reference: WebElements:Pb
has exact synonym: lead
has_obo_namespace: chebi_ontology
has_related_synonym: 82Pb
has_related_synonym: Blei
has_related_synonym: Pb
has_related_synonym: lead
has_related_synonym: plomb
has_related_synonym: plomo
has_related_synonym: plumbum
id: CHEBI:25016
in subset: 3 STAR

leukotriene
type: Class
subclass of: lipid
definition: Any icosanoid from that family of C20 polyunsaturated fatty acids and their derivatives generated by leukocytes from arachidonic acid, each member having four double bonds of which three are conjugated.
imported from: chebi.owl
database cross reference: LIPID_MAPS_class:LMFA0302
database cross reference: PMID:10922142
database cross reference: PMID:15794321
database cross reference: PMID:3001504
database cross reference: PMID:6129158
database cross reference: PMID:6293196
database cross reference: PMID:6311078
database cross reference: PMID:8842590
database cross reference: PMID:9526099
database cross reference: PMID:9561094
has exact synonym: Leukotriene
has exact synonym: leukotriene
has exact synonym: leukotrienes
has_obo_namespace: chebi_ontology
has_related_synonym: Leukotrien
has_related_synonym: leucotriene
has_related_synonym: leucotrienes
has_related_synonym: leukotrienes
id: CHEBI:25029
in subset: 3 STAR

mevalonic acid
type: Class
subclass of: hydroxy carboxylic acid
definition: A dihydroxy monocarboxylic acid comprising valeric acid having two hydroxy groups at the 3- and 5-positions together with a methyl group at the 3-position.
imported from: chebi.owl
charge: 0
formula: C6H12O4
inchi: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)
inchikey: KJTLQQUUPVSXIM-UHFFFAOYSA-N
mass: 148.15708
monoisotopicmass: 148.07356
smiles: CC(O)(CCO)CC(O)=O
database cross reference: Beilstein:1722595
database cross reference: HMDB:HMDB0000227
database cross reference: PMID:22770225
database cross reference: Reaxys:1722595
has exact synonym: 3,5-dihydroxy-3-methylpentanoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: DL-Mevalonic acid
has_related_synonym: MVA
has_related_synonym: RS-Mevalonic acid
id: CHEBI:25351
in subset: 3 STAR

molecule
type: Class
subclass of: polyatomic entity
definition: Any polyatomic entity that is an electrically neutral entity consisting of more than one atom.
imported from: chebi.owl
has exact synonym: molecule
has_obo_namespace: chebi_ontology
has_related_synonym: Molekuel
has_related_synonym: molecula
has_related_synonym: molecules
has_related_synonym: neutral molecular compounds
id: CHEBI:25367
in subset: 3 STAR

monocarboxylic acid
type: Class
subclass of: carboxylic acid
definition: An oxoacid containing a single carboxy group.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: monocarboxylic acids
id: CHEBI:25384
in subset: 3 STAR

nucleoside phosphate
type: Class
subclass of: organic phosphate
subclass of: phosphoric ester
subclass of: nucleobase-containing molecular entity
definition: A nucleobase-containing molecular entity that is a nucleoside in which one or more of the sugar hydroxy groups has been converted into a mono- or poly-phosphate. The term includes both nucleotides and non-nucleotide nucleoside phosphates.
imported from: chebi.owl
database cross reference: KEGG:C01329
has_obo_namespace: chebi_ontology
has_related_synonym: NMP
has_related_synonym: Nucleoside monophosphate
has_related_synonym: nucleoside phosphates
id: CHEBI:25608
in subset: 3 STAR

omega-3 fatty acid
type: Class
subclass of: fatty acid
definition: A family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the omega-3 position, i.e., the third bond from the methyl end of the fatty acid.
imported from: chebi.owl
database cross reference: PMID:15129302
database cross reference: PMID:15253883
database cross reference: PMID:15555528
database cross reference: PMID:16741195
database cross reference: PMID:19154523
database cross reference: PMID:19439966
database cross reference: PMID:21975796
database cross reference: PMID:23643471
database cross reference: PMID:24012777
database cross reference: PMID:24122252
database cross reference: PMID:24128563
database cross reference: PMID:24172034
database cross reference: PMID:24211484
database cross reference: PMID:24240437
database cross reference: PMID:24246761
database cross reference: PMID:24281905
database cross reference: PMID:24397938
database cross reference: PMID:24401220
database cross reference: PMID:24418228
database cross reference: Wikipedia:Omega-3_fatty_acid
has exact synonym: omega-3 fatty acid
has_obo_namespace: chebi_ontology
has_related_synonym: n-3 fatty acid
has_related_synonym: n-3 fatty acids
has_related_synonym: omega-3 fatty acids
id: CHEBI:25681
in subset: 3 STAR

organic heteromonocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: heteromonocyclic compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic heteromonocyclic compounds
id: CHEBI:25693
in subset: 3 STAR

ether
type: Class
subclass of: carbon group molecular entity
definition: An organooxygen compound with formula ROR, where R is not hydrogen.
imported from: chebi.owl
charge: 0
formula: OR2
mass: 15.99940
monoisotopicmass: 15.99491
smiles: [*]O[*]
has exact synonym: ether
has exact synonym: ethers
has_obo_namespace: chebi_ontology
has_related_synonym: ethers
id: CHEBI:25698
in subset: 3 STAR

organic phosphate
type: Class
subclass of: organophosphorus compound
subclass of: phosphate
subclass of: phosphoric acid derivative
imported from: chebi.owl
database cross reference: Wikipedia:Organophosphate
has exact synonym: organic phosphate
has_obo_namespace: chebi_ontology
has_related_synonym: organic phosphate ester
has_related_synonym: organic phosphate esters
has_related_synonym: organic phosphates
has_related_synonym: organophosphate ester
has_related_synonym: organophosphate esters
id: CHEBI:25703
in subset: 3 STAR

organophosphorus compound
type: Class
subclass of: phosphorus molecular entity
subclass of: heteroorganic entity
subclass of: pnictogen molecular entity
subclass of: carbon group molecular entity
definition: An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters.
imported from: chebi.owl
database cross reference: Wikipedia:Organophosphorus_compound
has exact synonym: organophosphorus compound
has_obo_namespace: chebi_ontology
has_related_synonym: organophosphorus compounds
id: CHEBI:25710
in subset: 3 STAR

oxygen molecular entity
type: Class
subclass of: chalcogen molecular entity
imported from: chebi.owl
has exact synonym: oxygen molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: oxygen molecular entities
id: CHEBI:25806
in subset: 3 STAR

aldopentose phosphate
type: Class
subclass of: aldose phosphate
subclass of: pentose phosphate
imported from: chebi.owl
has exact synonym: aldopentose phosphate
has_obo_namespace: chebi_ontology
has_related_synonym: aldopentose phosphates
id: CHEBI:25900
in subset: 3 STAR

peroxynitrite
type: Class
subclass of: ion
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
definition: The nitrogen oxoanion formed by loss of a proton from peroxynitrous acid.
imported from: chebi.owl
charge: -1
formula: NO3
inchi: InChI=1S/HNO3/c2-1-4-3/h3H/p-1
inchikey: CMFNMSMUKZHDEY-UHFFFAOYSA-M
mass: 62.00494
monoisotopicmass: 61.98837
smiles: [O-]ON=O
database cross reference: CAS:19059-14-4
database cross reference: Gmelin:674445
database cross reference: KEGG:C16845
database cross reference: PMID:29051068
database cross reference: Wikipedia:Peroxynitrite
has exact synonym: azoperoxoite
has exact synonym: oxidoperoxidonitrate(1-)
has exact synonym: peroxynitrite
has_obo_namespace: chebi_ontology
has_related_synonym: [NO(OO)](-)
id: CHEBI:25941
in subset: 3 STAR

phosphate
type: Class
subclass of: phosphoric acid derivative
definition: Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom.
imported from: chebi.owl
has exact synonym: phosphates
has_obo_namespace: chebi_ontology
has_related_synonym: phosphates
id: CHEBI:26020
in subset: 3 STAR

phosphoric acid derivative
type: Class
subclass of: phosphorus oxoacid derivative
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:26079
in subset: 1 STAR

phosphorus molecular entity
type: Class
subclass of: pnictogen molecular entity
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: phosphorus molecular entities
id: CHEBI:26082
in subset: 3 STAR

polar amino acid
type: Class
subclass of: organonitrogen compound
definition: Any amino acid whose side chain is capable of forming one or more hydrogen bonds.
imported from: chebi.owl
charge: 0
formula: C2H4NO2R
mass: 74.059
monoisotopicmass: 74.02420
smiles: OC(C(*)N)=O
has_alternative_id: CHEBI:8283
database cross reference: MetaCyc:Polar-amino-acids
database cross reference: PMID:12016058
has exact synonym: polar amino acid
has_obo_namespace: chebi_ontology
has_related_synonym: polar amino acids
has_related_synonym: polar amino-acid
has_related_synonym: polar amino-acids
id: CHEBI:26167
in subset: 3 STAR

polyol
type: Class
subclass of: organic hydroxy compound
definition: A compound that contains two or more hydroxy groups.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: polyols
id: CHEBI:26191
in subset: 3 STAR

polyunsaturated fatty acid
type: Class
subclass of: fatty acid
definition: Any fatty acid containing more than one double bond. Acids in this group are reported to have cardioprotective effects; and levels are lowered in chronic fatigue syndrome.
imported from: chebi.owl
database cross reference: PMID:14977874
database cross reference: PMID:16380690
database cross reference: PMID:17891522
has_obo_namespace: chebi_ontology
has_related_synonym: PUFA
has_related_synonym: PUFAs
has_related_synonym: polyunsaturated fatty acids
id: CHEBI:26208
in subset: 3 STAR

ambenonium
type: Class
subclass of: ion
definition: A symmetrical oxalamide-based bis-quaternary ammonium ion having ethyl and 2-chlorobenzyl groups attached to the nitrogens.
imported from: chebi.owl
charge: +2
formula: C28H42Cl2N4O2
inchikey: OMHBPUNFVFNHJK-UHFFFAOYSA-P
mass: 537.56500
monoisotopicmass: 536.26738
smiles: CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl
database cross reference: Beilstein:4168740
database cross reference: CAS:7648-98-8
database cross reference: DrugBank:DB01122
database cross reference: Drug_Central:146
database cross reference: KEGG:C07773
database cross reference: Wikipedia:Ambenonium
has exact synonym: 2,2'-[(1,2-dioxoethane-1,2-diyl)diimino]bis[N-(2-chlorobenzyl)-N,N-diethylethanaminium]
has exact synonym: Ambenonium
has_obo_namespace: chebi_ontology
has_related_synonym: Ambenonium Base
has_related_synonym: Ambenonum
id: CHEBI:2627
in subset: 3 STAR

pteridines
type: Class
subclass of: organic heterobicyclic compound
subclass of: heteroarene
subclass of: organonitrogen heterocyclic compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:26373
in subset: 3 STAR

pterins
type: Class
subclass of: pteridines
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:26375
in subset: 3 STAR

purine nucleotide
type: Class
subclass of: purines
subclass of: nucleotide
definition: Any nucleotide that has a purine nucleobase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: purine nucleotides
id: CHEBI:26395
in subset: 3 STAR

purine ribonucleotide
type: Class
subclass of: purine nucleotide
subclass of: ribonucleotide
definition: Any ribonucleotide that has a purine nucleobase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: purine ribonucleotides
id: CHEBI:26400
in subset: 3 STAR

purines
type: Class
subclass of: imidazopyrimidine
definition: A class of imidazopyrimidines that consists of purine and its substituted derivatives.
imported from: chebi.owl
charge: 0
formula: C5N4R7
mass: 116.080
monoisotopicmass: 116.01230
has_alternative_id: CHEBI:13678
has_obo_namespace: chebi_ontology
id: CHEBI:26401
in subset: 3 STAR

retinoic acid
type: Class
subclass of: isoprenoid
definition: A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).
imported from: chebi.owl
charge: 0
formula: C20H28O2
inchi: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)
inchikey: SHGAZHPCJJPHSC-UHFFFAOYSA-N
mass: 300.43512
monoisotopicmass: 300.20893
database cross reference: LINCS:LSM-2135
database cross reference: PMID:24506204
has exact synonym: 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
has_obo_namespace: chebi_ontology
id: CHEBI:26536
in subset: 3 STAR

ribonucleotide
type: Class
subclass of: ribose phosphate
subclass of: nucleotide
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ribonucleotides
id: CHEBI:26561
in subset: 3 STAR

ribose phosphate
type: Class
subclass of: aldopentose phosphate
imported from: chebi.owl
has exact synonym: ribose phosphate
has_obo_namespace: chebi_ontology
has_related_synonym: ribose phosphates
id: CHEBI:26562
in subset: 3 STAR

sesquiterpenoid
type: Class
subclass of: lipid
definition: Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
imported from: chebi.owl
database cross reference: LIPID_MAPS_class:LMPR0103
has_obo_namespace: chebi_ontology
has_related_synonym: sesquiterpenoides
has_related_synonym: sesquiterpenoids
id: CHEBI:26658
in subset: 3 STAR

amitriptyline
type: Class
subclass of: organonitrogen compound
subclass of: organic molecule
definition: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
imported from: chebi.owl
charge: 0
formula: C20H23N
inchi: InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
inchikey: KRMDCWKBEZIMAB-UHFFFAOYSA-N
mass: 277.40336
monoisotopicmass: 277.18305
smiles: CN(C)CCC=C1c2ccccc2CCc2ccccc12
database cross reference: Beilstein:2217885
database cross reference: CAS:50-48-6
database cross reference: DrugBank:DB00321
database cross reference: Drug_Central:180
database cross reference: HMDB:HMDB0014466
database cross reference: KEGG:C06824
database cross reference: KEGG:D07448
database cross reference: LINCS:LSM-3190
database cross reference: PMID:15554244
database cross reference: PMID:18359012
database cross reference: PMID:24447704
database cross reference: Patent:CN101780063
database cross reference: Patent:WO2011089289
database cross reference: Reaxys:2217885
database cross reference: VSDB:2962
database cross reference: Wikipedia:Amitriptyline
has exact synonym: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine
has exact synonym: Amitriptyline
has_obo_namespace: chebi_ontology
has_related_synonym: 10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene
has_related_synonym: 10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine
has_related_synonym: 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
has_related_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine
has_related_synonym: 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene
has_related_synonym: 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene
has_related_synonym: 5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptadiene
has_related_synonym: Amitriptylin
id: CHEBI:2666
in subset: 3 STAR

sphingolipid
type: Class
subclass of: lipid
subclass of: organonitrogen compound
definition: Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: sphingolipids
id: CHEBI:26739
in subset: 3 STAR

amoxapine
type: Class
subclass of: carbon group molecular entity
definition: A dibenzooxazepine compound having a chloro substituent at the 2-position and a piperazin-1-yl group at the 11-position.
imported from: chebi.owl
charge: 0
formula: C17H16ClN3O
inchi: InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
inchikey: QWGDMFLQWFTERH-UHFFFAOYSA-N
mass: 313.78100
monoisotopicmass: 313.09819
smiles: Clc1ccc2Oc3ccccc3N=C(N3CCNCC3)c2c1
database cross reference: Beilstein:832057
database cross reference: CAS:14028-44-5
database cross reference: DrugBank:DB00543
database cross reference: Drug_Central:191
database cross reference: KEGG:D00228
database cross reference: LINCS:LSM-2021
database cross reference: Patent:FR1508536
database cross reference: Patent:US3663696
database cross reference: Wikipedia:Amoxapine
has exact synonym: 2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine
has_related_synonym: Desmethylloxapin
has_related_synonym: amoxapina
has_related_synonym: amoxapine
has_related_synonym: amoxapinum
id: CHEBI:2675
in subset: 3 STAR

steroid hormone
type: Class
subclass of: lipid
definition: Any steroid that acts as hormone.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Steroidhormon
has_related_synonym: Steroidhormone
has_related_synonym: hormona esteroide
has_related_synonym: hormonas esteroideas
has_related_synonym: hormone steroide
has_related_synonym: hormones steroides
has_related_synonym: steroid hormones
id: CHEBI:26764
in subset: 3 STAR

succinate
type: Class
subclass of: ion
subclass of: chalcogen molecular entity
subclass of: carbon group molecular entity
subclass of: polyatomic entity
definition: A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of succinic acid.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: succinate anion
has_related_synonym: succinates
has_related_synonym: succinic acid anion
id: CHEBI:26806
in subset: 3 STAR

carbohydrate phosphate
type: Class
subclass of: organic phosphate
subclass of: phosphoric ester
subclass of: carbohydrate derivative
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: carbohydrate phosphates
id: CHEBI:26816
in subset: 3 STAR

sulfur molecular entity
type: Class
subclass of: chalcogen molecular entity
imported from: chebi.owl
has exact synonym: sulfur molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: sulfur molecular entities
id: CHEBI:26835
in subset: 3 STAR

thiocarboxylic ester
type: Class
subclass of: organosulfur compound
subclass of: ester
definition: An ester in which one or both oxygens of an ester group have been replaced by divalent sulfur.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: thiocarboxylic esters
id: CHEBI:26959
in subset: 3 STAR

thiosulfate
type: Class
subclass of: chalcogen molecular entity
subclass of: polyatomic entity
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:26977
in subset: 1 STAR

organic heterobicyclic compound
type: Class
subclass of: heterobicyclic compound
subclass of: organic heteropolycyclic compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: heterobicyclic compounds
has_related_synonym: organic heterobicyclic compounds
id: CHEBI:27171
in subset: 3 STAR

vitamin B6
type: Class
subclass of: organonitrogen compound
definition: Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
imported from: chebi.owl
has exact synonym: Vitamin B6
has_obo_namespace: chebi_ontology
has_related_synonym: vitamin B-6
has_related_synonym: vitamin B6 vitamer
has_related_synonym: vitamin B6 vitamers
has_related_synonym: vitamina B6
has_related_synonym: vitamine B6
has_related_synonym: vitamins B6
id: CHEBI:27306
in subset: 3 STAR

zinc atom
type: Class
subclass of: atom
imported from: chebi.owl
charge: 0
formula: Zn
inchi: InChI=1S/Zn
inchikey: HCHKCACWOHOZIP-UHFFFAOYSA-N
mass: 65.39000
monoisotopicmass: 63.92914
smiles: [Zn]
database cross reference: CAS:7440-66-6
database cross reference: Gmelin:16321
database cross reference: KEGG:C00038
database cross reference: PDBeChem:ZN
database cross reference: WebElements:Zn
has exact synonym: zinc
has_obo_namespace: chebi_ontology
has_related_synonym: 30Zn
has_related_synonym: Zink
has_related_synonym: Zn
has_related_synonym: Zn(II)
has_related_synonym: Zn2+
has_related_synonym: cinc
has_related_synonym: zinc
has_related_synonym: zincum
id: CHEBI:27363
in subset: 3 STAR

folic acid
type: Class
subclass of: carbon group molecular entity
definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
imported from: chebi.owl
charge: 0
formula: C19H19N7O6
inchi: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
inchikey: OVBPIULPVIDEAO-LBPRGKRZSA-N
mass: 441.39750
monoisotopicmass: 441.13968
has_alternative_id: CHEBI:24075
has_alternative_id: CHEBI:42610
has_alternative_id: CHEBI:5140
has_alternative_id: CHEBI:569217
database cross reference: AGR:IND606960789
database cross reference: Beilstein:100781
database cross reference: CAS:59-30-3
database cross reference: Chemspider:5815
database cross reference: DrugBank:DB00158
database cross reference: Drug_Central:1231
database cross reference: FooDB:FDB014504
database cross reference: HMDB:HMDB0000121
database cross reference: KEGG:C00504
database cross reference: KEGG:D00070
database cross reference: KNApSAcK:C00001539
database cross reference: LINCS:LSM-5355
database cross reference: MetaCyc:CPD-12826
database cross reference: PDBeChem:FOL
database cross reference: PMID:10138938
database cross reference: PMID:10897644
database cross reference: PMID:10958818
database cross reference: PMID:11261364
database cross reference: PMID:11451208
database cross reference: PMID:11959400
database cross reference: PMID:14387833
database cross reference: PMID:15321809
database cross reference: PMID:15523939
database cross reference: PMID:15754725
database cross reference: PMID:15797531
database cross reference: PMID:15797685
database cross reference: PMID:15831910
database cross reference: PMID:15990733
database cross reference: PMID:16093404
database cross reference: PMID:16277678
database cross reference: PMID:16380297
database cross reference: PMID:16871332
database cross reference: PMID:17784727
database cross reference: PMID:18788725
database cross reference: PMID:19121630
database cross reference: PMID:19335717
database cross reference: PMID:19355913
database cross reference: PMID:24650098
database cross reference: PMID:33624660
database cross reference: PMID:33965562
database cross reference: PMID:33968971
database cross reference: PMID:34207319
database cross reference: PMID:34219855
database cross reference: PMID:7738698
database cross reference: PMID:8235383
database cross reference: PMID:9040515
database cross reference: PMID:9420019
database cross reference: PMID:9565830
database cross reference: PMID:9683174
database cross reference: PMID:9781393
database cross reference: PMID:9808640
database cross reference: PMID:9808641
database cross reference: Reaxys:100781
database cross reference: Wikipedia:Folic_Acid
has exact synonym: N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (2S)-2-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzamido)pentanedioic acid
has_related_synonym: Acfol
has_related_synonym: Folate
has_related_synonym: Folicet
has_related_synonym: Folsaeure
has_related_synonym: N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
has_related_synonym: N-pteroyl-L-glutamic acid
has_related_synonym: PGA
has_related_synonym: PteGlu
has_related_synonym: acide folique

prostaglandin G2
type: Class
subclass of: lipid
subclass of: chalcogen molecular entity
subclass of: polyatomic entity
imported from: chebi.owl
charge: 0
formula: C20H32O6
inchi: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
inchikey: SGUKUZOVHSFKPH-YNNPMVKQSA-N
mass: 368.46448
monoisotopicmass: 368.21989
has_alternative_id: CHEBI:26329
has_alternative_id: CHEBI:44869
has_alternative_id: CHEBI:8519
database cross reference: CAS:51982-36-6
database cross reference: DrugBank:DB03866
database cross reference: KEGG:C05956
database cross reference: LIPID_MAPS_instance:LMFA03010009
has exact synonym: (5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroperoxyoct-1-en-1-yl]-2,3-dioxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid
has exact synonym: (5Z,9S,11R,13E,15S)-15-hydroperoxy-9,11-epidioxyprosta-5,13-dien-1-oic acid
has exact synonym: Prostaglandin G2
has_obo_namespace: chebi_ontology
has_related_synonym: PGG2
id: CHEBI:27647
in subset: 3 STAR

methylcobalamin
type: Class
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
subclass of: polyatomic entity
imported from: chebi.owl
charge: 0
formula: C63H91CoN13O14P
inchikey: JEWJRMKHSMTXPP-WZHZPDAFSA-L
mass: 1344.38230
monoisotopicmass: 1343.58780
has_alternative_id: CHEBI:25291
has_alternative_id: CHEBI:48831
has_alternative_id: CHEBI:6869
database cross reference: CAS:13422-55-4
database cross reference: COMe:MOL000085
database cross reference: DrugBank:DB03614
database cross reference: Gmelin:124528
database cross reference: KEGG:C06453
database cross reference: KEGG:D03246
database cross reference: PDBeChem:COB
has exact synonym: Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-methylcobamide
has exact synonym: Methylcobalamin
has exact synonym: methylcobalamin
has_obo_namespace: chebi_ontology
has_related_synonym: CO-METHYLCOBALAMIN
has_related_synonym: MeCbl
has_related_synonym: mecobalamin
has_related_synonym: methylcob(III)alamin
id: CHEBI:28115
in subset: 3 STAR

glutamine
type: Class
subclass of: organonitrogen compound
definition: An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4.
imported from: chebi.owl
charge: 0
formula: C5H10N2O3
inchi: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)
inchikey: ZDXPYRJPNDTMRX-UHFFFAOYSA-N
mass: 146.14458
monoisotopicmass: 146.06914
smiles: NC(CCC(N)=O)C(O)=O
has_alternative_id: CHEBI:24316
has_alternative_id: CHEBI:5432
database cross reference: Beilstein:1723795
database cross reference: CAS:585-21-7
database cross reference: CAS:6899-04-3
database cross reference: Gmelin:27318
database cross reference: KEGG:C00303
database cross reference: KNApSAcK:C00001359
database cross reference: Reaxys:1723795
database cross reference: Wikipedia:Glutamine
has exact synonym: Glutamine
has exact synonym: glutamine
has_obo_namespace: chebi_ontology
has_related_synonym: 2,5-diamino-5-oxopentanoic acid
has_related_synonym: 2-Aminoglutaramic acid
has_related_synonym: 2-amino-4-carbamoylbutanoic acid
has_related_synonym: Glutamin
has_related_synonym: Glutaminsaeure-5-amid
has_related_synonym: Hgln
has_related_synonym: glutamic acid gamma-amide
id: CHEBI:28300
in subset: 3 STAR

allicin
type: Class
subclass of: organosulfur compound
imported from: chebi.owl
charge: 0
formula: C6H10OS2
inchi: InChI=1S/C6H10OS2/c1-3-5-8-9(7)6-4-2/h3-4H,1-2,5-6H2
inchikey: JDLKFOPOAOFWQN-UHFFFAOYSA-N
mass: 162.27500
monoisotopicmass: 162.01731
smiles: C=CCSS(=O)CC=C
has_alternative_id: CHEBI:22356
has_alternative_id: CHEBI:2595
database cross reference: Beilstein:1752823
database cross reference: CAS:539-86-6
database cross reference: KEGG:C07600
database cross reference: KNApSAcK:C00001242
has exact synonym: Allicin
has exact synonym: S-allyl prop-2-ene-1-sulfinothioate
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Propene-1-sulfinothioic acid S-2-propenyl ester
has_related_synonym: thio-2-propene-1-sulfinic acid S-allyl ester
id: CHEBI:28411
in subset: 3 STAR

copper atom
type: Class
subclass of: atom
imported from: chebi.owl
charge: 0
formula: Cu
inchi: InChI=1S/Cu
inchikey: RYGMFSIKBFXOCR-UHFFFAOYSA-N
mass: 63.54600
monoisotopicmass: 62.92960
smiles: [Cu]
has_alternative_id: CHEBI:23376
has_alternative_id: CHEBI:3874
database cross reference: CAS:7440-50-8
database cross reference: Gmelin:16269
database cross reference: KEGG:C00070
database cross reference: WebElements:Cu
has exact synonym: copper
has_obo_namespace: chebi_ontology
has_related_synonym: 29Cu
has_related_synonym: Copper
has_related_synonym: Cu
has_related_synonym: Kupfer
has_related_synonym: cobre
has_related_synonym: copper
has_related_synonym: cuivre
has_related_synonym: cuprum
id: CHEBI:28694
in subset: 3 STAR

serotonin
type: Class
subclass of: organic hydroxy compound
subclass of: organonitrogen compound
definition: A primary amino compound that is the 5-hydroxy derivative of tryptamine.
imported from: chebi.owl
charge: 0
formula: C10H12N2O
inchi: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
inchikey: QZAYGJVTTNCVMB-UHFFFAOYSA-N
mass: 176.215
monoisotopicmass: 176.09496
smiles: C1=CC(=CC=2C(=CNC12)CCN)O
has_alternative_id: CHEBI:1420
has_alternative_id: CHEBI:26652
has_alternative_id: CHEBI:49894
database cross reference: Beilstein:143524
database cross reference: CAS:50-67-9
database cross reference: Gmelin:1861995
database cross reference: HMDB:HMDB0000259
database cross reference: KEGG:C00780
database cross reference: KNApSAcK:C00001429
database cross reference: LINCS:LSM-6589
database cross reference: MetaCyc:SEROTONIN
database cross reference: PDBeChem:SRO
database cross reference: PMID:18593914
database cross reference: PMID:22770225
database cross reference: PMID:24136337
database cross reference: Reaxys:143524
database cross reference: Wikipedia:Serotonin
has exact synonym: 3-(2-aminoethyl)-1H-indol-5-ol
has exact synonym: SEROTONIN
has exact synonym: Serotonin
has_obo_namespace: chebi_ontology
has_related_synonym: 3-(2-Aminoethyl)-1H-indol-5-ol
has_related_synonym: 5-HT
has_related_synonym: 5-Hydroxytryptamine
has_related_synonym: Enteramine
has_related_synonym: serotonine
has_related_synonym: thrombocytin
has_related_synonym: thrombotonin
id: CHEBI:28790
in subset: 3 STAR

3-disulfanyl-L-alanine
type: Class
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
definition: An S-substituted L-cysteine where the S-substituent is specified as sulfanyl.
imported from: chebi.owl
charge: 0
formula: C3H7NO2S2
inchi: InChI=1S/C3H7NO2S2/c4-2(1-8-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1
inchikey: XBKONSCREBSMCS-REOHCLBHSA-N
mass: 153.210
monoisotopicmass: 152.99182
smiles: C([C@H](N)C(=O)O)SS
has_alternative_id: CHEBI:21269
has_alternative_id: CHEBI:41628
has_alternative_id: CHEBI:41711
has_alternative_id: CHEBI:41718
has_alternative_id: CHEBI:41743
has_alternative_id: CHEBI:9551
database cross reference: CAS:5652-32-4
database cross reference: DrugBank:DB02761
database cross reference: KEGG:C01962
database cross reference: PDBeChem:CSS
database cross reference: PMID:10753862
database cross reference: PMID:10760256
database cross reference: PMID:12382038
database cross reference: PMID:12386155
database cross reference: PMID:12686149
database cross reference: PMID:14644425
database cross reference: PMID:16855700
database cross reference: PMID:9099686
database cross reference: PMID:9867829
database cross reference: RESID:AA0269
database cross reference: Reaxys:6381723
has exact synonym: 3-disulfanyl-L-alanine
has_obo_namespace: chebi_ontology
has_related_synonym: (R)-2-amino-3-disulfanylpropanoic acid
has_related_synonym: 2-amino-3-disulfanylpropanoic acid
has_related_synonym: 2-amino-3-hydrodisulfidopropanoic acid
has_related_synonym: 2-amino-3-hydropersulfidopropanoic acid
has_related_synonym: 2-amino-3-persulfhydrylpropanoic acid
has_related_synonym: 3-(thiosulfeno)-alanine
has_related_synonym: S-sulfanylcysteine
has_related_synonym: Thiocysteine
has_related_synonym: cysteine persulfide
has_related_synonym: cysteine perthiol
has_related_synonym: thiocysteine
id: CHEBI:28839
in subset: 3 STAR

aluminium atom
type: Class
subclass of: atom
imported from: chebi.owl
charge: 0
formula: Al
inchi: InChI=1S/Al
inchikey: XAGFODPZIPBFFR-UHFFFAOYSA-N
mass: 26.98154
monoisotopicmass: 26.98154
smiles: [Al]
has_alternative_id: CHEBI:22471
has_alternative_id: CHEBI:2616
database cross reference: CAS:7429-90-5
database cross reference: DrugBank:DB01370
database cross reference: Gmelin:16248
database cross reference: KEGG:C06264
database cross reference: WebElements:Al
has exact synonym: aluminium
has_obo_namespace: chebi_ontology
has_related_synonym: 13Al
has_related_synonym: Al
has_related_synonym: Aluminium
has_related_synonym: aluminio
has_related_synonym: aluminium
has_related_synonym: aluminum
id: CHEBI:28984
in subset: 3 STAR

arginine
type: Class
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
definition: An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.
imported from: chebi.owl
charge: 0
formula: C6H14N4O2
inchi: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)
inchikey: ODKSFYDXXFIFQN-UHFFFAOYSA-N
mass: 174.20112
monoisotopicmass: 174.11168
smiles: NC(CCCNC(N)=N)C(O)=O
has_alternative_id: CHEBI:22616
has_alternative_id: CHEBI:2643
database cross reference: Beilstein:1725411
database cross reference: CAS:7200-25-1
database cross reference: KEGG:C02385
database cross reference: PMID:10848923
database cross reference: Reaxys:1725411
database cross reference: Wikipedia:L-Arginine
has exact synonym: Arginine
has exact synonym: arginine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Amino-5-guanidinovaleric acid
has_related_synonym: 2-amino-5-(carbamimidamido)pentanoic acid
has_related_synonym: 2-amino-5-guanidinopentanoic acid
has_related_synonym: Arginin
has_related_synonym: Harg
id: CHEBI:29016
in subset: 3 STAR

iron(2+)
type: Class
subclass of: ion
imported from: chebi.owl
charge: +2
formula: Fe
inchi: InChI=1S/Fe/q+2
inchikey: CWYNVVGOOAEACU-UHFFFAOYSA-N
mass: 55.84500
monoisotopicmass: 55.93384
smiles: [Fe++]
has_alternative_id: CHEBI:13319
has_alternative_id: CHEBI:13321
has_alternative_id: CHEBI:21129
has_alternative_id: CHEBI:24876
has_alternative_id: CHEBI:34754
has_alternative_id: CHEBI:49599
database cross reference: CAS:15438-31-0
database cross reference: Gmelin:6845
database cross reference: KEGG:C14818
database cross reference: PDBeChem:FE2
has exact synonym: Iron(2+)
has exact synonym: iron(2+)
has exact synonym: iron(2+) ion
has exact synonym: iron(II) cation
has_obo_namespace: chebi_ontology
has_related_synonym: FE (II) ION
has_related_synonym: Fe(2+)
has_related_synonym: Fe(II)
has_related_synonym: Fe2+
has_related_synonym: Ferrous ion
has_related_synonym: iron ion(2+)
id: CHEBI:29033
in subset: 3 STAR

sodium(1+)
type: Class
subclass of: alkali metal molecular entity
definition: A monoatomic monocation obtained from sodium.
imported from: chebi.owl
charge: +1
formula: Na
inchi: InChI=1S/Na/q+1
inchikey: FKNQFGJONOIPTF-UHFFFAOYSA-N
mass: 22.98977
monoisotopicmass: 22.98922
smiles: [Na+]
has_alternative_id: CHEBI:26717
has_alternative_id: CHEBI:49766
has_alternative_id: CHEBI:9175
database cross reference: CAS:17341-25-2
database cross reference: Gmelin:15196
database cross reference: KEGG:C01330
database cross reference: PDBeChem:NA
has exact synonym: sodium cation
has exact synonym: sodium(1+)
has exact synonym: sodium(1+) ion
has exact synonym: sodium(I) cation
has_obo_namespace: chebi_ontology
has_related_synonym: Na(+)
has_related_synonym: Na+
has_related_synonym: SODIUM ION
id: CHEBI:29101
in subset: 3 STAR

potassium(1+)
type: Class
subclass of: alkali metal molecular entity
definition: A monoatomic monocation obtained from potassium.
imported from: chebi.owl
charge: +1
formula: K
inchi: InChI=1S/K/q+1
inchikey: NPYPAHLBTDXSSS-UHFFFAOYSA-N
mass: 39.09830
monoisotopicmass: 38.96316
smiles: [K+]
has_alternative_id: CHEBI:26219
has_alternative_id: CHEBI:49685
has_alternative_id: CHEBI:8345
database cross reference: CAS:24203-36-9
database cross reference: Gmelin:15203
database cross reference: KEGG:C00238
database cross reference: KEGG:D08403
database cross reference: PDBeChem:K
has exact synonym: potassium cation
has exact synonym: potassium(1+)
has exact synonym: potassium(1+) ion
has exact synonym: potassium(I) cation
has_obo_namespace: chebi_ontology
has_related_synonym: K(+)
has_related_synonym: K+
has_related_synonym: POTASSIUM ION
id: CHEBI:29103
in subset: 3 STAR

zinc(2+)
type: Class
subclass of: ion
imported from: chebi.owl
charge: +2
formula: Zn
inchi: InChI=1S/Zn/q+2
inchikey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
mass: 65.39000
monoisotopicmass: 63.92804
smiles: [Zn++]
has_alternative_id: CHEBI:10113
has_alternative_id: CHEBI:27368
has_alternative_id: CHEBI:49972
has_alternative_id: CHEBI:49982
database cross reference: CAS:23713-49-7
database cross reference: Gmelin:6869
database cross reference: KEGG:C00038
database cross reference: PDBeChem:ZN
has exact synonym: zinc(2+)
has exact synonym: zinc(2+) ion
has exact synonym: zinc(II) cation
has_obo_namespace: chebi_ontology
has_related_synonym: ZINC ION
has_related_synonym: Zn(2+)
has_related_synonym: Zn(II)
has_related_synonym: Zn2+
has_related_synonym: dietary zinc
has_related_synonym: zinc cation
has_related_synonym: zinc, ion (Zn2+)
id: CHEBI:29105
in subset: 3 STAR

calcium(2+)
type: Class
subclass of: ion
imported from: chebi.owl
charge: +2
formula: Ca
inchi: InChI=1S/Ca/q+2
inchikey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
mass: 40.07800
monoisotopicmass: 39.96149
smiles: [Ca++]
has_alternative_id: CHEBI:22988
has_alternative_id: CHEBI:3308
has_alternative_id: CHEBI:48760
database cross reference: CAS:14127-61-8
database cross reference: Gmelin:6850
database cross reference: KEGG:C00076
database cross reference: PDBeChem:CA
has exact synonym: calcium(2+)
has exact synonym: calcium(2+) ion
has exact synonym: calcium(II) cation
has_obo_namespace: chebi_ontology
has_related_synonym: CALCIUM ION
has_related_synonym: Ca(2+)
has_related_synonym: Ca2+
has_related_synonym: calcium, doubly charged positive ion
id: CHEBI:29108
in subset: 3 STAR

hydroxyl
type: Class
subclass of: chalcogen molecular entity
subclass of: polyatomic entity
imported from: chebi.owl
charge: 0
formula: HO
inchi: InChI=1S/HO/h1H
inchikey: TUJKJAMUKRIRHC-UHFFFAOYSA-N
mass: 17.00734
monoisotopicmass: 17.00274
smiles: [O][H]
has_alternative_id: CHEBI:24707
has_alternative_id: CHEBI:29190
database cross reference: CAS:3352-57-6
database cross reference: Gmelin:105
database cross reference: KEGG:C16844
has exact synonym: hydridooxygen(.)
has exact synonym: hydroxyl
has exact synonym: oxidanyl
has_obo_namespace: chebi_ontology
has_related_synonym: (OH)(.)
has_related_synonym: HO(.)
has_related_synonym: Hydrogen oxide
has_related_synonym: hydroxyl radical
id: CHEBI:29191
in subset: 3 STAR

acetate
type: Class
subclass of: ion
definition: A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid.
imported from: chebi.owl
charge: -1
formula: C2H3O2
inchi: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1
inchikey: QTBSBXVTEAMEQO-UHFFFAOYSA-M
mass: 59.04402
monoisotopicmass: 59.01385
smiles: CC([O-])=O
has_alternative_id: CHEBI:13704
has_alternative_id: CHEBI:22165
has_alternative_id: CHEBI:40480
database cross reference: Beilstein:1901470
database cross reference: CAS:71-50-1
database cross reference: DrugBank:DB03166
database cross reference: Gmelin:1379
database cross reference: KEGG:C00033
database cross reference: MetaCyc:ACET
database cross reference: PDBeChem:ACT
database cross reference: PMID:17190852
database cross reference: PMID:22211106
database cross reference: PMID:22371380
database cross reference: Reaxys:1901470
database cross reference: UM-BBD_compID:c0050
database cross reference: Wikipedia:Acetate
has exact synonym: acetate
has_obo_namespace: chebi_ontology
has_related_synonym: ACETATE ION
has_related_synonym: Azetat
has_related_synonym: CH3-COO(-)
has_related_synonym: Ethanoat
has_related_synonym: MeCO2 anion
has_related_synonym: acetic acid, ion(1-)
has_related_synonym: ethanoate
id: CHEBI:30089
in subset: 3 STAR

benazepril
type: Class
subclass of: organic molecule
definition: A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
imported from: chebi.owl
charge: 0
formula: C24H28N2O5
inchi: InChI=1S/C24H28N2O5/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28)/t19-,20-/m0/s1
inchikey: XPCFTKFZXHTYIP-PMACEKPBSA-N
mass: 424.48950
monoisotopicmass: 424.19982
database cross reference: CAS:86541-75-5
database cross reference: DrugBank:DB00542
database cross reference: Drug_Central:299
database cross reference: HMDB:HMDB0014682
database cross reference: KEGG:C06843
database cross reference: KEGG:D07499
database cross reference: LINCS:LSM-5609
database cross reference: MetaCyc:CPD-15329
database cross reference: PMID:25224804
database cross reference: PMID:25738503
database cross reference: PMID:25784709
database cross reference: PMID:25912588
database cross reference: Patent:EP72352
database cross reference: Patent:US4410520
database cross reference: Reaxys:4302258
database cross reference: Wikipedia:Benazepril
has exact synonym: Benazepril
has exact synonym: [(3S)-3-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
has_obo_namespace: chebi_ontology
has_related_synonym: 1H-1-Benzazepine-1-acetic acid, 3-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-2,3,4,5-tetrahydro-2-oxo-, (S-(R*,R*))-
has_related_synonym: benazepril
has_related_synonym: benazeprilum
id: CHEBI:3011
in subset: 3 STAR

lithium atom
type: Class
subclass of: atom
imported from: chebi.owl
charge: 0
formula: Li
inchi: InChI=1S/Li
inchikey: WHXSMMKQMYFTQS-UHFFFAOYSA-N
mass: 6.94100
monoisotopicmass: 7.01600
smiles: [Li]
database cross reference: CAS:7439-93-2
database cross reference: WebElements:Li
has exact synonym: lithium
has_obo_namespace: chebi_ontology
has_related_synonym: 3Li
has_related_synonym: Li
has_related_synonym: Lithium
has_related_synonym: lithium
has_related_synonym: litio
id: CHEBI:30145
in subset: 3 STAR

tetrahydropterin
type: Class
subclass of: pterins
imported from: chebi.owl
has_alternative_id: CHEBI:13613
has_alternative_id: CHEBI:26918
has_obo_namespace: chebi_ontology
has_related_synonym: tetrahydropteridines
has_related_synonym: tetrahydropterins
id: CHEBI:30436
in subset: 3 STAR

alcohol
type: Class
subclass of: organic hydroxy compound
definition: A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom.
imported from: chebi.owl
charge: 0
formula: HOR
mass: 17.007
monoisotopicmass: 17.00274
smiles: O[*]
has_alternative_id: CHEBI:13804
has_alternative_id: CHEBI:22288
has_alternative_id: CHEBI:2553
database cross reference: KEGG:C00069
has exact synonym: Alcohol
has exact synonym: alcohols
has_obo_namespace: chebi_ontology
has_related_synonym: an alcohol
id: CHEBI:30879
in subset: 3 STAR

bile acid
type: Class
subclass of: lipid
definition: Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration.
imported from: chebi.owl
database cross reference: KEGG:C01558
has exact synonym: Bile acid
has_obo_namespace: chebi_ontology
has_related_synonym: 5beta-bile acid
has_related_synonym: 5beta-bile acids
has_related_synonym: Bile salt
has_related_synonym: Gallensaeure
has_related_synonym: Gallensaeuren
has_related_synonym: bile acids
id: CHEBI:3098
in subset: 3 STAR

aripiprazole
type: Class
subclass of: antipsychotic agent
definition: An N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders.
imported from: chebi.owl
charge: 0
formula: C23H27Cl2N3O2
inchikey: CEUORZQYGODEFX-UHFFFAOYSA-N
mass: 448.390
monoisotopicmass: 447.14803
database cross reference: CAS:129722-12-9
database cross reference: Chemspider:54790
database cross reference: DrugBank:DB01238
database cross reference: Drug_Central:242
database cross reference: FooDB:FDB004879
database cross reference: HMDB:HMDB0005042
database cross reference: KEGG:C12564
database cross reference: KEGG:D01164
database cross reference: LINCS:LSM-5776
database cross reference: PDBeChem:9SC
database cross reference: PMID:12063084
database cross reference: PMID:12784105
database cross reference: PMID:14998222
database cross reference: PMID:15019558
database cross reference: PMID:15189766
database cross reference: PMID:15257633
database cross reference: PMID:15825673
database cross reference: PMID:16401666
database cross reference: PMID:16508892
database cross reference: PMID:16554739
database cross reference: PMID:16648324
database cross reference: PMID:16880478
database cross reference: PMID:17115868
database cross reference: PMID:17472545
database cross reference: PMID:17501690
database cross reference: PMID:18021764
database cross reference: PMID:18646161
database cross reference: PMID:18720421
database cross reference: PMID:18765484
database cross reference: PMID:18788833
database cross reference: PMID:19412463
database cross reference: PMID:19956463
database cross reference: PMID:20201815
database cross reference: PMID:30292748
database cross reference: PMID:30411049
database cross reference: PMID:30856161
database cross reference: PMID:31152368
database cross reference: PMID:31320322
database cross reference: PMID:32891516
database cross reference: PMID:33064050
database cross reference: PMID:33347031
database cross reference: Patent:EP367141
database cross reference: Patent:US5006528
database cross reference: Wikipedia:Aripiprazole
has exact synonym: 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
has_obo_namespace: chebi_ontology
has_related_synonym: 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone
has_related_synonym: 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
has_related_synonym: 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one
has_related_synonym: Abilify
has_related_synonym: Abilify Discmelt
has_related_synonym: Abilify Maintena
has_related_synonym: Abilify MyCite
has_related_synonym: Abilitat
has_related_synonym: Arpizol
has_related_synonym: Asprito
has_related_synonym: Discmelt
has_related_synonym: OPC 14597
has_related_synonym: OPC 31
has_related_synonym: OPC-14597
has_related_synonym: OPC-31
has_related_synonym: Pripiprazole
has_related_synonym: aripiprazol
has_related_synonym: aripiprazole
has_related_synonym: aripiprazolum
id: CHEBI:31236
in subset: 3 STAR

Blonanserin
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
charge: 0
formula: C23H30FN3
inchi: InChI=1S/C23H30FN3/c1-2-26-13-15-27(16-14-26)23-17-21(18-9-11-19(24)12-10-18)20-7-5-3-4-6-8-22(20)25-23/h9-12,17H,2-8,13-16H2,1H3
inchikey: XVGOZDAJGBALKS-UHFFFAOYSA-N
mass: 367.504
monoisotopicmass: 367.24238
database cross reference: CAS:132810-10-7
database cross reference: Drug_Central:388
database cross reference: KEGG:D01176
has exact synonym: Blonanserin
has_obo_namespace: chebi_ontology
has_related_synonym: AD 5423
has_related_synonym: AD-5423
has_related_synonym: lonasen
id: CHEBI:31296
in subset: 2 STAR

idebenone
type: Class
subclass of: ketone
definition: A member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.
imported from: chebi.owl
charge: 0
formula: C19H30O5
inchi: InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
inchikey: JGPMMRGNQUBGND-UHFFFAOYSA-N
mass: 338.444
monoisotopicmass: 338.20932
smiles: COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O
database cross reference: CAS:58186-27-9
database cross reference: Chemspider:3558
database cross reference: DrugBank:DB09081
database cross reference: Drug_Central:1416
database cross reference: KEGG:D01750
database cross reference: LINCS:LSM-5505
database cross reference: PMID:11207459
database cross reference: PMID:15374364
database cross reference: PMID:18045357
database cross reference: PMID:18710357
database cross reference: PMID:19283347
database cross reference: PMID:19283350
database cross reference: PMID:20955109
database cross reference: PMID:22269948
database cross reference: PMID:23859348
database cross reference: PMID:2669658
database cross reference: PMID:30726629
database cross reference: PMID:32111141
database cross reference: PMID:33247801
database cross reference: PMID:33254077
database cross reference: PMID:33628024
database cross reference: PMID:7981485
database cross reference: PMID:7988944
database cross reference: Patent:DE2519730
database cross reference: Patent:US4271083
database cross reference: Reaxys:2001459
database cross reference: Wikipedia:Idebenone
has exact synonym: 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone
has_obo_namespace: chebi_ontology
has_related_synonym: 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone
has_related_synonym: 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone
has_related_synonym: 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
has_related_synonym: 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone
has_related_synonym: 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinone
has_related_synonym: CV 2619
has_related_synonym: CV-2619
has_related_synonym: Raxone
has_related_synonym: idebenona
has_related_synonym: idebenone
has_related_synonym: idebenonum
id: CHEBI:31687
in subset: 3 STAR

sulpiride
type: Class
subclass of: organosulfur compound
subclass of: organonitrogen compound
definition: A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.
imported from: chebi.owl
charge: 0
formula: C15H23N3O4S
inchi: InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)
inchikey: BGRJTUBHPOOWDU-UHFFFAOYSA-N
mass: 341.42600
monoisotopicmass: 341.14093
smiles: CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O
database cross reference: CAS:15676-16-1
database cross reference: DrugBank:DB00391
database cross reference: Drug_Central:2537
database cross reference: KEGG:D01226
database cross reference: LINCS:LSM-5080
database cross reference: PMID:16327907
database cross reference: PMID:16924461
database cross reference: PMID:17912501
database cross reference: PMID:17942035
database cross reference: PMID:18757738
database cross reference: PMID:18985321
database cross reference: PMID:19370694
database cross reference: PMID:19546258
database cross reference: PMID:19672580
database cross reference: PMID:19864199
database cross reference: PMID:19941957
database cross reference: PMID:20061345
database cross reference: PMID:20091661
database cross reference: PMID:20177884
database cross reference: PMID:20304506
database cross reference: PMID:20305607
database cross reference: PMID:20538381
database cross reference: PMID:20599913
database cross reference: PMID:20875676
database cross reference: Patent:DE2903891
database cross reference: Patent:US3342826
database cross reference: Reaxys:494008
database cross reference: Wikipedia:Sulpiride
has exact synonym: N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-sulpiride
has_related_synonym: 5-(Aminosulfonyl)-N-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxybenzamide
has_related_synonym: N-((1-Ethyl-2-pyrrolidinyl)methyl)-2-methoxy-5-sulfamoylbenzamide
has_related_synonym: N-((1-Ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide
has_related_synonym: Sulpirid
has_related_synonym: Sulpyrid
has_related_synonym: sulpirida
has_related_synonym: sulpiride
has_related_synonym: sulpiridum
id: CHEBI:32168
in subset: 3 STAR

tenoxicam
type: Class
subclass of: organonitrogen compound
definition: A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. It is also indicated for short term treatment of acute musculoskeletal disorders including strains, sprains and other soft-tissue injuries.
imported from: chebi.owl
charge: 0
formula: C13H11N3O4S2
inchi: InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
inchikey: LZNWYQJJBLGYLT-UHFFFAOYSA-N
mass: 337.37400
monoisotopicmass: 337.01910
database cross reference: CAS:59804-37-4
database cross reference: DrugBank:DB00469
database cross reference: Drug_Central:2595
database cross reference: KEGG:D01767
database cross reference: PMID:21129461
database cross reference: PMID:21327813
database cross reference: PMID:21682312
database cross reference: PMID:21712619
database cross reference: PMID:21777594
database cross reference: PMID:21929527
database cross reference: PMID:21981557
database cross reference: PMID:22095696
database cross reference: PMID:22182582
database cross reference: PMID:22306394
database cross reference: PMID:22675955
database cross reference: PMID:22841852
database cross reference: PMID:22876956
database cross reference: PMID:23204620
database cross reference: PMID:23273940
database cross reference: PMID:23340327
database cross reference: PMID:23480456
database cross reference: PMID:23656309
database cross reference: PMID:23932198
database cross reference: PMID:24037655
database cross reference: PMID:24093711
database cross reference: PMID:28166217
database cross reference: Patent:US2008014272
database cross reference: Patent:US4687766
database cross reference: Reaxys:572193
database cross reference: Wikipedia:Tenoxicam
has exact synonym: 4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
has_obo_namespace: chebi_ontology
has_related_synonym: Mobiflex
has_related_synonym: Tilcotil
has_related_synonym: tenoxicam
has_related_synonym: tenoxicamum
id: CHEBI:32192
in subset: 3 STAR

amide
type: Class
subclass of: nitrogen molecular entity
definition: An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
imported from: chebi.owl
has_alternative_id: CHEBI:22473
has_alternative_id: CHEBI:2633
database cross reference: KEGG:C00241
has exact synonym: Amide
has exact synonym: amides
has_obo_namespace: chebi_ontology
id: CHEBI:32988
in subset: 3 STAR

vitamin (role)
type: Class
subclass of: biochemical role
subclass of: food component
definition: A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term "vitamines" (from vita + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines.
imported from: chebi.owl
has_alternative_id: CHEBI:10004
has_alternative_id: CHEBI:27305
database cross reference: Wikipedia:Vitamin
has_obo_namespace: chebi_ontology
has_related_synonym: vitamin
has_related_synonym: vitamina
has_related_synonym: vitaminas
has_related_synonym: vitamine
has_related_synonym: vitamines
has_related_synonym: vitamins
has_related_synonym: vitaminum
id: CHEBI:33229
in subset: 3 STAR

application
type: Class
subclass of: role
definition: Intended use of the molecular entity or part thereof by humans.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:33232
in subset: 3 STAR

vitamin E
type: Class
subclass of: carbon group molecular entity
definition: Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
imported from: chebi.owl
database cross reference: MetaCyc:Vitamin-E
database cross reference: PMID:33684201
database cross reference: PMID:33847203
database cross reference: PMID:33896432
database cross reference: PMID:34277234
database cross reference: PMID:34278890
database cross reference: PMID:7898412
database cross reference: PMID:7901680
database cross reference: Wikipedia:Vitamin_E
has exact synonym: vitamin E
has_obo_namespace: chebi_ontology
has_related_synonym: vitamin E vitamer
has_related_synonym: vitamin E vitamers
has_related_synonym: vitamin-E
has_related_synonym: vitamins E
id: CHEBI:33234
in subset: 3 STAR

oxoacid derivative
type: Class
subclass of: heteroatomic molecular entity
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: oxoacid derivatives
id: CHEBI:33241
in subset: 3 STAR

atom
type: Class
subclass of: chemical entity
definition: A chemical entity constituting the smallest component of an element having the chemical properties of the element.
imported from: chebi.owl
has_alternative_id: CHEBI:22671
has_alternative_id: CHEBI:23907
has exact synonym: atom
has_obo_namespace: chebi_ontology
has_related_synonym: atome
has_related_synonym: atomo
has_related_synonym: atoms
has_related_synonym: atomus
has_related_synonym: element
has_related_synonym: elements
id: CHEBI:33250
in subset: 3 STAR

primary amide
type: Class
subclass of: amide
definition: A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
imported from: chebi.owl
has exact synonym: primary amide
has exact synonym: primary amides
has_obo_namespace: chebi_ontology
id: CHEBI:33256
in subset: 3 STAR

organosulfur compound
type: Class
subclass of: sulfur molecular entity
subclass of: chalcogen molecular entity
subclass of: carbon group molecular entity
subclass of: organochalcogen compound
definition: An organosulfur compound is a compound containing at least one carbon-sulfur bond.
imported from: chebi.owl
has_alternative_id: CHEBI:23010
has_alternative_id: CHEBI:25714
database cross reference: Wikipedia:Organosulfur_compounds
has exact synonym: organosulfur compound
has_obo_namespace: chebi_ontology
has_related_synonym: organosulfur compounds
id: CHEBI:33261
in subset: 3 STAR

molecular messenger
type: Class
subclass of: biological role
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: chemical messenger
id: CHEBI:33280
in subset: 3 STAR

heteroorganic entity
type: Class
subclass of: organic molecular entity
definition: A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: heteroorganic entities
has_related_synonym: organoelement compounds
id: CHEBI:33285
in subset: 3 STAR

alkali metal molecular entity
type: Class
subclass of: chemical entity
definition: A molecular entity containing one or more atoms of an alkali metal.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: alkali metal molecular entities
id: CHEBI:33296
in subset: 3 STAR

pnictogen molecular entity
type: Class
subclass of: chemical entity
subclass of: p-block molecular entity
definition: A p-block molecular entity containing any pnictogen.
imported from: chebi.owl
has exact synonym: pnictogen molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: pnictogen molecular entities
id: CHEBI:33302
in subset: 3 STAR

chalcogen molecular entity
type: Class
subclass of: chemical entity
subclass of: p-block molecular entity
definition: Any p-block molecular entity containing a chalcogen.
imported from: chebi.owl
has exact synonym: chalcogen molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: chalcogen compounds
has_related_synonym: chalcogen molecular entities
id: CHEBI:33304
in subset: 3 STAR

carboxylic ester
type: Class
subclass of: ester
subclass of: carbonyl compound
definition: An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.
imported from: chebi.owl
charge: 0
formula: CO2R2
mass: 44.010
monoisotopicmass: 43.98983
smiles: [*]C(=O)O[*]
has_alternative_id: CHEBI:13204
has_alternative_id: CHEBI:23028
has_alternative_id: CHEBI:3408
database cross reference: KEGG:C02391
database cross reference: Wikipedia:Ester
has exact synonym: Carboxylic ester
has exact synonym: carboxylic esters
has_obo_namespace: chebi_ontology
has_related_synonym: a carboxylic ester
has_related_synonym: carboxylic acid esters
id: CHEBI:33308
in subset: 3 STAR

phospho sugar
type: Class
subclass of: carbohydrate phosphate
subclass of: monosaccharide derivative
definition: Any monosaccharide containing an alcoholic hydroxy group esterified with phosphoric acid.
imported from: chebi.owl
has_alternative_id: CHEBI:15132
has_alternative_id: CHEBI:25406
has_alternative_id: CHEBI:26086
has_alternative_id: CHEBI:9320
database cross reference: KEGG:C00934
database cross reference: PMID:18186488
has exact synonym: phospho sugar
has_obo_namespace: chebi_ontology
has_related_synonym: monosaccharide phosphates
has_related_synonym: phospho sugars
has_related_synonym: phosphorylated sugar
has_related_synonym: phosphorylated sugars
has_related_synonym: phosphosugar
has_related_synonym: phosphosugars
id: CHEBI:33447
in subset: 3 STAR

catecholamine
type: Class
subclass of: organic hydroxy compound
subclass of: organonitrogen compound
definition: 4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.
imported from: chebi.owl
charge: 0
formula: C8H9NO2R2
mass: 151.163
monoisotopicmass: 151.06333
has_alternative_id: CHEBI:23056
has_alternative_id: CHEBI:3468
database cross reference: KEGG:C02012
has exact synonym: Catecholamine
has exact synonym: catecholamines
has_obo_namespace: chebi_ontology
has_related_synonym: catecholamines
id: CHEBI:33567
in subset: 3 STAR

noradrenaline
type: Class
subclass of: organonitrogen compound
definition: A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted.
imported from: chebi.owl
charge: 0
formula: C8H11NO3
inchi: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2
inchikey: SFLSHLFXELFNJZ-UHFFFAOYSA-N
mass: 169.17788
monoisotopicmass: 169.07389
smiles: NCC(O)c1ccc(O)c(O)c1
database cross reference: Beilstein:2210994
database cross reference: CAS:138-65-8
database cross reference: Gmelin:863925
database cross reference: LINCS:LSM-5181
has exact synonym: 4-(2-amino-1-hydroxyethyl)benzene-1,2-diol
has_obo_namespace: chebi_ontology
has_related_synonym: noradrenalina
has_related_synonym: norepinephrine
id: CHEBI:33569
in subset: 3 STAR

carboxylic acid
type: Class
subclass of: carbon oxoacid
subclass of: carbonyl compound
subclass of: organic acid
definition: A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
imported from: chebi.owl
charge: 0
formula: CHO2R
mass: 45.01740
monoisotopicmass: 44.99765
smiles: OC([*])=O
has_alternative_id: CHEBI:13428
has_alternative_id: CHEBI:13627
has_alternative_id: CHEBI:23027
database cross reference: PMID:17147560
database cross reference: PMID:18433345
database cross reference: Wikipedia:Carboxylic_acid
has exact synonym: carboxylic acid
has exact synonym: carboxylic acids
has_obo_namespace: chebi_ontology
has_related_synonym: Carbonsaeure
has_related_synonym: Carbonsaeuren
has_related_synonym: Karbonsaeure
has_related_synonym: RC(=O)OH
has_related_synonym: acide carboxylique
has_related_synonym: acides carboxyliques
has_related_synonym: acido carboxilico
has_related_synonym: acidos carboxilicos
id: CHEBI:33575
in subset: 3 STAR

main group molecular entity
type: Class
subclass of: molecular entity
definition: A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: main group compounds
has_related_synonym: main group molecular entities
id: CHEBI:33579
in subset: 3 STAR

carbon group molecular entity
type: Class
subclass of: chemical entity
subclass of: p-block molecular entity
imported from: chebi.owl
has exact synonym: carbon group molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: carbon group molecular entities
id: CHEBI:33582
in subset: 3 STAR

cyclic compound
type: Class
subclass of: molecule
definition: Any molecule that consists of a series of atoms joined together to form a ring.
imported from: chebi.owl
database cross reference: Wikipedia:Cyclic_compound
has_obo_namespace: chebi_ontology
has_related_synonym: cyclic compounds
id: CHEBI:33595
in subset: 3 STAR

homocyclic compound
type: Class
subclass of: cyclic compound
definition: A cyclic compound having as ring members atoms of the same element only.
imported from: chebi.owl
has exact synonym: homocyclic compound
has exact synonym: homocyclic compounds
has_obo_namespace: chebi_ontology
has_related_synonym: isocyclic compounds
id: CHEBI:33597
in subset: 3 STAR

carbocyclic compound
type: Class
subclass of: homocyclic compound
subclass of: organic cyclic compound
definition: A homocyclic compound in which all of the ring members are carbon atoms.
imported from: chebi.owl
has exact synonym: carbocyclic compound
has exact synonym: carbocyclic compounds
has_obo_namespace: chebi_ontology
has_related_synonym: carbocycle
id: CHEBI:33598
in subset: 3 STAR

hydrogen molecular entity
type: Class
subclass of: s-block molecular entity
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: hydrogen compounds
has_related_synonym: hydrogen molecular entities
id: CHEBI:33608
in subset: 3 STAR

polycyclic compound
type: Class
subclass of: cyclic compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: polycyclic compounds
id: CHEBI:33635
in subset: 3 STAR

bicyclic compound
type: Class
subclass of: cyclic compound
definition: A molecule that features two fused rings.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: bicyclic compounds
id: CHEBI:33636
in subset: 3 STAR

aromatic compound
type: Class
subclass of: cyclic compound
definition: A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.
imported from: chebi.owl
has exact synonym: aromatic compounds
has exact synonym: aromatic molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: aromatics
has_related_synonym: aromatische Verbindungen
id: CHEBI:33655
in subset: 3 STAR

organic aromatic compound
type: Class
subclass of: aromatic compound
subclass of: organic cyclic compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic aromatic compounds
id: CHEBI:33659
in subset: 3 STAR

monocyclic compound
type: Class
subclass of: cyclic compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: monocyclic compounds
id: CHEBI:33661
in subset: 3 STAR

heteromonocyclic compound
type: Class
subclass of: monocyclic compound
subclass of: heterocyclic compound
imported from: chebi.owl
has exact synonym: heteromonocyclic compound
has exact synonym: heteromonocyclic compounds
has_obo_namespace: chebi_ontology
id: CHEBI:33670
in subset: 3 STAR

heteropolycyclic compound
type: Class
subclass of: polycyclic compound
subclass of: heterocyclic compound
definition: A polycyclic compound in which at least one of the rings contains at least one non-carbon atom.
imported from: chebi.owl
has exact synonym: heteropolycyclic compounds
has_obo_namespace: chebi_ontology
has_related_synonym: polyheterocyclic compounds
id: CHEBI:33671
in subset: 3 STAR

heterobicyclic compound
type: Class
subclass of: bicyclic compound
subclass of: heterocyclic compound
definition: A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom.
imported from: chebi.owl
has exact synonym: heterobicyclic compounds
has_obo_namespace: chebi_ontology
id: CHEBI:33672
in subset: 3 STAR

s-block molecular entity
type: Class
subclass of: main group molecular entity
definition: An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element.
imported from: chebi.owl
has exact synonym: s-block molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: s-block compounds
has_related_synonym: s-block molecular entities
id: CHEBI:33674
in subset: 3 STAR

p-block molecular entity
type: Class
subclass of: main group molecular entity
definition: A main group molecular entity that contains one or more atoms of a p-block element.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: p-block compounds
has_related_synonym: p-block molecular entities
has_related_synonym: p-block molecular entitiy
id: CHEBI:33675
in subset: 3 STAR

biomacromolecule
type: Class
subclass of: carbon group molecular entity
subclass of: macromolecule
definition: A macromolecule formed by a living organism.
imported from: chebi.owl
has exact synonym: biopolymer
has_obo_namespace: chebi_ontology
has_related_synonym: Biopolymere
has_related_synonym: biomacromolecules
has_related_synonym: biopolymers
id: CHEBI:33694
in subset: 3 STAR

information biomacromolecule
type: Class
subclass of: biomacromolecule
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: genetically encoded biomacromolecules
has_related_synonym: genetically encoded biopolymers
has_related_synonym: information biomacromolecules
has_related_synonym: information biopolymers
has_related_synonym: information macromolecule
has_related_synonym: information macromolecules
id: CHEBI:33695
in subset: 3 STAR

ribonucleic acid
type: Class
subclass of: pnictogen molecular entity
subclass of: information biomacromolecule
definition: High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins.
imported from: chebi.owl
database cross reference: CAS:63231-63-0
has exact synonym: ribonucleic acid
has exact synonym: ribonucleic acids
has_obo_namespace: chebi_ontology
has_related_synonym: RNA
has_related_synonym: RNS
has_related_synonym: Ribonukleinsaeure
has_related_synonym: pentosenucleic acids
has_related_synonym: ribonucleic acids
has_related_synonym: ribose nucleic acid
has_related_synonym: yeast nucleic acid
id: CHEBI:33697
in subset: 3 STAR

captopril
type: Class
subclass of: organosulfur compound
subclass of: organonitrogen compound
definition: A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.
imported from: chebi.owl
charge: 0
formula: C9H15NO3S
inchi: InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
inchikey: FAKRSMQSSFJEIM-RQJHMYQMSA-N
mass: 217.28500
monoisotopicmass: 217.07726
smiles: C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
database cross reference: Beilstein:477887
database cross reference: CAS:62571-86-2
database cross reference: DrugBank:DB01197
database cross reference: Drug_Central:484
database cross reference: KEGG:D00251
database cross reference: LINCS:LSM-5648
database cross reference: PMID:23137627
database cross reference: PMID:23161035
database cross reference: PMID:23278692
database cross reference: PMID:23299024
database cross reference: PMID:23328620
database cross reference: PMID:23397376
database cross reference: PMID:23410042
database cross reference: PMID:23422724
database cross reference: PMID:23429803
database cross reference: PMID:23435971
database cross reference: PMID:2420897
database cross reference: Patent:US4046889
database cross reference: Patent:US4105776
database cross reference: Wikipedia:Captopril
has exact synonym: 1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
has_obo_namespace: chebi_ontology
has_related_synonym: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
has_related_synonym: Acepress
has_related_synonym: Apopril
has_related_synonym: CP
has_related_synonym: Capoten
has_related_synonym: Captolane
has_related_synonym: Captopryl
has_related_synonym: Captoril
has_related_synonym: Cesplon
has_related_synonym: D-2-methyl-3-mercaptopropanoyl-L-proline
has_related_synonym: D-3-mercapto-2-methylpropanoyl-L-proline
has_related_synonym: Dilabar
has_related_synonym: Garranil
has_related_synonym: Hypertil
has_related_synonym: L-Captopril
has_related_synonym: Lopirin
has_related_synonym: Tenosbon
has_related_synonym: TensoboInOwln
has_related_synonym: Tensoprel
has_related_synonym: captopril
has_related_synonym: captoprilum
id: CHEBI:3380
in subset: 3 STAR

organic hydroxy compound
type: Class
subclass of: hydroxides
subclass of: chalcogen molecular entity
subclass of: carbon group molecular entity
subclass of: polyatomic entity
subclass of: organic molecular entity
definition: An organic compound having at least one hydroxy group attached to a carbon atom.
imported from: chebi.owl
has_alternative_id: CHEBI:64710
has exact synonym: hydroxy compounds
has_obo_namespace: chebi_ontology
has_related_synonym: organic alcohol
has_related_synonym: organic hydroxy compounds
id: CHEBI:33822
in subset: 3 STAR

organic cyclic compound
type: Class
subclass of: cyclic compound
subclass of: organic molecule
definition: Any organic molecule that consists of atoms connected in the form of a ring.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic cyclic compounds
id: CHEBI:33832
in subset: 3 STAR

heteroarene
type: Class
subclass of: organic heterocyclic compound
subclass of: organic aromatic compound
definition: A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).
imported from: chebi.owl
has exact synonym: heteroarenes
has_obo_namespace: chebi_ontology
has_related_synonym: hetarenes
id: CHEBI:33833
in subset: 3 STAR

benzenoid aromatic compound
type: Class
subclass of: carbocyclic compound
subclass of: organic aromatic compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: benzenoid aromatic compounds
has_related_synonym: benzenoid compound
id: CHEBI:33836
in subset: 3 STAR

macromolecule
type: Class
subclass of: polyatomic entity
definition: A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
imported from: chebi.owl
database cross reference: Wikipedia:Macromolecule
has exact synonym: macromolecule
has_obo_namespace: chebi_ontology
has_related_synonym: macromolecules
has_related_synonym: polymer
has_related_synonym: polymer molecule
has_related_synonym: polymers
id: CHEBI:33839
in subset: 3 STAR

phenols
type: Class
subclass of: organic aromatic compound
subclass of: organic hydroxy compound
definition: Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
imported from: chebi.owl
charge: 0
formula: C6HOR5
mass: 89.072
monoisotopicmass: 89.00274
smiles: C1(=C(C(=C(C(=C1*)*)*)*)*)O
has_alternative_id: CHEBI:13664
has_alternative_id: CHEBI:13825
has_alternative_id: CHEBI:25969
has_alternative_id: CHEBI:2857
database cross reference: KEGG:C15584
database cross reference: MetaCyc:Phenols
database cross reference: Wikipedia:Phenols
has exact synonym: phenols
has_obo_namespace: chebi_ontology
has_related_synonym: Aryl alcohol
has_related_synonym: a phenol
has_related_synonym: arenols
id: CHEBI:33853
in subset: 3 STAR

carbamazepine
type: Class
subclass of: central nervous system drug
definition: A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant.
imported from: chebi.owl
charge: 0
formula: C15H12N2O
inchi: InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
inchikey: FFGPTBGBLSHEPO-UHFFFAOYSA-N
mass: 236.26860
monoisotopicmass: 236.09496
smiles: NC(=O)N1c2ccccc2C=Cc2ccccc12
has_alternative_id: CHEBI:115086
database cross reference: Beilstein:1246090
database cross reference: CAS:298-46-4
database cross reference: DrugBank:DB00564
database cross reference: Drug_Central:489
database cross reference: HMDB:HMDB0014704
database cross reference: KEGG:C06868
database cross reference: KEGG:D00252
database cross reference: LINCS:LSM-3610
database cross reference: PMID:10411478
database cross reference: PMID:11071486
database cross reference: PMID:11129121
database cross reference: PMID:11240598
database cross reference: PMID:11475584
database cross reference: PMID:11595204
database cross reference: PMID:11888243
database cross reference: PMID:11891095
database cross reference: PMID:12073283
database cross reference: PMID:12228880
database cross reference: PMID:12475188
database cross reference: PMID:12749779
database cross reference: PMID:12799799
database cross reference: PMID:12957643
database cross reference: PMID:14160216
database cross reference: PMID:14572037
database cross reference: PMID:14581052
database cross reference: PMID:14713026
database cross reference: PMID:14723323
database cross reference: PMID:15165631
database cross reference: PMID:15557493
database cross reference: PMID:15665743
database cross reference: PMID:15683742
database cross reference: PMID:15739418
database cross reference: PMID:15820347
database cross reference: PMID:15850602
database cross reference: PMID:16033627
database cross reference: PMID:16150575
database cross reference: PMID:16245817
database cross reference: PMID:16380297
database cross reference: PMID:16394456
database cross reference: PMID:16437428
database cross reference: PMID:16538175
database cross reference: PMID:16562645
database cross reference: PMID:16616830
database cross reference: PMID:16990009
database cross reference: PMID:17027750
database cross reference: PMID:17028629
database cross reference: PMID:17207414
database cross reference: PMID:17582711
database cross reference: PMID:17873967
database cross reference: PMID:17949959
database cross reference: PMID:18163657
database cross reference: PMID:18415623
database cross reference: PMID:18637155
database cross reference: PMID:18652684
database cross reference: PMID:18656520
database cross reference: PMID:18969759
database cross reference: PMID:19135617
database cross reference: PMID:19473818
database cross reference: PMID:19741433
database cross reference: PMID:19921623
database cross reference: PMID:22322005
database cross reference: PMID:27967303
database cross reference: PMID:7602118
database cross reference: Patent:US2004220187
database cross reference: Patent:US2007167446
database cross reference: Patent:US2011177136
database cross reference: Patent:US2011245283
database cross reference: Patent:US2948718

ergoloid mesylate
type: Class
subclass of: organosulfur compound
definition: A mixture of hydrogenated ergot alkaloids consisting of the methanesulfonic acid salts of dihydroergocornine (R = CHMe2), dihydroergocristine (R = CH2Ph), and alpha- and beta-dihydroergocryptine (R = CH2CHMe2 and CH(Me)Et, respectively). It is used for the symptomatic treatment of mild to moderate dementia in the elderly, although its value is not established.
imported from: chebi.owl
charge: 0
formula: C29H38N5O8SR
mass: 616.708
monoisotopicmass: 616.24411
database cross reference: Beilstein:8896265
database cross reference: CAS:8067-24-1
database cross reference: DrugBank:DB01049
database cross reference: KEGG:C14055
database cross reference: KEGG:D02268
has_obo_namespace: chebi_ontology
has_related_synonym: Dihydroergotoxine mesilate
has_related_synonym: Dihydroergotoxine mesylate
has_related_synonym: Ergoloid mesylates
has_related_synonym: co-dergocrine mesilate
has_related_synonym: co-dergocrine mesylate
has_related_synonym: co-dergocrine methanesulfonate
has_related_synonym: codergocrine mesilate
has_related_synonym: codergocrine mesylate
has_related_synonym: codergocrine methanesulfonate
has_related_synonym: dihydroergotoxine methanesulfonate
has_related_synonym: dihydroergotoxine methanesulfonates
has_related_synonym: dihydroergotoxine monomethanesulfonate
has_related_synonym: dihydrogenated ergot alkaloids
has_related_synonym: ergoloid mesylates
has_related_synonym: ergoloid methanesulfonate
has_related_synonym: ergoloid methanesulfonates
has_related_synonym: hydrogenated ergot alkaloids
id: CHEBI:34706
in subset: 3 STAR

aldose phosphate
type: Class
subclass of: phospho sugar
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: aldose phosphates
id: CHEBI:35131
in subset: 3 STAR

inhibitor
type: Class
subclass of: biological role
definition: A substance that diminishes the rate of a chemical reaction.
imported from: chebi.owl
has exact synonym: inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: inhibidor
has_related_synonym: inhibiteur
has_related_synonym: inhibitors
id: CHEBI:35222
in subset: 3 STAR

organonitrogen compound
type: Class
subclass of: heteroorganic entity
subclass of: pnictogen molecular entity
subclass of: carbon group molecular entity
subclass of: nitrogen molecular entity
definition: Any heteroorganic entity containing at least one carbon-nitrogen bond.
imported from: chebi.owl
has exact synonym: organonitrogen compounds
has_obo_namespace: chebi_ontology
has_related_synonym: organonitrogens
id: CHEBI:35352
in subset: 3 STAR

sulfonamide
type: Class
subclass of: organosulfur compound
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
definition: An amide of a sulfonic acid RS(=O)2NR'2.
imported from: chebi.owl
charge: 0
formula: NO2SR3
mass: 78.07100
monoisotopicmass: 77.96497
smiles: [*]S(=O)(=O)N([*])[*]
database cross reference: PMID:11498380
database cross reference: PMID:2434548
database cross reference: PMID:26811268
database cross reference: PMID:26832216
database cross reference: Wikipedia:Sulfonamide
has exact synonym: sulfonamides
has_obo_namespace: chebi_ontology
has_related_synonym: sulfonamides
id: CHEBI:35358
in subset: 3 STAR

fatty acid
type: Class
subclass of: lipid
definition: Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax.
imported from: chebi.owl
charge: 0
formula: CHO2R
mass: 45.01740
monoisotopicmass: 44.99765
smiles: OC([*])=O
has_alternative_id: CHEBI:13633
has_alternative_id: CHEBI:24024
has_alternative_id: CHEBI:4984
database cross reference: KEGG:C00162
database cross reference: PMID:14287444
database cross reference: PMID:14300208
database cross reference: PMID:14328676
database cross reference: Wikipedia:Fatty_acid
has exact synonym: Fatty acid
has exact synonym: fatty acids
has_obo_namespace: chebi_ontology
has_related_synonym: Fettsaeure
has_related_synonym: Fettsaeuren
has_related_synonym: acide gras
has_related_synonym: acides gras
has_related_synonym: acido graso
has_related_synonym: acidos grasos
has_related_synonym: fatty acids
id: CHEBI:35366
in subset: 3 STAR

antidepressant
type: Class
subclass of: central nervous system drug
definition: Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: antidepressant drugs
has_related_synonym: antidepressants
has_related_synonym: thymoanaleptics
has_related_synonym: thymoleptic drugs
has_related_synonym: thymoleptics
id: CHEBI:35469
in subset: 3 STAR

central nervous system drug
type: Class
subclass of: drug
subclass of: Restriction
  on property: isTreatmentFor
  some values from: Alzheimer's disease
definition: A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: CNS agent
has_related_synonym: CNS drugs
has_related_synonym: central nervous system agents
id: CHEBI:35470
in subset: 3 STAR

psychotropic drug
type: Class
subclass of: central nervous system drug
definition: A loosely defined grouping of drugs that have effects on psychological function.
imported from: chebi.owl
database cross reference: Wikipedia:Psychotropic_drug
has_obo_namespace: chebi_ontology
has_related_synonym: psychoactive agent
has_related_synonym: psychoactive drugs
has_related_synonym: psychopharmaceuticals
has_related_synonym: psychotropic drugs
id: CHEBI:35471
in subset: 3 STAR

anti-inflammatory drug
type: Class
subclass of: drug
subclass of: anti-inflammatory agent
definition: A substance that reduces or suppresses inflammation.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-inflammatory drugs
has_related_synonym: antiinflammatory agent
has_related_synonym: antiinflammatory drug
has_related_synonym: antiinflammatory drugs
id: CHEBI:35472
in subset: 3 STAR

anxiolytic drug
type: Class
subclass of: central nervous system drug
definition: Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-anxiety agents
has_related_synonym: anti-anxiety drugs
has_related_synonym: anxiolytic agents
has_related_synonym: anxiolytics
has_related_synonym: minor tranquilisers
has_related_synonym: minor tranquilizers
has_related_synonym: minor tranquilizing agents
id: CHEBI:35474
in subset: 3 STAR

non-steroidal anti-inflammatory drug
type: Class
subclass of: application
definition: An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
imported from: chebi.owl
database cross reference: Wikipedia:Non-steroidal_anti-inflammatory_drug
has_obo_namespace: chebi_ontology
has_related_synonym: NSAID
has_related_synonym: NSAIDs
has_related_synonym: non-steroidal anti-inflammatory agent
has_related_synonym: non-steroidal anti-inflammatory drugs
id: CHEBI:35475
in subset: 3 STAR

antipsychotic agent
type: Class
subclass of: central nervous system drug
definition: Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Neuroleptikum
has_related_synonym: antipsychotic agents
has_related_synonym: antipsychotic drug
has_related_synonym: antipsychotic drugs
has_related_synonym: antipsychotics
has_related_synonym: antipsychotiques
has_related_synonym: grosser Tranquilizer
has_related_synonym: major tranquilizers
has_related_synonym: major tranquilizing agents
has_related_synonym: neuroleptic
has_related_synonym: neuroleptic agents
has_related_synonym: neuroleptics
has_related_synonym: neuroleptique
has_related_synonym: neuroleptiques
id: CHEBI:35476
in subset: 3 STAR

cerivastatin
type: Class
subclass of: organic hydroxy compound
subclass of: statin
definition: (3R,5S)-3,5-dihydroxyhept-6-enoic acid in which the (7E)-hydrogen is substituted by a 4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl group. Formerly used (as its sodium salt) to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.
imported from: chebi.owl
charge: 0
formula: C26H34FNO5
inchi: InChI=1S/C26H34FNO5/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32)/b11-10+/t19-,20-/m1/s1
inchikey: SEERZIQQUAZTOL-ANMDKAQQSA-N
mass: 459.55030
monoisotopicmass: 459.24210
has_alternative_id: CHEBI:503465
database cross reference: Beilstein:8366578
database cross reference: CAS:145599-86-6
database cross reference: DrugBank:DB00439
database cross reference: Drug_Central:577
database cross reference: KEGG:C07966
database cross reference: KEGG:D07661
database cross reference: PMID:17560788
database cross reference: PMID:18155906
database cross reference: Wikipedia:Cerivastatin
has exact synonym: (3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoic acid
has exact synonym: Cerivastatin
has_obo_namespace: chebi_ontology
has_related_synonym: (3R,5S,6E)-7-(4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl)-3,5-dihydroxy-6-heptenoic acid
has_related_synonym: (3R,5S,6E)-7-(4-(p-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl)-3,5-dihydroxy-6-heptenoic acid
has_related_synonym: (3R,5S,E)-7-(4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl)-3,5-dihydroxyhept-6-enoic acid
has_related_synonym: cerivastatin
has_related_synonym: cerivastatin acid
id: CHEBI:3558
in subset: 3 STAR

carbon oxoacid
type: Class
subclass of: oxoacid
subclass of: organooxygen compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: carbon oxoacids
has_related_synonym: oxoacids of carbon
id: CHEBI:35605
in subset: 3 STAR

cevimeline
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
charge: 0
formula: C10H17NOS
inchi: InChI=1S/C10H17NOS/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11/h8-9H,2-7H2,1H3/t8?,10-/m1/s1
inchikey: WUTYZMFRCNBCHQ-LHIURRSHSA-N
mass: 199.31412
monoisotopicmass: 199.10309
smiles: CC1O[C@@]2(CS1)CN1CCC2CC1
database cross reference: CAS:107233-08-9
database cross reference: DrugBank:DB00185
database cross reference: KEGG:D00661
database cross reference: KEGG:D07667
database cross reference: Wikipedia:Cevimeline
has exact synonym: (2R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane]
has exact synonym: (2R)-2'-methylspiro[4-quinuclidine -2,5'-[1,3]oxathiolane]
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Methyspiro(1,3-oxathiolane-5,3)quinuclidine
has_related_synonym: Sni 2011
has_related_synonym: cevimelina
has_related_synonym: cevimeline
has_related_synonym: cevimelinum
id: CHEBI:3568
in subset: 3 STAR

ester
type: Class
subclass of: carbon group molecular entity
subclass of: organooxygen compound
definition: A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.
imported from: chebi.owl
has_alternative_id: CHEBI:23960
has_alternative_id: CHEBI:4859
database cross reference: KEGG:C00287
database cross reference: Wikipedia:Ester
has exact synonym: Ester
has_obo_namespace: chebi_ontology
has_related_synonym: esters
id: CHEBI:35701
in subset: 3 STAR

glycerolipid
type: Class
subclass of: lipid
definition: Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached.
imported from: chebi.owl
database cross reference: PMID:18606873
has_obo_namespace: chebi_ontology
has_related_synonym: glycerolipids
id: CHEBI:35741
in subset: 3 STAR

sulfone
type: Class
subclass of: organosulfur compound
definition: An organosulfur compound having the structure RS(=O)2R (R =/= H).
imported from: chebi.owl
has exact synonym: sulfone
has_obo_namespace: chebi_ontology
has_related_synonym: sulfones
id: CHEBI:35850
in subset: 3 STAR

imidazopyrimidine
type: Class
subclass of: organic heterobicyclic compound
subclass of: heteroarene
subclass of: organonitrogen heterocyclic compound
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: imidazopyrimidines
id: CHEBI:35875
in subset: 3 STAR

docosahexaenoic acid
type: Class
subclass of: fatty acid
definition: Any C22 polyunsaturated fatty acid containing six double bonds.
imported from: chebi.owl
charge: 0
formula: C22H32O2
mass: 328.489
monoisotopicmass: 328.24023
has exact synonym: docosahexaenoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: DHA
has_related_synonym: docosahexaenoic acids
id: CHEBI:36005
in subset: 3 STAR

omega-6 fatty acid
type: Class
subclass of: fatty acid
definition: A family of polyunsaturated fatty acids that have in common a final carbon-carbon double bond in the n-6 position, i.e., the sixth bond from the methyl end of the fatty acid.
imported from: chebi.owl
database cross reference: PMID:19035453
database cross reference: PMID:19136835
has exact synonym: omega-6 fatty acid
has_obo_namespace: chebi_ontology
has_related_synonym: omega-6 fatty acids
id: CHEBI:36009
in subset: 3 STAR

protein
type: Class
subclass of: biomacromolecule
definition: A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome.
imported from: chebi.owl
has_alternative_id: CHEBI:13677
has_alternative_id: CHEBI:14911
has exact synonym: proteins
has_obo_namespace: chebi_ontology
id: CHEBI:36080
in subset: 3 STAR

glycerophosphoinositol
type: Class
subclass of: glycerophospholipid
definition: Any glycerophospholipid having the polar alcohol inositol esterified to the phosphate group at the sn-3 position of the glycerol backbone.
imported from: chebi.owl
has_alternative_id: CHEBI:26040
has_alternative_id: CHEBI:35770
database cross reference: PMID:14706866
has_obo_namespace: chebi_ontology
has_related_synonym: GPI
has_related_synonym: glycerophosphoinositols
id: CHEBI:36315
in subset: 3 STAR

polyatomic entity
type: Class
subclass of: molecular entity
subclass of: chemical entity
definition: Any molecular entity consisting of more than one atom.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: polyatomic entities
id: CHEBI:36357
in subset: 3 STAR

phosphorus oxoacid derivative
type: Class
subclass of: oxoacid derivative
subclass of: phosphorus oxoacids and derivatives
imported from: chebi.owl
has exact synonym: phosphorus oxoacid derivative
has_obo_namespace: chebi_ontology
id: CHEBI:36359
in subset: 3 STAR

phosphorus oxoacids and derivatives
type: Class
subclass of: phosphorus molecular entity
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:36360
in subset: 1 STAR

chlorpromazine
type: Class
subclass of: organohalogen compound
subclass of: organonitrogen compound
subclass of: phenothiazines
definition: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
imported from: chebi.owl
charge: 0
formula: C17H19ClN2S
inchi: InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
inchikey: ZPEIMTDSQAKGNT-UHFFFAOYSA-N
mass: 318.86400
monoisotopicmass: 318.09575
smiles: CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
database cross reference: Beilstein:289793
database cross reference: CAS:50-53-3
database cross reference: DrugBank:DB00477
database cross reference: Drug_Central:621
database cross reference: HMDB:HMDB0014620
database cross reference: KEGG:C06906
database cross reference: KEGG:D00270
database cross reference: LINCS:LSM-4017
database cross reference: PDBeChem:Z80
database cross reference: PMID:14354584
database cross reference: PMID:14404586
database cross reference: PMID:15170372
database cross reference: PMID:1650428
database cross reference: PMID:16653219
database cross reference: PMID:20825390
database cross reference: PMID:2427628
database cross reference: PMID:7192992
database cross reference: Patent:US2645640
database cross reference: Reaxys:289793
database cross reference: Wikipedia:Chlorpromazine
has exact synonym: 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
has exact synonym: Chlorpromazine
has_obo_namespace: chebi_ontology
has_related_synonym: 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine
has_related_synonym: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
has_related_synonym: Aminazine
has_related_synonym: CPZ
has_related_synonym: Chlorderazin
has_related_synonym: Chloropromazine
has_related_synonym: Chlorpromados
has_related_synonym: Contomin
has_related_synonym: Largactil
has_related_synonym: N-(3-dimethylaminopropyl)-3-chlorophenothiazine
has_related_synonym: Thorazine
has_related_synonym: chlorpromazine
has_related_synonym: chlorpromazinum
has_related_synonym: clorpromazina
id: CHEBI:3647
in subset: 3 STAR

chlorprothixene
type: Class
subclass of: organonitrogen compound
imported from: chebi.owl
charge: 0
formula: C18H18ClNS
inchi: InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3
inchikey: WSPOMRSOLSGNFJ-UHFFFAOYSA-N
mass: 315.86000
monoisotopicmass: 315.08485
smiles: [H]C(CCN(C)C)=C1c2ccccc2Sc2ccc(Cl)cc12
database cross reference: Beilstein:89898
database cross reference: CAS:113-59-7
database cross reference: DrugBank:DB01239
database cross reference: KEGG:C07953
database cross reference: KEGG:D00790
database cross reference: LINCS:LSM-3310
database cross reference: Patent:GB829763
database cross reference: Patent:US3046283
has exact synonym: 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine
has exact synonym: Chlorprothixene
has_obo_namespace: chebi_ontology
has_related_synonym: Alpha-Chlorprothixene
has_related_synonym: Chlorprothixen
has_related_synonym: Chlorprothixine
has_related_synonym: Chlorprotixen
has_related_synonym: Chlorprotixene
has_related_synonym: Chlorprotixine
has_related_synonym: Chlothixen
has_related_synonym: chlorprothixene
has_related_synonym: chlorprothixenum
has_related_synonym: clorprotixeno
id: CHEBI:3651
in subset: 3 STAR

carbonyl compound
type: Class
subclass of: organic oxo compound
subclass of: organooxygen compound
definition: Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
imported from: chebi.owl
has exact synonym: carbonyl compounds
has_obo_namespace: chebi_ontology
id: CHEBI:36586
in subset: 3 STAR

organic oxo compound
type: Class
subclass of: organic molecule
definition: Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element.
imported from: chebi.owl
has exact synonym: oxo compounds
has_obo_namespace: chebi_ontology
has_related_synonym: organic oxo compounds
id: CHEBI:36587
in subset: 3 STAR

escitalopram
type: Class
subclass of: carbon group molecular entity
definition: A 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile that has S-configuration at the chiral centre. It is the active enantiomer of citalopram.
imported from: chebi.owl
charge: 0
formula: C20H21FN2O
inchi: InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1
inchikey: WSEQXVZVJXJVFP-FQEVSTJZSA-N
mass: 324.39202
monoisotopicmass: 324.16379
smiles: CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c1ccc(F)cc1
database cross reference: Beilstein:9001444
database cross reference: CAS:128196-01-0
database cross reference: DrugBank:DB01175
database cross reference: Drug_Central:1053
database cross reference: HMDB:HMDB0005028
database cross reference: KEGG:D07913
database cross reference: LINCS:LSM-3569
database cross reference: PMID:14501259
database cross reference: PMID:14594439
database cross reference: PMID:14708881
database cross reference: PMID:15200745
database cross reference: PMID:15609164
database cross reference: PMID:16266205
database cross reference: PMID:16421462
database cross reference: PMID:16937393
database cross reference: PMID:16953656
database cross reference: PMID:18789789
database cross reference: PMID:19710642
database cross reference: PMID:20825390
database cross reference: PMID:24172161
database cross reference: PMID:24176515
database cross reference: PMID:24289655
database cross reference: PMID:24424469
database cross reference: PMID:24469525
database cross reference: PMID:24528284
database cross reference: Wikipedia:Escitalopram
has exact synonym: (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
has_obo_namespace: chebi_ontology
has_related_synonym: (+)-citalopram
has_related_synonym: (S)-citalopram
has_related_synonym: Esertia
has_related_synonym: S(+)-citalopram
has_related_synonym: S-(+)-citalopram
has_related_synonym: escitalopram
has_related_synonym: escitalopramum
id: CHEBI:36791
in subset: 3 STAR

duloxetine
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
charge: 0
formula: C18H19NOS
inchi: InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3
inchikey: ZEUITGRIYCTCEM-UHFFFAOYSA-N
mass: 297.41560
monoisotopicmass: 297.11874
smiles: CNCCC(Oc1cccc2ccccc12)c1cccs1
database cross reference: Beilstein:8842375
database cross reference: CAS:116539-58-3
database cross reference: PMID:20825390
has exact synonym: N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine
has_obo_namespace: chebi_ontology
has_related_synonym: N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine
id: CHEBI:36796
in subset: 3 STAR

ring assembly
type: Class
subclass of: cyclic compound
definition: Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved.
imported from: chebi.owl
has exact synonym: ring assemblies
has exact synonym: ring assembly
has_obo_namespace: chebi_ontology
id: CHEBI:36820
in subset: 3 STAR

organochalcogen compound
type: Class
subclass of: heteroorganic entity
subclass of: chalcogen molecular entity
definition: An organochalcogen compound is a compound containing at least one carbon-chalcogen bond.
imported from: chebi.owl
has exact synonym: organochalcogen compound
has_obo_namespace: chebi_ontology
has_related_synonym: organochalcogen compounds
id: CHEBI:36962
in subset: 3 STAR

organooxygen compound
type: Class
subclass of: oxygen molecular entity
subclass of: organochalcogen compound
definition: An organochalcogen compound containing at least one carbon-oxygen bond.
imported from: chebi.owl
database cross reference: PMID:17586126
has exact synonym: organooxygen compound
has_obo_namespace: chebi_ontology
has_related_synonym: organooxygen compounds
id: CHEBI:36963
in subset: 3 STAR

nucleotide
type: Class
subclass of: nucleoside phosphate
definition: A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid.
imported from: chebi.owl
has_alternative_id: CHEBI:13215
has_alternative_id: CHEBI:13663
has_alternative_id: CHEBI:7656
database cross reference: KEGG:C00215
database cross reference: Wikipedia:Nucleotide
has exact synonym: Nucleotide
has_obo_namespace: chebi_ontology
has_related_synonym: nucleotides
id: CHEBI:36976
in subset: 3 STAR

cilazapril
type: Class
subclass of: organic molecule
definition: A pyridazinodiazepine resulting from the formal condensation of the carboxy group of cilazaprilat with ethanol. It is a drug used in the treatment of hypertension and heart failure.
imported from: chebi.owl
charge: 0
formula: C22H31N3O5
inchi: InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1
inchikey: HHHKFGXWKKUNCY-FHWLQOOXSA-N
mass: 417.506
monoisotopicmass: 417.22637
database cross reference: CAS:88768-40-5
database cross reference: DrugBank:DB01340
database cross reference: Drug_Central:641
database cross reference: HMDB:HMDB0015433
database cross reference: KEGG:D07699
database cross reference: PMID:18297254
database cross reference: PMID:1836986
database cross reference: PMID:21760854
database cross reference: PMID:24383331
database cross reference: PMID:24754013
database cross reference: PMID:25272892
database cross reference: PMID:28334985
database cross reference: PMID:28445944
database cross reference: PMID:31531043
database cross reference: Wikipedia:Cilazapril
has exact synonym: (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
has_obo_namespace: chebi_ontology
has_related_synonym: Cilazapril anhydrous
has_related_synonym: Dynorm
has_related_synonym: Inhibace
has_related_synonym: Ro 34-2848
has_related_synonym: Vascace
has_related_synonym: Vascase
has_related_synonym: cilazapril
has_related_synonym: cilazaprilum
id: CHEBI:3698
in subset: 3 STAR

nucleoside bisphosphate
type: Class
subclass of: nucleoside phosphate
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: nucleoside bisphosphates
id: CHEBI:37123
in subset: 3 STAR

organofluorine compound
type: Class
subclass of: organohalogen compound
subclass of: fluorine molecular entity
definition: An organofluorine compound is a compound containing at least one carbon-fluorine bond.
imported from: chebi.owl
charge: 0
formula: FR
mass: 18.998
monoisotopicmass: 18.99840
smiles: *F
database cross reference: MetaCyc:Fluorides
has exact synonym: organofluorine compound
has_obo_namespace: chebi_ontology
has_related_synonym: fluoroorganic compound
has_related_synonym: fluoroorganic compounds
has_related_synonym: fluoroorganics
has_related_synonym: fluororganische Verbindungen
has_related_synonym: organofluorine compounds
id: CHEBI:37143
in subset: 3 STAR

organic hydride
type: Class
subclass of: polyatomic entity
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic hydrides
id: CHEBI:37175
in subset: 3 STAR

citalopram
type: Class
subclass of: antidepressant
definition: A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
imported from: chebi.owl
charge: 0
formula: C20H21FN2O
mass: 324.393
monoisotopicmass: 324.16379
database cross reference: Beilstein:1397373
database cross reference: CAS:59729-33-8
database cross reference: DrugBank:DB00215
database cross reference: HMDB:HMDB0005038
database cross reference: KEGG:C07572
database cross reference: KEGG:D07704
database cross reference: PMID:11336616
database cross reference: PMID:18213744
database cross reference: PMID:18219053
database cross reference: PMID:19747949
database cross reference: PMID:20825390
database cross reference: Patent:DE2657013
database cross reference: Patent:EP0171943
database cross reference: Patent:EP1506963
database cross reference: Patent:US4136193
database cross reference: Reaxys:1397373
database cross reference: Wikipedia:Citalopram
has exact synonym: Citalopram
has exact synonym: rac-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile
has_obo_namespace: chebi_ontology
has_related_synonym: 1,3-dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-5-isobenzofurancarbonitrile
has_related_synonym: 1-(3-(dimethylamino)propyl)-1-(p-fluorophenyl)-5-phthalancarbonitrile
has_related_synonym: Cipram
has_related_synonym: Citadur
has_related_synonym: Lu 10-171
has_related_synonym: Nitalapram
has_related_synonym: citalopram
has_related_synonym: citalopramum
id: CHEBI:3723
in subset: 3 STAR

adenosine 3',5'-bisphosphate
type: Class
subclass of: adenosine bisphosphate
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: adenosine 3',5'-bisphosphates
id: CHEBI:37240
in subset: 3 STAR

fatty acyl-CoA
type: Class
subclass of: acyl-CoA
subclass of: fatty acid derivative
definition: An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any fatty acid.
imported from: chebi.owl
charge: 0
formula: C22H35N7O17P3SR
mass: 794.53600
monoisotopicmass: 794.10230
has_alternative_id: CHEBI:24025
has_alternative_id: CHEBI:4987
database cross reference: PMID:11524729
database cross reference: PMID:20442897
database cross reference: PMID:2079609
has_obo_namespace: chebi_ontology
has_related_synonym: Fatty acyl CoA
has_related_synonym: fatty acyl-coenzyme A
has_related_synonym: fatty acyl-coenzyme As
id: CHEBI:37554
in subset: 3 STAR

omega-carboxyacyl-CoA
type: Class
subclass of: acyl-CoA
definition: An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of any alpha,omega-dicarboxylic acid.
imported from: chebi.owl
has_alternative_id: CHEBI:10614
has_alternative_id: CHEBI:13782
has_alternative_id: CHEBI:25688
database cross reference: KEGG:C03188
has exact synonym: omega-Carboxyacyl-CoA
has exact synonym: omega-carboxyacyl-CoA
has_obo_namespace: chebi_ontology
id: CHEBI:37555
in subset: 3 STAR

clonazepam
type: Class
subclass of: organohalogen compound
definition: 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
imported from: chebi.owl
charge: 0
formula: C15H10ClN3O3
inchi: InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20)
inchikey: DGBIGWXXNGSACT-UHFFFAOYSA-N
mass: 315.71100
monoisotopicmass: 315.04107
smiles: [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1
has_alternative_id: CHEBI:102465
database cross reference: Beilstein:759557
database cross reference: CAS:1622-61-3
database cross reference: DrugBank:DB01068
database cross reference: Drug_Central:703
database cross reference: KEGG:D00280
database cross reference: PMID:10633040
database cross reference: PMID:12213069
database cross reference: PMID:12873507
database cross reference: Patent:US3116203
database cross reference: Patent:US3121076
database cross reference: Patent:US3335181
database cross reference: Wikipedia:Clonazepam
has exact synonym: 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
has exact synonym: CLONAZEPAM
has_obo_namespace: chebi_ontology
has_related_synonym: 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one
has_related_synonym: 5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one
has_related_synonym: 5-(2-chlorophenyl)-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one
has_related_synonym: 5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
has_related_synonym: clonazepam
has_related_synonym: clonazepamum
id: CHEBI:3756
in subset: 3 STAR

heteroatomic molecular entity
type: Class
subclass of: polyatomic entity
definition: A molecular entity consisting of two or more chemical elements.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: chemical compound
has_related_synonym: heteroatomic molecular entities
id: CHEBI:37577
in subset: 3 STAR

halide
type: Class
subclass of: halogen molecular entity
subclass of: heteroatomic molecular entity
definition: Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements.
imported from: chebi.owl
database cross reference: Wikipedia:Halide
has_obo_namespace: chebi_ontology
has_related_synonym: halides
id: CHEBI:37578
in subset: 3 STAR

gamma-lactone
type: Class
subclass of: lactone
definition: A lactone having a five-membered lactone ring.
imported from: chebi.owl
charge: 0
formula: C4H3O2R3
mass: 83.066
monoisotopicmass: 83.01330
smiles: O1C(C(C(C1=O)*)*)*
has_alternative_id: CHEBI:13194
has_alternative_id: CHEBI:18937
has_alternative_id: CHEBI:22971
has_alternative_id: CHEBI:541
database cross reference: PMID:18789684
has_obo_namespace: chebi_ontology
has_related_synonym: 1,4-Lactone
has_related_synonym: 1,4-lactones
has_related_synonym: a 1,4-lactone
has_related_synonym: butyrolactones
has_related_synonym: gamma-Laktone
has_related_synonym: gamma-lactona
has_related_synonym: gamma-lactonas
has_related_synonym: gamma-lactones
id: CHEBI:37581
in subset: 3 STAR

carboxamide
type: Class
subclass of: primary amide
subclass of: organonitrogen compound
subclass of: organooxygen compound
definition: An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom.
imported from: chebi.owl
charge: 0
formula: CNOR3
mass: 42.01680
monoisotopicmass: 41.99799
smiles: [*]C(=O)N([*])[*]
has_alternative_id: CHEBI:35354
has_alternative_id: CHEBI:35355
has exact synonym: carboxamides
has_obo_namespace: chebi_ontology
has_related_synonym: carboxamides
has_related_synonym: primary carboxamide
id: CHEBI:37622
in subset: 3 STAR

clozapine
type: Class
subclass of: antipsychotic agent
definition: A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia.
imported from: chebi.owl
charge: 0
formula: C18H19ClN4
inchi: InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
inchikey: QZUDBNBUXVUHMW-UHFFFAOYSA-N
mass: 326.824
monoisotopicmass: 326.12982
database cross reference: Beilstein:0764984
database cross reference: CAS:5786-21-0
database cross reference: DrugBank:DB00363
database cross reference: Drug_Central:722
database cross reference: HMDB:HMDB0014507
database cross reference: KEGG:C06924
database cross reference: KEGG:D00283
database cross reference: PMID:18690109
database cross reference: PMID:18766167
database cross reference: PMID:20825390
database cross reference: PMID:24219174
database cross reference: Patent:FR1334944
database cross reference: Patent:NL293201
database cross reference: Patent:US3539573
database cross reference: Reaxys:764984
database cross reference: Wikipedia:Clozapine
has exact synonym: 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
has exact synonym: Clozapine
has_obo_namespace: chebi_ontology
has_related_synonym: Clozapin
has_related_synonym: clozapina
has_related_synonym: clozapine
has_related_synonym: clozapinum
id: CHEBI:3766
in subset: 3 STAR

phosphoric ester
type: Class
subclass of: phosphoric acid derivative
subclass of: ester
imported from: chebi.owl
has_alternative_id: CHEBI:26019
has_obo_namespace: chebi_ontology
id: CHEBI:37734
in subset: 1 STAR

glycerophospholipid
type: Class
subclass of: phospholipid
subclass of: glycerolipid
definition: Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone.
imported from: chebi.owl
has_alternative_id: CHEBI:24362
has_alternative_id: CHEBI:5456
database cross reference: PMID:17393491
has_obo_namespace: chebi_ontology
has_related_synonym: glycerophospholipids
has_related_synonym: phosphatide
has_related_synonym: phosphatides
has_related_synonym: phosphoglyceride
has_related_synonym: phosphoglycerides
id: CHEBI:37739
in subset: 3 STAR

phenothiazines
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:38093
in subset: 3 STAR

organonitrogen heterocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: organonitrogen compound
definition: Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: heterocyclic organonitrogen compounds
has_related_synonym: organonitrogen heterocyclic compounds
id: CHEBI:38101
in subset: 3 STAR

oxacycle
type: Class
subclass of: organic heterocyclic compound
subclass of: organooxygen compound
definition: Any organic heterocyclic compound containing at least one ring oxygen atom.
imported from: chebi.owl
database cross reference: PMID:17134300
has_obo_namespace: chebi_ontology
has_related_synonym: heterocyclic organooxygen compounds
has_related_synonym: organooxygen heterocyclic compounds
has_related_synonym: oxacycles
id: CHEBI:38104
in subset: 3 STAR

organic heteropolycyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: heteropolycyclic compound
imported from: chebi.owl
has_alternative_id: CHEBI:25429
has_alternative_id: CHEBI:38075
has_obo_namespace: chebi_ontology
has_related_synonym: organic heteropolycyclic compounds
id: CHEBI:38166
in subset: 3 STAR

EC 3.1.1.7 (acetylcholinesterase) inhibitor
type: Class
subclass of: enzyme inhibitor
definition: An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
imported from: chebi.owl
database cross reference: Wikipedia:Acetylcholinesterase_inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: AChEI
has_related_synonym: AcCholE inhibitor
has_related_synonym: AcCholE inhibitors
has_related_synonym: EC 3.1.1.7 (acetylcholinesterase) inhibitors
has_related_synonym: EC 3.1.1.7 inhibitor
has_related_synonym: EC 3.1.1.7 inhibitors
has_related_synonym: acetyl.beta-methylcholinesterase inhibitor
has_related_synonym: acetyl.beta-methylcholinesterase inhibitors
has_related_synonym: acetylcholine acetylhydrolase inhibitor
has_related_synonym: acetylcholine acetylhydrolase inhibitors
has_related_synonym: acetylcholine esterase inhibitor
has_related_synonym: acetylcholine hydrolase inhibitor
has_related_synonym: acetylcholine hydrolase inhibitors
has_related_synonym: acetylcholinesterase (EC 3.1.1.7) inhibitor
has_related_synonym: acetylcholinesterase (EC 3.1.1.7) inhibitors
has_related_synonym: acetylcholinesterase inhibitor
has_related_synonym: acetylcholinesterase inhibitors
has_related_synonym: acetylthiocholinesterase inhibitor
has_related_synonym: acetylthiocholinesterase inhibitors
has_related_synonym: choline esterase I inhibitor
has_related_synonym: choline esterase I inhibitors
has_related_synonym: cholinesterase inhibitor
has_related_synonym: cholinesterase inhibitors
has_related_synonym: true cholinesterase inhibitor
has_related_synonym: true cholinesterase inhibitors
id: CHEBI:38462
in subset: 3 STAR

rosuvastatin
type: Class
subclass of: organohalogen compound
subclass of: organosulfur compound
subclass of: organic hydroxy compound
subclass of: statin
definition: A dihydroxy monocarboxylic acid that is (6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl} hept-6-enoic acid carrying two hydroxy substituents at positions 3 and 5 (the 3R,5S-diastereomer).
imported from: chebi.owl
charge: 0
formula: C22H28FN3O6S
inchi: InChI=1S/C22H28FN3O6S/c1-13(2)20-18(10-9-16(27)11-17(28)12-19(29)30)21(14-5-7-15(23)8-6-14)25-22(24-20)26(3)33(4,31)32/h5-10,13,16-17,27-28H,11-12H2,1-4H3,(H,29,30)/b10-9+/t16-,17-/m1/s1
inchikey: BPRHUIZQVSMCRT-VEUZHWNKSA-N
mass: 481.53800
monoisotopicmass: 481.16828
database cross reference: Beilstein:9670765
database cross reference: CAS:287714-41-4
database cross reference: DrugBank:DB01098
database cross reference: Drug_Central:2406
database cross reference: HMDB:HMDB0015230
database cross reference: KEGG:D08492
database cross reference: PMID:17970755
database cross reference: PMID:18509206
database cross reference: PMID:19724024
database cross reference: PMID:19956889
database cross reference: PMID:23806820
database cross reference: PMID:23881596
database cross reference: PMID:23944632
database cross reference: PMID:24072337
database cross reference: PMID:24076283
database cross reference: PMID:24076297
database cross reference: PMID:24156555
database cross reference: PMID:24163149
database cross reference: PMID:24230979
database cross reference: PMID:24253250
database cross reference: PMID:24259612
database cross reference: PMID:24304551
database cross reference: PMID:24333476
database cross reference: PMID:24353409
database cross reference: PMID:24410968
database cross reference: PMID:24417785
database cross reference: PMID:24434545
database cross reference: PMID:24440231
database cross reference: PMID:24440960
database cross reference: PMID:24444439
database cross reference: PMID:24452083
database cross reference: PMID:24456217
database cross reference: PMID:24467235
database cross reference: Patent:US2013035316
database cross reference: Reaxys:9670765
database cross reference: Wikipedia:Rosuvastatin
has exact synonym: (3R,5S,6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (3R,5S,6E)-7-(4-(4-fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid
has_related_synonym: (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
has_related_synonym: rosuvastatin
id: CHEBI:38545
in subset: 3 STAR

fluvastatin
type: Class
subclass of: racemate
subclass of: statin
definition: A racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. An HMG-CoA reductase inhibitor, it is used (often as the corresponding sodium salt) to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia.
imported from: chebi.owl
charge: 0
formula: C24H26FNO4
inchi: InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m0/s1
inchikey: FJLGEFLZQAZZCD-JUFISIKESA-N
mass: 411.467
monoisotopicmass: 411.18459
database cross reference: Beilstein:9168031
database cross reference: CAS:93957-54-1
database cross reference: DrugBank:DB01095
database cross reference: KEGG:C07014
database cross reference: KEGG:D07983
database cross reference: PMID:11273020
database cross reference: PMID:12147804
database cross reference: PMID:18410471
database cross reference: PMID:18413661
database cross reference: PMID:18452779
database cross reference: PMID:18936176
database cross reference: PMID:23212095
database cross reference: PMID:23846727
database cross reference: Patent:US4739073
database cross reference: Patent:WO8402131
database cross reference: Wikipedia:Fluvastatin
has exact synonym: rac-(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-fluvastatin
has_related_synonym: (6E)-erythro7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
has_related_synonym: Cranoc
has_related_synonym: erythro-(E)-3,5-dihydroxy-7-[3'-(4''-fluorophenyl)-1'-(1''-methylethyl)indol-2'-yl]hept-6-enoic acid
has_related_synonym: fluvastatin
has_related_synonym: fluvastatina
has_related_synonym: fluvastatine
has_related_synonym: fluvastatinum
has_related_synonym: rac-(3R,5S)-fluvastatin
has_related_synonym: rac-(3R,5S,6E)-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic acid
id: CHEBI:38561
in subset: 3 STAR

(R)-flurbiprofen
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
charge: 0
formula: C15H13FO2
inchi: InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1
inchikey: SYTBZMRGLBWNTM-SNVBAGLBSA-N
mass: 244.26092
monoisotopicmass: 244.08996
smiles: C[C@@H](C(O)=O)c1ccc(c(F)c1)-c1ccccc1
database cross reference: Beilstein:4686157
database cross reference: Beilstein:5745751
database cross reference: CAS:51543-40-9
has exact synonym: (2R)-2-(2-fluoro-[1,1'-biphenyl-4-yl])propanoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid
has_related_synonym: (2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid
has_related_synonym: (R)-2-fluoro-alpha-methyl(1,1'-biphenyl)-4-acetic acid
has_related_synonym: Flurizan
has_related_synonym: Tarenflurbil
id: CHEBI:38666
in subset: 3 STAR

fluorobiphenyl
type: Class
subclass of: organohalogen compound
subclass of: biphenyls
subclass of: organofluorine compound
subclass of: organic molecule
definition: Any member of the class of biphenyls that is a mono or poly-substituted biphenyl having fluro group as one of the substituents.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: fluorobiphenyls
id: CHEBI:38679
in subset: 3 STAR

anthocyanin
type: Class
subclass of: ion
definition: Any flavonoid that is a glycoside derivative of anthocyanidin. Anthocyanins are water-souluble plant pigments that generally occur as acidic salts exhibiting bright colours.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anthocyanins
id: CHEBI:38697
in subset: 3 STAR

low-density lipoprotein
type: Class
subclass of: protein
definition: A class of lipoproteins of small size (18-25 nm) and low density (1.019-1.063 g/ml) particles with a core composed mainly of cholesterol esters and smaller amounts of triglycerides. The surface monolayer consists mostly of phospholipids, a single copy of apolipoprotein B-100, and free cholesterol molecules. The main function of LDL is to transport cholesterol and cholesterol esters from the liver. Excessive levels are associated with cardiovascular disease.
imported from: chebi.owl
database cross reference: PMID:11082530
database cross reference: PMID:15583011
database cross reference: PMID:15913955
database cross reference: PMID:19349632
database cross reference: PMID:28401639
database cross reference: PMID:28432662
database cross reference: PMID:28792690
database cross reference: PMID:28827781
database cross reference: PMID:28847800
database cross reference: PMID:28859941
database cross reference: PMID:28870972
database cross reference: Wikipedia:Low-density_lipoprotein
has_obo_namespace: chebi_ontology
has_related_synonym: LDL
has_related_synonym: beta-lipoproteins
has_related_synonym: low-density lipoproteins
id: CHEBI:39026
in subset: 3 STAR

atorvastatin
type: Class
subclass of: organohalogen compound
subclass of: organic hydroxy compound
subclass of: organic molecule
subclass of: statin
definition: A dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases.
imported from: chebi.owl
charge: 0
formula: C33H35FN2O5
inchi: InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1
inchikey: XUKUURHRXDUEBC-KAYWLYCHSA-N
mass: 558.63988
monoisotopicmass: 558.25300
has_alternative_id: CHEBI:2910
has_alternative_id: CHEBI:39538
database cross reference: Beilstein:8373630
database cross reference: CAS:134523-00-5
database cross reference: DrugBank:DB01076
database cross reference: Drug_Central:257
database cross reference: HMDB:HMDB0005006
database cross reference: KEGG:C06834
database cross reference: KEGG:D07474
database cross reference: LINCS:LSM-5771
database cross reference: PDBeChem:117
database cross reference: PMID:11693468
database cross reference: PMID:15012735
database cross reference: PMID:18720283
database cross reference: Patent:EP409281
database cross reference: Patent:US5273995
database cross reference: Reaxys:8373630
database cross reference: Wikipedia:Atorvastatin
has exact synonym: (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-4-phenyl-2-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
has exact synonym: Atorvastatin
has_obo_namespace: chebi_ontology
has_related_synonym: (R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid
has_related_synonym: 7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID
has_related_synonym: Atorlip
has_related_synonym: atorvastatin
has_related_synonym: atorvastatina
has_related_synonym: atorvastatine
has_related_synonym: atorvastatinum
id: CHEBI:39548
in subset: 3 STAR

curcumin
type: Class
subclass of: ketone
subclass of: ether
subclass of: organic hydroxy compound
definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
imported from: chebi.owl
charge: 0
formula: C21H20O6
inchi: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
inchikey: VFLDPWHFBUODDF-FCXRPNKRSA-N
mass: 368.381
monoisotopicmass: 368.12599
smiles: C1(=CC(=C(O)C=C1)OC)/C=C/C(CC(/C=C/C2=CC(=C(O)C=C2)OC)=O)=O
database cross reference: CAS:458-37-7
database cross reference: HMDB:HMDB0002269
database cross reference: KEGG:C10443
database cross reference: KNApSAcK:C00002731
database cross reference: MetaCyc:CPD-6602
database cross reference: PMID:10923784
database cross reference: PMID:12083767
database cross reference: PMID:12826232
database cross reference: PMID:14561543
database cross reference: PMID:14634121
database cross reference: PMID:15129424
database cross reference: PMID:15659840
database cross reference: PMID:15753945
database cross reference: PMID:15809436
database cross reference: PMID:15842781
database cross reference: PMID:15879598
database cross reference: PMID:16276182
database cross reference: PMID:16292655
database cross reference: PMID:16972983
database cross reference: PMID:17182546
database cross reference: PMID:18815282
database cross reference: PMID:19038979
database cross reference: PMID:19204190
database cross reference: PMID:19234767
database cross reference: PMID:20057137
database cross reference: PMID:21466422
database cross reference: PMID:21642934
database cross reference: PMID:22044005
database cross reference: PMID:22051121
database cross reference: PMID:22118895
database cross reference: PMID:22122768
database cross reference: PMID:22211691
database cross reference: PMID:22318308
database cross reference: PMID:22753715
database cross reference: PMID:23386263
database cross reference: PMID:23574161
database cross reference: PMID:9698073
database cross reference: Patent:DE859145
database cross reference: Patent:KR20130050834
database cross reference: Reaxys:2306965
database cross reference: Wikipedia:Curcumin
has exact synonym: (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
has exact synonym: Curcumin
has exact synonym: curcumin
has_obo_namespace: chebi_ontology
has_related_synonym: C.I. 75300
has_related_synonym: C.I. Natural Yellow 3
has_related_synonym: Diferuloylmethane
has_related_synonym: E 100
has_related_synonym: Kacha haldi
has_related_synonym: Natural yellow 3
has_related_synonym: Turmeric yellow
id: CHEBI:3962
in subset: 3 STAR

lovastatin
type: Class
subclass of: organic molecule
subclass of: statin
definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
imported from: chebi.owl
charge: 0
formula: C24H36O5
inchi: InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1
inchikey: PCZOHLXUXFIOCF-BXMDZJJMSA-N
mass: 404.53964
monoisotopicmass: 404.25627
has_alternative_id: CHEBI:40299
has_alternative_id: CHEBI:6544
database cross reference: Beilstein:3631989
database cross reference: CAS:75330-75-5
database cross reference: DrugBank:DB00227
database cross reference: Drug_Central:1612
database cross reference: HMDB:HMDB0014372
database cross reference: KEGG:C07074
database cross reference: KEGG:D00359
database cross reference: KNApSAcK:C00000547
database cross reference: LINCS:LSM-2189
database cross reference: PDBeChem:803
database cross reference: PMID:11375168
database cross reference: PMID:11389707
database cross reference: PMID:11483865
database cross reference: PMID:18642339
database cross reference: PMID:24093797
database cross reference: PMID:7720768
database cross reference: Patent:CN103172602
database cross reference: Patent:WO2013090461
database cross reference: Reaxys:4720754
database cross reference: Wikipedia:Lovastatin
has exact synonym: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
has exact synonym: LOVASTATIN
has exact synonym: Lovastatin
has exact synonym: lovastatin
has_obo_namespace: chebi_ontology
has_related_synonym: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate
has_related_synonym: 2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone
has_related_synonym: 6alpha-methylcompactin
has_related_synonym: MK-803
has_related_synonym: ML-530B
has_related_synonym: Mevacor
has_related_synonym: Mevinolin
id: CHEBI:40303
in subset: 3 STAR

celecoxib
type: Class
subclass of: organohalogen compound
subclass of: organosulfur compound
definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
imported from: chebi.owl
charge: 0
formula: C17H14F3N3O2S
inchikey: RZEKVGVHFLEQIL-UHFFFAOYSA-N
mass: 381.37200
monoisotopicmass: 381.07588
smiles: Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
has_alternative_id: CHEBI:3520
has_alternative_id: CHEBI:41418
database cross reference: CAS:169590-42-5
database cross reference: CAS:184007-95-2
database cross reference: DrugBank:DB00482
database cross reference: Drug_Central:568
database cross reference: HMDB:HMDB0005014
database cross reference: KEGG:C07589
database cross reference: KEGG:D00567
database cross reference: LINCS:LSM-2032
database cross reference: PDBeChem:CEL
database cross reference: PMID:17983259
database cross reference: PMID:18405470
database cross reference: PMID:19137124
database cross reference: PMID:19203891
database cross reference: PMID:21955617
database cross reference: PMID:22141388
database cross reference: PMID:22419293
database cross reference: PMID:22971036
database cross reference: PMID:23296687
database cross reference: PMID:23506230
database cross reference: PMID:28166217
database cross reference: Reaxys:8280770
database cross reference: Wikipedia:Celecoxib
has exact synonym: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
has exact synonym: Celecoxib
has_obo_namespace: chebi_ontology
has_related_synonym: Celebrex
has_related_synonym: celecoxib
has_related_synonym: celecoxibum
has_related_synonym: p-(5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl)benzenesulfonamide
id: CHEBI:41423
in subset: 3 STAR

galanthamine
type: Class
subclass of: organonitrogen compound
definition: A benzazepine alkaloid isolated from certain species of daffodils.
imported from: chebi.owl
charge: 0
formula: C17H21NO3
inchi: InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
inchikey: ASUTZQLVASHGKV-JDFRZJQESA-N
mass: 287.35358
monoisotopicmass: 287.15214
has_alternative_id: CHEBI:42935
has_alternative_id: CHEBI:5264
database cross reference: Beilstein:93736
database cross reference: CAS:357-70-0
database cross reference: DrugBank:DB00674
database cross reference: Drug_Central:1272
database cross reference: KEGG:C08526
database cross reference: KEGG:D04292
database cross reference: KNApSAcK:C00001570
database cross reference: LINCS:LSM-5604
database cross reference: PDBeChem:GNT
database cross reference: PMID:11060814
database cross reference: PMID:11950787
database cross reference: PMID:12177686
database cross reference: PMID:14674789
database cross reference: PMID:15495017
database cross reference: PMID:15537482
database cross reference: PMID:16437436
database cross reference: PMID:19253410
database cross reference: PMID:19782102
database cross reference: PMID:5333582
database cross reference: Reaxys:93736
database cross reference: Wikipedia:Galantamine
has exact synonym: Galanthamine
has exact synonym: galanthamine
has_obo_namespace: chebi_ontology
has_related_synonym: (-)-GALANTHAMINE
has_related_synonym: Galantamine
id: CHEBI:42944
in subset: 3 STAR

dapsone
type: Class
subclass of: organosulfur compound
subclass of: organonitrogen compound
definition: A sulfone that is diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy.
imported from: chebi.owl
charge: 0
formula: C12H12N2O2S
inchi: InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
inchikey: MQJKPEGWNLWLTK-UHFFFAOYSA-N
mass: 248.30100
monoisotopicmass: 248.06195
smiles: Nc1ccc(cc1)S(=O)(=O)c1ccc(N)cc1
has_alternative_id: CHEBI:226356
database cross reference: Beilstein:788055
database cross reference: CAS:80-08-0
database cross reference: DrugBank:DB00250
database cross reference: Drug_Central:782
database cross reference: HMDB:HMDB0014395
database cross reference: KEGG:C07666
database cross reference: KEGG:D00592
database cross reference: LINCS:LSM-5714
database cross reference: PMID:16361748
database cross reference: PMID:18035772
database cross reference: PMID:24232126
database cross reference: PMID:24512442
database cross reference: PMID:28434260
database cross reference: PMID:28699887
database cross reference: PMID:28732451
database cross reference: PMID:29045131
database cross reference: PMID:29192974
database cross reference: PMID:29192999
database cross reference: PMID:29233746
database cross reference: PMID:29280553
database cross reference: Patent:FR829926
database cross reference: Reaxys:788055
database cross reference: Wikipedia:Dapsone
has exact synonym: 4,4'-sulfonyldianiline
has exact synonym: DAPSONE
has exact synonym: Dapsone
has_obo_namespace: chebi_ontology
has_related_synonym: 1,1'-sulfonylbis(4-aminobenzene)
has_related_synonym: 4,4'-Sulfonylbisbenzenamine
has_related_synonym: 4,4'-dapsone
has_related_synonym: 4,4'-diaminodiphenyl sulfone
has_related_synonym: 4,4'-sulfonylbisaniline
has_related_synonym: 4-(4-amino-benzenesulfonyl)-phenylamine
has_related_synonym: 4-(4-aminophenylsulfonyl)aniline
has_related_synonym: 4-(4-aminophenylsulfonyl)benzenamine
has_related_synonym: 4-aminophenyl sulfone
has_related_synonym: Bis(p-aminophenyl) sulfone
has_related_synonym: DADPS
has_related_synonym: DDS
has_related_synonym: DIAPHENYLSULFONE
has_related_synonym: Diaphenylsulfone
has_related_synonym: bis(4-aminophenyl)sulfone
has_related_synonym: dapsona
has_related_synonym: dapsone
has_related_synonym: dapsonum
has_related_synonym: p,p'-diaminodiphenyl sulfone
has_related_synonym: p,p-sulphonylbisbenzamine
has_related_synonym: p,p-sulphonylbisbenzenamine
has_related_synonym: p-aminophenyl sulfone
id: CHEBI:4325
in subset: 3 STAR

Decursin
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
charge: 0
formula: C19H20O5
inchi: InChI=1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
inchikey: CUKSFECWKQBVED-INIZCTEOSA-N
mass: 328.360
monoisotopicmass: 328.13107
database cross reference: CAS:5928-25-6
database cross reference: KEGG:C09258
database cross reference: KNApSAcK:C00002465
has exact synonym: Decursin
has_obo_namespace: chebi_ontology
id: CHEBI:4353
in subset: 2 STAR

lisinopril
type: Class
subclass of: organonitrogen compound
imported from: chebi.owl
charge: 0
formula: C21H31N3O5
inchi: InChI=1S/C21H31N3O5/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)/t16-,17-,18-/m0/s1
inchikey: RLAWWYSOJDYHDC-BZSNNMDCSA-N
mass: 405.48790
monoisotopicmass: 405.22637
has_alternative_id: CHEBI:43750
database cross reference: Beilstein:4276619
database cross reference: CAS:76547-98-3
database cross reference: DrugBank:DB00722
database cross reference: Drug_Central:1587
database cross reference: LINCS:LSM-5756
database cross reference: PDBeChem:LPR
database cross reference: Wikipedia:Lisinopril
has exact synonym: N(2)-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline
has_obo_namespace: chebi_ontology
has_related_synonym: (S)-1-(N(2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-L-proline
has_related_synonym: [N2-[(S)-1-CARBOXY-3-PHENYLPROPYL]-L-LYSYL-L-PROLINE
has_related_synonym: lisinopril anhydrous
id: CHEBI:43755
in subset: 3 STAR

trifluoperazine
type: Class
subclass of: organohalogen compound
subclass of: organonitrogen compound
subclass of: phenothiazines
definition: A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
imported from: chebi.owl
charge: 0
formula: C21H24F3N3S
inchi: InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3
inchikey: ZEWQUBUPAILYHI-UHFFFAOYSA-N
mass: 407.49669
monoisotopicmass: 407.16430
has_alternative_id: CHEBI:45949
has_alternative_id: CHEBI:9709
database cross reference: Beilstein:57272
database cross reference: CAS:117-89-5
database cross reference: DrugBank:DB00831
database cross reference: Drug_Central:2740
database cross reference: Gmelin:2415561
database cross reference: HMDB:HMDB0014969
database cross reference: KEGG:C07168
database cross reference: KEGG:D08636
database cross reference: LINCS:LSM-4010
database cross reference: PDBeChem:TFP
database cross reference: PMID:11121417
database cross reference: PMID:14974020
database cross reference: PMID:15722405
database cross reference: PMID:1650428
database cross reference: PMID:19277699
database cross reference: PMID:19747949
database cross reference: PMID:20544963
database cross reference: PMID:7404501
database cross reference: PMID:9730919
database cross reference: Reaxys:57272
database cross reference: Wikipedia:Trifluoperazine
has exact synonym: 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
has exact synonym: Trifluoperazine
has_obo_namespace: chebi_ontology
has_related_synonym: 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE
has_related_synonym: 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine
has_related_synonym: trifluoperazina
has_related_synonym: trifluoperazine
has_related_synonym: trifluoperazinum
has_related_synonym: trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine
has_related_synonym: trifluoroperazine
has_related_synonym: trifluperazine
id: CHEBI:45951
in subset: 3 STAR

tacrine
type: Class
subclass of: organonitrogen compound
definition: A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.
imported from: chebi.owl
charge: 0
formula: C13H14N2
inchi: InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
inchikey: YLJREFDVOIBQDA-UHFFFAOYSA-N
mass: 198.26374
monoisotopicmass: 198.11570
smiles: Nc1c2CCCCc2nc2ccccc12
has_alternative_id: CHEBI:45978
has_alternative_id: CHEBI:9389
database cross reference: Beilstein:147610
database cross reference: CAS:321-64-2
database cross reference: DrugBank:DB00382
database cross reference: Drug_Central:2551
database cross reference: KEGG:C01453
database cross reference: KEGG:D08555
database cross reference: LINCS:LSM-5871
database cross reference: PDBeChem:THA
database cross reference: PMID:10817586
database cross reference: PMID:24560791
database cross reference: PMID:7866482
database cross reference: Reaxys:147610
database cross reference: Wikipedia:Tacrine
has exact synonym: 1,2,3,4-tetrahydroacridin-9-amine
has exact synonym: TACRINE
has exact synonym: Tacrine
has_obo_namespace: chebi_ontology
has_related_synonym: 1,2,3,4-tetrahydro-9-acridinamine
has_related_synonym: 1,2,3,4-tetrahydro-9-aminoacridine
has_related_synonym: 5-amino-6,7,8,9-tetrahydroacridine
has_related_synonym: 9-amino-1,2,3,4-tetrahydroacridine
has_related_synonym: tetrahydroaminacrine
id: CHEBI:45980
in subset: 3 STAR

doxepin
type: Class
subclass of: organonitrogen compound
definition: A dibenzooxepine that is 6,11-dihydrodibenzo[b,e]oxepine substituted by a 3-(dimethylamino)propylidene group at position 11. It is used as an antidepressant drug.
imported from: chebi.owl
charge: 0
formula: C19H21NO
inchi: InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3
inchikey: ODQWQRRAPPTVAG-UHFFFAOYSA-N
mass: 279.37618
monoisotopicmass: 279.16231
smiles: [H]C(CCN(C)C)=C1c2ccccc2COc2ccccc12
database cross reference: Beilstein:1348849
database cross reference: CAS:1668-19-5
database cross reference: DrugBank:DB01142
database cross reference: Drug_Central:956
database cross reference: HMDB:HMDB0015273
database cross reference: KEGG:C06971
database cross reference: KEGG:D07875
database cross reference: LINCS:LSM-2803
database cross reference: PMID:15014590
database cross reference: PMID:19357442
database cross reference: Reaxys:1348849
database cross reference: Wikipedia:Doxepin
has exact synonym: 3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine
has exact synonym: Doxepin
has_obo_namespace: chebi_ontology
has_related_synonym: 3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine
id: CHEBI:4710
in subset: 3 STAR

droperidol
type: Class
subclass of: ketone
subclass of: organohalogen compound
definition: An organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon.
imported from: chebi.owl
charge: 0
formula: C22H22FN3O2
inchi: InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)
inchikey: RMEDXOLNCUSCGS-UHFFFAOYSA-N
mass: 379.42740
monoisotopicmass: 379.16961
has_alternative_id: CHEBI:252751
database cross reference: Beilstein:579168
database cross reference: CAS:548-73-2
database cross reference: DrugBank:DB00450
database cross reference: Drug_Central:966
database cross reference: KEGG:D00308
database cross reference: LINCS:LSM-4193
database cross reference: Patent:US3161645
database cross reference: Wikipedia:Droperidol
has exact synonym: 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
has_obo_namespace: chebi_ontology
has_related_synonym: 1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
has_related_synonym: 1-(1-(4-(p-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
has_related_synonym: 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one
has_related_synonym: 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one
has_related_synonym: droperidol
has_related_synonym: droperidolum
id: CHEBI:4717
in subset: 3 STAR

diclofenac
type: Class
subclass of: organohalogen compound
subclass of: organonitrogen compound
definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
imported from: chebi.owl
charge: 0
formula: C14H11Cl2NO2
inchi: InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
inchikey: DCOPUUMXTXDBNB-UHFFFAOYSA-N
mass: 296.150
monoisotopicmass: 295.01668
smiles: C1(Cl)=CC=CC(=C1NC2=CC=CC=C2CC(=O)O)Cl
has_alternative_id: CHEBI:4507
has_alternative_id: CHEBI:47380
database cross reference: Beilstein:2146636
database cross reference: CAS:15307-86-5
database cross reference: DrugBank:DB00586
database cross reference: Drug_Central:865
database cross reference: HMDB:HMDB0014724
database cross reference: KEGG:C01690
database cross reference: KEGG:D07816
database cross reference: LINCS:LSM-2160
database cross reference: PDBeChem:DIF
database cross reference: PMID:11322639
database cross reference: PMID:1502708
database cross reference: PMID:23777257
database cross reference: PMID:27967303
database cross reference: PMID:7838674
database cross reference: Patent:NL6604752
database cross reference: Patent:US3558690
database cross reference: Reaxys:2146636
database cross reference: VSDB:1933
database cross reference: Wikipedia:Diclofenac
has exact synonym: 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid
has exact synonym: Diclofenac
has exact synonym: {2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid
has_obo_namespace: chebi_ontology
has_related_synonym: 2-((2,6-dichlorophenyl)amino)benzeneacetic acid
has_related_synonym: [2-(2,6-dichloroanilino)phenyl]acetic acid
has_related_synonym: diclofenac
has_related_synonym: diclofenac acid
has_related_synonym: diclofenaco
has_related_synonym: diclofenacum
has_related_synonym: diclofenamic acid
id: CHEBI:47381
in subset: 3 STAR

imipramine
type: Class
subclass of: carbon group molecular entity
definition: A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
imported from: chebi.owl
charge: 0
formula: C19H24N2
inchi: InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3
inchikey: BCGWQEUPMDMJNV-UHFFFAOYSA-N
mass: 280.40734
monoisotopicmass: 280.19395
smiles: CN(C)CCCN1c2ccccc2CCc2ccccc12
has_alternative_id: CHEBI:47498
has_alternative_id: CHEBI:5881
database cross reference: Beilstein:256892
database cross reference: CAS:50-49-7
database cross reference: DrugBank:DB00458
database cross reference: Drug_Central:1427
database cross reference: Gmelin:1572523
database cross reference: HMDB:HMDB0001848
database cross reference: KEGG:C07049
database cross reference: KEGG:D08070
database cross reference: LINCS:LSM-2852
database cross reference: PDBeChem:IXX
database cross reference: PMID:20825390
database cross reference: Patent:US2554736
database cross reference: Reaxys:256892
database cross reference: Wikipedia:Imipramine
has exact synonym: 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
has exact synonym: Imipramine
has_obo_namespace: chebi_ontology
has_related_synonym: 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine
has_related_synonym: 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
has_related_synonym: 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine
has_related_synonym: Antideprin
has_related_synonym: Imipramin
has_related_synonym: Irmin
has_related_synonym: Melipramine
has_related_synonym: N-(gamma-dimethylaminopropyl)iminodibenzyl
has_related_synonym: imipramine
has_related_synonym: imipraminum
has_related_synonym: imizine
id: CHEBI:47499
in subset: 3 STAR

clomipramine
type: Class
subclass of: carbon group molecular entity
definition: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
imported from: chebi.owl
charge: 0
formula: C19H23ClN2
inchi: InChI=1S/C19H23ClN2/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3
inchikey: GDLIGKIOYRNHDA-UHFFFAOYSA-N
mass: 314.85210
monoisotopicmass: 314.15498
smiles: CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc12
has_alternative_id: CHEBI:3754
has_alternative_id: CHEBI:47359
database cross reference: Beilstein:1323477
database cross reference: CAS:303-49-1
database cross reference: DrugBank:DB01242
database cross reference: Drug_Central:701
database cross reference: KEGG:C06918
database cross reference: KEGG:D07727
database cross reference: LINCS:LSM-3171
database cross reference: PDBeChem:CXX
database cross reference: PMID:12007764
database cross reference: PMID:12084414
database cross reference: PMID:16085036
database cross reference: PMID:17471183
database cross reference: PMID:19747949
database cross reference: PMID:19810911
database cross reference: Patent:CH371799
database cross reference: Patent:US3467650
database cross reference: Reaxys:1323477
database cross reference: Wikipedia:Clomipramine
has exact synonym: 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
has exact synonym: Clomipramine
has_obo_namespace: chebi_ontology
has_related_synonym: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
has_related_synonym: 3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
has_related_synonym: 3-chloroimipramine
has_related_synonym: G 34586
has_related_synonym: chlorimipramine
has_related_synonym: monochlorimipramine
id: CHEBI:47780
in subset: 3 STAR

desipramine
type: Class
subclass of: organonitrogen compound
definition: A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
imported from: chebi.owl
charge: 0
formula: C18H22N2
inchi: InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3
inchikey: HCYAFALTSJYZDH-UHFFFAOYSA-N
mass: 266.38076
monoisotopicmass: 266.17830
smiles: CNCCCN1c2ccccc2CCc2ccccc12
has_alternative_id: CHEBI:4448
has_alternative_id: CHEBI:47393
database cross reference: Beilstein:1432747
database cross reference: CAS:50-47-5
database cross reference: DrugBank:DB01151
database cross reference: Drug_Central:812
database cross reference: HMDB:HMDB0015282
database cross reference: KEGG:C06943
database cross reference: KEGG:D07791
database cross reference: LINCS:LSM-3351
database cross reference: PDBeChem:DSM
database cross reference: PMID:11041270
database cross reference: PMID:11287497
database cross reference: PMID:19328214
database cross reference: PMID:20825390
database cross reference: PMID:24399719
database cross reference: Reaxys:1432747
database cross reference: Wikipedia:Desipramine
has exact synonym: 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine
has exact synonym: Desipramine
has_obo_namespace: chebi_ontology
has_related_synonym: 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE
has_related_synonym: 5-(gamma-methylaminopropyl)iminodibenzyl
has_related_synonym: DMI
has_related_synonym: Desipramin
has_related_synonym: N-(3-methylaminopropyl)iminobibenzyl
has_related_synonym: demethylimipramine
has_related_synonym: desipramina
has_related_synonym: desipramine
has_related_synonym: desipraminum
has_related_synonym: desmethylimipramine
has_related_synonym: monodemethylimipramine
has_related_synonym: norimipramine
id: CHEBI:47781
in subset: 3 STAR

enalapril
type: Class
subclass of: organonitrogen compound
subclass of: organic molecule
definition: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
imported from: chebi.owl
charge: 0
formula: C20H28N2O5
inchi: InChI=1S/C20H28N2O5/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25)/t14-,16-,17-/m0/s1
inchikey: GBXSMTUPTTWBMN-XIRDDKMYSA-N
mass: 376.44670
monoisotopicmass: 376.19982
has_alternative_id: CHEBI:116847
database cross reference: Beilstein:3657467
database cross reference: CAS:75847-73-3
database cross reference: DrugBank:DB00584
database cross reference: Drug_Central:1005
database cross reference: HMDB:HMDB0014722
database cross reference: KEGG:C06977
database cross reference: KEGG:D07892
database cross reference: LINCS:LSM-3282
database cross reference: MetaCyc:CPD0-2065
database cross reference: PMID:10669559
database cross reference: PMID:23030053
database cross reference: PMID:23413003
database cross reference: Patent:EP12401
database cross reference: Patent:US4374829
database cross reference: Wikipedia:Enalapril
has exact synonym: ENALAPRIL
has exact synonym: Enalapril
has exact synonym: N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline
has_obo_namespace: chebi_ontology
has_related_synonym: (S)-1-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline
has_related_synonym: (S)-1-{(S)-2-[1-((S)-Ethoxycarbonyl)-3-phenyl-propylamino]-propionyl}-pyrrolidine-2-carboxylic acid
has_related_synonym: 1-(N-((S)-1-carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl ester
has_related_synonym: analapril
has_related_synonym: enalapril
has_related_synonym: enalaprila
has_related_synonym: enalaprilum
id: CHEBI:4784
in subset: 3 STAR

phenylbutazone
type: Class
subclass of: carbon group molecular entity
definition: A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.
imported from: chebi.owl
charge: 0
formula: C19H20N2O2
inchi: InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
inchikey: VYMDGNCVAMGZFE-UHFFFAOYSA-N
mass: 308.37430
monoisotopicmass: 308.15248
smiles: CCCCC1C(=O)N(N(C1=O)c1ccccc1)c1ccccc1
has_alternative_id: CHEBI:44635
has_alternative_id: CHEBI:8091
database cross reference: Beilstein:290080
database cross reference: CAS:50-33-9
database cross reference: DrugBank:DB00812
database cross reference: Drug_Central:2145
database cross reference: HMDB:HMDB0014950
database cross reference: KEGG:C07440
database cross reference: KEGG:D00510
database cross reference: LINCS:LSM-2219
database cross reference: PDBeChem:P1Z
database cross reference: PMID:11264893
database cross reference: PMID:12692637
database cross reference: PMID:13010905
database cross reference: PMID:13048452
database cross reference: PMID:13747451
database cross reference: PMID:19614844
database cross reference: PMID:20176071
database cross reference: PMID:21668837
database cross reference: PMID:22082440
database cross reference: PMID:22180948
database cross reference: PMID:22245664
database cross reference: PMID:23369749
database cross reference: PMID:23525812
database cross reference: PMID:25287371
database cross reference: PMID:26090772
database cross reference: PMID:26808199
database cross reference: PMID:3425858
database cross reference: PMID:7655439
database cross reference: Reaxys:290080
database cross reference: VSDB:1775
database cross reference: Wikipedia:Phenylbutazone
has exact synonym: 4-butyl-1,2-diphenylpyrazolidine-3,5-dione
has exact synonym: Phenylbutazone
has_obo_namespace: chebi_ontology
has_related_synonym: 3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine
has_related_synonym: 4-BUTYL-1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE
has_related_synonym: 4-n-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
has_related_synonym: Phenbutazone
has_related_synonym: Phenylbutazon
has_related_synonym: fenilbutazona
has_related_synonym: phenylbutazone
has_related_synonym: phenylbutazonum
id: CHEBI:48574
in subset: 3 STAR

agonist
type: Class
subclass of: pharmacological role
definition: Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own.
imported from: chebi.owl
has exact synonym: agonist
has_obo_namespace: chebi_ontology
has_related_synonym: agonista
has_related_synonym: agoniste
has_related_synonym: agonists
id: CHEBI:48705
in subset: 3 STAR

antagonist
type: Class
subclass of: pharmacological role
definition: Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.
imported from: chebi.owl
has exact synonym: antagonist
has_obo_namespace: chebi_ontology
has_related_synonym: antagonista
has_related_synonym: antagoniste
has_related_synonym: antagonists
id: CHEBI:48706
in subset: 3 STAR

etanercept
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
database cross reference: CAS:185243-69-0
database cross reference: DrugBank:DB00005
database cross reference: KEGG:C07897
database cross reference: KEGG:D00742
database cross reference: Patent:US5605690
database cross reference: Patent:WO946476
has exact synonym: Etanercept
has_obo_namespace: chebi_ontology
id: CHEBI:4875
in subset: 2 STAR

etodolac
type: Class
subclass of: carbon group molecular entity
definition: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
imported from: chebi.owl
charge: 0
formula: C17H21NO3
inchi: InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)
inchikey: NNYBQONXHNTVIJ-UHFFFAOYSA-N
mass: 287.35350
monoisotopicmass: 287.15214
smiles: CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12
has_alternative_id: CHEBI:126431
database cross reference: CAS:41340-25-4
database cross reference: DrugBank:DB00749
database cross reference: Drug_Central:1103
database cross reference: HMDB:HMDB0014887
database cross reference: KEGG:D00315
database cross reference: LINCS:LSM-1781
database cross reference: PMID:15369391
database cross reference: PMID:2527995
database cross reference: PMID:28166217
database cross reference: PMID:2970548
database cross reference: Patent:DE2301525
database cross reference: Patent:US3939178
database cross reference: Wikipedia:Etodolac
has exact synonym: (1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid
has exact synonym: ETODOLAC
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
has_related_synonym: (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid
has_related_synonym: 1,3,4,9-tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic acid
has_related_synonym: 1,8-diethyl-1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acid
has_related_synonym: 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-ylacetic acid
has_related_synonym: ETODOLIC ACID
has_related_synonym: etodolac
has_related_synonym: etodolaco
has_related_synonym: etodolacum
id: CHEBI:4909
in subset: 3 STAR

copper(1+)
type: Class
subclass of: ion
imported from: chebi.owl
charge: +1
formula: Cu
inchi: InChI=1S/Cu/q+1
inchikey: VMQMZMRVKUZKQL-UHFFFAOYSA-N
mass: 63.54600
monoisotopicmass: 62.92905
smiles: [Cu+]
has_alternative_id: CHEBI:23379
has_alternative_id: CHEBI:49551
database cross reference: CAS:17493-86-6
database cross reference: Gmelin:15189
database cross reference: PDBeChem:CU1
has exact synonym: copper(1+)
has exact synonym: copper(1+) ion
has exact synonym: copper(I) cation
has_obo_namespace: chebi_ontology
has_related_synonym: COPPER (I) ION
has_related_synonym: Cu(+)
has_related_synonym: copper cation
has_related_synonym: copper(1+) ion
has_related_synonym: copper(I) cation
has_related_synonym: cuprous ion
id: CHEBI:49552
in subset: 3 STAR

indometacin
type: Class
subclass of: organohalogen compound
subclass of: ether
definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
imported from: chebi.owl
charge: 0
formula: C19H16ClNO4
inchi: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
inchikey: CGIGDMFJXJATDK-UHFFFAOYSA-N
mass: 357.78800
monoisotopicmass: 357.07679
has_alternative_id: CHEBI:49660
has_alternative_id: CHEBI:5918
database cross reference: Beilstein:497341
database cross reference: CAS:53-86-1
database cross reference: DrugBank:DB00328
database cross reference: Drug_Central:1440
database cross reference: Gmelin:1446006
database cross reference: HMDB:HMDB0014473
database cross reference: KEGG:C01926
database cross reference: KEGG:D00141
database cross reference: KNApSAcK:C00030512
database cross reference: LINCS:LSM-3275
database cross reference: MetaCyc:CPD-10545
database cross reference: PDBeChem:IMN
database cross reference: PMID:22931205
database cross reference: PMID:23992308
database cross reference: PMID:28166217
database cross reference: PMID:5952296
database cross reference: PMID:6039425
database cross reference: Patent:BE379378
database cross reference: Patent:US3161654
database cross reference: Reaxys:497341
database cross reference: Wikipedia:Indometacin
has exact synonym: [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
has_obo_namespace: chebi_ontology
has_related_synonym: 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid
has_related_synonym: Aconip
has_related_synonym: Indocin
has_related_synonym: Indomethacin
has_related_synonym: indometacin
has_related_synonym: indometacina
has_related_synonym: indometacine
has_related_synonym: indometacinum
has_related_synonym: {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid
id: CHEBI:49662
in subset: 3 STAR

lithium(1+)
type: Class
subclass of: ion
imported from: chebi.owl
charge: +1
formula: Li
inchi: InChI=1S/Li/q+1
inchikey: HBBGRARXTFLTSG-UHFFFAOYSA-N
mass: 6.94100
monoisotopicmass: 7.01545
smiles: [Li+]
has_alternative_id: CHEBI:30143
has_alternative_id: CHEBI:49711
database cross reference: CAS:17341-24-1
database cross reference: DrugBank:DB01356
database cross reference: Gmelin:15205
database cross reference: PDBeChem:LI
has exact synonym: lithium(1+)
has exact synonym: lithium(1+) ion
has exact synonym: lithium(I) cation
has_obo_namespace: chebi_ontology
has_related_synonym: LITHIUM ION
has_related_synonym: Li(+)
has_related_synonym: Lithium, ion (Li1+)
has_related_synonym: lithium cation
has_related_synonym: lithium, ion
id: CHEBI:49713
in subset: 3 STAR

fenoprofen
type: Class
subclass of: carbon group molecular entity
definition: A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.
imported from: chebi.owl
charge: 0
formula: C15H14O3
inchi: InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17)
inchikey: RDJGLLICXDHJDY-UHFFFAOYSA-N
mass: 242.26990
monoisotopicmass: 242.09429
smiles: CC(C(O)=O)c1cccc(Oc2ccccc2)c1
has_alternative_id: CHEBI:355534
database cross reference: CAS:31879-05-7
database cross reference: DrugBank:DB00573
database cross reference: Drug_Central:1154
database cross reference: KEGG:C06997
database cross reference: KEGG:D02350
database cross reference: PMID:21328296
database cross reference: PMID:21342694
database cross reference: PMID:25554116
database cross reference: PMID:28166217
database cross reference: PMID:30168706
database cross reference: PMID:4616811
database cross reference: Patent:US3600437
database cross reference: Reaxys:2118687
database cross reference: Wikipedia:_Fenoprofen
has exact synonym: 2-(3-phenoxyphenyl)propanoic acid
has exact synonym: FENOPROFEN
has exact synonym: Fenoprofen
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-2-(3-phenoxyphenyl)propionic acid
has_related_synonym: (+-)-m-phenoxyhydratropic acid
has_related_synonym: 2-(3-phenoxyphenyl)propionic acid
has_related_synonym: 2-(m-phenoxyphenyl)propionic acid
has_related_synonym: alpha-(m-phenoxyphenyl)propionic acid
has_related_synonym: alpha-methyl-3-phenoxybenzeneacetic acid
has_related_synonym: fenoprofen
has_related_synonym: fenoprofene
has_related_synonym: fenoprofeno
has_related_synonym: fenoprofenum
id: CHEBI:5004
in subset: 3 STAR

estrogen
type: Class
subclass of: hormone
definition: A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.
imported from: chebi.owl
database cross reference: Wikipedia:Estrogen
has_obo_namespace: chebi_ontology
has_related_synonym: Estrogene
has_related_synonym: Oestrogen
has_related_synonym: Oestrogene
has_related_synonym: estrogene
has_related_synonym: estrogenes
has_related_synonym: estrogenes Hormon
has_related_synonym: estrogeno
has_related_synonym: estrogenos
has_related_synonym: estrogens
has_related_synonym: oestrogen
has_related_synonym: oestrogene
has_related_synonym: oestrogenes
has_related_synonym: oestrogens
id: CHEBI:50114
in subset: 3 STAR

rosiglitazone
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
charge: 0
formula: C18H19N3O3S
inchi: InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
inchikey: YASAKCUCGLMORW-UHFFFAOYSA-N
mass: 357.42700
monoisotopicmass: 357.11471
smiles: CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1
database cross reference: Beilstein:7082202
database cross reference: CAS:122320-73-4
database cross reference: DrugBank:DB00412
database cross reference: Drug_Central:2405
database cross reference: LINCS:LSM-1949
database cross reference: PMID:17259370
database cross reference: PMID:30225267
database cross reference: PMID:31936729
database cross reference: PMID:32234642
database cross reference: PMID:33650786
database cross reference: PMID:33746608
database cross reference: Patent:EP306228
database cross reference: Patent:US5002953
database cross reference: Wikipedia:Rosiglitazone
has exact synonym: 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione
has_obo_namespace: chebi_ontology
has_related_synonym: 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
has_related_synonym: BRL-49653
has_related_synonym: rosiglitazona
has_related_synonym: rosiglitazone
has_related_synonym: rosiglitazonum
id: CHEBI:50122
in subset: 3 STAR

brexanolone
type: Class
subclass of: lipid
definition: A 3-hydroxy-5alpha-pregnan-20-one in which the hydroxy group at position 3 has alpha-configuration. It is a metabolite of the sex hormone progesterone and used for the treatment of postpartum depression in women.
imported from: chebi.owl
charge: 0
formula: C21H34O2
inchi: InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1
inchikey: AURFZBICLPNKBZ-SYBPFIFISA-N
mass: 318.49346
monoisotopicmass: 318.25588
has_alternative_id: CHEBI:32924
has_alternative_id: CHEBI:34347
database cross reference: Beilstein:3211363
database cross reference: CAS:516-54-1
database cross reference: DrugBank:DB11859
database cross reference: FooDB:FDB022630
database cross reference: HMDB:HMDB0001449
database cross reference: KEGG:C13712
database cross reference: KEGG:D11149
database cross reference: LINCS:LSM-19998
database cross reference: LIPID_MAPS_instance:LMST02030130
database cross reference: PMID:10625505
database cross reference: PMID:11739473
database cross reference: PMID:19290593
database cross reference: PMID:28370307
database cross reference: PMID:28619476
database cross reference: PMID:28666923
database cross reference: PMID:28779545
database cross reference: PMID:29453777
database cross reference: PMID:29636114
database cross reference: PMID:30177236
database cross reference: PMID:30362283
database cross reference: PMID:30481569
database cross reference: PMID:30701996
database cross reference: PMID:9501247
database cross reference: Wikipedia:Allopregnanolone
has exact synonym: 3alpha-hydroxy-5alpha-pregnan-20-one
has_obo_namespace: chebi_ontology
has_related_synonym: (3alpha,5alpha)-3-hydroxypregnan-20-one
has_related_synonym: 3alpha,5alpha-THP
has_related_synonym: 3alpha,5alpha-tetrahydroprogesterone
has_related_synonym: 3alpha-OH DHP
has_related_synonym: 3alpha-hydroxy-5alpha-dihydroprogesterone
has_related_synonym: 3alpha-hydroxy-5alpha-pregnan-20-one
has_related_synonym: 5alpha-pregnan-3alpha-ol-20-one
has_related_synonym: SAGE-547
has_related_synonym: SGE-102
has_related_synonym: Zulresso
has_related_synonym: allopregnan-3alpha-ol-20-one
has_related_synonym: allopregnanolone
has_related_synonym: allotetrahydroprogesterone
has_related_synonym: brexanolona
has_related_synonym: brexanolone
has_related_synonym: brexanolonum
id: CHEBI:50169
in subset: 3 STAR

selegiline
type: Class
subclass of: organonitrogen compound
subclass of: organic molecule
imported from: chebi.owl
charge: 0
formula: C13H17N
inchi: InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3
inchikey: MEZLKOACVSPNER-UHFFFAOYSA-N
mass: 187.28082
monoisotopicmass: 187.13610
smiles: CC(Cc1ccccc1)N(C)CC#C
database cross reference: Beilstein:2092580
database cross reference: DrugBank:DB01037
has exact synonym: N-methyl-N-(1-methyl-2-phenylethyl)prop-2-yn-1-amine
has_obo_namespace: chebi_ontology
has_related_synonym: selegilina
has_related_synonym: selegiline
has_related_synonym: selegilinum
id: CHEBI:50217
in subset: 3 STAR

butenolide
type: Class
subclass of: furans
subclass of: gamma-lactone
definition: A gamma-lactone that consists of a 2-furanone skeleton and its substituted derivatives.
imported from: chebi.owl
charge: 0
formula: C4H4O2
mass: 84.074
monoisotopicmass: 84.02113
has_alternative_id: CHEBI:22960
has_alternative_id: CHEBI:38121
database cross reference: Wikipedia:Butenolide
has exact synonym: furan-2-one
has_obo_namespace: chebi_ontology
has_related_synonym: 2-furanone
has_related_synonym: butenolides
id: CHEBI:50523
in subset: 3 STAR

dityrosine
type: Class
subclass of: organonitrogen compound
subclass of: organic molecule
definition: A biphenyl compound comprising two tyrosine residues linked at carbon-3 of their benzene rings.
imported from: chebi.owl
charge: 0
formula: C18H20N2O6
inchi: InChI=1S/C18H20N2O6/c19-13(17(23)24)7-9-1-3-15(21)11(5-9)12-6-10(2-4-16(12)22)8-14(20)18(25)26/h1-6,13-14,21-22H,7-8,19-20H2,(H,23,24)(H,25,26)
inchikey: OQALFHMKVSJFRR-UHFFFAOYSA-N
mass: 360.36128
monoisotopicmass: 360.13214
smiles: NC(Cc1ccc(O)c(c1)-c1cc(CC(N)C(O)=O)ccc1O)C(O)=O
database cross reference: Beilstein:2228674
database cross reference: CAS:980-21-2
database cross reference: PMID:15589368
database cross reference: PMID:17019703
database cross reference: PMID:24351276
database cross reference: PMID:24573970
has exact synonym: 3,3'-(6,6'-dihydroxybiphenyl-3,3'-diyl)bis(2-aminopropanoic acid)
has_obo_namespace: chebi_ontology
has_related_synonym: 3,3'-dityrosine
has_related_synonym: alpha,alpha'-diamino-6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-dipropanoic acid
has_related_synonym: bityrosine
has_related_synonym: o,o-dityrosine
id: CHEBI:50607
in subset: 3 STAR

N-acetyl-D-glucosamine
type: Class
subclass of: carbon group molecular entity
definition: The D isomer of N-acetylglucosamine.
imported from: chebi.owl
charge: 0
formula: C8H15NO6
inchi: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8?/m1/s1
inchikey: OVRNDRQMDRJTHS-RTRLPJTCSA-N
mass: 221.20780
monoisotopicmass: 221.08994
database cross reference: Beilstein:1913592
database cross reference: CAS:7512-17-6
database cross reference: DrugBank:DB00141
database cross reference: GlyGen:G64581RP
database cross reference: GlyTouCan:G64581RP
database cross reference: KEGG:C00140
database cross reference: PDBeChem:NAG
database cross reference: PMID:11950472
database cross reference: PMID:21487204
database cross reference: PMID:6174502
database cross reference: PMID:7688662
has exact synonym: 2-acetamido-2-deoxy-D-glucopyranose
has exact synonym: N-Acetyl-D-glucosamine
has exact synonym: N-acetyl-D-glucosamine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Acetamido-2-deoxy-D-glucose
has_related_synonym: GlcNAc
has_related_synonym: N-Acetylchitosamine
has_related_synonym: WURCS=2.0/1,1,0/[a2122h-1x_1-5_2*NCC/3=O]/1/
id: CHEBI:506227
in subset: 3 STAR

loxapine
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
charge: 0
formula: C18H18ClN3O
inchi: InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
inchikey: XJGVXQDUIWGIRW-UHFFFAOYSA-N
mass: 327.80784
monoisotopicmass: 327.11384
smiles: CN1CCN(CC1)C1=Nc2ccccc2Oc2ccc(Cl)cc12
has_alternative_id: CHEBI:50839
has_alternative_id: CHEBI:6548
database cross reference: Beilstein:626753
database cross reference: CAS:1977-10-2
database cross reference: DrugBank:DB00408
database cross reference: Drug_Central:1613
database cross reference: KEGG:C07104
database cross reference: KEGG:D02340
database cross reference: LINCS:LSM-2881
database cross reference: Patent:NL6406089
database cross reference: Patent:US3412193
database cross reference: Patent:US3546226
database cross reference: Wikipedia:Loxapine
has exact synonym: 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine
has exact synonym: Loxapine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine
has_related_synonym: Cloxazepine
has_related_synonym: loxapina
has_related_synonym: loxapine
has_related_synonym: loxapinum
has_related_synonym: oxilapine
id: CHEBI:50841
in subset: 3 STAR

organic molecular entity
type: Class
subclass of: carbon group molecular entity
definition: Any molecular entity that contains carbon.
imported from: chebi.owl
has_alternative_id: CHEBI:25700
has_alternative_id: CHEBI:33244
has_obo_namespace: chebi_ontology
has_related_synonym: organic compounds
has_related_synonym: organic entity
has_related_synonym: organic molecular entities
id: CHEBI:50860
in subset: 3 STAR

flumazenil
type: Class
subclass of: organohalogen compound
subclass of: organic molecule
definition: An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
imported from: chebi.owl
charge: 0
formula: C15H14FN3O3
inchi: InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
inchikey: OFBIFZUFASYYRE-UHFFFAOYSA-N
mass: 303.289
monoisotopicmass: 303.10192
database cross reference: Beilstein:4763661
database cross reference: CAS:78755-81-4
database cross reference: DrugBank:DB01205
database cross reference: Drug_Central:1195
database cross reference: HMDB:HMDB0015336
database cross reference: KEGG:C07825
database cross reference: KEGG:D00697
database cross reference: LINCS:LSM-4228
database cross reference: PMID:11881583
database cross reference: PMID:23126253
database cross reference: PMID:23431889
database cross reference: PMID:24563235
database cross reference: PMID:26324010
database cross reference: PMID:26469689
database cross reference: Reaxys:4763661
database cross reference: Wikipedia:Flumazenil
has exact synonym: ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
has_obo_namespace: chebi_ontology
has_related_synonym: Anexate
has_related_synonym: Lanexat
has_related_synonym: flumazenil
has_related_synonym: flumazenilo
has_related_synonym: flumazenilum
id: CHEBI:5103
in subset: 3 STAR

minaprine
type: Class
subclass of: organonitrogen compound
imported from: chebi.owl
charge: 0
formula: C17H22N4O
inchi: InChI=1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20)
inchikey: LDMWSLGGVTVJPG-UHFFFAOYSA-N
mass: 298.38294
monoisotopicmass: 298.17936
smiles: Cc1cc(nnc1NCCN1CCOCC1)-c1ccccc1
database cross reference: Beilstein:1219740
database cross reference: CAS:25905-77-5
database cross reference: DrugBank:DB00805
database cross reference: Drug_Central:1812
database cross reference: KEGG:D05039
database cross reference: LINCS:LSM-2037
database cross reference: Patent:DE2229215
database cross reference: Patent:US4169158
has exact synonym: 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine
has_obo_namespace: chebi_ontology
has_related_synonym: 4-(2-((4-Methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine
has_related_synonym: 4-Methyl-3-(2-morpholinoethylamino)-6-phenylpyridazin
has_related_synonym: N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine
has_related_synonym: minaprina
has_related_synonym: minaprine
has_related_synonym: minaprinum
id: CHEBI:51038
in subset: 3 STAR

chemical role
type: Class
subclass of: role
definition: A role played by the molecular entity or part thereof within a chemical context.
imported from: chebi.owl
imported from: chiro.owl
has_obo_namespace: chebi_ontology
id: CHEBI:51086
in subset: 3 STAR

nitrogen molecular entity
type: Class
subclass of: pnictogen molecular entity
imported from: chebi.owl
has_alternative_id: CHEBI:25556
has_alternative_id: CHEBI:7594
database cross reference: KEGG:C06061
has_obo_namespace: chebi_ontology
has_related_synonym: Nitrogenous compounds
has_related_synonym: nitrogen compounds
has_related_synonym: nitrogen molecular entities
id: CHEBI:51143
in subset: 3 STAR

fluoxetine
type: Class
subclass of: antidepressant
definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
imported from: chebi.owl
charge: 0
formula: C17H18F3NO
mass: 309.32610
monoisotopicmass: 309.13405
database cross reference: Beilstein:39914106
database cross reference: CAS:54910-89-3
database cross reference: DrugBank:DB00472
database cross reference: HMDB:HMDB0014615
database cross reference: KEGG:D00326
database cross reference: PMID:19144769
database cross reference: PMID:22903652
database cross reference: PMID:22923967
database cross reference: PMID:23885544
database cross reference: PMID:24184049
database cross reference: PMID:24399719
database cross reference: PMID:24464553
database cross reference: PMID:24997906
database cross reference: PMID:25448156
database cross reference: PMID:25639887
database cross reference: PMID:25671301
database cross reference: PMID:8694321
database cross reference: Patent:DE2500110
database cross reference: Patent:US4314081
database cross reference: Reaxys:3991406
database cross reference: Wikipedia:Fluoxetine
has exact synonym: rac-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-N-methyl-3-phenyl-3-((alpha,alpha,alpha-trifluoro-p-tolyl)oxy)propylamine
has_related_synonym: Prozac
has_related_synonym: fluoxetina
has_related_synonym: fluoxetine
has_related_synonym: fluoxetinum
id: CHEBI:5118
in subset: 3 STAR

fluphenazine
type: Class
subclass of: organohalogen compound
subclass of: phenothiazines
definition: A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position.
imported from: chebi.owl
charge: 0
formula: C22H26F3N3OS
inchi: InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
inchikey: PLDUPXSUYLZYBN-UHFFFAOYSA-N
mass: 437.52200
monoisotopicmass: 437.17487
database cross reference: Beilstein:1189506
database cross reference: Beilstein:61643
database cross reference: CAS:69-23-8
database cross reference: DrugBank:DB00623
database cross reference: Drug_Central:1212
database cross reference: Gmelin:1231182
database cross reference: HMDB:HMDB0014761
database cross reference: KEGG:C07010
database cross reference: KEGG:D07977
database cross reference: LINCS:LSM-3226
database cross reference: PMID:13950763
database cross reference: PMID:16117689
database cross reference: PMID:1650428
database cross reference: PMID:16839522
database cross reference: PMID:25595294
database cross reference: PMID:5128930
database cross reference: Patent:GB829246
database cross reference: Patent:GB833474
database cross reference: Patent:US3058979
database cross reference: Patent:US3194733
database cross reference: Reaxys:61643
database cross reference: Wikipedia:Fluphenazine
has exact synonym: 2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethan-1-ol
has exact synonym: Fluphenazine
has_obo_namespace: chebi_ontology
has_related_synonym: 1-(2-hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine
has_related_synonym: 10-(3'-(4''-(beta-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine
has_related_synonym: 10-(3-(2-hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine
has_related_synonym: 2-(4-(3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol
has_related_synonym: 2-(trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine
has_related_synonym: 4-(3-(-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
has_related_synonym: 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol
has_related_synonym: 4-(3-(2-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol
has_related_synonym: Fluorfenazine
has_related_synonym: Fluorophenazine
has_related_synonym: Fluorphenazine
has_related_synonym: Triflumethazine
has_related_synonym: flufenazina
has_related_synonym: fluphenazine
has_related_synonym: fluphenazinum
id: CHEBI:5123
in subset: 3 STAR

thioester
type: Class
subclass of: thiocarboxylic ester
subclass of: carbonyl compound
definition: A compound of general formula RC(=O)SR'. Compare with thionoester, RC(=S)OR'.
imported from: chebi.owl
charge: 0
formula: COSR2
mass: 60.07500
monoisotopicmass: 59.96699
smiles: [*]C(=O)S[*]
has_obo_namespace: chebi_ontology
has_related_synonym: thio ester
has_related_synonym: thioesters
has_related_synonym: thiol ester
id: CHEBI:51277
in subset: 3 STAR

flurazepam
type: Class
subclass of: organohalogen compound
subclass of: organonitrogen compound
definition: A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a 2-(diethylamino)ethyl group, 2-fluorophenyl group and chloro group at positions 1, 5 and 7, respectively. It is a partial agonist of GABAA receptors and used for the treatment of insomnia.
imported from: chebi.owl
charge: 0
formula: C21H23ClFN3O
inchi: InChI=1S/C21H23ClFN3O/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23/h5-10,13H,3-4,11-12,14H2,1-2H3
inchikey: SAADBVWGJQAEFS-UHFFFAOYSA-N
mass: 387.880
monoisotopicmass: 387.15137
database cross reference: CAS:17617-23-1
database cross reference: DrugBank:DB00690
database cross reference: Drug_Central:1218
database cross reference: HMDB:HMDB0014828
database cross reference: KEGG:D00329
database cross reference: PDBeChem:FL7
database cross reference: PMID:16501350
database cross reference: PMID:20002022
database cross reference: PMID:23035248
database cross reference: PMID:2863335
database cross reference: Wikipedia:Flurazepam
has exact synonym: 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
has_obo_namespace: chebi_ontology
has_related_synonym: Insumin
has_related_synonym: Ro 5-6901
has_related_synonym: flurazepam
has_related_synonym: flurazepamum
id: CHEBI:5128
in subset: 3 STAR

fluvoxamine
type: Class
subclass of: organohalogen compound
subclass of: ether
definition: An oxime O-ether that is benzene substituted by a (1E)-N-(2-aminoethoxy)-5-methoxypentanimidoyl group at position 1 and a trifluoromethyl group at position 4. It is a selective serotonin reuptake inhibitor that is used for the treatment of obsessive-compulsive disorder.
imported from: chebi.owl
charge: 0
formula: C15H21F3N2O2
inchi: InChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3/b20-14+
inchikey: CJOFXWAVKWHTFT-XSFVSMFZSA-N
mass: 318.340
monoisotopicmass: 318.15551
smiles: COCCCC\C(=N/OCCN)C1=CC=C(C=C1)C(F)(F)F
database cross reference: Beilstein:5583954
database cross reference: CAS:54739-18-3
database cross reference: Chemspider:4481878
database cross reference: DrugBank:DB00176
database cross reference: Drug_Central:1230
database cross reference: HMDB:HMDB0014322
database cross reference: KEGG:C07571
database cross reference: KEGG:D07984
database cross reference: MetaCyc:CPD-20520
database cross reference: PDBeChem:FVX
database cross reference: PMID:10456487
database cross reference: PMID:11825104
database cross reference: PMID:12107854
database cross reference: PMID:15686112
database cross reference: PMID:16316311
database cross reference: PMID:18976545
database cross reference: PMID:20025739
database cross reference: PMID:20573265
database cross reference: PMID:22859721
database cross reference: PMID:24121440
database cross reference: PMID:29379174
database cross reference: PMID:30690950
database cross reference: PMID:30734885
database cross reference: PMID:31807102
database cross reference: PMID:31807753
database cross reference: PMID:32618683
database cross reference: PMID:32672818
database cross reference: PMID:33180097
database cross reference: PMID:33392622
database cross reference: PMID:7988100
database cross reference: PMID:9164424
database cross reference: Patent:NL7503310
database cross reference: Patent:US4085225
database cross reference: Wikipedia:Fluvoxamine
has exact synonym: (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-(2-aminoethyl)oxime
has exact synonym: Fluvoxamine
has_obo_namespace: chebi_ontology
has_related_synonym: fluvoxamina
has_related_synonym: fluvoxamine
has_related_synonym: fluvoxaminum
id: CHEBI:5138
in subset: 3 STAR

fosinopril
type: Class
subclass of: organonitrogen compound
subclass of: ester
definition: A phosphinate ester-containing N-acyl derivative of (4S)-cyclohexyl-L-proline. It is used for the treatment of hypertension and heart failure. A pro-drug, it is hydrolysed in vivo to the corresponding phosphininc acid, fosinoprilat, which is the active metabolite.
imported from: chebi.owl
charge: 0
formula: C30H46NO7P
inchi: InChI=1S/C30H46NO7P/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35)/t25-,26+,30?,39?/m1/s1
inchikey: BIDNLKIUORFRQP-FKDWWROVSA-N
mass: 563.66250
monoisotopicmass: 563.30119
has_alternative_id: CHEBI:159901
has_alternative_id: CHEBI:288733
database cross reference: Beilstein:8176492
database cross reference: CAS:98048-97-6
database cross reference: DrugBank:DB00492
database cross reference: KEGG:C07016
database cross reference: KEGG:D07992
database cross reference: LINCS:LSM-6485
database cross reference: PMID:11937741
database cross reference: PMID:18209565
database cross reference: PMID:22729889
database cross reference: PMID:8285178
database cross reference: PMID:9195116
database cross reference: Patent:CN101367839
database cross reference: Patent:EP2264039
database cross reference: Patent:US2010297711
database cross reference: Patent:US4337201
has exact synonym: (4S)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)-L-proline
has exact synonym: Fosinopril
has_obo_namespace: chebi_ontology
has_related_synonym: (2S,4S)-4-cyclohexyl-1-[2-[(2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid
has_related_synonym: (2S,4S)-4-cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid
has_related_synonym: (S)-4-Cyclohexyl-1-{2-[(2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl]-acetyl}-pyrrolidine-2-carboxylic acid
has_related_synonym: fosinopril
id: CHEBI:5163
in subset: 3 STAR

biochemical role
type: Class
subclass of: biological role
definition: A biological role played by the molecular entity or part thereof within a biochemical context.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:52206
in subset: 3 STAR

pharmacological role
type: Class
subclass of: biological role
definition: A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:52210
in subset: 3 STAR

physiological role
type: Class
subclass of: biological role
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:52211
in subset: 1 STAR

pharmaceutical
type: Class
subclass of: application
definition: Any substance introduced into a living organism with therapeutic or diagnostic purpose.
imported from: chebi.owl
has_alternative_id: CHEBI:33293
has_alternative_id: CHEBI:33294
has_obo_namespace: chebi_ontology
has_related_synonym: farmaco
has_related_synonym: medicament
has_related_synonym: pharmaceuticals
id: CHEBI:52217
in subset: 3 STAR

donepezil
type: Class
subclass of: cholinesterase inhibitor therapy
definition: A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
imported from: chebi.owl
charge: 0
formula: C24H29NO3
inchi: InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
inchikey: ADEBPBSSDYVVLD-UHFFFAOYSA-N
mass: 379.500
monoisotopicmass: 379.21474
database cross reference: Beilstein:7081955
database cross reference: CAS:120014-06-4
database cross reference: DrugBank:DB00843
database cross reference: Drug_Central:946
database cross reference: KEGG:D07869
database cross reference: LINCS:LSM-1598
database cross reference: Reaxys:7081955
database cross reference: Wikipedia:Donepezil
has_obo_namespace: chebi_ontology
has_related_synonym: donepezil
has_related_synonym: donepezilo
has_related_synonym: donepezilum
id: CHEBI:53289
in subset: 3 STAR

glucosamine
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
charge: 0
formula: C6H13NO5
mass: 179.171
monoisotopicmass: 179.07937
database cross reference: DrugBank:DB01296
database cross reference: KEGG:C01811
has exact synonym: 2-amino-2-deoxyglucose
has exact synonym: Glucosamine
has exact synonym: glucosamine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Amino-2-deoxy-glucose
has_related_synonym: GlcN
has_related_synonym: Glucosamin
has_related_synonym: Glukosamin
id: CHEBI:5417
in subset: 3 STAR

glyceraldehyde
type: Class
subclass of: chalcogen molecular entity
subclass of: carbon group molecular entity
definition: An aldotriose comprising propanal having hydroxy groups at the 2- and 3-positions. It plays role in the formation of advanced glycation end-products (AGEs), a deleterious accompaniment to ageing.
imported from: chebi.owl
charge: 0
formula: C3H6O3
inchi: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2
inchikey: MNQZXJOMYWMBOU-UHFFFAOYSA-N
mass: 90.07794
monoisotopicmass: 90.03169
smiles: [H]C(=O)C(O)CO
has_alternative_id: CHEBI:24343
has_alternative_id: CHEBI:387614
database cross reference: Beilstein:635844
database cross reference: CAS:367-47-5
database cross reference: CAS:56-82-6
database cross reference: DrugBank:DB02536
database cross reference: Gmelin:164389
database cross reference: HMDB:HMDB0001051
database cross reference: KEGG:C02154
database cross reference: KNApSAcK:C00007413
database cross reference: MetaCyc:CPD0-1551
database cross reference: PMID:18087047
database cross reference: PMID:18256486
database cross reference: PMID:18791692
database cross reference: PMID:20371493
database cross reference: PMID:21707087
database cross reference: PMID:23543734
database cross reference: PMID:9506998
database cross reference: Reaxys:635844
database cross reference: Wikipedia:Glyceraldehyde
has exact synonym: 2,3-dihydroxypropanal
has exact synonym: Glyceraldehyde
has exact synonym: glyceraldehyde
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-glyceraldehyde
has_related_synonym: 2,3-Dihydroxypropanal
has_related_synonym: 2,3-Dihydroxypropionaldehyde
has_related_synonym: Aldotriose
has_related_synonym: DL-glyceraldehyde
has_related_synonym: Glyceraldehyd
has_related_synonym: Glycerinaldehyd
has_related_synonym: Glycerose
has_related_synonym: Glyzerinaldehyd
has_related_synonym: alpha,beta-dihydroxypropionaldehyde
has_related_synonym: gliceraldehido
has_related_synonym: glyceric aldehyde
has_related_synonym: glycerinaldehyde
has_related_synonym: glycerinformal
has_related_synonym: glycerose
id: CHEBI:5445
in subset: 3 STAR

haloperidol
type: Class
subclass of: antipsychotic agent
definition: A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.
imported from: chebi.owl
charge: 0
formula: C21H23ClFNO2
inchi: InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
inchikey: LNEPOXFFQSENCJ-UHFFFAOYSA-N
mass: 375.86400
monoisotopicmass: 375.14013
database cross reference: Beilstein:331267
database cross reference: CAS:52-86-8
database cross reference: DrugBank:DB00502
database cross reference: Drug_Central:1353
database cross reference: KEGG:C01814
database cross reference: KEGG:D00136
database cross reference: LINCS:LSM-3512
database cross reference: PMID:10628896
database cross reference: PMID:11304647
database cross reference: PMID:25007358
database cross reference: PMID:6725621
database cross reference: PMID:7602118
database cross reference: Patent:BE577977
database cross reference: Patent:GB895309
database cross reference: Patent:US3438991
database cross reference: Reaxys:331267
database cross reference: Wikipedia:Haloperidol
has exact synonym: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
has_obo_namespace: chebi_ontology
has_related_synonym: 1-(3-p-fluorobenzoylpropyl)-4-p-chlorophenyl-4-hydroxypiperidine
has_related_synonym: 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone
has_related_synonym: 4'-fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone
has_related_synonym: 4-(4-(para-chlorophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone
has_related_synonym: 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one
has_related_synonym: Haldol
has_related_synonym: gamma-(4-(p-chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone
has_related_synonym: haloperidol
has_related_synonym: haloperidolum
id: CHEBI:5613
in subset: 3 STAR

malonaldehyde
type: Class
subclass of: organic molecule
definition: A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.
imported from: chebi.owl
charge: 0
formula: C3H4O2
inchi: InChI=1S/C3H4O2/c4-2-1-3-5/h2-3H,1H2
inchikey: WSMYVTOQOOLQHP-UHFFFAOYSA-N
mass: 72.06270
monoisotopicmass: 72.02113
smiles: O=CCC=O
has_alternative_id: CHEBI:43895
database cross reference: Beilstein:1209262
database cross reference: CAS:542-78-9
database cross reference: DrugBank:DB03057
database cross reference: Gmelin:362229
database cross reference: KEGG:C19440
database cross reference: PDBeChem:MDD
database cross reference: PMID:15583011
database cross reference: PMID:17548130
database cross reference: PMID:23900424
database cross reference: PMID:24168430
database cross reference: PMID:28600633
database cross reference: PMID:28600933
database cross reference: PMID:28783520
database cross reference: PMID:29348025
database cross reference: Reaxys:1209262
has exact synonym: malonaldehyde
has exact synonym: propanedial
has_obo_namespace: chebi_ontology
has_related_synonym: 1,3-Propanedial
has_related_synonym: 1,3-Propanedialdehyde
has_related_synonym: 1,3-Propanedione
has_related_synonym: MDA
has_related_synonym: MDD
has_related_synonym: Malondialdehyde
has_related_synonym: Malonic aldehyde
has_related_synonym: Malonic dialdehyde
has_related_synonym: Malonodialdehyde
has_related_synonym: Malonyldialdehyde
id: CHEBI:566274
in subset: 3 STAR

heterocyclic compound
type: Class
subclass of: cyclic compound
definition: A cyclic compound having as ring members atoms of at least two different elements.
imported from: chebi.owl
has exact synonym: Heterocyclic compound
has_obo_namespace: chebi_ontology
has_related_synonym: compuesto heterociclico
has_related_synonym: compuestos heterociclicos
has_related_synonym: heterocycle
has_related_synonym: heterocyclic compounds
id: CHEBI:5686
in subset: 3 STAR

O-acetyl-L-carnitine
type: Class
subclass of: organic molecule
definition: An O-acyl-L-carnitine where the acyl group specified is acetyl. It facilitates movement of acetyl-CoA into the matrices of mammalian mitochondria during the oxidation of fatty acids.
imported from: chebi.owl
charge: 0
formula: C9H17NO4
inchi: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1
inchikey: RDHQFKQIGNGIED-MRVPVSSYSA-N
mass: 203.23560
monoisotopicmass: 203.11576
smiles: CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C
database cross reference: Beilstein:3667658
database cross reference: CAS:3040-38-8
database cross reference: Drug_Central:64
database cross reference: HMDB:HMDB0000201
database cross reference: KEGG:C02571
database cross reference: MetaCyc:O-ACETYLCARNITINE
database cross reference: PMID:22770225
database cross reference: Reaxys:3667658
database cross reference: Wikipedia:Acetyl-L-carnitine
has exact synonym: (3R)-3-(acetyloxy)-4-(trimethylazaniumyl)butanoate
has_obo_namespace: chebi_ontology
has_related_synonym: (-)-Acetylcarnitine
has_related_synonym: (R)-Acetylcarnitine
has_related_synonym: Acetyl-L-(-)-carnitine
has_related_synonym: Acetyl-L-carnitine
has_related_synonym: L-Acetylcarnitine
has_related_synonym: L-Carnitine acetyl ester
has_related_synonym: L-O-Acetylcarnitine
has_related_synonym: O-acetyl-(R)-carnitine
has_related_synonym: R-Acetylcarnitine
id: CHEBI:57589
in subset: 3 STAR

3-mercaptopyruvate
type: Class
subclass of: ion
definition: The conjugate base of 3-mercaptopyruvic acid.
imported from: chebi.owl
charge: -1
formula: C3H3O3S
inchi: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1
inchikey: OJOLFAIGOXZBCI-UHFFFAOYSA-M
mass: 119.11900
monoisotopicmass: 118.98084
smiles: [O-]C(=O)C(=O)CS
database cross reference: Beilstein:3933339
has exact synonym: 2-oxo-3-sulfanylpropanoate
has_obo_namespace: chebi_ontology
has_related_synonym: 2-oxo-3-sulfanylpropanoate
id: CHEBI:57678
in subset: 3 STAR

ibuprofen
type: Class
subclass of: carbon group molecular entity
definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
imported from: chebi.owl
charge: 0
formula: C13H18O2
inchi: InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
inchikey: HEFNNWSXXWATRW-UHFFFAOYSA-N
mass: 206.28082
monoisotopicmass: 206.13068
smiles: CC(C)Cc1ccc(cc1)C(C)C(O)=O
database cross reference: Beilstein:2049713
database cross reference: CAS:15687-27-1
database cross reference: DrugBank:DB01050
database cross reference: Drug_Central:1407
database cross reference: HMDB:HMDB0001925
database cross reference: KEGG:C01588
database cross reference: KEGG:D00126
database cross reference: LINCS:LSM-1354
database cross reference: PMID:11433218
database cross reference: PMID:12723739
database cross reference: PMID:14562167
database cross reference: PMID:15506544
database cross reference: PMID:16176022
database cross reference: PMID:18335846
database cross reference: PMID:18697608
database cross reference: PMID:21368281
database cross reference: PMID:24168233
database cross reference: PMID:25708941
database cross reference: PMID:25915907
database cross reference: PMID:29756342
database cross reference: Patent:GB971700
database cross reference: Patent:US3228831
database cross reference: Patent:US3385886
database cross reference: Patent:US5215755
database cross reference: Patent:US6727286
database cross reference: Reaxys:2049713
database cross reference: Wikipedia:Ibuprofen
has exact synonym: 2-[4-(2-methylpropyl)phenyl]propanoic acid
has exact synonym: Ibuprofen
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-2-(p-isobutylphenyl)propionic acid
has_related_synonym: (+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid
has_related_synonym: (+-)-ibuprofen
has_related_synonym: (+-)-p-isobutylhydratropic acid
has_related_synonym: (4-isobutylphenyl)-alpha-methylacetic acid
has_related_synonym: (RS)-ibuprofen
has_related_synonym: 2-(4-isobutylphenyl)propanoic acid
has_related_synonym: 4-isobutylhydratropic acid
has_related_synonym: Adran
has_related_synonym: Advil
has_related_synonym: Amibufen
has_related_synonym: Anco
has_related_synonym: Anflagen
has_related_synonym: Apsifen
has_related_synonym: Bluton
has_related_synonym: Brufen
has_related_synonym: Brufort
has_related_synonym: Buburone
has_related_synonym: Butylenin
has_related_synonym: Dolgin
has_related_synonym: Dolgirid
has_related_synonym: Dolgit
has_related_synonym: Dolo-Dolgit
has_related_synonym: Ebufac
has_related_synonym: Epobron
has_related_synonym: Femadon
has_related_synonym: Haltran
has_related_synonym: Ibu-Attritin
has_related_synonym: Ibumetin
has_related_synonym: Ibuprocin
has_related_synonym: Ibutid
has_related_synonym: Inabrin
has_related_synonym: Inoven
has_related_synonym: Lamidon
has_related_synonym: Lebrufen
has_related_synonym: Liptan
has_related_synonym: Medipren
has_related_synonym: Motrin
has_related_synonym: Mynosedin

perazine
type: Class
subclass of: organonitrogen compound
subclass of: phenothiazines
definition: A phenothiazine derivative in which 10H-phenothiazinecarries a 3-(4-methylpiperazin-1-yl)propyl substituent at the N-10 position.
imported from: chebi.owl
charge: 0
formula: C20H25N3S
inchi: InChI=1S/C20H25N3S/c1-21-13-15-22(16-14-21)11-6-12-23-17-7-2-4-9-19(17)24-20-10-5-3-8-18(20)23/h2-5,7-10H,6,11-16H2,1H3
inchikey: WEYVCQFUGFRXOM-UHFFFAOYSA-N
mass: 339.49800
monoisotopicmass: 339.17692
smiles: CN1CCN(CCCN2c3ccccc3Sc3ccccc23)CC1
database cross reference: Beilstein:39009
database cross reference: CAS:84-97-9
database cross reference: Drug_Central:2100
database cross reference: Gmelin:298041
database cross reference: KEGG:C16903
database cross reference: PMID:1650428
database cross reference: PMID:19904008
database cross reference: PMID:23479940
database cross reference: PMID:24425538
database cross reference: Patent:GB780193
database cross reference: Reaxys:39009
database cross reference: Wikipedia:Perazine
has exact synonym: 10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
has_obo_namespace: chebi_ontology
has_related_synonym: 10-(3-(4-Methyl-1-piperazinyl)propyl)-10H-phenothiazine
has_related_synonym: N-(3-(4-Methyl-1-piperazinyl)propyl)phenothiazine
has_related_synonym: N-Methyl-piperazinyl-N'-propyl-phenothiazin
has_related_synonym: N-Methyl-piperazinylpropyl-phenothiazine
has_related_synonym: Pernazine
id: CHEBI:59118
in subset: 3 STAR

chemical substance
type: Class
subclass of: chemical entity
definition: A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Chemische Substanz
id: CHEBI:59999
in subset: 3 STAR

mixture
type: Class
subclass of: chemical substance
definition: A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: Mischung
id: CHEBI:60004
in subset: 3 STAR

polymer
type: Class
subclass of: mixture
definition: A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc..
imported from: chebi.owl
database cross reference: Wikipedia:Polymer
has exact synonym: Polymer
has_obo_namespace: chebi_ontology
has_related_synonym: Kunststoff
id: CHEBI:60027
in subset: 3 STAR

phosphatidylinositol trisphosphate
type: Class
subclass of: ester
definition: A derivative of phosphatidylinositol in which the inositol ring is phosphorylated at three unspecified positions.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: phosphatidylinositol trisphosphates
id: CHEBI:60169
in subset: 3 STAR

amyloid fibril
type: Class
subclass of: protein
definition: Insoluble fibrous protein aggregates exhibiting beta sheet structure.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:60425
in subset: 3 STAR

NMDA receptor antagonist
type: Class
subclass of: antagonist
definition: Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
imported from: chebi.owl
has_alternative_id: CHEBI:60797
has_obo_namespace: chebi_ontology
has_related_synonym: N-methyl-D-aspartate receptor antagonist
has_related_synonym: N-methyl-D-aspartate receptor antagonists
has_related_synonym: NMDA receptor antagonists
has_related_synonym: NMDAR antagonist
has_related_synonym: NMDAR antagonists
id: CHEBI:60643
in subset: 3 STAR

racemate
type: Class
subclass of: mixture
definition: A racemate is an equimolar mixture of a pair of enantiomers.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: melange racemique
has_related_synonym: racemates
has_related_synonym: racemic mixture
id: CHEBI:60911
in subset: 3 STAR

purine nucleoside bisphosphate
type: Class
subclass of: purines
subclass of: nucleoside bisphosphate
definition: A nucleoside bisphosphate that has a purine nucleobase.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: purine nucleoside bisphosphates
id: CHEBI:61078
in subset: 3 STAR

ribonucleoside bisphosphate
type: Class
subclass of: nucleoside bisphosphate
definition: A nucleoside bisphosphate where sugar of the nucleoside is ribose.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: ribonucleoside bisphosphates
id: CHEBI:61079
in subset: 3 STAR

nucleobase-containing molecular entity
type: Class
subclass of: heteroarene
subclass of: nitrogen molecular entity
definition: Any compound that has a nucleobase as a part.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: nucleobase-containing compound
has_related_synonym: nucleobase-containing compounds
has_related_synonym: nucleobase-containing molecular entities
id: CHEBI:61120
in subset: 3 STAR

ketoprofen
type: Class
subclass of: ketone
definition: An oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2.
imported from: chebi.owl
charge: 0
formula: C16H14O3
inchi: InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
inchikey: DKYWVDODHFEZIM-UHFFFAOYSA-N
mass: 254.28056
monoisotopicmass: 254.09429
smiles: CC(C(O)=O)c1cccc(c1)C(=O)c1ccccc1
database cross reference: CAS:22071-15-4
database cross reference: DrugBank:DB01009
database cross reference: Drug_Central:1528
database cross reference: HMDB:HMDB0015144
database cross reference: KEGG:C01716
database cross reference: KEGG:D00132
database cross reference: LINCS:LSM-1955
database cross reference: PMID:11452775
database cross reference: PMID:12772856
database cross reference: PMID:18969772
database cross reference: Reaxys:2216071
database cross reference: Wikipedia:Ketoprofen
has exact synonym: 2-(3-benzoylphenyl)propanoic acid
has exact synonym: Ketoprofen
has_obo_namespace: chebi_ontology
has_related_synonym: 2-(3-Benzoylphenyl)propionic acid
has_related_synonym: 3-Benzoyl-alpha-methylbenzeneacetic acid
has_related_synonym: 3-Benzoylhydratropic acid
has_related_synonym: L'Acide (benzoyl-3-phenyl)-2-propionique
has_related_synonym: Orudis (TN)
has_related_synonym: m-Benzoylhydratropic acid
id: CHEBI:6128
in subset: 3 STAR

ketorolac
type: Class
subclass of: racemate
definition: A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
imported from: chebi.owl
charge: 0
formula: C15H13NO3
inchi: InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)
inchikey: OZWKMVRBQXNZKK-UHFFFAOYSA-N
mass: 255.269
monoisotopicmass: 255.08954
database cross reference: CAS:74103-06-3
database cross reference: DrugBank:DB00465
database cross reference: HMDB:HMDB0014608
database cross reference: KEGG:C07062
database cross reference: KEGG:D08104
database cross reference: PMID:10027870
database cross reference: PMID:10223774
database cross reference: PMID:10593468
database cross reference: PMID:17456651
database cross reference: PMID:19281996
database cross reference: PMID:22191998
database cross reference: PMID:23088994
database cross reference: PMID:23126437
database cross reference: PMID:23179562
database cross reference: PMID:23298250
database cross reference: PMID:23447046
database cross reference: PMID:23473380
database cross reference: PMID:23562034
database cross reference: PMID:23653032
database cross reference: PMID:23702435
database cross reference: PMID:24022643
database cross reference: PMID:24112670
database cross reference: PMID:28166217
database cross reference: PMID:9549656
database cross reference: Patent:BE856681
database cross reference: Patent:US4089969
database cross reference: Patent:US4347186
database cross reference: Reaxys:413572
database cross reference: Wikipedia:Ketorolac
has exact synonym: rac-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
has_related_synonym: (+-)-ketorolac
has_related_synonym: ketorolac
has_related_synonym: ketorolaco
has_related_synonym: ketorolacum
has_related_synonym: rac-ketorolac
id: CHEBI:6129
in subset: 3 STAR

adenyl nucleotide
type: Class
subclass of: purine nucleotide
definition: A nucleotide having adenine as the base.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: adenine nucleotide
id: CHEBI:61293
in subset: 3 STAR

adenyl ribonucleotide
type: Class
subclass of: purine ribonucleotide
subclass of: adenyl nucleotide
definition: A purine riboncleotide where adenine is the purine.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: adenine ribonucleotide
id: CHEBI:61296
in subset: 3 STAR

fatty acid derivative
type: Class
subclass of: lipid
definition: Any organic molecular entity derived from a fatty acid.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: FA derivative
has_related_synonym: FA derivatives
has_related_synonym: fatty acid derivatives
id: CHEBI:61697
in subset: 3 STAR

hydroxy fatty acyl-CoA
type: Class
subclass of: fatty acyl-CoA
subclass of: hydroxyacyl-CoA
definition: A fatty-acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any hydroxy fatty acid.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: hydroxy FA-CoA
has_related_synonym: hydroxy-FA-coenzyme A
has_related_synonym: hydroxy-fatty acyl-CoAs
has_related_synonym: hydroxy-fatty acyl-coenzyme A
id: CHEBI:61902
in subset: 3 STAR

nitric oxide synthase inhibitor
type: Class
subclass of: inhibitor
subclass of: chemical role
definition: An enzyme inhibitor that inhibits the action of nitric oxide synthase, EC 1.14.13.39.
imported from: chiro.owl
has_obo_namespace: chebi_ontology
has_related_synonym: EC 1.14.13.39 inhibitor
has_related_synonym: EC 1.14.13.39 inhibitors
has_related_synonym: NADPH-diaphorase inhibitor
has_related_synonym: NADPH-diaphorase inhibitors
has_related_synonym: NO synthase inhibitor
has_related_synonym: NO synthase inhibitors
has_related_synonym: endothelium-derived relaxation factor-forming enzyme inhibitor
has_related_synonym: endothelium-derived relaxation factor-forming enzyme inhibitors
has_related_synonym: endothelium-derived relaxing factor synthase inhibitor
has_related_synonym: endothelium-derived relaxing factor synthase inhibitors
has_related_synonym: nitric oxide synthase inhibitors
has_related_synonym: nitric oxide synthetase inhibitor
has_related_synonym: nitric oxide synthetase inhibitors
has_related_synonym: nitric-oxide synthetase inhibitor
has_related_synonym: nitric-oxide synthetase inhibitors
id: CHEBI:61908

hydroxyacyl-CoA
type: Class
subclass of: acyl-CoA
definition: An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any hydroxycarboxylic acid.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: hydroxyacyl-CoAs
has_related_synonym: hydroxyacyl-coenzyme A
id: CHEBI:62618
in subset: 3 STAR

carbohydrate derivative
type: Class
subclass of: carbohydrates and carbohydrate derivatives
definition: Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: carbohydrate derivatives
has_related_synonym: derivatised carbohydrate
has_related_synonym: derivatised carbohydrates
has_related_synonym: derivatized carbohydrate
has_related_synonym: derivatized carbohydrates
id: CHEBI:63299
in subset: 3 STAR

monosaccharide derivative
type: Class
subclass of: carbohydrate derivative
definition: A carbohydrate derivative that is formally obtained from a monosaccharide.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: monosaccharide derivatives
id: CHEBI:63367
in subset: 3 STAR

pentose derivative
type: Class
subclass of: monosaccharide derivative
definition: A monosaccharide derivative that is formally obtained from a pentose.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: pentose derivatives
id: CHEBI:63409
in subset: 3 STAR

pravastatin
type: Class
subclass of: organic hydroxy compound
subclass of: organic molecule
subclass of: statin
definition: A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
imported from: chebi.owl
charge: 0
formula: C23H36O7
inchi: InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1
inchikey: TUZYXOIXSAXUGO-PZAWKZKUSA-N
mass: 424.52770
monoisotopicmass: 424.24610
has_alternative_id: CHEBI:8360
database cross reference: CAS:81093-37-0
database cross reference: DrugBank:DB00175
database cross reference: Drug_Central:2239
database cross reference: HMDB:HMDB0005022
database cross reference: KEGG:C01844
database cross reference: KEGG:D08410
database cross reference: KNApSAcK:C00000565
database cross reference: LINCS:LSM-3347
database cross reference: PMID:21749370
database cross reference: PMID:21851379
database cross reference: PMID:25264019
database cross reference: Reaxys:4825538
database cross reference: Wikipedia:Pravastatin
has exact synonym: (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid
has_related_synonym: pravastatin
has_related_synonym: pravastatin acid
has_related_synonym: pravastatina
has_related_synonym: pravastatine
has_related_synonym: pravastatinum
id: CHEBI:63618
in subset: 3 STAR

rasagiline
type: Class
subclass of: organonitrogen compound
subclass of: organic molecule
definition: An indane that consists of 1-aminoindane bearing an N-propargyl substituent. A selective, irreversible monoamine oxidase-B inhibitor.
imported from: chebi.owl
charge: 0
formula: C12H13N
inchi: InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1
inchikey: RUOKEQAAGRXIBM-GFCCVEGCSA-N
mass: 171.23830
monoisotopicmass: 171.10480
smiles: C#CCN[C@@H]1CCc2ccccc12
database cross reference: CAS:136236-51-6
database cross reference: DrugBank:DB01367
database cross reference: KEGG:D08469
database cross reference: PMID:20577110
database cross reference: PMID:21482191
database cross reference: PMID:21500280
database cross reference: PMID:21628600
database cross reference: PMID:21671840
database cross reference: PMID:21819487
database cross reference: PMID:21864207
database cross reference: PMID:21878836
database cross reference: PMID:21895884
database cross reference: PMID:21946113
database cross reference: PMID:21953831
database cross reference: PMID:21971006
database cross reference: PMID:21971007
database cross reference: PMID:22045282
database cross reference: PMID:22065207
database cross reference: Reaxys:9194207
database cross reference: Wikipedia:Rasagiline
has exact synonym: (1R)-N-(prop-2-yn-1-yl)indan-1-amine
has_obo_namespace: chebi_ontology
has_related_synonym: (1R)-N-propargylindan-1-amine
has_related_synonym: (R)-N-2-Propynyl-1-indanamine
has_related_synonym: (R)-indan-1-yl-prop-2-ynyl-amine
has_related_synonym: RAS
has_related_synonym: rasagiline
id: CHEBI:63620
in subset: 3 STAR

valdecoxib
type: Class
subclass of: organosulfur compound
definition: A member of the class of isoxazoles that is isoxazole which is substituted at positions 3, 4 and 5 by phenyl, p-sulfamoylphenyl and methyl groups, respectively. A selective cyclooxygenase 2-inhibitor, it used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of arthritis from 2001 until 2005, when it was withdrawn following concerns of an associated increased risk of heart attack and stroke.
imported from: chebi.owl
charge: 0
formula: C16H14N2O3S
inchi: InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20)
inchikey: LNPDTQAFDNKSHK-UHFFFAOYSA-N
mass: 314.35900
monoisotopicmass: 314.07251
smiles: Cc1onc(-c2ccccc2)c1-c1ccc(cc1)S(N)(=O)=O
has_alternative_id: CHEBI:41662
database cross reference: CAS:181695-72-7
database cross reference: DrugBank:DB00580
database cross reference: Drug_Central:2799
database cross reference: HMDB:HMDB0005033
database cross reference: KEGG:D02709
database cross reference: LINCS:LSM-5305
database cross reference: PDBeChem:COX
database cross reference: PMID:20467258
database cross reference: PMID:20717044
database cross reference: PMID:21073910
database cross reference: PMID:21720517
database cross reference: PMID:21769548
database cross reference: Reaxys:8563786
database cross reference: Wikipedia:Valdecoxib
has exact synonym: 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
has_obo_namespace: chebi_ontology
has_related_synonym: 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
has_related_synonym: Bextra
has_related_synonym: p-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
has_related_synonym: valdecoxib
has_related_synonym: valdecoxibum
id: CHEBI:63634
in subset: 3 STAR

exendin-4
type: Class
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
subclass of: polyatomic entity
definition: A bioactive polypeptide of 39 amino acid residues isolated from the saliva of the Gila monster (Heloderma suspectum). High-affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM); potently induces cAMP formation without stimulating amylase release in pancreatic acini; potentiates glucose-induced insulin secretion in isolated rat islets; protects against glutamate-induced neurotoxicity. A synthetic version is called exenatide.
imported from: chebi.owl
charge: 0
formula: C184H282N50O60S
inchikey: HTQBXNHDCUEHJF-URRANESESA-N
mass: 4186.57200
monoisotopicmass: 4184.02731
database cross reference: CAS:141758-74-9
database cross reference: KEGG:C15894
database cross reference: KEGG:D04121
database cross reference: PMID:12364473
database cross reference: PMID:1313797
database cross reference: PMID:14565957
database cross reference: PMID:16353670
database cross reference: PMID:17053883
database cross reference: PMID:20149450
database cross reference: PMID:20404826
database cross reference: PMID:22310470
database cross reference: PMID:22334721
database cross reference: PMID:22338110
database cross reference: PMID:22356440
database cross reference: PMID:22363635
database cross reference: PMID:22384126
database cross reference: Patent:EP1908778
database cross reference: Reaxys:9040649
database cross reference: Wikipedia:Exenatide
has exact synonym: L-histidylglycyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide
has exact synonym: exendin-4
has_obo_namespace: chebi_ontology
has_related_synonym: Ex4
has_related_synonym: Exendin 4
has_related_synonym: Heloderma suspectum gila monster exendin-4
has_related_synonym: His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
has_related_synonym: exenatida
has_related_synonym: exenatide
has_related_synonym: exenatidum
id: CHEBI:64073
in subset: 3 STAR

memantine
type: Class
subclass of: molecular pathway modifying agent therapy
definition: A primary aliphatic amine that is the 3,5-dimethyl derivative of 1-aminoadamantane. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
imported from: chebi.owl
charge: 0
formula: C12H21N
inchi: InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
inchikey: BUGYDGFZZOZRHP-UHFFFAOYSA-N
mass: 179.30180
monoisotopicmass: 179.16740
smiles: CC12CC3CC(C)(C1)CC(N)(C3)C2
has_alternative_id: CHEBI:34832
database cross reference: CAS:19982-08-2
database cross reference: DrugBank:DB01043
database cross reference: Drug_Central:1679
database cross reference: KEGG:C13736
database cross reference: KEGG:D08174
database cross reference: LINCS:LSM-5154
database cross reference: PMID:20104942
database cross reference: PMID:21953515
database cross reference: PMID:21955815
database cross reference: PMID:22030128
database cross reference: PMID:22134197
database cross reference: PMID:22245025
database cross reference: PMID:22248638
database cross reference: PMID:22290557
database cross reference: PMID:22297273
database cross reference: PMID:22300835
database cross reference: PMID:22311362
database cross reference: PMID:22327556
database cross reference: PMID:22329473
database cross reference: PMID:22392787
database cross reference: PMID:22414570
database cross reference: PMID:22425751
database cross reference: Patent:US2011282100
database cross reference: Reaxys:2075983
database cross reference: Wikipedia:Memantine
has exact synonym: 3,5-dimethyladamantan-1-amine
has_obo_namespace: chebi_ontology
has_related_synonym: 1,3-Dimethyl-5-adamantanamine
has_related_synonym: 1-Amino-3,5-dimethyladamantane
has_related_synonym: 3,5-Dimethyl-1-adamantanamine
has_related_synonym: 3,5-Dimethyl-1-aminoadamantane
has_related_synonym: 3,5-Dimethyltricyclo(3.3.1.1(3,7))decan-1-amine
has_related_synonym: memantina
has_related_synonym: memantine
has_related_synonym: memantinum
id: CHEBI:64312
in subset: 3 STAR

biaryl
type: Class
subclass of: organic aromatic compound
definition: An organic aromatic compound whose structure contains two aromatic rings or ring systems, joined to each other by a single bond.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: biaryls
id: CHEBI:64459
in subset: 3 STAR

phosphatidylcholine
type: Class
subclass of: ion
subclass of: organonitrogen compound
definition: A glycerophosphocholine that is glycero-3-phosphocholine bearing two acyl substituents at positions 1 and 2.
imported from: chebi.owl
charge: 0
formula: C10H18NO8PR2
mass: 311.226
monoisotopicmass: 311.07700
smiles: C[N+](C)(C)CCOP([O-])(=O)OCC(COC([*])=O)OC([*])=O
database cross reference: PMID:2474544
has exact synonym: 2,3-bis(acyloxy)propyl 2-(trimethylammonio)ethyl phosphate
has_obo_namespace: chebi_ontology
has_related_synonym: 1,2-diacyl-glycero-3-phosphocholine
has_related_synonym: a phosphatidylcholine (0)
id: CHEBI:64482
in subset: 3 STAR

sphingomyelin
type: Class
subclass of: ion
subclass of: organonitrogen compound
subclass of: ester
definition: Any of a class of phospholipids in which the amino group of a sphingoid base is in amide linkage with one of several fatty acids, while the terminal hydroxy group of the sphingoid base is esterified to phosphorylcholine.
imported from: chebi.owl
charge: 0
formula: C9H19N2O6PR2
mass: 282.23070
monoisotopicmass: 282.09807
smiles: C[N+](C)(C)CCOP([O-])(=O)OC[C@H](NC([*])=O)[C@H](O)[*]
database cross reference: LIPID_MAPS_class:LMSP0301
database cross reference: PMID:27242221
has_obo_namespace: chebi_ontology
has_related_synonym: Ceramide phosphocholine
has_related_synonym: an N-(acyl)-sphingosylphosphocholine
id: CHEBI:64583
in subset: 3 STAR

amyloid-beta
type: Class
subclass of: polypeptide
subclass of: chalcogen molecular entity
definition: A peptide of 36-43 amino acids that is processed from the amyloid precursor protein. Appears to be the main constituent of amyloid plaques (deposits found in the brains of Alzheimer's disease patients).
imported from: chebi.owl
relation: Alzpathway: APOE-AmyloidB leading to Unknown transportation; APOE-AmyloidB association. Source: https://pubmed.ncbi.nlm.nih.gov/33679311/
relation: Alzpathway: AmyloidB-CLU dissociation; AmyloidB-CLU association_Brain; AmyloidB-CLU leading to Unknown transportation. Source: https://pubmed.ncbi.nlm.nih.gov/30872998/
has_alternative_id: CHEBI:53002
database cross reference: KEGG:C16514
database cross reference: KEGG:C16515
database cross reference: PMID:21892760
database cross reference: PMID:22226401
database cross reference: PMID:22457725
database cross reference: PMID:22459190
database cross reference: PMID:22561032
database cross reference: PMID:22569063
database cross reference: Wikipedia:Beta_amyloid
has_obo_namespace: chebi_ontology
has_related_synonym: amyloid beta
has_related_synonym: beta amyloid
has_related_synonym: beta-amyloid
has_related_synonym: beta-amyloids
id: CHEBI:64645
in subset: 3 STAR

organic acid
type: Class
subclass of: organic molecular entity
definition: Any organic molecular entity that is acidic and contains carbon in covalent linkage.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic acids
id: CHEBI:64709
in subset: 3 STAR

lipoxin A4
type: Class
subclass of: hydroxy carboxylic acid
subclass of: fatty acid
definition: A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.
imported from: chebi.owl
charge: 0
formula: C20H32O5
inchi: InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
inchikey: IXAQOQZEOGMIQS-SSQFXEBMSA-N
mass: 352.46508
monoisotopicmass: 352.22497
smiles: CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H](O)[C@@H](O)CCCC(O)=O
database cross reference: HMDB:HMDB0004385
database cross reference: KEGG:C06314
database cross reference: LIPID_MAPS_instance:LMFA03040001
database cross reference: PMID:20435922
database cross reference: PMID:20802423
database cross reference: PMID:20833483
database cross reference: PMID:20950211
database cross reference: PMID:20959513
database cross reference: PMID:21263017
database cross reference: PMID:8690917
database cross reference: Reaxys:4698639
has exact synonym: (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyicosa-7,9,11,13-tetraenoic acid
has exact synonym: Lipoxin A4
has exact synonym: lipoxin A4
has_obo_namespace: chebi_ontology
has_related_synonym: (5S,6R,15S)-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
has_related_synonym: (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid
has_related_synonym: (5S,6R,7E,9E,11Z,13E,15S)-5,6,15-trihydroxyeicosa-7,9,11,13-tetraenoic acid
has_related_synonym: (7E,9E,11Z,13E)-(5S,6R,15S)-5,6,15-Trihydroxyicosa-7,9,11,13-tetraenoic acid
has_related_synonym: 5(S),6(R),15(S)-trihydroxyeicosa-7E,9E,11Z,13E-tetraenoic acid
has_related_synonym: 5S,6R,15S-Trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid
has_related_synonym: 5S,6R,15S-trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
has_related_synonym: 5S,6R-LipoxinA4
has_related_synonym: 6R-LXA4
has_related_synonym: LXA4
id: CHEBI:6498
in subset: 3 STAR

Loratadine
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
charge: 0
formula: C22H23ClN2O2
inchi: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
inchikey: JCCNYMKQOSZNPW-UHFFFAOYSA-N
mass: 382.884
monoisotopicmass: 382.14481
has_alternative_id: CHEBI:94763
database cross reference: CAS:79794-75-5
database cross reference: Drug_Central:1605
database cross reference: HMDB:HMDB0005000
database cross reference: KEGG:D00364
database cross reference: LINCS:LSM-5891
has exact synonym: Loratadine
has_obo_namespace: chebi_ontology
has_related_synonym: Claritin (TN)
has_related_synonym: claritin
has_related_synonym: loracert
has_related_synonym: loradex
has_related_synonym: loratidine
has_related_synonym: loratyne
id: CHEBI:6538
in subset: 2 STAR

Lorazepam
type: Class
subclass of: anxiolytic drug
imported from: chebi.owl
charge: 0
formula: C15H10Cl2N2O2
inchikey: DIWRORZWFLOCLC-UHFFFAOYSA-N
mass: 321.159
monoisotopicmass: 320.01193
has_alternative_id: CHEBI:94326
database cross reference: CAS:846-49-1
database cross reference: Drug_Central:1606
database cross reference: HMDB:HMDB0014332
database cross reference: KEGG:D00365
database cross reference: LINCS:LSM-4970
has exact synonym: Lorazepam
has_obo_namespace: chebi_ontology
has_related_synonym: Wy 4036
has_related_synonym: Wy-4036
has_related_synonym: ativan
id: CHEBI:6539
in subset: 2 STAR

Maprotiline
type: Class
subclass of: organic molecule
imported from: chebi.owl
charge: 0
formula: C20H23N
inchi: InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3
inchikey: QSLMDECMDJKHMQ-UHFFFAOYSA-N
mass: 277.404
monoisotopicmass: 277.18305
smiles: CNCCCC12CCC(c3ccccc13)c1ccccc21
database cross reference: CAS:10262-69-8
database cross reference: Drug_Central:1634
database cross reference: HMDB:HMDB0015069
database cross reference: KEGG:C07107
database cross reference: KEGG:D02566
database cross reference: LINCS:LSM-2043
has exact synonym: Maprotiline
has_obo_namespace: chebi_ontology
has_related_synonym: maprotiline HCl
has_related_synonym: maprotiline hydrochloride
id: CHEBI:6690
in subset: 2 STAR

folates
type: Class
subclass of: vitamin B9
subclass of: ion
definition: An N-acyl-L-alpha-amino acid anion obtained by deprotonation of any folic acid.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: folate
has_related_synonym: folate anion
has_related_synonym: folate anions
id: CHEBI:67011
in subset: 3 STAR

anti-inflammatory agent
type: Class
subclass of: application
definition: Any compound that has anti-inflammatory effects.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: anti-inflammatory agents
has_related_synonym: antiinflammatory agent
has_related_synonym: antiinflammatory agents
id: CHEBI:67079
in subset: 3 STAR

meclofenamic acid
type: Class
subclass of: organohalogen compound
subclass of: organonitrogen compound
definition: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
imported from: chebi.owl
charge: 0
formula: C14H11Cl2NO2
inchi: InChI=1S/C14H11Cl2NO2/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19/h2-7,17H,1H3,(H,18,19)
inchikey: SBDNJUWAMKYJOX-UHFFFAOYSA-N
mass: 296.14900
monoisotopicmass: 295.01668
smiles: Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
database cross reference: CAS:644-62-2
database cross reference: DrugBank:DB00939
database cross reference: Drug_Central:1650
database cross reference: HMDB:HMDB0015074
database cross reference: KEGG:C07117
database cross reference: KEGG:D02341
database cross reference: LINCS:LSM-3108
database cross reference: PDBeChem:JMS
database cross reference: PMID:15598972
database cross reference: PMID:16986603
database cross reference: PMID:17348907
database cross reference: PMID:1810521
database cross reference: PMID:19279153
database cross reference: PMID:21660425
database cross reference: PMID:23534549
database cross reference: PMID:23567745
database cross reference: PMID:23584353
database cross reference: PMID:322627
database cross reference: PMID:7349327
database cross reference: Patent:DE1149045
database cross reference: Patent:US3313848
database cross reference: Reaxys:2221428
database cross reference: Wikipedia:Meclofenamic_acid
has exact synonym: 2-[(2,6-dichloro-3-methylphenyl)amino]benzoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: CI-583
has_related_synonym: INF 4668
has_related_synonym: N-(2,6-dichloro-3-methylphenyl)anthranilic acid
has_related_synonym: N-(2,6-dichloro-m-tolyl)anthranilic acid
has_related_synonym: N-(3-methyl-2,6-dichlorophenyl)anthranilic acid
has_related_synonym: acide meclofenamique
has_related_synonym: acido meclofenamico
has_related_synonym: acidum meclofenamicum
has_related_synonym: meclofenamic acid
id: CHEBI:6710
in subset: 3 STAR

mefenamic acid
type: Class
subclass of: organonitrogen compound
definition: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
imported from: chebi.owl
charge: 0
formula: C15H15NO2
inchi: InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)
inchikey: HYYBABOKPJLUIN-UHFFFAOYSA-N
mass: 241.28510
monoisotopicmass: 241.11028
smiles: Cc1cccc(Nc2ccccc2C(O)=O)c1C
database cross reference: CAS:61-68-7
database cross reference: DrugBank:DB00784
database cross reference: Drug_Central:1663
database cross reference: HMDB:HMDB0014922
database cross reference: KEGG:C02168
database cross reference: KEGG:D00151
database cross reference: LINCS:LSM-4085
database cross reference: PDBeChem:ID8
database cross reference: PMID:14001132
database cross reference: PMID:17330662
database cross reference: PMID:22275128
database cross reference: PMID:22369458
database cross reference: PMID:23402341
database cross reference: PMID:23494912
database cross reference: PMID:23656341
database cross reference: PMID:2684858
database cross reference: PMID:28166217
database cross reference: PMID:3304401
database cross reference: PMID:4212650
database cross reference: PMID:425903
database cross reference: PMID:4916242
database cross reference: PMID:5286553
database cross reference: PMID:577447
database cross reference: PMID:6155061
database cross reference: Patent:BE605302
database cross reference: Patent:US3138636
database cross reference: Reaxys:2216243
database cross reference: Wikipedia:Mefenamic_acid
has exact synonym: 2-[(2,3-dimethylphenyl)amino]benzoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: CI-473
has_related_synonym: CN 35355
has_related_synonym: CN-35355
has_related_synonym: INF 3355
has_related_synonym: INF-3355
has_related_synonym: Mefenaminsaeure
has_related_synonym: N-(2,3-xylyl)-2-aminobenzoic acid
has_related_synonym: N-2,3-xylylanthranilic acid
has_related_synonym: Ponstel
has_related_synonym: acide mefenamique
has_related_synonym: acido mefenamico
has_related_synonym: acidum mefenamicum
has_related_synonym: mefenamic acid
id: CHEBI:6717
in subset: 3 STAR

meloxicam
type: Class
subclass of: organonitrogen compound
definition: A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.
imported from: chebi.owl
charge: 0
formula: C14H13N3O4S2
inchi: InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)
inchikey: ZRVUJXDFFKFLMG-UHFFFAOYSA-N
mass: 351.40100
monoisotopicmass: 351.03475
database cross reference: CAS:71125-38-7
database cross reference: DrugBank:DB00814
database cross reference: Drug_Central:1676
database cross reference: HMDB:HMDB0014952
database cross reference: KEGG:C08169
database cross reference: KEGG:D00969
database cross reference: PMID:10092958
database cross reference: PMID:12387696
database cross reference: PMID:16197363
database cross reference: PMID:16623613
database cross reference: PMID:16863437
database cross reference: PMID:18405470
database cross reference: PMID:19821429
database cross reference: PMID:23306395
database cross reference: PMID:23388116
database cross reference: PMID:23406022
database cross reference: PMID:24041211
database cross reference: PMID:24084190
database cross reference: PMID:28166217
database cross reference: PMID:8882380
database cross reference: PMID:9219316
database cross reference: Patent:DE2756113
database cross reference: Patent:US4233299
database cross reference: Reaxys:5886369
database cross reference: VSDB:1751
has exact synonym: 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
has_obo_namespace: chebi_ontology
has_related_synonym: Mobic
has_related_synonym: UNII-VG2QF83CGL
has_related_synonym: meloxicam
has_related_synonym: meloxicamum
id: CHEBI:6741
in subset: 3 STAR

mesoridazine
type: Class
subclass of: organosulfur compound
subclass of: organonitrogen compound
subclass of: phenothiazines
definition: A phenothiazine substituted at position 2 (para to the S atom) by a methylsulfinyl group, and on the nitrogen by a 2-(1-methylpiperidin-2-yl)ethyl group.
imported from: chebi.owl
charge: 0
formula: C21H26N2OS2
inchi: InChI=1S/C21H26N2OS2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
inchikey: SLVMESMUVMCQIY-UHFFFAOYSA-N
mass: 386.57400
monoisotopicmass: 386.14866
smiles: CN1CCCCC1CCN1c2ccccc2Sc2ccc(cc12)S(C)=O
has_alternative_id: CHEBI:248004
database cross reference: CAS:5588-33-0
database cross reference: DrugBank:DB00933
database cross reference: Drug_Central:1712
database cross reference: KEGG:C07143
database cross reference: KEGG:D02671
database cross reference: LINCS:LSM-1329
database cross reference: Patent:US3084161
database cross reference: Reaxys:1033986
database cross reference: Wikipedia:Mesoridazine
has exact synonym: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfinyl)-10H-phenothiazine
has exact synonym: Mesoridazine
has_obo_namespace: chebi_ontology
has_related_synonym: 10-(2(1-Methyl-2-piperidyl)ethyl)-2-(methylsulfinyl)phenothiazine
has_related_synonym: 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylsulfinyl phenothiazine
has_related_synonym: 2-Methanesulfinyl-10-[2-(1-methyl-piperidin-2-yl)-ethyl]-10H-phenothiazine
has_related_synonym: TPS-23
has_related_synonym: mesoridazina
has_related_synonym: mesoridazine
has_related_synonym: mesoridazinum
has_related_synonym: thioridazine thiomethyl sulfoxide
has_related_synonym: thioridazine-2-sulfoxide
id: CHEBI:6780
in subset: 3 STAR

methotrimeprazine
type: Class
subclass of: organonitrogen compound
subclass of: phenothiazines
definition: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.
imported from: chebi.owl
charge: 0
formula: C19H24N2OS
inchi: InChI=1S/C19H24N2OS/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21/h5-11,14H,12-13H2,1-4H3/t14-/m1/s1
inchikey: VRQVVMDWGGWHTJ-CQSZACIVSA-N
mass: 328.47274
monoisotopicmass: 328.16093
smiles: COc1ccc2Sc3ccccc3N(C[C@H](C)CN(C)C)c2c1
database cross reference: Beilstein:92434
database cross reference: CAS:60-99-1
database cross reference: DrugBank:DB01403
database cross reference: Drug_Central:1752
database cross reference: HMDB:HMDB0015474
database cross reference: KEGG:C07192
database cross reference: KEGG:D00403
database cross reference: KEGG:D06474
database cross reference: LINCS:LSM-2778
database cross reference: PMID:11026079
database cross reference: PMID:11260766
database cross reference: PMID:15700129
database cross reference: PMID:20825390
database cross reference: Patent:US2837518
database cross reference: Reaxys:92434
database cross reference: Wikipedia:Levomepromazine
has exact synonym: (2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
has exact synonym: Methotrimeprazine
has_obo_namespace: chebi_ontology
has_related_synonym: (-)-(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
has_related_synonym: (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine
has_related_synonym: 2-Methoxytrimeprazine
has_related_synonym: Levomepromazine
has_related_synonym: levomepromazina
has_related_synonym: levomepromazine
has_related_synonym: levomepromazinum
id: CHEBI:6838
in subset: 3 STAR

trichlorfon
type: Class
subclass of: organohalogen compound
subclass of: organophosphorus compound
subclass of: ester
definition: A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.
imported from: chebi.owl
charge: 0
formula: C4H8Cl3O4P
inchi: InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3
inchikey: NFACJZMKEDPNKN-UHFFFAOYSA-N
mass: 257.43700
monoisotopicmass: 255.92258
smiles: COP(=O)(OC)C(O)C(Cl)(Cl)Cl
database cross reference: Beilstein:1709434
database cross reference: CAS:52-68-6
database cross reference: Drug_Central:1787
database cross reference: KEGG:C07971
database cross reference: KEGG:D00805
database cross reference: LINCS:LSM-4995
database cross reference: PMID:19775726
database cross reference: PMID:24122545
database cross reference: PPDB:657
database cross reference: Reaxys:1709434
database cross reference: VSDB:657
database cross reference: Wikipedia:Metrifonate
has exact synonym: Trichlorfon
has exact synonym: dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-Trichlorfon
has_related_synonym: 1-Hydroxy-2,2,2-trichloroethylphosphonic acid dimethyl ester
has_related_synonym: Chlorophos
has_related_synonym: Methyl chlorophos
has_related_synonym: Metrifonate
has_related_synonym: metrifonate
has_related_synonym: metrifonato
has_related_synonym: metrifonatum
id: CHEBI:6908
in subset: 3 STAR

mirtazapine
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
charge: 0
formula: C17H19N3
inchi: InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
inchikey: RONZAEMNMFQXRA-UHFFFAOYSA-N
mass: 265.35290
monoisotopicmass: 265.15790
smiles: CN1CCN2C(C1)c1ccccc1Cc1cccnc21
database cross reference: Beilstein:549345
database cross reference: CAS:61337-67-5
database cross reference: DrugBank:DB00370
database cross reference: Drug_Central:1816
database cross reference: KEGG:C07570
database cross reference: KEGG:D00563
database cross reference: LINCS:LSM-1706
database cross reference: PMID:10446735
database cross reference: PMID:10653218
database cross reference: PMID:16965209
database cross reference: PMID:18548827
database cross reference: PMID:33163376
database cross reference: PMID:33422759
database cross reference: PMID:33559900
database cross reference: PMID:33685359
database cross reference: PMID:33841403
database cross reference: PMID:33856954
database cross reference: Patent:DE2614406
database cross reference: Patent:US4062848
database cross reference: VSDB:2980
database cross reference: Wikipedia:Mirtazapine
has exact synonym: 2-methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
has exact synonym: Mirtazapine
has_obo_namespace: chebi_ontology
has_related_synonym: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine
has_related_synonym: mirtazapina
has_related_synonym: mirtazapine
has_related_synonym: mirtazapinum
id: CHEBI:6950
in subset: 3 STAR

Moexipril
type: Class
subclass of: organonitrogen compound
imported from: chebi.owl
charge: 0
formula: C27H34N2O7
inchi: InChI=1S/C27H34N2O7/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32)/t17-,21-,22-/m0/s1
inchikey: UWWDHYUMIORJTA-HSQYWUDLSA-N
mass: 498.569
monoisotopicmass: 498.23660
database cross reference: CAS:103775-10-6
database cross reference: Drug_Central:1827
database cross reference: HMDB:HMDB0014829
database cross reference: KEGG:C07704
database cross reference: KEGG:D08225
database cross reference: LINCS:LSM-2751
has exact synonym: Moexipril
has_obo_namespace: chebi_ontology
has_related_synonym: moclobenid
has_related_synonym: moexipril HCl
has_related_synonym: moexipril hydrochloride
id: CHEBI:6960
in subset: 2 STAR

liraglutide
type: Class
subclass of: polypeptide
definition: A lipopeptide that is an analogue of human GLP-1 in which the lysine residue at position 27 is replaced by arginine and a hexadecanoyl group attached to the remaining lysine via a glutamic acid spacer. Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
imported from: chebi.owl
charge: 0
formula: C172H265N43O51
inchikey: YSDQQAXHVYUZIW-QCIJIYAXSA-N
mass: 3751.20200
monoisotopicmass: 3748.94646
database cross reference: CAS:204656-20-2
database cross reference: DrugBank:DB06655
database cross reference: Drug_Central:4164
database cross reference: KEGG:D06404
database cross reference: PMID:21964769
database cross reference: PMID:22038829
database cross reference: PMID:22051096
database cross reference: PMID:22245694
database cross reference: PMID:22338093
database cross reference: PMID:22382611
database cross reference: PMID:22405264
database cross reference: PMID:22443187
database cross reference: PMID:22446097
database cross reference: PMID:22536087
database cross reference: PMID:22569791
database cross reference: PMID:22587909
database cross reference: PMID:22592020
database cross reference: PMID:22727533
database cross reference: PMID:22846777
database cross reference: PMID:22851600
database cross reference: PMID:22862847
database cross reference: PMID:22927782
database cross reference: PMID:22938097
database cross reference: PMID:22958381
database cross reference: PMID:22973968
database cross reference: PMID:22985213
database cross reference: PMID:23068961
database cross reference: PMID:23082308
database cross reference: PMID:23149376
database cross reference: Patent:US2006160736
database cross reference: Patent:WO2008011518
database cross reference: Reaxys:10331362
database cross reference: Wikipedia:Liraglutide
has exact synonym: N2()-(L-histidyl-L-alanyl-L-alpha-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-alpha-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl)-N(6)-(N-hexadecanoyl-L-gamma-glutamyl)-L-lysyl-L-alpha-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine
has_obo_namespace: chebi_ontology
has_related_synonym: NN 2211
has_related_synonym: NN-2211
has_related_synonym: NN2211
has_related_synonym: Victoza
has_related_synonym: liraglutida
has_related_synonym: liraglutide
has_related_synonym: liraglutidum
id: CHEBI:71193
in subset: 3 STAR

tolmetin
type: Class
subclass of: ketone
definition: A monocarboxylic acid that is (1-methylpyrrol-2-yl)acetic acid substituted at position 5 on the pyrrole ring by a 4-methylbenzoyl group. Used in the form of its sodium salt dihydrate as a nonselective nonsteroidal anti-inflammatory drug.
imported from: chebi.owl
charge: 0
formula: C15H15NO3
inchi: InChI=1S/C15H15NO3/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18/h3-8H,9H2,1-2H3,(H,17,18)
inchikey: UPSPUYADGBWSHF-UHFFFAOYSA-N
mass: 257.28450
monoisotopicmass: 257.10519
smiles: Cc1ccc(cc1)C(=O)c1ccc(CC(O)=O)n1C
has_alternative_id: CHEBI:9618
database cross reference: CAS:26171-23-3
database cross reference: DrugBank:DB00500
database cross reference: Drug_Central:2699
database cross reference: HMDB:HMDB0014643
database cross reference: KEGG:C07149
database cross reference: KEGG:D02355
database cross reference: LINCS:LSM-3852
database cross reference: PDBeChem:TLT
database cross reference: PMID:1206489
database cross reference: PMID:19181568
database cross reference: PMID:19505209
database cross reference: PMID:20529813
database cross reference: PMID:20582193
database cross reference: PMID:20853464
database cross reference: PMID:21936545
database cross reference: PMID:22005020
database cross reference: PMID:22943177
database cross reference: PMID:23333829
database cross reference: PMID:3390998
database cross reference: PMID:445955
database cross reference: PMID:6686452
database cross reference: PMID:8472518
database cross reference: Patent:DE2836902
database cross reference: Patent:MX2010012712
database cross reference: Patent:WO2004069782
database cross reference: Patent:WO2008017903
database cross reference: Patent:WO2009072139
database cross reference: Reaxys:485305
database cross reference: Wikipedia:Tolmetin
has exact synonym: [1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetic acid
has_obo_namespace: chebi_ontology
has_related_synonym: 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid
has_related_synonym: 1-Methyl-5-p-toluoylpyrrole-2-acetic acid
has_related_synonym: 5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid
has_related_synonym: tolmetin
has_related_synonym: tolmetina
has_related_synonym: tolmetine
has_related_synonym: tolmetino
has_related_synonym: tolmetinum
id: CHEBI:71941
in subset: 3 STAR

flavonoids
type: Class
subclass of: oxygen molecular entity
subclass of: organic molecular entity
definition: Any organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them.
imported from: chebi.owl
database cross reference: Wikipedia:Flavonoids
has_obo_namespace: chebi_ontology
has_related_synonym: flavonoid
id: CHEBI:72544
in subset: 3 STAR

organic molecule
type: Class
subclass of: molecule
subclass of: carbon group molecular entity
subclass of: organic molecular entity
definition: Any molecule that consists of at least one carbon atom as part of the electrically neutral entity.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic compound
has_related_synonym: organic compounds
has_related_synonym: organic molecules
id: CHEBI:72695
in subset: 3 STAR

lumiracoxib
type: Class
subclass of: organohalogen compound
subclass of: organonitrogen compound
definition: An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity.
imported from: chebi.owl
charge: 0
formula: C15H13ClFNO2
inchi: InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20)
inchikey: KHPKQFYUPIUARC-UHFFFAOYSA-N
mass: 293.72100
monoisotopicmass: 293.06188
smiles: Cc1ccc(Nc2c(F)cccc2Cl)c(CC(O)=O)c1
database cross reference: CAS:220991-20-8
database cross reference: DrugBank:DB01283
database cross reference: Drug_Central:1618
database cross reference: HMDB:HMDB0015403
database cross reference: KEGG:D03714
database cross reference: PDBeChem:LUR
database cross reference: PMID:14965322
database cross reference: PMID:15311562
database cross reference: PMID:15456339
database cross reference: PMID:17380211
database cross reference: PMID:19800190
database cross reference: PMID:21688392
database cross reference: PMID:22069133
database cross reference: PMID:22142375
database cross reference: PMID:22621454
database cross reference: PMID:22732767
database cross reference: Reaxys:9784107
database cross reference: Wikipedia:Lumiracoxib
has exact synonym: {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
has_obo_namespace: chebi_ontology
has_related_synonym: 2-((2-chloro-6-fluorophenyl)amino)-5-methylbenzeneacetic acid
has_related_synonym: COX 189
has_related_synonym: COX-189
has_related_synonym: COX189
has_related_synonym: Prexige
has_related_synonym: lumiracoxib
has_related_synonym: lumiracoxibum
id: CHEBI:73044
in subset: 3 STAR

PK-11195
type: Class
subclass of: organohalogen compound
subclass of: organonitrogen compound
subclass of: organic molecule
definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
imported from: chebi.owl
charge: 0
formula: C21H21ClN2O
inchi: InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
inchikey: RAVIZVQZGXBOQO-UHFFFAOYSA-N
mass: 352.85700
monoisotopicmass: 352.13424
smiles: CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
database cross reference: Beilstein:4264456
database cross reference: CAS:85532-75-8
database cross reference: LINCS:LSM-1532
database cross reference: PMID:22528948
database cross reference: PMID:23358477
database cross reference: PMID:23597562
database cross reference: PMID:23611861
database cross reference: Reaxys:4264456
database cross reference: Wikipedia:PK-11195
has exact synonym: N-sec-butyl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide
has_obo_namespace: chebi_ontology
has_related_synonym: 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
has_related_synonym: PK11195
has_related_synonym: RP 52028
id: CHEBI:73290
in subset: 3 STAR

nabumetone
type: Class
subclass of: ketone
subclass of: ether
definition: A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs.
imported from: chebi.owl
charge: 0
formula: C15H16O2
inchi: InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3
inchikey: BLXXJMDCKKHMKV-UHFFFAOYSA-N
mass: 228.28630
monoisotopicmass: 228.11503
smiles: COc1ccc2cc(CCC(C)=O)ccc2c1
database cross reference: Beilstein:2103472
database cross reference: CAS:42924-53-8
database cross reference: DrugBank:DB00461
database cross reference: Drug_Central:1863
database cross reference: HMDB:HMDB0014604
database cross reference: KEGG:D00425
database cross reference: LINCS:LSM-3453
database cross reference: PDBeChem:NBO
database cross reference: PMID:21532165
database cross reference: PMID:21650014
database cross reference: PMID:21674107
database cross reference: PMID:21898684
database cross reference: PMID:22028826
database cross reference: PMID:22298755
database cross reference: PMID:22381180
database cross reference: PMID:22605805
database cross reference: PMID:22977877
database cross reference: PMID:23020786
database cross reference: PMID:23129452
database cross reference: PMID:23132511
database cross reference: PMID:23225308
database cross reference: PMID:23584048
database cross reference: PMID:23781467
database cross reference: PMID:23781476
database cross reference: PMID:23806470
database cross reference: PMID:24074034
database cross reference: PMID:24083957
database cross reference: Reaxys:2103472
database cross reference: Wikipedia:Nabumetone
has_obo_namespace: chebi_ontology
has_related_synonym: 4-(6-Methoxy-2-naphthalenyl)-2-butanone
has_related_synonym: 4-(6-Methoxy-2-naphthyl)-2-butanone
has_related_synonym: Relafen
has_related_synonym: nabumetona
has_related_synonym: nabumetone
has_related_synonym: nabumetonum
id: CHEBI:7443
in subset: 3 STAR

naproxen
type: Class
subclass of: ether
definition: A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.
imported from: chebi.owl
charge: 0
formula: C14H14O3
inchi: InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
inchikey: CMWTZPSULFXXJA-VIFPVBQESA-N
mass: 230.25920
monoisotopicmass: 230.09429
smiles: COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O
has_alternative_id: CHEBI:603695
database cross reference: Beilstein:3591067
database cross reference: CAS:22204-53-1
database cross reference: DrugBank:DB00788
database cross reference: Drug_Central:1883
database cross reference: HMDB:HMDB0001923
database cross reference: KEGG:D00118
database cross reference: LINCS:LSM-5689
database cross reference: PMID:18044350
database cross reference: PMID:24478225
database cross reference: PMID:9784154
database cross reference: Patent:US3904682
database cross reference: Patent:US4009197
database cross reference: Wikipedia:Naproxen
has exact synonym: (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid
has exact synonym: Naproxen
has exact synonym: naproxen
has_obo_namespace: chebi_ontology
has_related_synonym: (+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
has_related_synonym: (+)-(S)-Naproxen
has_related_synonym: (+)-2-(6-Methoxy-2-naphthyl)propionic acid
has_related_synonym: (+)-2-(Methoxy-2-naphthyl)-propionic acid
has_related_synonym: (+)-2-(Methoxy-2-naphthyl)-propionsaeure
has_related_synonym: (+)-Naproxen
has_related_synonym: (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid
has_related_synonym: (S)-(+)-Naproxen
has_related_synonym: (S)-2-(6-Methoxy-2-naphthyl)propanoic acid
has_related_synonym: (S)-2-(6-Methoxy-2-naphthyl)propionic acid
has_related_synonym: (S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
has_related_synonym: (S)-Naproxen
has_related_synonym: naproxen
has_related_synonym: naproxene
has_related_synonym: naproxeno
has_related_synonym: naproxenum
id: CHEBI:7476
in subset: 3 STAR

naproxen sodium
type: Class
subclass of: alkali metal molecular entity
definition: An organic sodium salt consisting of equimolar amounts of naproxen(1-) anions and sodium anions.
imported from: chebi.owl
charge: 0
formula: C14H13NaO3
formula: C14H13O3.Na
inchi: InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
inchikey: CDBRNDSHEYLDJV-FVGYRXGTSA-M
mass: 252.24100
monoisotopicmass: 252.07624
smiles: [Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
database cross reference: Beilstein:6378035
database cross reference: CAS:26159-34-2
database cross reference: DrugBank:DB00788
database cross reference: KEGG:D00970
has exact synonym: sodium (2S)-2-(6-methoxy-2-naphthyl)propanoate
has_obo_namespace: chebi_ontology
has_related_synonym: (-)-Sodium (S)-6-methoxy-alpha-methyl-2-naphthaleneacetate
id: CHEBI:7477
in subset: 3 STAR

gamma-secretase inhibitor
type: Class
subclass of: enzyme inhibitor
subclass of: chemical role
definition: An enzyme inhibitor that inhibits the activity of gamma-secretase.
imported from: chiro.owl
database cross reference: Wikipedia:Gamma_secretase
has exact synonym: Gamma-secretase inhibitor
has_obo_namespace: chebi_ontology
has_related_synonym: Gamma-secretase inhibitors
has_related_synonym: gamma-secretase inhibitors
id: CHEBI:74925

nefazodone
type: Class
subclass of: organohalogen compound
subclass of: ether
subclass of: organonitrogen compound
imported from: chebi.owl
charge: 0
formula: C25H32ClN5O2
inchi: InChI=1S/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3
inchikey: VRBKIVRKKCLPHA-UHFFFAOYSA-N
mass: 470.00700
monoisotopicmass: 469.22445
database cross reference: Beilstein:4728403
database cross reference: CAS:83366-66-9
database cross reference: DrugBank:DB01149
database cross reference: Drug_Central:1890
database cross reference: KEGG:C07256
database cross reference: KEGG:D08257
database cross reference: LINCS:LSM-4031
database cross reference: Patent:US4338317
database cross reference: Wikipedia:Nefazodone
has exact synonym: 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
has exact synonym: Nefazodone
has exact synonym: nefazodone
has_obo_namespace: chebi_ontology
has_related_synonym: 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one
has_related_synonym: nefazodona
has_related_synonym: nefazodone
has_related_synonym: nefazodonum
id: CHEBI:7494
in subset: 3 STAR

neostigmine
type: Class
subclass of: ion
definition: A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
imported from: chebi.owl
charge: +1
formula: C12H19N2O2
inchi: InChI=1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1
inchikey: ALWKGYPQUAPLQC-UHFFFAOYSA-N
mass: 223.29150
monoisotopicmass: 223.14410
smiles: CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C
database cross reference: Beilstein:3615946
database cross reference: CAS:59-99-4
database cross reference: DrugBank:DB01400
database cross reference: Drug_Central:1897
database cross reference: HMDB:HMDB0015472
database cross reference: KEGG:C07258
database cross reference: KEGG:D08261
database cross reference: LINCS:LSM-5360
database cross reference: PMID:7200780
database cross reference: PMID:8584207
database cross reference: Reaxys:3615946
database cross reference: Wikipedia:Neostigmine
has exact synonym: 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium
has_obo_namespace: chebi_ontology
has_related_synonym: (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate
has_related_synonym: 3-Trimethylammoniumphenyl N,N-dimethylcarbamate
has_related_synonym: Eustigmin
has_related_synonym: Eustigmine
has_related_synonym: Prostigmine
has_related_synonym: Vagostigmine
has_related_synonym: m-Trimethylammoniumphenyldimethylcarbamate
id: CHEBI:7514
in subset: 3 STAR

nimodipine
type: Class
subclass of: ester
subclass of: organic molecule
definition: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
imported from: chebi.owl
charge: 0
formula: C21H26N2O7
inchi: InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
inchikey: UIAGMCDKSXEBJQ-UHFFFAOYSA-N
mass: 418.44030
monoisotopicmass: 418.17400
smiles: COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C
database cross reference: CAS:66085-59-4
database cross reference: DrugBank:DB00393
database cross reference: Drug_Central:1937
database cross reference: KEGG:C07267
database cross reference: KEGG:D00438
database cross reference: LINCS:LSM-1659
database cross reference: PMID:12137606
database cross reference: PMID:16180362
database cross reference: PMID:17110283
database cross reference: PMID:21869451
database cross reference: PMID:22262041
database cross reference: PMID:22300914
database cross reference: PMID:8519001
database cross reference: Patent:DE2117571
database cross reference: Patent:US3799934
database cross reference: Reaxys:459792
database cross reference: Wikipedia:Nimodipine
has exact synonym: 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
has exact synonym: Nimodipine
has_obo_namespace: chebi_ontology
has_related_synonym: 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester
has_related_synonym: BAY e 9736
has_related_synonym: Nimotop
has_related_synonym: Periplum
has_related_synonym: isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
has_related_synonym: isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
has_related_synonym: nimodipine
has_related_synonym: nimodipino
has_related_synonym: nimodipinum
id: CHEBI:7575
in subset: 3 STAR

aromatic ketone
type: Class
subclass of: ketone
definition: A ketone in which the carbonyl group is attached to an aromatic ring.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: aromatic ketones
has_related_synonym: aryl ketone
has_related_synonym: aryl ketones
id: CHEBI:76224
in subset: 3 STAR

nortriptyline
type: Class
subclass of: antidepressant
definition: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
imported from: chebi.owl
charge: 0
formula: C19H21N
inchi: InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3
inchikey: PHVGLTMQBUFIQQ-UHFFFAOYSA-N
mass: 263.37678
monoisotopicmass: 263.16740
smiles: CNCCC=C1c2ccccc2CCc2ccccc12
database cross reference: Beilstein:2216786
database cross reference: CAS:72-69-5
database cross reference: DrugBank:DB00540
database cross reference: Drug_Central:1971
database cross reference: HMDB:HMDB0014680
database cross reference: KEGG:C07274
database cross reference: KEGG:D08288
database cross reference: LINCS:LSM-4039
database cross reference: PDBeChem:21B
database cross reference: PMID:10379421
database cross reference: PMID:14561440
database cross reference: PMID:17071817
database cross reference: PMID:23280809
database cross reference: PMID:24037379
database cross reference: PMID:24368464
database cross reference: PMID:25224004
database cross reference: PMID:25480462
database cross reference: PMID:25569864
database cross reference: PMID:25592638
database cross reference: PMID:25683584
database cross reference: PMID:25707462
database cross reference: PMID:25749306
database cross reference: PMID:26086857
database cross reference: PMID:26453560
database cross reference: Patent:NL6408512
database cross reference: Patent:US3442949
database cross reference: Patent:US3922305
database cross reference: Reaxys:2216786
database cross reference: Wikipedia:Nortriptyline
has exact synonym: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine
has exact synonym: Nortriptyline
has_obo_namespace: chebi_ontology
has_related_synonym: 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Delta(5,gamma)-propylamine
has_related_synonym: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine
has_related_synonym: Ateben
has_related_synonym: Avantyl
has_related_synonym: Aventyl
has_related_synonym: Noritren
has_related_synonym: Psychostyl
has_related_synonym: Sensaval
has_related_synonym: demethylamitriptyline
has_related_synonym: desmethylamitriptyline
has_related_synonym: nortriptylina
has_related_synonym: nortriptyline
has_related_synonym: nortriptylinum
id: CHEBI:7640
in subset: 3 STAR

olanzapine
type: Class
subclass of: antipsychotic agent
definition: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
imported from: chebi.owl
charge: 0
formula: C17H20N4S
inchi: InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
inchikey: KVWDHTXUZHCGIO-UHFFFAOYSA-N
mass: 312.434
monoisotopicmass: 312.14087
database cross reference: CAS:132539-06-1
database cross reference: DrugBank:DB00334
database cross reference: Drug_Central:1982
database cross reference: KEGG:C07322
database cross reference: KEGG:D00454
database cross reference: PMID:18022155
database cross reference: PMID:18504690
database cross reference: PMID:18792627
database cross reference: Patent:EP454436
database cross reference: Patent:US5229382
database cross reference: Reaxys:7655141
database cross reference: Wikipedia:Olanzapine
has exact synonym: 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
has exact synonym: Olanzapine
has_obo_namespace: chebi_ontology
has_related_synonym: Zyprexa
has_related_synonym: olanzapina
has_related_synonym: olanzapine
has_related_synonym: olanzapinum
id: CHEBI:7735
in subset: 3 STAR

oxaprozin
type: Class
subclass of: carbon group molecular entity
definition: A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthritis and rheumatoid arthritis.
imported from: chebi.owl
charge: 0
formula: C18H15NO3
inchi: InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)
inchikey: OFPXSFXSNFPTHF-UHFFFAOYSA-N
mass: 293.31660
monoisotopicmass: 293.10519
smiles: OC(=O)CCc1nc(-c2ccccc2)c(o1)-c1ccccc1
database cross reference: CAS:21256-18-8
database cross reference: DrugBank:DB00991
database cross reference: Drug_Central:2013
database cross reference: HMDB:HMDB0015126
database cross reference: KEGG:C07356
database cross reference: KEGG:D00463
database cross reference: LINCS:LSM-2553
database cross reference: PMID:1603605
database cross reference: PMID:1617910
database cross reference: PMID:19338579
database cross reference: PMID:19672323
database cross reference: PMID:20206429
database cross reference: PMID:23865335
database cross reference: PMID:385873
database cross reference: PMID:6432657
database cross reference: PMID:6611288
database cross reference: PMID:6863578
database cross reference: PMID:9459947
database cross reference: Patent:FR2001036
database cross reference: Patent:GB1206403
database cross reference: Patent:US3578671
database cross reference: Patent:WO2007082542
database cross reference: Reaxys:1083168
database cross reference: Wikipedia:Oxaprozin
has exact synonym: 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: Danoprox
has_related_synonym: Daypro
has_related_synonym: Dayrun
has_related_synonym: Deflam
has_related_synonym: Duraprox
has_related_synonym: Walix
has_related_synonym: oxaprozin
has_related_synonym: oxaprozina
has_related_synonym: oxaprozine
has_related_synonym: oxaprozinum
id: CHEBI:7822
in subset: 3 STAR

oxazepam
type: Class
subclass of: anxiolytic drug
definition: A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
imported from: chebi.owl
charge: 0
formula: C15H11ClN2O2
inchi: InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19)
inchikey: ADIMAYPTOBDMTL-UHFFFAOYSA-N
mass: 286.71300
monoisotopicmass: 286.05091
smiles: OC1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O
database cross reference: CAS:604-75-1
database cross reference: DrugBank:DB00842
database cross reference: Drug_Central:2015
database cross reference: HMDB:HMDB0014980
database cross reference: KEGG:C07359
database cross reference: KEGG:D00464
database cross reference: PMID:17456431
database cross reference: PMID:9811432
database cross reference: Patent:CN1543961
database cross reference: Reaxys:754065
database cross reference: Wikipedia:Oxazepam
has exact synonym: 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
has exact synonym: Oxazepam
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-Oxazepam
has_related_synonym: (RS)-Oxazepam
has_related_synonym: Serax
has_related_synonym: Tazepam
id: CHEBI:7823
in subset: 3 STAR

food component
type: Class
subclass of: physiological role
definition: A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: dietary component
has_related_synonym: dietary components
has_related_synonym: food components
id: CHEBI:78295
in subset: 3 STAR

huperzine A
type: Class
subclass of: organonitrogen compound
definition: A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity.
imported from: chebi.owl
charge: 0
formula: C15H18N2O
inchi: InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1
inchikey: ZRJBHWIHUMBLCN-YQEJDHNASA-N
mass: 242.31620
monoisotopicmass: 242.14191
database cross reference: CAS:102518-79-6
database cross reference: DrugBank:DB04864
database cross reference: PMID:12895686
database cross reference: PMID:23306162
database cross reference: PMID:24129696
database cross reference: PMID:24190328
database cross reference: PMID:24299147
database cross reference: PMID:24332448
database cross reference: PMID:24639880
database cross reference: Reaxys:3592896
database cross reference: Wikipedia:Huperzine_A
has exact synonym: (5R,9R,11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
has_obo_namespace: chebi_ontology
has_related_synonym: (-)-huperazine A
has_related_synonym: (-)-selagine
has_related_synonym: selagine
id: CHEBI:78330
in subset: 3 STAR

carbohydrates and carbohydrate derivatives
type: Class
subclass of: organooxygen compound
definition: Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: carbohydrates and derivatives
has_related_synonym: carbohydrates and their derivatives
id: CHEBI:78616
in subset: 3 STAR

2,3-epoxysqualene
type: Class
subclass of: isoprenoid
subclass of: ether
definition: A squalene triterpenoid obtained by formal epoxidation across the 2,3 C=C bond of squalene.
imported from: chebi.owl
charge: 0
formula: C30H50O
inchi: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+
inchikey: QYIMSPSDBYKPPY-BANQPHDMSA-N
mass: 426.71740
monoisotopicmass: 426.38617
smiles: CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C=C(/C)CC\C=C(/C)CCC1OC1(C)C
database cross reference: CAS:7200-26-2
database cross reference: Reaxys:1627703
has exact synonym: 2,2-dimethyl-3-[(3E,7E,11E,15E)-3,7,12,16,20-pentamethylhenicosa-3,7,11,15,19-pentaen-1-yl]oxirane
has_obo_namespace: chebi_ontology
has_related_synonym: 2,3-Edsq
has_related_synonym: 2,3-Epoxy-2,3-dihydrosqualene
has_related_synonym: 2,3-Oxidosqualene
has_related_synonym: Squalene-2,3-epoxide
has_related_synonym: Squalene-2,3-oxide
id: CHEBI:78662
in subset: 3 STAR

paroxetine
type: Class
subclass of: antidepressant
definition: A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.
imported from: chebi.owl
charge: 0
formula: C19H20FNO3
inchi: InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
inchikey: AHOUBRCZNHFOSL-YOEHRIQHSA-N
mass: 329.36540
monoisotopicmass: 329.14272
database cross reference: Beilstein:7467879
database cross reference: CAS:61869-08-7
database cross reference: DrugBank:DB00715
database cross reference: Drug_Central:2068
database cross reference: KEGG:C07415
database cross reference: KEGG:D02362
database cross reference: LINCS:LSM-2843
database cross reference: PMID:11009210
database cross reference: PMID:11169163
database cross reference: PMID:11271409
database cross reference: PMID:11281965
database cross reference: PMID:11324355
database cross reference: PMID:11360029
database cross reference: PMID:11513198
database cross reference: PMID:11563413
database cross reference: PMID:11565622
database cross reference: PMID:11819027
database cross reference: PMID:11893234
database cross reference: PMID:11910269
database cross reference: PMID:12027788
database cross reference: PMID:12088162
database cross reference: PMID:12369443
database cross reference: PMID:12421645
database cross reference: PMID:12818234
database cross reference: PMID:12820211
database cross reference: PMID:12906023
database cross reference: PMID:12920419
database cross reference: PMID:14516531
database cross reference: PMID:14521492
database cross reference: PMID:14566196
database cross reference: PMID:14566200
database cross reference: PMID:14619895
database cross reference: PMID:14624192
database cross reference: PMID:14673053
database cross reference: PMID:14689334
database cross reference: PMID:14978354
database cross reference: PMID:15048901
database cross reference: PMID:15199661
database cross reference: PMID:15241233
database cross reference: PMID:15264994
database cross reference: PMID:15374134
database cross reference: PMID:15376524
database cross reference: PMID:15544025
database cross reference: PMID:15613191
database cross reference: PMID:15845695
database cross reference: PMID:15853570
database cross reference: PMID:15903129
database cross reference: PMID:15963219
database cross reference: PMID:15992089
database cross reference: PMID:16395417
database cross reference: PMID:16397315
database cross reference: PMID:16426087
database cross reference: PMID:16765127
database cross reference: PMID:16822276
database cross reference: PMID:16913391
database cross reference: PMID:17122538
database cross reference: PMID:17162096
database cross reference: PMID:17219219
database cross reference: PMID:17286545
database cross reference: PMID:17452166
database cross reference: PMID:17559097
database cross reference: PMID:17612590
database cross reference: PMID:17652957
database cross reference: PMID:17874333
database cross reference: PMID:18273418
database cross reference: PMID:18345955
database cross reference: PMID:18808757
database cross reference: PMID:18983224
database cross reference: PMID:19687003
database cross reference: PMID:19851065

Galanin
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
database cross reference: KEGG:C15901
has_obo_namespace: chebi_ontology
id: CHEBI:80161
in subset: 2 STAR

perindopril
type: Class
subclass of: organic molecule
definition: An alpha-amino acid ester that is the ethyl ester of N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvaline
imported from: chebi.owl
charge: 0
formula: C19H32N2O5
inchi: InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1
inchikey: IPVQLZZIHOAWMC-QXKUPLGCSA-N
mass: 368.46786
monoisotopicmass: 368.23112
database cross reference: CAS:82834-16-0
database cross reference: DrugBank:DB00790
database cross reference: Drug_Central:2108
database cross reference: HMDB:HMDB0014928
database cross reference: KEGG:C07706
database cross reference: KEGG:D03753
database cross reference: LINCS:LSM-4080
database cross reference: PMID:24291100
database cross reference: PMID:24324048
database cross reference: PMID:24357222
database cross reference: PMID:24511479
database cross reference: PMID:24515310
database cross reference: PMID:24554346
database cross reference: PMID:24590580
database cross reference: PMID:24602481
database cross reference: PMID:24664905
database cross reference: Reaxys:4300272
database cross reference: Wikipedia:Perindopril
has exact synonym: ethyl N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvalinate
has_obo_namespace: chebi_ontology
has_related_synonym: (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid
has_related_synonym: perindopril
has_related_synonym: perindoprilum
id: CHEBI:8024
in subset: 3 STAR

Glucagon-like peptide 1
type: Class
subclass of: carbon group molecular entity
imported from: chebi.owl
database cross reference: KEGG:C16048
has_obo_namespace: chebi_ontology
has_related_synonym: GLP-1
id: CHEBI:80270
in subset: 2 STAR

perphenazine
type: Class
subclass of: organohalogen compound
subclass of: phenothiazines
definition: A phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10.
imported from: chebi.owl
charge: 0
formula: C21H26ClN3OS
inchi: InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
inchikey: RGCVKNLCSQQDEP-UHFFFAOYSA-N
mass: 403.96946
monoisotopicmass: 403.14851
database cross reference: Beilstein:54730
database cross reference: CAS:58-39-9
database cross reference: DrugBank:DB00850
database cross reference: Drug_Central:2113
database cross reference: HMDB:HMDB0014988
database cross reference: KEGG:C07427
database cross reference: KEGG:D00503
database cross reference: LINCS:LSM-2224
database cross reference: PMID:14401911
database cross reference: PMID:15674907
database cross reference: PMID:1650428
database cross reference: PMID:26660173
database cross reference: PMID:27150024
database cross reference: Patent:US2766235
database cross reference: Patent:US2860138
database cross reference: Reaxys:54730
database cross reference: Wikipedia:Perphenazine
has exact synonym: 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol
has exact synonym: Perphenazine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-(4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol
has_related_synonym: 2-chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine
has_related_synonym: 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
has_related_synonym: 4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol
has_related_synonym: Chlorpiprazine
has_related_synonym: Perfenazine
has_related_synonym: Perphenazin
has_related_synonym: Trilafon
has_related_synonym: gamma-(4-(beta-hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine
has_related_synonym: perfenazina
has_related_synonym: perphenazine
has_related_synonym: perphenazinum
id: CHEBI:8028
in subset: 3 STAR

Phenelzine
type: Class
subclass of: organonitrogen compound
imported from: chebi.owl
charge: 0
formula: C8H12N2
inchi: InChI=1S/C8H12N2/c9-10-7-6-8-4-2-1-3-5-8/h1-5,10H,6-7,9H2
inchikey: RMUCZJUITONUFY-UHFFFAOYSA-N
mass: 136.195
monoisotopicmass: 136.10005
smiles: NNCCc1ccccc1
database cross reference: CAS:51-71-8
database cross reference: Drug_Central:2123
database cross reference: HMDB:HMDB0014918
database cross reference: KEGG:C07430
database cross reference: KEGG:D08349
database cross reference: LINCS:LSM-5928
has exact synonym: Phenelzine
has_obo_namespace: chebi_ontology
has_related_synonym: 1-hydrazino-2-phenylethane
has_related_synonym: 2-phenylethylhydrazine
has_related_synonym: phenalzine
has_related_synonym: phenelzine sulfate
has_related_synonym: phenethylhydrazine
id: CHEBI:8060
in subset: 2 STAR

pimozide
type: Class
subclass of: organohalogen compound
definition: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which one of the nitrogens is substituted by a piperidin-4-yl group, which in turn is substituted on the nitrogen by a 4,4-bis(p-fluorophenyl)butyl group.
imported from: chebi.owl
charge: 0
formula: C28H29F2N3O
inchi: InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
inchikey: YVUQSNJEYSNKRX-UHFFFAOYSA-N
mass: 461.54620
monoisotopicmass: 461.22787
database cross reference: Beilstein:729089
database cross reference: CAS:2062-78-4
database cross reference: DrugBank:DB01100
database cross reference: Drug_Central:2172
database cross reference: HMDB:HMDB0015232
database cross reference: KEGG:C07566
database cross reference: KEGG:D00560
database cross reference: LINCS:LSM-2001
database cross reference: Reaxys:729089
database cross reference: Wikipedia:Pimozide
has exact synonym: 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
has exact synonym: Pimozide
has exact synonym: pimozide
has_obo_namespace: chebi_ontology
has_related_synonym: Halomonth
has_related_synonym: Neoperidole
has_related_synonym: Opiran
has_related_synonym: Orap
has_related_synonym: pimozida
has_related_synonym: pimozide
has_related_synonym: pimozidum
id: CHEBI:8212
in subset: 3 STAR

pioglitazone
type: Class
subclass of: ether
definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
imported from: chebi.owl
charge: 0
formula: C19H20N2O3S
inchi: InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)
inchikey: HYAFETHFCAUJAY-UHFFFAOYSA-N
mass: 356.43978
monoisotopicmass: 356.11946
smiles: CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1
database cross reference: Beilstein:3595485
database cross reference: CAS:111025-46-8
database cross reference: Chemspider:4663
database cross reference: DrugBank:DB01132
database cross reference: Drug_Central:2179
database cross reference: HMDB:HMDB0015264
database cross reference: KEGG:C07675
database cross reference: KEGG:D08378
database cross reference: LINCS:LSM-1592
database cross reference: PMID:12879407
database cross reference: PMID:14522601
database cross reference: PMID:18215232
database cross reference: PMID:20797618
database cross reference: PMID:27842070
database cross reference: PMID:33798599
database cross reference: PMID:33864097
database cross reference: PMID:33983968
database cross reference: PMID:33995271
database cross reference: PMID:34006325
database cross reference: PMID:34009030
database cross reference: Patent:EP193256
database cross reference: Patent:US4687777
database cross reference: Reaxys:3595485
database cross reference: Wikipedia:Pioglitazone
has exact synonym: 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
has exact synonym: Pioglitazone
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
has_related_synonym: pioglitazona
has_related_synonym: pioglitazone
has_related_synonym: pioglitazonum
id: CHEBI:8228
in subset: 3 STAR

piroxicam
type: Class
subclass of: organonitrogen compound
definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
imported from: chebi.owl
charge: 0
formula: C15H13N3O4S
inchi: InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)
inchikey: QYSPLQLAKJAUJT-UHFFFAOYSA-N
mass: 331.34600
monoisotopicmass: 331.06268
database cross reference: Beilstein:627692
database cross reference: CAS:36322-90-4
database cross reference: DrugBank:DB00554
database cross reference: Drug_Central:2210
database cross reference: HMDB:HMDB0014694
database cross reference: KEGG:C01608
database cross reference: KEGG:D00127
database cross reference: PMID:11142413
database cross reference: PMID:12154043
database cross reference: PMID:28166217
database cross reference: Patent:DE1943265
database cross reference: Patent:US3591584
database cross reference: Reaxys:627692
database cross reference: Wikipedia:Piroxicam
has exact synonym: 4-hydroxy-2-methyl-N-pyridin-2-yl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
has exact synonym: Piroxicam
has_obo_namespace: chebi_ontology
has_related_synonym: 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid
has_related_synonym: FELDENE
has_related_synonym: Feldene
has_related_synonym: Pyroxycam
has_related_synonym: piroxicam
has_related_synonym: piroxicamum
id: CHEBI:8249
in subset: 3 STAR

suvorexant
type: Class
subclass of: molecular pathway modifying agent therapy
definition: An aromatic amide obtained by formal condensation of the carboxy group of 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid with the secondary amino group of 5-chloro-2-[(5R)-5-methyl-1,4-diazepan-1-yl]-1,3-benzoxazole. An orexin receptor antagonist used for the management of insomnia.
imported from: chebi.owl
charge: 0
formula: C23H23ClN6O2
inchi: InChI=1S/C23H23ClN6O2/c1-15-3-5-20(30-25-8-9-26-30)18(13-15)22(31)29-12-11-28(10-7-16(29)2)23-27-19-14-17(24)4-6-21(19)32-23/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3/t16-/m1/s1
inchikey: JYTNQNCOQXFQPK-MRXNPFEDSA-N
mass: 450.92100
monoisotopicmass: 450.15710
smiles: C[C@@H]1CCN(CCN1C(=O)c1cc(C)ccc1-n1nccn1)c1nc2cc(Cl)ccc2o1
database cross reference: CAS:1030377-33-3
database cross reference: Drug_Central:4881
database cross reference: KEGG:D10082
database cross reference: PMID:23372274
database cross reference: PMID:23692283
database cross reference: PMID:24368893
database cross reference: PMID:24488306
database cross reference: PMID:24550770
database cross reference: PMID:24680372
database cross reference: PMID:24757363
database cross reference: PMID:25167596
database cross reference: PMID:25197807
database cross reference: PMID:25227290
database cross reference: PMID:25231363
database cross reference: PMID:25291725
database cross reference: PMID:25299902
database cross reference: Reaxys:18339082
database cross reference: Wikipedia:Suvorexant
has exact synonym: [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone
has_obo_namespace: chebi_ontology
has_related_synonym: BELSOMRA
has_related_synonym: MK 4305
has_related_synonym: MK-4305
has_related_synonym: MK4305
id: CHEBI:82698
in subset: 3 STAR

paliperidone
type: Class
subclass of: racemate
definition: A racemate comprising equimolar amounts of (R)- and (S)-paliperidone. Paliperidone is the primary active metabolite of the older antipsychotic risperidone and is used for treatment of schizophrenia.
imported from: chebi.owl
charge: 0
formula: C23H27FN4O3
mass: 426.48390
monoisotopicmass: 426.20672
database cross reference: CAS:144598-75-4
database cross reference: DrugBank:DB01267
database cross reference: HMDB:HMDB0015396
database cross reference: KEGG:D05339
database cross reference: PMID:23428785
database cross reference: PMID:24289141
database cross reference: PMID:24324228
database cross reference: PMID:24346811
database cross reference: PMID:24400982
database cross reference: PMID:24462396
database cross reference: PMID:24491033
database cross reference: PMID:24556260
database cross reference: PMID:24597755
database cross reference: PMID:24690136
database cross reference: PMID:24752928
database cross reference: PMID:24829608
database cross reference: PMID:24962437
database cross reference: PMID:25085446
database cross reference: PMID:25147315
database cross reference: PMID:25377151
database cross reference: Reaxys:8808385
database cross reference: Wikipedia:Paliperidone
has exact synonym: rac-3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-paliperidone
has_related_synonym: (RS)-paliperidone
has_related_synonym: 9-Hydroxyrisperidone
has_related_synonym: 9-OH-risperidone
has_related_synonym: 9-hydroxy-risperidone
has_related_synonym: Invega
has_related_synonym: R 76477
has_related_synonym: R-76477
has_related_synonym: RO76477
has_related_synonym: Ro-76477
has_related_synonym: paliperidone
has_related_synonym: rac-paliperidone
has_related_synonym: racemic paliperidone
id: CHEBI:82978
in subset: 3 STAR

moclobemide
type: Class
subclass of: organohalogen compound
subclass of: organonitrogen compound
definition: A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.
imported from: chebi.owl
charge: 0
formula: C13H17ClN2O2
inchi: InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)
inchikey: YHXISWVBGDMDLQ-UHFFFAOYSA-N
mass: 268.73900
monoisotopicmass: 268.09786
smiles: Clc1ccc(cc1)C(=O)NCCN1CCOCC1
database cross reference: CAS:71320-77-9
database cross reference: DrugBank:DB01171
database cross reference: Drug_Central:1825
database cross reference: HMDB:HMDB0015302
database cross reference: KEGG:D02561
database cross reference: LINCS:LSM-5247
database cross reference: PMID:23616181
database cross reference: PMID:24859491
database cross reference: PMID:24863864
database cross reference: PMID:25335956
database cross reference: Reaxys:530974
has exact synonym: 4-chloro-N-[2-(morpholin-4-yl)ethyl]benzamide
has_obo_namespace: chebi_ontology
has_related_synonym: moclobemida
has_related_synonym: moclobemide
has_related_synonym: moclobemidum
id: CHEBI:83531
in subset: 3 STAR

non-proteinogenic amino acid
type: Class
subclass of: organonitrogen compound
definition: Any amino-acid that is not naturally encoded in the genetic code of any organism.
imported from: chebi.owl
database cross reference: Wikipedia:Non-proteinogenic_amino_acids
has_obo_namespace: chebi_ontology
has_related_synonym: non-canonical amino acid
has_related_synonym: non-canonical amino acids
has_related_synonym: non-canonical amino-acid
has_related_synonym: non-canonical amino-acids
has_related_synonym: non-coded amino acid
has_related_synonym: non-coded amino acids
has_related_synonym: non-coded amino-acid
has_related_synonym: non-coded amino-acids
has_related_synonym: non-proteinogenic amino acids
has_related_synonym: non-proteinogenic amino-acid
has_related_synonym: non-proteinogenic amino-acids
id: CHEBI:83820
in subset: 3 STAR

pentose phosphate
type: Class
subclass of: phospho sugar
subclass of: pentose derivative
definition: Any phospho sugar that is the phosphate derivative of pentose.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
has_related_synonym: pentose phosphates
id: CHEBI:84055
in subset: 3 STAR

advanced glycation end-product
type: Class
subclass of: chalcogen molecular entity
definition: Carbohydrate derivatives resulting from the non-enzymatic glycosylation of proteins. They result in cells becoming stiffer and more prone to damage and premature aging.
imported from: chebi.owl
database cross reference: PMID:21116609
database cross reference: PMID:21659759
database cross reference: PMID:21909978
database cross reference: PMID:23129015
database cross reference: PMID:23404649
database cross reference: PMID:23745547
database cross reference: PMID:24173721
database cross reference: PMID:24370182
database cross reference: PMID:24624331
database cross reference: PMID:24771986
database cross reference: PMID:25172739
database cross reference: PMID:25438650
database cross reference: Wikipedia:Advanced_glycation_end-product
has_obo_namespace: chebi_ontology
has_related_synonym: AGE
has_related_synonym: AGEs
has_related_synonym: advanced glycation end-products
id: CHEBI:84123
in subset: 3 STAR

prochlorperazine
type: Class
subclass of: organohalogen compound
subclass of: organonitrogen compound
subclass of: phenothiazines
definition: A member of the class of phenothiazines that is 10H-phenothiazine having a chloro substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position.
imported from: chebi.owl
charge: 0
formula: C20H24ClN3S
inchi: InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3
inchikey: WIKYUJGCLQQFNW-UHFFFAOYSA-N
mass: 373.94300
monoisotopicmass: 373.13795
smiles: CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1
has_alternative_id: CHEBI:59073
database cross reference: Beilstein:48537
database cross reference: CAS:58-38-8
database cross reference: DrugBank:DB00433
database cross reference: Drug_Central:2274
database cross reference: HMDB:HMDB0014577
database cross reference: KEGG:C07403
database cross reference: KEGG:D00493
database cross reference: LINCS:LSM-2436
database cross reference: PMID:13808146
database cross reference: PMID:1650428
database cross reference: PMID:20825390
database cross reference: PMID:4891872
database cross reference: Patent:FR1167627
database cross reference: Patent:GB780193
database cross reference: Patent:US2902484
database cross reference: Reaxys:48537
database cross reference: Wikipedia:Prochlorperazine
has exact synonym: 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine
has exact synonym: Prochlorperazine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine
has_related_synonym: 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine
has_related_synonym: 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine
has_related_synonym: 3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine
has_related_synonym: Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine
has_related_synonym: N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine
has_related_synonym: Prochlorperazin
has_related_synonym: Prochlorpermazine
has_related_synonym: Prochlorpromazine
has_related_synonym: Procloperazine
has_related_synonym: prochlorperazine
has_related_synonym: prochlorperazinum
has_related_synonym: proclorperazina
id: CHEBI:8435
in subset: 3 STAR

promazine
type: Class
subclass of: organonitrogen compound
subclass of: phenothiazines
definition: A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.
imported from: chebi.owl
charge: 0
formula: C17H20N2S
inchi: InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3
inchikey: ZGUGWUXLJSTTMA-UHFFFAOYSA-N
mass: 284.42018
monoisotopicmass: 284.13472
smiles: CN(C)CCCN1c2ccccc2Sc2ccccc12
database cross reference: Beilstein:244925
database cross reference: CAS:58-40-2
database cross reference: DrugBank:DB00420
database cross reference: Drug_Central:2284
database cross reference: HMDB:HMDB0014564
database cross reference: KEGG:C07379
database cross reference: KEGG:D08430
database cross reference: LINCS:LSM-2137
database cross reference: PMID:1650428
database cross reference: PMID:18423639
database cross reference: PMID:19306624
database cross reference: PMID:20825390
database cross reference: Patent:US2519886
database cross reference: Reaxys:244925
database cross reference: Wikipedia:Promazine
has exact synonym: N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
has exact synonym: Promazine
has_obo_namespace: chebi_ontology
has_related_synonym: 10-(3-(Dimethylamino)propyl)phenothiazine
has_related_synonym: N-(3-Dimethylaminopropyl)phenothiazine
has_related_synonym: N-Dimethylamino-1-methylethyl thiodiphenylamine
has_related_synonym: promazina
has_related_synonym: promazine
has_related_synonym: promazinum
id: CHEBI:8459
in subset: 3 STAR

protriptyline
type: Class
subclass of: organic molecule
imported from: chebi.owl
charge: 0
formula: C19H21N
inchi: InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3
inchikey: BWPIARFWQZKAIA-UHFFFAOYSA-N
mass: 263.37678
monoisotopicmass: 263.16740
smiles: CNCCCC1c2ccccc2C=Cc2ccccc12
database cross reference: Beilstein:2217411
database cross reference: CAS:438-60-8
database cross reference: DrugBank:DB00344
database cross reference: Drug_Central:2320
database cross reference: KEGG:C07408
database cross reference: KEGG:D08447
database cross reference: LINCS:LSM-2936
database cross reference: Wikipedia:Protriptyline
has exact synonym: 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine
has exact synonym: Protriptyline
has_obo_namespace: chebi_ontology
has_related_synonym: 3-(5H-dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine
has_related_synonym: 5-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene
has_related_synonym: 7-(3-methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene
has_related_synonym: N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine
has_related_synonym: N-methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine
has_related_synonym: amimetilina
id: CHEBI:8597
in subset: 3 STAR

3-nitrotyrosine
type: Class
subclass of: organic hydroxy compound
subclass of: organic molecule
definition: A nitrotyrosine comprising tyrosine having a nitro group at the 3-position on the phenyl ring.
imported from: chebi.owl
charge: 0
formula: C9H10N2O5
inchi: InChI=1S/C9H10N2O5/c10-6(9(13)14)3-5-1-2-8(12)7(4-5)11(15)16/h1-2,4,6,12H,3,10H2,(H,13,14)
inchikey: FBTSQILOGYXGMD-UHFFFAOYSA-N
mass: 226.18610
monoisotopicmass: 226.05897
smiles: NC(Cc1ccc(O)c(c1)[N+]([O-])=O)C(O)=O
database cross reference: CAS:3604-79-3
database cross reference: Reaxys:2219127
has exact synonym: 3-nitrotyrosine
has_obo_namespace: chebi_ontology
id: CHEBI:86269
in subset: 3 STAR

Pyridostigmine
type: Class
subclass of: ion
imported from: chebi.owl
charge: +1
formula: C9H13N2O2
inchi: InChI=1S/C9H13N2O2/c1-10(2)9(12)13-8-5-4-6-11(3)7-8/h4-7H,1-3H3/q+1
inchikey: RVOLLAQWKVFTGE-UHFFFAOYSA-N
mass: 181.212
monoisotopicmass: 181.09715
smiles: CN(C)C(=O)Oc1ccc[n+](C)c1
database cross reference: CAS:155-97-5
database cross reference: Drug_Central:2330
database cross reference: HMDB:HMDB0014685
database cross reference: KEGG:C07410
database cross reference: LINCS:LSM-5770
has exact synonym: Pyridostigmine
has_obo_namespace: chebi_ontology
has_related_synonym: pyridostigmine bromide
has_related_synonym: pyridostigmine iodide
id: CHEBI:8665
in subset: 2 STAR

quetiapine
type: Class
subclass of: antipsychotic agent
imported from: chebi.owl
charge: 0
formula: C21H25N3O2S
inchi: InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2
inchikey: URKOMYMAXPYINW-UHFFFAOYSA-N
mass: 383.50700
monoisotopicmass: 383.16675
smiles: OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
database cross reference: CAS:111974-69-7
database cross reference: DrugBank:DB01224
database cross reference: Drug_Central:2337
database cross reference: KEGG:C07397
database cross reference: KEGG:D08456
database cross reference: LINCS:LSM-3543
database cross reference: Patent:EP240228
database cross reference: Patent:US4879288
database cross reference: Wikipedia:Quetiapine
has exact synonym: 2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol
has exact synonym: Quetiapine
has_obo_namespace: chebi_ontology
has_related_synonym: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol
has_related_synonym: quetiapina
has_related_synonym: quetiapine
has_related_synonym: quetiapinum
id: CHEBI:8707
in subset: 3 STAR

quinapril
type: Class
subclass of: organonitrogen compound
subclass of: organic molecule
definition: A member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure.
imported from: chebi.owl
charge: 0
formula: C25H30N2O5
inchi: InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1
inchikey: JSDRRTOADPPCHY-HSQYWUDLSA-N
mass: 438.517
monoisotopicmass: 438.21547
database cross reference: CAS:85441-61-8
database cross reference: DrugBank:DB00881
database cross reference: Drug_Central:2340
database cross reference: KEGG:C07398
database cross reference: KEGG:D03752
database cross reference: LINCS:LSM-3620
database cross reference: PMID:17404826
database cross reference: PMID:27165572
database cross reference: PMID:27169890
database cross reference: PMID:29980144
database cross reference: Patent:US4344949
database cross reference: Wikipedia:Quinapril
has exact synonym: (3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
has exact synonym: (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
has exact synonym: Quinapril
has_obo_namespace: chebi_ontology
has_related_synonym: (3S)-2-{N-[(2S)-1-ethoxycarbonyl-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
has_related_synonym: quinapril
has_related_synonym: quinaprilum
id: CHEBI:8713
in subset: 3 STAR

statin
type: Class
subclass of: carbon group molecular entity
definition: Any organooxygen compound whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties.
imported from: chebi.owl
database cross reference: PMID:1464741
database cross reference: PMID:15531285
database cross reference: PMID:20467214
database cross reference: PMID:25488134
database cross reference: PMID:25655639
database cross reference: PMID:25808421
database cross reference: PMID:25894795
database cross reference: PMID:26002574
database cross reference: Wikipedia:Statin
has_obo_namespace: chebi_ontology
has_related_synonym: statins
id: CHEBI:87631
in subset: 3 STAR

ramipril
type: Class
subclass of: organonitrogen compound
subclass of: organic molecule
definition: A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.
imported from: chebi.owl
charge: 0
formula: C23H32N2O5
inchi: InChI=1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1
inchikey: HDACQVRGBOVJII-JBDAPHQKSA-N
mass: 416.51060
monoisotopicmass: 416.23112
database cross reference: Beilstein:4214464
database cross reference: CAS:87333-19-5
database cross reference: DrugBank:DB00178
database cross reference: Drug_Central:2356
database cross reference: HMDB:HMDB0014324
database cross reference: KEGG:D00421
database cross reference: LINCS:LSM-5950
database cross reference: PMID:11095026
database cross reference: PMID:11575208
database cross reference: PMID:12076194
database cross reference: PMID:12768220
database cross reference: PMID:15110900
database cross reference: PMID:16144510
database cross reference: PMID:16734081
database cross reference: PMID:17004100
database cross reference: PMID:17192135
database cross reference: PMID:17496463
database cross reference: PMID:17903031
database cross reference: PMID:20122169
database cross reference: PMID:22799880
database cross reference: PMID:23557551
database cross reference: PMID:23713675
database cross reference: PMID:23747952
database cross reference: PMID:23842688
database cross reference: PMID:23842829
database cross reference: PMID:23951921
database cross reference: PMID:24048485
database cross reference: PMID:24090393
database cross reference: PMID:24191305
database cross reference: PMID:24397981
database cross reference: PMID:24435506
database cross reference: PMID:24452090
database cross reference: PMID:24509355
database cross reference: Reaxys:4214464
database cross reference: VSDB:1888
database cross reference: Wikipedia:Ramipril
has exact synonym: (2S,3aS,6aS)-1-[(2S)-2-{[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino}propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
has exact synonym: Ramipril
has_obo_namespace: chebi_ontology
has_related_synonym: (2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid
has_related_synonym: Altace (TN)
has_related_synonym: Ramiprilum
has_related_synonym: Tritace
has_related_synonym: ramipril
id: CHEBI:8774
in subset: 3 STAR

fructose 6-phosphate
type: Class
subclass of: organophosphorus compound
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: polyatomic entity
definition: A ketohexose monophosphate consisting of fructose having a phosphate group located at the 6-position.
imported from: chebi.owl
has_obo_namespace: chebi_ontology
id: CHEBI:88003
in subset: 3 STAR

risperidone
type: Class
subclass of: antipsychotic agent
definition: A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
imported from: chebi.owl
charge: 0
formula: C23H27FN4O2
inchi: InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
inchikey: RAPZEAPATHNIPO-UHFFFAOYSA-N
mass: 410.48450
monoisotopicmass: 410.21180
database cross reference: Beilstein:4891881
database cross reference: CAS:106266-06-2
database cross reference: DrugBank:DB00734
database cross reference: Drug_Central:2389
database cross reference: HMDB:HMDB0005020
database cross reference: KEGG:D00426
database cross reference: LINCS:LSM-3193
database cross reference: PMID:11229618
database cross reference: PMID:11476125
database cross reference: PMID:14687852
database cross reference: PMID:14728058
database cross reference: PMID:15096074
database cross reference: PMID:17054229
database cross reference: PMID:18545060
database cross reference: PMID:18722468
database cross reference: PMID:19412457
database cross reference: PMID:20825390
database cross reference: PMID:23327578
database cross reference: Patent:EP196132
database cross reference: Patent:US4804663
database cross reference: Reaxys:4891881
database cross reference: Wikipedia:Risperidone
has exact synonym: 3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
has exact synonym: risperidone
has_obo_namespace: chebi_ontology
has_related_synonym: Risperdal
has_related_synonym: Risperin
has_related_synonym: Rispolept
has_related_synonym: Rispolin
has_related_synonym: Sequinan
has_related_synonym: risperidona
has_related_synonym: risperidone
has_related_synonym: risperidonum
id: CHEBI:8871
in subset: 3 STAR

rivastigmine
type: Class
subclass of: cholinesterase inhibitor therapy
definition: A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.
imported from: chebi.owl
charge: 0
formula: C14H22N2O2
inchi: InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1
inchikey: XSVMFMHYUFZWBK-NSHDSACASA-N
mass: 250.33670
monoisotopicmass: 250.16813
smiles: CCN(C)C(=O)Oc1cccc(c1)[C@H](C)N(C)C
database cross reference: CAS:123441-03-2
database cross reference: DrugBank:DB00989
database cross reference: Drug_Central:2392
database cross reference: KEGG:C11766
database cross reference: KEGG:D03822
database cross reference: LINCS:LSM-5280
database cross reference: PMID:19032006
database cross reference: PMID:19370562
database cross reference: PMID:19392927
database cross reference: PMID:19619073
database cross reference: PMID:19893314
database cross reference: PMID:20070789
database cross reference: PMID:20370805
database cross reference: PMID:20865460
database cross reference: PMID:21131668
database cross reference: PMID:21246897
database cross reference: PMID:21977379
database cross reference: PMID:21996001
database cross reference: PMID:22009228
database cross reference: PMID:22010358
database cross reference: PMID:22044027
database cross reference: PMID:22054233
database cross reference: PMID:22068922
database cross reference: PMID:22087207
database cross reference: PMID:22163241
database cross reference: PMID:22163242
database cross reference: PMID:22163243
database cross reference: PMID:22173266
database cross reference: PMID:22195801
database cross reference: PMID:22224039
database cross reference: PMID:22230648
database cross reference: PMID:22230878
database cross reference: PMID:22290743
database cross reference: PMID:22362231
database cross reference: PMID:22409834
database cross reference: PMID:22451057
database cross reference: Patent:DE3805744
database cross reference: Patent:EP1980552
database cross reference: Patent:EP2233465
database cross reference: Patent:US2008255383
database cross reference: Patent:US2009298817
database cross reference: Patent:US5602176
database cross reference: Reaxys:7875788
database cross reference: Wikipedia:Rivastigmine
has exact synonym: 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
has_obo_namespace: chebi_ontology
has_related_synonym: (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
has_related_synonym: m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
has_related_synonym: rivastigmine
id: CHEBI:8874
in subset: 3 STAR

rofecoxib
type: Class
subclass of: organosulfur compound
definition: A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
imported from: chebi.owl
charge: 0
formula: C17H14O4S
inchi: InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
inchikey: RZJQGNCSTQAWON-UHFFFAOYSA-N
mass: 314.35600
monoisotopicmass: 314.06128
database cross reference: Beilstein:8269007
database cross reference: CAS:162011-90-7
database cross reference: DrugBank:DB00533
database cross reference: Drug_Central:2397
database cross reference: KEGG:C07590
database cross reference: KEGG:D00568
database cross reference: LINCS:LSM-2482
database cross reference: PMID:10859630
database cross reference: PMID:11014111
database cross reference: PMID:12069696
database cross reference: PMID:16934051
database cross reference: PMID:20162413
database cross reference: PMID:28166217
database cross reference: Reaxys:8269007
database cross reference: Wikipedia:Rofecoxib
has exact synonym: 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
has exact synonym: Rofecoxib
has_obo_namespace: chebi_ontology
has_related_synonym: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
has_related_synonym: 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
has_related_synonym: Ceoxx
has_related_synonym: Vioxx
has_related_synonym: rofecoxib
has_related_synonym: rofecoxibum
id: CHEBI:8887
in subset: 3 STAR

sertraline
type: Class
subclass of: organohalogen compound
subclass of: organonitrogen compound
subclass of: organic molecule
definition: A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.
imported from: chebi.owl
charge: 0
formula: C17H17Cl2N
inchi: InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1
inchikey: VGKDLMBJGBXTGI-SJCJKPOMSA-N
mass: 306.23000
monoisotopicmass: 305.07380
database cross reference: Beilstein:5753709
database cross reference: CAS:79617-96-2
database cross reference: DrugBank:DB01104
database cross reference: Drug_Central:2436
database cross reference: HMDB:HMDB0005010
database cross reference: KEGG:C07246
database cross reference: KEGG:D02360
database cross reference: LINCS:LSM-3843
database cross reference: PDBeChem:SRE
database cross reference: PMID:19502000
database cross reference: PMID:21823671
database cross reference: Patent:US4536518
database cross reference: Reaxys:5753709
database cross reference: Wikipedia:Sertraline
has exact synonym: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
has exact synonym: Sertraline
has_obo_namespace: chebi_ontology
has_related_synonym: (+)-sertraline
has_related_synonym: (1S,4S)-sertraline
has_related_synonym: (1S-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine
has_related_synonym: CP 51974
has_related_synonym: cis-(+)-sertraline
has_related_synonym: sertralina
has_related_synonym: sertraline
has_related_synonym: sertralinum
id: CHEBI:9123
in subset: 3 STAR

simvastatin
type: Class
subclass of: organic molecule
subclass of: statin
definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
imported from: chebi.owl
charge: 0
formula: C25H38O5
inchi: InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
inchikey: RYMZZMVNJRMUDD-HGQWONQESA-N
mass: 418.56620
monoisotopicmass: 418.27192
has_alternative_id: CHEBI:45577
database cross reference: Beilstein:4768037
database cross reference: CAS:79902-63-9
database cross reference: DrugBank:DB00641
database cross reference: Drug_Central:2445
database cross reference: HMDB:HMDB0005007
database cross reference: KEGG:D00434
database cross reference: LINCS:LSM-2492
database cross reference: PMID:11336576
database cross reference: PMID:12827636
database cross reference: PMID:14561068
database cross reference: PMID:14973129
database cross reference: PMID:18199328
database cross reference: PMID:18688862
database cross reference: PMID:18936176
database cross reference: Patent:EP33538
database cross reference: Patent:US4444784
database cross reference: Wikipedia:Simvastatin
has exact synonym: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
has exact synonym: Simvastatin
has_obo_namespace: chebi_ontology
has_related_synonym: 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
has_related_synonym: MK-733
has_related_synonym: Simvastatina
has_related_synonym: Simvastatine
has_related_synonym: Simvastatinum
has_related_synonym: Zocor
has_related_synonym: simvastatin
id: CHEBI:9150
in subset: 3 STAR

sulindac
type: Class
subclass of: organohalogen compound
subclass of: organosulfur compound
definition: A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
imported from: chebi.owl
charge: 0
formula: C20H17FO3S
inchi: InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
inchikey: MLKXDPUZXIRXEP-MFOYZWKCSA-N
mass: 356.41158
monoisotopicmass: 356.08824
smiles: CC1=C(CC(O)=O)c2cc(F)ccc2C\1=C/c1ccc(cc1)S(C)=O
database cross reference: Beilstein:2951842
database cross reference: CAS:38194-50-2
database cross reference: DrugBank:DB00605
database cross reference: Drug_Central:2534
database cross reference: HMDB:HMDB0014743
database cross reference: KEGG:C01531
database cross reference: KEGG:D00120
database cross reference: PDBeChem:SUZ
database cross reference: PMID:11569947
database cross reference: PMID:11927004
database cross reference: PMID:12406542
database cross reference: PMID:15020200
database cross reference: PMID:15123337
database cross reference: PMID:19884509
database cross reference: PMID:23689354
database cross reference: PMID:23804703
database cross reference: Patent:DE2039426
database cross reference: Patent:US3654349
database cross reference: Reaxys:2951842
database cross reference: Wikipedia:Sulindac
has exact synonym: Sulindac
has exact synonym: {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
has_related_synonym: Clinoril
has_related_synonym: Sulindacum
has_related_synonym: cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
has_related_synonym: cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid
has_related_synonym: sulindac
has_related_synonym: sulindaco
id: CHEBI:9352
in subset: 3 STAR

suprofen
type: Class
subclass of: ketone
definition: An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.
imported from: chebi.owl
charge: 0
formula: C14H12O3S
inchi: InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
inchikey: MDKGKXOCJGEUJW-UHFFFAOYSA-N
mass: 260.30800
monoisotopicmass: 260.05072
smiles: CC(C(O)=O)c1ccc(cc1)C(=O)c1cccs1
has_alternative_id: CHEBI:193117
database cross reference: Beilstein:1430606
database cross reference: CAS:40828-46-4
database cross reference: DrugBank:DB00870
database cross reference: Drug_Central:2546
database cross reference: KEGG:C07320
database cross reference: KEGG:D00452
database cross reference: LINCS:LSM-4406
database cross reference: PMID:11195850
database cross reference: PMID:11409928
database cross reference: PMID:14570769
database cross reference: PMID:14664336
database cross reference: PMID:27559371
database cross reference: PMID:7918773
database cross reference: PMID:8058269
database cross reference: Patent:DE2353357
database cross reference: Patent:US4035376
database cross reference: Reaxys:1430606
database cross reference: Wikipedia:Suprofen
has exact synonym: 2-[4-(thiophen-2-ylcarbonyl)phenyl]propanoic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-2-(p-(2-thenoyl)phenyl)propionic acid
has_related_synonym: 2-(4-(2-Thenoyl)phenyl)propionsaeure
has_related_synonym: 2-[4-(Thiophene-2-carbonyl)-phenyl]-propionic acid
has_related_synonym: 4-(2-Thenoyl)hydratropsaeure
has_related_synonym: PROFENAL
has_related_synonym: SUTOPROFEN
has_related_synonym: alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic acid
has_related_synonym: p-2-thenoylhydratropic acid
has_related_synonym: suprofen
has_related_synonym: suprofene
has_related_synonym: suprofenum
id: CHEBI:9362
in subset: 3 STAR

Temazepam
type: Class
subclass of: anxiolytic drug
imported from: chebi.owl
charge: 0
formula: C16H13ClN2O2
inchi: InChI=1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3
inchikey: SEQDDYPDSLOBDC-UHFFFAOYSA-N
mass: 300.740
monoisotopicmass: 300.06656
smiles: CN1c2ccc(Cl)cc2C(=NC(O)C1=O)c1ccccc1
database cross reference: CAS:846-50-4
database cross reference: Drug_Central:2585
database cross reference: HMDB:HMDB0014376
database cross reference: KEGG:C07125
database cross reference: KEGG:D00370
has exact synonym: Temazepam
has_obo_namespace: chebi_ontology
has_related_synonym: (RS)-Temazepam
has_related_synonym: Restoril (TN)
has_related_synonym: levanxene
has_related_synonym: levanxol
id: CHEBI:9435
in subset: 2 STAR

thioridazine
type: Class
subclass of: phenothiazines
definition: A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
imported from: chebi.owl
charge: 0
formula: C21H26N2S2
inchi: InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
inchikey: KLBQZWRITKRQQV-UHFFFAOYSA-N
mass: 370.57500
monoisotopicmass: 370.15374
smiles: CSc1ccc2Sc3ccccc3N(CCC3CCCCN3C)c2c1
database cross reference: Beilstein:94457
database cross reference: CAS:50-52-2
database cross reference: DrugBank:DB00679
database cross reference: Drug_Central:2637
database cross reference: HMDB:HMDB0014817
database cross reference: KEGG:D00373
database cross reference: LINCS:LSM-1863
database cross reference: PMID:10796547
database cross reference: PMID:11686961
database cross reference: PMID:1650428
database cross reference: PMID:17764469
database cross reference: PMID:17876580
database cross reference: PMID:19747949
database cross reference: PMID:20825390
database cross reference: PMID:26956010
database cross reference: PMID:27023487
database cross reference: PMID:27068340
database cross reference: PMID:9352572
database cross reference: Reaxys:94457
database cross reference: Wikipedia:Thioridazine
has exact synonym: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine
has_obo_namespace: chebi_ontology
has_related_synonym: 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine
has_related_synonym: 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine
has_related_synonym: 3-Methylmercapto-N-(2'-(N-methyl-2-piperidyl)ethyl)phenothiazine
has_related_synonym: Mallorol
has_related_synonym: Malloryl
has_related_synonym: Meleril
has_related_synonym: Mellaril
has_related_synonym: Mellaril-S
has_related_synonym: Mellerets
has_related_synonym: Mellerette
has_related_synonym: Melleril
has_related_synonym: Orsanil
has_related_synonym: Sonapax
has_related_synonym: Thioridazin
has_related_synonym: thioridazine
has_related_synonym: thioridazinum
has_related_synonym: tioridazina
id: CHEBI:9566
in subset: 3 STAR

trandolapril
type: Class
subclass of: organonitrogen compound
subclass of: organic molecule
definition: A heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension.
imported from: chebi.owl
charge: 0
formula: C24H34N2O5
inchi: InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1
inchikey: VXFJYXUZANRPDJ-WTNASJBWSA-N
mass: 430.545
monoisotopicmass: 430.24677
database cross reference: CAS:87679-37-6
database cross reference: Chemspider:4588590
database cross reference: DrugBank:DB00519
database cross reference: Drug_Central:2712
database cross reference: HMDB:HMDB0014660
database cross reference: KEGG:D00383
database cross reference: PMID:1648489
database cross reference: PMID:19337528
database cross reference: PMID:22247843
database cross reference: PMID:23784370
database cross reference: PMID:24835355
database cross reference: PMID:25802524
database cross reference: PMID:25864194
database cross reference: PMID:26915813
database cross reference: PMID:27215243
database cross reference: PMID:29319234
database cross reference: PMID:32964020
database cross reference: PMID:33660934
database cross reference: PMID:3383998
database cross reference: PMID:34172790
database cross reference: PMID:8515499
database cross reference: PMID:8515500
database cross reference: PMID:8515501
database cross reference: PMID:8515502
database cross reference: PMID:8515504
database cross reference: PMID:9770740
database cross reference: Patent:KR20080046630
database cross reference: Patent:WO2006014916
database cross reference: Reaxys:8655766
database cross reference: Wikipedia:Trandolapril
has exact synonym: (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid
has_obo_namespace: chebi_ontology
has_related_synonym: (2S,3aR,7aS)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester
has_related_synonym: Gopten
has_related_synonym: Mavik
has_related_synonym: Odrik
has_related_synonym: RU 44570
has_related_synonym: RU-44570
has_related_synonym: RU44570
has_related_synonym: trandolapril
has_related_synonym: trandolaprilum
id: CHEBI:9649
in subset: 3 STAR

tranylcypromine
type: Class
subclass of: racemate
definition: A racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
imported from: chebi.owl
has_alternative_id: CHEBI:39677
has_alternative_id: CHEBI:46075
database cross reference: CAS:155-09-9
database cross reference: DrugBank:DB00752
database cross reference: HMDB:HMDB0014890
database cross reference: KEGG:C07155
database cross reference: KEGG:D08625
database cross reference: MetaCyc:CPD-17677
database cross reference: PDBeChem:TPA
database cross reference: PMID:11181487
database cross reference: PMID:12495786
database cross reference: PMID:13948833
database cross reference: PMID:15049511
database cross reference: PMID:18974922
database cross reference: PMID:20148560
database cross reference: PMID:26257022
database cross reference: PMID:26302763
database cross reference: PMID:26348077
database cross reference: PMID:26479223
database cross reference: PMID:26748182
database cross reference: PMID:26917855
database cross reference: PMID:7236991
database cross reference: PMID:7511710
database cross reference: PMID:7531152
database cross reference: PMID:7675827
database cross reference: PMID:7776254
database cross reference: PMID:8831798
database cross reference: PMID:9049597
database cross reference: PMID:9829163
database cross reference: Reaxys:3195803
database cross reference: Wikipedia:Tranylcypromine
has exact synonym: Tranylcypromine
has exact synonym: rac-(1R,2S)-2-phenylcyclopropan-1-amine
has_obo_namespace: chebi_ontology
has_related_synonym: (+-)-trans-2-phenylcyclopropylamine
has_related_synonym: (1R*,2S*)-2-phenylcyclopropan-1-amine
has_related_synonym: DL-tranylcypromine
has_related_synonym: Racemic Tranylcypromine
has_related_synonym: SKF 385
has_related_synonym: SKF Trans-385
has_related_synonym: Transamine
has_related_synonym: Tranylcypromin
has_related_synonym: tranilcipromina
has_related_synonym: trans-2-phenylcyclopropylamine
has_related_synonym: trans-DL-2-Phenylcyclopropylamine
has_related_synonym: tranylcypromine
has_related_synonym: tranylcyprominum
id: CHEBI:9652
in subset: 3 STAR

trazodone
type: Class
subclass of: antidepressant
definition: An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
imported from: chebi.owl
charge: 0
formula: C19H22ClN5O
inchi: InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2
inchikey: PHLBKPHSAVXXEF-UHFFFAOYSA-N
mass: 371.86400
monoisotopicmass: 371.15129
database cross reference: Beilstein:628010
database cross reference: CAS:19794-93-5
database cross reference: DrugBank:DB00656
database cross reference: Drug_Central:2717
database cross reference: KEGG:C07156
database cross reference: KEGG:D08626
database cross reference: LINCS:LSM-3580
database cross reference: Patent:US3381009
database cross reference: Wikipedia:Trazodone
has exact synonym: 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
has exact synonym: Trazodone
has_obo_namespace: chebi_ontology
has_related_synonym: 2-(3-[4-(3-chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
has_related_synonym: trazodona
has_related_synonym: trazodone
has_related_synonym: trazodonum
id: CHEBI:9654
in subset: 3 STAR

triflupromazine
type: Class
subclass of: organohalogen compound
subclass of: organonitrogen compound
subclass of: phenothiazines
definition: A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(dimethylamino)propyl group at the N-10 position.
imported from: chebi.owl
charge: 0
formula: C18H19F3N2S
inchi: InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3
inchikey: XSCGXQMFQXDFCW-UHFFFAOYSA-N
mass: 352.41700
monoisotopicmass: 352.12210
smiles: CN(C)CCCN1c2ccccc2Sc2ccc(cc12)C(F)(F)F
database cross reference: Beilstein:335308
database cross reference: CAS:146-54-3
database cross reference: DrugBank:DB00508
database cross reference: Drug_Central:2742
database cross reference: HMDB:HMDB0014650
database cross reference: KEGG:D00390
database cross reference: LINCS:LSM-3421
database cross reference: PMID:1650428
database cross reference: PMID:24959397
database cross reference: Patent:GB813861
database cross reference: Reaxys:335308
database cross reference: Wikipedia:Triflupromazine
has exact synonym: N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-amine
has_obo_namespace: chebi_ontology
has_related_synonym: 10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine
has_related_synonym: 2-(Trifluoromethyl)promazine
has_related_synonym: 2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine
has_related_synonym: trifluopromazine
has_related_synonym: triflupromazina
has_related_synonym: triflupromazine
has_related_synonym: triflupromazinum
id: CHEBI:9711
in subset: 3 STAR

trimipramine
type: Class
subclass of: organonitrogen compound
definition: A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)-2-methylpropyl group at the nitrogen atom. It is used as an antidepressant.
imported from: chebi.owl
charge: 0
formula: C20H26N2
inchi: InChI=1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3
inchikey: ZSCDBOWYZJWBIY-UHFFFAOYSA-N
mass: 294.43392
monoisotopicmass: 294.20960
smiles: CC(CN(C)C)CN1c2ccccc2CCc2ccccc12
database cross reference: Beilstein:1321466
database cross reference: CAS:739-71-9
database cross reference: DrugBank:DB00726
database cross reference: Drug_Central:2758
database cross reference: HMDB:HMDB0014864
database cross reference: KEGG:D00394
database cross reference: LINCS:LSM-1371
database cross reference: PMID:22642681
database cross reference: PMID:25178259
database cross reference: Patent:CN103893187
database cross reference: Reaxys:1321466
database cross reference: Wikipedia:Trimipramine
has exact synonym: 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine
has exact synonym: Trimipramine
has_obo_namespace: chebi_ontology
has_related_synonym: 10,11-dihydro-N,N,beta-trimethyl-5H-dibenz[b,f]azepine-5-propanamine
has_related_synonym: 5-(gamma-dimethylamino-beta-methylpropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine
has_related_synonym: 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenz[b,f]azepine
has_related_synonym: RP-7162
has_related_synonym: Sapilent
has_related_synonym: Trimeprimine
has_related_synonym: beta-methylimipramine
has_related_synonym: trimeproprimine
id: CHEBI:9738
in subset: 3 STAR

venlafaxine
type: Class
subclass of: ether
subclass of: organonitrogen compound
definition: A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-methoxyphenyl group.
imported from: chebi.owl
charge: 0
formula: C17H27NO2
inchi: InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
inchikey: PNVNVHUZROJLTJ-UHFFFAOYSA-N
mass: 277.40182
monoisotopicmass: 277.20418
smiles: COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
database cross reference: Beilstein:4234848
database cross reference: CAS:93413-69-5
database cross reference: DrugBank:DB00285
database cross reference: Drug_Central:2813
database cross reference: HMDB:HMDB0005016
database cross reference: KEGG:C07187
database cross reference: KEGG:D08670
database cross reference: LINCS:LSM-1616
database cross reference: PMID:11098420
database cross reference: PMID:12409680
database cross reference: PMID:18321472
database cross reference: Reaxys:4234848
database cross reference: Wikipedia:Venlafaxine
has exact synonym: 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol
has exact synonym: Venlafaxine
has_obo_namespace: chebi_ontology
has_related_synonym: Elafax
has_related_synonym: venlafaxina
has_related_synonym: venlafaxine
has_related_synonym: venlafaxinum
id: CHEBI:9943
in subset: 3 STAR

SH-SY5Y cell
type: Class
subclass of: In Vitro Model
细胞系LINCS ID: LCL-2000
alternative term: SH-SY5Y
definition source: https://www.atcc.org/en/Products/Cells_and_Microorganisms/By_Tissue/Bone_Marrow/CRL-2266.aspx
imported from: clo.owl
alternative term: SHSY5Y
label: SH-SY5Y 细胞 @zh
see also: ATCC: CRL-2266

neuronal stem cell
type: Class
subclass of: Cell
definition: Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors.
imported from: cl.owl
database cross reference: BTO:0002881
database cross reference: CALOHA:TS-2360
database cross reference: FMA:86684
has exact synonym: NSC
has exact synonym: neural stem cell
has_obo_namespace: cell

ependymal cell
type: Class
subclass of: eukaryotic cell
definition: A neurectoderm derived cell that lines the neural lumen.
imported from: cl.owl
database cross reference: BTO:0001724
database cross reference: FMA:70550
has exact synonym: ependymocyte
has_obo_namespace: cell

granulocyte
type: Class
subclass of: leukocyte
definition: A leukocyte with abundant granules in the cytoplasm.
imported from: cl.owl
database cross reference: BTO:0000539
database cross reference: BTO:0001026
database cross reference: CALOHA:TS-0422
database cross reference: FMA:62854
has exact synonym: granular leucocyte
has exact synonym: granular leukocyte
has exact synonym: polymorphonuclear leukocyte
has_obo_namespace: cell

interneuron
type: Class
subclass of: neuron
definition: Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.
imported from: cl.owl
database cross reference: BTO:0003811
database cross reference: FBbt:00005125
database cross reference: FMA:67313
database cross reference: WBbt:0005113
has_obo_namespace: cell

adrenergic neuron
type: Class
subclass of: neuron
imported from: cl.owl
has_obo_namespace: cell

CNS neuron (sensu Vertebrata)
type: Class
subclass of: neuron
imported from: cl.owl
has_obo_namespace: cell

basket cell
type: Class
subclass of: CNS neuron (sensu Vertebrata)
imported from: cl.owl
has_obo_namespace: cell

granule cell
type: Class
subclass of: CNS neuron (sensu Vertebrata)
imported from: cl.owl
database cross reference: BTO:0003393
has_obo_namespace: cell

Purkinje cell
type: Class
subclass of: central nervous system neuron
definition: The output neuron of the cerebellar cortex.
imported from: cl.owl
database cross reference: BTO:0001011
database cross reference: CALOHA:TS-0845
database cross reference: FMA:67969
has exact synonym: Purkinje neuron
has exact synonym: Purkinje's cell
has exact synonym: cerebellar Purkinje cell
has exact synonym: cerebellum Purkinje cell
has_obo_namespace: cell

glial cell
type: Class
subclass of: neural cell
definition: A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.
imported from: cl.owl
database cross reference: BTO:0002606
database cross reference: CALOHA:TS-0415
database cross reference: FMA:54536
has exact synonym: neuroglial cell
has_obo_namespace: cell
has_related_synonym: neuroglia

astrocyte
type: Class
subclass of: glial cell
definition: A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury.
imported from: cl.owl
database cross reference: BTO:0000099
database cross reference: CALOHA:TS-0060
database cross reference: FMA:54537
has exact synonym: astrocytic glia
has_obo_namespace: cell
comment: Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive.

oligodendrocyte
type: Class
subclass of: glial cell
definition: A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system.
imported from: cl.owl
database cross reference: BTO:0000962
database cross reference: CALOHA:TS-0709
database cross reference: FMA:54540
has exact synonym: OLs
has_obo_namespace: cell
has_related_synonym: oligodendroglia
comment: Oligodendrocytes are reportedly MDP-positive and CD4-negative.

microglial cell
type: Class
subclass of: glial cell
definition: A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive.
imported from: cl.owl
has_broad_synonym: brain macrophage
database cross reference: BTO:0000078
database cross reference: BTO:0000962
database cross reference: FMA:54539
database cross reference: FMA:54540
has exact synonym: brain-resident macrophage
has exact synonym: hortega cells
has exact synonym: microglia
has exact synonym: microgliocyte
has_obo_namespace: cell
has_related_synonym: MF.microglia.CNS
comment: Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.

macrophage
type: Class
subclass of: leukocyte
definition: A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
imported from: cl.owl
database cross reference: BTO:0000801
database cross reference: CALOHA:TS-0587
database cross reference: FMA:63261
database cross reference: FMA:83585
has exact synonym: histiocyte
has_obo_namespace: cell
comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.

eukaryotic cell
type: Class
subclass of: Cell
imported from: cl.owl
has_obo_namespace: cell

neuron
type: Class
subclass of: neural cell
definition: The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
imported from: cl.owl
database cross reference: BTO:0000938
database cross reference: CALOHA:TS-0683
database cross reference: FBbt:00005106
database cross reference: FMA:54527
database cross reference: VHOG:0001483
database cross reference: WBbt:0003679
has exact synonym: nerve cell
has_obo_namespace: cell
comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.

lymphocyte
type: Class
subclass of: leukocyte
definition: A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
imported from: cl.owl
database cross reference: BTO:0000775
database cross reference: CALOHA:TS-0583
database cross reference: FMA:62863
database cross reference: VHOG:0001535
has_obo_namespace: cell
comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)

monocyte
type: Class
subclass of: leukocyte
definition: Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.
imported from: cl.owl
database cross reference: BTO:0000876
database cross reference: CALOHA:TS-0638
database cross reference: FMA:62864
has_obo_namespace: cell
comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.

pyramidal neuron
type: Class
subclass of: CNS neuron (sensu Vertebrata)
definition: Pyramidal neurons have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala.
imported from: cl.owl
database cross reference: BTO:0003102
database cross reference: FMA:67310
database cross reference: FMA:86775
database cross reference: NIFSTD:sao862606388
has exact synonym: projection neuron
has exact synonym: pyramidal cell
has exact synonym: pyramidal neuron
has_obo_namespace: cell

GABAergic neuron
type: Class
subclass of: neuron
definition: A neuron that uses GABA as a vesicular neurotransmitter
imported from: cl.owl
database cross reference: FMA:84788
database cross reference: WBbt:0005190
has exact synonym: GABA-ergic neuron
has_obo_namespace: cell

pericyte cell
type: Class
subclass of: eukaryotic cell
definition: An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells.
imported from: cl.owl
has_alternative_id: CL:0000184
database cross reference: BTO:0002441
database cross reference: FMA:63174
has exact synonym: ARC
has exact synonym: adventitial reticular cell
has exact synonym: cell of Rouget
has exact synonym: pericyte
has exact synonym: pericyte of Rouget
has_obo_namespace: cell
has_related_synonym: adventitial cell
comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A.

glutamatergic neuron
type: Class
subclass of: neuron
imported from: cl.owl
database cross reference: WBbt:0006829
has_obo_namespace: cell

dopaminergic neuron
type: Class
subclass of: neuron
definition: A neuron that releases dopamine as a neurotransmitter.
imported from: cl.owl
database cross reference: BTO:0004032
database cross reference: FMA:84787
database cross reference: WBbt:0006746
has exact synonym: dopaminergic cell
has_obo_namespace: cell

leukocyte
type: Class
subclass of: eukaryotic cell
definition: An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
imported from: cl.owl
database cross reference: BTO:0000751
database cross reference: CALOHA:TS-0549
database cross reference: FMA:62852
has exact synonym: immune cell
has exact synonym: leucocyte
has exact synonym: white blood cell
has_obo_namespace: cell

basophil
type: Class
subclass of: granulocyte
definition: Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive.
imported from: cl.owl
has_broad_synonym: polymorphonuclear leucocyte
has_broad_synonym: polymorphonuclear leukocyte
database cross reference: BTO:0000129
database cross reference: CALOHA:TS-0073
database cross reference: FMA:62862
has exact synonym: basophilic leucocyte
has exact synonym: basophilic leukocyte
has_obo_namespace: cell
comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive.

eosinophil
type: Class
subclass of: granulocyte
definition: Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive.
imported from: cl.owl
has_broad_synonym: polymorphonuclear leucocyte
has_broad_synonym: polymorphonuclear leukocyte
database cross reference: BTO:0000399
database cross reference: CALOHA:TS-0279
database cross reference: FMA:62861
has exact synonym: eosinocyte
has exact synonym: eosinophilic granulocyte
has exact synonym: eosinophilic leucocyte
has exact synonym: eosinophilic leukocyte
has_obo_namespace: cell
comment: Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte.

neutrophil
type: Class
subclass of: granulocyte
definition: Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
imported from: cl.owl
has_broad_synonym: PMN
has_broad_synonym: poly
has_broad_synonym: polymorphonuclear leucocyte
has_broad_synonym: polymorphonuclear leukocyte
has_broad_synonym: polymorphonuclear neutrophil
has_broad_synonym: polynuclear neutrophilic leucocyte
has_broad_synonym: polynuclear neutrophilic leukocyte
database cross reference: BTO:0000130
database cross reference: CALOHA:TS-0688
database cross reference: FMA:62860
has exact synonym: neutrocyte
has exact synonym: neutrophil leucocyte
has exact synonym: neutrophil leukocyte
has exact synonym: neutrophilic leucocyte
has exact synonym: neutrophilic leukocyte
has_obo_namespace: cell

serotonergic neuron
type: Class
subclass of: neuron
definition: A neuron that releases serotonin as a neurotransmitter.
imported from: cl.owl
has_alternative_id: CL:0000403
database cross reference: FBbt:00005133
database cross reference: WBbt:0006837
has exact synonym: 5-HT neuron
has exact synonym: 5-hydroxytryptamine neuron
has_obo_namespace: cell
has_related_synonym: serotinergic neuron

neural cell
type: Class
subclass of: eukaryotic cell
definition: A cell that is part of the nervous system.
imported from: cl.owl
created by: tmeehan
creation date: 2010-09-15T01:34:57Z
database cross reference: CALOHA:TS-2040
database cross reference: FMA:70333
has_obo_namespace: cell

Schwann cell
type: Class
subclass of: glial cell
definition: A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function.
imported from: cl.owl
created by: tmeehan
creation date: 2011-03-02T01:19:27Z
database cross reference: BTO:0001220
database cross reference: CALOHA:TS-0898
has_obo_namespace: cell

hippocampal neuron
type: Class
subclass of: CNS neuron (sensu Vertebrata)
definition: A neuron of the hippocampus.
imported from: cl.owl
created by: tmeehan
creation date: 2011-03-06T07:31:49Z
has_obo_namespace: cell

medium spiny neuron
type: Class
subclass of: central nervous system neuron
definition: The inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus.
imported from: cl.owl
database cross reference: BTO:0004778
has exact synonym: striatal medium spiny neuron
has_obo_namespace: cl
has_related_synonym: medium-sized densely spiny neuron

central nervous system neuron
type: Class
subclass of: neuron
definition: Any neuron that is part of a central nervous system.
imported from: cl.owl
created by: TermGenie
creation date: 2014-06-25T01:17:43Z
has_obo_namespace: cell
id: CL:2000029

clinical measurement
type: Class
subclass of: measurement datum
imported from: cmo.owl
def: A quantitative or qualitative value which is the result of an act of assessing a morphological or physiological state or property in a single individual or sample or a group of individuals or samples, based on direct observation or experimental manipulation.

cardiovascular measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
def: Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart and/or blood vessels.

blood chemistry measurement
type: Class
subclass of: blood measurement
imported from: cmo.owl
def: A quantification of a parameter of the chemical composition of blood.
has_related_synonym: blood molecular composition measurement

red blood cell count
type: Class
subclass of: blood cell measurement
imported from: cmo.owl
def: The number of red blood cells in a specified volume of blood most commonly 1 cubic millimeter (i.e. 1 microliter) of peripheral venous blood.
has exact synonym: erythrocyte count

white blood cell count
type: Class
subclass of: blood cell measurement
imported from: cmo.owl
def: The number of white blood cells in a specified volume of blood.
has_related_synonym: leukocyte count
has_related_synonym: white corpuscle count

blood measurement
type: Class
subclass of: clinical measurement
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
imported from: cmo.owl
def: A measurement of the blood, it's contents, cells or other factors contained within the blood.

blood cell measurement
type: Class
subclass of: blood measurement
subclass of: cell measurement
imported from: cmo.owl
def: A value resulting from the quantification of a morphological or physiological parameter of blood cells, i.e. cells native to the circulation, including those of erythroid, lymphoid, myeloid and monocytic lineages. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning.

body mass index (BMI)
type: Class
subclass of: clinical measurement
imported from: cmo.owl
def: A measurement relating body weight to height in an organism; typically calculated as the weight of an individual divided by the height of that individual squared. For quadrupeds, the square of body height is often replaced by the square of body length.
has_related_synonym: BMI

cell measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:30:36Z
def: Any quantification of a morphological or physiological parameter of one or more cells. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning.

pulse
type: Class
subclass of: cardiovascular measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-08-04T10:37:40Z
def: The count of the rhythmic contractions and expansions of an artery due to the surge of blood from the beat of the heart.

cerebrospinal fluid measurement
type: Class
subclass of: clinical measurement
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
imported from: cmo.owl
created by: JSmith
creation date: 2013-01-07T16:14:04Z
def: Any measurement of the fluid contained within the ventricles of the brain, the subarachnoid space, and the central canal of the spinal cord.

masking design
type: Class
subclass of: information content entity
definition: The party or parties involved in the clinical trial who are prevented from having knowledge of the interventions assigned to individual participants.
imported from: cto.owl
has_related_synonym: blinding
has_related_synonym: masking

open blinded design
type: Class
subclass of: masking design
definition: a study design in which the subjects and the investigators are permitted to know which subject is receiving which treatment
imported from: cto.owl
has exact synonym: open blind
has exact synonym: open label

clinical trial phase
type: Class
subclass of: quality
definition: The quality of a clinical trial that studies a drug or biological product. The phase is based on the study's objective, the number of participants, and other characteristics. According to USA FDA, there are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4.
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: clinical trial stage
definition source: https://www.clinicaltrials.gov/ct2/help/glossary/phase
imported from: cto.owl
has_narrow_synonym: phase

clinical trial phase 1
type: Class
subclass of: clinical trial phase
definition: A clinical trial phase that represents the first-in-man trial, which tests within a small group of people (typically 20-80) to evaluate safety, determine safe dosage ranges, and begin to identify side effects. A drug's side effects could be subtle or long term, or may only happen with a few people, so phase 1 trials are not expected to identify all side effects.
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase 1
alternative term: Phase I
definition source: http://purl.obolibrary.org/obo/NCIT_C15600
definition source: https://en.wikipedia.org/wiki/Clinical_trial
imported from: cto.owl
UMLS_CUI: C0920321
NCIT code: C15600

clinical trial phase 2
type: Class
subclass of: clinical trial phase
definition: A clinical trial phase that is designed to study a biomedical or behavioral intervention in a larger group of people (several hundred), to evaluate the drug's effectiveness for a particular indication in patients with the disease or condition under study, and to determine the common short-term side effects and risks associated with the intervention. [def-source: NCI]
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase II
definition source: http://purl.obolibrary.org/obo/NCIT_C15601
definition source: https://en.wikipedia.org/wiki/Clinical_trial
imported from: cto.owl
UMLS_CUI: C0282460
NCIT code: C15601

clinical trial phase 3
type: Class
subclass of: clinical trial phase
definition: A clinical trial phase that is designed to investigate the efficacy of the biomedical or behavioral intervention in large groups of human subjects (from several hundred to several thousand), to confirm efficacy, to monitor adverse reactions to the new medication or treatment regimen with respect to long-term use and by comparing the intervention to other standard or experimental interventions as well as to a placebo. [def-source: NCI]
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase III
definition source: http://purl.obolibrary.org/obo/NCIT_C15602
definition source: https://en.wikipedia.org/wiki/Clinical_trial
imported from: cto.owl
UMLS_CUI: C0282461
NCIT code: C15602

clinical trial phase 4
type: Class
subclass of: clinical trial phase
definition: A clinical trial phase that is designed for a randomized, controlled trial to evaluate the long-term safety and efficacy of a drug for a given indication. Often they are designed to study side effects that may have become apparent after the phase III study was completed. [def-source: NCI]
definition editor: Leon Li, Asiyah Lin, Oliver He
alternative term: Phase IV
definition source: https://en.wikipedia.org/wiki/Clinical_trial
imported from: cto.owl
UMLS_CUI: C0282462
NCIT code: C15603

clinical trial
type: Class
subclass of: planned process
definition: a clinical trial is a medical interventional study where participants are assigned prospectively to an intervention or interventions according to a protocol to evaluate the safety and efficacy of the intervention(s) on biomedical or other health related outcomes. The Interventions include but are not restricted to drugs, cells and other biological products, surgical procedures, radiologic procedures, devices, behavioral treatments, process-of-care changes, preventive care, etc.
definition editor: Oliver He, Asiyah Yu Lin, Qingliang Li
alternative term: interventional trial
definition source: https://clinicaltrials.gov/ct2/search/map
definition source: https://en.wikipedia.org/wiki/Clinical_trial
definition source: https://prsinfo.clinicaltrials.gov/definitions.html
definition source: https://www.who.int/ictrp/en/
imported from: cto.owl

disease of metabolism
type: Class
subclass of: disease
definition: A disease that involving errors in metabolic processes of building or degradation of molecules.
imported from: doid.owl
database cross reference: ICD10CM:E88.9
database cross reference: ICD9CM:277.9
database cross reference: MESH:D008659
database cross reference: NCI:C3235
database cross reference: SNOMEDCT_US_2020_09_01:75934005
database cross reference: UMLS_CUI:C0025517
has exact synonym: metabolic disease
has_obo_namespace: disease_ontology
id: DOID:0014667
in subset: DO AGR slim
in subset: DO GXD slim
in subset: NCIthesaurus

disease by infectious agent
type: Class
subclass of: disease
definition: A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions.
imported from: doid.owl
IEDB alternative term: infectious disease
has_alternative_id: DOID:10115
has_alternative_id: DOID:11078
has_alternative_id: DOID:1304
has_alternative_id: DOID:1321
has_alternative_id: DOID:2040
has_alternative_id: DOID:2288
has_alternative_id: DOID:3099
has_alternative_id: DOID:4120
has_alternative_id: DOID:4620
has_alternative_id: DOID:5256
has_alternative_id: DOID:945
has_alternative_id: DOID:95
has_alternative_id: DOID:9532
has_alternative_id: DOID:9696
database cross reference: ICD9CM:079.0
database cross reference: UMLS_CUI:C0001485
has exact synonym: infectious disease
has_obo_namespace: disease_ontology
id: DOID:0050117
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus
comment: DO:wk

developmental disorder of mental health
type: Class
subclass of: disease of mental health
definition: A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060037

specific developmental disorder
type: Class
subclass of: developmental disorder of mental health
definition: A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060038

pervasive developmental disorder
type: Class
subclass of: developmental disorder of mental health
definition: A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors.
imported from: doid.owl
has_alternative_id: DOID:1208
database cross reference: ICD9CM:299.80
database cross reference: UMLS_CUI:C0154451
has exact synonym: pervasive development disorder
has_obo_namespace: disease_ontology
id: DOID:0060040

sexual disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health that involves the impairment in normal sexual functioning.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0060043

mild cognitive impairment
type: Class
subclass of: cognitive disorder
subclass of: Restriction
  on property: isClinicalMarkerFor
  some values from: Alzheimer's disease
definition: A cognitive disorder that is characterized by objective impairment in cognition with minimal impairment of their capacity to undertake the instrumental activities of daily living.
imported from: doid.owl
has_obo_namespace: disease_ontology
id: DOID:0080832

Alzheimer's disease
type: Class
subclass of: dementia
subclass of: tauopathy
definition: A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
imported from: doid.owl
database cross reference: EFO:0000249
database cross reference: GARD:10254
database cross reference: ICD10CM:G30
database cross reference: ICD9CM:331.0
database cross reference: KEGG:05010
database cross reference: MESH:D000544
database cross reference: NCI:C2866
database cross reference: SNOMEDCT_US_2020_03_01:73768007
database cross reference: SNOMEDCT_US_2020_09_01:73768007
database cross reference: UMLS_CUI:C0002395
has exact synonym: Alzheimer disease
has exact synonym: Alzheimers dementia
has_obo_namespace: disease_ontology
id: DOID:10652
in subset: DO RAD slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

hypertension
type: Class
subclass of: cardiovascular system disease
subclass of: Restriction
  on property: isRiskFactorFor
  some values from: Alzheimer's disease
definition: An artery disease characterized by chronic elevated blood pressure in the arteries.
imported from: doid.owl
database cross reference: EFO:0000537
database cross reference: ICD10CM:I10
database cross reference: ICD9CM:401-405.99
database cross reference: MESH:D006973
database cross reference: NCI:C3117
database cross reference: SNOMEDCT_US_2020_09_01:38341003
database cross reference: UMLS_CUI:C0020538
has exact synonym: HTN
has exact synonym: High blood pressure
has exact synonym: hyperpiesia
has exact synonym: vascular hypertensive disorder
has_obo_namespace: disease_ontology
has_related_synonym: hypertensive disease
id: DOID:10763
in subset: NCIthesaurus

multiple personality disorder
type: Class
subclass of: disease of mental health
definition: A dissociative disorder that involves the simultaneous display of multiple distinct identities or personalities.
imported from: doid.owl
database cross reference: ICD10CM:F44.81
database cross reference: ICD9CM:300.14
database cross reference: ICD9CM_2006:300.14
database cross reference: MESH:D009105
database cross reference: NCI:C94330
database cross reference: SNOMEDCT_US_2018_03_01:31611000
database cross reference: UMLS_CUI:C0026773
has exact synonym: Dissociative identity disorder
has_obo_namespace: disease_ontology
id: DOID:10934
in subset: NCIthesaurus

heart disease
type: Class
subclass of: cardiovascular system disease
subclass of: Restriction
  on property: isRiskFactorFor
  some values from: Alzheimer's disease
definition: A cardiovascular system disease that involves the heart.
imported from: doid.owl
database cross reference: ICD10CM:I51.9
database cross reference: ICD9CM:429.9
database cross reference: MESH:D006331
database cross reference: NCI:C3079
database cross reference: SNOMEDCT_US_2020_09_01:194707003
database cross reference: UMLS_CUI:C0018799
has_obo_namespace: disease_ontology
id: DOID:114
in subset: DO FlyBase slim
in subset: DO RAD slim
in subset: NCIthesaurus

Pick's disease
type: Class
subclass of: neurodegenerative disease
imported from: doid.owl
database cross reference: GARD:7392
database cross reference: ICD10CM:G31.01
database cross reference: ICD9CM:331.11
database cross reference: MESH:D020774
database cross reference: NCI:C85008
database cross reference: OMIM:172700
database cross reference: SNOMEDCT_US_2020_03_01:154998003
database cross reference: UMLS_CUI:C0236642
has exact synonym: Dementia in Pick's disease
has exact synonym: LOBAR ATROPHY OF BRAIN
has exact synonym: PICK DISEASE OF BRAIN
has exact synonym: Pick disease
has_obo_namespace: disease_ontology
id: DOID:11870
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Lewy body dementia
type: Class
subclass of: dementia
definition: A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities.
imported from: doid.owl
database cross reference: GARD:3243
database cross reference: ICD10CM:G31.83
database cross reference: ICD9CM:331.82
database cross reference: MESH:D020961
database cross reference: NCI:C84826
database cross reference: OMIM:127750
database cross reference: SNOMEDCT_US_2020_09_01:192808003
database cross reference: UMLS_CUI:C0752347
has exact synonym: Dementia with Lewy bodies
has exact synonym: Diffuse Lewy body disease
has exact synonym: Lewy body disease
has exact synonym: Senile dementia of the Lewy body type
has_obo_namespace: disease_ontology
id: DOID:12217
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Huntington's disease
type: Class
subclass of: neurodegenerative disease
definition: A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities.
imported from: doid.owl
database cross reference: GARD:6677
database cross reference: ICD10CM:G10
database cross reference: ICD9CM:333.4
database cross reference: KEGG:05016
database cross reference: MESH:D006816
database cross reference: NCI:C82342
database cross reference: OMIM:143100
database cross reference: SNOMEDCT_US_2020_03_01:155006000
database cross reference: SNOMEDCT_US_2020_09_01:155006000
database cross reference: UMLS_CUI:C0020179
has exact synonym: HD
has exact synonym: Huntington disease
has exact synonym: Huntington's chorea
has_obo_namespace: disease_ontology
id: DOID:12858
in subset: DO FlyBase slim
in subset: NCIthesaurus

cardiovascular system disease
type: Class
subclass of: disease
definition: A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.
imported from: doid.owl
has_alternative_id: DOID:73
database cross reference: ICD9CM:429.2
database cross reference: MESH:D002318
database cross reference: NCI:C2931
database cross reference: SNOMEDCT_US_2020_09_01:266275004
database cross reference: UMLS_CUI:C0007222
has exact synonym: disease of subdivision of hemolymphoid system
has_obo_namespace: disease_ontology
id: DOID:1287
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: DO RAD slim
in subset: NCIthesaurus

neurodegenerative disease
type: Class
subclass of: central nervous system disease
definition: A central nervous system disease that results in the progressive deterioration of function or structure of neurons.
imported from: doid.owl
has_alternative_id: DOID:4874
database cross reference: ICD10CM:G31.9
database cross reference: MESH:D019636
database cross reference: NCI:C27090
database cross reference: SNOMEDCT_US_2020_03_01:362975008
database cross reference: SNOMEDCT_US_2020_09_01:362975008
database cross reference: UMLS_CUI:C0524851
database cross reference: UMLS_CUI:C1285162
has exact synonym: Neurodegenerative disease
has exact synonym: degenerative disease
has_obo_namespace: disease_ontology
id: DOID:1289
in subset: DO FlyBase slim
in subset: NCIthesaurus

dementia
type: Class
subclass of: cognitive disorder
definition: A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior.
imported from: doid.owl
database cross reference: ICD9CM:290.8
database cross reference: MESH:D003704
database cross reference: UMLS_CUI:C0154319
has_obo_namespace: disease_ontology
id: DOID:1307

Parkinson's disease
type: Class
subclass of: neurodegenerative disease
definition: A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.
imported from: doid.owl
database cross reference: EFO:0002508
database cross reference: GARD:10251
database cross reference: ICD10CM:G20
database cross reference: ICD9CM:332
database cross reference: KEGG:05012
database cross reference: MESH:D010300
database cross reference: NCI:C26845
database cross reference: OMIM:PS168600
database cross reference: ORDO:2828
database cross reference: SNOMEDCT_US_2020_09_01:49049000
database cross reference: UMLS_CUI:C0030567
has exact synonym: Parkinson disease
has exact synonym: paralysis agitans
has_obo_namespace: disease_ontology
id: DOID:14330
in subset: DO FlyBase slim
in subset: DO rare slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

hypothyroidism
type: Class
subclass of: disease
definition: A thyroid gland disease which involves an underproduction of thyroid hormone.
imported from: doid.owl
has_alternative_id: DOID:11630
database cross reference: EFO:0004705
database cross reference: ICD10CM:E03.9
database cross reference: ICD9CM:244.9
database cross reference: MESH:D007037
database cross reference: NCI:C26800
database cross reference: SNOMEDCT_US_2020_09_01:267465007
database cross reference: UMLS_CUI:C0020676
has exact synonym: Thyroid deficiency
has exact synonym: Thyroid insufficiency
has_obo_namespace: disease_ontology
id: DOID:1459
in subset: NCIthesaurus

disease of mental health
type: Class
subclass of: disease
definition: A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture.
imported from: doid.owl
database cross reference: ICD10CM:F99
database cross reference: ICD10CM:F99-F99
database cross reference: MESH:D001523
database cross reference: NCI:C2893
database cross reference: SNOMEDCT_US_2018_03_01:74732009
database cross reference: SNOMEDCT_US_2020_09_01:74732009
database cross reference: UMLS_CUI:C0004936
has_obo_namespace: disease_ontology
id: DOID:150
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: DO RAD slim
in subset: NCIthesaurus

personality disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work.
imported from: doid.owl
database cross reference: ICD9CM:301.8
database cross reference: ICD9CM:301.89
database cross reference: UMLS_CUI:C0029707
has exact synonym: character disorder
has_obo_namespace: disease_ontology
id: DOID:1510

cognitive disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health that affects cognitive functions including memory processing, perception and problem solving.
imported from: doid.owl
database cross reference: ICD10CM:F09
database cross reference: MESH:D019965
database cross reference: NCI2004_11_17:C34870
database cross reference: NCI:C34870
database cross reference: UMLS_CUI:C0029227
has exact synonym: cognitive disease
has_obo_namespace: disease_ontology
has_related_synonym: Organic Mental disorder
id: DOID:1561
in subset: NCIthesaurus

musculoskeletal system disease
type: Class
subclass of: disease of anatomical entity
definition: A disease of anatomical entity that occurs in the muscular and/or skeletal system.
imported from: doid.owl
database cross reference: MESH:D009140
database cross reference: NCI:C107377
database cross reference: SNOMEDCT_US_2018_03_01:928000
database cross reference: UMLS_CUI:C0026857
has_obo_namespace: disease_ontology
id: DOID:17
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

anxiety disorder
type: Class
subclass of: cognitive disorder
definition: A cognitive disorder that involves an excessive, irrational dread of everyday situations.
imported from: doid.owl
has_alternative_id: DOID:12884
database cross reference: ICD10CM:F41.9
database cross reference: MESH:D001008
database cross reference: NCI:C2878
database cross reference: OMIM:607834
database cross reference: SNOMEDCT_US_2018_03_01:65673007
database cross reference: UMLS_CUI:C0003469
has exact synonym: anxiety
has exact synonym: anxiety state
has_obo_namespace: disease_ontology
id: DOID:2030
in subset: NCIthesaurus

syndrome
type: Class
subclass of: disease
definition: A disease characterized by a group of signs and symptoms that occur together and characterize a particular abnormality.
imported from: doid.owl
database cross reference: MESH:D013577
database cross reference: NCI:C28193
database cross reference: SNOMEDCT_US_2018_03_01:64572001
database cross reference: SNOMEDCT_US_2020_09_01:64572001
database cross reference: UMLS_CUI:C0039082
has_obo_namespace: disease_ontology
id: DOID:225
in subset: DO AGR slim
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

psychotic disorder
type: Class
subclass of: cognitive disorder
definition: A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality.
imported from: doid.owl
database cross reference: EFO:0000677
database cross reference: ICD9CM:298.8
database cross reference: UMLS_CUI:C0029516
has exact synonym: mental or behavioural disorder
has_obo_namespace: disease_ontology
id: DOID:2468

substance abuse
type: Class
subclass of: substance-related disorder
definition: A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.
imported from: doid.owl
database cross reference: MESH:D019966
database cross reference: NCI:C16522
database cross reference: SNOMEDCT_US_2020_09_01:26416006
database cross reference: UMLS_CUI:C0013146
has_obo_namespace: disease_ontology
id: DOID:302
in subset: NCIthesaurus

substance-related disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning.
imported from: doid.owl
database cross reference: MESH:D019966
database cross reference: NCI:C92203
database cross reference: UMLS_CUI:C0236969
has_obo_namespace: disease_ontology
id: DOID:303
in subset: NCIthesaurus

central nervous system disease
type: Class
subclass of: nervous system disease
definition: A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.
imported from: doid.owl
database cross reference: ICD10CM:G96.9
database cross reference: MESH:D002493
database cross reference: NCI:C2934
database cross reference: SNOMEDCT_US_2020_03_01:267144009
database cross reference: SNOMEDCT_US_2020_09_01:267144009
database cross reference: UMLS_CUI:C0007682
has_obo_namespace: disease_ontology
id: DOID:331
in subset: DO AGR slim
in subset: DO GXD slim
in subset: NCIthesaurus

mood disorder
type: Class
subclass of: cognitive disorder
definition: A cognitive disorder that involves a disturbance in mood as the predominant underlying feature.
imported from: doid.owl
database cross reference: EFO:0004247
database cross reference: ICD10CM:F30-F39
database cross reference: ICD10CM:F39
database cross reference: MESH:D019964
database cross reference: NCI:C92200
database cross reference: SNOMEDCT_US_2018_03_01:46206005
database cross reference: SNOMEDCT_US_2018_03_01:74421008
database cross reference: UMLS_CUI:C0525045
has exact synonym: episodic mood disorder
has_obo_namespace: disease_ontology
id: DOID:3324
in subset: NCIthesaurus
comment: Updating outdated UMLS CUI.

gastritis
type: Class
subclass of: disease
definition: A stomach disease that is an inflammation of the lining of the stomach.
imported from: doid.owl
has_alternative_id: DOID:4032
has_alternative_id: DOID:8697
has_alternative_id: DOID:8845
has_alternative_id: DOID:9190
database cross reference: ICD10CM:K29.7
database cross reference: MESH:D005756
database cross reference: NCI:C26780
database cross reference: SNOMEDCT_US_2020_09_01:155711008
database cross reference: UMLS_CUI:C0017152
has exact synonym: Erosive Gastritis
has exact synonym: Erosive gastropathy
has exact synonym: acute gastric mucosal erosion
has_obo_namespace: disease_ontology
id: DOID:4029
in subset: NCIthesaurus

somatoform disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate.
imported from: doid.owl
has_alternative_id: DOID:10133
has_alternative_id: DOID:144
database cross reference: CSP2005:2482-7019
database cross reference: ICD10CM:F45
database cross reference: ICD10CM:F45.0
database cross reference: ICD10CM:F45.9
database cross reference: ICD9CM:300.8
database cross reference: ICD9CM:300.81
database cross reference: MESH:D013001
database cross reference: NCI:C34956
database cross reference: SNOMEDCT_US_2018_03_01:31297008
database cross reference: SNOMEDCT_US_2018_03_01:60368009
database cross reference: SNOMEDCT_US_2018_03_01:9514005
database cross reference: UMLS_CUI:C0037650
database cross reference: UMLS_CUI:C0520482
has exact synonym: physiological malfunction arising from mental factor
has exact synonym: psychophysiologic disorder
has exact synonym: psychosomatic disorder
has_obo_namespace: disease_ontology
id: DOID:4737
in subset: NCIthesaurus

multiple system atrophy
type: Class
subclass of: neurodegenerative disease
imported from: doid.owl
has_alternative_id: DOID:11510
database cross reference: GARD:7079
database cross reference: MESH:D012791
database cross reference: MESH:D019578
database cross reference: NCI:C84909
database cross reference: SNOMEDCT_US_2020_09_01:16576004
database cross reference: SNOMEDCT_US_2020_09_01:230297002
database cross reference: UMLS_CUI:C0037019
database cross reference: UMLS_CUI:C0393571
has exact synonym: Multiple system atrophy
has exact synonym: Shy-Drager syndrome
has_obo_namespace: disease_ontology
id: DOID:4752
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [LS].

sleep disorder
type: Class
subclass of: disease of mental health
definition: A disease of mental health that involves disruption of sleep patterns.
imported from: doid.owl
has_alternative_id: DOID:9028
database cross reference: ICD9CM:307.4
database cross reference: UMLS_CUI:C0154564
has exact synonym: Non-organic sleep disorder
has_obo_namespace: disease_ontology
id: DOID:535
in subset: DO FlyBase slim
in subset: DO RAD slim

genetic disease
type: Class
subclass of: disease
definition: A disease that has_material_basis_in genetic variations in the human genome.
imported from: doid.owl
database cross reference: MESH:D030342
database cross reference: NCI:C3101
database cross reference: SNOMEDCT_US_2018_03_01:32895009
database cross reference: UMLS_CUI:C0019247
has_obo_namespace: disease_ontology
id: DOID:630
in subset: NCIthesaurus

tauopathy
type: Class
subclass of: neurodegenerative disease
definition: A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain.
imported from: doid.owl
database cross reference: MESH:D024801
database cross reference: UMLS_CUI:C0949664
has_obo_namespace: disease_ontology
id: DOID:680
in subset: DO FlyBase slim

disease of anatomical entity
type: Class
subclass of: disease
definition: A disease that manifests in a defined anatomical structure.
imported from: doid.owl
has_alternative_id: DOID:1
has_alternative_id: DOID:2
has_alternative_id: DOID:5
has_alternative_id: DOID:71
has_alternative_id: DOID:72
has_alternative_id: DOID:8
has_obo_namespace: disease_ontology
id: DOID:7

nervous system disease
type: Class
subclass of: disease of anatomical entity
definition: A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.
imported from: doid.owl
database cross reference: ICD10CM:G00-G99
database cross reference: ICD10CM:G98
database cross reference: ICD10CM:G98.8
database cross reference: ICD9CM:349.9
database cross reference: MESH:D009422
database cross reference: NCI:C26835
database cross reference: SNOMEDCT_US_2020_03_01:155262005
database cross reference: UMLS_CUI:C0027765
has_obo_namespace: disease_ontology
id: DOID:863
in subset: DO GXD slim
in subset: DO MGI slim
in subset: NCIthesaurus

vascular dementia
type: Class
subclass of: dementia
definition: A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.
imported from: doid.owl
has_alternative_id: DOID:13915
database cross reference: ICD10CM:F01
database cross reference: ICD9CM:290.4
database cross reference: MESH:D015140
database cross reference: MESH:D015161
database cross reference: NCI:C34522
database cross reference: NCI:C34525
database cross reference: SNOMEDCT_US_2020_09_01:192165000
database cross reference: SNOMEDCT_US_2020_09_01:56267009
database cross reference: UMLS_CUI:C0011263
database cross reference: UMLS_CUI:C0011269
has exact synonym: Multi Infarct Dementia
has exact synonym: multifocal dementia
has_obo_namespace: disease_ontology
id: DOID:8725
in subset: NCIthesaurus

cerebral amyloid angiopathy
type: Class
subclass of: disease of metabolism
definition: An amyloidosis where amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions and progressive dementia.
imported from: doid.owl
database cross reference: MESH:D028243
database cross reference: ORDO:85458
database cross reference: SNOMEDCT_US_2020_09_01:45639009
database cross reference: UMLS_CUI:C0268393
database cross reference: UMLS_CUI:C1510489
database cross reference: UMLS_CUI:C1527338
database cross reference: UMLS_CUI:C1956349
has exact synonym: Cerebral Hemorrhage, Hereditary, with Amyloidosis
has exact synonym: Hereditary Cerebral Hemorrhage with Amyloidosis
has_obo_namespace: disease_ontology
id: DOID:9246
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

frontotemporal dementia
type: Class
subclass of: dementia
subclass of: central nervous system disease
definition: A dementia characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language.
imported from: doid.owl
database cross reference: GARD:8436
database cross reference: MESH:C563003
database cross reference: OMIM:600274
database cross reference: ORDO:282
database cross reference: SNOMEDCT_US_2020_09_01:42369001
database cross reference: UMLS_CUI:C0520716
has exact synonym: Wilhemsen-Lynch disease
has exact synonym: frontotemporal lobar degeneration
has exact synonym: multiple system tauopathy with presenile dementia
has exact synonym: pallidopontonigral degeneration
has_obo_namespace: disease_ontology
id: DOID:9255
in subset: DO FlyBase slim
in subset: DO rare slim
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

type 2 diabetes mellitus
type: Class
subclass of: disease of metabolism
definition: A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
imported from: doid.owl
database cross reference: EFO:0001360
database cross reference: ICD10CM:E11
database cross reference: KEGG:04930
database cross reference: MESH:D003924
database cross reference: NCI:C26747
database cross reference: OMIM:125853
database cross reference: OMIM:601283
database cross reference: OMIM:601407
database cross reference: OMIM:603694
database cross reference: OMIM:608036
database cross reference: SNOMEDCT_US_2020_09_01:44054006
database cross reference: UMLS_CUI:C0011860
has exact synonym: NIDDM
has exact synonym: insulin resistance
has exact synonym: non-insulin-dependent diabetes mellitus
has exact synonym: type 2 diabetes
has exact synonym: type II diabetes mellitus
has_obo_namespace: disease_ontology
id: DOID:9352
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: Xref MGI. OMIM mapping confirmed by DO. [SN].

obesity
type: Class
subclass of: disease of metabolism
subclass of: Restriction
  on property: isRiskFactorFor
  some values from: Alzheimer's disease
definition: An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
imported from: doid.owl
database cross reference: EFO:0001073
database cross reference: ICD10CM:E66.9
database cross reference: ICD9CM:278.00
database cross reference: MESH:D009765
database cross reference: NCI:C159658
database cross reference: OMIM:601665
database cross reference: SNOMEDCT_US_2020_09_01:5476005
database cross reference: UMLS_CUI:C0028754
has_obo_namespace: disease_ontology
id: DOID:9970
in subset: DO FlyBase slim
in subset: NCIthesaurus
comment: OMIM mapping confirmed by DO. [SN].

Isocarboxazid
type: Class
subclass of: antidepressant
has_RxCUI: 6011
imported from: dron.owl

Remoxipride
type: Class
subclass of: antipsychotic agent
has_RxCUI: 35350
imported from: dron.owl

placebo
type: Class
subclass of: processed material
has_RxCUI: 8375
imported from: dron.owl

Isoxsuprine
type: Class
subclass of: drug
has_RxCUI: 6066
imported from: dron.owl

epigallocatechin gallate
type: Class
subclass of: drug
has_RxCUI: 24246
imported from: dron.owl

Adenosine Triphosphate
type: Class
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
subclass of: organic molecule
has_RxCUI: 318
imported from: dron.owl

Phytic Acid
type: Class
subclass of: ester
has_RxCUI: 8302
imported from: dron.owl

Glucose-6-Phosphate
type: Class
subclass of: organophosphorus compound
subclass of: pnictogen molecular entity
subclass of: chalcogen molecular entity
subclass of: ester
subclass of: polyatomic entity
has_RxCUI: 1541246
imported from: dron.owl

mouse
type: Class
subclass of: Animal Model
imported from: emapa.owl
has_obo_namespace: anatomical_structure
id: EMAPA:25765

technique
type: Class
subclass of: planned process
example of usage: Flow cytometry is a technique.
has curation status: IAO_0000120
definition: A technique is a planned process used to accomplish a specific activity or task.
definition editor: PERSON: Melissa Haendel
definition source: http://en.wikipedia.org/wiki/Technique
imported from: ero.owl
comment: Protocol is added to eagle-i temporarily until a relationship between the informatio entity "protocol" and these planned processes is created. This class refers to the axtual process not the document

human study
type: Class
subclass of: planned process
editor preferred label: human study
example of usage: A clinical trial.
has curation status: IAO_0000120
definition: Research project that uses or collects measurements or assessments about humans.
definition editor: PERSON: Melissa Haendel
definition source: OCRe
imported from: ero.owl
comment: This should be imported from OCRE- but they currently have no generic human study type. Def is modified.

epidemiological study
type: Class
subclass of: human study
editor preferred label: epidemiological study
example of usage: A study of the populations and demographic of the avian flu.
has curation status: IAO_0000120
definition: A human study of diseases in populations of humans or other animals, specifically how, when and where they occur. Epidemiological studies can never prove causation, epidemiological evidence can only show that this risk factor is correlated with a higher incidence of disease in the population exposed to that risk factor. The higher the correlation the more certain the association, but it cannot prove the causation.
definition editor: PERSON: Karen Corday
definition source: http://pmep.cce.cornell.edu/profiles/extoxnet/TIB/epidemiology.html
imported from: ero.owl

single blinded study
type: Class
subclass of: Blinded Clinical Study
editor preferred label: single blinded study
has curation status: IAO_0000123
definition: An interventional study in which the person collecting the data knows whether the subjects are in the control or experimental groups but the subjects do not.
definition editor: PERSON: Nicole Vasilevsky
definition source: http://medical-dictionary.thefreedictionary.com/single-blind+study
imported from: ero.owl

double blinded study
type: Class
subclass of: Blinded Clinical Study
editor preferred label: double blinded study
has curation status: IAO_0000123
definition: An interventional study in which neither the subjects of the experiment nor the persons administering the experiment know the critical aspects of the experiment; a double-blind procedure is used to guard against both experimenter bias and placebo effects.
definition editor: PERSON: Nicole Vasilevsky
definition source: http://www.thefreedictionary.com/double-blind+study
imported from: ero.owl

psychological and behavioral intervention
type: Class
subclass of: planned process
editor preferred label: psychological and behavioral intervention
has curation status: IAO_0000123
definition: Psychological or behavior intervention is a combination of program elements, strategies, or modalities designed to influence psychological or behavioral processes or outcomes.
definition editor: PERSON: Matthew Brush
definition source: PERSON: Melanie Wilson
imported from: ero.owl

in vivo bioluminescence imaging system
type: Class
subclass of: imaging technique
example of usage: GFP expressing cells can be visualized by in vivo bioluminescence imaging.
has curation status: IAO_0000120
definition: An image acquisition instrument that is designed for non-invasive in vivo use, to detect bioluminescence, which is based on the expression of luciferase, the light-emitting enzyme of the firefly Photinus pyralis. After the administration of the substrate luciferin, an ATP- and O2-dependent photochemical reaction occurs, resulting in the release of photons by living cells containing luciferase. This photon emission can be detected by a cooled charge-coupled device (CCD) camera, minutes after the administration of the substrate.
definition editor: PERSON: Nicole Vasilevsky
definition source: Contag et al (1997) Photochem Photobiol 66: 523–531
imported from: ero.owl

molecular assay
type: Class
subclass of: assay
example of usage: PCR.
has curation status: IAO_0000120
definition: An assay that generates data about the presence, abundance, structure, function, or activity of biological molecules, or a process that occurs at a molecular level of granularity.
definition editor: PERSON: Nicole Vasilevsky
definition source: PERSON: Matthew Brush
imported from: ero.owl

cerebro-spinal tap
type: Class
subclass of: specimen collection
example of usage: A spinal tap may be performed to determine if a patient has a neurological disorder.
has curation status: IAO_0000120
definition: A technique used to collect cerebrospinal fluid (CSF) from an organism, which involves inserting a needle between the third and fourth lumbar vertebrae in the back and extracting a sample of fluid.
definition editor: PERSON: Nicole Vasilevsky
alternative term: CSF collection
alternative term: Cerebrospinal fluid collection
alternative term: Spinal tap
definition source: http://www.weissandnewberrymds.com/services.htm
imported from: ero.owl

organismal assay
type: Class
subclass of: assay
example of usage: Phenotype characterization of a transgenic mouse.
has curation status: IAO_0000120
definition: An assay that generates data about the physical characteristics, physological functions, or behavior of organisms or viruses.
definition editor: PERSON: Nicole Vasilevsky
definition source: PERSON: Matthew Brush
imported from: ero.owl

physiological assay
type: Class
subclass of: organismal assay
example of usage: Electrocardiogram.
has curation status: IAO_0000120
definition: An organismal assay designed to capture information pertaining to the the organic processes and phenomena of an organism or any of its parts or of a particular bodily process.
definition editor: PERSON: Nicole Vasilevsky
definition source: http://www.merriam-webster.com/dictionary/physiology
imported from: ero.owl

imaging technique
type: Class
subclass of: technique
example of usage: MRI.
has curation status: IAO_0000120
definition: A technique used to create a representation or reproduction of an object's outward form; especially a visual representation (i.e., the formation of an image).
definition editor: PERSON: Nicole Vasilevsky
definition source: http://en.wikipedia.org/wiki/Imaging
imported from: ero.owl

neuropsychological testing
type: Class
subclass of: assay
has curation status: IAO_0000123
definition: A physiological assay that utilizes systematic administration of defined procedures to measure specific psychological functions known to be linked to particular brain structures or pathways in humans.
definition editor: PERSON: Nicole Vasilevsky
definition source: http://en.wikipedia.org/wiki/Neuropsychological_test
imported from: ero.owl

single photon emission computed tomography
type: Class
subclass of: imaging technique
has curation status: IAO_0000123
definition: An imaging technique, in which a gamma camera rotates around the patient and takes pictures from many angles, and a tomographic (cross-sectional) image is generated.
definition editor: PERSON: Nicole Vasilevsky
alternative term: SPECT
definition source: http://www.medterms.com/script/main/art.asp
imported from: ero.owl

survival
type: Class
subclass of: measurement scale
has curation status: IAO_0000123
alternative term: time to failure
imported from: ero.owl

alcohol consumption
type: Class
subclass of: Lifestyle
definition: Consumption of liquids containing ethanol, including the behaviors associated with drinking the alcohol.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-06T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: influencing_factor
has_related_synonym: alcohol drinking
has_related_synonym: alcohol use
id: ExO:0000104

race
type: Class
subclass of: Personal Attribute
definition: An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-06T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: human_attribute
has_related_synonym: racial group
id: ExO:0000109

African American
type: Class
subclass of: race
definition: A person having origins in any of the Black racial groups of Africa. Terms such as "Haitian" or "Negro" can be used in addition to "Black or African American".
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Black
has_related_synonym: Haitian
has_related_synonym: Negro
id: ExO:0000132

Alaska Native
type: Class
subclass of: race
definition: Denotes a person having origins in any indigenous people of Alaska and their descendants and who maintains tribal affiliation, or community or cultural attachment. The concept refers to population subgroups such as Eskimos, Aleuts, Inupiat, Yupik, Alutiiq, Egegik,and Pribilovian, Alaskan Athabascan, Tlingit, and Haida. The concept refers also to individuals who classify themselves as such.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Alaska Indian
has_related_synonym: Alaskan Athabascan
has_related_synonym: Aleut
has_related_synonym: Alutiq
has_related_synonym: Egegik
has_related_synonym: Eskimo
has_related_synonym: Haida
has_related_synonym: Inupiat
has_related_synonym: Pribilovian
has_related_synonym: Tlingit
has_related_synonym: Yupik
id: ExO:0000133

American Indian
type: Class
subclass of: race
definition: Denotes a person having origins in one of the indigenous peoples of North America, who lived on the continent prior to the European colonization. The term includes individuals belonging to a large number of tribes, states, and ethnic groups, many of them still enduring as communities.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
id: ExO:0000134

Asian
type: Class
subclass of: race
definition: A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, including for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
id: ExO:0000135

Asian Indian
type: Class
subclass of: race
definition: A person having origins in the original peoples of the Indian sub-continent.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Asian Indians
has_related_synonym: Indian
id: ExO:0000136

Central or South American
type: Class
subclass of: race
definition: A person of Central or South American culture or origin.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
has_obo_namespace: exposure_receptor
id: ExO:0000137

Chicano
type: Class
subclass of: race
definition: A term sometimes used interchangeably with Mexican-American to denote an American citizen of Mexican decent. The term is a chosen identity of some Mexican-Americans in the United States.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
has_obo_namespace: exposure_receptor
has_related_synonym: Mexican-American
id: ExO:0000138

Chinese
type: Class
subclass of: race
definition: A person having origins in any of the original peoples of China.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
id: ExO:0000139

Cuban
type: Class
subclass of: race
definition: A person of Cuban culture or origin, regardless of race.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Cuban-American
has_related_synonym: Hispanic
has_related_synonym: Latino
id: ExO:0000140

Cuban-American
type: Class
subclass of: race
definition: Denotes a person from or of Cuba or an American citizen of Cuban descent.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Cuban
id: ExO:0000141

Dominican
type: Class
subclass of: race
definition: Denotes the inhabitants of the Dominican Republic, a person from there, or their descendants elsewhere.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
id: ExO:0000142

Filipino
type: Class
subclass of: race
definition: A person having origins in any of the original peoples of the Philippine Islands.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
id: ExO:0000143

Guamanian
type: Class
subclass of: race
definition: Denotes inhabitants of Guam, an island in the North Pacific Ocean, about three-quarters of the way from Hawaii to the Philippines, south of the Northern Mariana Islands.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
has_obo_namespace: exposure_receptor
id: ExO:0000144

Hispanic
type: Class
subclass of: race
definition: A person of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Central American
has_related_synonym: Cuban
has_related_synonym: Latino
has_related_synonym: Mexican
has_related_synonym: Puerto Rican
has_related_synonym: South American
has_related_synonym: Spanish origin
id: ExO:0000145

Inuit
type: Class
subclass of: race
definition: A general term for a group of culturally similar indigenous peoples inhabiting the Arctic regions of Canada, Greenland, Russia and the United States. In Alaska, the term Eskimo is commonly used, because it includes both Yupik and Inupiat, while Inuit is not accepted as a collective term. In Canada and Greenland, the term Eskimo has fallen out of favor, as it is considered pejorative by the natives and has been replaced by the term Inuit.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Eskimo
id: ExO:0000146

Japanese
type: Class
subclass of: race
definition: A person having origins in any of the original peoples of Japan.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
id: ExO:0000147

Korean
type: Class
subclass of: race
definition: A person having origins in any of the original peoples of Korea.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
id: ExO:0000148

Latino
type: Class
subclass of: race
definition: A person of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Hispanic Spanish origin
has_related_synonym: Spanish origin
id: ExO:0000149

Mexican
type: Class
subclass of: race
definition: Denotes a person from or of Mexico.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Hispanic
id: ExO:0000150

Mexican-American
type: Class
subclass of: race
definition: Denotes an american citizen of Mexican descent.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
id: ExO:0000151

Native Hawaiian
type: Class
subclass of: race
definition: A person having origins in any of the original peoples of Hawaii.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Hawaiian
id: ExO:0000152

Other Race
type: Class
subclass of: race
definition: A person of non-specified racial, cultural, or geographic origins.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
has_obo_namespace: exposure_receptor
has_related_synonym: Other
id: ExO:0000153

Pacific Islander
type: Class
subclass of: race
definition: A person having origins in the original peoples of the Pacific Islands, but not Guam, Hawaii, the Mariana Islands or Samoa.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Other Pacific Islander
id: ExO:0000154

Puerto Rican
type: Class
subclass of: race
definition: A person of Puerto Rican descent.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
id: ExO:0000155

Samoan
type: Class
subclass of: race
definition: A person having origins in any of the original peoples of Samoa.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
id: ExO:0000156

Vietnamese
type: Class
subclass of: race
definition: A person having origins in any of the original peoples of Vietnam.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
has_obo_namespace: exposure_receptor
id: ExO:0000157

White
type: Class
subclass of: race
definition: A person having origins in any of the original peoples of Europe, the Middle East, or North Africa.
imported from: exo.owl
created by: cgrondin
creation date: 2017-04-07T03:47:29Z
database cross reference: https://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf
has_obo_namespace: exposure_receptor
has_related_synonym: Caucasian
has_related_synonym: Caucasians
has_related_synonym: Caucasoid
has_related_synonym: Occidental
has_related_synonym: Whites
id: ExO:0000158

Organ component
type: Class
subclass of: Cardinal organ part
definition: Cardinal organ part which is bounded predominantly by bonafide boundaries. Examples: lobe of lung, osteon, acinus, submucosa, anterior leaflet of mitral valve, capsule of kidney, cortical bone, muscle fasciculus.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:14065

Chemokine
type: Class
subclass of: Cytokine
imported from: fma.owl
has_obo_namespace: fma
id: FMA:241981

Region of cerebral cortex
type: Class
subclass of: Region of organ component
imported from: fma.owl
has_obo_namespace: fma
id: FMA:242193

Anatomical set
type: Class
subclass of: Anatomical structure
definition: Material anatomical entity which consists of the maximum number of discontinuous members of the same class. Examples: set of cranial nerves, ventral branches of aorta, set of mammary arteries, thoracic viscera, dental arcade.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:55652

Physical anatomical entity
type: Class
subclass of: anatomical entity
definition: Anatomical entity which has three or fewer spatial dimensions. Examples: hemoglobin molecule, mitochondrion, hepatocyte, erythrocyte, heart, head, blood, urine, peritoneal cavity, diaphragmatic surface of heart, inferior margin of liver, apex of lung.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:61775

Neurite
type: Class
subclass of: Cell appendage
definition: Cell appendage of the neuron which includes the axon and the dendrite.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:61814

Precuneus
type: Class
subclass of: Gyrus of neuraxis
imported from: fma.owl
has exact synonym: Precuneate lobule
has exact synonym: Quadrate lobule
has_obo_namespace: fma
id: FMA:61900

Cuneus
type: Class
subclass of: Gyrus of neuraxis
imported from: fma.owl
has exact synonym: Cuneate lobule
has exact synonym: Cuneus gyrus
has exact synonym: Cuneus of hemisphere
has_obo_namespace: fma
id: FMA:61903

Thalamus
type: Class
subclass of: Organ component of neuraxis
imported from: fma.owl
has exact synonym: Dorsal thalamus
has exact synonym: Dorsal thalamus (Anthoney)
has_obo_namespace: fma
id: FMA:62007

Hippocampus
type: Class
subclass of: Region of cerebral cortex
imported from: fma.owl
has exact synonym: Ammon's horn
has exact synonym: Hippocampus major
has exact synonym: Hippocampus proper
has_obo_namespace: fma
id: FMA:62493

B lymphocyte
type: Class
subclass of: lymphocyte
imported from: fma.owl
has exact synonym: B-lymphocyte
has_obo_namespace: fma
id: FMA:62869

T lymphocyte
type: Class
subclass of: lymphocyte
imported from: fma.owl
has exact synonym: T-lymphocyte
has_obo_namespace: fma
id: FMA:62870

Immunoglobulin
type: Class
subclass of: protein
imported from: fma.owl
has exact synonym: Antibody
has_obo_namespace: fma
id: FMA:62871

Fibril
type: Class
subclass of: cellular anatomical entity
definition: General anatomical term which refers to component of a fiber, e.g. collagen fibril or myofibril.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:62913

C1
type: Class
subclass of: Complement Component Protein
imported from: fma.owl
has_obo_namespace: fma
id: FMA:63493

Cytoskeleton
type: Class
subclass of: Anatomical structure
subclass of: organelle
imported from: fma.owl
has_obo_namespace: fma
id: FMA:63834

Plasma membrane
type: Class
subclass of: Anatomical structure
definition: Cell component which has as its parts a maximal phospholipids bilayer and two or more types of protein embedded in the bilayer. Examples: plasma membrane of hepatocyte, sarcolemma, plasma membrane of erythrocyte.
imported from: fma.owl
has exact synonym: Cell membrane
has exact synonym: Cellular membrane
has exact synonym: Cytoplasmic membrane
has exact synonym: Plasmalemma
has_obo_namespace: fma
id: FMA:63841

Biological macromolecule
type: Class
subclass of: Anatomical structure
definition: Anatomical structure which has as its parts one or more ordered aggregates of nucleotide, amino acid fatty acid or sugar molecules bonded to one another. Examples: collagen, DNA, neurotransmitter, troponin.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:63887

Cytoplasm
type: Class
subclass of: Anatomical structure
definition: Cell component which has as its direct parts a portion of cytosol and one or more organelles. Examples: cytoplasm of hepatocyte, cytoplasm of erythrocyte, cytoplasm of thrombocyte, cytoplasm of neuron.
imported from: fma.owl
has exact synonym: Cytoplasma
has_obo_namespace: fma
id: FMA:66835

Membrane of mitochondrion
type: Class
subclass of: Membrane layer of organelle
imported from: fma.owl
has exact synonym: Membrana mitochondrialis
has exact synonym: Mitochondrial membrane
has exact synonym: Mitochondrion membrane
has_obo_namespace: fma
id: FMA:66861

Anatomical structure
type: Class
subclass of: Material anatomical entity
definition: Material anatomical entity which is generated by coordinated expression of the organism's own genes that guide its morphogenesis; has inherent 3D shape; its parts are connected and spatially related to one another in patterns determined by coordinated gene expression. Examples: heart, right ventricle, mitral valve, myocardium, endothelium, lymphocyte, fibroblast, thorax, cardiovascular system, hemoglobin, T cell receptor.
imported from: fma.owl
has exact synonym: Biological structure
has_obo_namespace: fma
id: FMA:67135

Material anatomical entity
type: Class
subclass of: Physical anatomical entity
definition: Physical anatomical entity which has mass. Examples: hemoglobin molecule, mitochondrion, hepatocyte, erythrocyte, heart, head, blood, urine.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:67165

Cell body
type: Class
subclass of: Anatomical structure
definition: Cell component which consists of the plasma membrane and the cytoplasm surrounding the nucleus.
imported from: fma.owl
has exact synonym: Cell soma
has_obo_namespace: fma
id: FMA:67301

Cell appendage
type: Class
subclass of: Anatomical structure
definition: Cell component which consists of parts of the cytoplasm and plasma membrane protruding from the cell body. Examples: cilium, microvillus, axon.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:67304

Axon
type: Class
subclass of: Neurite
definition: Cell appendage of a neuron that consists of an axon hillock, an axon proper, axon collaterals and an axon terminal.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:67308

Dendrite
type: Class
subclass of: Neurite
definition: Cell appendage of a neuron that consists of the dendrite proper and the dendritic spines.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:67314

Organ region
type: Class
subclass of: Cardinal organ part
definition: Cardinal organ part which is a fiat subdivision of an organ. Examples: lingula of left lung, tail of pancreas, artery, trochanter, nodulus of semilunar valve, right side of heart, duodenum, fundus of stomach.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:67619

Protein complex
type: Class
subclass of: Biological macromolecule
imported from: fma.owl
has_obo_namespace: fma
id: FMA:67906

Cell
type: Class
subclass of: Anatomical structure
definition: Anatomical structure which has as its boundary the external surface of a maximally connected plasma membrane. Examples: lymphocyte, fibroblast, erythrocyte, neuron.
imported from: fma.owl
has exact synonym: Normal cell
has_obo_namespace: fma
id: FMA:68646

Preganglionic neuron
type: Class
subclass of: neuron
imported from: fma.owl
has exact synonym: Visceral efferent neuron
has_obo_namespace: fma
id: FMA:80122

Cardinal organ part
type: Class
subclass of: Anatomical structure
definition: anatomical structure which has as its direct parts two or more types of tissue and is continuous with one or more anatomical structures likewise constituted by two or more portions of tissues distinct from those of their complement. Examples: osteon, cortical bone, neck of femur, bronchopulmonary segment, left lobe of liver, anterior right side of heart, interventricular branch of left coronary artery, right atrium, mitral valve, head of pancreas.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:82472

Ventricle
type: Class
subclass of: organ component layer
definition: General anatomical term which refers to a chamber of an organ with cavitated organ parts. Examples: right ventricle of heart, lateral ventricle of brain.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:82553

Organ component of neuraxis
type: Class
subclass of: Organ component
definition: Organ component which is part of the brain or spinal cord.
imported from: fma.owl
has_obo_namespace: fma
id: FMA:83153

Gyrus of neuraxis
type: Class
subclass of: Organ segment
imported from: fma.owl
has exact synonym: Neuraxis gyrus
has_obo_namespace: fma
id: FMA:83874

Set of basal ganglia
type: Class
subclass of: Anatomical set
imported from: fma.owl
has exact synonym: Basal ganglia
has exact synonym: Basal ganglia set
has_obo_namespace: fma
id: FMA:84013

Cytokine
type: Class
subclass of: protein
imported from: fma.owl
has_obo_namespace: fma
id: FMA:84050

Membrane layer of organelle
type: Class
subclass of: Anatomical structure
imported from: fma.owl
has_obo_namespace: fma
id: FMA:85549

Region of organ component
type: Class
subclass of: Cardinal organ part
definition: Cardinal organ part which is a fiat subdivision of an organ component. Examples: cervical part of wall of esophagus, mucosa of body of stomach.
imported from: fma.owl
has exact synonym: Organ component region
has_obo_namespace: fma
id: FMA:86103

Organ segment
type: Class
subclass of: Organ region
definition: Organ region with one or more anchored fiat boundaries. Examples: artery, trunk of nerve, cervical part of esophagus, pelvic part of vagina, horn of thyroid cartilage, anterior segment of eyeball.
imported from: fma.owl
has exact synonym: Organ region with fixed fiat boundary
has exact synonym: Segment of organ
has_obo_namespace: fma
id: FMA:86140

Interleukin
type: Class
subclass of: Cytokine
imported from: fma.owl
has_obo_namespace: fma
id: FMA:86578

Interleukin-12
type: Class
subclass of: Interleukin
imported from: fma.owl
has exact synonym: IL-12
has_obo_namespace: fma
id: FMA:86579

invertebrate animal
type: Class
subclass of: material entity
example of usage: Familiar examples of invertebrates include arthropods (insects, arachnids, crustaceans, and myriapods), mollusks (chitons, snails, bivalves, squids, and octopuses), annelids (earthworms and leeches), and cnidarians (hydras, jellyfishes, sea anemones, and corals).[wikipedia]
has curation status: IAO_0000122
definition: Invertebrates are animals that neither possess nor develop a vertebral column (commonly known as a backbone or spine), derived from the notochord. This includes all animals apart from the subphylum Vertebrata.
definition editor: Damion Dooley
definition source: https://en.wikipedia.org/wiki/Invertebrate
imported from: foodon.owl
has_broad_synonym: animal

fragmented DNA
type: Class
subclass of: intracellular anatomical structure
definition: A cell phenotype in which DNA is broken into small fragments.
imported from: fypo.owl
created by: midori
creation date: 2011-04-19T02:59:38Z
has exact synonym: DNA fragmentation
has_obo_namespace: fission_yeast_phenotype
has_related_synonym: fragmented nucleus
id: FYPO:0000160
comment: Use 'fragmented DNA' (FYPO:0000160) or one of its descendants if DNA was detected using a method that can resolve molecule sizes (e.g. gel electrophoresis) or detect DNA ends (e.g. TUNEL assay). Otherwise, consider using 'fragmented nucleus' (FYPO:0001919) or one of its descendants.

gender
type: Class
subclass of: quality
IHCC category: socio-demographic and economic characteristics
IHCC browser label: gender
definition: An organismal quality inhering in a bearer by virtue of the bearer's preference towards a range of characteristics pertaining to, and differentiating between, masculinity and femininity.
definition source: Wikipedia:Gender|PATO:0000047
imported from: gecko.owl

cognitive measurement
type: Class
subclass of: measurement datum
IHCC category: cognitive and psychological measurements
IHCC browser label: cognitive functioning
definition: A psychological measurement of some aspect of intellectual functions such as memory, problem solving, and comprehension.
definition source: Wikipedia:Cognition
imported from: gecko.owl

Alzheimer's Disease Assessment Scale score
type: Class
subclass of: cognitive measurement
subclass of: Restriction
  on property: isClinicalMarkerFor
  some values from: Alzheimer's disease
IHCC category: cognitive functioning
IHCC browser label: ADAS
definition: A cognitive measurement that is an output (score) from the Alzheimer's Disease Assessment Scale.
imported from: gecko.owl

Mini-Mental State Exam score
type: Class
subclass of: cognitive measurement
subclass of: Restriction
  on property: isClinicalMarkerFor
  some values from: Alzheimer's disease
IHCC category: cognitive functioning
IHCC browser label: MMSE
definition: A cognitive measurement that is an output (score) from the Mini-Mental State Exam.
imported from: gecko.owl

Montreal Cognitive Assessment Test score
type: Class
subclass of: cognitive measurement
subclass of: Restriction
  on property: isClinicalMarkerFor
  some values from: Alzheimer's disease
IHCC category: cognitive functioning
IHCC browser label: MoCA
definition: A cognitive measurement that is the output (score) from the Montreal Cognitive Assessment Test (MoCA) for Dementia
imported from: gecko.owl

Clinical Dementia Rating Scale score
type: Class
subclass of: cognitive measurement
subclass of: Restriction
  on property: isClinicalMarkerFor
  some values from: Alzheimer's disease
IHCC category: cognitive functioning
IHCC browser label: CDR
definition: A cognitive measurement that is the output (score) from the Clinical Dementia Rating Scale.
imported from: gecko.owl

diagnostic test
type: Class
subclass of: planned process
has curation status: IAO_0000428
definition editor: Damion Dooley
imported from: genepio.owl

danio rerio gene
type: Class
subclass of: gene
definition: A gene that originates from the genome of a danio rerio.
imported from: geno.owl

mutation
type: Class
subclass of: disposition
definition: A sequence alteration that is very rare allele in a population (typically <1%), or an experimentally-induced variation that derives from a wild-type feature in a given strain.
imported from: geno.owl

Golgi membrane
type: Class
subclass of: bounding membrane of organelle
definition: The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
imported from: go.owl
has_obo_namespace: cellular_component
id: GO:0000139

MAPK cascade
type: Class
subclass of: signal transduction
definition: An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
imported from: go.owl
has_alternative_id: GO:0007255
database cross reference: Wikipedia:MAPK_cascade
database cross reference: Wikipedia:Mitogen-activated_protein_kinase
has exact synonym: MAP kinase cascade
has exact synonym: MAP kinase kinase kinase cascade
has exact synonym: MAPK signal transduction
has exact synonym: MAPKKK cascade
has exact synonym: mitogen-activated protein kinase cascade
has_narrow_synonym: ERK/MAPK cascade
has_narrow_synonym: MAPKKK cascade during sporulation
has_obo_namespace: biological_process
has_related_synonym: MAPK signaling
has_related_synonym: MAPK signalling
id: GO:0000165
comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.

autophagy of mitochondrion
type: Class
subclass of: autophagy
definition: The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions.
imported from: go.owl
database cross reference: Wikipedia:Autophagy_(cellular)#Selective_autophagy
database cross reference: Wikipedia:Mitophagy
has exact synonym: mitochondrion autophagy
has_obo_namespace: biological_process
has_related_synonym: mitophagy
id: GO:0000422

mitophagy
type: Class
subclass of: autophagy
definition: The selective autophagy process in which a mitochondrion is degraded by macroautophagy.
imported from: go.owl
has exact synonym: macromitophagy
has_obo_namespace: biological_process
id: GO:0000423
comment: Note that this terms refers to the macroautophagy process and is named by common usage. Be aware that there are a separate micromitophagy and mitophagy by induced vacuole formation processes.

proteasome complex
type: Class
subclass of: catalytic complex
definition: A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.
imported from: fypo.owl
has exact synonym: proteasome
has_narrow_synonym: 26S proteasome
has_obo_namespace: cellular_component
id: GO:0000502
in subset: goslim pir

action potential
type: Class
subclass of: biological regulation
definition: A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
imported from: go.owl
never in taxon: NCBITaxon 4895
has_obo_namespace: biological_process
id: GO:0001508
comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so.

microglial cell activation
type: Class
subclass of: cellular process
definition: The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
imported from: go.owl
has_obo_namespace: biological_process
id: GO:0001774

immune system process
type: Class
subclass of: biological_process
definition: Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
imported from: go.owl
never in taxon: NCBITaxon 4895
database cross reference: Wikipedia:Immune_system
has_obo_namespace: biological_process
id: GO:0002376
in subset: goslim agr
in subset: goslim chembl
in subset: goslim flybase ribbon
in subset: goslim generic
in subset: goslim mouse
in subset: goslim pir
comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501).

cellular_component
type: Class
subclass of: material entity
definition: A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome).
imported from: go.owl
has_alternative_id: GO:0008372
database cross reference: NIF_Subcellular:sao1337158144
has exact synonym: cell or subcellular entity
has exact synonym: cellular component
has_obo_namespace: cellular_component
has_related_synonym: subcellular entity
id: GO:0005575
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim plant
in subset: goslim yeast
comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.

fibrinogen complex
type: Class
subclass of: protein-containing complex
definition: A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.
imported from: go.owl
has exact synonym: fibrinogen
has_narrow_synonym: fibrinogen alpha chain
has_narrow_synonym: fibrinogen beta chain
has_narrow_synonym: fibrinogen gamma chain
has_obo_namespace: cellular_component
id: GO:0005577

membrane attack complex
type: Class
subclass of: pore complex
subclass of: plasma membrane protein complex
definition: A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
imported from: go.owl
database cross reference: Wikipedia:Complement_membrane_attack_complex
has exact synonym: MAC
has exact synonym: TCC
has exact synonym: terminal complement complex
has_narrow_synonym: membrane attack complex protein alphaM chain
has_narrow_synonym: membrane attack complex protein beta2 chain
has_obo_namespace: cellular_component
id: GO:0005579

intracellular anatomical structure
type: Class
subclass of: cellular anatomical entity
definition: A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
term tracker item: https://github.com/geneontology/go-ontology/issues/17776
imported from: go.owl
database cross reference: Wikipedia:Intracellular
has exact synonym: internal to cell
has exact synonym: intracellular
has exact synonym: protoplasm
has_obo_namespace: cellular_component
has_related_synonym: nucleocytoplasm
has_related_synonym: protoplast
id: GO:0005622
in subset: gocheck do not annotate
in subset: goslim chembl
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim plant

nucleus
type: Class
subclass of: organelle
definition: A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
imported from: go.owl
database cross reference: NIF_Subcellular:sao1702920020
database cross reference: Wikipedia:Cell_nucleus
has exact synonym: cell nucleus
has_narrow_synonym: horsetail nucleus
has_obo_namespace: cellular_component
id: GO:0005634
in subset: goslim agr
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim flybase ribbon
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim mouse
in subset: goslim pir
in subset: goslim plant
in subset: goslim yeast

mitochondrion
type: Class
subclass of: organelle
definition: A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
imported from: go.owl
database cross reference: NIF_Subcellular:sao1860313010
database cross reference: Wikipedia:Mitochondrion
has exact synonym: mitochondria
has_obo_namespace: cellular_component
id: GO:0005739
in subset: goslim agr
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim flybase ribbon
in subset: goslim generic
in subset: goslim mouse
in subset: goslim pir
in subset: goslim plant
in subset: goslim yeast
comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)

lysosome
type: Class
subclass of: vacuole
definition: A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
imported from: go.owl
never in taxon: NCBITaxon 4751
database cross reference: NIF_Subcellular:sao585356902
database cross reference: Wikipedia:Lysosome
has_obo_namespace: cellular_component
id: GO:0005764
in subset: goslim chembl
in subset: goslim generic
in subset: goslim plant

endosome
type: Class
subclass of: organelle
definition: A vacuole to which materials ingested by endocytosis are delivered.
imported from: go.owl
database cross reference: NIF_Subcellular:sao1720343330
database cross reference: Wikipedia:Endosome
has_obo_namespace: cellular_component
id: GO:0005768
in subset: goslim agr
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim generic
in subset: goslim mouse
in subset: goslim pir
in subset: goslim plant

early endosome
type: Class
subclass of: endosome
definition: A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
imported from: go.owl
database cross reference: NIF_Subcellular:nlx_subcell_20090701
has_obo_namespace: cellular_component
id: GO:0005769

late endosome
type: Class
subclass of: endosome
definition: A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
imported from: go.owl
has_broad_synonym: PVC
database cross reference: NIF_Subcellular:nlx_subcell_20090702
has exact synonym: prevacuolar compartment
has_obo_namespace: cellular_component
id: GO:0005770

vacuole
type: Class
subclass of: organelle
definition: A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
imported from: go.owl
database cross reference: Wikipedia:Vacuole
has_obo_namespace: cellular_component
has_related_synonym: vacuolar carboxypeptidase Y
id: GO:0005773
in subset: goslim agr
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim flybase ribbon
in subset: goslim generic
in subset: goslim mouse
in subset: goslim pir
in subset: goslim plant
in subset: goslim yeast

autophagosome
type: Class
subclass of: vacuole
definition: A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
imported from: go.owl
database cross reference: NIF_Subcellular:sao8663416959
has exact synonym: autophagic vacuole
has_obo_namespace: cellular_component
has_related_synonym: initial autophagic vacuole
id: GO:0005776

endoplasmic reticulum
type: Class
subclass of: organelle
definition: The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
imported from: go.owl
database cross reference: NIF_Subcellular:sao1036339110
database cross reference: Wikipedia:Endoplasmic_reticulum
has exact synonym: ER
has_obo_namespace: cellular_component
id: GO:0005783
in subset: goslim agr
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim generic
in subset: goslim mouse
in subset: goslim pir
in subset: goslim plant
in subset: goslim yeast

Golgi apparatus
type: Class
subclass of: organelle
definition: A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
imported from: go.owl
has_broad_synonym: Golgi
database cross reference: NIF_Subcellular:sao451912436
database cross reference: Wikipedia:Golgi_apparatus
has exact synonym: Golgi complex
has_narrow_synonym: Golgi ribbon
has_obo_namespace: cellular_component
id: GO:0005794
in subset: goslim agr
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim generic
in subset: goslim mouse
in subset: goslim pir
in subset: goslim plant
in subset: goslim yeast
comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon.

trans-Golgi network
type: Class
subclass of: organelle subcompartment
definition: The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
imported from: go.owl
has_broad_synonym: trans face
database cross reference: NIF_Subcellular:sao9456487
has exact synonym: TGN
has exact synonym: trans Golgi network
has_obo_namespace: cellular_component
has_related_synonym: Golgi trans face
has_related_synonym: Golgi trans-face
has_related_synonym: late Golgi
has_related_synonym: maturing face
id: GO:0005802
comment: There are different opinions about whether the TGN should be considered part of the Golgi apparatus or not. We follow Alberts et al, 1994 (ISBN:0815316194), who consider it to be a part.

microtubule
type: Class
subclass of: supramolecular complex
definition: Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
imported from: go.owl
database cross reference: NIF_Subcellular:sao1846835077
database cross reference: Wikipedia:Microtubule
has exact synonym: microtubuli
has exact synonym: microtubulus
has_narrow_synonym: neurotubule
has_obo_namespace: cellular_component
id: GO:0005874
in subset: goslim metagenomics

tricarboxylic acid cycle
type: Class
subclass of: cellular metabolic process
definition: A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
imported from: go.owl
database cross reference: MetaCyc:P105-PWY
database cross reference: MetaCyc:P42-PWY
database cross reference: MetaCyc:TCA
database cross reference: Wikipedia:Tricarboxylic_acid_cycle
has exact synonym: Krebs cycle
has exact synonym: TCA cycle
has exact synonym: citric acid cycle
has_obo_namespace: biological_process
id: GO:0006099

DNA replication
type: Class
subclass of: cellular metabolic process
definition: The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
imported from: go.owl
has_alternative_id: GO:0055133
database cross reference: Wikipedia:DNA_replication
has_obo_namespace: biological_process
id: GO:0006260
in subset: goslim drosophila
in subset: goslim pir
in subset: goslim pombe
in subset: goslim yeast
comment: DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'.

transcription, DNA-templated
type: Class
subclass of: cellular metabolic process
definition: The cellular synthesis of RNA on a template of DNA.
imported from: go.owl
has_alternative_id: GO:0006350
has_alternative_id: GO:0061018
has_alternative_id: GO:0061022
has_broad_synonym: cellular transcription
has_broad_synonym: transcription
database cross reference: Wikipedia:Transcription_(genetics)
has exact synonym: DNA-dependent transcription
has exact synonym: cellular transcription, DNA-dependent
has exact synonym: transcription, DNA-dependent
has_obo_namespace: biological_process
has_related_synonym: transcription regulator activity
id: GO:0006351
in subset: goslim aspergillus
in subset: goslim drosophila
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim pombe

translation
type: Class
subclass of: cellular metabolic process
definition: The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
imported from: go.owl
has_alternative_id: GO:0006416
has_alternative_id: GO:0006453
has_alternative_id: GO:0043037
database cross reference: Wikipedia:Translation_(genetics)
has exact synonym: protein anabolism
has exact synonym: protein biosynthesis
has exact synonym: protein biosynthetic process
has exact synonym: protein formation
has exact synonym: protein synthesis
has exact synonym: protein translation
has_obo_namespace: biological_process
id: GO:0006412
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim plant

transport
type: Class
subclass of: localization
definition: The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein.
imported from: go.owl
created by: jl
creation date: 2012-12-13T16:25:32Z
has_alternative_id: GO:0015457
has_alternative_id: GO:0015460
has_alternative_id: GO:0044765
has_narrow_synonym: small molecule transport
has_narrow_synonym: solute:solute exchange
has_obo_namespace: biological_process
has_related_synonym: single-organism transport
id: GO:0006810
in subset: gocheck do not annotate
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim plant
comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport.

ion transport
type: Class
subclass of: localization
definition: The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
imported from: go.owl
has_obo_namespace: biological_process
id: GO:0006811
in subset: goslim drosophila
in subset: goslim pir
in subset: goslim yeast

sodium ion transport
type: Class
subclass of: ion transport
definition: The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
imported from: go.owl
has_alternative_id: GO:0006834
has_alternative_id: GO:0016974
has_broad_synonym: sodium/potassium transport
has exact synonym: sodium transport
has_narrow_synonym: mitochondrial sodium/calcium ion exchange
has_narrow_synonym: sodium:calcium exchange
has_narrow_synonym: sodium:solute transport
has_obo_namespace: biological_process
has_related_synonym: sodium channel auxiliary protein activity
id: GO:0006814

lipid transport
type: Class
subclass of: transport
definition: The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
imported from: go.owl
has_obo_namespace: biological_process
id: GO:0006869
in subset: goslim drosophila
in subset: goslim pir
in subset: goslim yeast

exocytosis
type: Class
subclass of: vesicle-mediated transport
definition: A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
imported from: go.owl
has_alternative_id: GO:0016194
has_alternative_id: GO:0016195
database cross reference: Wikipedia:Exocytosis
has exact synonym: vesicle exocytosis
has_obo_namespace: biological_process
has_related_synonym: nonselective vesicle exocytosis
id: GO:0006887
in subset: goslim yeast

endocytosis
type: Class
subclass of: vesicle-mediated transport
definition: A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
imported from: go.owl
has_alternative_id: GO:0016193
has_alternative_id: GO:0016196
has_alternative_id: GO:0098701
database cross reference: Wikipedia:Endocytosis
has exact synonym: endocytic import into cell
has exact synonym: vesicle endocytosis
has_narrow_synonym: plasma membrane invagination
has_obo_namespace: biological_process
has_related_synonym: nonselective vesicle endocytosis
id: GO:0006897
in subset: goslim yeast

phagocytosis
type: Class
subclass of: vesicle-mediated transport
definition: A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
imported from: go.owl
never in taxon: NCBITaxon 4751
database cross reference: Wikipedia:Phagocytosis
has_obo_namespace: biological_process
id: GO:0006909

autophagy
type: Class
subclass of: cellular process
definition: The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
imported from: go.owl
has_alternative_id: GO:0016238
database cross reference: Wikipedia:Autophagy_(cellular)
has_obo_namespace: biological_process
id: GO:0006914
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim generic
in subset: goslim pir
in subset: goslim pombe

chemotaxis
type: Class
subclass of: biological_process
definition: The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
imported from: go.owl
database cross reference: Wikipedia:Chemotaxis
has exact synonym: taxis in response to chemical stimulus
has_obo_namespace: biological_process
id: GO:0006935

immune response
type: Class
subclass of: immune system process
subclass of: response to stimulus
definition: Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
imported from: go.owl
has_obo_namespace: biological_process
id: GO:0006955
in subset: goslim drosophila

plasma membrane organization
type: Class
subclass of: cellular process
definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
imported from: go.owl
has exact synonym: plasma membrane organisation
has_obo_namespace: biological_process
has_related_synonym: plasma membrane organization and biogenesis
id: GO:0007009
in subset: goslim chembl
in subset: goslim generic

cell communication
type: Class
subclass of: cellular process
definition: Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
imported from: go.owl
database cross reference: Wikipedia:Cell_signaling
has_obo_namespace: biological_process
id: GO:0007154
in subset: goslim pir
in subset: goslim plant

cell adhesion
type: Class
subclass of: biological adhesion
definition: The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
imported from: go.owl
created by: dos
creation date: 2014-04-15T15:59:10Z
has_alternative_id: GO:0098602
database cross reference: Wikipedia:Cell_adhesion
has_obo_namespace: biological_process
has_related_synonym: cell adhesion molecule activity
has_related_synonym: single organism cell adhesion
id: GO:0007155
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim pombe

signal transduction
type: Class
subclass of: cellular process
definition: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
imported from: go.owl
has_alternative_id: GO:0023014
has_alternative_id: GO:0023015
has_alternative_id: GO:0023016
has_alternative_id: GO:0023033
has_alternative_id: GO:0023045
database cross reference: MIPS_funcat:30
database cross reference: Wikipedia:Signal_transduction
has_narrow_synonym: signal transduction by cis-phosphorylation
has_narrow_synonym: signal transduction by conformational transition
has_narrow_synonym: signal transduction by protein phosphorylation
has_narrow_synonym: signal transduction by trans-phosphorylation
has_narrow_synonym: signaling cascade
has_narrow_synonym: signalling cascade
has_obo_namespace: biological_process
has_related_synonym: signaling pathway
has_related_synonym: signalling pathway
id: GO:0007165
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim plant
comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.

Notch signaling pathway
type: Class
subclass of: signal transduction
definition: A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
imported from: go.owl
never in taxon: NCBITaxon 4751
has_alternative_id: GO:0030179
database cross reference: Wikipedia:Notch_signaling_pathway
has exact synonym: N signaling pathway
has exact synonym: N signalling pathway
has exact synonym: Notch receptor signaling pathway
has exact synonym: Notch receptor signalling pathway
has exact synonym: Notch signalling pathway
has exact synonym: Notch-receptor signaling pathway
has exact synonym: Notch-receptor signalling pathway
has_obo_namespace: biological_process
id: GO:0007219

chemical synaptic transmission
type: Class
subclass of: cellular process
definition: The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
imported from: go.owl
has_broad_synonym: signal transmission across a synapse
has_broad_synonym: synaptic transmission
database cross reference: Wikipedia:Neurotransmission
has_obo_namespace: biological_process
has_related_synonym: neurotransmission
id: GO:0007268
in subset: goslim synapse

behavior
type: Class
subclass of: bodily process
definition: The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.
imported from: go.owl
created by: janelomax
creation date: 2012-09-20T14:06:08Z
has_alternative_id: GO:0044708
database cross reference: Wikipedia:Behavior
has exact synonym: behavioral response to stimulus
has exact synonym: behaviour
has exact synonym: behavioural response to stimulus
has_obo_namespace: biological_process
has_related_synonym: single-organism behavior
id: GO:0007610
in subset: gocheck do not manually annotate
in subset: goslim agr
in subset: goslim flybase ribbon
comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. 2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis).

synaptic vesicle
type: Class
subclass of: organelle
definition: A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
imported from: go.owl
database cross reference: NIF_Subcellular:sao1071221672
database cross reference: Wikipedia:Synaptic_vesicle
has_narrow_synonym: docked vesicle
has_obo_namespace: cellular_component
id: GO:0008021
in subset: goslim synapse
comment: This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles.

biological_process
type: Class
subclass of: process
definition: A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
imported from: go.owl
created by: janelomax
created by: jl
creation date: 2012-09-19T15:05:24Z
has_alternative_id: GO:0000004
has_alternative_id: GO:0007582
has_alternative_id: GO:0044699
database cross reference: Wikipedia:Biological_process
has exact synonym: biological process
has exact synonym: physiological process
has_obo_namespace: biological_process
has_related_synonym: single organism process
has_related_synonym: single-organism process
id: GO:0008150
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim generic
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim plant
in subset: goslim pombe
in subset: goslim yeast
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this.
comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this.

metabolic process
type: Class
subclass of: biological_process
definition: The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
imported from: go.owl
created by: jl
creation date: 2012-10-17T15:46:40Z
has_alternative_id: GO:0044236
has_alternative_id: GO:0044710
database cross reference: Wikipedia:Metabolism
has exact synonym: metabolism
has_narrow_synonym: metabolic process resulting in cell growth
has_narrow_synonym: metabolism resulting in cell growth
has_narrow_synonym: multicellular organism metabolic process
has_obo_namespace: biological_process
has_related_synonym: single-organism metabolic process
id: GO:0008152
in subset: gocheck do not manually annotate
in subset: goslim chembl
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim plant
comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions.

cell death
type: Class
subclass of: cellular process
definition: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
imported from: go.owl
has_obo_namespace: biological_process
has_related_synonym: accidental cell death
has_related_synonym: necrosis
id: GO:0008219
in subset: goslim agr
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim generic
in subset: goslim mouse
in subset: goslim plant
comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.

catabolic process
type: Class
subclass of: metabolic process
definition: The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
imported from: go.owl
created by: jl
creation date: 2012-10-17T15:52:35Z
has_alternative_id: GO:0044243
has_alternative_id: GO:0044712
database cross reference: Wikipedia:Catabolism
has exact synonym: breakdown
has exact synonym: catabolism
has exact synonym: degradation
has_narrow_synonym: multicellular organismal catabolic process
has_obo_namespace: biological_process
has_related_synonym: single-organism catabolic process
id: GO:0009056
in subset: goslim agr
in subset: goslim chembl
in subset: goslim generic
in subset: goslim plant

cellular process
type: Class
subclass of: biological_process
subclass of: Restriction
  on property: isCellularProcessFor
  some values from: Alzheimer's disease
definition: Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
imported from: go.owl
created by: janelomax
created by: jl
creation date: 2012-12-11T16:56:55Z
has_alternative_id: GO:0008151
has_alternative_id: GO:0044763
has_alternative_id: GO:0050875
has exact synonym: cell physiology
has exact synonym: cellular physiological process
has_narrow_synonym: cell growth and/or maintenance
has_obo_namespace: biological_process
has_related_synonym: single-organism cellular process
id: GO:0009987
in subset: goslim plant

endosome membrane
type: Class
subclass of: cytoplasmic vesicle membrane
subclass of: bounding membrane of organelle
definition: The lipid bilayer surrounding an endosome.
imported from: go.owl
database cross reference: NIF_Subcellular:sao978443756
has exact synonym: endosomal membrane
has_obo_namespace: cellular_component
id: GO:0010008

regulation of gene expression
type: Class
subclass of: biological regulation
definition: Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
term tracker item: https://github.com/geneontology/go-ontology/issues/22557
imported from: go.owl
database cross reference: Wikipedia:Regulation_of_gene_expression
has_narrow_synonym: regulation of protein expression
has_obo_namespace: biological_process
has_related_synonym: gene regulation
has_related_synonym: regulation of gene product expression
id: GO:0010468
comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation.

vesicle membrane
type: Class
subclass of: organelle membrane
definition: The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
imported from: go.owl
database cross reference: NIF_Subcellular:sao1153182838
has_obo_namespace: cellular_component
id: GO:0012506

postsynaptic density
type: Class
subclass of: organelle
definition: An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
imported from: go.owl
created by: pr
creation date: 2013-07-02T09:44:28Z
has_alternative_id: GO:0097481
has_alternative_id: GO:0097483
database cross reference: NIF_Subcellular:sao1196688972
database cross reference: Wikipedia:Postsynaptic_density
has exact synonym: neuronal postsynaptic density
has exact synonym: post synaptic density
has exact synonym: post-synaptic density
has_narrow_synonym: postsynaptic density of dendrite
has_obo_namespace: cellular_component
id: GO:0014069
in subset: goslim synapse

phospholipid transport
type: Class
subclass of: transport
definition: The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
imported from: go.owl
has_obo_namespace: biological_process
id: GO:0015914

membrane
type: Class
subclass of: cellular anatomical entity
definition: A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
imported from: go.owl
creation date: 2014-03-06T11:37:54Z
has_alternative_id: GO:0098589
has_alternative_id: GO:0098805
database cross reference: Wikipedia:Biological_membrane
has_narrow_synonym: membrane region
has_narrow_synonym: region of membrane
has_narrow_synonym: whole membrane
has_obo_namespace: cellular_component
id: GO:0016020
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim flybase ribbon
in subset: goslim metagenomics
in subset: goslim pir
in subset: goslim plant
in subset: goslim yeast

vesicle-mediated transport
type: Class
subclass of: cellular process
definition: A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
imported from: go.owl
has_alternative_id: GO:0006899
has exact synonym: vesicle transport
has exact synonym: vesicular transport
has_narrow_synonym: nonselective vesicle transport
has_obo_namespace: biological_process
has_related_synonym: protein sorting along secretory pathway
has_related_synonym: vesicle trafficking
id: GO:0016192
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim generic
in subset: goslim pir
in subset: goslim pombe

inclusion body
type: Class
subclass of: intracellular anatomical structure
definition: A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.
imported from: go.owl
database cross reference: NIF_Subcellular:sao120573470
database cross reference: Wikipedia:Inclusion_bodies
has_narrow_synonym: neuronal cytoplasmic inclusion
has_obo_namespace: cellular_component
has_related_synonym: cellular inclusion
id: GO:0016234

phosphorylation
type: Class
subclass of: cellular process
definition: The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
imported from: go.owl
database cross reference: Wikipedia:Phosphorylation
has_obo_namespace: biological_process
id: GO:0016310
in subset: goslim chembl
in subset: goslim metagenomics

dephosphorylation
type: Class
subclass of: cellular process
definition: The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
imported from: go.owl
database cross reference: Wikipedia:Dephosphorylation
has_obo_namespace: biological_process
id: GO:0016311

protein sumoylation
type: Class
subclass of: cellular process
definition: The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
imported from: go.owl
has_alternative_id: GO:0006485
has_alternative_id: GO:0016927
database cross reference: Wikipedia:SUMO_protein
has exact synonym: SUMO-protein conjugation
has exact synonym: protein sumolation
has exact synonym: small ubiquitin-related protein 1 conjugation
has exact synonym: sumoylation
has_obo_namespace: biological_process
id: GO:0016925

protein myristoylation
type: Class
subclass of: cellular metabolic process
definition: The covalent attachment of a myristoyl group to a protein.
imported from: go.owl
has_alternative_id: GO:0018319
has exact synonym: protein amino acid myristoylation
has_obo_namespace: biological_process
id: GO:0018377

calcium-mediated signaling
type: Class
subclass of: signal transduction
definition: Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
imported from: go.owl
database cross reference: Wikipedia:Calcium_signaling
has exact synonym: calcium ion signaling
has exact synonym: calcium signaling
has exact synonym: calcium signalling
has exact synonym: calcium-mediated signalling
has_obo_namespace: biological_process
id: GO:0019722

cell cycle process
type: Class
subclass of: cellular process
definition: The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
imported from: go.owl
has_obo_namespace: biological_process
id: GO:0022402
in subset: gocheck do not annotate

cell cycle phase
type: Class
subclass of: biological phase
definition: One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.
imported from: go.owl
has_obo_namespace: biological_process
id: GO:0022403
in subset: gocheck do not annotate
comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during).

biological adhesion
type: Class
subclass of: biological_process
definition: The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions.
imported from: go.owl
has_obo_namespace: biological_process
id: GO:0022610
in subset: goslim pir

signaling
type: Class
subclass of: biological_process
definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
imported from: go.owl
created by: jl
creation date: 2010-02-16T09:30:50Z
has_alternative_id: GO:0023046
has_alternative_id: GO:0044700
has exact synonym: biological signaling
has exact synonym: signaling process
has exact synonym: signalling
has_obo_namespace: biological_process
has_related_synonym: signalling process
has_related_synonym: single organism signaling
id: GO:0023052
in subset: goslim agr
in subset: goslim flybase ribbon
in subset: goslim mouse
in subset: goslim pombe
in subset: goslim yeast
comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change.

cell junction
type: Class
subclass of: cellular anatomical entity
definition: A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.
imported from: go.owl
never in taxon: NCBITaxon 4751
database cross reference: Wikipedia:Cell_junction
has_obo_namespace: cellular_component
id: GO:0030054
in subset: goslim agr
in subset: goslim drosophila
in subset: goslim flybase ribbon

external encapsulating structure
type: Class
subclass of: cellular anatomical entity
definition: A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.
imported from: go.owl
has_obo_namespace: cellular_component
id: GO:0030312
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim generic
in subset: goslim pir
in subset: goslim plant
comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'.

growth cone
type: Class
subclass of: site of polarized growth
definition: The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
imported from: go.owl
database cross reference: Wikipedia:Growth_cone
has_obo_namespace: cellular_component
id: GO:0030426

site of polarized growth
type: Class
subclass of: cellular anatomical entity
definition: Any part of a cell where non-isotropic growth takes place.
imported from: go.owl
has_alternative_id: GO:0000134
has_alternative_id: GO:0030483
has_obo_namespace: cellular_component
id: GO:0030427
in subset: goslim aspergillus
in subset: goslim candida
in subset: goslim pir
in subset: goslim yeast

cytoplasmic vesicle membrane
type: Class
subclass of: vesicle membrane
definition: The lipid bilayer surrounding a cytoplasmic vesicle.
imported from: go.owl
has_obo_namespace: cellular_component
id: GO:0030659

extracellular matrix
type: Class
subclass of: external encapsulating structure
definition: A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
imported from: go.owl
has_alternative_id: GO:0005578
database cross reference: NIF_Subcellular:nlx_subcell_20090513
database cross reference: Wikipedia:Extracellular_matrix
has exact synonym: proteinaceous extracellular matrix
has_narrow_synonym: matrisome
has_obo_namespace: cellular_component
id: GO:0031012
in subset: goslim chembl
in subset: goslim drosophila
in subset: goslim generic
in subset: goslim pir

organelle membrane
type: Class
subclass of: membrane
definition: A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
imported from: go.owl
database cross reference: NIF_Subcellular:sao830981606
has_obo_namespace: cellular_component
has_related_synonym: intracellular membrane
id: GO:0031090

nuclear membrane
type: Class
subclass of: organelle membrane
definition: Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
imported from: go.owl
database cross reference: NIF_Subcellular:sao1687101204
has_obo_namespace: cellular_component
id: GO:0031965

mitochondrial membrane
type: Class
subclass of: organelle membrane
definition: Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
imported from: go.owl
database cross reference: NIF_Subcellular:sao1045389829
has_obo_namespace: cellular_component
id: GO:0031966

organelle subcompartment
type: Class
subclass of: cellular anatomical entity
definition: A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle.
imported from: go.owl
has exact synonym: suborganelle compartment
has_obo_namespace: cellular_component
id: GO:0031984
comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles.

methylation
type: Class
subclass of: metabolic process
definition: The process in which a methyl group is covalently attached to a molecule.
imported from: go.owl
database cross reference: Wikipedia:Methylation
has_obo_namespace: biological_process
id: GO:0032259
in subset: goslim chembl

neuronal cell body membrane
type: Class
subclass of: membrane
definition: The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
imported from: go.owl
has exact synonym: neuron cell body membrane
has exact synonym: neuronal cell soma membrane
has_obo_namespace: cellular_component
id: GO:0032809

protein-containing complex
type: Class
subclass of: cellular_component
definition: A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
imported from: go.owl
has_alternative_id: GO:0043234
has exact synonym: macromolecular complex
has exact synonym: macromolecule complex
has exact synonym: protein containing complex
has_narrow_synonym: protein complex
has_narrow_synonym: protein-protein complex
has_obo_namespace: cellular_component
id: GO:0032991
in subset: goslim agr
in subset: goslim chembl
in subset: goslim flybase ribbon
in subset: goslim generic
in subset: goslim pir
comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole.

protein-DNA complex
type: Class
subclass of: protein-containing complex
definition: A macromolecular complex containing both protein and DNA molecules.
imported from: go.owl
has exact synonym: DNA-protein complex
has_obo_namespace: cellular_component
id: GO:0032993
in subset: goslim pir
comment: Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here.

node of Ranvier
type: Class
subclass of: cellular anatomical entity
definition: An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
imported from: go.owl
database cross reference: NIF_Subcellular:birnlex_1152_2
database cross reference: Wikipedia:Nodes_of_Ranvier
has_obo_namespace: cellular_component
has_related_synonym: node of Ranvier axon
id: GO:0033268

ionotropic glutamate receptor binding
type: Class
subclass of: cellular process
definition: Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
imported from: go.owl
has_obo_namespace: molecular_function
id: GO:0035255

protein modification process
type: Class
subclass of: metabolic process
definition: The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
imported from: go.owl
created by: bf
creation date: 2012-04-26T01:47:12Z
has exact synonym: protein modification
has_obo_namespace: biological_process
id: GO:0036211

synaptic vesicle recycling
type: Class
subclass of: cellular process
definition: The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane.
imported from: go.owl
created by: bf
creation date: 2014-06-26T11:03:08Z
has_narrow_synonym: kiss-and-run synaptic vesicle recycling
has_narrow_synonym: kiss-and-stay synaptic vesicle recycling
has_obo_namespace: biological_process
id: GO:0036465

neurotrophin signaling pathway
type: Class
subclass of: pathway
definition: A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
imported from: go.owl
created by: bf
creation date: 2013-03-27T17:22:44Z
has exact synonym: neurotrophin receptor signaling pathway
has_obo_namespace: biological_process
id: GO:0038179
comment: There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.

endothelial cell activation
type: Class
subclass of: cellular process
definition: The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
imported from: go.owl
has_obo_namespace: biological_process
id: GO:0042118

myelination
type: Class
subclass of: cellular process
definition: The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
imported from: go.owl
database cross reference: Wikipedia:Myelin
has_obo_namespace: biological_process
has_related_synonym: myelinogenesis
id: GO:0042552

cell projection
type: Class
subclass of: cellular anatomical entity
definition: A prolongation or process extending from a cell, e.g. a flagellum or axon.
imported from: go.owl
has_broad_synonym: cell process
has_broad_synonym: cellular process
has exact synonym: cellular projection
has_obo_namespace: cellular_component
id: GO:0042995
in subset: goslim agr
in subset: goslim flybase ribbon
in subset: goslim mouse
in subset: goslim pir

neuron projection
type: Class
subclass of: cell projection
definition: A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
imported from: go.owl
database cross reference: NIF_Subcellular:sao867568886
has exact synonym: neuron process
has exact synonym: neuron protrusion
has exact synonym: neuronal cell projection
has_narrow_synonym: neurite
has_obo_namespace: cellular_component
has_related_synonym: nerve fiber
id: GO:0043005
in subset: goslim pir

dendritic spine
type: Class
subclass of: neuron spine
subclass of: postsynapse
definition: A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
imported from: go.owl
database cross reference: NIF_Subcellular:sao1799103720
database cross reference: Wikipedia:Dendritic_spine
has exact synonym: dendrite spine
has_narrow_synonym: branched dendritic spine
has_narrow_synonym: mushroom dendritic spine
has_narrow_synonym: sessile dendritic spine
has_narrow_synonym: stubby dendritic spine
has_narrow_synonym: thin dendritic spine
has_obo_namespace: cellular_component
id: GO:0043197
in subset: goslim synapse

myelin sheath
type: Class
subclass of: cellular anatomical entity
definition: An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
imported from: go.owl
database cross reference: FMA:62983
database cross reference: NIF_Subcellular:sao593830697
database cross reference: Wikipedia:Myelin
has_narrow_synonym: Schwann cell myelin sheath
has_narrow_synonym: astrocyte sheath
has_narrow_synonym: oligodendrocyte myelin sheath
has_obo_namespace: cellular_component
id: GO:0043209

organelle
type: Class
subclass of: cellular anatomical entity
definition: Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
imported from: go.owl
database cross reference: NIF_Subcellular:sao1539965131
database cross reference: Wikipedia:Organelle
has_obo_namespace: cellular_component
id: GO:0043226
in subset: goslim chembl
in subset: goslim generic
in subset: goslim pir

post-translational protein modification
type: Class
subclass of: cellular process
definition: The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
imported from: go.owl
database cross reference: Wikipedia:Posttranslational_modification
has exact synonym: PTM
has exact synonym: post-translational amino acid modification
has exact synonym: post-translational modification
has exact synonym: posttranslational amino acid modification
has exact synonym: posttranslational modification
has exact synonym: posttranslational protein modification
has_obo_namespace: biological_process
id: GO:0043687
comment: This term should only be used to annotate a protein modification process that occurs after the protein has been released from the ribosome, and is therefore strictly post-translational. Modification of a free protein (one not attached to a ribosome) and modification of a C-terminal residue are post-translational processes. Some protein modifications occur while the protein is still in the ribosome but before translation has been completed; these modification processes are considered co-translational and should not be annotated using this term.

cellular metabolic process
type: Class
subclass of: metabolic process
subclass of: cellular process
definition: The chemical reactions and pathways by which individual cells transform chemical substances.
imported from: go.owl
has exact synonym: cellular metabolism
has_obo_namespace: biological_process
has_related_synonym: intermediary metabolism
id: GO:0044237

axonal growth cone
type: Class
subclass of: growth cone
definition: The migrating motile tip of a growing nerve cell axon.
imported from: go.owl
created by: jl
creation date: 2010-02-04T03:57:16Z
database cross reference: NIF_Subcellular:sao1594955670
database cross reference: NIF_Subcellular:sao203987954
has exact synonym: axon growth cone
has_obo_namespace: cellular_component
id: GO:0044295

neuron spine
type: Class
subclass of: neuron projection
definition: A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
imported from: go.owl
created by: jl
creation date: 2010-02-05T04:25:10Z
has_broad_synonym: spine
database cross reference: NIF_Subcellular:sao1145756102
has_obo_namespace: cellular_component
id: GO:0044309

biological process involved in interspecies interaction between organisms
type: Class
subclass of: biological_process
definition: Any process evolved to enable an interaction with an organism of a different species.
term tracker item: https://github.com/geneontology/go-ontology/issues/20191
imported from: go.owl
never in taxon: NCBITaxon 4895
has exact synonym: interaction with another species
has exact synonym: interspecies interaction
has exact synonym: interspecies interaction between organisms
has exact synonym: interspecies interaction with other organisms
has_obo_namespace: biological_process
id: GO:0044419
in subset: gocheck do not annotate
in subset: goslim candida
in subset: goslim pir

biological phase
type: Class
subclass of: biological_process
definition: A distinct period or stage in a biological process or cycle.
imported from: go.owl
created by: jl
creation date: 2014-07-16T13:12:40Z
has_obo_namespace: biological_process
id: GO:0044848
in subset: gocheck do not manually annotate
comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase.

membrane raft
type: Class
subclass of: membrane microdomain
definition: Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
imported from: go.owl
database cross reference: Wikipedia:Lipid_raft
has exact synonym: lipid raft
has_obo_namespace: cellular_component
has_related_synonym: GEM domain
has_related_synonym: glycolipid-enriched membrane domain
id: GO:0045121

synapse
type: Class
subclass of: cell junction
definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
imported from: go.owl
database cross reference: NIF_Subcellular:sao914572699
database cross reference: Wikipedia:Chemical_synapse
has exact synonym: synaptic junction
has_narrow_synonym: mixed synapse
has_obo_namespace: cellular_component
has_related_synonym: electrotonic synapse
id: GO:0045202
in subset: goslim agr
in subset: goslim drosophila
in subset: goslim flybase ribbon
in subset: goslim mouse
in subset: goslim pir
in subset: goslim synapse

pore complex
type: Class
subclass of: membrane protein complex
definition: A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids.
term tracker item: https://github.com/geneontology/go-ontology/issues/20452
imported from: go.owl
has exact synonym: pore
has_obo_namespace: cellular_component
has_related_synonym: channel-forming toxin activity
has_related_synonym: pore-forming toxin activity
id: GO:0046930

astrocyte activation
type: Class
subclass of: cellular process
definition: A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
imported from: go.owl
has_obo_namespace: biological_process
id: GO:0048143

response to stimulus
type: Class
subclass of: biological_process
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
imported from: go.owl
has_alternative_id: GO:0051869
has exact synonym: physiological response to stimulus
has_obo_namespace: biological_process
id: GO:0050896
in subset: gocheck do not manually annotate
in subset: goslim agr
in subset: goslim flybase ribbon
in subset: goslim mouse
in subset: goslim pir
comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC.

nuclear transport
type: Class
subclass of: cellular process
definition: The directed movement of substances into, out of, or within the nucleus.
imported from: go.owl
database cross reference: Wikipedia:Nuclear_transport
has exact synonym: nucleus transport
has_obo_namespace: biological_process
id: GO:0051169
in subset: goslim yeast

localization
type: Class
subclass of: biological_process
definition: Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.
imported from: go.owl
created by: jl
creation date: 2013-12-18T13:51:04Z
has_alternative_id: GO:1902578
has exact synonym: establishment and maintenance of localization
has exact synonym: establishment and maintenance of position
has exact synonym: localisation
has_narrow_synonym: establishment and maintenance of cellular component location
has_narrow_synonym: establishment and maintenance of substance location
has_narrow_synonym: establishment and maintenance of substrate location
has_obo_namespace: biological_process
has_related_synonym: single organism localization
has_related_synonym: single-organism localization
id: GO:0051179
in subset: goslim pir

defense response to virus
type: Class
subclass of: response to other organism
definition: Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
imported from: go.owl
has exact synonym: antiviral response
has exact synonym: defence response to virus
has exact synonym: defense response to viruses
has_obo_namespace: biological_process
id: GO:0051607

response to other organism
type: Class
subclass of: biological process involved in interspecies interaction between organisms
subclass of: response to stimulus
definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.
imported from: go.owl
has_alternative_id: GO:0009613
has_alternative_id: GO:0042828
has_obo_namespace: biological_process
id: GO:0051707

sulfation
type: Class
subclass of: cellular metabolic process
definition: The addition of a sulfate group to a molecule.
imported from: go.owl
has_broad_synonym: phase II metabolism
has exact synonym: sulfonation
has exact synonym: sulfur addition
has exact synonym: sulphation
has exact synonym: sulphur addition
has_obo_namespace: biological_process
id: GO:0051923

transmembrane transport
type: Class
subclass of: localization
definition: The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
imported from: go.owl
created by: tb
creation date: 2015-10-21T13:22:47Z
has_alternative_id: GO:0090662
has exact synonym: membrane transport
has_narrow_synonym: ATP hydrolysis coupled transmembrane transport
has_obo_namespace: biological_process
id: GO:0055085
in subset: goslim chembl
in subset: goslim generic
in subset: goslim pombe
in subset: goslim yeast
comment: Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes.

inflammasome complex
type: Class
subclass of: protein-containing complex
definition: A cytosolic protein complex that is capable of activating caspase-1.
imported from: go.owl
created by: dph
creation date: 2015-05-08T14:30:54Z
has_obo_namespace: cellular_component
id: GO:0061702

biological regulation
type: Class
subclass of: biological_process
definition: Any process that modulates a measurable attribute of any biological process, quality or function.
imported from: go.owl
has_broad_synonym: regulation
has_obo_namespace: biological_process
id: GO:0065007
in subset: gocheck do not annotate
in subset: goslim pir

glycosylation
type: Class
subclass of: metabolic process
subclass of: molecular process
definition: The covalent attachment and further modification of carbohydrate residues to a substrate molecule.
imported from: go.owl
database cross reference: Wikipedia:Glycosylation
has_obo_namespace: biological_process
id: GO:0070085

exocytic vesicle
type: Class
subclass of: organelle
definition: A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
imported from: go.owl
has exact synonym: exocytic constitutive secretory pathway transport vesicle
has exact synonym: exocytotic vesicle
has_obo_namespace: cellular_component
id: GO:0070382

phosphatidylserine exposure on apoptotic cell surface
type: Class
subclass of: cellular process
definition: A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity.
imported from: go.owl
created by: mah
creation date: 2009-07-02T02:41:44Z
has exact synonym: externalization of phosphatidylserine
has_obo_namespace: biological_process
id: GO:0070782
comment: In normal cells, phosphatidylserine residues are found exclusively on the inner side of the cellular membrane. During apoptosis, phosphatidylserine is transported to the outer cell surface by scramblase proteins. This event acts as an "eat-me" signal for macrophages to dispose of the dying cell. When annotating to this term, curators should be aware of the following: 1) phosphatidylserine exposure on the cell surface can occur in circumstances other than apoptosis (for example, when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system, see PMID:21107324). Do not annotate to GO:0070782 unless phosphatidylserine exposure is shown to be part of an apoptotic event. 2) Caution should be applied when a study quotes annexin V assays. The annexin A5 protein binds to phosphatidylserine-containing membrane surfaces, which are usually only present on the inner leaflet of the membrane. However, in cells undergoing apoptosis, phosphatidylserine becomes exposed on the outer leaflet of the membrane. A positive annexin assay can therefore be linked to apoptotic death, but it shouldn't be confused with molecular events strictly involved in the process of phosphatidylserine exposure.

demethylation
type: Class
subclass of: metabolic process
definition: The process of removing one or more methyl groups from a molecule.
imported from: go.owl
created by: mah
creation date: 2009-10-29T03:12:51Z
has_obo_namespace: biological_process
id: GO:0070988

neuron death
type: Class
subclass of: cell death
definition: The process of cell death in a neuron.
imported from: go.owl
created by: mah
creation date: 2009-11-03T02:37:17Z
has exact synonym: neuron cell death
has exact synonym: neuronal cell death
has_obo_namespace: biological_process
id: GO:0070997
comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate.

potassium ion transmembrane transport
type: Class
subclass of: ion transport
definition: A process in which a potassium ion is transported from one side of a membrane to the other.
imported from: go.owl
created by: mah
creation date: 2010-09-03T02:43:49Z
has_alternative_id: GO:0010163
has exact synonym: potassium ion membrane transport
has_narrow_synonym: high affinity potassium ion import
has_narrow_synonym: high affinity potassium ion uptake
has_narrow_synonym: high-affinity potassium ion import
has_narrow_synonym: high-affinity potassium ion uptake
has_obo_namespace: biological_process
id: GO:0071805
comment: Note that this term is not intended for use in annotating lateral movement within membranes.

amyloid-beta clearance
type: Class
subclass of: biological_process
definition: The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
imported from: go.owl
created by: pr
creation date: 2012-02-16T05:32:29Z
has exact synonym: beta-amyloid clearance
has_obo_namespace: biological_process
id: GO:0097242

prenylation
type: Class
subclass of: cellular metabolic process
definition: The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups may be added.
imported from: go.owl
created by: pr
creation date: 2012-07-03T01:12:19Z
has_obo_namespace: biological_process
id: GO:0097354

Lewy body
type: Class
subclass of: inclusion body
definition: Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein.
imported from: go.owl
created by: pr
creation date: 2012-11-06T16:26:08Z
database cross reference: NIF_Subcellular:sao4933778419
has_obo_namespace: cellular_component
has_related_synonym: cytoplasmic inclusion
id: GO:0097413

bounding membrane of organelle
type: Class
subclass of: organelle membrane
definition: The lipid bilayer that forms the outer-most layer of an organelle.
imported from: go.owl
created by: dos
creation date: 2014-02-26T13:41:31Z
has_obo_namespace: cellular_component
id: GO:0098588
comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes.

postsynapse
type: Class
subclass of: cellular anatomical entity
definition: The part of a synapse that is part of the post-synaptic cell.
imported from: go.owl
has_obo_namespace: cellular_component
id: GO:0098794
in subset: goslim synapse

membrane protein complex
type: Class
subclass of: protein-containing complex
definition: Any protein complex that is part of a membrane.
imported from: go.owl
has_obo_namespace: cellular_component
id: GO:0098796
in subset: goslim metagenomics

plasma membrane protein complex
type: Class
subclass of: membrane protein complex
definition: Any protein complex that is part of the plasma membrane.
imported from: go.owl
has_obo_namespace: cellular_component
id: GO:0098797

membrane microdomain
type: Class
subclass of: membrane
definition: A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it.
imported from: go.owl
has_obo_namespace: cellular_component
id: GO:0098857

axonal transport
type: Class
subclass of: cellular process
definition: The directed movement of organelles or molecules along microtubules in axons.
imported from: go.owl
database cross reference: Wikipedia:Axoplasmic_transport
has exact synonym: axon cargo transport
has exact synonym: axoplasmic transport
has_obo_namespace: biological_process
id: GO:0098930
in subset: goslim synapse

supramolecular complex
type: Class
subclass of: cellular anatomical entity
definition: A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber.
imported from: go.owl
has_obo_namespace: cellular_component
id: GO:0099080

postsynaptic specialization
type: Class
subclass of: organelle
definition: A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
imported from: go.owl
has_obo_namespace: cellular_component
id: GO:0099572
in subset: goslim synapse

cellular anatomical entity
type: Class
subclass of: cellular_component
definition: A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.
imported from: go.owl
created by: kmv
creation date: 2019-08-12T18:01:37Z
has_obo_namespace: cellular_component
id: GO:0110165

catalytic complex
type: Class
subclass of: enzyme
definition: A protein complex which is capable of catalytic activity.
imported from: go.owl
created by: bhm
creation date: 2013-11-13T16:18:47Z
has exact synonym: enzyme complex
has_obo_namespace: cellular_component
id: GO:1902494
in subset: goslim metagenomics

neurofibrillary tangle assembly
type: Class
subclass of: cellular process
definition: The aggregation, arrangement and bonding together of a set of components to form a neurofibrillary tangle.
imported from: go.owl
created by: sjp
creation date: 2014-05-08T09:19:51Z
has exact synonym: neurofibrillary tangle formation
has_narrow_synonym: flame-shaped neurofibrillary tangle assembly
has_narrow_synonym: flame-shaped neurofibrillary tangle formation
has_narrow_synonym: star-shaped neurofibrillary tangle assembly
has_narrow_synonym: star-shaped neurofibrillary tangle formation
has_obo_namespace: biological_process
id: GO:1902988
comment: Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).

glucose transmembrane transport
type: Class
subclass of: transmembrane transport
definition: The process in which glucose is transported across a membrane.
imported from: go.owl
created by: vw
creation date: 2015-09-04T17:20:16Z
has_alternative_id: GO:0015758
has_obo_namespace: biological_process
has_related_synonym: glucose transport
id: GO:1904659

lipoprotein particle
type: Class
subclass of: protein-containing complex
definition: A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph.
imported from: go.owl
created by: pr
creation date: 2015-06-18T08:42:53Z
has_obo_namespace: cellular_component
id: GO:1990777

Wnt-Frizzled-LRP5/6 complex
type: Class
subclass of: plasma membrane protein complex
definition: A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6.
imported from: go.owl
created by: bf
creation date: 2015-09-14T15:59:54Z
has_broad_synonym: Wnt receptor complex
has exact synonym: Wnt-FZD-LRP5/6 trimeric complex
has exact synonym: Wnt.Fz.LRP ternary complex
has_narrow_synonym: Fz/Wnt/LRP6 complex
has_narrow_synonym: WNT-FZD-LRP5 complex
has_narrow_synonym: WNT-FZD-LRP6 complex
has_obo_namespace: cellular_component
has_related_synonym: Frizzled-LRP5/6 complex
has_related_synonym: Wnt-induced Frizzled-LRP5/6 complex
id: GO:1990851
comment: Given the number of Wnt proteins, Frizzled proteins and LRP proteins, many different trimeric complexes are likely to form.

behavioral therapy
type: Class
subclass of: therapeutic procedure
definition: A broad term referring to clinical psychotherapy that uses techniques derived from behaviorism.
definition: Therapeutic approach that may employ classical conditioning, operant learning techniques, or other behavioral techniques, in an attempt to eliminate or modify problem behavior, addressing itself primarily to the client's overt behavior, as opposed to thoughts, feelings, or other cognitive processes.
imported from: gsso.owl
is referenced by: https://books.google.com/books/
has_broad_synonym: behavioral intervention
database cross reference: https://en.wikipedia.org/wiki/Behaviour_therapy
database cross reference: https://en.wikipedia.org/wiki/Category:Behavior_therapy
database cross reference: https://www.wikidata.org/wiki/Q1483649
has synonym: behavior therapy
has synonym: behavioral psychotherapy
alternate name: behavioral therapies
Library of Congress Subject Headings: http://id.loc.gov/authorities/subjects/sh85012900
Library of Congress Classification: RC489.B4
see also: GSSO_003378
ICD-9-CM: 94.33
Medical Dictionary for Regulatory Activities ID: http://purl.bioontology.org/ontology/MEDDRA/10074786
MeSH Descriptor ID: http://purl.bioontology.org/ontology/MESH/D001521
SNOMED CT Identifier: http://purl.bioontology.org/ontology/SNOMEDCT/166001

case report
type: Class
subclass of: information content entity
definition: A case report is a detailed report of the symptoms, signs, diagnosis, treatment, and follow-up of an individual patient.
imported from: gsso.owl
database cross reference: https://en.wikipedia.org/wiki/Case_report
alternate name: case reports

model
type: Class
subclass of: independent continuant
definition: A person who serves as a subject for artwork or fashion, usually in the medium of photography but also for painting or drawing.
imported from: gsso.owl
database cross reference: https://en.wikipedia.org/wiki/Category:Models_(profession)
has_narrow_synonym: fashion model
alternate name: models
different from: SIO_000510

crude death rate
type: Class
subclass of: rate
definition: Mortality from all causes in a given time interval, for a given population.
imported from: gsso.owl

Phenotypic abnormality
type: Class
subclass of: quality
definition: A phenotypic abnormality.
imported from: hp.owl
database cross reference: UMLS:C4021819
has exact synonym: Organ abnormality
has_obo_namespace: human_phenotype
id: HP:0000118
comment: This is the root of the phenotypic abnormality subontology of the HPO.

Abnormality of the nervous system
type: Class
subclass of: Phenotypic abnormality
definition: An abnormality of the nervous system.
imported from: hp.owl
has_alternative_id: HP:0001333
has_alternative_id: HP:0006987
has_broad_synonym: Brain and/or spinal cord issue
database cross reference: MSH:D009421
database cross reference: SNOMEDCT_US:88425004
database cross reference: UMLS:C0497552
has exact synonym: Abnormality of the nervous system
has exact synonym: Neurologic abnormalities
has exact synonym: Neurological abnormality
id: HP:0000707
comment: The nervous system comprises the neuraxis (brain, spinal cord, and ventricles), the autonomic nervous system, the enteric nervous system, and the peripheral nervous system.

Apathy
type: Class
subclass of: Abnormal nervous system physiology
imported from: hp.owl
database cross reference: MSH:D057565
database cross reference: SNOMEDCT_US:20602000
database cross reference: UMLS:C0085632
has exact synonym: Lack of feeling, emotion, interest
has_obo_namespace: human_phenotype
id: HP:0000741

Personality changes
type: Class
subclass of: Abnormal nervous system physiology
definition: An abnormal shift in patterns of thinking, acting, or feeling.
imported from: hp.owl
database cross reference: SNOMEDCT_US:102943000
database cross reference: SNOMEDCT_US:192073007
database cross reference: UMLS:C0240735
has exact synonym: Personality change
has exact synonym: Personality changes
has_obo_namespace: human_phenotype
id: HP:0000751
comment: This term refers to changes in personality that are perceived as being abnormal. It does not refer to the usual gradual personality changes that tend to accompany aging and certain life situations.

Vomiting
type: Class
subclass of: digestive system symptom
definition: Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.
imported from: hp.owl
database cross reference: MEDDRA:10047700
database cross reference: MSH:D014839
database cross reference: SNOMEDCT_US:249497008
database cross reference: SNOMEDCT_US:300359004
database cross reference: SNOMEDCT_US:422400008
database cross reference: UMLS:C0042963
has exact synonym: Emesis
has exact synonym: Throwing up
has exact synonym: Vomiting
has_obo_namespace: human_phenotype
id: HP:0002013
in subset: hposlim core

Neurodegeneration
type: Class
subclass of: Abnormal nervous system morphology
subclass of: Restriction
  on property: isClinicalMarkerFor
  some values from: Alzheimer's disease
definition: Progressive loss of neural cells and tissue.
imported from: hp.owl
database cross reference: MSH:D009410
database cross reference: MSH:D019636
database cross reference: UMLS:C0027746
database cross reference: UMLS:C0524851
database cross reference: UMLS:C4020854
has exact synonym: Ongoing loss of nerve cells
has_related_synonym: Neuro-degenerative disease
has_related_synonym: Neurodegenerative disease
has_related_synonym: Progressive neurodegenerative disorder
id: HP:0002180

Neurofibrillary tangles
type: Class
subclass of: Abnormal nervous system morphology
subclass of: Restriction
  on property: isClinicalMarkerFor
  some values from: Alzheimer's disease
definition: Pathological protein aggregates formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form.
imported from: hp.owl
has_alternative_id: HP:0003132
has_alternative_id: HP:0007070
database cross reference: MSH:D016874
database cross reference: SNOMEDCT_US:85775002
database cross reference: UMLS:C0085400
has exact synonym: Neurofibrillary tangles composed of disordered microtubules in neurons
has exact synonym: Paired helical filaments
has_obo_namespace: human_phenotype
id: HP:0002185

Apraxia
type: Class
subclass of: Abnormal nervous system physiology
definition: A defect in the understanding of complex motor commands and in the execution of certain learned movements, i.e., deficits in the cognitive components of learned movements.
imported from: hp.owl
database cross reference: MSH:D001072
database cross reference: SNOMEDCT_US:68345001
database cross reference: SNOMEDCT_US:6950007
database cross reference: UMLS:C0003635
has_obo_namespace: human_phenotype
has_related_synonym: Apraxias
id: HP:0002186

Aphasia
type: Class
subclass of: Abnormal nervous system physiology
definition: An acquired language impairment of some or all of the abilities to produce or comprehend speech and to read or write.
imported from: hp.owl
database cross reference: MSH:D001037
database cross reference: SNOMEDCT_US:87486003
database cross reference: UMLS:C0003537
has exact synonym: Difficulty finding words
has exact synonym: Losing words
has exact synonym: Loss of words
id: HP:0002381
comment: Aphasia is caused by brain injury. The most common cause is stroke, but aphasia can also be caused by other factors such as head trauma, brain tumors, or infections.

Amyotrophic lateral sclerosis
type: Class
subclass of: Abnormal nervous system morphology
imported from: hp.owl
database cross reference: MSH:D000690
database cross reference: SNOMEDCT_US:86044005
database cross reference: UMLS:C0002736
has_obo_namespace: human_phenotype
has_related_synonym: Lou Gehrig's disease
id: HP:0007354

Abnormality of immune system physiology
type: Class
subclass of: Phenotypic abnormality
definition: A functional abnormality of the immune system.
imported from: hp.owl
created by: peter
creation date: 2011-02-07T04:28:55Z
database cross reference: UMLS:C4023616
id: HP:0010978

Allergy
type: Class
subclass of: Abnormality of immune system physiology
definition: An allergy is an immune response or reaction to substances that are usually not harmful.
imported from: hp.owl
created by: peter
creation date: 2013-11-07T07:47:22Z
database cross reference: MSH:D006967
database cross reference: SNOMEDCT_US:419076005
database cross reference: UMLS:C1527304
has exact synonym: Allergy
id: HP:0012393

Abnormal nervous system physiology
type: Class
subclass of: Abnormality of the nervous system
definition: A functional anomaly of the nervous system.
imported from: hp.owl
created by: peter
creation date: 2014-01-19T08:02:46Z
database cross reference: UMLS:C4022811
has exact synonym: Abnormality of nervous system physiology
has_obo_namespace: human_phenotype
id: HP:0012638

Abnormal nervous system morphology
type: Class
subclass of: Abnormality of the nervous system
definition: A structural anomaly of the nervous system.
imported from: hp.owl
created by: peter
creation date: 2014-01-19T08:03:08Z
database cross reference: Fyler:4135
database cross reference: Fyler:4300
database cross reference: UMLS:C4022810
has exact synonym: Abnormal nervous system morphology
has exact synonym: Abnormal shape of nervous system
has exact synonym: Abnormality of nervous system morphology
has_obo_namespace: human_phenotype
id: HP:0012639

Parageusia
type: Class
subclass of: Phenotypic abnormality
definition: A distortion of the sense of taste, often characterized by the sensation of a metallic taste.
imported from: hp.owl
date: 2017-08-12T13:35:52Z
created by: peter
has exact synonym: Altered sense of taste
has exact synonym: Dysgeusia
has exact synonym: Metallic taste
has exact synonym: Metallic taste in mouth

Family history
type: Class
subclass of: clinical history
subclass of: Restriction
  on property: isRiskFactorFor
  some values from: Alzheimer's disease
definition: Information about close relatives of an individual who is the proband of a study or who is being investigated with the goal of identifying a medical diagnosis. Usually, the family history includes information from three generations of relatives, including children, brothers and sisters, parents, aunts and uncles, nieces and nephews, grandparents, and cousins.
imported from: hp.owl
date: 2019-02-14T11:40:50Z
created by: peter
comment: This subontology is intended to help record summary information about family members if only a limited amount of information is available or required.

Past medical history
type: Class
subclass of: Personal Attribute
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: In a medical encounter, the physician generally will interview the patient about his or her current problem, and may perform additional testing. The past medical history (PMH) in contrast records information about the patient's medical, personal and family history that might be relevant to the presenting illness or to provide optimal clinical management. The PMH generally includes (if relevant) other major illnesses, hospitalizations, surgeries, injuries, allergies, gynecologic and obstetric history, family history, personal history including occupational history, alcohol and drug use, etc.
imported from: hp.owl
date: 2019-03-03T16:39:26Z
created by: peter
comment: This subontology of the HPO is not intended to provide all needed terms to describe the past medical history, but rather to be combined with other ontologies such as MONDO in order to capture information that is often needed to properly assess phenotypic findings related to a presenting medical problem.

Neuroinflammation
type: Class
subclass of: Abnormality of immune system physiology
definition: Activation of the brain's innate immune system in response to an inflammatory challenge and is characterized by a host of cellular and molecular changes within the brain.
imported from: hp.owl
date: 2021-01-09T17:51:49Z
created by: peter

data item
type: Class
subclass of: information content entity
editor preferred label: data item
example of usage: Data items include counts of things, analyte concentrations, and statistical summaries.
has curation status: IAO_0000125
definition: a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements.
editor note: 2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers.
editor note: 2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum.
editor note: 2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym.
editor note: 2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/
editor note: JAR: datum -- well, this will be very tricky to define, but maybe some information-like stuff that might be put into a computer and that is meant, by someone, to denote and/or to be interpreted by some process... I would include lists, tables, sentences... I think I might defer to Barry, or to Brian Cantwell Smith JAR: A data item is an approximately justified approximately true approximate belief
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Chris Stoeckert
definition editor: PERSON: Jonathan Rees
alternative term: data
imported from: iao.owl
imported from: mfomd.owl

information content entity
type: Class
subclass of: generically dependent continuant
editor preferred label: information content entity
example of usage: Examples of information content entites include journal articles, data, graphical layouts, and graphs.
has curation status: IAO_0000122
definition: A generically dependent continuant that is about some thing.
definition: An information content entity is an entity that is generically dependent on some artifact and stands in relation of aboutness to some entity
editor note: 2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ).
editor note: information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907). Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity.
definition editor: PERSON: Chris Stoeckert
definition source: OBI_0000142
imported from: iao.owl
imported from: mfomd.owl

measurement datum
type: Class
subclass of: data item
editor preferred label: measurement datum
example of usage: Examples of measurement data are the recoding of the weight of a mouse as {40,mass,"grams"}, the recording of an observation of the behavior of the mouse {,process,"agitated"}, the recording of the expression level of a gene as measured through the process of microarray experiment {3.4,luminosity,}.
has curation status: IAO_0000125
definition: A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device.
editor note: 2/2/2009 is_specified_output of some assay?
definition editor: person:Chris Stoeckert
definition source: OBI_0000305
definition source: group:OBI
imported from: iao.owl

pregnant woman
type: Class
subclass of: human being
definition: A woman who is pregnant.
curator note: Could reuse: http://purl.obolibrary.org/obo/ontoneo/ONTONEO_00000197
imported from: ico.owl

receptor
type: Class
subclass of: role
type: NamedIndividual
id: IDOMAL:0000373
definition: A molecule on the surface or within a cell that recognizes and binds with specific molecules, producing a specific effect in the cell.
creation date: 2009-11-22T06:45:49Z
notation: IDOMAL:0000373
created by: guest
tree view: snap Role
has_obo_namespace: idomal_namespace
imported from: idomal.owl

C3b
type: Class
subclass of: Complement Component Protein
type: NamedIndividual
definition: C3b is the principal protein fragment produced when complement component C3 is cleaved by convertases of either the classical or alternative pathway. C3b aids in opsonization.
has_obo_namespace: idomal_namespace
created by: guest
notation: IDOMAL:0000581
has exact synonym: complement component 3b
imported from: idomal.owl
tree view: IDOMAL_0001233
id: IDOMAL:0000581
creation date: 2009-11-23T02:17:58Z

activation-induced cell death
type: Class
subclass of: cell death
tree view: cell death
definition: It is the process by which cells undergo apoptosis in a controlled manner through the interaction of a death factor and its receptor. It plays a significant role in immune system homeostasis.
imported from: idomal.owl
created by: guest
creation date: 2009-12-08T09:48:03Z
has exact synonym: AICD
has_obo_namespace: idomal_namespace
id: IDOMAL:0000816
notation: IDOMAL:0000816

monkey
type: Class
subclass of: Animal Model
tree view: IDOMAL_0000606
definition: Any primate that is not a prosimian (lemurs and tarsiers) or an ape.
imported from: idomal.owl
created by: louis
creation date: 2009-06-03T02:20:26Z
has_obo_namespace: idomal_namespace
id: IDOMAL:0001219
notation: IDOMAL:0001219

up-regulation
type: Class
subclass of: regulation
definition: a positive regulation that one interactor up-regulates another.
definition editor: YH
imported from: ino.owl
has literature mining keywords: up-regulate, up-regulations, up-regulated, up-regulating, upregulate, upregulations, upregulated, upregulating

cell-cell interaction
type: Class
subclass of: process
definition: a biological interaction that involves two cells as interactors.
imported from: ino.owl
creator: YL.YH. ZX.

regulation of transcription
type: Class
subclass of: regulation
definition: a gene expression regulation process that involves the regulation of a gene transcription.
definition editor: YH, AO, JH
alternative term: regulation of gene transcription
imported from: ino.owl
has literature mining keywords: transcribed, transcribed by, regulates the transcription of, regulated the transcription of, regulates // transcription, regulated // transcription, under the control of // transcription, essential for // transcription, trascription depends, transcription // dependent, control // transcription, controlling // transcription, requires // transcription
has keyword dependency pattern: amod(transcription, controlling), amod(transcription, dependent), amod(expression, dependent), nsubj(dependent, transcription), nsubj(control, expression), nmod:for(regulator, transcription), nmod:of(activator, transcription), nsubjpass(recognized, promoter)

down-regulation
type: Class
subclass of: regulation
definition: a negative regulation that one interactor down-regulates another.
definition editor: YH, ZX
imported from: ino.owl
has literature mining keywords: down-regulate, down-regulated, down-regulates, down-regulating, down-regulation, downregulate, downregulated, downregulates, downregulating, downregulation, downmodulation, depress, depressed, depresses, depressing, suppress, suppressed, suppresses, suppressing, suppression, suppressor, repress, repressed, represses, repressing, repression, repressor, repressors

oxidation
type: Class
subclass of: enzymatic reaction
editor note: an enzymatic reaction where a molecule gains oxygen.
definition editor: YH, ZX
imported from: ino.owl
has literature mining keywords: oxidate, oxidated, oxidates, oxidating, oxidation, oxidise, oxidised, oxidises, oxidising, oxidize, oxidized, oxidizes, oxidizing

regulation
type: Class
subclass of: process
definition: A regulation represents a regulatory interaction between two interactors.
definition editor: YH, ZX, AO, JH
imported from: ino.owl
has literature mining keywords: regulate, regulated, regulates, regulating, regulation, regulator, modulate, modulated, modulates, modulating, modulation, mediate, mediated, mediates, mediating, influence, influenced, influences, influencing, affect, affected, affecting, affects, impact, impacted, impacting, impacts, effect, effected, effecting, effects, require, required, requires, requiring, respond, responded, responding, responds, responsive, change, changed, changes, changing, alter, altered, altering, alters, modified, modifies, modify, modifying, depend, depended, depending, depends, direct, directed, directing, directs, drive, driven, drives, driving, cause, caused, causes, causing, lead, leading, leads, led, target, targeted, targeting, targets, dependent, essential for

translocation
type: Class
subclass of: process
definition: A process that changes the location of a material entity.
definition editor: YH, ZX
imported from: ino.owl
has literature mining keywords: translocation, transloated, translocating, translocates, migrated, migration, migrates migrating, mobilization, mobilize, mobilized, mobilizes, mobilizing, mobilisation, mobilise, mobilised, mobilises, mobilising

diagnostic procedure
type: Class
subclass of: medical intervention
definition: Any procedure or test to diagnose a disease or disorder.
imported from: maxo.owl
date: 2018-11-16T20:10:20Z
created by: http://orcid.org/0000-0001-7941-2961
database cross reference: NCIT:C18020
database cross reference: OGMS:0000104
has exact synonym: diagnostic technique procedure
has exact synonym: diagnostic testing

pharmacotherapy
type: Class
subclass of: therapeutic procedure
definition: Use of a substance introduced into a living organism with therapeutic or diagnostic purpose.
imported from: maxo.owl
date: 2019-01-15T18:20:06Z
created by: http://orcid.org/0000-0001-7941-2961
database cross reference: CHEBI:52217
has exact synonym: drug therapy
has exact synonym: drug treatment
has exact synonym: medication therapy
has exact synonym: pharmaceutical drug
has exact synonym: pharmaceutical treatment
has exact synonym: pharmacological treatment
has exact synonym: treatment with drug
comment: Medical treatment by means of drugs.

antidementia agent therapy
type: Class
subclass of: pharmacotherapy
definition: Treatment with medications to improve cognition and function for patients with dementia.
imported from: maxo.owl
date: 2019-01-22T18:00:43Z
created by: http://orcid.org/0000-0001-7941-2961
has exact synonym: antidementia drug therapy
has exact synonym: antidementia medication treatment

cardiovascular agent therapy
type: Class
subclass of: pharmacotherapy
definition: Use of a drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
imported from: maxo.owl
date: 2019-01-22T18:13:06Z
created by: http://orcid.org/0000-0001-7941-2961
database cross reference: CHEBI:35554
database cross reference: NCIT:C78274
has exact synonym: agent affecting cardiovascular system therapy
has exact synonym: cardiovascular agent drug treatment
has exact synonym: cardiovascular drug therapy
has exact synonym: cardiovascular drug treatment therapy
has exact synonym: cardiovascular system agent therapy
has exact synonym: cardiovascular system drug therapy
has exact synonym: treatment with cardiovascular agent
has exact synonym: treatment with cardiovascular drug
has exact synonym: treatment with cardiovascular medication
has exact synonym: treatment with cardiovascular therapy
has_narrow_synonym: treatment with heart agent
has_narrow_synonym: treatment with heart drug
has_narrow_synonym: treatment with heart medication

cholinesterase inhibitor therapy
type: Class
subclass of: enzyme inhibitor agent therapy
definition: They are a group of drugs that block the normal breakdown of acetylcholine (ACh) into acetate and choline and thereby increase both the levels and duration of actions of acetylcholine found in the central and peripheral nervous system.
imported from: maxo.owl
date: 2019-01-22T18:32:56Z
created by: http://orcid.org/0000-0001-7941-2961
database cross reference: CHEBI:37733
has exact synonym: EC 3.1.1.8 (cholinesterase) inhibitor therapy
has exact synonym: cholinesterase inhibitor drug treatment
has exact synonym: cholinesterase inhibitor medication therapy
has exact synonym: treatment with EC 3.1.1.8 (cholinesterase) inhibitor
comment: Neurogenerative diseases such as Alzheimer disease, Parkinson disease, and Lewy body dementia are indications for cholinesterase inhibitor therapy.

clinical assessment
type: Class
subclass of: diagnostic procedure
definition: A measurement performed in a clinical setting using clinician's observations and instrument data to inform patient care and research.
imported from: maxo.owl
date: 2020-01-21T20:29:43Z
created by: http://orcid.org/0000-0001-7941-2961
database cross reference: CMO:0000000
database cross reference: PMID:2647562
has exact synonym: clinical measurement

molecular pathway modifying agent therapy
type: Class
subclass of: pharmacotherapy
imported from: maxo.owl
date: 2020-05-28T19:11:27Z
created by: http://orcid.org/0000-0001-7941-2961
has exact synonym: CHEBI:52206
has exact synonym: biochemical role therapy
has exact synonym: treatment with biochemical role

enzyme inhibitor agent therapy
type: Class
subclass of: pharmacotherapy
subclass of: molecular pathway modifying agent therapy
definition: A therapy using a compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
imported from: maxo.owl
date: 2020-06-02T18:44:24Z
created by: http://orcid.org/0000-0001-7941-2961
database cross reference: CHEBI:23924
has exact synonym: enzyme inhibitor drug treatment
has exact synonym: enzyme inhibitor medication treatment
has exact synonym: enzyme inhibitor therapy
has exact synonym: treatment with enzyme inhibitor
has exact synonym: treatment with enzyme inhibitor agent
has exact synonym: treatment with enzyme inhibitor drug
has exact synonym: treatment with enzyme inhibitor medication
has exact synonym: treatment with enzyme inhibitor therapy

ACE inhibitor therapy
type: Class
subclass of: cardiovascular agent therapy
definition: Use of a drug that inhibits angiotensin-converting enzyme (ACE), an enzyme that catalyzes the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in a reduction in angiotensin II and angiotensin II-induced aldosterone secretion, causing vasodilation and natriuresis.
imported from: maxo.owl
date: 2020-06-04T17:31:19Z
created by: http://orcid.org/0000-0001-7941-2961
database cross reference: CHEBI:147289
database cross reference: NCIT:C247
has exact synonym: Treatment with ACE inhibitor
has exact synonym: Treatment with angiotensin-converting enzyme inhibitor
has exact synonym: angiotensin-converting enzyme inhibitor therapy

ACE 1 inhibitor therapy
type: Class
subclass of: ACE inhibitor therapy
definition: Use of a drug that inhibits angiotensin-converting enzyme (ACE) 1, an enzyme that catalyzes the conversion of angiotensin I to angiotensin II.
imported from: maxo.owl
date: 2020-06-04T18:03:38Z
created by: http://orcid.org/0000-0001-7941-2961
database cross reference: CHEBI:35457
has exact synonym: EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor therapy
has exact synonym: Treatment with ACE-1 inhibitor
has exact synonym: Treatment with ACE1 inhibitor
has exact synonym: angiotensin-converting enzyme-1 inhibitor therapy
has exact synonym: peptidyl-dipeptidase A inhibitor therapy
has exact synonym: treatment with EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
has exact synonym: treatment with angiotensin I-converting enzyme inhibitor

ACE 2 inhibitor therapy
type: Class
subclass of: ACE inhibitor therapy
definition: Use of a drug that inhibits angiotensin-converting enzyme (ACE) 2, an enzyme that catalyzes the conversion of angiotensin I to angiotensin II.
imported from: maxo.owl
date: 2020-06-04T18:17:34Z
created by: http://orcid.org/0000-0001-7941-2961
has exact synonym: EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitor therapy
has exact synonym: Treatment with ACE-2 inhibitor
has exact synonym: angiotensin-converting enzyme-2 inhibitor therapy
has exact synonym: angiotensin-converting enzyme2 inhibitor therapy
has exact synonym: treatment with EC 3.4.17.23 (angiotensin-converting enzyme 2) inhibitor
has exact synonym: treatment with hACE2 inhibitor

HMG-CoA reductase inhibitor therapy
type: Class
subclass of: enzyme inhibitor agent therapy
definition: Therapy that inhibits HMG-CoA reductase inhibitor.
imported from: maxo.owl
date: 2020-11-17T21:37:04Z
created by: http://orcid.org/0000-0001-7941-2961
has exact synonym: EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor therapy
has exact synonym: hydroxymethylglutaryl-CoA reductase inhibitor therapy
has exact synonym: statin agent therapy
has exact synonym: treatment with EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor
has exact synonym: treatment with statins

pathological mental process
type: Class
subclass of: pathological bodily process
definition: A mental illness can be defined as a health condition that changes a person's thinking, feelings, or behavior (or all three) and that causes the person distress and difficulty in functioning.
definition source: http://www.jbiomedsem.com/content/1/1/10
imported from: mfomd.owl

Axiom
annotated source: pathological mental process
annotated property: definition
annotated target: A mental illness can be defined as a health condition that changes a person's thinking, feelings, or behavior (or all three) and that causes the person distress and difficulty in functioning.

cognitive process
type: Class
subclass of: mental process
definition: A mental process that creates, modifies or has as participant some cognitive representation.
imported from: mf.owl
imported from: mfomd.owl
see also: GO:0050890, cognition, defined as `The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.'

human being
type: Class
subclass of: material entity
definition: A member of the species Homo Sapiens.
alternative term: person
imported from: mf.owl

mental process
type: Class
subclass of: bodily process
definition: A mental process is a bodily process that is of a type such that it can of itself be conscious. Examples include thinking, feeling pain, remembering and emotion as occurrent experiences.
imported from: mf.owl
imported from: mfomd.owl
comment: A bodily process which brings into being, sustains or modifies a cognitive representation or a beahvior inducing state.
see also: GO:0050890, cognition, defined as `The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.'

mental disposition
type: Class
subclass of: disposition
definition: A mental disposition is a bodily disposition that is realized in a mental process.
imported from: mf.owl
imported from: mfomd.owl

hydroxylation reaction
type: Class
subclass of: enzymatic reaction
definition: Irreversible introduction of a hydroxyl group that can affect K,P,Y or R residues. Hydroxylation is the first step in the oxidative degeneration of organic compounds.
imported from: mi.owl
has exact synonym: hydroxylation
has_obo_namespace: PSI-MI
id: MI:0210
in subset: PSI-MI slim

palmitoylation reaction
type: Class
subclass of: enzymatic reaction
definition: Covalent attachment of palmitic acid to the cysteine residues of membrane proteins. Reversible reaction that can affect C,K,T or S residues.
imported from: mi.owl
has exact synonym: palmitoylation
has_obo_namespace: PSI-MI
id: MI:0216
in subset: PSI-MI slim

enzymatic reaction
type: Class
subclass of: cellular process
definition: terms aiming to represent biochemical reactions referring to their resulting product modifications.
imported from: mi.owl
has exact synonym: Biochemical reaction
has_obo_namespace: PSI-MI
id: MI:0414
in subset: PSI-MI slim

enzyme
type: Class
subclass of: biological role
definition: Molecule catalyzing a modification on its interacting partner.
imported from: mi.owl
has_obo_namespace: PSI-MI
id: MI:0501
in subset: PSI-MI slim

decarboxylation reaction
type: Class
subclass of: enzymatic reaction
definition: Decarboxylation is a chemical reaction that releases carbon dioxide (CO2). Usually, decarboxylation refers to a reaction of carboxylic acids, removing a carbon atom from a carbon chain. Enzymes that catalyze decarboxylations are called decarboxylases or, the more formal term, carboxy-lyases (EC number 4.1.1).
imported from: mi.owl
created by: orchard
creation date: 2012-01-03T03:31:42Z
has exact synonym: decarboxylation
has_obo_namespace: PSI-MI
id: MI:1140
in subset: PSI-MI slim

measurement method
type: Class
subclass of: technique
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: The manner, procedure or technique by which a morphological or physiological state or property in a single individual or sample or a group of individuals or samples is assessed and a quantitative or qualitative value assigned.
imported from: mmo.owl
has_obo_namespace: measurement_method_ontology
id: MMO:0000000

positron emission tomography (PET)
type: Class
subclass of: measurement method
definition: Detection of gamma rays emitted from tissues after administration of natural biochemical substance into which positron emitting isotopes have been incorporated. The paths of the gamma rays resulting from collision of positrons and electrons are interpreted by a computer to form a representation of local concentrations of the isotope-containing substance.
imported from: mmo.owl
created by: mshimoyama
creation date: 2010-08-05T02:27:10Z
has_obo_namespace: measurement_method_ontology
has_related_synonym: PET scan
id: MMO:0000129

mass spectrometry
type: Class
subclass of: measurement method
definition: A method for identifying molecules based on the detection of the mass-to-charge ratio of ions generated from the molecule by vaporisation and electron bombardment. Deflection of the ions through a magnetic field results in a characteristic pattern which is used to define the molecule of interest.
imported from: mmo.owl
created by: JSmith
creation date: 2014-06-05T14:49:06Z
database cross reference: OBI:0000470
has exact synonym: mass spec
has_obo_namespace: measurement_method_ontology
id: MMO:0000534

L-methionine sulfoxide
type: Class
subclass of: protein modification process
definition: A protein modification that oxygenates an L-methionine residue to one of the diastereomeric L-methionine sulfoxide residues.
imported from: mod.owl
database cross reference: DiffAvg:
database cross reference: DiffFormula:
database cross reference: DiffMono:
database cross reference: Formula:
database cross reference: MassAvg:
database cross reference: MassMono:
database cross reference: Origin:
database cross reference: Source:
database cross reference: TermSpec:
database cross reference: UniProt:
database cross reference: Unimod:
has exact synonym: (2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid
has exact synonym: L-methionine (R)-S-oxide
has exact synonym: L-methionine (R)-sulfoxide
has exact synonym: L-methionine S-oxide
has exact synonym: L-methionine sulfoxide
has exact synonym: MOD_RES Methionine sulfoxide
has exact synonym: MetO
has exact synonym: Methionyl Sulfoxide
has exact synonym: oxym
has_obo_namespace: PSI-MOD
has_related_synonym: Oxidation
id: MOD:00719
in subset: PSI-MOD-slim
comment: From DeltaMass: Average Mass: 147 Formula:C5H9O1N2S Monoisotopic Mass Change:147.035 Average Mass Change:147.195 (formula incorrect, N and O reversed) References:PE Sciex.

congenital abnormality
type: Class
subclass of: disease
definition: Any abnormality, anatomical or biochemical, evident at birth or during the neonatal period.
imported from: mondo.owl
database cross reference: DOID:0080015
database cross reference: EFO:0003915
database cross reference: ICD10:Q00.Q99
database cross reference: ICD9:759.89
database cross reference: ICD9:759.9
database cross reference: MESH:D000013
database cross reference: NCIT:C2849
database cross reference: SCTID:276654001
database cross reference: UMLS:CN232116
has exact synonym: SCONG
has exact synonym: birth defect
has exact synonym: congenital Abnormality
has exact synonym: congenital abnormality
has exact synonym: congenital anatomic Abnormality
has exact synonym: congenital anatomical Abnormality
has exact synonym: congenital anomalies of fetus
has exact synonym: congenital anomaly
has exact synonym: congenital anomaly or birth defect
has exact synonym: congenital defect
has exact synonym: congenital defect/deformity
has exact synonym: congenital deformity
has exact synonym: congenital malformation
has exact synonym: defect/deformity, Congenital
has exact synonym: defect/deformity, congenital
has exact synonym: deformity/defect, Congenital
has exact synonym: physical disorder
has_related_synonym: CM - congenital malformation
has_related_synonym: fetal developmental abnormality
has_related_synonym: fetal malformation
has_related_synonym: foetal malformation
id: MONDO:0000839

alcohol abuse
type: Class
subclass of: disease
definition: The use of alcoholic beverages to excess, either on individual occasions ("binge drinking") or as a regular practice.
imported from: mondo.owl
conforms to: realized in response to environmental exposure.yaml
database cross reference: COHD:433753
database cross reference: DOID:1574
database cross reference: ICD10:F10.1
database cross reference: ICD9:305.0
database cross reference: ICD9:305.00
database cross reference: MESH:D000437
database cross reference: SCTID:15167005
has exact synonym: alcohol abuse
has exact synonym: ethanol abuse
has_related_synonym: abuse, alcohol
has_related_synonym: addiction, alcohol
has_related_synonym: alcohol addiction
has_related_synonym: alcohol dependence
has_related_synonym: alcohol use disorder
has_related_synonym: alcoholic intoxication, chronic
has_related_synonym: alcoholism
has_related_synonym: chronic alcoholic intoxication
has_related_synonym: dependence, alcohol
has_related_synonym: intoxication, chronic alcoholic
id: MONDO:0002046

hepatitis
type: Class
subclass of: digestive system disease
subclass of: endocrine system disease
subclass of: disorder by anatomical region
definition: An active inflammatory process affecting the liver for more than six months. Causes include viral infections, autoimmune disorders, drugs, and metabolic disorders.
imported from: mondo.owl
excluded subClassOf: NCBITaxon_10239
conforms to: inflammatory disease by site.yaml
conforms to: specific infectious disease by location.yaml
conforms to: specific inflammatory disease by site.yaml
database cross reference: DOID:2237
database cross reference: EFO:0008496
database cross reference: ICD10:K73.9
database cross reference: ICD9:570
database cross reference: ICD9:571.4
database cross reference: ICD9:571.40
database cross reference: ICD9:571.41
database cross reference: MESH:D006505
database cross reference: NCIT:C3095
database cross reference: SCTID:197268000
has exact synonym: Hepatitis
has exact synonym: hepatitis
has exact synonym: inflammation of liver
has exact synonym: liver inflammation
has_narrow_synonym: acute and subacute liver necrosis
has_narrow_synonym: acute hepatitis
has_narrow_synonym: acute/subac. necrosis of liver
has_narrow_synonym: animal hepatitis
has_narrow_synonym: chronic hepatitis
has_narrow_synonym: chronic persistent hepatitis
has_related_synonym: Hepatitides
id: MONDO:0002251

digestive system disease
type: Class
subclass of: disease
definition: A disease or disorder that involves the digestive system.
imported from: mondo.owl
conforms to: location.yaml
conforms to: location top.yaml
database cross reference: COHD:4201745
database cross reference: DOID:77
database cross reference: EFO:0000405
database cross reference: ICD10:K92.9
database cross reference: ICD9:520-579.99
database cross reference: ICD9:V47.3
database cross reference: MESH:D005767
database cross reference: NCIT:C2990
database cross reference: SCTID:53619000
has exact synonym: alimentary system disease
has exact synonym: digestive disease
has exact synonym: digestive system disease
has exact synonym: digestive system disease or disorder
has exact synonym: digestive system disorder
has exact synonym: disease of digestive system
has exact synonym: disease or disorder of digestive system
has exact synonym: disorder of digestive system
has exact synonym: gastroenterological system disease
has exact synonym: gastroenterological system disorder
has exact synonym: gastroenteropathy
has exact synonym: gastrointestinal disease
has exact synonym: gastrointestinal disorder
has exact synonym: gastrointestinal system disease
has exact synonym: gastrointestinal system disorder
has exact synonym: git disease
has exact synonym: stomach or intestinal disorder
id: MONDO:0004335

diabetes mellitus (disease)
type: Class
subclass of: digestive system disease
subclass of: endocrine system disease
subclass of: disorder by anatomical region
subclass of: Restriction
  on property: isRiskFactorFor
  some values from: Alzheimer's disease
definition: A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.
imported from: mondo.owl
database cross reference: COHD:201820
database cross reference: DOID:9351
database cross reference: EFO:0000400
database cross reference: HP:0000819
database cross reference: ICD10:E08-E13
database cross reference: ICD10:E10.E14
database cross reference: ICD10:E11
database cross reference: ICD9:250
database cross reference: MESH:D003920
database cross reference: NCIT:C2985
database cross reference: SCTID:73211009
database cross reference: UMLS:C0011847
database cross reference: UMLS:C0011849
has exact synonym: DM
has exact synonym: diabetes
has exact synonym: diabetes mellitus
id: MONDO:0005015

endocrine system disease
type: Class
subclass of: disease
definition: A disease involving the endocrine system.
imported from: mondo.owl
conforms to: location.yaml
conforms to: location top.yaml
database cross reference: DOID:28
database cross reference: EFO:0001379
database cross reference: ICD10:E34.9
database cross reference: ICD9:259.8
database cross reference: ICD9:259.9
database cross reference: MESH:D004700
database cross reference: NCIT:C3009
database cross reference: SCTID:362969004
database cross reference: UMLS:C0014130
has exact synonym: disease of endocrine system
has exact synonym: disease or disorder of endocrine system
has exact synonym: disorder of endocrine system
has exact synonym: endocrine disease
has exact synonym: endocrine disorder
has exact synonym: endocrine system disease
has exact synonym: endocrine system disease or disorder
has exact synonym: endocrine system disorder
has exact synonym: endocrinopathy
has exact synonym: thyroid or other glandular disorders
id: MONDO:0005151

Alzheimer disease type 1
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
imported from: mondo.owl
has_broad_synonym: early-onset familial form of Alzheimer disease
database cross reference: DOID:0080348
database cross reference: GARD:0009465
database cross reference: OMIM:104300
database cross reference: UMLS:C2931257
has_related_synonym: AD
has_related_synonym: AD1
has_related_synonym: Alzheimer disease
has_related_synonym: Alzheimer disease 1
has_related_synonym: Alzheimer disease, early-onset, with cerebral amyloid angiopathy
has_related_synonym: Alzheimer disease, familial, 1
has_related_synonym: Alzheimer disease, protection against
has_related_synonym: presenile and senile dementia
id: MONDO:0007088
in subset: gard rare

Alzheimer disease 2
type: Class
subclass of: familial Alzheimer disease
definition: An Alzheimer's disease that is characterized by an association of the apolipoprotein E E4 allele.
imported from: mondo.owl
excluded subClassOf: early-onset autosomal dominant Alzheimer disease
database cross reference: DOID:0110035
database cross reference: GARD:0009467
database cross reference: ICD10:G30
database cross reference: MESH:C536595
database cross reference: OMIM:104310
database cross reference: UMLS:C1863051
has exact synonym: AD2
has exact synonym: Alzheimer disease 2
has exact synonym: Alzheimer disease 2, late onset
has exact synonym: Alzheimer disease associated with APOE4
has exact synonym: Alzheimer disease type 2
has exact synonym: Alzheimer disease-2
has exact synonym: Alzheimer's disease 2
has exact synonym: Alzheimer's disease type 2
has_related_synonym: Alzheimer disease 2, late-onset
has_related_synonym: Alzheimer disease associated with APOE E4
has_related_synonym: Alzheimer disease associated with Apoe4
has_related_synonym: LOFAD
has_related_synonym: late onset Alzheimer disease
has_related_synonym: late onset familial Alzheimer disease
id: MONDO:0007089

senile plaque formation
type: Class
subclass of: pathological process
imported from: mondo.owl
database cross reference: OMIM:269800
has exact synonym: senile plaque formation
id: MONDO:0010022

Alzheimer disease 16
type: Class
subclass of: Alzheimer's disease
definition: An Alzheimer's disease that is characterized by an associated with a risk allele in in the PCDH11X gene on chromosome Xq21.3.
imported from: mondo.owl
database cross reference: DOID:0110036
database cross reference: MESH:C567463
database cross reference: OMIM:300756
database cross reference: UMLS:C2677888
has exact synonym: AD16
has exact synonym: Alzheimer disease 16
has exact synonym: Alzheimer's disease 16
has exact synonym: Alzheimer's disease type 16
id: MONDO:0010422

Alzheimer disease, susceptibility to, mitochondrial
type: Class
subclass of: Alzheimer's disease
imported from: mondo.owl
database cross reference: OMIM:502500
has exact synonym: Alzheimer disease, susceptibility to, mitochondrial
id: MONDO:0010783
in subset: predisposition

Alzheimer disease 5
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
imported from: mondo.owl
database cross reference: DOID:0110037
database cross reference: ICD10:G30
database cross reference: MESH:C566578
database cross reference: OMIM:602096
database cross reference: UMLS:C1865868
has exact synonym: AD5
has exact synonym: Alzheimer disease 5
has exact synonym: Alzheimer disease type 5
has exact synonym: Alzheimer disease, familial 5
has exact synonym: Alzheimer's disease type 5
has_related_synonym: Ad5
has_related_synonym: Alzheimer disease, familial, 5
has_related_synonym: Alzheimer's disease 5
id: MONDO:0011194

Alzheimer disease without neurofibrillary tangles
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
imported from: mondo.owl
database cross reference: DOID:0110048
database cross reference: GARD:0007190
database cross reference: ICD10:G30
database cross reference: MESH:C536599
database cross reference: MESH:C566998
database cross reference: OMIM:604154
database cross reference: OMIM:611155
database cross reference: UMLS:C1858751
database cross reference: UMLS:C1970143
has exact synonym: AD15
has exact synonym: Alzheimer disease 15
has exact synonym: Alzheimer disease without neurofibrillary tangles
has exact synonym: Alzheimer's disease 15
has exact synonym: Alzheimer's disease type 15
has_related_synonym: Alzheimer's disease without neurofibrillary tangles
id: MONDO:0011401

Alzheimer disease, familial early-onset, with coexisting amyloid and prion pathology
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
imported from: mondo.owl
database cross reference: MESH:C565728
database cross reference: OMIM:605055
database cross reference: UMLS:C1857933
has exact synonym: Alzheimer disease, familial early-onset, with coexisting amyloid and prion pathology
id: MONDO:0011513

Alzheimer disease 6
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
definition: An Alzheimer's disease that is characterized by an associated with variation in the region 10q24.
imported from: mondo.owl
database cross reference: DOID:0110038
database cross reference: ICD10:G30
database cross reference: MESH:C565325
database cross reference: OMIM:605526
has exact synonym: AD6
has exact synonym: Alzheimer disease 6
has exact synonym: Alzheimer disease 6, late onset
has exact synonym: Alzheimer disease type 6
has exact synonym: Alzheimer's disease 6
has exact synonym: Alzheimer's disease type 6
has_related_synonym: Alzheimer disease 6, late-onset
has_related_synonym: plasma Beta-amyloid-42 level quantitative trait locus
id: MONDO:0011561

Alzheimer disease 7
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
definition: An Alzheimer's disease that is characterized by an associated with variation in the region 10p13.
imported from: mondo.owl
database cross reference: DOID:0110039
database cross reference: ICD10:G30
database cross reference: MESH:C565251
database cross reference: OMIM:606187
database cross reference: UMLS:C1853555
has exact synonym: AD7
has exact synonym: Alzheimer disease 7
has exact synonym: Alzheimer disease type 7
has exact synonym: Alzheimer disease, familial 7
has exact synonym: Alzheimer's disease 7
has exact synonym: Alzheimer's disease type 7
has_related_synonym: Ad7
has_related_synonym: Alzheimer disease, familial, 7
id: MONDO:0011647

Alzheimer disease 4
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
definition: Alzheimer's disease with an early onset (starts before the age of 65). It is caused by mutations in the PSEN2 gene.
imported from: mondo.owl
database cross reference: DOID:0110040
database cross reference: GARD:0009469
database cross reference: MESH:C536596
database cross reference: NCIT:C123413
database cross reference: OMIM:606889
database cross reference: UMLS:C1847200
has exact synonym: AD4
has exact synonym: Alzheimer disease 4
has exact synonym: Alzheimer disease type 4
has exact synonym: Alzheimer disease, familial4
has exact synonym: Alzheimer's disease 4
has exact synonym: Alzheimer's disease type 4
has exact synonym: familial Alzheimer disease, type 4
has exact synonym: familial Alzheimer's disease, type 4
has_related_synonym: Ad4
has_related_synonym: Alzheimer disease familial type 4
has_related_synonym: Alzheimer disease, familial, 4
id: MONDO:0011743

Alzheimer disease 8
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
definition: An Alzheimer's disease that is characterized by an associated with variation in the region 20p12.2-q11.21.
imported from: mondo.owl
database cross reference: DOID:0110041
database cross reference: ICD10:G30
database cross reference: MESH:C564622
database cross reference: OMIM:607116
database cross reference: UMLS:C1846735
has exact synonym: AD8
has exact synonym: Alzheimer disease 8
has exact synonym: Alzheimer disease type 8
has exact synonym: Alzheimer disease, familial 8
has exact synonym: Alzheimer's disease 8
has exact synonym: Alzheimer's disease type 8
has_related_synonym: Ad8
has_related_synonym: Alzheimer disease, familial, 8
id: MONDO:0011777

Alzheimer disease 3
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
definition: Alzheimer's disease with an early onset (starts before the age of 65). It is caused by mutations in the PSEN1 gene.
imported from: mondo.owl
conforms to: specific disease by dysfunctional structure.yaml
database cross reference: DOID:0110042
database cross reference: GARD:0009468
database cross reference: MESH:C536598
database cross reference: NCIT:C123412
database cross reference: OMIM:607822
has exact synonym: AD3
has exact synonym: Alzheimer disease 3
has exact synonym: Alzheimer disease 3, early onset
has exact synonym: Alzheimer disease familial 3
has exact synonym: Alzheimer disease type 3
has exact synonym: Alzheimer's disease 3
has exact synonym: Alzheimer's disease type 3
has exact synonym: PSEN1 early-onset autosomal dominant Alzheimer disease
has exact synonym: early-onset autosomal dominant Alzheimer disease caused by mutation in PSEN1
has exact synonym: familial Alzheimer disease, type 3
has exact synonym: familial Alzheimer's disease, type 3
has_related_synonym: AD
has_related_synonym: Alzheimer disease 3, early-onset
has_related_synonym: Alzheimer disease early onset type 3
has_related_synonym: Alzheimer disease, familial, 3
has_related_synonym: Alzheimer disease, familial, 3, with spastic paraparesis and apraxia
has_related_synonym: Alzheimer disease, familial, 3, with spastic paraparesis and unusual plaques
id: MONDO:0011913

Alzheimer disease 10
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
definition: An Alzheimer's disease that is characterized by an associated with variation in the region 7q36.
imported from: mondo.owl
database cross reference: DOID:0110043
database cross reference: ICD10:G30
database cross reference: MESH:C566465
database cross reference: OMIM:609636
database cross reference: UMLS:C1864828
has exact synonym: AD10
has exact synonym: Alzheimer disease 10
has exact synonym: Alzheimer disease familial 10
has exact synonym: Alzheimer disease type 10
has exact synonym: Alzheimer's disease 10
has exact synonym: Alzheimer's disease type 10
has_related_synonym: Ad10
has_related_synonym: Alzheimer disease, familial, 10
id: MONDO:0012321

Alzheimer disease 11
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
definition: An Alzheimer's disease that is characterized by an associated with variation in the region 9p22.1.
imported from: mondo.owl
database cross reference: DOID:0110044
database cross reference: ICD10:G30
database cross reference: MESH:C565228
database cross reference: OMIM:609790
database cross reference: UMLS:C1853360
has exact synonym: AD11
has exact synonym: Alzheimer disease 11
has exact synonym: Alzheimer disease type 11
has exact synonym: Alzheimer's disease 11
has exact synonym: Alzheimer's disease type 11
has_related_synonym: Ad11
has_related_synonym: Alzheimer disease, familial, 11
id: MONDO:0012344

Alzheimer disease 12
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
definition: An Alzheimer's disease that is characterized by an associated with variation in the region 8p12-q22.
imported from: mondo.owl
database cross reference: DOID:0110045
database cross reference: ICD10:G30
database cross reference: MESH:C567022
database cross reference: OMIM:611073
database cross reference: UMLS:C1970209
has exact synonym: AD12
has exact synonym: Alzheimer disease 12
has exact synonym: Alzheimer disease familial 12
has exact synonym: Alzheimer disease type 12
has exact synonym: Alzheimer's disease 12
has exact synonym: Alzheimer's disease type 12
has_related_synonym: Ad12
has_related_synonym: Alzheimer disease, familial, 12
id: MONDO:0012609

Alzheimer disease 13
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
definition: An Alzheimer's disease that is characterized by an associated with variation in the region 1q21.
imported from: mondo.owl
database cross reference: DOID:0110046
database cross reference: ICD10:G30
database cross reference: MESH:C567000
database cross reference: OMIM:611152
database cross reference: UMLS:C1970147
has exact synonym: AD13
has exact synonym: Alzheimer disease 13
has exact synonym: Alzheimer's disease 13
has exact synonym: Alzheimer's disease type 13
id: MONDO:0012630

Alzheimer disease 14
type: Class
subclass of: early-onset autosomal dominant Alzheimer disease
definition: An Alzheimer's disease that is characterized by an associated with variation in the region 1q25.
imported from: mondo.owl
database cross reference: DOID:0110047
database cross reference: ICD10:G30
database cross reference: MESH:C566999
database cross reference: OMIM:611154
database cross reference: UMLS:C1970144
has exact synonym: AD14
has exact synonym: Alzheimer disease 14
has exact synonym: Alzheimer's disease 14
has exact synonym: Alzheimer's disease type 14
id: MONDO:0012631

Alzheimer disease 17
type: Class
subclass of: Alzheimer's disease
definition: An Alzheimer's disease that is characterized by an associated with mutations in the gene TREM2.
imported from: mondo.owl
database cross reference: DOID:0110049
database cross reference: OMIM:615080
database cross reference: UMLS:C3554452
has exact synonym: AD17
has exact synonym: Alzheimer disease 17
has exact synonym: Alzheimer disease 17, late onset
has exact synonym: Alzheimer's disease 17
has exact synonym: Alzheimer's disease type 17
has_related_synonym: Alzheimer disease 17, late-onset
id: MONDO:0014036

Alzheimer disease 18
type: Class
subclass of: Alzheimer's disease
definition: Any Alzheimer disease in which the cause of the disease is a mutation in the ADAM10 gene.
imported from: mondo.owl
conforms to: specific disease by dysfunctional structure.yaml
database cross reference: DOID:0110050
database cross reference: OMIM:615590
database cross reference: UMLS:C3810041
has exact synonym: AD18
has exact synonym: ADAM10 Alzheimer disease
has exact synonym: Alzheimer disease 18
has exact synonym: Alzheimer disease caused by mutation in ADAM10
has exact synonym: Alzheimer disease type 18
has exact synonym: Alzheimer's disease 18
has exact synonym: Alzheimer's disease type 18
has_related_synonym: Alzheimer disease 18, late-onset
id: MONDO:0014265

Alzheimer disease 19
type: Class
subclass of: Alzheimer's disease
definition: Any Alzheimer disease in which the cause of the disease is a mutation in the PLD3 gene.
imported from: mondo.owl
conforms to: specific disease by dysfunctional structure.yaml
database cross reference: DOID:0110051
database cross reference: OMIM:615711
database cross reference: UMLS:C3810349
has exact synonym: AD19
has exact synonym: Alzheimer disease 19
has exact synonym: Alzheimer disease 19 late onset
has exact synonym: Alzheimer disease caused by mutation in PLD3
has exact synonym: Alzheimer disease type 19
has exact synonym: Alzheimer's disease 19
has exact synonym: Alzheimer's disease type 19
has exact synonym: PLD3 Alzheimer disease
has_related_synonym: Alzheimer disease 19, late-onset
id: MONDO:0014316

early-onset autosomal dominant Alzheimer disease
type: Class
subclass of: familial Alzheimer disease
definition: Early-onset autosomal dominant Alzheimer disease (EOAD) is a progressive dementia with reduction of cognitive functions. EOAD presents the same phenotype as sporadic Alzheimer disease (AD) but has an early age of onset, usually before 60 years old.
imported from: mondo.owl
database cross reference: GARD:0012798
database cross reference: ICD10:G30.0
database cross reference: Orphanet:1020
database cross reference: UMLS:CN043596
has exact synonym: EOFAD
has exact synonym: early-onset familial autosomal dominant Alzheimer disease
has_related_synonym: early-onset, autosomal dominant Alzheimer disease
id: MONDO:0015140
in subset: clingen
in subset: gard rare
in subset: ordo disease

corticobasal syndrome
type: Class
subclass of: neurodegenerative disease
definition: Corticobasal syndrome (CBS) is a rare neurodegenerative disease characterized by multifaceted motor system dysfunctions and cognitive defects such as asymmetric rigidity, bradykinesia, limb apraxia, and visuospatial dysfunction.
imported from: mondo.owl
database cross reference: ICD10:G31.0
database cross reference: Orphanet:454887
database cross reference: UMLS:CN237765
id: MONDO:0018696
in subset: ordo disease

corticobasal degeneration
type: Class
subclass of: neurodegenerative disease
subclass of: central nervous system disease
imported from: mondo.owl
database cross reference: SCTID:18842008
has exact synonym: corticobasal degeneration
has_related_synonym: cortical basal ganglionic degeneration
has_related_synonym: corticodentatonigral degeneration with neuronal achromasia
id: MONDO:0022880

disorder by anatomical region
type: Class
subclass of: disease
definition: A broad grouping of diseases based on major body subdivisions.
imported from: mondo.owl
database cross reference: SCTID:123946008
database cross reference: UMLS:C1290853
has_related_synonym: disease by body site
has_related_synonym: disease of organism subdivision
has_related_synonym: disorder by body site
has_related_synonym: disorder of anatomical
has_related_synonym: disorder of organism subdivision
id: MONDO:0024505
in subset: metaclass

familial Alzheimer disease
type: Class
subclass of: Alzheimer's disease
definition: A degenerative disease of the brain that causes gradual loss of memory, judgment, and the ability to function socially. About 25% of all Alzheimer disease is familial (more than 2 people in a family have AD). When Alzheimer disease begins before 60 or 65 years of age (early-onset AD) about 60% of the cases are familial (also known as Early-onset familial AD). These cases appear to be inherited in an autosomal dominant manner.
imported from: mondo.owl
created by: http://orcid.org/0000-0001-5208-3432
has exact synonym: Alzheimer disease, familial
has exact synonym: FAD
has exact synonym: GARD:0000632
id: MONDO:0100087

late-onset familial alzheimer disease
type: Class
subclass of: familial Alzheimer disease
definition: A form of familial Alzheimer disease, that begins after age 65.
imported from: mondo.owl
database cross reference: GARD:0012799
has exact synonym: Alzheimer disease type 2
id: MONDO:0100088

acetylation
type: Class
subclass of: formation of covalent bond
definition: Formation of a covalent bond between a substrate and an acetyl group.
imported from: mop.owl
has exact synonym: acetylation
id: MOP:0000030
comment: has_participant: CHEBI:40574

molecular process
type: Class
subclass of: process
definition: A process in which at least one of the participants is a molecule.
imported from: mop.owl
id: MOP:0000543
comment: TODO: needs work, formal definition, etc.

metal chelation
type: Class
subclass of: formation of covalent bond
definition: The formation of at least two single bonds between a metal atom and a ligand.
imported from: mop.owl
created by: batchelorc
creation date: 2009-08-14T09:55:35Z
has_narrow_synonym: metal ion chelation
id: MOP:0000604

deamination
type: Class
subclass of: molecular process
definition: Breaking of a covalent bond between a substrate and an amino group.
imported from: mop.owl
id: MOP:0000651

formation of covalent bond
type: Class
subclass of: molecular process
definition: A molecular process in which a covalent bond is formed.
imported from: mop.owl
id: MOP:0000779

deacetylation
type: Class
subclass of: molecular process
definition: Breaking of a covalent bond between a substrate and an acetyl group.
imported from: mop.owl
id: MOP:0001030
comment: has_participant: CHEBI:40574

decarbonylation
type: Class
subclass of: molecular process
definition: Breaking of a covalent bond between a substrate and a carbonyl group.
imported from: mop.owl
id: MOP:0001494
comment: has_participant: CHEBI:23019

atrophy
type: Class
subclass of: pathological process
definition: A reduction in size of organs or tissues as a result of cell death, loss of cellularity of whatever cause, reduced cellular proliferation or decreased cellular volume.
imported from: mpath.owl
has_obo_namespace: mouse_pathology.ontology
id: MPATH:127

apoptosis
type: Class
subclass of: cellular process
subclass of: pathological process
definition: Energy dependent cell death induced by intrinsic genetic or developmental programme, or external stimuli such as addition or withdrawal of cytokines or trophic factors, radiation, chemotherapeutic agents etc. Characterised by cell shrinkage, increases in membrane permeability, endonucleolyis and nuclear fragmentation resulting in the formation of rapidly endocytosed apoptotic bodies.
imported from: mpath.owl
has_obo_namespace: mouse_pathology.ontology
has_related_synonym: programmed cell death
id: MPATH:3

pathological process
type: Class
subclass of: biological_process
definition: The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion.
imported from: mpath.owl
has_obo_namespace: mouse_pathology.ontology
id: MPATH:596

demyelination
type: Class
subclass of: Abnormal nervous system physiology
definition: a partial absence or patchy, incomplete area of a myelin sheath over all or part of an axon or fiber tract due to degeneration or destruction of the myelin sheath
imported from: mp.owl
has_alternative_id: MP:0010049
has exact synonym: myelin degeneration
has exact synonym: myelin destruction
has_obo_namespace: MPheno.ontology
id: MP:0000921
comment: Demyelination is a term used to describe the destruction of the myelin sheath that surrounds axonal fibres. This is caused by diseases that damage the myelin sheath or the cells that form it.

vascular inflammation
type: Class
subclass of: Abnormality of immune system physiology
definition: inflammation of any blood and/or lymphatic vessel
imported from: mp.owl
has exact synonym: vessel inflammation
has_obo_namespace: MPheno.ontology
id: MP:0001864

oxidative stress
type: Class
subclass of: pathological process
definition: condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma
imported from: mp.owl
has_obo_namespace: MPheno.ontology
has_related_synonym: increased ROS production
has_related_synonym: increased reactive oxygen species production
id: MP:0003674

insulin resistance
type: Class
subclass of: nutrition, metabolism, and development symptom
definition: diminished effectiveness of insulin in lowering plasma glucose levels
imported from: mp.owl
has_obo_namespace: MPheno.ontology
id: MP:0005331

abnormal ceramide level
type: Class
subclass of: Phenotypic abnormality
definition: any anomaly in the concentration of the subclass of sphingoid base derivatives with an amide-linked fatty acid, where the fatty acids are typically saturated or monounsaturated with chain lengths from 14 to 26 carbon atoms
imported from: mp.owl
created by: csmith
creation date: 2013-11-11T15:00:49Z
has_obo_namespace: MPheno.ontology
id: MP:0012232

emotional behavior
type: Class
subclass of: behavior process
definition: "Behavior related to the complex psychophysiological experience of an individual's state of mind as interacting with biochemical (internal) and environmental (external) influences." [wikipedia:Emotions]
imported from: nbo.owl
date: 2011-04-14T01:03:39Z
created by: George Gkoutos
has exact synonym: affective behaviour
has exact synonym: mood
has_obo_namespace: behavior_ontology

impulsive behavior
type: Class
subclass of: behavior process
definition: "A behavior that occur quickly without control, planning, or consideration of the consequences of that behavior." [NBO:GVG]
imported from: nbo.owl
date: 2011-03-31T11:08:55Z
created by: George Gkoutos
has_obo_namespace: behavior_ontology

behavior process
type: Class
subclass of: bodily process
definition: "The action, reaction, or performance of an organism in response to external or internal stimuli." [GO:GO\:0007610]
imported from: nbo.owl
date: 2011-04-05T09:53:10Z
created by: George Gkoutos
has_alternative_id: NBO:0000000
has exact synonym: behavior
has exact synonym: behaviour
has_obo_namespace: behavior_ontology
xref: GO:0007610

cognitive behavior
type: Class
subclass of: behavior process
definition: "Behaviour related to cognitive processes." [NBO:JH]
imported from: nbo.owl
date: 2011-04-14T03:51:13Z
created by: George Gkoutos
has_obo_namespace: behavior_ontology

consumption behavior
type: Class
subclass of: behavior process
definition: "Behavior related to the intake of substances." [NBOC:GVG]
imported from: nbo.owl
created by: George Gkoutos
has_broad_synonym: ingest

nicotine consumption
type: Class
subclass of: Lifestyle
definition: "Behavior related to the intake of nicotine." [NBOC:GVG]
imported from: nbo.owl
created by: George Gkoutos

root
type: Class
subclass of: material entity
imported from: ncbitaxon.owl
database cross reference: GC_ID:1
has_obo_namespace: ncbi_taxonomy
has_related_synonym: all

Rattus
type: Class
subclass of: Animal Model
imported from: ncbitaxon.owl
has_rank: NCBITaxon genus
database cross reference: GC_ID:1
has exact synonym: rat
has exact synonym: rats
has_obo_namespace: ncbi_taxonomy

cellular organisms
type: Class
subclass of: root
definition: A cellular organism is an organism that contains one or more cells.
imported from: ncbitaxon.owl
database cross reference: GC_ID:1
has_obo_namespace: ncbi_taxonomy
has_related_synonym: biota

Axiom
annotated source: cellular organisms
annotated property: definition
annotated target: A cellular organism is an organism that contains one or more cells.

Curcuma longa
type: Class
subclass of: herbal medicine
imported from: ncbitaxon.owl
has_rank: NCBITaxon species
database cross reference: GC_ID:1
has exact synonym: turmeric
has_obo_namespace: ncbi_taxonomy
has_related_synonym: Curcuma domestica

herbal medicine
type: Class
subclass of: treatment
imported from: ncbitaxon.owl
has_rank: NCBITaxon species
database cross reference: GC_ID:1
has_obo_namespace: ncbi_taxonomy

Eukaryota
type: Class
subclass of: cellular organisms
definition: One of the three domains of life (the others being bacteria and archea), also called Eukarya. These are organisms whose cells are enclosed in membranes and possess a nucleus. They comprise almost all multicellular and many unicellular organisms, and are traditionally divided into groups (sometimes called kingdoms) including Animals; plants; fungi; and various algae and other taxa that were previously part of the old kingdom Protista.
imported from: ncbitaxon.owl
has_rank: NCBITaxon superkingdom
database cross reference: GC_ID:1
database cross reference: PMID:23020233
database cross reference: PMID:30257078
has exact synonym: eucaryotes
has exact synonym: eukaryotes
has_obo_namespace: ncbi_taxonomy
has_related_synonym: Eucarya
has_related_synonym: Eucaryotae
has_related_synonym: Eukarya
has_related_synonym: Eukaryotae
has_related_synonym: eukaryotes

Axiom
annotated source: Eukaryota
annotated property: definition
annotated target: One of the three domains of life (the others being bacteria and archea), also called Eukarya. These are organisms whose cells are enclosed in membranes and possess a nucleus. They comprise almost all multicellular and many unicellular organisms, and are traditionally divided into groups (sometimes called kingdoms) including Animals; plants; fungi; and various algae and other taxa that were previously part of the old kingdom Protista.

Ginkgo biloba
type: Class
subclass of: herbal medicine
imported from: ncbitaxon.owl
has_rank: NCBITaxon species
has_alternative_id: NCBITaxon:488673
database cross reference: GC_ID:1
has exact synonym: ginkgo
has exact synonym: maidenhair tree
has_obo_namespace: ncbi_taxonomy
has_related_synonym: Ginkgo biloba f. epiphylla
has_related_synonym: Ginkgo biloba var. epiphylla

Lavandula
type: Class
subclass of: herbal medicine
imported from: ncbitaxon.owl
has_rank: NCBITaxon genus
database cross reference: GC_ID:1
has exact synonym: lavenders
has_obo_namespace: ncbi_taxonomy

Mammalia
type: Class
subclass of: Vertebrata <vertebrates>
definition: Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young.
imported from: ncbitaxon.owl
has_rank: NCBITaxon class
database cross reference: GC_ID:1
has exact synonym: mammals
has_obo_namespace: ncbi_taxonomy
has_related_synonym: mammals

Axiom
annotated source: Mammalia
annotated property: definition
annotated target: Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young.

Caenorhabditis elegans
type: Class
subclass of: Animal Model
imported from: ncbitaxon.owl
has_rank: NCBITaxon species
database cross reference: GC_ID:1
has exact synonym: roundworm
has_obo_namespace: ncbi_taxonomy
has_related_synonym: Rhabditis elegans

Drosophila <flies,genus>
type: Class
subclass of: Animal Model
imported from: ncbitaxon.owl
has_rank: NCBITaxon genus
has_alternative_id: NCBITaxon:7326
database cross reference: GC_ID:1
has exact synonym: Drosophila
has exact synonym: fruit flies
has exact synonym: fruit fly
has_obo_namespace: ncbi_taxonomy

Vertebrata <vertebrates>
type: Class
subclass of: Eukaryota
definition: Animals having a vertebral column, members of the phylum Chordata, subphylum Craniata comprising mammals, birds, reptiles, amphibians, and fishes.
imported from: ncbitaxon.owl
has_rank: NCBITaxon clade
database cross reference: GC_ID:1
has exact synonym: Vertebrata
has exact synonym: vertebrates
has_obo_namespace: ncbi_taxonomy
has_related_synonym: vertebrates

Axiom
annotated source: Vertebrata <vertebrates>
annotated property: definition
annotated target: Animals having a vertebral column, members of the phylum Chordata, subphylum Craniata comprising mammals, birds, reptiles, amphibians, and fishes.

Danio rerio
type: Class
subclass of: Animal Model
imported from: ncbitaxon.owl
has_rank: NCBITaxon species
has_alternative_id: NCBITaxon:27702
has_alternative_id: NCBITaxon:37966
database cross reference: GC_ID:1
has exact synonym: leopard danio
has exact synonym: zebra danio
has exact synonym: zebra fish
has exact synonym: zebrafish
has_obo_namespace: ncbi_taxonomy
has_related_synonym: Brachydanio rerio
has_related_synonym: Brachydanio rerio frankei
has_related_synonym: Cyprinus rerio
has_related_synonym: Danio frankei
has_related_synonym: Danio rerio frankei

Homo sapiens
type: Class
subclass of: Mammalia
definition: The primate species of mammal to which modern humans belong.
imported from: ncbitaxon.owl
has_rank: NCBITaxon species
database cross reference: GC_ID:1
has exact synonym: human
has exact synonym: man
has_obo_namespace: ncbi_taxonomy
has_related_synonym: Home sapiens
has_related_synonym: Homo sampiens
has_related_synonym: Homo sapeins
has_related_synonym: Homo sapian
has_related_synonym: Homo sapians
has_related_synonym: Homo sapien
has_related_synonym: Homo sapience
has_related_synonym: Homo sapiense
has_related_synonym: Homo sapients
has_related_synonym: Homo sapines
has_related_synonym: Homo spaiens
has_related_synonym: Homo spiens
has_related_synonym: Humo sapiens

Axiom
annotated source: Homo sapiens
annotated property: definition
annotated target: The primate species of mammal to which modern humans belong.

Alzheimer's Disease Assessment Scale-Cognitive CDISC Version Questionnaire
type: Class
subclass of: Clinical or Research Assessment Questionnaire
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: The CDISC version of the Alzheimer's Disease Assessment Scale-Cognitive (CDISC ADAS-Cog) containing 15 summary-level tests. This version is based on combining the total pool of ADAS-Cog tests that were observed during a review of multiple case report forms administered in clinical trials of Alzheimer's disease, as well as the CRF administered in the Alzheimer's Disease Neuroimaging Initiative (ADNI) observational study. (Modified from Mohs RC, Rosen WG, Davis KL. The Alzheimer's disease assessment scale: an instrument for assessing treatment efficacy. Psychopharmacol Bull 1983;19(3):448-450. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984;141(11):1356-1364. Mohs RC, Knopman D, Petersen RC et al. Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 1997;11 Suppl 2:S13-S21. Wouters H, van Gool WA, Schmand B, Lindeboom R. Revising the ADAS-cog for a more accurate assessment of cognitive impairment. Alzheimer Dis Assoc Disord 2008;22(3):236-244.).
imported from: ncit.owl
code: C100762
Semantic_Type: Intellectual Product
Preferred_Name: Alzheimer's Disease Assessment Scale-Cognitive CDISC Version Questionnaire
UMLS_CUI: C3539026
Contributing_Source: CDISC
ALT_DEFINITION: The CDISC version of the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog CDISC Version) containing 15 summary-level tests. This version is based on combining the total pool of ADAS-Cog tests that were observed during a review of multiple case report forms administered in clinical trials of Alzheimer's disease, as well as the CRF administered in the Alzheimer's Disease Neuroimaging Initiative (ADNI) observational study. (Modified from Mohs RC, Rosen WG, Davis KL. The Alzheimer's disease assessment scale: an instrument for assessing treatment efficacy. Psychopharmacol Bull 1983;19(3):448-450. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984;141(11):1356-1364. Mohs RC, Knopman D, Petersen RC et al. Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 1997;11 Suppl 2:S13-S21. Wouters H, van Gool WA, Schmand B, Lindeboom R. Revising the ADAS-cog for a more accurate assessment of cognitive impairment. Alzheimer Dis Assoc Disord 2008;22(3):236-244.).
has exact synonym: ADAS-COG
has exact synonym: ADC
has exact synonym: Alzheimer's Disease Assessment Scale-Cognitive CDISC Version Questionnaire
in subset: NCIT C100110
in subset: NCIT C100129
in subset: NCIT C120166
in subset: NCIT C61410
in subset: NCIT C66830

Clinical Dementia Rating Questionnaire
type: Class
subclass of: Clinical or Research Assessment Questionnaire
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A standardized rating scale developed by John C. Morris in 1997 to evaluate the severity of an individual's cognitive impairment. This instrument contains 6 areas which include memory, orientation, judgment and problem solving, community affairs, home and hobbies, and personal care. Each item is rated on a scale from 0 to 3 with 0 being none and 3 being severe.
imported from: ncit.owl
code: C102114
Semantic_Type: Intellectual Product
Preferred_Name: Clinical Dementia Rating Questionnaire
UMLS_CUI: C0451074
Contributing_Source: CDISC
ALT_DEFINITION: Clinical Dementia Rating (CDR) (Morris, JC. Clinical Dementia Rating: A reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. International Psychogeriatrics 1997: 9, Suppl. 1, 173-176).
has exact synonym: CDR
has exact synonym: CDR01
has exact synonym: Clinical Dementia Rating Questionnaire
in subset: NCIT C100110
in subset: NCIT C100129
in subset: NCIT C120166
in subset: NCIT C61410
in subset: NCIT C66830

FDG-Positron Emission Tomography
type: Class
subclass of: imaging technique
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: An imaging technique that utilizes positron emission tomography to produce a three-dimensional image of functional processes in the body. The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on the biologically active molecule (fludeoxyglucose) FDG. FDG is an analogue of glucose which when imaged will give tissue metabolic activity, in terms of regional glucose uptake.
imported from: ncit.owl
code: C103400
Semantic_Type: Diagnostic Procedure
Display_Name: FDG-Positron Emission Tomography
Preferred_Name: FDG-Positron Emission Tomography
UMLS_CUI: C3641247
Contributing_Source: CTRP
Contributing_Source: NCCN
has exact synonym: FDG-PET
has exact synonym: FDG-PET Imaging
has exact synonym: FDG-Positron Emission Tomography
in subset: NCIT C116977
in subset: NCIT C118169

Disability Assessment for Dementia Questionnaire
type: Class
subclass of: Clinical or Research Assessment Questionnaire
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A standardized questionnaire developed by Gelinas et al in 1998, which is used to measure the changes in functional activities in patients with Alzheimer's disease. The questionnaire contains 40 items across 3 domains; basic activities of daily living, instrumental activities of daily living and leisure activities.
imported from: ncit.owl
code: C105165
Semantic_Type: Intellectual Product
Preferred_Name: Disability Assessment for Dementia Questionnaire
UMLS_CUI: C3641946
Contributing_Source: CDISC
ALT_DEFINITION: Disability Assessment for Dementia (DAD) (copyright 1994 by L. Gauthier I. Gelinas. All rights reserved.).
has exact synonym: DAD
has exact synonym: DAD01
has exact synonym: Disability Assessment for Dementia Questionnaire
in subset: NCIT C100110
in subset: NCIT C100129
in subset: NCIT C120166
in subset: NCIT C61410
in subset: NCIT C66830

Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory Questionnaire
type: Class
subclass of: Clinical or Research Assessment Questionnaire
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A standardized questionnaire developed by Galasko et al in 1997 as part of the Alzheimer's disease cooperative study, which is used to measure the performance of activities of daily living by patients diagnosed with Alzheimer's disease. The questionnaire contains 23 items (and a number of sub-items within the 23 main items) with a range of preset answers that are assigned points based on performance.
imported from: ncit.owl
code: C105166
Semantic_Type: Intellectual Product
Preferred_Name: Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory Questionnaire
UMLS_CUI: C3641947
Contributing_Source: CDISC
ALT_DEFINITION: Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) (Galasko, D., Bennett, D., Sano, M., Ernesto, C., Thomas, R., Grundman, M., Ferris, S., and the ADCS. "An Inventory to Assess Activities of Daily Living for Clinical Trials in Alzheimer's Disease." Alzheimer's Disease and Associated Disorders, 1997. Volume 11(2): S33-S39).
has exact synonym: ADCS-ADL
has exact synonym: ADL01
has exact synonym: Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory Questionnaire
in subset: NCIT C100110
in subset: NCIT C100129
in subset: NCIT C120166
in subset: NCIT C61410
in subset: NCIT C66830

Geriatric Depression Scale Questionnaire
type: Class
subclass of: Clinical or Research Assessment Questionnaire
definition: A standardized rating scale developed by Yesavage et al in 1983, which is a self-report assessment used to identify depression in older adults. The questionnaire contains 30 items. All questions are answered 'yes' or 'no'.
imported from: ncit.owl
code: C106697
Semantic_Type: Intellectual Product
Preferred_Name: Geriatric Depression Scale Questionnaire
UMLS_CUI: C0451184
Contributing_Source: CDISC
ALT_DEFINITION: Geriatric Depression Scale (GDS) (Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatry Res. 1983;17(1):37-49).
has exact synonym: GDS
has exact synonym: GDS01
has exact synonym: Geriatric Depression Scale Questionnaire
in subset: NCIT C100110
in subset: NCIT C100129
in subset: NCIT C120166
in subset: NCIT C61410
in subset: NCIT C66830

Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory Mild Cognitive Impairment Questionnaire
type: Class
subclass of: Clinical or Research Assessment Questionnaire
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A standardized questionnaire developed by Galasko et al in 1997 as part of the Alzheimer's disease cooperative study, which is used to measure the performance of activities of daily living by patients diagnosed with Alzheimer's disease, exhibiting evidence of mild cognitive impairment (MCI). The questionnaire contains 24 items (and a number of sub-items within the 24 main items) with a range of preset answers that are assigned points based on performance.
imported from: ncit.owl
code: C106888
Semantic_Type: Intellectual Product
Preferred_Name: Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory Mild Cognitive Impairment Questionnaire
UMLS_CUI: C3827035
Contributing_Source: CDISC
ALT_DEFINITION: Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL), MCI Version (Galasko, D., Bennett, D., Sano, M., Ernesto, C., Thomas, R., Grundman, M., Ferris, S., and the ADCS. An Inventory to Assess Activities of Daily Living for Clinical Trials in Alzheimer's Disease. Alzheimer's Disease and Associated Disorders, 1997. Volume 11(2): S33-S39).
has exact synonym: ADCS-ADL MCI
has exact synonym: ADL03
has exact synonym: Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory Mild Cognitive Impairment Questionnaire
in subset: NCIT C100110
in subset: NCIT C100129
in subset: NCIT C120166
in subset: NCIT C61410
in subset: NCIT C66830

Notch Receptor Intracellular Domain
type: Class
subclass of: material entity
definition: The free carboxy-terminal intracellular domain (ICD) of a notch family protein, which is a product of regulated intramembrane proteolysis mediated by the gamma-secretase enzyme complex. This protein fragment is involved in transcriptional regulation of target genes.
imported from: ncit.owl
code: C111794
Semantic_Type: Amino Acid, Peptide, or Protein
Preferred_Name: Notch Receptor Intracellular Domain
UMLS_CUI: C3828777
DesignNote: Full-length notch proteins are post-translationally cleaved by furin to produce a disulfide bound, two-chain protein that is expressed on the cell surface. Once a notch ligand binds the extracellular portion, the larger amino-terminal portion is released from the cell surface and the remaining portion of the receptor, termed the Notch extracellular truncated (NEXT) domain is endocytosed. During endocytosis, NEXT is cleaved sequentially by an ADAM family secretase followed by intramembrane cleavage by gamma-secretase, which allows the notch intracellular domain to dissociate from the membrane and translocate into the nucleus.
has exact synonym: NICD
has exact synonym: Neurogenic Locus Notch Homolog Protein ICD
has exact synonym: Neurogenic Locus Notch Homolog Protein Intracellular Domain
has exact synonym: Notch ICD
has exact synonym: Notch Intracellular Domain
has exact synonym: Notch Receptor Intracellular Domain

Arterial Spin Labeling Magnetic Resonance Imaging
type: Class
subclass of: Magnetic Resonance Imaging
definition: An application of functional MRI used to measure cerebral blood flow. ASL uses magnetically labeled water as the tracer.
imported from: ncit.owl
code: C116450
Semantic_Type: Diagnostic Procedure
Display_Name: Arterial Spin Labeling Magnetic Resonance Imaging
Preferred_Name: Arterial Spin Labeling Magnetic Resonance Imaging
NCI_META_CUI: CL446664
Contributing_Source: CDISC
Contributing_Source: CTRP
ALT_DEFINITION: A noninvasive fMRI technique that uses arterial water as an endogenous tracer to measure cerebral blood flow by magnetically labeling the proton spins of the arterial water prior to reaching the imaged volume.
has exact synonym: ARTERIAL SPIN LABELING FUNCTIONAL MRI
has exact synonym: ASL
has exact synonym: ASL fMRI
has exact synonym: Arterial Spin Labeling MRI
has exact synonym: Arterial Spin Labeling Magnetic Resonance Imaging
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C85492

Diagnostic Criteria
type: Class
subclass of: diagnosis
definition: A standard from which a judgment concerning a medical diagnosis can be established.
imported from: ncit.owl
code: C117960
Semantic_Type: Idea or Concept
Preferred_Name: Diagnostic Criteria
UMLS_CUI: C0679228
Contributing_Source: CDISC
ALT_DEFINITION: A standard from which a judgment concerning a medical diagnosis can be established.
has exact synonym: DXCRIT
has exact synonym: Diagnostic Criteria
in subset: NCIT C61410
in subset: NCIT C66738
in subset: NCIT C66830
in subset: NCIT C67152

Extrapyramidal Symptom Rating Scale-Abbreviated Clinical Classification
type: Class
subclass of: Research or Clinical Assessment Tool
definition: A standardized rating scale originally developed by Chouinard et al in 1980, which is used to measure drug-induced extrapyramidal symptoms (EPS) or 4 types of drug-induced movement disorders (DIMD): parkinsonism, akathisia, dystonia, and tardive dyskinesia. The questionnaire contains 28 questions and generates 4 subscales and 4 clinical global impression severity (CGI-S) scales.
imported from: ncit.owl
code: C117997
Semantic_Type: Intellectual Product
Preferred_Name: Extrapyramidal Symptom Rating Scale-Abbreviated Clinical Classification
UMLS_CUI: C3896675
Contributing_Source: CDISC
ALT_DEFINITION: Extrapyramidal Symptom Rating Scale-Abbreviated (ESRS-A) (Copyright 2006 Larry Alphs, MD, PhD, Guy Chouinard, MD, All Rights Reserved).
has exact synonym: ESRS-A
has exact synonym: ESRSA
has exact synonym: ESRSA1
has exact synonym: Extrapyramidal Symptom Rating Scale-Abbreviated Clinical Classification
in subset: NCIT C118970
in subset: NCIT C118971
in subset: NCIT C120166
in subset: NCIT C61410
in subset: NCIT C66830

N-Methyl-D-Aspartate Receptor
type: Class
subclass of: receptor
definition: A protein complex that plays a role in both NMDA binding and ion transport. It is a heterotetramer consisting of 2 glutamate [NMDA] receptor subunit zeta-1 proteins and 2 epsilon subunits (glutamate [NMDA] receptor subunit epsilon-1, -2, -3 or -4).
imported from: ncit.owl
code: C118457
Semantic_Type: Amino Acid, Peptide, or Protein
Preferred_Name: N-Methyl-D-Aspartate Receptor
UMLS_CUI: C0080093
has exact synonym: N-Methyl-D-Aspartate Receptor
has exact synonym: N-Methyl-D-aspartate receptor
has exact synonym: NMDA Receptor
has exact synonym: NMDAR

FOXO Family
type: Class
subclass of: Protein Family
definition: A subfamily within the forkhead box (FOX) protein family, which is a family of transcription factors that contain a forkhead DNA-binding domain. FOXO proteins regulate apoptosis, cell-cycle progression, oxidative-stress resistance, and tumor suppression. The transcriptional promoter activity of these factors is regulated by post-translational modifications, such as phosphorylation, acetylation, and monoubiquitination.
imported from: ncit.owl
code: C118892
Semantic_Type: Amino Acid, Peptide, or Protein
Display_Name: FOXO Family
Preferred_Name: FOXO Family
UMLS_CUI: C3899164
Contributing_Source: CTRP
DesignNote: There are four known members of the FOXO family expressed in humans. They are FOXO1, FOXO3, FOXO4 and FOXO6.
has exact synonym: FOXO
has exact synonym: FOXO Family
has exact synonym: Fork Head Box Transcription Factor Class O
has exact synonym: Forkhead Box Transcription Factor Class O
has exact synonym: FoxO
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

Phosphatidylinositol 4,5-bisphosphate
type: Class
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
definition: A phospholipid that is a component of the plasma membrane with signal transduction inducing activity. Phosphatidylinositol 4,5-bisphosphate (PIP2) is an intermediate that can be converted into either the second messenger signaling molecules, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), or phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3; PIP3). Both PIP2 and PIP3 can act as docking phospholipids, which recruit signaling proteins to the plasma membrane and promotes the activation of several signaling cascades.
imported from: ncit.owl
code: C1192
Semantic_Type: Biologically Active Substance
Semantic_Type: Organic Chemical
Preferred_Name: Phosphatidylinositol 4,5-bisphosphate
UMLS_CUI: C0070798
Legacy Concept Name: Phosphatidylinositol_4_5-bisphosphate
CHEBI_ID: CHEBI:18348
has exact synonym: 1,2-Diacyl-sn-Glycero-3-Phospho-(1'-myo-Inositol-4',5'-Bisphosphate)
has exact synonym: 1-O-(3-sn-Phosphatidyl)-1D-myo-Inositol 4,5-Bis(Dihydrogen Phosphate)
has exact synonym: 1-Phosphatidyl-1D-myo-Inositol 4,5-Bisphosphate
has exact synonym: 1-Phosphatidyl-D-myo-Inositol 4,5-Bisphosphate
has exact synonym: PIP2
has exact synonym: PIPP
has exact synonym: Phosphatidyl-myo-Inositol 4,5-Bisphosphate
has exact synonym: Phosphatidylinositol 4,5-Diphosphate
has exact synonym: Phosphatidylinositol 4,5-bisphosphate
has exact synonym: PtdIns(4,5)P2
has exact synonym: PtsIns-4,5-P2

California Verbal Learning Test - Second Edition
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: The second version of California Verbal Learning Test, a neuropsychological test developed to make a comprehensive and detailed assessment of verbal learning and memory in individuals ranging in age from 16 to 89 years.
imported from: ncit.owl
code: C120257
Semantic_Type: Intellectual Product
Preferred_Name: California Verbal Learning Test - Second Edition
UMLS_CUI: C3899729
has exact synonym: CVLT-II
has exact synonym: California Verbal Learning Test - Second Edition
has exact synonym: California Verbal Learning Test 2nd Edition
has exact synonym: California Verbal Learning Test II
has exact synonym: California Verbal Learning Test, Second Edition

Montreal Cognitive Assessment Functional Test
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A standardized rating scale developed by Ziad Nasreddine in 1996 to screen for mild cognitive dysfunction and impairment. This instrument assesses the following cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation.
imported from: ncit.owl
code: C123667
Semantic_Type: Intellectual Product
Preferred_Name: Montreal Cognitive Assessment Functional Test
UMLS_CUI: C3496286
Contributing_Source: CDISC
ALT_DEFINITION: Montreal Cognitive Assessment (MoCA) (Copyright Z. Nasreddine MD. Ziad S. Nasreddine, Natalie A. Phillips, Valerie Bedirian, Simon Charbonneau, Victor Whitehead, Isabelle Collin, Jeffrey L. Cummings and Howard Chertkow. The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment. J Am Geriatr Soc. 2005 Apr;53(4):695-9).
has exact synonym: MOCA
has exact synonym: MOCA01
has exact synonym: Montreal Cognitive Assessment
has exact synonym: Montreal Cognitive Assessment Functional Test
in subset: NCIT C115302
in subset: NCIT C115304
in subset: NCIT C120166
in subset: NCIT C61410
in subset: NCIT C66830

Rey Auditory Verbal Learning Functional Test
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A standardized rating scale modified from A. Rey in 1964 and Ceffen et al in 1994, which is used to evaluate verbal learning and memory abilities in both children and adults. The questionnaire contains 36 items and assesses overall memory performance, immediate span of memory for words, acquisition rate, interference effects, and recognition.
imported from: ncit.owl
code: C123668
Semantic_Type: Intellectual Product
Preferred_Name: Rey Auditory Verbal Learning Functional Test
UMLS_CUI: C4054062
Contributing_Source: CDISC
ALT_DEFINITION: Auditory Verbal Learning Test (AVLT-Rey) (Modified from Rey A. L'examen clinique en psychologie [Clinical tests in psychology]. Paris: Presses Universitaires de France; 1964. Test-Retest Reliability of a New Form of Auditory Verbal Learning Test (AVLT); Archives of Clinical Neuropsycology, Vol. 9, No. 4, pp. 303-316, 1994. Performance of Healthy Subjects and Patients with Resection from the Anterior Temporal Lobe on Matched Tests of Verbal and Visuoperceptual Learning; Journal of Clinical and Experimental Neuropsychology 1996, Vol. 18, No. 3, pp. 416-430).
has exact synonym: AVL02
has exact synonym: AVLT-REY
has exact synonym: Rey Auditory Verbal Learning Functional Test
in subset: NCIT C115302
in subset: NCIT C115304
in subset: NCIT C120166
in subset: NCIT C61410
in subset: NCIT C66830

Non-Granular Leukocyte
type: Class
subclass of: leukocyte
definition: A white blood cell that lacks cytoplasmic granules with an affinity for specific biological stains; typically, a lymphocyte, monocyte, or plasma cell.
imported from: ncit.owl
code: C12534
Semantic_Type: Cell
Display_Name: Leukocyte, Mononuclear
Preferred_Name: Non-Granular Leukocyte
UMLS_CUI: C0023517
ALT_DEFINITION: A type of white blood cell. Monocytes and lymphocytes are agranulocytes.
Legacy Concept Name: Non-Granular_Leukocyte
has exact synonym: Agranulocyte
has exact synonym: Mononuclear Leukocyte
has exact synonym: Non-Granular Leukocyte
has exact synonym: Non-Granular Leukocytes
has exact synonym: agranulocyte

Have Difficulty Swallowing
type: Class
subclass of: Clinical or Research Assessment Question
definition: A question about whether an individual has or had difficulty in swallowing.
imported from: ncit.owl
code: C125410
Semantic_Type: Intellectual Product
Preferred_Name: Have Difficulty Swallowing
UMLS_CUI: C4084787
NCI_META_CUI: CL972888
has exact synonym: Difficulty swallowing
has exact synonym: Had Trouble Swallowing
has exact synonym: Have Difficulty Swallowing
has exact synonym: Have you had trouble swallowing
has exact synonym: Trouble Swallowing
in subset: NCIT C125239
in subset: NCIT C168555

Have Indigestion
type: Class
subclass of: Clinical or Research Assessment Question
definition: A question about whether an individual has or had indigestion.
imported from: ncit.owl
code: C125913
Semantic_Type: Intellectual Product
Preferred_Name: Have Indigestion
NCI_META_CUI: CL504562
has exact synonym: Have Indigestion
has exact synonym: Have you had indigestion
in subset: NCIT C125906

Resting State Functional Connectivity Magnetic Resonance Imaging
type: Class
subclass of: Magnetic Resonance Imaging
definition: A technique that monitors blood oxygen level dependent (BOLD) signals to map brain regions that active while not performing any specific task.
imported from: ncit.owl
code: C129326
Semantic_Type: Diagnostic Procedure
Display_Name: Resting State Functional Connectivity Magnetic Resonance Imaging
Preferred_Name: Resting State Functional Connectivity Magnetic Resonance Imaging
NCI_META_CUI: CL512231
Contributing_Source: CTRP
has exact synonym: RS-fcMRI
has exact synonym: Resting State Functional Connectivity MRI
has exact synonym: Resting State Functional Connectivity Magnetic Resonance Imaging
has exact synonym: Resting fcMRI
in subset: NCIT C116977
in subset: NCIT C118169

Vascular Endothelial Growth Factor Family
type: Class
subclass of: Protein Family
definition: A sub-family of the cysteine knot platelet-derived growth factor family. Members of the vascular endothelial growth factor (VEGF) family play a role in the promotion of embryonic vasculogenesis and the stimulation of angiogenesis during physiologic and pathologic processes.
imported from: ncit.owl
code: C129646
Semantic_Type: Amino Acid, Peptide, or Protein
Display_Name: Vascular Endothelial Growth Factor Family
Preferred_Name: Vascular Endothelial Growth Factor Family
UMLS_CUI: C1256770
Contributing_Source: CTRP
DesignNote: There are five members of the VEGF family expressed in mammals: VEGF-A, placenta growth factor (PGF), VEGF-B, VEGF-C and VEGF-D.
has exact synonym: VEGF
has exact synonym: VEGF Family
has exact synonym: Vascular Endothelial Growth Factor
has exact synonym: Vascular Endothelial Growth Factor Family
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

MT-RNR2 Gene
type: Class
subclass of: RNA gene of Homo sapiens
definition: This gene plays a role in both mitochondrial protein translation and apoptosis regulation.
imported from: ncit.owl
code: C131258
OMIM_Number: 561010
Semantic_Type: Gene or Genome
Preferred_Name: MT-RNR2 Gene
UMLS_CUI: C1537997
HGNC_ID: HGNC:7471
has exact synonym: MT-RNR2
has exact synonym: MT-RNR2 Gene
has exact synonym: Mitochondrially Encoded 16S RNA Gene

Current Difficulty Learning New Tasks or Instructions
type: Class
subclass of: Clinical or Research Assessment Question
definition: A question about how much difficulty an individual currently has learning new tasks or instructions.
imported from: ncit.owl
code: C137847
Semantic_Type: Intellectual Product
Preferred_Name: Current Difficulty Learning New Tasks or Instructions
UMLS_CUI: C3261567
has exact synonym: Current Difficulty Learning New Tasks or Instructions
has exact synonym: How much DIFFICULTY do you currently have learning new tasks or instructions
in subset: NCIT C137840

Guinea Pig
type: Class
subclass of: Animal Model
definition: The domesticated guinea pig, Cavia porcellus.
imported from: ncit.owl
code: C14211
Semantic_Type: Mammal
Preferred_Name: Guinea Pig
UMLS_CUI: C0999699
Contributing_Source: CDISC
ALT_DEFINITION: The domesticated guinea pig, Cavia porcellus. (NCI)
NCBI_Taxon_ID: 10141
Legacy Concept Name: Guinea_Pig
has exact synonym: CAVIA PORCELLUS
has exact synonym: Cavia porcellus
has exact synonym: GUINEA PIG
has exact synonym: Guinea Pig
has exact synonym: Mammals, Guinea Pigs
in subset: NCIT C160931
in subset: NCIT C61410
in subset: NCIT C77526
in subset: NCIT C77808

Blood Inflammatory Marker
type: Class
subclass of: immune biomarker
definition: A substance detectable in the blood that can be used to assess levels of inflammation in the body.
imported from: ncit.owl
code: C143955
Semantic_Type: Functional Concept
Preferred_Name: Blood Inflammatory Marker
NCI_META_CUI: CL542157
has exact synonym: Blood Inflammatory Marker

Circulating Protein
type: Class
subclass of: Extracellular Protein
definition: Protein found in the peripheral blood.
imported from: ncit.owl
code: C150129
Semantic_Type: Amino Acid, Peptide, or Protein
Display_Name: Circulating Protein
Preferred_Name: Circulating Protein
NCI_META_CUI: CL551923
has exact synonym: Circulating Protein

Clinical Study
type: Class
subclass of: human study
definition: Research conducted with human subjects or on material of human origin in which an investigator directly interacts with human subjects; includes development of new technologies, study of mechanisms of human diseases, therapy, clinical trials, epidemiologic, behavior, and health services research.
imported from: ncit.owl
code: C15206
Semantic_Type: Research Activity
Preferred_Name: Clinical Study
UMLS_CUI: C0008972
Contributing_Source: CDISC
Contributing_Source: CDISC-GLOSS
Contributing_Source: FDA
Contributing_Source: ICDC
ALT_DEFINITION: A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. [ClinicalTrials.gov] See also clinical trial.
ALT_DEFINITION: A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. [ClinicalTrials.gov] See also clinical trial. (CDISC Glossary)
Legacy Concept Name: Clinical_Study
has exact synonym: CLINICAL STUDY
has exact synonym: Clinical Research
has exact synonym: Clinical Studies
has exact synonym: Clinical Study
has exact synonym: Study
has exact synonym: clinical study
has exact synonym: study
in subset: NCIT C132298
in subset: NCIT C132310
in subset: NCIT C165451
in subset: NCIT C175518
in subset: NCIT C54447
in subset: NCIT C54587
in subset: NCIT C61410
in subset: NCIT C67497

Immunotherapy
type: Class
subclass of: therapeutic procedure
definition: Therapy designed to induce changes in a patient's immune status in order to treat disease.
imported from: ncit.owl
Is_PCDC_AML_Permissible_Value_For_Variable: NCIT C173260
code: C15262
Semantic_Type: Therapeutic or Preventive Procedure
Display_Name: Immunotherapy
Preferred_Name: Immunotherapy
UMLS_CUI: C0021083
Contributing_Source: CDISC
Contributing_Source: CPTAC
Contributing_Source: CTRP
Contributing_Source: GDC
Contributing_Source: PCDC
ALT_DEFINITION: A therapy designed to induce changes in a patient's immune status.
ALT_DEFINITION: Treatment to boost or restore the ability of the immune system to fight cancer, infections, and other diseases. Also used to lessen certain side effects that may be caused by some cancer treatments. Agents used in immunotherapy include monoclonal antibodies, growth factors, and vaccines. These agents may also have a direct antitumor effect.
Legacy Concept Name: Immunotherapy
Maps_To: Immunotherapy (Including Vaccines)
DesignNote: The concept encompasses various treatment modalities including active and passive immunization, treatment with immunopotentiators, immunosuppressants and nonspecific systemic immunostimulators and adjuvants, desensitization to any allergens, bone marrow transplantation, thymus implantation.
has exact synonym: IMMUNOTHERAPY
has exact synonym: Immunological
has exact synonym: Immunological Therapy
has exact synonym: Immunologically Directed Therapy
has exact synonym: Immunotherapy
has exact synonym: immunotherapy
in subset: NCIT C101858
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C156954
in subset: NCIT C156955
in subset: NCIT C157711
in subset: NCIT C158037
in subset: NCIT C158520
in subset: NCIT C159125
in subset: NCIT C159328
in subset: NCIT C168549
in subset: NCIT C173231
in subset: NCIT C174019
in subset: NCIT C61410
in subset: NCIT C66830

Longitudinal Study
type: Class
subclass of: Clinical Study
definition: A study in which participants with no known disease are initially assessed, and then reassessed for the same characteristic at mutiple timepoints in the future.
imported from: ncit.owl
code: C15273
Semantic_Type: Research Activity
Preferred_Name: Longitudinal Study
UMLS_CUI: C0023981
Contributing_Source: CDISC
Contributing_Source: CDISC-GLOSS
ALT_DEFINITION: In medicine, a study or clinical trial in which participants are identified and then followed forward in time.
ALT_DEFINITION: Investigation in which data are collected from a number of subjects over a long period of time (a well-known example is the Framingham study).
ALT_DEFINITION: Studies that look forward using periodic observations collected predominantly following subject enrollment. (clinicaltrials.gov)
Legacy Concept Name: Longitudinal_Study
has exact synonym: Longitudinal Study
has exact synonym: PROSPECTIVE
has exact synonym: longitudinal study
has exact synonym: prospective
in subset: NCIT C127261
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C67497

Lumbar Puncture
type: Class
subclass of: specimen collection
definition: An invasive procedure in which a hollow needle is introduced through an intervertebral space in the lower back to access the subarachnoid space in order to sample cerebrospinal fluid or to administer medication.
imported from: ncit.owl
code: C15327
Semantic_Type: Diagnostic Procedure
Preferred_Name: Lumbar Puncture
UMLS_CUI: C0037943
ALT_DEFINITION: A procedure in which a thin needle called a spinal needle is put into the lower part of the spinal column to collect cerebrospinal fluid or to give drugs.
Legacy Concept Name: Lumbar_Puncture
has exact synonym: LP
has exact synonym: Lumbar Puncture
has exact synonym: Spinal Tap
has exact synonym: lumbar puncture
has exact synonym: spinal tap

Case Study
type: Class
subclass of: human study
definition: An uncontrolled observational study containing a detailed report of the diagnosis, treatment, and follow-up of an individual patient. Case reports also contain some demographic information about the patient (for example, age, gender, ethnic origin).
imported from: ncit.owl
code: C15362
Semantic_Type: Research Activity
Preferred_Name: Case Study
UMLS_CUI: C0085973
Contributing_Source: CDISC
ALT_DEFINITION: A detailed report of the diagnosis, treatment, and follow-up of an individual patient. Case reports also contain some demographic information about the patient (for example, age, gender, ethnic origin).
ALT_DEFINITION: A study in which the subject with the condition under study (the case) is compared against a theoretical/historical model of distribution that serves as a control.
Legacy Concept Name: Case_Study
has exact synonym: CASE ONLY
has exact synonym: Case Report
has exact synonym: Case Study
has exact synonym: case report
in subset: NCIT C127259
in subset: NCIT C132298
in subset: NCIT C61410
in subset: NCIT C66830

Cognition Clock Test
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A test of the ability of an individual to accurately place the numbers and hands of a clock in their usual and specified positions.
imported from: ncit.owl
code: C157012
Semantic_Type: Intellectual Product
Preferred_Name: Cognition Clock Test
NCI_META_CUI: CL936069
has exact synonym: Cognition Clock Test
in subset: NCIT C157011

Genetic Testing
type: Class
subclass of: assay
definition: The process of isolating and testing the DNA of an embryo or a person to detect the presence of genetic alterations or defects that may predispose to the future development of a disease or disorder.
imported from: ncit.owl
code: C15709
Semantic_Type: Laboratory Procedure
Display_Name: Genetic Testing
Preferred_Name: Genetic Testing
UMLS_CUI: C0679560
Contributing_Source: CTRP
Contributing_Source: NICHD
ALT_DEFINITION: Analyzing DNA to look for a genetic alteration that may indicate an increased risk for developing a specific disease or disorder.
Legacy Concept Name: Genetic_Testing
NICHD_Hierarchy_Term: Genetic Testing
has exact synonym: Genetic Examination
has exact synonym: Genetic Test
has exact synonym: Genetic Testing
has exact synonym: genetic analysis
has exact synonym: genetic testing
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C89506
in subset: NCIT C90259
in subset: NCIT C99147

Surveillance
type: Class
subclass of: epidemiological study
definition: The systematic collection, analysis, and interpretation of health data on an ongoing basis.
imported from: ncit.owl
code: C15719
Semantic_Type: Health Care Activity
Preferred_Name: Surveillance
NCI_META_CUI: CL426379
ALT_DEFINITION: In medicine, the ongoing collection of information about a disease, such as cancer, in a certain group of people. The information collected may include where the disease occurs in a population and whether it affects people of a certain gender, age, or ethnic group.
Legacy Concept Name: Surveillance
has exact synonym: Epidemiology / Surveillance
has exact synonym: Surveillance
has exact synonym: surveillance

Executive Function Disorder
type: Class
subclass of: cognitive disorder
definition: Cognitive, emotional, and behavioral difficulties that often occur in conjunction with frontal lobe disorders, including traumatic injury and dementia. It is also a feature of attention deficit disorder and other non-trauma-induced conditions.
imported from: ncit.owl
code: C160587
Semantic_Type: Mental or Behavioral Dysfunction
Display_Name: Executive Function Disorder
Preferred_Name: Executive Function Disorder
Contributing_Source: CTRP
has exact synonym: EFD
has exact synonym: Executive Dysfunction
has exact synonym: Executive Function Disorder
has exact synonym: Executive Functioning Deficit
has exact synonym: Impairment of Executive Functions
in subset: NCIT C116977
in subset: NCIT C118168

Chromogranin
type: Class
subclass of: Peptide Hormone
definition: Chromogranins are acidic secretory glycoproteins with a widespread but specific distribution in neuroendocrine tissues. The chromogranin family is heterogenous, consisting of propeptides such as chromogranin-A, chromogranin-B and secretogranin II, which can either elicit an effect themselves, or serve as precursors to a large number of peptides, which are biologically more active.
imported from: ncit.owl
code: C16436
Semantic_Type: Amino Acid, Peptide, or Protein
Preferred_Name: Chromogranin
UMLS_CUI: C0008586
Legacy Concept Name: Chromogranin
has exact synonym: CHG
has exact synonym: Chromogranin

Diagnostic Imaging
type: Class
subclass of: imaging technique
definition: Any method that uses a visual display of structural or functional patterns of organs or tissues for diagnostic evaluation.
imported from: ncit.owl
code: C16502
Semantic_Type: Diagnostic Procedure
Display_Name: Diagnostic Imaging
Preferred_Name: Diagnostic Imaging
UMLS_CUI: C0011923
Contributing_Source: CTRP
Contributing_Source: GDC
Legacy Concept Name: Diagnostic_Imaging
Maps_To: Diagnostic Imaging
has exact synonym: Diagnostic Imaging
has exact synonym: Medical Imaging
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C157711
in subset: NCIT C159074

DNA Binding Protein
type: Class
subclass of: protein
definition: Proteins that non-covalently interact with deoxyribonucleic acid as a result of intermolecular physical forces and spatial complementarity. Many genetic regulatory DNA binding proteins bind to double- or single-stranded DNA in a sequence-specific manner and share common structural motifs such as the zinc-finger, helix-turn-helix, and leucine zipper.
imported from: ncit.owl
code: C16518
Semantic_Type: Amino Acid, Peptide, or Protein
Preferred_Name: DNA Binding Protein
UMLS_CUI: C0012940
Legacy Concept Name: DNA_Binding_Protein
has exact synonym: DNA Binding Protein

Genotype
type: Class
subclass of: quality
definition: The genetic constitution of an organism or cell, as distinct from its expressed features or phenotype.
imported from: ncit.owl
code: C16631
Semantic_Type: Organism Attribute
Preferred_Name: Genotype
UMLS_CUI: C0017431
ALT_DEFINITION: At its broadest level, genotype includes the entire genetic constitution of an individual. It is often applied more narrowly to the set of alleles present at one or more specific loci.
Legacy Concept Name: Genotype
has exact synonym: Genotype
has exact synonym: Genotypic
has exact synonym: genotype

Aducanumab
type: Class
subclass of: Immunotherapy
imported from: ncit.owl
code: C166444
Semantic_Type: Amino Acid, Peptide, or Protein
Preferred_Name: Aducanumab
NCI_META_CUI: CL971693
FDA_UNII_Code: 105J35OE21
Contributing_Source: FDA
has exact synonym: ADUCANUMAB
has exact synonym: Aducanumab
in subset: NCIT C63923

Heat Shock Protein
type: Class
subclass of: Protein Family
definition: A family of highly-conserved proteins that are synthesized in response to hyperthermia (heat shock), hypoxia, or other stresses that appear to increase cellular thermal tolerance and enable cells to recover from stress. Some heat shock proteins may protect other proteins from denaturation, degradation or perform functions essential to cell survival under these conditions.
imported from: ncit.owl
code: C16672
Semantic_Type: Amino Acid, Peptide, or Protein
Preferred_Name: Heat Shock Protein
UMLS_CUI: C0018850
ALT_DEFINITION: One of a group of proteins that help protect cells from stresses such as heat, cold, and low amounts of oxygen or glucose (sugar). Heat-shock proteins help other proteins function in normal cells and may be present at high levels in cancer cells. Blocking the activity of a heat-shock protein called HSP90 is being studied in the treatment of cancer. Other heat-shock proteins including HSP70 and gp96 are being studied in vaccines to treat cancer.
Legacy Concept Name: Heat_Shock_Protein
has exact synonym: HSP
has exact synonym: Heat Shock Protein
has exact synonym: Heat Shock Proteins
has exact synonym: heat-shock protein
has exact synonym: stress protein

Lifestyle
type: Class
subclass of: behavior
definition: A manner of living that reflects the person's values and attitudes.
imported from: ncit.owl
code: C16795
Semantic_Type: Social Behavior
Preferred_Name: Lifestyle
UMLS_CUI: C0023676
Legacy Concept Name: Lifestyle
has exact synonym: Lifestyle

Magnetic Resonance Imaging
type: Class
subclass of: measurement method
subclass of: Diagnostic Imaging
definition: Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders.
imported from: ncit.owl
Is_PCDC_EWS_Permissible_Value_For_Variable: NCIT C117438
code: C16809
Semantic_Type: Diagnostic Procedure
Display_Name: Magnetic Resonance Imaging
Preferred_Name: Magnetic Resonance Imaging
UMLS_CUI: C0024485
Contributing_Source: CDISC
Contributing_Source: CTRP
Contributing_Source: FDA
Contributing_Source: GDC
Contributing_Source: PCDC
ALT_DEFINITION: A procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. These pictures can show the difference between normal and diseased tissue. NMRI makes better images of organs and soft tissue than other scanning techniques, such as computed tomography (CT) or x-ray. NMRI is especially useful for imaging the brain, the spine, the soft tissue of joints, and the inside of bones.
ALT_DEFINITION: Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide amazingly clear and detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders.
Legacy Concept Name: Magnetic_Resonance_Imaging
Maps_To: MRI
has exact synonym: MR Imaging
has exact synonym: MRI
has exact synonym: MRI Scan
has exact synonym: Magnetic Resonance Imaging
has exact synonym: Magnetic Resonance Imaging Scan
has exact synonym: Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance
has exact synonym: NMR Imaging
has exact synonym: NMRI
has exact synonym: Nuclear Magnetic Resonance Imaging
has exact synonym: magnetic resonance imaging
has exact synonym: nuclear magnetic resonance imaging
in subset: NCIT C101858
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C157711
in subset: NCIT C171122
in subset: NCIT C174238
in subset: NCIT C174261
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C85492

Magnetoencephalography
type: Class
subclass of: imaging technique
definition: The measurement of the magnetic fields produced by electrical activity in the brain, usually conducted externally, using extremely sensitive devices. The measurement of electric fields in the brain provides information about the localization of brain activity which is complementary to that provided by electroencephalography.
imported from: ncit.owl
code: C16811
Semantic_Type: Diagnostic Procedure
Display_Name: Magnetoencephalography
Preferred_Name: Magnetoencephalography
UMLS_CUI: C0024489
Contributing_Source: CTRP
Legacy Concept Name: Magnetoencephalography
has exact synonym: MEG
has exact synonym: Magnetoencephalography
in subset: NCIT C116977
in subset: NCIT C118169

Microtubule Associated Protein
type: Class
subclass of: protein
definition: Proteins associated with the microtubule assembly infrastructure. These proteins include specialized motor proteins (dynein and kinesin) and smaller tubulin-crosslinking proteins (tau proteins). The proteins are required for both microtubule assembly and stabilization.
imported from: ncit.owl
code: C16861
Semantic_Type: Amino Acid, Peptide, or Protein
Preferred_Name: Microtubule Associated Protein
UMLS_CUI: C0026045
Legacy Concept Name: Microtubule_Associated_Protein
has exact synonym: MAP
has exact synonym: MAPs
has exact synonym: Microtubule Associated Protein
has exact synonym: Microtubule-Associated Protein
has exact synonym: Microtubule-Associated Proteins

Model
type: Class
subclass of: information content entity
definition: A representation of something, often idealized or modified to make it conceptually easier to understand.
imported from: ncit.owl
code: C16866
Semantic_Type: Intellectual Product
Preferred_Name: Model
UMLS_CUI: C3161035
Contributing_Source: CDISC-GLOSS
ALT_DEFINITION: A formal structure for representing and analyzing a process such as a clinical trial or the information pertaining to a restricted context (e.g., clinical trial data). [CDISC]
Legacy Concept Name: Model_System
has exact synonym: Model
has exact synonym: Model System
has exact synonym: Modeling System
has exact synonym: Models
has exact synonym: model
in subset: NCIT C61410
in subset: NCIT C67497

Computed Tomography
type: Class
subclass of: Diagnostic Imaging
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A method of examining structures within the body by scanning them with X rays and using a computer to construct a series of cross-sectional scans along a single axis.
imported from: ncit.owl
Is_PCDC_EWS_Permissible_Value_For_Variable: NCIT C117438
code: C17204
Semantic_Type: Diagnostic Procedure
Display_Name: Computed Tomography
Preferred_Name: Computed Tomography
UMLS_CUI: C0040405
Contributing_Source: CDISC
Contributing_Source: CTRP
Contributing_Source: FDA
Contributing_Source: GDC
Contributing_Source: PCDC
ALT_DEFINITION: A series of detailed pictures of areas inside the body; the pictures are created by a computer linked to an x-ray machine.
ALT_DEFINITION: An imaging technique for examining structures within the body by scanning them with X rays and using a computer to construct a series of cross-sectional scans along a single axis.
Legacy Concept Name: Computed_Tomography
Maps_To: CT Scan
has exact synonym: CAT
has exact synonym: CAT Scan
has exact synonym: CAT scan
has exact synonym: CT
has exact synonym: CT SCAN
has exact synonym: CT Scan
has exact synonym: CT scan
has exact synonym: Computed Tomography
has exact synonym: Computerized Axial Tomography
has exact synonym: Computerized Tomography
has exact synonym: computed tomography
has exact synonym: computerized axial tomography
has exact synonym: computerized tomography
has exact synonym: tomography
in subset: NCIT C101858
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C157711
in subset: NCIT C171122
in subset: NCIT C174238
in subset: NCIT C174261
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C85492

Study Arm
type: Class
subclass of: study design
definition: A planned pathway assigned to the subject as they progress through the study, usually referred to by a name that reflects one or more treatments, exposures, and/or controls included in the path.
imported from: ncit.owl
code: C174447
Semantic_Type: Research Activity
Preferred_Name: Study Arm
UMLS_CUI: C1522541
Contributing_Source: CDISC
ALT_DEFINITION: A planned pathway assigned to the subject as they progress through the study, usually referred to by a name that reflects one or more treatments, exposures, and/or controls included in the path.
Legacy Concept Name: Protocol_Treatment_Arm
has exact synonym: Arm
has exact synonym: Study Arm
in subset: NCIT C132298
in subset: NCIT C132310
in subset: NCIT C61410

Experimental Model
type: Class
subclass of: Biological Model
imported from: ncit.owl
code: C17456
Semantic_Type: Intellectual Product
Preferred_Name: Experimental Model
UMLS_CUI: C0086272
Legacy Concept Name: Experimental_Model
has exact synonym: Experimental Model
has exact synonym: Experimental Models, Other

Peptide Hormone
type: Class
subclass of: protein
definition: Small proteins that function as hormonal signals, synthesized and secreted by one tissue or organ with physiological effects on other tissues or organs.
imported from: ncit.owl
code: C1746
Semantic_Type: Amino Acid, Peptide, or Protein
Semantic_Type: Hormone
Preferred_Name: Peptide Hormone
UMLS_CUI: C0597192
Legacy Concept Name: Peptide_Hormone
CHEBI_ID: CHEBI:25905
has exact synonym: Peptide Hormone

CCAAT Enhancer Binding Protein
type: Class
subclass of: DNA Binding Protein
definition: A protein which binds to enhancers having a conserved CCAAT sequence. CCAAT enhancer binding proteins are a subclass of bZIP transcription factors that bind the CCAAT DNA sequence as homo- or heterodimers with other family members, C/EBP-alpha, beta, gamma, delta, epsilon. They include both transcriptional activators and repressors, and some are involved in myelopoiesis.
imported from: ncit.owl
code: C17486
Semantic_Type: Amino Acid, Peptide, or Protein
Semantic_Type: Biologically Active Substance
Preferred_Name: CCAAT Enhancer Binding Protein
UMLS_CUI: C0108685
Legacy Concept Name: CCAAT_Enhancer_Binding_Protein
has exact synonym: C/EBP
has exact synonym: CCAAT Enhancer Binding Protein

Study Phase
type: Class
subclass of: study design
definition: A stage in the sequence of activities in a clinical study.
imported from: ncit.owl
code: C176261
Semantic_Type: Temporal Concept
Preferred_Name: Study Phase
Contributing_Source: CDISC-GLOSS
ALT_DEFINITION: A stage in the sequence of activities in a clinical study (e.g., Screening, Randomization, Treatment, Follow-up). See also arm, visit, phase (of clinical development), epoch.
has exact synonym: Study Phase
has exact synonym: phase (within a study)
in subset: NCIT C61410
in subset: NCIT C67497

Phosphorylated Tau Protein to Amyloid Beta1-42 Ratio Measurement
type: Class
subclass of: measurement method
definition: The determination of the ratio of phosphorylated Tau protein compared to amyloid beta 1-42 present in a sample. The measurement may be expressed as a ratio or percentage.
imported from: ncit.owl
code: C176312
Semantic_Type: Laboratory Procedure
Preferred_Name: Phosphorylated Tau Protein to Amyloid Beta1-42 Ratio Measurement
Contributing_Source: CDISC
ALT_DEFINITION: A relative measurement (ratio) of the phosphorylated Tau protein to amyloid beta 1-42 in a biological specimen.
has exact synonym: PTAUAB42
has exact synonym: Phosphorylated Tau Prot/Amyloid Beta1-42
has exact synonym: Phosphorylated Tau Protein to Amyloid Beta1-42 Ratio Measurement
has exact synonym: Phosphorylated Tau Protein/Amyloid Beta 1-42
in subset: NCIT C61410
in subset: NCIT C65047
in subset: NCIT C66830
in subset: NCIT C67154
in subset: NCIT C77526

Subcellular Process
type: Class
subclass of: biological_process
definition: An intracellular or extracellular function, activity, or process principally involving intracellular or extracellular components.
imported from: ncit.owl
code: C17710
Semantic_Type: Phenomenon or Process
Preferred_Name: Subcellular Process
UMLS_CUI: C0230625
Legacy Concept Name: Subcellular_Process
has exact synonym: Cell Process
has exact synonym: Subcellular Process

Heat Shock Protein 70
type: Class
subclass of: Heat Shock Protein
definition: A family of structurally related proteins that are involved in both protein folding and cellular stress responses. The members of this family are approximately 70 kDa.
imported from: ncit.owl
code: C17765
Semantic_Type: Amino Acid, Peptide, or Protein
Display_Name: Heat Shock Protein 70
Preferred_Name: Heat Shock Protein 70
UMLS_CUI: C0243043
Contributing_Source: CTRP
Legacy Concept Name: Heat_Shock_Protein-70
has exact synonym: 70-kD Heat Shock Protein
has exact synonym: 70-kD Heat-Shock Protein
has exact synonym: 70-kDa Heat Shock Protein
has exact synonym: HSP 70
has exact synonym: HSP-70
has exact synonym: HSP70
has exact synonym: HSPA
has exact synonym: Heat Shock Protein 70
has exact synonym: Heat Shock Protein Family A
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

Functional Magnetic Resonance Imaging
type: Class
subclass of: Functional Imaging
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: The principle of functional MRI imaging is to take a series of images of an organ in quick succession and to statistically analyze the images for differences among them. Most commonly used in studies of brain function.
imported from: ncit.owl
code: C17958
Semantic_Type: Diagnostic Procedure
Display_Name: Functional Magnetic Resonance Imaging
Preferred_Name: Functional Magnetic Resonance Imaging
UMLS_CUI: C0376335
Contributing_Source: CDISC
Contributing_Source: CTRP
ALT_DEFINITION: A noninvasive tool used to observe functioning in the brain or other organs by detecting changes in chemical composition, blood flow, or both.
ALT_DEFINITION: A type of MRI that takes a series of images of an organ in quick succession and statistically analyzes the differences between the images.
Legacy Concept Name: Functional_Magnetic_Resonance_Imaging
has exact synonym: FUNCTIONAL MRI
has exact synonym: Functional MRI
has exact synonym: Functional Magnetic Resonance Imaging
has exact synonym: fMRI
has exact synonym: functional magnetic resonance imaging
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C85492

Protein Synthesis
type: Class
subclass of: Subcellular Process
definition: Protein synthesis is the group of processes that are involved in generation of mature protein molecules. Although protein synthesis may involve translation alone in many cases, in others, it involves also protein folding, integration of prosthetic groups, glycosylation, methylation, phosphorylation, lipidation and any other process that may be involved in maturation of the polypeptide to the biologically active form.
imported from: ncit.owl
code: C18103
Semantic_Type: Molecular Function
Preferred_Name: Protein Synthesis
UMLS_CUI: C0597295
Legacy Concept Name: Protein_Synthesis
has exact synonym: Protein Synthesis

Caspase
type: Class
subclass of: enzyme
definition: Caspases are a family of intracellular cysteine proteinases involved in inflammation and apoptosis. These enzymes appear to be involved in the initial signaling events, as well as the downstream proteolytic cleavages, that result in apoptotic cell death. They are specific for aspartic acid at the P1 position and are divided into two classes based on the lengths of their N-terminal pro-domains. Caspases-1, -2, -4, -5, -8, and -10 have long pro-domains; caspases-3, -6, -7, and -9 have short pro-domains. (from Science 1998. 281:1312 and Br Med Bull 1997. 53:478)
imported from: ncit.owl
code: C18153
Semantic_Type: Amino Acid, Peptide, or Protein
Semantic_Type: Enzyme
Display_Name: Caspase
Preferred_Name: Caspase
UMLS_CUI: C0010656
Contributing_Source: CTRP
Legacy Concept Name: Caspase
has exact synonym: Caspase
has exact synonym: Caspases
has exact synonym: Cell-Death Protease
has exact synonym: Cysteine-Dependent Aspartate-Directed Protease
has exact synonym: Cysteine-aspartic Protease
has exact synonym: ICE-like protease
has exact synonym: ICE-like proteases
has exact synonym: Peptidase Family C14
has exact synonym: TNF Alpha ICE Proteinases
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

Metabolic Marker
type: Class
subclass of: biomarker
definition: Specific metabolic changes that characterize an organism's state of health or disease, or response to a particular therapeutic intervention, and helps make diagnosis more accurate or enable physicians to make diagnosis before symptoms appear and to track disease progression.
imported from: ncit.owl
code: C18520
Semantic_Type: Functional Concept
Preferred_Name: Metabolic Marker
UMLS_CUI: C1513159
Legacy Concept Name: Metabolic_Marker
has exact synonym: Metabolic Marker

In Vitro Model
type: Class
subclass of: Experimental Model
definition: In vitro (Latin for within the glass) refers to the technique of performing a given procedure in a controlled environment outside of a living organism.
imported from: ncit.owl
code: C19146
Semantic_Type: Research Activity
Preferred_Name: In Vitro Model
UMLS_CUI: C1515654
Legacy Concept Name: in_vitro_Model
has exact synonym: In Vitro Model

Axiom
annotated source: In Vitro Model
annotated property: definition
annotated target: In vitro (Latin for within the glass) refers to the technique of performing a given procedure in a controlled environment outside of a living organism.

In Vivo Model
type: Class
subclass of: Experimental Model
definition: In vivo (Latin for “within the living”) refers to experimentation using a whole, living organism as opposed to a partial or dead organism.
imported from: ncit.owl
code: C19148
Semantic_Type: Research Activity
Preferred_Name: In Vivo Model
UMLS_CUI: C1515657
Legacy Concept Name: in_vivo_Model
has exact synonym: In Vivo Model

Axiom
annotated source: In Vivo Model
annotated property: definition
annotated target: In vivo (Latin for “within the living”) refers to experimentation using a whole, living organism as opposed to a partial or dead organism.

Transgenic Model
type: Class
subclass of: Animal Model
definition: A disease in a transgenic animal with pathologic mechanisms sufficiently similar to those of a human disease for the animal disease to serve as a model.
imported from: ncit.owl
code: C19272
Semantic_Type: Experimental Model of Disease
Preferred_Name: Transgenic Model
UMLS_CUI: C1519606
Legacy Concept Name: Transgenic_Model
has exact synonym: Transgenic Model

Personal Attribute
type: Class
subclass of: information content entity
definition: The distinguishing qualities or prominent aspects of an individual person.
imported from: ncit.owl
code: C19332
Semantic_Type: Organism Attribute
Preferred_Name: Personal Attribute
UMLS_CUI: C0681884
Legacy Concept Name: Personal_Attribute
has exact synonym: Personal
has exact synonym: Personal Attribute
has exact synonym: Subject Characteristics

Functional Imaging
type: Class
subclass of: imaging technique
definition: The visualization of physiological, cellular or molecular processes in living tissue in real time as they take place in cells, for example, blood flow, oxygen consumption or glucose metabolism. (Bypass Budget)
imported from: ncit.owl
code: C19609
Semantic_Type: Diagnostic Procedure
Preferred_Name: Functional Imaging
UMLS_CUI: C1517324
Legacy Concept Name: Functional_Imaging
has exact synonym: Functional Imaging
has exact synonym: Physiologic Imaging

Extracellular Protein
type: Class
subclass of: protein
definition: Proteins secreted out of the cell to perform a function in the extracellular medium.
imported from: ncit.owl
code: C20031
Semantic_Type: Amino Acid, Peptide, or Protein
Preferred_Name: Extracellular Protein
UMLS_CUI: C1333498
Legacy Concept Name: Extracellular_Protein
has exact synonym: Extracellular Protein

Angiography
type: Class
subclass of: X-Ray Imaging
definition: The X-ray examination of the blood vessels or chambers of the heart.
imported from: ncit.owl
code: C20080
Semantic_Type: Diagnostic Procedure
Display_Name: Angiography
Preferred_Name: Angiography
NCI_META_CUI: CL378222
Contributing_Source: CDISC
Contributing_Source: CTRP
ALT_DEFINITION: A method used to create an image of blood vessels.
ALT_DEFINITION: A procedure to x-ray blood vessels. The blood vessels can be seen because of an injection of a dye that shows up in the x-ray.
Legacy Concept Name: Angiography
has exact synonym: ANGIOGRAPHY
has exact synonym: Angiography
has exact synonym: angiography
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C119016
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C85492

Protein Family
type: Class
subclass of: protein
definition: Collection of proteins that are evolutionarily related. This is reflected in the structural and functional similarities as well as in the extent of sequence conservation or residue identity. (from SCOP)
imported from: ncit.owl
code: C20130
Semantic_Type: Classification
Preferred_Name: Protein Family
UMLS_CUI: C1335532
Legacy Concept Name: Protein_Family
has exact synonym: Protein Family

Farnesyl Transferase Inhibitor
type: Class
subclass of: enzyme inhibitor
definition: Any substance that inhibits protein farnesyltransferase, an enzyme that catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine. Protein farnesyltransferase is involved in Ras-mediated post-translational modification. Inhibition of protein farnesyltransferase may inhibit the oncogenic activity of Ras.
imported from: ncit.owl
code: C2020
Semantic_Type: Chemical Viewed Functionally
Preferred_Name: Farnesyl Transferase Inhibitor
UMLS_CUI: C1517132
Legacy Concept Name: Farnesyl_Transferase_Inhibitor
CHEBI_ID: CHEBI:64133
has exact synonym: FTI
has exact synonym: Farnesyl Transferase Inhibitor
has exact synonym: Farnesyl Transferase Inhibitors
has exact synonym: Farnesyltransferase Inhibitors
has exact synonym: Protein Farnesyltransferase Inhibitor
has exact synonym: Protein Farnesyltransferase Inhibitors

Neurotrophic Factor
type: Class
subclass of: protein
definition: A family of protein growth factors produced by the nervous system and peripheral target tissues. These proteins are critical for development, growth, regeneration, survival, and differentiation of neurons.
imported from: ncit.owl
code: C20391
Semantic_Type: Amino Acid, Peptide, or Protein
Semantic_Type: Biologically Active Substance
Preferred_Name: Neurotrophic Factor
UMLS_CUI: C0132298
Legacy Concept Name: Neurotrophic_Factor
DesignNote: Neurotrophin signaling is mediated by the Trk family of receptor tyrosine kinases. (IP, N. Y. (1998), The Neurotrophins and Neuropoietic Cytokines: Two Families of Growth Factors Acting on Neural and Hematopoietic Cells. Annals of the New York Academy of Sciences, 840: 97-106. doi: 10.1111/j.1749-6632.1998.tb09553.x)
has exact synonym: Neurotrophic Factor
has exact synonym: Neurotrophin

Growth Factor
type: Class
subclass of: material entity
definition: Growth Factors are extracellular signaling molecules (ligands) involved in control of target cell proliferation, cell survival, and cell differentiation. (NCI)
imported from: ncit.owl
code: C20424
Semantic_Type: Amino Acid, Peptide, or Protein
Display_Name: Growth Factor
Preferred_Name: Growth Factor
UMLS_CUI: C0018284
Contributing_Source: CTRP
ALT_DEFINITION: Substances made by the body that function to regulate cell division and cell survival. Some growth factors are also produced in the laboratory and used in biological therapy.
Legacy Concept Name: Growth_Factor
has exact synonym: Growth Agents
has exact synonym: Growth Factor
has exact synonym: Growth Factors
has exact synonym: Growth Factors, Proteins
has exact synonym: Mitogen
has exact synonym: growth factor
in subset: NCIT C116977
in subset: NCIT C142799
in subset: NCIT C142800

Research or Clinical Assessment Tool
type: Class
subclass of: diagnostic test
definition: Any evaluation or assessment tool used to ascertain a patient's condition or diagnosis.
imported from: ncit.owl
code: C20993
Semantic_Type: Intellectual Product
Preferred_Name: Research or Clinical Assessment Tool
UMLS_CUI: C1516602
Contributing_Source: NICHD
Legacy Concept Name: Clinical_Assessment_Tool
NICHD_Hierarchy_Term: Clinical Assessment Tool
has exact synonym: Clinical Assessment Tool
has exact synonym: Clinical or Research Assessment Tool
has exact synonym: Research or Clinical Assessment Tool
in subset: NCIT C90259

Epigenetic Process
type: Class
subclass of: Subcellular Process
definition: Changes in the regulation of the expression of gene activity without alteration of genetic structure.
imported from: ncit.owl
code: C21051
Semantic_Type: Genetic Function
Display_Name: Epigenetic Process
Preferred_Name: Epigenetic Process
UMLS_CUI: C1516924
Contributing_Source: CTRP
Legacy Concept Name: Epigenetic_Process
has exact synonym: Epigenetic Change
has exact synonym: Epigenetic Mechanism
has exact synonym: Epigenetic Process
has exact synonym: Epigenetics
in subset: NCIT C116977
in subset: NCIT C142799

Sedation
type: Class
subclass of: therapeutic procedure
definition: The process of allaying nervous excitement or the state of being calmed. (Taber's)
imported from: ncit.owl
code: C21097
Semantic_Type: Therapeutic or Preventive Procedure
Preferred_Name: Sedation
UMLS_CUI: C0344106
FDA_Table: Patient Code (Appendix B)
Contributing_Source: FDA
ALT_DEFINITION: Patient required sedation or additional sedation.
Legacy Concept Name: Sedation
database cross reference: IMDRF:F17
has exact synonym: Sedation
in subset: NCIT C171094
in subset: NCIT C62596

Synuclein Family
type: Class
subclass of: Protein Family
definition: Small, soluble Synuclein Family proteins are a group of highly conserved post-transcriptionally modified Alpha, Beta, and Gamma proteins expressed primarily in neural tissue and often localized near synaptic vesicles. Synucleins may inhibit PLD2 and regulate vesicular transport. In the N-terminal portion, synucleins have a conserved repeated 11-residue amphipathic alpha-helical motif similar to the lipid-binding A2 domain of apolipoproteins. Synucleins also contain several repeated variations of a highly conserved KTKEGV domain, also present in rho family proteins. In brain, synucleins may be phosphorylated by Ca2+ calmodulin protein kinase II. Synucleins are overexpressed in breast carcinomas and mutations are associated with neurodegenerative illnesses.
imported from: ncit.owl
code: C21217
Semantic_Type: Amino Acid, Peptide, or Protein
Preferred_Name: Synuclein Family
UMLS_CUI: C1336547
Legacy Concept Name: Synuclein_Family
has exact synonym: Synuclein Family

Complement Component Protein
type: Class
subclass of: Blood Proteins
definition: Any of the serum proteins that interact with antigen antibody complex to produce cytolytic, chemotaxic, anaphylactic, and other effects. (from CSP2000)
imported from: ncit.owl
code: C21523
Semantic_Type: Amino Acid, Peptide, or Protein
Preferred_Name: Complement Component Protein
UMLS_CUI: C0312743
ALT_DEFINITION: One of a group of about 20 proteins that is found in the blood and is important in fighting infections and other diseases.
Legacy Concept Name: Complement_Component_Protein
has exact synonym: Complement Component Protein
has exact synonym: complement protein

Evaluation
type: Class
subclass of: planned process
definition: Systematic, objective appraisal of the significance, effectiveness, and impact of activities or condition according to specified objectives and criteria.
imported from: ncit.owl
code: C25214
Semantic_Type: Activity
Display_Name: Evaluation
Preferred_Name: Evaluation
UMLS_CUI: C0220825
Contributing_Source: CTRP
Contributing_Source: NICHD
Legacy Concept Name: Evaluation
NICHD_Hierarchy_Term: Evaluation Procedure
has exact synonym: Evaluate
has exact synonym: Evaluated
has exact synonym: Evaluation
has exact synonym: Evaluation Procedure
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C90259
in subset: NCIT C99147

Factor
type: Class
subclass of: quality
definition: Anything that contributes causally to a result.
imported from: ncit.owl
code: C25506
Semantic_Type: Functional Concept
Preferred_Name: Factor
UMLS_CUI: C1521761
Legacy Concept Name: Factor
has exact synonym: Determinant
has exact synonym: Factor

Sampling
type: Class
subclass of: material processing
definition: The selection and obtaining of small representative quantities of biological material for the purpose of analysis; also, in biomedical statistics, sampling is the selection and implementation of statistical observations in order to estimate properties of an underlying population; also, in environmental science, the collection of representative specimens analyzed to characterize site conditions.
imported from: ncit.owl
code: C25662
Semantic_Type: Activity
Preferred_Name: Sampling
UMLS_CUI: C0870078
Legacy Concept Name: Sampling
has exact synonym: Sampling

Swelling
type: Class
subclass of: general symptom
definition: Enlargement; expansion in size; sign of inflammation
imported from: ncit.owl
code: C3399
Semantic_Type: Sign or Symptom
Preferred_Name: Swelling
UMLS_CUI: C0038999
FDA_Table: Patient Code (Appendix B)
Contributing_Source: FDA
Legacy Concept Name: Swelling
has exact synonym: Swelling

Head Injury
type: Class
subclass of: disorder
subclass of: Restriction
  on property: isRiskFactorFor
  some values from: Alzheimer's disease
definition: A traumatic injury to the head.
imported from: ncit.owl
code: C34660
Semantic_Type: Finding
Preferred_Name: Head Injury
UMLS_CUI: C0018674
FDA_Table: Patient Code (Appendix B)
Contributing_Source: FDA
Contributing_Source: NICHD
ALT_DEFINITION: A traumatic injury to the head.
Legacy Concept Name: Head_Injury
NICHD_Hierarchy_Term: Head Injury
database cross reference: IMDRF:E1610
has exact synonym: Head Injury
has exact synonym: Injury of Head
in subset: NCIT C54450
in subset: NCIT C62596
in subset: NCIT C90259
in subset: NCIT C99147

X-Ray Imaging
type: Class
subclass of: Diagnostic Imaging
definition: A radiographic procedure using the emission of x-rays to form an image of the structure penetrated by the radiation.
imported from: ncit.owl
Is_PCDC_EWS_Permissible_Value_For_Variable: NCIT C117438
code: C38101
Semantic_Type: Diagnostic Procedure
Display_Name: Radiography
Preferred_Name: X-Ray Imaging
UMLS_CUI: C0043299
Contributing_Source: CDISC
Contributing_Source: CTRP
Contributing_Source: PCDC
ALT_DEFINITION: A radiographic procedure using the emission of x-rays, a type of penetrating energy wave.
Legacy Concept Name: Radiography
has exact synonym: Conventional X-Ray
has exact synonym: Diagnostic Radiology
has exact synonym: Medical Imaging, X-Ray
has exact synonym: Radiography
has exact synonym: Static X-Ray
has exact synonym: X-RAY
has exact synonym: X-Ray
has exact synonym: X-Ray Imaging
has exact synonym: X-ray
in subset: NCIT C101858
in subset: NCIT C116977
in subset: NCIT C118169
in subset: NCIT C174238
in subset: NCIT C174261
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C85492

MAPK Signaling Pathway
type: Class
subclass of: pathway
imported from: ncit.owl
code: C38834
Semantic_Type: Functional Concept
Preferred_Name: MAPK Signaling Pathway
UMLS_CUI: C1518102
KEGG_ID: hsa04010
ALT_DEFINITION: The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Legacy Concept Name: MAPK_Signaling_Pathway
has exact synonym: MAPK Signaling Pathway

Beck Depression Inventory
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A twenty-one question survey completed by a patient, with each answer scored on a scale of 0 to 3, designed to measure presence of depression.
imported from: ncit.owl
code: C40438
Semantic_Type: Intellectual Product
Preferred_Name: Beck Depression Inventory
UMLS_CUI: C0451022
Legacy Concept Name: Beck_Depression_Inventory
has exact synonym: Beck Depression Inventory

Study Subject
type: Class
subclass of: study design
definition: A matter or an individual that is observed, analyzed, examined, investigated, experimented upon, or/and treated in the course of a particular study.
imported from: ncit.owl
code: C41189
Semantic_Type: Functional Concept
Display_Name: Study Subject
Preferred_Name: Study Subject
UMLS_CUI: C0681850
Contributing_Source: BRIDG
Contributing_Source: CDISC
Contributing_Source: CTRP
ALT_DEFINITION: A physical entity which is the primary unit of operational and/or administrative interest in a study. EXAMPLE(S): A person who is registered in a study as a recipient of an investigational product or as a control. Individuals who are being screened for studies. Individuals participating in observational or other studies. A pacemaker, a fuse that can be used in medical devices, a cow, a pen of pigs, or a tissue sample from a tissue bank. OTHER NAME(S): NOTE(S): StudySubjects within a study are all of the same type. An entity registered in a study is not part of another entity registered in the same study.
ALT_DEFINITION: A physical entity which is the primary unit of operational and/or administrative interest in a study. EXAMPLE(S): A person who is registered in a study as a recipient of an investigational product or as a control. Individuals who are being screened for studies. Individuals participating in observational or other studies. A pacemaker, a fuse that can be used in medical devices, a cow, a farm, a pen of pigs, or a tissue sample from a tissue bank. NOTE(S): StudySubjects within a study are all of the same type. An entity registered in a study is not part of another entity registered in the same study.
ALT_DEFINITION: An individual who is observed, analyzed, examined, investigated, experimented upon, or/and treated in the course of a particular study.
Legacy Concept Name: Study_Subject
has exact synonym: STUDY SUBJECT
has exact synonym: Study Participant
has exact synonym: Study Subject
has exact synonym: StudySubject
has exact synonym: Subject
in subset: NCIT C116977
in subset: NCIT C159501
in subset: NCIT C159503
in subset: NCIT C165634
in subset: NCIT C170450
in subset: NCIT C61410
in subset: NCIT C66830
in subset: NCIT C78735

Randomized Controlled Clinical Trial
type: Class
subclass of: Clinical Study
definition: A study in which the participants are assigned by chance to separate groups to evaluate treatments. The study also includes a control group, which is undergoing the same rigors of the study with placebo treatment or standard treatment. The trial can also be controlled by the addition of a test group to ensure there are no factors present to skew the results and by the inclusion of peer-review analysis by appropriate government officials. 2005
imported from: ncit.owl
code: C46079
Semantic_Type: Research Activity
Preferred_Name: Randomized Controlled Clinical Trial
UMLS_CUI: C0206035
Legacy Concept Name: Randomized_Controlled_Clinical_Trial
has exact synonym: Randomized Controlled Clinical Trial

Memory Dysfunction
type: Class
subclass of: cognitive disorder
subclass of: Restriction
  on property: isClinicalMarkerFor
  some values from: Alzheimer's disease
definition: Interference or disruption of memory processes. Memory dysfunction refers to the inability to store and retrieve information. This term encompasses a large number of problems and issues associated with intellectual functioning. 2005
imported from: ncit.owl
code: C46084
Semantic_Type: Mental or Behavioral Dysfunction
Preferred_Name: Memory Dysfunction
UMLS_CUI: C3887551
Legacy Concept Name: Memory_Dysfunction
has exact synonym: Memory Dysfunction

Eicosanoid
type: Class
subclass of: lipid
definition: A class of fatty acids derived from the oxidation of one of three 20-carbon fatty acids: eicosapentaenoic acid (EPA), arachidonic acid (AA), or dihomo-gamma-linolenic acid (DGLA). Eicosanoids act locally as autocrine or paracrine hormones to modulate a wide variety of biological processes.
imported from: ncit.owl
code: C463
Semantic_Type: Biologically Active Substance
Semantic_Type: Organic Chemical
Display_Name: Eicosanoid
Preferred_Name: Eicosanoid
UMLS_CUI: C0013725
Contributing_Source: CTRP
Legacy Concept Name: Eicosanoid
CHEBI_ID: CHEBI:23899
has exact synonym: Eicosanoid
has exact synonym: Eicosanoids
in subset: NCIT C116977
in subset: NCIT C142799

Nested Case-control Study
type: Class
subclass of: Longitudinal Study
definition: A study in which a group or cohort of individuals is followed for a certain length of time or until a specific outcome is reached. Studies of this type incorporate the strengths of both cohort and case-control studies but eliminates a portion of the methodologic challenges inherent in both types of studies.
imported from: ncit.owl
code: C48202
Semantic_Type: Research Activity
Preferred_Name: Nested Case-control Study
UMLS_CUI: C0027775
Legacy Concept Name: Nested_Case-control_Study
has exact synonym: Nested Case-control Study

Screening
type: Class
subclass of: planned process
definition: A systematic examination or assessment.
imported from: ncit.owl
code: C48261
Semantic_Type: Diagnostic Procedure
Display_Name: Screening
Preferred_Name: Screening
UMLS_CUI: C1710032
Contributing_Source: CTRP
Legacy Concept Name: Screening_Generic
has exact synonym: Screening
has exact synonym: Screening Generic
in subset: NCIT C116977
in subset: NCIT C118169

Proportion
type: Class
subclass of: statistical data analysis
definition: A part, fraction, share, or number considered in relation to the whole amount or number.
imported from: ncit.owl
code: C49159
Semantic_Type: Quantitative Concept
Preferred_Name: Proportion
UMLS_CUI: C1709707
Legacy Concept Name: Proportion
has exact synonym: Proportion

Phase IIa Trial
type: Class
subclass of: Clinical Study by Phase
definition: A clinical research protocol generally referred to as a pilot or feasibility trial that aims to prove the concept of the new intervention in question.
imported from: ncit.owl
code: C49686
Semantic_Type: Research Activity
Preferred_Name: Phase IIa Trial
UMLS_CUI: C1706446
Contributing_Source: CDISC
Contributing_Source: CDISC-GLOSS
ALT_DEFINITION: A clinical research protocol generally referred to as a pilot or feasibility trial that aims to prove the concept of the new intervention in question. (NCI)
ALT_DEFINITION: Controlled clinical studies that occur after the completion of Phase 1 studies and the first set of exposure-response studies in patients, and before beginning Phase 2b (i.e., patient dose-ranging trial) and Phase 3 clinical efficacy-safety studies. [FDA draft Guidance for industry end of Phase 2a meetings, 9/08].
Legacy Concept Name: Phase_IIA_Trial
has exact synonym: 2A
has exact synonym: PHASE IIA TRIAL
has exact synonym: Phase IIa Trial
has exact synonym: Trial Phase 2A
has exact synonym: Trial Phase IIA
has exact synonym: phase 2a
in subset: NCIT C132298
in subset: NCIT C61410
in subset: NCIT C66737
in subset: NCIT C66830
in subset: NCIT C67497

Phase IIb Trial
type: Class
subclass of: Clinical Study by Phase
definition: A clinical research protocol generally referred to as a well-controlled and pivotal trial that aims to prove the mechanism of action of the new intervention in question. A pivotal study will generally be well-controlled, randomized, of adequate size, and whenever possible, double-blind.
imported from: ncit.owl
code: C49688
Semantic_Type: Research Activity
Preferred_Name: Phase IIb Trial
UMLS_CUI: C1706096
Contributing_Source: CDISC
ALT_DEFINITION: A clinical research protocol generally referred to as a well-controlled and pivotal trial that aims to prove the mechanism of action of the new intervention in question. A pivotal study will generally be well-controlled, randomized, of adequate size, and whenever possible, double-blind. (NCI)
Legacy Concept Name: Phase_IIB_Trial
has exact synonym: 2B
has exact synonym: PHASE IIB TRIAL
has exact synonym: Phase IIb Trial
has exact synonym: Trial Phase 2B
has exact synonym: Trial Phase IIB
in subset: NCIT C132298
in subset: NCIT C61410
in subset: NCIT C66737
in subset: NCIT C66830

Age-Adjusted Mortality Rate
type: Class
subclass of: mortality rate
definition: The death rate, or proportion of a given population that dies, during a specified time period, statistically modified to eliminate the effect of the various age distributions.
imported from: ncit.owl
code: C53360
Semantic_Type: Quantitative Concept
Preferred_Name: Age-Adjusted Mortality Rate
UMLS_CUI: C1706748
Legacy Concept Name: Age-Adjusted_Mortality_Rate
has exact synonym: Age-Adjusted Mortality Rate

Phase 0 Trial
type: Class
subclass of: Clinical Study by Phase
definition: A clinical trial that uses an investigational agent that is available only in very limited quantities and which has never previously given to humans or for which there is extremely limited human experience. Phase 0 clinical trials are intended to enable researchers to understand the path of the drug in the body and its efficacy. Adverse event reporting in Phase 0 trials is expedited.
imported from: ncit.owl
code: C54721
Semantic_Type: Research Activity
Preferred_Name: Phase 0 Trial
UMLS_CUI: C1882358
Contributing_Source: CDISC
Contributing_Source: CDISC-GLOSS
ALT_DEFINITION: First-in-human trials, in a small number of subjects, that are conducted before Phase 1 trials and are intended to assess new candidate therapeutic and imaging agents. The study agent is administered at a low dose for a limited time, and there is no therapeutic or diagnostic intent. NOTE: FDA Guidance for Industry, Investigators, and Reviewers: Exploratory IND Studies, January 2006 classifies such studies as Phase 1. NOTE: A Phase 0 study might not include any drug delivery but may be an exploration of human material from a study (e.g., tissue samples or biomarker determinations). [Improving the Quality of Cancer Clinical Trials: Workshop summary-Proceedings of the National Cancer Policy Forum Workshop, improving the Quality of Cancer Clinical Trials (Washington, DC, Oct 2007)]
ALT_DEFINITION: First-in-human trials, in a small number of subjects, that are conducted before Phase 1 trials and are intended to assess new candidate therapeutic and imaging agents. The study agent is administered at a low dose for a limited time, and there is no therapeutic or diagnostic intent. NOTE: FDA Guidance for Industry, Investigators, and Reviewers: Exploratory IND Studies, January 2006 classifies such studies as Phase 1. NOTE: A Phase 0 study might not include any drug delivery but may be an exploration of human material from a study (e.g., tissue samples or biomarker determinations). [Improving the Quality of Cancer Clinical Trials: Workshop summary-Proceedings of the National Cancer Policy Forum Workshop, improving the Quality of Cancer Clinical Trials (Washington, DC, Oct 2007)] (CDISC glossary)
Legacy Concept Name: Phase_0_Trial
has exact synonym: 0
has exact synonym: PHASE 0 TRIAL
has exact synonym: Phase 0
has exact synonym: Phase 0 Trial
has exact synonym: Pre-Clinical Trial
has exact synonym: Pre-clinical Trial
has exact synonym: Trial Phase 0
has exact synonym: phase 0
in subset: NCIT C132298
in subset: NCIT C61410
in subset: NCIT C66737
in subset: NCIT C66830
in subset: NCIT C67497

Wide Range Achievement Test, 3rd Edition
type: Class
subclass of: Research or Clinical Assessment Tool
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: Measures basic skills in reading, arithmetic, and spelling. It is a screening test that can be administered to determine if a more comprehensive achievement test is needed.
imported from: ncit.owl
code: C62716
Semantic_Type: Intellectual Product
Preferred_Name: Wide Range Achievement Test, 3rd Edition
UMLS_CUI: C1883557
Legacy Concept Name: Wide_Range_Achievement_Test_3rd_Edition
DesignNote: Wilkinson, S. S., Author (1993); Published by Wide Range, Inc
has exact synonym: WRAT-3
has exact synonym: Wide Range Achievement Test, 3rd Edition
has exact synonym: Wide Range Achievement Test, Revision 3
has exact synonym: Wide Range Achievement Test-3

Attributable Risk
type: Class
subclass of: disposition
definition: Part of a risk that is identified as due to exposure to a defined factor.
imported from: ncit.owl
code: C67360
Semantic_Type: Quantitative Concept
Preferred_Name: Attributable Risk
UMLS_CUI: C0814766
ALT_DEFINITION: Proportion of a disease in exposed individuals that can be attributed to an exposure. In the context of genetic studies, the exposure is the frequency of a specific genetic variant.
Legacy Concept Name: Attributable_Risk
has exact synonym: Attributable Risk
has exact synonym: attributable risk

Clinical Study by Phase
type: Class
subclass of: Clinical Study
imported from: ncit.owl
code: C70820
Semantic_Type: Research Activity
Preferred_Name: Clinical Study by Phase
UMLS_CUI: C2347801
Legacy Concept Name: Clinical_Study_by_Phase
has exact synonym: Clinical Study by Phase

Blinded Clinical Study
type: Class
subclass of: Clinical Study
definition: A clinical study that is designed using a procedure in which one or more parties to the study [subject(s), investigator(s), monitor, or/and data analyst(s)] are kept unaware of the treatment assignment(s).
imported from: ncit.owl
code: C70840
Semantic_Type: Research Activity
Preferred_Name: Blinded Clinical Study
UMLS_CUI: C2347038
Contributing_Source: CDISC-GLOSS
Contributing_Source: GDC
ALT_DEFINITION: A study in which the subject, the investigator, or anyone assessing the outcome is unaware of the treatment assignment(s). NOTE: Blinding is used to reduce the potential for bias. [Modified ICH E6 Glossary] See also blinding/masking, double-blind study, single-blind study, triple-blind study; contrast with open-label or unblinded study.
ALT_DEFINITION: A type of study in which the patients (single-blinded) or the patients and their doctors (double-blinded) do not know which drug or treatment is being given. The opposite of a blinded study is an open label study.
Legacy Concept Name: Blinded_Clinical_Study
Maps_To: Blinded Study, Treatment Unknown
has exact synonym: Blind Clinical Study
has exact synonym: Blinded Clinical Study
has exact synonym: Blinded Clinical Trial
has exact synonym: Masked Clinical Study
has exact synonym: blinded study
in subset: NCIT C157711
in subset: NCIT C159125
in subset: NCIT C61410
in subset: NCIT C67497

Animal Model
type: Class
subclass of: In Vivo Model
definition: An animal that is amenable to experimentation and whose physiological or pathologic mechanisms are sufficiently similar to those of a human for the animal to serve as a model.
imported from: ncit.owl
code: C71164
Semantic_Type: Research Activity
Preferred_Name: Animal Model
UMLS_CUI: C0599779
Legacy Concept Name: Animal_Model_Generic
has exact synonym: Animal Model
has exact synonym: Animal Model, Generic
has exact synonym: Research Model, Animal

Erythrocyte Sedimentation Rate Measurement
type: Class
subclass of: blood chemistry measurement
definition: A quantitative measurement of the distance that red blood cells travel in one hour in a sample of unclotted blood.
imported from: ncit.owl
Is_PCDC_EWS_Permissible_Value_For_Variable: NCIT C117142
code: C74611
Semantic_Type: Laboratory Procedure
Display_Name: Erythrocyte Sedimentation Rate Measurement
Preferred_Name: Erythrocyte Sedimentation Rate Measurement
UMLS_CUI: C1176468
Contributing_Source: ACC/AHA
Contributing_Source: CDISC
Contributing_Source: CPTAC
Contributing_Source: CTRP
Contributing_Source: NICHD
Contributing_Source: PCDC
ALT_DEFINITION: A quantitative measurement of the distance that red blood cells settle in one hour in a sample of unclotted blood. Used in the evaluation of systemic inflammation.
ALT_DEFINITION: A quantitative measurement of the distance that red blood cells travel in 1 hour in a sample of unclotted blood.
ALT_DEFINITION: The distance (e.g. millimeters) that red blood cells settle in unclotted blood over a specified unit of time (e.g. one hour).
ALT_DEFINITION: The distance red blood cells travel in one hour in a sample of blood as they settle to the bottom of a test tube. The sedimentation rate is increased in inflammation, infection, cancer, rheumatic diseases, and diseases of the blood and bone marrow.
Legacy Concept Name: Erythrocyte_Sedimentation_Rate_Measurement
NICHD_Hierarchy_Term: Erythrocyte Sedimentation Rate
has exact synonym: Biernacki Reaction
has exact synonym: ESR
has exact synonym: Erythrocyte Sedimentation Rate
has exact synonym: Erythrocyte Sedimentation Rate Measurement
has exact synonym: Erythrocyte sedimentation rate (ESR)
has exact synonym: Sed Rate
has exact synonym: erythrocyte sedimentation rate
has exact synonym: sedimentation rate
in subset: NCIT C116977
in subset: NCIT C118468
in subset: NCIT C142799
in subset: NCIT C156952
in subset: NCIT C156953
in subset: NCIT C159339
in subset: NCIT C159418
in subset: NCIT C167409
in subset: NCIT C174238
in subset: NCIT C174250
in subset: NCIT C61410
in subset: NCIT C65047
in subset: NCIT C66830
in subset: NCIT C67154
in subset: NCIT C77526
in subset: NCIT C90259

Mini-Mental Status Exam
type: Class
subclass of: Clinical or Research Assessment Questionnaire
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A standardized and structured interview originally developed by Marshal Folstein, Susan Folstein and Paul McHugh (Journal of Psychiatric Research, 1975), which is used to evaluate an individual's cognitive function.
imported from: ncit.owl
code: C74982
Semantic_Type: Intellectual Product
Preferred_Name: Mini-Mental Status Exam
UMLS_CUI: C0451306
Contributing_Source: CDISC
ALT_DEFINITION: Mini-Mental State Examination (MMSE) (MMSE Copyright 1975, 1998, 2001 by MiniMental, LLC All rights reserved. Published 2001 by Psychological Assessment Resources, Inc. May not be reproduced in whole or in part in any form or by any means without written permission of Psychological Assessment Resources, Inc.).
Legacy Concept Name: Mini-Mental_Status_Exam
has exact synonym: Folstein Mini-Mental Status Exam
has exact synonym: MMS1
has exact synonym: MMSE
has exact synonym: Mini-Mental State Examination Questionnaire
has exact synonym: Mini-Mental Status Exam
in subset: NCIT C115302
in subset: NCIT C115304
in subset: NCIT C120166
in subset: NCIT C61410
in subset: NCIT C66830

Tramiprosate
type: Class
subclass of: antidementia agent therapy
imported from: ncit.owl
code: C76786
Semantic_Type: Pharmacologic Substance
Preferred_Name: Tramiprosate
UMLS_CUI: C0062961
CAS_Registry: 3687-18-1
FDA_UNII_Code: 5K8EAX0G53
Contributing_Source: FDA
Chemical_Formula: C3H9NO3S
Legacy Concept Name: Tramiprosate
has exact synonym: Alzhemed
has exact synonym: Homotaurine
has exact synonym: TRAMIPROSATE
has exact synonym: Tramiprosate
in subset: NCIT C63923

Latrepirdine
type: Class
subclass of: enzyme inhibitor agent therapy
imported from: ncit.owl
code: C78757
Semantic_Type: Pharmacologic Substance
Preferred_Name: Latrepirdine
UMLS_CUI: C0058188
CAS_Registry: 3613-73-8
Accepted_Therapeutic_Use_For: Alzheimer's disease
FDA_UNII_Code: OD9237K1Z6
Contributing_Source: FDA
Chemical_Formula: C21H25N3
Legacy Concept Name: Dimebolin
has exact synonym: 2,3,4,5-Tetrahydro-2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)ethyl)-1H-pyrido(4,3-b)indole
has exact synonym: Dimebolin
has exact synonym: Dimebon
has exact synonym: LATREPIRDINE
has exact synonym: Latrepirdine
in subset: NCIT C63923

Bapineuzumab
type: Class
subclass of: Immunotherapy
definition: A humanized monoclonal antibody (IgG1) raised against amyloid beta peptides with Alzheimer disease treatment application. Bapineuzumab recognizes and binds the N-terminal amino acids 1-5 of the amyloid beta peptide, and may be used in a passive immunotherapy treatment.
imported from: ncit.owl
code: C79569
Semantic_Type: Amino Acid, Peptide, or Protein
Semantic_Type: Pharmacologic Substance
Preferred_Name: Bapineuzumab
UMLS_CUI: C2698328
CAS_Registry: 648895-38-9
Accepted_Therapeutic_Use_For: Alzheimer's disease
FDA_UNII_Code: NC11WKO35D
Contributing_Source: FDA
Legacy Concept Name: Bapineuzumab
has exact synonym: AAB-001
has exact synonym: Anti-human beta-amyloid Monoclonal Antibody 3D-6
has exact synonym: BAPINEUZUMAB
has exact synonym: Bapineuzumab
has exact synonym: Humanized 3D-6 Monoclonal Antibody
in subset: NCIT C63923

Biological Model
type: Class
subclass of: material entity
subclass of: Restriction
  on property: isModelFor
  some values from: Alzheimer's disease
definition: Systems designed to elucidate facts about complex biological phenomena, usually in a less complex or theoretical test environment.
imported from: ncit.owl
code: C80519
Semantic_Type: Intellectual Product
Preferred_Name: Biological Model
UMLS_CUI: C0026339
Legacy Concept Name: Biological_Model
has exact synonym: Biological Model
has exact synonym: Biological Models
has exact synonym: Model
has exact synonym: Model System

Semagacestat
type: Class
subclass of: enzyme inhibitor agent therapy
imported from: ncit.owl
code: C81115
Semantic_Type: Pharmacologic Substance
Preferred_Name: Semagacestat
UMLS_CUI: C1614973
CAS_Registry: 425386-60-3
FDA_UNII_Code: 3YN0602W4W
Contributing_Source: FDA
Chemical_Formula: C19H27N3O4
Legacy Concept Name: Semagacestat
has exact synonym: LY-450139
has exact synonym: SEMAGACESTAT
has exact synonym: Semagacestat
in subset: NCIT C63923

Beta Amyloid 42 Measurement
type: Class
subclass of: measurement method
definition: The determination of the amount of the 1-42 amino acid beta amyloid protein isoform present in a sample.
imported from: ncit.owl
code: C84809
Semantic_Type: Laboratory Procedure
Preferred_Name: Beta Amyloid 42 Measurement
UMLS_CUI: C2827504
Contributing_Source: CDISC
ALT_DEFINITION: A measurement of amyloid beta protein which is composed of peptides 1 to 42 in a biological specimen.
has exact synonym: AMYLB42
has exact synonym: Amyloid Beta 1-42
has exact synonym: Amyloid Beta 1-42 Measurement
has exact synonym: Amyloid Beta 42
has exact synonym: Amyloid Beta 42 Protein
has exact synonym: Beta Amyloid 1-42 Measurement
has exact synonym: Beta Amyloid 42 Measurement
in subset: NCIT C61410
in subset: NCIT C65047
in subset: NCIT C66830
in subset: NCIT C67154
in subset: NCIT C77526

Tau Protein Measurement
type: Class
subclass of: measurement method
definition: The determination of the amount of Tau protein present in a sample.
imported from: ncit.owl
Related_To_Genetic_Biomarker: NCIT C75635
code: C84810
Semantic_Type: Laboratory Procedure
Preferred_Name: Tau Protein Measurement
UMLS_CUI: C2827505
Contributing_Source: CDISC
ALT_DEFINITION: A measurement of the total Tau protein in a biological specimen.
has exact synonym: TPROT
has exact synonym: Tau Protein
has exact synonym: Tau Protein Measurement
has exact synonym: Total Tau Protein
in subset: NCIT C61410
in subset: NCIT C65047
in subset: NCIT C66830
in subset: NCIT C67154
in subset: NCIT C77526

Phosphorylated Tau Protein Measurement
type: Class
subclass of: measurement method
definition: The determination of the amount of phosphorylated Tau protein present in a sample.
imported from: ncit.owl
Related_To_Genetic_Biomarker: NCIT C75635
code: C84812
Semantic_Type: Laboratory Procedure
Preferred_Name: Phosphorylated Tau Protein Measurement
UMLS_CUI: C2827507
Contributing_Source: CDISC
ALT_DEFINITION: A measurement of the phosphorylated Tau protein in a biological specimen.
has exact synonym: Phosphorylated Tau Protein
has exact synonym: Phosphorylated Tau Protein Measurement
has exact synonym: TPROTP
in subset: NCIT C61410
in subset: NCIT C65047
in subset: NCIT C66830
in subset: NCIT C67154
in subset: NCIT C77526

NINCDS-ADRDA Criteria for Alzheimer's Disease
type: Class
subclass of: Diagnostic Criteria
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: Criteria for the diagnosis of Alzheimer's disease (AD), proposed in 1984 by the National Institute of Neurological and Communicative Disorders (NINCDS) and the Stroke-Alzheimer's Disease and Related Disorders Association (ADRDA, now the Alzheimer's Association). The criteria state that existing cognitive impairment may be considered possible or probable AD by neuropsychological testing but definitive diagnosis requires histopathologic confirmation. They specify eight cognitive domains that may be impaired in AD: memory, language, perceptual skills, attention, constructive abilities, orientation, problem solving, and functional abilities.
imported from: ncit.owl
code: C86983
Semantic_Type: Idea or Concept
Preferred_Name: NINCDS-ADRDA Criteria for Alzheimer's Disease
UMLS_CUI: C2828081
has exact synonym: NINCDS-ADRDA Criteria for Alzheimer's Disease
has exact synonym: National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association Criteria for Alzheimer's Disease

Executive Function
type: Class
subclass of: mental process
definition: A set of mental processes that controls and manages the cognitive functions.
imported from: ncit.owl
code: C88419
Semantic_Type: Mental Process
Preferred_Name: Executive Function
UMLS_CUI: C0935584
has exact synonym: Executive Function

Clinical or Research Assessment Question
type: Class
subclass of: Research or Clinical Assessment Tool
definition: A question pertaining to a clinical or research assessment.
imported from: ncit.owl
code: C91102
Semantic_Type: Intellectual Product
Preferred_Name: Clinical or Research Assessment Question
UMLS_CUI: C2984039
has exact synonym: Clinical or Research Assessment Question

Clinical or Research Assessment Questionnaire
type: Class
subclass of: Research or Clinical Assessment Tool
definition: An instrument consisting of a predetermined set of questions for a clinical or research assessment.
imported from: ncit.owl
code: C91105
Semantic_Type: Intellectual Product
Preferred_Name: Clinical or Research Assessment Questionnaire
UMLS_CUI: C2984042
has exact synonym: Clinical or Research Assessment Questionnaire

Hazard Ratio
type: Class
subclass of: statistical data analysis
imported from: ncit.owl
code: C93150
Semantic_Type: Quantitative Concept
Preferred_Name: Hazard Ratio
UMLS_CUI: C2985465
ALT_DEFINITION: A measure of how often a particular event happens in one group compared to how often it happens in another group, over time. In cancer research, hazard ratios are often used in clinical trials to measure survival at any point in time in a group of patients who have been given a specific treatment compared to a control group given another treatment or a placebo. A hazard ratio of one means that there is no difference in survival between the two groups. A hazard ratio of greater than one or less than one means that survival was better in one of the groups.
has exact synonym: Hazard Ratio
has exact synonym: hazard ratio

Retrospective Cohort Study
type: Class
subclass of: Clinical Study
imported from: ncit.owl
code: C93228
Semantic_Type: Research Activity
Preferred_Name: Retrospective Cohort Study
UMLS_CUI: C2985505
ALT_DEFINITION: A research study in which the medical records of groups of individuals who are alike in many ways but differ by a certain characteristic (for example, female nurses who smoke and those who do not smoke) are compared for a particular outcome (such as lung cancer).
has exact synonym: Retrospective Cohort Study
has exact synonym: historic cohort study
has exact synonym: retrospective cohort study

Gamma Secretase
type: Class
subclass of: enzyme
definition: A protein complex that plays a role in the intramembrane cleavage of integral proteins such as Notch receptors and amyloid beta A4 protein.
imported from: ncit.owl
code: C95114
Semantic_Type: Amino Acid, Peptide, or Protein
Semantic_Type: Enzyme
Preferred_Name: Gamma Secretase
UMLS_CUI: C0379528
DesignNote: The components required for the enzymatic activity of gamma secretase are a homodimer of presenilin (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. The proteolytic activity appears to be mediated by presenilin, while the other proteins are required for both stabilization of the active form of presenilin and localization of the complex.
has exact synonym: Gamma Secretase
has exact synonym: Gamma-Secretase

Dimerization
type: Class
subclass of: cellular process
definition: A physical interaction between exactly two molecules or subunits to create a lasting compound.
imported from: ncit.owl
code: C97201
Semantic_Type: Molecular Function
Preferred_Name: Dimerization
UMLS_CUI: C0376525
has exact synonym: Dimerization
has exact synonym: Dimerize

Thiazolidinedione Antidiabetic Agent
type: Class
subclass of: pharmacotherapy
definition: Any antidiabetic agent with the glitazone (thiazolidinedione) base structure with antihyperglycemic activity. Glitazone antidiabetic agents selectively bind to and stimulate the nuclear receptor peroxisome proliferator-activated receptor (PPAR) gamma. This results in the selective transcription of a number of insulin-sensitive genes involved in glucose metabolism. This eventually enhances insulin sensitivity, reduces insulin resistance and decreases hepatic gluconeogenesis. PPARs function as transcription factors that regulate expressions of genes involved in cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), as well as tumorigenesis; PPARgamma is expressed at high levels in adipose tissue.
imported from: ncit.owl
code: C98241
Semantic_Type: Chemical Viewed Functionally
Preferred_Name: Thiazolidinedione Antidiabetic Agent
UMLS_CUI: C3273907
Contributing_Source: GDC
Maps_To: Thiazolidinedione
has exact synonym: Thiazolidinedione
has exact synonym: Thiazolidinedione Antidiabetic Agent
in subset: NCIT C157711
in subset: NCIT C159026

Primary Outcome Measure
type: Class
subclass of: clinical measurement
definition: The primary measurement(s) or observation(s) used to measure the effect of experimental variables in a study, or for observational studies, to describe patterns of diseases or traits or associations with exposures, risk factors or treatment. These are the outcome measures used to assess the primary objective(s).
imported from: ncit.owl
code: C98772
Semantic_Type: Intellectual Product
Preferred_Name: Primary Outcome Measure
UMLS_CUI: C3274433
Contributing_Source: CDISC
ALT_DEFINITION: The outcome measure(s) of greatest importance specified in the protocol, usually the one(s) used in the power calculation, to evaluate the primary endpoint(s) associated with the primary study objective(s). (After Clinicaltrials.gov)
has exact synonym: OUTMSPRI
has exact synonym: PRIMARY OUTCOME MEASURE
has exact synonym: Primary Outcome Measure
in subset: NCIT C117745
in subset: NCIT C132298
in subset: NCIT C170442
in subset: NCIT C61410
in subset: NCIT C66738
in subset: NCIT C66830
in subset: NCIT C67152
in subset: NCIT C81222

Secondary Outcome Measure
type: Class
subclass of: clinical measurement
definition: Other key measures that will be used to evaluate the intervention(s) or, for observational studies, that are a focus of the study. These are the outcome measures used to assess the secondary objective(s).
imported from: ncit.owl
code: C98781
Semantic_Type: Intellectual Product
Preferred_Name: Secondary Outcome Measure
UMLS_CUI: C3274440
Contributing_Source: CDISC
ALT_DEFINITION: The outcome measure(s) that is part of a pre-specified analysis plan used to evaluate the secondary endpoint(s) associated with secondary study objective(s) and/or used to evaluate any measure(s) ancillary to the primary or secondary endpoint(s). (After Clinicaltrials.gov).
has exact synonym: OUTMSSEC
has exact synonym: SECONDARY OUTCOME MEASURE
has exact synonym: Secondary Outcome Measure
in subset: NCIT C117745
in subset: NCIT C132298
in subset: NCIT C170442
in subset: NCIT C61410
in subset: NCIT C66738
in subset: NCIT C66830
in subset: NCIT C67152
in subset: NCIT C81222

adverse event
type: Class
subclass of: pathological bodily process
definition: a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event.
editor note: Melanie Courtot and YH: More work is needed on how to restrict the scope of a term to be an 'adverse event', notably regarding temporal association. When is an appropirate time interval between a medical intervention and an adverse event observed? One week, one month, one year, or a lifetime? For some well-studied medical interventions (e.g., administration of many vaccines or drugs), we probably have a general idea. For many new interventions, we don't know much. In OAE, this issue is associated with defining the 'adverse event incubation time'.
editor note: YH: An adverse event is a process that has specified output of some adverse medical outcome (e.g., symptom, sign or accident) after a medical intervention (or process) (e.g., administration of drug or vaccine). The medical intervention can be an administration of a drug, a vaccine (i.e., vaccination), or a special nutritional product (for example, dietary supplement, infant formula, medical food), surgery, or usage of a medical device.
editor note: YH: An adverse event is possibly induced by the medical intervention. It can be caused by the medical intervention, or may not be caused by the medical intervention. One ultimate goal (or the goal in clinics) of study adverse events is to assess if the adverse event outcome is due to the medical intervention.
editor note: YH: In development of OAE, we initially use vaccine adverse event as our use case. A vaccine adverse event is associated with a vaccination (i.e. a medical intervention), regardless of whether it is considered vaccine-related, and includes any side effect, injury, toxicity, or sensitivity reaction or significant failure of immunization (i.e., a pharmacologic action). Ref: Baylor NW and Midthum K. Regulation and testing of vaccines. In: Vaccines (Editors: Plotkin S, Orenstein W, and Offit P). 2008. p1623.
editor note: YH: The current term 'adverse event' is different from the term definition shown in our paper: He Y, Xiang Z, Sarntivijai S, Toldo L, Ceusters W. OAE: a realism-based biomedical ontology for the representation of adverse events. Adverse Event Representation Workshop, International Conference on Biomedical Ontologies (ICBO), University at Buffalo, NY, July 26-30, 2011. Full lenghth conference proceeding paper. We made the name changing in order to make OAE cover the broader sense of the 'adverse event' which does not assume definite causal effect between an adverse event and a medical intervention. In current definition, the adverse event emphasizes the time association and assumes a likelihood of such a causal association. This term 'adverse event' is stil under the OGMS:pathological bodily process. The 'adverse event' defined in the above paper has now been changed to a new term: 'causal adverse event'. See more information in the new publication: Yongqun He Y, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith. OAE: The Ontology of Adverse Events. Journal of Biomedical Semantics. 2014, 5:29 doi:10.1186/2041-1480-5-29. PMID: 25093068.PMCID: PMC4120740.
editor note: YH: The main scope of OAE includes: (1) represent terms and relations in the area of adverse events, (2) assess possible associations between an adverse event and a medical intervention, particularly, identify any causal effect of a medical intervention to an adverse event; and (2) understand the mechanism (including molecular mechanisms) of causal adverse events.
editor note: YH: There has been discussion regarding whether the term 'side effect' is an alternative term for 'adverse event'. In AERO, the term 'AERO:adverse event' represents a subset of those adverse events for which causality has been established. In OAE, an adverse event for which causality has been established is called 'causal adverse event'.
definition editor: Yongqun He
alternative term: AE
alternative term: adverse reaction
definition source: WEB: http://en.wikipedia.org/wiki/Adverse_event
definition source: WEB: http://www.fda.gov/Safety/MedWatch/HowToReport/ucm053087.htm
definition source: WEB: http://www.ncbi.nlm.nih.gov/pubmed/25093068
imported from: oae.owl
comment: The OAE official website is: http://www.oae-ontology.org/.

medical intervention
type: Class
subclass of: planned process
definition: medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury.
editor note: The act of intervening, interfering or interceding with the intent of modifying the outcome. In medicine, an intervention is usually undertaken to help treat or cure a condition. For example, "Acupuncture as a therapeutic intervention is widely practiced in the United States," Reference: http://www.medterms.com/script/main/art.asp?articlekey=34214 . Some interventions can be used for diagnosis.
definition editor: YH
definition source: WEB: http://wiki.answers.com/Q/What_is_medical_intervention
imported from: oae.owl

adverse drug effect
type: Class
subclass of: disposition
definition: an adverse effect that occurs after a drug administration: an appreciably harmful or unpleasant reaction resulting from an intervention related to the use of a medicinal product
definition editor: YH, SJ
definition source: http://www.ncbi.nlm.nih.gov/pubmed/11072960
imported from: oae.owl
has_MedDRA_id: 10061623

brain AE
type: Class
subclass of: adverse event
definition: an adverse event that occurs in brain.
definition editor: YH
alternative term: brain disorder AE
imported from: oae.owl

synaptic plasticity
type: Class
subclass of: quality
imported from: oba.owl
has_obo_namespace: oba
id: OBA:0000141
comment: http://code.google.com/p/pato/issues/detail

statistical data analysis
type: Class
subclass of: data transformation
definition: a data transformation that has input of mulitple data and report overall trend of the data.
definition editor: Jie Zheng, Oliver He
definition source: WEB: https://en.wikipedia.org/wiki/Statistics
imported from: obcs.owl

measurement scale
type: Class
subclass of: information content entity
definition: An information content entity that represents a type of scale on which a variable is measured, including nominal, ordinal, interval, ratio.
definition editor: Marcy Harris
alternative term: level of measurement
alternative term: scale of measure
definition source: WEB: http://en.wikipedia.org/wiki/Level_of_measurement
imported from: obcs.owl

absolute risk
type: Class
subclass of: derived data from inferential statistical analysis
definition: A data item of an observed or calculated probability of occurrence of an event, X, in a population related to exposure to a specific hazard, infection, trauma; the number of persons suffering from a disease when the exposed population is known with certainty.
definition editor: Yongqun He
definition source: WEB: http://medical-dictionary.thefreedictionary.com/absolute+risk
imported from: obcs.owl

Incidence rate
type: Class
subclass of: rate
definition: A data item that refers to the number of new events that have occurred in a specific time interval divided by the population at risk at the beginning of the time interval. The result gives the likelihood of developing an event in that time interval.
definition editor: Yongqun He
alternative term: incidence
definition source: WEB: http://www.uptodate.com/contents/glossary-of-common-biostatistical-and-epidemiological-terms
imported from: obcs.owl

prevalence rate
type: Class
subclass of: rate
definition: A data item that refers to the number of individuals with a given disease at a given point in time divided by the population at risk at a specified point in time or over a specified period of time.
definition editor: Yongqun He, Jie Zheng
alternative term: prevalence
definition source: WEB: http://health.mo.gov/training/epi/PrevalenceRates.html
definition source: WEB: http://www.uptodate.com/contents/glossary-of-common-biostatistical-and-epidemiological-terms
imported from: obcs.owl

relative risk
type: Class
subclass of: derived data from inferential statistical analysis
definition: A data item that equals the incidence in exposed individuals divided by the incidence in unexposed individuals. The relative risk can be calculated from studies in which the proportion of patients exposed and unexposed to a risk is known, such as a cohort study.
definition editor: Yongqun He
definition source: WEB: http://www.uptodate.com/contents/glossary-of-common-biostatistical-and-epidemiological-terms
imported from: obcs.owl

mann-whitney U test
type: Class
subclass of: statistical data analysis
definition: A non-parametric test of the null hypothesis that two populations are the same against an alternative hypothesis
definition editor: Marcy Harris
alternative term: Wilcoxon rank-sum test
definition source: WEB: http://en.wikipedia.org/wiki/Mann%E2%80%93Whitney_U
imported from: obcs.owl

standardized mortality ratio
type: Class
subclass of: derived data from inferential statistical analysis
definition: A data item which is the ratio of observed deaths in the study group to expected deaths in the general population.
definition editor: Person: Jie Zheng, Oliver He
alternative term: SMR
definition source: http://en.wikipedia.org/wiki/Standardized_mortality_ratio
imported from: obcs.owl

derived data from inferential statistical analysis
type: Class
subclass of: data item
definition: A data item that is derived from an inferential statistical data analysis.
definition editor: Jie Zheng, Yongqun He
alternative term: inferential statistic
definition source: WEB: http://psc.dss.ucdavis.edu/sommerb/sommerdemo/stat_inf/intro.htm
definition source: WEB: http://www.ask.com/question/what-is-numerical-data
imported from: obcs.owl

mortality rate
type: Class
subclass of: rate
definition: A rate of deaths (in general, or due to a specific cause) that in a particular population, scaled to the size of that population, per unit of time.
definition editor: Jie Zheng
definition source: https://en.wikipedia.org/wiki/Mortality_rate
imported from: obcs.owl

planned process
type: Class
subclass of: process
editor preferred label: planned process
example of usage: Injecting mice with a vaccine in order to test its efficacy
has curation status: IAO_0000122
definition: A process that realizes a plan which is the concretization of a plan specification.
definition: A processual entity that realizes a plan which is the concretization of a plan specification.
editor note: 'Plan' includes a future direction sense. That can be problematic if plans are changed during their execution. There are however implicit contingencies for protocols that an agent has in his mind that can be considered part of the plan, even if the agent didn't have them in mind before. Therefore, a planned process can diverge from what the agent would have said the plan was before executing it, by adjusting to problems encountered during execution (e.g. choosing another reagent with equivalent properties, if the originally planned one has run out.)
editor note: We are only considering successfully completed planned processes. A plan may be modified, and details added during execution. For a given planned process, the associated realized plan specification is the one encompassing all changes made during execution. This means that all processes in which an agent acts towards achieving some objectives is a planned process.
definition editor: Bjoern Peters
definition source: branch derived
curator note: 6/11/9: Edited at workshop. Used to include: is initiated by an agent
curator note: This class merges the previously separated objective driven process and planned process, as they the separation proved hard to maintain. (1/22/09, branch call)
imported from: ero.owl
imported from: oae.owl
imported from: obi.owl
imported from: ogms.owl
imported from: vo.owl

drug role
type: Class
subclass of: role
editor preferred label: drug role
example of usage: http://www.answers.com/topic/drug 1. A substance used in the diagnosis, treatment, or prevention of a disease or as a component of a medication. 2. Such a substance as recognized or defined by the U.S. Food, Drug, and Cosmetic Act.
has curation status: IAO_0000120
definition: a role borne by a molecular entity and is realized in a process of absorption by an organism alters, or effects (or is assumed to effect) a function(s) which inhere in an organism
definition editor: Role Branch
alternative term: drug
definition source: OBI, CDISC
imported from: obi.owl

processed material
type: Class
subclass of: material entity
editor preferred label: processed material
example of usage: Examples include gel matrices, filter paper, parafilm and buffer solutions, mass spectrometer, tissue samples
has curation status: IAO_0000122
definition: Is a material entity that is created or changed during material processing.
definition editor: PERSON: Alan Ruttenberg
imported from: obi.owl

assay
type: Class
subclass of: technique
editor preferred label: assay
example of usage: Assay the wavelength of light emitted by excited Neon atoms. Count of geese flying over a house.
has curation status: IAO_0000122
definition: A planned process with the objective to produce information about some evaluant
definition: A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies.
editor note: 12/3/12: BP: the reference to the 'physical examination' is included to point out that a prediction is not an assay, as that does not require physical examiniation.
definition editor: PlanAndPlannedProcess Branch
alternative term: measuring
alternative term: scientific observation
definition source: OBI branch derived
imported from: ero.owl
imported from: obi.owl
ISA alternative term: study assay
IEDB alternative term: any method

material processing
type: Class
subclass of: technique
subclass of: planned process
editor preferred label: material processing
example of usage: A cell lysis, production of a cloning vector, creating a buffer.
has curation status: IAO_0000122
definition: A planned process which results in physical changes in a specified input material
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Frank Gibson
definition editor: PERSON: Jennifer Fostel
definition editor: PERSON: Melanie Courtot
definition editor: PERSON: Philippe Rocca Serra
alternative term: material transformation
definition source: OBI branch derived
imported from: ero.owl
imported from: obi.owl

population
type: Class
subclass of: material entity
editor preferred label: population
example of usage: PMID12564891. Environ Sci Technol. 2003 Jan 15;37(2):223-8. Effects of historic PCB exposures on the reproductive success of the Hudson River striped bass population.
has curation status: IAO_0000125
definition: a population is a collection of individuals from the same taxonomic class living, counted or sampled at a particular site or in a particular area
editor note: 1/28/2013, BP, on the call it was raised that we may want to switch to an external ontology for all populatin terms: http://code.google.com/p/popcomm-ontology/
definition editor: PERSON: Philippe Rocca-Serra
definition source: adapted from Oxford English Dictionnary
curator note: rem1: collection somehow always involve a selection process
imported from: obi.owl

disease stage
type: Class
subclass of: process
definition: a part of an occurrence of a disease process which is associated with position in the normal progression of the disease
imported from: obi.owl
imported from: ogms.owl

specimen collection
type: Class
subclass of: material processing
editor preferred label: specimen creation
has curation status: IAO_0000123
definition: a planned process with the objective of obtaining specimen.
editor note: Note: definition is in specimen creation objective which is defined as an objective to obtain and store a material entity for potential use as an input during an investigation.
definition editor: Bjoern Peters
curator note: 5/31/2012: This process is not necessarily an acquisition, as specimens may be collected from materials already in posession
curator note: 6/9/09: used at workshop
imported from: ero.owl
imported from: obi.owl

statistical hypothesis test
type: Class
subclass of: data transformation
editor preferred label: statistical hypothesis test
has curation status: IAO_0000120
definition: A statistical hypothesis test data transformation is a data transformation that has objective statistical hypothesis test.
definition editor: James Malone
definition source: PERSON: James Malone
imported from: obi.owl

Student's t-test
type: Class
subclass of: statistical hypothesis test
editor preferred label: Student's t-test
has curation status: IAO_0000123
definition: Studen't t-test is a data transformation with the objective of a statistical hypothesis test in which the test statistic has a Student's t distribution if the null hypothesis is true. It is applied when the population is assumed to be normally distributed but the sample sizes are small enough that the statistic on which inference is based is not normally distributed because it relies on an uncertain estimate of standard deviation rather than on a precisely known value.
definition editor: James Malone
definition source: WEB: http://en.wikipedia.org/wiki/T-test
imported from: obi.owl

study intervention
type: Class
subclass of: planned process
editor preferred label: study intervention
has curation status: IAO_0000120
definition: the part of the execution of an intervention design study which is varied between two or more subjects in the study
definition editor: PERSON: Bjoern Peters
definition source: GROUP: OBI
imported from: obi.owl

data transformation
type: Class
subclass of: planned process
editor preferred label: data transformation
example of usage: The application of a clustering protocol to microarray data or the application of a statistical testing method on a primary data set to determine a p-value.
has curation status: IAO_0000122
definition: A planned process that produces output data from input data.
definition editor: Elisabetta Manduchi
definition editor: Helen Parkinson
definition editor: James Malone
definition editor: Melanie Courtot
definition editor: Philippe Rocca-Serra
definition editor: Richard Scheuermann
definition editor: Ryan Brinkman
definition editor: Tina Hernandez-Boussard
alternative term: data analysis
alternative term: data processing
definition source: Branch editors
imported from: obi.owl

chi square test
type: Class
subclass of: statistical hypothesis test
editor preferred label: chi square test
has curation status: IAO_0000123
definition: The chi-square test is a data transformation with the objective of statistical hypothesis testing, in which the sampling distribution of the test statistic is a chi-square distribution when the null hypothesis is true, or any in which this is asymptotically true, meaning that the sampling distribution (if the null hypothesis is true) can be made to approximate a chi-square distribution as closely as desired by making the sample size large enough.
definition editor: PERSON: James Malone
definition editor: PERSON: Tina Boussard
imported from: obi.owl

study design
type: Class
subclass of: information content entity
editor preferred label: study design
example of usage: a matched pairs study design describes criteria by which subjects are identified as pairs which then undergo the same protocols, and the data generated is analyzed by comparing the differences between the paired subjects, which constitute the results of the executed study design.
has curation status: IAO_0000122
definition: A plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution.
editor note: Editor note: there is at least an implicit restriction on the kind of data transformations that can be done based on the measured data available.
definition editor: PERSON: Chris Stoeckert
alternative term: experimental design
curator note: rediscussed at length (MC/JF/BP). 12/9/08). The definition was clarified to differentiate it from protocol.
imported from: obi.owl
imported from: ons.owl
in minimal requirement ONS subset: true

eligibility criterion
type: Class
subclass of: information content entity
editor preferred label: eligibility criterion
example of usage: PMID: 17579629 -Eligibility criteria included: untreated ED-SCLC; age >/=70 and performance status 0-2, or age <70 and PS 3.
has curation status: IAO_0000122
definition: an eligibility criterion (rule) is_a selection criterion which defines and states the requirements (positive or negative) for an entity to be considered as suitable for a given task or participation in a process.
definition editor: Person: Philippe Rocca-Serra
alternative term: eligibility rule
definition source: Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group
imported from: obi.owl

inclusion criterion
type: Class
subclass of: eligibility criterion
editor preferred label: inclusion criterion
example of usage: PMID: 23979341-The major inclusion criterion was patients in whom severe cerebral embolism was diagnosed at age 75 or younger (more than 9 in the NIHSS score on day 7 after the onset of stroke) .
has curation status: IAO_0000125
definition: an inclusion criterion (rule) is_a *eligibility criterion* which defines and states a condition which, if met, makes an entity suitable for a given task or participation in a given process. For instance, in a study protocol, inclusion criteria indicate the conditions that prospective subjects MUST meet to be eligible for participation in a study.
definition editor: Person: Philippe Rocca-Serra
alternative term: inclusion condition
alternative term: inclusion rule
definition source: Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group
imported from: obi.owl

exclusion criterion
type: Class
subclass of: eligibility criterion
editor preferred label: exclusion rule
example of usage: PMID: 17600285-Exclusion criteria included the use of any topical ophthalmic or topical oral medication and/or history of ocular or oral surgery within the past six months.
has curation status: IAO_0000125
definition: an exclusion criterion (rule) is_a *eligibility criterion* which defines and states a condition which, if met, makes an entity unsuitable for a given task or participation in a given process. For instance, in a study protocol, exclusion criteria indicate the conditions that prospective subjects SHOULD NOT meet to be eligible for participation in a study
definition editor: Person: Philippe Rocca-Serra
definition source: Adapted from Clinical Research Glossary Version 4.0 CDICS glossary group
imported from: obi.owl

gene
type: Class
subclass of: material entity
definition: A gene is a material entity that represents the entire DNA sequence required for synthesis of a functional protein or RNA molecule.
definition editor: Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/books/NBK21640/
imported from: ogg.owl

RNA gene
type: Class
subclass of: gene
definition: a gene that encodes for a RNA
definition editor: Oliver He
imported from: ogg.owl

gene of Homo sapiens
type: Class
subclass of: gene
definition: A gene of an organism of Homo sapiens
definition editor: Yue Liu, Bin Zhao, Oliver He
imported from: ogg.owl
organism NCBITaxon ID: 9606

protein-coding gene of Homo sapiens
type: Class
subclass of: gene of Homo sapiens
definition: A gene of Homo sapiens that has a protein-coding gene disposition
definition editor: Bin Zhao, Oliver He
imported from: ogg.owl
organism NCBITaxon ID: 9606

pseudo gene of Homo sapiens
type: Class
subclass of: gene of Homo sapiens
definition: A gene of Homo sapiens that has a pseudo gene disposition
definition editor: Bin Zhao, Oliver He
imported from: ogg.owl
organism NCBITaxon ID: 9606

RNA gene of Homo sapiens
type: Class
subclass of: gene of Homo sapiens
definition: A gene of Homo sapiens that has a RNA gene disposition
definition editor: Bin Zhao, Oliver He
imported from: ogg.owl
organism NCBITaxon ID: 9606

gene of Homo sapiens with unknown gene disposition
type: Class
subclass of: gene of Homo sapiens
definition: A gene of Homo sapiens that has a unknown gene disposition
definition editor: Bin Zhao, Oliver He
imported from: ogg.owl
organism NCBITaxon ID: 9606

A2M
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: A2MD
alternative term: CPAMD5
alternative term: FWP007
alternative term: S863-7
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: A2M
full name from nomenclature authority: alpha-2-macroglobulin
NCBI GeneID: 2
gene map location: 12p13.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001869 (EC: IDA, PMID: 12538697); GO_0002020 (EC: IPI, PMID: 18485748); GO_0002576 (EC: TAS); GO_0004867 (EC: IDA, PMID: 12538697); GO_0005515 (EC: IPI, PMID: 14687906); GO_0005576 (EC: NAS, PMID: 14718574); GO_0005576 (EC: TAS); GO_0005829 (EC: TAS); GO_0007264 (EC: TAS); GO_0007596 (EC: TAS); GO_0007597 (EC: TAS); GO_0010951 (EC: IDA, PMID: 12538697); GO_0019838 (EC: IDA, PMID: 9398211); GO_0019899 (EC: IPI, PMID: 11435418); GO_0019959 (EC: IPI, PMID: 10880251); GO_0019966 (EC: IDA, PMID: 9714181); GO_0022617 (EC: TAS); GO_0030168 (EC: TAS); GO_0030198 (EC: TAS); GO_0031093 (EC: TAS); GO_0043120 (EC: IDA, PMID: 9714181); GO_0048863 (EC: IEA); GO_0051056 (EC: TAS); GO_0070062 (EC: IDA); GO_0072562 (EC: IDA)
has PubMed association: PMID: 59727; 80233; 89758; 1281457; 1370808; 1374237; 1692292; 1697852; 1702714; 1707161; 1724156; 2408344; 2430963; 2459995; 2460294; 2466831; 2467766; 2476070; 2581245; 3289986; 6153632; 6165619; 6167263; 6172288; 6191979; 6195065; 6203908; 6698368; 7519849; 7524416; 7533162; 7533769; 7680268; 7690356; 8583572; 8662763; 9166830; 9344465; 9398211; 9428387; 9714181; 9724081; 9831625; 9865955; 10373500; 10652313; 10681572; 10714547; 10731476; 10880251; 11023837; 11036822; 11058789; 11099722; 11100124; 11121179; 11162584; 11166925; 11231028; 11281447; 11290389; 11435418; 11436125; 11455130; 11484172; 11496365; 11498265; 11811950; 11823454; 11901360; 11910179; 11916201; 11987698; 12015318; 12042276; 12059070; 12062545; 12123860; 12175343; 12194978; 12221172; 12394648; 12477932; 12538697; 12631277; 12754519; 12755614; 12755687; 12782337; 12782964; 12966032; 14506912; 14637088; 14675603; 14678766; 14687906; 14715656; 14718574; 14759632; 14760718; 15023809; 15226301; 15231748; 15468911; 15489334; 15511627; 15611997; 15793779; 15862967; 15908432; 15910735; 15931081; 15950906; 16040006; 16169070; 16232083; 16289162; 16297527; 16335952; 16384981; 16402284; 16407218; 16456795; 16641085; 16650578; 16784755; 16910174; 17071617; 17110338; 17288987; 17403113; 17453620; 17608619; 17967834; 18029348; 18075673; 18077315; 18171086; 18191876; 18382889; 18485748; 18499670; 18579803; 18624398; 18706476; 19074141; 19105203; 19472074; 19639019; 19913121; 20048078; 20085233; 20156641; 20207732; 20301340; 20381197; 20401725; 20493925; 20575108; 20587546; 20628086; 20637261; 20800603; 20861575; 21163940; 21216953; 21541797; 21642630; 21900206; 21971609; 21988832; 22268729; 22541546; 22576683; 22971340; 23064953; 23086799; 23089609; 23186781; 23353684; 23379699; 23397525; 23535567; 23602568; 23643808; 23721263; 23786280; 23846698
description: alpha-2-macroglobulin
database cross reference: Ensembl:ENSG00000175899
database cross reference: HGNC:7
database cross reference: HPRD:00072
database cross reference: MIM:103950
database cross reference: Vega:OTTHUMG00000150267

ABCA1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ABC-1
alternative term: ABC1
alternative term: CERP
alternative term: HDLDT1
alternative term: TGD
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ABCA1
full name from nomenclature authority: ATP-binding cassette, sub-family A (ABC1), member 1
NCBI GeneID: 19
gene map location: 9q31.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002790 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12084722); GO_0005524 (EC: IDA, PMID: 11700048); GO_0005543 (EC: IC, PMID: 16702602); GO_0005548 (EC: IDA, PMID: 16702602); GO_0005794 (EC: IEA); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 10525055); GO_0006497 (EC: IEA); GO_0006911 (EC: IEA); GO_0007040 (EC: IDA, PMID: 15163665); GO_0007186 (EC: IMP, PMID: 16443932); GO_0007584 (EC: IEA); GO_0008203 (EC: IDA, PMID: 14747463); GO_0008509 (EC: ISS); GO_0009986 (EC: IEA); GO_0010745 (EC: TAS, PMID: 18490524); GO_0010875 (EC: IEA); GO_0010887 (EC: TAS, PMID: 18490524); GO_0015485 (EC: IC, PMID: 12084722); GO_0016197 (EC: IDA, PMID: 14747463); GO_0016887 (EC: IEA); GO_0017127 (EC: IDA, PMID: 12084722); GO_0019905 (EC: IPI, PMID: 15469992); GO_0030139 (EC: IDA, PMID: 14747463); GO_0030819 (EC: IMP, PMID: 14701824); GO_0031267 (EC: IPI, PMID: 16443932); GO_0032367 (EC: IMP, PMID: 10431236); GO_0032489 (EC: IMP, PMID: 16443932); GO_0033344 (EC: IDA, PMID: 10431236); GO_0033344 (EC: IMP, PMID: 16443932); GO_0033700 (EC: IDA, PMID: 10431236); GO_0033700 (EC: IMP, PMID: 16702602); GO_0034185 (EC: IPI, PMID: 11162594); GO_0034186 (EC: IPI, PMID: 11162594); GO_0034188 (EC: IDA, PMID: 16443932); GO_0034380 (EC: IMP, PMID: 10431236); GO_0034616 (EC: IEP, PMID: 15358760); GO_0038027 (EC: IDA, PMID: 16443932); GO_0042157 (EC: TAS); GO_0042493 (EC: IEA); GO_0042632 (EC: IDA, PMID: 10431236); GO_0043691 (EC: IMP, PMID: 10431236); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0045121 (EC: IDA, PMID: 15469992); GO_0045332 (EC: IEA); GO_0045335 (EC: IDA, PMID: 15469992); GO_0050702 (EC: IMP, PMID: 11855831); GO_0055091 (EC: IMP, PMID: 16702602); GO_0055098 (EC: IEP, PMID: 15358760); GO_0060155 (EC: IMP, PMID: 15163665); GO_0071222 (EC: IEA); GO_0071300 (EC: IEA); GO_0071397 (EC: IEA)
has PubMed association: PMID: 7766993; 8088782; 9006906; 9731541; 10092505; 10431236; 10431237; 10431238; 10525055; 10533863; 10535983; 10706591; 10799318; 10884428; 10938021; 10970803; 11086027; 11162594; 11238261; 11257260; 11257261; 11279031; 11349008; 11352567; 11476961; 11476965; 11700048; 11719471; 11752403; 11785958; 11809185; 11855831; 11861672; 11864601; 11893753; 11929608; 11940086; 11950847; 12009425; 12032171; 12054535; 12084722; 12093886; 12111371; 12151852; 12176027; 12196520; 12204794; 12226704; 12235128; 12359250; 12426219; 12477932; 12505994; 12509412; 12511593; 12535741; 12551894; 12562845; 12576507; 12600718; 12600975; 12615681; 12624133; 12700893; 12706378; 12709788; 12730295; 12763760; 12804586; 12813037; 12860256; 12869555; 12870173; 12928428; 12952980; 12966036; 14559902; 14560020; 14570867; 14576201; 14644402; 14660648; 14668333; 14681836; 14701812; 14701824; 14701850; 14702039; 14722086; 14734645; 14747463; 14754908; 14767869; 14962947; 14967052; 14967823; 14986172; 14993242; 15024730; 15033469; 15066991; 15102890; 15123239; 15135251; 15140889; 15158913; 15163665; 15201080; 15218032; 15262183; 15280376; 15288432; 15292375; 15297675; 15340333; 15358117; 15358760; 15469992; 15492319; 15500734; 15520867; 15528463; 15528481; 15574409; 15649702; 15657615; 15696473; 15721294; 15774904; 15817453; 15829498; 15851589; 15890646; 15905177; 15930518; 15935359; 15951431; 15952113; 15958302; 15961705; 15983222; 16009332; 16030523; 16055210; 16080812; 16086925; 16118212; 16120575; 16126721; 16157450; 16166555; 16192269; 16192270; 16192271; 16192272; 16192273; 16192274; 16192275; 16192276; 16192277; 16192278; 16192279; 16192281; 16192282; 16192283; 16192284; 16192285; 16192286; 16192287; 16192288; 16192289; 16192290; 16192291; 16192292; 16207713; 16226177; 16235041; 16254209; 16313984; 16343503; 16410457; 16418537; 16429166; 16443932; 16446539; 16456089; 16497665; 16498633; 16500904; 16505586; 16542392; 16596262; 16702602; 16709568; 16725228; 16730733; 16763159; 16770077; 16806233…
description: ATP-binding cassette, sub-family A (ABC1), member 1
database cross reference: Ensembl:ENSG00000165029
database cross reference: HGNC:29
database cross reference: HPRD:02501
database cross reference: MIM:600046
database cross reference: Vega:OTTHUMG00000020417

ACHE
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ACEE
alternative term: ARACHE
alternative term: N-ACHE
alternative term: YT
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ACHE
full name from nomenclature authority: acetylcholinesterase (Yt blood group)
NCBI GeneID: 43
gene map location: 7q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001507 (EC: NAS, PMID: 1517212); GO_0001540 (EC: TAS, PMID: 11283752); GO_0001919 (EC: IEA); GO_0002076 (EC: IEP, PMID: 15454088); GO_0003990 (EC: IDA, PMID: 1517212); GO_0003990 (EC: IMP, PMID: 1517212); GO_0004104 (EC: IDA, PMID: 1517212); GO_0005515 (EC: IPI, PMID: 10800960); GO_0005518 (EC: IDA, PMID: 12524166); GO_0005576 (EC: IDA, PMID: 1517212); GO_0005576 (EC: TAS, PMID: 11283752); GO_0005605 (EC: NAS, PMID: 16289501); GO_0005615 (EC: IBA); GO_0005634 (EC: IEA); GO_0005788 (EC: IBA); GO_0005794 (EC: IDA, PMID: 15454088); GO_0005886 (EC: TAS); GO_0006260 (EC: TAS, PMID: 11283752); GO_0006581 (EC: IDA, PMID: 1517212); GO_0006644 (EC: TAS); GO_0006656 (EC: TAS); GO_0007155 (EC: IDA, PMID: 15454088); GO_0007155 (EC: TAS, PMID: 11283752); GO_0007268 (EC: TAS); GO_0007271 (EC: IBA); GO_0007399 (EC: TAS, PMID: 11283752); GO_0007416 (EC: IBA); GO_0007416 (EC: TAS, PMID: 11283752); GO_0007517 (EC: TAS, PMID: 11283752); GO_0008283 (EC: TAS, PMID: 11283752); GO_0009611 (EC: TAS, PMID: 11283752); GO_0009986 (EC: IBA); GO_0016020 (EC: IDA, PMID: 16262697); GO_0016787 (EC: IDA, PMID: 1517212); GO_0017171 (EC: IDA, PMID: 3954986); GO_0019695 (EC: IBA); GO_0030054 (EC: IEA); GO_0030424 (EC: IBA); GO_0030425 (EC: IBA); GO_0031225 (EC: IEA); GO_0031594 (EC: IBA); GO_0031623 (EC: IEA); GO_0032223 (EC: IC, PMID: 1517212); GO_0042136 (EC: TAS); GO_0042166 (EC: IDA, PMID: 8349597); GO_0042166 (EC: NAS, PMID: 1517212); GO_0042734 (EC: IBA); GO_0042803 (EC: IPI, PMID: 12524166); GO_0042803 (EC: NAS, PMID: 1517212); GO_0042982 (EC: TAS, PMID: 12769797); GO_0043236 (EC: IDA, PMID: 12524166); GO_0043621 (EC: IEA); GO_0044281 (EC: TAS); GO_0045202 (EC: IDA, PMID: 8460160); GO_0045211 (EC: IBA); GO_0045212 (EC: IEA); GO_0046474 (EC: TAS); GO_0048471 (EC: IDA, PMID: 14766237); GO_0048814 (EC: IBA); GO_0050714 (EC: TAS, PMID: 11283752); GO_0050770 (EC: IBA); GO_0051262 (EC: IEA); GO_0060041 (EC: IEA)
has PubMed association: PMID: 1380483; 1391965; 1517212; 1609795; 1744105; 1748670; 2263619; 2714437; 2734315; 3319614; 3954986; 7085778; 7836436; 8125298; 8248502; 8280063; 8299725; 8349597; 8449945; 8460160; 8488842; 9579781; 9640563; 9689136; 9811904; 9847074; 10800960; 10837146; 11002295; 11053835; 11239002; 11283752; 11799248; 11804574; 12009429; 12069617; 12081473; 12140295; 12427014; 12466963; 12477932; 12524166; 12548360; 12604711; 12609505; 12690205; 12769797; 12811800; 12851386; 12853948; 12928915; 12963741; 14766237; 15060281; 15078872; 15123727; 15161650; 15454088; 15459952; 15474030; 15488495; 15526038; 15629887; 15690550; 15715671; 15783300; 15974894; 15974920; 16213467; 16256091; 16256968; 16262697; 16289501; 16375580; 16429485; 16516310; 16801396; 16832351; 16909200; 16996687; 17192624; 17192630; 17192673; 17272501; 17320203; 17335779; 17370251; 17476278; 17503475; 17606622; 17702992; 17729290; 17948252; 17984143; 18161504; 18194455; 18215127; 18258603; 18299393; 18344198; 18454940; 18457821; 18470725; 18612832; 18769671; 18780301; 19019080; 19051205; 19086053; 19156168; 19185568; 19294450; 19327769; 19371630; 19371631; 19468687; 19730683; 19912576; 19913121; 20138030; 20156100; 20173328; 20193849; 20338155; 20356562; 20398640; 20398908; 20431033; 20433814; 20529763; 20602615; 20628086; 20883446; 20964587; 21274871; 21377978; 21473860; 21490949; 21493754; 21530001; 21576115; 21621296; 21730071; 21795704; 22142546; 22560633; 22805525; 22990020; 23047022; 23047027; 23063927; 23119107; 23440190; 23466605; 23583979; 23748235; 23897820; 23936791; 24249815; 24402754
description: acetylcholinesterase (Yt blood group)
database cross reference: Ensembl:ENSG00000087085
database cross reference: HGNC:108
database cross reference: HPRD:00010
database cross reference: MIM:100740
database cross reference: Vega:OTTHUMG00000157033

ACO1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ACONS
alternative term: HEL60
alternative term: IREB1
alternative term: IREBP
alternative term: IREBP1
alternative term: IRP1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ACO1
full name from nomenclature authority: aconitase 1, soluble
NCBI GeneID: 48
NCBI LocusTag: RP11-334P12.1
gene map location: 9p21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003723 (EC: IDA, PMID: 1946430); GO_0003723 (EC: NAS, PMID: 1903202); GO_0003994 (EC: IDA, PMID: 1946430); GO_0005515 (EC: IPI, PMID: 19762596); GO_0005737 (EC: IDA); GO_0005737 (EC: NAS, PMID: 1738601); GO_0005739 (EC: IDA); GO_0005783 (EC: IDA, PMID: 16144863); GO_0005794 (EC: IDA, PMID: 16144863); GO_0005829 (EC: IDA, PMID: 16527810); GO_0006099 (EC: IEA); GO_0006101 (EC: IDA, PMID: 16527810); GO_0006417 (EC: IEA); GO_0006879 (EC: IEA); GO_0009791 (EC: IEA); GO_0010040 (EC: IDA, PMID: 8041788); GO_0030350 (EC: IDA, PMID: 8041788); GO_0046872 (EC: IEA); GO_0050892 (EC: IEA); GO_0051539 (EC: IDA, PMID: 16407072); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1738601; 1903202; 1946430; 2172968; 2771641; 8041788; 8262977; 8764614; 9020582; 10419470; 10944468; 11783942; 11812787; 12196178; 12477932; 12572667; 12855587; 12972614; 15099026; 15342556; 15349772; 15489334; 15543932; 15938636; 16027165; 16144863; 16344560; 16407072; 16424901; 16503547; 16527810; 17127713; 17200797; 17242182; 17244191; 17521334; 17604281; 17613866; 17877204; 18029348; 18262302; 19056867; 19688112; 19762596; 19762597; 20354189; 20558735; 20569198; 20574843; 20877624; 21139048; 21360641; 21832049; 21890473; 21906983; 21963094; 22020773; 22331484; 22502979; 22505724; 22544036; 22561531; 22863883; 22939629; 23000965; 23382691; 23615448; 23817740
description: aconitase 1, soluble
database cross reference: Ensembl:ENSG00000122729
database cross reference: HGNC:117
database cross reference: HPRD:00013
database cross reference: MIM:100880
database cross reference: Vega:OTTHUMG00000019740

ACTA1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ACTA
alternative term: ASMA
alternative term: CFTD
alternative term: CFTD1
alternative term: CFTDM
alternative term: MPFD
alternative term: NEM1
alternative term: NEM2
alternative term: NEM3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ACTA1
full name from nomenclature authority: actin, alpha 1, skeletal muscle
NCBI GeneID: 58
NCBI LocusTag: RP5-1068B5.2
gene map location: 1q42.13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001725 (EC: IDA, PMID: 15198992); GO_0005200 (EC: TAS, PMID: 10508519); GO_0005515 (EC: IPI, PMID: 12849983); GO_0005524 (EC: TAS, PMID: 10508519); GO_0005615 (EC: IDA); GO_0005829 (EC: TAS); GO_0005865 (EC: IDA, PMID: 15198992); GO_0005884 (EC: IDA, PMID: 12849983); GO_0006936 (EC: TAS, PMID: 10508519); GO_0009612 (EC: IEA); GO_0009991 (EC: IEA); GO_0010226 (EC: IEA); GO_0015629 (EC: IMP, PMID: 15198992); GO_0016049 (EC: IEA); GO_0017022 (EC: TAS, PMID: 10508519); GO_0030017 (EC: IDA, PMID: 1423520); GO_0030049 (EC: TAS); GO_0030240 (EC: IMP, PMID: 11333380); GO_0043503 (EC: IEA); GO_0043531 (EC: TAS, PMID: 10508519); GO_0048545 (EC: IEA); GO_0048741 (EC: ISS); GO_0070062 (EC: IDA, PMID: 19199708); GO_0072562 (EC: IDA)
has PubMed association: PMID: 648524; 1074709; 1383230; 1423520; 1540415; 1544421; 1808202; 1907279; 1991513; 2161834; 2395459; 2455687; 2907503; 2936753; 3793760; 3842206; 6190133; 6865942; 6893424; 7503723; 7642559; 7680654; 7703225; 7780165; 7816144; 7820861; 7908020; 7908614; 8258301; 8395021; 8399167; 8413665; 8416954; 8422497; 8567732; 8612804; 8997639; 8999969; 9153421; 9199170; 9214391; 9251807; 9298982; 9417078; 9490638; 9512503; 9645951; 9668039; 9695962; 9724539; 9792688; 9832551; 9841925; 9852149; 10072583; 10224093; 10320340; 10366597; 10438535; 10491393; 10508519; 10556093; 10559237; 10564664; 10575001; 10581178; 10583954; 10601340; 10628374; 10666339; 10793131; 10806479; 10882740; 10958653; 10984435; 11018051; 11027608; 11053353; 11071908; 11090452; 11102443; 11106625; 11166164; 11171322; 11259305; 11297527; 11309382; 11333380; 11415434; 11429692; 11438522; 11441066; 11461920; 11468283; 11481347; 11524436; 11536049; 11580270; 11583571; 11687588; 11691822; 11701614; 11702052; 11707283; 11795944; 11812134; 11821948; 11839310; 11850458; 11877456; 11889126; 11897493; 11950878; 11969288; 12006649; 12033495; 12044158; 12048248; 12062430; 12119014; 12127568; 12163017; 12210873; 12383268; 12384700; 12388543; 12417592; 12417594; 12438125; 12438242; 12466270; 12475945; 12477932; 12480535; 12534372; 12554937; 12571245; 12665555; 12695497; 12714565; 12721663; 12849983; 12857853; 14506234; 14507647; 14532270; 14576350; 14592989; 14594945; 14634002; 14640694; 14668487; 14676314; 14684598; 14688263; 14690596; 14694110; 14702039; 14966270; 15059972; 15072110; 15107502; 15149849; 15152255; 15198992; 15236405; 15336687; 15454575; 15468086; 15489334; 15494313; 15507486; 15520409; 15558034; 15679046; 15772115; 16009940; 16051665; 16427282; 16461343; 16501887; 16526095; 16568092; 16751776; 16916647; 16945536; 17010111; 17082770; 17194691; 17194709; 17203973; 17266347; 17360745; 17361185; 17387733; 17411366; 17504171; 17573780; 17620599; 18063690; 18443296; 18461503; 18662664; 18775311; 18781797;…
description: actin, alpha 1, skeletal muscle
database cross reference: Ensembl:ENSG00000143632
database cross reference: HGNC:129
database cross reference: HPRD:00030
database cross reference: MIM:102610
database cross reference: Vega:OTTHUMG00000038006

ADAM10
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AD10
alternative term: AD18
alternative term: CD156c
alternative term: HsT18717
alternative term: MADM
alternative term: RAK
alternative term: kuz
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ADAM10
full name from nomenclature authority: ADAM metallopeptidase domain 10
NCBI GeneID: 102
gene map location: 15q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001701 (EC: ISS); GO_0004175 (EC: ISS); GO_0004222 (EC: IMP, PMID: 19114711); GO_0004222 (EC: NAS, PMID: 8694785); GO_0005102 (EC: NAS, PMID: 12176995); GO_0005178 (EC: NAS, PMID: 8694785); GO_0005515 (EC: IPI, PMID: 10527948); GO_0005634 (EC: ISS); GO_0005737 (EC: ISS); GO_0005794 (EC: IDA, PMID: 12475894); GO_0005798 (EC: IDA, PMID: 12475894); GO_0005886 (EC: TAS); GO_0006468 (EC: ISS); GO_0006509 (EC: IDA, PMID: 12714508); GO_0006509 (EC: IMP, PMID: 17965014); GO_0007162 (EC: IDA, PMID: 12714508); GO_0007162 (EC: NAS, PMID: 8694785); GO_0007173 (EC: TAS); GO_0007219 (EC: ISS); GO_0007219 (EC: TAS); GO_0007220 (EC: TAS); GO_0007229 (EC: NAS, PMID: 8694785); GO_0007267 (EC: NAS, PMID: 12714508); GO_0008237 (EC: IDA, PMID: 12475894); GO_0008237 (EC: IMP, PMID: 12535668); GO_0008237 (EC: TAS); GO_0008270 (EC: IEA); GO_0008284 (EC: IMP, PMID: 18373975); GO_0009986 (EC: IDA, PMID: 12475894); GO_0010820 (EC: IMP, PMID: 18373975); GO_0014069 (EC: IEA); GO_0016021 (EC: NAS, PMID: 8694785); GO_0017124 (EC: IEA); GO_0019901 (EC: ISS); GO_0022617 (EC: TAS); GO_0030198 (EC: TAS); GO_0030307 (EC: IMP, PMID: 18373975); GO_0030335 (EC: IMP, PMID: 18373975); GO_0030574 (EC: TAS); GO_0034612 (EC: IDA, PMID: 11831872); GO_0042117 (EC: IMP, PMID: 11831872); GO_0042803 (EC: ISS); GO_0051088 (EC: IMP, PMID: 18676862); GO_0051089 (EC: IDA, PMID: 12714508); GO_0070062 (EC: IDA)
has PubMed association: PMID: 7593158; 7822279; 8694785; 9016778; 9305925; 9344679; 9441766; 9618175; 10423016; 10527948; 10737800; 10958785; 11477090; 11511685; 11741929; 11786905; 11831872; 11839628; 12080182; 12176995; 12438920; 12475894; 12477932; 12535668; 12568494; 12590602; 12629514; 12665519; 12714508; 12730960; 12782344; 12794186; 12815056; 12832423; 12960155; 14627705; 14636066; 14702039; 14707550; 15182369; 15280379; 15280425; 15300588; 15507448; 15905513; 15958533; 16239146; 16263114; 16263699; 16309826; 16344560; 16390331; 16627989; 16648485; 16735514; 16751190; 16806063; 16942750; 17170699; 17187903; 17192395; 17290285; 17557115; 17699774; 17727679; 17895248; 17965014; 18074395; 18187620; 18200054; 18215140; 18355445; 18373975; 18381078; 18420943; 18480749; 18514661; 18603587; 18642355; 18676862; 18781797; 18952609; 18971959; 18979631; 18981120; 19091752; 19114711; 19144697; 19260824; 19278423; 19344981; 19357285; 19394555; 19426159; 19435795; 19541935; 19564338; 19587294; 19603142; 19608551; 19632330; 19665015; 19667218; 19672558; 19704010; 19783906; 19823572; 19826051; 19865098; 19913121; 20059578; 20070888; 20136654; 20348102; 20371803; 20381196; 20443867; 20624979; 20628086; 20676056; 20677014; 20711474; 20814017; 20863729; 21103979; 21123580; 21171968; 21196064; 21259244; 21368228; 21402705; 21441465; 21569301; 21576249; 21611732; 21625236; 21695060; 21804545; 21876729; 21906983; 21956108; 21959176; 21969210; 22006996; 22065584; 22116825; 22167753; 22268729; 22404213; 22474035; 22505724; 22572541; 22586143; 22613720; 22641052; 22689693; 22770404; 22923171; 22933306; 22939629; 22940701; 22965144; 23035126; 23124962; 23192951; 23306532; 23429442; 23460612; 23526433; 23546882; 23579328; 23666529; 23674691; 23676497; 23720309; 23746173; 23936798; 24055016; 24055471; 24121505; 24165480; 24189063; 24250222; 24286866
description: ADAM metallopeptidase domain 10
relation: Alzpathway: NPD1 leading to ADAM10; Source: https://pubmed.ncbi.nlm.nih.gov/21431475/
database cross reference: Ensembl:ENSG00000137845
database cross reference: HGNC:188
database cross reference: HPRD:03723
database cross reference: MIM:602192
database cross reference: Vega:OTTHUMG00000132633

ADRBK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BARK1
alternative term: BETA-ARK1
alternative term: GRK2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ADRBK1
full name from nomenclature authority: adrenergic, beta, receptor kinase 1
NCBI GeneID: 156
gene map location: 11q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002029 (EC: ISS); GO_0003108 (EC: IMP, PMID: 15051637); GO_0004672 (EC: ISS); GO_0004703 (EC: ISS); GO_0005515 (EC: IPI, PMID: 17006543); GO_0005524 (EC: IEA); GO_0005737 (EC: IDA, PMID: 17986524); GO_0005829 (EC: TAS); GO_0005886 (EC: TAS); GO_0007165 (EC: TAS); GO_0007173 (EC: TAS); GO_0007202 (EC: TAS); GO_0007213 (EC: ISS); GO_0007217 (EC: IDA, PMID: 17986524); GO_0007507 (EC: IEA); GO_0008543 (EC: TAS); GO_0016020 (EC: ISS); GO_0018105 (EC: ISS); GO_0018107 (EC: IEA); GO_0031623 (EC: IDA); GO_0031694 (EC: ISS); GO_0031755 (EC: IDA, PMID: 19306925); GO_0033605 (EC: ISS); GO_0038032 (EC: IEA); GO_0045087 (EC: TAS); GO_0045988 (EC: IMP, PMID: 15051637); GO_0047696 (EC: IEA); GO_0048011 (EC: TAS); GO_0060048 (EC: IMP, PMID: 15051637)
has PubMed association: PMID: 1339451; 2037065; 7836371; 7876239; 8195124; 8662816; 8885248; 9211925; 9446593; 9501202; 9618528; 9826657; 10085129; 10085131; 10091590; 10379886; 10467231; 10574913; 10617630; 10722682; 10727525; 10744734; 10754297; 10852916; 10858453; 10861009; 10884381; 10896954; 11040053; 11042191; 11278469; 11309381; 11517230; 11762794; 12107237; 12123746; 12130691; 12130708; 12163475; 12351722; 12379128; 12381737; 12435819; 12456365; 12477932; 12486133; 12507501; 12552191; 12624098; 12639913; 12679936; 12750365; 12885252; 14557268; 14654844; 14729942; 14997482; 15051637; 15097244; 15271984; 15471870; 15489334; 15542600; 15569306; 15618519; 15620700; 15653687; 15778405; 15843435; 15870073; 15919661; 16077899; 16081410; 16091361; 16094730; 16121194; 16356165; 16605244; 16725308; 16849637; 16920721; 16984558; 17000469; 17006543; 17008309; 17055984; 17102134; 17146290; 17256744; 17276003; 17482545; 17544362; 17548351; 17893145; 17986524; 17998459; 18369319; 18425130; 18451066; 18463167; 18511496; 18854154; 18976975; 19257866; 19292735; 19306925; 19338266; 19400979; 19487588; 19620130; 19815545; 19846537; 19906838; 19913121; 19953087; 20080565; 20335112; 20443852; 20443948; 20460384; 20468064; 20493668; 20501412; 20627936; 20628086; 20684281; 20696855; 20730384; 20807772; 20814022; 20861385; 21081496; 21127457; 21283592; 21357420; 21464134; 21473908; 21705320; 21784156; 21890473; 21900206; 21940795; 21952200; 21983013; 21988832; 22089113; 22193721; 22196842; 22375000; 22505724; 22589388; 22731384; 22735336; 23029581; 23076141; 23082996; 23139825; 23208013; 23221335; 23312955; 23362259; 23455922; 23460259; 23467820; 23494575; 23705503; 23734232; 23940030; 24064210; 24135140; 24169548
description: adrenergic, beta, receptor kinase 1
database cross reference: Ensembl:ENSG00000173020
database cross reference: HGNC:289
database cross reference: HPRD:00182
database cross reference: MIM:109635
database cross reference: Vega:OTTHUMG00000167104

AGER
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: RAGE
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: AGER
full name from nomenclature authority: advanced glycosylation end product-specific receptor
NCBI GeneID: 177
NCBI LocusTag: DAMA-358M23.4
gene map location: 6p21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004872 (EC: TAS, PMID: 8751438); GO_0004888 (EC: TAS, PMID: 1378843); GO_0005515 (EC: IPI, PMID: 16061848); GO_0005576 (EC: IEA); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 1378843); GO_0006954 (EC: IEA); GO_0007166 (EC: TAS, PMID: 10835680); GO_0009611 (EC: TAS, PMID: 10399917); GO_0031175 (EC: IGI, PMID: 10391939); GO_0042802 (EC: IPI); GO_0044548 (EC: IPI, PMID: 15033494); GO_0045087 (EC: TAS); GO_0050930 (EC: IEA); GO_0051092 (EC: IDA, PMID: 10391939)
has PubMed association: PMID: 1378843; 7713518; 7835890; 7887450; 8751438; 8787669; 8889548; 9195959; 9734395; 9812979; 10391939; 10399917; 10521570; 10531386; 10601334; 10835680; 11007787; 11282423; 11334430; 11375354; 11457670; 11586486; 11700025; 11739380; 11811511; 11884895; 11961018; 12029499; 12070776; 12475402; 12477623; 12477932; 12495433; 12579287; 12598893; 12606536; 12618340; 12651613; 12671312; 12837757; 12859967; 12909002; 12935895; 12941744; 14501001; 14571699; 14574404; 14580673; 14595542; 14617629; 14656967; 14704946; 14747204; 15009731; 15019601; 15033494; 15052533; 15053925; 15127201; 15155381; 15170618; 15180953; 15203887; 15213278; 15239215; 15247020; 15289604; 15448098; 15489334; 15539404; 15547674; 15555779; 15599399; 15663911; 15666359; 15666591; 15748606; 15790669; 15798956; 15803111; 15893388; 15896660; 15911356; 15915542; 15926115; 15930093; 15942078; 15942086; 15944249; 15986224; 16037279; 16052547; 16061848; 16127291; 16159602; 16166741; 16271939; 16286548; 16305072; 16374460; 16440015; 16493495; 16644647; 16716307; 16728681; 16788244; 16847147; 16899960; 16954185; 16954682; 16969646; 16969649; 17004092; 17024691; 17035340; 17158877; 17170388; 17172923; 17218539; 17224333; 17237617; 17343760; 17345061; 17355942; 17405935; 17425804; 17434489; 17474147; 17497647; 17508727; 17512509; 17536039; 17549666; 17560613; 17588956; 17592553; 17593216; 17601350; 17613396; 17639302; 17640970; 17660747; 17661837; 17700210; 17714874; 17924846; 18032526; 18046662; 18050248; 18058469; 18078623; 18079485; 18079965; 18080716; 18089847; 18179750; 18231794; 18245812; 18256374; 18279703; 18279705; 18302220; 18322992; 18339893; 18355449; 18421017; 18427074; 18431028; 18438937; 18458846; 18477569; 18480271; 18519797; 18550199; 18575614; 18576917; 18593464; 18595673; 18603587; 18606705; 18615900; 18645306; 18657529; 18660489; 18667420; 18689872; 18698218; 18701333; 18775683; 18777492; 18789567; 18796298; 18825489; 18854308; 18922799; 18926539; 18948101; 18952609; 18977241; 18987644; 1900…
description: advanced glycosylation end product-specific receptor
database cross reference: Ensembl:ENSG00000204305
database cross reference: HGNC:320
database cross reference: HPRD:02568
database cross reference: MIM:600214
database cross reference: Vega:OTTHUMG00000031120

AKT1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AKT
alternative term: CWS6
alternative term: PKB
alternative term: PKB-ALPHA
alternative term: PRKBA
alternative term: RAC
alternative term: RAC-ALPHA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: AKT1
full name from nomenclature authority: v-akt murine thymoma viral oncogene homolog 1
NCBI GeneID: 207
gene map location: 14q32.32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 14
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000060 (EC: IMP, PMID: 16280327); GO_0001649 (EC: IEA); GO_0001893 (EC: IEA); GO_0001934 (EC: IDA, PMID: 19057511); GO_0001938 (EC: IMP, PMID: 19850054); GO_0004672 (EC: TAS, PMID: 10570282); GO_0004674 (EC: IDA, PMID: 10102273); GO_0004674 (EC: TAS); GO_0005080 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11154276); GO_0005524 (EC: IC, PMID: 11994271); GO_0005524 (EC: IDA, PMID: 16540465); GO_0005547 (EC: IDA, PMID: 19203586); GO_0005634 (EC: IDA); GO_0005634 (EC: TAS); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA, PMID: 19203586); GO_0005737 (EC: ISS); GO_0005737 (EC: TAS); GO_0005819 (EC: IEA); GO_0005829 (EC: IDA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 14749367); GO_0005886 (EC: TAS); GO_0005978 (EC: IEA); GO_0005979 (EC: IMP, PMID: 8940145); GO_0006006 (EC: IEA); GO_0006412 (EC: IEA); GO_0006417 (EC: IEA); GO_0006464 (EC: TAS, PMID: 10570282); GO_0006468 (EC: IDA, PMID: 11994271); GO_0006469 (EC: IMP, PMID: 9373175); GO_0006469 (EC: ISS); GO_0006809 (EC: TAS, PMID: 10376602); GO_0006915 (EC: TAS); GO_0006924 (EC: IMP, PMID: 14749367); GO_0006954 (EC: IEA); GO_0007165 (EC: TAS); GO_0007173 (EC: TAS); GO_0007186 (EC: TAS, PMID: 10570282); GO_0007281 (EC: IEA); GO_0007568 (EC: IEA); GO_0007596 (EC: TAS); GO_0008283 (EC: TAS); GO_0008286 (EC: IMP, PMID: 8978681); GO_0008543 (EC: TAS); GO_0008637 (EC: IEA); GO_0009408 (EC: TAS, PMID: 10958679); GO_0010467 (EC: TAS); GO_0010507 (EC: IMP, PMID: 18387192); GO_0010748 (EC: IMP, PMID: 16814735); GO_0010765 (EC: IEA); GO_0010907 (EC: IMP, PMID: 16814735); GO_0010951 (EC: IMP, PMID: 18387192); GO_0010975 (EC: ISS); GO_0015630 (EC: IDA); GO_0015758 (EC: IEA); GO_0016070 (EC: TAS); GO_0016071 (EC: TAS); GO_0016301 (EC: IDA, PMID: 14749367); GO_0016310 (EC: IDA); GO_0016567 (EC: IEA); GO_0018105 (EC: IDA, PMID: 16139227); GO_0019899 (EC: ISS); GO_0030030 (EC: IEA); GO_0030154 (EC: TAS); GO_0030163 (EC: IEA); GO_0030168 (EC: TAS); GO_0030212 (EC: IEA); GO_0030235 (EC: IMP, PMID: 10376603); GO_0030307 (EC: IDA, PMID: 19203…
has PubMed association: PMID: 1533586; 1718748; 1851997; 3037531; 3384441; 7774014; 7891724; 8524413; 8940145; 8978681; 9005852; 9019819; 9312003; 9368760; 9373175; 9381178; 9394803; 9395488; 9512493; 9736715; 9768361; 9812896; 9829964; 9973250; 10082674; 10085094; 10102273; 10217147; 10224060; 10226025; 10358014; 10376602; 10376603; 10438924; 10454575; 10485710; 10485711; 10490823; 10490848; 10491192; 10497255; 10527852; 10542266; 10570282; 10576742; 10617634; 10635328; 10698680; 10748004; 10833263; 10866658; 10869359; 10869418; 10872470; 10896934; 10910062; 10926925; 10930578; 10958679; 10983986; 10995457; 11035810; 11042204; 11116148; 11139588; 11154276; 11154281; 11156376; 11156964; 11162552; 11208609; 11274386; 11278835; 11278894; 11313365; 11313479; 11404460; 11410590; 11410591; 11425855; 11438723; 11445557; 11500364; 11504915; 11508278; 11509608; 11535620; 11546794; 11579209; 11583630; 11585925; 11598301; 11689711; 11696579; 11707444; 11707464; 11710897; 11715018; 11723139; 11756412; 11773441; 11777913; 11782427; 11809791; 11825911; 11828257; 11855836; 11877387; 11884598; 11902142; 11903042; 11923280; 11956222; 11960368; 11976320; 11994271; 11994280; 12009899; 12011046; 12042314; 12062056; 12062094; 12070137; 12077256; 12112022; 12124386; 12138087; 12138205; 12145204; 12149249; 12150915; 12167664; 12167717; 12176337; 12176338; 12176997; 12194869; 12218048; 12244133; 12244301; 12244302; 12244303; 12297295; 12376533; 12393747; 12438239; 12446767; 12446787; 12446789; 12458207; 12477932; 12524439; 12527373; 12529294; 12535517; 12586360; 12592338; 12621049; 12637511; 12722480; 12727836; 12734380; 12741986; 12750378; 12757707; 12768030; 12782295; 12783873; 12791994; 12808085; 12808093; 12853467; 12874217; 12888921; 12919677; 12952968; 12972603; 14499622; 14500673; 14505491; 14520710; 14523021; 14534536; 14560023; 14566704; 14568991; 14611643; 14612949; 14623889; 14625285; 14636889; 14645242; 14645548; 14647146; 14657000; 14679206; 14702039; 14713953; 14742298; 14749367; 14749388; 14749719…
description: v-akt murine thymoma viral oncogene homolog 1
database cross reference: Ensembl:ENSG00000142208
database cross reference: HGNC:391
database cross reference: HPRD:01261
database cross reference: MIM:164730
database cross reference: Vega:OTTHUMG00000170795

ALB
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PRO0883
alternative term: PRO0903
alternative term: PRO1341
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ALB
full name from nomenclature authority: albumin
NCBI GeneID: 213
NCBI LocusTag: GIG20
gene map location: 4q13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001895 (EC: IEP); GO_0002576 (EC: TAS); GO_0003677 (EC: IDA, PMID: 16405401); GO_0005504 (EC: IDA, PMID: 16289007); GO_0005504 (EC: NAS, PMID: 9731778); GO_0005507 (EC: NAS, PMID: 14726550); GO_0005515 (EC: IPI, PMID: 16099937); GO_0005576 (EC: NAS, PMID: 14718574); GO_0005576 (EC: TAS); GO_0005604 (EC: IEA); GO_0005615 (EC: IDA, PMID: 19996109); GO_0006810 (EC: TAS, PMID: 12617161); GO_0007584 (EC: IEA); GO_0007596 (EC: TAS); GO_0008144 (EC: IDA, PMID: 16169013); GO_0008144 (EC: NAS, PMID: 10940303); GO_0008206 (EC: TAS); GO_0008270 (EC: IEA); GO_0009267 (EC: IDA, PMID: 16245148); GO_0010033 (EC: IEA); GO_0015643 (EC: IDA, PMID: 16169013); GO_0015721 (EC: TAS); GO_0016209 (EC: NAS, PMID: 14726550); GO_0019825 (EC: IDA, Qualifier: contributes_to, PMID: 16283771); GO_0019836 (EC: IDA, PMID: 16394536); GO_0019899 (EC: IEA); GO_0030168 (EC: TAS); GO_0030170 (EC: IDA, PMID: 16201370); GO_0031093 (EC: TAS); GO_0042157 (EC: TAS); GO_0043066 (EC: IDA, PMID: 16153637); GO_0043069 (EC: NAS, PMID: 14726550); GO_0043234 (EC: IDA, PMID: 16283771); GO_0043252 (EC: TAS); GO_0044281 (EC: TAS); GO_0046010 (EC: IEA); GO_0046689 (EC: IEA); GO_0051087 (EC: IPI, PMID: 19996109); GO_0051659 (EC: IDA, PMID: 16153637); GO_0055085 (EC: TAS); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070541 (EC: IEA); GO_0072562 (EC: IDA)
has PubMed association: PMID: 325004; 571335; 656055; 683332; 955075; 1225573; 1347703; 1390939; 1518850; 1602151; 1630489; 1810199; 1819460; 1859851; 1946412; 2068071; 2104980; 2247440; 2339130; 2374930; 2404284; 2419329; 2437111; 2460858; 2564675; 2727704; 2762316; 2792379; 2898383; 2901102; 2911589; 2914956; 3009475; 3081519; 3087352; 3353369; 3474609; 3479777; 3759977; 3795040; 3828358; 4027254; 4062880; 6171778; 6173750; 6192711; 6275391; 6292049; 6324579; 6457647; 6864486; 6933567; 7297678; 7557095; 7576927; 7578225; 7852505; 7882997; 7895732; 7902134; 8022807; 8048949; 8063017; 8064810; 8132774; 8134387; 8312056; 8347685; 8513793; 8605586; 8889549; 8898021; 9168236; 9183005; 9329347; 9589637; 9618718; 9731778; 10086322; 10388840; 10580404; 10780709; 10811843; 10940303; 11140838; 11145723; 11158855; 11159893; 11168369; 11483580; 11680902; 11689002; 11734007; 11743520; 11743713; 11781148; 11810025; 11847277; 11906609; 11931649; 12007569; 12009306; 12118010; 12477932; 12480711; 12566415; 12601813; 12617161; 12665801; 12732844; 12815038; 12969171; 12970360; 12975309; 13677478; 14520007; 14579113; 14687905; 14718574; 14726550; 14759223; 14983239; 15137089; 15149953; 15174051; 15210122; 15324660; 15353599; 15489334; 15502818; 15604093; 15616580; 15646839; 15716124; 15740590; 15832324; 15837789; 15890566; 15913893; 15942949; 15952740; 15996651; 16037246; 16054887; 16099937; 16153637; 16156788; 16159939; 16169013; 16169070; 16201370; 16213467; 16245148; 16253963; 16283771; 16289007; 16307046; 16324740; 16329499; 16337614; 16344560; 16394536; 16405401; 16413734; 16413740; 16413837; 16454580; 16608438; 16703327; 16705651; 16721655; 16843720; 16892178; 16916777; 16939204; 16979183; 17002873; 17048273; 17048876; 17054386; 17058928; 17064838; 17067818; 17109502; 17184834; 17200780; 17301560; 17347578; 17438360; 17460892; 17467280; 17499233; 17575979; 17587712; 17603933; 17940721; 17987802; 18028874; 18029235; 18054940; 18068661; 18178096; 18192916; 18200582; 18200583; 18256067; 18287254; 1832367…
description: albumin
database cross reference: Ensembl:ENSG00000163631
database cross reference: HGNC:399
database cross reference: HPRD:00062
database cross reference: MIM:103600
database cross reference: Vega:OTTHUMG00000129919

ALDH2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ALDH-E2
alternative term: ALDHI
alternative term: ALDM
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ALDH2
full name from nomenclature authority: aldehyde dehydrogenase 2 family (mitochondrial)
NCBI GeneID: 217
gene map location: 12q24.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004029 (EC: EXP); GO_0004030 (EC: TAS, PMID: 8903321); GO_0005759 (EC: TAS); GO_0005975 (EC: TAS, PMID: 8903321); GO_0006066 (EC: TAS, PMID: 1306115); GO_0006068 (EC: IEA); GO_0006069 (EC: TAS); GO_0006805 (EC: TAS); GO_0007268 (EC: TAS); GO_0009055 (EC: TAS, PMID: 8903321); GO_0042136 (EC: TAS); GO_0044281 (EC: TAS); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1306115; 2562960; 2838413; 2987944; 3017845; 3562250; 3582651; 3610592; 3653404; 4015823; 4065146; 6582480; 7593603; 8125298; 8290656; 8561277; 8889548; 8903321; 9195888; 9309300; 9765594; 10631996; 11051375; 11115843; 11117576; 11210104; 11238183; 11375898; 11410735; 11410744; 11468345; 11510748; 11520401; 11584144; 11600186; 11692094; 11696658; 11744614; 11748356; 11767261; 11798074; 11925062; 11966948; 12010862; 12033531; 12080432; 12082496; 12089173; 12119207; 12164325; 12168074; 12170102; 12173598; 12189549; 12198368; 12198369; 12211622; 12213289; 12223435; 12351924; 12376487; 12387818; 12419833; 12452318; 12477932; 12484509; 12492137; 12505800; 12517056; 12519453; 12545748; 12554615; 12563175; 12705718; 12706323; 12706324; 12718576; 12718671; 12739102; 12759156; 12759747; 12766630; 12777946; 12795606; 12798968; 12806963; 12824748; 12884000; 12915514; 12915519; 12940444; 14506399; 14506613; 14568296; 14597338; 14634838; 14636437; 14652286; 14691372; 14693654; 14742656; 14768474; 15008789; 15084894; 15122947; 15123334; 15126281; 15167446; 15182962; 15220553; 15242332; 15279067; 15318096; 15318097; 15318112; 15327835; 15377279; 15489334; 15511718; 15519646; 15542751; 15563966; 15569633; 15654505; 15679538; 15703303; 15714130; 15734972; 15780035; 15840430; 15842823; 15863807; 15902904; 15957669; 15957670; 15983043; 15991278; 16006997; 16046871; 16078602; 16082583; 16103445; 16108833; 16125912; 16126235; 16127737; 16135443; 16163053; 16169070; 16187278; 16235983; 16250071; 16309369; 16324524; 16332725; 16351505; 16365683; 16385179; 16404797; 16408483; 16440063; 16440362; 16499490; 16520888; 16565959; 16600530; 16608143; 16624836; 16639733; 16679343; 16679777; 16685648; 16702384; 16734278; 16758956; 16759795; 16782756; 16788276; 16792555; 16822169; 16847426; 16958672; 17033202; 17036331; 17040107; 17071628; 17134659; 17138329; 17196743; 17207821; 17285601; 17292341; 17384900; 17388993; 17454860; 17459359; 17471563; 17489985; 17517051; 17543846; 17559142; 17631…
description: aldehyde dehydrogenase 2 family (mitochondrial)
database cross reference: Ensembl:ENSG00000111275
database cross reference: HGNC:404
database cross reference: HPRD:00003
database cross reference: MIM:100650
database cross reference: Vega:OTTHUMG00000169603

ALOX5
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: 5-LO
alternative term: 5-LOX
alternative term: 5LPG
alternative term: LOG5
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ALOX5
full name from nomenclature authority: arachidonate 5-lipoxygenase
NCBI GeneID: 240
NCBI LocusTag: RP11-67C2.3
gene map location: 10q11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002540 (EC: IEA); GO_0004051 (EC: IDA); GO_0005506 (EC: IDA); GO_0005515 (EC: IPI, PMID: 11297527); GO_0005615 (EC: IDA); GO_0005635 (EC: IDA, PMID: 19233132); GO_0005635 (EC: TAS); GO_0005641 (EC: IDA, PMID: 8245774); GO_0005829 (EC: IDA, PMID: 19233132); GO_0005829 (EC: TAS); GO_0006691 (EC: TAS); GO_0016363 (EC: IDA, PMID: 19233132); GO_0019369 (EC: TAS); GO_0019370 (EC: IDA); GO_0019372 (EC: TAS); GO_0031965 (EC: IDA, PMID: 8245774); GO_0044281 (EC: TAS); GO_2001300 (EC: TAS)
has PubMed association: PMID: 1540191; 1939225; 2251250; 2565035; 2829172; 3134355; 3422434; 7556168; 7624354; 7929073; 8066098; 8125298; 8245774; 8268460; 8585605; 9079648; 9150468; 9435249; 9445303; 9639560; 10051563; 10514459; 10673219; 10779545; 11297527; 11462800; 11471199; 11785969; 11796736; 11844797; 12021253; 12107604; 12111389; 12140292; 12163367; 12234060; 12354292; 12477932; 12525578; 12629151; 12664574; 12695552; 12730086; 12751728; 12751768; 12751769; 12859962; 12893830; 12907138; 12911785; 14532840; 14702425; 14749922; 14767568; 15010818; 15219851; 15280375; 15301234; 15308583; 15616590; 15661803; 15848143; 15923196; 15933245; 16135563; 16165096; 16275640; 16293801; 16361798; 16364163; 16385451; 16402861; 16413224; 16495221; 16531984; 16537708; 16672272; 16698924; 16733792; 16750418; 16899822; 16919603; 16924104; 17018618; 17072961; 17080223; 17115186; 17236225; 17373700; 17373938; 17434678; 17460547; 17467166; 17500032; 17521309; 17616938; 17703412; 17825794; 17894944; 17909879; 17924829; 18174194; 18179798; 18180307; 18204779; 18218859; 18280718; 18295198; 18339529; 18366797; 18369664; 18398223; 18421027; 18421434; 18525291; 18571838; 18676680; 18678882; 18842779; 18843019; 18927292; 18976020; 18978352; 18991687; 18992148; 18996667; 19022417; 19053751; 19075240; 19083497; 19130089; 19131661; 19134178; 19170196; 19214143; 19224689; 19233132; 19247692; 19258923; 19390118; 19423540; 19446447; 19450127; 19473080; 19497113; 19524426; 19578796; 19625176; 19692168; 19717473; 19724895; 19807693; 19851296; 19888660; 19913121; 19919819; 19948975; 20110601; 20126469; 20128419; 20139978; 20173757; 20198315; 20372792; 20382140; 20388081; 20406964; 20438785; 20453000; 20503287; 20549218; 20592751; 20628086; 20677014; 20682687; 21098726; 21200133; 21224059; 21233389; 21296957; 21314617; 21403093; 21482803; 21540635; 21605700; 21723968; 21729626; 21832049; 21883892; 22050225; 22253131; 22282663; 22293202; 22363630; 22433003; 22516296; 22616993; 22690932; 22739369; 22808264; 22825379; 2306…
description: arachidonate 5-lipoxygenase
database cross reference: Ensembl:ENSG00000012779
database cross reference: HGNC:435
database cross reference: HPRD:01065
database cross reference: MIM:152390
database cross reference: Vega:OTTHUMG00000018081

BIN1
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AMPH2
alternative term: AMPHL
alternative term: SH3P9
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BIN1
full name from nomenclature authority: bridging integrator 1
NCBI GeneID: 274
gene map location: 2q14
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 10903846); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA); GO_0006897 (EC: IEA); GO_0008021 (EC: IEA); GO_0008283 (EC: TAS, PMID: 8782822); GO_0010468 (EC: IMP, PMID: 10412034); GO_0012502 (EC: IMP, PMID: 10412034); GO_0015629 (EC: TAS, PMID: 9182667); GO_0016032 (EC: IEA); GO_0030424 (EC: IDA); GO_0032403 (EC: IEA); GO_0042692 (EC: IEA); GO_0042802 (EC: IPI); GO_0043196 (EC: IEA); GO_0043547 (EC: IEA); GO_0043679 (EC: IEA); GO_0044300 (EC: IEA); GO_0045664 (EC: IMP, PMID: 10412034); GO_0045807 (EC: IEA); GO_0046982 (EC: IEA); GO_0048156 (EC: IPI); GO_0048708 (EC: IMP, PMID: 10412034); GO_0051020 (EC: IEA); GO_0060987 (EC: IMP, PMID: 19004523); GO_0060988 (EC: IMP, PMID: 19004523); GO_0071156 (EC: IC, PMID: 10412034)
has PubMed association: PMID: 8619474; 8725406; 8782822; 8889548; 9110174; 9182529; 9182667; 9195986; 9223448; 9280305; 9315708; 9341169; 9348539; 9356459; 9395479; 9418903; 9603201; 9736607; 10036185; 10094488; 10380878; 10391921; 10412034; 10430869; 10449755; 10652430; 10738240; 10764771; 10899172; 10903846; 11032017; 11076863; 11230166; 11256614; 11306501; 11384986; 11422041; 11709703; 12183633; 12456676; 12477932; 12532338; 12558988; 12604805; 12668730; 12773571; 12972505; 14702039; 14704274; 15207703; 15302935; 15483625; 15489336; 15992821; 16115810; 16169070; 16275660; 16381901; 16516635; 16530520; 17059209; 17081983; 17210688; 17218774; 17474147; 17611416; 17671430; 17676042; 17699764; 18029348; 18154705; 18348166; 18658220; 18817572; 18985028; 19004523; 19144635; 19322201; 19418541; 19629135; 19851296; 19915558; 20140253; 20142620; 20169111; 20198315; 20211142; 20460622; 20558387; 20927630; 21059989; 21129173; 21220176; 21321396; 21347408; 21379329; 21390209; 21447796; 21460840; 21460841; 21623381; 21627779; 21678469; 21832049; 21984944; 22005930; 22281836; 22539578; 22544318; 22810585; 22832961; 22863883; 22976291; 23202439; 23570733; 23754947
description: bridging integrator 1
database cross reference: Ensembl:ENSG00000136717
database cross reference: HGNC:1052
database cross reference: HPRD:03150
database cross reference: MIM:601248
database cross reference: Vega:OTTHUMG00000131465

APAF1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APAF-1
alternative term: CED4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APAF1
full name from nomenclature authority: apoptotic peptidase activating factor 1
NCBI GeneID: 317
gene map location: 12q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000166 (EC: TAS, PMID: 10383829); GO_0001843 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10206961); GO_0005524 (EC: IEA); GO_0005634 (EC: IEA); GO_0005829 (EC: TAS); GO_0006309 (EC: IEA); GO_0006915 (EC: TAS); GO_0006919 (EC: IDA); GO_0006952 (EC: IEA); GO_0007399 (EC: TAS, PMID: 9753320); GO_0008635 (EC: IDA, PMID: 9267021); GO_0008635 (EC: TAS); GO_0008656 (EC: NAS, PMID: 15009102); GO_0030900 (EC: IEA); GO_0042802 (EC: IEA); GO_0042981 (EC: TAS, PMID: 10441496); GO_0043065 (EC: TAS, PMID: 18309324); GO_0043293 (EC: IDA); GO_0043293 (EC: TAS, PMID: 18309324); GO_0043531 (EC: IEA); GO_0051402 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0072432 (EC: TAS, PMID: 18309324); GO_0097193 (EC: TAS, PMID: 18309324); GO_2001235 (EC: IEA)
has PubMed association: PMID: 9267021; 9390557; 9455477; 9488720; 9539746; 9651578; 9753320; 9829980; 9837928; 9878060; 9922454; 10206961; 10322433; 10364241; 10376594; 10383829; 10393175; 10441496; 10486928; 10543941; 10578182; 10702682; 10722681; 10764728; 10934467; 10949025; 11113115; 11230124; 11242052; 11389439; 11457460; 11550094; 11864614; 12021264; 12147322; 12149244; 12168954; 12477932; 12549820; 12615903; 12637514; 12804598; 12963020; 14566819; 14747474; 14993223; 15001356; 15009102; 15026369; 15033720; 15103018; 15262985; 15305193; 15378005; 15590702; 15649154; 15692060; 15703181; 15735003; 15829969; 15832174; 15832175; 15863166; 15972851; 16046141; 16098052; 16231040; 16232302; 16331630; 16420245; 16595687; 16951219; 16979168; 17081983; 17133271; 17274640; 17348858; 17361096; 17418785; 17534194; 17541304; 17603079; 17876870; 17882496; 17885667; 18029348; 18042457; 18093951; 18309324; 18373966; 18439902; 18587251; 18676680; 18719738; 18834886; 19056867; 19058789; 19074885; 19141860; 19170196; 19238172; 19322201; 19455599; 19603830; 19625176; 19662370; 19675677; 19692168; 19698783; 19801675; 19809088; 19913121; 20345447; 20379614; 20453000; 20628086; 20959405; 20977544; 21104989; 21139048; 21297999; 21528061; 21659556; 21890473; 21906983; 21922274; 22101335; 22143029; 22246185; 22335196; 22632162; 22996741; 23085065; 23207240; 23326121; 23521171; 23822711
description: apoptotic peptidase activating factor 1
database cross reference: Ensembl:ENSG00000120868
database cross reference: HGNC:576
database cross reference: HPRD:03755
database cross reference: MIM:602233
database cross reference: Vega:OTTHUMG00000170214

APBA1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: D9S411E
alternative term: LIN10
alternative term: MINT1
alternative term: X11
alternative term: X11A
alternative term: X11ALPHA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APBA1
full name from nomenclature authority: amyloid beta (A4) precursor protein-binding, family A, member 1
NCBI GeneID: 320
gene map location: 9q13-q21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001540 (EC: IEA); GO_0001701 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11083918); GO_0005546 (EC: IEA); GO_0005634 (EC: IEA); GO_0005794 (EC: IEA); GO_0005886 (EC: IEA); GO_0006461 (EC: TAS, PMID: 9614075); GO_0006886 (EC: IEA); GO_0007155 (EC: TAS, PMID: 9753324); GO_0007268 (EC: IEA); GO_0007399 (EC: TAS, PMID: 9753324); GO_0007626 (EC: IEA); GO_0008021 (EC: TAS, PMID: 9753324); GO_0008088 (EC: TAS, PMID: 9822620); GO_0010468 (EC: IEA); GO_0014047 (EC: IEA); GO_0014051 (EC: IEA); GO_0030165 (EC: IEA); GO_0032403 (EC: IEA); GO_0035264 (EC: IEA); GO_0043234 (EC: IEA); GO_0048471 (EC: IEA)
has PubMed association: PMID: 1968060; 7545337; 7678331; 7719031; 8887653; 9321393; 9395480; 9585438; 9614075; 9753324; 9822620; 9952408; 10455105; 11010978; 11036064; 11083918; 11115513; 12006486; 12016213; 12093160; 12177192; 12196555; 12514209; 12849748; 12970358; 14756819; 14960569; 14970211; 15024025; 15164053; 15563604; 15699037; 16344560; 16413130; 18836734; 19720620; 20016085; 20160714; 20379614; 20468060; 20531236; 21178287; 21763699; 22355143; 23737971
description: amyloid beta (A4) precursor protein-binding, family A, member 1
database cross reference: Ensembl:ENSG00000107282
database cross reference: HGNC:578
database cross reference: HPRD:03879
database cross reference: MIM:602414
database cross reference: Vega:OTTHUMG00000019984

APBB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FE65
alternative term: MGC:9072
alternative term: RIR
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APBB1
full name from nomenclature authority: amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
NCBI GeneID: 322
gene map location: 11p15
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001540 (EC: IPI, PMID: 18468999); GO_0001540 (EC: NAS, PMID: 8894693); GO_0001764 (EC: IEA); GO_0003682 (EC: IDA, PMID: 19343227); GO_0005515 (EC: IPI, PMID: 12972431); GO_0005634 (EC: IDA, PMID: 18468999); GO_0005634 (EC: ISS); GO_0005737 (EC: IDA, PMID: 18468999); GO_0005886 (EC: IDA); GO_0006302 (EC: IEA); GO_0006351 (EC: IEA); GO_0006355 (EC: ISS); GO_0006915 (EC: IEA); GO_0006974 (EC: IDA, PMID: 18468999); GO_0007050 (EC: ISS); GO_0007165 (EC: NAS, PMID: 8894693); GO_0007409 (EC: NAS, PMID: 12843239); GO_0007411 (EC: IEA); GO_0008134 (EC: ISS); GO_0008542 (EC: IEA); GO_0016607 (EC: IEA); GO_0030027 (EC: IDA, PMID: 12843239); GO_0030198 (EC: IEA); GO_0030308 (EC: ISS); GO_0030426 (EC: IDA, PMID: 12843239); GO_0042393 (EC: IPI, PMID: 19234442); GO_0043065 (EC: IDA, PMID: 18468999); GO_0043967 (EC: ISS); GO_0045202 (EC: IDA, PMID: 12843239); GO_0045665 (EC: IEA); GO_0045739 (EC: IEA); GO_0045893 (EC: IDA, PMID: 19343227); GO_0045944 (EC: IEA); GO_0050760 (EC: ISS); GO_0070064 (EC: IPI, PMID: 17686488)
has PubMed association: PMID: 8855266; 8887653; 8894693; 8955346; 9045663; 9407065; 9461550; 9585438; 9685356; 9738440; 9799084; 9837937; 10075692; 10081969; 10561691; 10945997; 11029529; 11065130; 11085987; 11095528; 11099823; 11115513; 11279131; 11436125; 11441186; 11517249; 11606623; 11741599; 11854179; 12089154; 12150997; 12477932; 12653567; 12727304; 12779321; 12843239; 12888553; 12972431; 14569203; 14572442; 14699153; 15037614; 15044485; 15146195; 15331662; 15489334; 15592452; 15647266; 15816856; 16049941; 16055720; 16223726; 16273093; 16332686; 16713569; 17332754; 17368826; 17512906; 17590240; 17686488; 17854420; 17855370; 18096514; 18468999; 18480379; 18550529; 18777128; 18800165; 18833287; 18922798; 19234442; 19343227; 19381069; 19913121; 20091743; 20133016; 20205790; 20405578; 20568118; 20628086; 21139048; 21145461; 21650223; 21824145; 21890473; 21900206; 21968187; 22199353; 22902274; 23000965; 23572515; 24056087
description: amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
database cross reference: Ensembl:ENSG00000166313
database cross reference: HGNC:581
database cross reference: HPRD:04087
database cross reference: MIM:602709
database cross reference: Vega:OTTHUMG00000165454

APC
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BTPS2
alternative term: DP2
alternative term: DP2.5
alternative term: DP3
alternative term: GS
alternative term: PPP1R46
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APC
full name from nomenclature authority: adenomatous polyposis coli
NCBI GeneID: 324
gene map location: 5q21-q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000281 (EC: IMP, PMID: 17570218); GO_0000776 (EC: IDA, PMID: 11283619); GO_0001822 (EC: IEA); GO_0001942 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10656683); GO_0005634 (EC: IDA, PMID: 11035805); GO_0005737 (EC: IDA, PMID: 11035805); GO_0005813 (EC: IDA, PMID: 11283619); GO_0005829 (EC: TAS); GO_0005881 (EC: IEA); GO_0005886 (EC: IDA); GO_0005886 (EC: IDA, Qualifier: colocalizes_with, PMID: 16611247); GO_0005913 (EC: IDA, Qualifier: colocalizes_with, PMID: 16611247); GO_0005923 (EC: IDA, PMID: 18502210); GO_0006461 (EC: IDA, PMID: 16188939); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0006974 (EC: IDA, PMID: 14728717); GO_0007026 (EC: IDA, PMID: 11166179); GO_0007026 (EC: IMP, PMID: 17192415); GO_0007050 (EC: IDA, PMID: 8521819); GO_0007091 (EC: IEA); GO_0007094 (EC: IMP, PMID: 17227893); GO_0007155 (EC: NAS, PMID: 8259518); GO_0007409 (EC: IEA); GO_0008013 (EC: IPI, PMID: 10773885); GO_0008017 (EC: IDA, PMID: 11166179); GO_0008285 (EC: IDA, PMID: 8521819); GO_0009798 (EC: IEA); GO_0009952 (EC: IEA); GO_0009953 (EC: IEA); GO_0009954 (EC: IEA); GO_0016328 (EC: IDA, PMID: 12072559); GO_0016477 (EC: IMP, PMID: 19151759); GO_0019887 (EC: IDA, PMID: 11972058); GO_0019901 (EC: IPI, PMID: 8638126); GO_0030027 (EC: IDA, PMID: 19151759); GO_0030335 (EC: IMP, PMID: 17192415); GO_0030858 (EC: IEA); GO_0030877 (EC: IDA, PMID: 16188939); GO_0031116 (EC: IEA); GO_0031122 (EC: IEA); GO_0031274 (EC: IMP, PMID: 17192415); GO_0032587 (EC: IDA, PMID: 19151759); GO_0032886 (EC: IMP); GO_0033077 (EC: IEA); GO_0035019 (EC: IEA); GO_0035371 (EC: IEA); GO_0042483 (EC: IEA); GO_0043065 (EC: IMP, PMID: 17227893); GO_0043409 (EC: IEA); GO_0044295 (EC: IEA); GO_0044336 (EC: IEA); GO_0044337 (EC: IEA); GO_0045295 (EC: IPI, PMID: 7890674); GO_0045296 (EC: IDA, Qualifier: NOT, PMID: 7890674); GO_0045667 (EC: IEA); GO_0045670 (EC: IEA); GO_0045732 (EC: IC, PMID: 16188939); GO_0045732 (EC: IGI, PMID: 12952940); GO_0045736 (EC: IDA, PMID: 8521819); GO_0045785 (EC: IEA); GO_0046716 (EC: IEA); GO_0…
has PubMed association: PMID: 1310068; 1338691; 1338764; 1338904; 1651562; 1651563; 1678319; 2797819; 3789010; 7606712; 7651399; 7661930; 7744883; 7833149; 7833931; 7890674; 8074697; 8111410; 8252630; 8259518; 8259519; 8383094; 8389242; 8521819; 8619474; 8638125; 8638126; 8889548; 8940264; 8990002; 9110174; 9188857; 9286858; 9298899; 9326658; 9375853; 9419979; 9482734; 9601641; 9637688; 9660858; 9707618; 9724771; 9731522; 9731533; 9734785; 9811605; 9950360; 9973276; 10074433; 10092233; 10188731; 10228155; 10330181; 10330403; 10426194; 10470088; 10545404; 10656683; 10666372; 10698523; 10749862; 10773885; 10782927; 10811618; 10926498; 10947987; 10951583; 10966653; 10982189; 11029657; 11035805; 11050185; 11076863; 11129339; 11136974; 11157977; 11159880; 11166179; 11221825; 11241320; 11241666; 11251183; 11283619; 11297546; 11348595; 11354631; 11389840; 11409872; 11466700; 11470413; 11483640; 11487538; 11487578; 11533658; 11535846; 11584047; 11585828; 11606402; 11668620; 11696170; 11707392; 11712088; 11720476; 11741105; 11748858; 11751382; 11754114; 11768389; 11768390; 11809680; 11809682; 11856748; 11868006; 11891193; 11912492; 11920497; 11921277; 11933206; 11943150; 11955436; 11956815; 11972058; 12000790; 12034871; 12045208; 12057910; 12070164; 12072559; 12093899; 12124804; 12136240; 12163385; 12173026; 12173321; 12374230; 12378616; 12387883; 12388762; 12439748; 12477932; 12485844; 12504226; 12508668; 12537656; 12538344; 12575848; 12581900; 12584179; 12606575; 12628243; 12647217; 12655564; 12737446; 12800081; 12800196; 12820959; 12856637; 12901799; 12907646; 12952940; 12955080; 14514668; 14520463; 14573780; 14574158; 14578136; 14578138; 14579148; 14624392; 14662741; 14672538; 14679305; 14691304; 14728717; 14729851; 14871261; 14961559; 14991743; 15020226; 15040027; 15108288; 15122587; 15123239; 15133491; 15161933; 15190067; 15251938; 15257316; 15266213; 15273719; 15294866; 15326380; 15327768; 15327769; 15331612; 15342556; 15355978; 15375803; 15446460; 15459959; 15507235; 15520370; 15523694; 155…
description: adenomatous polyposis coli
database cross reference: Ensembl:ENSG00000134982
database cross reference: HGNC:583
database cross reference: HPRD:01439
database cross reference: MIM:611731
database cross reference: Vega:OTTHUMG00000128806

APEH
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AARE
alternative term: ACPH
alternative term: APH
alternative term: D3F15S2
alternative term: D3S48E
alternative term: DNF15S2
alternative term: OPH
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APEH
full name from nomenclature authority: acylaminoacyl-peptide hydrolase
NCBI GeneID: 327
gene map location: 3p21.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004252 (EC: IDA, PMID: 17241160); GO_0005737 (EC: IDA); GO_0006508 (EC: IDA, PMID: 17241160); GO_0008242 (EC: IDA, PMID: 17241160); GO_0031965 (EC: IDA); GO_0044822 (EC: IDA); GO_0050435 (EC: IDA, PMID: 17241160); GO_0070062 (EC: IDA)
has PubMed association: PMID: 1521574; 1740429; 1861871; 2006156; 2392324; 2565880; 8411161; 8724851; 10395453; 10407158; 10719179; 11921441; 12000146; 12477932; 15489334; 15862967; 16169070; 16189514; 17241160; 18029348; 18781797; 20307617; 20529763; 21139048; 21297633; 21890473; 21906983; 21931648; 21963094; 21987572; 22505724; 22863883; 22939629; 23000965
description: acylaminoacyl-peptide hydrolase
database cross reference: Ensembl:ENSG00000164062
database cross reference: HGNC:586
database cross reference: HPRD:00034
database cross reference: MIM:102645
database cross reference: Vega:OTTHUMG00000156882

APEX1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APE
alternative term: APE1
alternative term: APEN
alternative term: APEX
alternative term: APX
alternative term: HAP1
alternative term: REF1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APEX1
full name from nomenclature authority: APEX nuclease (multifunctional DNA repair enzyme) 1
NCBI GeneID: 328
gene map location: 14q11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 14
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000737 (EC: IDA, PMID: 19188445); GO_0000737 (EC: TAS, PMID: 1722334); GO_0003677 (EC: IDA, PMID: 11286553); GO_0003684 (EC: IDA, PMID: 12524539); GO_0003713 (EC: IDA, PMID: 9119221); GO_0003714 (EC: TAS, PMID: 7961715); GO_0003906 (EC: IDA, PMID: 19188445); GO_0003906 (EC: TAS, PMID: 9119221); GO_0004519 (EC: IDA, PMID: 11478795); GO_0004520 (EC: TAS, PMID: 1722334); GO_0004523 (EC: TAS, PMID: 11286553); GO_0004528 (EC: TAS, PMID: 9119221); GO_0004844 (EC: TAS, PMID: 10805771); GO_0005515 (EC: IPI, PMID: 11118054); GO_0005634 (EC: IDA); GO_0005654 (EC: IDA, PMID: 17148573); GO_0005654 (EC: TAS); GO_0005667 (EC: IEA); GO_0005730 (EC: IDA, PMID: 17148573); GO_0005737 (EC: IDA, PMID: 9560228); GO_0005739 (EC: IDA); GO_0005783 (EC: TAS, PMID: 12524539); GO_0005813 (EC: IDA); GO_0005840 (EC: TAS, PMID: 12524539); GO_0006281 (EC: IDA, PMID: 9560228); GO_0006281 (EC: TAS); GO_0006284 (EC: TAS); GO_0006310 (EC: IEA); GO_0006351 (EC: IEA); GO_0006355 (EC: IEA); GO_0007568 (EC: IEA); GO_0008081 (EC: IDA, PMID: 11478795); GO_0008408 (EC: IDA, PMID: 11832948); GO_0008408 (EC: TAS, PMID: 11286553); GO_0014912 (EC: IEA); GO_0016491 (EC: IDA, PMID: 12524539); GO_0016607 (EC: IDA, PMID: 17148573); GO_0016890 (EC: IDA, PMID: 19188445); GO_0031490 (EC: IDA, PMID: 11809897); GO_0032403 (EC: IEA); GO_0042493 (EC: IEA); GO_0043488 (EC: IMP, PMID: 19401441); GO_0044822 (EC: IDA); GO_0045454 (EC: IEA); GO_0045739 (EC: IDA, PMID: 9207062); GO_0046872 (EC: IDA, PMID: 11286553); GO_0048471 (EC: IDA, PMID: 12524539); GO_0051059 (EC: IEA); GO_0055114 (EC: IDA, PMID: 12524539); GO_0070301 (EC: IEA); GO_0071320 (EC: IEA); GO_0071375 (EC: IEA); GO_0080111 (EC: IDA); GO_0090305 (EC: IDA, PMID: 11478795); GO_0090305 (EC: TAS, PMID: 11286553); GO_0090502 (EC: TAS, PMID: 11286553); GO_1900087 (EC: IEA)
has PubMed association: PMID: 1284593; 1371347; 1380454; 1380694; 1383925; 1627644; 1719477; 1722334; 7961715; 8086453; 8619474; 8621488; 8932375; 8942627; 9108029; 9110174; 9119221; 9207062; 9351835; 9361024; 9560228; 9870152; 10023679; 10559261; 10585464; 10594042; 10629618; 10667800; 10805771; 10946230; 11073998; 11084372; 11092888; 11096142; 11118054; 11133992; 11182545; 11250913; 11286553; 11452037; 11478795; 11601988; 11705870; 11707423; 11809897; 11832948; 11846302; 11866537; 11895912; 12058277; 12110916; 12161506; 12200445; 12230304; 12231548; 12237116; 12242029; 12384995; 12477932; 12480540; 12519758; 12524539; 12547389; 12555094; 12569263; 12624104; 12628186; 12842873; 12857737; 12860125; 12933815; 12966083; 14521941; 14581338; 14594818; 14599768; 14625810; 14630715; 14633989; 14643949; 14704345; 14730972; 14767913; 15044328; 15084314; 15107486; 15113441; 15210853; 15247342; 15316562; 15333465; 15362040; 15380100; 15459284; 15472121; 15489334; 15518571; 15592455; 15635413; 15644200; 15674341; 15694346; 15706084; 15731342; 15735682; 15746160; 15816625; 15824325; 15824742; 15831793; 15878096; 15887293; 15942031; 16000577; 16147991; 16195237; 16221808; 16284386; 16356936; 16406883; 16425270; 16481227; 16481390; 16492928; 16537925; 16554306; 16609022; 16621887; 16712791; 16844323; 16889694; 16956909; 16962936; 16966185; 16973282; 16978929; 16982113; 17008916; 17028303; 17034901; 17040931; 17126083; 17148573; 17177211; 17197435; 17203305; 17218168; 17222938; 17230526; 17272283; 17283177; 17324338; 17332344; 17355977; 17374727; 17403694; 17479230; 17515960; 17531525; 17555083; 17567600; 17567611; 17599408; 17614107; 17630376; 17685223; 17855454; 17898541; 17922186; 17938202; 17949784; 17974506; 17984110; 17991492; 18025089; 18029348; 18042731; 18053222; 18061304; 18091433; 18179823; 18206643; 18208837; 18263880; 18324520; 18353858; 18357393; 18393760; 18436236; 18439621; 18466396; 18478337; 18482781; 18503157; 18505345; 18515104; 18627000; 18627350; 18669164; 18672023; 18676680; 187014…
description: APEX nuclease (multifunctional DNA repair enzyme) 1
database cross reference: Ensembl:ENSG00000100823
database cross reference: HGNC:587
database cross reference: HPRD:00136
database cross reference: MIM:107748
database cross reference: Vega:OTTHUMG00000029544

APLP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APLP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APLP1
full name from nomenclature authority: amyloid beta (A4) precursor-like protein 1
NCBI GeneID: 333
gene map location: 19q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 16169070); GO_0005604 (EC: TAS, PMID: 9521588); GO_0005794 (EC: IEA); GO_0005886 (EC: IDA, PMID: 16531006); GO_0006378 (EC: IEA); GO_0006417 (EC: IEA); GO_0006897 (EC: IEA); GO_0006915 (EC: IEA); GO_0007155 (EC: IEA); GO_0007193 (EC: IC, PMID: 16531006); GO_0007399 (EC: TAS, PMID: 9521588); GO_0008201 (EC: IEA); GO_0009887 (EC: TAS, PMID: 9521588); GO_0016021 (EC: IEA); GO_0030198 (EC: IEA); GO_0030818 (EC: IDA, PMID: 16531006); GO_0030900 (EC: IEA); GO_0031694 (EC: IPI, PMID: 16531006); GO_0031695 (EC: IPI, PMID: 16531006); GO_0031696 (EC: IPI, PMID: 16531006); GO_0042802 (EC: IPI, PMID: 16193067); GO_0046914 (EC: IEA); GO_0048471 (EC: IDA, PMID: 16531006); GO_0071874 (EC: IDA, PMID: 16531006)
has PubMed association: PMID: 7494461; 7929392; 8432545; 8894693; 9428684; 9521588; 9729270; 9890987; 10081969; 10460257; 10578233; 11247302; 12135352; 12228233; 12477932; 12779321; 14563850; 14597230; 14699153; 14702039; 14970212; 14983046; 15146195; 15208260; 15383276; 15489334; 16169070; 16193067; 16344553; 16531006; 17620599; 17709753; 18272596; 18430897; 19126676; 19401174; 20049724; 21178287; 21574595; 21900206; 21952790; 22178872; 23864651; 23874953
description: amyloid beta (A4) precursor-like protein 1
database cross reference: Ensembl:ENSG00000105290
database cross reference: HGNC:597
database cross reference: HPRD:00102
database cross reference: MIM:104775
database cross reference: Vega:OTTHUMG00000180692

APLP2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APLP-2
alternative term: APPH
alternative term: APPL2
alternative term: CDEBP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APLP2
full name from nomenclature authority: amyloid beta (A4) precursor-like protein 2
NCBI GeneID: 334
gene map location: 11q24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001967 (EC: IEA); GO_0003677 (EC: NAS, PMID: 7702756); GO_0004867 (EC: IEA); GO_0005515 (EC: IPI, PMID: 16193067); GO_0005634 (EC: IDA, PMID: 7702756); GO_0005886 (EC: IEA); GO_0006878 (EC: IEA); GO_0007176 (EC: IEA); GO_0007186 (EC: NAS, PMID: 8220435); GO_0007617 (EC: IEA); GO_0007626 (EC: IEA); GO_0008201 (EC: IEA); GO_0008203 (EC: IEA); GO_0009790 (EC: IEA); GO_0016021 (EC: NAS, PMID: 8485127); GO_0030198 (EC: IEA); GO_0030900 (EC: IEA); GO_0030901 (EC: IEA); GO_0042802 (EC: IPI, PMID: 16193067); GO_0043393 (EC: IEA); GO_0046914 (EC: IEA); GO_0050885 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19199708)
has PubMed association: PMID: 7539437; 7702756; 7929392; 8020984; 8125298; 8220435; 8485127; 8855266; 8894693; 9109675; 9461550; 9556595; 10081969; 10460257; 10490823; 10702673; 11247302; 11443060; 11746496; 12228233; 12372026; 12477932; 12499552; 12595709; 12917434; 14597230; 14699153; 14702039; 14970212; 14983046; 15146195; 15208260; 15231748; 15489334; 15584916; 15778465; 16193067; 16279945; 16622416; 16645641; 17371289; 17405931; 17452623; 17709753; 18452037; 18641335; 19019082; 19126676; 19184004; 19199708; 19322201; 19808674; 20195357; 20379614; 20732423; 20936779; 21081666; 21103663; 21139048; 21178287; 21459473; 21522131; 21695060; 21826533; 21875946; 21890473; 21906983; 21952790; 21963094; 21987572; 21988832; 22641691; 22797723; 23000965; 23430252
description: amyloid beta (A4) precursor-like protein 2
database cross reference: Ensembl:ENSG00000084234
database cross reference: HGNC:598
database cross reference: HPRD:00103
database cross reference: MIM:104776
database cross reference: Vega:OTTHUMG00000165767

APOC1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APOC1
full name from nomenclature authority: apolipoprotein C-I
NCBI GeneID: 341
gene map location: 19q13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004859 (EC: IDA, PMID: 2302419); GO_0005504 (EC: IDA, PMID: 17339654); GO_0005783 (EC: IDA); GO_0006629 (EC: TAS, PMID: 2897845); GO_0006641 (EC: IEA); GO_0008203 (EC: IEA); GO_0010873 (EC: TAS, PMID: 18992221); GO_0010900 (EC: IDA, PMID: 2302419); GO_0010916 (EC: IDA, PMID: 1917954); GO_0031210 (EC: TAS, PMID: 2302419); GO_0032374 (EC: IC, PMID: 15576844); GO_0032375 (EC: IDA, PMID: 10978346); GO_0033344 (EC: IDA, PMID: 11162594); GO_0033700 (EC: IDA, PMID: 11162594); GO_0034361 (EC: IDA, PMID: 15576844); GO_0034364 (EC: IDA, PMID: 15576844); GO_0034369 (EC: IDA, PMID: 10978346); GO_0034375 (EC: TAS, PMID: 18992221); GO_0034379 (EC: TAS, PMID: 18992221); GO_0034382 (EC: IDA, PMID: 4020294); GO_0034447 (EC: IGI, PMID: 15576844); GO_0042157 (EC: IEA); GO_0042627 (EC: TAS, PMID: 18992221); GO_0043085 (EC: TAS, PMID: 18992221); GO_0045717 (EC: IDA, PMID: 15576844); GO_0045833 (EC: IDA, PMID: 182536); GO_0048261 (EC: IDA, PMID: 1917954); GO_0050995 (EC: IDA, PMID: 15576844); GO_0051005 (EC: IDA, PMID: 15576844); GO_0055102 (EC: IDA, PMID: 15576844); GO_0060228 (EC: TAS, PMID: 18992221)
has PubMed association: PMID: 166984; 182536; 1917954; 2302419; 2835369; 2897845; 2985493; 3013172; 3017837; 4020294; 4369340; 6328444; 6789904; 7471419; 7779782; 8125298; 8432525; 8804993; 9300485; 10391210; 10520737; 10978346; 11054415; 11076863; 11162594; 11256614; 11702052; 11825674; 11991719; 12032151; 12044170; 12113906; 12220441; 12429068; 12477932; 12678662; 12705839; 12736801; 12805445; 12860251; 12962909; 14523051; 14705977; 14746139; 15077570; 15174051; 15339254; 15364690; 15489334; 15489336; 15576844; 15767578; 15769335; 15777558; 15793777; 15840864; 15900219; 16159884; 16381901; 16459141; 16478678; 16544732; 16608402; 16631424; 16763159; 16935938; 16981907; 17053273; 17254710; 17310220; 17339654; 17341095; 17463246; 17474819; 17667986; 17761674; 17936795; 17975299; 17998437; 18037960; 18049452; 18160739; 18193043; 18193044; 18262040; 18667498; 18802019; 18835943; 18976728; 18984910; 18992221; 19014618; 19060906; 19062221; 19197348; 19252179; 19336475; 19336575; 19368908; 19417222; 19494537; 19567438; 19761869; 19785722; 19808960; 19812053; 19913121; 19936222; 20145290; 20209111; 20308432; 20331378; 20339536; 20430392; 20442857; 20498921; 20571754; 20580041; 20628086; 20686565; 20691829; 20714348; 20864672; 20880607; 20972250; 21103663; 21187063; 21196492; 21267442; 21300955; 21533863; 21740922; 21900206; 21909108; 21943158; 22003152; 22005931; 22022282; 22054870; 22264166; 22286219; 22404376; 22474067; 22710912; 22832961; 22995522; 23031429; 23118302; 23419831; 23455636; 23555584; 23726366; 24023261; 24121499
description: apolipoprotein C-I

APOC4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APO-CIV
alternative term: APOC-IV
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APOC4
full name from nomenclature authority: apolipoprotein C-IV
NCBI GeneID: 346
gene map location: 19q13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005319 (EC: TAS, PMID: 8530039); GO_0006629 (EC: TAS, PMID: 8530039); GO_0010890 (EC: IMP, PMID: 18809223); GO_0034361 (EC: IDA, PMID: 12700345); GO_0034361 (EC: IMP, PMID: 8827523); GO_0034364 (EC: IDA, PMID: 12700345); GO_0070328 (EC: IMP, PMID: 8827523)
has PubMed association: PMID: 8530039; 8827523; 8910501; 10996355; 11752456; 12032151; 12477932; 12700345; 15489334; 16335952; 16344560; 16763159; 17154273; 18193043; 18193044; 18802019; 18809223; 19060906; 19197348; 19336475; 19913121; 20331378; 20430392; 20498921; 20571754; 20602615; 20628086; 20714348; 20855565; 20864672; 20972250; 21103663; 21943158
description: apolipoprotein C-IV
database cross reference: Ensembl:ENSG00000267467
database cross reference: HGNC:611
database cross reference: HPRD:02848
database cross reference: MIM:600745
database cross reference: Vega:OTTHUMG00000180845

APOE
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
subclass of: Restriction
  on property: molecularly interacts with
  some values from: cholesterol
subclass of: Restriction
  on property: molecularly interacts with
  some values from: amyloid-beta
subclass of: Restriction
  on property: molecularly interacts with
  some values from: VLDLR
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AD2
alternative term: LDLCQ5
alternative term: LPG
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APOE
full name from nomenclature authority: apolipoprotein E
NCBI GeneID: 348
gene map location: 19q13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000302 (EC: NAS, PMID: 11743999); GO_0001523 (EC: TAS); GO_0001540 (EC: IDA, PMID: 11305869); GO_0001937 (EC: IDA, PMID: 9685360); GO_0002021 (EC: IEA); GO_0005319 (EC: IDA, PMID: 17305370); GO_0005515 (EC: IPI, PMID: 12950167); GO_0005543 (EC: IDA, PMID: 4066713); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA); GO_0005737 (EC: NAS, PMID: 8083695); GO_0005737 (EC: TAS, PMID: 9622609); GO_0005769 (EC: TAS); GO_0005770 (EC: IEA); GO_0005794 (EC: IEA); GO_0005886 (EC: TAS); GO_0006641 (EC: IDA, PMID: 9649566); GO_0006641 (EC: IMP, PMID: 3771793); GO_0006707 (EC: IEA); GO_0006874 (EC: IEA); GO_0006898 (EC: IDA, PMID: 1917954); GO_0007010 (EC: TAS, PMID: 9622609); GO_0007186 (EC: IDA, PMID: 16443932); GO_0007263 (EC: IDA, PMID: 8995232); GO_0007271 (EC: TAS, PMID: 9622609); GO_0007568 (EC: IEA); GO_0007603 (EC: TAS); GO_0008201 (EC: IDA, PMID: 2745454); GO_0008203 (EC: IDA, PMID: 9649566); GO_0008203 (EC: IMP, PMID: 3771793); GO_0008219 (EC: IEA); GO_0008289 (EC: IDA, PMID: 4066713); GO_0010544 (EC: IDA, PMID: 8995232); GO_0010873 (EC: IDA, PMID: 15654758); GO_0010875 (EC: IDA, PMID: 14754908); GO_0010875 (EC: IGI, PMID: 12401887); GO_0014012 (EC: IEA); GO_0016209 (EC: IDA, PMID: 9685360); GO_0017127 (EC: IEA); GO_0019934 (EC: IDA, PMID: 8995232); GO_0030195 (EC: IDA, PMID: 8995232); GO_0030425 (EC: NAS, PMID: 8083695); GO_0030516 (EC: TAS, PMID: 9622609); GO_0030828 (EC: IDA, PMID: 8995232); GO_0031232 (EC: IEA); GO_0032489 (EC: IDA, PMID: 16443932); GO_0032526 (EC: IEA); GO_0032805 (EC: IDA, PMID: 15950758); GO_0032868 (EC: IEA); GO_0033344 (EC: IDA, PMID: 11162594); GO_0033700 (EC: IDA, PMID: 11162594); GO_0034361 (EC: IDA, PMID: 17154273); GO_0034362 (EC: IDA, PMID: 8245722); GO_0034363 (EC: IDA, PMID: 17336988); GO_0034364 (EC: IDA, PMID: 210174); GO_0034372 (EC: IDA, PMID: 15654758); GO_0034372 (EC: IGI, PMID: 12401887); GO_0034374 (EC: IEA); GO_0034375 (EC: IGI, PMID: 12401887); GO_0034380 (EC: IDA, PMID: 17305370); GO_0034382 (EC: IMP, PMID: 7175379); GO_0034384 …
has PubMed association: PMID: 210174; 210175; 759055; 1356443; 1360898; 1361196; 1384047; 1617762; 1674745; 1713245; 1730728; 1917954; 2063194; 2101409; 2313204; 2341812; 2470732; 2498325; 2539388; 2556398; 2738044; 2745454; 2760009; 2779654; 2851587; 2987927; 2992507; 3038959; 3243553; 3283935; 3771793; 3922972; 3947350; 4066713; 4345202; 6199196; 6289314; 6323533; 6325438; 6327682; 6897404; 7068630; 7175379; 7263700; 7498414; 7566652; 7581381; 7586659; 7635945; 7761390; 7768901; 7797576; 7833947; 7972031; 8063017; 8083695; 8127890; 8245722; 8287539; 8300609; 8346443; 8488843; 8620924; 8624078; 8626535; 8756331; 8995232; 9012418; 9147408; 9218423; 9236223; 9360638; 9512010; 9622609; 9649566; 9685360; 9831625; 9869645; 9931331; 10520737; 10559559; 10662539; 10850798; 10962542; 10993992; 11030801; 11032626; 11033977; 11042151; 11055796; 11058710; 11060506; 11061249; 11063158; 11064931; 11072138; 11074789; 11076057; 11079660; 11095479; 11095526; 11096027; 11099722; 11100124; 11106322; 11109009; 11110974; 11113217; 11118024; 11118260; 11118404; 11118932; 11119301; 11121165; 11125748; 11126401; 11129109; 11129992; 11140838; 11140944; 11141572; 11143490; 11152862; 11153762; 11156623; 11157409; 11160955; 11162594; 11166913; 11166947; 11171287; 11171894; 11172628; 11173876; 11173877; 11173882; 11176958; 11177205; 11182472; 11204323; 11218879; 11229422; 11231028; 11236867; 11244490; 11254923; 11256794; 11257253; 11257255; 11259129; 11269459; 11269753; 11273849; 11273909; 11277566; 11280044; 11281447; 11281508; 11285089; 11295126; 11299424; 11302074; 11303757; 11305732; 11305851; 11305869; 11311499; 11315514; 11320185; 11326299; 11328206; 11332642; 11334266; 11334897; 11340230; 11341749; 11343612; 11343837; 11351136; 11354629; 11355019; 11357958; 11359065; 11360807; 11376902; 11378846; 11383910; 11388660; 11398147; 11401504; 11401610; 11412677; 11420577; 11420784; 11421127; 11421132; 11421580; 11422615; 11431078; 11434425; 11445282; 11445633; 11454010; 11456487; 11458997; 11463413; 11471927; 114724…
description: apolipoprotein E
relation: Alzpathway: APOE-cholesterol transport. Source: https://pubmed.ncbi.nlm.nih.gov/23620513/
relation: Alzpathway: LRP8-APOE association. Source: https://pubmed.ncbi.nlm.nih.gov/17428983/
relation: Alzpathway: VLDLR-APOE association. Source: https://pubmed.ncbi.nlm.nih.gov/28292942/
database cross reference: Ensembl:ENSG00000130203
database cross reference: HGNC:613
database cross reference: HPRD:00135
database cross reference: MIM:107741
database cross reference: Vega:OTTHUMG00000128901

APP
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: molecularly interacts with
  some values from: SORL1
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AAA
alternative term: ABETA
alternative term: ABPP
alternative term: AD1
alternative term: APPI
alternative term: CTFgamma
alternative term: CVAP
alternative term: PN-II
alternative term: PN2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APP
full name from nomenclature authority: amyloid beta (A4) precursor protein
NCBI GeneID: 351
gene map location: 21q21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 21
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000085 (EC: ISS); GO_0001967 (EC: IEA); GO_0002576 (EC: TAS); GO_0003677 (EC: ISS); GO_0004867 (EC: IDA, PMID: 10652580); GO_0005102 (EC: IPI, PMID: 19849849); GO_0005515 (EC: IPI, PMID: 10049767); GO_0005576 (EC: TAS); GO_0005737 (EC: IDA, PMID: 18509662); GO_0005737 (EC: ISS); GO_0005794 (EC: IDA); GO_0005794 (EC: ISS); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 12805363); GO_0005887 (EC: TAS, PMID: 10806211); GO_0005905 (EC: IEA); GO_0006378 (EC: ISS); GO_0006417 (EC: ISS); GO_0006468 (EC: ISS); GO_0006878 (EC: ISS); GO_0006897 (EC: ISS); GO_0006979 (EC: IEA); GO_0007155 (EC: IEA); GO_0007176 (EC: ISS); GO_0007219 (EC: IEA); GO_0007409 (EC: ISS); GO_0007596 (EC: TAS); GO_0007617 (EC: ISS); GO_0007626 (EC: ISS); GO_0008088 (EC: ISS); GO_0008201 (EC: IEA); GO_0008203 (EC: IEA); GO_0008344 (EC: ISS); GO_0008542 (EC: ISS); GO_0009986 (EC: IDA, PMID: 7593229); GO_0010951 (EC: IDA, PMID: 10652580); GO_0010971 (EC: IEA); GO_0016021 (EC: ISS); GO_0016199 (EC: ISS); GO_0016322 (EC: ISS); GO_0016358 (EC: ISS); GO_0016504 (EC: IEA); GO_0030168 (EC: TAS); GO_0030198 (EC: ISS); GO_0030198 (EC: TAS); GO_0030424 (EC: ISS); GO_0030900 (EC: IEA); GO_0031093 (EC: TAS); GO_0031175 (EC: ISS); GO_0031594 (EC: IEA); GO_0033130 (EC: IPI, PMID: 10681545); GO_0035235 (EC: ISS); GO_0035253 (EC: IEA); GO_0035872 (EC: TAS); GO_0040014 (EC: ISS); GO_0042802 (EC: IPI, PMID: 16193067); GO_0043197 (EC: IDA, PMID: 11988176); GO_0043198 (EC: IDA, PMID: 11988176); GO_0043231 (EC: IDA); GO_0043235 (EC: IDA); GO_0043393 (EC: IEA); GO_0045087 (EC: TAS); GO_0045177 (EC: IEA); GO_0045202 (EC: IDA, PMID: 11988176); GO_0045665 (EC: IEA); GO_0045931 (EC: ISS); GO_0045944 (EC: IEA); GO_0046914 (EC: IEA); GO_0048471 (EC: IDA); GO_0048669 (EC: ISS); GO_0050803 (EC: ISS); GO_0050885 (EC: IEA); GO_0051124 (EC: IEA); GO_0051233 (EC: IEA); GO_0051402 (EC: IMP, PMID: 19225519); GO_0051425 (EC: IPI, PMID: 12805363); GO_0051563 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19199708); GO_0070851 (EC: IEA)
has PubMed association: PMID: 1302033; 1303239; 1303244; 1303275; 1307241; 1353447; 1363811; 1415269; 1587857; 1671712; 1678058; 1679289; 1707846; 1718421; 1907279; 1908231; 1908403; 1925564; 1944558; 1969731; 2110105; 2110384; 2111584; 2119582; 2125487; 2190106; 2506449; 2507928; 2538123; 2569763; 2675837; 2783775; 2834384; 2881207; 2893289; 2893290; 2893291; 2893379; 2900137; 2949367; 3035574; 3140222; 3159021; 3312495; 3597385; 3810169; 7516706; 7523115; 7543026; 7556457; 7568089; 7588758; 7593229; 7686976; 7688497; 7699335; 7737970; 7793988; 7913895; 8032873; 8102836; 8109908; 8131745; 8154870; 8158260; 8229004; 8239320; 8248178; 8267572; 8290042; 8328966; 8344894; 8446172; 8473906; 8476439; 8478942; 8499923; 8576160; 8577393; 8596911; 8624131; 8626687; 8752142; 8764598; 8781550; 8855266; 8886002; 8887653; 8889548; 8894693; 8930981; 8943232; 8955346; 8973180; 8999878; 9045663; 9108164; 9136074; 9163350; 9168929; 9223340; 9228033; 9300481; 9328472; 9338779; 9357988; 9444352; 9461550; 9553108; 9585534; 9693002; 9754958; 9774383; 9799084; 9830016; 9837937; 9843960; 9890987; 10048303; 10049767; 10075692; 10078972; 10081969; 10097173; 10201399; 10319819; 10329371; 10341243; 10371197; 10383380; 10413512; 10438520; 10441572; 10460257; 10461923; 10527458; 10531052; 10531386; 10535332; 10559559; 10561592; 10567208; 10593990; 10605825; 10631141; 10652580; 10665499; 10681545; 10742146; 10801777; 10806211; 10816430; 10821838; 10830953; 10867787; 10884510; 10911620; 10922078; 10931940; 10936190; 10940221; 10940222; 10953012; 10973933; 10993067; 11063718; 11085987; 11100124; 11144355; 11146006; 11214319; 11238726; 11247302; 11274207; 11278849; 11279131; 11279603; 11297421; 11350084; 11376898; 11378243; 11409420; 11423558; 11430884; 11438549; 11500807; 11517218; 11517249; 11528419; 11544248; 11568920; 11580253; 11589915; 11689470; 11724784; 11726805; 11756677; 11775062; 11784781; 11809755; 11823458; 11827488; 11831556; 11851430; 11877420; 11879646; 11882652; 11912196; 11912198; 11912199; 11915325; 11…
description: amyloid beta (A4) precursor protein
relation: Alzpathway: APP-SORL1 association. Source: https://pubmed.ncbi.nlm.nih.gov/16174740/
database cross reference: Ensembl:ENSG00000142192
database cross reference: HGNC:620
database cross reference: HPRD:00100
database cross reference: MIM:104760
database cross reference: Vega:OTTHUMG00000078438

FAS
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ALPS1A
alternative term: APO-1
alternative term: APT1
alternative term: CD95
alternative term: FAS1
alternative term: FASTM
alternative term: TNFRSF6
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: FAS
full name from nomenclature authority: Fas cell surface death receptor
NCBI GeneID: 355
NCBI LocusTag: RP11-399O19.7
gene map location: 10q24.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002377 (EC: IEA); GO_0003014 (EC: IEA); GO_0004871 (EC: TAS, PMID: 10875918); GO_0004872 (EC: NAS, PMID: 7533181); GO_0004888 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10918185); GO_0005634 (EC: IDA); GO_0005737 (EC: IDA); GO_0005829 (EC: NAS, PMID: 7533181); GO_0005886 (EC: IDA); GO_0005886 (EC: IMP); GO_0005886 (EC: TAS); GO_0006461 (EC: TAS, PMID: 10875918); GO_0006915 (EC: IDA, PMID: 9681877); GO_0006915 (EC: TAS); GO_0006919 (EC: TAS); GO_0006924 (EC: IEA); GO_0006925 (EC: IEA); GO_0006927 (EC: IEA); GO_0007165 (EC: TAS, PMID: 9360929); GO_0008625 (EC: IEA); GO_0009636 (EC: IEA); GO_0009897 (EC: IEA); GO_0009986 (EC: IDA); GO_0016021 (EC: IEA); GO_0019724 (EC: IEA); GO_0019900 (EC: IPI, PMID: 7538908); GO_0031264 (EC: IDA, PMID: 11101870); GO_0031265 (EC: IDA); GO_0032464 (EC: IEA); GO_0042802 (EC: IPI); GO_0042981 (EC: NAS, PMID: 7533181); GO_0043065 (EC: IDA); GO_0043065 (EC: IMP); GO_0043066 (EC: IEA); GO_0045060 (EC: IEA); GO_0045121 (EC: IDA); GO_0045619 (EC: IEA); GO_0045637 (EC: IEA); GO_0048536 (EC: IEA); GO_0050869 (EC: IEA); GO_0051260 (EC: IEA); GO_0051384 (EC: IEA); GO_0070062 (EC: IDA); GO_0071260 (EC: IEP, PMID: 19593445); GO_0071285 (EC: IEA); GO_0071455 (EC: IMP); GO_0097049 (EC: IEA); GO_0097190 (EC: TAS); GO_0097191 (EC: IMP); GO_0097192 (EC: IEA); GO_0097527 (EC: IMP, PMID: 16507998); GO_2001239 (EC: TAS); GO_2001241 (EC: IEA)
has PubMed association: PMID: 1375228; 1385299; 1385309; 1713127; 2469768; 2787530; 7510905; 7514572; 7529798; 7530336; 7533181; 7536190; 7536343; 7538907; 7538908; 7539892; 7540117; 7542559; 7543095; 7575433; 7859281; 8521815; 8524870; 8598453; 8626376; 8648105; 8681376; 8780394; 8864141; 8906799; 8929361; 8940097; 8967952; 8976184; 9002959; 9028321; 9028957; 9039262; 9045686; 9079683; 9082980; 9126929; 9159204; 9199966; 9208847; 9215629; 9223324; 9226175; 9228058; 9247148; 9257699; 9263011; 9267021; 9268734; 9322534; 9325248; 9360929; 9427646; 9475352; 9560245; 9681877; 9721089; 9727492; 9740801; 9751072; 9787134; 9821419; 9835052; 9847311; 9857224; 9920849; 9927496; 9971775; 10068040; 10072505; 10090885; 10200300; 10235259; 10340403; 10462485; 10505674; 10506221; 10535980; 10542291; 10620127; 10625668; 10630977; 10671224; 10706119; 10709732; 10713117; 10799864; 10871852; 10875918; 10918185; 10978533; 11003656; 11034606; 11035039; 11036836; 11048727; 11048730; 11101867; 11101870; 11112409; 11129341; 11177389; 11193028; 11208609; 11298454; 11323689; 11418480; 11436125; 11483955; 11495919; 11550967; 11606059; 11692157; 11733515; 11771526; 11773067; 11779855; 11782802; 11786482; 11786908; 11788891; 11790791; 11809905; 11824955; 11830507; 11836578; 11857317; 11861273; 11864613; 11867183; 11877055; 11891278; 11895550; 11909874; 11920253; 11941452; 11949822; 11961305; 11965496; 11975981; 11986289; 11994542; 12021072; 12032668; 12034188; 12037669; 12040174; 12049185; 12060388; 12060768; 12064832; 12067476; 12096347; 12096925; 12098516; 12107169; 12131184; 12137598; 12139945; 12140383; 12150947; 12163388; 12169207; 12177303; 12185583; 12188927; 12196516; 12198154; 12207331; 12207908; 12220552; 12221075; 12234263; 12244143; 12270344; 12324452; 12372427; 12388693; 12393468; 12393649; 12393889; 12397013; 12414525; 12415011; 12419941; 12452031; 12455036; 12466128; 12477932; 12482410; 12482505; 12485855; 12497631; 12507389; 12513829; 12515395; 12515623; 12516573; 12557947; 12581154; 12583439; 1258673…
description: Fas cell surface death receptor
database cross reference: Ensembl:ENSG00000026103
database cross reference: HGNC:11920
database cross reference: HPRD:00609
database cross reference: MIM:134637
database cross reference: Vega:OTTHUMG00000018701

RHOA
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ARH12
alternative term: ARHA
alternative term: RHO12
alternative term: RHOH12
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RHOA
full name from nomenclature authority: ras homolog family member A
NCBI GeneID: 387
gene map location: 3p21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003924 (EC: TAS, PMID: 10436159); GO_0005515 (EC: IPI, PMID: 10051605); GO_0005525 (EC: IEA); GO_0005829 (EC: TAS); GO_0005856 (EC: IEA); GO_0005886 (EC: TAS); GO_0005938 (EC: IDA, PMID: 16103226); GO_0006184 (EC: TAS, PMID: 10436159); GO_0007179 (EC: TAS); GO_0007264 (EC: TAS); GO_0007266 (EC: TAS, PMID: 10436159); GO_0007411 (EC: TAS); GO_0007596 (EC: TAS); GO_0016032 (EC: IEA); GO_0017022 (EC: IPI, PMID: 15644318); GO_0021762 (EC: IEP); GO_0030027 (EC: ISS); GO_0030036 (EC: TAS, PMID: 10436159); GO_0030054 (EC: TAS); GO_0030168 (EC: TAS); GO_0030334 (EC: IMP, PMID: 19934221); GO_0030496 (EC: IEA); GO_0032154 (EC: IEA); GO_0032467 (EC: IMP, PMID: 16103226); GO_0033688 (EC: ISS); GO_0036089 (EC: IDA, PMID: 16103226); GO_0042346 (EC: NAS, PMID: 12761501); GO_0043123 (EC: IEP, PMID: 12761501); GO_0043296 (EC: IDA); GO_0043297 (EC: IMP); GO_0043931 (EC: ISS); GO_0045666 (EC: IMP, PMID: 17488780); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0050770 (EC: TAS); GO_0050771 (EC: TAS); GO_0050772 (EC: TAS); GO_0051056 (EC: TAS); GO_0051496 (EC: IDA, PMID: 15467718); GO_0061383 (EC: ISS); GO_0070062 (EC: IDA, PMID: 19056867); GO_0090307 (EC: IMP, PMID: 19635168)
has PubMed association: PMID: 1328215; 1556108; 2407642; 3822842; 7835413; 7989340; 8039707; 8125298; 8491184; 8543060; 8571127; 8617235; 8641286; 8662891; 8769096; 8798490; 8816443; 8910519; 9113980; 9121475; 9199174; 9302995; 9354661; 9407060; 9446575; 9490022; 9535835; 9535855; 9545299; 9548756; 9565577; 9582072; 9605859; 9614111; 9635436; 9647788; 9799233; 9804788; 9857026; 10051605; 10066731; 10220378; 10388627; 10436159; 10489445; 10523675; 10526156; 10595511; 10619026; 10713718; 10748207; 10854437; 10896672; 10940294; 10947987; 10948190; 11085924; 11149925; 11157984; 11162552; 11284700; 11311142; 11335720; 11350930; 11368848; 11373293; 11432776; 11560922; 11591790; 11672528; 11689693; 11696353; 11741970; 11751986; 11779461; 11786539; 11788600; 11818523; 11822867; 11830497; 11830597; 11839748; 11839765; 11889037; 11907271; 11909943; 11927263; 11948427; 11998687; 12006984; 12016230; 12062101; 12071848; 12093360; 12115629; 12119292; 12154081; 12169092; 12221077; 12221096; 12244193; 12397214; 12401808; 12423633; 12432077; 12445208; 12446789; 12454018; 12466390; 12477932; 12482610; 12490434; 12515866; 12524425; 12533515; 12534282; 12538863; 12579323; 12584113; 12593858; 12654918; 12692008; 12692556; 12719789; 12748184; 12761501; 12766172; 12773565; 12777804; 12805219; 12808121; 12842009; 12847276; 12857875; 12879077; 12900402; 12938929; 12939257; 12944407; 12951563; 12972426; 12972601; 14506264; 14514689; 14530271; 14581471; 14605490; 14612927; 14644158; 14657501; 14660612; 14749388; 15003991; 15009099; 15016733; 15023524; 15068789; 15069594; 15075243; 15085137; 15096506; 15102021; 15102857; 15125835; 15128850; 15155793; 15184877; 15208091; 15210811; 15298851; 15308673; 15322077; 15331592; 15448013; 15467718; 15475352; 15475381; 15489334; 15530360; 15535843; 15557193; 15574779; 15579505; 15598682; 15611088; 15640525; 15642170; 15643515; 15644318; 15652748; 15659383; 15668138; 15670823; 15710384; 15755723; 15761153; 15766663; 15793564; 15793569; 15809302; 15817453; 15834426; 15843433; 158…
description: ras homolog family member A
database cross reference: Ensembl:ENSG00000067560
database cross reference: HGNC:667
database cross reference: HPRD:01323
database cross reference: MIM:165390
database cross reference: Vega:OTTHUMG00000156838

ATP2A1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ATP2A
alternative term: SERCA1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ATP2A1
full name from nomenclature authority: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
NCBI GeneID: 487
gene map location: 16p12.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005388 (EC: IDA, PMID: 1329967); GO_0005509 (EC: IMP, PMID: 9405806); GO_0005509 (EC: ISS); GO_0005515 (EC: IPI, PMID: 9295312); GO_0005524 (EC: IEA); GO_0005524 (EC: ISS); GO_0005789 (EC: IDA, PMID: 11402072); GO_0005789 (EC: TAS); GO_0005793 (EC: ISS); GO_0006200 (EC: ISS); GO_0006816 (EC: IDA, PMID: 11402072); GO_0006816 (EC: IMP, PMID: 9405806); GO_0006942 (EC: IMP, PMID: 9405806); GO_0007596 (EC: TAS); GO_0008637 (EC: IMP, PMID: 19061639); GO_0016020 (EC: ISS); GO_0016021 (EC: NAS, PMID: 9405806); GO_0016529 (EC: ISS); GO_0016529 (EC: NAS, PMID: 8841193); GO_0031095 (EC: TAS); GO_0031448 (EC: IDA, PMID: 12479237); GO_0031673 (EC: IDA, PMID: 1329967); GO_0031674 (EC: IDA, PMID: 1329967); GO_0032470 (EC: IMP, PMID: 11402072); GO_0032471 (EC: IMP, PMID: 11402072); GO_0033017 (EC: IC, PMID: 8040329); GO_0033017 (EC: TAS, PMID: 11402072); GO_0034220 (EC: TAS); GO_0034704 (EC: IC, PMID: 11402072); GO_0034976 (EC: IMP, PMID: 19061639); GO_0042803 (EC: IPI, PMID: 11402072); GO_0045988 (EC: IMP, PMID: 10914677); GO_0048471 (EC: ISS); GO_0051561 (EC: IMP, PMID: 19061639); GO_0051659 (EC: IMP, PMID: 19061639); GO_0055085 (EC: TAS); GO_0070059 (EC: IMP, PMID: 19061639); GO_0070509 (EC: IMP, PMID: 8040329); GO_0070588 (EC: IDA, PMID: 1329967); GO_0090076 (EC: IDA, PMID: 8841193)
has PubMed association: PMID: 1329967; 1746562; 2842876; 2936465; 8040329; 8729696; 8825625; 8841193; 8889548; 9295312; 9367679; 9405806; 9575189; 9642673; 10551848; 10914677; 11402072; 11438520; 11526231; 12032137; 12477932; 12479237; 12525698; 12692302; 12975374; 14638697; 14702039; 15071553; 15718407; 15767202; 15972723; 16192278; 16410239; 16642550; 16754798; 16933204; 17010426; 17110338; 17728322; 18947188; 18953100; 19061639; 19079260; 19644701; 21145461; 21576492; 21726808; 21890473; 21906983; 21963094; 22505724; 22609207; 22939629; 23911890
description: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
database cross reference: Ensembl:ENSG00000196296
database cross reference: HGNC:811
database cross reference: HPRD:00157
database cross reference: MIM:108730
database cross reference: Vega:OTTHUMG00000131760

BAD
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BBC2
alternative term: BCL2L8
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BAD
full name from nomenclature authority: BCL2-associated agonist of cell death
NCBI GeneID: 572
gene map location: 11q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001836 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10949025); GO_0005543 (EC: IMP); GO_0005739 (EC: IDA); GO_0005741 (EC: IDA); GO_0005741 (EC: TAS); GO_0005829 (EC: IDA); GO_0005829 (EC: TAS); GO_0006007 (EC: IEA); GO_0006915 (EC: IDA, PMID: 19667065); GO_0006915 (EC: TAS, PMID: 7834748); GO_0006919 (EC: ISS); GO_0007173 (EC: TAS); GO_0008289 (EC: IDA, PMID: 19667065); GO_0008543 (EC: TAS); GO_0008625 (EC: IEA); GO_0008630 (EC: IEA); GO_0008656 (EC: IDA, PMID: 18402937); GO_0009749 (EC: IEA); GO_0010508 (EC: TAS, PMID: 18309324); GO_0010918 (EC: ISS); GO_0019050 (EC: IEA); GO_0019221 (EC: IEA); GO_0019901 (EC: IPI, PMID: 17270021); GO_0030346 (EC: IEA); GO_0032024 (EC: ISS); GO_0032355 (EC: IEA); GO_0032570 (EC: IEA); GO_0033133 (EC: ISS); GO_0033574 (EC: IEA); GO_0034201 (EC: IEA); GO_0035774 (EC: IEA); GO_0038095 (EC: TAS); GO_0042493 (EC: IEA); GO_0042542 (EC: IEA); GO_0042593 (EC: ISS); GO_0043065 (EC: IDA, PMID: 9388232); GO_0043065 (EC: IMP, PMID: 17289999); GO_0043065 (EC: TAS); GO_0043200 (EC: IEA); GO_0043280 (EC: IDA, PMID: 18402937); GO_0043422 (EC: IEA); GO_0044342 (EC: ISS); GO_0045087 (EC: TAS); GO_0045471 (EC: IEA); GO_0045579 (EC: IEA); GO_0045582 (EC: IEA); GO_0045862 (EC: IDA, PMID: 18387192); GO_0046031 (EC: ISS); GO_0046034 (EC: ISS); GO_0046902 (EC: IMP); GO_0046931 (EC: IDA, PMID: 19667065); GO_0046982 (EC: IEA); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0050679 (EC: IMP, PMID: 19593445); GO_0051384 (EC: IEA); GO_0051592 (EC: IEA); GO_0060139 (EC: IEA); GO_0060154 (EC: IEA); GO_0071247 (EC: IEA); GO_0071260 (EC: IEP, PMID: 19593445); GO_0071316 (EC: IDA, PMID: 18676776); GO_0071396 (EC: IEA); GO_0071456 (EC: IEP); GO_0090200 (EC: IMP, PMID: 17289999); GO_0097190 (EC: TAS); GO_0097191 (EC: IMP, PMID: 18852119); GO_0097192 (EC: IEA); GO_0097193 (EC: IMP, PMID: 18676776); GO_0097193 (EC: TAS); GO_0097202 (EC: IDA, PMID: 18387192); GO_1900740 (EC: TAS); GO_1901216 (EC: IEA); GO_2000078 (EC: ISS); GO_2001244 (EC: TAS)
has PubMed association: PMID: 7834748; 8929531; 8929532; 9130713; 9305851; 9369453; 9381178; 9388232; 9389483; 9463381; 9651683; 9824152; 9878060; 9973195; 10195903; 10381646; 10407019; 10521512; 10558990; 10579309; 10611223; 10620799; 10811615; 10837486; 10837489; 10880354; 10949025; 10949026; 11077446; 11206074; 11278245; 11410287; 11483855; 11494146; 11500364; 11544290; 11583631; 11689886; 11697890; 11717309; 11739707; 11742726; 11781193; 11839683; 11878929; 11908866; 11994280; 12084714; 12087097; 12115603; 12137781; 12239175; 12376548; 12477932; 12657644; 12754297; 12787561; 12842996; 12897128; 12931191; 12954615; 12965220; 14702039; 14767529; 14967141; 15033904; 15078178; 15131699; 15183529; 15226424; 15231831; 15280438; 15489334; 15574335; 15694340; 15705582; 15721256; 15731037; 15751984; 15767261; 15784622; 15849194; 15901741; 15978696; 15990872; 15998799; 16148027; 16189514; 16297499; 16403219; 16413544; 16445909; 16484005; 16603546; 16697956; 16710454; 16728406; 16767165; 16785131; 16843435; 16847055; 16908594; 16932738; 16949642; 16978419; 17011751; 17110373; 17270021; 17274640; 17287851; 17289999; 17393317; 17404594; 17420275; 17438366; 17446862; 17457084; 17474147; 17499381; 17541305; 17544220; 17557568; 17670745; 17696955; 17696989; 17900801; 17927446; 17979178; 18006502; 18029348; 18165867; 18246127; 18276761; 18309324; 18387192; 18391004; 18402774; 18402937; 18420586; 18449891; 18508762; 18508827; 18568448; 18593990; 18628207; 18636124; 18651163; 18651222; 18676776; 18775810; 18798227; 18832722; 18852119; 18973553; 19168699; 19171933; 19508210; 19587239; 19593445; 19624871; 19641507; 19667065; 19679565; 19730683; 19773546; 19882362; 19895838; 19913121; 20012528; 20043968; 20339252; 20596645; 20618440; 20628086; 20647330; 20691103; 20700721; 20810912; 20855536; 20877624; 20936779; 21076048; 21081150; 21187157; 21302807; 21317286; 21419810; 21444773; 21674599; 21849418; 21900206; 21918885; 21988832; 22011203; 22057915; 22096607; 22172950; 22214866; 22423221; 22464442; 22805310…
description: BCL2-associated agonist of cell death
database cross reference: Ensembl:ENSG00000002330
database cross reference: HGNC:936
database cross reference: HPRD:04409
database cross reference: MIM:603167
database cross reference: Vega:OTTHUMG00000134302

BAG1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BAG-1
alternative term: HAP
alternative term: RAP46
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BAG1
full name from nomenclature authority: BCL2-associated athanogene
NCBI GeneID: 573
NCBI LocusTag: RP11-326F20.2
gene map location: 9p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005057 (EC: TAS, PMID: 8947043); GO_0005515 (EC: IPI, PMID: 19800331); GO_0005634 (EC: IDA); GO_0005737 (EC: IEA); GO_0006915 (EC: IEA); GO_0007166 (EC: TAS, PMID: 8947043); GO_0035556 (EC: TAS, PMID: 8947043); GO_0043066 (EC: TAS, PMID: 8947043); GO_0051087 (EC: IEA); GO_0070389 (EC: IDA, PMID: 12853476)
has PubMed association: PMID: 7834747; 8125298; 8524784; 8692945; 8812483; 8889548; 8947043; 9305631; 9396724; 9565586; 9582267; 9603979; 9642262; 9679980; 9747877; 9774640; 9873016; 10467399; 10477749; 10671488; 10816573; 10967105; 11076863; 11101523; 11222862; 11231577; 11256614; 11257006; 11278763; 11340068; 11520069; 11676916; 11741305; 11994280; 12049201; 12297498; 12402153; 12421809; 12477932; 12724406; 12845674; 12853476; 12874020; 14517289; 14532969; 14680805; 14702039; 14978028; 15075668; 15169918; 15199607; 15297164; 15309313; 15489334; 15489336; 15538384; 15603737; 15707960; 15831476; 15843891; 15986447; 16042572; 16207813; 16292491; 16381901; 16398049; 16457154; 16482527; 17278878; 17549665; 17657847; 17662274; 17693608; 17700523; 17950682; 17954934; 18029348; 18204076; 18388150; 18413740; 18430249; 18523358; 18684711; 18805052; 18822299; 19060904; 19066611; 19151744; 19229298; 19243896; 19293798; 19317853; 19546472; 19595997; 19778524; 19800331; 19881545; 19913121; 20096920; 20156966; 20237496; 20404511; 20409521; 20628086; 20675402; 20819778; 20855536; 20858459; 21036726; 21157029; 21195059; 21522149; 21809033; 21890473; 21986497; 21988832; 22016818; 22179630; 22439756; 22454210; 22863883; 22939115; 22939629; 23000965; 23049684; 23059827; 23108401; 23178238; 23271418; 23322525; 23493285; 23553841; 23708800; 23852223; 24250222; 24318877
description: BCL2-associated athanogene
database cross reference: Ensembl:ENSG00000107262
database cross reference: HGNC:937
database cross reference: HPRD:03292
database cross reference: MIM:601497
database cross reference: Vega:OTTHUMG00000019766

BAX
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BCL2L4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BAX
full name from nomenclature authority: BCL2-associated X protein
NCBI GeneID: 581
gene map location: 19q13.3-q13.4
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001101 (EC: IEA); GO_0001541 (EC: IEA); GO_0001764 (EC: IEA); GO_0001777 (EC: IEA); GO_0001782 (EC: IEA); GO_0001783 (EC: IDA, PMID: 15214043); GO_0001822 (EC: IEA); GO_0001836 (EC: IDA, PMID: 16199525); GO_0001844 (EC: IEA); GO_0001974 (EC: IEA); GO_0002262 (EC: IEA); GO_0002352 (EC: IEA); GO_0002358 (EC: IEA); GO_0002904 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10753914); GO_0005634 (EC: IMP, PMID: 15102863); GO_0005739 (EC: IDA, PMID: 11912183); GO_0005741 (EC: IBA); GO_0005741 (EC: TAS); GO_0005757 (EC: IDA, PMID: 9843949); GO_0005783 (EC: IDA, PMID: 16424160); GO_0005789 (EC: IDA, PMID: 16424160); GO_0005829 (EC: IDA, PMID: 11912183); GO_0005829 (EC: TAS); GO_0006687 (EC: IEA); GO_0006808 (EC: IEA); GO_0006915 (EC: NAS, PMID: 9920818); GO_0006915 (EC: TAS); GO_0006919 (EC: IDA, PMID: 11912183); GO_0006919 (EC: IMP, PMID: 11350920); GO_0006927 (EC: IMP, PMID: 10739008); GO_0007281 (EC: IEA); GO_0008053 (EC: IDA, PMID: 14769861); GO_0008289 (EC: IDA, PMID: 14522999); GO_0008625 (EC: IC, PMID: 16199525); GO_0008630 (EC: IBA); GO_0008635 (EC: IDA, PMID: 15214043); GO_0008637 (EC: IDA, PMID: 9843949); GO_0009566 (EC: IEA); GO_0009636 (EC: IDA, PMID: 16307838); GO_0009651 (EC: IEA); GO_0010248 (EC: IDA, PMID: 9843949); GO_0010332 (EC: IEA); GO_0015267 (EC: IDA, PMID: 9219694); GO_0016032 (EC: IEA); GO_0021854 (EC: IEA); GO_0021987 (EC: IEA); GO_0030264 (EC: IEA); GO_0032091 (EC: IDA, PMID: 9388232); GO_0032461 (EC: IDA, PMID: 19805544); GO_0032469 (EC: TAS, PMID: 18309324); GO_0032471 (EC: IEA); GO_0032976 (EC: IDA, PMID: 9843949); GO_0033137 (EC: IEA); GO_0033599 (EC: IEA); GO_0034644 (EC: IEA); GO_0035234 (EC: IEA); GO_0042475 (EC: IEA); GO_0042802 (EC: IPI, PMID: 10620504); GO_0042803 (EC: IDA, PMID: 16608847); GO_0042803 (EC: IPI, PMID: 9111042); GO_0043065 (EC: IMP, PMID: 17289999); GO_0043496 (EC: IDA, PMID: 9111042); GO_0043497 (EC: IPI, PMID: 9111042); GO_0043524 (EC: IEA); GO_0043525 (EC: IDA, PMID: 15637643); GO_0043653 (EC: IDA, PMID: 12499352); GO_004513…
has PubMed association: PMID: 7566098; 7607685; 7834749; 8358790; 8521816; 8580080; 8760290; 8889548; 8961277; 9020077; 9027312; 9111042; 9130713; 9153240; 9219694; 9372935; 9388232; 9449720; 9463381; 9531611; 9565621; 9742125; 9748162; 9824152; 9843949; 9920818; 9988273; 10200447; 10365962; 10381646; 10437917; 10620504; 10620603; 10620799; 10629050; 10702418; 10716992; 10739008; 10753914; 10772918; 10837489; 10854321; 10908576; 10942389; 11060313; 11106734; 11136736; 11161816; 11175251; 11175336; 11251969; 11259440; 11278245; 11283018; 11350920; 11437653; 11571294; 11574543; 11602639; 11642719; 11742726; 11759059; 11759062; 11782443; 11787859; 11839668; 11839683; 11842081; 11850803; 11850816; 11852106; 11867266; 11869962; 11875499; 11894116; 11899739; 11909872; 11911971; 11912124; 11912183; 11922616; 11929871; 11932420; 11943780; 11949842; 11992551; 11994280; 11997495; 12023951; 12025227; 12032841; 12036888; 12058280; 12070030; 12070120; 12082629; 12137781; 12151395; 12161031; 12165421; 12169275; 12176904; 12189556; 12193163; 12214154; 12215338; 12215842; 12270344; 12359369; 12388688; 12389125; 12393866; 12393884; 12408758; 12419244; 12426317; 12439925; 12445631; 12454021; 12477729; 12477932; 12481899; 12490315; 12496485; 12499352; 12510156; 12575534; 12579342; 12583439; 12592374; 12606781; 12732850; 12737446; 12743423; 12749011; 12767928; 12782632; 12808108; 12816867; 12837286; 12839682; 12853473; 12901880; 12907654; 12917444; 12963997; 12970744; 14522999; 14550297; 14559989; 14596892; 14606101; 14612448; 14612938; 14628086; 14631373; 14634023; 14647416; 14647455; 14661970; 14681224; 14698203; 14704000; 14714449; 14716828; 14719078; 14730312; 14752512; 14766748; 14767525; 14769861; 14963330; 14971737; 14980220; 15024076; 15033690; 15037603; 15073604; 15077116; 15096513; 15102863; 15131699; 15148411; 15149158; 15158440; 15214043; 15231068; 15254227; 15258908; 15262986; 15292938; 15298965; 15302859; 15304079; 15314639; 15322047; 15351796; 15375594; 15375604; 15383280; 15388581; 15459197; 1…
description: BCL2-associated X protein
database cross reference: Ensembl:ENSG00000087088
database cross reference: HGNC:959
database cross reference: HPRD:02498
database cross reference: MIM:600040
database cross reference: Vega:OTTHUMG00000160476

BCHE
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CHE1
alternative term: CHE2
alternative term: E1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BCHE
full name from nomenclature authority: butyrylcholinesterase
NCBI GeneID: 590
gene map location: 3q26.1-q26.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001540 (EC: NAS, PMID: 11569538); GO_0003824 (EC: NAS, PMID: 11569538); GO_0003990 (EC: IBA); GO_0003990 (EC: ISS); GO_0004104 (EC: IDA, PMID: 19452557); GO_0005576 (EC: NAS, PMID: 14718574); GO_0005576 (EC: TAS); GO_0005615 (EC: IBA); GO_0005641 (EC: IEA); GO_0005788 (EC: IBA); GO_0007271 (EC: IBA); GO_0007612 (EC: IEA); GO_0008285 (EC: IEA); GO_0014016 (EC: IEA); GO_0016020 (EC: IEA); GO_0019695 (EC: IBA); GO_0019899 (EC: NAS, PMID: 11569538); GO_0033265 (EC: IEA); GO_0042493 (EC: IEA); GO_0042802 (EC: IPI); GO_0043279 (EC: IEA); GO_0044267 (EC: TAS); GO_0050783 (EC: TAS, PMID: 8622553); GO_0050805 (EC: IEA); GO_0051384 (EC: IEA); GO_0051593 (EC: IEA); GO_0072562 (EC: IDA)
has PubMed association: PMID: 1769657; 1769658; 2318303; 2322535; 2339692; 2915989; 3035536; 3067729; 3115973; 3477799; 3542989; 8063698; 8622553; 8680411; 8930175; 9543549; 9673783; 10529218; 11125748; 11436125; 11569538; 11725818; 11738493; 11749053; 11793025; 11848688; 11849755; 11856322; 11856351; 12003252; 12009429; 12044901; 12074828; 12130740; 12387584; 12417112; 12477932; 12668920; 12687586; 12724618; 12811800; 12869558; 12881446; 12901493; 14622273; 14686935; 14718574; 14735258; 14760718; 15060281; 15111428; 15258737; 15386241; 15449725; 15465921; 15489334; 15519745; 15690550; 15696543; 15731585; 15781196; 15802910; 15834019; 15907830; 16020944; 16105444; 16213467; 16278840; 16288482; 16289064; 16298355; 16335952; 16344560; 16429499; 16504521; 16731619; 16788378; 16801396; 16824336; 16909200; 16962996; 16973370; 17116317; 17192624; 17275003; 17318303; 17335779; 17350607; 17410321; 17503475; 17660298; 17690023; 17698511; 17700357; 17701416; 17768338; 17852836; 17917325; 17923322; 17996334; 18075469; 18076380; 18165570; 18237553; 18290843; 18300943; 18322399; 18334913; 18422653; 18457821; 18550040; 18555211; 18640242; 18778798; 18780301; 19006190; 19010318; 19019080; 19056482; 19156168; 19217865; 19383604; 19452557; 19474452; 19481150; 19578796; 19617863; 19685167; 19713000; 19913121; 19956635; 20056567; 20058037; 20122907; 20143968; 20193849; 20308990; 20356562; 20379614; 20399202; 20445134; 20529763; 20538374; 20628086; 20644562; 20677742; 20807286; 20879632; 20883446; 20886866; 21029050; 21402063; 21454498; 21473860; 21493754; 21530486; 21547979; 21576115; 21862451; 21943158; 22040426; 22157615; 22294139; 22331678; 22402324; 22560633; 22750491; 22778864; 22901043; 22917637; 22922115; 22935510; 23000450; 23022600; 23044488; 23063927; 23092211; 23123771; 23419831; 23466605; 23508960; 23689009; 23782236; 24001779; 24125115
description: butyrylcholinesterase
database cross reference: Ensembl:ENSG00000114200
database cross reference: HGNC:983
database cross reference: HPRD:01519
database cross reference: MIM:177400
database cross reference: Vega:OTTHUMG00000158131

CCND1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BCL1
alternative term: D11S287E
alternative term: PRAD1
alternative term: U21B31
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCND1
full name from nomenclature authority: cyclin D1
NCBI GeneID: 595
gene map location: 11q13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000082 (EC: IDA, PMID: 19412162); GO_0000082 (EC: TAS, PMID: 18483258); GO_0000122 (EC: IDA, PMID: 16569215); GO_0000278 (EC: TAS); GO_0000307 (EC: IDA, PMID: 17420273); GO_0000320 (EC: IEA); GO_0001889 (EC: IEA); GO_0001934 (EC: IDA, PMID: 8114739); GO_0003714 (EC: IDA, PMID: 16569215); GO_0004672 (EC: IEA); GO_0005515 (EC: IPI, PMID: 15232106); GO_0005622 (EC: IDA); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005829 (EC: TAS); GO_0005923 (EC: IEA); GO_0006351 (EC: IEA); GO_0006974 (EC: IDA, PMID: 19412162); GO_0007219 (EC: TAS); GO_0007595 (EC: IEA); GO_0008134 (EC: IPI, PMID: 16569215); GO_0010039 (EC: IEA); GO_0010165 (EC: IEA); GO_0010243 (EC: IEA); GO_0010971 (EC: IDA, PMID: 19124461); GO_0016020 (EC: IEA); GO_0016538 (EC: IEA); GO_0017053 (EC: IDA, PMID: 16569215); GO_0019899 (EC: IPI, PMID: 19412162); GO_0019901 (EC: IPI, PMID: 19124461); GO_0030178 (EC: IEA); GO_0030857 (EC: IEA); GO_0030968 (EC: IEA); GO_0031100 (EC: IEA); GO_0031571 (EC: IDA, PMID: 19412162); GO_0032026 (EC: IEA); GO_0032403 (EC: IEA); GO_0033197 (EC: IEA); GO_0033327 (EC: IEA); GO_0033598 (EC: IEA); GO_0033601 (EC: IEA); GO_0042493 (EC: IEP, PMID: 18291362); GO_0042826 (EC: IPI, PMID: 18417529); GO_0043627 (EC: IEA); GO_0045444 (EC: IEA); GO_0045471 (EC: IEA); GO_0045737 (EC: IDA, PMID: 8114739); GO_0051301 (EC: IEA); GO_0051412 (EC: IEA); GO_0051592 (EC: IEA); GO_0060070 (EC: IEA); GO_0060749 (EC: IEA); GO_0070064 (EC: IDA, PMID: 19124461); GO_0070141 (EC: IDA, PMID: 18483258); GO_0071157 (EC: IDA, PMID: 19124461)
has PubMed association: PMID: 1386335; 1532244; 1535701; 1682919; 1826542; 1827756; 1833066; 1833629; 6610211; 7478582; 7568034; 7665234; 7687458; 7733934; 7739547; 7903056; 7908906; 8058338; 8058751; 8101826; 8114739; 8134134; 8136159; 8159685; 8204893; 8208539; 8259215; 8302605; 8490963; 8643455; 8647086; 8657154; 8662825; 8756624; 8826947; 8867812; 8887674; 8978686; 8999999; 9003781; 9039267; 9050835; 9106657; 9139732; 9150368; 9178893; 9190208; 9228064; 9244350; 9311993; 9372967; 9380698; 9426067; 9626345; 9632134; 9661876; 9736735; 9832502; 9832503; 9837900; 9926939; 10066798; 10202152; 10318892; 10344732; 10353443; 10371345; 10486249; 10491434; 10500095; 10580009; 10581175; 10645009; 10764802; 10766840; 10801854; 10850422; 10908655; 10910956; 10952989; 11042687; 11073968; 11076863; 11126356; 11256614; 11279133; 11311237; 11360184; 11470749; 11593423; 11642719; 11696452; 11698342; 11698641; 11739785; 11739795; 11751903; 11788592; 11793365; 11805292; 11813305; 11815623; 11836555; 11838966; 11860939; 11870667; 11872630; 11884610; 11896626; 11902820; 11923474; 11935308; 11940657; 11948404; 11958128; 11986316; 11992406; 12002755; 12006580; 12007188; 12024041; 12036888; 12036906; 12036934; 12036951; 12048199; 12067972; 12096344; 12097293; 12101670; 12127555; 12138206; 12150453; 12151312; 12164325; 12203362; 12209953; 12231535; 12237776; 12241561; 12364325; 12376514; 12379776; 12383116; 12388769; 12391146; 12394763; 12439750; 12444551; 12455063; 12477932; 12480939; 12515730; 12519773; 12529437; 12539042; 12554669; 12557224; 12569141; 12582032; 12589056; 12594215; 12601350; 12606305; 12607604; 12634633; 12673692; 12676926; 12680219; 12692418; 12694349; 12707028; 12738746; 12743597; 12746453; 12759391; 12761882; 12778072; 12807740; 12808109; 12824903; 12825853; 12867429; 12883688; 12883749; 12894561; 12896908; 12899785; 12914697; 12917336; 12917338; 12921950; 12930597; 12937137; 12955092; 12965081; 12972956; 14530270; 14612904; 14641107; 14645506; 14645576; 14646596; 14657069; 14666635; 14666…
description: cyclin D1
database cross reference: Ensembl:ENSG00000110092
database cross reference: HGNC:1582
database cross reference: HPRD:01346
database cross reference: MIM:168461
database cross reference: Vega:OTTHUMG00000167877

BCL2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: Bcl-2
alternative term: PPP1R50
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BCL2
full name from nomenclature authority: B-cell CLL/lymphoma 2
NCBI GeneID: 596
gene map location: 18q21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 18
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000209 (EC: IDA, PMID: 16717086); GO_0001101 (EC: IEA); GO_0001503 (EC: IEA); GO_0001541 (EC: IEA); GO_0001656 (EC: IEA); GO_0001658 (EC: IEA); GO_0001662 (EC: IEA); GO_0001782 (EC: IEA); GO_0001836 (EC: ISS, PMID: 9843949); GO_0001836 (EC: NAS, PMID: 9027314); GO_0001952 (EC: IEA); GO_0002020 (EC: IDA, PMID: 10620603); GO_0002320 (EC: IEA); GO_0002326 (EC: IEA); GO_0002931 (EC: IEA); GO_0003014 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10837489); GO_0005634 (EC: IDA, PMID: 7546744); GO_0005737 (EC: IDA, PMID: 11530860); GO_0005739 (EC: IDA, PMID: 7896880); GO_0005741 (EC: IDA, PMID: 8402648); GO_0005741 (EC: TAS); GO_0005783 (EC: IDA, PMID: 8402648); GO_0005789 (EC: IEA); GO_0005829 (EC: IEA); GO_0006470 (EC: IEA); GO_0006582 (EC: IEA); GO_0006808 (EC: IEA); GO_0006915 (EC: TAS); GO_0006959 (EC: TAS, PMID: 1908951); GO_0006974 (EC: IMP, PMID: 17875758); GO_0007015 (EC: IEA); GO_0007409 (EC: IEA); GO_0007565 (EC: NAS, PMID: 11530860); GO_0007569 (EC: IEA); GO_0008134 (EC: IEA); GO_0008219 (EC: IDA, PMID: 36599); GO_0008584 (EC: IEA); GO_0008625 (EC: IDA, PMID: 10597216); GO_0008630 (EC: IBA); GO_0008631 (EC: IEA); GO_0009314 (EC: NAS, PMID: 15799693); GO_0009636 (EC: IDA, PMID: 16307838); GO_0009791 (EC: IEA); GO_0010039 (EC: IDA, PMID: 11264898); GO_0010224 (EC: IEA); GO_0010332 (EC: IEA); GO_0010507 (EC: TAS, PMID: 18309324); GO_0010523 (EC: IEA); GO_0010559 (EC: IEA); GO_0014031 (EC: IEA); GO_0014042 (EC: IEA); GO_0014911 (EC: IEA); GO_0015267 (EC: IDA, PMID: 9219694); GO_0016020 (EC: IDA, PMID: 7896880); GO_0016049 (EC: IEA); GO_0016248 (EC: IDA, PMID: 9219694); GO_0016337 (EC: IEA); GO_0018105 (EC: IEA); GO_0018107 (EC: IEA); GO_0021747 (EC: IEA); GO_0022612 (EC: IEA); GO_0022898 (EC: IDA, PMID: 9219694); GO_0030279 (EC: IEA); GO_0030307 (EC: IDA, PMID: 8022822); GO_0030308 (EC: IEA); GO_0030318 (EC: IEA); GO_0030336 (EC: IEA); GO_0030890 (EC: IMP, PMID: 17875758); GO_0031069 (EC: IEA); GO_0031103 (EC: IEA); GO_0031625 (EC: IPI); GO_0031647 (EC: IEA); GO_003196…
has PubMed association: PMID: 36599; 1339299; 1373874; 1453000; 1502141; 1508712; 1908951; 2250705; 2834197; 2875799; 3285301; 3523487; 3924412; 7546744; 7579350; 7593193; 7650367; 7753817; 7772249; 7834748; 7896880; 7929424; 7954800; 8022822; 8050499; 8080725; 8090743; 8183370; 8232588; 8358790; 8402618; 8402648; 8551385; 8668206; 8760290; 8790371; 8910675; 8929532; 8949945; 9027314; 9031086; 9070836; 9109491; 9111042; 9115213; 9119086; 9130713; 9184696; 9219694; 9226175; 9226228; 9305631; 9334338; 9389483; 9395403; 9430630; 9449720; 9463381; 9488477; 9525867; 9561195; 9660918; 9668078; 9727491; 9731710; 9738012; 9765397; 9788433; 9843949; 9852076; 9973195; 10072505; 10075695; 10198631; 10217402; 10329560; 10330179; 10354271; 10417825; 10467396; 10490827; 10506221; 10521466; 10567572; 10597216; 10620603; 10620799; 10622714; 10625696; 10669763; 10677502; 10679027; 10716992; 10807576; 10837489; 10848600; 10871848; 10949025; 11054413; 11060313; 11123279; 11126360; 11158204; 11175251; 11181702; 11206074; 11262395; 11264898; 11278245; 11323417; 11325850; 11326318; 11368354; 11390485; 11406564; 11437653; 11463391; 11463392; 11483855; 11495898; 11513873; 11527400; 11530860; 11546872; 11583631; 11642719; 11684014; 11728179; 11752215; 11759059; 11759062; 11774038; 11776759; 11787859; 11790116; 11804283; 11804688; 11815602; 11832478; 11839683; 11855781; 11856759; 11861644; 11864421; 11867266; 11871856; 11877091; 11877266; 11877309; 11877669; 11877670; 11908736; 11914580; 11929874; 11940482; 11948397; 11949842; 11949843; 11956602; 11959101; 11964319; 11971816; 11983915; 11986946; 11988841; 11994280; 11999565; 12000759; 12011972; 12019168; 12025227; 12031912; 12032828; 12032841; 12036852; 12036886; 12036888; 12039864; 12046064; 12054739; 12054916; 12070027; 12082633; 12086670; 12086875; 12095980; 12095993; 12096338; 12101183; 12112824; 12118096; 12133494; 12133517; 12137781; 12140755; 12151395; 12161031; 12162425; 12165497; 12167335; 12170763; 12171774; 12172977; 12174951; 12186923; 12189556; 1219722…
description: B-cell CLL/lymphoma 2
database cross reference: Ensembl:ENSG00000171791
database cross reference: HGNC:990
database cross reference: HPRD:01045
database cross reference: MIM:151430

BCL2L1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BCL-XL/S
alternative term: BCL2L
alternative term: BCLX
alternative term: BCLXL
alternative term: BCLXS
alternative term: Bcl-X
alternative term: PPP1R52
alternative term: bcl-xL
alternative term: bcl-xS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BCL2L1
full name from nomenclature authority: BCL2-like 1
NCBI GeneID: 598
NCBI LocusTag: RP5-857M17.3
gene map location: 20q11.21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000910 (EC: IMP); GO_0001541 (EC: IEA); GO_0001701 (EC: IEA); GO_0001836 (EC: IDA, PMID: 9843949); GO_0005515 (EC: IPI, PMID: 10837489); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA); GO_0005737 (EC: IDA); GO_0005739 (EC: IDA); GO_0005741 (EC: IDA, PMID: 19767770); GO_0005741 (EC: NAS, PMID: 12667443); GO_0005741 (EC: TAS); GO_0005743 (EC: IEA); GO_0005759 (EC: IEA); GO_0005813 (EC: IDA); GO_0005829 (EC: IEA); GO_0006897 (EC: IEA); GO_0006915 (EC: TAS); GO_0007093 (EC: IMP); GO_0007281 (EC: IEA); GO_0007283 (EC: IEA); GO_0008283 (EC: IEA); GO_0008284 (EC: IEA); GO_0008584 (EC: IEA); GO_0008630 (EC: IEA); GO_0008637 (EC: TAS, PMID: 9393856); GO_0009566 (EC: IEA); GO_0010507 (EC: TAS, PMID: 18309324); GO_0016021 (EC: IEA); GO_0019050 (EC: IDA, PMID: 15231831); GO_0019901 (EC: IPI); GO_0030054 (EC: IEA); GO_0030672 (EC: IEA); GO_0031965 (EC: IEA); GO_0034097 (EC: IDA, PMID: 9184696); GO_0035872 (EC: TAS); GO_0040007 (EC: IEA); GO_0042802 (EC: IPI, PMID: 15131699); GO_0042803 (EC: IBA); GO_0043065 (EC: IEA); GO_0043066 (EC: IDA); GO_0043066 (EC: IMP, PMID: 17289999); GO_0043524 (EC: IEA); GO_0045087 (EC: TAS); GO_0046898 (EC: IEA); GO_0046902 (EC: IDA, PMID: 9843949); GO_0046982 (EC: IBA); GO_0051402 (EC: IEA); GO_0051434 (EC: IPI, PMID: 15901672); GO_0051881 (EC: IDA, PMID: 9843949); GO_0060154 (EC: IEA); GO_0071230 (EC: IEA); GO_0071312 (EC: IEA); GO_0071480 (EC: IEA); GO_0071839 (EC: IEA); GO_0090005 (EC: IDA); GO_0090201 (EC: IC); GO_0090201 (EC: IDA, PMID: 12667443); GO_0097136 (EC: IDA); GO_0097192 (EC: IBA); GO_0097193 (EC: TAS); GO_0097284 (EC: IEA); GO_1900118 (EC: IDA); GO_1902230 (EC: IDA, PMID: 16608847); GO_2000811 (EC: IMP, PMID: 15006356); GO_2001240 (EC: TAS, PMID: 8358789); GO_2001243 (EC: IDA, PMID: 12011449); GO_2001244 (EC: TAS)
has PubMed association: PMID: 7540278; 7644501; 7650367; 7834748; 8358789; 8596636; 8692274; 8929532; 9020082; 9027312; 9027313; 9111042; 9130713; 9153240; 9184696; 9192670; 9305851; 9326610; 9334338; 9372935; 9388232; 9389483; 9393856; 9430630; 9435230; 9488720; 9525867; 9539746; 9660918; 9675101; 9727492; 9731710; 9742125; 9765397; 9824152; 9843949; 9973195; 10049775; 10075695; 10195903; 10198631; 10217402; 10330179; 10365962; 10446169; 10467396; 10467399; 10620799; 10625696; 10679027; 10713718; 10716992; 10737788; 10802717; 10807576; 10837489; 10891504; 10949025; 11044452; 11054413; 11060313; 11077446; 11123279; 11126360; 11175750; 11206074; 11278245; 11279541; 11283018; 11342619; 11423909; 11437653; 11463391; 11463392; 11483855; 11494146; 11574549; 11583631; 11696595; 11714801; 11733517; 11739707; 11742726; 11756417; 11780052; 11788897; 11801602; 11815602; 11832478; 11859372; 11883953; 11911810; 11941452; 11964315; 11965035; 11971963; 11994280; 12000759; 12011449; 12025227; 12046686; 12070027; 12079401; 12108390; 12115603; 12137781; 12161031; 12186923; 12198137; 12204872; 12209955; 12214154; 12244097; 12372300; 12381725; 12387875; 12439925; 12477932; 12510191; 12515824; 12553012; 12579342; 12592339; 12594175; 12637494; 12667443; 12721288; 12738789; 12767928; 12783855; 12810626; 12815463; 12853473; 12855666; 12901880; 12937123; 12963020; 12969962; 14502257; 14520471; 14573608; 14596824; 14625274; 14631373; 14656874; 14656879; 14668940; 14735465; 14739602; 14752512; 14764594; 14960327; 14963330; 14980220; 15006356; 15030396; 15034060; 15077116; 15079071; 15124764; 15131699; 15156398; 15179366; 15231831; 15292226; 15292519; 15323553; 15353804; 15375594; 15385505; 15459189; 15459197; 15477204; 15489334; 15574335; 15625014; 15625897; 15637055; 15638362; 15638369; 15653751; 15657349; 15657350; 15694340; 15694358; 15705582; 15721256; 15722788; 15725478; 15733859; 15767554; 15770735; 15782132; 15827323; 15837790; 15870695; 15901672; 15961228; 16048439; 16052512; 16077903; 16081848; 16085054; 1…
description: BCL2-like 1
database cross reference: Ensembl:ENSG00000171552
database cross reference: HGNC:992
database cross reference: HPRD:02497
database cross reference: MIM:600039
database cross reference: Vega:OTTHUMG00000032192

BDNF
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ANON2
alternative term: BULN2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BDNF
full name from nomenclature authority: brain-derived neurotrophic factor
NCBI GeneID: 627
gene map location: 11p13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001657 (EC: IEA); GO_0001662 (EC: IEA); GO_0001666 (EC: IEA); GO_0002544 (EC: IEA); GO_0005169 (EC: IEA); GO_0005576 (EC: IEA); GO_0005737 (EC: ISS); GO_0006120 (EC: IEA); GO_0007399 (EC: TAS, PMID: 2236018); GO_0007406 (EC: IEA); GO_0007411 (EC: IEA); GO_0007412 (EC: IEA); GO_0007611 (EC: IEA); GO_0007631 (EC: IEA); GO_0008021 (EC: IEA); GO_0008038 (EC: IEA); GO_0008083 (EC: IEA); GO_0009725 (EC: IEA); GO_0014047 (EC: IEA); GO_0014076 (EC: IEA); GO_0016358 (EC: IEA); GO_0019222 (EC: IEA); GO_0021675 (EC: IEA); GO_0033189 (EC: IEA); GO_0042490 (EC: IEA); GO_0043524 (EC: IEA); GO_0045666 (EC: IEA); GO_0045843 (EC: IEA); GO_0046668 (EC: IEA); GO_0048170 (EC: IEA); GO_0048172 (EC: IEA); GO_0048471 (EC: ISS); GO_0048839 (EC: IEA); GO_0051965 (EC: IDA, PMID: 19036963); GO_0055093 (EC: IEA); GO_0060079 (EC: IEA); GO_0072347 (EC: IEA)
has PubMed association: PMID: 1339267; 1645620; 1889806; 1889807; 2025430; 2230938; 2236018; 7703225; 7961712; 8174548; 8527932; 8869564; 9118804; 9312147; 9387865; 9519408; 9580557; 9878821; 9990022; 10391209; 10493752; 10760298; 11152678; 11166915; 11214319; 11244490; 11408619; 11782995; 11836300; 11840487; 11855816; 11923430; 11935372; 12008958; 12130635; 12140770; 12140781; 12161822; 12192623; 12358753; 12359171; 12397373; 12477932; 12480128; 12524161; 12531456; 12553913; 12568867; 12694935; 12719654; 12738784; 12742659; 12753507; 12836135; 12842310; 12851636; 12888803; 12890761; 12900521; 12912764; 12921913; 12951204; 14566559; 14582140; 14623369; 14636373; 14642442; 14673216; 14681916; 14715936; 14730194; 14730195; 14997020; 15084795; 15094483; 15108194; 15115760; 15118353; 15120095; 15177062; 15274036; 15279867; 15336520; 15337270; 15375678; 15384083; 15457498; 15459944; 15489334; 15526143; 15537879; 15541709; 15543516; 15544837; 15547445; 15567073; 15596541; 15626819; 15626824; 15630410; 15635706; 15647480; 15657181; 15657604; 15664176; 15665077; 15666411; 15710474; 15719396; 15726264; 15768049; 15770238; 15772739; 15816823; 15837123; 15838855; 15843069; 15866349; 15896483; 15896496; 15899246; 15900221; 15913870; 15913964; 15918078; 15935057; 15940292; 15940299; 15949651; 15970929; 15987945; 16005437; 16039058; 16043130; 16046000; 16054753; 16056149; 16105728; 16109452; 16139165; 16152572; 16152573; 16166223; 16172806; 16186425; 16222333; 16301096; 16314750; 16343697; 16344533; 16356643; 16388065; 16388901; 16389585; 16391475; 16406671; 16441896; 16442082; 16446138; 16446742; 16458264; 16472361; 16497333; 16513879; 16533563; 16538178; 16541456; 16565926; 16568151; 16581172; 16604191; 16606648; 16623937; 16627933; 16631352; 16633140; 16648150; 16648236; 16649215; 16680163; 16698101; 16707914; 16713371; 16740142; 16741916; 16741941; 16786155; 16787706; 16797081; 16807663; 16818862; 16823800; 16824691; 16846718; 16847693; 16848784; 16854566; 16869232; 16872631; 16876305; 16890377; 168…
description: brain-derived neurotrophic factor
database cross reference: Ensembl:ENSG00000176697
database cross reference: HGNC:1033
database cross reference: HPRD:00214
database cross reference: MIM:113505
database cross reference: Vega:OTTHUMG00000178797

BID
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FP497
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BID
full name from nomenclature authority: BH3 interacting domain death agonist
NCBI GeneID: 637
gene map location: 22q11.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001836 (EC: IDA, PMID: 17052454); GO_0005123 (EC: TAS, PMID: 8918887); GO_0005515 (EC: IPI, PMID: 12624108); GO_0005739 (EC: TAS, PMID: 9727491); GO_0005741 (EC: TAS); GO_0005829 (EC: TAS); GO_0006626 (EC: IEA); GO_0006915 (EC: TAS); GO_0006919 (EC: IEA); GO_0007420 (EC: IEA); GO_0008625 (EC: TAS, PMID: 9727491); GO_0008637 (EC: TAS, PMID: 9727492); GO_0016020 (EC: TAS, PMID: 8918887); GO_0031625 (EC: IEA); GO_0032355 (EC: IEA); GO_0032461 (EC: IDA, PMID: 19074440); GO_0032464 (EC: IDA); GO_0032592 (EC: IEA); GO_0034349 (EC: IEA); GO_0042127 (EC: IEA); GO_0042770 (EC: TAS, PMID: 18309324); GO_0043065 (EC: IMP, PMID: 17289999); GO_0051260 (EC: IEA); GO_0051402 (EC: TAS, PMID: 16167175); GO_0090150 (EC: IDA); GO_0090200 (EC: IGI); GO_0090200 (EC: IMP, PMID: 17289999); GO_0097193 (EC: TAS); GO_1900740 (EC: TAS); GO_1901030 (EC: TAS); GO_1902108 (EC: IEA); GO_2000045 (EC: IEA); GO_2001238 (EC: IMP); GO_2001244 (EC: TAS)
has PubMed association: PMID: 7774948; 7929347; 8918887; 9463381; 9721221; 9727491; 9727492; 9790773; 10089877; 10364179; 10629050; 10950869; 11085743; 11099414; 11114298; 11399776; 11544326; 11583622; 11583631; 11585909; 11741882; 11790791; 11805084; 11832478; 11929871; 11940658; 11971973; 12000759; 12061801; 12097160; 12193163; 12196516; 12404116; 12419244; 12477932; 12598529; 12624108; 12754217; 12766488; 12804595; 12808108; 12871587; 12934063; 14581476; 14583606; 14702039; 14716828; 14769944; 15024076; 15117953; 15123718; 15146197; 15173176; 15231831; 15323553; 15353804; 15461802; 15489334; 15501827; 15520201; 15574335; 15592455; 15615731; 15637055; 15659383; 15692567; 15694340; 15721256; 15772077; 15809076; 16077201; 16167175; 16172118; 16341674; 16344560; 16380381; 16475813; 16485030; 16697956; 16908521; 16964285; 16987815; 17052454; 17200714; 17226776; 17283187; 17289999; 17308307; 17431792; 17488272; 17534194; 17549073; 17635912; 17666167; 17762183; 17765974; 17855051; 18029348; 18089817; 18165867; 18166654; 18173728; 18195012; 18297401; 18309324; 18317451; 18373075; 18469004; 18593990; 18648372; 18665919; 18723680; 18838202; 18925930; 19029793; 19046991; 19052714; 19074440; 19074885; 19219602; 19233849; 19246452; 19381674; 19423537; 19454696; 19640637; 19641510; 19670908; 19711428; 19820711; 19890662; 19913121; 19918914; 19929986; 20140092; 20187936; 20356928; 20379614; 20392206; 20404718; 20453000; 20628086; 20801175; 20802294; 20855536; 20877624; 21041309; 21060336; 21072056; 21113148; 21139048; 21148306; 21178828; 21223573; 21367852; 21382479; 21613222; 21642428; 21751259; 21856753; 21859891; 21900206; 21906983; 22052011; 22115752; 22130162; 22189507; 22213163; 22246181; 22339673; 22354970; 22393005; 22416135; 22464442; 22860893; 22939629; 22964611; 23019260; 23192964; 23333919; 23352961; 23383273; 23418437; 23604079; 23744079; 23824909; 24074954; 24158446
description: BH3 interacting domain death agonist
database cross reference: Ensembl:ENSG00000015475
database cross reference: HGNC:1050
database cross reference: HPRD:03590
database cross reference: MIM:601997
database cross reference: Vega:OTTHUMG00000150087

CXCR5
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BLR1
alternative term: CD185
alternative term: MDR15
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CXCR5
full name from nomenclature authority: chemokine (C-X-C motif) receptor 5
NCBI GeneID: 643
gene map location: 11q23.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004930 (EC: TAS, PMID: 1425907); GO_0005515 (EC: IPI); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 1425907); GO_0006928 (EC: TAS, PMID: 1425907); GO_0006935 (EC: IEA); GO_0006955 (EC: IEA); GO_0007186 (EC: TAS, PMID: 1425907); GO_0016494 (EC: IEA); GO_0032467 (EC: IMP); GO_0042113 (EC: IEA); GO_0048535 (EC: IEA)
has PubMed association: PMID: 1425907; 7639692; 9463416; 9486651; 11688722; 11714765; 12070001; 12171958; 12324654; 12447991; 12477932; 12578791; 12620646; 14618028; 14763921; 15713799; 15780119; 16225771; 16318584; 16344560; 16888899; 17015714; 17018614; 17652619; 17786442; 18528326; 18577758; 18780835; 19074885; 19228923; 19375853; 19536742; 19610059; 19913121; 19955043; 20412587; 20628086; 20809769; 21399635; 21471443; 21642390; 21750724; 21785430; 21833088; 22607768; 22707196; 22840692; 22913878; 22951725; 23128233; 23189125; 23250934; 23739915; 23807677; 24035365; 24138884
description: chemokine (C-X-C motif) receptor 5
database cross reference: HGNC:1060
database cross reference: HPRD:03367
database cross reference: MIM:601613

C2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ARMD14
alternative term: CO2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: C2
full name from nomenclature authority: complement component 2
NCBI GeneID: 717
NCBI LocusTag: DADB-122G4.1
gene map location: 6p21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004252 (EC: IEA); GO_0005576 (EC: TAS); GO_0005615 (EC: TAS, PMID: 8621452); GO_0006956 (EC: TAS); GO_0006958 (EC: IEA); GO_0030449 (EC: TAS); GO_0045087 (EC: TAS)
has PubMed association: PMID: 162484; 978135; 1084023; 1350302; 1531292; 1577763; 1701385; 2091785; 2493504; 2582254; 2949737; 2997031; 3315100; 3546307; 3643061; 6019133; 6149575; 6199794; 6555044; 6922702; 8120386; 8125298; 8175701; 8299689; 8326124; 8621452; 9453398; 9670930; 10072631; 10734221; 10946278; 10946292; 11222683; 11341920; 12477932; 12823772; 12878586; 14702039; 15199963; 15489334; 16335952; 16518403; 16670774; 17482263; 17576744; 18069935; 18174230; 18493315; 18515590; 18541650; 18806293; 18806297; 18936151; 18987644; 19015224; 19117936; 19169232; 19180512; 19197355; 19237749; 19259132; 19336475; 19344414; 19399715; 19423540; 19430225; 19556007; 19661236; 19696172; 19851445; 19913121; 19948975; 20157618; 20205591; 20378180; 20381870; 20385819; 20385826; 20406964; 20417301; 20438785; 20523265; 20628086; 20679960; 20801516; 20888482; 21105107; 21665990; 21764829; 21881993; 22232432; 22273503; 22566634; 22610944; 22705344; 22869612; 23060141; 23233260; 23455636; 23535732; 23577725; 23620142
description: complement component 2
database cross reference: Ensembl:ENSG00000166278
database cross reference: HGNC:1248
database cross reference: HPRD:08939
database cross reference: MIM:613927
database cross reference: Vega:OTTHUMG00000031190

C3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AHUS5
alternative term: ARMD9
alternative term: ASP
alternative term: C3a
alternative term: C3b
alternative term: CPAMD1
alternative term: HEL-S-62p
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: C3
full name from nomenclature authority: complement component 3
NCBI GeneID: 718
gene map location: 19p13.3-p13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001798 (EC: IEA); GO_0001934 (EC: IDA, PMID: 15833747); GO_0001970 (EC: IEA); GO_0004866 (EC: IEA); GO_0005102 (EC: TAS, PMID: 9164946); GO_0005515 (EC: IPI, PMID: 11705926); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA); GO_0005886 (EC: TAS); GO_0006631 (EC: IEA); GO_0006954 (EC: IEA); GO_0006955 (EC: TAS, PMID: 4097977); GO_0006956 (EC: TAS); GO_0006957 (EC: TAS); GO_0006958 (EC: IEA); GO_0007165 (EC: TAS, PMID: 10085065); GO_0007186 (EC: TAS, PMID: 9164946); GO_0010575 (EC: IDA, PMID: 16452172); GO_0010828 (EC: IDA, PMID: 15833747); GO_0010866 (EC: IDA, PMID: 10432298); GO_0010884 (EC: IDA, PMID: 9555951); GO_0030449 (EC: TAS); GO_0031715 (EC: IDA, PMID: 15833747); GO_0045087 (EC: TAS); GO_0045745 (EC: IDA, PMID: 15833747); GO_0045766 (EC: IEA); GO_0050766 (EC: IEA); GO_0050776 (EC: TAS); GO_0070062 (EC: IDA); GO_0072562 (EC: IDA)
has PubMed association: PMID: 162484; 279011; 695691; 1238393; 1323007; 1350678; 1401896; 1531292; 1577777; 1703437; 1717583; 1830068; 1861080; 1976733; 2387584; 2473125; 2579379; 2584723; 2824652; 3052276; 3260670; 3279119; 3421908; 3488995; 3546307; 3871945; 4062888; 4097977; 6175959; 6203109; 6912277; 7512600; 7535292; 7539791; 7590866; 7642209; 7893437; 7911492; 7961791; 8406564; 8416818; 8471312; 8630395; 8648130; 8702752; 8845016; 8943712; 9059512; 9164946; 9291131; 9544576; 9555951; 9596584; 9605165; 9719152; 9988761; 10078261; 10079271; 10085065; 10358196; 10382758; 10432298; 10608878; 10610782; 10622723; 10882776; 10946275; 11058592; 11073102; 11086104; 11342658; 11367533; 11387479; 11513971; 11684127; 11705926; 11773063; 11785295; 11803045; 11813855; 11854358; 11884542; 11896391; 11939578; 11979403; 12006395; 12165538; 12477932; 12511407; 12540846; 12645945; 12679444; 12754519; 12761187; 12816955; 12878586; 12893820; 12942785; 12967641; 14527961; 14563826; 14639503; 14662858; 14702039; 14760718; 15033778; 15090635; 15187133; 15199963; 15241561; 15278436; 15342556; 15381670; 15383607; 15489226; 15590640; 15648851; 15713467; 15713468; 15749882; 15810889; 15833747; 15872081; 16148107; 16148115; 16177781; 16199891; 16263699; 16301317; 16335952; 16339538; 16355111; 16449793; 16452172; 16516157; 16530040; 16570073; 16627066; 16670774; 16809564; 16823297; 16889542; 16893076; 17051150; 17051152; 17051160; 17060630; 17172439; 17322907; 17372315; 17482181; 17498719; 17502296; 17520688; 17634448; 17684013; 17703412; 17762737; 17767156; 17984207; 18039528; 18039777; 18054386; 18061265; 18174230; 18206145; 18247123; 18253759; 18325906; 18356838; 18383369; 18434316; 18456336; 18562232; 18562603; 18566738; 18572187; 18585783; 18596911; 18631248; 18671285; 18682851; 18694577; 18702682; 18755462; 18760301; 18796626; 18802120; 18805911; 18854167; 18936151; 18974840; 19005416; 19015224; 19017934; 19022911; 19028820; 19028829; 19048105; 19112495; 19117936; 19131662; 19164292; 19168221; 19179465; 191…
description: complement component 3
database cross reference: Ensembl:ENSG00000125730
database cross reference: HGNC:1318
database cross reference: HPRD:00400
database cross reference: MIM:120700
database cross reference: Vega:OTTHUMG00000150335

C6
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: C6
full name from nomenclature authority: complement component 6
NCBI GeneID: 729
gene map location: 5p13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001701 (EC: IEA); GO_0001970 (EC: IEA); GO_0005515 (EC: IPI, PMID: 17474147); GO_0005576 (EC: TAS); GO_0005579 (EC: IEA); GO_0006956 (EC: TAS, PMID: 2808363); GO_0006958 (EC: IEA); GO_0019835 (EC: IEA); GO_0030449 (EC: TAS); GO_0045087 (EC: TAS); GO_0045766 (EC: IEA)
has PubMed association: PMID: 1387399; 1672663; 2468158; 2789218; 2808363; 3052276; 3192535; 3764345; 8101442; 8364540; 8512929; 8805625; 9366265; 9472666; 9856498; 10551839; 12477932; 14757862; 15489334; 15845028; 16169070; 16335952; 16344560; 17257682; 17474147; 18842294; 19162005; 19344414; 19423540; 19665237; 19864026; 19913121; 20237496; 20406964; 20438785; 20459687; 20628086; 21704099; 21988832; 22267737; 22288589; 22500023; 23149075; 23750785
description: complement component 6

C7
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: C7
full name from nomenclature authority: complement component 7
NCBI GeneID: 730
gene map location: 5p13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005576 (EC: TAS); GO_0005579 (EC: IEA); GO_0006883 (EC: IEA); GO_0006956 (EC: TAS, PMID: 3335508); GO_0006957 (EC: IEA); GO_0006958 (EC: IEA); GO_0019835 (EC: IEA); GO_0030449 (EC: TAS); GO_0045087 (EC: TAS)
has PubMed association: PMID: 1387399; 1517503; 1672663; 2792129; 3052276; 3335508; 7523157; 7730625; 7814888; 8345200; 8364540; 8814254; 8871666; 8892662; 9218625; 9856499; 10551839; 10882776; 10886241; 11378347; 12477932; 12595902; 14760718; 15383587; 15489334; 15879120; 15889368; 16335952; 17266113; 18029348; 18842294; 19162005; 19179470; 19221116; 19344414; 19419965; 19423540; 19834535; 19864026; 19913121; 19931914; 20237496; 20406964; 20438785; 20628086; 21881993; 22206826; 23943762
description: complement component 7

CA1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CA-I
alternative term: CAB
alternative term: Car1
alternative term: HEL-S-11
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CA1
full name from nomenclature authority: carbonic anhydrase I
NCBI GeneID: 759
gene map location: 8q21.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004089 (EC: IEA); GO_0005829 (EC: TAS); GO_0006730 (EC: IEA); GO_0008270 (EC: IEA); GO_0015701 (EC: TAS); GO_0044281 (EC: TAS)
has PubMed association: PMID: 406674; 804171; 827930; 1602151; 1916821; 2121614; 2511043; 3088232; 3104879; 3124707; 4207120; 4217196; 4625868; 4632246; 6781336; 7574487; 7866410; 9879596; 11392054; 11680594; 12009884; 12477932; 14675565; 15342556; 15489334; 15836783; 15837325; 16870440; 17192395; 17314045; 17464559; 18029348; 19536309; 20624682; 21143847; 21900206; 21988832; 22360420; 22416960; 22619369; 22996014; 23557951; 23720494
description: carbonic anhydrase I
database cross reference: Ensembl:ENSG00000133742
database cross reference: HGNC:1368
database cross reference: HPRD:00265
database cross reference: MIM:114800
database cross reference: Vega:OTTHUMG00000164941

CALM1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CALML2
alternative term: CAMI
alternative term: CPVT4
alternative term: DD132
alternative term: PHKD
alternative term: caM
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CALM1
full name from nomenclature authority: calmodulin 1 (phosphorylase kinase, delta)
NCBI GeneID: 801
gene map location: 14q32.11
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 14
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has PubMed association: PMID: 1332771; 1519061; 1520270; 1544444; 1660262; 1790714; 1872871; 2062825; 2123288; 2161834; 2223880; 2445749; 2455687; 2487274; 2507540; 2853949; 3111527; 3350007; 3472906; 6385987; 6847627; 7490111; 7525583; 7559563; 7593266; 7607248; 7642608; 7836475; 7887964; 7925473; 7947686; 8206911; 8226798; 8312049; 8314583; 8486648; 8573130; 8625412; 8626479; 8639568; 8663089; 8670801; 8756646; 8769426; 8780394; 8824319; 8862395; 8872303; 8900147; 8901523; 9003189; 9009191; 9092566; 9096366; 9115241; 9188503; 9202019; 9278050; 9282777; 9341188; 9362478; 9374536; 9490638; 9512352; 9658102; 9677319; 9681195; 9728925; 9753452; 9774336; 9822657; 9837900; 9923700; 9952395; 10026195; 10026200; 10075657; 10075700; 10088721; 10333484; 10411641; 10416864; 10488094; 10547355; 10625668; 10681496; 10692436; 10747990; 10748158; 10757985; 10816571; 10823944; 10827182; 10852921; 10860555; 10880439; 10893241; 10899953; 11054265; 11072229; 11171103; 11178895; 11248124; 11278607; 11323678; 11395482; 11397791; 11448995; 11457836; 11585916; 11734550; 11736632; 11741295; 11807557; 11811958; 11827172; 11847276; 11953448; 11981030; 11984006; 12006621; 12032157; 12034722; 12051765; 12135876; 12153558; 12202484; 12221128; 12223552; 12358748; 12408866; 12446675; 12475216; 12477932; 12509414; 12556500; 12594225; 12610000; 12626507; 12626508; 12715898; 12724311; 12727204; 12805215; 12808128; 12809501; 12821674; 12901717; 12925680; 14551202; 14594800; 14613930; 14695896; 14960328; 14985437; 15048887; 15087444; 15104175; 15147735; 15161933; 15229223; 15316014; 15494036; 15522886; 15583004; 15632291; 15664518; 15670850; 15746150; 15746172; 15746192; 15806159; 15817490; 15840729; 15851513; 15902271; 15990872; 16013055; 16030015; 16051151; 16051665; 16084495; 16127172; 16154564; 16229872; 16258073; 16299511; 16338416; 16344560; 16359877; 16512683; 16522924; 16613843; 16627785; 16760425; 16799092; 17046994; 17202341; 17314412; 17379601; 17568776; 17569884; 17580302; 17654480; 17696464; 17884685; 17942410…
description: calmodulin 1 (phosphorylase kinase, delta)
database cross reference: Ensembl:ENSG00000198668
database cross reference: HGNC:1442
database cross reference: HPRD:00241
database cross reference: MIM:114180
database cross reference: Vega:OTTHUMG00000171044

CALM2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CAMII
alternative term: PHKD
alternative term: PHKD2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CALM2
full name from nomenclature authority: calmodulin 2 (phosphorylase kinase, delta)
NCBI GeneID: 805
gene map location: 2p21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has PubMed association: PMID: 2223880; 2445749; 3111527; 8076819; 8226798; 8312049; 8314583; 8573130; 8780394; 8862395; 9096366; 9242710; 9278050; 9282777; 9362478; 9658102; 9681195; 9923700; 10075700; 10416864; 10625668; 10692436; 10757985; 10816571; 10823944; 10899953; 11054265; 11072229; 11591728; 11736632; 11741295; 11847276; 11953448; 11981030; 12032157; 12051765; 12153558; 12189141; 12221128; 12477932; 12577052; 14613930; 14702039; 15225611; 15342556; 15632291; 15723066; 16051665; 16127172; 16169070; 16189514; 16229872; 16545345; 17046994; 17189291; 17202341; 17687619; 18370588; 18553937; 19584346; 19913121; 20000738; 20012528; 20198394; 20379146; 20379614; 20628086; 20639865; 20876399; 20956522; 21047202; 21078624; 21139048; 21145461; 21546767; 21565611; 21726808; 21799007; 21890473; 21906983; 21963094; 21987572; 21988832; 22053931; 22323446; 22331908; 22505724; 22633975; 22939629; 23000965; 23349634; 23388215; 23798571
description: calmodulin 2 (phosphorylase kinase, delta)
database cross reference: Ensembl:ENSG00000143933
database cross reference: HGNC:1445
database cross reference: HPRD:00242
database cross reference: MIM:114182
database cross reference: Vega:OTTHUMG00000128850

CAPN2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CANP2
alternative term: CANPL2
alternative term: CANPml
alternative term: mCANP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CAPN2
full name from nomenclature authority: calpain 2, (m/II) large subunit
NCBI GeneID: 824
gene map location: 1q41-q42
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000785 (EC: IEA); GO_0001666 (EC: IEA); GO_0001824 (EC: IEA); GO_0004198 (EC: IBA); GO_0004198 (EC: ISS); GO_0005509 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10639123); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA); GO_0005737 (EC: ISS); GO_0005783 (EC: IDA, PMID: 14559243); GO_0005794 (EC: IDA, PMID: 14559243); GO_0005829 (EC: IDA, PMID: 12150984); GO_0005886 (EC: IDA, PMID: 12150984); GO_0006508 (EC: IBA); GO_0006508 (EC: ISS); GO_0007520 (EC: IEA); GO_0008092 (EC: NAS, PMID: 12150984); GO_0008234 (EC: TAS, PMID: 2209092); GO_0016540 (EC: IEA); GO_0030425 (EC: ISS); GO_0030864 (EC: TAS, PMID: 12150984); GO_0031143 (EC: IDA, PMID: 14559243); GO_0045121 (EC: IDA, PMID: 14559243); GO_0045121 (EC: IDA, Qualifier: colocalizes_with, PMID: 12150984); GO_0046982 (EC: IEA); GO_0051493 (EC: TAS, PMID: 12150984); GO_0051603 (EC: IC, PMID: 12150984); GO_0070062 (EC: IDA, PMID: 19056867); GO_0071230 (EC: ISS); GO_0097038 (EC: IDA, PMID: 14559243)
has PubMed association: PMID: 1067155; 1527057; 2209092; 2539381; 2852952; 3038169; 8561910; 8900201; 8954122; 9213221; 9337844; 9407132; 9562261; 9873017; 10639123; 10666632; 10671558; 10830966; 10944468; 10978167; 11023826; 11387205; 11483505; 11517928; 11673052; 11853546; 12000759; 12070670; 12130691; 12150984; 12477932; 12665801; 12783889; 14559243; 14688278; 14702039; 14976200; 14980313; 14993287; 15302874; 15471877; 15489334; 15590481; 15817486; 15950654; 16310784; 16344560; 16361262; 16436382; 16530191; 16598790; 16652152; 16816119; 17192410; 17261541; 17359359; 17596297; 17643375; 17650508; 17897354; 18032503; 18239623; 18332219; 18340456; 18568448; 19056867; 19074885; 19422794; 19720936; 19752040; 19756344; 19861418; 19913121; 19946123; 20041182; 20070945; 20150423; 20193680; 20379614; 20453000; 20618160; 20628086; 20729206; 20730561; 20924799; 20962236; 21086148; 21117903; 21139048; 21152086; 21185840; 21374734; 21839844; 21890473; 21906983; 21963094; 22064597; 22335024; 22435971; 22623320; 22629380; 22711986; 22745213; 22863883; 22990118; 23000965; 23140395; 23389291; 23466492; 23538341; 23667531; 23733271; 23940116
description: calpain 2, (m/II) large subunit
database cross reference: Ensembl:ENSG00000162909
database cross reference: HGNC:1479
database cross reference: HPRD:00254
database cross reference: MIM:114230
database cross reference: Vega:OTTHUMG00000037376

CASP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ICE
alternative term: IL1BC
alternative term: P45
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CASP1
full name from nomenclature authority: caspase 1, apoptosis-related cysteine peptidase
NCBI GeneID: 834
gene map location: 11q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001666 (EC: IEA); GO_0004197 (EC: IBA); GO_0004197 (EC: TAS); GO_0005515 (EC: IPI, PMID: 11374873); GO_0005576 (EC: IEA); GO_0005737 (EC: IBA); GO_0005829 (EC: TAS); GO_0006508 (EC: IDA, PMID: 12888622); GO_0006915 (EC: TAS, PMID: 7876192); GO_0006919 (EC: TAS, PMID: 10799503); GO_0007165 (EC: TAS, PMID: 1373520); GO_0008656 (EC: TAS, PMID: 10799503); GO_0032496 (EC: IEA); GO_0032611 (EC: IEA); GO_0033198 (EC: IEA); GO_0035872 (EC: TAS); GO_0043123 (EC: IEP, PMID: 12761501); GO_0045087 (EC: TAS); GO_0050717 (EC: IEA); GO_0050718 (EC: IEA); GO_0050727 (EC: IBA); GO_0051882 (EC: IEA); GO_0060081 (EC: IEA); GO_0070269 (EC: IEA); GO_0071260 (EC: IEP, PMID: 19593445); GO_0071310 (EC: IDA, PMID: 19158679); GO_0072557 (EC: IBA); GO_0072557 (EC: ISS); GO_0072558 (EC: IDA, PMID: 12191486); GO_0072559 (EC: IDA, PMID: 15030775); GO_0097169 (EC: IDA, PMID: 19158676); GO_0097194 (EC: IBA)
has PubMed association: PMID: 1321594; 1373520; 1574116; 1919001; 7642516; 7721861; 7797510; 7876192; 8034320; 8035875; 8044845; 8125298; 8861900; 8962078; 8978814; 8999548; 9002959; 9070648; 9115219; 9190289; 9219695; 9250871; 9334240; 9334338; 9435230; 9535906; 9548463; 9593687; 9632733; 9705209; 9705938; 9727491; 9792675; 9804161; 9830039; 9875225; 9894612; 9987822; 9990034; 10069390; 10329646; 10353249; 10438581; 10477277; 10510468; 10660263; 10708425; 10799503; 11085743; 11226410; 11374873; 11390368; 11432859; 11437653; 11438643; 11472070; 11536016; 11684016; 11821383; 11953316; 11967258; 11997061; 12019269; 12096920; 12170183; 12191486; 12215842; 12387869; 12459189; 12459463; 12477932; 12628757; 12692130; 12761501; 12888622; 14584052; 14669344; 15030775; 15039421; 15107016; 15296730; 15326478; 15383541; 15471361; 15489334; 15498465; 15561713; 15749123; 15809717; 16037825; 16087165; 16123779; 16260731; 16286016; 16405550; 16428475; 16575408; 16621994; 16778130; 16780720; 16785446; 16817903; 16903774; 16920334; 17036048; 17173859; 17196042; 17207965; 17303764; 17360653; 17418785; 17477815; 17597823; 17623017; 17703412; 17959595; 18029348; 18209072; 18263705; 18263805; 18304957; 18329368; 18523309; 18550243; 18577712; 18590738; 18799371; 18828051; 18981155; 19013323; 19074885; 19117953; 19141860; 19158676; 19158679; 19258923; 19269008; 19275586; 19382257; 19414860; 19439663; 19573080; 19593445; 19648107; 19737897; 19773279; 19779610; 19825518; 19833722; 19913121; 20038581; 20048342; 20060974; 20170165; 20184726; 20197547; 20402676; 20485444; 20503287; 20628086; 20808838; 20852925; 20855536; 20959405; 21037509; 21048031; 21052690; 21311905; 21320026; 21463955; 21757759; 21792841; 21832064; 21862576; 21862623; 22046355; 22046441; 22195745; 22227487; 22491736; 22537218; 22833538; 22837397; 23021143; 23209292; 23226468; 23236067; 23278288; 23386603; 23508996; 23590971; 23637985; 23703390; 23793845; 23839215; 23884363; 24022484; 24356306
description: caspase 1, apoptosis-related cysteine peptidase
database cross reference: Ensembl:ENSG00000137752
database cross reference: HGNC:1499
database cross reference: HPRD:00977
database cross reference: MIM:147678
database cross reference: Vega:OTTHUMG00000048072

CASP2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CASP-2
alternative term: ICH1
alternative term: NEDD-2
alternative term: NEDD2
alternative term: PPP1R57
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CASP2
full name from nomenclature authority: caspase 2, apoptosis-related cysteine peptidase
NCBI GeneID: 835
gene map location: 7q34-q35
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001554 (EC: IEA); GO_0003407 (EC: IEA); GO_0004197 (EC: IDA, PMID: 10980123); GO_0005515 (EC: IPI, PMID: 11076957); GO_0005634 (EC: TAS, PMID: 18309324); GO_0005737 (EC: IBA); GO_0005739 (EC: IEA); GO_0005829 (EC: TAS); GO_0006915 (EC: NAS, PMID: 11156409); GO_0006977 (EC: IMP); GO_0007420 (EC: IEA); GO_0007568 (EC: IEA); GO_0008630 (EC: IBA); GO_0008630 (EC: TAS, PMID: 18309324); GO_0016020 (EC: IEA); GO_0016485 (EC: IDA, PMID: 9044836); GO_0019899 (EC: ISS, PMID: 11076957); GO_0019904 (EC: IPI, PMID: 9044836); GO_0035234 (EC: IEA); GO_0043065 (EC: IDA, PMID: 10980123); GO_0043281 (EC: TAS); GO_0043525 (EC: IEA); GO_0048011 (EC: TAS); GO_0071260 (EC: IEP, PMID: 19593445); GO_0097153 (EC: IEA); GO_0097190 (EC: TAS, PMID: 18309324); GO_0097192 (EC: IBA); GO_0097194 (EC: TAS, PMID: 18309324); GO_2001235 (EC: IEA)
has PubMed association: PMID: 7789948; 8044845; 8087842; 8780721; 8962078; 8985253; 9044836; 9228018; 9261102; 9560245; 9695946; 9792675; 9847074; 10079193; 10329646; 10791974; 10980123; 11076957; 11156409; 11278287; 11313953; 11350957; 11399776; 11425872; 11823470; 11830582; 11832478; 11972030; 12011445; 12065594; 12107826; 12145703; 12193789; 12477715; 12477932; 12584573; 12598307; 12787561; 12837286; 12853948; 12920126; 14584591; 14623896; 14647455; 14701762; 14702039; 14713958; 14716300; 15073321; 15173176; 15262979; 15297885; 15489334; 15500642; 15511269; 15555560; 15590671; 15735701; 15817479; 15843892; 15882978; 16172118; 16193064; 16227610; 16344560; 16360037; 16387548; 16652156; 16701639; 16777994; 16822901; 16843824; 17079734; 17159900; 17195089; 17627033; 17637755; 17902043; 17945178; 18166155; 18238895; 18309324; 18375382; 18413747; 18418048; 18723680; 18840686; 19074885; 19269008; 19322201; 19347032; 19414860; 19453261; 19573080; 19593445; 19604093; 19715609; 19730412; 19738422; 19773279; 19935698; 20143425; 20158568; 20187765; 20208132; 20402676; 20453000; 20819778; 20855536; 20978129; 21051981; 21332795; 21415862; 21475302; 21726810; 21828056; 21900206; 21903589; 21906983; 21940110; 21988832; 22002103; 22077397; 22174370; 22201672; 22396545; 22486813; 22505724; 22531785; 22825847; 23042294; 23404198; 23469978; 23553630; 23568547; 24250222; 24321384
description: caspase 2, apoptosis-related cysteine peptidase
database cross reference: Ensembl:ENSG00000106144
database cross reference: HGNC:1503
database cross reference: HPRD:02800
database cross reference: MIM:600639
database cross reference: Vega:OTTHUMG00000023641

CASP3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CPP32
alternative term: CPP32B
alternative term: SCA-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CASP3
full name from nomenclature authority: caspase 3, apoptosis-related cysteine peptidase
NCBI GeneID: 836
gene map location: 4q34
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001782 (EC: IEA); GO_0001836 (EC: IEA); GO_0004190 (EC: EXP); GO_0004197 (EC: IDA, PMID: 19240112); GO_0004197 (EC: TAS); GO_0004861 (EC: IEA); GO_0005515 (EC: IPI, PMID: 16501604); GO_0005634 (EC: IDA, PMID: 17167422); GO_0005654 (EC: TAS); GO_0005829 (EC: IDA, PMID: 17167422); GO_0005829 (EC: TAS); GO_0005886 (EC: TAS); GO_0006309 (EC: TAS); GO_0006508 (EC: IDA, PMID: 12888622); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0006974 (EC: IEA); GO_0007507 (EC: IEA); GO_0007605 (EC: IEA); GO_0008233 (EC: IDA, PMID: 17167422); GO_0008625 (EC: IEA); GO_0008631 (EC: IEA); GO_0008635 (EC: TAS); GO_0009411 (EC: IEA); GO_0009611 (EC: IEA); GO_0022617 (EC: TAS); GO_0030182 (EC: IBA); GO_0030198 (EC: TAS); GO_0030216 (EC: IBA); GO_0030218 (EC: IDA, PMID: 17167422); GO_0030218 (EC: TAS, PMID: 18309324); GO_0030220 (EC: TAS, PMID: 18309324); GO_0030889 (EC: IEA); GO_0034349 (EC: IEA); GO_0034612 (EC: TAS, PMID: 10521396); GO_0035329 (EC: TAS); GO_0042981 (EC: TAS); GO_0043029 (EC: IEA); GO_0043065 (EC: TAS); GO_0043066 (EC: IGI, PMID: 9353287); GO_0043281 (EC: TAS); GO_0043525 (EC: IEA); GO_0045165 (EC: IEA); GO_0045736 (EC: IEA); GO_0046007 (EC: IEA); GO_0048011 (EC: TAS); GO_0051402 (EC: IEA); GO_0097153 (EC: IMP, PMID: 10921886); GO_0097190 (EC: TAS, PMID: 10521396); GO_0097192 (EC: IEA); GO_0097193 (EC: TAS); GO_0097194 (EC: IDA, PMID: 8689682); GO_0097194 (EC: IMP, PMID: 11350920); GO_0097200 (EC: IMP, PMID: 17559062)
has PubMed association: PMID: 1067155; 7596430; 7774019; 7983002; 8044845; 8605870; 8626669; 8673606; 8689682; 8696339; 8755496; 8780721; 8804412; 8812467; 8900201; 8943232; 8962078; 8976194; 9021152; 9045680; 9108473; 9115219; 9206994; 9208847; 9219695; 9230442; 9233763; 9235961; 9252332; 9267021; 9278461; 9298992; 9323209; 9326610; 9334214; 9334240; 9334338; 9337844; 9348292; 9351817; 9353287; 9361003; 9367996; 9368003; 9384571; 9395403; 9422780; 9452471; 9525868; 9535906; 9545236; 9548463; 9593687; 9618490; 9624143; 9632733; 9660939; 9671712; 9685336; 9694885; 9705209; 9708895; 9736630; 9751706; 9786869; 9799125; 9811849; 9840926; 9850056; 9857079; 9875225; 9878167; 9894612; 9933635; 9990034; 10022118; 10066732; 10069390; 10082566; 10103059; 10200531; 10205158; 10205159; 10319819; 10364179; 10409750; 10430052; 10432301; 10435619; 10438581; 10454555; 10469173; 10479680; 10490026; 10510468; 10521396; 10556977; 10564664; 10579725; 10602493; 10602513; 10608812; 10611247; 10629060; 10671544; 10672017; 10675528; 10704341; 10708425; 10712510; 10713703; 10734073; 10748026; 10770929; 10777594; 10791974; 10799874; 10821855; 10823823; 10862606; 10896157; 10899937; 10921886; 10926122; 10942389; 10998058; 11002417; 11016947; 11024045; 11042212; 11053413; 11058115; 11076937; 11084335; 11098060; 11106668; 11123279; 11141237; 11149901; 11162250; 11162351; 11170436; 11175261; 11177389; 11222676; 11230124; 11242052; 11248093; 11257230; 11257232; 11261798; 11274152; 11278283; 11278287; 11278424; 11278572; 11278782; 11278797; 11283607; 11313965; 11331419; 11345898; 11350920; 11356849; 11359776; 11387340; 11399776; 11420704; 11423904; 11425872; 11437602; 11438643; 11447297; 11462036; 11470874; 11478781; 11479289; 11500511; 11509621; 11514563; 11517310; 11526478; 11550094; 11551979; 11555640; 11602184; 11675509; 11689006; 11696595; 11741893; 11748221; 11752060; 11752215; 11787859; 11788610; 11795487; 11802788; 11815631; 11825902; 11830582; 11832478; 11840332; 11854437; 11859414; 11866986; 11875078; 11901153;…
description: caspase 3, apoptosis-related cysteine peptidase
database cross reference: Ensembl:ENSG00000164305
database cross reference: HGNC:1504
database cross reference: HPRD:02799
database cross reference: MIM:600636
database cross reference: Vega:OTTHUMG00000133681

CASP6
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MCH2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CASP6
full name from nomenclature authority: caspase 6, apoptosis-related cysteine peptidase
NCBI GeneID: 839
gene map location: 4q25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004197 (EC: IBA); GO_0004197 (EC: TAS); GO_0005515 (EC: IPI, PMID: 12888622); GO_0005654 (EC: TAS); GO_0005829 (EC: IDA, PMID: 17167422); GO_0005829 (EC: TAS); GO_0006508 (EC: IDA, PMID: 12888622); GO_0006915 (EC: IBA); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0008234 (EC: TAS, PMID: 7796396); GO_0030855 (EC: IEP); GO_0042802 (EC: IPI)
has PubMed association: PMID: 7796396; 7983002; 8710882; 8780721; 8812467; 8900201; 8962078; 8978814; 9219695; 9228018; 9298992; 9337844; 9463409; 9593687; 9857079; 9933635; 9990034; 10069390; 10103059; 10205159; 10409650; 10432301; 10438520; 10469173; 10481058; 10655504; 10734073; 10770929; 11016947; 11098060; 11246070; 11262188; 11331782; 11356849; 11387340; 11423904; 11438643; 11463840; 11514563; 11802788; 11832478; 11859414; 11901153; 11953316; 12052891; 12089322; 12145703; 12232792; 12477932; 12888622; 14713958; 15103018; 15200957; 15273717; 15280469; 15321985; 15356202; 15489334; 15500642; 15511269; 15654952; 15735701; 16123779; 16135563; 16169070; 16341674; 16518869; 16948818; 16977583; 17167422; 17337451; 17392160; 18029348; 18155731; 18408014; 18497562; 18723680; 18762957; 18820706; 18946722; 19022247; 19052714; 19219602; 19269008; 19414860; 19573080; 19694615; 19773279; 19897582; 19915487; 20097875; 20332099; 20402676; 20427671; 20437871; 20606168; 20661084; 20682790; 20702410; 20801175; 20855536; 20890311; 21098228; 21111746; 21139048; 21317160; 21621544; 21900206; 21906983; 21918813; 21936563; 21963094; 21988832; 22094081; 22433863; 22505724; 22683611; 22858542; 22891250; 23402898
description: caspase 6, apoptosis-related cysteine peptidase
database cross reference: Ensembl:ENSG00000138794
database cross reference: HGNC:1507
database cross reference: HPRD:03321
database cross reference: MIM:601532
database cross reference: Vega:OTTHUMG00000131914

CASP7
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CASP-7
alternative term: CMH-1
alternative term: ICE-LAP3
alternative term: LICE2
alternative term: MCH3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CASP7
full name from nomenclature authority: caspase 7, apoptosis-related cysteine peptidase
NCBI GeneID: 840
NCBI LocusTag: RP11-211N11.6
gene map location: 10q25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001836 (EC: IEA); GO_0004190 (EC: IEA); GO_0004197 (EC: IBA); GO_0004197 (EC: TAS); GO_0005515 (EC: IPI, PMID: 11084335); GO_0005634 (EC: IDA, PMID: 17167422); GO_0005654 (EC: TAS); GO_0005737 (EC: TAS, PMID: 8576161); GO_0005829 (EC: IDA, PMID: 17167422); GO_0005829 (EC: TAS); GO_0006508 (EC: IDA, PMID: 12888622); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0007507 (EC: IEA); GO_0007568 (EC: IEA); GO_0008234 (EC: TAS, PMID: 8567622); GO_0008635 (EC: TAS); GO_0009411 (EC: IEA); GO_0043525 (EC: IEA); GO_0097153 (EC: IEA); GO_0097193 (EC: TAS); GO_0097194 (EC: IBA)
has PubMed association: PMID: 1056466; 7983002; 8125298; 8521391; 8567622; 8576161; 8631895; 8755496; 8780721; 8812467; 8889548; 8962078; 9070923; 9219695; 9228018; 9230442; 9298992; 9323209; 9325343; 9337844; 9384571; 9525868; 9535906; 9593687; 9607320; 9671712; 9850056; 9875225; 9894612; 9922454; 9990034; 10069390; 10082581; 10103059; 10200531; 10318789; 10469173; 10564664; 10675528; 10731697; 10791974; 10862606; 10998058; 11016947; 11024045; 11058599; 11084335; 11170436; 11257230; 11257231; 11257232; 11278572; 11356849; 11359776; 11387340; 11399776; 11420704; 11423904; 11425872; 11448953; 11514563; 11535131; 11555640; 11752425; 11755217; 11802788; 11815631; 11829465; 11832478; 11859414; 11875078; 11904443; 11943137; 12107159; 12145703; 12181742; 12477932; 12586738; 12665508; 12804035; 12824163; 12888622; 12951057; 12970753; 14512414; 14583630; 14584591; 14623896; 14713958; 15033720; 15200957; 15254227; 15489334; 15500642; 15507451; 15511269; 15580265; 15650747; 15735701; 16123041; 16213496; 16339151; 16344560; 16385451; 16498457; 16918502; 17023557; 17094969; 17167422; 17283187; 17337451; 17504820; 17532763; 17697120; 17880920; 17978580; 18072206; 18086147; 18459962; 18521960; 18596415; 18708163; 18723680; 18785314; 19022247; 19052714; 19058873; 19141860; 19219602; 19241192; 19258326; 19269008; 19323650; 19414860; 19531679; 19573080; 19581639; 19604093; 19605487; 19617626; 19655253; 19655254; 19692467; 19698783; 19738422; 19759058; 19770576; 19773279; 19782763; 19826114; 19913121; 19996278; 20159985; 20379614; 20402676; 20404718; 20453000; 20468060; 20566630; 20567846; 20628086; 20661084; 20800603; 20819778; 20855536; 20950443; 20959405; 21044950; 21142842; 21157428; 21484410; 21555521; 21936563; 22184066; 22441531; 22451931; 22548721; 22561518; 22584050; 22863883; 22986525; 23000965; 23190606; 23383273; 23650375; 23765963; 23979166
description: caspase 7, apoptosis-related cysteine peptidase
database cross reference: Ensembl:ENSG00000165806
database cross reference: HGNC:1508
database cross reference: HPRD:03457
database cross reference: MIM:601761
database cross reference: Vega:OTTHUMG00000019076

CASP8
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ALPS2B
alternative term: CAP4
alternative term: Casp-8
alternative term: FLICE
alternative term: MACH
alternative term: MCH5
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CASP8
full name from nomenclature authority: caspase 8, apoptosis-related cysteine peptidase
NCBI GeneID: 841
gene map location: 2q33-q34
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001525 (EC: IEA); GO_0001841 (EC: IEA); GO_0002020 (EC: IPI); GO_0002224 (EC: TAS); GO_0002756 (EC: TAS); GO_0004197 (EC: IDA, PMID: 19240112); GO_0004197 (EC: TAS); GO_0005164 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10442631); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005739 (EC: IDA); GO_0005741 (EC: TAS); GO_0005815 (EC: IDA); GO_0005829 (EC: IDA, PMID: 17167422); GO_0005829 (EC: TAS); GO_0005856 (EC: TAS, PMID: 10891503); GO_0006508 (EC: IDA, PMID: 12888622); GO_0006915 (EC: IGI, PMID: 17599062); GO_0006915 (EC: IMP); GO_0006915 (EC: TAS); GO_0006919 (EC: TAS); GO_0006921 (EC: TAS); GO_0007507 (EC: IEA); GO_0008233 (EC: IMP, PMID: 17047155); GO_0008234 (EC: TAS, PMID: 8681376); GO_0008625 (EC: IBA); GO_0009409 (EC: IEA); GO_0016032 (EC: IEA); GO_0030101 (EC: TAS, PMID: 18309324); GO_0030225 (EC: TAS, PMID: 18309324); GO_0030690 (EC: IEA); GO_0031264 (EC: IDA, PMID: 11101870); GO_0031265 (EC: IDA, PMID: 11717445); GO_0031625 (EC: IPI, PMID: 15069192); GO_0032025 (EC: IEA); GO_0032355 (EC: IEA); GO_0032496 (EC: IEA); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034612 (EC: IMP, PMID: 10521396); GO_0035666 (EC: TAS); GO_0035872 (EC: TAS); GO_0035877 (EC: IPI, PMID: 11717445); GO_0042110 (EC: TAS, PMID: 18309324); GO_0042113 (EC: TAS, PMID: 18309324); GO_0043005 (EC: IEA); GO_0043123 (EC: IEP, PMID: 12761501); GO_0043123 (EC: IMP, PMID: 12884866); GO_0043124 (EC: IMP, PMID: 17047155); GO_0044297 (EC: IEA); GO_0045087 (EC: TAS); GO_0045121 (EC: IEA); GO_0045471 (EC: IEA); GO_0045651 (EC: IMP, PMID: 17047155); GO_0045862 (EC: IDA, PMID: 18387192); GO_0046677 (EC: IEA); GO_0051291 (EC: IEA); GO_0051603 (EC: IMP, PMID: 10521396); GO_0060715 (EC: TAS, PMID: 18309324); GO_0070243 (EC: IEA); GO_0070423 (EC: TAS); GO_0071260 (EC: IEP, PMID: 19593445); GO_0071407 (EC: IEA); GO_0097153 (EC: IMP); GO_0097190 (EC: IMP, PMID: 11101870); GO_0097190 (EC: TAS); GO_0097191 (EC: IDA); GO_0097193 (EC: TAS); GO_0097194 (EC: IMP); GO_0097…
has PubMed association: PMID: 170210; 3031469; 7983002; 8521391; 8681376; 8681377; 8755496; 8962078; 9006941; 9027312; 9184224; 9208847; 9219695; 9228018; 9271594; 9289491; 9325248; 9326610; 9334338; 9337844; 9380701; 9535906; 9539746; 9560245; 9575181; 9624166; 9632733; 9721089; 9727491; 9727492; 9763668; 9774341; 9792675; 9804161; 9875225; 9878167; 9931493; 9971775; 9990034; 10069390; 10235259; 10329646; 10432301; 10435619; 10438581; 10442631; 10469173; 10493725; 10508784; 10521396; 10616217; 10708425; 10716992; 10734073; 10860845; 10891503; 10894160; 10911620; 10926122; 10964557; 11000244; 11002417; 11016947; 11048727; 11085743; 11098060; 11101867; 11101870; 11102441; 11161814; 11177389; 11181075; 11260720; 11264300; 11340079; 11387340; 11395500; 11406564; 11420686; 11423904; 11431480; 11437602; 11479289; 11514563; 11555640; 11583996; 11683038; 11684016; 11717445; 11733517; 11734564; 11735112; 11741396; 11741985; 11751056; 11751897; 11752160; 11772515; 11788820; 11832478; 11865194; 11877293; 11917123; 11933563; 11940602; 11965497; 11992615; 12010809; 12021264; 12037669; 12041673; 12052891; 12065591; 12095993; 12096338; 12097160; 12107159; 12107169; 12122017; 12131184; 12170765; 12189238; 12191471; 12196516; 12198154; 12215447; 12218097; 12220669; 12232792; 12353035; 12393901; 12404116; 12438416; 12477932; 12496481; 12496482; 12507932; 12527898; 12598529; 12620239; 12646168; 12668660; 12692130; 12700635; 12700660; 12702723; 12707329; 12721308; 12738800; 12748179; 12750393; 12750404; 12753742; 12754217; 12761501; 12765336; 12804595; 12841868; 12884866; 12887920; 12888622; 12911633; 12912912; 12960156; 13679856; 14522966; 14560027; 14584591; 14625033; 14644092; 14644197; 14684825; 14688019; 14701762; 14713958; 14759258; 14970175; 14982875; 14982947; 14991747; 14993214; 15015772; 15024054; 15034549; 15067048; 15069192; 15111130; 15142380; 15159409; 15205454; 15210716; 15254227; 15262979; 15280356; 15289853; 15369772; 15383280; 15388581; 15389560; 15390286; 15473998; 15476874; 15489334; 1549…
description: caspase 8, apoptosis-related cysteine peptidase
database cross reference: Ensembl:ENSG00000064012
database cross reference: HGNC:1509
database cross reference: HPRD:03459
database cross reference: MIM:601763
database cross reference: Vega:OTTHUMG00000132821

CASP9
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APAF-3
alternative term: APAF3
alternative term: ICE-LAP6
alternative term: MCH6
alternative term: PPP1R56
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CASP9
full name from nomenclature authority: caspase 9, apoptosis-related cysteine peptidase
NCBI GeneID: 842
NCBI LocusTag: RP11-265F14.3
gene map location: 1p36.21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004197 (EC: IBA); GO_0005515 (EC: IPI, PMID: 10206961); GO_0005634 (EC: IEA); GO_0005739 (EC: IEA); GO_0005829 (EC: IDA, PMID: 17167422); GO_0005829 (EC: TAS); GO_0006915 (EC: TAS, PMID: 8663294); GO_0006974 (EC: IDA, PMID: 15657060); GO_0007173 (EC: TAS); GO_0007568 (EC: IEA); GO_0008047 (EC: TAS, PMID: 9390557); GO_0008233 (EC: IDA); GO_0008543 (EC: TAS); GO_0008630 (EC: IMP, PMID: 15657060); GO_0008635 (EC: TAS); GO_0017124 (EC: IDA, PMID: 15657060); GO_0019901 (EC: IDA, PMID: 15657060); GO_0030220 (EC: TAS, PMID: 18309324); GO_0032025 (EC: IEA); GO_0032355 (EC: IEA); GO_0032496 (EC: IEA); GO_0034349 (EC: IEA); GO_0034644 (EC: IDA, PMID: 15657060); GO_0038095 (EC: TAS); GO_0042770 (EC: IDA, PMID: 15657060); GO_0042981 (EC: TAS); GO_0043065 (EC: TAS); GO_0043293 (EC: IDA); GO_0043525 (EC: IEA); GO_0045087 (EC: TAS); GO_0046677 (EC: IEA); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0071549 (EC: IEA); GO_0097193 (EC: TAS); GO_2001020 (EC: IMP, PMID: 15657060)
has PubMed association: PMID: 1067155; 7983002; 8663294; 8900201; 8962078; 9323209; 9337844; 9390557; 9488720; 9539746; 9545235; 9651578; 9671712; 9812896; 9837928; 9878060; 9890966; 9922454; 9990849; 10070954; 10085063; 10187815; 10206961; 10329646; 10376594; 10384055; 10438581; 10469173; 10671558; 10708425; 11024045; 11069302; 11076957; 11084335; 11113115; 11230124; 11242052; 11248093; 11350957; 11387340; 11390657; 11393657; 11408476; 11423904; 11462036; 11514563; 11734640; 11801602; 11801603; 11803376; 11832478; 11870543; 11905052; 11919192; 11927604; 11948397; 12021264; 12055227; 12095993; 12096338; 12145703; 12147322; 12372609; 12393263; 12393884; 12404116; 12477932; 12566444; 12586738; 12620238; 12620239; 12637514; 12732844; 12749848; 12782307; 12792650; 12804035; 12914932; 12954616; 14512414; 14523016; 14566819; 14634335; 14684629; 14701803; 14747474; 14982875; 14991812; 14993223; 15200957; 15214043; 15220451; 15254227; 15262985; 15273730; 15280366; 15300255; 15473998; 15485395; 15485396; 15489334; 15500642; 15507451; 15578977; 15629764; 15657060; 15657349; 15674327; 15703181; 15725353; 15735701; 15749826; 15767427; 15811855; 15829969; 15935070; 16038259; 16120388; 16181301; 16242324; 16260615; 16287866; 16300929; 16322207; 16337360; 16339151; 16344560; 16480911; 16497673; 16505307; 16505493; 16511342; 16520893; 16687442; 16689829; 16701639; 16710414; 16716256; 16780893; 16895904; 16936772; 16979168; 17030903; 17071630; 17079734; 17140287; 17167422; 17179183; 17207965; 17285546; 17291493; 17299206; 17379327; 17409234; 17437405; 17466630; 17534194; 17626072; 17653867; 17893147; 17899380; 17967742; 18022362; 18054197; 18083711; 18086147; 18202770; 18297401; 18309324; 18381704; 18415681; 18632964; 18676680; 18723680; 18813792; 18814044; 18840411; 19013323; 19016842; 19052714; 19058789; 19074885; 19081073; 19141860; 19153467; 19159073; 19170196; 19183163; 19219602; 19238172; 19269008; 19275583; 19275584; 19275586; 19275587; 19359048; 19412632; 19414860; 19458171; 19465923; 19493480; 195…
description: caspase 9, apoptosis-related cysteine peptidase
database cross reference: Ensembl:ENSG00000132906
database cross reference: HGNC:1511
database cross reference: HPRD:03756
database cross reference: MIM:602234
database cross reference: Vega:OTTHUMG00000002256

CAT
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CAT
full name from nomenclature authority: catalase
NCBI GeneID: 847
gene map location: 11p13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000302 (EC: IMP, PMID: 16644728); GO_0001657 (EC: IEA); GO_0001666 (EC: IEA); GO_0001822 (EC: IEA); GO_0004046 (EC: IEA); GO_0004096 (EC: IDA, PMID: 16644728); GO_0004096 (EC: TAS); GO_0005102 (EC: IPI); GO_0005758 (EC: IEA); GO_0005764 (EC: IEA); GO_0005777 (EC: IDA, PMID: 18379038); GO_0005778 (EC: ISS); GO_0005782 (EC: TAS); GO_0005783 (EC: IEA); GO_0005794 (EC: IEA); GO_0005829 (EC: IEA); GO_0005886 (EC: IEA); GO_0006144 (EC: TAS); GO_0006195 (EC: TAS); GO_0006641 (EC: IEA); GO_0008203 (EC: IEA); GO_0009060 (EC: IEA); GO_0009650 (EC: IMP, PMID: 16644728); GO_0014068 (EC: IEA); GO_0016209 (EC: IDA, PMID: 10514471); GO_0016684 (EC: ISS); GO_0019899 (EC: IPI, PMID: 16781659); GO_0020027 (EC: IEA); GO_0020037 (EC: IDA, PMID: 10656833); GO_0032088 (EC: IEA); GO_0033197 (EC: IEA); GO_0042697 (EC: IEA); GO_0042744 (EC: IDA, PMID: 18379038); GO_0042803 (EC: IDA, PMID: 10656833); GO_0043066 (EC: IMP, PMID: 16644728); GO_0043231 (EC: IDA); GO_0044281 (EC: TAS); GO_0046872 (EC: IEA); GO_0050661 (EC: IDA, PMID: 10656833); GO_0051092 (EC: IEA); GO_0051262 (EC: IDA, PMID: 10656833); GO_0051289 (EC: IDA); GO_0051781 (EC: IEA); GO_0055086 (EC: TAS); GO_0055093 (EC: IEA); GO_0071363 (EC: IEA)
has PubMed association: PMID: 1551654; 2268310; 2308162; 2991908; 3755525; 3755526; 3944256; 6252821; 6548744; 7829101; 8282800; 8479912; 9818873; 9848047; 10096042; 10488055; 10514471; 10567208; 10567403; 10656833; 10666617; 10960480; 11106583; 11134921; 11182520; 11313354; 11479740; 11728823; 11729237; 11837458; 11907164; 12032677; 12110367; 12165738; 12231449; 12372460; 12447480; 12468545; 12469627; 12477932; 12487379; 12516882; 12603857; 12606529; 12665801; 12730222; 12777400; 12824748; 12838770; 12950161; 13904105; 14580687; 14710363; 14962975; 14975589; 15125229; 15131792; 15133753; 15182856; 15203188; 15472150; 15489334; 15528999; 15556604; 15705913; 15733034; 15735318; 15774926; 15800961; 15870505; 15934434; 15988600; 16026777; 16047490; 16076760; 16098030; 16192345; 16204228; 16236267; 16298864; 16385446; 16387755; 16424062; 16453382; 16467073; 16482509; 16504657; 16523188; 16554811; 16586065; 16600249; 16630078; 16644728; 16729966; 16773213; 16775184; 16781659; 16868544; 16956821; 17005595; 17053817; 17145829; 17171548; 17209132; 17213227; 17264407; 17548672; 17549373; 17566139; 17567676; 17567781; 17577741; 17601350; 17634480; 17646900; 17693525; 17696155; 17850515; 17879952; 17937824; 18048809; 18171680; 18248894; 18312938; 18353692; 18368408; 18379038; 18415766; 18423055; 18469277; 18483329; 18485895; 18606005; 18634817; 18682580; 18781797; 18930811; 18936436; 18949620; 18977241; 19050255; 19064360; 19092850; 19124506; 19170196; 19172437; 19242068; 19254215; 19255063; 19274593; 19336475; 19341793; 19373626; 19399816; 19409565; 19424819; 19479899; 19497990; 19505917; 19538885; 19584075; 19615732; 19622717; 19625176; 19688952; 19692168; 19705749; 19731237; 19787204; 19855359; 19863340; 19874574; 19896490; 19897513; 19897742; 19902075; 19913121; 19929244; 19949914; 20020532; 20049130; 20078877; 20082261; 20097730; 20105444; 20109103; 20110814; 20178365; 20194081; 20301895; 20416077; 20444272; 20485444; 20494887; 20613769; 20628086; 20643115; 20649881; 20727719; 20732340; 20851292…
description: catalase

CAV1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BSCL3
alternative term: CGL3
alternative term: MSTP085
alternative term: PPH3
alternative term: VIP21
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CAV1
full name from nomenclature authority: caveolin 1, caveolae protein, 22kDa
NCBI GeneID: 857
gene map location: 7q31.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: ISS); GO_0000139 (EC: IDA, PMID: 11294831); GO_0000139 (EC: TAS); GO_0000165 (EC: IEA); GO_0000188 (EC: ISS); GO_0001525 (EC: IEA); GO_0001570 (EC: ISS); GO_0001666 (EC: ISS); GO_0001937 (EC: ISS); GO_0001960 (EC: IEA); GO_0002080 (EC: IEA); GO_0002931 (EC: IEA); GO_0003057 (EC: IEA); GO_0005102 (EC: IPI, PMID: 16890161); GO_0005113 (EC: NAS, PMID: 11278759); GO_0005198 (EC: IDA, PMID: 11865038); GO_0005515 (EC: IPI, PMID: 11075810); GO_0005622 (EC: IDA, PMID: 15703204); GO_0005768 (EC: IDA); GO_0005783 (EC: IDA, PMID: 11294831); GO_0005811 (EC: TAS); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0005887 (EC: IEA); GO_0005901 (EC: IDA, PMID: 15219854); GO_0005901 (EC: NAS, PMID: 15657086); GO_0005929 (EC: IEA); GO_0005938 (EC: IEA); GO_0006641 (EC: ISS); GO_0006816 (EC: ISS); GO_0006874 (EC: ISS); GO_0006940 (EC: ISS); GO_0007519 (EC: ISS); GO_0007595 (EC: IEA); GO_0007596 (EC: TAS); GO_0008104 (EC: ISS); GO_0009267 (EC: IEP, PMID: 15657086); GO_0010524 (EC: ISS, PMID: 19052258); GO_0015485 (EC: TAS, PMID: 11294831); GO_0016032 (EC: IEA); GO_0016050 (EC: IDA, PMID: 12743374); GO_0016323 (EC: IDA, PMID: 16904002); GO_0016324 (EC: IDA, PMID: 16904002); GO_0016504 (EC: ISS); GO_0019217 (EC: ISS); GO_0019899 (EC: IPI); GO_0019915 (EC: ISS); GO_0030193 (EC: IMP, PMID: 17848177); GO_0030301 (EC: TAS, PMID: 11294831); GO_0030514 (EC: IDA, PMID: 15657086); GO_0030666 (EC: TAS); GO_0030857 (EC: ISS); GO_0030879 (EC: ISS); GO_0031295 (EC: IDA, PMID: 17287217); GO_0031397 (EC: IMP); GO_0031410 (EC: IDA, PMID: 19931615); GO_0032091 (EC: IDA, PMID: 16890161); GO_0032507 (EC: ISS); GO_0032570 (EC: IDA, PMID: 12388746); GO_0032947 (EC: TAS, PMID: 19052258); GO_0033137 (EC: IDA, PMID: 18081315); GO_0033138 (EC: IDA, PMID: 18081315); GO_0033484 (EC: ISS); GO_0042310 (EC: IEA); GO_0042524 (EC: IEA); GO_0042632 (EC: ISS); GO_0042632 (EC: TAS, PMID: 11294831); GO_0043234 (EC: IEA); GO_0043409 (EC: ISS); GO_0043627 (EC: IDA, PMID: 12388746); GO_0044281 (EC: TAS); GO_004…
has PubMed association: PMID: 1294831; 1360410; 8058322; 8619474; 8621645; 8632005; 8910295; 8910575; 9110174; 9188442; 9252391; 9361015; 9374534; 9380697; 9553108; 9580552; 9647788; 9662443; 9685399; 9741627; 9801158; 9837809; 9867838; 10066366; 10085129; 10086342; 10087206; 10090765; 10212252; 10218480; 10598578; 10637311; 10675563; 10781589; 10921915; 10980191; 10988071; 11039464; 11075810; 11076863; 11078729; 11102446; 11112773; 11114180; 11238032; 11256614; 11278309; 11278759; 11294831; 11339822; 11425855; 11432874; 11451957; 11498016; 11546661; 11563969; 11563984; 11707266; 11724572; 11748236; 11751885; 11805080; 11845324; 11865038; 11866528; 11915322; 11920460; 11956154; 11980479; 12011038; 12122055; 12138116; 12147258; 12176037; 12185081; 12186899; 12235142; 12354760; 12359771; 12368209; 12372346; 12388423; 12388746; 12401329; 12414512; 12414992; 12429840; 12477932; 12507501; 12529448; 12562842; 12606314; 12633858; 12648214; 12690205; 12694195; 12711000; 12716887; 12730243; 12732636; 12737162; 12743374; 12753742; 12810205; 12813462; 12816877; 12852865; 12888893; 14576164; 14593097; 14612902; 14645548; 14660607; 14665433; 14675200; 14706341; 14707126; 14719121; 14729661; 14963033; 14981899; 15003536; 15064242; 15069532; 15182174; 15190056; 15201341; 15205342; 15219854; 15230350; 15234566; 15234575; 15240128; 15242332; 15263006; 15274335; 15314095; 15334058; 15353589; 15375584; 15458387; 15466865; 15466889; 15485671; 15485672; 15489334; 15489336; 15496150; 15498565; 15504729; 15531587; 15539149; 15590415; 15592455; 15592498; 15657086; 15665033; 15691837; 15703204; 15722199; 15769846; 15782218; 15811424; 15817451; 15948133; 15951569; 15958730; 15968725; 15969750; 16107720; 16202996; 16225848; 16244790; 16251425; 16263077; 16324201; 16328005; 16332692; 16338968; 16344560; 16381901; 16405917; 16407214; 16443388; 16480767; 16501093; 16541313; 16601146; 16601841; 16608879; 16616146; 16617096; 16713605; 16722822; 16723714; 16790997; 16799092; 16807357; 16820915; 16822931; 16850311; 1685724…
description: caveolin 1, caveolae protein, 22kDa
database cross reference: Ensembl:ENSG00000105974
database cross reference: HGNC:1527
database cross reference: HPRD:03028
database cross reference: MIM:601047
database cross reference: Vega:OTTHUMG00000023413

CBS
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HIP4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CBS
full name from nomenclature authority: cystathionine-beta-synthase
NCBI GeneID: 875
gene map location: 21q22.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 21
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000096 (EC: TAS); GO_0001958 (EC: IEA); GO_0001974 (EC: IEA); GO_0004122 (EC: IDA, PMID: 18776696); GO_0004122 (EC: TAS); GO_0005515 (EC: IPI, PMID: 17087506); GO_0005634 (EC: IDA, PMID: 17087506); GO_0005829 (EC: IDA, PMID: 16780588); GO_0005829 (EC: TAS); GO_0006535 (EC: IEA); GO_0006563 (EC: IDA, PMID: 19010420); GO_0006565 (EC: IDA, PMID: 18776696); GO_0006801 (EC: IEA); GO_0019343 (EC: IEA); GO_0019346 (EC: TAS); GO_0019448 (EC: IDA, PMID: 15520012); GO_0019899 (EC: IPI, PMID: 17087506); GO_0020037 (EC: IDA, PMID: 7929220); GO_0020037 (EC: IMP, PMID: 18776696); GO_0021587 (EC: IEA); GO_0030170 (EC: IDA, PMID: 18776696); GO_0030554 (EC: IEA); GO_0030823 (EC: IEA); GO_0031625 (EC: IPI, PMID: 17087506); GO_0034641 (EC: TAS); GO_0042802 (EC: IPI, PMID: 16189514); GO_0042803 (EC: IDA, PMID: 11483494); GO_0043066 (EC: IEA); GO_0043418 (EC: IDA, PMID: 18776696); GO_0043506 (EC: IEA); GO_0044281 (EC: TAS); GO_0046872 (EC: IEA); GO_0050667 (EC: IDA, PMID: 19010420); GO_0050880 (EC: IEA); GO_0051593 (EC: IEA); GO_0060135 (EC: IEA); GO_0060351 (EC: IEA); GO_0070814 (EC: IDA, PMID: 15520012); GO_0070814 (EC: ISS); GO_0071456 (EC: IEA); GO_0072341 (EC: IDA)
has PubMed association: PMID: 404147; 681363; 840498; 1301198; 2894761; 7506602; 7564249; 7598711; 7611293; 7635485; 7762555; 7849717; 7903580; 7929220; 7967489; 7981678; 8022826; 8353501; 8528202; 8755636; 8803779; 8990018; 9156316; 9266356; 9361025; 9383285; 9466992; 9590298; 9790750; 9889017; 10215408; 10338090; 10408774; 10434301; 10462600; 10791559; 10830953; 11013450; 11074524; 11149614; 11173483; 11204591; 11292330; 11310576; 11341749; 11359213; 11359462; 11434706; 11457468; 11483494; 11528503; 11575217; 11672761; 11748855; 11758232; 11872884; 12007221; 12015064; 12020105; 12082592; 12124992; 12154064; 12173932; 12180146; 12186157; 12228232; 12269827; 12379655; 12393509; 12413583; 12427542; 12439143; 12477932; 12529702; 12642343; 12649066; 12725044; 12815602; 12855221; 12889841; 14670973; 14977639; 15009965; 15082224; 15228193; 15354395; 15365998; 15489334; 15503105; 15520012; 15544339; 15554031; 15719048; 15748616; 15755387; 15772012; 15889417; 15922487; 15972722; 15975077; 16007597; 16013960; 16115349; 16189514; 16196087; 16205833; 16259797; 16274669; 16328059; 16363792; 16375773; 16422253; 16470595; 16479318; 16505479; 16541333; 16601865; 16709328; 16780588; 16791140; 16792904; 16941496; 16953589; 17035141; 17087506; 17119116; 17160942; 17311259; 17311260; 17319270; 17327360; 17352495; 17436311; 17540596; 17548676; 17553479; 17601350; 17621169; 17686644; 17726616; 17891500; 17956124; 17993766; 18029348; 18060852; 18203168; 18278872; 18398434; 18427977; 18447718; 18454451; 18614746; 18620331; 18622257; 18635682; 18636124; 18676680; 18708589; 18776696; 18781797; 18785313; 18792976; 18799873; 18818748; 18830263; 18839533; 18936436; 18950795; 18977241; 18977990; 18988749; 18992148; 19010420; 19019082; 19019335; 19019492; 19048631; 19064578; 19074437; 19112534; 19161160; 19166826; 19170196; 19238444; 19267073; 19370759; 19424622; 19429038; 19447967; 19493349; 19527514; 19531479; 19559392; 19593657; 19625176; 19657138; 19657388; 19683694; 19692168; 19722721; 19729796; 19737740; 1990643…
description: cystathionine-beta-synthase
database cross reference: Ensembl:ENSG00000160200
database cross reference: HGNC:1550
database cross reference: HPRD:01994
database cross reference: MIM:613381
database cross reference: Vega:OTTHUMG00000086834

CCNA2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CCN1
alternative term: CCNA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCNA2
full name from nomenclature authority: cyclin A2
NCBI GeneID: 890
gene map location: 4q27
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000079 (EC: IEA); GO_0000086 (EC: TAS); GO_0000278 (EC: TAS); GO_0001939 (EC: IEA); GO_0001940 (EC: IEA); GO_0005515 (EC: IPI); GO_0005634 (EC: IDA, PMID: 16109376); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA); GO_0007067 (EC: IEA); GO_0007095 (EC: TAS, PMID: 1312467); GO_0007265 (EC: IEP, PMID: 9054499); GO_0010389 (EC: IEA); GO_0019901 (EC: IEA); GO_0031100 (EC: IEA); GO_0032355 (EC: IEA); GO_0033762 (EC: IEA); GO_0045893 (EC: IEA); GO_0048146 (EC: IEA)
has PubMed association: PMID: 1312467; 1387877; 1532458; 1675006; 1830372; 1962755; 1967822; 7553852; 7630397; 7969176; 8024548; 8202514; 8230483; 8253383; 8423786; 8463339; 8475101; 8502485; 8626527; 8626584; 8647086; 8662825; 8684460; 8756328; 8756624; 8798463; 9020058; 9053846; 9054499; 9190208; 9199321; 9244350; 9311993; 9380407; 9566895; 9632134; 9660939; 9660973; 9716181; 9724724; 9820826; 9858587; 9885575; 9889196; 10339564; 10373534; 10486249; 10525536; 10540350; 10559858; 10581175; 10673397; 10679238; 10766737; 10864927; 10871850; 10884347; 10924145; 11113184; 11237594; 11238922; 11259605; 11310559; 11377199; 11598016; 11698641; 11884610; 11896577; 11907280; 11931757; 11940657; 11980909; 11983168; 12006580; 12044161; 12244298; 12439743; 12444551; 12477932; 12501191; 12601350; 12673206; 12676926; 12742823; 12853968; 12857729; 12941338; 12947099; 14579410; 14645522; 14646596; 14656438; 14695896; 14747563; 14749377; 14985333; 14993212; 15050687; 15187102; 15189033; 15199159; 15239650; 15306814; 15355997; 15455144; 15469821; 15489334; 15557281; 15558010; 15601848; 15647383; 15649124; 15649889; 15652749; 15671017; 15674323; 15782160; 15800615; 15800651; 15815621; 15828833; 15890360; 16009130; 16109376; 16123593; 16290148; 16327805; 16344560; 16398674; 16407256; 16540140; 16575904; 16670718; 16708383; 16774918; 16823179; 17001081; 17013808; 17043677; 17208191; 17254966; 17255290; 17316413; 17359356; 17361108; 17445807; 17495531; 17593077; 17636382; 17679094; 17698606; 17868400; 17917837; 18184650; 18246796; 18368381; 18391017; 18471975; 18485873; 18490441; 18572908; 18604603; 18635963; 18667424; 18668132; 18676680; 18829481; 19056339; 19098431; 19170196; 19176011; 19363140; 19483727; 19596857; 19614764; 19615732; 19625176; 19631451; 19671680; 19684852; 19692168; 19703905; 19738611; 19773423; 19822658; 19826003; 19858290; 19864233; 19901524; 20126974; 20133761; 20160477; 20193482; 20360068; 20453000; 20660152; 20733051; 20800603; 20857402; 21046779; 21078875; 21139048; 21145461; 21148318…
description: cyclin A2
database cross reference: Ensembl:ENSG00000145386
database cross reference: HGNC:1578
database cross reference: HPRD:00453
database cross reference: MIM:123835
database cross reference: Vega:OTTHUMG00000133072

CCNB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CCNB
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCNB1
full name from nomenclature authority: cyclin B1
NCBI GeneID: 891
gene map location: 5q12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000079 (EC: IEA); GO_0000082 (EC: TAS); GO_0000086 (EC: TAS); GO_0000278 (EC: TAS); GO_0000922 (EC: IDA, PMID: 18195732); GO_0000942 (EC: IDA, PMID: 18195732); GO_0001556 (EC: IEA); GO_0001701 (EC: IEA); GO_0001933 (EC: IEA); GO_0005113 (EC: IPI, PMID: 11331587); GO_0005515 (EC: IPI, PMID: 10373560); GO_0005634 (EC: IDA, PMID: 11331587); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA); GO_0005813 (EC: IDA, PMID: 12524548); GO_0005829 (EC: TAS); GO_0006461 (EC: IEA); GO_0006468 (EC: IEA); GO_0007077 (EC: TAS); GO_0007080 (EC: IMP, PMID: 18195732); GO_0007283 (EC: IEA); GO_0009612 (EC: IEA); GO_0010629 (EC: IEA); GO_0016020 (EC: IEA); GO_0016301 (EC: IEA); GO_0019901 (EC: IPI, PMID: 12524548); GO_0031145 (EC: TAS); GO_0031442 (EC: IEA); GO_0033129 (EC: IEA); GO_0042246 (EC: IEA); GO_0042493 (EC: IEA); GO_0043148 (EC: IMP, PMID: 18195732); GO_0045931 (EC: IMP, PMID: 18195732); GO_0046680 (EC: IEA); GO_0048565 (EC: IEA); GO_0051437 (EC: TAS); GO_0051439 (EC: TAS); GO_0051726 (EC: TAS); GO_0051987 (EC: IMP, PMID: 18195732); GO_0055015 (EC: IEA); GO_0060045 (EC: IEA); GO_0060623 (EC: IEA); GO_0071174 (EC: IMP, PMID: 18195732); GO_0071283 (EC: IEA); GO_0071398 (EC: IEA); GO_0071407 (EC: IEA); GO_0071456 (EC: IEA)
has PubMed association: PMID: 1384126; 1386342; 1387877; 1717476; 1828290; 1836978; 2570636; 7474080; 7474100; 7494303; 7666531; 7737117; 7769006; 7799941; 7843284; 7876309; 7903056; 8070405; 8101826; 8397206; 8397207; 8402895; 8463339; 8475101; 8524869; 8662825; 8756624; 8889548; 9001210; 9053846; 9094673; 9244350; 9247342; 9315635; 9499405; 9515786; 9520381; 9560267; 9679058; 9813064; 9885575; 9891079; 9926943; 10339564; 10362260; 10373560; 10395539; 10421840; 10581175; 10716937; 10793135; 10799291; 10864927; 10958988; 10973963; 10995390; 11113184; 11238118; 11242082; 11259605; 11260656; 11278247; 11285280; 11310559; 11331587; 11444800; 11531413; 11559705; 11562349; 11572993; 11598127; 11642719; 11691994; 11732576; 11751633; 11779217; 11809526; 11836499; 11878934; 11960377; 12009577; 12054478; 12068134; 12097298; 12115375; 12124778; 12200597; 12379461; 12397081; 12424202; 12447691; 12468530; 12477932; 12483522; 12515609; 12524548; 12586340; 12612082; 12676926; 12684677; 12738867; 12775724; 12791267; 12839990; 12865421; 14645578; 14701726; 14760118; 14993212; 15016823; 15024056; 15181148; 15215233; 15256223; 15265780; 15489334; 15541388; 15623561; 15635413; 15654331; 15710382; 15749827; 15767402; 15790566; 15916961; 15931389; 15989971; 16009132; 16082198; 16109376; 16142332; 16159883; 16221667; 16226712; 16237118; 16273239; 16275333; 16322753; 16407259; 16474839; 16478538; 16479161; 16557593; 16614707; 16751065; 16784539; 16799550; 16880739; 16921029; 17098733; 17167975; 17242184; 17242210; 17274640; 17327911; 17359284; 17359356; 17360335; 17373649; 17386261; 17388661; 17389604; 17408621; 17431037; 17445807; 17466630; 17472438; 17495531; 17495533; 17513602; 17533373; 17586317; 17598982; 17655707; 17668170; 17679094; 17850284; 17881737; 18048386; 18059335; 18195732; 18281511; 18337751; 18353325; 18372919; 18408012; 18414058; 18445273; 18471975; 18491248; 18591933; 18593994; 18652313; 18671143; 18692784; 18799590; 18820706; 19028417; 19134343; 19162005; 19275580; 19275586; 19293801; 1934478…
description: cyclin B1
database cross reference: Ensembl:ENSG00000134057
database cross reference: HGNC:1579
database cross reference: HPRD:00454
database cross reference: MIM:123836
database cross reference: Vega:OTTHUMG00000097817

CCNE1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CCNE
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCNE1
full name from nomenclature authority: cyclin E1
NCBI GeneID: 898
gene map location: 19q12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000079 (EC: IEA); GO_0000082 (EC: NAS, PMID: 8207080); GO_0000082 (EC: TAS); GO_0000083 (EC: TAS); GO_0000278 (EC: TAS); GO_0000307 (EC: IEA); GO_0003713 (EC: NAS, PMID: 15572661); GO_0005515 (EC: IPI, PMID: 10330164); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005829 (EC: TAS); GO_0006270 (EC: IEA); GO_0006468 (EC: IMP, PMID: 10500095); GO_0016055 (EC: IEA); GO_0016301 (EC: IEA); GO_0016538 (EC: IEA); GO_0019901 (EC: IEA); GO_0030521 (EC: NAS, PMID: 15572661); GO_0045893 (EC: NAS, PMID: 15572661); GO_0050681 (EC: NAS, PMID: 15572661); GO_0051301 (EC: IEA)
has PubMed association: PMID: 1388095; 1388288; 1833066; 1833068; 7629134; 7698009; 7739542; 7799941; 8207080; 8230483; 8253383; 8617791; 8618861; 8647086; 8649818; 8662825; 8756624; 8769642; 8833152; 8861947; 8867812; 8891332; 8978686; 9012818; 9053846; 9139732; 9153308; 9190208; 9192873; 9192874; 9218599; 9223324; 9311993; 9380407; 9453249; 9472014; 9525916; 9545286; 9632134; 9660939; 9716181; 9731206; 9819444; 9840927; 9840943; 9885575; 9886493; 9891079; 10202152; 10330164; 10339564; 10359664; 10393546; 10454565; 10486249; 10499591; 10499802; 10500095; 10581175; 10593981; 10751146; 10790373; 10827081; 10851086; 10908655; 10953010; 10995386; 10995387; 11085541; 11132966; 11175348; 11221854; 11237742; 11259605; 11477082; 11533444; 11565033; 11565034; 11733001; 11838966; 11877298; 11884622; 11907280; 11919196; 11940657; 12096339; 12096344; 12101670; 12114499; 12133429; 12444551; 12477932; 12529437; 12533700; 12553912; 12601350; 12607005; 12628165; 12647795; 12676926; 12729791; 12777997; 12778072; 12800980; 12824885; 12839982; 12857729; 13678583; 14536078; 14612403; 14645251; 14701826; 14719078; 14739463; 14965268; 14985333; 14999283; 15004009; 15004027; 15007381; 15024056; 15060836; 15178429; 15191351; 15197178; 15343382; 15364936; 15467469; 15469821; 15489334; 15514162; 15555599; 15557281; 15557791; 15572661; 15611651; 15660127; 15665273; 15670215; 15708847; 15709169; 15800651; 15800668; 15980150; 15980415; 16109376; 16124066; 16191374; 16223725; 16289656; 16322693; 16338364; 16344560; 16391523; 16504183; 16538501; 16582606; 16609025; 16627785; 16740753; 16761619; 16765349; 16799991; 16818231; 16823179; 16912169; 17192413; 17218276; 17254966; 17254967; 17293600; 17298674; 17325036; 17360482; 17361108; 17409409; 17431037; 17434132; 17525332; 17646408; 17661632; 17664332; 17726548; 17822621; 17970072; 18029348; 18047954; 18174243; 18208561; 18276582; 18281541; 18301453; 18344087; 18381935; 18455747; 18507837; 18508766; 18559665; 18607847; 18651214; 18799628; 18799789; 18851830; 18959818; 18…
description: cyclin E1
database cross reference: Ensembl:ENSG00000105173
database cross reference: HGNC:1589
database cross reference: HPRD:00455
database cross reference: MIM:123837
database cross reference: Vega:OTTHUMG00000177626

CD3D
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD3-DELTA
alternative term: IMD19
alternative term: T3D
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CD3D
full name from nomenclature authority: CD3d molecule, delta (CD3-TCR complex)
NCBI GeneID: 915
gene map location: 11q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003713 (EC: IDA, PMID: 2017177); GO_0004888 (EC: IC, PMID: 9485181); GO_0005737 (EC: NAS, PMID: 1831653); GO_0005886 (EC: TAS); GO_0007166 (EC: IC, PMID: 9485181); GO_0016021 (EC: IEA); GO_0030217 (EC: IDA, PMID: 2017177); GO_0031295 (EC: TAS); GO_0042101 (EC: IDA, PMID: 8176201); GO_0042101 (EC: NAS, PMID: 9485181); GO_0042105 (EC: IEA); GO_0045059 (EC: ISS); GO_0045944 (EC: IDA, PMID: 2017177); GO_0046982 (EC: IPI, PMID: 9485181); GO_0050776 (EC: TAS); GO_0050852 (EC: TAS)
has PubMed association: PMID: 1372642; 1385321; 1826255; 1831653; 1832084; 1979339; 2017177; 2111780; 2138083; 2540970; 2826124; 2859526; 2939461; 3478717; 3488209; 6095101; 7495730; 7506554; 7517794; 7539755; 7719941; 7774645; 8020575; 8125527; 8145026; 8176201; 8278814; 8621641; 8809126; 9045614; 9263011; 9485181; 9510190; 9582308; 9743208; 10722370; 11048639; 11827988; 12215456; 12410792; 12477932; 12522270; 12604782; 14602880; 15028279; 15144186; 15331598; 15489334; 15489916; 15534202; 15546002; 15592455; 15778375; 16094384; 16407162; 16412509; 16777597; 16822850; 16888097; 17001685; 17023417; 17176095; 17502376; 17632570; 17652306; 17872946; 17923503; 17928336; 18473783; 18541215; 18803280; 18808677; 19056690; 19222422; 19724882; 19726522; 19759518; 19942855; 20012528; 20179761; 20237496; 20478055; 20511557; 20594957; 20660709; 20824090; 21669053; 21669059; 21670311; 21926461; 21984702; 22103833; 22401598; 22505724; 22911005; 23336327
description: CD3d molecule, delta (CD3-TCR complex)
database cross reference: Ensembl:ENSG00000167286
database cross reference: HGNC:1673
database cross reference: HPRD:01730
database cross reference: MIM:186790
database cross reference: Vega:OTTHUMG00000166970

CD3E
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IMD18
alternative term: T3E
alternative term: TCRE
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CD3E
full name from nomenclature authority: CD3e molecule, epsilon (CD3-TCR complex)
NCBI GeneID: 916
gene map location: 11q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001772 (EC: IEA); GO_0002669 (EC: IEA); GO_0004888 (EC: NAS, PMID: 9485181); GO_0005057 (EC: TAS, PMID: 1370449); GO_0005515 (EC: IPI, PMID: 11855827); GO_0005886 (EC: IDA, PMID: 11390434); GO_0005886 (EC: TAS); GO_0005887 (EC: NAS, PMID: 9485181); GO_0006461 (EC: NAS, PMID: 9886373); GO_0007166 (EC: NAS, PMID: 12110186); GO_0007169 (EC: TAS, PMID: 8530500); GO_0007172 (EC: TAS, PMID: 8490660); GO_0007186 (EC: TAS, PMID: 8530500); GO_0007584 (EC: IEA); GO_0009897 (EC: IDA, PMID: 11390434); GO_0017124 (EC: IPI, PMID: 12110186); GO_0019901 (EC: NAS, PMID: 12110186); GO_0030159 (EC: NAS, PMID: 9886373); GO_0031295 (EC: TAS); GO_0032729 (EC: IEA); GO_0032753 (EC: IEA); GO_0035556 (EC: TAS, PMID: 1370449); GO_0042101 (EC: IDA, PMID: 8176201); GO_0042101 (EC: NAS, PMID: 9485181); GO_0042102 (EC: IMP, PMID: 12110186); GO_0042105 (EC: IEA); GO_0042110 (EC: NAS, PMID: 12110186); GO_0042608 (EC: NAS, PMID: 11186279); GO_0042981 (EC: NAS, PMID: 12567487); GO_0045060 (EC: IEA); GO_0045086 (EC: IEA); GO_0045879 (EC: IEA); GO_0046641 (EC: IEA); GO_0046982 (EC: IPI, PMID: 9485181); GO_0050731 (EC: IEA); GO_0050776 (EC: TAS); GO_0050850 (EC: IEA); GO_0050852 (EC: TAS); GO_0097190 (EC: IEA)
has PubMed association: PMID: 1370449; 1385321; 1387664; 1671006; 1832084; 1979339; 2111780; 2138083; 2859526; 3012357; 3267235; 3478717; 7499176; 7500045; 7506554; 7514106; 7517794; 7539755; 7541024; 7699329; 7761456; 7774645; 8125527; 8145026; 8176201; 8366117; 8490660; 8530500; 8621646; 8626450; 8809126; 8906806; 8920877; 9045614; 9120393; 9263011; 9312149; 9378960; 9485181; 9510190; 9582308; 9687533; 9698567; 9743208; 9780176; 9886373; 10373416; 10722370; 11048639; 11115514; 11186279; 11349123; 11390434; 11439187; 11689561; 11827988; 11855827; 12110186; 12410792; 12477932; 12499387; 12522270; 12567487; 12626537; 12734335; 12812314; 14523017; 14757743; 15123239; 15144186; 15342556; 15489334; 15489916; 15534202; 15546002; 15592455; 16094384; 16308105; 16412509; 16461343; 16777597; 17001685; 17023417; 17176095; 17213291; 17507663; 17630354; 17632570; 17652306; 17668204; 17928336; 18473783; 18504423; 18541215; 18555270; 18555888; 18667496; 18808677; 19190244; 19616027; 19724882; 19726522; 19759518; 19913121; 20012528; 20179761; 20237496; 20478055; 20594957; 20628086; 20824090; 21203507; 21669053; 21669059; 21980389; 22401598; 22505724; 22911005; 23166358; 23216707
description: CD3e molecule, epsilon (CD3-TCR complex)
database cross reference: Ensembl:ENSG00000198851
database cross reference: HGNC:1674
database cross reference: HPRD:08923
database cross reference: MIM:186830
database cross reference: Vega:OTTHUMG00000166968

CD3G
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD3-GAMMA
alternative term: IMD17
alternative term: T3G
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CD3G
full name from nomenclature authority: CD3g molecule, gamma (CD3-TCR complex)
NCBI GeneID: 917
gene map location: 11q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004888 (EC: IMP, PMID: 12794121); GO_0005886 (EC: TAS); GO_0005887 (EC: NAS, PMID: 9485181); GO_0006461 (EC: NAS, PMID: 12794121); GO_0007163 (EC: IMP, PMID: 12407027); GO_0007166 (EC: IMP, PMID: 12407027); GO_0015031 (EC: IMP, PMID: 12794121); GO_0030159 (EC: NAS, PMID: 12794121); GO_0031295 (EC: TAS); GO_0038096 (EC: TAS); GO_0042101 (EC: NAS, PMID: 9485181); GO_0042105 (EC: IEA); GO_0042110 (EC: NAS, PMID: 12407027); GO_0042608 (EC: NAS, PMID: 11186279); GO_0045087 (EC: TAS); GO_0046982 (EC: IPI, PMID: 9485181); GO_0050776 (EC: TAS); GO_0050852 (EC: TAS); GO_0070228 (EC: IMP, PMID: 12407027)
has PubMed association: PMID: 1385321; 1387664; 1535555; 1635567; 1709425; 1826255; 1832084; 1979339; 2111780; 2138083; 2139676; 2540970; 2547833; 2826124; 2944745; 3112151; 3478717; 7506554; 7517794; 7533164; 7539755; 7774645; 8125298; 8125527; 8145026; 8636209; 8809126; 9045614; 9263011; 9485181; 9510190; 9582308; 9743208; 10722370; 11048639; 11186279; 11298321; 11827988; 12374807; 12407027; 12410792; 12477932; 12794121; 15459203; 15489334; 15489916; 15638726; 15778375; 15879122; 16094384; 16344560; 16777597; 16888097; 16888650; 16916653; 17001685; 17023417; 17176095; 17632570; 17652306; 17822534; 17923503; 17928336; 18051367; 18473783; 18541215; 18808677; 18815285; 19056690; 19536290; 19724882; 19726522; 19759518; 19860678; 19898481; 20012528; 20179761; 20237496; 20478055; 20511557; 20594957; 20660709; 20824090; 21669053; 21669059; 21670311; 21764047; 21984702; 22401598; 22482414; 22505724; 22731821; 22911005; 23336327; 23348211; 23590417
description: CD3g molecule, gamma (CD3-TCR complex)
database cross reference: HGNC:1675
database cross reference: HPRD:07037
database cross reference: MIM:186740

CD247
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD3-ZETA
alternative term: CD3H
alternative term: CD3Q
alternative term: CD3Z
alternative term: T3Z
alternative term: TCRZ
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CD247
full name from nomenclature authority: CD247 molecule
NCBI GeneID: 919
NCBI LocusTag: RP11-104L21.1
gene map location: 1q24.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004888 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10704231); GO_0005737 (EC: IDA, PMID: 11390434); GO_0005886 (EC: IDA, PMID: 11390434); GO_0005886 (EC: TAS); GO_0016021 (EC: IEA); GO_0016032 (EC: TAS); GO_0031295 (EC: TAS); GO_0038096 (EC: TAS); GO_0042101 (EC: IDA, PMID: 8176201); GO_0042105 (EC: IEA); GO_0042802 (EC: IPI, PMID: 17055436); GO_0042803 (EC: NAS, PMID: 12110186); GO_0045087 (EC: TAS); GO_0050690 (EC: TAS); GO_0050776 (EC: TAS); GO_0050852 (EC: TAS)
has PubMed association: PMID: 1385158; 1385321; 1390434; 1454062; 1530920; 1532817; 1717577; 2111780; 2138083; 2138330; 2145165; 2845582; 2974162; 3478717; 3785426; 7514106; 7517794; 7526385; 7528772; 7589084; 7629168; 7680960; 7737297; 7842742; 8125298; 8176201; 8366117; 8409430; 8417118; 8621646; 8626561; 8656061; 8675217; 8760790; 8809126; 8906806; 8977276; 9036949; 9045614; 9047237; 9172452; 9368621; 9448136; 9484780; 9485181; 9510190; 9575182; 9625766; 9677202; 9687533; 9743208; 9880255; 10224289; 10424441; 10449770; 10704231; 10722370; 10799879; 11048639; 11349123; 11353765; 11390434; 11463741; 11525746; 11572860; 11714771; 11827988; 11851345; 11891219; 11916964; 11920499; 11950832; 12100036; 12110186; 12165490; 12176041; 12202152; 12356870; 12420108; 12421992; 12477932; 12522270; 12587826; 12731048; 12734410; 12755691; 12847689; 12902492; 12928398; 14523017; 14526327; 14550268; 14672952; 14715568; 14757743; 14967045; 15084271; 15144186; 15186530; 15274412; 15323357; 15489334; 15489916; 15592455; 15641485; 15659558; 15743765; 15749888; 15879101; 15922712; 16049493; 16094384; 16337488; 16393980; 16454711; 16461343; 16616055; 16672702; 16710414; 17001685; 17054067; 17055436; 17134238; 17134755; 17176095; 17255353; 17464179; 17652306; 17951997; 17997796; 18051367; 18174230; 18178846; 18207249; 18215426; 18438604; 18463433; 18505733; 18714041; 18721908; 18787188; 19064610; 19082633; 19090773; 19201859; 19229850; 19259799; 19422667; 19536175; 19664385; 19710135; 19898481; 20032419; 20118245; 20179761; 20190752; 20237496; 20383147; 20453842; 20637659; 20723304; 21383967; 21474487; 21669053; 21669059; 21750679; 21779181; 21988832; 22004975; 22221142; 22292024; 22294642; 22345473; 22401598; 22505724; 22536368; 22551306; 22798681; 22844345; 22911005; 23057733; 23228155; 23525753; 23861880; 23916875
description: CD247 molecule
database cross reference: Ensembl:ENSG00000198821
database cross reference: HGNC:1677
database cross reference: HPRD:01729
database cross reference: MIM:186780
database cross reference: Vega:OTTHUMG00000034593

CD4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD4mut
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CD4
full name from nomenclature authority: CD4 molecule
NCBI GeneID: 920
gene map location: 12p13.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001816 (EC: IEA); GO_0001948 (EC: IPI, PMID: 10922058); GO_0004872 (EC: TAS, PMID: 10413516); GO_0004888 (EC: TAS, PMID: 10358157); GO_0005201 (EC: NAS, PMID: 12444132); GO_0005515 (EC: IPI, PMID: 11113139); GO_0005769 (EC: TAS); GO_0005788 (EC: IEA); GO_0005789 (EC: TAS); GO_0005886 (EC: IDA, PMID: 11390434); GO_0005886 (EC: TAS); GO_0006948 (EC: IDA, PMID: 9166430); GO_0006955 (EC: NAS, PMID: 8512039); GO_0007155 (EC: IEA); GO_0007165 (EC: TAS, PMID: 10358157); GO_0007166 (EC: TAS, PMID: 9780207); GO_0007167 (EC: TAS, PMID: 10358157); GO_0007169 (EC: NAS, PMID: 8512039); GO_0008270 (EC: IDA, PMID: 9668045); GO_0009897 (EC: IDA, PMID: 17213291); GO_0015026 (EC: NAS, PMID: 8512039); GO_0016021 (EC: IEA); GO_0016032 (EC: TAS); GO_0019899 (EC: IPI, PMID: 19333378); GO_0019901 (EC: IPI, PMID: 7486703); GO_0030217 (EC: IDA, PMID: 1533274); GO_0030260 (EC: TAS); GO_0031295 (EC: TAS); GO_0032507 (EC: IDA, PMID: 15128768); GO_0042101 (EC: NAS, PMID: 8512039); GO_0042289 (EC: NAS, PMID: 8512039); GO_0042803 (EC: IDA, PMID: 12444132); GO_0045058 (EC: IDA, PMID: 9551897); GO_0045086 (EC: NAS, PMID: 1901411); GO_0045087 (EC: TAS); GO_0045121 (EC: IEA); GO_0045234 (EC: IDA, PMID: 15128768); GO_0045860 (EC: IDA, PMID: 2118992); GO_0050690 (EC: TAS); GO_0050731 (EC: IEA); GO_0050829 (EC: IEA); GO_0050850 (EC: IEA); GO_0050852 (EC: TAS); GO_0050863 (EC: IDA, PMID: 1533274)
has PubMed association: PMID: 153; 200; 237459; 1279195; 1280382; 1281202; 1310988; 1348943; 1352879; 1354681; 1354808; 1356673; 1370558; 1370739; 1373203; 1373549; 1374095; 1376134; 1376135; 1378510; 1380099; 1380260; 1381201; 1381203; 1381399; 1382339; 1388715; 1402655; 1425921; 1433512; 1438278; 1457205; 1457207; 1465431; 1472279; 1489581; 1491632; 1493050; 1500858; 1501286; 1501294; 1503822; 1512692; 1520872; 1527858; 1533274; 1535086; 1535787; 1537337; 1543562; 1546447; 1548744; 1548763; 1548769; 1549584; 1551875; 1563094; 1565858; 1567578; 1569213; 1588493; 1592430; 1599754; 1602552; 1605591; 1614536; 1618861; 1622897; 1627247; 1636088; 1639820; 1674549; 1677023; 1678778; 1685857; 1687500; 1690236; 1690832; 1691226; 1691563; 1693676; 1696539; 1697332; 1698804; 1698911; 1698964; 1701030; 1701782; 1702163; 1702842; 1703212; 1706342; 1708753; 1709701; 1710248; 1711033; 1711118; 1713252; 1713692; 1717587; 1717717; 1720590; 1720627; 1720631; 1721822; 1722676; 1724568; 1727475; 1727486; 1727487; 1727497; 1730924; 1732513; 1736938; 1738091; 1742075; 1757107; 1763044; 1810199; 1832782; 1834739; 1845049; 1851800; 1870202; 1870209; 1871120; 1888898; 1889086; 1896455; 1899141; 1901411; 1910691; 1918997; 1931229; 1931230; 1959561; 1967269; 1967280; 1970124; 1970444; 1971526; 1977427; 1978941; 1979339; 1979910; 1983967; 1984054; 1985197; 1985202; 1991970; 1995942; 2006155; 2007979; 2014052; 2015114; 2018763; 2040625; 2040664; 2045792; 2059359; 2062847; 2068099; 2076345; 2078013; 2078408; 2078409; 2082620; 2103853; 2104682; 2107024; 2109100; 2111957; 2115689; 2118992; 2125484; 2136376; 2171457; 2182910; 2187500; 2190096; 2190604; 2190605; 2198840; 2212945; 2214026; 2243375; 2247146; 2251501; 2261984; 2324685; 2325207; 2335819; 2339113; 2341717; 2363051; 2364018; 2374593; 2402498; 2431105; 2431482; 2432599; 2436231; 2437327; 2438696; 2441727; 2441877; 2446880; 2453925; 2461565; 2462895; 2468713; 2475780; 2479005; 2482055; 2523711; 2536098; 2537355; 2538505; 2538547; 2541915; 2543930; 2545918; 25496…
description: CD4 molecule
database cross reference: Ensembl:ENSG00000010610
database cross reference: HGNC:1678
database cross reference: HPRD:01740
database cross reference: MIM:186940
database cross reference: Vega:OTTHUMG00000168514

CD14
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CD14
full name from nomenclature authority: CD14 molecule
NCBI GeneID: 929
gene map location: 5q31.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001530 (EC: IDA, PMID: 12594207); GO_0001847 (EC: TAS, PMID: 2402637); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0005515 (EC: IPI); GO_0005576 (EC: TAS); GO_0005615 (EC: IEA); GO_0005886 (EC: TAS); GO_0006909 (EC: TAS, PMID: 9548256); GO_0006915 (EC: TAS, PMID: 9548256); GO_0006954 (EC: IEA); GO_0007166 (EC: TAS, PMID: 8798531); GO_0007249 (EC: TAS); GO_0009408 (EC: IEA); GO_0009986 (EC: IEA); GO_0010008 (EC: TAS); GO_0016019 (EC: TAS, PMID: 8798531); GO_0031225 (EC: IEA); GO_0032026 (EC: IEA); GO_0032760 (EC: IDA, PMID: 12594207); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034612 (EC: IEA); GO_0035666 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0045087 (EC: TAS); GO_0045121 (EC: IEA); GO_0045471 (EC: IEA); GO_0045807 (EC: IEA); GO_0050715 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070891 (EC: IDA, PMID: 12594207); GO_0071222 (EC: IDA, PMID: 12594207); GO_0071223 (EC: IDA, PMID: 12594207)
has PubMed association: PMID: 2402637; 2448876; 2453848; 2462937; 2472171; 2779588; 3385210; 7583357; 8798531; 9142045; 9548256; 9562334; 9655682; 9665271; 10395652; 10575214; 11062291; 11076863; 11083760; 11145656; 11199329; 11257272; 11282774; 11343243; 11489942; 11732288; 11745332; 11779220; 11810121; 11825494; 11841490; 11843056; 11854210; 11876746; 11932927; 11935032; 11985523; 12006789; 12011764; 12067299; 12075251; 12082592; 12101079; 12103253; 12106839; 12117913; 12126249; 12140663; 12171914; 12174084; 12185442; 12196527; 12207338; 12324469; 12404174; 12410798; 12414752; 12417309; 12438323; 12450609; 12477932; 12492251; 12566518; 12580907; 12594207; 12624278; 12663765; 12679473; 12700637; 12731067; 12754215; 12756848; 12757265; 12825176; 12832426; 12853157; 12885845; 12897754; 12911501; 12938192; 12940436; 12942028; 12960274; 14500479; 14508193; 14510720; 14517492; 14517520; 14587643; 14617510; 14624155; 14648231; 14672339; 14673018; 14706103; 14720421; 14739370; 14996480; 15034063; 15039096; 15069085; 15080833; 15081257; 15116260; 15120158; 15132789; 15143473; 15164100; 15166925; 15175649; 15190267; 15207785; 15257175; 15269840; 15273551; 15292769; 15342556; 15356557; 15358661; 15369724; 15373760; 15378299; 15489334; 15489336; 15491315; 15516360; 15520404; 15558232; 15591473; 15599151; 15602630; 15619435; 15640605; 15647432; 15655821; 15670766; 15686783; 15714129; 15741437; 15753758; 15764151; 15777548; 15778383; 15842262; 15854776; 15867866; 15879416; 15932345; 15940135; 15946916; 15966209; 15975149; 16038043; 16046876; 16051275; 16061600; 16085746; 16101942; 16109674; 16137548; 16142747; 16148556; 16159630; 16165702; 16174094; 16174099; 16194368; 16239565; 16246938; 16266379; 16273620; 16273622; 16275943; 16283111; 16290232; 16292464; 16331574; 16335952; 16337421; 16344560; 16368002; 16381901; 16385250; 16386288; 16387800; 16409569; 16427140; 16433727; 16437636; 16443672; 16444757; 16446545; 16467036; 16473828; 16492974; 16509825; 16512634; 16520888; 16538169; 16552356; 16611358…
description: CD14 molecule

CD33
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SIGLEC-3
alternative term: SIGLEC3
alternative term: p67
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CD33
full name from nomenclature authority: CD33 molecule
NCBI GeneID: 945
gene map location: 19q13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004872 (EC: TAS, PMID: 10611343); GO_0005515 (EC: IPI, PMID: 10206955); GO_0005886 (EC: TAS, PMID: 3139766); GO_0005887 (EC: TAS, PMID: 3139766); GO_0007155 (EC: IEA); GO_0007165 (EC: TAS, PMID: 10611343); GO_0007267 (EC: TAS, PMID: 10611343); GO_0008285 (EC: TAS, PMID: 10611343); GO_0009897 (EC: IDA)
has PubMed association: PMID: 1696442; 3139766; 7505004; 7718872; 8454872; 8702538; 9465907; 10206955; 10556798; 10611343; 11320212; 11774609; 11943481; 11964282; 11970770; 12063025; 12144127; 12477932; 15342556; 15388576; 15454492; 15489334; 15611322; 15676214; 16380601; 17662271; 18051367; 18062779; 18085638; 18331725; 18615103; 18767926; 18794057; 18976728; 19259613; 19275586; 19572148; 20147975; 20237496; 20379614; 21048031; 21081841; 21278227; 21329979; 21348573; 21460840; 21460841; 21906983; 21988832; 21993666; 22167654; 22382309; 23444229; 23623698; 23708142; 23946390
description: CD33 molecule
database cross reference: Ensembl:ENSG00000105383
database cross reference: HGNC:1659
database cross reference: HPRD:01165
database cross reference: MIM:159590
database cross reference: Vega:OTTHUMG00000182891

CD36
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BDPLT10
alternative term: CHDS7
alternative term: FAT
alternative term: GP3B
alternative term: GP4
alternative term: GPIV
alternative term: PASIV
alternative term: SCARB3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CD36
full name from nomenclature authority: CD36 molecule (thrombospondin receptor)
NCBI GeneID: 948
gene map location: 7q11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IEA); GO_0001954 (EC: IDA, PMID: 17416590); GO_0002224 (EC: TAS); GO_0002474 (EC: TAS); GO_0002479 (EC: TAS); GO_0002576 (EC: TAS); GO_0002755 (EC: TAS); GO_0005041 (EC: IMP, PMID: 10772654); GO_0005041 (EC: TAS, PMID: 9568716); GO_0005794 (EC: IEA); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 9568716); GO_0006629 (EC: NAS, PMID: 7518447); GO_0006898 (EC: IMP, PMID: 10772654); GO_0006898 (EC: TAS, PMID: 9568716); GO_0006910 (EC: IEA); GO_0007155 (EC: IEA); GO_0007166 (EC: IEA); GO_0007263 (EC: IDA, PMID: 17416590); GO_0007596 (EC: TAS); GO_0008035 (EC: IEA); GO_0008289 (EC: IDA, PMID: 10772654); GO_0009897 (EC: IEA); GO_0009986 (EC: IDA, PMID: 10772654); GO_0009986 (EC: ISS); GO_0010744 (EC: IMP, PMID: 10772654); GO_0010886 (EC: IEA); GO_0015911 (EC: IDA, PMID: 17416590); GO_0016020 (EC: TAS, PMID: 2468669); GO_0019915 (EC: IMP, PMID: 10772654); GO_0019934 (EC: IDA, PMID: 17416590); GO_0030168 (EC: TAS); GO_0030169 (EC: IDA, PMID: 10772654); GO_0030194 (EC: IEA); GO_0030301 (EC: ISS, PMID: 12376530); GO_0030666 (EC: TAS); GO_0031092 (EC: TAS); GO_0032735 (EC: IEA); GO_0032755 (EC: IEA); GO_0032760 (EC: IEA); GO_0034134 (EC: TAS); GO_0034142 (EC: TAS); GO_0034381 (EC: ISS, PMID: 12376530); GO_0034383 (EC: IMP, PMID: 10772654); GO_0035634 (EC: IEA); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042590 (EC: TAS); GO_0042953 (EC: IMP, PMID: 10772654); GO_0042953 (EC: TAS, PMID: 9568716); GO_0042992 (EC: IEA); GO_0043123 (EC: IEA); GO_0043277 (EC: IEA); GO_0043410 (EC: IEA); GO_0044130 (EC: IEA); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0044539 (EC: IDA); GO_0045087 (EC: TAS); GO_0045121 (EC: IEA); GO_0045335 (EC: TAS); GO_0050431 (EC: ISS); GO_0050731 (EC: IEA); GO_0050830 (EC: IEA); GO_0055096 (EC: IEA); GO_0060100 (EC: IEA); GO_0060907 (EC: IEA); GO_0070053 (EC: ISS); GO_0070892 (EC: IEA); GO_0071221 (EC: IEA); GO_0071222 (EC: IEA); GO_0071223 (EC: IEA); GO_0071447 (EC: IEA); GO_0071813 (EC: IDA, PMID: 9568716); GO_20…
has PubMed association: PMID: 1384492; 1715582; 2468669; 2468670; 2473841; 7503937; 7505064; 7518447; 7521304; 7533783; 7682812; 7686693; 7693034; 7693552; 8467233; 8561798; 8696942; 8798390; 9171348; 9334230; 9555943; 9568716; 10391209; 10487979; 10772654; 10772928; 10772961; 10890433; 11238109; 11377606; 11433350; 11602321; 11668637; 11686358; 11714819; 11718687; 11834946; 11867619; 11872368; 11950861; 12023894; 12031598; 12105195; 12164325; 12169456; 12224819; 12376530; 12477932; 12479587; 12496189; 12506336; 12516552; 12576469; 12598312; 12606036; 12618277; 12664607; 12679131; 12690205; 12716760; 12716848; 12732844; 12801610; 12947091; 12968020; 12971464; 14684613; 14699114; 14702039; 14719070; 14729862; 15048167; 15050739; 15059642; 15064117; 15132977; 15167446; 15221799; 15242332; 15282206; 15339698; 15342556; 15478802; 15489334; 15671915; 15677505; 15735450; 15780035; 15860439; 15897321; 15915335; 15933580; 15978955; 15979077; 16002039; 16037098; 16099393; 16219805; 16263699; 16276419; 16299313; 16344560; 16453284; 16515687; 16556603; 16622019; 16645727; 16670153; 16670819; 16838191; 16870193; 16880211; 16887969; 16908526; 16911630; 16952981; 17067553; 17071479; 17084382; 17311893; 17346709; 17380316; 17412877; 17416590; 17440173; 17496152; 17572512; 17573918; 17581812; 17619827; 17673938; 17710630; 17716309; 17854769; 17888147; 17900273; 17905828; 17924847; 18000176; 18029348; 18035074; 18053692; 18067591; 18263877; 18285332; 18288886; 18299339; 18305138; 18353783; 18441389; 18458151; 18462250; 18497330; 18514070; 18550349; 18558917; 18582374; 18660489; 18671254; 18827892; 18844973; 18981136; 19016618; 19055786; 19065049; 19088437; 19116451; 19136129; 19144874; 19156623; 19175917; 19185504; 19190027; 19203752; 19350111; 19369259; 19403559; 19413744; 19454037; 19489681; 19578796; 19640849; 19667111; 19718657; 19740737; 19864601; 19865095; 19876004; 19893500; 19913121; 19948975; 19996318; 20015873; 20023206; 20037584; 20075072; 20113368; 20139232; 20157514; 20223461; 20333725; 204087…
description: CD36 molecule (thrombospondin receptor)
database cross reference: Ensembl:ENSG00000135218
database cross reference: HGNC:1663
database cross reference: HPRD:01430
database cross reference: MIM:173510
database cross reference: Vega:OTTHUMG00000155383

CDK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CDC2
alternative term: CDC28A
alternative term: P34CDC2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CDK1
full name from nomenclature authority: cyclin-dependent kinase 1
NCBI GeneID: 983
gene map location: 10q21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000082 (EC: TAS); GO_0000083 (EC: TAS); GO_0000086 (EC: TAS); GO_0000165 (EC: TAS); GO_0000186 (EC: TAS); GO_0000187 (EC: TAS); GO_0000226 (EC: TAS); GO_0000278 (EC: TAS); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004672 (EC: NAS, PMID: 9001210); GO_0004674 (EC: IDA, PMID: 19879842); GO_0004693 (EC: IDA, PMID: 11069302); GO_0004693 (EC: TAS); GO_0005515 (EC: IPI, PMID: 10373560); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA); GO_0005739 (EC: TAS, PMID: 19917720); GO_0005815 (EC: IEA); GO_0005829 (EC: TAS); GO_0005876 (EC: IDA, PMID: 11069302); GO_0006260 (EC: TAS); GO_0006281 (EC: TAS); GO_0006461 (EC: IEA); GO_0006915 (EC: IEA); GO_0007067 (EC: IEA); GO_0007077 (EC: TAS); GO_0007095 (EC: IEA); GO_0007098 (EC: TAS, PMID: 19364923); GO_0007173 (EC: TAS); GO_0007264 (EC: TAS); GO_0007265 (EC: TAS); GO_0007344 (EC: TAS); GO_0007411 (EC: TAS); GO_0007569 (EC: IEA); GO_0008286 (EC: TAS); GO_0008353 (EC: IDA, PMID: 12721286); GO_0008543 (EC: TAS); GO_0009636 (EC: IEA); GO_0010628 (EC: IEA); GO_0014038 (EC: TAS, PMID: 17200138); GO_0014070 (EC: IEA); GO_0014075 (EC: IEA); GO_0014823 (EC: IEA); GO_0016477 (EC: TAS, PMID: 17200138); GO_0018105 (EC: IDA, PMID: 19879842); GO_0030261 (EC: IEA); GO_0030332 (EC: IEA); GO_0030496 (EC: IDA, PMID: 11069302); GO_0030544 (EC: IEA); GO_0030855 (EC: IEP); GO_0031100 (EC: IEA); GO_0031145 (EC: TAS); GO_0033160 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0034501 (EC: IDA, PMID: 18195732); GO_0035173 (EC: IEA); GO_0035666 (EC: TAS); GO_0038095 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042493 (EC: IEA); GO_0043066 (EC: IDA, PMID: 11069302); GO_0045087 (EC: TAS); GO_0045471 (EC: IEA); GO_0045740 (EC: IEA); GO_0045931 (EC: IEA); GO_0045995 (EC: TAS); GO_0046686 (EC: IEA); GO_0046688 (EC: IEA); GO_0048011 (EC: TAS); GO_0048678 (EC: IEA); GO_0051403 (EC: T…
has PubMed association: PMID: 914146; 1310466; 1318195; 1384126; 1388288; 1400350; 1406653; 1425574; 1628647; 1717476; 1748630; 1756735; 1828290; 1916766; 1939057; 2013279; 2183353; 2227411; 2344612; 2473839; 2538242; 2541912; 2570636; 2686978; 3289755; 3553962; 7474080; 7474100; 7494303; 7499230; 7578274; 7590285; 7592773; 7635160; 7666531; 7673335; 7716549; 7724583; 7737117; 7769006; 7790358; 7799941; 7822264; 7876309; 7902715; 7903056; 7925482; 7944411; 7949095; 7969176; 7983050; 8034666; 8051108; 8051175; 8070405; 8084605; 8087847; 8119945; 8125092; 8127873; 8242750; 8325880; 8376365; 8397206; 8397207; 8404858; 8423786; 8428596; 8440392; 8463339; 8475101; 8491187; 8524869; 8548803; 8565853; 8626512; 8626527; 8631817; 8652557; 8662825; 8663071; 8672508; 8806671; 8910336; 9001210; 9053846; 9069267; 9094673; 9109675; 9126608; 9130708; 9141461; 9188632; 9199321; 9235942; 9242535; 9244350; 9247342; 9258347; 9268380; 9271440; 9295339; 9315091; 9315635; 9398320; 9467962; 9515786; 9520381; 9524113; 9525956; 9560267; 9575153; 9585407; 9600099; 9614189; 9668078; 9725910; 9733650; 9753325; 9774639; 9885575; 9891079; 9926943; 9988268; 9990288; 10077596; 10339564; 10359664; 10362260; 10373560; 10383391; 10395539; 10403367; 10497277; 10502411; 10504341; 10524633; 10564259; 10602502; 10636877; 10656688; 10712923; 10716937; 10747892; 10764745; 10766737; 10767298; 10769027; 10793135; 10825186; 10864927; 10884347; 10924145; 10938080; 10958988; 10973963; 11034995; 11069302; 11076863; 11076968; 11113134; 11113184; 11135364; 11136719; 11259605; 11278541; 11278991; 11285280; 11310559; 11326318; 11327730; 11331587; 11395479; 11444800; 11470801; 11504921; 11516829; 11520933; 11531413; 11549262; 11559705; 11574543; 11584018; 11598127; 11683421; 11687586; 11774038; 11779217; 11782384; 11836499; 11861764; 11878934; 11895447; 11901153; 11953320; 11980914; 11986303; 12058066; 12077309; 12107172; 12124778; 12145207; 12151413; 12177195; 12186947; 12190313; 12200623; 12221128; 12361598; 12372621; 12397081; 12407107; …
description: cyclin-dependent kinase 1
database cross reference: Ensembl:ENSG00000170312
database cross reference: HGNC:1722
database cross reference: HPRD:00302
database cross reference: MIM:116940
database cross reference: Vega:OTTHUMG00000018290

CDC42
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CDC42Hs
alternative term: G25K
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CDC42
full name from nomenclature authority: cell division cycle 42
NCBI GeneID: 998
NCBI LocusTag: RP1-224A6.5
gene map location: 1p36.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: ISS); GO_0002040 (EC: IEA); GO_0003161 (EC: IEA); GO_0003334 (EC: IEA); GO_0003924 (EC: TAS, PMID: 11035016); GO_0005515 (EC: IPI, PMID: 10051605); GO_0005525 (EC: IEA); GO_0005737 (EC: IDA, PMID: 11260256); GO_0005815 (EC: IEA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 11260256); GO_0005886 (EC: TAS); GO_0006184 (EC: TAS, PMID: 11035016); GO_0007030 (EC: ISS); GO_0007088 (EC: IEA); GO_0007097 (EC: IEA); GO_0007163 (EC: TAS, PMID: 11260256); GO_0007173 (EC: TAS); GO_0007264 (EC: TAS); GO_0007411 (EC: TAS); GO_0007596 (EC: TAS); GO_0010628 (EC: IEA); GO_0010629 (EC: IEA); GO_0016020 (EC: IDA, PMID: 11807099); GO_0019901 (EC: IDA, PMID: 19039103); GO_0019901 (EC: IPI); GO_0021762 (EC: IEP); GO_0030036 (EC: IDA, PMID: 11035016); GO_0030141 (EC: IEA); GO_0030175 (EC: IDA, PMID: 11035016); GO_0030225 (EC: TAS, PMID: 11260256); GO_0030496 (EC: IDA, PMID: 15642749); GO_0030742 (EC: IEA); GO_0031069 (EC: IEA); GO_0031274 (EC: IDA, PMID: 11035016); GO_0031295 (EC: TAS); GO_0031333 (EC: IPI, PMID: 11584266); GO_0031424 (EC: IEA); GO_0031435 (EC: IEA); GO_0031647 (EC: IEA); GO_0031996 (EC: IPI, PMID: 12612085); GO_0032467 (EC: IMP, PMID: 15642749); GO_0033138 (EC: IEA); GO_0034191 (EC: IPI, PMID: 16443932); GO_0034332 (EC: IEA); GO_0034613 (EC: IEA); GO_0035088 (EC: IEA); GO_0035264 (EC: IEA); GO_0038096 (EC: TAS); GO_0042059 (EC: TAS); GO_0042176 (EC: IEA); GO_0042692 (EC: TAS); GO_0042802 (EC: IPI, PMID: 9748241); GO_0043005 (EC: IDA); GO_0043025 (EC: IDA); GO_0043497 (EC: IEA); GO_0043525 (EC: IEA); GO_0043552 (EC: IEA); GO_0045087 (EC: TAS); GO_0045177 (EC: IEA); GO_0045740 (EC: IEA); GO_0045859 (EC: IEA); GO_0046330 (EC: IEA); GO_0046847 (EC: IEA); GO_0048554 (EC: IEA); GO_0048664 (EC: IEA); GO_0051017 (EC: IEA); GO_0051056 (EC: TAS); GO_0051149 (EC: TAS); GO_0051233 (EC: IDA, PMID: 15642749); GO_0051489 (EC: IDA, PMID: 14978216); GO_0051683 (EC: ISS); GO_0051835 (EC: IEA); GO_0051988 (EC: IMP, PMID: 15642749); GO_0060047 (EC: IEA); GO_0060070 (EC:…
has PubMed association: PMID: 1898776; 1956381; 2122236; 2124704; 2496687; 7493928; 7513047; 7547927; 7629060; 7665558; 7738010; 7744004; 8034624; 8107774; 8625410; 8643625; 8670801; 8702968; 8755667; 8756646; 8798539; 8889548; 8943016; 8969170; 8994833; 9032261; 9079650; 9082982; 9113980; 9182573; 9210375; 9220962; 9262406; 9268338; 9338791; 9381982; 9407060; 9418861; 9422512; 9427749; 9490022; 9535835; 9535855; 9582072; 9642115; 9660763; 9705280; 9742969; 9748241; 9760238; 9786927; 9799233; 9822598; 9846874; 9860974; 10051605; 10068673; 10211824; 10320322; 10360578; 10360579; 10366564; 10480361; 10490598; 10551883; 10587647; 10676816; 10684602; 10713100; 10713183; 10724160; 10733591; 10747870; 10749885; 10781580; 10799501; 10799524; 10802735; 10816584; 10818149; 10854437; 10873802; 10934474; 10954424; 10954711; 10967094; 10975523; 11035016; 11090627; 11130076; 11157984; 11162552; 11257000; 11260256; 11278572; 11284700; 11287617; 11331876; 11394904; 11431473; 11432776; 11438723; 11583574; 11584266; 11584276; 11672528; 11696321; 11756552; 11773441; 11807099; 11822867; 11839748; 11884513; 11889037; 11907271; 11943145; 11948177; 11973651; 11998687; 12006984; 12032833; 12093730; 12110184; 12115629; 12172552; 12181570; 12235133; 12270144; 12369824; 12376551; 12421766; 12426222; 12432077; 12446789; 12453877; 12456510; 12477932; 12504591; 12511425; 12538863; 12547822; 12584113; 12595527; 12606577; 12612085; 12650940; 12745076; 12767056; 12769846; 12819203; 12824775; 12857875; 12860998; 12879077; 12887916; 12887922; 12887923; 12900413; 12901880; 12915445; 12928366; 12944407; 12960245; 12960248; 12972601; 14505571; 14530271; 14563854; 14597672; 14656933; 14676191; 14699061; 14701795; 14733946; 14749388; 14970210; 14978216; 15023524; 15075243; 15085137; 15102814; 15121898; 15123659; 15123662; 15133042; 15147912; 15187089; 15194684; 15260990; 15265891; 15287724; 15304341; 15306850; 15355962; 15361624; 15451670; 15472119; 15485837; 15489334; 15616194; 15642749; 15649357; 15652341; 15652748; 15655247;…
description: cell division cycle 42
database cross reference: Ensembl:ENSG00000070831
database cross reference: HGNC:1736
database cross reference: HPRD:00309
database cross reference: MIM:116952
database cross reference: Vega:OTTHUMG00000002753

CDH2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD325
alternative term: CDHN
alternative term: CDw325
alternative term: NCAD
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CDH2
full name from nomenclature authority: cadherin 2, type 1, N-cadherin (neuronal)
NCBI GeneID: 1000
gene map location: 18q11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 18
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005509 (EC: IEA); GO_0005515 (EC: IPI, PMID: 17057644); GO_0005886 (EC: TAS); GO_0005911 (EC: IDA, PMID: 7650039); GO_0005913 (EC: IDA, PMID: 19101069); GO_0005916 (EC: IEA); GO_0007155 (EC: TAS, PMID: 2384753); GO_0007156 (EC: IEA); GO_0007157 (EC: IEA); GO_0008013 (EC: TAS, PMID: 16344550); GO_0014704 (EC: ISS); GO_0016021 (EC: IEA); GO_0016324 (EC: IEA); GO_0016339 (EC: IEA); GO_0016342 (EC: IDA, PMID: 7650039); GO_0016477 (EC: IEA); GO_0019903 (EC: IEA); GO_0030027 (EC: IEA); GO_0034329 (EC: TAS); GO_0034332 (EC: TAS); GO_0042692 (EC: TAS); GO_0043410 (EC: IEA); GO_0045202 (EC: IEA); GO_0045216 (EC: TAS); GO_0045294 (EC: IPI, PMID: 7650039); GO_0045295 (EC: IPI, PMID: 7650039); GO_0048514 (EC: IEA); GO_0051146 (EC: IEA); GO_0051149 (EC: TAS); GO_0090090 (EC: IEA)
has PubMed association: PMID: 1500442; 1639850; 2216790; 2384753; 7650039; 7731968; 7806582; 7959764; 7995652; 8074697; 9168198; 9199196; 9219219; 9508779; 9542583; 9615235; 9971746; 10662782; 10818391; 10862698; 11058098; 11106648; 11136230; 11329013; 11729199; 11790800; 11821434; 11835406; 11996105; 12057916; 12077367; 12095980; 12151522; 12377785; 12398894; 12438242; 12477932; 12503652; 12531901; 12545205; 12604612; 12615965; 12634428; 12639940; 13678586; 14515347; 14559901; 14625392; 14675278; 15146197; 15153430; 15192701; 15217949; 15252840; 15263022; 15331629; 15355896; 15527101; 15541732; 15648948; 15701645; 15713751; 15731052; 15774907; 15855653; 15923648; 15987741; 16007225; 16091424; 16149052; 16173043; 16212419; 16258702; 16344550; 16344560; 16371504; 16596172; 16675571; 16707106; 16819153; 16969099; 17008425; 17031402; 17057644; 17060906; 17171299; 17178870; 17229887; 17255093; 17348027; 17389597; 17512904; 17646933; 17668445; 17868645; 17944884; 18269586; 18362184; 18414176; 18495274; 18622386; 18801083; 18978678; 18979298; 19033391; 19043453; 19070520; 19101069; 19124205; 19167335; 19190132; 19222093; 19324354; 19339270; 19448425; 19501458; 19530221; 19580633; 19584275; 19898423; 19919954; 20082286; 20116358; 20117462; 20137108; 20139113; 20204300; 20233707; 20308060; 20371349; 20379614; 20388391; 20451421; 20605145; 20630685; 20634891; 20664068; 20735983; 20738806; 20811707; 21042713; 21057494; 21070371; 21080917; 21084302; 21122409; 21123580; 21139048; 21156175; 21176502; 21177868; 21315068; 21315259; 21423153; 21596022; 21777276; 21785870; 21810271; 21828122; 21845495; 21852538; 21855541; 21858092; 21875946; 21890473; 21988832; 21990317; 22040951; 22072429; 22166980; 22275437; 22344255; 22360503; 22365631; 22385354; 22405962; 22490800; 22490896; 22576709; 22615994; 22632162; 22637581; 22767590; 22810307; 22846995; 22888908; 22912891; 22939629; 22976797; 23000965; 23086683; 23240619; 23251661; 23276695; 23290789; 23314748; 23314859; 23321619; 23398382; 23420609; 23438504; 2…
description: cadherin 2, type 1, N-cadherin (neuronal)
database cross reference: Ensembl:ENSG00000170558
database cross reference: HGNC:1759
database cross reference: HPRD:00226
database cross reference: MIM:114020
database cross reference: Vega:OTTHUMG00000059940

CDK4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CMM3
alternative term: PSK-J3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CDK4
full name from nomenclature authority: cyclin-dependent kinase 4
NCBI GeneID: 1019
gene map location: 12q14
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000082 (EC: IMP, PMID: 7603984); GO_0000278 (EC: TAS); GO_0000307 (EC: IDA, PMID: 17420273); GO_0000785 (EC: IDA, PMID: 18827403); GO_0004693 (EC: IDA, PMID: 8114739); GO_0005515 (EC: IPI, PMID: 11896535); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA, PMID: 16109376); GO_0005654 (EC: TAS); GO_0005667 (EC: IEA); GO_0005730 (EC: IDA, PMID: 18827403); GO_0005829 (EC: IDA, PMID: 18827403); GO_0005829 (EC: TAS); GO_0005923 (EC: IEA); GO_0006468 (EC: IDA, PMID: 8114739); GO_0007165 (EC: IEA); GO_0007623 (EC: IEA); GO_0008284 (EC: IMP, PMID: 7603984); GO_0009636 (EC: IEA); GO_0010288 (EC: IEA); GO_0010468 (EC: IMP, PMID: 17420273); GO_0010971 (EC: IDA, PMID: 19124461); GO_0030332 (EC: IPI, PMID: 19124461); GO_0031100 (EC: IEA); GO_0031965 (EC: IDA, PMID: 18827403); GO_0032403 (EC: IEA); GO_0033574 (EC: IEA); GO_0042493 (EC: IGI, PMID: 18291362); GO_0043065 (EC: IEA); GO_0045727 (EC: IEA); GO_0045793 (EC: IEA); GO_0048146 (EC: IMP, PMID: 17420273); GO_0048471 (EC: IEA); GO_0051301 (EC: IEA); GO_0055093 (EC: IEA); GO_0071157 (EC: IDA, PMID: 19124461)
has PubMed association: PMID: 2948189; 7478582; 7568034; 7603984; 7606365; 7652577; 7739547; 7739548; 8001816; 8078588; 8101826; 8114739; 8139570; 8221695; 8259215; 8275715; 8449399; 8528263; 8619474; 8622677; 8626527; 8647086; 8662825; 8666233; 8703009; 8741839; 8756624; 8805225; 8867812; 8978686; 8999999; 9003781; 9106657; 9110174; 9111314; 9139732; 9150368; 9163429; 9178893; 9190208; 9192850; 9199321; 9228064; 9244350; 9311594; 9311993; 9315635; 9372967; 9380698; 9396813; 9425228; 9464540; 9482104; 9529249; 9545286; 9632134; 9658399; 9716181; 9837900; 9840932; 10022835; 10049762; 10198259; 10202152; 10342870; 10353443; 10359664; 10447003; 10486249; 10491434; 10499802; 10580009; 10585280; 10601020; 10602502; 10639311; 10713676; 10719365; 10748174; 10788489; 10908655; 11120786; 11132966; 11157749; 11254678; 11254741; 11291051; 11310559; 11358847; 11360184; 11395479; 11426564; 11556834; 11668523; 11684017; 11779854; 11828258; 11867521; 11884610; 11896535; 11900540; 11940657; 11971966; 11982759; 12006580; 12036888; 12036906; 12077343; 12082615; 12130539; 12190313; 12357246; 12383116; 12477932; 12509456; 12519773; 12529334; 12531694; 12545164; 12565795; 12601350; 12676926; 12680219; 12684681; 12731669; 12857727; 12949733; 14641107; 14646596; 14647432; 14672406; 14694185; 14701845; 14754892; 15003538; 15004027; 15024701; 15050687; 15065884; 15147269; 15169570; 15169919; 15208653; 15232106; 15241418; 15480536; 15489334; 15505422; 15558030; 15695403; 15761153; 15797629; 15821902; 15860862; 15880589; 15922743; 15998794; 16109376; 16169070; 16189514; 16205633; 16326706; 16413469; 16449650; 16476733; 16582606; 16601140; 16690963; 16758952; 16782892; 16913845; 16949366; 16962592; 16985050; 17015477; 17043357; 17047042; 17053782; 17072968; 17139501; 17205132; 17274640; 17304504; 17334399; 17353931; 17374178; 17409409; 17420273; 17505264; 17517622; 17530187; 17540176; 17556661; 17620599; 17664862; 17881001; 17892862; 17895748; 17909018; 17955473; 18006822; 18023021; 18174243; 18202766; 18281541; 1828…
description: cyclin-dependent kinase 4
database cross reference: Ensembl:ENSG00000135446
database cross reference: HGNC:1773
database cross reference: HPRD:00447
database cross reference: MIM:123829
database cross reference: Vega:OTTHUMG00000170382

CDK5
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PSSALRE
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CDK5
full name from nomenclature authority: cyclin-dependent kinase 5
NCBI GeneID: 1020
gene map location: 7q36
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001764 (EC: TAS); GO_0001963 (EC: IEA); GO_0002039 (EC: IEA); GO_0004672 (EC: TAS, PMID: 1639063); GO_0004674 (EC: IDA); GO_0004674 (EC: ISS); GO_0004674 (EC: TAS); GO_0004693 (EC: ISS); GO_0005176 (EC: ISS); GO_0005515 (EC: IPI, PMID: 12223541); GO_0005524 (EC: IEA); GO_0005634 (EC: ISS); GO_0005737 (EC: ISS); GO_0005829 (EC: TAS); GO_0006886 (EC: IEA); GO_0006913 (EC: IEA); GO_0007160 (EC: IEA); GO_0007268 (EC: TAS); GO_0007411 (EC: TAS); GO_0007416 (EC: TAS); GO_0007519 (EC: IEA); GO_0007596 (EC: TAS); GO_0008045 (EC: IEA); GO_0008283 (EC: TAS, PMID: 8090221); GO_0008542 (EC: IEA); GO_0009790 (EC: ISS); GO_0014044 (EC: IEA); GO_0014069 (EC: ISS); GO_0016020 (EC: ISS); GO_0016079 (EC: TAS); GO_0016301 (EC: ISS); GO_0016310 (EC: IDA); GO_0016533 (EC: IEA); GO_0018105 (EC: IDA); GO_0018107 (EC: IEA); GO_0019233 (EC: IEA); GO_0021697 (EC: IEA); GO_0021766 (EC: IEA); GO_0021819 (EC: IEA); GO_0021954 (EC: IEA); GO_0022038 (EC: IEA); GO_0030027 (EC: IEA); GO_0030054 (EC: IEA); GO_0030175 (EC: IEA); GO_0030182 (EC: ISS); GO_0030182 (EC: TAS); GO_0030334 (EC: IEA); GO_0030424 (EC: ISS); GO_0030425 (EC: ISS); GO_0030426 (EC: ISS); GO_0030517 (EC: IEA); GO_0030549 (EC: ISS); GO_0030866 (EC: IEA); GO_0031175 (EC: ISS); GO_0031397 (EC: IEA); GO_0031594 (EC: ISS); GO_0031914 (EC: IEA); GO_0032092 (EC: IEA); GO_0032801 (EC: IEA); GO_0033136 (EC: IEA); GO_0035249 (EC: IEA); GO_0035418 (EC: IEA); GO_0042981 (EC: TAS); GO_0043025 (EC: ISS); GO_0043113 (EC: IEA); GO_0043125 (EC: ISS); GO_0043204 (EC: IEA); GO_0043525 (EC: ISS); GO_0045055 (EC: IEA); GO_0045211 (EC: IEA); GO_0045786 (EC: IEA); GO_0045860 (EC: IEA); GO_0045892 (EC: IMP); GO_0045956 (EC: IEA); GO_0046777 (EC: IEA); GO_0046826 (EC: IEA); GO_0046875 (EC: IEA); GO_0048148 (EC: IEA); GO_0048167 (EC: ISS); GO_0048167 (EC: TAS); GO_0048488 (EC: TAS); GO_0048675 (EC: TAS); GO_0048709 (EC: IDA, PMID: 18042622); GO_0048813 (EC: IEA); GO_0050321 (EC: ISS); GO_0051301 (EC: IEA); GO_0051402 (EC: TAS); GO_0060079 (EC: IEA); GO…
has PubMed association: PMID: 1181841; 1330687; 1639063; 7566346; 7834371; 7949095; 8090221; 8090222; 8275715; 8702879; 8764598; 8891282; 9013862; 9038181; 9150368; 9199504; 9244350; 9353289; 9396813; 9422379; 9478941; 9545286; 9546672; 9565682; 9596352; 9614189; 9735171; 9771888; 9832145; 10049762; 10500146; 10544291; 10604473; 10683146; 10721722; 10762698; 10884347; 10896159; 10915792; 10936190; 10995546; 11104762; 11113134; 11163260; 11168528; 11181841; 11254741; 11278541; 11311121; 11320080; 11389014; 11483158; 11516829; 11583627; 11604394; 11675505; 11684694; 11733001; 11741927; 11743029; 11784720; 11823425; 11865137; 11882646; 11955625; 12056836; 12064478; 12071639; 12077184; 12084709; 12154070; 12223541; 12226093; 12372285; 12372407; 12387894; 12435421; 12477932; 12491158; 12690205; 12691662; 12765608; 12769842; 12796778; 12824184; 12826674; 12832492; 12832520; 12855954; 12963086; 12970441; 12972605; 14521924; 14704270; 14741103; 15013773; 15030318; 15123618; 15178331; 15342556; 15345747; 15489224; 15489334; 15492003; 15652488; 15741232; 15790807; 15834155; 15890360; 15911879; 15917097; 16327995; 16356933; 16407256; 16413130; 16519508; 16712791; 16862120; 17036052; 17045592; 17060323; 17078951; 17121855; 17145757; 17290217; 17327227; 17419807; 17491008; 17493033; 17581253; 17591690; 17611284; 17713927; 17762160; 17906618; 18042622; 18076569; 18247371; 18326489; 18350355; 18408012; 18460467; 18480410; 18487454; 18490454; 18598350; 18676680; 19001851; 19050041; 19170196; 19343042; 19363486; 19514266; 19514267; 19514268; 19615060; 19625176; 19692168; 19693690; 19700222; 19718565; 19764350; 19822667; 19913121; 19953087; 19960242; 20013135; 20133653; 20213743; 20234188; 20345761; 20354813; 20357208; 20360068; 20379614; 20453000; 20491486; 20516069; 20628086; 20651683; 20673369; 20720012; 20826806; 21044075; 21139048; 21145489; 21163940; 21209322; 21220307; 21289309; 21335063; 21415596; 21435449; 21465480; 21482751; 21600237; 21671254; 21701498; 21712386; 21741478; 21799006; 21825040; 218…
description: cyclin-dependent kinase 5
database cross reference: HGNC:1774
database cross reference: HPRD:00449
database cross reference: MIM:123831

CDKN1A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CAP20
alternative term: CDKN1
alternative term: CIP1
alternative term: MDA-6
alternative term: P21
alternative term: SDI1
alternative term: WAF1
alternative term: p21CIP1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CDKN1A
full name from nomenclature authority: cyclin-dependent kinase inhibitor 1A (p21, Cip1)
NCBI GeneID: 1026
gene map location: 6p21.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000079 (EC: TAS, PMID: 8242751); GO_0000082 (EC: IDA, PMID: 10208428); GO_0000082 (EC: TAS); GO_0000086 (EC: IMP, PMID: 17553787); GO_0000278 (EC: TAS); GO_0000307 (EC: IDA, PMID: 17420273); GO_0004861 (EC: TAS, PMID: 7958916); GO_0005515 (EC: IPI, PMID: 15232106); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005829 (EC: TAS); GO_0006468 (EC: IDA, PMID: 9106657); GO_0006974 (EC: IMP); GO_0006977 (EC: IDA, PMID: 15149599); GO_0006977 (EC: TAS); GO_0007050 (EC: IDA, PMID: 15149599); GO_0007050 (EC: IMP, PMID: 17553787); GO_0007173 (EC: TAS); GO_0007265 (EC: IEP, PMID: 9054499); GO_0008285 (EC: IDA, PMID: 10208428); GO_0008285 (EC: IMP, PMID: 17553787); GO_0008543 (EC: TAS); GO_0009411 (EC: IEA); GO_0009636 (EC: IEA); GO_0010243 (EC: IEA); GO_0010629 (EC: IEA); GO_0019912 (EC: IDA, PMID: 9106657); GO_0030308 (EC: IDA, PMID: 10208428); GO_0030332 (EC: IEA); GO_0030890 (EC: IEA); GO_0031100 (EC: IEA); GO_0031668 (EC: IMP, PMID: 17553787); GO_0032403 (EC: IEA); GO_0033158 (EC: IEA); GO_0038095 (EC: TAS); GO_0042326 (EC: IDA, PMID: 10208428); GO_0042493 (EC: IEA); GO_0042771 (EC: IEA); GO_0043066 (EC: IEA); GO_0043068 (EC: IEA); GO_0043231 (EC: IDA); GO_0045087 (EC: TAS); GO_0045736 (EC: IEA); GO_0045860 (EC: IDA, PMID: 9106657); GO_0046685 (EC: IEA); GO_0046872 (EC: IEA); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0048146 (EC: IMP, PMID: 17420273); GO_0051412 (EC: IEA); GO_0055093 (EC: IEA); GO_0070557 (EC: IDA, PMID: 18794347); GO_0071479 (EC: IMP); GO_0071850 (EC: IEA); GO_0090398 (EC: IMP, PMID: 15149599); GO_0090400 (EC: TAS); GO_0097193 (EC: TAS, PMID: 9660939); GO_2000278 (EC: IEA); GO_2000379 (EC: IMP)
has PubMed association: PMID: 7478582; 7478594; 7655464; 7698009; 7753561; 7780738; 7911228; 7958916; 8084608; 8101826; 8125163; 8242751; 8242752; 8259214; 8560263; 8622677; 8641969; 8647134; 8657154; 8662825; 8700517; 8756624; 8807325; 8861913; 8861969; 8891332; 8999999; 9054499; 9106657; 9178907; 9190208; 9218599; 9372966; 9380407; 9396813; 9464540; 9465025; 9467962; 9472014; 9515786; 9545252; 9546435; 9632134; 9658399; 9660939; 9705499; 9716181; 9716736; 9736735; 9798959; 9799125; 9811456; 9822382; 9837900; 9840927; 9840943; 9858585; 9858587; 10022118; 10022926; 10208428; 10323868; 10337545; 10455148; 10486249; 10529385; 10581175; 10679299; 10692450; 10698951; 10710306; 10753973; 10764767; 10828884; 10837373; 10848585; 10858286; 10873631; 10874474; 10878006; 10891505; 10912791; 10918595; 10973963; 11022036; 11076863; 11084299; 11132966; 11175348; 11179504; 11231585; 11254741; 11255227; 11302688; 11313979; 11343236; 11350925; 11389691; 11463845; 11477082; 11498536; 11559705; 11642719; 11684722; 11695244; 11700040; 11733969; 11741909; 11748297; 11751405; 11751903; 11756412; 11762751; 11781193; 11809712; 11815410; 11842244; 11860939; 11872638; 11877274; 11877298; 11877436; 11882322; 11893252; 11896572; 11908736; 11911463; 11931757; 11943869; 11953864; 11956602; 11968052; 11989975; 12015083; 12025230; 12036888; 12046058; 12052868; 12054510; 12054572; 12054658; 12055678; 12058028; 12111504; 12123335; 12138103; 12145325; 12151346; 12151347; 12151395; 12168821; 12204872; 12205674; 12354776; 12359245; 12361598; 12370305; 12379120; 12383116; 12384701; 12388558; 12392301; 12393707; 12396717; 12400017; 12407107; 12412576; 12417334; 12417722; 12429910; 12431783; 12431987; 12434183; 12441075; 12457968; 12459877; 12474524; 12477932; 12485998; 12513833; 12517948; 12519780; 12522211; 12527941; 12531694; 12545156; 12573582; 12599217; 12612054; 12642873; 12644083; 12651158; 12665570; 12665584; 12680256; 12681289; 12690110; 12698196; 12699883; 12705898; 12706118; 12716906; 12727210; 12727815; 12748190; 12…
description: cyclin-dependent kinase inhibitor 1A (p21, Cip1)
database cross reference: Ensembl:ENSG00000124762
database cross reference: HGNC:1784
database cross reference: HPRD:00298
database cross reference: MIM:116899
database cross reference: Vega:OTTHUMG00000014603

CDKN2A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ARF
alternative term: CDK4I
alternative term: CDKN2
alternative term: CMM2
alternative term: INK4
alternative term: INK4A
alternative term: MLM
alternative term: MTS-1
alternative term: MTS1
alternative term: P14
alternative term: P14ARF
alternative term: P16
alternative term: P16-INK4A
alternative term: P16INK4
alternative term: P16INK4A
alternative term: P19
alternative term: P19ARF
alternative term: TP16
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CDKN2A
full name from nomenclature authority: cyclin-dependent kinase inhibitor 2A
NCBI GeneID: 1029
gene map location: 9p21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000075 (EC: IMP, PMID: 16243918); GO_0000082 (EC: IDA, PMID: 10208428); GO_0000209 (EC: IDA, PMID: 18305112); GO_0000278 (EC: TAS); GO_0001953 (EC: IMP, PMID: 10205165); GO_0002039 (EC: IPI, PMID: 9529249); GO_0003677 (EC: IEA); GO_0004861 (EC: IDA, PMID: 8259215); GO_0005515 (EC: IPI, PMID: 11278317); GO_0005634 (EC: IDA, PMID: 16243918); GO_0005654 (EC: IDA, PMID: 10360174); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA); GO_0005737 (EC: IDA, PMID: 16243918); GO_0005739 (EC: IEA); GO_0005829 (EC: TAS); GO_0006351 (EC: IEA); GO_0006364 (EC: IEA); GO_0006469 (EC: IMP, PMID: 15582998); GO_0006919 (EC: IMP, PMID: 12082630); GO_0007050 (EC: IDA, PMID: 15149599); GO_0007050 (EC: IMP, PMID: 16243918); GO_0007265 (EC: IEP, PMID: 9054499); GO_0008134 (EC: IPI, PMID: 19057511); GO_0008285 (EC: IDA, PMID: 15149599); GO_0008285 (EC: IMP, PMID: 16243918); GO_0008637 (EC: IMP, PMID: 12082630); GO_0010389 (EC: IMP, PMID: 15582998); GO_0016604 (EC: IDA, Qualifier: colocalizes_with, PMID: 10360174); GO_0019901 (EC: IPI, PMID: 8259215); GO_0030308 (EC: IDA, PMID: 10208428); GO_0030889 (EC: ISS); GO_0031647 (EC: ISS); GO_0031648 (EC: IDA, PMID: 9529249); GO_0032088 (EC: IDA, PMID: 10353611); GO_0033088 (EC: ISS); GO_0033235 (EC: IMP, PMID: 19057511); GO_0034393 (EC: ISS); GO_0035985 (EC: IDA, PMID: 16901784); GO_0035986 (EC: IMP, PMID: 16901784); GO_0042326 (EC: IDA, PMID: 10208428); GO_0043234 (EC: IDA, PMID: 9529249); GO_0043517 (EC: IDA, PMID: 9529249); GO_0044822 (EC: IDA); GO_0045736 (EC: IDA, PMID: 8259215); GO_0045892 (EC: IMP, PMID: 16901784); GO_0045893 (EC: IDA, PMID: 17569660); GO_0045944 (EC: IDA, PMID: 17569660); GO_0046825 (EC: IMP, PMID: 10360174); GO_0048103 (EC: ISS); GO_0050821 (EC: IDA, PMID: 10360174); GO_0051059 (EC: IDA, PMID: 10353611); GO_0051444 (EC: ISS); GO_0055105 (EC: ISS); GO_0070534 (EC: IDA, PMID: 18305112); GO_0071158 (EC: IDA, PMID: 9529249); GO_0090398 (EC: IMP, PMID: 14966292); GO_0090399 (EC: IMP, PMID: 14720514); GO_0097371 (EC: IPI, PMID: 95292…
has PubMed association: PMID: 7541708; 7603984; 7604013; 7624129; 7624155; 7647780; 7726912; 7882351; 7970734; 7972006; 7987387; 7987388; 8060323; 8152487; 8153634; 8259215; 8595405; 8622687; 8710906; 8723678; 8755727; 8783570; 8805225; 8910511; 9054499; 9228064; 9328469; 9380698; 9425228; 9482104; 9516223; 9529248; 9529249; 9653180; 9724636; 9751050; 10205165; 10208428; 10353611; 10360174; 10445844; 10484981; 10491434; 10556039; 10580009; 10585280; 10651484; 10719365; 10801444; 10822382; 10871849; 10874641; 10891505; 10892805; 10956390; 11008905; 11136714; 11156381; 11223036; 11278317; 11297540; 11314011; 11314038; 11382768; 11500805; 11556834; 11642719; 11668523; 11687599; 11692873; 11695244; 11700040; 11705866; 11718560; 11719461; 11720478; 11726555; 11733969; 11739795; 11740049; 11749694; 11758167; 11763427; 11775544; 11792819; 11800646; 11804283; 11807902; 11820732; 11830494; 11836163; 11836554; 11839577; 11839665; 11850526; 11859122; 11859969; 11860939; 11861400; 11869511; 11869517; 11874489; 11883935; 11889694; 11900540; 11908877; 11920239; 11920642; 11943335; 11948103; 11953887; 11956078; 11960384; 11960918; 11992549; 12000709; 12009890; 12016143; 12036898; 12046062; 12060387; 12065407; 12072536; 12072543; 12073046; 12077343; 12082609; 12082610; 12082630; 12082636; 12085228; 12091906; 12099684; 12101111; 12101670; 12107107; 12115568; 12124774; 12127556; 12149228; 12151395; 12152785; 12154087; 12168936; 12169206; 12199782; 12200117; 12203782; 12209876; 12228235; 12296515; 12297306; 12357355; 12359767; 12360404; 12360471; 12362978; 12362979; 12368906; 12370286; 12391839; 12406345; 12417717; 12419160; 12420227; 12429789; 12438273; 12446718; 12454511; 12459643; 12459644; 12459645; 12477932; 12482990; 12507899; 12507935; 12514789; 12529334; 12532425; 12549483; 12556369; 12556559; 12565176; 12581788; 12581892; 12582152; 12592382; 12606707; 12610506; 12624503; 12632489; 12632492; 12640129; 12660818; 12665584; 12670910; 12673200; 12684623; 12684640; 12698196; 12702553; 12717828; 12738733; …
description: cyclin-dependent kinase inhibitor 2A
database cross reference: Ensembl:ENSG00000147889
database cross reference: HGNC:1787
database cross reference: HPRD:02542
database cross reference: MIM:600160
database cross reference: Vega:OTTHUMG00000019686

CDO1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CDO1
full name from nomenclature authority: cysteine dioxygenase type 1
NCBI GeneID: 1036
gene map location: 5q23.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000096 (EC: TAS); GO_0000097 (EC: TAS, PMID: 12110289); GO_0000098 (EC: TAS); GO_0005829 (EC: TAS, PMID: 12110289); GO_0006534 (EC: TAS, PMID: 12110289); GO_0006954 (EC: TAS, PMID: 12110289); GO_0007595 (EC: IEA); GO_0008198 (EC: IEA); GO_0017172 (EC: ISS); GO_0017172 (EC: TAS); GO_0019448 (EC: IEA); GO_0033762 (EC: IEA); GO_0034641 (EC: TAS); GO_0042412 (EC: IEA); GO_0042412 (EC: TAS, PMID: 12871209); GO_0043200 (EC: IEA); GO_0044281 (EC: TAS); GO_0045471 (EC: IEA); GO_0051384 (EC: IEA); GO_0051591 (EC: IEA); GO_0055114 (EC: TAS, PMID: 12110289)
has PubMed association: PMID: 7524679; 8835096; 9497919; 11101006; 12110289; 12477932; 12871209; 15302935; 15489334; 17207965; 17327371; 17353931; 18033314; 18976975; 19199799; 20515469; 21139048; 21988832; 22011669; 23028699; 23630167
description: cysteine dioxygenase type 1

CETP
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BPIFF
alternative term: HDLCQ10
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CETP
full name from nomenclature authority: cholesteryl ester transfer protein, plasma
NCBI GeneID: 1071
gene map location: 16q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005319 (EC: IDA, PMID: 2833496); GO_0005548 (EC: IDA, PMID: 2833496); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 3104518); GO_0006641 (EC: IDA, PMID: 2833496); GO_0006869 (EC: IDA, PMID: 3818596); GO_0006898 (EC: TAS); GO_0008203 (EC: IDA, PMID: 2833496); GO_0008203 (EC: IMP, PMID: 2586614); GO_0008289 (EC: IDA, PMID: 3818596); GO_0010745 (EC: IC, PMID: 16670775); GO_0010874 (EC: IMP, PMID: 16670775); GO_0015485 (EC: IDA, PMID: 2833496); GO_0015914 (EC: IDA, PMID: 2833496); GO_0017127 (EC: IDA, PMID: 2833496); GO_0017129 (EC: IDA, PMID: 2833496); GO_0030301 (EC: IDA, PMID: 2833496); GO_0031210 (EC: IDA, PMID: 2833496); GO_0031982 (EC: IDA, PMID: 2833496); GO_0034364 (EC: IDA, PMID: 3104518); GO_0034372 (EC: IDA, PMID: 2833496); GO_0034374 (EC: IDA, PMID: 2833496); GO_0034375 (EC: IMP, PMID: 2586614); GO_0042157 (EC: TAS); GO_0042632 (EC: IMP, PMID: 2586614); GO_0043691 (EC: IC, PMID: 7583561); GO_0044281 (EC: TAS); GO_0046470 (EC: IDA, PMID: 2833496); GO_0055088 (EC: IDA, PMID: 3818596); GO_0055091 (EC: IDA, PMID: 2833496); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070328 (EC: IDA, PMID: 2833496)
has PubMed association: PMID: 1999438; 2215607; 2334701; 2390095; 2586614; 2833496; 3104518; 3446583; 3600759; 3818596; 7583561; 7989465; 8132678; 8408659; 8494888; 8943225; 9305883; 9332354; 9374130; 9712344; 10391209; 11056092; 11096142; 11284423; 11322655; 11341749; 11359462; 11369008; 11398140; 11454014; 11533368; 11575217; 11689220; 11714857; 11730826; 11804197; 11810297; 11872695; 11882335; 11887180; 11888509; 11888533; 11903340; 11915346; 11952809; 11956670; 11996962; 12019635; 12033532; 12037734; 12048136; 12055319; 12070157; 12082592; 12091484; 12104085; 12116231; 12117730; 12164095; 12174215; 12401886; 12409629; 12446192; 12477932; 12482565; 12499392; 12514935; 12518020; 12519368; 12519369; 12544508; 12579494; 12588754; 12601526; 12639975; 12663600; 12669678; 12700892; 12730302; 12771320; 12771549; 12773093; 12791674; 12798569; 12818401; 12818414; 12820950; 12840632; 12871320; 12907677; 12919138; 12951364; 12966036; 14531818; 14559957; 14563342; 14583798; 14660992; 14669156; 14679166; 14687732; 14732872; 14967821; 14998629; 15036597; 15039125; 15053158; 15076187; 15085362; 15098490; 15099350; 15102891; 15138631; 15228446; 15256516; 15339254; 15377415; 15382463; 15450208; 15489334; 15585206; 15589073; 15608561; 15655129; 15696473; 15766738; 15811250; 15840744; 15856070; 15859394; 15864114; 15882786; 15888337; 15896905; 15939053; 15952120; 15955471; 15979432; 15992403; 15996208; 16002074; 16005462; 16030523; 16038892; 16039291; 16049032; 16086925; 16096813; 16098387; 16123327; 16141008; 16159884; 16169070; 16189514; 16205020; 16248996; 16306202; 16306375; 16326978; 16332659; 16335952; 16343038; 16384616; 16420563; 16426594; 16430904; 16522905; 16542392; 16544732; 16553359; 16563399; 16623947; 16670775; 16674961; 16684835; 16763159; 16770077; 16797310; 16822236; 16829344; 16837242; 16855190; 16890925; 16946130; 16986521; 17053273; 17055779; 17097007; 17108362; 17157861; 17160943; 17190939; 17196207; 17237796; 17272756; 17275808; 17287950; 17293475; 17310124; 17311515; 17318300; 1733…
description: cholesteryl ester transfer protein, plasma
database cross reference: Ensembl:ENSG00000087237
database cross reference: HGNC:1869
database cross reference: HPRD:00325
database cross reference: MIM:118470
database cross reference: Vega:OTTHUMG00000133279

CHRM1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HM1
alternative term: M1
alternative term: M1R
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CHRM1
full name from nomenclature authority: cholinergic receptor, muscarinic 1
NCBI GeneID: 1128
gene map location: 11q13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004435 (EC: TAS, PMID: 9614217); GO_0005886 (EC: TAS); GO_0005887 (EC: IEA); GO_0006464 (EC: TAS, PMID: 1411529); GO_0007165 (EC: TAS, PMID: 3443095); GO_0007186 (EC: TAS, PMID: 7925360); GO_0007205 (EC: TAS, PMID: 9603968); GO_0007207 (EC: TAS, PMID: 8139539); GO_0007213 (EC: TAS, PMID: 8139539); GO_0007274 (EC: IEA); GO_0007399 (EC: TAS, PMID: 2739737); GO_0008144 (EC: IEA); GO_0008283 (EC: TAS, PMID: 1905013); GO_0008284 (EC: TAS, PMID: 2739737); GO_0014069 (EC: IEA); GO_0016020 (EC: TAS, PMID: 7925360); GO_0016907 (EC: IEA); GO_0030054 (EC: IEA); GO_0030425 (EC: IEA); GO_0032279 (EC: IEA); GO_0040012 (EC: IEA); GO_0043270 (EC: IGI, PMID: 14657398); GO_0043679 (EC: IEA); GO_0045211 (EC: IEA); GO_0046541 (EC: IEA); GO_0050890 (EC: IEA); GO_0090316 (EC: IEA)
has PubMed association: PMID: 1411529; 1445347; 1905013; 2336407; 2674717; 2739737; 3037705; 3443095; 3697105; 7925360; 8063729; 8139539; 8190105; 8248499; 8508928; 8938448; 9303164; 9518684; 9603968; 9614217; 10333492; 10336173; 11306684; 11855742; 12049494; 12476323; 12477932; 12694403; 12707929; 12810581; 12851722; 14504414; 14657398; 15086532; 15280370; 15383745; 15452121; 15489334; 16318751; 16328454; 16336219; 16368694; 16406470; 16439611; 16754659; 16874522; 16877267; 16902941; 16931638; 17272726; 17373692; 17415969; 17462859; 17540859; 17655760; 18073210; 18240029; 18249005; 18272392; 18282687; 18317461; 18322150; 18385290; 18454168; 18577758; 18723515; 18790604; 19086053; 19156168; 19183167; 19404243; 19451648; 19753311; 19863190; 19874574; 19913121; 19927300; 20133736; 20146726; 20201926; 20237496; 20467438; 20602615; 20628086; 21203415; 21605442; 21685390; 22117071; 22146060; 22338582; 22391213; 22450048; 22571431; 22865467; 22990911; 23147108; 23423139; 23455440; 23460876; 23604140; 23678982
description: cholinergic receptor, muscarinic 1
database cross reference: Ensembl:ENSG00000168539
database cross reference: HGNC:1950
database cross reference: HPRD:00338
database cross reference: MIM:118510
database cross reference: Vega:OTTHUMG00000167765

CHRNA4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BFNC
alternative term: EBN
alternative term: EBN1
alternative term: NACHR
alternative term: NACHRA4
alternative term: NACRA4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CHRNA4
full name from nomenclature authority: cholinergic receptor, nicotinic, alpha 4 (neuronal)
NCBI GeneID: 1137
gene map location: 20q13.33
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001508 (EC: ISS); GO_0001666 (EC: IDA, PMID: 12189247); GO_0004889 (EC: IDA, PMID: 8906617); GO_0004889 (EC: TAS); GO_0005886 (EC: ISS); GO_0005886 (EC: TAS); GO_0005892 (EC: IDA, PMID: 8906617); GO_0006281 (EC: IMP, PMID: 16332175); GO_0006811 (EC: NAS, PMID: 8906617); GO_0006816 (EC: ISS); GO_0006979 (EC: IMP, PMID: 16332175); GO_0007165 (EC: IDA, PMID: 8906617); GO_0007268 (EC: NAS, PMID: 7550350); GO_0007268 (EC: TAS); GO_0007271 (EC: ISS); GO_0007585 (EC: IEA); GO_0007626 (EC: IEA); GO_0009897 (EC: ISS); GO_0014059 (EC: ISS); GO_0015276 (EC: TAS); GO_0015464 (EC: IDA, PMID: 8906617); GO_0016020 (EC: ISS); GO_0016021 (EC: NAS, PMID: 8906617); GO_0019233 (EC: ISS); GO_0030054 (EC: IEA); GO_0030425 (EC: ISS); GO_0034220 (EC: TAS); GO_0035094 (EC: IDA, PMID: 12189247); GO_0035095 (EC: IMP, PMID: 17955458); GO_0035640 (EC: IEA); GO_0042113 (EC: ISS); GO_0042166 (EC: IC, PMID: 8906617); GO_0042391 (EC: ISS); GO_0043025 (EC: ISS); GO_0045211 (EC: IEA); GO_0050877 (EC: IMP, PMID: 17613539); GO_0050890 (EC: IMP, PMID: 14623738); GO_0051899 (EC: ISS); GO_0060080 (EC: ISS)
has PubMed association: PMID: 1492743; 1505988; 2351675; 7550350; 7647781; 7721089; 7806245; 8833159; 8889548; 8906617; 8987816; 9009220; 10563623; 11261808; 11352901; 11409698; 11771745; 11780052; 12121305; 12185808; 12189247; 12202488; 12214130; 12477932; 12556914; 12565129; 12663058; 12681012; 12781587; 12782394; 12887442; 12887446; 14623738; 15046869; 15154117; 15717291; 15790597; 15902904; 15944128; 16023355; 16091357; 16174636; 16183856; 16205844; 16238698; 16332175; 16344560; 16407231; 16456787; 16608406; 16636791; 16825297; 16869227; 17226798; 17373692; 17385675; 17488453; 17504247; 17559419; 17590520; 17613539; 17768273; 17948872; 17955458; 17977823; 17981562; 18042647; 18043764; 18226955; 18298895; 18534558; 18691652; 18762859; 18821565; 18937294; 18991851; 19016604; 19020039; 19058789; 19058950; 19059502; 19063970; 19101612; 19156168; 19259974; 19290018; 19300482; 19336370; 19352218; 19429020; 19482438; 19484724; 19498063; 19506906; 19577488; 19620239; 19628475; 19693267; 19698703; 19803686; 19874574; 19896235; 20189461; 20201926; 20231857; 20301348; 20331911; 20493238; 20584212; 20634891; 20649589; 20734064; 20736995; 20881005; 20943775; 21130611; 21203548; 21252231; 21321393; 21343288; 21396349; 21432576; 21445957; 21451042; 21500914; 21593077; 21683344; 21740768; 21753767; 21757735; 21821135; 21900206; 22008229; 22103306; 22118295; 22119468; 22253823; 22359659; 22373960; 22553201; 22722381; 22760121; 22873564; 22947540; 23000369; 23240931; 23349463; 23350800; 23429692; 23437071; 23553665; 23734673; 23843950; 24327142; 24385388
description: cholinergic receptor, nicotinic, alpha 4 (neuronal)
database cross reference: Ensembl:ENSG00000101204
database cross reference: HGNC:1958
database cross reference: HPRD:00333
database cross reference: MIM:118504
database cross reference: Vega:OTTHUMG00000033080

CHRNA7
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CHRNA7-2
alternative term: NACHRA7
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CHRNA7
full name from nomenclature authority: cholinergic receptor, nicotinic, alpha 7 (neuronal)
NCBI GeneID: 1139
gene map location: 15q14
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: IDA, PMID: 10771023); GO_0001540 (EC: IPI, PMID: 10681545); GO_0001666 (EC: IDA, PMID: 12189247); GO_0001988 (EC: IEA); GO_0004889 (EC: IDA, PMID: 12508119); GO_0005737 (EC: IEA); GO_0005886 (EC: IDA, PMID: 12508119); GO_0005886 (EC: TAS); GO_0005892 (EC: IDA, PMID: 8906617); GO_0006811 (EC: NAS, PMID: 8906617); GO_0006816 (EC: IDA, PMID: 8145738); GO_0006816 (EC: IMP, PMID: 10771023); GO_0006874 (EC: IMP, PMID: 16280133); GO_0006897 (EC: IEA); GO_0007165 (EC: IDA, PMID: 8906617); GO_0007268 (EC: TAS); GO_0007271 (EC: IEA); GO_0007613 (EC: NAS, PMID: 10681545); GO_0008144 (EC: IEA); GO_0008179 (EC: IEA); GO_0008284 (EC: IMP, PMID: 16280133); GO_0008306 (EC: IEA); GO_0009897 (EC: IEA); GO_0014061 (EC: IEA); GO_0014069 (EC: IEA); GO_0015464 (EC: IDA, PMID: 8906617); GO_0015643 (EC: IDA, PMID: 12508119); GO_0016021 (EC: NAS, PMID: 8145738); GO_0016324 (EC: IEA); GO_0017081 (EC: IDA, PMID: 8145738); GO_0019228 (EC: IEA); GO_0019901 (EC: IEA); GO_0030054 (EC: IEA); GO_0030317 (EC: IEA); GO_0030424 (EC: IEA); GO_0030426 (EC: IEA); GO_0032094 (EC: IEA); GO_0032225 (EC: IEA); GO_0032279 (EC: IEA); GO_0032691 (EC: IEA); GO_0032715 (EC: IEA); GO_0032720 (EC: IDA, PMID: 12508119); GO_0032720 (EC: IMP, PMID: 12508119); GO_0035094 (EC: IDA, PMID: 12189247); GO_0035095 (EC: IEA); GO_0042110 (EC: IEA); GO_0042113 (EC: IEA); GO_0042166 (EC: IDA, PMID: 8145738); GO_0042416 (EC: IEA); GO_0042734 (EC: IEA); GO_0042803 (EC: IDA, PMID: 8145738); GO_0043025 (EC: IEA); GO_0043197 (EC: IEA); GO_0043198 (EC: IEA); GO_0045121 (EC: IEA); GO_0045211 (EC: IEA); GO_0045766 (EC: IMP, PMID: 12189247); GO_0048149 (EC: IEA); GO_0050728 (EC: IEA); GO_0050890 (EC: IMP, PMID: 16754836); GO_0050890 (EC: NAS, PMID: 10681545); GO_0051117 (EC: IEA); GO_0060112 (EC: IEA); GO_0097110 (EC: IEA)
has PubMed association: PMID: 7571003; 8145738; 8188270; 8889549; 8906617; 8996215; 9009220; 9193799; 9782083; 10206225; 10206240; 10336173; 10681545; 10771023; 11150893; 11278378; 11424985; 11455129; 11532536; 11771745; 11803512; 11803513; 11829490; 11840317; 11840567; 11891308; 11891309; 11905992; 12020960; 12049804; 12189247; 12193385; 12214130; 12391028; 12399955; 12431773; 12454998; 12470124; 12477932; 12508119; 12509811; 12549904; 12626641; 12663058; 12748066; 12781587; 12783266; 14569275; 14582144; 14729237; 15046869; 15100704; 15219869; 15226316; 15252450; 15292665; 15465084; 15494367; 15504725; 15531077; 15807899; 15857954; 15896732; 15927954; 16280133; 16307758; 16314871; 16344560; 16417613; 16461803; 16563701; 16754836; 16822928; 16837119; 17012261; 17012698; 17015027; 17113175; 17192639; 17192651; 17241116; 17286584; 17291692; 17335853; 17373692; 17493709; 17498763; 17504249; 17559419; 17573436; 17709503; 17884806; 17920082; 17978319; 17981562; 18057084; 18071042; 18072279; 18073210; 18078695; 18198266; 18302933; 18307030; 18385739; 18387948; 18393235; 18450646; 18471073; 18545269; 18667281; 18691158; 18696274; 18800618; 18854154; 19038445; 19040571; 19058789; 19059502; 19080531; 19086053; 19136953; 19156168; 19181484; 19259974; 19307444; 19351547; 19367581; 19433665; 19462340; 19506073; 19549780; 19587288; 19623583; 19630919; 19631623; 19666073; 19736351; 19808646; 19896235; 19944766; 20006992; 20231857; 20236110; 20309583; 20463630; 20506139; 20518839; 20584212; 20602615; 20660165; 20691427; 20708605; 20720594; 20728875; 20734064; 20736995; 20864676; 20927308; 21047781; 21051662; 21062106; 21073885; 21390272; 21510634; 21550667; 21610071; 21630219; 21718690; 21790533; 21840925; 21861625; 21969082; 21979958; 22009746; 22031302; 22040696; 22052086; 22084248; 22253823; 22270376; 22300029; 22300033; 22336089; 22342972; 22359659; 22420046; 22420048; 22423106; 22441542; 22483691; 22553201; 22556416; 22577141; 22588665; 22614008; 22775350; 22981153; 23022323; 23275563; 23324234; 233…
description: cholinergic receptor, nicotinic, alpha 7 (neuronal)
database cross reference: HGNC:1960
database cross reference: HPRD:00339
database cross reference: MIM:118511

CHRNB2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: EFNL3
alternative term: nAChRB2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CHRNB2
full name from nomenclature authority: cholinergic receptor, nicotinic, beta 2 (neuronal)
NCBI GeneID: 1141
NCBI LocusTag: RP11-61L14.4
gene map location: 1q21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001508 (EC: IEA); GO_0001661 (EC: IEA); GO_0001666 (EC: IDA, PMID: 12189247); GO_0004889 (EC: IDA, PMID: 8906617); GO_0004889 (EC: TAS); GO_0005886 (EC: TAS); GO_0005892 (EC: IDA, PMID: 8906617); GO_0006811 (EC: NAS, PMID: 8906617); GO_0006816 (EC: ISS); GO_0006939 (EC: ISS); GO_0007165 (EC: IDA, PMID: 8906617); GO_0007268 (EC: TAS); GO_0007271 (EC: ISS); GO_0007601 (EC: ISS); GO_0007605 (EC: ISS); GO_0007612 (EC: IMP, PMID: 15964197); GO_0007613 (EC: IMP, PMID: 15964197); GO_0007626 (EC: ISS); GO_0008144 (EC: IEA); GO_0008306 (EC: ISS); GO_0008542 (EC: IMP, PMID: 15964197); GO_0009897 (EC: ISS); GO_0014059 (EC: ISS); GO_0015276 (EC: TAS); GO_0015464 (EC: IDA, PMID: 8906617); GO_0016021 (EC: NAS, PMID: 8906617); GO_0019233 (EC: ISS); GO_0021562 (EC: ISS); GO_0021631 (EC: ISS); GO_0021771 (EC: ISS); GO_0021952 (EC: ISS); GO_0030054 (EC: IEA); GO_0030890 (EC: ISS); GO_0032225 (EC: ISS); GO_0032226 (EC: IEA); GO_0033603 (EC: ISS); GO_0034220 (EC: TAS); GO_0035094 (EC: IDA, PMID: 12189247); GO_0035095 (EC: IMP, PMID: 17559419); GO_0035176 (EC: ISS); GO_0042053 (EC: ISS); GO_0042113 (EC: ISS); GO_0042166 (EC: IC, PMID: 8906617); GO_0042166 (EC: IMP, PMID: 15964197); GO_0042220 (EC: ISS); GO_0042320 (EC: ISS); GO_0045188 (EC: IEA); GO_0045211 (EC: IEA); GO_0045471 (EC: ISS); GO_0045759 (EC: ISS); GO_0048814 (EC: ISS); GO_0050877 (EC: IMP, PMID: 17900292); GO_0050890 (EC: IMP, PMID: 17559419); GO_0051291 (EC: IEA); GO_0051899 (EC: ISS); GO_0051963 (EC: ISS); GO_0060084 (EC: ISS)
has PubMed association: PMID: 1397297; 1505988; 2377478; 8906617; 8987816; 9009220; 9921897; 10441742; 10771020; 11054772; 11062464; 11104662; 11261808; 11771745; 11906688; 11952766; 12185808; 12189247; 12202488; 12214130; 12477932; 12663058; 12681012; 15026168; 15033200; 15046869; 15154117; 15489334; 15681842; 15944128; 15964197; 16023355; 16174636; 16183856; 16238698; 16314871; 16407231; 16636791; 16928859; 17192785; 17226798; 17373692; 17385675; 17559419; 17900292; 18043764; 18226955; 18242781; 18534558; 18534914; 18593715; 18762859; 18830724; 18991851; 19058950; 19059502; 19063970; 19086053; 19101612; 19156168; 19259974; 19279256; 19482438; 19620239; 19755656; 19874574; 20231857; 20301348; 20371741; 20413850; 20441771; 20534741; 20574532; 20603624; 20649589; 20677014; 20734064; 20736995; 20854418; 20880607; 20881005; 20923852; 20943775; 21252231; 21287502; 21396349; 21451042; 21536845; 21606948; 21757735; 22359659; 22553201; 23000369; 23429692; 23437071; 23734673
description: cholinergic receptor, nicotinic, beta 2 (neuronal)
database cross reference: Ensembl:ENSG00000160716
database cross reference: HGNC:1962
database cross reference: HPRD:00335
database cross reference: MIM:118507
database cross reference: Vega:OTTHUMG00000037262

CHRNB4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CHRNB4
full name from nomenclature authority: cholinergic receptor, nicotinic, beta 4 (neuronal)
NCBI GeneID: 1143
NCBI LocusTag: hCG_1731645
gene map location: 15q24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001508 (EC: IEA); GO_0004889 (EC: TAS, PMID: 11742001); GO_0005886 (EC: TAS); GO_0005887 (EC: IC, PMID: 11742001); GO_0005892 (EC: IDA, PMID: 8906617); GO_0005892 (EC: TAS, PMID: 11742001); GO_0006811 (EC: TAS, PMID: 8906617); GO_0006812 (EC: TAS, PMID: 11742001); GO_0006939 (EC: IEA); GO_0006940 (EC: IEA); GO_0007165 (EC: IDA, PMID: 8906617); GO_0007268 (EC: TAS); GO_0007271 (EC: TAS, PMID: 1330682); GO_0007626 (EC: IEA); GO_0015276 (EC: TAS); GO_0015464 (EC: IDA, PMID: 8906617); GO_0016021 (EC: NAS, PMID: 8906617); GO_0030054 (EC: IEA); GO_0034220 (EC: TAS); GO_0035095 (EC: IEA); GO_0045211 (EC: IEA); GO_0046928 (EC: NAS, PMID: 11742001); GO_0060084 (EC: IMP, PMID: 11450844)
has PubMed association: PMID: 1330682; 1505988; 1572664; 1689727; 1725184; 2004777; 7571003; 8906617; 8987816; 8996215; 9009220; 9193799; 9203638; 9655874; 9693793; 10336173; 11118490; 11181995; 11450844; 11606319; 11742001; 12150770; 12477932; 12663058; 12783266; 12912995; 15489334; 15742216; 16091357; 16826524; 17373692; 18163978; 18385738; 18385739; 18414406; 18519524; 18618000; 18759969; 18780872; 18996504; 19029397; 19059502; 19086053; 19156168; 19259974; 19429911; 19628475; 19628476; 19671882; 19696770; 19706762; 19859904; 20201926; 20418889; 20426799; 20485328; 20554942; 20584212; 20587604; 20631687; 20685379; 20734064; 20736995; 20808433; 20886544; 21107856; 21168125; 21228559; 21248747; 21343288; 21436384; 21486776; 21646606; 21658281; 21747048; 21917987; 22024278; 22042234; 22042774; 22101982; 22241830; 22336398; 22382680; 22382757; 22438940; 22459873; 22543065; 22945651; 22956269; 23029550; 23061658; 23143843; 23349463; 23458267; 23626818; 23691088; 23729684; 23844051; 23884938; 24085295
description: cholinergic receptor, nicotinic, beta 4 (neuronal)

CLU
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
subclass of: Restriction
  on property: molecularly interacts with
  some values from: amyloid-beta
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APO-J
alternative term: APOJ
alternative term: CLI
alternative term: CLU1
alternative term: CLU2
alternative term: KUB1
alternative term: NA1/NA2
alternative term: SGP-2
alternative term: SGP2
alternative term: SP-40
alternative term: TRPM-2
alternative term: TRPM2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CLU
full name from nomenclature authority: clusterin
NCBI GeneID: 1191
NCBI LocusTag: AAG4
gene map location: 8p21-p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001836 (EC: IC, PMID: 16113678); GO_0002576 (EC: TAS); GO_0005515 (EC: IPI, PMID: 16113678); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 11123922); GO_0005634 (EC: IEA); GO_0005739 (EC: IDA, PMID: 16113678); GO_0005783 (EC: IEA); GO_0005829 (EC: IEA); GO_0006629 (EC: NAS, PMID: 2387851); GO_0006956 (EC: TAS, PMID: 1585460); GO_0006958 (EC: IEA); GO_0007596 (EC: TAS); GO_0009615 (EC: IEP, PMID: 16548883); GO_0016887 (EC: IDA, Qualifier: NOT, PMID: 11123922); GO_0030168 (EC: TAS); GO_0031012 (EC: IDA, Qualifier: colocalizes_with); GO_0031093 (EC: TAS); GO_0031625 (EC: IDA); GO_0031966 (EC: IEA); GO_0032436 (EC: IMP); GO_0032463 (EC: IMP, PMID: 16113678); GO_0034366 (EC: IDA, PMID: 16682745); GO_0042583 (EC: IEA); GO_0043065 (EC: IMP); GO_0043691 (EC: TAS, PMID: 16682745); GO_0045087 (EC: IEA); GO_0048471 (EC: IDA); GO_0050821 (EC: IDA, PMID: 11123922); GO_0051092 (EC: IMP); GO_0051787 (EC: IDA, PMID: 11123922); GO_0051787 (EC: IPI, PMID: 19996109); GO_0051788 (EC: IDA, PMID: 19996109); GO_0061077 (EC: IDA, PMID: 11123922); GO_0070062 (EC: IDA, PMID: 19056867); GO_0072562 (EC: IDA); GO_0097193 (EC: IDA); GO_1902230 (EC: IMP, PMID: 16113678); GO_2000060 (EC: IMP); GO_2001244 (EC: IMP)
has PubMed association: PMID: 1424805; 1491011; 1551440; 1585460; 1903064; 1924317; 1974459; 2185274; 2387851; 2454950; 2601725; 2721499; 2780565; 2780570; 3154963; 3167096; 7615015; 7626703; 7768901; 8181474; 8292612; 8314591; 8328966; 8345200; 8387101; 8555189; 8634259; 8752142; 8759347; 8843912; 8889548; 9228033; 9336835; 9537999; 10066740; 10219089; 10329371; 10694874; 11123922; 11186422; 11570883; 11714447; 11795992; 11813210; 11892985; 11904161; 11906815; 12082621; 12172907; 12176985; 12200037; 12393179; 12427144; 12429802; 12470829; 12477932; 12551933; 12679903; 12754519; 12824284; 12860995; 12867999; 12882985; 14618611; 14630798; 14702039; 14718574; 14760718; 15033782; 15133840; 15146195; 15158456; 15174051; 15247015; 15252304; 15304052; 15342556; 15389725; 15480429; 15489334; 15492264; 15499376; 15538973; 15591223; 15649646; 15689620; 15791650; 15809754; 15883054; 15925890; 15929184; 15955107; 16113678; 16179938; 16263699; 16331665; 16335952; 16421571; 16464517; 16490286; 16548883; 16675913; 16682745; 16709604; 16709934; 16740002; 16775601; 16806233; 16955214; 17043677; 17048076; 17056579; 17080454; 17148459; 17170699; 17203891; 17224269; 17260971; 17322305; 17407782; 17412999; 17420006; 17451556; 17512083; 17534116; 17535098; 17689225; 17855704; 17872975; 17974975; 18079682; 18082619; 18097679; 18239862; 18378577; 18458059; 18514801; 18542050; 18612545; 18624398; 18649357; 18709641; 18712185; 18714397; 18786636; 18806885; 18813793; 18842294; 19056867; 19118032; 19137541; 19165232; 19166932; 19177010; 19182256; 19220628; 19264665; 19289586; 19344414; 19353783; 19357365; 19391138; 19413638; 19446882; 19535339; 19542874; 19651157; 19664600; 19734902; 19734903; 19757199; 19793084; 19814590; 19878569; 19878770; 19878774; 19879420; 19879421; 19879422; 19879423; 19903339; 19903745; 19935703; 19940549; 19996109; 20000738; 20007348; 20009887; 20019877; 20028970; 20057494; 20058210; 20068069; 20096688; 20195357; 20209083; 20353268; 20360068; 20410100; 20460622; 20497247; 20534741; 20554627…
description: clusterin
relation: Alzpathway: AmyloidB-CLU dissociation; AmyloidB-CLU association_Brain; AmyloidB-CLU leading to Unknown transportation. Source: https://pubmed.ncbi.nlm.nih.gov/30872998/
database cross reference: Ensembl:ENSG00000120885
database cross reference: HGNC:2095
database cross reference: HPRD:01706
database cross reference: MIM:185430
database cross reference: Vega:OTTHUMG00000102114

CCR1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD191
alternative term: CKR-1
alternative term: CKR1
alternative term: CMKBR1
alternative term: HM145
alternative term: MIP1aR
alternative term: SCYAR1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCR1
full name from nomenclature authority: chemokine (C-C motif) receptor 1
NCBI GeneID: 1230
gene map location: 3p21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002407 (EC: TAS, PMID: 16621978); GO_0004435 (EC: IDA, PMID: 10734056); GO_0004950 (EC: IDA, PMID: 10660125); GO_0005515 (EC: IPI, PMID: 15001559); GO_0005886 (EC: IDA, PMID: 10660125); GO_0005886 (EC: IMP, PMID: 15001559); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 7505609); GO_0006816 (EC: IDA, PMID: 10734056); GO_0006874 (EC: IDA, PMID: 10734056); GO_0006887 (EC: IDA, PMID: 10734056); GO_0006935 (EC: NAS, PMID: 15474493); GO_0006954 (EC: IEA); GO_0006955 (EC: IDA, PMID: 10734056); GO_0007155 (EC: TAS, PMID: 10910894); GO_0007166 (EC: TAS, PMID: 10770925); GO_0007187 (EC: TAS, PMID: 7505609); GO_0007204 (EC: IDA, PMID: 10734056); GO_0007267 (EC: IDA, PMID: 10734056); GO_0008152 (EC: IDA, PMID: 10734056); GO_0009611 (EC: TAS, PMID: 7505609); GO_0009897 (EC: IDA, PMID: 10706735); GO_0010629 (EC: IMP); GO_0016493 (EC: IDA, PMID: 10734056); GO_0019221 (EC: NAS, PMID: 15474493); GO_0019957 (EC: IPI, PMID: 10660125); GO_0030502 (EC: IMP); GO_0035717 (EC: IPI, PMID: 10660125); GO_0045672 (EC: IMP); GO_0051928 (EC: IDA, PMID: 15764707); GO_0070098 (EC: IDA); GO_0070374 (EC: IMP); GO_0071791 (EC: IPI, PMID: 10660125); GO_0090026 (EC: IDA, PMID: 18587271)
has PubMed association: PMID: 2834384; 7505609; 7545673; 7594543; 7679328; 7683036; 8011297; 8530354; 8626727; 8631787; 8699119; 9115216; 9143512; 9289016; 9346309; 9558365; 9886417; 10094132; 10202040; 10583963; 10660125; 10702689; 10706735; 10734056; 10770925; 10910894; 11085751; 11110672; 11116158; 11449371; 11470772; 11804551; 11832479; 11920567; 12070001; 12085329; 12270118; 12477932; 12651617; 12763925; 12794150; 14530297; 14595653; 14637022; 14674010; 15001559; 15039444; 15053339; 15103513; 15265234; 15337751; 15474493; 15489334; 15548526; 15764707; 15927850; 15950672; 16182378; 16226254; 16323127; 16621978; 16837468; 16969502; 17135764; 17192849; 17298994; 17336272; 17389578; 17464174; 17558413; 17914560; 18178867; 18240029; 18311140; 18559339; 18577758; 18587271; 18972130; 19017998; 19423540; 19553544; 19603542; 19664396; 19687291; 19693089; 19913121; 20015385; 20056178; 20086017; 20154287; 20190752; 20406964; 20429924; 20438785; 20628086; 20634891; 20802378; 20921899; 21148810; 21942940; 22007486; 22104149; 22650026; 22727097; 22829007; 22842622; 23054685; 23125416; 23217400; 23219091; 23233369; 23276697; 23291587; 24056371
description: chemokine (C-C motif) receptor 1
database cross reference: Ensembl:ENSG00000163823
database cross reference: HGNC:1602
database cross reference: HPRD:03101
database cross reference: MIM:601159
database cross reference: Vega:OTTHUMG00000133451

CCR3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CC-CKR-3
alternative term: CD193
alternative term: CKR3
alternative term: CMKBR3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCR3
full name from nomenclature authority: chemokine (C-C motif) receptor 3
NCBI GeneID: 1232
gene map location: 3p21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001938 (EC: IEA); GO_0004950 (EC: TAS, PMID: 10415069); GO_0005515 (EC: IPI); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 9302298); GO_0006935 (EC: IEA); GO_0006954 (EC: IEA); GO_0006968 (EC: TAS, PMID: 10713092); GO_0007155 (EC: TAS, PMID: 10201960); GO_0007188 (EC: TAS, PMID: 10201960); GO_0007204 (EC: TAS, PMID: 9302298); GO_0016032 (EC: IEA); GO_0016493 (EC: IEA); GO_0045766 (EC: IMP, PMID: 19525930); GO_0070098 (EC: TAS, PMID: 10415069)
has PubMed association: PMID: 7594543; 7622448; 8609214; 8631813; 8631926; 8642344; 8674119; 8676064; 8884276; 9005985; 9024664; 9143512; 9182688; 9252350; 9289016; 9302298; 9346309; 9359702; 9419219; 9573273; 9636210; 9653051; 9712872; 9736741; 9765440; 9789057; 10094132; 10201960; 10415069; 10488147; 10514402; 10527858; 10590105; 10642580; 10666479; 10713092; 10877489; 10900353; 10975800; 11001881; 11085751; 11110785; 11115360; 11120849; 11149986; 11196669; 11307756; 11396683; 11449371; 11832479; 11920572; 11991282; 11994538; 12023397; 12079287; 12149192; 12218106; 12393570; 12397598; 12477932; 12654630; 12794150; 12884299; 12902471; 14581140; 14647058; 14702039; 14733956; 15053339; 15086398; 15194768; 15219825; 15476879; 15489334; 15507393; 15580493; 15607028; 15807893; 15857508; 15992849; 16081847; 16174786; 16470129; 16631222; 16712896; 16904155; 16920975; 17041228; 17135764; 17146638; 17672867; 17703412; 17845580; 17983872; 18240029; 18244953; 18311140; 18379861; 18577758; 18636124; 18676680; 18805825; 18974840; 19017998; 19028820; 19131662; 19170196; 19218218; 19247692; 19258923; 19414538; 19423540; 19525930; 19526283; 19542083; 19553323; 19559392; 19625176; 19692168; 19693089; 19714638; 19731977; 20022477; 20056178; 20144207; 20190752; 20220260; 20237496; 20306659; 20364559; 20380698; 20406964; 20438785; 20503287; 20505746; 20603037; 20647273; 20659406; 20726325; 20734064; 20921899; 20923436; 21041734; 21077277; 21143381; 21280323; 21406396; 21660963; 21735070; 21917937; 22086059; 22217447; 22702503; 22829007; 22842622; 23017229; 23054685; 23183094; 23251661; 23291587; 23566847; 23636060; 23643185; 23702389; 23742077; 23955446
description: chemokine (C-C motif) receptor 3
database cross reference: Ensembl:ENSG00000183625
database cross reference: HGNC:1604
database cross reference: HPRD:03167
database cross reference: MIM:601268
database cross reference: Vega:OTTHUMG00000133484

CCR4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CC-CKR-4
alternative term: CD194
alternative term: CKR4
alternative term: CMKBR4
alternative term: ChemR13
alternative term: HGCN:14099
alternative term: K5-5
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCR4
full name from nomenclature authority: chemokine (C-C motif) receptor 4
NCBI GeneID: 1233
gene map location: 3p24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001764 (EC: IEA); GO_0002507 (EC: IEA); GO_0004950 (EC: TAS, PMID: 7642634); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 7642634); GO_0006935 (EC: IEA); GO_0006954 (EC: IEA); GO_0006955 (EC: IEA); GO_0007204 (EC: TAS, PMID: 7642634); GO_0009314 (EC: IEA); GO_0009617 (EC: IEA); GO_0009897 (EC: IEA); GO_0016493 (EC: IEA); GO_0043025 (EC: IEA); GO_0046677 (EC: IEA); GO_0050927 (EC: IEA); GO_0070098 (EC: TAS, PMID: 7642634)
has PubMed association: PMID: 7642634; 8573157; 8884276; 9169480; 9430724; 9743322; 9933589; 10036181; 10466728; 10754297; 11196669; 11861261; 12070001; 12270118; 12406880; 12429730; 12456591; 12477932; 12485447; 12778466; 14657875; 15187160; 15202833; 15328188; 15489334; 15569983; 15621800; 15857508; 15955100; 17071491; 17117949; 17546636; 18071306; 18240029; 18577758; 18782672; 19106589; 19239991; 19244125; 19261691; 19374191; 19423540; 19903885; 19913121; 19942450; 20148806; 20164417; 20190752; 20237293; 20237496; 20334681; 20364559; 20406964; 20412707; 20438785; 20628086; 20963786; 21443538; 21525208; 21739422; 22490506; 22842622; 23180648; 23644599; 23731651; 24127572
description: chemokine (C-C motif) receptor 4
database cross reference: HGNC:1605
database cross reference: HPRD:05324
database cross reference: MIM:604836

CCR5
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CC-CKR-5
alternative term: CCCKR5
alternative term: CCR-5
alternative term: CD195
alternative term: CKR-5
alternative term: CKR5
alternative term: CMKBR5
alternative term: IDDM22
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCR5
full name from nomenclature authority: chemokine (C-C motif) receptor 5 (gene/pseudogene)
NCBI GeneID: 1234
gene map location: 3p21.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: IEP, PMID: 12032188); GO_0001974 (EC: IEA); GO_0002407 (EC: TAS, PMID: 16621978); GO_0003779 (EC: IDA, PMID: 12421915); GO_0004435 (EC: TAS, PMID: 8663314); GO_0004950 (EC: TAS, PMID: 10201901); GO_0005515 (EC: IPI, PMID: 12421915); GO_0005737 (EC: TAS, PMID: 10415069); GO_0005768 (EC: IDA, PMID: 10679098); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 10393923); GO_0006816 (EC: IDA, PMID: 8699119); GO_0006935 (EC: TAS, PMID: 10741397); GO_0006954 (EC: IEA); GO_0006955 (EC: IEA); GO_0006968 (EC: TAS, PMID: 10201901); GO_0007166 (EC: TAS, PMID: 8639485); GO_0007186 (EC: IMP, PMID: 19523456); GO_0007204 (EC: TAS, PMID: 10201901); GO_0007267 (EC: IDA, PMID: 10679098); GO_0009897 (EC: IDA, PMID: 10679098); GO_0009986 (EC: IDA, PMID: 10521508); GO_0014808 (EC: IDA, PMID: 19523456); GO_0015026 (EC: TAS, PMID: 10469138); GO_0016032 (EC: TAS); GO_0016493 (EC: IDA, PMID: 11278962); GO_0016493 (EC: NAS, PMID: 8639485); GO_0019722 (EC: IDA, PMID: 10679098); GO_0019957 (EC: IPI, PMID: 10679098); GO_0023052 (EC: IEP, PMID: 12032188); GO_0030260 (EC: TAS); GO_0070098 (EC: IDA, PMID: 11278962); GO_0070098 (EC: NAS, PMID: 8639485); GO_0070098 (EC: TAS, PMID: 10201901); GO_0070723 (EC: IMP, PMID: 19523456); GO_0071222 (EC: IEP, PMID: 10679098); GO_0071791 (EC: IPI, PMID: 8699119); GO_0090026 (EC: IEA)
has PubMed association: PMID: 2183196; 2564392; 2569467; 2834384; 3346208; 3512269; 3960725; 8639485; 8649511; 8649512; 8663314; 8674119; 8699119; 8751444; 8756719; 8805353; 8898753; 8906795; 8906796; 8976200; 8995603; 9020356; 9031325; 9143512; 9184207; 9188565; 9207783; 9256481; 9261346; 9261451; 9289016; 9334377; 9343222; 9353123; 9359654; 9359702; 9362541; 9388201; 9399903; 9420225; 9420238; 9445013; 9446638; 9468473; 9525683; 9576751; 9576954; 9632396; 9636210; 9653051; 9653130; 9765440; 9870313; 9882290; 9882373; 9890944; 9971818; 10029247; 10037796; 10085131; 10089882; 10200301; 10201901; 10229873; 10339592; 10357469; 10364178; 10370370; 10384144; 10393923; 10393974; 10413516; 10415069; 10438703; 10438870; 10446313; 10449282; 10453044; 10465086; 10469138; 10477567; 10477718; 10482561; 10482572; 10487781; 10497246; 10505675; 10521508; 10527688; 10544150; 10555208; 10559284; 10562492; 10574939; 10585143; 10590105; 10590121; 10602038; 10602409; 10606089; 10623731; 10640778; 10644351; 10679098; 10702689; 10725362; 10738970; 10741397; 10751368; 10758170; 10775626; 10801487; 10807185; 10816381; 10820198; 10823934; 10826481; 10872839; 10877489; 10882583; 10888615; 10888639; 10917742; 10938094; 10961858; 10970739; 10985308; 11005830; 11023492; 11023526; 11024154; 11069996; 11072599; 11085751; 11086073; 11115360; 11116158; 11118070; 11125885; 11125899; 11134270; 11141322; 11153675; 11162839; 11175286; 11177400; 11181160; 11188946; 11196681; 11196706; 11238869; 11263244; 11264152; 11264346; 11264367; 11265761; 11274729; 11278567; 11278738; 11278962; 11290759; 11312658; 11313374; 11334429; 11335892; 11336643; 11342415; 11350939; 11354628; 11356952; 11356961; 11356967; 11369664; 11377705; 11385319; 11390601; 11393656; 11397808; 11398114; 11403814; 11413305; 11414813; 11427892; 11429110; 11447384; 11448957; 11449371; 11464139; 11468147; 11470772; 11477473; 11484163; 11485305; 11485615; 11489906; 11500196; 11504955; 11511825; 11517394; 11529558; 11543895; 11559423; 11591716; 11595595; 11596075; 1…
description: chemokine (C-C motif) receptor 5 (gene/pseudogene)
database cross reference: Ensembl:ENSG00000160791
database cross reference: HGNC:1606
database cross reference: HPRD:03223
database cross reference: MIM:601373
database cross reference: Vega:OTTHUMG00000133481

CCR6
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BN-1
alternative term: C-C CKR-6
alternative term: CC-CKR-6
alternative term: CCR-6
alternative term: CD196
alternative term: CKR-L3
alternative term: CKRL3
alternative term: CMKBR6
alternative term: DCR2
alternative term: DRY6
alternative term: GPR29
alternative term: GPRCY4
alternative term: STRL22
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCR6
full name from nomenclature authority: chemokine (C-C motif) receptor 6
NCBI GeneID: 1235
gene map location: 6q27
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002407 (EC: TAS, PMID: 16621978); GO_0004872 (EC: TAS, PMID: 9186513); GO_0004950 (EC: TAS, PMID: 11001880); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 9186513); GO_0006928 (EC: TAS, PMID: 9186513); GO_0006935 (EC: TAS, PMID: 11001880); GO_0006955 (EC: TAS, PMID: 9223454); GO_0006959 (EC: TAS, PMID: 11001880); GO_0006968 (EC: TAS, PMID: 10521347); GO_0007165 (EC: TAS, PMID: 9186513); GO_0007204 (EC: TAS, PMID: 9223454); GO_0016493 (EC: IEA); GO_0045087 (EC: TAS); GO_0070098 (EC: TAS, PMID: 11001880)
has PubMed association: PMID: 2834384; 8125298; 8886020; 9070937; 9169459; 9186513; 9223454; 9294137; 9294138; 10521347; 11001880; 11164896; 11714836; 11751947; 11994436; 12067311; 12070001; 12081481; 12149255; 12193700; 12477932; 12514792; 12642342; 14574404; 15483227; 15489334; 15591779; 15701269; 15972662; 16095490; 16215992; 16344560; 16621978; 16622267; 16641550; 17075975; 17133360; 17171755; 17562763; 17615381; 18097022; 18218038; 18240029; 18465142; 18577758; 18587394; 18703490; 19233848; 19249008; 19305396; 19324905; 19423540; 19492413; 19539215; 19760754; 19811428; 20022113; 20023216; 20056178; 20068036; 20194631; 20220766; 20334681; 20379614; 20406964; 20438785; 20439195; 20453841; 20453842; 20459729; 20483750; 20511548; 20526339; 20526340; 20570966; 20634891; 20720211; 20872189; 21072187; 21092675; 21102463; 21228329; 21261017; 21300824; 21398606; 21624121; 21724701; 21763254; 21873313; 21912453; 21935436; 21937703; 21949768; 21984702; 22079021; 22092173; 22269120; 22490506; 22732549; 22796894; 22842622; 22859539; 22926920; 23128233; 23306142; 23599932; 23681234; 23758411; 23765988; 23790181; 23850713; 23935994; 23983073
description: chemokine (C-C motif) receptor 6
database cross reference: Ensembl:ENSG00000112486
database cross reference: HGNC:1607
database cross reference: HPRD:03498
database cross reference: MIM:601835
database cross reference: Vega:OTTHUMG00000016015

CCR7
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BLR2
alternative term: CD197
alternative term: CDw197
alternative term: CMKBR7
alternative term: EBI1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCR7
full name from nomenclature authority: chemokine (C-C motif) receptor 7
NCBI GeneID: 1236
gene map location: 17q12-q21.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001768 (EC: IC, PMID: 12729902); GO_0001954 (EC: IC, PMID: 15569314); GO_0002407 (EC: IC, PMID: 15778365); GO_0002408 (EC: IC, PMID: 14592837); GO_0002606 (EC: ISS); GO_0002885 (EC: ISS); GO_0002922 (EC: ISS); GO_0004930 (EC: TAS, PMID: 16621978); GO_0005622 (EC: IDA); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0006954 (EC: NAS, PMID: 14592837); GO_0006955 (EC: IEA); GO_0007186 (EC: TAS, PMID: 16621978); GO_0007204 (EC: TAS, PMID: 9153236); GO_0009897 (EC: IEA); GO_0016021 (EC: IEA); GO_0016493 (EC: ISS); GO_0030838 (EC: IC, PMID: 11242036); GO_0031274 (EC: IC, PMID: 11242036); GO_0031529 (EC: IC, PMID: 15569314); GO_0032496 (EC: IEA); GO_0032649 (EC: ISS); GO_0032735 (EC: ISS); GO_0032862 (EC: IC, PMID: 15778365); GO_0034695 (EC: IC, PMID: 14592837); GO_0035757 (EC: IPI, PMID: 9507024); GO_0035758 (EC: IPI, PMID: 9507024); GO_0038115 (EC: IDA, PMID: 9507024); GO_0038116 (EC: IDA, PMID: 9507024); GO_0038117 (EC: IDA, PMID: 9507024); GO_0038121 (EC: IDA, PMID: 9507024); GO_0043123 (EC: IC, PMID: 15059845); GO_0043552 (EC: IC, PMID: 15059845); GO_0045060 (EC: IEA); GO_0045785 (EC: IC, PMID: 15569314); GO_0045860 (EC: IC, PMID: 14592837); GO_0046330 (EC: IC, PMID: 15778365); GO_0050706 (EC: ISS); GO_0050862 (EC: IEA); GO_0051209 (EC: IC, PMID: 14592837); GO_0051491 (EC: IC, PMID: 15569314); GO_0051897 (EC: IC, PMID: 15059845); GO_0070098 (EC: ISS); GO_0070374 (EC: IC, PMID: 12729902); GO_0071731 (EC: IC, PMID: 16249377); GO_0072610 (EC: ISS); GO_0090023 (EC: IDA); GO_0097022 (EC: TAS, PMID: 18379575); GO_0097029 (EC: ISS); GO_2000107 (EC: IC, PMID: 15059845); GO_2000147 (EC: IC, PMID: 15778365); GO_2000510 (EC: ISS); GO_2000522 (EC: ISS); GO_2000525 (EC: ISS); GO_2000526 (EC: ISS); GO_2000547 (EC: ISS)
has PubMed association: PMID: 2834384; 7488016; 7851893; 8383238; 8889548; 9153236; 9507024; 9585422; 9725259; 9743376; 10607681; 10706668; 10741397; 10861057; 11145663; 11242036; 11359797; 11507220; 11830455; 11861876; 11929789; 11970971; 12023337; 12070001; 12149218; 12477932; 12486098; 12642342; 12673677; 12729902; 12799021; 12851649; 14592837; 14990723; 15034011; 15040017; 15059845; 15073111; 15122702; 15247147; 15265234; 15284247; 15304089; 15489334; 15569314; 15674360; 15743472; 15753377; 15778365; 15867478; 15950936; 15972662; 16115904; 16223574; 16225771; 16249377; 16272303; 16278001; 16278374; 16278415; 16344560; 16494043; 16500130; 16621978; 16690519; 16786131; 16802356; 16857986; 16887149; 17006331; 17032700; 17178876; 17192395; 17431094; 17440035; 17587445; 17687340; 17890452; 18065728; 18166500; 18235009; 18240029; 18310327; 18319253; 18379575; 18437055; 18497951; 18544997; 18577758; 18623114; 18664492; 18696160; 18802075; 19068542; 19074885; 19087620; 19136936; 19196101; 19287948; 19423540; 19513547; 19536265; 19536742; 19540558; 19585516; 19615795; 19731977; 19749090; 19862774; 20029460; 20036791; 20056178; 20150960; 20237496; 20406964; 20438785; 20439195; 20651394; 20811680; 20855251; 20889506; 20889923; 21048031; 21071608; 21081040; 21092675; 21165563; 21165582; 21261017; 21347514; 21464944; 21548969; 21624121; 21680174; 21698152; 21731495; 21735098; 21739164; 21739671; 21953548; 22020953; 22043010; 22158872; 22163030; 22221265; 22251626; 22334704; 22350183; 22438908; 22498742; 22533989; 22619482; 22634622; 22659045; 22718198; 22797918; 22821963; 22842622; 22923218; 22990666; 23028633; 23290307; 23363813; 23449735; 23469143; 23498789; 23519840; 23747721; 23888080; 23922113; 24052640; 24136650; 24138884; 24311382
description: chemokine (C-C motif) receptor 7
database cross reference: Ensembl:ENSG00000126353
database cross reference: HGNC:1608
database cross reference: HPRD:02588
database cross reference: MIM:600242
database cross reference: Vega:OTTHUMG00000133375

CCR8
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CC-CKR-8
alternative term: CCR-8
alternative term: CDw198
alternative term: CKRL1
alternative term: CMKBR8
alternative term: CMKBRL2
alternative term: CY6
alternative term: GPRCY6
alternative term: TER1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCR8
full name from nomenclature authority: chemokine (C-C motif) receptor 8
NCBI GeneID: 1237
gene map location: 3p22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004950 (EC: TAS, PMID: 9417093); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 8816377); GO_0006935 (EC: IEA); GO_0006955 (EC: IEA); GO_0007155 (EC: TAS, PMID: 10910894); GO_0007186 (EC: TAS, PMID: 8816377); GO_0007204 (EC: IEA); GO_0015026 (EC: TAS, PMID: 9417093); GO_0016493 (EC: IEA); GO_0070098 (EC: TAS, PMID: 9417093)
has PubMed association: PMID: 8816377; 8886020; 8977299; 9207005; 9211859; 9417093; 9469461; 9480837; 9521068; 9670926; 10469138; 10540332; 10888633; 10910894; 11007922; 11804551; 12163566; 12477932; 12525579; 12547701; 12551893; 12645948; 12832759; 12967681; 14576057; 15053339; 15489334; 15814739; 15992849; 16631222; 17023422; 17082609; 17558413; 17641040; 17693327; 18240029; 18577758; 19074885; 19423540; 20237496; 20406964; 20438785; 20455898; 21976223; 22479563; 22842622; 23043070; 23363815; 23999500
description: chemokine (C-C motif) receptor 8
database cross reference: Ensembl:ENSG00000179934
database cross reference: HGNC:1609
database cross reference: HPRD:03497
database cross reference: MIM:601834
database cross reference: Vega:OTTHUMG00000131290

CNP
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CNP1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CNP
full name from nomenclature authority: 2',3'-cyclic nucleotide 3' phosphodiesterase
NCBI GeneID: 1267
gene map location: 17q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000226 (EC: IEA); GO_0003723 (EC: IEA); GO_0004113 (EC: IEA); GO_0005615 (EC: IDA, PMID: 12379507); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005741 (EC: IEA); GO_0005743 (EC: IEA); GO_0005874 (EC: IDA); GO_0005886 (EC: IEA); GO_0005902 (EC: IEA); GO_0007268 (EC: TAS, PMID: 1322358); GO_0007409 (EC: IEA); GO_0007568 (EC: IEA); GO_0008344 (EC: IEA); GO_0009214 (EC: IEA); GO_0009636 (EC: IEA); GO_0021762 (EC: IEP); GO_0030551 (EC: IEA); GO_0031143 (EC: IEA); GO_0032496 (EC: IEA); GO_0035748 (EC: IEA); GO_0035749 (EC: IEA); GO_0042470 (EC: IEA); GO_0046902 (EC: IEA); GO_0048471 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1315529; 1322358; 1360194; 1385234; 2161933; 2164018; 2835044; 2995854; 6328143; 7821789; 8392017; 8921398; 9268698; 10646504; 11156964; 11842207; 11993850; 12379507; 12452325; 12477932; 12643545; 12947117; 14702039; 15489334; 15502338; 15713463; 16103231; 16343930; 16389193; 16891421; 17010574; 17081065; 17150526; 17215244; 17306456; 17964117; 18289148; 18482256; 18496213; 18676363; 19034380; 19056867; 19165527; 19348671; 19508346; 19913121; 20628086; 21139048; 21525035; 21890473; 21906983; 22053931; 22321011; 22473874; 22505724; 22589395; 22678362; 22954668; 23000965; 23032943; 23084924; 23455922; 23667531; 24250222
description: 2',3'-cyclic nucleotide 3' phosphodiesterase
database cross reference: Ensembl:ENSG00000173786
database cross reference: HGNC:2158
database cross reference: HPRD:00448
database cross reference: MIM:123830
database cross reference: Vega:OTTHUMG00000133502

CR1
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: C3BR
alternative term: C4BR
alternative term: CD35
alternative term: KN
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CR1
full name from nomenclature authority: complement component (3b/4b) receptor 1 (Knops blood group)
NCBI GeneID: 1378
NCBI LocusTag: RP11-57I17.1
gene map location: 1q32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001851 (EC: IDA, PMID: 2972794); GO_0001855 (EC: IDA, PMID: 2972794); GO_0001861 (EC: IDA, PMID: 2972794); GO_0002430 (EC: IDA, PMID: 2972794); GO_0004877 (EC: IDA, PMID: 2972794); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 6910481); GO_0006958 (EC: IEA); GO_0009986 (EC: IDA, PMID: 2972794); GO_0030449 (EC: TAS); GO_0045087 (EC: TAS); GO_0045957 (EC: IDA, PMID: 10531307); GO_0045959 (EC: IDA, PMID: 10531307); GO_0070062 (EC: IDA, PMID: 19056867); GO_1900004 (EC: IDA, PMID: 6910481); GO_1900005 (EC: IDA, PMID: 2972794)
has PubMed association: PMID: 1670949; 1708808; 1708809; 1827486; 2295627; 2411809; 2478758; 2531419; 2551147; 2564414; 2877046; 2933745; 2951479; 2959289; 2971757; 2972794; 2977721; 2989379; 3014040; 3031685; 3155774; 3156931; 3157763; 3305706; 3736743; 3782802; 4019777; 6115248; 6126949; 6222138; 6223944; 6230413; 6572933; 6910481; 6978375; 7690834; 8245463; 8422437; 9089986; 9230440; 9614933; 9988761; 10382758; 10528197; 10528211; 10531307; 10698335; 10737800; 11120776; 11313284; 11694537; 11884446; 11896343; 11955431; 11981823; 12083416; 12091241; 12477932; 12486610; 12490287; 12773320; 12869997; 14556965; 14635039; 14694201; 15069174; 15072851; 15163541; 15176657; 15381817; 15388259; 15526369; 15529364; 15578041; 15660833; 15728520; 15733500; 15864913; 16133175; 16277654; 16289666; 16360013; 16426237; 16433910; 17207243; 17467802; 17709521; 17999656; 18028942; 18075277; 18182380; 18434253; 18684861; 18709693; 18713965; 18842294; 18929826; 18937792; 18954261; 18954403; 19048480; 19056867; 19131551; 19344414; 19480840; 19578791; 19734903; 19874218; 19906204; 19959855; 20237496; 20379614; 20459687; 20534741; 20538029; 20554627; 20558149; 20558387; 20646210; 20670356; 20674675; 20697030; 20702729; 20739100; 20795311; 20855594; 20889874; 20951238; 21251929; 21300948; 21347408; 21358043; 21391232; 21403675; 21459435; 21460840; 21460841; 21593778; 21659422; 21663961; 21700265; 21726919; 21727667; 21784344; 21839519; 21912625; 21985366; 22015308; 22237765; 22244847; 22262751; 22291609; 22333472; 22343410; 22374251; 22402018; 22539578; 22819390; 22888138; 22952074; 22960360; 22962438; 23022416; 23152904; 23202439; 23376460; 23390291; 23416052; 23440418; 23582656; 23591632; 23650005; 24022490; 24214979
description: complement component (3b/4b) receptor 1 (Knops blood group)
database cross reference: Ensembl:ENSG00000203710
database cross reference: HGNC:2334
database cross reference: HPRD:00398
database cross reference: MIM:120620
database cross reference: Vega:OTTHUMG00000036311

CREB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CREB
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CREB1
full name from nomenclature authority: cAMP responsive element binding protein 1
NCBI GeneID: 1385
gene map location: 2q34
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000980 (EC: IDA, PMID: 19861239); GO_0001102 (EC: IPI, PMID: 19861239); GO_0001190 (EC: IDA, PMID: 19861239); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0003700 (EC: IDA, PMID: 8798441); GO_0003705 (EC: IDA, PMID: 19861239); GO_0003712 (EC: TAS, PMID: 8552098); GO_0005515 (EC: IPI, PMID: 10722738); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005667 (EC: IEA); GO_0005719 (EC: IDA, PMID: 19861239); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0006366 (EC: IDA, PMID: 19861239); GO_0006468 (EC: IDA, PMID: 8798441); GO_0007165 (EC: TAS); GO_0007173 (EC: TAS); GO_0007202 (EC: TAS); GO_0007219 (EC: TAS); GO_0007268 (EC: TAS); GO_0007411 (EC: TAS); GO_0007595 (EC: IEA); GO_0008361 (EC: IEA); GO_0008543 (EC: TAS); GO_0010033 (EC: IDA, PMID: 8798441); GO_0010944 (EC: IDA, PMID: 19861239); GO_0016032 (EC: IEA); GO_0021983 (EC: IEA); GO_0033363 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035497 (EC: IDA, PMID: 19861239); GO_0035666 (EC: TAS); GO_0038095 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0040018 (EC: IEA); GO_0042493 (EC: IEA); GO_0045087 (EC: TAS); GO_0045600 (EC: ISS); GO_0045672 (EC: IEA); GO_0045893 (EC: ISS); GO_0045944 (EC: IDA, PMID: 19861239); GO_0046887 (EC: IEA); GO_0046889 (EC: ISS); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0050821 (EC: ISS); GO_0051403 (EC: TAS); GO_0060430 (EC: IEA); GO_0060509 (EC: IEA)
has PubMed association: PMID: 1386673; 1461747; 1655749; 1831258; 1966745; 2138276; 2142119; 2142528; 2974179; 7505393; 7551568; 7554179; 7565761; 7608156; 7619208; 7621901; 7769693; 7809053; 8381074; 8384217; 8449898; 8552098; 8628277; 8663317; 8688081; 8798441; 8887554; 9388250; 9413984; 9558095; 9671480; 9687510; 9770464; 9786917; 9792677; 9829964; 9873047; 10074179; 10506141; 10567391; 10650954; 10720489; 10722738; 10781615; 10848610; 10866654; 10886376; 10909971; 10945975; 11013247; 11018520; 11046156; 11156964; 11160957; 11175347; 11259575; 11313407; 11377386; 11500364; 11564156; 11572863; 11698596; 11909979; 11988318; 12091337; 12145339; 12162494; 12183445; 12196545; 12198160; 12200150; 12220644; 12235136; 12368293; 12391146; 12391222; 12437352; 12477932; 12519783; 12552083; 12567184; 12622660; 12665587; 12676584; 12690113; 12720543; 12743114; 12773552; 12776737; 12805224; 12829027; 12851637; 14506290; 14523007; 14580193; 14597631; 14597636; 14635195; 14646589; 14702039; 14742439; 14754893; 14761884; 14764597; 14962944; 15073328; 15077295; 15082775; 15153340; 15276183; 15340044; 15454081; 15489334; 15500908; 15579595; 15585582; 15588513; 15615708; 15688015; 15691874; 15691881; 15694837; 15703171; 15733869; 15753290; 15806162; 15837624; 15879136; 15897899; 15901830; 15917247; 15961999; 15964553; 15999345; 16007092; 16134057; 16158061; 16169070; 16207717; 16207795; 16223362; 16227528; 16282323; 16293623; 16306050; 16325578; 16330542; 16339753; 16449647; 16483570; 16598418; 16611888; 16675956; 16799563; 16820098; 16822311; 16896160; 16920714; 16963449; 16978443; 16980615; 17082618; 17169345; 17202341; 17276404; 17289023; 17300755; 17310988; 17389598; 17426037; 17449469; 17455223; 17460549; 17476304; 17507637; 17548750; 17565597; 17565598; 17565599; 17565603; 17573727; 17592483; 17646388; 17661722; 17712720; 17724745; 17727817; 17786359; 17805329; 17822787; 17827388; 17889508; 17909078; 17975014; 18022816; 18024382; 18029348; 18034423; 18070920; 18160048; 18189280; 18191017; 18287226; 1…
description: cAMP responsive element binding protein 1
database cross reference: Ensembl:ENSG00000118260
database cross reference: HGNC:2345
database cross reference: HPRD:00442
database cross reference: MIM:123810
database cross reference: Vega:OTTHUMG00000132936

CRMP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CRMP-1
alternative term: DPYSL1
alternative term: DRP-1
alternative term: DRP1
alternative term: ULIP-3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CRMP1
full name from nomenclature authority: collapsin response mediator protein 1
NCBI GeneID: 1400
gene map location: 4p16.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 15383276); GO_0005737 (EC: IDA); GO_0005815 (EC: IEA); GO_0005819 (EC: IEA); GO_0005829 (EC: TAS); GO_0006139 (EC: TAS, PMID: 8973361); GO_0006208 (EC: IEA); GO_0007399 (EC: TAS, PMID: 8973361); GO_0007411 (EC: TAS); GO_0016812 (EC: IEA); GO_0030425 (EC: IEA); GO_0043025 (EC: IEA)
has PubMed association: PMID: 8973361; 10048489; 11562390; 12134159; 12477932; 12482610; 12650609; 14702039; 14996858; 15383276; 15489334; 15492864; 16169070; 16344560; 16611631; 17118363; 18029348; 18524846; 18782567; 19019082; 19362386; 19903856; 20087401; 20379614; 20506281; 21078624; 21139048; 21747164; 21900206; 22359051; 22363707; 22798627; 22863883; 23720494; 24250222
description: collapsin response mediator protein 1
database cross reference: Ensembl:ENSG00000072832
database cross reference: HGNC:2365
database cross reference: HPRD:03913
database cross reference: MIM:602462
database cross reference: Vega:OTTHUMG00000125489

MAPK14
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CSBP
alternative term: CSBP1
alternative term: CSBP2
alternative term: CSPB1
alternative term: EXIP
alternative term: Mxi2
alternative term: PRKM14
alternative term: PRKM15
alternative term: RK
alternative term: SAPK2A
alternative term: p38
alternative term: p38ALPHA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAPK14
full name from nomenclature authority: mitogen-activated protein kinase 14
NCBI GeneID: 1432
NCBI LocusTag: RP1-179N16.5
gene map location: 6p21.3-p21.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000077 (EC: IEA); GO_0000187 (EC: TAS); GO_0000902 (EC: IEA); GO_0000922 (EC: IEA); GO_0001502 (EC: IEA); GO_0001525 (EC: IEA); GO_0002062 (EC: IEA); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004674 (EC: TAS); GO_0004707 (EC: IDA, PMID: 10330143); GO_0004708 (EC: TAS, PMID: 10706854); GO_0005515 (EC: IPI, PMID: 10601328); GO_0005524 (EC: IEA); GO_0005634 (EC: ISS); GO_0005654 (EC: TAS); GO_0005737 (EC: ISS); GO_0005739 (EC: IEA); GO_0005829 (EC: TAS); GO_0006006 (EC: IEA); GO_0006351 (EC: IEA); GO_0006357 (EC: ISS); GO_0006915 (EC: IEA); GO_0006928 (EC: TAS, PMID: 10912793); GO_0006935 (EC: TAS, PMID: 10706854); GO_0007165 (EC: TAS, PMID: 10706854); GO_0007166 (EC: TAS, PMID: 10706854); GO_0007178 (EC: IEA); GO_0007265 (EC: TAS); GO_0007519 (EC: IEA); GO_0007596 (EC: TAS); GO_0010467 (EC: TAS); GO_0010831 (EC: ISS); GO_0016070 (EC: TAS); GO_0016071 (EC: TAS); GO_0018105 (EC: ISS); GO_0019395 (EC: IEA); GO_0030168 (EC: TAS); GO_0030316 (EC: ISS); GO_0031663 (EC: IEA); GO_0032495 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035556 (EC: IDA, PMID: 10838079); GO_0035666 (EC: TAS); GO_0035924 (EC: IMP, PMID: 18440775); GO_0038066 (EC: ISS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042307 (EC: IEA); GO_0042692 (EC: TAS); GO_0042770 (EC: IMP); GO_0043536 (EC: IMP, Qualifier: NOT, PMID: 18440775); GO_0045087 (EC: TAS); GO_0045648 (EC: IEA); GO_0045663 (EC: ISS); GO_0045944 (EC: IEA); GO_0048010 (EC: IMP, PMID: 18440775); GO_0048011 (EC: TAS); GO_0051090 (EC: TAS); GO_0051146 (EC: IEA); GO_0051149 (EC: TAS); GO_0051403 (EC: TAS); GO_0051525 (EC: ISS); GO_0070935 (EC: TAS); GO_0071479 (EC: IMP); GO_0090090 (EC: IEA); GO_0090400 (EC: IMP); GO_1901741 (EC: ISS); GO_2000379 (EC: IMP)
has PubMed association: PMID: 1088347; 7479834; 7535770; 7592979; 7696354; 7716521; 7750576; 7839144; 7914033; 7923354; 7997261; 8083223; 8274451; 8530093; 8548291; 8622669; 8626699; 8650547; 8695800; 8798479; 8846784; 8910361; 8910365; 8917518; 9069290; 9092573; 9095200; 9130707; 9155018; 9162092; 9207092; 9211903; 9235954; 9278512; 9295308; 9297626; 9405468; 9434624; 9465032; 9468497; 9554853; 9628874; 9687510; 9753691; 9753748; 9768359; 9788880; 9792677; 9808624; 9858528; 9878398; 9889198; 10085140; 10206983; 10330143; 10346818; 10348343; 10364159; 10391943; 10415025; 10557092; 10559944; 10581258; 10597297; 10601328; 10644717; 10706854; 10708586; 10727080; 10747897; 10779345; 10805738; 10806207; 10838079; 10849446; 10857861; 10878576; 10884347; 10910078; 10912793; 10942774; 10943842; 10961885; 10978317; 10980603; 11042204; 11042694; 11157753; 11226159; 11259586; 11278395; 11278799; 11279118; 11279232; 11333986; 11344273; 11359773; 11377386; 11387337; 11390380; 11408587; 11416124; 11468147; 11489891; 11495898; 11520933; 11551930; 11551945; 11566021; 11602244; 11604491; 11691836; 11698270; 11741533; 11756422; 11773065; 11777913; 11781324; 11788583; 11788789; 11792706; 11839738; 11847341; 11848686; 11852102; 11866441; 11896401; 11988087; 11994045; 11994493; 11997522; 12009331; 12051955; 12054652; 12067303; 12071847; 12085235; 12089333; 12105188; 12110590; 12126643; 12138194; 12164931; 12170268; 12171600; 12183063; 12200131; 12225289; 12232043; 12239168; 12296996; 12324467; 12370831; 12384504; 12391307; 12403788; 12429732; 12473116; 12477932; 12478662; 12505871; 12509443; 12519482; 12581156; 12589052; 12595530; 12606502; 12631076; 12654092; 12663671; 12665511; 12665801; 12684028; 12697749; 12697810; 12698197; 12702497; 12748288; 12761180; 12775419; 12784337; 12810082; 12819782; 12824191; 12829618; 12855667; 12882963; 12897141; 12933809; 12963847; 13679851; 14499342; 14512875; 14552880; 14563843; 14574404; 14578350; 14586399; 14592977; 14648593; 14660488; 14676314; 14714552; 14715645; 149701…
description: mitogen-activated protein kinase 14
database cross reference: Ensembl:ENSG00000112062
database cross reference: HGNC:6876
database cross reference: HPRD:02619
database cross reference: MIM:600289
database cross reference: Vega:OTTHUMG00000159806

CSE1L
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CAS
alternative term: CSE1
alternative term: XPO2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CSE1L
full name from nomenclature authority: CSE1 chromosome segregation 1-like (yeast)
NCBI GeneID: 1434
gene map location: 20q13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 17719542); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0006611 (EC: TAS, PMID: 9323134); GO_0006915 (EC: TAS, PMID: 7479798); GO_0008262 (EC: TAS, PMID: 9323134); GO_0008283 (EC: TAS, PMID: 7479798); GO_0008536 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 7479798; 8125298; 8639641; 8943292; 8963895; 9323134; 9428644; 9786944; 10331944; 10523667; 11295109; 11310559; 11703094; 11724300; 11780052; 11927559; 12061792; 12477932; 12510150; 12972425; 14718574; 15161933; 15324660; 15489334; 16169070; 16196087; 16786158; 17110338; 17314511; 17719542; 18051367; 18377724; 18425415; 18439902; 18457437; 18781797; 19056867; 19224336; 19471022; 19615732; 19738201; 20016921; 20150437; 20473970; 20734115; 20936779; 21081666; 21139048; 21252943; 21290345; 21319273; 21343306; 21693764; 21890473; 21906983; 21963094; 21983832; 21987572; 22053931; 22110766; 22268729; 22476051; 22586326; 22623428; 22653741; 22678362; 22711543; 22863883; 22939629; 22952058; 22967991; 23000965; 23181366; 23189846; 23455922; 23464991; 23703321; 23806821; 23862649; 23956138; 24250222; 24457600
description: CSE1 chromosome segregation 1-like (yeast)
database cross reference: Ensembl:ENSG00000124207
database cross reference: HGNC:2431
database cross reference: HPRD:03217
database cross reference: MIM:601342
database cross reference: Vega:OTTHUMG00000033046

CSF1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CSF-1
alternative term: MCSF
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CSF1
full name from nomenclature authority: colony stimulating factor 1 (macrophage)
NCBI GeneID: 1435
NCBI LocusTag: RP11-195M16.2
gene map location: 1p13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001503 (EC: IEA); GO_0001954 (EC: ISS, PMID: 18566389); GO_0002158 (EC: IEA); GO_0003006 (EC: ISS, PMID: 19017797); GO_0005125 (EC: IDA, PMID: 10652277); GO_0005157 (EC: ISS, PMID: 19017797); GO_0005157 (EC: TAS, PMID: 2460758); GO_0005615 (EC: IDA, PMID: 2460758); GO_0005886 (EC: IEA); GO_0006954 (EC: IEA); GO_0008083 (EC: IDA, PMID: 2460758); GO_0008083 (EC: NAS, PMID: 1791839); GO_0008283 (EC: NAS, PMID: 1791839); GO_0008284 (EC: IDA, PMID: 10652277); GO_0008284 (EC: TAS, PMID: 2460758); GO_0010628 (EC: IDA, PMID: 10666185); GO_0010743 (EC: NAS, PMID: 18566389); GO_0010744 (EC: IDA, PMID: 17244792); GO_0016020 (EC: NAS, PMID: 2460758); GO_0016021 (EC: IEA); GO_0030097 (EC: NAS, PMID: 1791839); GO_0030154 (EC: NAS, PMID: 1791839); GO_0030225 (EC: TAS, PMID: 2460758); GO_0030278 (EC: IEA); GO_0030316 (EC: IDA, PMID: 18606301); GO_0030335 (EC: ISS, PMID: 18566389); GO_0032270 (EC: IDA, PMID: 1739124); GO_0032946 (EC: IDA, PMID: 2460758); GO_0040018 (EC: IEA); GO_0042117 (EC: NAS, PMID: 18566389); GO_0042476 (EC: IEA); GO_0042488 (EC: IEA); GO_0042803 (EC: IDA, PMID: 3264878); GO_0043235 (EC: ISS, PMID: 19017797); GO_0045087 (EC: IEA); GO_0045651 (EC: IDA, PMID: 2460758); GO_0045657 (EC: ISS, PMID: 18566389); GO_0045672 (EC: IDA, PMID: 15304486); GO_0045860 (EC: ISS, PMID: 18566389); GO_0046579 (EC: IEA); GO_0048471 (EC: IDA, PMID: 1739124); GO_0048873 (EC: IEA); GO_0060444 (EC: IEA); GO_0060611 (EC: IEA); GO_0060763 (EC: IEA)
has PubMed association: PMID: 1334406; 1455231; 1531650; 1540160; 1571567; 1733926; 1739124; 1791839; 2145044; 2408759; 2460758; 2660794; 2996129; 3039346; 3259875; 3264877; 3264878; 3493529; 3498652; 3500041; 7696959; 8086034; 8262907; 8336080; 8355686; 8422357; 8804363; 8981357; 9131001; 9147389; 9632647; 10652277; 10666185; 10857771; 11248655; 11297560; 11369790; 11387343; 11739737; 11792569; 11843897; 12032835; 12372416; 12393446; 12411027; 12456016; 12477932; 12501178; 12548211; 12684699; 12749918; 12790839; 12865350; 12890905; 12894871; 12928417; 12929928; 14605992; 14634568; 14654075; 15001836; 15116247; 15256272; 15261158; 15304486; 15358207; 15489334; 15494511; 15576295; 15624698; 15640942; 15728521; 15780937; 15820145; 15866728; 15919699; 15944252; 16204228; 16267391; 16318581; 16320327; 16344560; 16407111; 16673212; 16844084; 16859503; 16951369; 17108334; 17192722; 17243911; 17244792; 17353186; 17355643; 17368603; 17420255; 17431224; 17443671; 17516513; 17532041; 17589498; 17907802; 17916748; 17918257; 17922812; 17967422; 18219369; 18322228; 18435789; 18467591; 18510570; 18566389; 18606301; 18619508; 18632616; 18668547; 18676750; 18708368; 18718581; 18724005; 18751872; 18852899; 18996518; 19004987; 19008293; 19017797; 19196448; 19432671; 19443701; 19453261; 19561083; 19641137; 19711348; 19913121; 19926892; 19950360; 20237496; 20436471; 20452482; 20455868; 20485444; 20504948; 20628086; 20628624; 20673868; 20839008; 20839921; 20869948; 20925194; 21239715; 21481374; 21623375; 21717212; 21791433; 21854753; 21895511; 21938481; 21945122; 22028782; 22052465; 22082370; 22186992; 22365076; 22678116; 23061794; 23233531; 23251661; 23260168; 23285029; 23471483; 23520016; 23684409; 23688065; 23834954; 23924854; 24157873
description: colony stimulating factor 1 (macrophage)
database cross reference: Ensembl:ENSG00000184371
database cross reference: HGNC:2432
database cross reference: HPRD:00388
database cross reference: MIM:120420
database cross reference: Vega:OTTHUMG00000011646

CSHL1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CS-5
alternative term: CSHP1
alternative term: CSL
alternative term: hCS-L
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CSHL1
full name from nomenclature authority: chorionic somatomammotropin hormone-like 1
NCBI GeneID: 1444
gene map location: 17q24.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005179 (EC: NAS, PMID: 2744760); GO_0005575 (EC: ND); GO_0005576 (EC: IEA); GO_0008150 (EC: ND); GO_0046872 (EC: IEA)
has PubMed association: PMID: 1378436; 1980158; 2744760; 3030680; 8083227; 12370315; 12477932; 19913121; 20628086
description: chorionic somatomammotropin hormone-like 1
database cross reference: Ensembl:ENSG00000204414
database cross reference: HGNC:2442
database cross reference: HPRD:04623
database cross reference: MIM:603515
database cross reference: Vega:OTTHUMG00000172287

CSNK1A1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CK1
alternative term: CK1a
alternative term: CKIa
alternative term: HEL-S-77p
alternative term: HLCDGP1
alternative term: PRO2975
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CSNK1A1
full name from nomenclature authority: casein kinase 1, alpha 1
NCBI GeneID: 1452
gene map location: 5q32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000777 (EC: IEA); GO_0004672 (EC: TAS, PMID: 10777483); GO_0004674 (EC: IDA, PMID: 18305108); GO_0005515 (EC: IPI, PMID: 16511560); GO_0005524 (EC: IEA); GO_0005813 (EC: IDA); GO_0005829 (EC: TAS); GO_0005847 (EC: IDA, Qualifier: colocalizes_with, PMID: 18305108); GO_0006468 (EC: IDA, PMID: 18305108); GO_0007067 (EC: IEA); GO_0007165 (EC: NAS, PMID: 10777483); GO_0007166 (EC: TAS, PMID: 10777483); GO_0016055 (EC: IEA); GO_0016607 (EC: IDA, PMID: 18305108)
has PubMed association: PMID: 1409656; 7559483; 7622570; 7797465; 8050587; 8253806; 8404858; 8972483; 9045708; 9109395; 9360956; 9391750; 9630228; 9765199; 9771888; 10413673; 10617630; 10777483; 10930456; 10961987; 11278595; 11500362; 11583622; 11779193; 11875057; 11884395; 11955436; 12000790; 12062430; 12210746; 12477932; 12820959; 14558941; 14574644; 15003508; 15131121; 15327769; 15489334; 15557340; 15635413; 15687492; 15761153; 16024788; 16061179; 16344560; 16371461; 16511560; 16565220; 16616143; 16753179; 16880514; 16943283; 16959772; 17110929; 17192257; 17318175; 17626781; 17979178; 18067272; 18246126; 18305108; 18411282; 18590726; 18669630; 19050041; 19118383; 19185594; 19244247; 19322201; 19426738; 19531213; 19576224; 19738201; 19759023; 19797085; 19805514; 19875381; 19913121; 20348946; 20360068; 20551178; 20628086; 20647544; 20696773; 21139048; 21179498; 21382349; 21642993; 21890473; 21906983; 21925390; 21963094; 21985131; 21988832; 22017877; 22350414; 22505724; 22623428; 22824801; 22916255; 22939624; 22939629; 23000965; 23028042; 23148689; 23455922; 23580615; 24244405; 24250222
description: casein kinase 1, alpha 1
database cross reference: Ensembl:ENSG00000113712
database cross reference: HGNC:2451
database cross reference: HPRD:02739
database cross reference: MIM:600505
database cross reference: Vega:OTTHUMG00000163463

CST3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ARMD11
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CST3
full name from nomenclature authority: cystatin C
NCBI GeneID: 1471
gene map location: 20p11.21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001540 (EC: IPI, PMID: 18026102); GO_0002020 (EC: IPI, PMID: 6203523); GO_0004866 (EC: IDA, PMID: 15127951); GO_0004869 (EC: IDA, PMID: 6203523); GO_0005515 (EC: IPI, PMID: 15127951); GO_0005576 (EC: IMP, PMID: 18026102); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 18613859); GO_0006952 (EC: IDA, PMID: 6203523); GO_0010466 (EC: IDA, PMID: 6203523); GO_0010703 (EC: IC, PMID: 7890620); GO_0010711 (EC: IEP, PMID: 10545518); GO_0010716 (EC: IEP, PMID: 10545518); GO_0010951 (EC: IDA, PMID: 15127951); GO_0034103 (EC: IEP, PMID: 10545518); GO_0043206 (EC: IGI, PMID: 18026102); GO_0060311 (EC: IMP, PMID: 10545518); GO_0060313 (EC: IEP, PMID: 10545518); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1352269; 1731767; 1996959; 2013314; 2304899; 2363674; 2541223; 2567273; 2689007; 2764935; 2900981; 3495457; 3517880; 6203523; 6283552; 6365094; 6662498; 7890620; 8083219; 8179826; 8486384; 10428479; 10545518; 10993992; 11074789; 11115496; 11276250; 11468325; 11681790; 11711204; 11750287; 11780052; 11815350; 11865157; 12038606; 12101112; 12477932; 12479412; 12483523; 12589965; 12663624; 12670666; 12738401; 12758063; 12787072; 12938144; 14503883; 14672279; 14714581; 14726415; 15013312; 15034766; 15037657; 15086483; 15122877; 15127951; 15174051; 15212828; 15223845; 15336605; 15340161; 15350470; 15479453; 15489334; 15603510; 15719405; 15728313; 15829557; 15832773; 15860739; 15882666; 16005452; 16049933; 16131730; 16170782; 16188386; 16213753; 16386559; 16437581; 16443201; 16446102; 16481598; 16608402; 16612982; 16612983; 16640527; 16713569; 16838182; 16979980; 17130480; 17192785; 17210589; 17310123; 17353786; 17394021; 17470433; 17537416; 17552057; 17636214; 17660266; 17668246; 17718592; 17728092; 17822797; 17826782; 17852800; 17852801; 17901710; 17903292; 17947596; 17963746; 17998865; 18026100; 18026102; 18044340; 18089366; 18187137; 18216060; 18280806; 18307033; 18314113; 18317874; 18319326; 18356552; 18373213; 18376131; 18408364; 18418694; 18454664; 18461289; 18496846; 18508448; 18511756; 18566660; 18594189; 18613859; 18667743; 18674527; 18703370; 18713542; 18804033; 18815241; 18824671; 18830724; 18949742; 18953178; 19056867; 19119287; 19137579; 19151417; 19252175; 19293566; 19357259; 19359536; 19394726; 19403428; 19419268; 19436062; 19446036; 19517296; 19523634; 19585181; 19597297; 19597298; 19601795; 19636441; 19674067; 19741512; 19765773; 19774637; 19808324; 19816197; 19819453; 19861863; 19915865; 19929276; 19938052; 20052346; 20132026; 20157249; 20175878; 20353367; 20383146; 20399428; 20413850; 20447660; 20450259; 20468060; 20482807; 20489688; 20502295; 20534741; 20538834; 20574650; 20576828; 20692472; 20699092; 20802417; 20806899; 20809110; 20849835; 20858…
description: cystatin C
database cross reference: Ensembl:ENSG00000101439
database cross reference: HGNC:2475
database cross reference: HPRD:05056
database cross reference: MIM:604312
database cross reference: Vega:OTTHUMG00000032080

CTH
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CTH
full name from nomenclature authority: cystathionase (cystathionine gamma-lyase)
NCBI GeneID: 1491
gene map location: 1p31.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000096 (EC: TAS); GO_0000098 (EC: TAS); GO_0004123 (EC: IDA, PMID: 10212249); GO_0004123 (EC: TAS); GO_0005515 (EC: IPI); GO_0005516 (EC: IEA); GO_0005634 (EC: IDA); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0006534 (EC: TAS, PMID: 1339280); GO_0016846 (EC: TAS); GO_0018272 (EC: IDA, PMID: 19019829); GO_0019344 (EC: IDA, PMID: 10212249); GO_0019344 (EC: IEA); GO_0019346 (EC: TAS); GO_0030170 (EC: IDA, PMID: 10212249); GO_0030968 (EC: TAS); GO_0034641 (EC: TAS); GO_0043066 (EC: IEA); GO_0043123 (EC: IEA); GO_0044281 (EC: TAS); GO_0044524 (EC: IMP); GO_0044540 (EC: IMP); GO_0047982 (EC: TAS); GO_0051092 (EC: IEA); GO_0051289 (EC: IPI, PMID: 19019829); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070814 (EC: IDA, PMID: 19019829); GO_0080146 (EC: TAS); GO_2001234 (EC: IEA)
has PubMed association: PMID: 1339280; 8125298; 10212249; 12477932; 12574942; 15151507; 15347670; 15489334; 16189514; 16710414; 17311259; 18029348; 18476726; 18676680; 18701025; 18849566; 18988749; 19019829; 19048631; 19056867; 19161160; 19170196; 19261609; 19322201; 19324355; 19418582; 19428278; 19531479; 19625176; 19692168; 19850743; 19913121; 19948975; 20175737; 20446008; 20584029; 20628086; 20634891; 20849728; 21139048; 21507721; 21659522; 21886822; 21890473; 21906983; 21963094; 21988832; 22034194; 22310774; 22360859; 22863883; 23393010; 23410520; 23704251; 24025145
description: cystathionase (cystathionine gamma-lyase)

CTNNB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CTNNB
alternative term: MRD19
alternative term: armadillo
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CTNNB1
full name from nomenclature authority: catenin (cadherin-associated protein), beta 1, 88kDa
NCBI GeneID: 1499
NCBI LocusTag: OK/SW-cl.35
gene map location: 3p21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IBA); GO_0000578 (EC: IBA); GO_0000922 (EC: IEA); GO_0001102 (EC: IPI, PMID: 19443654); GO_0001569 (EC: IBA); GO_0001569 (EC: IC); GO_0001658 (EC: IBA); GO_0001701 (EC: IEA); GO_0001702 (EC: IBA); GO_0001708 (EC: IEA); GO_0001711 (EC: IBA); GO_0001764 (EC: IEA); GO_0001837 (EC: TAS, PMID: 14679171); GO_0001840 (EC: IEA); GO_0001889 (EC: IBA); GO_0002052 (EC: IEA); GO_0002053 (EC: IEA); GO_0002089 (EC: IEA); GO_0003136 (EC: IBA); GO_0003266 (EC: IEA); GO_0003337 (EC: IBA); GO_0003682 (EC: IEA); GO_0003690 (EC: IEA); GO_0003700 (EC: IEA); GO_0003713 (EC: IDA, PMID: 11751639); GO_0003713 (EC: IMP, PMID: 12949260); GO_0004871 (EC: NAS, PMID: 10192393); GO_0005198 (EC: IBA); GO_0005515 (EC: IPI, PMID: 10773885); GO_0005634 (EC: IDA, PMID: 10980594); GO_0005654 (EC: TAS); GO_0005667 (EC: IDA, PMID: 11751639); GO_0005737 (EC: IDA, PMID: 11793365); GO_0005813 (EC: IDA, PMID: 18086858); GO_0005829 (EC: IDA, PMID: 10980594); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA); GO_0005911 (EC: IDA, PMID: 19151727); GO_0005912 (EC: IDA, PMID: 16858403); GO_0005913 (EC: IDA, PMID: 10403777); GO_0005915 (EC: IBA); GO_0005916 (EC: IBA); GO_0005938 (EC: IDA, PMID: 19038973); GO_0006351 (EC: IEA); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0007016 (EC: IBA); GO_0007155 (EC: IMP, PMID: 19101069); GO_0007160 (EC: IBA); GO_0007398 (EC: IBA); GO_0007403 (EC: IBA); GO_0007494 (EC: IEA); GO_0008022 (EC: IPI, PMID: 10773885); GO_0008134 (EC: IPI); GO_0008134 (EC: TAS, PMID: 16344550); GO_0008285 (EC: IDA, PMID: 12970740); GO_0009898 (EC: IBA); GO_0009948 (EC: IEA); GO_0009950 (EC: IBA); GO_0009954 (EC: IBA); GO_0010909 (EC: IMP, PMID: 15853773); GO_0014010 (EC: IBA); GO_0016020 (EC: ISS); GO_0016055 (EC: IDA, PMID: 10644691); GO_0016323 (EC: IEA); GO_0016328 (EC: IDA, PMID: 12072559); GO_0016337 (EC: IMP, PMID: 18593713); GO_0016342 (EC: IDA, PMID: 18593713); GO_0019899 (EC: IPI, PMID: 18356165); GO_0019900 (EC: IPI, PMID: 8638126); GO_0019901 (EC: IBA); GO_0019903 (EC: IPI, PMI…
has PubMed association: PMID: 7542250; 7642713; 7650039; 7702605; 7706414; 7736793; 7806582; 7829088; 7876318; 7890674; 7954478; 8227214; 8259519; 8638126; 8663237; 8757136; 8838805; 9054423; 9065401; 9065402; 9110993; 9139698; 9214391; 9233779; 9245795; 9286858; 9294210; 9312064; 9348292; 9405455; 9419974; 9434630; 9482734; 9500465; 9512503; 9521872; 9535896; 9545347; 9566905; 9601641; 9632714; 9734785; 9738936; 9751710; 9762469; 9819408; 9823329; 9843967; 9852041; 9927029; 9971746; 9990852; 10021369; 10023660; 10026156; 10029089; 10037471; 10074433; 10092585; 10187801; 10192393; 10207020; 10228155; 10321728; 10330181; 10330403; 10341227; 10381631; 10391090; 10398436; 10403777; 10435629; 10462524; 10477752; 10488109; 10491393; 10545404; 10620020; 10635315; 10644691; 10655994; 10666372; 10679188; 10681592; 10706604; 10713156; 10748026; 10753743; 10769211; 10772923; 10773885; 10801826; 10806215; 10816572; 10825188; 10837025; 10861224; 10862698; 10868478; 10873669; 10890911; 10896949; 10898789; 10910767; 10947987; 10951583; 10958684; 10966653; 10980594; 10980707; 10987273; 11035789; 11050151; 11080149; 11080158; 11113628; 11136230; 11136974; 11152665; 11157977; 11166179; 11168528; 11179419; 11226248; 11245482; 11251183; 11254878; 11266540; 11274246; 11279024; 11309300; 11348595; 11389839; 11389840; 11401320; 11483589; 11526121; 11527961; 11532957; 11533658; 11590244; 11703283; 11707392; 11712088; 11713475; 11713476; 11716761; 11734550; 11744694; 11747475; 11751639; 11790773; 11792709; 11793365; 11795941; 11818547; 11819825; 11821434; 11826105; 11831984; 11834740; 11835406; 11836379; 11836555; 11839663; 11856748; 11857309; 11877440; 11889072; 11893906; 11916967; 11920497; 11921277; 11929826; 11930117; 11939410; 11940574; 11950845; 11953860; 11955436; 11955446; 11957146; 11960376; 11967263; 11972058; 11973335; 11983685; 12000714; 12000790; 12003790; 12019147; 12027456; 12037680; 12045208; 12051714; 12052822; 12060769; 12061792; 12070348; 12072559; 12077367; 12095414; 12107263; 12111402; 121140…
description: catenin (cadherin-associated protein), beta 1, 88kDa
database cross reference: Ensembl:ENSG00000168036
database cross reference: HGNC:2514
database cross reference: HPRD:00286
database cross reference: MIM:116806
database cross reference: Vega:OTTHUMG00000131393

CTSS
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CTSS
full name from nomenclature authority: cathepsin S
NCBI GeneID: 1520
gene map location: 1q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001968 (EC: IPI); GO_0002224 (EC: TAS); GO_0002250 (EC: IEP, PMID: 15196205); GO_0002474 (EC: TAS); GO_0002480 (EC: TAS); GO_0004197 (EC: IDA); GO_0005518 (EC: IDA); GO_0005576 (EC: NAS, PMID: 14718574); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA); GO_0005764 (EC: IDA, PMID: 15196205); GO_0006508 (EC: TAS, PMID: 1373132); GO_0006955 (EC: TAS, PMID: 8157683); GO_0019882 (EC: TAS, PMID: 15196205); GO_0019886 (EC: TAS); GO_0022617 (EC: TAS); GO_0030198 (EC: TAS); GO_0030574 (EC: IDA); GO_0034769 (EC: IDA); GO_0036021 (EC: TAS); GO_0042590 (EC: TAS); GO_0043202 (EC: TAS); GO_0043231 (EC: IDA); GO_0043236 (EC: IDA); GO_0043394 (EC: IPI); GO_0045087 (EC: TAS); GO_0051603 (EC: IDA); GO_0097067 (EC: IEP)
has PubMed association: PMID: 1373132; 1377692; 2044774; 7575468; 7717452; 7890620; 8083219; 8157683; 8706894; 9076588; 9099979; 9143502; 9164868; 9524075; 9545324; 9548757; 9876921; 10395917; 10721671; 10852705; 11115496; 11134363; 11241311; 11435427; 11710834; 11856830; 11884425; 12164923; 12437117; 12477932; 12643447; 12742663; 12748383; 12819022; 14718574; 14966190; 15196205; 15489334; 16140306; 16338279; 16354158; 16394095; 16410454; 16550604; 16710414; 16825321; 16839849; 17075137; 17227755; 17601350; 17622942; 17878156; 18029348; 18410260; 18565099; 18957408; 18977241; 19101991; 19104823; 19336475; 19404922; 19487544; 19553543; 19593952; 19700239; 19849712; 19913121; 19939935; 20045715; 20164293; 20180636; 20356901; 20628086; 20880494; 20881085; 21038029; 21094118; 21112096; 21143385; 21223957; 21250859; 21315176; 21585286; 21756348; 21878432; 21896479; 21967108; 21989182; 22101325; 22365146; 22424724; 22571763; 22730330; 22761382; 22796222; 22844403; 22844527; 22923671; 22952693; 23362198; 23585552; 23707200; 23742758; 23747398; 24335416
description: cathepsin S

CYP19A1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ARO
alternative term: ARO1
alternative term: CPV1
alternative term: CYAR
alternative term: CYP19
alternative term: CYPXIX
alternative term: P-450AROM
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CYP19A1
full name from nomenclature authority: cytochrome P450, family 19, subfamily A, polypeptide 1
NCBI GeneID: 1588
gene map location: 15q21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005506 (EC: IEA); GO_0005783 (EC: IDA); GO_0005789 (EC: TAS); GO_0006694 (EC: TAS, PMID: 2848247); GO_0006703 (EC: TAS); GO_0006805 (EC: TAS); GO_0008202 (EC: TAS); GO_0008209 (EC: IEA); GO_0009055 (EC: TAS, PMID: 2848247); GO_0016020 (EC: TAS, PMID: 2848247); GO_0016125 (EC: TAS); GO_0016712 (EC: TAS, PMID: 1371509); GO_0019825 (EC: TAS, PMID: 2848247); GO_0020037 (EC: IDA, PMID: 19129847); GO_0044281 (EC: TAS); GO_0060736 (EC: IEA); GO_0070330 (EC: IDA, PMID: 19129847)
has PubMed association: PMID: 1371509; 1472013; 1724289; 1825497; 2040633; 2171939; 2541021; 2691883; 2808431; 2848247; 2973313; 3018730; 3390233; 3653507; 3964273; 7690033; 8090165; 8117272; 8265607; 8477708; 8530621; 9177373; 9211678; 9696881; 10566648; 10837748; 11076863; 11140838; 11181459; 11216915; 11232039; 11256614; 11344237; 11469726; 11571725; 11595700; 11756225; 11826265; 11850203; 11850205; 11850206; 11850208; 11850209; 11850210; 11850219; 11850220; 11850221; 11850222; 11850224; 11850225; 11850230; 11850233; 11850235; 11897504; 11903314; 11904449; 11925378; 11927588; 11935306; 11997208; 12036913; 12053085; 12154211; 12160997; 12161013; 12161505; 12164325; 12204674; 12213901; 12351690; 12370109; 12385014; 12428207; 12451990; 12462076; 12462077; 12466340; 12477932; 12489562; 12517592; 12592380; 12602902; 12606587; 12618873; 12620480; 12639945; 12690088; 12705475; 12720534; 12734209; 12736278; 12759877; 12768436; 12788892; 12839940; 12843146; 12846271; 12864794; 12914527; 12917334; 12944421; 14508827; 14517714; 14580722; 14593077; 14602139; 14631363; 14634838; 14714492; 14715870; 14744739; 14747179; 14973387; 14981949; 14990865; 15046111; 15072827; 15072828; 15074077; 15079018; 15083376; 15083377; 15083380; 15083381; 15126575; 15128046; 15132727; 15177662; 15181061; 15183689; 15199113; 15207764; 15229337; 15241822; 15298966; 15319333; 15330195; 15358790; 15364411; 15449726; 15489336; 15582747; 15583024; 15613678; 15640252; 15668497; 15677755; 15688015; 15695318; 15748828; 15774541; 15788666; 15794932; 15800924; 15802318; 15840311; 15862960; 15862961; 15862962; 15955695; 16019206; 16020944; 16024248; 16039845; 16045239; 16086586; 16103457; 16128984; 16146740; 16199862; 16202920; 16213843; 16232327; 16244490; 16251630; 16251760; 16260521; 16269961; 16287071; 16302261; 16303757; 16306085; 16322405; 16344016; 16344560; 16381901; 16392624; 16395678; 16402077; 16406421; 16418790; 16424004; 16426763; 16467490; 16473000; 16498360; 16498361; 16498363; 16498364; 16541304; 16556483; 16566930…
description: cytochrome P450, family 19, subfamily A, polypeptide 1
database cross reference: Ensembl:ENSG00000137869
database cross reference: HGNC:2594
database cross reference: HPRD:00488
database cross reference: MIM:107910
database cross reference: Vega:OTTHUMG00000131747

DAB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: DAB1
full name from nomenclature authority: Dab, reelin signal transducer, homolog 1 (Drosophila)
NCBI GeneID: 1600
NCBI LocusTag: RP6-239D12.2
gene map location: 1p32-p31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005829 (EC: IEA); GO_0005903 (EC: IEA); GO_0007162 (EC: IEA); GO_0007264 (EC: IEA); GO_0007494 (EC: IEA); GO_0007628 (EC: IEA); GO_0014069 (EC: IEA); GO_0016020 (EC: IEA); GO_0016358 (EC: IEA); GO_0021517 (EC: IEA); GO_0021589 (EC: IEA); GO_0021813 (EC: IEA); GO_0021942 (EC: IEA); GO_0042493 (EC: IEA); GO_0043005 (EC: IEA); GO_0043025 (EC: IEA); GO_0043548 (EC: IEA); GO_0045177 (EC: IEA); GO_0045666 (EC: IEA); GO_0045860 (EC: IEA); GO_0046426 (EC: IEA); GO_0048471 (EC: IEA); GO_0048712 (EC: IEA); GO_0050771 (EC: IEA); GO_0051645 (EC: IEA); GO_0097477 (EC: IEA)
has PubMed association: PMID: 9716537; 9790777; 9837937; 10373567; 10380922; 10460257; 10827173; 10959835; 11137154; 11279201; 11716507; 11812785; 11967127; 12077184; 12446734; 12477932; 12508107; 12581169; 12606711; 12646221; 12834112; 14578885; 14702039; 14961563; 15062102; 15175076; 15718228; 15883038; 16273093; 16481437; 16951405; 17062576; 17548821; 17974915; 18008369; 18076569; 18089558; 18519826; 19116273; 19853035; 19913121; 20041166; 20379614; 20568118; 20600896; 20628086; 21221998; 21315259; 21453247; 21832049; 22163036; 22394407; 22419519; 22610502; 22815893; 23333377; 23449627; 23568457
description: Dab, reelin signal transducer, homolog 1 (Drosophila)

DAPK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DAPK
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: DAPK1
full name from nomenclature authority: death-associated protein kinase 1
NCBI GeneID: 1612
gene map location: 9q21.33
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004672 (EC: IDA, PMID: 7828849); GO_0004674 (EC: TAS, PMID: 16756490); GO_0004683 (EC: IDA, PMID: 10629061); GO_0005515 (EC: IPI, PMID: 15616583); GO_0005516 (EC: IDA, PMID: 10629061); GO_0005524 (EC: IDA, PMID: 10629061); GO_0005737 (EC: IEA); GO_0006468 (EC: IDA, PMID: 10629061); GO_0006468 (EC: TAS, PMID: 16756490); GO_0006915 (EC: IGI, PMID: 7828849); GO_0006915 (EC: IMP, PMID: 10629061); GO_0006915 (EC: TAS); GO_0008625 (EC: IEA); GO_0010506 (EC: TAS, PMID: 16756490); GO_0015629 (EC: IDA, PMID: 10629061); GO_0017148 (EC: IDA, PMID: 18995835); GO_0035556 (EC: IDA, PMID: 10629061); GO_0042802 (EC: IPI, PMID: 19180116); GO_0042981 (EC: IBA); GO_0042981 (EC: TAS, PMID: 16756490); GO_0043065 (EC: TAS); GO_0043066 (EC: IEA); GO_0046777 (EC: IDA, PMID: 10629061); GO_0046777 (EC: TAS, PMID: 16756490); GO_0071346 (EC: IDA, PMID: 18995835); GO_0097190 (EC: IMP, PMID: 7828849); GO_1902042 (EC: IEA); GO_2000310 (EC: ISS)
has PubMed association: PMID: 7828849; 8530096; 8889549; 10629061; 11485996; 11579085; 11809677; 12031912; 12082610; 12351649; 12370243; 12477932; 12708480; 12730201; 12792765; 12820391; 12911633; 14504087; 14530257; 14612952; 14767518; 15001356; 15018706; 15048887; 15146197; 15342556; 15492995; 15616583; 15634757; 15729359; 15809761; 16085644; 16132846; 16142356; 16213824; 16344560; 16756490; 16847012; 16858683; 16951219; 17056602; 17209433; 17244621; 17319784; 17324927; 17324930; 17339337; 17477876; 17523078; 17540169; 17592394; 17683884; 17690039; 17703233; 17868341; 17895359; 17953697; 18026971; 18195017; 18292548; 18336955; 18349282; 18422656; 18425396; 18519826; 18583991; 18799028; 18813964; 18830724; 18974095; 18995835; 19018866; 19094228; 19148529; 19180116; 19196380; 19212339; 19237746; 19259700; 19267229; 19272801; 19395874; 19506903; 19521987; 19627511; 19628771; 19695681; 19712061; 19778817; 19795445; 19878310; 19917631; 19957692; 20005690; 20018188; 20098747; 20103772; 20220139; 20360646; 20379614; 20389280; 20413850; 20471512; 20514412; 20534741; 20574532; 20630662; 20655775; 20677014; 20682398; 20704749; 20811724; 21115918; 21134130; 21139048; 21152427; 21152877; 21159370; 21167819; 21172653; 21176336; 21212658; 21287504; 21302620; 21311567; 21353277; 21497122; 21516484; 21725354; 21749573; 21797120; 21918973; 21922274; 21965790; 21979297; 22087225; 22095288; 22096027; 22116316; 22136354; 22160140; 22230750; 22293537; 22371043; 22420243; 22465880; 22490852; 22490855; 22549447; 22552543; 22610502; 22785394; 22827846; 22988864; 23175185; 23245584; 23275143; 23383130; 23438478; 23478405; 23545262; 23702034; 23800064; 23806751; 24314662
description: death-associated protein kinase 1
database cross reference: Ensembl:ENSG00000196730
database cross reference: HGNC:2674
database cross reference: HPRD:02902
database cross reference: MIM:600831
database cross reference: Vega:OTTHUMG00000020150

ACE
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ACE1
alternative term: CD143
alternative term: DCP
alternative term: DCP1
alternative term: ICH
alternative term: MVCD3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ACE
full name from nomenclature authority: angiotensin I converting enzyme
NCBI GeneID: 1636
gene map location: 17q23.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001822 (EC: IMP, PMID: 16116425); GO_0001974 (EC: IC, PMID: 1668266); GO_0002003 (EC: TAS); GO_0002005 (EC: IC, PMID: 1668266); GO_0002019 (EC: IC, PMID: 1668266); GO_0003081 (EC: IC, PMID: 1668266); GO_0003779 (EC: IDA, PMID: 16186248); GO_0004175 (EC: IDA, PMID: 15283675); GO_0004180 (EC: IEA); GO_0005515 (EC: IPI, PMID: 16186248); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 15283675); GO_0005768 (EC: IDA, PMID: 17077303); GO_0005886 (EC: IDA, PMID: 16186248); GO_0005886 (EC: TAS); GO_0008144 (EC: IDA, PMID: 1320019); GO_0008217 (EC: ISS); GO_0008237 (EC: IDA, PMID: 1320019); GO_0008237 (EC: ISS); GO_0008241 (EC: IDA, PMID: 1320019); GO_0008241 (EC: ISS, PMID: 11303049); GO_0008270 (EC: IDA, PMID: 12540854); GO_0009897 (EC: IDA, PMID: 9449382); GO_0014910 (EC: ISS); GO_0016021 (EC: IEA); GO_0019229 (EC: IC, PMID: 1668266); GO_0031404 (EC: IDA, PMID: 12540854); GO_0031711 (EC: IPI, PMID: 17077303); GO_0032943 (EC: IC, PMID: 7876104); GO_0042312 (EC: IC, PMID: 4322742); GO_0042447 (EC: IDA, PMID: 7876104); GO_0042447 (EC: ISS, PMID: 11303049); GO_0043171 (EC: IDA, PMID: 4322742); GO_0044267 (EC: TAS); GO_0050482 (EC: IDA, PMID: 17077303); GO_0060218 (EC: IC, PMID: 7876104); GO_0070062 (EC: IDA, PMID: 15326289)
has PubMed association: PMID: 1316930; 1320019; 1328889; 1338766; 1649623; 1668266; 2547653; 2554286; 2558109; 2849100; 4322742; 7876104; 7977726; 8131300; 8253769; 8541160; 8577943; 8755737; 9013598; 9449382; 9699903; 9916793; 10319862; 10391210; 10748135; 10769174; 10924499; 10969042; 11024215; 11027844; 11029323; 11030378; 11035682; 11036822; 11053482; 11054622; 11071585; 11076943; 11078932; 11079515; 11079661; 11082147; 11084577; 11085286; 11106322; 11106834; 11116112; 11116113; 11121171; 11122103; 11122322; 11124487; 11136175; 11137090; 11142763; 11155292; 11155741; 11168787; 11181802; 11200871; 11204304; 11208361; 11208365; 11208681; 11208755; 11210078; 11213892; 11217909; 11230288; 11231997; 11234416; 11239522; 11244007; 11248758; 11250978; 11256792; 11257269; 11265121; 11273991; 11280044; 11283791; 11286523; 11288810; 11289708; 11300226; 11303049; 11305733; 11311153; 11313676; 11317203; 11328206; 11330506; 11330874; 11341749; 11344227; 11345362; 11352521; 11354635; 11354780; 11354781; 11355019; 11357377; 11359065; 11361058; 11377823; 11381371; 11387483; 11399938; 11401071; 11401115; 11402126; 11408790; 11409168; 11421129; 11422735; 11427204; 11428725; 11431175; 11436125; 11436566; 11437027; 11446493; 11447495; 11459796; 11463587; 11473656; 11474225; 11484170; 11485372; 11485566; 11487079; 11498459; 11501342; 11505631; 11507973; 11509536; 11518842; 11522714; 11522715; 11525534; 11527624; 11531970; 11532108; 11544438; 11545752; 11568114; 11568784; 11569699; 11577832; 11593098; 11596779; 11599244; 11640993; 11665795; 11668351; 11677359; 11688760; 11691520; 11692002; 11696022; 11696658; 11696688; 11699055; 11707217; 11707686; 11711521; 11711524; 11712321; 11713104; 11714857; 11715070; 11718065; 11720769; 11723093; 11728946; 11732226; 11733623; 11737220; 11747437; 11749850; 11756350; 11768721; 11770799; 11773214; 11774217; 11775123; 11776100; 11776522; 11781693; 11787479; 11791024; 11791802; 11793101; 11796676; 11802972; 11803189; 11818755; 11821698; 11835945; 11836444; 11840772; 118420…
description: angiotensin I converting enzyme
database cross reference: Ensembl:ENSG00000159640
database cross reference: HGNC:2707
database cross reference: HPRD:00108
database cross reference: MIM:106180
database cross reference: Vega:OTTHUMG00000154927

DLG4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PSD95
alternative term: SAP-90
alternative term: SAP90
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: DLG4
full name from nomenclature authority: discs, large homolog 4 (Drosophila)
NCBI GeneID: 1742
gene map location: 17p13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002091 (EC: ISS); GO_0005515 (EC: IPI, PMID: 10433268); GO_0005737 (EC: ISS); GO_0005783 (EC: ISS); GO_0005886 (EC: ISS, Qualifier: colocalizes_with); GO_0005886 (EC: TAS); GO_0006461 (EC: IDA, PMID: 15496675); GO_0007165 (EC: TAS, PMID: 10364559); GO_0007204 (EC: ISS); GO_0007268 (EC: TAS); GO_0007399 (EC: TAS, PMID: 9286702); GO_0007411 (EC: TAS); GO_0007612 (EC: TAS, PMID: 9853749); GO_0008021 (EC: ISS); GO_0008022 (EC: IPI, PMID: 7477295); GO_0008328 (EC: ISS, Qualifier: colocalizes_with); GO_0014069 (EC: ISS); GO_0016188 (EC: ISS); GO_0019903 (EC: ISS); GO_0030054 (EC: ISS); GO_0030165 (EC: ISS); GO_0030666 (EC: TAS); GO_0030863 (EC: IDA, PMID: 12151521); GO_0031234 (EC: ISS); GO_0031697 (EC: ISS); GO_0031748 (EC: ISS); GO_0031812 (EC: ISS); GO_0032281 (EC: ISS); GO_0032403 (EC: ISS); GO_0032839 (EC: ISS); GO_0033130 (EC: ISS); GO_0035176 (EC: IEA); GO_0035255 (EC: ISS); GO_0035418 (EC: IDA, PMID: 15496675); GO_0035641 (EC: IEA); GO_0044224 (EC: ISS); GO_0044306 (EC: ISS); GO_0044309 (EC: ISS); GO_0045184 (EC: IDA, PMID: 15496675); GO_0045202 (EC: IDA, PMID: 15496675); GO_0045211 (EC: IDA, PMID: 12151521); GO_0048169 (EC: ISS); GO_0050806 (EC: ISS); GO_0050885 (EC: IEA); GO_0060076 (EC: ISS); GO_0060997 (EC: ISS); GO_0071625 (EC: IEA); GO_0097110 (EC: ISS); GO_0097113 (EC: ISS); GO_0097113 (EC: TAS, PMID: 19914352); GO_0097120 (EC: ISS); GO_0097481 (EC: ISS); GO_2000310 (EC: ISS); GO_2000463 (EC: ISS); GO_2000821 (EC: IEA)
has PubMed association: PMID: 7477295; 7569905; 8601796; 8615909; 8625413; 8665664; 8755482; 8938729; 9009191; 9024696; 9115257; 9148889; 9182804; 9278515; 9286702; 9286858; 9326658; 9430700; 9459447; 9481670; 9482110; 9502803; 9581761; 9581762; 9756850; 9786987; 9808460; 9853749; 9870942; 9892651; 10026200; 10207009; 10336672; 10341223; 10364559; 10373510; 10433268; 10488080; 10521598; 10527873; 10595517; 10627592; 10648730; 10725395; 10827173; 10839362; 10844022; 10859302; 10939335; 10958799; 10995758; 11029657; 11060025; 11134026; 11140673; 11152698; 11222640; 11274188; 11276111; 11279080; 11279111; 11319238; 11368788; 11440998; 11483650; 11502259; 11506858; 11526121; 11572861; 11679592; 11714708; 11723117; 11744724; 11805122; 11925566; 11937501; 11997254; 12006486; 12067714; 12068077; 12097473; 12151521; 12359873; 12390249; 12419528; 12435606; 12477932; 12531901; 12576483; 12586822; 12597860; 12609736; 12675619; 12682061; 12713445; 12738960; 12815021; 12860415; 12950712; 14622581; 14732708; 14760703; 14960569; 15024025; 15030493; 15317815; 15458844; 15494726; 15496675; 15603740; 15673434; 15978582; 16316992; 16332682; 16466689; 16473877; 16530958; 16637659; 16767099; 16828986; 16964398; 16990550; 16990791; 16990796; 17018285; 17093888; 17164261; 17360663; 17474147; 17474715; 17506933; 17672918; 17854350; 17916412; 18067320; 18308477; 18311135; 18424056; 18570704; 19017653; 19036954; 19118189; 19274064; 19322201; 19483657; 19726651; 19774677; 19913121; 19914352; 20201926; 20628086; 20921115; 21145461; 21151988; 21670103; 21726550; 21756874; 21849550; 21965656; 22001757; 22479202; 22673509; 22709448; 22745667; 22807451; 22809504; 22843680; 23260144; 23691031; 23782696; 23936182
description: discs, large homolog 4 (Drosophila)
database cross reference: Ensembl:ENSG00000132535
database cross reference: HGNC:2903
database cross reference: HPRD:04199
database cross reference: MIM:602887
database cross reference: Vega:OTTHUMG00000134327

DMRT1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CT154
alternative term: DMT1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: DMRT1
full name from nomenclature authority: doublesex and mab-3 related transcription factor 1
NCBI GeneID: 1761
gene map location: 9p24.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: ISS); GO_0000902 (EC: IEA); GO_0000987 (EC: ISS); GO_0002176 (EC: ISS); GO_0003700 (EC: IEA); GO_0005634 (EC: ISS); GO_0005737 (EC: IEA); GO_0006351 (EC: IEA); GO_0007283 (EC: IEA); GO_0007530 (EC: TAS, PMID: 10332030); GO_0008354 (EC: IEA); GO_0008584 (EC: TAS, PMID: 10332030); GO_0030238 (EC: ISS); GO_0035556 (EC: IEA); GO_0042803 (EC: IEA); GO_0045835 (EC: ISS); GO_0045840 (EC: ISS); GO_0045944 (EC: ISS); GO_0046661 (EC: ISS); GO_0046872 (EC: IEA); GO_0046982 (EC: IEA); GO_0048599 (EC: IEA); GO_0060008 (EC: ISS); GO_0060009 (EC: IEA); GO_0060903 (EC: IEA); GO_2000020 (EC: IEA)
has PubMed association: PMID: 9490411; 10332030; 10604464; 10857744; 10999792; 11040213; 11252745; 11329013; 12434333; 12477932; 15164053; 15489334; 16617334; 20007774; 20211142; 20379614; 20467438; 20543847; 20596660; 20685758; 21462105; 21551455; 21617256; 22573722; 22899867; 22939835; 23251661; 23303528; 23377640; 23555275; 23666239; 23666240
description: doublesex and mab-3 related transcription factor 1
database cross reference: Ensembl:ENSG00000137090
database cross reference: HGNC:2934
database cross reference: HPRD:03885
database cross reference: MIM:602424
database cross reference: Vega:OTTHUMG00000019435

DPYSL2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CRMP-2
alternative term: CRMP2
alternative term: DHPRP2
alternative term: DRP-2
alternative term: DRP2
alternative term: N2A3
alternative term: ULIP-2
alternative term: ULIP2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: DPYSL2
full name from nomenclature authority: dihydropyrimidinase-like 2
NCBI GeneID: 1808
gene map location: 8p22-p21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001975 (EC: IEA); GO_0004157 (EC: TAS, PMID: 8973361); GO_0005515 (EC: IPI, PMID: 16260607); GO_0005739 (EC: IEA); GO_0005829 (EC: IDA); GO_0005829 (EC: TAS); GO_0005874 (EC: IDA, Qualifier: colocalizes_with); GO_0006139 (EC: TAS, PMID: 8973361); GO_0006208 (EC: IEA); GO_0006897 (EC: IMP); GO_0007010 (EC: ISS); GO_0007165 (EC: TAS, PMID: 8973361); GO_0007399 (EC: TAS, PMID: 8973361); GO_0007411 (EC: TAS); GO_0014049 (EC: IEA); GO_0016020 (EC: IDA, Qualifier: colocalizes_with); GO_0019901 (EC: IEA); GO_0021510 (EC: IEA); GO_0021772 (EC: IEA); GO_0030424 (EC: IEA); GO_0030425 (EC: IEA); GO_0030426 (EC: IEA); GO_0042220 (EC: IEA); GO_0042493 (EC: IEA); GO_0043025 (EC: IEA); GO_0045664 (EC: IEA); GO_0048489 (EC: IEA); GO_0070062 (EC: IDA)
has PubMed association: PMID: 7637782; 8125298; 8640231; 8973361; 10574455; 10757975; 10770920; 10818093; 10956643; 11121447; 11741937; 11771764; 12134159; 12477932; 12482610; 12942088; 12951196; 14702039; 15207709; 15342556; 15489334; 15652488; 15672539; 15858820; 16260607; 16321170; 16344560; 16380905; 16611631; 16964243; 17043677; 17229153; 17500595; 17683481; 18029348; 18203259; 18218617; 18460467; 18583979; 19110265; 19151921; 19235893; 19322201; 19328558; 19405953; 19519308; 19659462; 19666111; 20379614; 20381070; 20414250; 20801876; 21139048; 21271304; 21302347; 21319273; 21521879; 21565611; 21642979; 21694731; 21832084; 21860090; 21890473; 21900206; 21988832; 22227566; 22279220; 22431514; 22443207; 22586326; 22863883; 22954668; 23000965; 23023514; 23185275; 23836888; 24036111; 24133216; 24250222
description: dihydropyrimidinase-like 2
database cross reference: Ensembl:ENSG00000092964
database cross reference: HGNC:3014
database cross reference: HPRD:03914
database cross reference: MIM:602463
database cross reference: Vega:OTTHUMG00000099439

DPYSL3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CRMP-4
alternative term: CRMP4
alternative term: DRP-3
alternative term: DRP3
alternative term: LCRMP
alternative term: ULIP
alternative term: ULIP-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: DPYSL3
full name from nomenclature authority: dihydropyrimidinase-like 3
NCBI GeneID: 1809
gene map location: 5q32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005615 (EC: ISS); GO_0005829 (EC: ISS); GO_0005829 (EC: TAS); GO_0006208 (EC: IEA); GO_0007411 (EC: TAS); GO_0010976 (EC: ISS); GO_0010977 (EC: ISS); GO_0016812 (EC: IEA); GO_0017124 (EC: ISS); GO_0030027 (EC: ISS); GO_0030336 (EC: ISS); GO_0030426 (EC: ISS); GO_0031941 (EC: ISS); GO_0035374 (EC: ISS); GO_0044297 (EC: ISS); GO_0048678 (EC: ISS); GO_0051017 (EC: ISS); GO_0051219 (EC: IEA); GO_0051260 (EC: ISS); GO_0051491 (EC: ISS); GO_0051764 (EC: ISS); GO_0070382 (EC: ISS, Qualifier: colocalizes_with); GO_0071345 (EC: ISS)
has PubMed association: PMID: 1602151; 8973361; 9115293; 10664068; 10748015; 10956643; 11771764; 12134159; 12444086; 12477932; 12745088; 15345747; 15933812; 16611631; 17043677; 17081983; 18029348; 20379614; 20543870; 20804502; 20977846; 21044950; 21139048; 21179545; 21319273; 22863883; 23000965; 23568759; 24011394
description: dihydropyrimidinase-like 3
database cross reference: Ensembl:ENSG00000113657
database cross reference: HGNC:3015
database cross reference: HPRD:03104
database cross reference: MIM:601168
database cross reference: Vega:OTTHUMG00000163437

DVL1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DVL
alternative term: DVL1L1
alternative term: DVL1P1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: DVL1
full name from nomenclature authority: dishevelled segment polarity protein 1
NCBI GeneID: 1855
NCBI LocusTag: RP5-890O3.5
gene map location: 1p36
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001505 (EC: ISS); GO_0003674 (EC: ND); GO_0004871 (EC: IEA); GO_0005109 (EC: IPI, PMID: 19388021); GO_0005515 (EC: IPI, PMID: 10330181); GO_0005737 (EC: IEA); GO_0005829 (EC: IEA); GO_0005874 (EC: IBA); GO_0005938 (EC: IBA); GO_0006366 (EC: IDA, PMID: 11742073); GO_0006469 (EC: IDA, PMID: 10330181); GO_0007269 (EC: ISS); GO_0007411 (EC: IBA); GO_0007507 (EC: NAS, PMID: 8644734); GO_0007528 (EC: ISS); GO_0010976 (EC: IEA); GO_0016023 (EC: ISS); GO_0016055 (EC: IEA); GO_0016328 (EC: IDA, Qualifier: colocalizes_with); GO_0019899 (EC: IPI, PMID: 15454084); GO_0019901 (EC: IPI, PMID: 19643732); GO_0021915 (EC: IEP, PMID: 8817329); GO_0022007 (EC: IEA); GO_0030136 (EC: IBA); GO_0030177 (EC: IDA, PMID: 11113207); GO_0030424 (EC: IBA); GO_0030425 (EC: IBA); GO_0030426 (EC: IBA); GO_0031122 (EC: IEA); GO_0031410 (EC: IDA, PMID: 11113207); GO_0032091 (EC: IDA, PMID: 19643732); GO_0032436 (EC: IMP); GO_0034504 (EC: IMP, PMID: 10330181); GO_0035176 (EC: IEA); GO_0035372 (EC: IEA); GO_0035556 (EC: IEA); GO_0042802 (EC: IPI, PMID: 10330181); GO_0043025 (EC: IBA); GO_0043113 (EC: ISS); GO_0045202 (EC: IBA); GO_0045202 (EC: ISS); GO_0045893 (EC: IDA, PMID: 12805222); GO_0048365 (EC: IBA); GO_0048668 (EC: IBA); GO_0048675 (EC: IBA); GO_0048813 (EC: IBA); GO_0048813 (EC: ISS); GO_0050808 (EC: ISS); GO_0060026 (EC: IBA); GO_0060070 (EC: IDA, PMID: 11113207); GO_0060071 (EC: IDA, PMID: 12805222); GO_0060134 (EC: IEA); GO_0071340 (EC: IBA); GO_0090103 (EC: IBA); GO_0090179 (EC: IBA); GO_0090263 (EC: IEA)
has PubMed association: PMID: 8288125; 8644734; 8817329; 8856345; 9192851; 9344861; 9482734; 10330181; 10330403; 10332026; 10428961; 10581192; 10644691; 10806215; 11113207; 11487578; 11742073; 11779461; 11803455; 11818547; 12477932; 12490194; 12533515; 12556519; 12650946; 12805222; 12824876; 12883684; 12941796; 14684739; 14702039; 14747478; 14750955; 15262978; 15342556; 15454084; 15456783; 15852005; 16169070; 16457155; 16621789; 17593335; 18093802; 18162551; 18223681; 18347071; 18632848; 18692936; 18760999; 18976975; 19388021; 19453261; 19465938; 19561074; 19625296; 19643732; 19956716; 20177058; 20227366; 20388731; 20412773; 20439735; 20634891; 20639201; 20846493; 21044957; 21262972; 21900206; 21906983; 21963094; 21988832; 22467858; 22826439; 23836490
description: dishevelled segment polarity protein 1
database cross reference: Ensembl:ENSG00000107404
database cross reference: HGNC:3084
database cross reference: HPRD:03220
database cross reference: MIM:601365
database cross reference: Vega:OTTHUMG00000003069

DYRK1A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DYRK
alternative term: DYRK1
alternative term: HP86
alternative term: MNB
alternative term: MNBH
alternative term: MRD7
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: DYRK1A
full name from nomenclature authority: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
NCBI GeneID: 1859
gene map location: 21q22.13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 21
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000278 (EC: TAS); GO_0004672 (EC: TAS, PMID: 8769099); GO_0004674 (EC: ISS); GO_0004712 (EC: IEA); GO_0004713 (EC: ISS); GO_0004715 (EC: IDA, PMID: 9748265); GO_0005515 (EC: IPI, PMID: 14500717); GO_0005524 (EC: IEA); GO_0005634 (EC: ISS); GO_0005654 (EC: TAS); GO_0006468 (EC: ISS); GO_0007399 (EC: TAS, PMID: 8769099); GO_0007623 (EC: ISS); GO_0016607 (EC: ISS); GO_0018105 (EC: IEA); GO_0018107 (EC: ISS); GO_0018108 (EC: IDA, PMID: 9748265); GO_0018108 (EC: ISS); GO_0030529 (EC: IEA); GO_0043518 (EC: ISS); GO_0043621 (EC: ISS); GO_0046777 (EC: ISS); GO_0048156 (EC: ISS); GO_0090312 (EC: ISS)
has PubMed association: PMID: 8274451; 8769099; 8872470; 8975710; 9037601; 9048932; 9284911; 9503011; 9503019; 9748265; 9784410; 10329007; 10644696; 10830953; 11311120; 11877424; 12138125; 12477932; 12576186; 12799418; 12964950; 14500717; 14593110; 14623875; 15068245; 15068246; 15126119; 15324660; 15369779; 15592455; 15694837; 15778465; 15917294; 16009940; 16242644; 16512921; 16733250; 16919501; 16959772; 17135279; 17145134; 17192257; 17229891; 17294446; 17536841; 17906291; 18005339; 18231969; 18366763; 18405873; 18468476; 18509201; 18658135; 18678649; 18696092; 18729074; 18771760; 19016842; 19081073; 19242551; 19322201; 19383720; 19722700; 19801542; 19995442; 20167603; 20237271; 20456003; 20694148; 20696760; 20940704; 21102440; 21126318; 21135538; 21139048; 21156027; 21156028; 21157379; 21205194; 21215488; 21252229; 21294719; 21364930; 21498570; 21498571; 21637297; 21777625; 21832049; 21878370; 21890473; 21965663; 22110360; 22154664; 22269890; 22354171; 22495309; 22669612; 22765017; 22767602; 22792062; 22876196; 22990118; 23099646; 23124096; 23147510; 23360763; 23382691; 23455922; 23512985; 23602568; 23635774; 24119401
description: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
database cross reference: Ensembl:ENSG00000157540
database cross reference: HGNC:3091
database cross reference: HPRD:09018
database cross reference: MIM:600855
database cross reference: Vega:OTTHUMG00000086657

ECE1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ECE
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ECE1
full name from nomenclature authority: endothelin converting enzyme 1
NCBI GeneID: 1889
NCBI LocusTag: RP3-329E20.1
gene map location: 1p36.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001921 (EC: IMP, PMID: 18039931); GO_0003100 (EC: IC, PMID: 7805846); GO_0004175 (EC: IDA, PMID: 18039931); GO_0004222 (EC: ISS, PMID: 8062389); GO_0005765 (EC: IDA, PMID: 17897319); GO_0005768 (EC: IDA, PMID: 18039931); GO_0005769 (EC: IDA, PMID: 18039931); GO_0005886 (EC: IDA, PMID: 18039931); GO_0007507 (EC: IMP, PMID: 9915973); GO_0009897 (EC: IDA, PMID: 9449382); GO_0010814 (EC: IDA, PMID: 18039931); GO_0010815 (EC: IDA, PMID: 18039931); GO_0010816 (EC: IDA, PMID: 18039931); GO_0016021 (EC: IDA, PMID: 7805846); GO_0016485 (EC: IDA, PMID: 7805846); GO_0016486 (EC: IDA, PMID: 7864876); GO_0017046 (EC: IC, PMID: 7864876); GO_0019229 (EC: IC, PMID: 7805846); GO_0031302 (EC: TAS, PMID: 18039931); GO_0031982 (EC: ISS, PMID: 9449382); GO_0033093 (EC: IDA, PMID: 9710124); GO_0034959 (EC: IDA, PMID: 7805846); GO_0042447 (EC: IDA, PMID: 7864876); GO_0042733 (EC: IMP, PMID: 9915973); GO_0042803 (EC: IPI, PMID: 7805846); GO_0043583 (EC: IMP, PMID: 9915973); GO_0046872 (EC: IEA); GO_0048471 (EC: IDA, PMID: 9710124); GO_0060037 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 7695628; 7805846; 7864876; 8062389; 8530372; 8641140; 8889548; 9253714; 9396733; 9449382; 9595387; 9710124; 9915973; 10438732; 10491078; 10620363; 10833511; 11723113; 11906289; 12011762; 12244060; 12393864; 12464614; 12477932; 12609744; 14597855; 15010576; 15126915; 15146197; 15240857; 15340356; 15342556; 15489334; 15665524; 16023075; 16234608; 16263699; 16289162; 16344560; 16526315; 16531800; 16567585; 16698938; 16710414; 16986361; 17081983; 17264805; 17295044; 17545092; 17592116; 17618613; 17664854; 17701914; 17712175; 17761169; 17897319; 17977716; 18029348; 18039931; 18334739; 18660489; 18781169; 18974277; 18992253; 19056867; 19222484; 19289136; 19531493; 19889475; 19913121; 20037208; 20301612; 20345647; 20346360; 20485444; 20538960; 20558134; 20628086; 20663017; 20725143; 21139048; 21554123; 21777246; 21851036; 21906983; 22027013; 22268729; 22322595; 22416137; 22693153; 22728136; 22731820; 22939629; 22972025; 23022525; 23175834; 23251661; 23283972
description: endothelin converting enzyme 1
database cross reference: Ensembl:ENSG00000117298
database cross reference: HGNC:3146
database cross reference: HPRD:02690
database cross reference: MIM:600423
database cross reference: Vega:OTTHUMG00000002625

EDN1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ARCND3
alternative term: ET1
alternative term: HDLCQ7
alternative term: PPET1
alternative term: QME
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: EDN1
full name from nomenclature authority: endothelin 1
NCBI GeneID: 1906
gene map location: 6p24.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IDA, PMID: 19767294); GO_0001516 (EC: IDA, PMID: 9492062); GO_0001569 (EC: IEA); GO_0001666 (EC: IEA); GO_0001701 (EC: IEA); GO_0001821 (EC: IEA); GO_0003100 (EC: IDA, PMID: 2649896); GO_0005125 (EC: IDA, PMID: 19767294); GO_0005179 (EC: IDA, PMID: 10770212); GO_0005515 (EC: IPI); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 10770212); GO_0005737 (EC: IDA, PMID: 12379507); GO_0006885 (EC: IEA); GO_0007166 (EC: IDA, PMID: 1713452); GO_0007186 (EC: IDA, PMID: 17078114); GO_0007204 (EC: IDA, PMID: 1917960); GO_0007205 (EC: IEA); GO_0007267 (EC: IDA, PMID: 12379507); GO_0007507 (EC: IEA); GO_0007585 (EC: IEA); GO_0007589 (EC: IEA); GO_0008284 (EC: IDA, PMID: 17078114); GO_0009953 (EC: IEA); GO_0010259 (EC: IEA); GO_0010460 (EC: IDA, PMID: 2649896); GO_0010595 (EC: TAS, PMID: 8999856); GO_0010613 (EC: IDA, PMID: 12847114); GO_0010870 (EC: IDA, PMID: 17178876); GO_0014032 (EC: IEA); GO_0014065 (EC: IDA, PMID: 17078114); GO_0014824 (EC: IDA, PMID: 8982507); GO_0014824 (EC: TAS, PMID: 1725334); GO_0014826 (EC: IDA, PMID: 9422810); GO_0015758 (EC: IEA); GO_0016049 (EC: IEA); GO_0019229 (EC: IEA); GO_0019233 (EC: IEA); GO_0019722 (EC: IDA, PMID: 10770212); GO_0030072 (EC: IDA, PMID: 10770212); GO_0030185 (EC: IDA, PMID: 16820593); GO_0030195 (EC: TAS, PMID: 16820593); GO_0030335 (EC: IDA, PMID: 9696419); GO_0030593 (EC: IDA, Qualifier: NOT, PMID: 9696419); GO_0030818 (EC: IEA); GO_0031583 (EC: IEA); GO_0031707 (EC: IDA, PMID: 10770212); GO_0031708 (EC: IDA, PMID: 10770212); GO_0032269 (EC: IDA, PMID: 19767294); GO_0032496 (EC: IEA); GO_0033574 (EC: IEA); GO_0034392 (EC: IEA); GO_0035094 (EC: IEA); GO_0035810 (EC: IEA); GO_0035815 (EC: IEA); GO_0042045 (EC: IEA); GO_0042310 (EC: IDA, PMID: 11410113); GO_0042313 (EC: IDA, PMID: 16820593); GO_0042474 (EC: IEA); GO_0042482 (EC: IEA); GO_0042554 (EC: IEA); GO_0043179 (EC: IEA); GO_0043200 (EC: IEA); GO_0043406 (EC: IDA, PMID: 10770212); GO_0043507 (EC: IDA, PMID: 12847114); GO_0045321 (EC: TAS, PMID: 16820593);…
has PubMed association: PMID: 1280264; 1422154; 1515112; 1713452; 1725334; 1736987; 1859417; 1864385; 1917960; 2005113; 2018043; 2201681; 2649896; 2659594; 2670930; 2678110; 3282927; 7509919; 7664037; 7773179; 8125160; 8144511; 8450044; 8482849; 8889548; 8982507; 8999856; 9257865; 9284755; 9324057; 9422810; 9453574; 9492062; 9595387; 9696419; 10220569; 10231710; 10334806; 10391210; 10393673; 10438732; 10620363; 10770212; 11179511; 11210078; 11399938; 11410113; 11448123; 11593097; 11601839; 11693192; 11742499; 11751711; 11795667; 11831453; 11858185; 11866544; 11932487; 11934840; 11991554; 11991733; 12009599; 12011762; 12013496; 12068797; 12077518; 12082592; 12087564; 12107733; 12117726; 12137974; 12144123; 12151765; 12189238; 12230494; 12379507; 12446192; 12459174; 12477932; 12508654; 12511547; 12529269; 12557940; 12565798; 12588850; 12620701; 12629276; 12657945; 12695528; 12721154; 12746758; 12750312; 12847114; 12855940; 12861161; 12887757; 12907686; 12941866; 12963677; 12972292; 13680553; 14514737; 14519635; 14523636; 14558091; 14574404; 14578413; 14587645; 14602502; 14634722; 14636060; 14639018; 14660616; 14685288; 14692644; 14733410; 14735061; 14736087; 14763917; 14769714; 15009217; 15041798; 15044479; 15047866; 15073116; 15093707; 15126915; 15139053; 15161426; 15188945; 15194301; 15198485; 15213100; 15224360; 15240857; 15269821; 15319532; 15347673; 15369130; 15466627; 15481145; 15489334; 15505112; 15518541; 15558022; 15568807; 15610525; 15621731; 15623376; 15643502; 15646831; 15652492; 15691296; 15699938; 15702240; 15743480; 15817494; 15818445; 15838269; 15838299; 15838323; 15838328; 15838333; 15838334; 15838336; 15838337; 15838340; 15838344; 15838351; 15838357; 15838368; 15838369; 15838370; 15864745; 15946241; 15946919; 15979050; 15988412; 16002759; 16021085; 16026642; 16076689; 16095497; 16097909; 16098041; 16169070; 16217751; 16234608; 16291872; 16320159; 16336267; 16357176; 16452160; 16466695; 16521405; 16526196; 16531800; 16582543; 16597412; 16648553; 16713569; 16720059; 16754659;…
description: endothelin 1
database cross reference: Ensembl:ENSG00000078401
database cross reference: HGNC:3176
database cross reference: HPRD:07030
database cross reference: MIM:131240
database cross reference: Vega:OTTHUMG00000014266

EGF
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HOMG4
alternative term: URG
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: EGF
full name from nomenclature authority: epidermal growth factor
NCBI GeneID: 1950
gene map location: 4q25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000186 (EC: IEA); GO_0001525 (EC: IDA, PMID: 15611079); GO_0002576 (EC: TAS); GO_0005154 (EC: TAS, PMID: 15611079); GO_0005509 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12297050); GO_0005576 (EC: IC, PMID: 9712850); GO_0005576 (EC: TAS); GO_0005615 (EC: IEA); GO_0005765 (EC: IDA, PMID: 17897319); GO_0005886 (EC: IEA); GO_0006260 (EC: TAS, PMID: 9482941); GO_0007165 (EC: TAS); GO_0007171 (EC: TAS, PMID: 9712850); GO_0007173 (EC: TAS); GO_0007262 (EC: ISS); GO_0007596 (EC: TAS); GO_0008083 (EC: IDA, PMID: 15611079); GO_0008284 (EC: IDA, PMID: 15611079); GO_0008543 (EC: TAS); GO_0010800 (EC: IDA, PMID: 16314496); GO_0016021 (EC: IEA); GO_0018108 (EC: IEA); GO_0021940 (EC: IEA); GO_0030168 (EC: TAS); GO_0030297 (EC: TAS, PMID: 9712850); GO_0031093 (EC: TAS); GO_0035413 (EC: IDA); GO_0038095 (EC: TAS); GO_0042059 (EC: TAS); GO_0042327 (EC: IDA, PMID: 15611079); GO_0043388 (EC: ISS); GO_0043406 (EC: IDA, PMID: 15611079); GO_0045087 (EC: TAS); GO_0045741 (EC: IDA, PMID: 15611079); GO_0045741 (EC: TAS, PMID: 9712850); GO_0045840 (EC: IDA, PMID: 15611079); GO_0045893 (EC: IDA, PMID: 16314496); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0048754 (EC: IEA); GO_0051048 (EC: IDA, PMID: 10559227); GO_0060749 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070371 (EC: IDA, PMID: 16314496); GO_0090279 (EC: IDA, PMID: 19996314); GO_0090370 (EC: IEA); GO_1900127 (EC: IDA, PMID: 17324121); GO_2000008 (EC: IDA, PMID: 19996314); GO_2000060 (EC: IEA)
has PubMed association: PMID: 300079; 1281549; 1334406; 1501243; 1522591; 1639032; 2789514; 2790960; 3486749; 3491360; 6290982; 6382023; 6603475; 7540053; 7558411; 7615511; 7640657; 7730382; 7736574; 8077234; 8123596; 8413296; 8419140; 8639530; 8796265; 8845374; 9188692; 9356464; 9482941; 9544989; 9661876; 9687510; 9712850; 9925763; 10085134; 10199559; 10436156; 10559227; 10567358; 10579352; 10648629; 10734310; 10748174; 10788520; 10913131; 10973965; 11438527; 11751923; 11786904; 11796824; 11823423; 11844511; 11894095; 11896055; 11903419; 11914075; 11925427; 11950840; 11971908; 11994282; 12009575; 12093292; 12138086; 12141529; 12163055; 12163506; 12192610; 12202942; 12218189; 12297050; 12368284; 12388817; 12397374; 12425525; 12477932; 12508124; 12531699; 12540376; 12593796; 12620237; 12637502; 12643788; 12667326; 12672817; 12722480; 12768436; 12788694; 12795334; 12879019; 12954631; 12960147; 14507446; 14520709; 14523024; 14560030; 14614718; 14651960; 14662770; 14665621; 14676838; 15003992; 15063762; 15081423; 15087376; 15129177; 15175028; 15180992; 15183666; 15192046; 15194442; 15252009; 15256384; 15260478; 15272014; 15329330; 15373781; 15373782; 15373802; 15475003; 15481560; 15485655; 15485674; 15488707; 15489334; 15491342; 15509542; 15536154; 15574420; 15611079; 15613483; 15620700; 15622242; 15659382; 15663953; 15675968; 15729146; 15735691; 15748906; 15798095; 15802268; 15837620; 15860930; 15886816; 15901830; 15913871; 15950078; 15950906; 15962011; 15982634; 16019439; 16033767; 16115648; 16134968; 16210470; 16214932; 16248985; 16274239; 16274250; 16282324; 16314496; 16316319; 16332692; 16344560; 16407418; 16407834; 16413767; 16428382; 16436184; 16584205; 16636672; 16691190; 16728406; 16762922; 16788380; 16820871; 16837648; 16847055; 16872636; 16885506; 16939220; 16946702; 16969495; 16979250; 17123472; 17175377; 17204151; 17223314; 17227756; 17311928; 17316357; 17324121; 17334773; 17392355; 17397984; 17433039; 17453000; 17473192; 17479438; 17545148; 17562024; 17567965; 17573555; 17578349;…
description: epidermal growth factor
database cross reference: Ensembl:ENSG00000138798
database cross reference: HGNC:3229
database cross reference: HPRD:00578
database cross reference: MIM:131530
database cross reference: Vega:OTTHUMG00000132044

EGFR
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ERBB
alternative term: ERBB1
alternative term: HER1
alternative term: PIG61
alternative term: mENA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: EGFR
full name from nomenclature authority: epidermal growth factor receptor
NCBI GeneID: 1956
gene map location: 7p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: IEA); GO_0000165 (EC: NAS, PMID: 15542601); GO_0001503 (EC: NAS, PMID: 12925580); GO_0001889 (EC: IEA); GO_0001892 (EC: IEA); GO_0001934 (EC: IDA); GO_0001942 (EC: IEA); GO_0001948 (EC: IEA); GO_0003682 (EC: IDA); GO_0003690 (EC: NAS, PMID: 6325948); GO_0004709 (EC: NAS, PMID: 15542601); GO_0004713 (EC: IDA, PMID: 17115032); GO_0004713 (EC: IMP, PMID: 14702346); GO_0004713 (EC: TAS, PMID: 16076471); GO_0004714 (EC: TAS); GO_0004716 (EC: IEA); GO_0004888 (EC: IDA, PMID: 7736574); GO_0005006 (EC: IDA, PMID: 12435727); GO_0005006 (EC: NAS, PMID: 2790960); GO_0005178 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10026169); GO_0005524 (EC: IEA); GO_0005615 (EC: NAS, PMID: 9103388); GO_0005634 (EC: IDA, PMID: 12828935); GO_0005737 (EC: IDA); GO_0005768 (EC: IDA, PMID: 14702346); GO_0005789 (EC: IEA); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0005976 (EC: IEA); GO_0006412 (EC: IEA); GO_0006950 (EC: NAS, PMID: 12828935); GO_0006970 (EC: IEA); GO_0006979 (EC: IEA); GO_0007165 (EC: IDA, PMID: 10572067); GO_0007165 (EC: TAS); GO_0007166 (EC: IDA, PMID: 7736574); GO_0007173 (EC: IDA, PMID: 12435727); GO_0007173 (EC: TAS); GO_0007202 (EC: TAS, PMID: 12435727); GO_0007411 (EC: TAS); GO_0007435 (EC: IEA); GO_0007611 (EC: ISS); GO_0007623 (EC: IEA); GO_0008283 (EC: IDA, PMID: 17115032); GO_0008284 (EC: IDA, PMID: 7736574); GO_0008543 (EC: TAS); GO_0009986 (EC: IEA); GO_0010008 (EC: IEA); GO_0010960 (EC: IEA); GO_0016020 (EC: IDA, PMID: 12435727); GO_0016021 (EC: IEA); GO_0016101 (EC: IEA); GO_0016323 (EC: IDA, PMID: 12646923); GO_0016324 (EC: IEA); GO_0016337 (EC: IMP, PMID: 12435727); GO_0018108 (EC: IDA, PMID: 17115032); GO_0018108 (EC: IMP, PMID: 14702346); GO_0018108 (EC: TAS, PMID: 16076471); GO_0019694 (EC: IEA); GO_0019899 (EC: IPI, PMID: 12009895); GO_0019901 (EC: IEA); GO_0019903 (EC: IPI, PMID: 15899872); GO_0021795 (EC: IEA); GO_0030122 (EC: TAS, Qualifier: colocalizes_with, PMID: 14702346); GO_0030235 (EC: IDA, Qualifier: contributes_to, PMID: 12828935); GO…
has PubMed association: PMID: 1281549; 1301150; 1309762; 1322798; 1333047; 1372092; 1382070; 1383230; 1385407; 1501243; 1505215; 1623525; 1633149; 1647028; 1651322; 1689310; 1706616; 1808202; 1850098; 1988448; 2173144; 2176151; 2434500; 2543678; 2543683; 2790960; 2810532; 2984676; 2985580; 2987962; 2991749; 2991899; 3039909; 3138233; 3329716; 6093780; 6297856; 6324343; 6325948; 6326261; 6328312; 6330563; 7506413; 7510700; 7518560; 7527043; 7532293; 7535770; 7540771; 7543024; 7588596; 7592693; 7623846; 7640657; 7654368; 7657591; 7657660; 7673163; 7682059; 7690989; 7730382; 7736574; 7761838; 7782294; 7880396; 7903710; 8125298; 8305738; 8375396; 8413296; 8493579; 8497321; 8577769; 8596488; 8610109; 8610433; 8621392; 8638121; 8639530; 8647288; 8647858; 8650580; 8657103; 8662998; 8702572; 8729040; 8798643; 8810325; 8845374; 8875975; 8885868; 8887653; 8918811; 8940083; 8943228; 8962717; 9006901; 9049247; 9050991; 9079622; 9103388; 9115287; 9121472; 9130710; 9188692; 9207933; 9233779; 9307968; 9344857; 9346925; 9355745; 9356464; 9362449; 9363897; 9374534; 9416834; 9419975; 9425043; 9430697; 9447973; 9480911; 9488479; 9506989; 9506992; 9507002; 9528863; 9535896; 9544989; 9556602; 9617486; 9642287; 9658162; 9710451; 9733788; 9737977; 9756944; 9781061; 9815893; 9819414; 9837959; 9843575; 9872323; 9886492; 9890970; 9988678; 10026169; 10049786; 10075741; 10085134; 10086340; 10092522; 10187783; 10347170; 10358079; 10362357; 10369675; 10428778; 10435588; 10508618; 10523301; 10527633; 10558875; 10567358; 10571044; 10572067; 10595738; 10617627; 10618391; 10635327; 10648629; 10675333; 10722725; 10731668; 10734107; 10734310; 10777553; 10788520; 10799548; 10805725; 10806474; 10861448; 10888683; 10889023; 10913131; 10918300; 10918587; 10938113; 10953014; 10969083; 10971656; 10980697; 10985391; 10993906; 11094073; 11114724; 11116146; 11161793; 11172806; 11223155; 11226410; 11239464; 11278868; 11279102; 11286993; 11294897; 11349134; 11370743; 11375397; 11408594; 11432805; 11459228; 11467954; 11470832; 11483589;…
description: epidermal growth factor receptor
database cross reference: Ensembl:ENSG00000146648
database cross reference: HGNC:3236
database cross reference: HPRD:00579
database cross reference: MIM:131550
database cross reference: Vega:OTTHUMG00000023661

EIF4EBP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: 4E-BP1
alternative term: 4EBP1
alternative term: BP-1
alternative term: PHAS-I
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: EIF4EBP1
full name from nomenclature authority: eukaryotic translation initiation factor 4E binding protein 1
NCBI GeneID: 1978
gene map location: 8p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000082 (EC: IMP, PMID: 14673156); GO_0002931 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10772338); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0006412 (EC: TAS); GO_0006413 (EC: TAS); GO_0008190 (EC: IEA); GO_0008286 (EC: TAS); GO_0010467 (EC: TAS); GO_0030324 (EC: IEA); GO_0030371 (EC: IDA); GO_0031333 (EC: IEA); GO_0031929 (EC: IDA, PMID: 12150926); GO_0043234 (EC: IEA); GO_0044267 (EC: TAS); GO_0045471 (EC: IEA); GO_0045931 (EC: IMP, PMID: 14673156); GO_0045947 (EC: IDA)
has PubMed association: PMID: 7651417; 7935836; 8083223; 8521827; 8816458; 8957083; 8975712; 9092573; 9344920; 9405468; 9465032; 9628874; 9806882; 10022874; 10092805; 10198256; 10364159; 10405182; 10608806; 10698949; 10713094; 10753870; 10772338; 10779345; 10942774; 10971657; 11069026; 11114166; 11146653; 11280764; 11438723; 11553333; 11605658; 11691836; 11777913; 11847216; 11865047; 11909977; 12071973; 12080086; 12105188; 12150925; 12150926; 12151318; 12271141; 12477932; 12588975; 12604610; 12618431; 12665511; 12665801; 12747827; 12759354; 12820960; 12912989; 14507920; 14673156; 15066126; 15094042; 15153109; 15178440; 15459249; 15467718; 15489334; 15542544; 15767663; 15809305; 15854902; 15927069; 16098202; 16098514; 16109716; 16169070; 16189514; 16242075; 16271312; 16648488; 16652388; 16715128; 16798736; 16824195; 16837165; 16873412; 16899564; 16983702; 17081983; 17114181; 17200342; 17254965; 17316564; 17353931; 17386266; 17502379; 17601486; 17604271; 17653084; 17693255; 17699757; 17724476; 18029348; 18051367; 18280804; 18337562; 18337751; 18384376; 18439897; 18442140; 18660489; 18668138; 18701920; 18708753; 18722121; 18810319; 18922789; 18957614; 19036825; 19107520; 19211763; 19244480; 19271249; 19336517; 19360336; 19367274; 19428047; 19429661; 19533653; 19541645; 19574449; 19603014; 19648884; 19834456; 19850923; 20090955; 20133758; 20304964; 20372058; 20532202; 20609351; 20621385; 20671708; 21046149; 21067588; 21071439; 21366462; 21460630; 21576371; 21661078; 21750861; 21784851; 21841310; 21900206; 21913890; 21914810; 21922152; 21964297; 22110663; 22142830; 22178476; 22184107; 22216185; 22248270; 22457629; 22493283; 22578813; 22586265; 22641346; 22652449; 22690797; 22918237; 22977662; 23082216; 23100465; 23175522; 23340172; 23451476; 23547259; 23640516; 23707523; 23814053; 24030155; 24211447; 24255178
description: eukaryotic translation initiation factor 4E binding protein 1
database cross reference: Ensembl:ENSG00000187840
database cross reference: HGNC:3288
database cross reference: HPRD:03746
database cross reference: MIM:602223
database cross reference: Vega:OTTHUMG00000164012

EPHA1
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: EPH
alternative term: EPHT
alternative term: EPHT1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: EPHA1
full name from nomenclature authority: EPH receptor A1
NCBI GeneID: 2041
gene map location: 7q34
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001525 (EC: IEA); GO_0001954 (EC: IDA, PMID: 19118217); GO_0004672 (EC: IDA, PMID: 12775584); GO_0005005 (EC: IDA, PMID: 19118217); GO_0005524 (EC: IEA); GO_0005887 (EC: IDA, PMID: 19118217); GO_0006469 (EC: IDA, PMID: 19118217); GO_0007166 (EC: IDA, PMID: 19118217); GO_0008284 (EC: IMP); GO_0018108 (EC: IDA, PMID: 12775584); GO_0019901 (EC: IPI, PMID: 19118217); GO_0030335 (EC: IMP); GO_0030336 (EC: IDA, PMID: 19118217); GO_0032314 (EC: IDA, PMID: 19118217); GO_0032862 (EC: IDA, PMID: 19118217); GO_0034446 (EC: IDA, PMID: 19118217); GO_0045766 (EC: IMP); GO_0046777 (EC: IDA, PMID: 19118217); GO_0051496 (EC: ISS)
has PubMed association: PMID: 2825356; 8755474; 9267020; 9530499; 9576626; 10207129; 10369740; 10502115; 10730216; 11128993; 11256076; 11519828; 12477932; 12775584; 12853948; 14968112; 15146197; 15761153; 15951569; 16344560; 16737551; 16862074; 16964243; 17980912; 18308734; 18566674; 18590698; 18593464; 18728013; 18802966; 18990944; 19011600; 19118217; 19277044; 19525919; 19913121; 19949912; 20043122; 20596523; 20628086; 21042754; 21460840; 21460841; 21503576; 21906983; 22261062; 22362770; 22688511; 22939624; 23030051; 23429488
description: EPH receptor A1
database cross reference: Ensembl:ENSG00000146904
database cross reference: HGNC:3385
database cross reference: HPRD:01554
database cross reference: MIM:179610
database cross reference: Vega:OTTHUMG00000155894

ERN1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IRE1
alternative term: IRE1P
alternative term: IRE1a
alternative term: hIRE1p
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ERN1
full name from nomenclature authority: endoplasmic reticulum to nucleus signaling 1
NCBI GeneID: 2081
gene map location: 17q24.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000287 (EC: IDA, PMID: 9637683); GO_0004521 (EC: IDA, PMID: 11779465); GO_0004521 (EC: TAS); GO_0004674 (EC: IDA, PMID: 9637683); GO_0004674 (EC: TAS); GO_0005515 (EC: IPI, PMID: 11278723); GO_0005524 (EC: IDA, PMID: 9637683); GO_0005637 (EC: IEA); GO_0005739 (EC: IEA); GO_0005789 (EC: TAS); GO_0006351 (EC: IEA); GO_0006355 (EC: IEA); GO_0006468 (EC: IDA, PMID: 9637683); GO_0006987 (EC: IDA, PMID: 9637683); GO_0006987 (EC: TAS); GO_0007050 (EC: ISS); GO_0019899 (EC: IPI); GO_0030176 (EC: IDA, PMID: 9637683); GO_0030968 (EC: TAS); GO_0042802 (EC: IPI, PMID: 12637535); GO_0044267 (EC: TAS); GO_0046777 (EC: IEA); GO_0070055 (EC: IDA, PMID: 11779465); GO_0070059 (EC: IEA); GO_0090502 (EC: IDA, PMID: 11779465); GO_0090502 (EC: TAS); GO_1900103 (EC: IMP, PMID: 16645094)
has PubMed association: PMID: 9637683; 10587643; 10650002; 10737800; 11175748; 11278723; 11779465; 11850408; 11897784; 12050113; 12446770; 12477932; 12637535; 12843613; 14702039; 15063770; 15234121; 16107700; 16344560; 16645094; 16680093; 17585877; 17638880; 17951406; 17991856; 18065414; 18242182; 18369366; 18840095; 19135427; 19913121; 20007910; 20013084; 20103773; 20379614; 20447464; 20625543; 20628086; 20702765; 20798350; 20819778; 20965234; 21118962; 21385877; 21482118; 21525936; 21680894; 21954231; 22194594; 22199355; 22219383; 22314839; 22315414; 22419015; 22446326; 22718352; 22787145; 22917505; 23001845; 23041190; 23042294; 23103912; 23110043; 23363253; 23575540; 23598528; 23602568; 23684307; 23748775; 23752693; 23942232; 23950715; 24330607
description: endoplasmic reticulum to nucleus signaling 1
database cross reference: Ensembl:ENSG00000178607
database cross reference: HGNC:3449
database cross reference: HPRD:04943
database cross reference: MIM:604033
database cross reference: Vega:OTTHUMG00000178879

ESR1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ER
alternative term: ESR
alternative term: ESRA
alternative term: ESTRR
alternative term: Era
alternative term: NR3A1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ESR1
full name from nomenclature authority: estrogen receptor 1
NCBI GeneID: 2099
NCBI LocusTag: RP1-130E4.1
gene map location: 6q25.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001046 (EC: IDA, PMID: 15345745); GO_0001547 (EC: IEA); GO_0002064 (EC: IEA); GO_0003682 (EC: IEA); GO_0003700 (EC: NAS, PMID: 12552091); GO_0003707 (EC: TAS, PMID: 10749889); GO_0005496 (EC: ISS); GO_0005515 (EC: IPI, PMID: 10359819); GO_0005634 (EC: IDA, PMID: 15569929); GO_0005654 (EC: TAS); GO_0005794 (EC: IEA); GO_0005886 (EC: IDA, PMID: 15569929); GO_0006338 (EC: NAS, PMID: 12351687); GO_0006351 (EC: TAS, PMID: 2040605); GO_0006355 (EC: NAS, PMID: 3753802); GO_0006367 (EC: TAS); GO_0007165 (EC: TAS, PMID: 10749889); GO_0007200 (EC: ISS); GO_0007204 (EC: ISS); GO_0008013 (EC: IPI, PMID: 15304487); GO_0008134 (EC: IEA); GO_0008209 (EC: IEA); GO_0008270 (EC: IEA); GO_0008584 (EC: IEA); GO_0010467 (EC: TAS); GO_0010629 (EC: IDA); GO_0010863 (EC: ISS); GO_0016020 (EC: NAS, PMID: 11960618); GO_0016021 (EC: IEA); GO_0019899 (EC: IPI, PMID: 12039952); GO_0030235 (EC: NAS, PMID: 12389206); GO_0030284 (EC: NAS, PMID: 3753802); GO_0030518 (EC: ISS); GO_0030520 (EC: NAS, PMID: 3753802); GO_0032355 (EC: IDA, PMID: 15304487); GO_0034056 (EC: IDA, PMID: 15345745); GO_0038052 (EC: IGI, PMID: 18722177); GO_0042802 (EC: IPI, PMID: 11265755); GO_0042981 (EC: IEA); GO_0043124 (EC: IDA, PMID: 16043358); GO_0043433 (EC: IDA, PMID: 10816575); GO_0043627 (EC: IDA, PMID: 11581164); GO_0045429 (EC: IDA); GO_0045944 (EC: IDA, PMID: 15345745); GO_0048146 (EC: IEA); GO_0048386 (EC: IDA, PMID: 15831516); GO_0051000 (EC: IDA); GO_0051091 (EC: IDA, PMID: 10681512); GO_0060065 (EC: IEA); GO_0060068 (EC: IEA); GO_0060523 (EC: IEA); GO_0060527 (EC: IEA); GO_0060687 (EC: IEA); GO_0060745 (EC: IEA); GO_0060749 (EC: IEA); GO_0060750 (EC: IEA); GO_0071392 (EC: ISS)
has PubMed association: PMID: 1476547; 1567414; 1577818; 1603086; 1779972; 2015052; 2040605; 2247153; 2792078; 3145193; 3753802; 3754034; 7476978; 7539106; 7641693; 7651415; 7838153; 7916651; 7923369; 8090165; 8221895; 8240974; 8308015; 8406468; 8524784; 8541239; 8598193; 8600444; 8600466; 8616895; 8647321; 8887632; 8961262; 9039267; 9058380; 9099865; 9115274; 9121466; 9171229; 9171231; 9192892; 9192902; 9195227; 9222609; 9259327; 9328340; 9338790; 9346901; 9393949; 9395481; 9427757; 9430642; 9448000; 9473491; 9489701; 9528769; 9600906; 9619507; 9627117; 9628876; 9628887; 9632676; 9653119; 9702189; 9710597; 9717844; 9765300; 9773978; 9773983; 9774463; 9774640; 9817600; 9841876; 9849967; 9875847; 9891036; 9892017; 10022127; 10085091; 10207098; 10334989; 10359819; 10428798; 10446910; 10454579; 10480874; 10490106; 10567404; 10598586; 10598587; 10619354; 10620335; 10648597; 10681512; 10706293; 10706618; 10706629; 10707955; 10713182; 10731636; 10737800; 10748020; 10749889; 10760302; 10766163; 10770935; 10816575; 10829018; 10866662; 10872826; 10903152; 10908561; 10938099; 10949034; 10970861; 11003650; 11004670; 11013076; 11014206; 11018265; 11029009; 11032808; 11043578; 11050077; 11050174; 11053406; 11073968; 11092403; 11092404; 11113179; 11113208; 11117529; 11121195; 11127213; 11139535; 11139588; 11140838; 11146623; 11149476; 11165056; 11178989; 11231990; 11239543; 11244506; 11250900; 11265755; 11266503; 11279242; 11316004; 11353774; 11355046; 11358671; 11358960; 11369763; 11376110; 11383910; 11389589; 11397855; 11429412; 11432835; 11435445; 11436125; 11437591; 11458981; 11458983; 11477071; 11481323; 11493692; 11507039; 11525424; 11555647; 11563984; 11564035; 11564893; 11574675; 11581164; 11591700; 11595700; 11595744; 11682624; 11682626; 11689445; 11689696; 11696545; 11704680; 11710886; 11716992; 11720251; 11731608; 11765043; 11773069; 11773441; 11773443; 11773444; 11774719; 11779858; 11782371; 11792840; 11795466; 11798902; 11803451; 11818499; 11818702; 11823467; 11826769; 11836633; 11838047; 1…
description: estrogen receptor 1
database cross reference: Ensembl:ENSG00000091831
database cross reference: HGNC:3467
database cross reference: HPRD:00589
database cross reference: MIM:133430
database cross reference: Vega:OTTHUMG00000016103

PTK2B
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CADTK
alternative term: CAKB
alternative term: FADK2
alternative term: FAK2
alternative term: PKB
alternative term: PTK
alternative term: PYK2
alternative term: RAFTK
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PTK2B
full name from nomenclature authority: protein tyrosine kinase 2 beta
NCBI GeneID: 2185
gene map location: 8p21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: IEA); GO_0001556 (EC: IEA); GO_0001666 (EC: IEA); GO_0001954 (EC: IMP, PMID: 18765415); GO_0002040 (EC: ISS); GO_0002315 (EC: ISS); GO_0004713 (EC: TAS, PMID: 8939945); GO_0004715 (EC: IDA, PMID: 7544443); GO_0004871 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10521452); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0005886 (EC: IEA); GO_0005925 (EC: IDA, PMID: 18765415); GO_0005938 (EC: IEA); GO_0006461 (EC: TAS, PMID: 10867021); GO_0006468 (EC: TAS, PMID: 7529876); GO_0006915 (EC: TAS, PMID: 10880513); GO_0006950 (EC: TAS, PMID: 8939945); GO_0006970 (EC: IEA); GO_0007165 (EC: TAS, PMID: 10867021); GO_0007166 (EC: IMP, PMID: 8849729); GO_0007172 (EC: IEA); GO_0007173 (EC: IEA); GO_0007204 (EC: IEA); GO_0007229 (EC: IMP, PMID: 15050747); GO_0008284 (EC: IMP, PMID: 18765415); GO_0008285 (EC: IMP, PMID: 15050747); GO_0008360 (EC: IMP, PMID: 19086031); GO_0009612 (EC: IEA); GO_0009725 (EC: IEA); GO_0009749 (EC: IEA); GO_0010226 (EC: IEA); GO_0010595 (EC: IDA); GO_0010656 (EC: IEA); GO_0010752 (EC: IEA); GO_0010758 (EC: ISS); GO_0010976 (EC: IMP, PMID: 17910947); GO_0014009 (EC: IEA); GO_0014069 (EC: IEA); GO_0018108 (EC: IDA, PMID: 7544443); GO_0030027 (EC: IDA, PMID: 18765415); GO_0030155 (EC: IMP, PMID: 19086031); GO_0030307 (EC: IEA); GO_0030335 (EC: IMP, PMID: 18765415); GO_0030424 (EC: IEA); GO_0030426 (EC: IEA); GO_0030502 (EC: ISS); GO_0030826 (EC: IEA); GO_0030838 (EC: IMP, PMID: 18765415); GO_0031175 (EC: IEA); GO_0032403 (EC: IEA); GO_0032863 (EC: IEA); GO_0032960 (EC: ISS); GO_0033209 (EC: IMP, PMID: 8670418); GO_0042220 (EC: IEA); GO_0042493 (EC: IEA); GO_0042542 (EC: IEA); GO_0042976 (EC: IMP, PMID: 8670418); GO_0043066 (EC: IMP, PMID: 19880522); GO_0043149 (EC: IEA); GO_0043267 (EC: IDA, PMID: 7544443); GO_0043423 (EC: IEA); GO_0043507 (EC: IEA); GO_0043534 (EC: IEA); GO_0043552 (EC: ISS); GO_0045121 (EC: IEA); GO_0045428 (EC: IEA); GO_0045453 (EC: ISS); GO_004547…
has PubMed association: PMID: 1718748; 7499242; 7529876; 7544443; 7673154; 8497321; 8670418; 8792832; 8798684; 8838818; 8849729; 8889548; 8939945; 8995252; 9020138; 9091579; 9099734; 9104812; 9242628; 9344848; 9362541; 9402324; 9422762; 9442086; 9446638; 9512511; 9545257; 9560226; 9565592; 9621077; 9750131; 9858471; 10022914; 10022920; 10082674; 10194422; 10229084; 10322114; 10329689; 10354709; 10356363; 10518561; 10521452; 10702271; 10708762; 10713673; 10747947; 10769033; 10777553; 10797305; 10821841; 10867021; 10880513; 10961871; 10980697; 11007796; 11036077; 11149930; 11162638; 11238453; 11278472; 11311138; 11337490; 11352632; 11461120; 11478920; 11493697; 11668182; 11683411; 11739373; 11744621; 11751905; 11774117; 11818507; 11820787; 11850124; 11856738; 11916084; 11937718; 12011061; 12063569; 12077257; 12082274; 12096713; 12231407; 12244133; 12354773; 12458207; 12477932; 12486027; 12515814; 12522270; 12576483; 12578912; 12606503; 12626562; 12628756; 12629171; 12771146; 12771190; 12794117; 12844492; 12857973; 12893833; 12933673; 12943720; 12960231; 14585963; 14676843; 14684825; 14729602; 14961028; 14963038; 14969582; 15050747; 15070849; 15105428; 15128501; 15128873; 15213840; 15489334; 15494733; 15499613; 15539082; 15557335; 15585656; 15588985; 15695828; 15717329; 15778498; 15835820; 15881658; 15944312; 15967096; 16055703; 16202977; 16344560; 16421571; 16433632; 16514607; 16751776; 16760434; 16774943; 16783820; 16840719; 16945503; 16949788; 16998626; 17192257; 17205062; 17329398; 17512525; 17537919; 17551499; 17563746; 17581868; 17716864; 17785844; 17906699; 17910947; 17950644; 18029348; 18075463; 18086875; 18198130; 18365874; 18367725; 18390748; 18437915; 18453587; 18507841; 18571765; 18632858; 18667434; 18765415; 18794150; 18832579; 18954908; 19047047; 19086031; 19106639; 19207108; 19358827; 19380485; 19415692; 19458494; 19509258; 19561089; 19661918; 19700666; 19706888; 19718025; 19880522; 19913121; 19919693; 19930834; 20028775; 20056178; 20074345; 20180987; 20215112; 20308428; 203796…
description: protein tyrosine kinase 2 beta
database cross reference: Ensembl:ENSG00000120899
database cross reference: HGNC:9612
database cross reference: HPRD:03131
database cross reference: MIM:601212
database cross reference: Vega:OTTHUMG00000102082

FDFT1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DGPT
alternative term: ERG9
alternative term: SQS
alternative term: SS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: FDFT1
full name from nomenclature authority: farnesyl-diphosphate farnesyltransferase 1
NCBI GeneID: 2222
gene map location: 8p23.1-p22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004310 (EC: TAS); GO_0005783 (EC: IDA); GO_0005789 (EC: TAS); GO_0006694 (EC: TAS, PMID: 8474436); GO_0006695 (EC: TAS); GO_0008299 (EC: IEA); GO_0016021 (EC: IEA); GO_0016491 (EC: IEA); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0045338 (EC: IEA); GO_0051996 (EC: IEA)
has PubMed association: PMID: 7665618; 7685352; 7864626; 8020937; 8294001; 8474436; 10896663; 12477932; 14702039; 15489334; 16169070; 16684881; 17353931; 17483544; 17805225; 18029348; 18350552; 18636124; 18660489; 18676367; 19054015; 19245693; 19470168; 19738201; 19913121; 20031551; 20180986; 20403997; 20554694; 20628086; 20708005; 21139048; 21439984; 21890473; 21906983; 21945151; 21963094; 21987572; 22053931; 22268729; 22505724; 22546838; 22797925; 23000965; 23246001; 23455922; 23557589; 23752268; 23864651; 23956138; 24333579
description: farnesyl-diphosphate farnesyltransferase 1
database cross reference: Ensembl:ENSG00000079459
database cross reference: HGNC:3629
database cross reference: HPRD:01694
database cross reference: MIM:184420
database cross reference: Vega:OTTHUMG00000090801

FDPS
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FPPS
alternative term: FPS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: FDPS
full name from nomenclature authority: farnesyl diphosphate synthase
NCBI GeneID: 2224
gene map location: 1q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004161 (EC: IEA); GO_0004337 (EC: IEA); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005739 (EC: IEA); GO_0005829 (EC: TAS); GO_0006695 (EC: TAS); GO_0016032 (EC: IEA); GO_0033384 (EC: IEA); GO_0044281 (EC: TAS); GO_0044822 (EC: IDA); GO_0045337 (EC: IEA); GO_0046872 (EC: IEA)
has PubMed association: PMID: 1968462; 2018485; 2690933; 7584026; 8188698; 9030588; 10620343; 11160603; 11773414; 11785983; 12020352; 12107413; 12477932; 14702039; 15146197; 15342556; 15713990; 16344560; 16650801; 16684881; 16713569; 17198737; 17368768; 17387528; 17963374; 18029348; 18325729; 18327899; 18494934; 18660489; 18687167; 18781797; 19056481; 19060904; 19471022; 19494338; 20191015; 20450493; 20877624; 21139048; 21151198; 21196316; 21890473; 21906983; 21963094; 21987572; 22053931; 22278941; 22338925; 22407328; 22505724; 22863883; 23000965; 23234314; 23277274; 23847096; 23956138; 23998921; 24250222
description: farnesyl diphosphate synthase
database cross reference: Ensembl:ENSG00000160752
database cross reference: HGNC:3631
database cross reference: HPRD:00606
database cross reference: MIM:134629
database cross reference: Vega:OTTHUMG00000013909

FOXO1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FKH1
alternative term: FKHR
alternative term: FOXO1A
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: FOXO1
full name from nomenclature authority: forkhead box O1
NCBI GeneID: 2308
gene map location: 13q14.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 13
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001078 (EC: IEA); GO_0001568 (EC: IBA); GO_0001659 (EC: ISS); GO_0001678 (EC: ISS); GO_0003682 (EC: ISS); GO_0005515 (EC: IPI, PMID: 11237865); GO_0005634 (EC: IDA, PMID: 11311120); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA, PMID: 11237865); GO_0005739 (EC: ISS); GO_0005829 (EC: ISS); GO_0005829 (EC: TAS); GO_0006473 (EC: ISS); GO_0006915 (EC: IEA); GO_0006974 (EC: ISS); GO_0007173 (EC: TAS); GO_0007389 (EC: IBA); GO_0008286 (EC: ISS); GO_0008301 (EC: IBA); GO_0008543 (EC: TAS); GO_0009267 (EC: ISS); GO_0009790 (EC: IBA); GO_0009888 (EC: IBA); GO_0031018 (EC: TAS); GO_0032873 (EC: IDA, PMID: 19696738); GO_0034599 (EC: ISS); GO_0035947 (EC: IEA); GO_0038095 (EC: TAS); GO_0042127 (EC: IEA); GO_0043066 (EC: IDA, PMID: 10871843); GO_0043565 (EC: IDA, PMID: 12228231); GO_0045087 (EC: TAS); GO_0045444 (EC: ISS); GO_0045599 (EC: ISS); GO_0045722 (EC: IEA); GO_0045892 (EC: ISS); GO_0045893 (EC: IDA, PMID: 10871843); GO_0045944 (EC: IDA, PMID: 10871843); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0051721 (EC: ISS); GO_0070417 (EC: ISS); GO_0071732 (EC: ISS); GO_2000505 (EC: ISS)
has PubMed association: PMID: 7630639; 7862145; 8275086; 8634710; 8790412; 9479491; 10358014; 10358075; 10783894; 10871843; 10973497; 11030146; 11237865; 11311120; 11353774; 11435445; 11672436; 11735247; 11893744; 11980723; 12039929; 12150827; 12163409; 12228231; 12242297; 12477932; 12482965; 12493691; 12519792; 12560069; 12606503; 12921955; 12960271; 12966085; 13679577; 14664696; 14726521; 15047604; 15057823; 15084259; 15109499; 15140004; 15184910; 15220471; 15342912; 15489334; 15582274; 15613482; 15632117; 15668399; 15688035; 15688409; 15692560; 15778376; 15890677; 15905404; 15987820; 16076959; 16100571; 16123151; 16133873; 16154098; 16282329; 16485043; 16492665; 16497530; 16571842; 16670089; 16690806; 16709600; 16849544; 16885156; 16916907; 16943287; 16950602; 16952014; 16952980; 16964289; 16973122; 16979636; 17030088; 17038621; 17050673; 17077083; 17202144; 17210752; 17218607; 17258205; 17285543; 17404186; 17442120; 17478621; 17490646; 17491598; 17525748; 17555999; 17556536; 17597184; 17599040; 17609436; 17613043; 17638879; 17873969; 17986608; 17993506; 18006475; 18022385; 18029348; 18096667; 18280254; 18301748; 18303411; 18316359; 18356527; 18408765; 18420577; 18483260; 18497882; 18497885; 18612045; 18660489; 18692812; 18713968; 18718910; 18786403; 18787186; 18788887; 18805788; 18815134; 18844239; 18951090; 18988640; 19049975; 19058789; 19075016; 19086408; 19103600; 19141580; 19150739; 19221179; 19233123; 19244250; 19254690; 19281796; 19293131; 19308286; 19321440; 19442434; 19463968; 19483080; 19503105; 19513505; 19535741; 19549905; 19563779; 19574223; 19584310; 19633686; 19675556; 19686743; 19696738; 19727442; 19740748; 19757185; 19772960; 19787258; 19793722; 19887561; 19893043; 19948975; 19953635; 19956688; 20018872; 20033803; 20061393; 20095040; 20125105; 20151947; 20351326; 20353756; 20357092; 20406953; 20412774; 20485516; 20543840; 20682687; 20719862; 20819778; 20868688; 20874444; 20884733; 20933505; 21069157; 21075101; 21116854; 21177767; 21177856; 21179458; 21185807; 21238503; …
description: forkhead box O1
database cross reference: Ensembl:ENSG00000150907
database cross reference: HGNC:3819
database cross reference: HPRD:00645
database cross reference: MIM:136533
database cross reference: Vega:OTTHUMG00000016775

FMR1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FMRP
alternative term: FRAXA
alternative term: POF
alternative term: POF1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: FMR1
full name from nomenclature authority: fragile X mental retardation 1
NCBI GeneID: 2332
gene map location: Xq27.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003723 (EC: TAS, PMID: 8156595); GO_0003729 (EC: TAS, PMID: 7692601); GO_0005515 (EC: IPI, PMID: 10556305); GO_0005654 (EC: TAS, PMID: 10888599); GO_0005730 (EC: TAS, PMID: 16407062); GO_0005737 (EC: IDA); GO_0005737 (EC: TAS, PMID: 16407062); GO_0005845 (EC: ISS); GO_0007417 (EC: IEA); GO_0010494 (EC: IEA); GO_0042788 (EC: TAS, Qualifier: colocalizes_with, PMID: 12837692); GO_0043197 (EC: IEA); GO_0043198 (EC: IEA); GO_0044822 (EC: IDA); GO_0045202 (EC: IEA); GO_0045947 (EC: ISS); GO_0051028 (EC: IEA); GO_0071598 (EC: IEA)
has PubMed association: PMID: 1572655; 1710175; 1757956; 1913811; 2988332; 7141005; 7489725; 7633450; 7670500; 7688265; 7692601; 7781595; 7825604; 8069329; 8095365; 8156595; 8348153; 8358432; 8401496; 8401531; 8401578; 8490650; 8504300; 8515814; 8528261; 8668200; 8789445; 9302998; 9375856; 9497258; 9659908; 9829913; 10398250; 10527928; 10556305; 10567518; 10729312; 10888599; 11119302; 11129329; 11142760; 11142761; 11162447; 11256870; 11367701; 11415517; 11438699; 11443541; 11445641; 11545690; 11840495; 11854169; 11897823; 11992259; 12107447; 12112763; 12116230; 12116303; 12147688; 12210320; 12232854; 12378270; 12388589; 12417734; 12477932; 12515381; 12529854; 12594214; 12596051; 12745094; 12810982; 12837692; 12927206; 12950170; 14570712; 14599277; 14746957; 14747503; 14755444; 14993603; 15000256; 15065016; 15096575; 15121898; 15146197; 15175277; 15282548; 15300658; 15303970; 15377638; 15381024; 15381419; 15483045; 15483640; 15563507; 15608041; 15617547; 15629215; 15642922; 15659577; 15696166; 15741991; 15742217; 15805463; 15861180; 15879417; 15929093; 15930016; 15950084; 15956167; 15971024; 16006558; 16049924; 16055059; 16078053; 16117724; 16161415; 16184602; 16271017; 16319129; 16337617; 16361284; 16407062; 16456258; 16500716; 16500891; 16508954; 16636078; 16708166; 16793928; 16819831; 16891414; 16905681; 16907702; 17044853; 17097142; 17101793; 17179750; 17196195; 17283214; 17290448; 17506288; 17548778; 17588953; 17620491; 17674408; 17714511; 17850748; 17881655; 17917121; 17922850; 17932962; 17962727; 17966892; 17978095; 18057083; 18057320; 18074381; 18093976; 18163424; 18165971; 18172867; 18181681; 18211155; 18225979; 18273822; 18310361; 18310677; 18323308; 18357616; 18373410; 18384775; 18384784; 18403614; 18412117; 18413472; 18427356; 18471319; 18472033; 18487560; 18535897; 18553360; 18565783; 18570292; 18583885; 18628788; 18630123; 18632687; 18656952; 18664458; 18687789; 18789568; 18922172; 18973899; 19005212; 19026394; 19041959; 19056494; 19097999; 19105204; 19116286; 19147914; 191553…
description: fragile X mental retardation 1
database cross reference: Ensembl:ENSG00000102081
database cross reference: HGNC:3775
database cross reference: HPRD:02398
database cross reference: MIM:309550
database cross reference: Vega:OTTHUMG00000022606

FNTA
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FPTA
alternative term: PGGT1A
alternative term: PTAR2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: FNTA
full name from nomenclature authority: farnesyltransferase, CAAX box, alpha
NCBI GeneID: 2339
gene map location: 8p11
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004660 (EC: IDA, PMID: 16893176); GO_0004660 (EC: IDA, Qualifier: contributes_to, PMID: 19228685); GO_0004661 (EC: IDA, PMID: 16893176); GO_0004662 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11687658); GO_0005737 (EC: TAS, PMID: 8599089); GO_0005829 (EC: TAS); GO_0005875 (EC: IDA, PMID: 19228685); GO_0005953 (EC: IDA, PMID: 16893176); GO_0005965 (EC: IDA, PMID: 16893176); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0007179 (EC: TAS, PMID: 8599089); GO_0007603 (EC: TAS); GO_0008017 (EC: IDA, PMID: 19228685); GO_0016056 (EC: TAS); GO_0018343 (EC: IDA, PMID: 16893176); GO_0018344 (EC: IDA, PMID: 16893176); GO_0022400 (EC: TAS); GO_0043014 (EC: IDA, PMID: 19228685); GO_0090044 (EC: IDA, PMID: 19228685); GO_0090045 (EC: IDA, PMID: 19228685)
has PubMed association: PMID: 1400319; 2217184; 7713879; 8106351; 8175923; 8276393; 8419339; 8494894; 8530343; 8599089; 8830800; 8889548; 8910345; 10676968; 10747914; 10852915; 11313965; 11598000; 11687658; 12036349; 12374986; 12477932; 12825937; 14702039; 15170324; 15451670; 15489334; 16893176; 17192483; 17353931; 18187620; 18406652; 18654987; 19228685; 19841875; 20403997; 21139048; 21906983; 21988832; 22160308; 22863883; 23602568
description: farnesyltransferase, CAAX box, alpha
database cross reference: Ensembl:ENSG00000168522
database cross reference: HGNC:3782
database cross reference: HPRD:00607
database cross reference: MIM:134635
database cross reference: Vega:OTTHUMG00000165279

MTOR
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FRAP
alternative term: FRAP1
alternative term: FRAP2
alternative term: RAFT1
alternative term: RAPT1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MTOR
full name from nomenclature authority: mechanistic target of rapamycin (serine/threonine kinase)
NCBI GeneID: 2475
gene map location: 1p36.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: IEA); GO_0001030 (EC: IDA); GO_0001031 (EC: IDA); GO_0001032 (EC: IDA); GO_0001156 (EC: IDA); GO_0001934 (EC: IDA); GO_0001938 (EC: IEA); GO_0004674 (EC: IDA, PMID: 15467718); GO_0004674 (EC: TAS); GO_0005515 (EC: IPI, PMID: 10089303); GO_0005524 (EC: IEA); GO_0005737 (EC: IDA, PMID: 11853878); GO_0005741 (EC: IEA); GO_0005764 (EC: IDA); GO_0005765 (EC: IDA, PMID: 17897319); GO_0005789 (EC: IEA); GO_0005829 (EC: TAS); GO_0005942 (EC: NAS, PMID: 15539461); GO_0005979 (EC: IEA); GO_0006468 (EC: IDA, PMID: 15467718); GO_0006468 (EC: IMP, PMID: 17028174); GO_0006950 (EC: IMP, PMID: 17028174); GO_0007165 (EC: NAS, PMID: 15539461); GO_0007173 (EC: TAS); GO_0007281 (EC: IEA); GO_0007584 (EC: NAS, PMID: 15539461); GO_0008144 (EC: IEA); GO_0008286 (EC: TAS); GO_0008543 (EC: TAS); GO_0010507 (EC: ISS); GO_0010592 (EC: IEA); GO_0010628 (EC: IMP, PMID: 17028174); GO_0010831 (EC: IEA); GO_0012505 (EC: IDA, PMID: 18497260); GO_0016020 (EC: IDA, PMID: 11853878); GO_0016049 (EC: IDA, PMID: 18762023); GO_0016049 (EC: TAS, PMID: 11853878); GO_0016242 (EC: IEA); GO_0016301 (EC: IDA, PMID: 15467718); GO_0016301 (EC: TAS, PMID: 11853878); GO_0016310 (EC: IDA, PMID: 11853878); GO_0016605 (EC: ISS, Qualifier: colocalizes_with); GO_0018105 (EC: IMP); GO_0018107 (EC: IEA); GO_0019904 (EC: IEA); GO_0030163 (EC: TAS, PMID: 11853878); GO_0030838 (EC: IEA); GO_0031295 (EC: TAS); GO_0031529 (EC: IEA); GO_0031669 (EC: ISS); GO_0031929 (EC: IMP, PMID: 15467718); GO_0031931 (EC: IDA, PMID: 15467718); GO_0031931 (EC: IMP); GO_0031932 (EC: IDA, PMID: 15467718); GO_0031998 (EC: IEA); GO_0032095 (EC: IEA); GO_0032314 (EC: IEA); GO_0032956 (EC: IMP, PMID: 15467718); GO_0038095 (EC: TAS); GO_0040007 (EC: NAS, PMID: 15539461); GO_0043022 (EC: IEA); GO_0043200 (EC: IDA, PMID: 18497260); GO_0043610 (EC: IEA); GO_0045087 (EC: TAS); GO_0045727 (EC: IDA, PMID: 18762023); GO_0045792 (EC: IEA); GO_0045859 (EC: IEA); GO_0045945 (EC: IMP); GO_0046777 (EC: IDA, PMID: 15467718); GO_0046889 (EC: IMP, …
has PubMed association: PMID: 7539137; 7809080; 7822316; 8008069; 8083223; 8660990; 8662507; 9092573; 9099849; 9405468; 9434772; 9465032; 9653645; 10089303; 10200280; 10325225; 10364159; 10567431; 10660304; 10664457; 10698949; 10702316; 10753870; 10779345; 10910062; 10942774; 10971657; 11114166; 11279232; 11287630; 11426320; 11438723; 11602639; 11691836; 11691993; 11729323; 11733037; 11777913; 11853878; 11884412; 11914378; 11930000; 11967149; 12000755; 12030785; 12080086; 12105188; 12145207; 12150925; 12150926; 12172553; 12231510; 12242281; 12271141; 12370290; 12408816; 12477932; 12558800; 12604610; 12665511; 12718876; 12719976; 12747827; 12796477; 12807916; 12813467; 12820960; 12912989; 14578359; 14668532; 14679009; 14729629; 14970221; 15001544; 15004009; 15028555; 15056668; 15066126; 15150271; 15161933; 15218033; 15268862; 15284440; 15292274; 15317677; 15342556; 15388791; 15452223; 15459249; 15467718; 15489334; 15489897; 15496972; 15522880; 15539461; 15576463; 15580312; 15584862; 15604215; 15605414; 15623621; 15624760; 15632115; 15632201; 15657358; 15659381; 15702344; 15708965; 15718470; 15723049; 15755954; 15767663; 15772076; 15796538; 15802268; 15809305; 15843522; 15854902; 15878852; 15896331; 15899889; 15905173; 15953364; 16006564; 16027121; 16049009; 16098202; 16098514; 16099944; 16109716; 16141350; 16183647; 16221682; 16242075; 16282343; 16286006; 16341243; 16354680; 16407298; 16427044; 16452250; 16467080; 16541103; 16543150; 16603397; 16631613; 16652388; 16710414; 16786123; 16798736; 16818690; 16824195; 16837165; 16847060; 16849522; 16870609; 16874098; 16884363; 16912159; 16912980; 16914728; 16915281; 16916907; 16919458; 16922504; 16927414; 16929481; 16954686; 16959214; 16962653; 16963469; 17016437; 17018601; 17028174; 17043309; 17052453; 17075574; 17102641; 17110454; 17114181; 17148679; 17215282; 17253963; 17277771; 17289850; 17318075; 17329400; 17329620; 17351147; 17360675; 17363738; 17372934; 17386266; 17409838; 17461779; 17463046; 17470430; 17482291; 17483438; 17488873; 1754551…
description: mechanistic target of rapamycin (serine/threonine kinase)
database cross reference: Ensembl:ENSG00000198793
database cross reference: HGNC:3942
database cross reference: HPRD:03134
database cross reference: MIM:601231
database cross reference: Vega:OTTHUMG00000002001

FTL
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LFTD
alternative term: NBIA3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: FTL
full name from nomenclature authority: ferritin, light polypeptide
NCBI GeneID: 2512
gene map location: 19q13.33
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005506 (EC: IDA, PMID: 19923220); GO_0005515 (EC: IPI, PMID: 16169070); GO_0005829 (EC: TAS); GO_0006826 (EC: IEA); GO_0006879 (EC: TAS); GO_0006892 (EC: TAS); GO_0008043 (EC: IDA, PMID: 19923220); GO_0008199 (EC: IEA); GO_0008219 (EC: IEA); GO_0042802 (EC: IPI, PMID: 16169070); GO_0055072 (EC: TAS, PMID: 19923220); GO_0055085 (EC: TAS); GO_0061024 (EC: TAS); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 659425; 2821803; 3000916; 3023856; 3291676; 3754330; 3840162; 3857215; 3858810; 6572903; 6653779; 7492760; 7493028; 7575610; 8041631; 8554925; 8630420; 8636399; 8706699; 8781450; 8864140; 9119260; 9169099; 9196065; 9226182; 9292547; 9414300; 9414313; 9457670; 9526618; 10491119; 10753629; 10759702; 10828006; 11031247; 11252894; 11438811; 11591653; 11783942; 11849230; 12071855; 12199804; 12200611; 12387819; 12401807; 12459518; 12477932; 12646258; 12746423; 14615048; 15099026; 15231747; 15231748; 15390032; 15489334; 15727900; 15835264; 16116125; 16169070; 16189514; 16217041; 16222695; 16252260; 16289162; 16790936; 16822677; 16858508; 17116749; 17459943; 17601350; 17660802; 17761032; 17970701; 18061976; 18160403; 18413574; 18486613; 18586377; 18621011; 18624398; 18665827; 18755684; 18977241; 19056867; 19176363; 19254706; 19318681; 19519778; 19781644; 19787796; 19910193; 19923220; 20088381; 20159981; 20301320; 20345975; 20381070; 20471030; 20689807; 21029774; 21103663; 21139048; 21139976; 21541272; 21555518; 21696736; 21800051; 21906983; 21907119; 22020773; 22117997; 22248276; 22348978; 22359459; 22535864; 22760008; 22863883; 22939629; 23029420; 23080069; 23119080; 23275563; 23300545; 23381919; 23421845; 23463506; 23592921; 23685131; 23699174
description: ferritin, light polypeptide
database cross reference: Ensembl:ENSG00000087086
database cross reference: HGNC:3999
database cross reference: HPRD:00616
database cross reference: MIM:134790
database cross reference: Vega:OTTHUMG00000183332

FYN
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SLK
alternative term: SYN
alternative term: p59-FYN
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: FYN
full name from nomenclature authority: FYN oncogene related to SRC, FGR, YES
NCBI GeneID: 2534
NCBI LocusTag: RP1-66H14.1
gene map location: 6q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001764 (EC: IEA); GO_0001948 (EC: IPI, PMID: 16831868); GO_0004713 (EC: EXP); GO_0004713 (EC: TAS); GO_0004715 (EC: NAS, PMID: 7822789); GO_0005515 (EC: IPI, PMID: 10209036); GO_0005524 (EC: IEA); GO_0005634 (EC: IEA); GO_0005739 (EC: IEA); GO_0005768 (EC: IDA, PMID: 15611048); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 12150984); GO_0006468 (EC: NAS, PMID: 7822789); GO_0006816 (EC: NAS, PMID: 7822789); GO_0007173 (EC: TAS); GO_0007411 (EC: TAS); GO_0007596 (EC: TAS); GO_0007612 (EC: TAS, PMID: 1361685); GO_0007631 (EC: TAS, PMID: 8264796); GO_0008360 (EC: IEA); GO_0008543 (EC: TAS); GO_0010629 (EC: IEA); GO_0010976 (EC: IEA); GO_0014069 (EC: IEA); GO_0015631 (EC: IEA); GO_0016032 (EC: TAS); GO_0030168 (EC: TAS); GO_0030900 (EC: IEA); GO_0031295 (EC: TAS); GO_0035556 (EC: TAS, PMID: 1361685); GO_0038095 (EC: TAS); GO_0038096 (EC: TAS); GO_0042177 (EC: IEA); GO_0042493 (EC: IEA); GO_0042608 (EC: IEA); GO_0042609 (EC: IEA); GO_0042610 (EC: IEA); GO_0043548 (EC: IEA); GO_0044325 (EC: IEA); GO_0045087 (EC: TAS); GO_0045121 (EC: IDA, Qualifier: colocalizes_with, PMID: 12150984); GO_0045471 (EC: IEA); GO_0046777 (EC: IEA); GO_0046872 (EC: IEA); GO_0046875 (EC: IPI, PMID: 10498895); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0048813 (EC: IEA); GO_0050690 (EC: TAS); GO_0050798 (EC: IEA); GO_0050852 (EC: IDA, PMID: 7722293); GO_0050900 (EC: TAS); GO_0050966 (EC: IEA); GO_0051428 (EC: IEA); GO_0070851 (EC: IPI, PMID: 16479011); GO_0071375 (EC: IEA); GO_1900182 (EC: IEA); GO_2001240 (EC: IEA)
has PubMed association: PMID: 82; 119942; 1334406; 1351058; 1361685; 1384720; 1385527; 1387715; 1446976; 1454062; 1530920; 1544885; 1696179; 1699196; 1715582; 1717997; 1985196; 3099169; 3330788; 3526330; 7504057; 7515933; 7516469; 7517401; 7521304; 7525550; 7537495; 7545683; 7565724; 7588629; 7589084; 7589101; 7589480; 7595520; 7642581; 7664083; 7681396; 7682059; 7687536; 7722293; 7760813; 7782294; 7822789; 7859737; 7929439; 8058772; 8104794; 8262983; 8264796; 8294442; 8394019; 8395016; 8483935; 8493579; 8566014; 8621384; 8621719; 8626376; 8626543; 8631859; 8655574; 8662998; 8671590; 8681387; 8756631; 8760790; 8798684; 8805332; 8805554; 8810341; 8883579; 8900205; 8910336; 8961927; 8980254; 8995358; 8995379; 9028946; 9032261; 9038134; 9043947; 9045636; 9047237; 9060467; 9079653; 9091579; 9104812; 9118959; 9121430; 9169421; 9185665; 9188452; 9195899; 9195918; 9196040; 9207119; 9230816; 9252391; 9269777; 9295288; 9311917; 9344703; 9344857; 9351806; 9351809; 9360983; 9366405; 9368621; 9417082; 9425276; 9446569; 9507006; 9531288; 9535845; 9535867; 9553134; 9573028; 9576921; 9603925; 9632142; 9648856; 9670010; 9674711; 9677430; 9687533; 9710204; 9712716; 9741627; 9748251; 9750131; 9756930; 9763511; 9778343; 9799234; 9804857; 9819391; 9822663; 9837776; 9837978; 9846481; 9856337; 9890970; 9892651; 9973379; 10022833; 10089404; 10092522; 10196263; 10209036; 10212213; 10224664; 10229084; 10339567; 10383400; 10435619; 10447714; 10458595; 10482988; 10498895; 10532312; 10544125; 10551884; 10564280; 10570256; 10571044; 10571082; 10586033; 10591186; 10629042; 10636929; 10642173; 10708762; 10733577; 10739664; 10744724; 10764799; 10790433; 10799548; 10804218; 10816433; 10829062; 10858437; 10867021; 10871840; 10872802; 10896916; 10921922; 10945997; 11005864; 11024032; 11075717; 11078745; 11087735; 11121167; 11149959; 11157475; 11158295; 11162638; 11204284; 11239464; 11262396; 11278378; 11278857; 11298344; 11353545; 11356869; 11423543; 11466305; 11483358; 11483655; 11526103; 11536198; 11546790; 11594778; 1159…
description: FYN oncogene related to SRC, FGR, YES
database cross reference: Ensembl:ENSG00000010810
database cross reference: HGNC:4037
database cross reference: HPRD:00655
database cross reference: MIM:137025
database cross reference: Vega:OTTHUMG00000016305

GALR1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GALNR
alternative term: GALNR1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GALR1
full name from nomenclature authority: galanin receptor 1
NCBI GeneID: 2587
gene map location: 18q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 18
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004966 (EC: IEA); GO_0005515 (EC: IPI); GO_0005886 (EC: TAS); GO_0007189 (EC: IEA); GO_0007194 (EC: IEA); GO_0007204 (EC: IEA); GO_0007218 (EC: TAS, PMID: 7524088); GO_0007586 (EC: TAS, PMID: 8670213); GO_0016021 (EC: IEA); GO_0042923 (EC: IEA)
has PubMed association: PMID: 2834384; 7524088; 7534460; 8617199; 8670213; 8825658; 9168941; 9367674; 9425310; 9808667; 12477932; 15767248; 15930442; 17083333; 17982695; 18385373; 18577758; 18973137; 19047085; 19086053; 19913121; 20171159; 20201926; 20398908; 20468064; 20628086; 21430647; 21796100; 22859720; 23251661; 23727823
description: galanin receptor 1
database cross reference: HGNC:4132
database cross reference: HPRD:02657
database cross reference: MIM:600377

GAPDH
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: G3PD
alternative term: GAPD
alternative term: HEL-S-162eP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GAPDH
full name from nomenclature authority: glyceraldehyde-3-phosphate dehydrogenase
NCBI GeneID: 2597
NCBI LocusTag: CDABP0047
gene map location: 12p13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000226 (EC: ISS); GO_0004365 (EC: ISS); GO_0004365 (EC: NAS, PMID: 3170585); GO_0005515 (EC: IPI, PMID: 11724794); GO_0005634 (EC: ISS); GO_0005737 (EC: IDA); GO_0005737 (EC: ISS); GO_0005811 (EC: IDA, PMID: 14741744); GO_0005829 (EC: ISS); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA); GO_0005975 (EC: TAS); GO_0006006 (EC: TAS); GO_0006094 (EC: TAS); GO_0006096 (EC: IEA); GO_0006096 (EC: TAS); GO_0008017 (EC: ISS); GO_0015630 (EC: ISS); GO_0017148 (EC: IDA); GO_0017148 (EC: IMP, PMID: 15479637); GO_0030529 (EC: IDA, PMID: 15479637); GO_0035605 (EC: ISS); GO_0035606 (EC: ISS); GO_0042802 (EC: IPI); GO_0044281 (EC: TAS); GO_0048471 (EC: IEA); GO_0050661 (EC: IEA); GO_0050821 (EC: ISS); GO_0051287 (EC: IEA); GO_0051402 (EC: ISS); GO_0070062 (EC: IDA, PMID: 11487543); GO_0071346 (EC: IDA, PMID: 15479637); GO_0097452 (EC: IDA, PMID: 15479637)
has PubMed association: PMID: 957435; 1193541; 1602151; 1924305; 1999197; 2394733; 2793178; 2987855; 3027061; 3170585; 3180054; 3664468; 6095107; 6096136; 6096821; 6499844; 7030790; 7498159; 7880402; 8075252; 8181459; 8451199; 8473906; 8612237; 8619474; 8650074; 8872471; 9110174; 9308888; 9886087; 10097256; 10407144; 10617673; 10897012; 10944468; 11011077; 11157717; 11451542; 11487543; 11488911; 11724794; 11735259; 11846445; 12008025; 12087577; 12121569; 12140138; 12200519; 12381782; 12419855; 12428732; 12477932; 12503091; 12506084; 12553051; 12665801; 12697324; 12753082; 12829261; 12842090; 12842822; 12887926; 12921788; 14515148; 14630908; 14730345; 14741744; 14760703; 15001839; 15047060; 15107835; 15161933; 15199064; 15312048; 15383276; 15479637; 15485821; 15489334; 15507493; 15592455; 15604093; 15628863; 15635413; 15673432; 15680915; 15716040; 15746184; 15769908; 15839736; 15852347; 15907785; 15951807; 15952740; 15976103; 15985219; 16027165; 16037232; 16055720; 16082386; 16139273; 16169070; 16186172; 16196087; 16236267; 16239728; 16263121; 16289162; 16396496; 16474839; 16492755; 16501887; 16510976; 16515701; 16682416; 16713569; 16751257; 16778134; 16799092; 16815975; 16832079; 16892178; 17015754; 17027006; 17081983; 17121833; 17324518; 17353931; 17373842; 17387692; 17456004; 17540579; 17540725; 17553795; 17597534; 17620599; 17955473; 17989880; 18029348; 18163542; 18206965; 18340469; 18362144; 18364388; 18448829; 18552833; 18624398; 18682386; 18708368; 18776186; 18776667; 18781797; 19001379; 19135240; 19156129; 19161537; 19165527; 19338310; 19380743; 19405953; 19430704; 19464723; 19596686; 19605696; 19621076; 19650766; 19738201; 19747091; 19800890; 19805454; 19837666; 19874799; 19940145; 20177150; 20181627; 20381070; 20407807; 20471030; 20610654; 20639865; 20664973; 20707929; 20727968; 20800603; 20849852; 20864222; 20972425; 21044950; 21073742; 21080425; 21110914; 21139048; 21145461; 21151833; 21163940; 21182205; 21236242; 21319273; 21336310; 21338575; 21539808; 21565611; 21749859; 21832…
description: glyceraldehyde-3-phosphate dehydrogenase
database cross reference: Ensembl:ENSG00000111640
database cross reference: HGNC:4141
database cross reference: HPRD:00713
database cross reference: MIM:138400
database cross reference: Vega:OTTHUMG00000137379

GAS1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GAS1
full name from nomenclature authority: growth arrest-specific 1
NCBI GeneID: 2619
gene map location: 9q21.3-q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002053 (EC: IEA); GO_0005515 (EC: IPI); GO_0005886 (EC: IDA, PMID: 8127893); GO_0007050 (EC: IEA); GO_0007411 (EC: IEA); GO_0008589 (EC: ISS); GO_0010955 (EC: IMP); GO_0012501 (EC: IEA); GO_0016021 (EC: NAS, PMID: 8127893); GO_0021587 (EC: IEA); GO_0021904 (EC: IEA); GO_0030308 (EC: IEA); GO_0035924 (EC: IEP, PMID: 15070677); GO_0042473 (EC: IEA); GO_0042474 (EC: IEA); GO_0042476 (EC: IEA); GO_0042733 (EC: IEA); GO_0042981 (EC: ISS); GO_0043010 (EC: IEA); GO_0043066 (EC: IEA); GO_0045165 (EC: ISS); GO_0045879 (EC: IEA); GO_0045880 (EC: IEA); GO_0045930 (EC: IDA, PMID: 8127893); GO_0045930 (EC: IGI, PMID: 11356029); GO_0046658 (EC: ISS); GO_0048589 (EC: ISS); GO_0048592 (EC: IEA); GO_0048701 (EC: IEA); GO_0050679 (EC: IEA); GO_0050680 (EC: IEA); GO_0060021 (EC: IEA); GO_0060628 (EC: IMP); GO_2001240 (EC: IEA)
has PubMed association: PMID: 1505026; 7956349; 8127893; 8307588; 8889548; 9466658; 10996315; 11356029; 11572986; 11846389; 11906213; 12477932; 15070677; 15103018; 16551639; 17726382; 18394855; 18981472; 19322201; 19460624; 19638344; 20050020; 20583177; 20628624; 21111449; 21357679; 21842183; 21890473; 21901158; 21971401; 22311470; 22846196; 23254899
description: growth arrest-specific 1

GDI1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: 1A
alternative term: GDIL
alternative term: MRX41
alternative term: MRX48
alternative term: OPHN2
alternative term: RABGD1A
alternative term: RABGDIA
alternative term: XAP-4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GDI1
full name from nomenclature authority: GDP dissociation inhibitor 1
NCBI GeneID: 2664
NCBI LocusTag: XX-FW81657B9.1
gene map location: Xq28
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005092 (EC: TAS, PMID: 7849400); GO_0005093 (EC: ISS); GO_0005096 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11809807); GO_0005737 (EC: IDA); GO_0005794 (EC: IEA); GO_0005829 (EC: TAS); GO_0007165 (EC: TAS, PMID: 7543319); GO_0007264 (EC: TAS); GO_0015031 (EC: IEA); GO_0017137 (EC: IEA); GO_0030496 (EC: IDA, PMID: 15166316); GO_0032482 (EC: ISS); GO_0043005 (EC: IEA); GO_0043234 (EC: IEA); GO_0050771 (EC: ISS); GO_0050790 (EC: ISS); GO_0050790 (EC: TAS, PMID: 7849400); GO_0051056 (EC: TAS); GO_0051592 (EC: IEA); GO_0090315 (EC: IMP)
has PubMed association: PMID: 1286667; 2115118; 7513052; 7543319; 7585614; 7744738; 7849400; 8175798; 8248200; 8281148; 8491184; 8733135; 8826463; 8836150; 9106537; 9490022; 9620768; 9668174; 9674910; 10751420; 11076863; 11256614; 11583574; 11741295; 11809807; 12198156; 12477932; 12777533; 12802062; 14702039; 15166316; 15292224; 15480879; 15489334; 15489336; 15592455; 15647276; 16344560; 16368544; 16381901; 16596196; 16713569; 17353931; 17568003; 18255255; 18487148; 19570034; 19996123; 20381070; 20562859; 21139048; 21145461; 21319273; 21565611; 21736009; 21890473; 21900206; 21906983; 21963094; 21987572; 22002931; 22053931; 22114354; 22505724; 22586326; 22863883; 22939629; 23000965; 23140504
description: GDP dissociation inhibitor 1
database cross reference: Ensembl:ENSG00000203879
database cross reference: HGNC:4226
database cross reference: HPRD:02114
database cross reference: MIM:300104
database cross reference: Vega:OTTHUMG00000033293

GDI2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HEL-S-46e
alternative term: RABGDIB
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GDI2
full name from nomenclature authority: GDP dissociation inhibitor 2
NCBI GeneID: 2665
NCBI LocusTag: RP11-318E3.2
gene map location: 10p15
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005093 (EC: IEA); GO_0005097 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11809807); GO_0005737 (EC: TAS, PMID: 16130169); GO_0005794 (EC: IEA); GO_0005829 (EC: TAS); GO_0007165 (EC: TAS, PMID: 16130169); GO_0007264 (EC: TAS); GO_0015031 (EC: IEA); GO_0016020 (EC: IEA); GO_0044822 (EC: IDA); GO_0051056 (EC: TAS); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 7513052; 7543319; 7585614; 7929030; 8575461; 9434952; 10512627; 10996854; 11771757; 11809807; 12477932; 12493773; 14702039; 15489334; 16009940; 16130169; 16344560; 16385451; 17507299; 18781797; 19056867; 19135240; 19322201; 19570034; 19738201; 20360068; 20562859; 21139048; 21565611; 21890473; 21906983; 21963094; 21987572; 21988832; 22053931; 22505724; 22586326; 22863883; 22939629; 23000965; 23184937; 23727862; 23824909
description: GDP dissociation inhibitor 2
database cross reference: Ensembl:ENSG00000057608
database cross reference: HGNC:4227
database cross reference: HPRD:02863
database cross reference: MIM:600767
database cross reference: Vega:OTTHUMG00000017607

GFAP
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GFAP
full name from nomenclature authority: glial fibrillary acidic protein
NCBI GeneID: 2670
gene map location: 17q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005178 (EC: IEA); GO_0005200 (EC: IEA); GO_0005737 (EC: IDA, PMID: 12355421); GO_0005829 (EC: TAS); GO_0005882 (EC: IEA); GO_0009611 (EC: IEA); GO_0010625 (EC: IEA); GO_0010977 (EC: IEA); GO_0014002 (EC: IEA); GO_0016020 (EC: IEA); GO_0019900 (EC: IEA); GO_0030198 (EC: IEA); GO_0031102 (EC: IEA); GO_0044297 (EC: IEA); GO_0045109 (EC: IEA); GO_0051580 (EC: IEA); GO_0060020 (EC: IEA); GO_0060291 (EC: IEA); GO_0097449 (EC: IEA)
has PubMed association: PMID: 1601131; 1602151; 1636374; 1847665; 1918004; 2114109; 2155236; 2163003; 2201025; 2349237; 2740350; 2780570; 7822264; 7842474; 7964717; 8125298; 8318270; 8381971; 8889548; 9099667; 9417904; 9693047; 10510252; 10597774; 11138011; 11379820; 11519482; 11567214; 11587071; 11595337; 11867077; 11891800; 12034796; 12058025; 12084347; 12169273; 12177195; 12355421; 12447932; 12477932; 12581808; 12686604; 12771190; 12837269; 12884016; 12931206; 12944715; 12975300; 14557587; 14702039; 15174051; 15238995; 15284230; 15285794; 15465095; 15469203; 15477559; 15489334; 15519244; 15732097; 15837555; 15839736; 15885920; 15979880; 16147953; 16168593; 16168595; 16189514; 16217707; 16303762; 16344560; 16365790; 16458536; 16507904; 16507909; 16565071; 16773221; 16826512; 16866629; 17008879; 17077296; 17203480; 17318298; 17500595; 17515952; 17590381; 17601350; 17703343; 17805552; 17894839; 17934883; 17981838; 17985264; 18004641; 18054694; 18079314; 18197187; 18239623; 18276609; 18508349; 18685083; 18977241; 19019082; 19034380; 19110265; 19129171; 19170683; 19221847; 19264642; 19283393; 19372295; 19379794; 19405953; 19420941; 19427371; 19444543; 19447584; 19508443; 19521276; 19540848; 19618846; 19647039; 19663312; 19668151; 19686046; 19878567; 19886840; 19888461; 20048155; 20121722; 20301351; 20471030; 20473970; 20578042; 20625342; 20721574; 20849398; 20886841; 20936779; 20942581; 21075782; 21079180; 21197541; 21368691; 21702960; 21756903; 21779366; 21832049; 21876753; 21917775; 21976236; 21987397; 21988832; 22118268; 22206859; 22318658; 22360420; 22410258; 22488673; 22492246; 22797925; 22985558; 23321059; 23364391; 23371454; 23392373; 23418544; 23455922; 23594359; 23624779; 23626774; 23634874; 23743246; 23746601; 23826164; 23827424; 23903069; 24045243
description: glial fibrillary acidic protein

GFPT1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CMSTA1
alternative term: GFA
alternative term: GFAT
alternative term: GFAT 1
alternative term: GFAT1
alternative term: GFAT1m
alternative term: GFPT
alternative term: GFPT1L
alternative term: MSLG
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GFPT1
full name from nomenclature authority: glutamine--fructose-6-phosphate transaminase 1
NCBI GeneID: 2673
gene map location: 2p13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004360 (EC: IEA); GO_0005829 (EC: TAS); GO_0006002 (EC: IEA); GO_0006042 (EC: IEA); GO_0006048 (EC: IEA); GO_0006048 (EC: TAS); GO_0006112 (EC: TAS, PMID: 1460020); GO_0006488 (EC: TAS); GO_0006541 (EC: IEA); GO_0006987 (EC: TAS); GO_0009744 (EC: IEA); GO_0016051 (EC: IEA); GO_0016597 (EC: IEA); GO_0018279 (EC: TAS); GO_0030246 (EC: IEA); GO_0030968 (EC: TAS); GO_0032869 (EC: IEA); GO_0032922 (EC: ISS); GO_0043687 (EC: TAS); GO_0044267 (EC: TAS); GO_0045719 (EC: IEA); GO_0051289 (EC: IEA); GO_0070062 (EC: IDA)
has PubMed association: PMID: 1460020; 2037571; 7601477; 7607664; 8144040; 8619474; 9110174; 9519709; 10198162; 10806197; 10997685; 11587069; 11679416; 12477932; 12802498; 14988277; 15308130; 15489334; 15595739; 15613432; 15878746; 16341674; 16344560; 16964243; 17024311; 17081983; 17542649; 17941647; 18781797; 19059404; 19170765; 19322201; 20301347; 20562859; 20845477; 21139048; 21310273; 21890473; 21906983; 21988832; 22053931; 22505724; 22586326; 22863883; 22987706; 23000965; 23569079; 23794683; 24250222
description: glutamine--fructose-6-phosphate transaminase 1
database cross reference: Ensembl:ENSG00000198380
database cross reference: HGNC:4241
database cross reference: HPRD:00702
database cross reference: MIM:138292
database cross reference: Vega:OTTHUMG00000152666

GLB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: EBP
alternative term: ELNR1
alternative term: MPS4B
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GLB1
full name from nomenclature authority: galactosidase, beta 1
NCBI GeneID: 2720
gene map location: 3p21.33
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004565 (EC: TAS, PMID: 3143362); GO_0005515 (EC: IPI, PMID: 15498789); GO_0005737 (EC: IDA); GO_0005794 (EC: IDA); GO_0005975 (EC: TAS); GO_0006027 (EC: TAS); GO_0006665 (EC: TAS); GO_0006687 (EC: TAS); GO_0016936 (EC: IEA); GO_0019388 (EC: IEA); GO_0030203 (EC: TAS); GO_0042339 (EC: TAS); GO_0042340 (EC: TAS); GO_0043202 (EC: TAS); GO_0044281 (EC: TAS); GO_0048471 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 110522; 113895; 1353343; 1487238; 1606711; 1907800; 1909089; 1909871; 1928092; 2111707; 2511208; 3084469; 3102233; 3143362; 3921454; 3922758; 6791574; 6807121; 7586649; 7693577; 8125298; 8198123; 8199591; 8213816; 8383699; 8500799; 8670798; 8910459; 8922281; 9203065; 9497360; 9501080; 10338095; 10571006; 10737981; 10839995; 10841810; 10891505; 11511921; 12393180; 12477932; 12515396; 12644936; 14987258; 15365997; 15489334; 15498789; 15714521; 15907791; 16263699; 16314420; 16314480; 16344560; 16538002; 16626397; 16941474; 17309651; 17353931; 17522702; 17661814; 17664528; 18088383; 18217416; 18353697; 18524657; 18704747; 18772331; 18976701; 19056867; 19091613; 19472408; 19769716; 20000738; 20175788; 20379614; 20826101; 20920281; 20947500; 21105107; 21139048; 21321400; 21890473; 21900206; 21906983; 21963094; 21978926; 21988832; 22001501; 22033734; 22128166; 22178079; 22234367; 22268729; 22763966; 22908062; 23042114; 24156116; 24250222
description: galactosidase, beta 1
database cross reference: Ensembl:ENSG00000170266
database cross reference: HGNC:4298
database cross reference: HPRD:01975
database cross reference: MIM:611458
database cross reference: Vega:OTTHUMG00000155781

GNAQ
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CMC1
alternative term: G-ALPHA-q
alternative term: GAQ
alternative term: SWS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GNAQ
full name from nomenclature authority: guanine nucleotide binding protein (G protein), q polypeptide
NCBI GeneID: 2776
NCBI LocusTag: RP11-494N1.1
gene map location: 9q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001501 (EC: IEA); GO_0001508 (EC: IBA); GO_0001664 (EC: IBA); GO_0003924 (EC: IEA); GO_0004871 (EC: IBA); GO_0005096 (EC: IDA, PMID: 15611106); GO_0005515 (EC: IPI, PMID: 18672896); GO_0005525 (EC: IEA); GO_0005737 (EC: TAS, PMID: 9175863); GO_0005765 (EC: IDA, PMID: 17897319); GO_0005834 (EC: IBA); GO_0005886 (EC: TAS); GO_0006469 (EC: IMP); GO_0007189 (EC: IBA); GO_0007202 (EC: TAS, PMID: 8825633); GO_0007215 (EC: IBA); GO_0007507 (EC: IEA); GO_0007596 (EC: TAS); GO_0009791 (EC: IEA); GO_0016322 (EC: IEA); GO_0021884 (EC: IEA); GO_0030168 (EC: TAS); GO_0031234 (EC: IBA); GO_0031683 (EC: IBA); GO_0031965 (EC: IEA); GO_0035412 (EC: IMP); GO_0042711 (EC: IEA); GO_0042733 (EC: IEA); GO_0043547 (EC: IDA, PMID: 15611106); GO_0045634 (EC: IEA); GO_0046872 (EC: IEA); GO_0048066 (EC: IEA); GO_0050821 (EC: IMP); GO_0060158 (EC: IBA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1322796; 1333286; 1851174; 2841328; 7492305; 7629074; 7791744; 7937899; 8188646; 8227063; 8504751; 8552586; 8655576; 8664309; 8825633; 8836152; 8863838; 8923415; 8982657; 9061052; 9152406; 9175863; 9198220; 9238049; 9405622; 9481484; 9488690; 9660808; 9685625; 9700850; 9770463; 10446129; 10488065; 10550060; 10598591; 10633085; 10728414; 11076863; 11118617; 11194358; 11253162; 11278452; 11375483; 11408001; 11443126; 11686331; 11753430; 11812005; 11848441; 11875076; 11895442; 11916537; 11955952; 11981043; 12016230; 12130679; 12193606; 12399457; 12477932; 12496284; 12509430; 12626493; 12629551; 12650852; 12652642; 12670932; 12670961; 12704201; 12711604; 12714438; 12726995; 12748287; 12807915; 12885252; 14561750; 14617636; 14634662; 14702039; 15115661; 15134434; 15251452; 15322542; 15383626; 15466861; 15471870; 15489336; 15611106; 15694379; 15698833; 15735747; 15782186; 15794946; 16038796; 16102047; 16218966; 16381901; 16481068; 16629901; 16650966; 16860758; 16893886; 16995904; 17197445; 17255364; 17307333; 17498700; 17535809; 17552882; 17606614; 17720980; 17846866; 17897319; 18096806; 18240029; 18322150; 18326504; 18424071; 18434368; 18514160; 18577758; 18632858; 18672896; 18719078; 18851832; 18936096; 18989526; 18991294; 19056867; 19074439; 19074441; 19078957; 19332487; 19426503; 19445628; 19551532; 19654573; 19718445; 19903011; 19936769; 20007712; 20133939; 20237586; 20379146; 20399743; 20562673; 20590159; 20631239; 20664004; 20714830; 20805136; 20865267; 21056896; 21072599; 21083380; 21139048; 21304157; 21366456; 21464134; 21487925; 21515378; 21592972; 21906983; 21940795; 21945171; 21963094; 21988832; 22056876; 22253748; 22307269; 22701657; 22710260; 22758774; 22905097; 22939629; 22977135; 23066026; 23159116; 23315865; 23572068; 23572156; 23634288; 23656586; 23665327; 23685997; 23778528; 23884432
description: guanine nucleotide binding protein (G protein), q polypeptide
database cross reference: HGNC:4390
database cross reference: HPRD:02998
database cross reference: MIM:600998

GOT1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ASTQTL1
alternative term: GIG18
alternative term: cAspAT
alternative term: cCAT
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GOT1
full name from nomenclature authority: glutamic-oxaloacetic transaminase 1, soluble
NCBI GeneID: 2805
gene map location: 10q24.1-q25.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000096 (EC: TAS); GO_0004069 (EC: IDA, PMID: 2182221); GO_0004069 (EC: ISS); GO_0004069 (EC: TAS); GO_0004609 (EC: IEA); GO_0005737 (EC: IDA, PMID: 7060339); GO_0005764 (EC: IEA); GO_0005829 (EC: TAS); GO_0005975 (EC: TAS); GO_0006006 (EC: TAS); GO_0006094 (EC: TAS); GO_0006103 (EC: ISS); GO_0006107 (EC: IEA); GO_0006114 (EC: ISS); GO_0006531 (EC: ISS); GO_0006532 (EC: IEA); GO_0006533 (EC: IDA, PMID: 2241899); GO_0006536 (EC: ISS); GO_0006595 (EC: TAS); GO_0008483 (EC: TAS); GO_0008652 (EC: TAS); GO_0019509 (EC: TAS); GO_0019550 (EC: IEA); GO_0019551 (EC: IEA); GO_0030170 (EC: IEA); GO_0031406 (EC: IEA); GO_0032869 (EC: IEP, PMID: 8396422); GO_0034641 (EC: TAS); GO_0043679 (EC: IEA); GO_0044281 (EC: TAS); GO_0047801 (EC: ISS); GO_0051384 (EC: IEP, PMID: 8396422); GO_0055089 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0080130 (EC: IEA)
has PubMed association: PMID: 225064; 1974457; 2182221; 2225456; 2241899; 2731362; 2777255; 3207426; 6391741; 6397370; 7060339; 8349677; 8396422; 8619474; 9110174; 10360399; 12477932; 12480555; 15164054; 15306699; 15489334; 16169070; 16344560; 16681433; 17623298; 17877759; 17907318; 18242760; 18752324; 19012630; 19056867; 19370784; 19393479; 20029029; 20201926; 20205615; 20499337; 20972737; 21139048; 21750724; 21900944; 21906983; 21963094; 21988832; 22132177; 22242166; 22352690; 22412388; 22863883; 23667618; 24124411
description: glutamic-oxaloacetic transaminase 1, soluble
database cross reference: Ensembl:ENSG00000120053
database cross reference: HGNC:4432
database cross reference: HPRD:00687
database cross reference: MIM:138180
database cross reference: Vega:OTTHUMG00000018882

GOT2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: KAT4
alternative term: KATIV
alternative term: mitAAT
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GOT2
full name from nomenclature authority: glutamic-oxaloacetic transaminase 2, mitochondrial
NCBI GeneID: 2806
gene map location: 16q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004069 (EC: EXP); GO_0004069 (EC: IDA, PMID: 2182221); GO_0004069 (EC: ISS); GO_0005739 (EC: IDA); GO_0005739 (EC: ISS); GO_0005743 (EC: IEA); GO_0005759 (EC: TAS); GO_0005886 (EC: IDA, PMID: 9537447); GO_0005975 (EC: TAS); GO_0006006 (EC: TAS); GO_0006094 (EC: TAS); GO_0006103 (EC: ISS); GO_0006107 (EC: IEA); GO_0006531 (EC: ISS); GO_0006532 (EC: IEA); GO_0006533 (EC: IDA, PMID: 2567216); GO_0006536 (EC: ISS); GO_0008652 (EC: TAS); GO_0015908 (EC: IEP, PMID: 9537447); GO_0016212 (EC: IEA); GO_0019470 (EC: TAS); GO_0019550 (EC: IEA); GO_0019551 (EC: IEA); GO_0030170 (EC: IEA); GO_0034641 (EC: TAS); GO_0044281 (EC: TAS); GO_0044822 (EC: IDA); GO_0045471 (EC: IDA, PMID: 9537447); GO_0070062 (EC: IDA); GO_0080130 (EC: IEA)
has PubMed association: PMID: 376500; 752471; 2182221; 2567216; 2731362; 2777255; 2899080; 3207426; 3997814; 4052435; 5450376; 6397370; 6930651; 7114792; 7225087; 7559589; 8125298; 8349677; 9537447; 12477932; 12601813; 14702039; 15489334; 16169070; 16212419; 17353931; 17442055; 17728674; 17877759; 18781797; 19305408; 19834535; 20360068; 20877624; 21081666; 21139048; 21223598; 21319273; 21890473; 21900206; 21906983; 21963094; 22713574; 23000965
description: glutamic-oxaloacetic transaminase 2, mitochondrial
database cross reference: Ensembl:ENSG00000125166
database cross reference: HGNC:4433
database cross reference: HPRD:00684
database cross reference: MIM:138150
database cross reference: Vega:OTTHUMG00000133769

GPI
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AMF
alternative term: GNPI
alternative term: NLK
alternative term: PGI
alternative term: PHI
alternative term: SA-36
alternative term: SA36
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GPI
full name from nomenclature authority: glucose-6-phosphate isomerase
NCBI GeneID: 2821
gene map location: 19q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001525 (EC: IEA); GO_0004347 (EC: TAS); GO_0005125 (EC: IEA); GO_0005615 (EC: IEA); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA); GO_0005975 (EC: TAS); GO_0006006 (EC: TAS); GO_0006094 (EC: TAS); GO_0006096 (EC: IEA); GO_0006096 (EC: TAS); GO_0006959 (EC: TAS, PMID: 3020690); GO_0007599 (EC: TAS, PMID: 7435496); GO_0007611 (EC: IEA); GO_0008083 (EC: IEA); GO_0016866 (EC: IEA); GO_0019242 (EC: IEA); GO_0043005 (EC: IEA); GO_0043154 (EC: IEA); GO_0043524 (EC: IEA); GO_0044281 (EC: TAS); GO_0046185 (EC: IEA); GO_0048029 (EC: IEA); GO_0051156 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 2387591; 2544027; 2547084; 3020690; 3352745; 7435496; 7545951; 7989588; 8499925; 8575767; 8822952; 8822954; 8889548; 9446754; 9616041; 9856489; 10216265; 10727272; 10916680; 11004567; 11264592; 11418246; 11431735; 11688991; 11896391; 11896393; 12054796; 12477932; 12517804; 12527360; 12573240; 12737943; 12783864; 14566819; 14715248; 15034067; 15059907; 15290745; 15369782; 15489334; 15570012; 15576338; 15637053; 15850830; 16009940; 16196087; 16563432; 16949042; 17041899; 17071500; 17690101; 17875708; 17925402; 18029348; 18311788; 18485900; 18781797; 18992137; 19056867; 19064002; 19531650; 19787266; 19801670; 19819066; 20237496; 20360068; 20810510; 20845477; 20849852; 20978190; 21139048; 21252914; 21319273; 21555518; 21890473; 21906983; 21963094; 21970785; 21987572; 22053931; 22261722; 22360420; 22505724; 22939629; 23000965; 23248119; 23773638; 23824909
description: glucose-6-phosphate isomerase
database cross reference: Ensembl:ENSG00000105220
database cross reference: HGNC:4458
database cross reference: HPRD:01394
database cross reference: MIM:172400
database cross reference: Vega:OTTHUMG00000182087

CXCR3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD182
alternative term: CD183
alternative term: CKR-L2
alternative term: CMKAR3
alternative term: GPR9
alternative term: IP10-R
alternative term: Mig-R
alternative term: MigR
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CXCR3
full name from nomenclature authority: chemokine (C-X-C motif) receptor 3
NCBI GeneID: 2833
gene map location: Xq13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001525 (EC: IEA); GO_0001937 (EC: IDA, PMID: 12782716); GO_0002685 (EC: IEA); GO_0004872 (EC: IDA, PMID: 12782716); GO_0004950 (EC: TAS, PMID: 9064356); GO_0005737 (EC: TAS, PMID: 10903743); GO_0005886 (EC: IDA, PMID: 12782716); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 9064356); GO_0006915 (EC: IEA); GO_0006928 (EC: TAS, PMID: 10741397); GO_0006935 (EC: TAS, PMID: 10903763); GO_0006954 (EC: IEA); GO_0007155 (EC: TAS, PMID: 10942362); GO_0007166 (EC: IDA, PMID: 11554781); GO_0007186 (EC: IMP, PMID: 12782716); GO_0007204 (EC: IEA); GO_0008284 (EC: IDA, PMID: 12782716); GO_0009897 (EC: IEA); GO_0010818 (EC: IEA); GO_0016494 (EC: IEA); GO_0016525 (EC: IDA, PMID: 12782716); GO_0019722 (EC: IEA); GO_0019956 (EC: IPI, PMID: 11554781); GO_0019958 (EC: IDA, PMID: 12782716); GO_0030816 (EC: IDA, PMID: 12782716); GO_0043950 (EC: IDA, PMID: 12782716); GO_0045766 (EC: IDA, PMID: 12782716); GO_0045944 (EC: IDA, PMID: 12782716); GO_0050921 (EC: IDA, PMID: 12782716); GO_0051281 (EC: IMP, PMID: 12782716); GO_0071954 (EC: IDA, PMID: 12782716); GO_1900118 (EC: IDA, PMID: 12782716); GO_1900119 (EC: IDA, PMID: 12782716)
has PubMed association: PMID: 2834384; 8666380; 9064356; 9419219; 9466968; 9625760; 9660793; 10233762; 10393705; 10627472; 10666479; 10741397; 10900358; 10903743; 10903763; 10942362; 11083865; 11134180; 11160352; 11196695; 11554781; 11559369; 11714650; 11739530; 11966764; 11990865; 12016104; 12055238; 12070001; 12097412; 12270371; 12356205; 12425561; 12444109; 12445801; 12477932; 12517959; 12571234; 12688353; 12750173; 12782716; 12819030; 12884299; 12919091; 12953097; 12960247; 12960302; 14578618; 14618028; 14630801; 14657006; 14742268; 15126579; 15150261; 15155273; 15181567; 15254596; 15265234; 15273303; 15328188; 15489334; 15501397; 15518810; 15528361; 15578697; 15687242; 15713799; 15725351; 15808644; 15843529; 15856455; 15879427; 15885315; 16033640; 16034118; 16043121; 16127166; 16243485; 16339779; 16368892; 16455991; 16456020; 16679918; 16733654; 16787707; 16806233; 16847335; 16861617; 16930533; 16934957; 17018607; 17142783; 17142784; 17251291; 17339184; 17363734; 17457216; 17560677; 17615381; 17666357; 17703412; 17912012; 17947699; 18037659; 18174362; 18240029; 18280341; 18291705; 18375741; 18453591; 18485912; 18497951; 18616679; 18689270; 18729739; 18761554; 18798334; 18832436; 18962861; 19017998; 19106589; 19134328; 19232748; 19258923; 19344719; 19380511; 19539215; 19641142; 19703720; 19734217; 19735481; 19758167; 19767105; 19800124; 20041963; 20047517; 20059481; 20079227; 20096889; 20164417; 20185576; 20203286; 20228225; 20237496; 20377416; 20379873; 20429924; 20485444; 20503287; 20529825; 20733031; 20848514; 20855888; 20856926; 20980681; 21051441; 21087446; 21091908; 21148743; 21255008; 21274647; 21303425; 21303517; 21357438; 21426802; 21538345; 21645215; 21739422; 21811993; 21962843; 22079021; 22111598; 22236567; 22262158; 22369302; 22392992; 22401929; 22675496; 22685032; 22689289; 22792160; 22796894; 22798340; 22936405; 23121557; 23158864; 23179902; 23298254; 23600831; 23643635; 24129241; 24135023
description: chemokine (C-X-C motif) receptor 3
database cross reference: Ensembl:ENSG00000186810
database cross reference: HGNC:4540
database cross reference: HPRD:02936
database cross reference: MIM:300574
database cross reference: Vega:OTTHUMG00000033326

GPX1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GPXD
alternative term: GSHPX1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GPX1
full name from nomenclature authority: glutathione peroxidase 1
NCBI GeneID: 2876
gene map location: 3p21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001659 (EC: IEA); GO_0001885 (EC: IEA); GO_0002862 (EC: IEA); GO_0004602 (EC: IDA, PMID: 12829378); GO_0004602 (EC: TAS); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA); GO_0005739 (EC: IDA, PMID: 10833429); GO_0005759 (EC: TAS); GO_0005829 (EC: TAS); GO_0006144 (EC: TAS); GO_0006195 (EC: TAS); GO_0006641 (EC: IEA); GO_0006749 (EC: IDA, PMID: 12829378); GO_0006982 (EC: IEA); GO_0007568 (EC: IEA); GO_0007605 (EC: IEA); GO_0008430 (EC: IEA); GO_0008631 (EC: IEA); GO_0009410 (EC: IEA); GO_0009609 (EC: IEA); GO_0009636 (EC: IEA); GO_0009650 (EC: IMP, PMID: 17097614); GO_0009749 (EC: IEA); GO_0010269 (EC: IMP, PMID: 12810669); GO_0010332 (EC: IEA); GO_0017124 (EC: IPI, PMID: 12893824); GO_0018158 (EC: IEA); GO_0019369 (EC: TAS); GO_0019372 (EC: TAS); GO_0032355 (EC: IEA); GO_0033599 (EC: IMP, PMID: 16945136); GO_0035094 (EC: IEA); GO_0040029 (EC: IDA, PMID: 16132718); GO_0042311 (EC: IEA); GO_0042542 (EC: IMP, PMID: 12829378); GO_0042744 (EC: IDA, PMID: 15203190); GO_0043066 (EC: IEA); GO_0043154 (EC: IMP, PMID: 12221075); GO_0043295 (EC: IEA); GO_0043403 (EC: IEA); GO_0043523 (EC: IEA); GO_0043534 (EC: IEA); GO_0044281 (EC: TAS); GO_0045444 (EC: IEA); GO_0045454 (EC: IDA, PMID: 12829378); GO_0047066 (EC: IEA); GO_0048741 (EC: IEA); GO_0051450 (EC: IEA); GO_0051593 (EC: IEA); GO_0051702 (EC: IEA); GO_0051897 (EC: IEA); GO_0055086 (EC: TAS); GO_0060047 (EC: IMP, PMID: 14573732); GO_0060055 (EC: IEA); GO_0061136 (EC: IDA, PMID: 12751788); GO_0090201 (EC: IMP, PMID: 12221075); GO_1902042 (EC: IMP, PMID: 12221075); GO_1902176 (EC: IEA)
has PubMed association: PMID: 1556108; 2307470; 2955287; 2976939; 3658677; 3697069; 8001233; 8125298; 8428933; 9126277; 9501919; 9605859; 10220143; 10652368; 10833429; 10880344; 11103801; 11112379; 11368344; 11823528; 12221075; 12447480; 12470500; 12477932; 12496980; 12531513; 12655278; 12732844; 12751788; 12787913; 12810669; 12829378; 12832449; 12893824; 12893830; 14573732; 14671197; 14744747; 14962293; 14962975; 15125229; 15149466; 15167446; 15192016; 15203190; 15247771; 15295091; 15298967; 15318035; 15331559; 15489334; 15774926; 15829318; 15878749; 15910762; 15946795; 15990458; 16132718; 16230136; 16287877; 16354666; 16413612; 16424062; 16523188; 16538174; 16543247; 16614101; 16615267; 16627788; 16797832; 16868544; 16871233; 16945136; 16956821; 16979635; 17052796; 17097614; 17149600; 17171548; 17275003; 17334644; 17336361; 17526193; 17548672; 17601350; 17625244; 17634480; 17693525; 17825092; 17850515; 18186040; 18267129; 18298806; 18417962; 18449862; 18469277; 18483336; 18541150; 18541588; 18563616; 18600213; 18676680; 18806750; 18853169; 18940188; 18977241; 19012493; 19026164; 19035188; 19056482; 19124506; 19125369; 19161995; 19170196; 19195504; 19195803; 19228881; 19254950; 19285650; 19347979; 19415410; 19423521; 19424819; 19428376; 19428448; 19488773; 19505917; 19527700; 19560448; 19573080; 19578796; 19625176; 19692168; 19705749; 19733578; 19773279; 19819955; 19826042; 19896490; 19913121; 19929244; 19944066; 19946932; 19949914; 19951064; 20041472; 20082261; 20097730; 20109103; 20178852; 20200426; 20219985; 20301895; 20303587; 20306294; 20307617; 20378690; 20441054; 20444272; 20471990; 20477822; 20480816; 20530237; 20578157; 20628086; 20643115; 20644561; 20724907; 20727719; 20802378; 20813000; 20851292; 20852007; 20877264; 20877624; 20878976; 21045266; 21048031; 21052528; 21053180; 21055077; 21087145; 21102463; 21165435; 21185702; 21292323; 21434422; 21586620; 21636625; 21842217; 21852236; 21900206; 21904836; 21921984; 21936966; 21989715; 21993316; 22036626; 22072582; 22167619; 221800…
description: glutathione peroxidase 1
database cross reference: Ensembl:ENSG00000233276
database cross reference: HGNC:4553
database cross reference: HPRD:11749
database cross reference: MIM:138320
database cross reference: Vega:OTTHUMG00000156837

GRN
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CLN11
alternative term: GEP
alternative term: GP88
alternative term: PCDGF
alternative term: PEPI
alternative term: PGRN
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GRN
full name from nomenclature authority: granulin
NCBI GeneID: 2896
gene map location: 17q21.32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001835 (EC: IEA); GO_0005125 (EC: IEA); GO_0005515 (EC: IPI); GO_0005615 (EC: IEA); GO_0005739 (EC: IEA); GO_0007165 (EC: NAS, PMID: 1542665); GO_0007566 (EC: IEA); GO_0008083 (EC: TAS, PMID: 1542665); GO_0008219 (EC: IEA); GO_0043231 (EC: IDA); GO_0044822 (EC: IDA); GO_0050679 (EC: IEA)
has PubMed association: PMID: 1417868; 1542665; 1618805; 2268320; 8125298; 8471244; 8471426; 8496151; 8619474; 8912679; 9110174; 9826678; 10079180; 10397269; 10477733; 10715107; 10728698; 11068878; 11549288; 11846389; 12031912; 12477932; 12526812; 12538450; 12588988; 12900424; 12914763; 12931033; 14652816; 14702039; 14977833; 15231748; 15489334; 15569995; 15653695; 16189514; 16533762; 16713569; 16857791; 16862115; 16862116; 16950801; 16983677; 16983685; 17110338; 17157414; 17166276; 17202431; 17210807; 17228326; 17261172; 17266030; 17278999; 17291356; 17345602; 17353379; 17371905; 17383054; 17417739; 17436289; 17439980; 17458552; 17522386; 17572900; 17620546; 17698705; 17826340; 17949857; 17950702; 17984093; 18029348; 18157829; 18166610; 18183624; 18184915; 18192287; 18223198; 18234697; 18245784; 18276110; 18314228; 18322394; 18359860; 18378771; 18392865; 18413467; 18413474; 18442119; 18464284; 18479928; 18543312; 18551524; 18565828; 18593276; 18654987; 18706200; 18723384; 18723524; 18752597; 18768919; 18771956; 18838661; 18848708; 18855025; 18955727; 19012866; 19016491; 19020205; 19049508; 19056610; 19091059; 19101631; 19133655; 19158106; 19179604; 19237611; 19255408; 19321167; 19343720; 19446372; 19473366; 19487464; 19618231; 19625741; 19632744; 19649643; 19730170; 19730171; 19795409; 19847305; 19858458; 19863344; 19864668; 19913121; 19938685; 19940479; 19963041; 20020531; 20028451; 20045477; 20054825; 20061636; 20087814; 20142524; 20142525; 20154673; 20171924; 20197700; 20215705; 20237496; 20301545; 20301601; 20387302; 20463744; 20479936; 20489155; 20570546; 20628086; 20682318; 20711061; 20798611; 20858962; 20884628; 20930269; 20930271; 20933034; 20947212; 20975516; 21047645; 21078624; 21085476; 21087763; 21107132; 21123963; 21178100; 21204008; 21212639; 21224065; 21232819; 21258152; 21263192; 21289198; 21319273; 21393509; 21454553; 21482928; 21645364; 21677378; 21707777; 21753165; 21800185; 21802097; 21813674; 21891865; 21891869; 21892962; 21942715; 21988832; 22032330; 22045426; 220681…
description: granulin
database cross reference: Ensembl:ENSG00000030582
database cross reference: HGNC:4601
database cross reference: HPRD:00733
database cross reference: MIM:138945
database cross reference: Vega:OTTHUMG00000181816

GRIN2A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: EPND
alternative term: FESD
alternative term: GluN2A
alternative term: LKS
alternative term: NMDAR2A
alternative term: NR2A
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GRIN2A
full name from nomenclature authority: glutamate receptor, ionotropic, N-methyl D-aspartate 2A
NCBI GeneID: 2903
NCBI LocusTag: RP11-297M9.2
gene map location: 16p13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001964 (EC: IEA); GO_0001975 (EC: IEA); GO_0004972 (EC: IBA); GO_0005234 (EC: IBA); GO_0005262 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11937501); GO_0005783 (EC: IEA); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 8768735); GO_0006810 (EC: TAS, PMID: 8768735); GO_0007215 (EC: TAS, PMID: 8768735); GO_0007268 (EC: TAS); GO_0007611 (EC: TAS, PMID: 7816096); GO_0007613 (EC: IEA); GO_0008021 (EC: IEA); GO_0008104 (EC: IEA); GO_0008270 (EC: ISS); GO_0008542 (EC: IEA); GO_0009611 (EC: IEA); GO_0009986 (EC: ISS); GO_0017146 (EC: IDA, PMID: 10480938); GO_0019233 (EC: IEA); GO_0022008 (EC: IEA); GO_0030054 (EC: IEA); GO_0030425 (EC: IBA); GO_0030431 (EC: IEA); GO_0033058 (EC: IEA); GO_0034220 (EC: IBA); GO_0035235 (EC: IBA); GO_0035249 (EC: IBA); GO_0042177 (EC: IEA); GO_0042417 (EC: IEA); GO_0042428 (EC: IEA); GO_0042493 (EC: IEA); GO_0042734 (EC: IEA); GO_0043065 (EC: IEA); GO_0045211 (EC: IBA); GO_0045471 (EC: IDA, PMID: 18445116); GO_0048167 (EC: IEA); GO_0051930 (EC: IEA); GO_0060079 (EC: IEA); GO_0097481 (EC: IEA)
has PubMed association: PMID: 1350383; 7524031; 7569905; 7695237; 7816096; 8061049; 8139656; 8163463; 8267632; 8563977; 8581564; 8601796; 8615909; 8665664; 8724036; 8768735; 8804048; 8821747; 8822372; 8845955; 8955056; 9231720; 9278515; 9286858; 9480759; 9481670; 9647694; 9651389; 9670010; 9745929; 9892651; 10195142; 10197777; 10336672; 10373510; 10448428; 10458595; 10479680; 10480938; 10555109; 10648730; 10748123; 10846184; 10862698; 10884433; 11104776; 11222640; 11279200; 11478920; 11483648; 11606043; 11675505; 11803122; 11854440; 11937501; 11985816; 12008020; 12068077; 12070168; 12082569; 12127670; 12147342; 12191494; 12391275; 12414113; 12419528; 12477932; 12531901; 12576483; 12697264; 12724619; 12775422; 12815021; 12890763; 12893641; 12923170; 12932824; 12933808; 12956718; 14622581; 14644469; 14699423; 14702039; 14732708; 14966475; 15254094; 15681389; 15742215; 15749123; 15774266; 15830322; 15888440; 16266783; 16476413; 16481105; 16489129; 16637659; 16697675; 16990796; 17011703; 17018562; 17081983; 17105731; 17255096; 17360663; 17433503; 17519952; 17569088; 17922030; 17942280; 17997397; 18029348; 18178157; 18445116; 18570704; 18606955; 18990687; 18991843; 19020013; 19036954; 19058789; 19086053; 19088076; 19156168; 19268276; 19352218; 19526283; 19834457; 19874574; 20041166; 20070378; 20094923; 20148871; 20379614; 20398908; 20448061; 20468064; 20677014; 20848605; 20890276; 21152063; 21371516; 21491143; 21499247; 21507155; 21670103; 21876681; 21883175; 21906983; 21948112; 22004137; 22114277; 22142193; 22486492; 22552781; 22833210; 22851457; 22940423; 23400010; 23453885; 23639431; 23693003; 23847085; 23933818; 23933819; 23933820; 23940648; 24227730
description: glutamate receptor, ionotropic, N-methyl D-aspartate 2A
database cross reference: Ensembl:ENSG00000183454
database cross reference: HGNC:4585
database cross reference: HPRD:00698
database cross reference: MIM:138253
database cross reference: Vega:OTTHUMG00000129721

GRIN2B
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GluN2B
alternative term: MRD6
alternative term: NMDAR2B
alternative term: NR2B
alternative term: hNR3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GRIN2B
full name from nomenclature authority: glutamate receptor, ionotropic, N-methyl D-aspartate 2B
NCBI GeneID: 2904
gene map location: 12p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001662 (EC: IEA); GO_0001701 (EC: IEA); GO_0001964 (EC: IEA); GO_0001967 (EC: IEA); GO_0004972 (EC: IBA); GO_0005234 (EC: IBA); GO_0005262 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11937501); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 8768735); GO_0006810 (EC: TAS, PMID: 8768735); GO_0007215 (EC: TAS, PMID: 8768735); GO_0007268 (EC: TAS); GO_0007423 (EC: IEA); GO_0007611 (EC: TAS, PMID: 10485705); GO_0007612 (EC: IEA); GO_0007613 (EC: IEA); GO_0008021 (EC: IEA); GO_0008270 (EC: ISS); GO_0009986 (EC: ISS); GO_0014069 (EC: IEA); GO_0016594 (EC: IDA, PMID: 17047094); GO_0017146 (EC: IDA, PMID: 10480938); GO_0030054 (EC: IEA); GO_0030425 (EC: IBA); GO_0034220 (EC: IBA); GO_0035235 (EC: IBA); GO_0035249 (EC: IBA); GO_0043005 (EC: ISS); GO_0045211 (EC: IBA); GO_0045471 (EC: IDA, PMID: 18445116); GO_0048167 (EC: IEA); GO_0048266 (EC: IEA); GO_0050966 (EC: IEA); GO_0060079 (EC: IEA)
has PubMed association: PMID: 1350383; 7569905; 7695237; 7959773; 7999784; 8139656; 8163463; 8563977; 8581564; 8601796; 8615909; 8665664; 8724036; 8768735; 8780649; 8804048; 8821747; 8822372; 8845955; 8940188; 8955056; 9009191; 9231720; 9278515; 9326658; 9427503; 9481670; 9547169; 9581762; 9620694; 9647694; 9651389; 9670010; 9745929; 9806853; 10197777; 10341223; 10373510; 10381539; 10448428; 10458595; 10479680; 10480938; 10485705; 10488080; 10555109; 10620012; 10748157; 10846184; 10884433; 11024032; 11029657; 11278603; 11306676; 11317224; 11459059; 11483648; 11483655; 11588171; 11606043; 11679592; 11723117; 11799243; 11807413; 11844890; 11937501; 11956967; 11979061; 11997254; 12082569; 12127670; 12147342; 12191494; 12391275; 12414113; 12476325; 12477932; 12524444; 12531901; 12556902; 12650977; 12738960; 12753378; 12775422; 12815021; 12824739; 12857875; 12890763; 12893641; 14573320; 14622581; 14644469; 14662797; 15030493; 15083261; 15180478; 15211626; 15254094; 15489334; 15542698; 15673434; 15721239; 15742215; 15749123; 15812607; 15841096; 15866054; 16120608; 16266783; 16289038; 16380905; 16436603; 16481105; 16489129; 16549338; 16697675; 16766085; 16870468; 16911840; 16990796; 17010153; 17047094; 17224684; 17255096; 17360663; 17506933; 17506987; 17569088; 17620329; 17669510; 17942280; 17962190; 17997397; 18007143; 18068304; 18303265; 18445116; 18583979; 18606955; 18836292; 18976975; 18983893; 18991843; 19005876; 19011431; 19020013; 19036954; 19086053; 19088076; 19095845; 19156168; 19167335; 19192303; 19268276; 19279257; 19324536; 19328558; 19336002; 19350219; 19367581; 19453375; 19523047; 19526283; 19562769; 19591125; 19605943; 19726645; 19734545; 19784770; 19874574; 20175224; 20197096; 20201926; 20347576; 20379614; 20399867; 20421849; 20427279; 20438806; 20464528; 20468064; 20537720; 20537986; 20848605; 20859245; 20882066; 20890276; 20939817; 20945430; 20957330; 21116278; 21491143; 21597037; 21639937; 21670103; 21704719; 21749895; 21753020; 21782286; 21789901; 21827795; 21919190; 21948112;…
description: glutamate receptor, ionotropic, N-methyl D-aspartate 2B
database cross reference: HGNC:4586
database cross reference: HPRD:00697
database cross reference: MIM:138252

NR3C1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GCCR
alternative term: GCR
alternative term: GR
alternative term: GRL
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NR3C1
full name from nomenclature authority: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NCBI GeneID: 2908
gene map location: 5q31.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003700 (EC: IEA); GO_0004883 (EC: IEA); GO_0005496 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10364267); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005759 (EC: TAS, PMID: 10887960); GO_0005829 (EC: IEA); GO_0006111 (EC: IEA); GO_0006351 (EC: TAS, PMID: 10887960); GO_0006355 (EC: IDA, PMID: 19141540); GO_0006366 (EC: TAS, PMID: 8621628); GO_0006367 (EC: TAS); GO_0007165 (EC: TAS, PMID: 7769088); GO_0008211 (EC: IEA); GO_0008270 (EC: IEA); GO_0010467 (EC: TAS); GO_0016020 (EC: IEA); GO_0016568 (EC: IEA); GO_0030325 (EC: IEA); GO_0031946 (EC: IEA); GO_0043525 (EC: IEA); GO_0043565 (EC: IEA); GO_0046983 (EC: IEA); GO_0060603 (EC: IEA)
has PubMed association: PMID: 1152650; 1469072; 1562545; 1612132; 1704018; 1707881; 1865905; 1958537; 2019585; 2026589; 2793174; 2867473; 3597702; 3841189; 6261922; 6266631; 6509026; 6621034; 7254211; 7264103; 7295795; 7491111; 7621901; 7659084; 7683692; 7724608; 7769088; 7796394; 7823959; 7873448; 7877627; 7887964; 8051160; 8089152; 8107808; 8125298; 8157642; 8223438; 8269959; 8288028; 8290595; 8316249; 8341706; 8349631; 8358712; 8358735; 8445027; 8449898; 8530516; 8621522; 8621628; 8645634; 8733011; 8800208; 8863343; 8878484; 8898375; 9038175; 9079630; 9089287; 9115274; 9128241; 9148915; 9150737; 9154805; 9162033; 9195923; 9199329; 9215863; 9261129; 9334248; 9334723; 9348235; 9353307; 9388192; 9426156; 9435432; 9482670; 9528750; 9584182; 9590696; 9603979; 9637764; 9649342; 9671457; 9703718; 9742105; 9817600; 9873044; 9874563; 9915858; 9920895; 9928932; 10066374; 10085091; 10187825; 10359081; 10364267; 10391209; 10430878; 10477749; 10480874; 10490647; 10508170; 10517667; 10518526; 10566686; 10567404; 10601862; 10639135; 10659697; 10688647; 10691735; 10713165; 10713182; 10731636; 10784585; 10848625; 10866662; 10887960; 10898924; 10902803; 10903152; 10903900; 10933727; 10958685; 10995388; 11005817; 11027313; 11080152; 11096094; 11101523; 11117529; 11119758; 11146632; 11152650; 11154266; 11158330; 11162542; 11229437; 11238589; 11250851; 11266503; 11279115; 11287026; 11344238; 11358809; 11358960; 11435610; 11463861; 11555652; 11562347; 11571596; 11589680; 11591700; 11673782; 11689055; 11701741; 11704662; 11708406; 11710540; 11711524; 11739747; 11751894; 11792840; 11812797; 11818365; 11873873; 11932321; 11971959; 11983486; 11996936; 12000743; 12011091; 12039077; 12039962; 12050230; 12093808; 12099703; 12114257; 12114309; 12118039; 12144530; 12145329; 12151000; 12193561; 12208951; 12225995; 12237016; 12237292; 12351458; 12351702; 12361945; 12379213; 12430185; 12444143; 12466272; 12477485; 12477932; 12487626; 12490527; 12552091; 12569182; 12581885; 12595526; 12612067; 12623935; 12634356; 1263749…
description: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
database cross reference: Ensembl:ENSG00000113580
database cross reference: HGNC:7978
database cross reference: HPRD:00679
database cross reference: MIM:138040
database cross reference: Vega:OTTHUMG00000129677

CXCL1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FSP
alternative term: GRO1
alternative term: GROa
alternative term: MGSA
alternative term: MGSA-a
alternative term: NAP-3
alternative term: SCYB1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CXCL1
full name from nomenclature authority: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
NCBI GeneID: 2919
gene map location: 4q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005102 (EC: TAS, PMID: 10820279); GO_0005576 (EC: TAS); GO_0005615 (EC: IEA); GO_0006935 (EC: TAS, PMID: 10820279); GO_0006954 (EC: IEA); GO_0006955 (EC: IEA); GO_0007165 (EC: TAS, PMID: 10820279); GO_0007186 (EC: TAS, PMID: 10820279); GO_0007399 (EC: TAS, PMID: 9058825); GO_0008009 (EC: IEA); GO_0008047 (EC: TAS, PMID: 9079638); GO_0008083 (EC: IEA); GO_0008283 (EC: TAS, PMID: 8380167); GO_0008285 (EC: TAS, PMID: 9551928); GO_0030036 (EC: TAS, PMID: 9725262); GO_0035556 (EC: TAS, PMID: 9551928); GO_0043085 (EC: TAS, PMID: 9079638); GO_0060326 (EC: TAS, PMID: 10820279)
has PubMed association: PMID: 1379593; 1906501; 2129556; 2182761; 2217207; 2655583; 2670560; 2890161; 2909392; 2970963; 3264403; 7561066; 7592830; 7806518; 8089846; 8380167; 8397104; 8550564; 8597869; 8702798; 8940121; 8942852; 9058825; 9079638; 9152234; 9551928; 9725262; 10095777; 10343098; 10437780; 10820279; 10881932; 11023497; 11349045; 11390582; 11470861; 11524231; 11816717; 12012624; 12089333; 12388718; 12477932; 12591113; 12734381; 12744776; 13679391; 14530367; 15133028; 15218300; 15340161; 15489334; 15492419; 15843053; 15896780; 15994316; 16086366; 16098041; 16567391; 16617094; 16712791; 16934308; 16941962; 17022986; 17060621; 17062666; 17096385; 17456471; 17466952; 17581194; 17703315; 17703412; 17999991; 18056965; 18065201; 18211687; 18240029; 18276907; 18283335; 18451219; 18577758; 19103522; 19176759; 19258312; 19258923; 19430878; 19435811; 19549892; 19780053; 19838218; 19906815; 20042592; 20195728; 20237496; 20495539; 20503287; 20621720; 20628624; 20685145; 20702723; 20731665; 21042742; 21075844; 21220697; 21257927; 21343381; 21396766; 21531038; 21820916; 21928244; 21994122; 22030312; 22069268; 22125641; 22129625; 22173151; 22183310; 22251138; 22615136; 22732298; 22770218; 22902060; 22975476; 23027620; 23043537; 23128233; 23198952; 23207068; 23225384; 23269549; 23334998; 23389772; 23444042; 23479735; 23505918; 23519936; 23554905; 23732813; 23815949; 23967336; 24273934; 24600982
description: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
database cross reference: Ensembl:ENSG00000163739
database cross reference: HGNC:4602
database cross reference: HPRD:01119
database cross reference: MIM:155730
database cross reference: Vega:OTTHUMG00000160866

GSK3A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GSK3A
full name from nomenclature authority: glycogen synthase kinase 3 alpha
NCBI GeneID: 2931
gene map location: 19q13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003073 (EC: ISS); GO_0003214 (EC: ISS); GO_0004674 (EC: IDA, PMID: 11035810); GO_0005515 (EC: IPI, PMID: 16365045); GO_0005524 (EC: IEA); GO_0005829 (EC: TAS, PMID: 11035810); GO_0005977 (EC: IEA); GO_0006468 (EC: IDA, PMID: 11035810); GO_0006987 (EC: TAS); GO_0007173 (EC: TAS); GO_0007399 (EC: IEA); GO_0008286 (EC: ISS, PMID: 18285345); GO_0008543 (EC: TAS); GO_0010905 (EC: IC, PMID: 11035810); GO_0016055 (EC: IEA); GO_0030819 (EC: ISS); GO_0030877 (EC: NAS, PMID: 19759537); GO_0030877 (EC: TAS, PMID: 19366350); GO_0030968 (EC: TAS); GO_0032007 (EC: ISS); GO_0032869 (EC: IMP, PMID: 17569761); GO_0034236 (EC: IPI, PMID: 11035810); GO_0036016 (EC: ISS); GO_0038095 (EC: TAS); GO_0043161 (EC: ISS); GO_0044267 (EC: TAS); GO_0045087 (EC: TAS); GO_0045719 (EC: TAS, PMID: 19366350); GO_0045732 (EC: NAS, PMID: 19759537); GO_0045823 (EC: ISS); GO_0046325 (EC: IMP, PMID: 17569761); GO_0046627 (EC: IMP, PMID: 17569761); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0050321 (EC: TAS, PMID: 19366350); GO_0051348 (EC: IMP, PMID: 17569761); GO_0061052 (EC: ISS); GO_0071879 (EC: ISS); GO_0090090 (EC: TAS, PMID: 19366350); GO_0097192 (EC: ISS); GO_1901030 (EC: ISS); GO_2000077 (EC: TAS, PMID: 19366350); GO_2000466 (EC: TAS, PMID: 19366350); GO_2000467 (EC: ISS)
has PubMed association: PMID: 7706316; 7715701; 7931292; 8404858; 8524413; 8725894; 9468292; 9735171; 9809441; 10448973; 11035810; 11481324; 11500362; 11509608; 11749387; 11884598; 12054501; 12086949; 12379450; 12477932; 12665592; 12675919; 12761548; 12890758; 14550568; 14563837; 14635195; 14645548; 15057824; 15194499; 15302935; 15324660; 15361837; 15469820; 15489334; 15592455; 15631989; 15678105; 16365045; 16371461; 16446437; 16537926; 16543145; 16543730; 16611631; 16757548; 16806170; 16912034; 16934436; 16984735; 16987514; 17052453; 17139249; 17158447; 17192257; 17325032; 17505062; 17569761; 17609434; 18042454; 18285345; 18450971; 18500637; 18516299; 18826950; 18829575; 18955053; 19131971; 19136008; 19142874; 19156168; 19323791; 19336475; 19366350; 19464003; 19507191; 19656851; 19705135; 19706605; 19759537; 19995607; 20080974; 20113358; 20368287; 20371704; 20541704; 20668436; 20831597; 20920357; 21139048; 21220517; 21255011; 21320285; 21436692; 21576335; 21718540; 21775285; 21890473; 21896753; 22022450; 22065737; 22326953; 22328534; 22384031; 22505724; 22539113; 22539723; 22658458; 22939624; 23000965; 23192081; 23243017; 23352529; 23369789; 23602568; 23621307; 23798682; 23959799
description: glycogen synthase kinase 3 alpha

GSK3B
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GSK3B
full name from nomenclature authority: glycogen synthase kinase 3 beta
NCBI GeneID: 2932
gene map location: 3q13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000320 (EC: IEA); GO_0001085 (EC: IPI); GO_0001837 (EC: IMP, PMID: 15448698); GO_0001954 (EC: IMP, PMID: 18156211); GO_0002039 (EC: IDA, PMID: 14744935); GO_0004674 (EC: IDA, PMID: 11035810); GO_0004674 (EC: ISS); GO_0005178 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11004522); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005737 (EC: IDA, PMID: 14744935); GO_0005813 (EC: IDA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA); GO_0005977 (EC: IDA, PMID: 8638126); GO_0006349 (EC: IEA); GO_0006468 (EC: IDA, PMID: 11035810); GO_0006611 (EC: IEA); GO_0006983 (EC: IDA, PMID: 14744935); GO_0007173 (EC: TAS); GO_0007411 (EC: TAS); GO_0007520 (EC: IEA); GO_0007623 (EC: ISS); GO_0008013 (EC: IPI, PMID: 8638126); GO_0008543 (EC: TAS); GO_0009887 (EC: IEA); GO_0010226 (EC: IEA); GO_0010614 (EC: IEA); GO_0010800 (EC: IEA); GO_0016301 (EC: IDA, PMID: 15448698); GO_0016301 (EC: TAS); GO_0016477 (EC: IEA); GO_0018105 (EC: IDA, PMID: 11104755); GO_0019901 (EC: IPI, PMID: 18348280); GO_0021766 (EC: IMP, PMID: 19581563); GO_0030010 (EC: IEA); GO_0030426 (EC: IEA); GO_0030529 (EC: IEA); GO_0030877 (EC: IDA, PMID: 16188939); GO_0030877 (EC: TAS, PMID: 19366350); GO_0031333 (EC: IMP, PMID: 16188939); GO_0031334 (EC: IDA, PMID: 8638126); GO_0031625 (EC: IPI); GO_0032091 (EC: IDA, PMID: 16890161); GO_0032092 (EC: ISS); GO_0032855 (EC: IMP, PMID: 18156211); GO_0032886 (EC: IMP); GO_0033138 (EC: IEA); GO_0034236 (EC: IPI, PMID: 11035810); GO_0035255 (EC: IEA); GO_0035372 (EC: IEA); GO_0035556 (EC: IDA, PMID: 14749367); GO_0036016 (EC: ISS); GO_0038095 (EC: TAS); GO_0042493 (EC: IEA); GO_0043025 (EC: IEA); GO_0043066 (EC: IDA, PMID: 14744935); GO_0043197 (EC: IEA); GO_0043198 (EC: IEA); GO_0043407 (EC: IEA); GO_0044027 (EC: IEA); GO_0044337 (EC: IEA); GO_0045087 (EC: TAS); GO_0045121 (EC: IEA); GO_0045444 (EC: IEA); GO_0045719 (EC: TAS, PMID: 19366350); GO_0045732 (EC: IC, PMID: 16188939); GO_0045944 (EC: IEA); GO_0046827 (EC: IDA, PMID: 14744935); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0…
has PubMed association: PMID: 1181841; 1324914; 1330687; 1333807; 6772446; 7514173; 7566346; 7642555; 7706316; 7980435; 8247524; 8382613; 8404858; 8524413; 8638126; 8764598; 8861947; 8889548; 8999860; 9072970; 9199504; 9271238; 9353289; 9468292; 9482734; 9546672; 9565682; 9566905; 9570753; 9601641; 9731200; 9734785; 9735171; 9736715; 9771888; 9809441; 9819408; 9832145; 9832503; 10074433; 10090741; 10228155; 10330181; 10330403; 10347142; 10428053; 10428961; 10486203; 10488109; 10523816; 10567568; 10581160; 10587587; 10653665; 10671552; 10753899; 10826493; 10910956; 10936190; 10966653; 11004522; 11035810; 11104755; 11152665; 11166179; 11181841; 11251183; 11311121; 11320080; 11425860; 11427888; 11440715; 11481324; 11483158; 11495916; 11500362; 11524435; 11738041; 11781156; 11809746; 11812770; 11818547; 11835406; 11877389; 11903055; 11955436; 11967263; 11980723; 11986994; 12000790; 12048243; 12051714; 12054501; 12063245; 12064478; 12086949; 12095675; 12114015; 12123574; 12130654; 12133000; 12147701; 12162494; 12167628; 12182887; 12183362; 12226093; 12228224; 12244165; 12364325; 12376533; 12379450; 12387894; 12387897; 12417018; 12434148; 12477932; 12511557; 12527198; 12554650; 12566926; 12584189; 12603528; 12663502; 12761178; 12778079; 12794074; 12796505; 12808104; 12819195; 12820959; 12829841; 12871932; 12885254; 12900420; 12927815; 12969793; 14518171; 14520463; 14523002; 14536078; 14550568; 14561750; 14563837; 14612456; 14617795; 14635195; 14636947; 14645548; 14660640; 14690523; 14691449; 14729058; 14729229; 14744935; 14749367; 14985354; 14988008; 14988390; 14991743; 15020233; 15026145; 15073173; 15132987; 15147888; 15178331; 15178691; 15179015; 15231747; 15252116; 15254796; 15302935; 15327769; 15345747; 15351432; 15361837; 15375789; 15379854; 15383283; 15448698; 15456937; 15465828; 15469820; 15470047; 15489334; 15517997; 15522877; 15555766; 15592455; 15609321; 15631989; 15647282; 15652488; 15678105; 15688030; 15719395; 15752768; 15799972; 15824731; 15829978; 15940626; 15942663; 15951569; 159…
description: glycogen synthase kinase 3 beta

GSR
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HEL-75
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GSR
full name from nomenclature authority: glutathione reductase
NCBI GeneID: 2936
gene map location: 8p21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004362 (EC: TAS); GO_0005759 (EC: TAS); GO_0005829 (EC: TAS); GO_0006749 (EC: IEA); GO_0009055 (EC: TAS, PMID: 947404); GO_0015949 (EC: TAS); GO_0044281 (EC: TAS); GO_0045454 (EC: IEA); GO_0050660 (EC: IEA); GO_0050661 (EC: IEA); GO_0055086 (EC: TAS); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 302667; 923580; 947404; 2185014; 2306116; 2379581; 3656429; 6822532; 7060551; 7334521; 7663973; 8626496; 8889548; 9151953; 9174360; 9546215; 10708558; 11204445; 11273669; 11710935; 12095224; 12447480; 12477932; 12516882; 12533953; 12630007; 12826156; 12838767; 12838770; 12901426; 14637279; 15149466; 15489334; 15592455; 15978628; 16009940; 16169070; 16236267; 16341674; 16421571; 16424062; 16868544; 17185460; 17206382; 17601350; 18341267; 18638483; 18977241; 19056867; 19124506; 19322201; 19377255; 19527700; 19560448; 19806191; 19896490; 19913121; 20200426; 20379614; 20485444; 20586645; 20628086; 20628807; 20877624; 21139048; 21417634; 21890473; 21906983; 21988832; 22089180; 22863883; 22939629; 22944692; 23000965; 23637325; 23770363; 24250222
description: glutathione reductase
database cross reference: Ensembl:ENSG00000104687
database cross reference: HGNC:4623
database cross reference: HPRD:00704
database cross reference: MIM:138300
database cross reference: Vega:OTTHUMG00000163946

GYS1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GSY
alternative term: GYS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GYS1
full name from nomenclature authority: glycogen synthase 1 (muscle)
NCBI GeneID: 2997
gene map location: 19q13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004373 (EC: EXP); GO_0004373 (EC: IDA, PMID: 16275910); GO_0005515 (EC: IPI, PMID: 16189514); GO_0005536 (EC: IEA); GO_0005829 (EC: TAS); GO_0005975 (EC: TAS); GO_0005978 (EC: IDA, PMID: 16275910); GO_0005978 (EC: IEA); GO_0005978 (EC: TAS); GO_0006006 (EC: TAS); GO_0007507 (EC: IEA); GO_0016234 (EC: IEA); GO_0019901 (EC: IPI, PMID: 16275910); GO_0044281 (EC: TAS); GO_0061547 (EC: EXP)
has PubMed association: PMID: 2117608; 2493642; 6772446; 7631777; 7657035; 8062946; 8125298; 8280084; 8449521; 9010351; 9346895; 9628874; 10924520; 11092303; 11147787; 11251056; 11427888; 12411100; 12477932; 12732844; 12870167; 15194499; 15282316; 15342556; 15489334; 15855312; 15955076; 16115820; 16189514; 16275910; 16282323; 17055998; 17137217; 17353931; 17356695; 17928598; 18544618; 18996102; 19339242; 19420105; 19578796; 19615732; 19773279; 19837931; 19913121; 20017397; 20300197; 20384434; 20562859; 20602615; 20628086; 21139048; 21145461; 21832049; 21890473; 21906983; 21963094; 21985244; 21987572; 22403297; 22505724; 22952844; 23000965; 23134486; 23321478; 24049095
description: glycogen synthase 1 (muscle)
database cross reference: Ensembl:ENSG00000104812
database cross reference: HGNC:4706
database cross reference: HPRD:00721
database cross reference: MIM:138570
database cross reference: Vega:OTTHUMG00000150723

HSD17B10
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: 17b-HSD10
alternative term: ABAD
alternative term: CAMR
alternative term: DUPXp11.22
alternative term: ERAB
alternative term: HADH2
alternative term: HCD2
alternative term: MHBD
alternative term: MRPP2
alternative term: MRX17
alternative term: MRX31
alternative term: MRXS10
alternative term: SCHAD
alternative term: SDR5C1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HSD17B10
full name from nomenclature authority: hydroxysteroid (17-beta) dehydrogenase 10
NCBI GeneID: 3028
NCBI LocusTag: RP3-339A18.2
gene map location: Xp11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003857 (EC: EXP); GO_0005515 (EC: IPI, PMID: 18984158); GO_0005737 (EC: TAS, PMID: 9338779); GO_0005739 (EC: ISS); GO_0005743 (EC: IEA); GO_0005759 (EC: TAS); GO_0005783 (EC: IEA); GO_0005886 (EC: TAS, PMID: 9338779); GO_0006629 (EC: TAS, PMID: 9338779); GO_0008033 (EC: IEA); GO_0008709 (EC: TAS, PMID: 9338779); GO_0009083 (EC: TAS); GO_0030283 (EC: IEA); GO_0034641 (EC: TAS); GO_0044281 (EC: TAS); GO_0044822 (EC: IDA); GO_0047015 (EC: IEA)
has PubMed association: PMID: 8687463; 9061028; 9338779; 9553139; 9671743; 9712734; 9851691; 9890977; 10329704; 10371197; 10600649; 11403151; 11430884; 11559359; 11869808; 12477932; 12696021; 12917011; 14672739; 15087549; 15342248; 15489334; 15665036; 15804423; 16021519; 16148061; 16176262; 16344560; 16899120; 17236142; 17266347; 17500595; 17618155; 17707551; 17917077; 18252223; 18692800; 18765932; 18984158; 19027726; 19343046; 19422801; 19449377; 19601895; 19706438; 19735314; 19738201; 19756307; 20000738; 20059664; 20077426; 20186120; 20638476; 20664630; 21081666; 21139048; 21145461; 21382475; 21890473; 21900206; 21906983; 21907836; 22127393; 22174920; 22217844; 22623428; 22863883; 22939629; 23000965; 23266819; 23667531; 23755257; 23834306
description: hydroxysteroid (17-beta) dehydrogenase 10
database cross reference: Ensembl:ENSG00000072506
database cross reference: HGNC:4800
database cross reference: HPRD:02223
database cross reference: MIM:300256
database cross reference: Vega:OTTHUMG00000021612

HTT
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HD
alternative term: IT15
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HTT
full name from nomenclature authority: huntingtin
NCBI GeneID: 3064
gene map location: 4p16.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000050 (EC: IEA); GO_0000052 (EC: IEA); GO_0000132 (EC: IMP); GO_0002039 (EC: IPI, PMID: 10823891); GO_0005515 (EC: IPI, PMID: 10823891); GO_0005634 (EC: IDA, PMID: 12783847); GO_0005737 (EC: IDA, PMID: 15064418); GO_0005739 (EC: IEA); GO_0005770 (EC: IDA, PMID: 17704510); GO_0005776 (EC: IDA, PMID: 17704510); GO_0005783 (EC: IDA, PMID: 17704510); GO_0005794 (EC: IDA, PMID: 15837803); GO_0005829 (EC: IDA); GO_0006606 (EC: IEA); GO_0006888 (EC: IEA); GO_0006890 (EC: IMP); GO_0007029 (EC: IEA); GO_0007030 (EC: IMP); GO_0007212 (EC: IEA); GO_0007283 (EC: IEA); GO_0007569 (EC: IEA); GO_0007625 (EC: IEA); GO_0007626 (EC: IEA); GO_0008088 (EC: IEA); GO_0008134 (EC: IBA); GO_0008340 (EC: IEA); GO_0008542 (EC: IEA); GO_0009952 (EC: IEA); GO_0016197 (EC: IEA); GO_0016234 (EC: IEA); GO_0019244 (EC: IEA); GO_0019805 (EC: IEA); GO_0021756 (EC: IEA); GO_0021988 (EC: IEA); GO_0021990 (EC: IEA); GO_0030073 (EC: IEA); GO_0030424 (EC: IDA, PMID: 7748555); GO_0030425 (EC: IDA, PMID: 7748555); GO_0030659 (EC: IDA, PMID: 7748555); GO_0034047 (EC: IMP); GO_0034452 (EC: IPI, PMID: 18922795); GO_0035176 (EC: IEA); GO_0042445 (EC: IEA); GO_0042802 (EC: IPI); GO_0043234 (EC: IDA, PMID: 18922795); GO_0043524 (EC: IEA); GO_0045505 (EC: IDA); GO_0046825 (EC: IMP, PMID: 15654337); GO_0046902 (EC: IEA); GO_0047496 (EC: IMP); GO_0048167 (EC: IEA); GO_0048341 (EC: IEA); GO_0048487 (EC: IDA, PMID: 11870213); GO_0048513 (EC: IBA); GO_0048666 (EC: IEA); GO_0050809 (EC: IEA); GO_0051402 (EC: IEA); GO_0051592 (EC: IEA); GO_0051881 (EC: IEA); GO_0051938 (EC: IEA); GO_0055072 (EC: IEA); GO_2001237 (EC: IMP, PMID: 19240112)
has PubMed association: PMID: 1302016; 7477378; 7568002; 7647777; 7748555; 7759106; 7774020; 7903579; 7951324; 8162057; 8197474; 8458085; 8612237; 8696339; 8702625; 9079622; 9147654; 9152833; 9454836; 9466992; 9535906; 9599014; 9668110; 9700202; 9778247; 9809064; 10332029; 10353249; 10410676; 10434301; 10441327; 10770929; 10801775; 10823891; 10958656; 10974549; 11008591; 11013077; 11035034; 11063258; 11092755; 11105061; 11121205; 11137014; 11149616; 11172033; 11264541; 11319238; 11379408; 11432963; 11442349; 11461154; 11468270; 11487199; 11595021; 11607033; 11642542; 11738012; 11739372; 11745989; 11788820; 11792860; 11807410; 11839795; 11854752; 11870213; 11906693; 11939977; 11971872; 11973620; 11988536; 12062094; 12135980; 12191472; 12204002; 12354289; 12354780; 12379151; 12393306; 12393793; 12417652; 12427879; 12456676; 12466534; 12477932; 12548366; 12555240; 12569151; 12604778; 12657678; 12682342; 12783847; 12784292; 12799135; 12807877; 12810713; 12824708; 12873381; 12881483; 12881722; 12952868; 12956863; 14527999; 14570710; 14570907; 14572927; 14617779; 14657499; 14713958; 14714490; 14743370; 14978262; 14985437; 15032971; 15064418; 15140195; 15140196; 15163634; 15225551; 15240759; 15261377; 15273431; 15312898; 15316797; 15338298; 15340079; 15351733; 15359012; 15371500; 15383276; 15468075; 15496672; 15603740; 15610167; 15654337; 15689617; 15716522; 15717026; 15809304; 15815621; 15832309; 15837803; 15843398; 15890517; 15911879; 15916486; 15936278; 15951191; 15994095; 15996546; 16006135; 16085648; 16091361; 16115810; 16115812; 16162412; 16169070; 16183657; 16192271; 16204350; 16278683; 16286508; 16324236; 16365166; 16391387; 16417581; 16452635; 16456924; 16473015; 16492755; 16522639; 16595690; 16606912; 16729030; 16777606; 16782707; 16835690; 16968735; 16973623; 17012230; 17098699; 17115386; 17124493; 17126554; 17135277; 17141218; 17151278; 17161366; 17189290; 17201528; 17208201; 17240517; 17276991; 17299753; 17361007; 17403029; 17409200; 17433700; 17500595; 17519223; 17548833; 17603015; …
description: huntingtin
database cross reference: Ensembl:ENSG00000197386
database cross reference: HGNC:4851
database cross reference: HPRD:00883
database cross reference: MIM:613004
database cross reference: Vega:OTTHUMG00000159916

NRG1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ARIA
alternative term: GGF
alternative term: GGF2
alternative term: HGL
alternative term: HRG
alternative term: HRG1
alternative term: HRGA
alternative term: MST131
alternative term: NDF
alternative term: SMDF
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NRG1
full name from nomenclature authority: neuregulin 1
NCBI GeneID: 3084
gene map location: 8p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: IEA); GO_0000902 (EC: IEA); GO_0003161 (EC: IEA); GO_0003222 (EC: IDA, PMID: 17336907); GO_0003712 (EC: IDA, PMID: 15073182); GO_0005102 (EC: IPI, PMID: 7514177); GO_0005125 (EC: TAS, PMID: 10372964); GO_0005176 (EC: IEA); GO_0005515 (EC: IPI, PMID: 7592681); GO_0005576 (EC: NAS, PMID: 1348215); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 11389077); GO_0005634 (EC: IEA); GO_0005737 (EC: IEA); GO_0005887 (EC: IEA); GO_0007154 (EC: TAS, PMID: 17432114); GO_0007169 (EC: IDA, PMID: 7514177); GO_0007171 (EC: IDA, PMID: 9553078); GO_0007171 (EC: NAS, PMID: 1348215); GO_0007173 (EC: TAS); GO_0007399 (EC: TAS, PMID: 17432114); GO_0007416 (EC: IEA); GO_0007422 (EC: IEA); GO_0007626 (EC: IEA); GO_0008083 (EC: IDA, PMID: 11389077); GO_0008083 (EC: NAS, PMID: 8096067); GO_0008283 (EC: IDA, PMID: 11389077); GO_0008543 (EC: TAS); GO_0009790 (EC: IEA); GO_0010667 (EC: IDA, PMID: 9553078); GO_0014032 (EC: TAS, PMID: 17432114); GO_0016020 (EC: NAS, PMID: 8096067); GO_0016324 (EC: IDA, PMID: 12646923); GO_0016477 (EC: IEA); GO_0021781 (EC: IEA); GO_0030296 (EC: IDA, PMID: 7556068); GO_0030297 (EC: IC, PMID: 9553078); GO_0030297 (EC: NAS, PMID: 1348215); GO_0030307 (EC: IDA, PMID: 9553078); GO_0030424 (EC: IEA); GO_0030879 (EC: TAS, PMID: 17432114); GO_0030971 (EC: NAS, PMID: 1348215); GO_0031594 (EC: IEA); GO_0038095 (EC: TAS); GO_0038127 (EC: IDA, PMID: 11389077); GO_0042060 (EC: IDA, PMID: 12646923); GO_0042060 (EC: TAS, PMID: 16412517); GO_0042177 (EC: IEA); GO_0043125 (EC: IDA, PMID: 7556068); GO_0043125 (EC: IPI, PMID: 11389077); GO_0043496 (EC: TAS, PMID: 16412517); GO_0043497 (EC: IDA, PMID: 10559227); GO_0043624 (EC: IGI, PMID: 15155732); GO_0045087 (EC: TAS); GO_0045213 (EC: IEA); GO_0045785 (EC: IDA, PMID: 7556068); GO_0045892 (EC: IDA, PMID: 15073182); GO_0046579 (EC: IEA); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0048663 (EC: IEA); GO_0051048 (EC: IDA, PMID: 10559227); GO_0051155 (EC: ISS); GO_0051897 (EC: IEA); GO_0055007 (EC: ISS); GO_0055012 …
has PubMed association: PMID: 1348215; 1350381; 7509448; 7514177; 7556068; 7592681; 7689552; 7721889; 7730382; 7782315; 7876250; 7903175; 8062828; 8095334; 8096067; 8125298; 8325659; 8702572; 9168114; 9168115; 9333014; 9342050; 9553078; 9565587; 9685409; 10372964; 10523851; 10537356; 10559227; 10585499; 10597312; 11116142; 11389077; 11555649; 11896060; 12082616; 12145742; 12204892; 12471041; 12477932; 12478479; 12509456; 12528817; 12556556; 12600989; 12646923; 12768307; 12800145; 12808428; 12874607; 14569272; 14632199; 14647391; 14699424; 14702039; 14729827; 14966480; 15007393; 15073182; 15155732; 15159416; 15162166; 15197397; 15219675; 15248869; 15276238; 15303101; 15326116; 15466169; 15489334; 15494726; 15498868; 15527969; 15538186; 15545978; 15584912; 15609326; 15645137; 15703820; 15897877; 15939841; 16082692; 16155362; 16158055; 16189508; 16219117; 16219118; 16249994; 16287046; 16326006; 16344560; 16412517; 16428439; 16442083; 16446404; 16470843; 16483744; 16520822; 16526041; 16618933; 16638076; 16687441; 16690615; 16730337; 16767099; 16825199; 16867224; 16868568; 16891421; 16940976; 17033632; 17072305; 17214955; 17275115; 17300918; 17336907; 17336946; 17366345; 17405926; 17408693; 17432114; 17447867; 17499242; 17503451; 17519028; 17562386; 17565985; 17598910; 17602072; 17631867; 17652086; 17884806; 17901998; 17903296; 17925794; 17941827; 17962208; 18032396; 18159252; 18180429; 18193072; 18198266; 18234478; 18255317; 18282690; 18286587; 18291420; 18395550; 18455303; 18455369; 18466879; 18466881; 18470533; 18494263; 18494554; 18497096; 18516516; 18543275; 18571900; 18583979; 18584117; 18585932; 18606232; 18668031; 18704261; 18714568; 18728681; 18798975; 18799465; 18806920; 19054571; 19058791; 19086053; 19127563; 19148499; 19150438; 19156152; 19184335; 19196962; 19199244; 19229203; 19269083; 19306381; 19328558; 19339916; 19350564; 19367581; 19367584; 19394386; 19439994; 19448847; 19449332; 19497323; 19521112; 19545856; 19556605; 19569180; 19573260; 19575259; 19594860; 19597049; 19626024;…
description: neuregulin 1
database cross reference: Ensembl:ENSG00000157168
database cross reference: HGNC:7997
database cross reference: HPRD:00802
database cross reference: MIM:142445
database cross reference: Vega:OTTHUMG00000163918

HIF1A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HIF-1A
alternative term: HIF-1alpha
alternative term: HIF1
alternative term: HIF1-ALPHA
alternative term: MOP1
alternative term: PASD8
alternative term: bHLHe78
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HIF1A
full name from nomenclature authority: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
NCBI GeneID: 3091
gene map location: 14q23.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 14
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000989 (EC: IDA); GO_0001076 (EC: IEA); GO_0001077 (EC: IEA); GO_0001525 (EC: IEA); GO_0001666 (EC: IDA, PMID: 11782478); GO_0001666 (EC: IMP, PMID: 12411310); GO_0001755 (EC: IEA); GO_0001837 (EC: ISS, PMID: 18037992); GO_0001892 (EC: IEA); GO_0001922 (EC: IEA); GO_0001938 (EC: IC, PMID: 8756616); GO_0001947 (EC: IEA); GO_0002052 (EC: IEA); GO_0002248 (EC: ISS, PMID: 18037992); GO_0003151 (EC: IEA); GO_0003208 (EC: IEA); GO_0003700 (EC: IDA, PMID: 11782478); GO_0003700 (EC: TAS, PMID: 15261140); GO_0003705 (EC: IDA, PMID: 8387214); GO_0003705 (EC: IDA, Qualifier: contributes_to, PMID: 7539918); GO_0004871 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12004076); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005667 (EC: IPI, PMID: 9576906); GO_0005730 (EC: IDA); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0006089 (EC: IEA); GO_0006355 (EC: IDA, PMID: 11782478); GO_0006879 (EC: IEA); GO_0007165 (EC: IMP, PMID: 12411310); GO_0007219 (EC: TAS); GO_0007595 (EC: IEA); GO_0008134 (EC: IPI, PMID: 7539918); GO_0008542 (EC: IEA); GO_0010468 (EC: IDA, PMID: 18419598); GO_0010573 (EC: IDA, PMID: 12958148); GO_0010575 (EC: IDA, PMID: 8756616); GO_0010575 (EC: IMP, PMID: 18658046); GO_0010634 (EC: ISS, PMID: 18037992); GO_0010870 (EC: IMP, PMID: 17178876); GO_0014850 (EC: IEA); GO_0019896 (EC: IMP, PMID: 19528298); GO_0019899 (EC: IPI, PMID: 11641274); GO_0019901 (EC: IPI); GO_0021502 (EC: IEA); GO_0021987 (EC: IEA); GO_0030502 (EC: IEA); GO_0030949 (EC: IC, PMID: 12958148); GO_0031514 (EC: IEA); GO_0031625 (EC: IPI, PMID: 11641274); GO_0032007 (EC: IEA); GO_0032364 (EC: IDA, PMID: 16956324); GO_0032722 (EC: TAS, PMID: 18370914); GO_0032909 (EC: IMP, PMID: 12411310); GO_0032963 (EC: ISS, PMID: 18037992); GO_0035035 (EC: IPI, PMID: 15261140); GO_0035162 (EC: IEA); GO_0035257 (EC: IPI, PMID: 18658046); GO_0035774 (EC: IEA); GO_0042541 (EC: IEA); GO_0042593 (EC: IEA); GO_0042789 (EC: IC, PMID: 7539918); GO_0042826 (EC: IEA); GO_0043524 (EC: IEA); GO_0043565 (EC: IDA, Qualifier: con…
has PubMed association: PMID: 1448077; 7539918; 7836384; 8089148; 8107114; 8387214; 8663540; 8753788; 8756616; 8786149; 8816435; 8927054; 9079689; 9235919; 9537326; 9576906; 9653127; 9704006; 9782081; 9822602; 9828130; 9887100; 9923855; 10202154; 10353251; 10425220; 10551817; 10594042; 10640274; 10702253; 10758161; 10777486; 10823831; 10878807; 10903152; 10906065; 10944113; 10950862; 10961998; 10973499; 11006129; 11024059; 11089639; 11226425; 11278891; 11292861; 11292862; 11331613; 11358837; 11382768; 11389899; 11486006; 11504942; 11566883; 11573933; 11593383; 11598268; 11641274; 11707426; 11726537; 11734856; 11739718; 11782478; 11823643; 11852072; 11861398; 11865071; 11868612; 11886167; 11940656; 11943784; 11959977; 11959990; 11971899; 11980639; 11986208; 11992540; 12004076; 12016145; 12042299; 12050673; 12062197; 12080085; 12084725; 12086861; 12099689; 12114320; 12123724; 12124396; 12136249; 12149254; 12154057; 12202863; 12205091; 12207089; 12209691; 12213597; 12213806; 12215445; 12228247; 12237125; 12239177; 12242281; 12296651; 12351678; 12376345; 12401798; 12411310; 12446723; 12451989; 12464182; 12468553; 12477932; 12482756; 12482858; 12485908; 12485909; 12488445; 12538644; 12560087; 12586627; 12586829; 12588875; 12606543; 12606552; 12632503; 12651620; 12670503; 12673675; 12682018; 12697836; 12727858; 12743597; 12761217; 12764143; 12778114; 12781449; 12808024; 12810083; 12821113; 12823854; 12855680; 12858534; 12865501; 12871382; 12876287; 12883692; 12885785; 12900407; 12912907; 12914933; 12914934; 12919954; 12925778; 12937141; 12944107; 12958148; 12966423; 14512791; 14521712; 14523474; 14556007; 14559790; 14600153; 14636255; 14638687; 14645546; 14657004; 14662854; 14671307; 14672622; 14680803; 14680833; 14681237; 14691445; 14699081; 14702039; 14712484; 14726529; 14729605; 14734545; 14742449; 14744756; 14744852; 14757845; 14981919; 15024076; 15024078; 15031145; 15060148; 15062033; 15064771; 15071503; 15082527; 15082785; 15084243; 15084514; 15111179; 15135259; 15135470; 15146197; 1514797…
description: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
database cross reference: Ensembl:ENSG00000100644
database cross reference: HGNC:4910
database cross reference: HPRD:04517
database cross reference: MIM:603348
database cross reference: Vega:OTTHUMG00000140344

HLA-DRB5
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HLA-DRB
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HLA-DRB5
full name from nomenclature authority: major histocompatibility complex, class II, DR beta 5
NCBI GeneID: 3127
NCBI LocusTag: hCG_1998957
gene map location: 6p21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: TAS); GO_0002381 (EC: ISS); GO_0002437 (EC: ISS); GO_0002455 (EC: ISS); GO_0005765 (EC: IDA, PMID: 18305173); GO_0005765 (EC: TAS); GO_0005886 (EC: TAS); GO_0006955 (EC: ISS); GO_0009897 (EC: ISS); GO_0012507 (EC: TAS); GO_0016045 (EC: ISS); GO_0019221 (EC: TAS); GO_0019886 (EC: TAS); GO_0030658 (EC: TAS); GO_0030666 (EC: TAS); GO_0030669 (EC: TAS); GO_0031295 (EC: TAS); GO_0031902 (EC: IDA, PMID: 18305173); GO_0032588 (EC: TAS); GO_0032673 (EC: ISS); GO_0032689 (EC: ISS); GO_0035774 (EC: ISS); GO_0042088 (EC: ISS); GO_0042130 (EC: ISS); GO_0042605 (EC: ISS); GO_0042613 (EC: IEA); GO_0050852 (EC: TAS); GO_0051262 (EC: ISS); GO_0060333 (EC: TAS); GO_0070062 (EC: IDA, PMID: 12519789); GO_0071556 (EC: TAS); GO_2001179 (EC: ISS)
has PubMed association: PMID: 1428007; 1612646; 1869305; 1905983; 1967269; 1970352; 1975801; 1978941; 2023919; 2212675; 2471740; 2511168; 2543930; 2565895; 2846691; 2884201; 2885840; 3015788; 3020127; 3099214; 3129499; 3137159; 3259543; 3371836; 3456344; 3466180; 3476943; 3489470; 3571980; 7512597; 7541827; 7547576; 7602119; 7645219; 7652736; 7734415; 7974469; 8016840; 8026992; 8084338; 8168144; 8168862; 8362413; 8376762; 8450224; 8462990; 8655358; 8864175; 8988548; 9027973; 9079699; 9162096; 9223324; 9226128; 9349614; 9500545; 9777332; 9820607; 9864034; 10551425; 10609818; 10661406; 10703621; 10729169; 11034591; 11048639; 11082515; 11082517; 11118314; 11144300; 11169266; 11181188; 11181995; 11260517; 11380955; 11469465; 11555411; 11704801; 11751963; 11782380; 11798795; 11827988; 11934390; 11972886; 11997714; 12028548; 12121280; 12133402; 12144077; 12144632; 12202216; 12209103; 12230470; 12244309; 12296785; 12358860; 12392858; 12427289; 12477932; 12519789; 12652907; 12694574; 12694577; 12956878; 14508706; 14617041; 14752708; 14989721; 15191532; 15191533; 15245378; 15489916; 15730527; 15784911; 15896200; 15902698; 15982265; 16140993; 16305688; 16405603; 16426242; 16441501; 16566202; 16916662; 16973583; 17106278; 17153701; 17182961; 17207965; 17411376; 17431094; 17507489; 17559577; 17652306; 17910142; 17959659; 18305173; 18520346; 18569076; 18672082; 18713991; 18832704; 18846964; 18945465; 19116923; 19122664; 19223392; 19235017; 19380721; 19449444; 19620308; 19663932; 19770068; 19811438; 20012522; 20193235; 20193583; 20307907; 20394989; 20458337; 20606439; 20639878; 21085635; 21131588; 21297633; 21299892; 21778700; 21906983; 21922073; 22033527; 22493691; 22531795; 22723597; 22808111; 22860026; 22862923; 22888134; 23349640; 23535732; 23850713
description: major histocompatibility complex, class II, DR beta 5
database cross reference: Ensembl:ENSG00000198502
database cross reference: HGNC:4953
database cross reference: HPRD:09209
database cross reference: MIM:604776
database cross reference: Vega:OTTHUMG00000031027

HMGB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HMG1
alternative term: HMG3
alternative term: SBP-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HMGB1
full name from nomenclature authority: high mobility group box 1
NCBI GeneID: 3146
NCBI LocusTag: RP11-550P23.1
gene map location: 13q12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 13
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IMP, PMID: 19158276); GO_0000793 (EC: IDA, PMID: 12925773); GO_0001773 (EC: ISS); GO_0002407 (EC: ISS); GO_0002437 (EC: IEP, PMID: 19841752); GO_0003684 (EC: ISS); GO_0003690 (EC: ISS); GO_0003697 (EC: ISS); GO_0003700 (EC: IDA, PMID: 19223331); GO_0005125 (EC: ISS); GO_0005515 (EC: IPI, PMID: 11748232); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 19841752); GO_0005634 (EC: IDA, PMID: 19223331); GO_0005654 (EC: TAS); GO_0006265 (EC: ISS); GO_0006288 (EC: IDA, PMID: 9600082); GO_0006309 (EC: TAS); GO_0006310 (EC: ISS); GO_0006357 (EC: IDA, PMID: 11748232); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0008134 (EC: IPI, PMID: 19223331); GO_0008301 (EC: IMP, PMID: 19223331); GO_0008301 (EC: ISS); GO_0009986 (EC: IDA, PMID: 19841752); GO_0017053 (EC: IDA, Qualifier: colocalizes_with, PMID: 19158276); GO_0017055 (EC: IDA, PMID: 8006019); GO_0031175 (EC: ISS); GO_0033151 (EC: IDA, PMID: 9166431); GO_0042056 (EC: ISS); GO_0043065 (EC: IDA, PMID: 19800306); GO_0043280 (EC: IDA, PMID: 19800306); GO_0043388 (EC: IDA, PMID: 11748232); GO_0044822 (EC: IDA); GO_0045087 (EC: TAS); GO_0045944 (EC: IDA, PMID: 19223331); GO_0050786 (EC: ISS); GO_0050918 (EC: ISS); GO_0051103 (EC: ISS); GO_0070491 (EC: IPI, PMID: 19223331); GO_2000426 (EC: IEA)
has PubMed association: PMID: 1909331; 2013279; 2922262; 3697355; 8006019; 8339930; 8366113; 8661151; 8890171; 9036861; 9150946; 9166431; 9472015; 9507007; 9600082; 9628821; 9671457; 9722660; 9812979; 9880542; 10490593; 10531386; 10617144; 10652254; 10962007; 11099378; 11106654; 11246022; 11279268; 11294645; 11299752; 11470162; 11748221; 11748232; 12062430; 12110890; 12149489; 12231511; 12384917; 12456506; 12477932; 12488489; 12517784; 12534345; 12565837; 12591939; 12604365; 12620891; 12665595; 12727838; 12759333; 12785009; 12799451; 12925773; 12935895; 14517071; 14532127; 14534709; 14702039; 14739282; 14999020; 15005629; 15014079; 15130941; 15146429; 15162419; 15201494; 15210788; 15488733; 15489334; 15496585; 15666359; 15733057; 15743787; 15766246; 15793304; 15802534; 15877951; 15915542; 15924431; 15944249; 15994314; 16040616; 16130169; 16169070; 16267105; 16282196; 16570276; 16697213; 16751357; 16802368; 16807371; 16855214; 16916647; 16951227; 16962095; 16966386; 16968820; 16997859; 16997939; 17035340; 17060403; 17142771; 17203009; 17218606; 17346334; 17403666; 17475879; 17502242; 17504981; 17597834; 17610420; 17617154; 17678959; 17895302; 17918013; 17936030; 17958791; 17975708; 17991152; 18029348; 18073062; 18076993; 18160415; 18239618; 18239742; 18250463; 18277058; 18288272; 18294942; 18317568; 18346273; 18354232; 18425372; 18431589; 18441281; 18569640; 18577209; 18599803; 18631454; 18644848; 18655026; 18670905; 18680137; 18682735; 18692049; 18707018; 18715162; 18720262; 18759291; 18768881; 18788635; 18799030; 18822317; 18825489; 18825712; 18846108; 18850631; 18854154; 18949384; 18952078; 18974890; 18984601; 18996119; 19005067; 19009026; 19044016; 19087540; 19139725; 19148477; 19150066; 19151394; 19158276; 19197071; 19201506; 19214652; 19223331; 19247800; 19387923; 19398086; 19417608; 19445369; 19446504; 19451748; 19471022; 19476625; 19505873; 19515846; 19530996; 19533845; 19545550; 19564572; 19571604; 19572890; 19616266; 19639200; 19666121; 19679874; 19726280; 19738201; 19751520; 1977…
description: high mobility group box 1
database cross reference: Ensembl:ENSG00000189403
database cross reference: HGNC:4983
database cross reference: HPRD:01228
database cross reference: MIM:163905
database cross reference: Vega:OTTHUMG00000016670

HMGCR
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LDLCQ3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HMGCR
full name from nomenclature authority: 3-hydroxy-3-methylglutaryl-CoA reductase
NCBI GeneID: 3156
gene map location: 5q13.3-q14
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004420 (EC: IEA); GO_0005515 (EC: IPI); GO_0005778 (EC: IDA, PMID: 17180682); GO_0005783 (EC: IDA, PMID: 17180682); GO_0005789 (EC: TAS, PMID: 2991281); GO_0006695 (EC: TAS); GO_0006743 (EC: IEA); GO_0007568 (EC: IEA); GO_0007584 (EC: IEA); GO_0008299 (EC: IEA); GO_0008542 (EC: IEA); GO_0009790 (EC: IEA); GO_0010664 (EC: IEA); GO_0010666 (EC: IEA); GO_0015936 (EC: IEA); GO_0016021 (EC: IEA); GO_0032874 (EC: IEA); GO_0042282 (EC: IDA, PMID: 2991281); GO_0042803 (EC: IEA); GO_0043407 (EC: IEA); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0045445 (EC: IEA); GO_0045471 (EC: IEA); GO_0045908 (EC: IEA); GO_0048643 (EC: IEA); GO_0048661 (EC: IEA); GO_0050662 (EC: IDA, PMID: 10698924); GO_0051262 (EC: IDA, PMID: 10698924); GO_0061045 (EC: IEA); GO_0061179 (EC: IEA); GO_0070374 (EC: IEA); GO_0070402 (EC: IDA, PMID: 10698924)
has PubMed association: PMID: 1755834; 1979742; 2369897; 2991281; 2998972; 3308873; 3860301; 3866240; 3896758; 6479432; 6491541; 8028508; 8406993; 9853754; 10391209; 10449533; 10695663; 10698924; 11349148; 11716764; 11894121; 12213890; 12477733; 12477932; 12535518; 12778445; 12803139; 12860252; 12871602; 14556080; 14563840; 14684825; 14697242; 15090540; 15146197; 15199031; 15233402; 15473258; 15489334; 15811249; 16014965; 16054061; 16168377; 16196087; 16515720; 16930778; 17180682; 17284348; 17502376; 17652086; 17681147; 17855807; 17870053; 18024962; 18056971; 18193044; 18261733; 18332269; 18354102; 18459144; 18559695; 18622260; 18660489; 18676680; 18787507; 18802019; 18815589; 18996102; 19053857; 19060906; 19060911; 19067673; 19088433; 19148283; 19170196; 19197348; 19327767; 19336370; 19446537; 19458199; 19460711; 19554360; 19558216; 19625176; 19667110; 19692168; 19773416; 19887822; 19906111; 19913121; 19923996; 19948975; 20031551; 20031582; 20031591; 20145341; 20167577; 20235787; 20388088; 20403997; 20409966; 20413733; 20450896; 20458442; 20540816; 20571754; 20578904; 20602615; 20628086; 20679960; 20686565; 20691829; 20864672; 20935630; 20972250; 21139048; 21145461; 21262914; 21343306; 21355415; 21360500; 21427285; 21433257; 21530605; 21778231; 21799150; 21801748; 21890473; 21906983; 21909109; 21944868; 21963094; 21987572; 22024489; 22053931; 22143767; 22177940; 22505724; 22858685; 23000965; 23223569; 23642566; 23933271; 24025715; 24233489; 24371122
description: 3-hydroxy-3-methylglutaryl-CoA reductase
database cross reference: Ensembl:ENSG00000113161
database cross reference: HGNC:5006
database cross reference: HPRD:00836
database cross reference: MIM:142910
database cross reference: Vega:OTTHUMG00000102069

HMOX1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HMOX1D
alternative term: HO-1
alternative term: HSP32
alternative term: bK286B10
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HMOX1
full name from nomenclature authority: heme oxygenase (decycling) 1
NCBI GeneID: 3162
NCBI LocusTag: CTA-286B10.6
gene map location: 22q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001525 (EC: TAS, PMID: 12239590); GO_0001935 (EC: TAS, PMID: 12239590); GO_0002246 (EC: IMP, PMID: 9884342); GO_0002686 (EC: TAS, PMID: 14525760); GO_0004392 (EC: IDA, PMID: 17915953); GO_0004392 (EC: IMP, PMID: 19556236); GO_0004630 (EC: IEA); GO_0004871 (EC: IMP, PMID: 12761501); GO_0005615 (EC: TAS, PMID: 18307065); GO_0005634 (EC: ISS); GO_0005730 (EC: IEA); GO_0005783 (EC: IDA, PMID: 19556236); GO_0005783 (EC: ISS); GO_0005789 (EC: TAS); GO_0005829 (EC: IEA); GO_0005901 (EC: IEA); GO_0006778 (EC: TAS); GO_0006788 (EC: IDA, PMID: 17915953); GO_0006879 (EC: TAS); GO_0006979 (EC: IMP, PMID: 9884342); GO_0007264 (EC: IEA); GO_0007588 (EC: IC, PMID: 17915953); GO_0008217 (EC: IEA); GO_0008219 (EC: ISS); GO_0008630 (EC: IEA); GO_0010656 (EC: IEA); GO_0014806 (EC: TAS, PMID: 18289072); GO_0016020 (EC: TAS, PMID: 3345742); GO_0019899 (EC: ISS, PMID: 15516695); GO_0020037 (EC: IDA, PMID: 17915953); GO_0031670 (EC: IEA); GO_0032764 (EC: IEA); GO_0034101 (EC: IMP, PMID: 9884342); GO_0034383 (EC: TAS, PMID: 9884342); GO_0035094 (EC: IDA, PMID: 18205746); GO_0035556 (EC: TAS, PMID: 17652371); GO_0042167 (EC: IDA, PMID: 17915953); GO_0042167 (EC: TAS); GO_0042542 (EC: ISS); GO_0042803 (EC: IDA, PMID: 19556236); GO_0043123 (EC: IMP, PMID: 12761501); GO_0043305 (EC: IEA); GO_0043392 (EC: IEA); GO_0043433 (EC: IEA); GO_0043524 (EC: IEA); GO_0043619 (EC: ISS); GO_0043627 (EC: IEA); GO_0044281 (EC: TAS); GO_0045080 (EC: TAS, PMID: 17652371); GO_0045765 (EC: TAS, PMID: 17652371); GO_0045766 (EC: IEA); GO_0045909 (EC: IC, PMID: 17915953); GO_0046872 (EC: IEA); GO_0048661 (EC: IDA, PMID: 17600318); GO_0048662 (EC: IDA, PMID: 17600318); GO_0051090 (EC: ISS); GO_0051260 (EC: IDA, PMID: 19556236); GO_0055072 (EC: IDA, PMID: 17915953); GO_0055072 (EC: IMP, PMID: 9884342); GO_0055085 (EC: TAS); GO_0071243 (EC: IEA); GO_0071276 (EC: IEA); GO_0071456 (EC: IEP, PMID: 12511571); GO_1902042 (EC: IMP, PMID: 18202225)
has PubMed association: PMID: 2537723; 2911585; 3345742; 7778849; 8034330; 8146161; 8650873; 9884342; 9890653; 10082382; 10467099; 10591208; 10631150; 10952020; 11385506; 11718398; 11727267; 11786534; 11820797; 11829463; 11849436; 11986386; 12086318; 12091240; 12099373; 12117910; 12118938; 12130498; 12133007; 12136229; 12151344; 12153964; 12182912; 12202863; 12207883; 12222997; 12239590; 12376298; 12376363; 12376366; 12377749; 12379283; 12396617; 12397597; 12431619; 12433915; 12469218; 12477932; 12480749; 12493432; 12500973; 12511571; 12566526; 12579334; 12585963; 12626517; 12649161; 12679469; 12690112; 12709566; 12709568; 12709569; 12709590; 12709592; 12716475; 12730098; 12736395; 12761501; 12777398; 12783778; 12805077; 12810075; 12832044; 12842469; 12865654; 12872043; 12891549; 12909459; 12927812; 12927819; 12933701; 12941774; 12947311; 12969148; 13678532; 14521259; 14523007; 14525760; 14529548; 14587309; 14615405; 14635185; 14647439; 14660632; 14683741; 14691581; 14715242; 14726403; 14733911; 14981149; 14988408; 14992466; 15004156; 15024026; 15028349; 15049686; 15064108; 15084931; 15140586; 15161530; 15166181; 15184199; 15233805; 15284058; 15285018; 15297453; 15316927; 15319861; 15336443; 15337692; 15342556; 15365571; 15451051; 15461802; 15465821; 15470195; 15474356; 15516695; 15519649; 15522396; 15525643; 15544924; 15547665; 15581622; 15611319; 15618017; 15629867; 15652505; 15661856; 15688187; 15690204; 15741166; 15763346; 15797262; 15797755; 15805230; 15817713; 15833736; 15834587; 15849554; 15875813; 15878918; 15885363; 15897578; 15899048; 15964514; 16020495; 16100019; 16117883; 16123320; 16154535; 16181102; 16189191; 16210136; 16232329; 16234431; 16249618; 16271489; 16309585; 16309586; 16309588; 16313248; 16319139; 16374439; 16387424; 16399210; 16455537; 16462769; 16474202; 16485041; 16495813; 16530877; 16540907; 16545694; 16582079; 16596642; 16609364; 16620829; 16697692; 16712795; 16724942; 16771696; 16772700; 16783602; 16804400; 16840713; 16849502; 16882737; 16887359; 16923960; 169…
description: heme oxygenase (decycling) 1
database cross reference: Ensembl:ENSG00000100292
database cross reference: HGNC:5013
database cross reference: HPRD:00782
database cross reference: MIM:141250
database cross reference: Vega:OTTHUMG00000150960

HSPA1B
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HSP70-1B
alternative term: HSP70-2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HSPA1B
full name from nomenclature authority: heat shock 70kDa protein 1B
NCBI GeneID: 3304
NCBI LocusTag: DAAP-21F2.7
gene map location: 6p21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001618 (EC: IEA); GO_0003725 (EC: IDA); GO_0005515 (EC: IPI, PMID: 12853476); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA, PMID: 10205060); GO_0005737 (EC: IDA, PMID: 10859165); GO_0005737 (EC: TAS, PMID: 16130169); GO_0005739 (EC: TAS, PMID: 16130169); GO_0005783 (EC: TAS, PMID: 16130169); GO_0005829 (EC: TAS); GO_0006402 (EC: IDA, PMID: 10205060); GO_0006986 (EC: IDA, PMID: 10859165); GO_0008180 (EC: IDA, Qualifier: colocalizes_with, PMID: 18850735); GO_0008285 (EC: IMP, PMID: 9553041); GO_0010467 (EC: TAS); GO_0016070 (EC: TAS); GO_0016071 (EC: TAS); GO_0016234 (EC: IDA, PMID: 15603737); GO_0016235 (EC: IDA, PMID: 15885686); GO_0016607 (EC: IDA, PMID: 9553041); GO_0030308 (EC: IMP, PMID: 9553041); GO_0030529 (EC: IDA, PMID: 17289661); GO_0031625 (EC: IPI, PMID: 15603737); GO_0042026 (EC: IDA, PMID: 15603737); GO_0043066 (EC: IMP, PMID: 17167422); GO_0043066 (EC: TAS, PMID: 16130169); GO_0044183 (EC: IDA, PMID: 15603737); GO_0044822 (EC: IDA); GO_0045648 (EC: IMP, PMID: 17167422); GO_0047485 (EC: IPI, PMID: 9553041); GO_0048471 (EC: IDA, PMID: 10205060); GO_0051082 (EC: TAS, PMID: 16130169); GO_0070062 (EC: IDA, PMID: 19199708); GO_0072562 (EC: IDA); GO_0090084 (EC: IDA, PMID: 15603737); GO_2001240 (EC: IMP, PMID: 17167422)
has PubMed association: PMID: 1478667; 1700760; 2538825; 2858050; 2880793; 3019832; 3470951; 3786141; 3931075; 7906708; 9553041; 10205060; 10216320; 10617616; 10859165; 10964507; 11231577; 11533664; 11696222; 11730740; 11779758; 11864979; 11932435; 11971973; 12008944; 12082592; 12207910; 12391142; 12411538; 12477932; 12490434; 12544996; 12691826; 12703993; 12730033; 12832005; 12853476; 12967056; 14506234; 14574404; 14605873; 14656967; 15165109; 15223990; 15232679; 15236755; 15324660; 15489334; 15492215; 15603737; 15671022; 15714129; 15748471; 15885686; 15963462; 15963589; 15992611; 16130169; 16165702; 16169070; 16202503; 16236267; 16275660; 16333988; 16344560; 16441767; 16525348; 16713569; 16804002; 16953332; 16964243; 17081983; 17158748; 17167422; 17289661; 17301649; 17311111; 17314700; 17342744; 17364813; 17428599; 17532782; 17558451; 17582394; 17620599; 17940904; 18191480; 18299791; 18344806; 18478330; 18518860; 18529014; 18551993; 18580445; 18759004; 18813331; 18818748; 18822209; 18844219; 18850735; 18975920; 18987644; 19019335; 19046306; 19085089; 19199708; 19275587; 19287380; 19299493; 19322201; 19335985; 19351530; 19380743; 19439993; 19527514; 19596686; 19626584; 19643584; 19661373; 19731315; 19738201; 19754858; 19759913; 19840767; 19851445; 20012387; 20043082; 20140262; 20207250; 20388090; 20498198; 20568452; 20587610; 20639865; 20692469; 20704535; 20714140; 20876613; 20972266; 21139048; 21145461; 21360678; 21373891; 21471543; 21487019; 21693764; 21738007; 21738476; 21763498; 21890473; 21906983; 21963094; 21970979; 21987572; 21988832; 22037874; 22053931; 22160620; 22268729; 22323290; 22468780; 22505724; 22623428; 22797398; 22834788; 22883735; 22922572; 23000965; 23065205; 23182705; 23184937; 23246001; 23330093; 23349634; 23425104; 23455922; 23490384; 23798571; 23862649; 23874968; 23885119; 24457600
description: heat shock 70kDa protein 1B
database cross reference: Ensembl:ENSG00000204388
database cross reference: HGNC:5233
database cross reference: HPRD:06784
database cross reference: MIM:603012
database cross reference: Vega:OTTHUMG00000031202

HSPA5
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BIP
alternative term: GRP78
alternative term: HEL-S-89n
alternative term: MIF2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HSPA5
full name from nomenclature authority: heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
NCBI GeneID: 3309
gene map location: 9q33.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002576 (EC: TAS); GO_0005509 (EC: TAS, PMID: 16130169); GO_0005515 (EC: IPI, PMID: 11907036); GO_0005524 (EC: IEA); GO_0005634 (EC: IMP, PMID: 11943137); GO_0005783 (EC: IDA, PMID: 16223484); GO_0005783 (EC: IMP, PMID: 11943137); GO_0005783 (EC: TAS, PMID: 16130169); GO_0005788 (EC: TAS); GO_0005789 (EC: TAS); GO_0005793 (EC: IDA, PMID: 15308636); GO_0006200 (EC: ISS); GO_0006983 (EC: IEA); GO_0006987 (EC: TAS); GO_0007596 (EC: TAS); GO_0008180 (EC: IDA, Qualifier: colocalizes_with, PMID: 18850735); GO_0009986 (EC: IEA); GO_0016887 (EC: ISS); GO_0019904 (EC: IPI, PMID: 12411443); GO_0021589 (EC: IEA); GO_0021680 (EC: IEA); GO_0021762 (EC: IEP); GO_0030168 (EC: TAS); GO_0030176 (EC: IDA, PMID: 11181571); GO_0030335 (EC: IMP); GO_0030433 (EC: TAS, PMID: 19816510); GO_0030496 (EC: IDA, PMID: 15166316); GO_0030512 (EC: IEA); GO_0030968 (EC: TAS, PMID: 19816510); GO_0031398 (EC: IEA); GO_0031625 (EC: IPI, PMID: 8666824); GO_0034663 (EC: IDA, PMID: 18400946); GO_0035437 (EC: IMP); GO_0042149 (EC: IDA, PMID: 10085239); GO_0042470 (EC: IEA); GO_0043022 (EC: IEA); GO_0043066 (EC: IMP, PMID: 10760948); GO_0043066 (EC: TAS, PMID: 16130169); GO_0044267 (EC: TAS); GO_0051082 (EC: TAS, PMID: 16130169); GO_0051087 (EC: TAS, PMID: 19816510); GO_0051787 (EC: IDA, PMID: 18400946); GO_0060904 (EC: TAS, PMID: 19816510); GO_0070062 (EC: IDA, PMID: 19056867); GO_0071236 (EC: IEA); GO_0071353 (EC: IEA)
has PubMed association: PMID: 1480470; 1602151; 1649196; 1900540; 2294010; 2840249; 3087629; 3122216; 7724523; 7878056; 7906708; 7957306; 8020977; 8666824; 9006956; 9150946; 9150948; 9305856; 9409741; 9492298; 9885241; 10049727; 10085239; 10197448; 10397760; 10461883; 10514465; 10588643; 10617616; 10708769; 10760948; 10777498; 10887119; 10906332; 10964507; 10964928; 10970892; 11013075; 11160188; 11162507; 11162551; 11181571; 11294872; 11476899; 11719466; 11751874; 11752154; 11765911; 11790298; 11907036; 11932435; 11943137; 12076252; 12097557; 12194978; 12356756; 12359150; 12383251; 12397072; 12411443; 12471035; 12475965; 12477932; 12480769; 12493773; 12514190; 12516782; 12552023; 12621026; 12637535; 12643545; 12665508; 12713871; 12832005; 12840015; 15009096; 15077298; 15146195; 15150263; 15166316; 15280358; 15308636; 15324660; 15456888; 15489334; 15514946; 15525676; 15618547; 15635413; 15657421; 15664986; 15778089; 15817150; 15899857; 15908432; 15949590; 15952740; 16027165; 16051665; 16130169; 16168956; 16169070; 16182273; 16196087; 16212417; 16223484; 16236267; 16257961; 16282978; 16329989; 16344560; 16400691; 16428306; 16472112; 16488447; 16497268; 16522924; 16543232; 16731524; 16912156; 16912197; 17002502; 17062670; 17081065; 17139257; 17184779; 17215244; 17220478; 17337485; 17380188; 17431395; 17601350; 17620599; 17640713; 17643375; 17670764; 17683050; 17721549; 17725712; 17728248; 17765891; 17805346; 17848573; 17906960; 17931354; 17932454; 17936241; 17942541; 17979178; 17991893; 18022401; 18064632; 18083346; 18192872; 18264092; 18268478; 18278507; 18331622; 18343577; 18400946; 18403493; 18411300; 18457437; 18482745; 18502753; 18556570; 18654987; 18708056; 18708359; 18720263; 18757373; 18776923; 18781276; 18781797; 18790759; 18840615; 18842681; 18850735; 18977241; 19014922; 19017364; 19056867; 19097122; 19103594; 19107326; 19128512; 19135240; 19151922; 19164805; 19165527; 19167051; 19188365; 19193609; 19212831; 19228285; 19236758; 19275587; 19287380; 19296942; 19309398; 19343720; 19380…
description: heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
database cross reference: Ensembl:ENSG00000044574
database cross reference: HGNC:5238
database cross reference: HPRD:00682
database cross reference: MIM:138120
database cross reference: Vega:OTTHUMG00000020672

HSPD1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CPN60
alternative term: GROEL
alternative term: HLD4
alternative term: HSP-60
alternative term: HSP60
alternative term: HSP65
alternative term: HuCHA60
alternative term: SPG13
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HSPD1
full name from nomenclature authority: heat shock 60kDa protein 1 (chaperonin)
NCBI GeneID: 3329
gene map location: 2q33.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001530 (EC: IDA, PMID: 17164250); GO_0002039 (EC: IPI, PMID: 18086682); GO_0002368 (EC: IDA, PMID: 16148103); GO_0002755 (EC: IDA, PMID: 16148103); GO_0002842 (EC: IDA, PMID: 10663613); GO_0003688 (EC: ISS); GO_0003697 (EC: ISS); GO_0003725 (EC: IDA); GO_0005515 (EC: IPI, PMID: 17823127); GO_0005524 (EC: IEA); GO_0005615 (EC: IDA, PMID: 18229457); GO_0005737 (EC: IDA); GO_0005739 (EC: IDA); GO_0005743 (EC: ISS); GO_0005759 (EC: TAS, PMID: 17823127); GO_0005769 (EC: IDA, PMID: 11807771); GO_0005829 (EC: IDA, PMID: 17823127); GO_0005886 (EC: IEA); GO_0005905 (EC: IDA, PMID: 11807771); GO_0006200 (EC: ISS); GO_0006458 (EC: ISS); GO_0006919 (EC: IDA, PMID: 17823127); GO_0006986 (EC: IDA, PMID: 11050098); GO_0009986 (EC: IDA, PMID: 10663613); GO_0016032 (EC: IEA); GO_0016887 (EC: ISS); GO_0019907 (EC: IDA, Qualifier: colocalizes_with, PMID: 11445587); GO_0030135 (EC: IDA, PMID: 11807771); GO_0030141 (EC: ISS); GO_0032727 (EC: IDA, PMID: 17164250); GO_0032729 (EC: IDA, PMID: 17164250); GO_0032729 (EC: ISS); GO_0032733 (EC: IDA, PMID: 16148103); GO_0032735 (EC: IDA, PMID: 17164250); GO_0032755 (EC: IDA, PMID: 16148103); GO_0042026 (EC: IDA, PMID: 11050098); GO_0042100 (EC: IDA, PMID: 16148103); GO_0042110 (EC: IDA, PMID: 15371451); GO_0042113 (EC: IDA, PMID: 16148103); GO_0043032 (EC: IDA, PMID: 17164250); GO_0043065 (EC: IMP, PMID: 17823127); GO_0043066 (EC: IMP, PMID: 17823127); GO_0043234 (EC: IDA); GO_0044822 (EC: IDA); GO_0046696 (EC: IDA, PMID: 17164250); GO_0048291 (EC: IDA, PMID: 16148103); GO_0050821 (EC: IMP, PMID: 18086682); GO_0050821 (EC: ISS); GO_0050870 (EC: IDA, PMID: 16148103); GO_0050870 (EC: ISS); GO_0051082 (EC: IC, PMID: 11050098); GO_0051082 (EC: ISS); GO_0051087 (EC: IPI, PMID: 10205158); GO_0051131 (EC: ISS); GO_0051604 (EC: ISS); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1286669; 1347942; 1516759; 1602151; 1972619; 1980192; 2079031; 2568584; 2907406; 7518175; 7895732; 7907543; 7911805; 8559246; 8671282; 8676499; 8678928; 8689794; 8845058; 8882520; 8976559; 8979276; 9051195; 9150946; 9150948; 9243807; 9724719; 9890926; 10205158; 10205159; 10231001; 10231004; 10326659; 10382997; 10449265; 10467106; 10499815; 10508170; 10632533; 10663613; 10677329; 10731000; 10811634; 10960671; 11050098; 11144526; 11145923; 11230124; 11337467; 11445587; 11488911; 11591125; 11689615; 11777905; 11790298; 11807771; 11860186; 11862386; 11888933; 11898127; 11932435; 12070120; 12105158; 12195124; 12215374; 12218165; 12234937; 12387818; 12406306; 12461076; 12477932; 12483302; 12493773; 12515899; 12552239; 12594256; 12611882; 12665801; 12684064; 12686536; 12768547; 12813381; 12869561; 12890148; 12942564; 12965262; 14500649; 14634555; 14717702; 14968112; 15047060; 15242332; 15249499; 15251360; 15324660; 15371451; 15489334; 15529360; 15546885; 15590416; 15592455; 15618521; 15635413; 15661886; 15763499; 15784682; 15875659; 15879154; 15952740; 15957980; 16009940; 16075307; 16116071; 16130169; 16148103; 16159877; 16196087; 16212417; 16215457; 16236267; 16253146; 16254226; 16320351; 16335966; 16482509; 16705742; 16723087; 16767222; 16843693; 16887805; 16964243; 16978514; 17072495; 17075864; 17110338; 17148442; 17164250; 17174952; 17202307; 17206383; 17314511; 17317785; 17420921; 17420924; 17540176; 17553457; 17584768; 17588138; 17643375; 17670764; 17675567; 17681147; 17823127; 17915559; 17925998; 18029348; 18086682; 18229457; 18240224; 18256040; 18319262; 18320357; 18322079; 18372523; 18399535; 18400758; 18457437; 18458233; 18571143; 18685789; 18692161; 18781797; 18790094; 18815895; 18987317; 19004824; 19008717; 19022255; 19056867; 19106391; 19109096; 19110265; 19132982; 19156129; 19205928; 19207939; 19210880; 19261350; 19264393; 19306954; 19336475; 19338310; 19343720; 19346294; 19369584; 19380743; 19386281; 19423133; 19471022; 19475432; 19565483; 19568603; 19…
description: heat shock 60kDa protein 1 (chaperonin)
database cross reference: Ensembl:ENSG00000144381
database cross reference: HGNC:5261
database cross reference: HPRD:00318
database cross reference: MIM:118190
database cross reference: Vega:OTTHUMG00000154463

ICAM1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BB2
alternative term: CD54
alternative term: P3.58
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ICAM1
full name from nomenclature authority: intercellular adhesion molecule 1
NCBI GeneID: 3383
gene map location: 19p13.3-p13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001541 (EC: IEA); GO_0001618 (EC: IEA); GO_0001772 (EC: IEA); GO_0001910 (EC: TAS, PMID: 16038038); GO_0001975 (EC: IEA); GO_0002291 (EC: IMP, PMID: 2477710); GO_0002457 (EC: IEA); GO_0002693 (EC: IMP, PMID: 12902516); GO_0004872 (EC: TAS, PMID: 2538243); GO_0004888 (EC: TAS, PMID: 2538243); GO_0005178 (EC: IPI, PMID: 1448173); GO_0005515 (EC: IPI, PMID: 12716892); GO_0005615 (EC: IDA, PMID: 9290466); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 2538243); GO_0007155 (EC: IDA, PMID: 16809613); GO_0007157 (EC: TAS, PMID: 2477710); GO_0007159 (EC: IMP, PMID: 2477710); GO_0007569 (EC: IEA); GO_0008360 (EC: IEA); GO_0009897 (EC: IEA); GO_0010212 (EC: IEA); GO_0010477 (EC: IEA); GO_0014070 (EC: IEA); GO_0019221 (EC: TAS); GO_0022614 (EC: IEP, PMID: 12082081); GO_0030155 (EC: IEA); GO_0030198 (EC: TAS); GO_0030838 (EC: IEA); GO_0031669 (EC: IEA); GO_0032321 (EC: IEA); GO_0033627 (EC: IEA); GO_0034698 (EC: IEA); GO_0042493 (EC: IEA); GO_0043200 (EC: IEA); GO_0045429 (EC: IEA); GO_0045471 (EC: IEA); GO_0045907 (EC: IEA); GO_0046688 (EC: IEA); GO_0046813 (EC: IDA, PMID: 2538243); GO_0050731 (EC: IEA); GO_0050776 (EC: TAS); GO_0050900 (EC: IEP, PMID: 12082081); GO_0051092 (EC: IEA); GO_0051856 (EC: IDA, PMID: 2538243); GO_0051926 (EC: IEA); GO_0060333 (EC: TAS); GO_0061028 (EC: IGI); GO_0070062 (EC: IDA, PMID: 19056867); GO_0071222 (EC: IEA); GO_0071312 (EC: IEA); GO_0071333 (EC: IEA); GO_0071347 (EC: IEA); GO_0071356 (EC: IEA); GO_0071456 (EC: IEA)
has PubMed association: PMID: 1361527; 1374132; 1448173; 1625472; 1677359; 1680025; 1680698; 1680919; 1683616; 1683685; 1705751; 1712819; 1722744; 1976256; 1983003; 2453850; 2477710; 2538243; 2544880; 2566624; 3257922; 3340213; 3349522; 3871395; 7525451; 7642561; 7794538; 7822297; 7904170; 7913356; 7917519; 8086129; 8095960; 8432525; 8450224; 8557254; 8558011; 8568270; 8821031; 9259284; 9269771; 9290466; 9488691; 9539702; 9539703; 9705328; 9792375; 9865497; 10198043; 10352278; 10391210; 10477700; 10493852; 10562537; 10602408; 10699175; 10985244; 11072593; 11073102; 11250042; 11279101; 11354638; 11361181; 11409120; 11441079; 11469468; 11508575; 11517385; 11716965; 11726228; 11751911; 11776680; 11786177; 11817671; 11831440; 11831864; 11837795; 11838958; 11847011; 11857637; 11877286; 11881155; 11882338; 11893710; 11896203; 11911111; 11914659; 11922836; 11922919; 11929876; 11935152; 11936473; 11953106; 11956618; 11963839; 11983194; 11983205; 12011765; 12020443; 12027924; 12039084; 12082081; 12082592; 12086338; 12095649; 12097408; 12097820; 12117984; 12127369; 12147222; 12172318; 12172576; 12175089; 12181421; 12192299; 12207164; 12208882; 12220988; 12368450; 12370391; 12391099; 12393699; 12402194; 12477764; 12477932; 12480084; 12496412; 12498973; 12506144; 12509902; 12524171; 12526797; 12529420; 12530121; 12533701; 12590979; 12595908; 12600815; 12624779; 12637697; 12645577; 12660163; 12660796; 12673844; 12714373; 12714566; 12715098; 12716892; 12745437; 12768436; 12775419; 12783117; 12783123; 12788528; 12798307; 12808331; 12829919; 12853962; 12871600; 12902516; 12915579; 12918698; 12939654; 12940514; 12946329; 12954625; 12958678; 14504278; 14533030; 14534081; 14550782; 14551606; 14557478; 14572449; 14572618; 14581566; 14605444; 14609725; 14634129; 14643123; 14691297; 14695458; 14714557; 14722298; 14734737; 14737745; 14741380; 14742996; 14763917; 14763979; 14975197; 14984317; 14993495; 15009098; 15013836; 15048650; 15057477; 15059493; 15080580; 15081401; 15094060; 15123348; 15140794; 15169768; 15…
description: intercellular adhesion molecule 1
database cross reference: Ensembl:ENSG00000090339
database cross reference: HGNC:5344
database cross reference: HPRD:00996
database cross reference: MIM:147840
database cross reference: Vega:OTTHUMG00000180403

IDE
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: INSULYSIN
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IDE
full name from nomenclature authority: insulin-degrading enzyme
NCBI GeneID: 3416
NCBI LocusTag: RP11-366I13.1
gene map location: 10q23-q25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001540 (EC: IEA); GO_0001948 (EC: IPI, PMID: 17055432); GO_0004222 (EC: IDA, PMID: 17051221); GO_0005102 (EC: IPI); GO_0005515 (EC: IPI, PMID: 17715127); GO_0005524 (EC: IDA, PMID: 17613531); GO_0005615 (EC: IDA, PMID: 9830016); GO_0005634 (EC: IDA, PMID: 15285718); GO_0005634 (EC: IDA, Qualifier: NOT, PMID: 18226493); GO_0005737 (EC: IDA, PMID: 18226493); GO_0005739 (EC: IDA, PMID: 15285718); GO_0005777 (EC: IDA, PMID: 9231799); GO_0005782 (EC: IEA); GO_0005829 (EC: IDA, PMID: 15285718); GO_0005886 (EC: IEA); GO_0006508 (EC: IDA); GO_0008270 (EC: IDA, PMID: 17613531); GO_0008286 (EC: NAS, PMID: 3059494); GO_0008340 (EC: IDA, PMID: 18448515); GO_0009986 (EC: IDA, PMID: 17055432); GO_0010815 (EC: IDA, PMID: 17613531); GO_0010992 (EC: IDA); GO_0016032 (EC: IEA); GO_0016887 (EC: IEA); GO_0031597 (EC: IEA); GO_0031626 (EC: IEA); GO_0032461 (EC: IDA, PMID: 9830016); GO_0042277 (EC: IPI); GO_0042447 (EC: IEA); GO_0042803 (EC: IPI, PMID: 17613531); GO_0043130 (EC: IPI); GO_0043559 (EC: IDA, PMID: 17051221); GO_0043559 (EC: IPI); GO_0045861 (EC: IEA); GO_0050435 (EC: IDA, PMID: 17613531); GO_0051260 (EC: IDA, PMID: 17051221); GO_0051289 (EC: IEA); GO_0051291 (EC: IEA); GO_0051603 (EC: IDA, PMID: 9830016); GO_1901142 (EC: IDA, PMID: 18448515); GO_1901143 (EC: IDA, PMID: 9231799)
has PubMed association: PMID: 758022; 1607078; 1733942; 1743072; 2293021; 3059494; 6401723; 7731996; 8051160; 8077210; 8425612; 9070242; 9231799; 9830016; 10684867; 11145591; 11809755; 12161276; 12477932; 12507914; 12634421; 12716770; 12746301; 12765971; 12850277; 14517947; 14702039; 14755451; 14764804; 15024728; 15088150; 15181249; 15277398; 15277615; 15285718; 15489232; 15590928; 15718037; 15850385; 15858813; 15858821; 15911128; 16344560; 16380485; 16385451; 16511862; 16574064; 16675064; 16876916; 16914266; 17051221; 17055432; 17143514; 17192720; 17192785; 17244626; 17293876; 17463249; 17496198; 17579348; 17601350; 17613531; 17715127; 17804762; 17827400; 17913278; 17953957; 17964527; 17971426; 18212765; 18226493; 18411275; 18426861; 18448515; 18591388; 18618095; 18621727; 18633108; 18719881; 18783335; 18813847; 18977241; 18984664; 18986166; 18996360; 19019493; 19053027; 19082521; 19139842; 19228808; 19239107; 19321446; 19383491; 19396426; 19453261; 19592050; 19592620; 19602701; 19606063; 19622614; 19741166; 19785409; 19794065; 19808678; 19808892; 19809796; 19862325; 19864391; 19864659; 19889475; 19896952; 19913121; 19933996; 20033747; 20082125; 20098734; 20161779; 20178365; 20203524; 20360068; 20362553; 20364150; 20380468; 20384434; 20460429; 20490451; 20581827; 20628086; 20663017; 20703447; 20724036; 20816152; 20877624; 20880607; 20927120; 20971110; 21098034; 21139048; 21185309; 21232820; 21343292; 21731745; 21800051; 21873424; 21890473; 21903422; 21906983; 21963094; 21992747; 22036964; 22053931; 22107728; 22267728; 22502914; 22837378; 22863883; 23000965; 23036584; 23416320; 23525105; 23597493; 23922390; 24250222
description: insulin-degrading enzyme
database cross reference: Ensembl:ENSG00000119912
database cross reference: HGNC:5381
database cross reference: HPRD:00894
database cross reference: MIM:146680
database cross reference: Vega:OTTHUMG00000018759

IFNG
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IFG
alternative term: IFI
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IFNG
full name from nomenclature authority: interferon, gamma
NCBI GeneID: 3458
gene map location: 12q14
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000060 (EC: IDA, PMID: 15604419); GO_0000122 (EC: ISS); GO_0001781 (EC: IEA); GO_0002026 (EC: IEA); GO_0002053 (EC: ISS); GO_0002250 (EC: IBA); GO_0002302 (EC: IEA); GO_0003340 (EC: ISS); GO_0005125 (EC: IBA); GO_0005133 (EC: IEA); GO_0005576 (EC: IDA); GO_0005576 (EC: TAS); GO_0005615 (EC: IBA); GO_0006915 (EC: IGI, PMID: 7828849); GO_0006928 (EC: TAS, PMID: 10477596); GO_0006959 (EC: IBA); GO_0007050 (EC: IDA, PMID: 16942485); GO_0007166 (EC: TAS, PMID: 10477596); GO_0009615 (EC: IDA, PMID: 16280321); GO_0009897 (EC: IEA); GO_0019221 (EC: TAS); GO_0019882 (EC: IEA); GO_0030593 (EC: IEA); GO_0030968 (EC: IEA); GO_0031642 (EC: IEA); GO_0032224 (EC: IEA); GO_0032700 (EC: IDA, PMID: 18501882); GO_0032735 (EC: IDA, PMID: 7605994); GO_0032747 (EC: IDA); GO_0032760 (EC: IEA); GO_0033141 (EC: IDA, PMID: 16280321); GO_0033141 (EC: NAS); GO_0034393 (EC: IDA, PMID: 16942485); GO_0042102 (EC: IEA); GO_0042493 (EC: IEA); GO_0042511 (EC: IDA, PMID: 15604419); GO_0042742 (EC: IEA); GO_0042832 (EC: IEA); GO_0044130 (EC: IEA); GO_0045080 (EC: IEA); GO_0045084 (EC: IEA); GO_0045348 (EC: IEA); GO_0045410 (EC: IEA); GO_0045429 (EC: IDA, PMID: 8383325); GO_0045666 (EC: IEA); GO_0045672 (EC: IDA, PMID: 16220542); GO_0045785 (EC: IEA); GO_0045944 (EC: IEA); GO_0048304 (EC: IEA); GO_0048662 (EC: IDA, PMID: 16942485); GO_0050718 (EC: IEA); GO_0050796 (EC: IDA, PMID: 8383325); GO_0051044 (EC: IDA, PMID: 18373975); GO_0051607 (EC: IEA); GO_0051712 (EC: IDA, PMID: 7544003); GO_0060333 (EC: TAS); GO_0060334 (EC: TAS); GO_0060550 (EC: IDA, PMID: 9282826); GO_0060552 (EC: IDA, PMID: 9282826); GO_0060557 (EC: IDA, PMID: 9282826); GO_0060559 (EC: IDA, PMID: 9282826); GO_0071222 (EC: IEA); GO_0071351 (EC: IEA); GO_0072308 (EC: ISS); GO_0097191 (EC: IDA, PMID: 16942485); GO_2000309 (EC: IDA, PMID: 16220542)
has PubMed association: PMID: 1400376; 1525157; 1662603; 1708818; 1902591; 1905933; 1905983; 2452186; 2504704; 2514776; 2860101; 3109913; 3139842; 6173769; 6176945; 6180322; 6305337; 6329718; 6427223; 7511078; 7523014; 7526537; 7544003; 7583919; 7587386; 7590734; 7605994; 7617032; 7673114; 7815507; 7818827; 7828849; 7904170; 7941321; 8065455; 8102828; 8188658; 8247028; 8345204; 8383325; 8537091; 8557999; 8598486; 8619916; 8631301; 8648753; 8661419; 8679287; 8706326; 8760410; 8764000; 8765022; 8769094; 8809126; 8974399; 9108403; 9225992; 9282826; 9534962; 9651359; 9658081; 9712080; 9743208; 9916748; 10358150; 10388525; 10438928; 10446807; 10477596; 10775602; 10860730; 10933622; 10986460; 11240951; 11250200; 11266927; 11266928; 11292301; 11298489; 11298547; 11315919; 11316066; 11354638; 11391238; 11404167; 11528517; 11544427; 11544434; 11700035; 11751951; 11755617; 11772518; 11774563; 11781187; 11781192; 11786536; 11796707; 11821159; 11830476; 11831440; 11841489; 11854199; 11854210; 11857052; 11857344; 11861290; 11865054; 11876761; 11900986; 11906646; 11920321; 11936954; 11943142; 11947926; 11953317; 11964313; 11966872; 11970958; 11980899; 11981433; 11984595; 11986281; 11986939; 11991675; 12006410; 12011077; 12020266; 12042661; 12047360; 12050152; 12060750; 12070781; 12084660; 12089333; 12089714; 12097398; 12102661; 12105273; 12162871; 12162874; 12165521; 12170266; 12191570; 12192641; 12203138; 12209087; 12219025; 12223098; 12223516; 12232842; 12239181; 12296868; 12358843; 12366695; 12368207; 12370350; 12370385; 12377943; 12389079; 12393446; 12394188; 12401479; 12420205; 12438348; 12438388; 12441140; 12444137; 12451269; 12471139; 12473063; 12477932; 12479817; 12486605; 12507818; 12526950; 12531694; 12531774; 12533683; 12542496; 12548511; 12552499; 12555203; 12558814; 12579348; 12581491; 12588705; 12590978; 12594832; 12595908; 12609526; 12615834; 12633940; 12645529; 12653164; 12700631; 12727482; 12727483; 12738388; 12750172; 12751024; 12754213; 12761564; 12788307; 12788577; 12794718; 12804771…
description: interferon, gamma
database cross reference: Ensembl:ENSG00000111537
database cross reference: HGNC:5438
database cross reference: HPRD:00957
database cross reference: MIM:147570
database cross reference: Vega:OTTHUMG00000169113

IGF1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IGF-I
alternative term: IGF1A
alternative term: IGFI
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IGF1
full name from nomenclature authority: insulin-like growth factor 1 (somatomedin C)
NCBI GeneID: 3479
gene map location: 12q23.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001501 (EC: TAS, PMID: 10448861); GO_0001974 (EC: IEA); GO_0002576 (EC: TAS); GO_0005158 (EC: IPI, PMID: 8452530); GO_0005159 (EC: IPI, PMID: 8452530); GO_0005178 (EC: IDA, PMID: 19578119); GO_0005179 (EC: IDA, PMID: 7188854); GO_0005515 (EC: IPI, PMID: 10766744); GO_0005576 (EC: NAS, PMID: 14718574); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 17119061); GO_0005886 (EC: TAS); GO_0006260 (EC: TAS, PMID: 10766744); GO_0006928 (EC: TAS, PMID: 10766744); GO_0007165 (EC: TAS, PMID: 10448861); GO_0007265 (EC: TAS, PMID: 10848592); GO_0007517 (EC: TAS, PMID: 10448861); GO_0007596 (EC: TAS); GO_0008083 (EC: IEA); GO_0008284 (EC: IDA, PMID: 12746903); GO_0008285 (EC: IEA); GO_0009441 (EC: TAS, PMID: 10448861); GO_0010001 (EC: IEA); GO_0010613 (EC: IDA, PMID: 19654000); GO_0014068 (EC: IDA, PMID: 7688386); GO_0014834 (EC: IDA, PMID: 17531227); GO_0014896 (EC: IMP, PMID: 10191278); GO_0014904 (EC: IDA, PMID: 17531227); GO_0014911 (EC: IDA, PMID: 10766744); GO_0016942 (EC: IC, PMID: 10766744); GO_0021940 (EC: IEA); GO_0030104 (EC: IEA); GO_0030166 (EC: IDA, PMID: 12746903); GO_0030168 (EC: TAS); GO_0030879 (EC: IEA); GO_0031017 (EC: IEA); GO_0031093 (EC: TAS); GO_0032878 (EC: IEA); GO_0033160 (EC: IDA, PMID: 19654000); GO_0034392 (EC: IDA, PMID: 16942485); GO_0035264 (EC: IEA); GO_0035630 (EC: IDA, PMID: 16433617); GO_0040014 (EC: IEP, PMID: 8421089); GO_0042104 (EC: IDA, PMID: 15694994); GO_0042523 (EC: IDA, PMID: 9722506); GO_0043388 (EC: IDA, PMID: 19654000); GO_0043410 (EC: IDA, PMID: 19654000); GO_0043568 (EC: IDA, PMID: 10766744); GO_0044267 (EC: TAS); GO_0045445 (EC: IDA, PMID: 17531227); GO_0045669 (EC: IDA, PMID: 16433617); GO_0045725 (EC: IDA); GO_0045740 (EC: IDA, PMID: 7688386); GO_0045740 (EC: ISS); GO_0045821 (EC: IDA, PMID: 7688386); GO_0045840 (EC: IDA, PMID: 10644978); GO_0045893 (EC: IDA, PMID: 19654000); GO_0045944 (EC: IDA, PMID: 16433617); GO_0046326 (EC: IDA); GO_0046579 (EC: IDA, PMID: 9722506); GO_0048009 (EC: IEA); GO_0048015 (EC: IDA, PMID: 7…
has PubMed association: PMID: 632300; 1147105; 1319992; 1370435; 1372070; 1383255; 1733942; 1791841; 1852007; 2018498; 2036417; 2082190; 2752154; 2935423; 2937782; 2982726; 3002851; 3242681; 3455760; 3683205; 4550398; 6189745; 6358902; 6382022; 7188854; 7511544; 7683646; 7688386; 7692086; 7720641; 7782332; 7916968; 8421089; 8452530; 8495408; 8857020; 8939990; 9138096; 9446566; 9453236; 9497324; 9681507; 9722506; 9722589; 9831081; 9853872; 9857239; 10084601; 10191278; 10205209; 10226805; 10350456; 10381171; 10391209; 10407151; 10448861; 10459853; 10512690; 10644978; 10749889; 10766744; 10823924; 10848592; 11063745; 11161840; 11175789; 11246885; 11319179; 11344214; 11600567; 11735247; 11749962; 11762714; 11768601; 11787050; 11822578; 11825899; 11834727; 11857446; 11858767; 11867942; 11877395; 11877670; 11896491; 11897674; 11903419; 11904589; 11907830; 11909998; 11914023; 11914026; 11924928; 11937187; 11943599; 11953210; 11964397; 11972897; 11988840; 11994280; 11994678; 12005306; 12006706; 12011046; 12011225; 12032677; 12050240; 12062094; 12070137; 12086966; 12095637; 12102164; 12111701; 12115549; 12122101; 12127559; 12135130; 12135360; 12164325; 12175483; 12186542; 12201212; 12213898; 12217887; 12218293; 12236578; 12237896; 12240900; 12356750; 12364325; 12381752; 12388463; 12389335; 12394769; 12397390; 12419777; 12424437; 12477932; 12508915; 12508916; 12508917; 12508918; 12508929; 12508940; 12509920; 12511011; 12519841; 12545204; 12555073; 12562960; 12571183; 12590635; 12590636; 12592062; 12610514; 12612059; 12631341; 12642873; 12679458; 12714114; 12716804; 12716855; 12716875; 12727948; 12729801; 12730416; 12732844; 12734180; 12735930; 12746292; 12746903; 12759337; 12787886; 12791939; 12800944; 12810534; 12842994; 12843178; 12843179; 12843187; 12858577; 12861174; 12865482; 12867429; 12870155; 12891709; 12909598; 12915683; 12919702; 12930919; 12937269; 12937290; 12943991; 12948293; 12949013; 12960100; 12970325; 13130502; 14504195; 14521955; 14557458; 14602779; 14604834; 14605256; 14631161; 14…
description: insulin-like growth factor 1 (somatomedin C)
database cross reference: Ensembl:ENSG00000017427
database cross reference: HGNC:5464
database cross reference: HPRD:00936
database cross reference: MIM:147440
database cross reference: Vega:OTTHUMG00000149910

IGF1R
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD221
alternative term: IGFIR
alternative term: IGFR
alternative term: JTK13
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IGF1R
full name from nomenclature authority: insulin-like growth factor 1 receptor
NCBI GeneID: 3480
gene map location: 15q26.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001965 (EC: IEA); GO_0004713 (EC: IDA, PMID: 11162456); GO_0004713 (EC: TAS); GO_0005010 (EC: IDA, PMID: 7679099); GO_0005158 (EC: IDA, PMID: 8452530); GO_0005515 (EC: IPI, PMID: 10026153); GO_0005520 (EC: IDA, PMID: 1846292); GO_0005524 (EC: IEA); GO_0005886 (EC: TAS); GO_0005887 (EC: IC, PMID: 7679099); GO_0005901 (EC: IEA); GO_0006955 (EC: IMP, PMID: 16886151); GO_0007165 (EC: TAS, PMID: 3003744); GO_0007409 (EC: IEA); GO_0007420 (EC: IEA); GO_0008284 (EC: TAS, PMID: 10749889); GO_0008286 (EC: TAS, PMID: 10829031); GO_0010656 (EC: IEA); GO_0014065 (EC: IC, PMID: 7541045); GO_0016020 (EC: IDA, PMID: 8452530); GO_0018108 (EC: IDA, PMID: 11162456); GO_0018108 (EC: TAS); GO_0030010 (EC: IEA); GO_0030238 (EC: IEA); GO_0030335 (EC: IMP, PMID: 12138094); GO_0030879 (EC: IEA); GO_0031017 (EC: IEA); GO_0031994 (EC: IPI, PMID: 8452530); GO_0032467 (EC: IEA); GO_0033197 (EC: IEA); GO_0042802 (EC: IPI, PMID: 11448933); GO_0043005 (EC: IEA); GO_0043066 (EC: IDA, PMID: 12556535); GO_0043231 (EC: IDA, PMID: 8452530); GO_0043235 (EC: IDA); GO_0043410 (EC: IEA); GO_0043548 (EC: IPI, PMID: 7541045); GO_0043559 (EC: IPI, PMID: 8452530); GO_0043560 (EC: IPI, PMID: 7541045); GO_0045740 (EC: IMP, PMID: 12138094); GO_0046328 (EC: IDA, PMID: 12556535); GO_0046777 (EC: IDA, PMID: 11162456); GO_0048009 (EC: IDA, PMID: 7679099); GO_0048015 (EC: IDA, PMID: 7692086); GO_0051262 (EC: IDA, PMID: 1846292); GO_0051291 (EC: IEA); GO_0051389 (EC: IDA, PMID: 12556535); GO_0051897 (EC: IEA); GO_0051898 (EC: IEA); GO_0060740 (EC: IEA); GO_0090031 (EC: IEA)
has PubMed association: PMID: 1316909; 1711844; 1846292; 1850606; 1851182; 1852007; 2877871; 2948220; 3003744; 3107886; 7541045; 7559507; 7642582; 7679099; 7692086; 7895674; 8111378; 8247543; 8452530; 8530377; 8550552; 8621530; 8626379; 8648195; 8662806; 8697095; 8710868; 8764099; 8776723; 8875975; 8889548; 8940173; 8999839; 9111084; 9355755; 9389554; 9415396; 9480911; 9491374; 9492017; 9506989; 9524259; 9553137; 9581554; 9642287; 9727029; 9745438; 9852124; 9857239; 9972281; 10026153; 10082579; 10358067; 10644671; 10655455; 10747872; 10749889; 10829031; 11071852; 11094073; 11120746; 11162456; 11250706; 11316748; 11423532; 11445579; 11448933; 11463827; 11591350; 11694888; 11724822; 11754068; 11782378; 11867942; 11884618; 11956190; 12005306; 12019176; 12031683; 12105987; 12127559; 12138094; 12138114; 12147227; 12167719; 12198159; 12220227; 12379772; 12444079; 12477932; 12482592; 12483226; 12493743; 12556535; 12593846; 12603530; 12613967; 12634644; 12644306; 12697834; 12730241; 12771153; 12784091; 12820418; 12821780; 12843179; 12876069; 12884909; 12937141; 14522909; 14551153; 14559999; 14575710; 14597618; 14615489; 14627343; 14633695; 14651979; 14654552; 14657428; 14684825; 14691011; 14697248; 14710354; 14710355; 14710359; 14710360; 14710366; 14710368; 14722023; 14726697; 14729630; 14737113; 14744783; 14764897; 14769130; 14973173; 15043778; 15059221; 15103018; 15127203; 15146197; 15181035; 15205474; 15253384; 15254679; 15256055; 15324660; 15334055; 15345673; 15358139; 15472208; 15489334; 15522217; 15564321; 15595626; 15623623; 15629149; 15638375; 15671548; 15689620; 15767667; 15797461; 15805544; 15820831; 15867218; 15878855; 15914670; 15921396; 15932773; 15954927; 16000560; 16035620; 16037379; 16053920; 16087727; 16113100; 16127155; 16172123; 16181796; 16328478; 16344560; 16362313; 16382134; 16407661; 16584539; 16595699; 16619240; 16647191; 16648580; 16750336; 16793764; 16804965; 16805964; 16827799; 16831875; 16886151; 16891453; 16962112; 16981720; 16981855; 16983186; 17014845; 17016438; 1704…
description: insulin-like growth factor 1 receptor
database cross reference: Ensembl:ENSG00000140443
database cross reference: HGNC:5465
database cross reference: HPRD:00932
database cross reference: MIM:147370
database cross reference: Vega:OTTHUMG00000149851

IKBKB
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IKK-beta
alternative term: IKK2
alternative term: IKKB
alternative term: IMD15
alternative term: NFKBIKB
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IKBKB
full name from nomenclature authority: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
NCBI GeneID: 3551
gene map location: 8p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001782 (EC: IEA); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004672 (EC: IDA); GO_0004674 (EC: TAS); GO_0005515 (EC: IPI, PMID: 10521409); GO_0005524 (EC: IEA); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0006468 (EC: IDA); GO_0006468 (EC: NAS, PMID: 9346484); GO_0006954 (EC: TAS, PMID: 18626576); GO_0007249 (EC: TAS, PMID: 18626576); GO_0007252 (EC: TAS, PMID: 18626576); GO_0008384 (EC: TAS, PMID: 18626576); GO_0008385 (EC: TAS, PMID: 18626576); GO_0009615 (EC: TAS, PMID: 18626576); GO_0009898 (EC: ISS); GO_0010765 (EC: IEA); GO_0019901 (EC: IPI, PMID: 12492477); GO_0032481 (EC: TAS); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035631 (EC: ISS); GO_0035666 (EC: TAS); GO_0035872 (EC: TAS); GO_0038095 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042501 (EC: IDA); GO_0042803 (EC: IDA); GO_0043066 (EC: TAS); GO_0043123 (EC: TAS); GO_0045087 (EC: TAS, PMID: 18626576); GO_0045121 (EC: IEA); GO_0045893 (EC: NAS, PMID: 9346484); GO_0045944 (EC: IDA); GO_0046982 (EC: IDA); GO_0048011 (EC: TAS); GO_0050852 (EC: TAS); GO_0051092 (EC: IDA, PMID: 15790681); GO_0051092 (EC: TAS, PMID: 18626576); GO_0070423 (EC: TAS); GO_0071356 (EC: IDA); GO_2001259 (EC: IEA)
has PubMed association: PMID: 8601309; 8657102; 9214631; 9252186; 9346241; 9346484; 9346485; 9520446; 9632806; 9689078; 9721103; 9744859; 9751059; 9751060; 9763654; 9813230; 9819420; 9878263; 9891086; 9914500; 10022904; 10195894; 10356400; 10469655; 10485711; 10497169; 10521409; 10713178; 10722755; 10723127; 10733566; 10755617; 10779355; 10783893; 10807933; 10848580; 10962033; 10968790; 10980203; 11002417; 11057907; 11080499; 11096118; 11113112; 11120819; 11158290; 11278268; 11359906; 11429546; 11460167; 11527961; 11585904; 11594795; 11606564; 11777949; 11815618; 11821416; 11830587; 11839743; 11864612; 11945026; 11954826; 11959143; 11971985; 11976329; 12054687; 12070292; 12133833; 12210728; 12244103; 12351658; 12393548; 12411322; 12459277; 12477932; 12482991; 12486103; 12486112; 12492477; 12547194; 12589056; 12612076; 12637324; 12645577; 12657630; 12707358; 12709429; 12842894; 12890679; 12943667; 14514672; 14560022; 14585846; 14585847; 14585990; 14597638; 14625285; 14654787; 14702039; 14715628; 14743216; 14990741; 15084260; 15125834; 15128824; 15140882; 15184390; 15217951; 15218148; 15226300; 15254232; 15276183; 15319427; 15383283; 15389287; 15456791; 15489227; 15489334; 15492226; 15494311; 15564333; 15601829; 15749833; 15761153; 15790681; 15802604; 15808510; 15837793; 15856005; 15856023; 15880043; 15951441; 16024783; 16046471; 16051665; 16082226; 16123045; 16126728; 16135815; 16177806; 16207722; 16267042; 16280329; 16286467; 16291755; 16319058; 16344560; 16365431; 16393995; 16424386; 16497931; 16547522; 16583354; 16603398; 16611882; 16728640; 16840786; 16906147; 16920630; 16938294; 16966325; 16982623; 16989899; 16997282; 16998237; 17000764; 17016640; 17047224; 17079871; 17114296; 17145747; 17182689; 17213322; 17237423; 17244613; 17287217; 17363905; 17363973; 17419715; 17446166; 17466952; 17568778; 17616684; 17684021; 17693255; 17703412; 17891179; 17939994; 17947699; 17962807; 17977820; 17997719; 18029348; 18037881; 18163512; 18180283; 18207244; 18260825; 18266324; 18266467; 18308615; 1831…
description: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
database cross reference: Ensembl:ENSG00000104365
database cross reference: HGNC:5960
database cross reference: HPRD:04462
database cross reference: MIM:603258
database cross reference: Vega:OTTHUMG00000164092

IL1A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IL-1A
alternative term: IL1
alternative term: IL1-ALPHA
alternative term: IL1F1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL1A
full name from nomenclature authority: interleukin 1, alpha
NCBI GeneID: 3552
gene map location: 2q14
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001660 (EC: IEA); GO_0005125 (EC: IMP, PMID: 2989698); GO_0005149 (EC: IEA); GO_0005507 (EC: IDA, PMID: 12746488); GO_0005515 (EC: IPI, PMID: 12746488); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 12746488); GO_0005615 (EC: IMP, PMID: 3493774); GO_0005829 (EC: IDA, PMID: 12746488); GO_0006915 (EC: TAS, PMID: 1924307); GO_0006954 (EC: TAS, PMID: 6209582); GO_0006955 (EC: IEA); GO_0008283 (EC: TAS, PMID: 6209582); GO_0008285 (EC: IDA, PMID: 3493774); GO_0010575 (EC: ISS); GO_0019221 (EC: IMP, PMID: 2989698); GO_0034605 (EC: IDA, PMID: 12746488); GO_0035234 (EC: IEA); GO_0045086 (EC: IMP, PMID: 2989698); GO_0045766 (EC: ISS); GO_0045840 (EC: IMP, PMID: 2989698); GO_0045944 (EC: IEA); GO_0046688 (EC: IDA, PMID: 12746488); GO_0050715 (EC: IDA, PMID: 1739124); GO_0051781 (EC: IEA); GO_0097192 (EC: IEA); GO_2001240 (EC: TAS, PMID: 10748004)
has PubMed association: PMID: 1548758; 1584804; 1675504; 1739124; 1905933; 1924307; 1993354; 2346741; 2536171; 2635664; 2783369; 2946959; 2989698; 2994016; 3281727; 3485152; 3486405; 3493774; 6209582; 7494249; 7499244; 7511078; 7526541; 7561697; 7566121; 7695626; 7706435; 7815507; 7818827; 7857652; 7878046; 8188271; 8346241; 8370968; 8436814; 8458986; 8621446; 8764000; 8892361; 8938574; 9108403; 9169134; 9185130; 9225992; 9658081; 9820540; 10441334; 10512743; 10625660; 10744718; 10748004; 10854325; 10860666; 10861041; 10953177; 10998424; 11065142; 11079552; 11093146; 11138328; 11145356; 11145836; 11233912; 11241561; 11264025; 11278614; 11350500; 11350506; 11423389; 11427627; 11436125; 11448121; 11453239; 11466363; 11554782; 11574262; 11640949; 11669478; 11703512; 11737511; 11774556; 11774564; 11777547; 11784248; 11790645; 11840488; 11858158; 11895290; 11895546; 11911995; 11921766; 11930657; 11940570; 11956022; 11991668; 11991722; 12028539; 12034804; 12037600; 12047332; 12051868; 12052540; 12052541; 12070246; 12082592; 12089333; 12100571; 12101079; 12102486; 12115161; 12115182; 12140751; 12149413; 12161036; 12164325; 12195069; 12209090; 12210881; 12212456; 12218254; 12220547; 12242547; 12362317; 12370389; 12390476; 12404162; 12425801; 12445219; 12445604; 12453471; 12477932; 12519748; 12528118; 12528119; 12530978; 12558814; 12558933; 12562360; 12598547; 12613995; 12622850; 12626603; 12631337; 12641660; 12651617; 12667716; 12673844; 12702109; 12710950; 12714264; 12729191; 12730545; 12737276; 12742380; 12746420; 12746488; 12749050; 12752101; 12752325; 12759172; 12782964; 12794386; 12801479; 12824054; 12869004; 12874528; 12890860; 12899665; 12901853; 12913118; 12928052; 12928381; 12930304; 12930389; 12931024; 12946945; 12947160; 12974682; 13679381; 14514232; 14533660; 14566095; 14584862; 14612453; 14633625; 14634838; 14639688; 14644395; 14656692; 14664464; 14672899; 14673470; 14674121; 14688369; 14693849; 14705223; 14735144; 14974822; 14983027; 14984963; 14986816; 14997019; 15007345; 15009111; …
description: interleukin 1, alpha
database cross reference: HGNC:5991
database cross reference: HPRD:00988
database cross reference: MIM:147760

IL1B
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IL-1
alternative term: IL1-BETA
alternative term: IL1F2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL1B
full name from nomenclature authority: interleukin 1, beta
NCBI GeneID: 3553
gene map location: 2q14
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: IMP); GO_0000187 (EC: IDA, PMID: 10748004); GO_0001660 (EC: IEA); GO_0001934 (EC: IDA, PMID: 10748004); GO_0001934 (EC: NAS, PMID: 16477012); GO_0002711 (EC: IC, PMID: 1919436); GO_0005125 (EC: IDA, PMID: 1919436); GO_0005125 (EC: IMP, PMID: 2989698); GO_0005149 (EC: NAS, PMID: 1919436); GO_0005576 (EC: IDA); GO_0005576 (EC: NAS, PMID: 1919436); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 12483741); GO_0005615 (EC: IMP, PMID: 3493774); GO_0005829 (EC: TAS); GO_0006915 (EC: TAS, PMID: 9218611); GO_0006954 (EC: IDA, PMID: 10748004); GO_0006954 (EC: NAS, PMID: 1919436); GO_0006955 (EC: IEA); GO_0007165 (EC: TAS, PMID: 10786823); GO_0007267 (EC: TAS, PMID: 2989698); GO_0007566 (EC: TAS, PMID: 16720713); GO_0008285 (EC: IDA, PMID: 3493774); GO_0009743 (EC: IEA); GO_0010575 (EC: IDA, PMID: 12958148); GO_0010575 (EC: ISS); GO_0010829 (EC: ISS, PMID: 16865359); GO_0014805 (EC: NAS, PMID: 16477012); GO_0019221 (EC: IDA, PMID: 10748004); GO_0019904 (EC: IPI, PMID: 16575408); GO_0030141 (EC: IEA); GO_0030213 (EC: IDA, PMID: 15100360); GO_0030593 (EC: IEA); GO_0030730 (EC: IDA, PMID: 19032770); GO_0030949 (EC: IC, PMID: 12958148); GO_0031622 (EC: ISS); GO_0031663 (EC: IDA); GO_0032308 (EC: ISS); GO_0032611 (EC: IEA); GO_0032725 (EC: IDA); GO_0032729 (EC: IDA); GO_0032755 (EC: TAS, PMID: 16865359); GO_0032757 (EC: IDA, PMID: 19524870); GO_0033129 (EC: NAS); GO_0033198 (EC: IEA); GO_0034116 (EC: IDA, PMID: 15100360); GO_0034116 (EC: NAS, PMID: 19281832); GO_0035066 (EC: NAS); GO_0035234 (EC: IEA); GO_0035505 (EC: IDA, PMID: 18390750); GO_0035690 (EC: IDA, PMID: 19158679); GO_0042102 (EC: IDA, PMID: 1919436); GO_0042346 (EC: IDA, PMID: 18390750); GO_0043122 (EC: IDA, PMID: 10748004); GO_0043123 (EC: IEA); GO_0043407 (EC: ISS, PMID: 16865359); GO_0043491 (EC: IMP); GO_0045080 (EC: IEA); GO_0045086 (EC: IMP, PMID: 2989698); GO_0045410 (EC: IEA); GO_0045429 (EC: IDA, PMID: 8383325); GO_0045766 (EC: ISS); GO_0045833 (EC: ISS, PMID: 16865359); GO_0045840 (EC: IMP, …
has PubMed association: PMID: 1548758; 1753956; 1835838; 1837236; 1905933; 1907279; 1918997; 1919001; 1919436; 1993354; 2001363; 2137098; 2372550; 2466831; 2536171; 2585509; 2602367; 2635664; 2898301; 2946959; 2954882; 2989698; 3259176; 3264123; 3281727; 3490654; 3493774; 6083565; 6209582; 7494249; 7511078; 7526541; 7561697; 7642516; 7706435; 7797510; 7815507; 7818827; 7878046; 7981229; 8188271; 8383325; 8432529; 8537091; 8663297; 8764000; 8852605; 8869030; 8892361; 8939574; 9062193; 9108403; 9169134; 9185130; 9218611; 9225992; 9230816; 9288832; 9378998; 9658081; 9714181; 9820540; 10339575; 10358063; 10383454; 10438928; 10512743; 10625660; 10744718; 10746728; 10748004; 10756100; 10779559; 10786823; 10854325; 10860666; 10964543; 11023482; 11051551; 11057907; 11076651; 11079552; 11083263; 11093146; 11127488; 11138328; 11145836; 11171832; 11211945; 11226333; 11233912; 11238007; 11241561; 11260714; 11264025; 11278614; 11350500; 11350506; 11380940; 11422336; 11423389; 11427627; 11448121; 11466363; 11476790; 11481169; 11498264; 11500085; 11506478; 11527622; 11531943; 11574262; 11578018; 11579484; 11600466; 11606496; 11640949; 11641511; 11665666; 11669478; 11686217; 11686480; 11703512; 11704656; 11737511; 11751881; 11751921; 11756575; 11762793; 11770040; 11774564; 11777965; 11784248; 11790645; 11801594; 11806247; 11838837; 11840488; 11847219; 11849463; 11851889; 11853544; 11857060; 11858158; 11858187; 11868623; 11876744; 11895290; 11896542; 11898000; 11920321; 11921766; 11930657; 11950481; 11955925; 11958432; 11981835; 11991722; 12009575; 12021045; 12028539; 12031914; 12034804; 12038885; 12039524; 12042033; 12044341; 12050157; 12050395; 12052540; 12052541; 12067976; 12070246; 12077278; 12082592; 12089333; 12093792; 12095061; 12100571; 12101072; 12102486; 12105837; 12114904; 12115161; 12115182; 12117921; 12117953; 12117969; 12121221; 12121679; 12133437; 12133438; 12133467; 12140751; 12149413; 12161036; 12161099; 12163271; 12164325; 12165808; 12184914; 12191486; 12193665; 12195069; 12210881; 122124…
description: interleukin 1, beta
database cross reference: Ensembl:ENSG00000125538
database cross reference: HGNC:5992
database cross reference: HPRD:00985
database cross reference: MIM:147720
database cross reference: Vega:OTTHUMG00000131344

IL3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IL-3
alternative term: MCGF
alternative term: MULTI-CSF
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL3
full name from nomenclature authority: interleukin 3
NCBI GeneID: 3562
gene map location: 5q31.1
modification date: 20140409
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005125 (EC: IEA); GO_0005135 (EC: TAS, PMID: 2544122); GO_0005576 (EC: TAS); GO_0005615 (EC: ISS); GO_0006955 (EC: IEA); GO_0007267 (EC: TAS, PMID: 3497400); GO_0007399 (EC: TAS, PMID: 9736740); GO_0008083 (EC: IEA); GO_0008284 (EC: ISS); GO_0035162 (EC: IDA); GO_0042523 (EC: IDA, PMID: 9722506); GO_0045740 (EC: IDA, PMID: 9722506); GO_0050731 (EC: ISS)
has PubMed association: PMID: 1833064; 2268499; 2544122; 3127463; 3489530; 3497400; 3497843; 7642615; 7957082; 8018916; 8516290; 8649415; 8676386; 9030599; 9113989; 9209414; 9278420; 9551928; 9629242; 9659156; 9722506; 9736740; 10477722; 10677502; 11179015; 11399510; 11486081; 11700046; 11714768; 11763346; 11861295; 11994280; 12002675; 12055233; 12089333; 12093816; 12135758; 12165512; 12423306; 12477932; 12612065; 12759409; 12855588; 12884288; 12943658; 14551608; 14564341; 14615378; 14628073; 14675189; 14755254; 15060062; 15372022; 15372320; 15489334; 15576295; 15585837; 15878977; 15988318; 16785501; 17179997; 17207965; 17273755; 17362254; 17507237; 17541278; 17624239; 17703412; 18633131; 18676680; 18692472; 18768389; 18804346; 18826654; 18829683; 19074885; 19131452; 19158269; 19170196; 19201898; 19247692; 19258923; 19262575; 19529981; 19578876; 19625176; 19692168; 19730683; 19829692; 19845895; 19913121; 20147630; 20210668; 20237496; 20332709; 20381581; 20424473; 20452482; 20453000; 20472554; 20503287; 20516062; 20628086; 20673868; 20738848; 20800603; 20964623; 21071541; 21102463; 21168724; 21224257; 21262803; 21506110; 21643009; 22321809; 22412388; 22515947; 23024272; 23128233; 23226269; 23726808
description: interleukin 3
database cross reference: Ensembl:ENSG00000164399
database cross reference: HGNC:6011
database cross reference: HPRD:00987
database cross reference: MIM:147740
database cross reference: Vega:OTTHUMG00000059640

IL4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BCGF-1
alternative term: BCGF1
alternative term: BSF-1
alternative term: BSF1
alternative term: IL-4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL4
full name from nomenclature authority: interleukin 4
NCBI GeneID: 3565
gene map location: 5q31.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002227 (EC: IEA); GO_0002296 (EC: IEA); GO_0002674 (EC: IEA); GO_0002677 (EC: IEA); GO_0005125 (EC: IEA); GO_0005136 (EC: TAS, PMID: 11418631); GO_0005515 (EC: IPI, PMID: 10219247); GO_0005615 (EC: TAS, PMID: 11418631); GO_0006935 (EC: TAS, PMID: 10725748); GO_0006955 (EC: TAS, PMID: 3016727); GO_0006968 (EC: TAS, PMID: 10725748); GO_0007565 (EC: IEA); GO_0007584 (EC: IEA); GO_0008083 (EC: NAS, PMID: 11418631); GO_0008203 (EC: ISS, PMID: 11971948); GO_0009897 (EC: IEA); GO_0010155 (EC: IEA); GO_0014070 (EC: IEA); GO_0030183 (EC: TAS, PMID: 11418631); GO_0030890 (EC: ISS); GO_0031296 (EC: IEA); GO_0032733 (EC: IEA); GO_0032736 (EC: IDA, PMID: 19346497); GO_0034097 (EC: IEA); GO_0035745 (EC: IDA); GO_0042092 (EC: TAS, PMID: 11676128); GO_0042102 (EC: ISS); GO_0042104 (EC: IEA); GO_0042325 (EC: ISS); GO_0042493 (EC: IEA); GO_0042523 (EC: IEA); GO_0042832 (EC: IEA); GO_0043031 (EC: IEA); GO_0043066 (EC: ISS); GO_0045019 (EC: IEA); GO_0045064 (EC: IEA); GO_0045080 (EC: IEA); GO_0045189 (EC: TAS, PMID: 11967989); GO_0045191 (EC: TAS, PMID: 11418631); GO_0045348 (EC: ISS); GO_0045471 (EC: IEA); GO_0045582 (EC: IDA); GO_0045671 (EC: ISS); GO_0045892 (EC: IDA, PMID: 18579517); GO_0045893 (EC: IDA, PMID: 18579517); GO_0045944 (EC: ISS); GO_0048295 (EC: ISS); GO_0048304 (EC: ISS); GO_0050776 (EC: ISS); GO_0051091 (EC: IEA); GO_0071288 (EC: IEA); GO_0097028 (EC: IDA); GO_0097192 (EC: IEA); GO_2000320 (EC: IEA); GO_2001237 (EC: IEA)
has PubMed association: PMID: 1197194; 1346976; 1400355; 1511746; 1567880; 1567881; 1569578; 1609277; 1932028; 1946344; 1993171; 2535858; 3016727; 3257560; 7523014; 7589092; 7664036; 7695626; 7806280; 7963560; 8151703; 8266078; 8516290; 8602263; 8603435; 8609418; 8764000; 9113989; 9130521; 9130652; 9334723; 9799097; 9856950; 10219247; 10438901; 10473513; 10623799; 10710213; 10714547; 10725748; 10753117; 10853974; 11023480; 11035134; 11122213; 11149986; 11167377; 11233912; 11258628; 11258696; 11294568; 11298547; 11315919; 11316066; 11316069; 11320251; 11350513; 11396683; 11418631; 11466338; 11496248; 11502824; 11528525; 11587989; 11676128; 11678851; 11704810; 11728464; 11777980; 11786020; 11811777; 11841848; 11842291; 11872954; 11877044; 11881490; 11886168; 11897522; 11897999; 11907068; 11920312; 11922633; 11930331; 11950517; 11953141; 11960309; 11967989; 11968047; 11971948; 11980568; 11994288; 12020266; 12030894; 12039414; 12063527; 12066847; 12072494; 12082592; 12089714; 12102661; 12105273; 12107748; 12115161; 12121273; 12124654; 12133437; 12144536; 12161424; 12162874; 12165514; 12207324; 12220533; 12358844; 12363051; 12366695; 12368275; 12402189; 12420205; 12426308; 12435565; 12441140; 12442007; 12470598; 12477932; 12479817; 12504082; 12508140; 12508786; 12509382; 12513914; 12515722; 12517954; 12525574; 12542496; 12552499; 12574355; 12578333; 12587822; 12595908; 12600829; 12613995; 12626590; 12660931; 12663328; 12667657; 12687213; 12687247; 12689929; 12694433; 12700447; 12715242; 12738651; 12748907; 12753568; 12813360; 12851716; 12877559; 12884288; 12897746; 12900808; 12902508; 12911786; 12940513; 12944981; 12973929; 14499500; 14503851; 14522096; 14523823; 14530362; 14551608; 14561191; 14568946; 14583474; 14610476; 14634065; 14634100; 14652008; 14654080; 14675394; 14681304; 14688371; 14692664; 14693849; 14697238; 14697936; 14725568; 14729510; 14746805; 14764715; 14767810; 14983029; 14986816; 15001290; 15004182; 15007352; 15013759; 15014952; 15021309; 15041089; 15042002; 15051937; 1505790…
description: interleukin 4
database cross reference: Ensembl:ENSG00000113520
database cross reference: HGNC:6014
database cross reference: HPRD:00989
database cross reference: MIM:147780
database cross reference: Vega:OTTHUMG00000059724

IL4R
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD124
alternative term: IL-4RA
alternative term: IL4RA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL4R
full name from nomenclature authority: interleukin 4 receptor
NCBI GeneID: 3566
NCBI LocusTag: 582J2.1
gene map location: 16p12.1-p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002532 (EC: IEA); GO_0004913 (EC: TAS, PMID: 2307934); GO_0005057 (EC: TAS, PMID: 2307934); GO_0005515 (EC: IPI, PMID: 10219247); GO_0005615 (EC: IEA); GO_0005887 (EC: TAS, PMID: 2307934); GO_0006955 (EC: TAS, PMID: 2307934); GO_0007165 (EC: TAS, PMID: 2307934); GO_0030728 (EC: IEA); GO_0035556 (EC: TAS, PMID: 2307934); GO_0035771 (EC: TAS, PMID: 2307934); GO_0042127 (EC: IEA); GO_0042832 (EC: IEA); GO_0043032 (EC: IEA); GO_0043235 (EC: IDA); GO_0043560 (EC: RCA, PMID: 19641626); GO_0043627 (EC: IEA); GO_0045626 (EC: IEA); GO_0045630 (EC: IEA); GO_0090197 (EC: IEA)
has PubMed association: PMID: 1617647; 1679753; 2114443; 2278997; 2307934; 7518439; 7538655; 7721895; 7775445; 8101483; 8124718; 8125298; 8222329; 8266076; 8266078; 8599766; 8609418; 8624803; 8804422; 8816495; 8891114; 8910586; 8916957; 8954948; 9070874; 9190938; 9392697; 9515586; 9545332; 9620765; 9651359; 9670964; 9697832; 9761767; 10201973; 10219247; 10233717; 10341317; 10358772; 10369419; 10390422; 10421786; 10486269; 10493829; 10590262; 10652211; 10677312; 10809862; 10856136; 11035134; 11164908; 11233912; 11285129; 11354638; 11491529; 11513543; 11528525; 11544427; 11678851; 11709756; 11714803; 11773030; 11786020; 11801567; 11811777; 11922633; 11991671; 12020266; 12047364; 12047365; 12082592; 12100043; 12115161; 12133952; 12133990; 12171893; 12207328; 12242343; 12401728; 12420205; 12422339; 12442007; 12454749; 12459556; 12477932; 12508140; 12558814; 12594065; 12743452; 12748907; 12753568; 12871855; 12897746; 12900808; 12940513; 12960323; 12973929; 14523823; 14615367; 14745651; 14984008; 15005726; 15007345; 15007352; 15021309; 15057902; 15122773; 15161635; 15170937; 15194285; 15298559; 15356556; 15361128; 15367225; 15479272; 15497451; 15521376; 15526032; 15564773; 15566952; 15660293; 15661890; 15712015; 15733644; 15737301; 15842262; 15969687; 15981567; 16024651; 16046318; 16100774; 16169070; 16184405; 16189667; 16226465; 16264039; 16280132; 16313303; 16313681; 16344560; 16387595; 16403098; 16503977; 16538488; 16551465; 16600026; 16613701; 16625214; 16640778; 16646030; 16681592; 16699452; 16750991; 16757160; 16842617; 16867043; 16914241; 16917945; 16938461; 16950281; 16961803; 17001290; 17006724; 17045041; 17083349; 17091279; 17115186; 17121586; 17143971; 17152005; 17170387; 17179726; 17201240; 17209513; 17257312; 17258448; 17284225; 17291854; 17303794; 17315188; 17362266; 17420820; 17444864; 17523428; 17536219; 17548690; 17586032; 17600229; 17627763; 17688234; 17703412; 17714919; 17823973; 17889143; 17900677; 17901851; 17988330; 18006935; 18031948; 18095154; 18179773; 18243101; 18263811…
description: interleukin 4 receptor
database cross reference: Ensembl:ENSG00000077238
database cross reference: HGNC:6015
database cross reference: HPRD:00990
database cross reference: MIM:147781
database cross reference: Vega:OTTHUMG00000097015

IL6
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BSF2
alternative term: HGF
alternative term: HSF
alternative term: IFNB2
alternative term: IL-6
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL6
full name from nomenclature authority: interleukin 6
NCBI GeneID: 3569
gene map location: 7p21
modification date: 20140409
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001781 (EC: IDA, PMID: 7595060); GO_0002384 (EC: IDA, PMID: 2444978); GO_0002384 (EC: TAS, PMID: 12832423); GO_0002446 (EC: IC, PMID: 16034137); GO_0002548 (EC: IC, PMID: 10510402); GO_0002675 (EC: IDA, PMID: 2444978); GO_0002690 (EC: IC, PMID: 16034137); GO_0005125 (EC: IDA, PMID: 3023045); GO_0005125 (EC: NAS, PMID: 10443688); GO_0005138 (EC: IPI, PMID: 12829785); GO_0005138 (EC: IPI, Qualifier: contributes_to, PMID: 12829785); GO_0005138 (EC: NAS, PMID: 1883960); GO_0005515 (EC: IPI, PMID: 11238858); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 10443688); GO_0005896 (EC: IDA, PMID: 12829785); GO_0006469 (EC: IEA); GO_0006953 (EC: TAS, PMID: 12832423); GO_0006954 (EC: IDA, PMID: 10443688); GO_0006959 (EC: IC, PMID: 3491322); GO_0007568 (EC: IEA); GO_0008083 (EC: IDA, PMID: 12643274); GO_0008284 (EC: IDA, PMID: 2261637); GO_0008284 (EC: IMP, PMID: 18719127); GO_0008285 (EC: IEA); GO_0008360 (EC: IEA); GO_0009408 (EC: IEA); GO_0009409 (EC: IEA); GO_0009612 (EC: IEA); GO_0009897 (EC: IEA); GO_0010574 (EC: IDA, PMID: 8557680); GO_0010888 (EC: NAS, PMID: 16464856); GO_0016049 (EC: IEA); GO_0019221 (EC: IDA, PMID: 12643274); GO_0030168 (EC: TAS, PMID: 7831669); GO_0031000 (EC: IEA); GO_0031018 (EC: ISS, PMID: 18719127); GO_0031175 (EC: IMP, PMID: 3264880); GO_0031667 (EC: IEA); GO_0032494 (EC: IEP, PMID: 16034137); GO_0032496 (EC: IEA); GO_0032722 (EC: IDA, PMID: 10510402); GO_0032722 (EC: IMP, PMID: 16034137); GO_0032755 (EC: IDA, PMID: 10510402); GO_0032868 (EC: IEA); GO_0032966 (EC: IDA, PMID: 12419823); GO_0033138 (EC: IDA, PMID: 7508917); GO_0033160 (EC: IEA); GO_0042102 (EC: IDA, PMID: 3130269); GO_0042493 (EC: IEA); GO_0042517 (EC: IDA, PMID: 12643274); GO_0042832 (EC: IEA); GO_0043065 (EC: IDA, PMID: 9949178); GO_0043066 (EC: IDA, PMID: 7595060); GO_0043154 (EC: IEA); GO_0043200 (EC: IEA); GO_0043410 (EC: IDA, PMID: 12419823); GO_0045079 (EC: ISS); GO_0045188 (EC: IEA); GO_0045429 (EC: IEA); GO_0045454 (EC: IEA); GO_0045599 (EC: NAS, PMID: 16464856); GO_…
has PubMed association: PMID: 1113021; 1291290; 1346976; 1610348; 1656094; 1883960; 1918997; 2037043; 2261637; 2444978; 2472117; 2610854; 2680567; 2788034; 2789513; 2829354; 2906047; 3023045; 3130269; 3264880; 3266463; 3279116; 3294161; 3320204; 3491322; 3500852; 3538015; 3758081; 7494249; 7508917; 7511078; 7511596; 7523444; 7526541; 7536422; 7553888; 7595060; 7656270; 7693046; 7704970; 7749983; 7803268; 7815507; 7831669; 7851440; 7986583; 8018916; 8086129; 8113688; 8179923; 8190832; 8206884; 8247028; 8510564; 8555185; 8557680; 8764000; 8806809; 8938574; 9094636; 9108403; 9118960; 9159484; 9169458; 9225992; 9378998; 9658081; 9671211; 9792375; 9927325; 9949178; 10358063; 10388525; 10415019; 10443688; 10510402; 10657672; 10671302; 10775602; 10777583; 10925276; 10964543; 11028446; 11040178; 11054276; 11072134; 11072751; 11116068; 11145851; 11167813; 11196676; 11196678; 11199329; 11204808; 11212160; 11224491; 11233912; 11238858; 11266856; 11266927; 11266928; 11267084; 11282548; 11312376; 11315919; 11316066; 11342474; 11354638; 11355017; 11371414; 11391238; 11397324; 11404167; 11448119; 11485024; 11500818; 11517385; 11520812; 11544427; 11544434; 11544437; 11557672; 11574109; 11640949; 11687509; 11689614; 11692078; 11703956; 11713964; 11716039; 11728144; 11733366; 11751408; 11758653; 11774563; 11777983; 11781191; 11788581; 11792588; 11794009; 11801594; 11818668; 11820460; 11847482; 11849463; 11853279; 11855786; 11858187; 11862386; 11884027; 11884029; 11884401; 11884403; 11889177; 11895465; 11902285; 11906646; 11914754; 11918227; 11919083; 11922913; 11949822; 11950481; 11950697; 11956023; 11959895; 11960393; 11961304; 11966578; 11981433; 11983287; 11984595; 11988246; 11988625; 11990931; 11992567; 12000745; 12012622; 12027404; 12031914; 12032172; 12036196; 12038454; 12047360; 12050565; 12051396; 12067898; 12070032; 12080442; 12082590; 12082592; 12086705; 12089333; 12089714; 12091348; 12095061; 12096924; 12096927; 12107724; 12110411; 12114287; 12117737; 12117921; 12117953; 12121679; 12133353; 12140…
description: interleukin 6
database cross reference: Ensembl:ENSG00000136244
database cross reference: HGNC:6018
database cross reference: HPRD:00970
database cross reference: MIM:147620
database cross reference: Vega:OTTHUMG00000023178

IL6R
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD126
alternative term: IL-6R-1
alternative term: IL-6RA
alternative term: IL6Q
alternative term: IL6RA
alternative term: IL6RQ
alternative term: gp80
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL6R
full name from nomenclature authority: interleukin 6 receptor
NCBI GeneID: 3570
gene map location: 1q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002384 (EC: TAS, PMID: 12832423); GO_0002446 (EC: IC, PMID: 16034137); GO_0002548 (EC: IC, PMID: 10510402); GO_0002690 (EC: IC, PMID: 16034137); GO_0002690 (EC: TAS, PMID: 15100312); GO_0004897 (EC: IMP, Qualifier: contributes_to, PMID: 12643274); GO_0004915 (EC: IDA, Qualifier: contributes_to, PMID: 2261637); GO_0005138 (EC: IPI, Qualifier: contributes_to, PMID: 12829785); GO_0005515 (EC: IPI, PMID: 11238858); GO_0005576 (EC: IDA, PMID: 12748171); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 12419823); GO_0005886 (EC: TAS); GO_0005896 (EC: IDA, PMID: 12829785); GO_0006953 (EC: TAS, PMID: 12832423); GO_0008284 (EC: IDA, PMID: 2261637); GO_0008284 (EC: IMP, PMID: 18719127); GO_0009986 (EC: IEA); GO_0010536 (EC: IDA, PMID: 12419823); GO_0016323 (EC: IEA); GO_0016324 (EC: IDA, PMID: 16034137); GO_0019221 (EC: IDA, PMID: 2261637); GO_0019899 (EC: IPI, PMID: 12748171); GO_0019981 (EC: IPI, PMID: 12829785); GO_0031018 (EC: IC, PMID: 18719127); GO_0031018 (EC: IMP, PMID: 18719127); GO_0032717 (EC: IEP, PMID: 16034137); GO_0032722 (EC: IDA, PMID: 10510402); GO_0032755 (EC: IDA, PMID: 10510402); GO_0032966 (EC: IDA, PMID: 12419823); GO_0034097 (EC: IDA, PMID: 2261637); GO_0042517 (EC: IMP, PMID: 12643274); GO_0042803 (EC: IPI, PMID: 12633863); GO_0043410 (EC: IDA, PMID: 12419823); GO_0045669 (EC: TAS, PMID: 12372336); GO_0048661 (EC: IDA, PMID: 10510402); GO_0050731 (EC: IDA, PMID: 11884403); GO_0050829 (EC: IEP, PMID: 16034137); GO_0050830 (EC: IEP, PMID: 16034137); GO_0051092 (EC: IDA, Qualifier: NOT, PMID: 12419823); GO_0070102 (EC: IMP, PMID: 12643274); GO_0070119 (EC: IPI, PMID: 12643274); GO_0070120 (EC: IMP, PMID: 12643274); GO_0097191 (EC: TAS, PMID: 15100312)
has PubMed association: PMID: 1281789; 1381187; 1872801; 1889804; 2112585; 2157217; 2261637; 2529343; 2788034; 3136546; 8056053; 8125298; 8265649; 8428753; 8450224; 8467812; 8889549; 9169421; 9927325; 10066782; 10462375; 10510402; 10777583; 10785334; 10982829; 11017875; 11238858; 11884403; 12002769; 12008038; 12079407; 12372336; 12412787; 12414855; 12419823; 12445803; 12461182; 12472176; 12477932; 12553038; 12553555; 12574959; 12633863; 12643274; 12748171; 12748876; 12789531; 12829785; 12832423; 12857602; 12917504; 14557255; 14592826; 14718574; 15041717; 15063602; 15100312; 15166129; 15213442; 15284182; 15297310; 15306846; 15456942; 15489334; 15561970; 15562008; 15579373; 15625895; 15641051; 15816827; 15837717; 15857508; 15895091; 16034137; 16127269; 16270750; 16372246; 16557588; 16710414; 16731080; 16794539; 16817825; 16899024; 16912152; 16973585; 17151125; 17160948; 17310346; 17313958; 17346257; 17357077; 17519976; 17570254; 17619842; 17652155; 17671508; 17703412; 17898129; 17903307; 17908769; 17984249; 18065760; 18276608; 18320358; 18439548; 18464913; 18490707; 18508242; 18538149; 18543249; 18676680; 18719127; 18781131; 18784373; 18818748; 18852330; 18853133; 18971377; 18980999; 19019335; 19026125; 19088723; 19124510; 19170196; 19258923; 19277666; 19280716; 19336475; 19396608; 19406470; 19420002; 19422646; 19453261; 19495883; 19503017; 19505916; 19527514; 19567438; 19573080; 19625176; 19633828; 19665805; 19671870; 19692168; 19713205; 19733878; 19773279; 19773451; 19790045; 19877065; 19913121; 19914334; 19926672; 19966016; 20017315; 20026129; 20031577; 20083667; 20140262; 20145925; 20157327; 20159251; 20186139; 20197062; 20237496; 20379614; 20438838; 20452482; 20453000; 20463041; 20484876; 20503287; 20551110; 20568250; 20599261; 20600579; 20628086; 20661738; 20673868; 20698883; 20727736; 20800603; 20811626; 20823887; 20839491; 20856253; 20951753; 20974296; 21159831; 21173340; 21196890; 21220034; 21229891; 21255427; 21282511; 21295508; 21300955; 21401300; 21490132; 21496483; 21515913; 217…
description: interleukin 6 receptor
database cross reference: Ensembl:ENSG00000160712
database cross reference: HGNC:6019
database cross reference: HPRD:01000
database cross reference: MIM:147880
database cross reference: Vega:OTTHUMG00000036073

IL8
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CXCL8
alternative term: GCP-1
alternative term: GCP1
alternative term: LECT
alternative term: LUCT
alternative term: LYNAP
alternative term: MDNCF
alternative term: MONAP
alternative term: NAF
alternative term: NAP-1
alternative term: NAP1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL8
full name from nomenclature authority: interleukin 8
NCBI GeneID: 3576
gene map location: 4q13-q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001525 (EC: TAS, PMID: 11483765); GO_0002237 (EC: IDA, PMID: 19912257); GO_0005153 (EC: IPI, PMID: 1840701); GO_0005515 (EC: IPI, PMID: 10880251); GO_0005576 (EC: TAS); GO_0005615 (EC: IEA); GO_0006928 (EC: TAS, PMID: 10820279); GO_0006935 (EC: TAS, PMID: 12782716); GO_0006954 (EC: TAS, PMID: 11483765); GO_0006955 (EC: IEA); GO_0006987 (EC: TAS); GO_0007050 (EC: IDA, PMID: 11564821); GO_0007165 (EC: TAS, PMID: 10820279); GO_0007186 (EC: TAS, PMID: 8381837); GO_0008009 (EC: TAS, PMID: 12782716); GO_0008285 (EC: TAS, PMID: 9551928); GO_0019722 (EC: TAS, PMID: 11877327); GO_0030155 (EC: IDA, PMID: 2007144); GO_0030593 (EC: IGI, PMID: 11564821); GO_0030968 (EC: TAS); GO_0031623 (EC: IDA, PMID: 10734056); GO_0034976 (EC: IDA); GO_0035556 (EC: IDA, PMID: 10734056); GO_0042119 (EC: TAS, PMID: 11483765); GO_0044267 (EC: TAS); GO_0044344 (EC: IEP, PMID: 9407497); GO_0045091 (EC: IDA, PMID: 11483765); GO_0045744 (EC: IDA, PMID: 10734056); GO_0048566 (EC: IEP); GO_0050930 (EC: IGI, PMID: 11564821); GO_0071222 (EC: IDA, PMID: 19912257); GO_0071347 (EC: IEP, PMID: 9407497); GO_0071356 (EC: IEP, PMID: 9407497); GO_0090023 (EC: TAS, PMID: 1699135)
has PubMed association: PMID: 1281554; 1391327; 1639201; 1673289; 1699135; 1840701; 1895676; 1988949; 2005614; 2007144; 2145175; 2170450; 2182630; 2184886; 2200751; 2212672; 2456256; 2523801; 2555418; 2648135; 2648569; 2655583; 2659722; 2663993; 2664463; 2681204; 2834384; 2953813; 3057503; 3223947; 3260265; 3279957; 3322281; 3480540; 7673721; 7695626; 8077676; 8081002; 8381837; 8626516; 8631339; 8662698; 8663179; 8702798; 8995686; 9141135; 9323208; 9363947; 9378998; 9407497; 9464567; 9510190; 9551928; 9659156; 9828130; 9921412; 10343098; 10361232; 10368283; 10376933; 10491366; 10620615; 10707023; 10734056; 10764593; 10775602; 10820279; 10823949; 10880251; 10881932; 10929056; 10982368; 10985244; 10985253; 11023497; 11069235; 11083887; 11160671; 11226151; 11328384; 11483765; 11509627; 11564821; 11756416; 11784713; 11814358; 11854210; 11855786; 11868823; 11876744; 11877327; 11884401; 11884459; 11888846; 11896938; 11910304; 11911801; 11940655; 11950481; 11956621; 11960393; 11964077; 11966578; 11973337; 11978786; 11989790; 11999552; 12021366; 12027404; 12033786; 12034575; 12039947; 12055238; 12055326; 12056817; 12060853; 12067976; 12081586; 12089333; 12090473; 12091490; 12093676; 12096924; 12096927; 12100025; 12101072; 12115500; 12117737; 12117926; 12117969; 12117995; 12123753; 12126643; 12133438; 12139952; 12149127; 12150710; 12151316; 12151344; 12163591; 12164325; 12165085; 12169092; 12169272; 12186702; 12186913; 12187073; 12195386; 12223528; 12225945; 12239630; 12359770; 12364441; 12366401; 12370346; 12382118; 12384994; 12388718; 12388959; 12391099; 12393171; 12410798; 12415593; 12453441; 12477932; 12480084; 12485855; 12496258; 12502445; 12513912; 12520365; 12524080; 12529421; 12530093; 12533683; 12543081; 12547728; 12548717; 12565901; 12573991; 12576442; 12584113; 12586630; 12594001; 12594058; 12615831; 12626597; 12628493; 12632066; 12633940; 12634636; 12637525; 12646250; 12653788; 12654635; 12654834; 12660426; 12662377; 12702497; 12707271; 12720537; 12727029; 12729795; 12738388; 12744776; …
description: interleukin 8
database cross reference: Ensembl:ENSG00000169429
database cross reference: HGNC:6025
database cross reference: HPRD:00909
database cross reference: MIM:146930
database cross reference: Vega:OTTHUMG00000151316

CXCR1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: C-C
alternative term: C-C-CKR-1
alternative term: CD128
alternative term: CD181
alternative term: CDw128a
alternative term: CKR-1
alternative term: CMKAR1
alternative term: IL8R1
alternative term: IL8RA
alternative term: IL8RBA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CXCR1
full name from nomenclature authority: chemokine (C-X-C motif) receptor 1
NCBI GeneID: 3577
gene map location: 2q35
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002407 (EC: TAS, PMID: 16621978); GO_0004918 (EC: IDA, PMID: 10734056); GO_0004930 (EC: TAS, PMID: 8381837); GO_0004950 (EC: TAS, PMID: 1840701); GO_0005886 (EC: TAS); GO_0006935 (EC: TAS, PMID: 10725748); GO_0006954 (EC: TAS, PMID: 10725748); GO_0007166 (EC: IDA, PMID: 10734056); GO_0007186 (EC: TAS, PMID: 8381837); GO_0016020 (EC: TAS, PMID: 10725748); GO_0016021 (EC: IEA); GO_0019959 (EC: IPI, PMID: 11564821); GO_0031623 (EC: IDA, PMID: 10734056); GO_0038112 (EC: IDA, PMID: 10734056); GO_0070098 (EC: TAS, PMID: 1840701)
has PubMed association: PMID: 1303245; 1379593; 1427896; 1840701; 2834384; 7527448; 7650389; 7829970; 7868904; 7929358; 8077663; 8195702; 8316840; 8381837; 8384312; 8486366; 8500355; 8662698; 8702798; 8903513; 9260277; 9692902; 9843397; 10368283; 10570306; 10593335; 10725748; 10734056; 10843722; 11007922; 11196695; 11397869; 11564821; 12002274; 12055238; 12077146; 12239185; 12442335; 12477932; 12535747; 12576754; 12628493; 12651900; 12870115; 14688334; 14713106; 15028716; 15133028; 15265017; 15292066; 15454487; 15489334; 15545821; 15556942; 15579377; 15598788; 15618253; 15641067; 15764156; 15772681; 15793866; 15815621; 15902300; 15946947; 16098254; 16205979; 16406804; 16411061; 16500343; 16621978; 16679868; 16897191; 16950632; 16987681; 17026468; 17169533; 17204468; 17207897; 17295203; 17296422; 17360650; 17361014; 17596666; 17604950; 17672867; 17786197; 17876799; 17996233; 18025257; 18059279; 18240029; 18577758; 18667484; 18676680; 18676870; 18818748; 19012493; 19019335; 19118103; 19151925; 19401689; 19423540; 19505916; 19527514; 19573080; 19585580; 19625176; 19634663; 19681642; 19692168; 19735481; 19773279; 19773451; 19890050; 19913121; 20016196; 20016852; 20044480; 20089160; 20237496; 20406964; 20438785; 20452482; 20453000; 20628086; 20630874; 20811626; 21036625; 21042230; 21048114; 21297633; 21323370; 21452410; 21555225; 21749879; 21915051; 21988832; 21989491; 22019593; 22024025; 22051099; 22076427; 22088968; 22152684; 22171941; 22174157; 22242662; 22262769; 22325052; 22482416; 22489883; 22563025; 22626766; 22763101; 22904195; 22936990; 23086146; 23128233; 23349885; 23396733; 23470693; 23525041; 23904157; 23912333; 24161763
description: chemokine (C-X-C motif) receptor 1
database cross reference: Ensembl:ENSG00000163464
database cross reference: HGNC:6026
database cross reference: HPRD:00908
database cross reference: MIM:146929
database cross reference: Vega:OTTHUMG00000133108

CXCR2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD182
alternative term: CDw128b
alternative term: CMKAR2
alternative term: IL8R2
alternative term: IL8RA
alternative term: IL8RB
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CXCR2
full name from nomenclature authority: chemokine (C-X-C motif) receptor 2
NCBI GeneID: 3579
gene map location: 2q35
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002407 (EC: TAS, PMID: 16621978); GO_0002438 (EC: IEA); GO_0004871 (EC: IDA, PMID: 10438939); GO_0004918 (EC: IDA, PMID: 10820279); GO_0005515 (EC: IPI); GO_0005622 (EC: IDA, PMID: 10878382); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 10438939); GO_0006935 (EC: IDA, PMID: 10725748); GO_0006954 (EC: TAS, PMID: 9725262); GO_0006968 (EC: IDA, PMID: 10725748); GO_0007165 (EC: IDA, PMID: 10820279); GO_0007166 (EC: IDA, PMID: 10734056); GO_0007200 (EC: IDA, PMID: 10438939); GO_0007204 (EC: IEA); GO_0008284 (EC: IDA, PMID: 10438939); GO_0009986 (EC: IDA, PMID: 10878382); GO_0010666 (EC: IEA); GO_0016020 (EC: IDA, PMID: 10725748); GO_0016494 (EC: IDA, PMID: 10878382); GO_0019959 (EC: IPI, PMID: 1840701); GO_0030593 (EC: IDA, PMID: 10820279); GO_0030901 (EC: IEA); GO_0031623 (EC: IDA, PMID: 10734056); GO_0033030 (EC: IEA); GO_0038112 (EC: IDA, PMID: 10820279); GO_0042119 (EC: IDA, PMID: 10878382); GO_0042629 (EC: IDA, PMID: 9725262); GO_0043117 (EC: IEA); GO_0045766 (EC: IEA); GO_0070098 (EC: IDA, PMID: 10878382); GO_0072173 (EC: IEA); GO_0090023 (EC: IEA)
has PubMed association: PMID: 1303245; 1379593; 1427896; 1840701; 1891716; 2834384; 7512557; 7829970; 7929358; 8036519; 8194768; 8195702; 8294449; 8316840; 8384312; 8550564; 8626516; 8662698; 8702798; 8940121; 9058825; 9079638; 9260277; 9464567; 9651375; 9692902; 9725262; 9843397; 10438939; 10593335; 10688807; 10725748; 10734056; 10820279; 10878382; 10881932; 10943863; 11007922; 11023990; 11138777; 11170396; 11196695; 11278485; 11397869; 11435493; 11524231; 11751889; 11818437; 12164325; 12176324; 12239185; 12442335; 12453441; 12477932; 12496258; 12606476; 12620646; 12628493; 12633567; 12870115; 12888558; 12975484; 14713106; 14967163; 15004234; 15028716; 15063762; 15265017; 15358660; 15364949; 15452121; 15454487; 15479720; 15489334; 15545821; 15598788; 15618253; 15626158; 15630732; 15772681; 15793866; 15946947; 16086366; 16098254; 16260092; 16272353; 16344560; 16406804; 16411061; 16621978; 16679868; 16702372; 16793206; 16897191; 16987681; 16990258; 17003486; 17142783; 17204468; 17272812; 17295203; 17360650; 17435771; 17604950; 17630697; 17672867; 17703412; 17709521; 17939034; 17949231; 17996233; 18025257; 18199703; 18208820; 18240029; 18244953; 18292390; 18307412; 18462836; 18555777; 18577758; 18633131; 18676870; 18755694; 18780829; 18852457; 19010874; 19012493; 19026125; 19035451; 19057948; 19067586; 19118103; 19147552; 19151925; 19155217; 19170196; 19258923; 19401689; 19423540; 19435808; 19435811; 19549892; 19573080; 19585580; 19634663; 19750480; 19773279; 19887480; 19890050; 19904283; 19913121; 20005738; 20016196; 20016852; 20018298; 20044480; 20056178; 20070156; 20089160; 20140262; 20237496; 20406964; 20419088; 20429924; 20438785; 20452482; 20453000; 20468071; 20485444; 20503287; 20505188; 20519647; 20540789; 20568250; 20580690; 20628086; 20630874; 20635912; 20673868; 20802378; 21036625; 21042230; 21106938; 21297633; 21343381; 21441140; 21555225; 21670971; 21749879; 21876773; 21915051; 21948388; 21989491; 22076427; 22088968; 22117410; 22152684; 22171941; 22203670; 22231733; 22242662; 22…
description: chemokine (C-X-C motif) receptor 2
database cross reference: Ensembl:ENSG00000180871
database cross reference: HGNC:6027
database cross reference: HPRD:00907
database cross reference: MIM:146928
database cross reference: Vega:OTTHUMG00000133107

IL10
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CSIF
alternative term: GVHDS
alternative term: IL-10
alternative term: IL10A
alternative term: TGIF
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL10
full name from nomenclature authority: interleukin 10
NCBI GeneID: 3586
NCBI LocusTag: RP11-262N9.1
gene map location: 1q31-q32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002237 (EC: IDA, PMID: 17449476); GO_0002740 (EC: IDA, PMID: 10443688); GO_0002875 (EC: IEA); GO_0002904 (EC: IDA, PMID: 9184696); GO_0005125 (EC: NAS, PMID: 10443688); GO_0005141 (EC: NAS, PMID: 1847510); GO_0005615 (EC: IDA, PMID: 10443688); GO_0006954 (EC: IDA, PMID: 10443688); GO_0007253 (EC: NAS, PMID: 10975994); GO_0007267 (EC: IC, PMID: 1847510); GO_0008083 (EC: NAS, PMID: 1371884); GO_0010468 (EC: IDA, PMID: 9184696); GO_0014823 (EC: IEA); GO_0014854 (EC: IEA); GO_0030097 (EC: TAS, PMID: 11244051); GO_0030183 (EC: NAS, PMID: 8228801); GO_0030595 (EC: TAS, PMID: 9405662); GO_0030886 (EC: IEA); GO_0030889 (EC: IDA, PMID: 9184696); GO_0032689 (EC: IEA); GO_0032695 (EC: IEA); GO_0032715 (EC: IDA, PMID: 10443688); GO_0032720 (EC: IEA); GO_0032800 (EC: IDA, PMID: 10443688); GO_0032868 (EC: IEA); GO_0034465 (EC: IEA); GO_0042092 (EC: TAS, PMID: 11244051); GO_0042100 (EC: NAS, PMID: 8228801); GO_0042130 (EC: NAS, PMID: 14971032); GO_0042493 (EC: IEA); GO_0042536 (EC: IEA); GO_0042742 (EC: IEA); GO_0043066 (EC: NAS, PMID: 8312229); GO_0044130 (EC: IEA); GO_0045019 (EC: IEA); GO_0045191 (EC: NAS, PMID: 8228801); GO_0045347 (EC: TAS, PMID: 11244051); GO_0045348 (EC: IEA); GO_0045355 (EC: NAS, PMID: 9637497); GO_0045893 (EC: IDA, PMID: 7749983); GO_0045944 (EC: IEA); GO_0050715 (EC: IDA, PMID: 10443688); GO_0051045 (EC: IDA, PMID: 18383040); GO_0051091 (EC: IDA, PMID: 7749983); GO_0051384 (EC: IDA, PMID: 10443688); GO_0051930 (EC: IEA); GO_0060670 (EC: IEA); GO_0071222 (EC: NAS, PMID: 14971032); GO_0071392 (EC: IEA)
has PubMed association: PMID: 1121048; 1350294; 1371884; 1847510; 2173142; 7511078; 7527834; 7547951; 7553888; 7590988; 7591871; 7695626; 7749063; 7749983; 7759550; 7815507; 8037735; 8228801; 8248239; 8312229; 8364028; 8402911; 8499633; 8590020; 8764000; 8881045; 8897595; 8898665; 8910398; 9043871; 9096366; 9108403; 9143942; 9162098; 9184696; 9225992; 9234486; 9312047; 9334723; 9405662; 9463379; 9534962; 9637497; 9658081; 9689103; 9743208; 9788463; 10064624; 10089566; 10231374; 10443688; 10542212; 10714547; 10775602; 10807185; 10975994; 10985253; 11023480; 11023665; 11044099; 11087201; 11121048; 11137132; 11160847; 11163082; 11168433; 11192323; 11196656; 11196688; 11196718; 11212157; 11223972; 11230752; 11233912; 11238636; 11244051; 11260510; 11266927; 11266928; 11267084; 11271474; 11292301; 11294564; 11298547; 11307152; 11315919; 11316066; 11316069; 11354638; 11391238; 11404167; 11436536; 11441115; 11477472; 11478505; 11485736; 11493351; 11496247; 11517440; 11528523; 11544427; 11544434; 11544437; 11640949; 11689215; 11715070; 11717514; 11737614; 11740730; 11745479; 11758730; 11777537; 11792123; 11805149; 11820460; 11821159; 11828010; 11829538; 11833470; 11838849; 11852287; 11857058; 11869683; 11881827; 11883743; 11896938; 11906646; 11908705; 11919157; 11920312; 11922883; 11928840; 11929132; 11943322; 11952921; 11953141; 11953994; 11956022; 11960393; 11964134; 11964300; 11970958; 11986609; 11991675; 11994432; 12011375; 12020266; 12028020; 12039409; 12042661; 12047360; 12050565; 12060853; 12067976; 12069178; 12069391; 12078789; 12089333; 12089714; 12093676; 12095061; 12095128; 12097418; 12100571; 12100575; 12101075; 12104048; 12115622; 12117955; 12119553; 12121678; 12121679; 12124654; 12133353; 12133517; 12145682; 12151439; 12160736; 12164325; 12164877; 12165551; 12170266; 12189567; 12190181; 12197884; 12202153; 12203138; 12207099; 12207325; 12207353; 12209037; 12215823; 12219016; 12220553; 12220699; 12223518; 12232842; 12233881; 12239181; 12270545; 12370394; 12377950; 12389080; 12390476; 1…
description: interleukin 10
database cross reference: Ensembl:ENSG00000136634
database cross reference: HGNC:5962
database cross reference: HPRD:00495
database cross reference: MIM:124092
database cross reference: Vega:OTTHUMG00000036386

IL11
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AGIF
alternative term: IL-11
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL11
full name from nomenclature authority: interleukin 11
NCBI GeneID: 3589
gene map location: 19q13.3-q13.4
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005125 (EC: IEA); GO_0005142 (EC: NAS, PMID: 2145578); GO_0005576 (EC: IC, PMID: 2145578); GO_0005615 (EC: IEA); GO_0005737 (EC: IEA); GO_0007267 (EC: IC, PMID: 2145578); GO_0008083 (EC: IDA, PMID: 2145578); GO_0008284 (EC: IDA, PMID: 2145578); GO_0030183 (EC: NAS, PMID: 2145578); GO_0030219 (EC: NAS, PMID: 2145578); GO_0033138 (EC: IDA, PMID: 7508917); GO_0043410 (EC: IDA, PMID: 7508917); GO_0045444 (EC: NAS, PMID: 1828438); GO_0045944 (EC: IDA, PMID: 7508917); GO_0046888 (EC: IDA, PMID: 7867561); GO_0050731 (EC: IDA, PMID: 7508917)
has PubMed association: PMID: 1292471; 1386338; 1828438; 2145578; 7499280; 7508917; 7670098; 7867561; 8383296; 8913282; 8940087; 10026196; 10504396; 10725745; 10948192; 11940481; 12005542; 12032273; 12197884; 12477932; 12486609; 12569176; 12584029; 12629504; 12740032; 12760902; 12819039; 14734714; 15004839; 15025215; 15121272; 15307108; 15377473; 15381181; 15389536; 15489334; 15504551; 15543003; 15613426; 15614128; 15784719; 16149067; 16189514; 16614887; 16709613; 16759877; 16964382; 17000646; 17295091; 17325843; 17332920; 17702845; 17703412; 17713553; 18204920; 18433382; 18490653; 18941632; 18987331; 19121317; 19213836; 19223152; 19251839; 19258923; 19548631; 19647472; 19716605; 19801577; 19913506; 20008143; 20360315; 20503287; 20553623; 20640990; 20712807; 21042281; 21138838; 21155043; 21442077; 21443102; 21485496; 21688123; 21741611; 21840908; 21986128; 21995459; 22168497; 22180059; 22205539; 22253262; 22289923; 22393310; 22433466; 22457856; 22523320; 22568077; 22595646; 22614117; 22644863; 22707562; 22727646; 23027619; 23226926; 23307318; 23311882; 23317891; 23340433; 23549086; 23639700; 23813214; 24036113; 24219324; 24297922
description: interleukin 11
database cross reference: Ensembl:ENSG00000095752
database cross reference: HGNC:5966
database cross reference: HPRD:00980
database cross reference: MIM:147681
database cross reference: Vega:OTTHUMG00000180789

IL12A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CLMF
alternative term: IL-12A
alternative term: NFSK
alternative term: NKSF1
alternative term: P35
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL12A
full name from nomenclature authority: interleukin 12A
NCBI GeneID: 3592
gene map location: 3q25.33
modification date: 20140409
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001916 (EC: IDA, PMID: 1674604); GO_0002860 (EC: IDA, PMID: 7903063); GO_0005125 (EC: IDA, Qualifier: contributes_to, PMID: 1674604); GO_0005125 (EC: TAS, Qualifier: contributes_to, PMID: 1673147); GO_0005143 (EC: NAS, PMID: 1674604); GO_0005515 (EC: IPI, PMID: 10899108); GO_0005615 (EC: IDA, PMID: 16456693); GO_0005737 (EC: IEA); GO_0006955 (EC: TAS, PMID: 9789052); GO_0007050 (EC: IDA, PMID: 16942485); GO_0008083 (EC: IDA, Qualifier: contributes_to, PMID: 1674604); GO_0008083 (EC: NAS, Qualifier: contributes_to, PMID: 1673147); GO_0009615 (EC: IEP, PMID: 16548883); GO_0010224 (EC: IDA, PMID: 8992506); GO_0016477 (EC: IDA, PMID: 7903063); GO_0032496 (EC: IDA, PMID: 7605994); GO_0032700 (EC: IDA, PMID: 16482511); GO_0032729 (EC: IDA, PMID: 11114383); GO_0032816 (EC: IDA, PMID: 1674604); GO_0034393 (EC: IDA, PMID: 16942485); GO_0042102 (EC: IEA); GO_0042163 (EC: IEA); GO_0042520 (EC: IDA, PMID: 12372421); GO_0042832 (EC: IEA); GO_0043514 (EC: IDA, PMID: 11114383); GO_0043514 (EC: NAS, PMID: 14718574); GO_0045513 (EC: IPI, PMID: 9342359); GO_0045582 (EC: IEA); GO_0045785 (EC: IDA, PMID: 7903063); GO_0045954 (EC: IDA, PMID: 2204066); GO_0046982 (EC: IPI, PMID: 1674604); GO_0048662 (EC: IDA, PMID: 16942485); GO_0050671 (EC: IDA, PMID: 1674604); GO_0050830 (EC: IEP, PMID: 1357073); GO_0051135 (EC: IDA, PMID: 19088061); GO_0097191 (EC: IDA, PMID: 16942485)
has PubMed association: PMID: 934235; 1350290; 1357073; 1358798; 1673147; 1674604; 2204066; 7516408; 7527811; 7605994; 7695626; 7867080; 7903063; 8557999; 8648753; 8700208; 8760829; 8992506; 9108403; 9158092; 9225992; 9334723; 9342359; 9516412; 9603732; 9616161; 9671213; 9712080; 9789052; 10089131; 10320373; 10352291; 10899108; 11087201; 11114383; 11751963; 11940489; 12117904; 12213961; 12242445; 12270766; 12358856; 12370346; 12372421; 12444143; 12472178; 12477932; 12542496; 12558814; 12576336; 12633940; 12672403; 12719551; 12911539; 12944981; 14566095; 14597672; 14629328; 14660053; 14675394; 14718574; 14764743; 14962816; 15051764; 15087447; 15142381; 15170937; 15331709; 15356557; 15361128; 15448160; 15489234; 15643599; 15741223; 15780175; 15810889; 15817944; 15863393; 15937086; 15956545; 15963597; 16230423; 16456693; 16482511; 16544245; 16548883; 16573560; 16702372; 16754651; 16803996; 16862120; 16885196; 16938461; 16942485; 16961803; 17002904; 17007011; 17062130; 17077296; 17152005; 17225924; 17236132; 17257312; 17304101; 17361014; 17431094; 17444864; 17461482; 17509455; 17553352; 17564777; 17586317; 17627763; 17640324; 17653830; 17671745; 17703412; 17846855; 17881511; 17922692; 17947455; 18050195; 18092318; 18159163; 18190588; 18260379; 18300344; 18311140; 18385764; 18413324; 18417583; 18419254; 18554158; 18566447; 18588867; 18606709; 18628242; 18632425; 18633131; 18671862; 18672993; 18676680; 18717726; 18773331; 18805825; 18972297; 18976327; 19012493; 19013323; 19031096; 19073967; 19074885; 19088061; 19117745; 19118071; 19126646; 19144161; 19148899; 19170196; 19200845; 19230467; 19234184; 19253530; 19258923; 19275586; 19297619; 19299334; 19332120; 19339796; 19376105; 19408823; 19454678; 19458352; 19470040; 19505916; 19508433; 19516896; 19525953; 19543959; 19566870; 19573080; 19594368; 19625176; 19646340; 19692168; 19693089; 19710469; 19773279; 19789190; 19797506; 19798410; 19879194; 19885559; 19913121; 19950173; 19956842; 20012528; 20027291; 20054003; 20060272; 20061784; 20082482; 2019…
description: interleukin 12A
database cross reference: Ensembl:ENSG00000168811
database cross reference: HGNC:5969
database cross reference: HPRD:01193
database cross reference: MIM:161560
database cross reference: Vega:OTTHUMG00000158942

IL16
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LCF
alternative term: NIL16
alternative term: PRIL16
alternative term: prIL-16
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL16
full name from nomenclature authority: interleukin 16
NCBI GeneID: 3603
gene map location: 15q26.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005125 (EC: IEA); GO_0005615 (EC: IEA); GO_0005634 (EC: IDA); GO_0005737 (EC: IDA); GO_0005886 (EC: IDA); GO_0006351 (EC: IEA); GO_0006355 (EC: IEA); GO_0006955 (EC: TAS, PMID: 9144227); GO_0016032 (EC: IEA); GO_0030595 (EC: IEA); GO_0050930 (EC: IEA)
has PubMed association: PMID: 1851800; 6729885; 7615501; 7910967; 8125298; 8599832; 8609984; 8977168; 9144227; 9271307; 9422780; 9699630; 9743378; 9990060; 10343113; 10438516; 10477592; 10479680; 11032842; 11714796; 11937573; 11999883; 12191564; 12450396; 12477932; 12620798; 12923170; 14657881; 14702039; 14705216; 14718574; 14734747; 14755377; 15175077; 15187155; 15253385; 15342983; 15383572; 15560757; 15619436; 15682385; 15784111; 15820794; 15886011; 16144798; 16177102; 16178875; 16189514; 16271292; 16344560; 16375755; 16387589; 16447204; 16455991; 17221335; 17303923; 17537415; 17551575; 17576577; 17577790; 17703412; 18006695; 18029348; 18097041; 18264096; 18394967; 18446062; 18633131; 18676870; 18768901; 18821565; 19060904; 19066394; 19073878; 19074885; 19232499; 19240061; 19258923; 19298795; 19460752; 19476022; 19758567; 19773451; 19789190; 19906316; 19913121; 20079227; 20237496; 20503287; 20529140; 20578037; 20628086; 20662556; 20800603; 20802378; 20811626; 20878214; 21036918; 21071540; 21094786; 21214401; 21267712; 21447961; 21703255; 22019522; 22080865; 22745469; 22923025; 22939228; 23020666; 23241166; 23252864; 23455924; 23881440; 23894370; 24200060
description: interleukin 16
database cross reference: Ensembl:ENSG00000172349
database cross reference: HGNC:5980
database cross reference: HPRD:04329
database cross reference: MIM:603035
database cross reference: Vega:OTTHUMG00000144186

IL18
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IGIF
alternative term: IL-18
alternative term: IL-1g
alternative term: IL1F4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL18
full name from nomenclature authority: interleukin 18
NCBI GeneID: 3606
gene map location: 11q22.2-q22.3
modification date: 20140409
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: IMP); GO_0001525 (EC: IDA, PMID: 11466388); GO_0005125 (EC: TAS, PMID: 11598150); GO_0005576 (EC: TAS, PMID: 11598150); GO_0005615 (EC: IEA); GO_0005829 (EC: TAS); GO_0006954 (EC: IDA); GO_0006955 (EC: TAS, PMID: 8999896); GO_0007267 (EC: TAS, PMID: 9792649); GO_0010628 (EC: IEA); GO_0030101 (EC: IEA); GO_0030155 (EC: IDA, PMID: 11477102); GO_0030431 (EC: ISS, PMID: 11506998); GO_0031663 (EC: IDA); GO_0032725 (EC: IDA); GO_0032729 (EC: IDA, PMID: 19088061); GO_0032740 (EC: IDA, PMID: 16482511); GO_0032819 (EC: IDA, PMID: 19088061); GO_0034105 (EC: IC, PMID: 16482511); GO_0042033 (EC: TAS, PMID: 11598150); GO_0042088 (EC: IDA, PMID: 8766574); GO_0042092 (EC: TAS, PMID: 11905033); GO_0042094 (EC: TAS, PMID: 10653850); GO_0042095 (EC: TAS, PMID: 10227975); GO_0042104 (EC: IDA, PMID: 10000000); GO_0042231 (EC: TAS, PMID: 10227975); GO_0042253 (EC: TAS, PMID: 10653850); GO_0042346 (EC: IEA); GO_0050729 (EC: IC, PMID: 16482511); GO_0051142 (EC: IDA, PMID: 19088061); GO_0071407 (EC: IDA)
has PubMed association: PMID: 7477296; 8666798; 8766574; 8999548; 8999896; 9108085; 9325300; 9334240; 9693051; 9792649; 10000000; 10227975; 10460493; 10639148; 10653850; 10681439; 11466388; 11477102; 11506998; 11598150; 11714750; 11714826; 11770036; 11781190; 11790772; 11798931; 11805151; 11855785; 11888846; 11894141; 11895335; 11905033; 11907126; 11920321; 11936774; 11958300; 11960649; 12096920; 12105209; 12149432; 12172382; 12207348; 12366781; 12377944; 12381835; 12387830; 12390326; 12401730; 12424620; 12438388; 12456593; 12472176; 12472673; 12477932; 12482935; 12517977; 12527894; 12571842; 12572878; 12594843; 12616343; 12654091; 12679613; 12738632; 12748489; 12759422; 12788305; 12794718; 12796418; 12819633; 12847274; 12857602; 12858406; 12874316; 12911784; 12938205; 12941729; 12947340; 14504095; 14556808; 14561165; 14581397; 14584052; 14605444; 14617033; 14630085; 14640907; 14660053; 14662834; 14679107; 14697936; 14709415; 14718574; 14725568; 14734463; 14738910; 14764217; 14960579; 14991611; 14998974; 15005726; 15104599; 15140035; 15212675; 15225625; 15230817; 15277983; 15302292; 15308504; 15326478; 15327523; 15358638; 15371332; 15463896; 15471361; 15489334; 15555533; 15581980; 15585330; 15643599; 15644127; 15645140; 15646011; 15663745; 15674367; 15710458; 15728489; 15731584; 15753257; 15760905; 15786533; 15789055; 15802534; 15806006; 15816833; 15826815; 15842270; 15860738; 15860756; 15863395; 15894108; 15896202; 15927856; 15932380; 15955098; 15963597; 16024007; 16043644; 16049975; 16051062; 16052331; 16053025; 16059673; 16061751; 16078996; 16084898; 16186395; 16215941; 16243298; 16260350; 16266857; 16273766; 16306550; 16306764; 16306765; 16315783; 16316892; 16325763; 16339124; 16358956; 16373926; 16405895; 16406079; 16406656; 16420594; 16424284; 16428475; 16433722; 16433859; 16443795; 16482511; 16492204; 16493047; 16514436; 16516851; 16556702; 16563174; 16571086; 16584830; 16621994; 16635219; 16647017; 16650813; 16671950; 16738942; 16759385; 16767839; 16772281; 16780720; 16806233; 1682…
description: interleukin 18
database cross reference: Ensembl:ENSG00000150782
database cross reference: HGNC:5986
database cross reference: HPRD:02976
database cross reference: MIM:600953
database cross reference: Vega:OTTHUMG00000167006

INS
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IDDM1
alternative term: IDDM2
alternative term: ILPR
alternative term: IRDN
alternative term: MODY10
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: INS
full name from nomenclature authority: insulin
NCBI GeneID: 3630
gene map location: 11p15.5
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: IDA, PMID: 11278339); GO_0002020 (EC: IPI); GO_0002674 (EC: IDA, PMID: 11443198); GO_0005158 (EC: IDA, PMID: 7556975); GO_0005158 (EC: IPI, PMID: 8452530); GO_0005159 (EC: IPI, PMID: 8452530); GO_0005179 (EC: IC, PMID: 9667398); GO_0005179 (EC: IMP, PMID: 381941); GO_0005179 (EC: NAS, PMID: 14986111); GO_0005515 (EC: IPI, PMID: 9388210); GO_0005576 (EC: IC, PMID: 7556975); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 9667398); GO_0005788 (EC: TAS); GO_0005796 (EC: TAS); GO_0006006 (EC: IEA); GO_0006112 (EC: TAS); GO_0006355 (EC: NAS, PMID: 12881524); GO_0006521 (EC: IMP, PMID: 3553851); GO_0006953 (EC: IDA, PMID: 14739855); GO_0007186 (EC: IDA, PMID: 9092559); GO_0007267 (EC: IC, PMID: 7556975); GO_0008284 (EC: IDA, PMID: 17925406); GO_0008286 (EC: TAS); GO_0014068 (EC: IDA, PMID: 7688386); GO_0015758 (EC: IDA, PMID: 14615391); GO_0022898 (EC: IDA, PMID: 14615391); GO_0030307 (EC: NAS, PMID: 11742412); GO_0030335 (EC: ISS, PMID: 12138094); GO_0031018 (EC: TAS); GO_0031904 (EC: TAS); GO_0031954 (EC: ISS, PMID: 3518947); GO_0032148 (EC: IDA, PMID: 8702995); GO_0032270 (EC: IMP, PMID: 3553851); GO_0032460 (EC: IDA, PMID: 9830016); GO_0032880 (EC: IDA, PMID: 14615391); GO_0033861 (EC: IDA, PMID: 11443198); GO_0034774 (EC: TAS); GO_0042060 (EC: IDA, PMID: 9498508); GO_0042177 (EC: IDA, PMID: 15185208); GO_0042593 (EC: IMP, PMID: 381941); GO_0042802 (EC: IPI); GO_0043410 (EC: IDA, PMID: 11500939); GO_0044267 (EC: TAS); GO_0044281 (EC: TAS); GO_0045429 (EC: NAS, PMID: 14615391); GO_0045597 (EC: NAS, PMID: 11742412); GO_0045721 (EC: NAS, PMID: 11742412); GO_0045725 (EC: IDA, PMID: 17925406); GO_0045740 (EC: IDA, PMID: 7688386); GO_0045818 (EC: IMP, PMID: 381941); GO_0045821 (EC: IDA, PMID: 7688386); GO_0045821 (EC: IMP, PMID: 381941); GO_0045840 (EC: IDA, PMID: 10644978); GO_0045861 (EC: IMP, PMID: 3553851); GO_0045908 (EC: NAS, PMID: 12946932); GO_0045909 (EC: NAS, PMID: 14744991); GO_0045922 (EC: IMP, PMID: 1184755); GO_0046326 (EC: IDA, PMID: 14615391…
has PubMed association: PMID: 195962; 381941; 503234; 1184755; 1406615; 1433291; 1601997; 1646635; 1851182; 1959628; 2036420; 2196279; 2271664; 2550426; 3470784; 3511099; 3518947; 3537011; 3553851; 4019786; 4443293; 4698553; 4698555; 4803504; 5101771; 5560404; 6243748; 6248962; 6253909; 6312455; 6351842; 6382002; 6424111; 6927840; 7027261; 7350438; 7477119; 7556975; 7688386; 7716547; 7773291; 7818556; 8358440; 8421693; 8452530; 8496180; 8524413; 8702995; 8971927; 9092559; 9141561; 9235985; 9388210; 9498508; 9631292; 9667398; 9773776; 9830016; 10084601; 10383393; 10497219; 10604997; 10644978; 10909971; 10938588; 10966857; 10969839; 11101842; 11140838; 11145591; 11278339; 11347740; 11376336; 11387233; 11398136; 11443198; 11500939; 11502799; 11511079; 11606170; 11738155; 11739440; 11742412; 11779231; 11779865; 11800057; 11866509; 11912547; 11937112; 11953210; 11978629; 12021212; 12029093; 12032154; 12047362; 12051853; 12072386; 12079889; 12086926; 12101177; 12111440; 12133430; 12135947; 12138094; 12182905; 12186542; 12189018; 12364457; 12378388; 12392301; 12404181; 12441313; 12477932; 12479880; 12529491; 12589110; 12610512; 12620428; 12624089; 12631734; 12637980; 12639765; 12654724; 12660731; 12709672; 12715715; 12721156; 12750767; 12803245; 12821730; 12881524; 12930990; 12946932; 12952878; 13658959; 14426955; 14551916; 14607844; 14615391; 14616883; 14633852; 14647005; 14651526; 14657411; 14659752; 14671163; 14671189; 14671204; 14679083; 14693412; 14707040; 14715866; 14739855; 14744991; 14749349; 14979729; 14986111; 15028719; 15046555; 15047631; 15070567; 15095040; 15111508; 15126243; 15161800; 15163889; 15170498; 15185208; 15194403; 15220197; 15220214; 15230641; 15237706; 15240646; 15265780; 15277396; 15305767; 15342556; 15351621; 15367890; 15473891; 15489334; 15529622; 15538935; 15561961; 15581831; 15583859; 15589123; 15591776; 15610006; 15613433; 15616007; 15632182; 15678496; 15684637; 15699505; 15705595; 15705917; 15792832; 15834700; 15880482; 15889096; 15919610; 15920061; 15922332; 15928…
description: insulin
database cross reference: Ensembl:ENSG00000254647
database cross reference: HGNC:6081
database cross reference: HPRD:01455
database cross reference: MIM:176730
database cross reference: Vega:OTTHUMG00000009558

INPP5D
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SHIP
alternative term: SHIP-1
alternative term: SHIP1
alternative term: SIP-145
alternative term: hp51CN
alternative term: p150Ship
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: INPP5D
full name from nomenclature authority: inositol polyphosphate-5-phosphatase, 145kDa
NCBI GeneID: 3635
gene map location: 2q37.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004445 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10382761); GO_0005829 (EC: TAS); GO_0006644 (EC: TAS); GO_0006661 (EC: TAS); GO_0006796 (EC: TAS, PMID: 8769125); GO_0006915 (EC: IEA); GO_0007165 (EC: TAS, PMID: 8769125); GO_0007596 (EC: TAS); GO_0008340 (EC: IEA); GO_0009968 (EC: IEA); GO_0016020 (EC: IEA); GO_0016064 (EC: IEA); GO_0017124 (EC: IEA); GO_0030889 (EC: IEA); GO_0034594 (EC: IEA); GO_0035556 (EC: IEA); GO_0043065 (EC: IEA); GO_0043647 (EC: TAS); GO_0044281 (EC: TAS); GO_0045409 (EC: IEA); GO_0045579 (EC: IEA); GO_0045648 (EC: IEA); GO_0045656 (EC: IEA); GO_0045659 (EC: IEA); GO_0045671 (EC: IEA); GO_0045779 (EC: IEA); GO_0046856 (EC: IEA); GO_0050777 (EC: IEA); GO_0050852 (EC: TAS); GO_0050900 (EC: TAS); GO_0051425 (EC: IEA)
has PubMed association: PMID: 8643691; 8654924; 8723348; 8769125; 8874179; 9058707; 9108392; 9110989; 9148918; 9341117; 9422771; 9531585; 9918857; 10194451; 10229804; 10350061; 10382761; 10660611; 10704825; 10733577; 10748054; 10822173; 10875931; 10900203; 11071635; 11157475; 11247302; 11287610; 11402314; 11443118; 11692111; 11714803; 11724799; 12024011; 12029088; 12217402; 12393695; 12421919; 12477932; 12829595; 12882960; 14688341; 14702039; 14993273; 15090612; 15166241; 15184070; 15470047; 15492005; 15604218; 15644415; 15735664; 15944314; 15953601; 16038794; 16406061; 16428799; 16619039; 16682172; 16818760; 17342744; 17371259; 17657219; 19041431; 19380743; 19473701; 19641183; 19682241; 19839650; 19880507; 19890474; 19913121; 19954644; 20041145; 20304029; 20331378; 20379614; 20628086; 20697350; 20972266; 21155837; 21275903; 21378990; 21402888; 21622861; 21695085; 21864674; 21906983; 22249254; 22267732; 22412388; 22575191; 22706086; 22815893; 22820502; 23128233; 23154388; 23998585; 24095650; 24302498; 24391219; 24522920
description: inositol polyphosphate-5-phosphatase, 145kDa
database cross reference: Ensembl:ENSG00000168918
database cross reference: HGNC:6079
database cross reference: HPRD:09033
database cross reference: MIM:601582

INSR
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD220
alternative term: HHF5
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: INSR
full name from nomenclature authority: insulin receptor
NCBI GeneID: 3643
gene map location: 19p13.3-p13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: IMP, PMID: 17001305); GO_0001934 (EC: IDA, PMID: 7556070); GO_0003007 (EC: IMP, PMID: 7693131); GO_0004713 (EC: IDA, PMID: 8496180); GO_0004713 (EC: IMP, PMID: 7537849); GO_0004716 (EC: IDA, PMID: 6849137); GO_0005009 (EC: IDA, PMID: 6849137); GO_0005159 (EC: IDA, PMID: 8452530); GO_0005515 (EC: IPI, PMID: 10500481); GO_0005524 (EC: IDA, PMID: 6849137); GO_0005525 (EC: IDA, PMID: 9092559); GO_0005886 (EC: IC, PMID: 6849137); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 9092559); GO_0005899 (EC: IMP, PMID: 15069075); GO_0005901 (EC: IDA, PMID: 15182363); GO_0005975 (EC: IEA); GO_0006355 (EC: IMP, PMID: 12881524); GO_0007186 (EC: IDA, PMID: 9092559); GO_0008284 (EC: IC, PMID: 11500939); GO_0008284 (EC: IDA, PMID: 17925406); GO_0008286 (EC: IDA, PMID: 6849137); GO_0008286 (EC: TAS); GO_0010008 (EC: TAS); GO_0016020 (EC: IDA, PMID: 8452530); GO_0018108 (EC: IDA, PMID: 8496180); GO_0019087 (EC: IMP, PMID: 17001305); GO_0023014 (EC: IDA, PMID: 6849137); GO_0030238 (EC: IEA); GO_0030335 (EC: IMP, PMID: 12138094); GO_0031017 (EC: IEA); GO_0031994 (EC: IPI, PMID: 8452530); GO_0031995 (EC: IPI, PMID: 12138094); GO_0032147 (EC: IMP, PMID: 9819385); GO_0032148 (EC: IDA, PMID: 7556070); GO_0032869 (EC: IDA, PMID: 8440175); GO_0042169 (EC: IPI, PMID: 8276809); GO_0042593 (EC: IMP, PMID: 7693131); GO_0043235 (EC: IDA); GO_0043410 (EC: IMP, PMID: 11500939); GO_0043548 (EC: IPI, PMID: 7537849); GO_0043559 (EC: IDA, PMID: 8440175); GO_0043559 (EC: IPI, PMID: 8452530); GO_0043560 (EC: IPI, PMID: 7493946); GO_0045429 (EC: IMP, PMID: 10747347); GO_0045725 (EC: IDA, PMID: 17925406); GO_0045740 (EC: IMP, PMID: 12138094); GO_0045821 (EC: IMP, PMID: 7693131); GO_0045840 (EC: IMP, PMID: 11500939); GO_0045995 (EC: IMP, PMID: 7693131); GO_0046326 (EC: IDA, PMID: 3518947); GO_0046326 (EC: NAS, PMID: 11001060); GO_0046777 (EC: IDA, PMID: 6849137); GO_0046777 (EC: IMP, PMID: 7537849); GO_0048639 (EC: IMP, PMID: 7693131); GO_0051290 (EC: IDA, PMID: 1898103); GO_0051425 (EC: IPI…
has PubMed association: PMID: 185872; 1304913; 1314826; 1315125; 1321126; 1321605; 1324934; 1331107; 1373652; 1472036; 1563582; 1607067; 1607076; 1644241; 1648089; 1657953; 1730625; 1890161; 1898103; 1956339; 1963473; 1971035; 1986371; 1993068; 2002058; 2040394; 2121734; 2168397; 2210055; 2211730; 2280779; 2365819; 2369896; 2460770; 2479553; 2538124; 2544997; 2544998; 2550426; 2566545; 2573522; 2777789; 2806055; 2834824; 2842060; 2859121; 2983222; 2986535; 3101064; 3109943; 3166375; 3283938; 3447155; 3518947; 3546306; 3680248; 6849137; 7028018; 7479769; 7493946; 7512963; 7529876; 7535775; 7537849; 7538143; 7556070; 7559478; 7592607; 7613486; 7626603; 7657032; 7693131; 7794689; 7806540; 7815442; 7836419; 7860063; 7895674; 7906861; 7926007; 7929343; 7935368; 7953556; 7983039; 7997262; 8027066; 8082780; 8096518; 8101305; 8114715; 8135823; 8188715; 8242067; 8243830; 8276809; 8288049; 8314008; 8326490; 8347587; 8385099; 8388389; 8390949; 8419945; 8432414; 8440175; 8452530; 8454633; 8458533; 8463287; 8463311; 8496180; 8504096; 8513978; 8557631; 8603569; 8621530; 8626379; 8636294; 8639568; 8662806; 8692915; 8702728; 8826975; 8890729; 8900242; 8912646; 8916919; 9006901; 9083103; 9092546; 9092559; 9121430; 9122188; 9175790; 9195949; 9197239; 9199575; 9249867; 9299395; 9312016; 9355745; 9398630; 9428692; 9446569; 9449692; 9492017; 9506989; 9507031; 9524259; 9658397; 9703342; 9710204; 9722981; 9741627; 9742218; 9748281; 9756945; 9819385; 9819414; 10026153; 10084586; 10196204; 10340378; 10437794; 10443650; 10453981; 10482988; 10500481; 10594240; 10598578; 10615944; 10635327; 10650943; 10733238; 10747347; 10764799; 10803466; 10805733; 10816433; 10830280; 10871840; 10896916; 10921922; 10978177; 11001060; 11071852; 11075717; 11094073; 11158333; 11208515; 11232039; 11260230; 11266508; 11279102; 11289049; 11342531; 11374898; 11401470; 11409918; 11500939; 11506178; 11551902; 11604231; 11606564; 11694516; 11726652; 11735220; 11781100; 11866509; 11875066; 11994298; 11997497; 12023989; 12031977; 12031982; 1210…
description: insulin receptor
database cross reference: Ensembl:ENSG00000171105
database cross reference: HGNC:6091
database cross reference: HPRD:00975
database cross reference: MIM:147670
database cross reference: Vega:OTTHUMG00000181992

IREB2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ACO3
alternative term: IRP2
alternative term: IRP2AD
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IREB2
full name from nomenclature authority: iron-responsive element binding protein 2
NCBI GeneID: 3658
gene map location: 15q25.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003723 (EC: IDA, PMID: 7983023); GO_0003723 (EC: TAS, PMID: 9924025); GO_0005515 (EC: IPI, PMID: 19762596); GO_0005737 (EC: NAS, PMID: 7983023); GO_0005739 (EC: IEA); GO_0005829 (EC: IEA); GO_0006417 (EC: IEA); GO_0006782 (EC: IEA); GO_0006826 (EC: TAS, PMID: 9924025); GO_0006879 (EC: IEA); GO_0007568 (EC: IEA); GO_0009791 (EC: IEA); GO_0010040 (EC: IEA); GO_0030316 (EC: IEA); GO_0030350 (EC: TAS, PMID: 9924025); GO_0032526 (EC: IEA); GO_0034101 (EC: IEA); GO_0046872 (EC: IEA); GO_0050892 (EC: IEA); GO_0051539 (EC: IEA); GO_0071456 (EC: IEA)
has PubMed association: PMID: 1421965; 2172968; 7489724; 7523370; 7622457; 7983023; 9560204; 9924025; 11783942; 12192037; 12200453; 12465072; 12477932; 12629548; 12855587; 12888568; 14673166; 15057521; 15146197; 15777842; 15938636; 16503547; 16914832; 17200797; 17604281; 17613866; 17760563; 17822790; 18574241; 18582596; 19223469; 19762596; 19762597; 19800047; 20173748; 20405006; 20587604; 20587610; 20656943; 20877624; 21139048; 21320324; 21558272; 21832049; 21890473; 21906983; 21963094; 21987572; 21988832; 22079093; 22080838; 22093897; 22331484; 22356581; 22461431; 22505724; 22863883; 22914670; 23000965; 23251661; 23741361; 24285726
description: iron-responsive element binding protein 2
database cross reference: Ensembl:ENSG00000136381
database cross reference: HGNC:6115
database cross reference: HPRD:08858
database cross reference: MIM:147582
database cross reference: Vega:OTTHUMG00000143861

IRS1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HIRS-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IRS1
full name from nomenclature authority: insulin receptor substrate 1
NCBI GeneID: 3667
gene map location: 2q36
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002053 (EC: IEA); GO_0004871 (EC: IEA); GO_0005068 (EC: ISS); GO_0005080 (EC: ISS); GO_0005158 (EC: IPI, PMID: 7493946); GO_0005159 (EC: IPI, PMID: 7541045); GO_0005515 (EC: IPI, PMID: 11018022); GO_0005634 (EC: ISS); GO_0005737 (EC: ISS); GO_0005829 (EC: TAS); GO_0005886 (EC: TAS); GO_0005899 (EC: ISS); GO_0005901 (EC: IDA, PMID: 15182363); GO_0007165 (EC: TAS, PMID: 1311924); GO_0007173 (EC: TAS); GO_0008284 (EC: NAS, PMID: 17925406); GO_0008286 (EC: IDA, PMID: 16516141); GO_0008286 (EC: IMP, PMID: 16814735); GO_0008286 (EC: IPI, PMID: 7537849); GO_0008286 (EC: TAS); GO_0008543 (EC: TAS); GO_0010468 (EC: IEA); GO_0010907 (EC: IMP, PMID: 16814735); GO_0014065 (EC: IDA, PMID: 7782332); GO_0016042 (EC: IEA); GO_0030335 (EC: IEA); GO_0030879 (EC: IEA); GO_0032000 (EC: IMP, PMID: 16814735); GO_0032868 (EC: IDA, PMID: 16516141); GO_0032869 (EC: IMP, PMID: 16814735); GO_0034504 (EC: IEA); GO_0038095 (EC: TAS); GO_0042169 (EC: ISS); GO_0042593 (EC: TAS, PMID: 16814735); GO_0043231 (EC: ISS); GO_0043434 (EC: ISS); GO_0043491 (EC: IEA); GO_0043548 (EC: IPI, PMID: 16043515); GO_0043548 (EC: ISS); GO_0043552 (EC: ISS); GO_0045087 (EC: TAS); GO_0045725 (EC: IMP, PMID: 16814735); GO_0045725 (EC: NAS, PMID: 17925406); GO_0046326 (EC: IMP, PMID: 16814735); GO_0046627 (EC: ISS); GO_0046628 (EC: ISS); GO_0046676 (EC: IDA, PMID: 15572028); GO_0048009 (EC: IPI, PMID: 7541045); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0060397 (EC: TAS); GO_2001275 (EC: IDA, PMID: 7493946)
has PubMed association: PMID: 1311924; 1381348; 1648180; 7488107; 7493946; 7499194; 7499365; 7537849; 7541045; 7542745; 7559478; 7559507; 7782332; 7935368; 7935386; 8020946; 8104271; 8175658; 8240352; 8349691; 8388384; 8491186; 8505282; 8513971; 8524391; 8530377; 8536716; 8550573; 8557683; 8599766; 8621530; 8621590; 8626379; 8626671; 8631859; 8633037; 8662806; 8723689; 8732688; 8776723; 8810325; 9111084; 9174053; 9202037; 9295312; 9312143; 9415396; 9422753; 9492017; 9748281; 9756938; 9792713; 9822703; 9837978; 9843575; 10026153; 10082579; 10206679; 10411883; 10417350; 10455176; 10497255; 10660596; 10669726; 10679027; 10722755; 10843189; 10854852; 10856136; 11006284; 11018022; 11035789; 11063744; 11120660; 11147812; 11162588; 11172806; 11208867; 11287026; 11287630; 11289056; 11317670; 11522686; 11579209; 11604231; 11606564; 11694888; 11739394; 11775217; 11781100; 11872698; 11874945; 11877394; 11912194; 11969417; 11978177; 12006586; 12031982; 12107745; 12107746; 12167717; 12173038; 12213887; 12220227; 12228220; 12351658; 12354757; 12358865; 12370850; 12409308; 12414625; 12417588; 12475767; 12477526; 12477932; 12493740; 12510059; 12524443; 12554758; 12560071; 12565902; 12588284; 12606535; 12624099; 12660731; 12679424; 12730242; 12732844; 12763374; 12765939; 12783867; 12819898; 12821935; 12843189; 12910680; 12933652; 12934392; 12960006; 14511371; 14559999; 14583092; 14602724; 14604996; 14633864; 14642408; 14668342; 14671192; 14693412; 14707024; 14966273; 14968112; 14988278; 15001544; 15003536; 15044323; 15069075; 15127203; 15155816; 15161794; 15182363; 15209769; 15222685; 15240653; 15247132; 15308584; 15316008; 15318176; 15324660; 15364919; 15474880; 15489334; 15514089; 15516986; 15522123; 15561965; 15561966; 15572028; 15581831; 15582274; 15588985; 15590636; 15592455; 15604215; 15629149; 15634339; 15636429; 15665022; 15678496; 15705377; 15759454; 15778465; 15781195; 15802620; 15849359; 15926113; 15940190; 15965906; 15985484; 16020478; 16030120; 16037106; 16043515; 16084882; 16127460; 16128672;…
description: insulin receptor substrate 1
database cross reference: Ensembl:ENSG00000169047
database cross reference: HGNC:6125
database cross reference: HPRD:00943
database cross reference: MIM:147545
database cross reference: Vega:OTTHUMG00000133179

JAK2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: JTK10
alternative term: THCYT3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: JAK2
full name from nomenclature authority: Janus kinase 2
NCBI GeneID: 3717
gene map location: 9p24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000186 (EC: IEA); GO_0004672 (EC: NAS, PMID: 9670957); GO_0004713 (EC: EXP); GO_0004713 (EC: ISS); GO_0004713 (EC: TAS); GO_0004715 (EC: IEA); GO_0005102 (EC: IPI, PMID: 11201744); GO_0005131 (EC: ISS); GO_0005143 (EC: ISS); GO_0005515 (EC: IPI, PMID: 11679576); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA, PMID: 10502458); GO_0005737 (EC: IDA, PMID: 10502458); GO_0005829 (EC: TAS); GO_0005856 (EC: IEA); GO_0005901 (EC: ISS); GO_0006468 (EC: TAS, PMID: 9670957); GO_0006915 (EC: ISS); GO_0006919 (EC: ISS); GO_0006928 (EC: TAS, PMID: 9670957); GO_0007165 (EC: ISS); GO_0007167 (EC: ISS); GO_0007186 (EC: IEA); GO_0007204 (EC: IEA); GO_0007259 (EC: TAS, PMID: 9670957); GO_0007260 (EC: ISS); GO_0007262 (EC: ISS); GO_0007498 (EC: TAS, PMID: 9590174); GO_0007596 (EC: TAS); GO_0008022 (EC: IEA); GO_0008284 (EC: IEA); GO_0008285 (EC: ISS); GO_0008631 (EC: IEA); GO_0009755 (EC: IEA); GO_0010811 (EC: IDA, PMID: 10925297); GO_0014068 (EC: ISS); GO_0016363 (EC: IEA); GO_0018108 (EC: ISS); GO_0019221 (EC: IDA, PMID: 8609418); GO_0019221 (EC: ISS); GO_0019221 (EC: TAS); GO_0019901 (EC: IDA, PMID: 10925297); GO_0020037 (EC: IDA); GO_0022408 (EC: IEA); GO_0030041 (EC: NAS, PMID: 10925297); GO_0030154 (EC: ISS); GO_0030218 (EC: ISS); GO_0030335 (EC: IEA); GO_0031103 (EC: IEA); GO_0031702 (EC: IEA); GO_0031904 (EC: TAS); GO_0031959 (EC: IEA); GO_0032024 (EC: IEA); GO_0032496 (EC: ISS); GO_0032516 (EC: IEA); GO_0032731 (EC: IEA); GO_0032760 (EC: ISS); GO_0033130 (EC: IEA); GO_0033160 (EC: IEA); GO_0033194 (EC: IEA); GO_0033209 (EC: IDA, PMID: 8609418); GO_0034050 (EC: IEA); GO_0034612 (EC: IDA, PMID: 8609418); GO_0035401 (EC: IDA, PMID: 19783980); GO_0035409 (EC: IDA, PMID: 19783980); GO_0035556 (EC: ISS); GO_0035722 (EC: IDA, PMID: 7528775); GO_0042169 (EC: IPI, PMID: 9727029); GO_0042393 (EC: IDA, PMID: 19783980); GO_0042503 (EC: IEA); GO_0042506 (EC: IEA); GO_0042508 (EC: IEA); GO_0042517 (EC: ISS); GO_0042523 (EC: ISS); GO_0042977 (EC: ISS); GO_0043065 (EC: IEA); GO_0043388 (EC: IE…
has PubMed association: PMID: 1581631; 1848670; 7499845; 7500025; 7514165; 7527392; 7528775; 7530656; 7534285; 7535773; 7540178; 7543024; 7559603; 7657660; 7673114; 7690989; 7746328; 7775438; 7812050; 7889566; 7925280; 8041779; 8063815; 8343951; 8493579; 8536716; 8608603; 8609418; 8611693; 8617237; 8626374; 8631301; 8631962; 8639815; 8657151; 8702385; 8756581; 8876196; 8912646; 8943354; 8950973; 8995399; 9012831; 9038232; 9047382; 9111318; 9126968; 9133424; 9162069; 9169451; 9178903; 9202126; 9202403; 9211920; 9326218; 9343427; 9344848; 9355737; 9363897; 9388212; 9446644; 9452495; 9473212; 9484840; 9492017; 9510175; 9516124; 9553131; 9553136; 9573010; 9575217; 9590174; 9618263; 9632636; 9670957; 9689060; 9727029; 9837922; 10026141; 10064597; 10198225; 10205168; 10224114; 10358079; 10374881; 10421843; 10455112; 10455176; 10477722; 10502458; 10506573; 10531356; 10551884; 10586060; 10635327; 10692450; 10747872; 10757801; 10772872; 10809230; 10842184; 10842319; 10872802; 10872831; 10882725; 10899310; 10918061; 10918587; 10925297; 10938266; 10954736; 10979953; 11087817; 11152457; 11163768; 11201744; 11208867; 11278610; 11278738; 11294897; 11313464; 11314018; 11350938; 11373296; 11413148; 11430697; 11438544; 11440634; 11493922; 11585385; 11591716; 11593427; 11679576; 11694501; 11698276; 11713228; 11731619; 11779507; 11818507; 11839738; 11875116; 11923474; 11934902; 11940567; 11940572; 11971965; 12007403; 12023369; 12023981; 12106016; 12207328; 12223098; 12244095; 12351625; 12370296; 12370803; 12441334; 12456798; 12456871; 12477932; 12478664; 12538627; 12540842; 12551917; 12552091; 12576423; 12626508; 12637327; 12668872; 12777975; 12817007; 12960006; 14500680; 14522994; 14551204; 14551213; 14565954; 14968112; 14978237; 14982882; 15121872; 15143187; 15143188; 15156153; 15164053; 15198092; 15284024; 15322115; 15358195; 15475610; 15514089; 15604419; 15611059; 15615703; 15666812; 15676212; 15677497; 15688010; 15767667; 15781101; 15793561; 15805263; 15821101; 15837627; 15858187; 15860661; 15863514; 15…
description: Janus kinase 2
database cross reference: Ensembl:ENSG00000096968
database cross reference: HGNC:6192
database cross reference: HPRD:00993
database cross reference: MIM:147796
database cross reference: Vega:OTTHUMG00000019490

JUN
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AP-1
alternative term: AP1
alternative term: c-Jun
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: JUN
full name from nomenclature authority: jun proto-oncogene
NCBI GeneID: 3725
gene map location: 1p32-p31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000228 (EC: TAS, PMID: 10918580); GO_0000980 (EC: IDA, PMID: 19861239); GO_0001077 (EC: IEA); GO_0001102 (EC: IPI, PMID: 19861239); GO_0001190 (EC: IC, PMID: 19861239); GO_0001525 (EC: IEA); GO_0001774 (EC: IEA); GO_0001836 (EC: IEA); GO_0001889 (EC: IEA); GO_0001938 (EC: IEA); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0003151 (EC: IEA); GO_0003677 (EC: TAS, PMID: 2825349); GO_0003690 (EC: IEA); GO_0003700 (EC: IDA, PMID: 9732876); GO_0003705 (EC: IC, PMID: 19861239); GO_0003705 (EC: IDA, PMID: 2833704); GO_0003713 (EC: IDA, PMID: 2833704); GO_0005100 (EC: IDA, PMID: 11804590); GO_0005515 (EC: IPI, PMID: 10327051); GO_0005654 (EC: TAS); GO_0005667 (EC: IEA); GO_0005719 (EC: IDA, PMID: 19861239); GO_0005829 (EC: IEA); GO_0007179 (EC: IDA, PMID: 9732876); GO_0007184 (EC: IDA, PMID: 9732876); GO_0007568 (EC: IEA); GO_0007612 (EC: IEA); GO_0007623 (EC: IEA); GO_0008134 (EC: IPI, PMID: 16007074); GO_0008285 (EC: IEA); GO_0009314 (EC: IEA); GO_0009612 (EC: IEA); GO_0017053 (EC: IEA); GO_0030224 (EC: IEA); GO_0031103 (EC: IEA); GO_0031953 (EC: IEA); GO_0032321 (EC: IDA, PMID: 11804590); GO_0032496 (EC: IEA); GO_0034097 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035026 (EC: IEA); GO_0035497 (EC: IDA, PMID: 19861239); GO_0035666 (EC: TAS); GO_0038095 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042493 (EC: IEA); GO_0042542 (EC: IEA); GO_0043392 (EC: IDA, PMID: 14645924); GO_0043524 (EC: IEA); GO_0043525 (EC: IEA); GO_0043922 (EC: IDA, PMID: 2833704); GO_0043923 (EC: IDA, PMID: 2833704); GO_0044212 (EC: IDA, PMID: 14645924); GO_0044822 (EC: IDA); GO_0045087 (EC: TAS); GO_0045657 (EC: IEA); GO_0045740 (EC: IEA); GO_0045892 (EC: IDA, PMID: 2833704); GO_0045893 (EC: IDA, PMID: 2833704); GO_0045944 (EC: IC, PMID: 19861239); GO_0045944 (EC: IDA, PMID: 2833704); GO_0048146 (EC: IEA); GO_0048661 (EC: IEA); GO_0051090 (EC: TAS); GO_00513…
has PubMed association: PMID: 1310896; 1448082; 1516134; 1631061; 1651323; 1827203; 1922387; 2138276; 2320002; 2825349; 2833704; 3194415; 7623830; 7642615; 7662174; 7666555; 7690421; 7738014; 7816143; 7823959; 7848298; 7957556; 8001819; 8027667; 8087846; 8108109; 8137421; 8224842; 8302594; 8380166; 8387155; 8397339; 8440710; 8464713; 8480425; 8557686; 8570175; 8586671; 8617242; 8621542; 8621941; 8622660; 8628277; 8649793; 8654373; 8662824; 8663380; 8663478; 8733011; 8763994; 8798722; 8816797; 8816798; 8837781; 8846788; 8945519; 8974016; 8985011; 9020136; 9030721; 9129988; 9154808; 9155018; 9160889; 9207092; 9211894; 9223324; 9235954; 9334186; 9346889; 9374537; 9405416; 9443941; 9445037; 9468519; 9488446; 9510247; 9545246; 9566900; 9575168; 9621077; 9628874; 9642216; 9659924; 9670954; 9671405; 9681824; 9685505; 9692890; 9732876; 9774977; 9786917; 9808624; 9837938; 9872330; 9973222; 10026157; 10027715; 10188588; 10196196; 10207054; 10220381; 10327051; 10330159; 10346818; 10357819; 10388555; 10393177; 10419510; 10421840; 10428834; 10478848; 10488148; 10490605; 10490649; 10497212; 10506225; 10509564; 10523647; 10567391; 10567404; 10581001; 10620019; 10637231; 10644332; 10747973; 10766246; 10777532; 10788439; 10799874; 10847592; 10878360; 10903323; 10903862; 10913197; 10918580; 10962563; 10973489; 11022789; 11053448; 11090181; 11108663; 11254713; 11260070; 11274169; 11278277; 11278395; 11278640; 11278891; 11287617; 11306568; 11316804; 11331419; 11331585; 11371641; 11397794; 11431474; 11432833; 11448159; 11477071; 11479302; 11551904; 11641401; 11689449; 11704680; 11708771; 11738026; 11739718; 11801649; 11804590; 11823437; 11867732; 11877416; 11891228; 11891317; 11903046; 11909859; 11912197; 11914583; 11948398; 11956220; 11980644; 11983170; 12034730; 12052834; 12052862; 12077347; 12080089; 12087103; 12089333; 12091339; 12119282; 12145210; 12165517; 12167088; 12183893; 12185592; 12186939; 12228228; 12324474; 12419228; 12419805; 12437352; 12441106; 12446585; 12477932; 12485413; 12547826; 12554755; …
description: jun proto-oncogene
database cross reference: Ensembl:ENSG00000177606
database cross reference: HGNC:6204
database cross reference: HPRD:01302
database cross reference: MIM:165160
database cross reference: Vega:OTTHUMG00000008376

KPNA1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IPOA5
alternative term: NPI-1
alternative term: RCH2
alternative term: SRP1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: KPNA1
full name from nomenclature authority: karyopherin alpha 1 (importin alpha 5)
NCBI GeneID: 3836
gene map location: 3q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000018 (EC: TAS, PMID: 8052633); GO_0005515 (EC: IPI, PMID: 12011095); GO_0005634 (EC: IDA); GO_0005634 (EC: ISS); GO_0005643 (EC: TAS, PMID: 8052633); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0006309 (EC: TAS); GO_0006607 (EC: TAS, PMID: 7754385); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0008139 (EC: TAS, PMID: 7754385); GO_0008565 (EC: IEA); GO_0016032 (EC: TAS); GO_0019058 (EC: TAS); GO_0019221 (EC: TAS); GO_0030425 (EC: ISS); GO_0042307 (EC: ISS); GO_0075733 (EC: TAS)
has PubMed association: PMID: 1631159; 1985200; 2064827; 7494303; 7559393; 7585960; 7604027; 7745752; 7754385; 7831767; 7859280; 7892216; 8041734; 8041786; 8052633; 8105392; 8529100; 8551560; 8552640; 8619474; 8631802; 8659115; 8692858; 8707840; 8777717; 8876228; 9008157; 9020149; 9102465; 9110174; 9261351; 9275210; 9282826; 9303297; 9366553; 9436978; 9463369; 9548947; 9557700; 9562972; 9582382; 9593140; 9603322; 9695948; 9817747; 9918876; 10366569; 10473610; 10523667; 10525473; 10748034; 10772949; 10860744; 10888652; 10888660; 10951564; 10964507; 11032817; 11035935; 11060446; 11152524; 11278458; 11389849; 11682607; 11824786; 11904219; 11927559; 12011095; 12048190; 12368302; 12414950; 12477932; 12504543; 12610148; 12740372; 12783858; 12861017; 14600264; 14702039; 15037073; 15057270; 15142377; 15231748; 15342649; 15489334; 15731250; 15942031; 16135813; 16298512; 16344560; 16439554; 16698996; 16713569; 17304248; 17344301; 17353931; 17411366; 17643375; 17928350; 17938174; 17981117; 18238777; 18707546; 19001869; 19066626; 19118899; 19270695; 19338763; 19412186; 19596235; 19615732; 19801544; 19803398; 19889762; 19961612; 20015032; 20193720; 20360068; 20406804; 20705733; 20974480; 21139048; 21145461; 21209321; 21252943; 21307607; 21318276; 21326825; 21385873; 21890473; 21906983; 21963094; 21987768; 21988832; 22110766; 22130666; 22174317; 22321063; 22399302; 22422068; 22500989; 22509482; 22770219; 22778253; 22863883; 22939629; 22990118; 23000965; 23425335; 23602568; 23752268; 24163370; 24250222; 24269683
description: karyopherin alpha 1 (importin alpha 5)
database cross reference: Ensembl:ENSG00000114030
database cross reference: HGNC:6394
database cross reference: HPRD:02819
database cross reference: MIM:600686
database cross reference: Vega:OTTHUMG00000159487

KPNB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IMB1
alternative term: IPO1
alternative term: IPOB
alternative term: Impnb
alternative term: NTF97
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: KPNB1
full name from nomenclature authority: karyopherin (importin) beta 1
NCBI GeneID: 3837
gene map location: 17q21.32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000060 (EC: TAS, PMID: 7615630); GO_0005515 (EC: IPI, PMID: 11311162); GO_0005634 (EC: IDA); GO_0005635 (EC: IDA); GO_0005643 (EC: TAS, PMID: 7627554); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0006309 (EC: TAS); GO_0006606 (EC: IDA, PMID: 15964792); GO_0006607 (EC: TAS, PMID: 7627554); GO_0006610 (EC: IDA, PMID: 9687515); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0008139 (EC: TAS, PMID: 7627554); GO_0008270 (EC: TAS, PMID: 7615630); GO_0008536 (EC: IEA); GO_0008565 (EC: IEA); GO_0016032 (EC: TAS); GO_0019058 (EC: TAS); GO_0019221 (EC: TAS); GO_0019899 (EC: IPI); GO_0019904 (EC: IPI, PMID: 11984006); GO_0031965 (EC: IDA); GO_0044281 (EC: TAS); GO_0044822 (EC: IDA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0071782 (EC: IDA); GO_0075733 (EC: TAS)
has PubMed association: PMID: 1631159; 1985200; 7559393; 7615630; 7627554; 8105392; 8576188; 8617226; 8617227; 8692944; 8896452; 8909533; 9045717; 9102465; 9135132; 9144189; 9214382; 9261175; 9275187; 9275210; 9323134; 9366553; 9398662; 9405152; 9430704; 9435235; 9436978; 9463369; 9562972; 9582382; 9621063; 9670026; 9687515; 9817747; 9891055; 9891056; 10037787; 10202161; 10209022; 10228156; 10353244; 10366569; 10367892; 10397761; 10473610; 10523667; 10525473; 10668806; 10749866; 10772949; 10779340; 10811646; 10822175; 10846168; 10860744; 10888652; 10929717; 10944119; 10951564; 10965137; 11024021; 11032817; 11035935; 11257130; 11266456; 11278458; 11283257; 11297531; 11310559; 11311162; 11323423; 11389849; 11401507; 11751052; 11971900; 11984006; 12011095; 12062430; 12095920; 12135354; 12176322; 12368302; 12414950; 12477932; 12504010; 12551970; 12614157; 12764225; 12783858; 12894213; 13679510; 14600264; 14718574; 15037768; 15047060; 15194443; 15231748; 15282309; 15297880; 15342649; 15383276; 15388255; 15489334; 15494309; 15572412; 15795315; 15851029; 15864302; 15870280; 15889150; 15964792; 16115628; 16196087; 16226712; 16314522; 16344560; 16354571; 16380377; 16552725; 16704975; 16982803; 17053781; 17110338; 17148452; 17172643; 17314511; 17370265; 17537211; 17573780; 17596301; 17609381; 17620599; 17643375; 17646395; 17661632; 17855385; 17916694; 17938174; 18028944; 18029348; 18051367; 18162579; 18238777; 18258596; 18398821; 18445273; 18655775; 18854154; 19056867; 19117056; 19149558; 19156129; 19275582; 19322201; 19454010; 19596686; 19738201; 19765186; 19801544; 19884259; 19925438; 20015032; 20085707; 20360068; 20462248; 20547757; 20603015; 20639865; 20658144; 20711181; 20811636; 21081666; 21139048; 21145461; 21209321; 21278340; 21319273; 21321119; 21326825; 21401918; 21625522; 21630149; 21832065; 21890473; 21900206; 21906983; 21963094; 21965294; 21987572; 22020938; 22053931; 22125623; 22145905; 22174317; 22178446; 22190364; 22222486; 22268729; 22321063; 22355797; 22415091; 22417684; 22422068; …
description: karyopherin (importin) beta 1
database cross reference: HGNC:6400
database cross reference: HPRD:04114
database cross reference: MIM:602738

KPNA5
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IPOA6
alternative term: SRP6
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: KPNA5
full name from nomenclature authority: karyopherin alpha 5 (importin alpha 6)
NCBI GeneID: 3841
NCBI LocusTag: RP3-412I7.4
gene map location: 6q22.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 15057270); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0006607 (EC: TAS, PMID: 9395085); GO_0008565 (EC: IEA); GO_0019221 (EC: TAS)
has PubMed association: PMID: 1631159; 2064827; 7494303; 7566098; 7585960; 7745752; 7859280; 8041734; 8041786; 8105392; 8529100; 8551560; 8552640; 8659115; 8876228; 9008157; 9275210; 9282826; 9303297; 9366553; 9395085; 9463369; 9548947; 9557700; 9562972; 9593140; 9603322; 9918876; 10366569; 10525473; 10860744; 10888652; 10964507; 11035935; 11278458; 11389849; 11904219; 12368302; 12414950; 12477932; 12610148; 12740372; 15037073; 15057270; 16713569; 16919237; 17207965; 17411366; 17643375; 17981117; 19961612; 20015032; 20406804; 21145461; 21326825; 21460395; 21890473; 21906983; 22509482; 22939629
description: karyopherin alpha 5 (importin alpha 6)
database cross reference: Ensembl:ENSG00000196911
database cross reference: HGNC:6398
database cross reference: HPRD:05179
database cross reference: MIM:604545

LAG3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD223
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LAG3
full name from nomenclature authority: lymphocyte-activation gene 3
NCBI GeneID: 3902
gene map location: 12p13.32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003823 (EC: TAS, PMID: 1692078); GO_0004888 (EC: IEA); GO_0007166 (EC: IEA); GO_0009897 (EC: IEA); GO_0016021 (EC: IEA); GO_0042289 (EC: IDA, PMID: 9159144); GO_0045085 (EC: IEA); GO_0045954 (EC: IEA); GO_0050868 (EC: IEA)
has PubMed association: PMID: 1380059; 1692078; 8097522; 9159144; 9382927; 9634475; 9780176; 10545478; 11592063; 11937541; 12477932; 12775570; 12825348; 14644131; 15674389; 16519819; 16757686; 17020785; 18322184; 19773279; 20228263; 20237496; 20331378; 20385810; 20421648; 20568250; 21441454; 23261718
description: lymphocyte-activation gene 3
database cross reference: Ensembl:ENSG00000089692
database cross reference: HGNC:6476
database cross reference: HPRD:01077
database cross reference: MIM:153337
database cross reference: Vega:OTTHUMG00000169197

LCK
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LSK
alternative term: YT16
alternative term: p56lck
alternative term: pp58lck
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LCK
full name from nomenclature authority: lymphocyte-specific protein tyrosine kinase
NCBI GeneID: 3932
NCBI LocusTag: RP4-675E8.4
gene map location: 1p34.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000242 (EC: IDA, PMID: 7513706); GO_0000242 (EC: ISS); GO_0001772 (EC: IDA); GO_0001948 (EC: IPI, PMID: 14625311); GO_0003823 (EC: IEA); GO_0004713 (EC: EXP); GO_0004713 (EC: IDA, PMID: 214242); GO_0004713 (EC: ISS); GO_0004713 (EC: TAS); GO_0004715 (EC: IEA); GO_0004722 (EC: IDA, PMID: 8506364); GO_0004722 (EC: ISS); GO_0005515 (EC: IPI, PMID: 10209036); GO_0005524 (EC: IEA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 12150984); GO_0005886 (EC: TAS); GO_0006468 (EC: IDA, PMID: 214242); GO_0006882 (EC: IEP, PMID: 11739864); GO_0006882 (EC: ISS); GO_0006919 (EC: IDA, PMID: 16116473); GO_0006919 (EC: ISS); GO_0007173 (EC: TAS); GO_0007568 (EC: IEA); GO_0007596 (EC: TAS); GO_0008022 (EC: IPI, PMID: 16245368); GO_0008543 (EC: TAS); GO_0009612 (EC: IEA); GO_0010043 (EC: IEA); GO_0010628 (EC: IEA); GO_0016032 (EC: TAS); GO_0016311 (EC: IDA, PMID: 8506364); GO_0016311 (EC: ISS); GO_0019901 (EC: IPI, PMID: 8618896); GO_0019903 (EC: IPI); GO_0030097 (EC: NAS, PMID: 12884910); GO_0030139 (EC: IEA); GO_0030168 (EC: TAS); GO_0030217 (EC: IMP, PMID: 1579166); GO_0030217 (EC: ISS); GO_0031295 (EC: TAS); GO_0032403 (EC: IEA); GO_0038095 (EC: TAS); GO_0042169 (EC: IPI, PMID: 7852312); GO_0042169 (EC: ISS); GO_0042493 (EC: IDA, PMID: 16116473); GO_0042493 (EC: ISS); GO_0042523 (EC: IEA); GO_0042542 (EC: IEA); GO_0042609 (EC: IPI, PMID: 7486703); GO_0042610 (EC: IPI, PMID: 2470098); GO_0042802 (EC: IPI, PMID: 17118402); GO_0043548 (EC: IPI, PMID: 7504174); GO_0045087 (EC: TAS); GO_0045121 (EC: IDA, PMID: 12150984); GO_0045121 (EC: ISS); GO_0045588 (EC: IEA); GO_0046777 (EC: IEA); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0050690 (EC: TAS); GO_0050852 (EC: TAS); GO_0050853 (EC: IEA); GO_0050862 (EC: NAS, PMID: 12614355); GO_0050870 (EC: IDA, PMID: 8943371); GO_0050870 (EC: ISS); GO_0050900 (EC: TAS); GO_0051117 (EC: IPI, PMID: 15671290); GO_0051209 (EC: ISS); GO_0051249 (EC: NAS, PMID: 7852312); GO_0070062 (EC: IDA); GO_0070474 (EC: IEA); GO_2001244 (EC: IMP, PMID: 1611…
has PubMed association: PMID: 214242; 1351058; 1382070; 1385527; 1491632; 1500851; 1535086; 1535787; 1548763; 1579166; 1622897; 1638019; 1709155; 1850098; 1988541; 2014052; 2040625; 2047859; 2115123; 2470098; 2558056; 2787474; 2835736; 2850479; 3257410; 3265417; 3489486; 3493153; 7486703; 7494315; 7495859; 7504174; 7512963; 7513045; 7513706; 7522245; 7539035; 7539106; 7539724; 7543024; 7545683; 7657660; 7680610; 7682059; 7690989; 7774645; 7831289; 7852312; 7853525; 7859737; 7871751; 7896837; 7961936; 8020561; 8062594; 8077654; 8086341; 8104794; 8114715; 8139546; 8246987; 8258691; 8262984; 8294442; 8405050; 8473339; 8506364; 8551220; 8576115; 8576267; 8618896; 8626429; 8626543; 8626561; 8636141; 8648738; 8650207; 8663450; 8671590; 8692915; 8702662; 8794306; 8797825; 8798643; 8798764; 8864141; 8870842; 8871625; 8879209; 8883579; 8887682; 8900205; 8910285; 8939988; 8943371; 8945479; 8995379; 9020138; 9032261; 9036944; 9038134; 9043947; 9045636; 9047237; 9075929; 9091579; 9092949; 9121430; 9123823; 9169414; 9178760; 9178909; 9195899; 9257837; 9269777; 9312162; 9341123; 9341793; 9344703; 9403695; 9446569; 9461588; 9488700; 9573028; 9621091; 9624175; 9664084; 9685404; 9687533; 9705913; 9710204; 9712716; 9741627; 9751747; 9778343; 9788619; 9790917; 9792645; 9880255; 9973379; 9973453; 9989602; 10208934; 10209036; 10214954; 10229084; 10318843; 10330160; 10358157; 10364375; 10383400; 10422873; 10430626; 10447714; 10449731; 10455176; 10482988; 10488096; 10544125; 10553045; 10574931; 10617656; 10636863; 10642173; 10652356; 10669745; 10733577; 10748115; 10764799; 10790433; 10799545; 10799874; 10799879; 10816433; 10825200; 10858437; 10880360; 10896916; 10918587; 10921922; 10975838; 11048639; 11067948; 11075717; 11278465; 11278738; 11294838; 11294897; 11298344; 11351273; 11369760; 11381116; 11389730; 11431473; 11525746; 11572860; 11591716; 11739864; 11741599; 11741929; 11741956; 11827988; 11839738; 11854499; 11855827; 11904433; 12007789; 12036857; 12055221; 12100025; 12150984; 12171035; 12181444; 1218656…
description: lymphocyte-specific protein tyrosine kinase
database cross reference: Ensembl:ENSG00000182866
database cross reference: HGNC:6524
database cross reference: HPRD:01080
database cross reference: MIM:153390
database cross reference: Vega:OTTHUMG00000007463

LDLR
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FH
alternative term: FHC
alternative term: LDLCQ2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LDLR
full name from nomenclature authority: low density lipoprotein receptor
NCBI GeneID: 3949
gene map location: 19p13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001523 (EC: TAS); GO_0001948 (EC: IPI, PMID: 10571240); GO_0005041 (EC: IDA, PMID: 6091915); GO_0005509 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12221107); GO_0005764 (EC: IDA, PMID: 15166224); GO_0005769 (EC: IDA, PMID: 15166224); GO_0005770 (EC: IDA, PMID: 17461796); GO_0005794 (EC: IDA, PMID: 17461796); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 6327078); GO_0005905 (EC: IDA, PMID: 15166224); GO_0006629 (EC: TAS, PMID: 10827173); GO_0006897 (EC: TAS, PMID: 12671190); GO_0006898 (EC: TAS); GO_0007603 (EC: TAS); GO_0008203 (EC: IEA); GO_0009897 (EC: IDA, PMID: 15166224); GO_0009986 (EC: IDA, PMID: 17461796); GO_0010008 (EC: TAS); GO_0010867 (EC: ISS); GO_0010899 (EC: ISS); GO_0015914 (EC: ISS); GO_0016032 (EC: IEA); GO_0030169 (EC: IEA); GO_0030229 (EC: IDA, PMID: 8626535); GO_0030299 (EC: IMP, PMID: 17142622); GO_0030301 (EC: IMP, PMID: 17142622); GO_0030669 (EC: TAS); GO_0034362 (EC: IEA); GO_0034383 (EC: IMP, PMID: 17142622); GO_0042157 (EC: TAS); GO_0042159 (EC: IEA); GO_0042632 (EC: IMP, PMID: 17142622); GO_0043235 (EC: IDA); GO_0044281 (EC: TAS); GO_0070508 (EC: ISS)
has PubMed association: PMID: 221835; 226968; 1301956; 1446662; 1464748; 1609792; 1634609; 1734722; 1757095; 1833771; 1867200; 1978682; 1999337; 2318961; 2352257; 2544509; 2569482; 2570157; 2726768; 2760198; 2760205; 2777800; 2805380; 2831865; 2837085; 2855802; 2901412; 2920733; 2988123; 3005267; 3012527; 3020025; 3104336; 3198114; 3263645; 3343347; 3549308; 3627182; 3815525; 3866240; 3924410; 3955657; 6091915; 6129958; 6291781; 6299582; 6326146; 6327078; 7550239; 7573037; 7578052; 7581403; 7583548; 7603991; 7635461; 7635482; 7649546; 7649549; 7718019; 7822276; 8096412; 8141835; 8168830; 8182149; 8300609; 8347689; 8462973; 8555255; 8626535; 8664907; 8740918; 8889549; 9016531; 9026534; 9104431; 9143924; 9222758; 9254862; 9259195; 9262405; 9265653; 9555943; 9654205; 9678702; 9733438; 9744476; 9788750; 9837937; 9852677; 10090484; 10206683; 10330445; 10380922; 10391209; 10422803; 10447263; 10571240; 10660340; 10827173; 10832106; 10882754; 10884290; 10906332; 10933493; 11050659; 11100124; 11149418; 11157985; 11173876; 11194026; 11247302; 11257257; 11298688; 11317192; 11317361; 11332639; 11453971; 11462246; 11524740; 11668627; 11668640; 11702052; 11737238; 11848618; 11849659; 11851376; 11857755; 11860839; 11916007; 11923121; 11923123; 11933210; 11947895; 11986215; 11997513; 12002911; 12009418; 12031600; 12036962; 12042130; 12048680; 12052488; 12055704; 12072496; 12082592; 12113284; 12121347; 12149270; 12165956; 12169628; 12189808; 12209363; 12221107; 12235180; 12414836; 12417285; 12442279; 12459547; 12464675; 12473254; 12473547; 12477932; 12485531; 12492446; 12493918; 12522687; 12544508; 12551936; 12562867; 12615904; 12671190; 12705331; 12716819; 12730724; 12746448; 12754519; 12810610; 12820708; 12873747; 12898587; 12901493; 12944120; 12947119; 12969990; 12975003; 14508510; 14550622; 14557872; 14568562; 14615367; 14616764; 14624402; 14739284; 14746139; 14756670; 14967814; 14993243; 15015036; 15068387; 15100232; 15133863; 15135251; 15144588; 15166224; 15172466; 15241806; 15286151; 15321837; 15321…
description: low density lipoprotein receptor
database cross reference: Ensembl:ENSG00000130164
database cross reference: HGNC:6547
database cross reference: HPRD:06091
database cross reference: MIM:606945
database cross reference: Vega:OTTHUMG00000171935

LGALS1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GAL1
alternative term: GBP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LGALS1
full name from nomenclature authority: lectin, galactoside-binding, soluble, 1
NCBI GeneID: 3956
gene map location: 22q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001948 (EC: IEA); GO_0002317 (EC: IEA); GO_0004871 (EC: IMP, PMID: 12761501); GO_0005515 (EC: IPI, PMID: 10369126); GO_0005578 (EC: IEA); GO_0005615 (EC: IDA); GO_0005622 (EC: IDA); GO_0005634 (EC: IEA); GO_0005737 (EC: TAS, PMID: 16130169); GO_0006915 (EC: IEA); GO_0007165 (EC: IMP, PMID: 12761501); GO_0009986 (EC: IEA); GO_0010812 (EC: IEA); GO_0010977 (EC: IEA); GO_0016936 (EC: IEA); GO_0030395 (EC: IEA); GO_0031012 (EC: IDA, Qualifier: colocalizes_with); GO_0031012 (EC: ISS, Qualifier: colocalizes_with); GO_0031295 (EC: IEA); GO_0033555 (EC: IEA); GO_0034120 (EC: IEA); GO_0042493 (EC: IEA); GO_0042803 (EC: IEA); GO_0042981 (EC: TAS, PMID: 16130169); GO_0043123 (EC: IMP, PMID: 12761501); GO_0043236 (EC: IEA); GO_0044822 (EC: IDA); GO_0045445 (EC: IEA); GO_0048678 (EC: IEA); GO_0071333 (EC: IEA); GO_0071407 (EC: IEA)
has PubMed association: PMID: 1602151; 1713454; 1988031; 1996404; 2383549; 2719646; 2719964; 2910856; 3020551; 3065332; 3611046; 7501023; 7750127; 7795414; 7821789; 7869048; 8063692; 8432540; 8449510; 8872948; 9264263; 9572443; 9683529; 10369126; 10425546; 10490978; 10591208; 10642604; 10764829; 10950114; 11076863; 11146440; 11256614; 11522829; 11709720; 11846886; 11850528; 11937561; 12008046; 12125737; 12271131; 12477932; 12527107; 12615972; 12665801; 12761501; 12810474; 12823983; 12853445; 14507657; 14550305; 14612929; 14617626; 14693917; 14769876; 15050916; 15297883; 15461802; 15489334; 15489336; 15556936; 15556941; 15663199; 15690107; 15778371; 15862866; 15910247; 15929990; 15972675; 16033063; 16051185; 16130169; 16247730; 16381901; 16388708; 16530434; 16636291; 16751364; 16785517; 16818733; 16940423; 17043243; 17110462; 17177840; 17182582; 17269744; 17304502; 17353931; 17390012; 17438085; 17523619; 17535296; 17537433; 17603562; 17616672; 17649808; 17880528; 17884770; 17984174; 18007053; 18028978; 18223683; 18258591; 18292532; 18315601; 18431251; 18519761; 18570123; 18581052; 18624398; 18630998; 18633135; 18662664; 18671640; 18691335; 18791848; 18796645; 18802059; 18824694; 18838383; 18947333; 18991278; 19011096; 19032754; 19064001; 19103599; 19116313; 19125585; 19128029; 19148478; 19155496; 19171142; 19225046; 19287070; 19287997; 19363525; 19412433; 19454697; 19471022; 19492862; 19506091; 19520156; 19550395; 19561030; 19635795; 19688976; 19730683; 19738201; 19860718; 19886821; 19898636; 19900702; 19913121; 20006954; 20053628; 20157731; 20177845; 20200618; 20332322; 20360068; 20363255; 20399482; 20525878; 20549082; 20570633; 20592339; 20596638; 20628086; 20644118; 20657665; 20728947; 20816214; 20828557; 20873803; 21113146; 21122983; 21139048; 21147166; 21150319; 21191065; 21292557; 21372130; 21378323; 21385934; 21391228; 21397408; 21505194; 21514365; 21614093; 21632118; 21689853; 21724180; 21747316; 21779348; 21780106; 21807362; 21880716; 21880749; 21890473; 21897333; 21906983; 2196309…
description: lectin, galactoside-binding, soluble, 1
database cross reference: Ensembl:ENSG00000100097
database cross reference: HGNC:6561
database cross reference: HPRD:01040
database cross reference: MIM:150570
database cross reference: Vega:OTTHUMG00000150661

LIPC
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HDLCQ12
alternative term: HL
alternative term: HTGL
alternative term: LIPH
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LIPC
full name from nomenclature authority: lipase, hepatic
NCBI GeneID: 3990
gene map location: 15q21-q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004620 (EC: TAS, PMID: 3244012); GO_0004806 (EC: IDA, PMID: 182536); GO_0005615 (EC: IDA, PMID: 2839510); GO_0006633 (EC: IDA, PMID: 182536); GO_0008201 (EC: IEA); GO_0008203 (EC: IEA); GO_0019433 (EC: IDA, PMID: 182536); GO_0030169 (EC: ISS); GO_0034185 (EC: ISS); GO_0034364 (EC: IEA); GO_0034372 (EC: IDA, PMID: 8640403); GO_0034373 (EC: TAS, PMID: 2839510); GO_0034374 (EC: IMP, PMID: 3244012); GO_0034375 (EC: IMP, PMID: 3244012); GO_0034382 (EC: TAS, PMID: 9685400); GO_0034638 (EC: TAS, PMID: 2839510); GO_0042632 (EC: IMP, PMID: 1883393); GO_0043691 (EC: IC, PMID: 14531818); GO_0070328 (EC: IMP, PMID: 1883393)
has PubMed association: PMID: 182536; 1301939; 1671786; 1883393; 2324091; 2447084; 2605236; 2828141; 2839510; 3244012; 3692485; 7721852; 8640403; 8865179; 8865180; 9645503; 9685400; 10391209; 10660332; 11171287; 11181756; 11322655; 11427182; 11427226; 11454011; 11512679; 11533368; 11752456; 11916946; 11947893; 11968086; 11971936; 12006918; 12082592; 12116231; 12235167; 12354428; 12364471; 12364543; 12403660; 12417924; 12477932; 12514935; 12544508; 12547874; 12642787; 12689525; 12691171; 12700335; 12777470; 12777476; 12798568; 12818414; 12860265; 12883629; 12964943; 12966036; 14531818; 14557872; 14564687; 14585761; 14608050; 14615390; 14630921; 14650352; 14657196; 14679168; 14709367; 14967812; 14985399; 15099346; 15126514; 15135251; 15135253; 15156410; 15205216; 15292235; 15292318; 15304509; 15379569; 15608561; 15656877; 15657615; 15721010; 15755868; 15817871; 15821100; 15855254; 15941898; 15949705; 15961789; 15979432; 15983229; 15983323; 16005462; 16030523; 16038892; 16039291; 16077949; 16115483; 16122151; 16141008; 16153627; 16164573; 16205020; 16316842; 16324926; 16330034; 16338252; 16343038; 16419358; 16427731; 16449872; 16542392; 16554020; 16570154; 16603721; 16770077; 16793047; 16822236; 16879193; 16928730; 17080261; 17137217; 17157861; 17175070; 17222414; 17234195; 17318300; 17327141; 17342071; 17390085; 17399967; 17406067; 17428321; 17440012; 17537154; 17568951; 17700364; 17855807; 17919884; 18001531; 18059528; 18084291; 18160998; 18164013; 18193043; 18193044; 18249219; 18275964; 18354102; 18364377; 18413186; 18468200; 18510853; 18513389; 18592285; 18599739; 18622260; 18636124; 18641720; 18660489; 18675312; 18676680; 18724972; 18758746; 18927546; 18978678; 18996102; 19034316; 19043545; 19052449; 19056482; 19060906; 19060910; 19060911; 19088157; 19101670; 19131662; 19136429; 19148283; 19155102; 19155782; 19170196; 19263529; 19285487; 19336370; 19350521; 19367320; 19420105; 19428034; 19429860; 19479237; 19489872; 19528346; 19534808; 19558527; 19578796; 19625176; 19656773; 19689828; 19…
description: lipase, hepatic
database cross reference: Ensembl:ENSG00000166035
database cross reference: HGNC:6619
database cross reference: HPRD:01058
database cross reference: MIM:151670
database cross reference: Vega:OTTHUMG00000132632

LOX
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LOX
full name from nomenclature authority: lysyl oxidase
NCBI GeneID: 4015
gene map location: 5q23.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001568 (EC: IEA); GO_0004720 (EC: IEA); GO_0005507 (EC: IEA); GO_0005515 (EC: IPI, PMID: 19570982); GO_0005576 (EC: TAS); GO_0005581 (EC: IEA); GO_0005615 (EC: IEA); GO_0005634 (EC: IEA); GO_0006464 (EC: TAS, PMID: 1685472); GO_0030198 (EC: TAS); GO_0030199 (EC: IEA); GO_0030324 (EC: IEA); GO_0042060 (EC: IEA); GO_0042493 (EC: IEA); GO_0048251 (EC: IEA); GO_0048545 (EC: IEA)
has PubMed association: PMID: 1352776; 1357535; 1683640; 1685472; 2863189; 2874833; 3120785; 6127904; 6144680; 6147899; 6912069; 7706256; 7902322; 8082810; 8100215; 8442432; 8636146; 9111998; 10391127; 11642359; 11675877; 11807790; 11916256; 12101112; 12452073; 12477932; 12577300; 12686141; 12750963; 12820424; 15110773; 15137057; 15146197; 15273433; 15374948; 15489334; 15609325; 15843371; 16023247; 16251195; 16344560; 16357151; 16440329; 16533769; 16642001; 17395448; 17616686; 17673218; 17849172; 18566459; 18764858; 19020742; 19029090; 19087518; 19111879; 19394199; 19406911; 19526206; 19570982; 19583806; 19654310; 19661442; 19667273; 19724858; 19816945; 20026874; 20146053; 20179655; 20379614; 20453000; 20498644; 20689807; 20717923; 20812961; 20929399; 20956321; 21215756; 21239473; 21282564; 21306648; 21318022; 21532881; 21536655; 21546528; 21565611; 21575462; 21612403; 21740577; 21995629; 22438909; 22533780; 22722997; 22767499; 22824984; 22883193; 22948781; 22966818; 22994786; 23165370; 23188504; 23262025; 23267843; 23357697; 23400010; 23413043; 23413430; 23494965; 23530115; 23545606; 23560895; 23619422; 23667531; 23886186; 24113189; 24167568
description: lysyl oxidase

LPL
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HDLCQ11
alternative term: LIPD
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LPL
full name from nomenclature authority: lipoprotein lipase
NCBI GeneID: 4023
gene map location: 8p22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001523 (EC: TAS); GO_0004465 (EC: IDA, PMID: 3973011); GO_0004465 (EC: ISS, PMID: 10727238); GO_0004620 (EC: ISS, PMID: 10727238); GO_0004806 (EC: IDA, PMID: 12573449); GO_0004806 (EC: ISS, PMID: 10727238); GO_0005102 (EC: IPI, PMID: 10085125); GO_0005515 (EC: IPI); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 12573449); GO_0005886 (EC: IEA); GO_0006633 (EC: IC, PMID: 3973011); GO_0006633 (EC: IDA, PMID: 182536); GO_0006633 (EC: ISS); GO_0006641 (EC: ISS, PMID: 10727238); GO_0006644 (EC: ISS, PMID: 10727238); GO_0007603 (EC: TAS); GO_0008201 (EC: IDA, PMID: 12573449); GO_0009409 (EC: IEA); GO_0009986 (EC: IEA); GO_0010744 (EC: IC, PMID: 12573449); GO_0010886 (EC: IMP, PMID: 12573449); GO_0010890 (EC: IMP, PMID: 12573449); GO_0017129 (EC: IEA); GO_0019432 (EC: IEA); GO_0019433 (EC: IDA, PMID: 182536); GO_0019433 (EC: ISS); GO_0031012 (EC: IEA); GO_0031225 (EC: IEA); GO_0034185 (EC: IPI, PMID: 15178420); GO_0034361 (EC: IEA); GO_0034371 (EC: IC, PMID: 3973011); GO_0034372 (EC: IDA, PMID: 3973011); GO_0034372 (EC: ISS); GO_0042157 (EC: TAS); GO_0042493 (EC: IEA); GO_0042627 (EC: IEA); GO_0044281 (EC: TAS); GO_0070328 (EC: IGI, PMID: 17018885)
has PubMed association: PMID: 182536; 1281473; 1371284; 1400331; 1406652; 1479292; 1511985; 1521525; 1537564; 1576758; 1598907; 1619366; 1639392; 1674945; 1702428; 1730727; 1731801; 1737848; 1752947; 1907278; 1969408; 1975597; 2010533; 2038366; 2110364; 2121025; 2243796; 2294743; 2340307; 2349938; 2536938; 2701938; 3355847; 3515966; 3692485; 3823907; 3973011; 7510694; 7592875; 7647785; 7686151; 7713910; 7753827; 7806969; 7818530; 7906986; 7989348; 8096693; 8125298; 8135797; 8144523; 8288243; 8301230; 8308035; 8325986; 8449037; 8486765; 8567671; 8956048; 9183545; 9298816; 9374130; 9401010; 9430364; 9519338; 9662394; 9719626; 10085125; 10391209; 10660334; 10727238; 11073182; 11096142; 11126401; 11132601; 11140837; 11171287; 11194013; 11205691; 11229437; 11284423; 11316129; 11341749; 11395037; 11427211; 11441189; 11484171; 11500192; 11533368; 11534394; 11579204; 11593500; 11605530; 11680797; 11683775; 11702052; 11702219; 11711487; 11714857; 11714860; 11730816; 11796707; 11796709; 11834518; 11852057; 11893776; 11893778; 11897170; 11899831; 11921083; 11947965; 11996946; 12042669; 12044583; 12082592; 12107736; 12117735; 12133533; 12133567; 12164879; 12174215; 12208477; 12226739; 12230584; 12370850; 12408999; 12446192; 12477932; 12483461; 12501246; 12514935; 12544508; 12573449; 12636935; 12647273; 12655575; 12679477; 12687649; 12690214; 12701046; 12704407; 12708905; 12732844; 12740382; 12746411; 12747600; 12755701; 12777470; 12782148; 12793009; 12818414; 12862202; 12865761; 12866915; 12876415; 12889841; 12905705; 12915220; 12919138; 12964943; 12966036; 14553962; 14564687; 14570890; 14580156; 14580165; 14581156; 14660566; 14669227; 14693718; 14702039; 14764824; 14967813; 14984315; 14988233; 14988305; 15019539; 15051515; 15060087; 15076187; 15115692; 15127290; 15135251; 15155715; 15178420; 15189363; 15202783; 15221136; 15253101; 15256516; 15257172; 15270617; 15292370; 15292372; 15331147; 15356086; 15386377; 15489334; 15543643; 15545743; 15562208; 15608561; 15637076; 15657615; 15696473; 15699916; 15…
description: lipoprotein lipase
database cross reference: Ensembl:ENSG00000175445
database cross reference: HGNC:6677
database cross reference: HPRD:01999
database cross reference: MIM:609708
database cross reference: Vega:OTTHUMG00000036645

LRP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: A2MR
alternative term: APOER
alternative term: APR
alternative term: CD91
alternative term: IGFBP3R
alternative term: LRP
alternative term: LRP1A
alternative term: TGFBR5
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LRP1
full name from nomenclature authority: low density lipoprotein receptor-related protein 1
NCBI GeneID: 4035
gene map location: 12q13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001523 (EC: TAS); GO_0002020 (EC: IEA); GO_0004872 (EC: TAS, PMID: 10880251); GO_0005509 (EC: ISS); GO_0005515 (EC: IPI, PMID: 17326667); GO_0005634 (EC: IEA); GO_0005765 (EC: IDA, PMID: 17897319); GO_0005768 (EC: IEA); GO_0005886 (EC: TAS); GO_0005887 (EC: ISS); GO_0005905 (EC: IEA); GO_0006898 (EC: IEA); GO_0007205 (EC: IEA); GO_0007568 (EC: IEA); GO_0007603 (EC: TAS); GO_0008203 (EC: IEA); GO_0008283 (EC: IEA); GO_0010875 (EC: ISS); GO_0014912 (EC: ISS); GO_0030136 (EC: IEA); GO_0030178 (EC: ISS); GO_0030425 (EC: IEA); GO_0030666 (EC: TAS); GO_0032370 (EC: ISS); GO_0032374 (EC: ISS); GO_0032403 (EC: IDA, PMID: 8626514); GO_0032429 (EC: ISS); GO_0032956 (EC: ISS); GO_0034185 (EC: IDA, PMID: 2779654); GO_0034185 (EC: IPI, PMID: 18635818); GO_0035909 (EC: ISS); GO_0042157 (EC: IEA); GO_0042953 (EC: NAS, PMID: 3266596); GO_0042954 (EC: NAS, PMID: 3266596); GO_0043025 (EC: IEA); GO_0043235 (EC: IDA); GO_0043277 (EC: ISS); GO_0043524 (EC: IEA); GO_0044822 (EC: IDA); GO_0051222 (EC: IEA); GO_0070325 (EC: IC, PMID: 18635818); GO_0097242 (EC: TAS, PMID: 19098903); GO_2000587 (EC: ISS)
has PubMed association: PMID: 1281473; 1374383; 1377168; 1423505; 1464627; 1502153; 1698775; 1702392; 1718973; 2112085; 2548950; 2597675; 2779654; 3266596; 7508685; 7510694; 7534747; 7543026; 7721852; 7775583; 7961982; 7989348; 8307199; 8546712; 8626514; 8703036; 8806749; 9045712; 9045716; 9051770; 9252371; 9295345; 9782078; 9804823; 9820815; 9837937; 10318830; 10471328; 10514495; 10608878; 10632583; 10652313; 10747918; 10772929; 10827173; 10880251; 11006321; 11076057; 11100124; 11158305; 11247302; 11248808; 11279011; 11359936; 11421580; 11436125; 11479307; 11560994; 11600564; 11705989; 11720768; 11729193; 11823454; 11854294; 11861214; 11867643; 11907044; 11931574; 11992244; 12069755; 12169628; 12194978; 12212791; 12393177; 12394648; 12402342; 12412500; 12417024; 12473559; 12477932; 12522143; 12522212; 12531796; 12555245; 12637503; 12672816; 12713657; 12732394; 12750160; 12789267; 12793904; 12807892; 12821648; 12857755; 12888553; 12960961; 14585398; 14593097; 14597676; 14645246; 14699139; 14702039; 14739301; 14980518; 14991768; 15001579; 15044004; 15048651; 15131125; 15135046; 15226301; 15231748; 15264223; 15272003; 15288502; 15294142; 15328156; 15591119; 15634227; 15647823; 15705569; 15705932; 15749709; 15769472; 15772078; 15800028; 15863833; 15925094; 15944146; 16040006; 16088940; 16102056; 16167883; 16175004; 16328515; 16335952; 16362633; 16402284; 16407289; 16459332; 16567404; 16606588; 16697011; 16697675; 16751776; 16807059; 16821592; 16839343; 16929535; 16956829; 17012232; 17124247; 17155964; 17203175; 17258834; 17326667; 17360663; 17570828; 17620659; 17694066; 17709443; 17711877; 17889283; 17897319; 17908054; 17942912; 17974965; 18037995; 18156630; 18166789; 18194421; 18231792; 18277139; 18281370; 18288927; 18317248; 18321860; 18373737; 18381291; 18489712; 18635818; 18648652; 18653767; 18683150; 18685438; 18706476; 18834984; 18940800; 18941243; 18990694; 19008962; 19036715; 19036954; 19098903; 19105203; 19176371; 19251705; 19299462; 19336475; 19383717; 19393132; 19420105; 19439404; …
description: low density lipoprotein receptor-related protein 1
database cross reference: Ensembl:ENSG00000123384
database cross reference: HGNC:6692
database cross reference: HPRD:00138
database cross reference: MIM:107770
database cross reference: Vega:OTTHUMG00000044412

LRP6
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ADCAD2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LRP6
full name from nomenclature authority: low density lipoprotein receptor-related protein 6
NCBI GeneID: 4040
gene map location: 12p13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001702 (EC: IBA); GO_0001843 (EC: IBA); GO_0001933 (EC: IMP, PMID: 16365045); GO_0001947 (EC: IEA); GO_0002053 (EC: IEA); GO_0003344 (EC: IBA); GO_0005041 (EC: IDA, PMID: 16263759); GO_0005102 (EC: IPI, PMID: 14739301); GO_0005109 (EC: IPI, PMID: 11029007); GO_0005515 (EC: IPI, PMID: 11029007); GO_0005769 (EC: IDA, Qualifier: colocalizes_with, PMID: 16890161); GO_0005783 (EC: IEA); GO_0005794 (EC: IDA, Qualifier: colocalizes_with, PMID: 16890161); GO_0005886 (EC: IDA, PMID: 16263759); GO_0005901 (EC: IDA, Qualifier: colocalizes_with, PMID: 16890161); GO_0006469 (EC: IMP, PMID: 16365045); GO_0007204 (EC: IEA); GO_0007268 (EC: IBA); GO_0009880 (EC: IBA); GO_0009952 (EC: IBA); GO_0009986 (EC: IDA, PMID: 12897152); GO_0014029 (EC: IDA, PMID: 11029007); GO_0014033 (EC: IDA, PMID: 11029007); GO_0016021 (EC: IEA); GO_0016055 (EC: IDA, PMID: 16263759); GO_0016055 (EC: IMP, PMID: 11029007); GO_0016337 (EC: IEA); GO_0017147 (EC: IPI, PMID: 11029007); GO_0019210 (EC: IMP, PMID: 16365045); GO_0019534 (EC: IMP, PMID: 16564009); GO_0019534 (EC: IMP, Qualifier: NOT, PMID: 18350154); GO_0021587 (EC: IBA); GO_0021794 (EC: IBA); GO_0021795 (EC: IEA); GO_0021861 (EC: IEA); GO_0021874 (EC: IEA); GO_0021943 (EC: IEA); GO_0021987 (EC: IBA); GO_0030278 (EC: IBA); GO_0030326 (EC: IBA); GO_0030901 (EC: IBA); GO_0030917 (EC: IBA); GO_0031410 (EC: IDA, PMID: 16890161); GO_0034185 (EC: IBA); GO_0034392 (EC: IMP, PMID: 15271658); GO_0035115 (EC: IEA); GO_0035116 (EC: IEA); GO_0035261 (EC: IBA); GO_0036342 (EC: IEA); GO_0042074 (EC: IEA); GO_0042475 (EC: IBA); GO_0042733 (EC: IEA); GO_0042803 (EC: IPI, PMID: 12897152); GO_0042813 (EC: IBA); GO_0043025 (EC: IBA); GO_0043065 (EC: IEA); GO_0043235 (EC: IBA); GO_0043434 (EC: IEA); GO_0044332 (EC: IDA, PMID: 11029007); GO_0044335 (EC: IC, PMID: 11029007); GO_0044340 (EC: IC, PMID: 15271658); GO_0045202 (EC: IBA); GO_0045598 (EC: IBA); GO_0045599 (EC: IEA); GO_0045778 (EC: IEA); GO_0045780 (EC: IEA); GO_0045787 (EC: IMP, PMID: 15271658); GO_004589…
has PubMed association: PMID: 8889549; 9704021; 10036184; 11029007; 11357136; 11448771; 11742004; 12121999; 12477932; 12581525; 12857724; 12897152; 14702039; 14739301; 15035989; 15084453; 15271658; 15342556; 15469977; 15489334; 15516984; 15908424; 16263759; 16355283; 16365045; 16384981; 16513652; 16543246; 16564009; 16815997; 16890161; 16989816; 17326769; 17332414; 17376403; 17517621; 17569865; 17698587; 17765217; 17804805; 18077588; 18083125; 18215320; 18350154; 18362152; 18378904; 18406176; 18493104; 18502762; 18505732; 18524778; 18606139; 18676680; 18717822; 18762581; 18772438; 18838381; 18948618; 18981475; 19015224; 19107203; 19170196; 19293931; 19339249; 19453261; 19477926; 19625176; 19667113; 19692168; 19711366; 19801552; 19833493; 19881541; 19898734; 19910923; 19913121; 20053636; 20057906; 20093360; 20128690; 20137080; 20194742; 20227366; 20351274; 20388731; 20390408; 20460648; 20543981; 20628086; 20676368; 20846389; 20926594; 20974802; 21139048; 21245321; 21397183; 21536646; 21887268; 21906983; 21944579; 21963094; 21984209; 22000855; 22000856; 22128165; 22372892; 22393312; 22490400; 22570728; 22575959; 22589387; 22606268; 22645275; 22682247; 22696217; 22871567; 22899650; 22907437; 23000965; 23077088; 23218566; 23302227; 23306204; 23395167; 23638027; 23666756; 23703864; 23754096; 23811937; 23870195; 23959799; 23987510
description: low density lipoprotein receptor-related protein 6
database cross reference: Ensembl:ENSG00000070018
database cross reference: HGNC:6698
database cross reference: HPRD:04617
database cross reference: MIM:603507
database cross reference: Vega:OTTHUMG00000168540

BCAM
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AU
alternative term: CD239
alternative term: LU
alternative term: MSK19
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BCAM
full name from nomenclature authority: basal cell adhesion molecule (Lutheran blood group)
NCBI GeneID: 4059
gene map location: 19q13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004888 (EC: TAS, PMID: 7777537); GO_0005055 (EC: IMP, PMID: 16236823); GO_0005886 (EC: TAS, PMID: 9166867); GO_0005887 (EC: TAS, PMID: 7777537); GO_0007155 (EC: TAS, PMID: 7954395); GO_0007160 (EC: IMP, PMID: 16236823); GO_0007165 (EC: TAS, PMID: 7777537); GO_0009897 (EC: IC, PMID: 16236823); GO_0043236 (EC: IMP, PMID: 16236823); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 2907851; 3810828; 7777537; 7954395; 8781446; 8889548; 9166867; 9192786; 9642222; 11133776; 11319237; 12244066; 12477932; 12493773; 12754519; 14641871; 14755370; 15238148; 15278364; 15342556; 15489334; 15790807; 16236823; 16335952; 16584446; 17087659; 17638854; 18067501; 18302987; 18510579; 18514010; 18635166; 18815288; 18972067; 19056867; 19065527; 19201739; 19667067; 20370913; 20562314; 20566895; 20655789; 21139048; 21434869; 21858073; 22404936; 22941965; 23001842; 23125034; 23160466; 23168236; 23192594; 23406016; 23421542; 24036115
description: basal cell adhesion molecule (Lutheran blood group)
database cross reference: Ensembl:ENSG00000187244
database cross reference: HGNC:6722
database cross reference: HPRD:00197
database cross reference: MIM:612773
database cross reference: Vega:OTTHUMG00000180838

MAOB
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAOB
full name from nomenclature authority: monoamine oxidase B
NCBI GeneID: 4129
NCBI LocusTag: RP1-201D17__B.1
gene map location: Xp11.23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005739 (EC: IDA); GO_0005740 (EC: TAS, PMID: 7063850); GO_0005741 (EC: TAS); GO_0005743 (EC: IEA); GO_0006805 (EC: TAS); GO_0008131 (EC: TAS); GO_0009055 (EC: TAS, PMID: 8602220); GO_0009636 (EC: IEA); GO_0010044 (EC: IEA); GO_0010269 (EC: IEA); GO_0014063 (EC: IEA); GO_0016021 (EC: IEA); GO_0021762 (EC: IEP); GO_0032496 (EC: IEA); GO_0042493 (EC: IEA); GO_0042803 (EC: IEA); GO_0044281 (EC: TAS); GO_0045471 (EC: IEA); GO_0045964 (EC: IEA); GO_0050660 (EC: IEA); GO_0051412 (EC: IEA)
has PubMed association: PMID: 1432104; 2023912; 3387449; 3540317; 4016087; 4687789; 6951409; 7063850; 7499273; 8060341; 8316221; 8515265; 8602220; 8613523; 8665924; 8889548; 9045087; 9596006; 10653595; 11049757; 11171904; 11295131; 11396715; 11753429; 11761322; 11861643; 11956220; 12011284; 12098640; 12136060; 12360111; 12428723; 12465073; 12477932; 12563176; 12732844; 12763335; 12777388; 12815660; 12815741; 12825788; 12855685; 12913124; 12963742; 14659989; 14697881; 14743364; 14962671; 15024015; 15027868; 15028609; 15057517; 15211623; 15247489; 15261699; 15355491; 15461973; 15589121; 15694196; 15699372; 15710600; 15753616; 15772651; 15862518; 15921854; 15955630; 16129825; 16344560; 16366596; 16427095; 16455660; 16484337; 16610949; 16674552; 16807522; 17044053; 17270484; 17289152; 17427196; 17449559; 17628790; 17640790; 17885758; 17918234; 17938636; 18092818; 18205889; 18270970; 18327668; 18405071; 18430257; 18553363; 18832861; 19053775; 19058789; 19086053; 19156168; 19221690; 19268543; 19455600; 19506579; 19598235; 19657584; 19693267; 19789505; 19863190; 19874574; 19913121; 19956754; 20022119; 20127808; 20461808; 20467438; 20479760; 20485326; 20589923; 20603187; 20628086; 20648649; 20734064; 21075085; 21177257; 21359973; 21610556; 21781348; 21786798; 21906983; 21971000; 21971001; 21978362; 21978760; 21988832; 22270014; 22414661; 22974659; 23054588; 23093014; 23319194; 23474901
description: monoamine oxidase B

MAPT
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DDPAC
alternative term: FTDP-17
alternative term: MAPTL
alternative term: MSTD
alternative term: MTBT1
alternative term: MTBT2
alternative term: PPND
alternative term: TAU
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAPT
full name from nomenclature authority: microtubule-associated protein tau
NCBI GeneID: 4137
gene map location: 17q21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000226 (EC: IDA, PMID: 1057175); GO_0001764 (EC: IEA); GO_0005200 (EC: TAS, PMID: 2498079); GO_0005515 (EC: IPI, PMID: 10987820); GO_0005829 (EC: TAS); GO_0005874 (EC: IEA); GO_0005875 (EC: TAS, PMID: 10747907); GO_0005886 (EC: IDA, PMID: 8522593); GO_0006915 (EC: TAS); GO_0006921 (EC: TAS); GO_0007628 (EC: IEA); GO_0008017 (EC: IDA, PMID: 1918161); GO_0008088 (EC: IEA); GO_0010506 (EC: IGI, PMID: 19074461); GO_0017124 (EC: IPI, PMID: 9763511); GO_0019899 (EC: IPI, PMID: 12888622); GO_0019901 (EC: IEA); GO_0030424 (EC: IDA, PMID: 8642405); GO_0030426 (EC: IDA, PMID: 8642405); GO_0031113 (EC: NAS, PMID: 1057175); GO_0031116 (EC: IDA, PMID: 1421571); GO_0032387 (EC: IEA); GO_0034185 (EC: IPI, PMID: 7566652); GO_0034399 (EC: IDA, PMID: 19157893); GO_0045298 (EC: IDA, PMID: 8642405); GO_0045773 (EC: IDA, PMID: 1389180); GO_0047497 (EC: IEA); GO_0048675 (EC: IEA); GO_0048699 (EC: NAS, PMID: 8522593); GO_0060632 (EC: IEA); GO_0071813 (EC: IPI, PMID: 7972031)
has PubMed association: PMID: 1057175; 1181841; 1330687; 1389180; 1420178; 1421571; 1512244; 1713721; 1723470; 1915258; 1918161; 2123288; 2484340; 2495000; 2498079; 2516729; 2833519; 3111527; 3131773; 6304075; 6743699; 7566346; 7566652; 7567473; 7684835; 7706316; 7931292; 7936241; 7972031; 8522593; 8546229; 8620924; 8631898; 8632146; 8642405; 8910513; 8999860; 9147408; 9199504; 9326300; 9353289; 9512010; 9546672; 9565682; 9614189; 9629852; 9636220; 9641683; 9689133; 9735171; 9736630; 9736786; 9763511; 9771888; 9789048; 9832145; 9836646; 9922135; 9973279; 10090741; 10208578; 10214944; 10374757; 10391244; 10393977; 10412802; 10464279; 10489057; 10514099; 10534245; 10604746; 10737616; 10747907; 10762698; 10767321; 10802785; 10822460; 10840038; 10899436; 10899937; 10987820; 11071507; 11089577; 11104762; 11117541; 11117542; 11117553; 11162250; 11166961; 11181841; 11220749; 11255441; 11264299; 11278002; 11303757; 11311121; 11313338; 11391737; 11456301; 11585254; 11601501; 11641718; 11698154; 11698390; 11706972; 11812770; 11826099; 11831025; 11831556; 11837744; 11852060; 11861703; 11889249; 11891833; 11906000; 11912108; 11921059; 11939896; 11958849; 11959122; 11959919; 11971081; 11971082; 11988340; 12000767; 12032355; 12056929; 12070658; 12082079; 12112079; 12144513; 12176984; 12177374; 12198126; 12212558; 12220379; 12226093; 12231446; 12325083; 12368187; 12368474; 12387894; 12387897; 12435421; 12464279; 12470988; 12473774; 12476321; 12477932; 12492138; 12505985; 12509859; 12527113; 12565146; 12573250; 12590615; 12629248; 12641733; 12649279; 12678504; 12710929; 12714745; 12756133; 12765608; 12796837; 12811584; 12826737; 12847166; 12853572; 12872001; 12883828; 12888622; 12911634; 12925374; 12932819; 12937143; 12963086; 12975285; 14503643; 14517953; 14523627; 14572459; 14594945; 14595660; 14600827; 14612456; 14615799; 14627651; 14636947; 14660557; 14697667; 14702039; 14730711; 14761950; 14769047; 14769048; 14962978; 14963027; 14966169; 14967043; 14991810; 14991828; 14991829; 14993287; 14993907; 149…
description: microtubule-associated protein tau
database cross reference: Ensembl:ENSG00000186868
database cross reference: HGNC:6893
database cross reference: HPRD:01142
database cross reference: MIM:157140
database cross reference: Vega:OTTHUMG00000168833

MAT1A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MAT
alternative term: MATA1
alternative term: SAMS
alternative term: SAMS1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAT1A
full name from nomenclature authority: methionine adenosyltransferase I, alpha
NCBI GeneID: 4143
NCBI LocusTag: RP11-36D19.2
gene map location: 10q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000096 (EC: TAS); GO_0004478 (EC: IEA); GO_0005524 (EC: IEA); GO_0005829 (EC: TAS); GO_0006520 (EC: TAS, PMID: 1772450); GO_0006556 (EC: IEA); GO_0006730 (EC: IEA); GO_0006805 (EC: TAS); GO_0032259 (EC: TAS); GO_0034641 (EC: TAS); GO_0044281 (EC: TAS); GO_0046872 (EC: IEA)
has PubMed association: PMID: 1056281; 1683972; 1772450; 3812486; 7213623; 7271238; 7560086; 8314764; 8393662; 8770875; 9042912; 9175157; 9482646; 10677294; 12477932; 15164054; 15489334; 15935930; 16341674; 16385451; 18500573; 19048631; 19161160; 19913121; 20146079; 20201926; 20335551; 20628086; 20634891; 20675163; 21185701; 21678410; 21813468; 21890473; 21906983; 22270009; 22318685; 22807109; 22939629; 22951388; 23000965; 23241961; 23425511
description: methionine adenosyltransferase I, alpha
database cross reference: Ensembl:ENSG00000151224
database cross reference: HGNC:6903
database cross reference: HPRD:02013
database cross reference: MIM:610550
database cross reference: Vega:OTTHUMG00000018613

MBP
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MBP
full name from nomenclature authority: myelin basic protein
NCBI GeneID: 4155
gene map location: 18q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 18
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002020 (EC: IEA); GO_0005515 (EC: IPI, PMID: 17064692); GO_0005634 (EC: IEA); GO_0005886 (EC: IEA); GO_0006955 (EC: TAS, PMID: 7504278); GO_0007268 (EC: TAS, PMID: 2434243); GO_0007417 (EC: TAS, PMID: 2434243); GO_0008366 (EC: TAS, PMID: 2434243); GO_0009636 (EC: IEA); GO_0019911 (EC: IEA); GO_0021762 (EC: IEP); GO_0033269 (EC: IEA); GO_0042552 (EC: IEA); GO_0043025 (EC: IEA); GO_0043218 (EC: IEA); GO_0050771 (EC: IEA); GO_0061024 (EC: IEA)
has PubMed association: PMID: 1689270; 2413024; 2414074; 2425357; 2426402; 2427738; 2434243; 2437795; 2442403; 2449425; 2466844; 2467009; 2472816; 4099924; 4108501; 4924231; 5128665; 6083474; 6201481; 7504278; 7544282; 7574672; 7665586; 7685161; 8170997; 8375396; 8537403; 8544862; 8647104; 8786845; 8798720; 8846788; 8889548; 9020143; 9136767; 9155018; 9207191; 9628874; 9782128; 9792705; 9873047; 10339476; 10346818; 10371216; 10383403; 10390541; 10523312; 10708586; 10910078; 10947953; 10958680; 10980603; 11080454; 11120354; 11124993; 11152681; 11258664; 11295122; 11402450; 11500515; 11570821; 11641781; 11683387; 11864968; 11875070; 11940329; 11964256; 12101123; 12237860; 12377379; 12429732; 12477932; 12618862; 12760422; 12939427; 12955071; 12965257; 14530346; 14579272; 14594813; 14702039; 14702098; 14714495; 14743429; 15009677; 15147269; 15328539; 15380617; 15489334; 15728454; 15791647; 15797222; 15870294; 15927069; 16079912; 16216881; 16269541; 16387849; 16412431; 16441258; 16712791; 16713569; 16842822; 16871440; 16900754; 17064692; 17081983; 17259179; 17260967; 17331951; 17351112; 17415991; 17584768; 17599067; 17622942; 17690840; 17706965; 17823288; 17906618; 18067995; 18284662; 18543229; 18663124; 18713991; 18720029; 18802067; 19014520; 19034380; 19053745; 19110265; 19154657; 19293155; 19372141; 19385666; 19423540; 19468823; 19570024; 19663312; 19690890; 19692707; 19826009; 19910486; 19950581; 20212043; 20406964; 20438785; 20471030; 20629634; 20807757; 21203542; 21312222; 21315177; 21551065; 21601398; 21609718; 21673997; 21806997; 21860087; 21898163; 22258479; 22496821; 22538354; 22542401; 22705344; 22888134; 22890910; 22939629; 22968126; 23166209; 23264040; 23315809; 23510371; 23520443; 23524951; 23726766
description: myelin basic protein

MEF2C
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: C5DELq14.3
alternative term: DEL5q14.3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MEF2C
full name from nomenclature authority: myocyte enhancer factor 2C
NCBI GeneID: 4208
gene map location: 5q14.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IMP, PMID: 18079734); GO_0000165 (EC: IDA, PMID: 9858528); GO_0000165 (EC: IMP, PMID: 11160896); GO_0000977 (EC: IDA, PMID: 8455629); GO_0000981 (EC: ISS); GO_0000983 (EC: IDA, PMID: 8455629); GO_0000987 (EC: IEA); GO_0001046 (EC: IEA); GO_0001077 (EC: IDA, PMID: 15486975); GO_0001568 (EC: ISS); GO_0001649 (EC: ISS); GO_0001782 (EC: ISS); GO_0001947 (EC: ISS); GO_0001958 (EC: ISS); GO_0001974 (EC: ISS); GO_0002062 (EC: ISS); GO_0002224 (EC: TAS); GO_0002467 (EC: ISS); GO_0002634 (EC: ISS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0003138 (EC: ISS); GO_0003139 (EC: ISS); GO_0003151 (EC: ISS); GO_0003185 (EC: ISS); GO_0003211 (EC: ISS); GO_0003677 (EC: IDA, PMID: 11744164); GO_0003680 (EC: IDA, PMID: 15486975); GO_0003682 (EC: IEA); GO_0003700 (EC: IDA, PMID: 16043483); GO_0003705 (EC: IEA); GO_0005515 (EC: IPI, PMID: 15486975); GO_0005634 (EC: IDA, PMID: 11744164); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA, PMID: 8455629); GO_0006915 (EC: IEA); GO_0006959 (EC: ISS); GO_0007399 (EC: TAS, PMID: 8455629); GO_0007507 (EC: IEP, PMID: 10458488); GO_0007507 (EC: ISS); GO_0007507 (EC: NAS, PMID: 15486975); GO_0007517 (EC: TAS, PMID: 8455629); GO_0007519 (EC: ISS); GO_0007521 (EC: ISS); GO_0007611 (EC: ISS); GO_0009615 (EC: IEP); GO_0010613 (EC: IEA); GO_0010628 (EC: IDA); GO_0010629 (EC: ISS); GO_0010694 (EC: ISS); GO_0014033 (EC: ISS); GO_0014898 (EC: IEA); GO_0014902 (EC: IEP, PMID: 8455629); GO_0016607 (EC: IDA, PMID: 18079734); GO_0021542 (EC: IEA); GO_0030017 (EC: IEA); GO_0030182 (EC: IEP, PMID: 8455629); GO_0030182 (EC: ISS); GO_0030220 (EC: ISS); GO_0030224 (EC: IEA); GO_0030279 (EC: IDA, PMID: 17696759); GO_0030318 (EC: ISS); GO_0030501 (EC: ISS); GO_0030890 (EC: ISS); GO_0033197 (EC: IEA); GO_0033613 (EC: IPI, PMID: 11160896); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035198 (EC: IDA); GO_0035666 (EC: TAS); GO_0035690 (EC: ISS); GO_0035984 (EC: ISS); …
has PubMed association: PMID: 7679508; 8455629; 8548800; 8575763; 8575784; 8663403; 8900141; 8948587; 9001254; 9069290; 9384584; 9418854; 9748305; 9753748; 9770491; 9798649; 9857019; 9858528; 10082551; 10330143; 10458488; 10523670; 10737771; 10790371; 10805738; 11160896; 11279209; 11486037; 11504882; 11535832; 11554755; 11744164; 11792813; 11809751; 12061776; 12130539; 12135755; 12376544; 12477932; 12659851; 12709441; 12861002; 15084602; 15140898; 15276183; 15340086; 15342556; 15486975; 15561718; 15743821; 15743823; 15831463; 15834131; 15923648; 15964851; 16043483; 16469744; 16478538; 16504037; 16510869; 17611778; 17696759; 17903302; 18029348; 18067759; 18079734; 18332106; 18463162; 18588859; 18660489; 18950845; 19011954; 19065516; 19093215; 19453261; 19553684; 19592390; 19720801; 19751190; 19801982; 19828686; 19913121; 20211142; 20333642; 20412115; 20513142; 20610535; 20628086; 20709755; 20881960; 20936779; 21060863; 21481790; 21533022; 21652706; 21849497; 21890473; 21901155; 21906983; 21988832; 22073279; 22139419; 22275376; 22363514; 22449245; 22504420; 22670137; 22718505; 22798246; 22997707; 23001426; 23174904; 23226416; 23382706; 23389741; 23400010; 23402836; 23468913; 23572186; 23776548; 24008018; 24290359
description: myocyte enhancer factor 2C
database cross reference: Ensembl:ENSG00000081189
database cross reference: HGNC:6996
database cross reference: HPRD:02809
database cross reference: MIM:600662
database cross reference: Vega:OTTHUMG00000162634

MIF
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GIF
alternative term: GLIF
alternative term: MMIF
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MIF
full name from nomenclature authority: macrophage migration inhibitory factor (glycosylation-inhibiting factor)
NCBI GeneID: 4282
gene map location: 22q11.23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001516 (EC: IDA, PMID: 12782713); GO_0002906 (EC: IEA); GO_0004167 (EC: IDA, PMID: 17526494); GO_0005102 (EC: IPI, PMID: 12782713); GO_0005125 (EC: IDA, PMID: 12782713); GO_0005126 (EC: IPI, PMID: 17045821); GO_0005515 (EC: IPI, PMID: 12681488); GO_0005576 (EC: IDA, PMID: 12782713); GO_0005615 (EC: IEA); GO_0005737 (EC: IEA); GO_0006954 (EC: IEA); GO_0007166 (EC: IDA, PMID: 12782713); GO_0007569 (EC: IEA); GO_0008283 (EC: IDA, PMID: 12782713); GO_0009986 (EC: IDA, PMID: 12782713); GO_0010629 (EC: IDA, PMID: 10562313); GO_0010739 (EC: IDA, PMID: 17045821); GO_0019752 (EC: IDA, PMID: 12782713); GO_0030330 (EC: IEA); GO_0030890 (EC: IDA, PMID: 12782713); GO_0031666 (EC: IEA); GO_0032269 (EC: IEA); GO_0033033 (EC: IEA); GO_0033138 (EC: IDA, PMID: 17045821); GO_0042056 (EC: IDA, PMID: 19602265); GO_0042327 (EC: IDA, PMID: 12782713); GO_0043030 (EC: NAS, PMID: 12782713); GO_0043066 (EC: IDA, PMID: 12782713); GO_0043406 (EC: IEA); GO_0043518 (EC: IDA, PMID: 17045821); GO_0045087 (EC: IEA); GO_0048146 (EC: IDA, PMID: 12782713); GO_0050178 (EC: IDA, PMID: 16285950); GO_0050715 (EC: IDA, PMID: 19602265); GO_0050731 (EC: IDA, PMID: 17045821); GO_0050918 (EC: IDA, PMID: 19602265); GO_0061078 (EC: IEA); GO_0061081 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070207 (EC: IPI, PMID: 17526494); GO_0070374 (EC: IDA, PMID: 12782713); GO_0071157 (EC: IDA, PMID: 10562313); GO_0090238 (EC: IEA); GO_0090344 (EC: IDA, PMID: 10562313); GO_1902166 (EC: IDA, PMID: 17045821); GO_2000343 (EC: IEA)
has PubMed association: PMID: 1286669; 2552447; 3917866; 7558020; 7679497; 7683862; 7947826; 8188240; 8234256; 8289313; 8601455; 8610159; 8643551; 8647256; 8766818; 8988336; 9002552; 9006339; 9027512; 10334104; 10353846; 10562313; 11089976; 11170644; 11259268; 11508429; 11875000; 11920501; 11978887; 11985788; 11997397; 12009356; 12032852; 12070782; 12109441; 12126556; 12180727; 12186913; 12218292; 12218308; 12235522; 12355488; 12402212; 12445161; 12477932; 12480958; 12507885; 12576459; 12607777; 12612911; 12615835; 12626594; 12631237; 12665801; 12667094; 12681488; 12738641; 12740374; 12746913; 12782713; 12796500; 12822893; 12847682; 12965208; 14502271; 14551601; 14581488; 14607690; 14736878; 14760795; 14962818; 15018649; 15065001; 15146413; 15146431; 15170913; 15216464; 15231747; 15286457; 15292349; 15304087; 15308783; 15461802; 15472203; 15489334; 15545061; 15545824; 15576462; 15585204; 15585220; 15592455; 15612021; 15630728; 15659324; 15757663; 15800984; 15815686; 15820792; 15838879; 15910495; 15910597; 16000172; 16051683; 16085663; 16115023; 16133063; 16169070; 16179637; 16189514; 16200611; 16205314; 16220288; 16224818; 16243796; 16247506; 16285950; 16314470; 16314559; 16317091; 16369812; 16385258; 16388506; 16488392; 16527487; 16538639; 16677407; 16709839; 16724072; 16767681; 16780713; 16807115; 16820919; 16839849; 16854377; 16861224; 16872482; 16893895; 16929348; 17005573; 17029206; 17045821; 17075815; 17108334; 17142775; 17166737; 17172590; 17181929; 17206642; 17215861; 17224449; 17353931; 17435771; 17438452; 17438455; 17495357; 17526494; 17541237; 17559578; 17591062; 17592555; 17620429; 17658526; 17706208; 17709373; 17712545; 17728788; 17763209; 17786285; 17854804; 17854909; 17869648; 17906677; 17912466; 18034423; 18037272; 18054247; 18060744; 18074864; 18078632; 18081874; 18097599; 18165264; 18171527; 18171602; 18177450; 18228042; 18235500; 18239193; 18242614; 18261992; 18270460; 18356846; 18362243; 18426738; 18466513; 18469521; 18474653; 18490733; 18493321; 18502749; 18618071; 186…
description: macrophage migration inhibitory factor (glycosylation-inhibiting factor)
database cross reference: HGNC:7097
database cross reference: HPRD:01091
database cross reference: MIM:153620

MME
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CALLA
alternative term: CD10
alternative term: NEP
alternative term: SFE
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MME
full name from nomenclature authority: membrane metallo-endopeptidase
NCBI GeneID: 4311
gene map location: 3q25.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001822 (EC: IEP); GO_0002003 (EC: TAS); GO_0004175 (EC: IDA, PMID: 15283675); GO_0004175 (EC: IMP, PMID: 2531377); GO_0004222 (EC: IMP, PMID: 2521388); GO_0005515 (EC: IPI, PMID: 17342744); GO_0005737 (EC: IDA); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0005887 (EC: NAS, PMID: 2521388); GO_0005903 (EC: IDA); GO_0006508 (EC: IDA); GO_0006518 (EC: ISS); GO_0008021 (EC: ISS); GO_0008270 (EC: IDA, PMID: 8168535); GO_0016021 (EC: NAS, PMID: 2968607); GO_0019233 (EC: ISS); GO_0030424 (EC: ISS); GO_0030425 (EC: ISS); GO_0042277 (EC: ISS); GO_0044267 (EC: TAS); GO_0044306 (EC: ISS); GO_0045202 (EC: ISS); GO_0046449 (EC: IMP); GO_0050435 (EC: ISS); GO_0070062 (EC: IDA, PMID: 19056867); GO_0071345 (EC: IDA); GO_0071492 (EC: IDA); GO_0071493 (EC: IDA); GO_0090399 (EC: IEP)
has PubMed association: PMID: 1660144; 2201681; 2417254; 2521237; 2521388; 2528730; 2531377; 2612455; 2736261; 2968607; 2971756; 2972276; 2984462; 2994530; 3157879; 3162217; 7532408; 8003005; 8168535; 8631021; 8687431; 8943850; 9232196; 9247159; 9313778; 9659899; 9857225; 10669592; 11104793; 11140838; 11170145; 11367540; 11849775; 11906289; 12070597; 12087466; 12102663; 12105192; 12140380; 12150966; 12203213; 12387451; 12393702; 12447961; 12477932; 12485446; 12527400; 12529960; 12657655; 12754344; 12754519; 12785004; 14550292; 14673956; 14739539; 14747736; 14749444; 14767532; 14968440; 15047060; 15100223; 15205682; 15217945; 15283675; 15286660; 15294904; 15464186; 15469471; 15489334; 15502805; 15548496; 15578072; 15668537; 15720419; 15785408; 15860464; 15870909; 15945081; 16123216; 16226260; 16344560; 16400325; 16652149; 16700740; 16722930; 16857799; 16877296; 16900210; 16900384; 16940054; 16943769; 16948517; 16984256; 17101991; 17207277; 17220478; 17294442; 17296585; 17335564; 17342744; 17363457; 17591969; 17662271; 17712175; 17845760; 17876294; 17885484; 17906676; 17928142; 17953966; 18042078; 18092952; 18182043; 18292286; 18370954; 18393807; 18518902; 18539150; 18545147; 18602473; 18605079; 18619643; 18806483; 19019493; 19047112; 19056867; 19057576; 19127446; 19152193; 19196432; 19250583; 19287335; 19288202; 19326964; 19437324; 19448593; 19515046; 19575892; 19606063; 19656156; 19661328; 19752720; 19787248; 19816087; 19817893; 19864659; 19897485; 19925052; 19948975; 19961253; 20014550; 20051779; 20051780; 20061637; 20079015; 20105452; 20175824; 20184665; 20204382; 20376800; 20390424; 20459800; 20468064; 20506111; 20546336; 20574156; 20663017; 20685603; 20711432; 20716621; 20856894; 20858953; 20886092; 20947507; 20957047; 21052031; 21076839; 21225496; 21315759; 21365649; 21425402; 21499231; 21515054; 21585282; 21609487; 21651905; 21666788; 21677537; 21681600; 21775056; 21804528; 21835428; 21877416; 21883368; 21963094; 21988858; 21989348; 22006372; 22014058; 22183801; 22257901; 22261707; 2…
description: membrane metallo-endopeptidase
database cross reference: Ensembl:ENSG00000196549
database cross reference: HGNC:7154
database cross reference: HPRD:00392
database cross reference: MIM:120520
database cross reference: Vega:OTTHUMG00000158455

MMP2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CLG4
alternative term: CLG4A
alternative term: MMP-II
alternative term: MONA
alternative term: TBE-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MMP2
full name from nomenclature authority: matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
NCBI GeneID: 4313
gene map location: 16q13-q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001525 (EC: IEA); GO_0001666 (EC: IEA); GO_0001955 (EC: IEA); GO_0001957 (EC: IEA); GO_0004222 (EC: IEA); GO_0004252 (EC: TAS); GO_0005515 (EC: IPI); GO_0005576 (EC: TAS); GO_0005578 (EC: IEA); GO_0005615 (EC: IDA, PMID: 18492766); GO_0005634 (EC: IEA); GO_0005739 (EC: IEA); GO_0005886 (EC: IEA); GO_0006508 (EC: TAS, PMID: 2834383); GO_0007566 (EC: IEA); GO_0008270 (EC: IEA); GO_0022617 (EC: TAS); GO_0030017 (EC: IEA); GO_0030198 (EC: TAS); GO_0030574 (EC: TAS); GO_0044267 (EC: TAS); GO_0060325 (EC: IEA); GO_0060346 (EC: IEA); GO_0071230 (EC: IEA)
has PubMed association: PMID: 1460022; 1846313; 1851724; 2071140; 2158484; 2162831; 2834383; 7523391; 7583664; 7683678; 7694569; 7782289; 7935812; 7947821; 7998967; 8549817; 8663297; 8663332; 8692946; 8862926; 9119036; 9148753; 9182583; 9343394; 9344465; 9438380; 9640131; 9699154; 9737711; 9853262; 9933646; 10196161; 10356396; 10419448; 10551873; 10652000; 10652271; 10900205; 10947989; 10986281; 10991943; 11114309; 11134507; 11168762; 11179305; 11220743; 11368514; 11382769; 11420387; 11431697; 11485914; 11571304; 11598182; 11728453; 11748988; 11756567; 11762702; 11782389; 11790786; 11792711; 11824472; 11833938; 11839588; 11844598; 11854622; 11889208; 11895494; 11918086; 11920503; 11928808; 11928813; 11929863; 11935310; 11948127; 11956628; 11961384; 12007723; 12023034; 12029498; 12032297; 12034345; 12039803; 12077518; 12085233; 12087091; 12103254; 12115722; 12122099; 12147229; 12147339; 12149192; 12193399; 12194986; 12198653; 12225805; 12235151; 12371906; 12372458; 12374789; 12376362; 12393408; 12393872; 12431239; 12438229; 12439941; 12451991; 12470034; 12471459; 12473650; 12475252; 12477932; 12479097; 12486137; 12522578; 12559990; 12569569; 12586836; 12587534; 12589095; 12601782; 12602913; 12614934; 12615834; 12632066; 12632084; 12642591; 12651627; 12657623; 12676736; 12684625; 12753080; 12764090; 12810672; 12832446; 12845641; 12861074; 12873995; 12878157; 12879005; 12880418; 12914776; 12939660; 12952836; 12967855; 12970394; 12970724; 14500349; 14519487; 14520690; 14580155; 14583471; 14604886; 14614057; 14644155; 14644777; 14661256; 14666611; 14679018; 14694003; 14697951; 14710472; 14713104; 14732714; 14744781; 14766248; 14871985; 14973177; 14981939; 14982725; 14983226; 14990702; 14990972; 14996438; 15004438; 15009703; 15015767; 15051038; 15056834; 15067014; 15102849; 15146192; 15165255; 15201662; 15241180; 15248212; 15248826; 15250832; 15254682; 15255544; 15265790; 15271946; 15277330; 15280384; 15280448; 15317806; 15317818; 15351863; 15375490; 15381707; 15449075; 15475447; 15485653; 15489…
description: matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
database cross reference: Ensembl:ENSG00000087245
database cross reference: HGNC:7166
database cross reference: HPRD:00386
database cross reference: MIM:120360
database cross reference: Vega:OTTHUMG00000133202

MMP3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CHDS6
alternative term: MMP-3
alternative term: SL-1
alternative term: STMY
alternative term: STMY1
alternative term: STR1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MMP3
full name from nomenclature authority: matrix metallopeptidase 3 (stromelysin 1, progelatinase)
NCBI GeneID: 4314
gene map location: 11q22.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004222 (EC: IEA); GO_0005509 (EC: IEA); GO_0005576 (EC: TAS); GO_0005578 (EC: IEA); GO_0005615 (EC: TAS, PMID: 3360803); GO_0006508 (EC: TAS, PMID: 3360803); GO_0008270 (EC: IEA); GO_0022617 (EC: TAS); GO_0030198 (EC: TAS); GO_0030334 (EC: IEA); GO_0030574 (EC: TAS); GO_0071230 (EC: IEA)
has PubMed association: PMID: 2383557; 2605216; 2785989; 3030290; 3360803; 3477804; 7523391; 7656014; 7694569; 7998967; 8125298; 8216228; 8486377; 8535233; 8662692; 8740360; 8921407; 8957070; 9083493; 9148753; 9288970; 9548733; 9558113; 9733482; 9737711; 9760240; 9792098; 9827994; 9873489; 9888835; 10419448; 10422833; 10543949; 10639284; 10669564; 10877850; 10922468; 10947989; 10967118; 10986281; 11116068; 11297453; 11327577; 11375993; 11380116; 11438501; 11485914; 11546917; 11751414; 11824472; 11827795; 11836255; 11841344; 11841844; 11977998; 11982752; 11988625; 12009331; 12034345; 12034715; 12054564; 12054629; 12071839; 12103254; 12124858; 12149192; 12204805; 12205736; 12229968; 12230559; 12364729; 12385578; 12432557; 12473595; 12477932; 12477941; 12485468; 12572877; 12634064; 12651627; 12727228; 12736398; 12750310; 12761889; 12784383; 12810672; 12821236; 12832381; 12834347; 12837283; 12866026; 12867428; 12876636; 12880418; 12952836; 13129650; 14712311; 14715248; 14718574; 14984923; 14998290; 15009479; 15033492; 15070833; 15084374; 15094779; 15102660; 15142265; 15161710; 15172469; 15194213; 15203551; 15234427; 15274394; 15288468; 15290728; 15308783; 15312099; 15319295; 15319302; 15337261; 15342709; 15355616; 15383690; 15389640; 15467919; 15474069; 15489334; 15528217; 15529384; 15546966; 15610507; 15640153; 15665388; 15667946; 15701845; 15716694; 15748780; 15757531; 15763339; 15788677; 15823277; 15863497; 15879464; 15894268; 15944607; 15955221; 15972662; 15993717; 16080875; 16082623; 16088212; 16100452; 16102106; 16158251; 16202315; 16238676; 16278009; 16302209; 16311244; 16323393; 16356191; 16405530; 16424284; 16430740; 16516860; 16532917; 16615041; 16629857; 16677108; 16739355; 16802342; 16822591; 16871440; 16899023; 16904077; 16905683; 16919028; 16935611; 16937230; 16972019; 16972255; 16972994; 16984617; 16998253; 17000679; 17000887; 17003494; 17024375; 17027562; 17033924; 17058024; 17065356; 17077200; 17125518; 17137622; 17145822; 17151781; 17178858; 17181997; 17182940; 17198194; 1720…
description: matrix metallopeptidase 3 (stromelysin 1, progelatinase)
database cross reference: Ensembl:ENSG00000149968
database cross reference: HGNC:7173
database cross reference: HPRD:01703
database cross reference: MIM:185250
database cross reference: Vega:OTTHUMG00000048254

MMP9
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CLG4B
alternative term: GELB
alternative term: MANDP2
alternative term: MMP-9
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MMP9
full name from nomenclature authority: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
NCBI GeneID: 4318
gene map location: 20q11.2-q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001501 (EC: IEA); GO_0001503 (EC: IEA); GO_0004222 (EC: IDA, PMID: 16192646); GO_0005515 (EC: IPI, PMID: 16512877); GO_0005518 (EC: TAS, PMID: 2251898); GO_0005576 (EC: TAS); GO_0005578 (EC: IEA); GO_0005615 (EC: IDA, PMID: 2251898); GO_0006508 (EC: IDA, PMID: 2551898); GO_0007566 (EC: IEA); GO_0008270 (EC: TAS, PMID: 2251898); GO_0022617 (EC: TAS); GO_0030198 (EC: TAS); GO_0030225 (EC: TAS, PMID: 2251898); GO_0030574 (EC: TAS); GO_0042802 (EC: IPI); GO_0043065 (EC: IEA); GO_0050900 (EC: IEA); GO_0051549 (EC: IMP, PMID: 17704059)
has PubMed association: PMID: 1281792; 1371271; 1400481; 1645657; 1653055; 1653238; 1851724; 1932376; 2158484; 2251898; 2551898; 7669817; 7694569; 7762981; 7896811; 8012988; 8216228; 8426746; 8568270; 8691515; 8978762; 9261109; 9268487; 9344465; 9360944; 9378998; 9578462; 9590175; 9789069; 9878537; 10095777; 10339412; 10389762; 10419448; 10580107; 10598806; 10636480; 10642956; 10644727; 10652271; 10706134; 10796887; 10859319; 10900205; 10988146; 11023497; 11081634; 11134254; 11168762; 11179305; 11279011; 11410119; 11468147; 11486009; 11546917; 11557670; 11576356; 11606713; 11675412; 11688724; 11708786; 11742492; 11756567; 11780052; 11781819; 11813159; 11827795; 11827968; 11830485; 11833938; 11839588; 11839746; 11854622; 11875051; 11876767; 11890521; 11916008; 11920503; 11920505; 11935310; 11940298; 11956628; 11958288; 11971760; 11978564; 11986939; 11994547; 11999552; 12004062; 12029498; 12034345; 12050187; 12051944; 12054499; 12062817; 12063180; 12077439; 12081477; 12082590; 12082592; 12084167; 12103254; 12105194; 12126625; 12127674; 12183836; 12193399; 12205736; 12208863; 12219015; 12231534; 12235127; 12235151; 12356580; 12372334; 12376362; 12398893; 12414663; 12431239; 12431981; 12437116; 12443715; 12444074; 12452001; 12464265; 12471459; 12477932; 12479097; 12479099; 12559990; 12569569; 12586837; 12587534; 12589095; 12606037; 12612199; 12615834; 12626459; 12642591; 12651627; 12663332; 12668489; 12671895; 12704537; 12712078; 12717622; 12717827; 12724312; 12727228; 12728308; 12745093; 12750540; 12753719; 12769333; 12789238; 12791318; 12810681; 12811828; 12824186; 12830465; 12847101; 12850503; 12861851; 12865405; 12866035; 12874388; 12879005; 12880418; 12914776; 12921631; 12947332; 12949792; 12950257; 12952836; 12958623; 12960156; 12960961; 12967855; 12970724; 14500349; 14520690; 14550288; 14550924; 14551878; 14561155; 14581136; 14605329; 14607966; 14624478; 14633819; 14644158; 14661062; 14661256; 14675172; 14676438; 14681642; 14687896; 14697951; 14705229; 14719079; 14744773; 14766231; 1476…
description: matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
database cross reference: Ensembl:ENSG00000100985
database cross reference: HGNC:7176
database cross reference: HPRD:00387
database cross reference: MIM:120361
database cross reference: Vega:OTTHUMG00000033044

MMP10
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SL-2
alternative term: STMY2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MMP10
full name from nomenclature authority: matrix metallopeptidase 10 (stromelysin 2)
NCBI GeneID: 4319
gene map location: 11q22.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004222 (EC: IEA); GO_0005509 (EC: IEA); GO_0005576 (EC: TAS); GO_0005578 (EC: IEA); GO_0005615 (EC: TAS, PMID: 2844164); GO_0006508 (EC: TAS, PMID: 2844164); GO_0008270 (EC: IEA); GO_0022617 (EC: TAS); GO_0030198 (EC: TAS); GO_0030334 (EC: IEA); GO_0030574 (EC: TAS)
has PubMed association: PMID: 1874716; 2369069; 2605216; 2844164; 7632822; 7694569; 8003069; 8125298; 8144618; 8349617; 8631328; 8921407; 9042108; 9261109; 9427548; 9578462; 9662124; 10419448; 10472874; 10986281; 12477932; 15095982; 15288123; 15371548; 15375490; 15489334; 15944607; 16054593; 16331256; 16516860; 16580524; 17009259; 17543340; 17695449; 18035073; 18427549; 18617643; 19317417; 19489686; 19601983; 19695094; 19762781; 19913121; 19921252; 19935709; 20215736; 20219015; 20432469; 20452482; 20453000; 20484597; 20584750; 20587546; 20628086; 20673868; 20936527; 21925226; 21998657; 22022614; 22104553; 22121946; 22427646; 22492089; 22524815; 22545096; 22821423; 23098370; 23412934; 23535732; 23742289; 24255036; 24327153
description: matrix metallopeptidase 10 (stromelysin 2)
database cross reference: Ensembl:ENSG00000166670
database cross reference: HGNC:7156
database cross reference: HPRD:01704
database cross reference: MIM:185260
database cross reference: Vega:OTTHUMG00000168083

MPO
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MPO
full name from nomenclature authority: myeloperoxidase
NCBI GeneID: 4353
gene map location: 17q23.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001878 (EC: IEA); GO_0002149 (EC: IEA); GO_0002679 (EC: IEA); GO_0003682 (EC: TAS, PMID: 2829220); GO_0004601 (EC: IDA, PMID: 10772654); GO_0005615 (EC: IDA, PMID: 10772654); GO_0005634 (EC: TAS, PMID: 2829220); GO_0005739 (EC: IEA); GO_0005764 (EC: TAS, PMID: 8621627); GO_0006952 (EC: TAS, PMID: 8621627); GO_0006979 (EC: TAS, PMID: 2903767); GO_0007568 (EC: IEA); GO_0008201 (EC: IDA, PMID: 11907569); GO_0009612 (EC: IEA); GO_0019430 (EC: IEA); GO_0020037 (EC: IEA); GO_0030141 (EC: IDA, PMID: 11907569); GO_0032094 (EC: IEA); GO_0032496 (EC: IEA); GO_0034374 (EC: IDA, PMID: 10772654); GO_0042582 (EC: IDA, PMID: 2981589); GO_0042744 (EC: IDA, PMID: 10772654); GO_0043066 (EC: TAS, PMID: 10801811); GO_0044130 (EC: IEA); GO_0046872 (EC: IEA); GO_0050832 (EC: IEA); GO_0055114 (EC: IDA, PMID: 10772654); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1320128; 1334087; 1703177; 2154223; 2444596; 2552418; 2820530; 2829220; 2884926; 2903767; 2981589; 3029127; 3031585; 3654979; 7530510; 7809065; 7840679; 7904599; 8037771; 8078496; 8142659; 8383257; 8390465; 8530055; 8621627; 8718890; 9097926; 9175709; 9354683; 9637725; 10766826; 10772654; 10777476; 10801811; 10828600; 11087769; 11090610; 11147929; 11161635; 11179831; 11423389; 11434421; 11705390; 11774269; 11794452; 11811524; 11813987; 11840286; 11861298; 11895912; 11907569; 11943609; 11956078; 11960308; 11981455; 11986950; 12027420; 12052532; 12057865; 12089442; 12111688; 12135010; 12164325; 12209361; 12355548; 12393699; 12397651; 12432558; 12460800; 12477932; 12496042; 12496043; 12515618; 12565898; 12606047; 12694338; 12707270; 12729191; 12773517; 12782337; 12792137; 12800195; 12810834; 12818404; 12861032; 12915675; 12946561; 12950060; 12952835; 12969520; 14580687; 14617020; 14626895; 14646692; 14668325; 14716779; 14729580; 14730210; 14761515; 14972011; 15006595; 15023809; 15031357; 15068388; 15108282; 15159316; 15184258; 15196853; 15199549; 15203186; 15222689; 15255951; 15299090; 15304260; 15331175; 15350145; 15379210; 15492293; 15504976; 15507752; 15507753; 15507754; 15507759; 15507760; 15507769; 15507770; 15507771; 15536330; 15538122; 15600254; 15661916; 15705913; 15714076; 15718477; 15734083; 15829318; 15850382; 15884126; 15885363; 15894800; 15901995; 15911707; 15967795; 15996936; 16084535; 16107886; 16148002; 16157195; 16170238; 16195240; 16221222; 16267254; 16289072; 16297214; 16326702; 16335952; 16385446; 16430221; 16476719; 16484808; 16497665; 16504169; 16543247; 16606792; 16641309; 16732739; 16740002; 16758302; 16829688; 16844322; 16883063; 16901848; 16956579; 17017121; 17042493; 17119198; 17145829; 17149600; 17159117; 17161406; 17178637; 17209550; 17259657; 17304047; 17337886; 17355643; 17381162; 17424838; 17428572; 17438335; 17440118; 17451207; 17479404; 17483704; 17521322; 17549373; 17582430; 17595772; 17601350; 17613595; 17650507; 17701359; 1770…
description: myeloperoxidase

MPST
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MST
alternative term: TST2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MPST
full name from nomenclature authority: mercaptopyruvate sulfurtransferase
NCBI GeneID: 4357
NCBI LocusTag: LL22NC01-146D10.4
gene map location: 22q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004792 (EC: IEA); GO_0005739 (EC: IEA); GO_0009440 (EC: TAS, PMID: 9070219); GO_0009636 (EC: TAS, PMID: 9070219); GO_0016784 (EC: IEA); GO_0030054 (EC: IEA); GO_0043005 (EC: ISS); GO_0045202 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070814 (EC: ISS)
has PubMed association: PMID: 1953758; 9070219; 10591208; 12477932; 14702039; 15461802; 15489334; 16545926; 18029348; 19056867; 19615732; 19695240; 20446008; 20877624; 21906983; 21963094; 22505724; 22939629; 23000965; 23698001
description: mercaptopyruvate sulfurtransferase
database cross reference: Ensembl:ENSG00000128309
database cross reference: HGNC:7223
database cross reference: HPRD:11896
database cross reference: MIM:602496
database cross reference: Vega:OTTHUMG00000150543

MSRA
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PMSR
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MSRA
full name from nomenclature authority: methionine sulfoxide reductase A
NCBI GeneID: 4482
gene map location: 8p23.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005634 (EC: IEA); GO_0005739 (EC: IEA); GO_0006464 (EC: TAS, PMID: 10452521); GO_0006555 (EC: TAS, PMID: 10452521); GO_0006979 (EC: IEA); GO_0008113 (EC: IEA); GO_0016020 (EC: IEA); GO_0030091 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 8622914; 10452521; 12039877; 12477932; 12693988; 14759519; 15199188; 15489334; 15680232; 16162094; 16257642; 16364291; 16480945; 17601350; 17784942; 17943184; 18506707; 18845237; 18977241; 19056867; 19085252; 19237503; 19430479; 19542914; 19557161; 19747232; 19844733; 19913121; 20368336; 20379614; 20421936; 20452100; 20617525; 20628086; 20689807; 20703240; 20724581; 20877624; 20937881; 21079812; 21139048; 21674055; 21679298; 21890473; 22438829; 22634633; 22657383; 22688191; 22867795; 23049088; 23244167; 23415806; 23568457; 24250222
description: methionine sulfoxide reductase A
database cross reference: Ensembl:ENSG00000175806
database cross reference: HGNC:7377
database cross reference: HPRD:03152
database cross reference: MIM:601250
database cross reference: Vega:OTTHUMG00000090517

COX1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: COI
alternative term: MTCO1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MT-CO1
full name from nomenclature authority: mitochondrially encoded cytochrome c oxidase I
NCBI GeneID: 4512
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: MT
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has PubMed association: PMID: 7219534; 10508508; 11345519; 11849212; 12140182; 14607829; 14759509; 15036329; 15308583; 15931342; 16002321; 16335786; 16671096; 16740593; 17341490; 17357124; 17559347; 17893145; 18204294; 18251004; 18484665; 18624398; 18705313; 18718066; 19050702; 19147801; 19267350; 19570036; 19758471; 20301403; 20301411; 20301595; 20301607; 20382059; 20936779; 21139048; 21301321; 21389643; 21621438; 21988832; 22252130; 22356826; 22419111; 22927926; 22972377; 22990118; 23030649; 23088713; 23509693; 23712756; 24333447
description: cytochrome c oxidase subunit I
database cross reference: HGNC:7419
database cross reference: MIM:516030

COX2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: COII
alternative term: MTCO2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MT-CO2
full name from nomenclature authority: mitochondrially encoded cytochrome c oxidase II
NCBI GeneID: 4513
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: MT
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has PubMed association: PMID: 7219534; 10194136; 10508508; 11849212; 12031622; 12115729; 12732844; 14607829; 15254227; 15282306; 15308583; 15316498; 15931342; 15965049; 16288875; 17353931; 17500595; 17578348; 17616393; 17619138; 17727817; 17916073; 18224252; 18261751; 18294142; 18314621; 18409190; 18509181; 19050702; 19066432; 19133256; 19295170; 19336478; 19738201; 19758471; 19771519; 19840943; 20034753; 20117988; 20186120; 20301403; 20301411; 20354817; 20401641; 20471030; 20645029; 20934379; 20936779; 20960565; 21069476; 21092633; 21139048; 21301321; 21319273; 21417982; 21424030; 21625016; 21734188; 21782872; 21809666; 21813027; 21840784; 21849808; 21854221; 21857970; 21858104; 21858117; 21890473; 21907277; 21957142; 21984126; 21988832; 22145905; 22170686; 22234093; 22241583; 22252130; 22262461; 22419111; 22487732; 22588264; 22748678; 22870593; 22990118; 23177619; 24061460
description: cytochrome c oxidase subunit II
database cross reference: HGNC:7421
database cross reference: MIM:516040

MTHFR
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MTHFR
full name from nomenclature authority: methylenetetrahydrofolate reductase (NAD(P)H)
NCBI GeneID: 4524
NCBI LocusTag: RP11-56N19.4
gene map location: 1p36.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001666 (EC: IEA); GO_0004489 (EC: TAS); GO_0005829 (EC: TAS); GO_0006520 (EC: TAS, PMID: 7647779); GO_0006766 (EC: TAS); GO_0006767 (EC: TAS); GO_0008015 (EC: TAS, PMID: 7647779); GO_0009086 (EC: IEA); GO_0033274 (EC: IEA); GO_0035999 (EC: IEA); GO_0042493 (EC: IEA); GO_0043005 (EC: IEA); GO_0044281 (EC: TAS); GO_0046500 (EC: IEA); GO_0046655 (EC: TAS); GO_0050660 (EC: IEA); GO_0050661 (EC: IEA); GO_0050667 (EC: IDA); GO_0051593 (EC: IEA); GO_0070555 (EC: IEA); GO_0072341 (EC: IDA)
has PubMed association: PMID: 7647779; 7726158; 7920641; 7951330; 8895734; 8940272; 9545395; 9545406; 9680386; 9719624; 9781030; 10536004; 10679944; 10791559; 11018168; 11022077; 11024398; 11025596; 11048629; 11054348; 11056246; 11058711; 11062308; 11073851; 11074490; 11074524; 11080594; 11084577; 11085290; 11092508; 11094304; 11096266; 11096270; 11098041; 11101473; 11108898; 11118403; 11121176; 11122096; 11124649; 11128675; 11133719; 11142765; 11146461; 11150582; 11155296; 11157318; 11161947; 11168435; 11169021; 11170082; 11170083; 11177206; 11186937; 11197244; 11204578; 11204591; 11228493; 11252530; 11257266; 11257267; 11259808; 11268732; 11274015; 11274424; 11281306; 11282795; 11287760; 11292330; 11295130; 11299748; 11303187; 11303694; 11307798; 11309278; 11310576; 11319193; 11320983; 11323021; 11328206; 11330536; 11336184; 11341749; 11342344; 11342450; 11343335; 11349190; 11359462; 11360806; 11385320; 11386855; 11388660; 11395038; 11397354; 11418485; 11420199; 11423453; 11424140; 11426488; 11427218; 11431185; 11434083; 11436125; 11440783; 11443546; 11451544; 11454529; 11457468; 11464627; 11470464; 11471199; 11480782; 11484165; 11487538; 11494235; 11506076; 11507973; 11509014; 11522740; 11523237; 11531629; 11532106; 11555700; 11558898; 11562338; 11568114; 11569694; 11575217; 11583306; 11584084; 11589919; 11590551; 11592436; 11592445; 11605019; 11669477; 11672761; 11673296; 11680544; 11684547; 11692002; 11692165; 11696022; 11710708; 11711225; 11712321; 11714857; 11718053; 11721146; 11722155; 11734671; 11736945; 11738073; 11738277; 11739968; 11744407; 11744804; 11747974; 11749660; 11751445; 11758232; 11768721; 11776159; 11781870; 11794822; 11801474; 11806787; 11807890; 11807892; 11813127; 11815318; 11821270; 11823591; 11828266; 11843038; 11851723; 11860783; 11860891; 11870335; 11872199; 11872884; 11880124; 11889073; 11904614; 11913566; 11920232; 11925474; 11927833; 11928564; 11929966; 11933257; 11935469; 11938441; 11940092; 11943942; 11947914; 11950428; 11953142; 11961379; 11963567; 11979…
description: methylenetetrahydrofolate reductase (NAD(P)H)

ND1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MTND1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MT-ND1
full name from nomenclature authority: mitochondrially encoded NADH dehydrogenase 1
NCBI GeneID: 4535
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: MT
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has PubMed association: PMID: 6402020; 7219534; 10508508; 11418099; 12100083; 12111463; 12133550; 12618962; 12670626; 12756609; 14580860; 14671420; 14680844; 14759509; 15038995; 15108120; 15110773; 15265369; 15466014; 15505787; 15533721; 15696471; 15860916; 15952130; 15975594; 16060290; 16137960; 16335786; 16414144; 16604388; 16759180; 16784756; 16828917; 16884381; 17035175; 17045122; 17200023; 17429906; 17434142; 17454741; 17562939; 17619138; 17684475; 17717444; 18082471; 18194667; 18239645; 18486613; 18502698; 18504678; 18513491; 18590963; 18679013; 18701018; 18709563; 19050702; 19066432; 19199242; 19199265; 19276764; 19324017; 19487983; 19527690; 19555656; 19758471; 19822128; 20137661; 20176558; 20197120; 20211276; 20301353; 20301403; 20301411; 20643099; 21139048; 21329181; 21625124; 21852384; 21988832; 22079202; 22241583; 22517755; 22653752; 22990118; 23464625; 23530560
description: NADH dehydrogenase, subunit 1 (complex I)
database cross reference: HGNC:7455
database cross reference: MIM:516000

MVK
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LRBP
alternative term: MK
alternative term: MVLK
alternative term: POROK3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MVK
full name from nomenclature authority: mevalonate kinase
NCBI GeneID: 4598
gene map location: 12q24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004496 (EC: IDA, PMID: 1377680); GO_0004496 (EC: IMP, PMID: 10369261); GO_0004496 (EC: TAS); GO_0005524 (EC: IEA); GO_0005777 (EC: IDA, Qualifier: NOT, PMID: 14730012); GO_0005829 (EC: IDA, PMID: 14730012); GO_0005829 (EC: TAS); GO_0006695 (EC: IDA, PMID: 1377680); GO_0006695 (EC: TAS); GO_0008299 (EC: IDA, PMID: 14680974); GO_0019287 (EC: IEA); GO_0042802 (EC: IPI, PMID: 16189514); GO_0044281 (EC: TAS); GO_0050728 (EC: IMP, PMID: 16732551)
has PubMed association: PMID: 1356376; 1377680; 6255462; 8302606; 9146921; 9325256; 9392419; 9464248; 10369261; 10369262; 10401001; 10417275; 11111075; 11313768; 11313769; 12444096; 12477733; 12477932; 12634869; 14680974; 14702039; 14730012; 14749336; 15037710; 15188372; 15489334; 15536479; 16189514; 16234278; 16732551; 16806233; 17213252; 17978300; 18029348; 18193043; 18302342; 18494797; 18512793; 18660489; 18941711; 19060906; 19148283; 19487539; 19605566; 20159775; 20160193; 20194276; 20430392; 20677014; 20686565; 20714348; 20814828; 20864672; 20972250; 21044950; 21124859; 21139048; 21147848; 21430599; 21548022; 22038276; 22159817; 22271696; 22863883; 22939629; 22983302; 23834120; 24064360; 24084495
description: mevalonate kinase
database cross reference: Ensembl:ENSG00000110921
database cross reference: HGNC:7530
database cross reference: HPRD:02015
database cross reference: MIM:251170
database cross reference: Vega:OTTHUMG00000169256

NEDD8
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NEDD-8
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NEDD8
full name from nomenclature authority: neural precursor cell expressed, developmentally down-regulated 8
NCBI GeneID: 4738
gene map location: 14q12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 14
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 15988528); GO_0005634 (EC: IEA); GO_0005829 (EC: TAS); GO_0006357 (EC: IEA); GO_0006464 (EC: TAS, PMID: 9694792); GO_0006508 (EC: TAS, PMID: 9694792); GO_0006511 (EC: TAS, PMID: 9353319); GO_0007179 (EC: TAS); GO_0008104 (EC: IEA); GO_0009653 (EC: TAS, PMID: 9694792); GO_0014070 (EC: IEA); GO_0031625 (EC: IPI, PMID: 15694336); GO_0045116 (EC: IDA, PMID: 10500095); GO_0070062 (EC: IDA)
has PubMed association: PMID: 1378265; 8395831; 8889548; 9353319; 9694792; 9790970; 9857030; 10207026; 10217437; 10318914; 10500095; 10585493; 10587588; 10597293; 10713156; 10772955; 10828074; 11024059; 11027288; 11181995; 11259415; 11585840; 11675391; 11953428; 12215427; 12477932; 12481031; 12504025; 12554766; 12565873; 12646924; 12730221; 12740388; 12759363; 12816948; 14564014; 14673145; 14676825; 14690597; 14702039; 14757770; 15060148; 15107402; 15242646; 15489334; 15567417; 15694336; 15775960; 15988528; 16111684; 16169070; 16177058; 16196087; 16503656; 16620772; 16735510; 16861300; 16877356; 16964240; 16979187; 16980297; 16998474; 17098746; 17119158; 17132228; 17192413; 17206147; 17220875; 17318178; 17332328; 17353931; 17369817; 17438373; 17440617; 17543862; 17546054; 17549501; 17609381; 17660949; 17935801; 18096514; 18173839; 18247557; 18264111; 18274552; 18323857; 18627766; 18652489; 18723677; 18789977; 18805092; 18826954; 18851830; 19245792; 19281774; 19295130; 19328766; 19471022; 19615732; 19713960; 19784069; 20029837; 20101219; 20190741; 20554519; 20596523; 20603103; 20688984; 20847044; 20850415; 21119685; 21139048; 21145461; 21169563; 21193393; 21252943; 21316600; 21399617; 21474709; 21693764; 21765416; 21822215; 21887275; 21890473; 21906983; 21963094; 21987572; 22004789; 22069333; 22081073; 22095636; 22190034; 22268729; 22271254; 22370482; 22388932; 22405651; 22466964; 22474075; 22502714; 22505724; 22537386; 22573887; 22584050; 22612509; 22691497; 22767593; 22836579; 22863883; 22895816; 22939629; 22959436; 23000965; 23001041; 23105008; 23118980; 23175788; 23201271; 23209320; 23246961; 23267066; 23290524; 23300442; 23394999; 23401859; 23539442; 23554956; 23776465; 23812220; 23824602; 23936405; 24019527; 24076655; 24130483
description: neural precursor cell expressed, developmentally down-regulated 8
database cross reference: Ensembl:ENSG00000129559
database cross reference: HGNC:7732
database cross reference: HPRD:04412
database cross reference: MIM:603171
database cross reference: Vega:OTTHUMG00000029325

NEDD9
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CAS-L
alternative term: CAS2
alternative term: CASL
alternative term: CASS2
alternative term: HEF1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NEDD9
full name from nomenclature authority: neural precursor cell expressed, developmentally down-regulated 9
NCBI GeneID: 4739
NCBI LocusTag: RP1-49G10.1
gene map location: 6p25-p24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000922 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11827972); GO_0005634 (EC: IEA); GO_0005737 (EC: TAS, PMID: 9584194); GO_0005794 (EC: IEA); GO_0005819 (EC: TAS, PMID: 9584194); GO_0005925 (EC: IEA); GO_0005938 (EC: IEA); GO_0007010 (EC: NAS, PMID: 11827972); GO_0007067 (EC: IEA); GO_0007155 (EC: IEA); GO_0007165 (EC: TAS, PMID: 8668148); GO_0007229 (EC: NAS, PMID: 11827972); GO_0030027 (EC: IEA); GO_0040008 (EC: IEA); GO_0051017 (EC: NAS, PMID: 11827972)
has PubMed association: PMID: 8668148; 8879209; 9020138; 9162067; 9295052; 9360983; 9366405; 9405482; 9497377; 9498705; 9584194; 9748319; 9820532; 10455189; 10490968; 10502414; 10508479; 10692442; 10808124; 10866674; 11054566; 11118211; 11438665; 11782456; 11827972; 12189134; 12477932; 12517963; 12522270; 12847683; 15051726; 15144186; 15144564; 15231748; 15342556; 15376324; 15489334; 15592516; 16184168; 16344118; 16344560; 16352661; 16394104; 17604723; 17703068; 17908996; 18063669; 18465784; 18579580; 18585997; 18624398; 19103205; 19275884; 19417561; 19539609; 19648964; 20068165; 20379614; 20413850; 20428794; 20430066; 20498643; 20534741; 21059344; 21139048; 21145356; 21317929; 21399483; 21765937; 21829474; 21832049; 21906983; 22061964; 22174851; 22328516; 22447485; 22732573; 22810897; 22869051; 22963925; 23037767; 23074285; 23086683; 23247867; 23355420; 24439227
description: neural precursor cell expressed, developmentally down-regulated 9
database cross reference: Ensembl:ENSG00000111859
database cross reference: HGNC:7733
database cross reference: HPRD:11888
database cross reference: MIM:602265
database cross reference: Vega:OTTHUMG00000014255

NF1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NFNS
alternative term: VRNF
alternative term: WSS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NF1
full name from nomenclature authority: neurofibromin 1
NCBI GeneID: 4763
gene map location: 17q11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: ISS); GO_0001649 (EC: ISS); GO_0001656 (EC: ISS); GO_0001666 (EC: ISS); GO_0001889 (EC: ISS); GO_0001937 (EC: IMP, PMID: 16648142); GO_0001938 (EC: IEA); GO_0001952 (EC: ISS); GO_0001953 (EC: IEA); GO_0005099 (EC: IDA, PMID: 1568247); GO_0005515 (EC: IPI, PMID: 11356864); GO_0005634 (EC: ISS, PMID: 1550670); GO_0005737 (EC: IBA); GO_0005737 (EC: ISS, PMID: 1550670); GO_0006469 (EC: ISS); GO_0007154 (EC: ISS); GO_0007265 (EC: ISS); GO_0007406 (EC: ISS); GO_0007420 (EC: ISS); GO_0007422 (EC: ISS); GO_0007507 (EC: ISS); GO_0007519 (EC: IEA); GO_0008429 (EC: IDA, PMID: 17187824); GO_0008542 (EC: ISS); GO_0008625 (EC: IEA); GO_0014044 (EC: ISS); GO_0014065 (EC: ISS); GO_0016525 (EC: IEA); GO_0021510 (EC: ISS); GO_0021897 (EC: ISS); GO_0021915 (EC: IEA); GO_0021987 (EC: ISS); GO_0022011 (EC: ISS); GO_0030036 (EC: ISS); GO_0030198 (EC: ISS); GO_0030199 (EC: ISS); GO_0030325 (EC: ISS); GO_0030336 (EC: IMP, PMID: 16648142); GO_0030424 (EC: IDA, PMID: 1550670); GO_0030425 (EC: IDA, PMID: 1550670); GO_0031210 (EC: IDA, PMID: 17187824); GO_0031235 (EC: IBA); GO_0032228 (EC: IEA); GO_0032318 (EC: IMP, PMID: 1570015); GO_0032320 (EC: IDA, PMID: 2121371); GO_0032320 (EC: IMP, PMID: 16648142); GO_0032320 (EC: ISS); GO_0035021 (EC: IEA); GO_0042060 (EC: ISS); GO_0042992 (EC: ISS); GO_0043065 (EC: ISS); GO_0043407 (EC: ISS); GO_0043409 (EC: IMP, PMID: 16648142); GO_0043409 (EC: ISS); GO_0043473 (EC: ISS); GO_0043525 (EC: ISS); GO_0043535 (EC: IMP, PMID: 17404841); GO_0045124 (EC: ISS); GO_0045671 (EC: IEA); GO_0045685 (EC: ISS); GO_0045762 (EC: ISS); GO_0045765 (EC: IMP, PMID: 17404841); GO_0046580 (EC: IBA); GO_0046929 (EC: IEA); GO_0048147 (EC: ISS); GO_0048169 (EC: IEA); GO_0048485 (EC: ISS); GO_0048593 (EC: ISS); GO_0048712 (EC: IEA); GO_0048715 (EC: ISS); GO_0048745 (EC: ISS); GO_0048844 (EC: ISS); GO_0048853 (EC: ISS); GO_0050890 (EC: IMP, PMID: 17299016); GO_1902043 (EC: IEA); GO_2001241 (EC: IEA)
has PubMed association: PMID: 1302608; 1329097; 1339276; 1457041; 1550670; 1568247; 1570015; 1662505; 1715669; 1719426; 1745350; 1757093; 1783401; 1923522; 1937470; 2114220; 2116237; 2121370; 2121371; 2125369; 2134734; 2491776; 7519874; 7570581; 7633431; 7633452; 7649559; 7686513; 7774960; 7874161; 7903661; 7904209; 7959746; 7981679; 7981724; 8069310; 8081387; 8176268; 8317503; 8417346; 8544190; 8602361; 8619474; 8628317; 8664912; 8807336; 8825042; 8825634; 8834249; 8836031; 8931693; 9002664; 9003501; 9101300; 9110174; 9150739; 9298829; 9300663; 9529361; 9639526; 9668168; 9706718; 10220149; 10336779; 10553997; 10607834; 10625171; 10712197; 10721668; 10862698; 11140831; 11258625; 11356864; 11704931; 11727199; 11727265; 11735023; 11748857; 11751683; 11754043; 11857752; 11896214; 11896613; 11934389; 12073021; 12077339; 12095621; 12152785; 12191989; 12199909; 12368469; 12387455; 12438263; 12477932; 12483293; 12522551; 12552569; 12566521; 12660952; 12707950; 12730209; 12746402; 12807981; 12872266; 12963615; 13679444; 13680360; 14647436; 14722914; 14988005; 15096131; 15146197; 15146469; 15233998; 15302935; 15342556; 15371411; 15389774; 15520408; 15523626; 15523642; 15583390; 15627836; 15735964; 15767669; 15944227; 15988004; 15999204; 16005615; 16081245; 16083285; 16116616; 16138909; 16169856; 16199547; 16344560; 16374483; 16380919; 16405917; 16467218; 16470740; 16479075; 16565220; 16644864; 16648142; 16741618; 16773574; 16813595; 16830335; 16835260; 16835897; 16908010; 16914719; 16944271; 16944272; 17036045; 17053831; 17096025; 17102080; 17160901; 17187824; 17200120; 17216419; 17295913; 17299016; 17353900; 17404841; 17426081; 17514731; 17563086; 17581973; 17668375; 17726231; 17876295; 17880527; 17914445; 17960768; 17999360; 18021924; 18055911; 18086893; 18172006; 18183042; 18212816; 18214791; 18215124; 18218617; 18316778; 18331998; 18407053; 18484666; 18485440; 18503770; 18511569; 18546366; 18592002; 18802710; 18948576; 19041782; 19048115; 19061981; 19120036; 19142971; 19144660; 19215943; 192207…
description: neurofibromin 1
database cross reference: Ensembl:ENSG00000196712
database cross reference: HGNC:7765
database cross reference: HPRD:01203
database cross reference: MIM:613113
database cross reference: Vega:OTTHUMG00000132871

NFE2L2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NRF2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NFE2L2
full name from nomenclature authority: nuclear factor, erythroid 2-like 2
NCBI GeneID: 4780
gene map location: 2q31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000785 (EC: IEA); GO_0001102 (EC: IPI); GO_0003677 (EC: IDA, PMID: 18554677); GO_0003700 (EC: IEA); GO_0005515 (EC: IPI, PMID: 16888629); GO_0005634 (EC: IDA); GO_0005737 (EC: IDA); GO_0005813 (EC: IDA); GO_0005829 (EC: IDA); GO_0005886 (EC: IDA); GO_0006366 (EC: TAS, PMID: 7937919); GO_0010499 (EC: IDA, PMID: 19424503); GO_0016567 (EC: IDA, PMID: 15983046); GO_0019904 (EC: IPI, PMID: 11256947); GO_0030194 (EC: IEA); GO_0030968 (EC: IEA); GO_0036003 (EC: IMP); GO_0043161 (EC: IDA, PMID: 15983046); GO_0043565 (EC: IEA); GO_0045944 (EC: IMP, PMID: 18202225); GO_0045995 (EC: IEA); GO_0070301 (EC: IMP); GO_0071356 (EC: IMP, PMID: 18202225); GO_0071499 (EC: IMP); GO_1902176 (EC: IMP); GO_2000121 (EC: IEA); GO_2000352 (EC: IMP); GO_2000379 (EC: IEA)
has PubMed association: PMID: 7868116; 7937919; 9150357; 9872330; 9887101; 10419538; 10510468; 10747902; 10930400; 11013233; 11035812; 11256947; 11274184; 11439354; 11683914; 11909699; 12020345; 12084617; 12084707; 12145307; 12198130; 12360409; 12370194; 12435735; 12441344; 12446695; 12477932; 12490281; 12506115; 12556532; 12805554; 12947090; 14517290; 14517554; 14529549; 14565864; 14585973; 14612418; 14985350; 15020583; 15282312; 15358217; 15367669; 15379550; 15475350; 15489334; 15525690; 15572695; 15601839; 15734732; 15870285; 15901726; 15917227; 15917255; 15923610; 15944151; 15964514; 15983046; 15985429; 16000310; 16006525; 16038408; 16092930; 16123320; 16137655; 16177082; 16220540; 16308312; 16314513; 16325767; 16339837; 16344560; 16478829; 16507366; 16545679; 16551616; 16551619; 16716189; 16790425; 16790436; 16857669; 16888629; 16923960; 16950787; 16951152; 17020408; 17065227; 17077087; 17109620; 17143558; 17145701; 17234762; 17259171; 17384144; 17462537; 17562481; 17603223; 17606720; 17609210; 17636022; 17673673; 17726138; 17822364; 17822677; 17875642; 17875699; 17925401; 17982693; 18029348; 18036733; 18038766; 18049112; 18074351; 18097597; 18156441; 18162601; 18172853; 18202225; 18238777; 18240569; 18241676; 18261463; 18316592; 18353146; 18358244; 18372916; 18387606; 18404535; 18413364; 18417180; 18424257; 18434303; 18444152; 18467642; 18537816; 18554677; 18556627; 18566336; 18566994; 18572023; 18585411; 18613373; 18613447; 18622263; 18692501; 18756969; 18757741; 18802114; 18813798; 18829555; 18838122; 18846238; 18981090; 18981988; 19138946; 19158945; 19182219; 19254160; 19272177; 19273602; 19321346; 19345732; 19417020; 19424503; 19478192; 19484125; 19489739; 19538980; 19558496; 19560419; 19573594; 19575798; 19576171; 19608619; 19614772; 19618868; 19643729; 19668370; 19669099; 19671143; 19706542; 19715681; 19720220; 19720622; 19723058; 19751820; 19808663; 19821532; 19822148; 19844581; 19844776; 19889935; 19901266; 19920073; 19934254; 19948975; 19967722; 20011043; 20026169; 20027226;…
description: nuclear factor, erythroid 2-like 2
database cross reference: Ensembl:ENSG00000116044
database cross reference: HGNC:7782
database cross reference: HPRD:02732
database cross reference: MIM:600492
database cross reference: Vega:OTTHUMG00000133620

NFKB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: EBP-1
alternative term: KBF1
alternative term: NF-kB1
alternative term: NF-kappa-B
alternative term: NF-kappaB
alternative term: NFKB-p105
alternative term: NFKB-p50
alternative term: NFkappaB
alternative term: p105
alternative term: p50
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NFKB1
full name from nomenclature authority: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NCBI GeneID: 4790
gene map location: 4q24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IC, PMID: 16938301); GO_0000122 (EC: IMP, PMID: 19881551); GO_0000975 (EC: IDA, PMID: 17426251); GO_0000976 (EC: IDA, PMID: 18718911); GO_0001071 (EC: IDA, PMID: 17426251); GO_0001818 (EC: IEA); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0003690 (EC: IEA); GO_0003700 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10023675); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005739 (EC: IDA); GO_0005829 (EC: TAS); GO_0006366 (EC: TAS, PMID: 1992489); GO_0006915 (EC: IEA); GO_0006954 (EC: TAS, PMID: 1992489); GO_0006979 (EC: IEA); GO_0008134 (EC: IDA, PMID: 18270204); GO_0009617 (EC: IEA); GO_0010744 (EC: IC, PMID: 16938301); GO_0010884 (EC: IC, PMID: 16938301); GO_0010956 (EC: IDA, PMID: 15243130); GO_0010957 (EC: IC, PMID: 15243130); GO_0031072 (EC: IEA); GO_0031293 (EC: TAS); GO_0032269 (EC: IC, PMID: 16938301); GO_0032375 (EC: IC, PMID: 16938301); GO_0032481 (EC: TAS); GO_0033256 (EC: TAS, PMID: 16938301); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035666 (EC: TAS); GO_0038095 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042803 (EC: IEA); GO_0043066 (EC: TAS, PMID: 10811897); GO_0044212 (EC: IDA, PMID: 16938301); GO_0045083 (EC: IEA); GO_0045087 (EC: TAS); GO_0045893 (EC: IDA, PMID: 17426251); GO_0045893 (EC: IMP); GO_0045893 (EC: NAS, PMID: 8096091); GO_0045944 (EC: IEA); GO_0046688 (EC: IEA); GO_0048011 (EC: TAS); GO_0050728 (EC: IEA); GO_0050852 (EC: TAS); GO_0051092 (EC: TAS); GO_0071260 (EC: IEP, PMID: 19593445); GO_0071347 (EC: IEP, PMID: 12958148); GO_0090263 (EC: IMP); GO_1900127 (EC: IDA, PMID: 17324121)
has PubMed association: PMID: 1505523; 1508666; 1518839; 1527859; 1583734; 1612589; 1992489; 2017258; 2050119; 2108863; 2203531; 2234062; 2497520; 7494249; 7651415; 7690421; 7692236; 7694229; 7729429; 7739549; 7742037; 7788295; 7800480; 7823959; 7830764; 7838536; 7859743; 7862168; 7891711; 7933095; 7957556; 8087845; 8096091; 8113688; 8139561; 8151786; 8178481; 8196632; 8207793; 8246997; 8255759; 8290595; 8319912; 8423996; 8428580; 8441377; 8550813; 8615004; 8621941; 8627654; 8628291; 8631829; 8642313; 8649779; 8676466; 8692272; 8709193; 8717528; 8724035; 8746784; 8790371; 8798655; 8814265; 8825636; 8834464; 8870842; 8887676; 8997639; 9094628; 9110146; 9135156; 9218802; 9223487; 9235945; 9250404; 9252186; 9278385; 9315679; 9334723; 9368006; 9468519; 9510190; 9525916; 9529257; 9535861; 9556555; 9560267; 9566873; 9566883; 9572494; 9584180; 9621091; 9722548; 9730685; 9738011; 9792375; 9809067; 9837938; 9865693; 9865694; 9895331; 9950430; 9990852; 10023675; 10075655; 10207088; 10225209; 10235509; 10357819; 10362352; 10384093; 10393859; 10400814; 10426996; 10446807; 10469655; 10480634; 10498867; 10562553; 10580107; 10625680; 10635328; 10644332; 10644726; 10646849; 10671224; 10704334; 10723127; 10775602; 10777532; 10799874; 10811897; 10835356; 10847592; 10856288; 10928981; 10931834; 10969074; 10970863; 11020244; 11036073; 11044099; 11094166; 11158290; 11160671; 11241736; 11278695; 11297557; 11299302; 11313474; 11356851; 11385624; 11418662; 11425860; 11468175; 11511100; 11522182; 11526476; 11579140; 11590148; 11607785; 11696595; 11704662; 11739381; 11756416; 11779220; 11819787; 11827962; 11830587; 11830590; 11833470; 11859566; 11880271; 11931769; 11942414; 11943214; 11953428; 11959143; 11970949; 11971907; 11972054; 11976329; 11980335; 11983170; 12019209; 12021045; 12032828; 12032830; 12040437; 12052823; 12057007; 12058256; 12067898; 12077118; 12077347; 12086956; 12089148; 12091382; 12115625; 12122011; 12133438; 12135603; 12145210; 12150710; 12150997; 12166787; 12167619; 12173051; 12181421; 1219569…
description: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
database cross reference: Ensembl:ENSG00000109320
database cross reference: HGNC:7794
database cross reference: HPRD:01238
database cross reference: MIM:164011
database cross reference: Vega:OTTHUMG00000161080

NGF
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: Beta-NGF
alternative term: HSAN5
alternative term: NGFB
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NGF
full name from nomenclature authority: nerve growth factor (beta polypeptide)
NCBI GeneID: 4803
gene map location: 1p13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000186 (EC: TAS); GO_0005057 (EC: IEA); GO_0005163 (EC: IPI, PMID: 14985763); GO_0005576 (EC: TAS); GO_0005615 (EC: IEA); GO_0005768 (EC: TAS); GO_0005796 (EC: TAS); GO_0006954 (EC: IEA); GO_0007169 (EC: TAS); GO_0007202 (EC: TAS); GO_0007264 (EC: TAS); GO_0007265 (EC: TAS); GO_0007422 (EC: IEA); GO_0007613 (EC: IEA); GO_0008083 (EC: IEA); GO_0008344 (EC: IEA); GO_0008625 (EC: IDA, PMID: 14985763); GO_0009314 (EC: IEA); GO_0009612 (EC: IEA); GO_0010193 (EC: IEA); GO_0010628 (EC: IMP, PMID: 16153003); GO_0019233 (EC: IEA); GO_0031954 (EC: IEA); GO_0032455 (EC: TAS); GO_0032496 (EC: IEA); GO_0035094 (EC: IEA); GO_0042493 (EC: IEA); GO_0043065 (EC: TAS); GO_0043066 (EC: TAS); GO_0043281 (EC: TAS); GO_0043434 (EC: IEA); GO_0043524 (EC: IEA); GO_0045666 (EC: IEA); GO_0045773 (EC: IEA); GO_0045786 (EC: TAS); GO_0046928 (EC: IEA); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0048812 (EC: IDA, PMID: 17724343); GO_0050770 (EC: TAS); GO_0050772 (EC: TAS); GO_0051091 (EC: IEA); GO_0051384 (EC: IEA); GO_0051388 (EC: IEA); GO_0051402 (EC: IEA); GO_0051602 (EC: IEA); GO_0097190 (EC: TAS); GO_0097192 (EC: IEA); GO_2000648 (EC: IEA); GO_2000675 (EC: IEA)
has PubMed association: PMID: 1383421; 1692298; 2025430; 2374737; 2906326; 3871525; 6327169; 6330750; 6648531; 6688123; 7789166; 7806500; 8178451; 8615794; 8808283; 8895847; 9069267; 9182757; 9252186; 9351801; 9575168; 9915784; 10022904; 10322959; 10391209; 10490030; 10629055; 10681572; 10708862; 10712923; 10764727; 10806167; 11157096; 11244088; 11278287; 11487608; 11520933; 11729324; 11738045; 11830582; 11877300; 11935372; 12205295; 12371150; 12376548; 12397373; 12453472; 12477932; 12531456; 12676754; 12676795; 12787561; 12787574; 12900521; 12918708; 12925217; 14587217; 14708938; 14960584; 14970904; 14976160; 14985763; 15128850; 15131306; 15258592; 15361847; 15489334; 15523689; 15544837; 15681836; 15710408; 15721744; 15829579; 16079148; 16153003; 16215275; 16284401; 16313302; 16319926; 16546643; 16630834; 16710414; 16741963; 16786155; 16832412; 16839849; 16919030; 16939974; 16997282; 17081983; 17192954; 17335080; 17487982; 17638883; 17673289; 17703412; 17724343; 17850422; 17854142; 17881264; 17893397; 17905097; 17992191; 18068123; 18179783; 18191449; 18199526; 18203754; 18221326; 18280641; 18300262; 18305571; 18349121; 18420729; 18438945; 18596692; 18635195; 18727839; 18763222; 18780967; 18810245; 18830907; 18922682; 18922683; 19023688; 19038326; 19038341; 19054925; 19063739; 19076929; 19086053; 19120874; 19169037; 19177265; 19183217; 19221293; 19258923; 19264868; 19399531; 19403065; 19475530; 19490633; 19560628; 19598235; 19626992; 19639490; 19649262; 19651702; 19668232; 19695094; 19758188; 19844736; 19874574; 19934806; 19945432; 19950533; 19957796; 19958603; 20119692; 20219210; 20233324; 20360245; 20375017; 20398908; 20503287; 20518854; 20542022; 20680101; 20854189; 20863878; 20881126; 20889312; 20923384; 20978020; 21047631; 21085492; 21153361; 21217078; 21294249; 21321391; 21358750; 21378097; 21387003; 21397006; 21429417; 21596795; 21621608; 21673280; 21693611; 21768088; 21826717; 21893340; 22036954; 22040304; 22105621; 22192858; 22251933; 22272270; 22301435; 22330829; 22411587; 224541…
description: nerve growth factor (beta polypeptide)
database cross reference: Ensembl:ENSG00000134259
database cross reference: HGNC:7808
database cross reference: HPRD:08874
database cross reference: MIM:162030
database cross reference: Vega:OTTHUMG00000011880

NGFR
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD271
alternative term: Gp80-LNGFR
alternative term: TNFRSF16
alternative term: p75(NTR)
alternative term: p75NTR
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NGFR
full name from nomenclature authority: nerve growth factor receptor
NCBI GeneID: 4804
gene map location: 17q21-q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004871 (EC: TAS, PMID: 3022937); GO_0004872 (EC: TAS, PMID: 3022937); GO_0004888 (EC: TAS, PMID: 1846035); GO_0005035 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11756426); GO_0005576 (EC: TAS); GO_0005654 (EC: TAS); GO_0005768 (EC: TAS); GO_0005829 (EC: TAS); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 3022937); GO_0006886 (EC: ISS); GO_0007411 (EC: IEA); GO_0007417 (EC: IEA); GO_0008625 (EC: IEA); GO_0009986 (EC: ISS); GO_0010468 (EC: IEA); GO_0016048 (EC: IEA); GO_0017137 (EC: ISS); GO_0021675 (EC: IEA); GO_0031069 (EC: IEA); GO_0031293 (EC: TAS); GO_0031625 (EC: IPI, PMID: 11279055); GO_0040037 (EC: IEA); GO_0042488 (EC: IEA); GO_0042593 (EC: ISS); GO_0043065 (EC: TAS); GO_0043066 (EC: TAS); GO_0043281 (EC: TAS); GO_0045786 (EC: TAS); GO_0048011 (EC: TAS); GO_0048146 (EC: IEA); GO_0048406 (EC: IEA); GO_0050770 (EC: TAS); GO_0050771 (EC: TAS); GO_0050772 (EC: TAS); GO_0051799 (EC: IEA); GO_0097190 (EC: TAS); GO_2001235 (EC: IEA); GO_2001273 (EC: ISS)
has PubMed association: PMID: 1281863; 1316918; 1324502; 1846035; 2850481; 2989274; 3006050; 3008331; 3020711; 3022937; 7541035; 7541633; 7903404; 8407983; 8614797; 8627329; 8889548; 9252186; 9368064; 9575168; 9626059; 9665396; 9867838; 9915784; 9927421; 10022904; 10485890; 10514511; 10544233; 10545116; 10595511; 10764727; 10985348; 11150334; 11201742; 11244088; 11278287; 11279055; 11487608; 11729324; 11756426; 11756498; 11818506; 11830582; 11927634; 12011108; 12034707; 12107411; 12163480; 12371150; 12376548; 12414813; 12422217; 12426574; 12460612; 12477932; 12604596; 12672029; 12676795; 12682012; 12692556; 12716928; 12768436; 12787561; 12789270; 12821676; 12821936; 12843241; 12913006; 12951563; 12963025; 14593116; 14689592; 14960584; 14966521; 14985763; 15015775; 15128850; 15131306; 15165637; 15258592; 15274039; 15310753; 15337528; 15378608; 15489334; 15523689; 15681836; 15694321; 15701642; 15721744; 15784962; 15953414; 16099913; 16113645; 16215275; 16215672; 16344560; 16460673; 16498402; 16555252; 16586073; 16630834; 16704535; 16826429; 16893414; 16951226; 16997282; 17110619; 17196528; 17287525; 17335080; 17349981; 17355907; 17357149; 17492429; 17510309; 17531524; 17582777; 17603629; 17619016; 17696644; 17703412; 17850422; 17947706; 17971243; 17986144; 18029348; 18036543; 18081157; 18196575; 18203754; 18221326; 18305571; 18319596; 18394312; 18428117; 18462868; 18470533; 18477014; 18540978; 18566344; 18780967; 19041213; 19066726; 19072833; 19086053; 19131967; 19169037; 19177265; 19225519; 19240061; 19258923; 19301169; 19386345; 19490633; 19598235; 19615036; 19758188; 19918800; 19945432; 20022966; 20219210; 20237496; 20351714; 20503287; 20530577; 20549701; 20596026; 20659559; 20680101; 20854189; 20943663; 21097678; 21123453; 21142793; 21151024; 21178583; 21307265; 21343882; 21393506; 21397006; 21418516; 21503896; 21807134; 21814043; 21851375; 21900206; 21938001; 21982860; 22040987; 22068036; 22138126; 22161836; 22170235; 22207443; 22236693; 22343487; 22419851; 22454143; 22558167; 22566094;…
description: nerve growth factor receptor
database cross reference: Ensembl:ENSG00000064300
database cross reference: HGNC:7809
database cross reference: HPRD:01197
database cross reference: MIM:162010
database cross reference: Vega:OTTHUMG00000161495

NOS1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IHPS1
alternative term: N-NOS
alternative term: NC-NOS
alternative term: NOS
alternative term: bNOS
alternative term: nNOS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NOS1
full name from nomenclature authority: nitric oxide synthase 1 (neuronal)
NCBI GeneID: 4842
gene map location: 12q24.22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001666 (EC: IEP, PMID: 16276418); GO_0001917 (EC: ISS, PMID: 17027776); GO_0003958 (EC: IBA); GO_0004517 (EC: IBA); GO_0004517 (EC: ISS); GO_0005506 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11149895); GO_0005516 (EC: IEA); GO_0005737 (EC: TAS, PMID: 17892502); GO_0005829 (EC: TAS); GO_0005856 (EC: ISS, PMID: 7545544); GO_0006527 (EC: IC, PMID: 7545544); GO_0006809 (EC: IBA); GO_0006809 (EC: ISS, PMID: 7545544); GO_0006941 (EC: IEA); GO_0007263 (EC: IBA); GO_0007520 (EC: TAS, PMID: 7545544); GO_0007596 (EC: TAS); GO_0009408 (EC: IDA, PMID: 18048451); GO_0010181 (EC: ISS); GO_0010523 (EC: TAS, PMID: 17568574); GO_0016491 (EC: IBA); GO_0016529 (EC: IDA, PMID: 9892689); GO_0017080 (EC: ISS); GO_0018119 (EC: ISS); GO_0020037 (EC: ISS); GO_0031284 (EC: IBA); GO_0033555 (EC: IMP, PMID: 18391107); GO_0034617 (EC: NAS, PMID: 7488039); GO_0034618 (EC: TAS, PMID: 17029414); GO_0035066 (EC: IEA); GO_0042136 (EC: TAS, PMID: 7545544); GO_0042383 (EC: IDA, PMID: 7545544); GO_0042738 (EC: IEA); GO_0043197 (EC: IEA); GO_0043234 (EC: ISS); GO_0043267 (EC: IEA); GO_0044325 (EC: ISS); GO_0045202 (EC: IEA); GO_0045776 (EC: IBA); GO_0045909 (EC: IDA, PMID: 18048451); GO_0045909 (EC: IMP, PMID: 18391107); GO_0045944 (EC: IEA); GO_0046870 (EC: ISS); GO_0048471 (EC: ISS, PMID: 17027776); GO_0050660 (EC: ISS); GO_0050661 (EC: ISS); GO_0051346 (EC: IEA); GO_0051612 (EC: IEA); GO_0051701 (EC: TAS); GO_0055117 (EC: TAS, PMID: 9892689); GO_0071363 (EC: IEA); GO_0090382 (EC: TAS); GO_0097110 (EC: ISS); GO_1902307 (EC: ISS)
has PubMed association: PMID: 1375933; 1379716; 1385308; 7488039; 7515942; 7521167; 7528745; 7545544; 7558036; 7561697; 7678401; 7682706; 7685260; 8581564; 8625413; 8864115; 8879752; 8922396; 8943206; 9111048; 9353265; 9412493; 9459447; 9791007; 9808772; 9837926; 9870939; 9880522; 9892689; 10068656; 10187848; 10203575; 10221915; 10400690; 10443886; 10488080; 10518591; 10681501; 10751385; 10824095; 10874031; 11043403; 11052978; 11086993; 11112111; 11149895; 11284722; 11404282; 11511520; 11525805; 11546971; 11590170; 11591728; 11668616; 11747091; 11786430; 11849436; 11849441; 11867766; 11890749; 11960979; 12081486; 12081996; 12140778; 12184796; 12210288; 12237228; 12403769; 12421162; 12445599; 12477932; 12485841; 12490535; 12531780; 12572877; 12630910; 12646269; 12686399; 12715886; 12759556; 12777376; 12782337; 12787407; 12802542; 12816735; 12908999; 12911502; 12947326; 14602725; 14615895; 14623375; 14711010; 14752097; 14757827; 14759629; 14760158; 14980078; 15033959; 15044250; 15075442; 15080837; 15088155; 15094474; 15105416; 15119548; 15161750; 15167446; 15180967; 15191553; 15194886; 15242984; 15251453; 15287858; 15466472; 15548660; 15699372; 15765269; 15856945; 16191396; 16229016; 16238787; 16276418; 16380905; 16389274; 16413742; 16569214; 16690617; 16780147; 16848803; 16950998; 17027776; 17029414; 17161399; 17161551; 17174475; 17328085; 17351066; 17351927; 17359361; 17360663; 17365914; 17418914; 17448763; 17459909; 17466601; 17492662; 17536218; 17568574; 17579350; 17601350; 17660395; 17690329; 17703412; 17892502; 17924542; 17970747; 18024942; 18042235; 18048451; 18058820; 18086269; 18257968; 18391107; 18465682; 18541744; 18544180; 18563708; 18591664; 18606955; 18614941; 18671896; 18675932; 18720901; 18784277; 18821565; 18953332; 18971208; 18977241; 19086053; 19087148; 19089323; 19103196; 19124687; 19161160; 19247692; 19258923; 19326438; 19328558; 19371282; 19372141; 19415232; 19423521; 19423540; 19433760; 19457105; 19505917; 19513863; 19552920; 19603529; 19642705; 19657898; 19687346; 197…
description: nitric oxide synthase 1 (neuronal)
database cross reference: Ensembl:ENSG00000089250
database cross reference: HGNC:7872
database cross reference: HPRD:01226
database cross reference: MIM:163731
database cross reference: Vega:OTTHUMG00000137376

NOS2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HEP-NOS
alternative term: INOS
alternative term: NOS
alternative term: NOS2A
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NOS2
full name from nomenclature authority: nitric oxide synthase 2, inducible
NCBI GeneID: 4843
gene map location: 17q11.2-q12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001666 (EC: IEA); GO_0001912 (EC: TAS, PMID: 10450191); GO_0002227 (EC: NAS, PMID: 18390757); GO_0003958 (EC: IBA); GO_0004517 (EC: IDA, PMID: 7504305); GO_0005102 (EC: IPI); GO_0005506 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12855682); GO_0005516 (EC: IEA); GO_0005622 (EC: IDA, PMID: 7544003); GO_0005634 (EC: ISS); GO_0005737 (EC: IDA, PMID: 12085352); GO_0005777 (EC: IDA, PMID: 12085352); GO_0005829 (EC: IMP, PMID: 7504305); GO_0005829 (EC: TAS); GO_0006527 (EC: IDA, PMID: 7504305); GO_0006801 (EC: ISS); GO_0006809 (EC: IDA, PMID: 7504305); GO_0006954 (EC: IBA); GO_0007263 (EC: IBA); GO_0007596 (EC: TAS); GO_0009617 (EC: NAS, PMID: 12085352); GO_0010181 (EC: ISS); GO_0010629 (EC: IGI, PMID: 12085352); GO_0018119 (EC: ISS); GO_0020037 (EC: ISS); GO_0030863 (EC: IEA); GO_0031284 (EC: IBA); GO_0034617 (EC: ISS); GO_0034618 (EC: ISS); GO_0042127 (EC: IEA); GO_0042177 (EC: IEA); GO_0042742 (EC: IMP, PMID: 9284131); GO_0042742 (EC: ISS); GO_0042803 (EC: ISS); GO_0043457 (EC: TAS, PMID: 10450191); GO_0045776 (EC: IBA); GO_0045909 (EC: IBA); GO_0048471 (EC: IEA); GO_0050660 (EC: ISS); GO_0050661 (EC: TAS, PMID: 7504305); GO_0050796 (EC: IMP, PMID: 8383325); GO_0050829 (EC: NAS, PMID: 18390757); GO_0051701 (EC: TAS); GO_0051712 (EC: IMP, PMID: 7544003); GO_0071222 (EC: IEA); GO_0071346 (EC: IEA); GO_0090382 (EC: TAS)
has PubMed association: PMID: 7504305; 7509810; 7514565; 7522054; 7524082; 7526541; 7528017; 7528106; 7531613; 7531687; 7532248; 7544003; 7544004; 7558036; 7561697; 7682706; 7692964; 8383325; 8645258; 8653828; 8699932; 8760410; 8943206; 9160867; 9239710; 9284131; 9870939; 9916929; 10068656; 10074942; 10203575; 10393859; 10409685; 10443886; 10446807; 10450191; 10842192; 11050162; 11114180; 11294696; 11297817; 11397889; 11422783; 11424980; 11443559; 11457725; 11525805; 11579140; 11692109; 11761338; 11783017; 11849384; 11880293; 11907646; 11956620; 11978184; 11985259; 11985871; 12060397; 12080081; 12081717; 12085352; 12097137; 12117977; 12119468; 12125143; 12135432; 12140750; 12167619; 12174362; 12195390; 12221289; 12223351; 12237122; 12243747; 12296866; 12374680; 12381793; 12399227; 12406306; 12421162; 12431203; 12433515; 12445411; 12445599; 12452003; 12459168; 12462194; 12477932; 12482371; 12486325; 12489192; 12490535; 12508391; 12509623; 12533668; 12552317; 12578118; 12590140; 12598314; 12601489; 12607534; 12631094; 12641410; 12687343; 12690222; 12709136; 12732844; 12736741; 12768436; 12777376; 12788789; 12799216; 12800233; 12816735; 12824008; 12828935; 12855682; 12875991; 12919943; 12937869; 12948935; 12958187; 12960352; 14551604; 14574328; 14614131; 14614209; 14616549; 14623011; 14634838; 14636285; 14638407; 14677189; 14715665; 14740870; 14764920; 14981908; 14985675; 14991947; 15026539; 15044505; 15100320; 15107292; 15112337; 15115662; 15174013; 15180967; 15205363; 15222024; 15222037; 15226517; 15242984; 15259072; 15271950; 15275951; 15284293; 15285794; 15349722; 15482399; 15482484; 15484300; 15492785; 15494775; 15532709; 15583989; 15601772; 15609395; 15617837; 15631944; 15631946; 15642965; 15654505; 15683721; 15695237; 15754329; 15784171; 15838334; 15849807; 15856071; 15856945; 15922861; 15940772; 16020977; 16105645; 16116474; 16126846; 16136006; 16191398; 16195370; 16211247; 16229182; 16243805; 16260491; 16265698; 16282997; 16288199; 16290060; 16311916; 16326029; 16335796; 16352737; 16…
description: nitric oxide synthase 2, inducible
database cross reference: Ensembl:ENSG00000007171
database cross reference: HGNC:7873
database cross reference: HPRD:01225
database cross reference: MIM:163730
database cross reference: Vega:OTTHUMG00000132445

NOTCH1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: TAN1
alternative term: hN1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NOTCH1
full name from nomenclature authority: notch 1
NCBI GeneID: 4851
gene map location: 9q34.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: ISS); GO_0000139 (EC: TAS); GO_0001047 (EC: ISS); GO_0001190 (EC: ISS); GO_0001701 (EC: IEA); GO_0001708 (EC: IEA); GO_0001837 (EC: ISS); GO_0001889 (EC: IEA); GO_0001947 (EC: ISS); GO_0002040 (EC: IEA); GO_0002193 (EC: IDA, PMID: 16510869); GO_0002437 (EC: IEA); GO_0003157 (EC: ISS); GO_0003160 (EC: ISS); GO_0003162 (EC: IEA); GO_0003169 (EC: ISS); GO_0003180 (EC: IMP, PMID: 16025100); GO_0003181 (EC: ISS); GO_0003184 (EC: IMP, PMID: 16025100); GO_0003192 (EC: IMP, PMID: 16025100); GO_0003198 (EC: ISS); GO_0003203 (EC: ISS); GO_0003207 (EC: ISS); GO_0003208 (EC: ISS); GO_0003209 (EC: ISS); GO_0003213 (EC: ISS); GO_0003214 (EC: ISS); GO_0003219 (EC: IEA); GO_0003222 (EC: ISS); GO_0003241 (EC: ISS); GO_0003256 (EC: ISS); GO_0003270 (EC: IEA); GO_0003273 (EC: ISS); GO_0003344 (EC: ISS); GO_0003700 (EC: IEA); GO_0004857 (EC: ISS); GO_0004872 (EC: IEA); GO_0005509 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10713164); GO_0005576 (EC: TAS); GO_0005634 (EC: ISS); GO_0005634 (EC: TAS, PMID: 10713164); GO_0005654 (EC: TAS); GO_0005789 (EC: TAS); GO_0005829 (EC: TAS); GO_0005886 (EC: TAS); GO_0006355 (EC: TAS, PMID: 10713164); GO_0006367 (EC: TAS); GO_0006955 (EC: NAS, PMID: 1831692); GO_0006959 (EC: IEA); GO_0007219 (EC: IMP, PMID: 19682396); GO_0007219 (EC: TAS, PMID: 10713164); GO_0007220 (EC: TAS); GO_0007221 (EC: ISS); GO_0007368 (EC: ISS); GO_0007386 (EC: IEA); GO_0007409 (EC: IEA); GO_0007440 (EC: IEA); GO_0007492 (EC: IEA); GO_0007507 (EC: IMP); GO_0008284 (EC: IDA, PMID: 17849174); GO_0008284 (EC: IMP); GO_0008285 (EC: IDA); GO_0009912 (EC: IEA); GO_0009986 (EC: IEA); GO_0010001 (EC: IEA); GO_0010467 (EC: TAS); GO_0010718 (EC: IMP, PMID: 17984306); GO_0010812 (EC: IDA, PMID: 16501043); GO_0010832 (EC: ISS); GO_0014031 (EC: ISS); GO_0014807 (EC: IEA); GO_0016021 (EC: IEA); GO_0019899 (EC: ISS); GO_0021915 (EC: IEA); GO_0030216 (EC: IEA); GO_0030279 (EC: ISS); GO_0030324 (EC: IEA); GO_0030335 (EC: ISS); GO_0030513 (EC: ISS); GO_0030514 (EC: ISS); GO_0030900 …
has PubMed association: PMID: 1764995; 1831692; 7512837; 7698746; 8642313; 8749394; 8755477; 9111040; 9169836; 9244302; 9590294; 9620803; 9653148; 10077672; 10079256; 10082551; 10206645; 10221902; 10637481; 10669757; 10713164; 10747963; 10837024; 10882063; 10935626; 10940313; 11006133; 11101851; 11112321; 11226752; 11390662; 11404076; 11418662; 11425854; 11511084; 11518718; 11564735; 11585921; 11604490; 11604511; 11700865; 11739188; 11777909; 11827460; 11836628; 11848684; 11940670; 11964309; 11978185; 11997524; 12048239; 12050162; 12065598; 12123574; 12145413; 12208848; 12357247; 12370315; 12370358; 12374741; 12477932; 12482957; 12486116; 12496471; 12509463; 12527910; 12532332; 12644465; 12682059; 12697902; 12768030; 12781689; 12795601; 12829602; 12913000; 12960155; 14567914; 14583609; 14602722; 14638857; 14645224; 14670925; 14678992; 14726396; 14756819; 14762442; 14996707; 15044485; 15058751; 15146197; 15213460; 15240571; 15280477; 15448134; 15472075; 15485896; 15492044; 15492845; 15546612; 15563463; 15563588; 15576031; 15650752; 15756589; 15774577; 15781650; 15817159; 15824732; 15904468; 15976178; 15987768; 16011479; 16025100; 16079893; 16096376; 16136053; 16160079; 16169070; 16179393; 16239965; 16287852; 16298817; 16317090; 16319921; 16322473; 16344560; 16365048; 16378632; 16434391; 16449526; 16501043; 16507111; 16510869; 16530044; 16536739; 16608439; 16618808; 16622004; 16651424; 16688224; 16707600; 16713569; 16729972; 16738328; 16785210; 16822655; 16871543; 16880534; 16887975; 16951331; 16990763; 17008890; 17028268; 17046738; 17090547; 17107915; 17114293; 17186020; 17252014; 17284587; 17301032; 17309564; 17316355; 17317671; 17318174; 17344417; 17353266; 17368826; 17392684; 17404512; 17425682; 17434929; 17497677; 17513037; 17526737; 17560996; 17573339; 17575125; 17604336; 17636029; 17646408; 17646409; 17652726; 17662764; 17664272; 17671232; 17716607; 17804701; 17822320; 17849174; 17851046; 17873882; 17874453; 17901244; 17920003; 17922104; 17927876; 17948123; 17967789; 17980397; 1798430…
description: notch 1
database cross reference: Ensembl:ENSG00000148400
database cross reference: HGNC:7881
database cross reference: HPRD:01827
database cross reference: MIM:190198
database cross reference: Vega:OTTHUMG00000020935

NPY
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PYY4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NPY
full name from nomenclature authority: neuropeptide Y
NCBI GeneID: 4852
gene map location: 7p15.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001664 (EC: IEA); GO_0004930 (EC: TAS, PMID: 1321422); GO_0005102 (EC: TAS, PMID: 10698177); GO_0005184 (EC: TAS, PMID: 2427515); GO_0005246 (EC: TAS, PMID: 8132547); GO_0005576 (EC: TAS); GO_0005615 (EC: ISS); GO_0005623 (EC: TAS, PMID: 2444979); GO_0006816 (EC: TAS, PMID: 8132547); GO_0006928 (EC: TAS, PMID: 10488139); GO_0007187 (EC: TAS, PMID: 8132547); GO_0007218 (EC: IEA); GO_0007268 (EC: TAS, PMID: 10557353); GO_0007586 (EC: NAS, PMID: 8421707); GO_0007610 (EC: TAS, PMID: 9845072); GO_0007631 (EC: TAS, PMID: 10698177); GO_0008015 (EC: NAS, PMID: 8421707); GO_0008217 (EC: IEA); GO_0008283 (EC: TAS, PMID: 10488139); GO_0008343 (EC: ISS); GO_0021954 (EC: IEP); GO_0021987 (EC: IEP, PMID: 9067840); GO_0031175 (EC: IEP); GO_0032100 (EC: ISS)
has PubMed association: PMID: 1321422; 1425680; 2427515; 2444979; 3753985; 3839058; 6589611; 7493937; 7559383; 7782078; 8132547; 8421707; 9001438; 9008359; 9067840; 9845072; 10488139; 10557353; 10561544; 10698177; 10770181; 11196643; 11278902; 11325787; 11410744; 11422604; 11689216; 11696660; 11814620; 11884208; 11914038; 11932939; 12007534; 12015205; 12034130; 12081635; 12106685; 12187394; 12187924; 12209475; 12215082; 12454738; 12477932; 12479530; 12544000; 12609745; 12646110; 12663466; 12689610; 12690205; 12759898; 12782203; 12818415; 12843176; 12853948; 12875921; 12878188; 12932169; 14628185; 14747236; 14751436; 15126561; 15165988; 15201542; 15336593; 15364898; 15485137; 15489334; 15597110; 15604093; 15625769; 15680469; 15736042; 15759545; 15797951; 15847953; 15850450; 15894681; 15897713; 15926114; 15959845; 16135994; 16136022; 16339211; 16382997; 16382999; 16383000; 16383001; 16383009; 16383010; 16390370; 16459651; 16500360; 16568137; 16785149; 16912140; 17066479; 17154253; 17187020; 17268419; 17305733; 17325259; 17366345; 17516289; 17525122; 17554476; 17695723; 17702963; 17948870; 17984244; 18031993; 18037100; 18043699; 18054939; 18055304; 18211417; 18241322; 18257117; 18279562; 18385673; 18420205; 18423883; 18461271; 18499283; 18577758; 18636124; 18641693; 18715275; 18815063; 18828811; 18974842; 18996102; 19056482; 19058789; 19086053; 19119412; 19150389; 19240061; 19245788; 19264362; 19289742; 19309436; 19367093; 19404163; 19423065; 19491387; 19566775; 19587357; 19619519; 19620246; 19699258; 19804960; 19846279; 19854625; 19865784; 19874574; 19913121; 19913525; 19942238; 20033074; 20037921; 20138117; 20164781; 20173430; 20180986; 20308990; 20351714; 20435026; 20452482; 20453000; 20459474; 20468064; 20531438; 20543711; 20554694; 20602615; 20628086; 20648632; 20673868; 20675276; 20676138; 20691708; 20734064; 20823688; 20832114; 20945961; 21041608; 21047193; 21145602; 21190576; 21273004; 21303710; 21346312; 21396710; 21426768; 21468772; 21626172; 21640760; 21746772; 21796371; 21849543; …
description: neuropeptide Y
database cross reference: Ensembl:ENSG00000122585
database cross reference: HGNC:7955
database cross reference: HPRD:01214
database cross reference: MIM:162640
database cross reference: Vega:OTTHUMG00000022973

NTF3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HDNF
alternative term: NGF-2
alternative term: NGF2
alternative term: NT-3
alternative term: NT3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NTF3
full name from nomenclature authority: neurotrophin 3
NCBI GeneID: 4908
gene map location: 12p13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: IDA); GO_0002092 (EC: IDA); GO_0005102 (EC: TAS, PMID: 2236018); GO_0005165 (EC: IEA); GO_0005576 (EC: IEA); GO_0007165 (EC: TAS, PMID: 2236018); GO_0007169 (EC: IDA); GO_0007267 (EC: TAS, PMID: 2236018); GO_0007274 (EC: IEA); GO_0007399 (EC: TAS, PMID: 1542658); GO_0007403 (EC: IEA); GO_0007411 (EC: IEA); GO_0007420 (EC: IEA); GO_0007422 (EC: IEA); GO_0008083 (EC: IDA); GO_0008284 (EC: IDA); GO_0008544 (EC: IEA); GO_0016023 (EC: IEA); GO_0021675 (EC: IEA); GO_0030335 (EC: IDA); GO_0032148 (EC: IDA); GO_0032856 (EC: IDA); GO_0033138 (EC: IDA); GO_0042056 (EC: IDA); GO_0042490 (EC: IEA); GO_0042552 (EC: IEA); GO_0043524 (EC: IEA); GO_0045687 (EC: IEA); GO_0045944 (EC: IEA); GO_0048406 (EC: IEA); GO_0048484 (EC: IEA); GO_0050731 (EC: IDA); GO_0050732 (EC: IDA); GO_0050804 (EC: IEA); GO_0050918 (EC: IDA); GO_0050930 (EC: IDA); GO_0051145 (EC: IEA); GO_2000251 (EC: IDA)
has PubMed association: PMID: 1542658; 1645620; 1889806; 1889807; 2025430; 2236018; 2344409; 2365067; 7514502; 7703225; 7733919; 7991545; 8621424; 8819011; 8841198; 8925252; 9488719; 9756741; 9973222; 11580868; 11877300; 11920853; 12107412; 12397373; 12477932; 12598727; 12710933; 12900521; 15146197; 15365216; 15474906; 15489334; 15544837; 15589528; 15770067; 15843147; 16441896; 16786155; 17112518; 17192954; 17207965; 17234344; 17698064; 18069415; 18179783; 18203754; 18305571; 18313696; 18336001; 18428117; 18438927; 18438945; 18596692; 19086053; 19357934; 19369542; 19453261; 19598235; 19680743; 20060128; 20160348; 20219210; 20360537; 20379614; 20576502; 20597688; 21085492; 21261755; 21392742; 21698095; 21720807; 21787840; 21996274; 22036954; 22158057; 22192858; 22454143; 22459634; 23001042; 23027130; 23038618; 23075484; 23149719; 23185507; 23426664; 23522042; 23869086
description: neurotrophin 3
database cross reference: Ensembl:ENSG00000185652
database cross reference: HGNC:8023
database cross reference: HPRD:01219
database cross reference: MIM:162660
database cross reference: Vega:OTTHUMG00000168649

NTF4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GLC10
alternative term: GLC1O
alternative term: NT-4
alternative term: NT-4/5
alternative term: NT-5
alternative term: NT4
alternative term: NT5
alternative term: NTF5
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NTF4
full name from nomenclature authority: neurotrophin 4
NCBI GeneID: 4909
gene map location: 19q13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005576 (EC: ISS, PMID: 10908605); GO_0005788 (EC: ISS, PMID: 925010); GO_0007402 (EC: ISS, PMID: 10681461); GO_0007616 (EC: ISS, PMID: 10869436); GO_0008052 (EC: ISS, PMID: 10479455); GO_0008083 (EC: IEA); GO_0008344 (EC: ISS, PMID: 10681461); GO_0008544 (EC: ISS, PMID: 9973328); GO_0042490 (EC: IEA)
has PubMed association: PMID: 925010; 1313578; 1496419; 1742028; 7541633; 7703225; 8061955; 8241191; 8873083; 9519408; 9973328; 10388563; 10479455; 10490030; 10631974; 10681461; 10869436; 10908605; 11263982; 11738045; 11855816; 12397373; 12477932; 12900521; 15258592; 15489334; 15987945; 16316409; 16648150; 16648236; 18179783; 18203754; 18305571; 18980528; 19081579; 19086053; 19598235; 19765683; 20175187; 20215012; 20219210; 20447632; 20463313; 20806036; 21330466; 21350004; 21988832; 22036954; 22192858; 22815630; 23869086
description: neurotrophin 4
database cross reference: Ensembl:ENSG00000225950
database cross reference: HGNC:8024
database cross reference: HPRD:01220
database cross reference: MIM:162662

NTRK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MTC
alternative term: TRK
alternative term: TRK1
alternative term: TRKA
alternative term: Trk-A
alternative term: p140-TrkA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NTRK1
full name from nomenclature authority: neurotrophic tyrosine kinase, receptor, type 1
NCBI GeneID: 4914
gene map location: 1q21-q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000186 (EC: TAS); GO_0004714 (EC: IDA, PMID: 15488758); GO_0005166 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12237455); GO_0005524 (EC: IEA); GO_0005768 (EC: TAS); GO_0005769 (EC: ISS); GO_0005770 (EC: ISS); GO_0005886 (EC: ISS); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 15488758); GO_0006468 (EC: IDA, PMID: 15488758); GO_0007169 (EC: TAS); GO_0007190 (EC: TAS); GO_0007202 (EC: TAS); GO_0007264 (EC: TAS); GO_0007265 (EC: TAS); GO_0007411 (EC: IEA); GO_0007568 (EC: IEA); GO_0007611 (EC: IEA); GO_0008285 (EC: IDA, PMID: 15488758); GO_0008285 (EC: IDA, Qualifier: NOT, PMID: 15488758); GO_0009314 (EC: IEA); GO_0009986 (EC: IEA); GO_0010465 (EC: IDA, PMID: 15488758); GO_0010623 (EC: ISS); GO_0010976 (EC: IDA, PMID: 15488758); GO_0010976 (EC: IDA, Qualifier: NOT, PMID: 15488758); GO_0014823 (EC: IEA); GO_0018108 (EC: IDA, PMID: 15488758); GO_0021553 (EC: IEA); GO_0030183 (EC: IEA); GO_0030424 (EC: IEA); GO_0030425 (EC: IEA); GO_0031410 (EC: IEA); GO_0031667 (EC: IEA); GO_0031901 (EC: IEA); GO_0031902 (EC: IEA); GO_0032320 (EC: IDA, PMID: 15488758); GO_0032320 (EC: IDA, Qualifier: NOT, PMID: 15488758); GO_0042490 (EC: IEA); GO_0042493 (EC: IEA); GO_0042803 (EC: IDA, PMID: 17196528); GO_0043025 (EC: IEA); GO_0043068 (EC: ISS); GO_0043121 (EC: TAS, PMID: 9290260); GO_0043234 (EC: ISS); GO_0043235 (EC: IDA); GO_0043524 (EC: ISS); GO_0045471 (EC: IEA); GO_0045766 (EC: IDA, PMID: 15488758); GO_0046579 (EC: IDA, PMID: 15488758); GO_0046579 (EC: IDA, Qualifier: NOT, PMID: 15488758); GO_0046777 (EC: IDA, PMID: 15488758); GO_0046875 (EC: IEA); GO_0048011 (EC: IDA, PMID: 15488758); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0048406 (EC: IDA, PMID: 15488758); GO_0048406 (EC: IDA, Qualifier: NOT, PMID: 15488758); GO_0048485 (EC: ISS); GO_0048678 (EC: IEA); GO_0050965 (EC: IEA); GO_0050966 (EC: IEA); GO_0051092 (EC: IDA, PMID: 15488758); GO_0051599 (EC: IEA); GO_0051602 (EC: IEA); GO_0051968 (EC: IEA); GO_0060009 (EC: IEA); GO_0060385 (EC: ISS); GO_0070374 (EC: IDA, PMID: 15…
has PubMed association: PMID: 1463607; 1532241; 1656363; 1695324; 1706478; 1715690; 1849459; 1850821; 2869410; 2927393; 2966065; 7509449; 7510697; 7541035; 7542991; 7565764; 7601468; 7657647; 7806500; 7823156; 8155326; 8183561; 8226808; 8325889; 8384556; 8524391; 8577769; 8610109; 8621424; 8696348; 8889548; 8943228; 8957089; 9069267; 9099755; 9182757; 9282923; 9290260; 9341772; 9507002; 9856458; 9867838; 9927421; 10090906; 10092678; 10103137; 10233776; 10329710; 10330344; 10388563; 10391209; 10443680; 10490030; 10567924; 10629055; 10679771; 10708759; 10712923; 10747026; 10748052; 10861667; 10982191; 11071380; 11147812; 11150334; 11157096; 11159935; 11244088; 11251075; 11310631; 11466412; 11520933; 11668614; 11705863; 11729324; 11733534; 11738045; 11850535; 11859925; 12006576; 12102460; 12150951; 12208732; 12210794; 12237455; 12406349; 12446789; 12471037; 12477932; 12536040; 14642435; 14691455; 14985763; 14988025; 15024033; 15159601; 15167895; 15273715; 15362372; 15488758; 15489334; 15513915; 15523689; 15637590; 15753086; 15870692; 15950763; 15961390; 16091303; 16113645; 16138253; 16181609; 16246731; 16275928; 16284401; 16373086; 16483615; 16546643; 16586073; 16701206; 16704535; 16710414; 16786155; 16805430; 16860569; 16862449; 16919030; 16935282; 16939974; 16996570; 17143529; 17196528; 17267689; 17447019; 17531524; 17548467; 17617666; 17619016; 17635673; 17667845; 17671718; 17673289; 17850422; 17971243; 18005706; 18072090; 18077166; 18174161; 18203754; 18221326; 18270328; 18305571; 18319596; 18322713; 18419753; 18427551; 18457658; 18678285; 18719857; 18727839; 18780967; 19086053; 19115484; 19120874; 19167335; 19169037; 19177265; 19250380; 19330021; 19386345; 19399531; 19417027; 19435634; 19453261; 19564412; 19598235; 19635108; 19651702; 19730683; 19734938; 19749791; 19758420; 19816090; 19883730; 19913121; 19945432; 19953087; 19957796; 20003389; 20186105; 20209132; 20219210; 20301434; 20301726; 20424473; 20542022; 20600627; 20628086; 20663926; 20680486; 20854189; 20943663; 20977883; 2112345…
description: neurotrophic tyrosine kinase, receptor, type 1
database cross reference: Ensembl:ENSG00000198400
database cross reference: HGNC:8031
database cross reference: HPRD:01869
database cross reference: MIM:191315
database cross reference: Vega:OTTHUMG00000041304

NTRK2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GP145-TrkB
alternative term: TRKB
alternative term: trk-B
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NTRK2
full name from nomenclature authority: neurotrophic tyrosine kinase, receptor, type 2
NCBI GeneID: 4915
NCBI LocusTag: RP11-263K15.1
gene map location: 9q22.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001570 (EC: IEA); GO_0001764 (EC: ISS); GO_0005524 (EC: IEA); GO_0005829 (EC: IEA); GO_0005887 (EC: IDA, PMID: 15494731); GO_0007169 (EC: TAS); GO_0007190 (EC: TAS); GO_0007528 (EC: IEA); GO_0007568 (EC: IEA); GO_0007612 (EC: ISS); GO_0007616 (EC: IEA); GO_0007631 (EC: IEA); GO_0008284 (EC: ISS); GO_0009986 (EC: IEA); GO_0010008 (EC: IEA); GO_0010628 (EC: ISS); GO_0010976 (EC: ISS); GO_0010996 (EC: IEA); GO_0014047 (EC: IEA); GO_0014068 (EC: ISS); GO_0014069 (EC: IEA); GO_0021954 (EC: ISS); GO_0021987 (EC: ISS); GO_0030182 (EC: ISS); GO_0030426 (EC: IEA); GO_0031547 (EC: IMP, PMID: 15494731); GO_0032314 (EC: ISS); GO_0035584 (EC: IEA); GO_0042490 (EC: IEA); GO_0042803 (EC: ISS); GO_0043025 (EC: IEA); GO_0043121 (EC: IDA, PMID: 11738045); GO_0043121 (EC: ISS); GO_0043195 (EC: IEA); GO_0043197 (EC: IEA); GO_0043235 (EC: IDA); GO_0043410 (EC: ISS); GO_0043524 (EC: ISS); GO_0045211 (EC: IEA); GO_0046548 (EC: IEA); GO_0046777 (EC: ISS); GO_0046875 (EC: IEA); GO_0046928 (EC: IEA); GO_0048011 (EC: TAS); GO_0048403 (EC: ISS); GO_0048709 (EC: IEA); GO_0048786 (EC: IEA); GO_0048935 (EC: IEA); GO_0050772 (EC: ISS); GO_0050773 (EC: IEA); GO_0051896 (EC: IEA); GO_0051968 (EC: IEA); GO_0060076 (EC: IEA); GO_0060175 (EC: IMP, PMID: 15494731); GO_0060291 (EC: IEA); GO_2000811 (EC: IEA)
has PubMed association: PMID: 1645620; 1710174; 7574684; 7679912; 7759111; 7789988; 7823156; 7936202; 8621424; 8895847; 9195161; 9312147; 9507002; 9573364; 9648856; 9856458; 9927421; 10092678; 10386953; 10388563; 10490030; 10533983; 10631974; 11157096; 11162451; 11251075; 11263982; 11432792; 11738045; 11798182; 11849294; 11855816; 12006576; 12074588; 12237455; 12367511; 12419535; 12471037; 12477932; 12719654; 12808116; 12912764; 12921913; 14617818; 14702039; 15024057; 15167895; 15304335; 15329723; 15389758; 15489334; 15494731; 15513915; 15637590; 15647480; 15657181; 15838534; 16034442; 16051641; 16113645; 16335952; 16647839; 16648150; 16701206; 16713371; 16713586; 16786155; 16805430; 16862449; 16939974; 16964397; 17008023; 17200667; 17570738; 17611278; 17616679; 17674765; 17720314; 17873329; 17884018; 17889702; 17918233; 17971243; 18075316; 18201274; 18203754; 18253057; 18286198; 18293376; 18319596; 18428117; 18457658; 18511296; 18534558; 18595003; 18637190; 18678285; 18727839; 18780967; 18959266; 18992902; 19018715; 19086053; 19087522; 19124685; 19156168; 19170129; 19268276; 19307055; 19363525; 19365399; 19386345; 19403818; 19417027; 19453261; 19488044; 19548263; 19598235; 19635108; 19641488; 19741136; 19765683; 19801649; 19816090; 19844206; 19874574; 19879330; 19885622; 19913121; 19927149; 19953087; 20014955; 20083228; 20101235; 20124106; 20132184; 20156366; 20186105; 20193039; 20202475; 20219210; 20379614; 20428771; 20463055; 20468064; 20610389; 20615547; 20628086; 20662941; 20673758; 20694504; 20703101; 20811716; 20877300; 20878119; 21047554; 21079983; 21126736; 21187387; 21192928; 21215389; 21223646; 21239439; 21242122; 21295543; 21330466; 21379385; 21414899; 21419569; 21426646; 21552290; 21612826; 21670725; 21711518; 21728718; 21739244; 21750702; 21795612; 21802740; 21849537; 21849550; 21966426; 21988832; 21999199; 22020324; 22028443; 22209410; 22258407; 22322843; 22341689; 22343487; 22361863; 22393127; 22425982; 22426239; 22490895; 22609366; 22710966; 22719055; 22842573; 22886570; 2…
description: neurotrophic tyrosine kinase, receptor, type 2
database cross reference: Ensembl:ENSG00000148053
database cross reference: HGNC:8032
database cross reference: HPRD:02712
database cross reference: MIM:600456
database cross reference: Vega:OTTHUMG00000020120

NTRK3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: TRKC
alternative term: gp145(trkC)
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NTRK3
full name from nomenclature authority: neurotrophic tyrosine kinase, receptor, type 3
NCBI GeneID: 4916
gene map location: 15q25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: IDA); GO_0001764 (EC: IEA); GO_0001933 (EC: IDA); GO_0002039 (EC: IPI); GO_0004714 (EC: IEA); GO_0005030 (EC: IDA); GO_0005524 (EC: IEA); GO_0005737 (EC: IEA); GO_0005887 (EC: IEA); GO_0007169 (EC: IDA); GO_0008284 (EC: IDA); GO_0010628 (EC: IDA); GO_0019056 (EC: IEA); GO_0030335 (EC: IDA); GO_0032148 (EC: IDA); GO_0032856 (EC: IDA); GO_0033138 (EC: IDA); GO_0038179 (EC: IDA); GO_0042490 (EC: IEA); GO_0043121 (EC: TAS, PMID: 7806211); GO_0043235 (EC: IDA); GO_0045471 (EC: IEA); GO_0046777 (EC: IEA); GO_0046875 (EC: IEA); GO_0048665 (EC: IEA); GO_0048678 (EC: IEA); GO_0048691 (EC: IEA); GO_0048712 (EC: IEA); GO_0050927 (EC: IDA); GO_0051412 (EC: IEA); GO_0060548 (EC: IEA); GO_0071300 (EC: IEA); GO_0090102 (EC: IEA); GO_2000251 (EC: IDA)
has PubMed association: PMID: 1326636; 1653651; 7657612; 7806211; 7823156; 7828539; 8344249; 8619474; 8621424; 8889548; 8895847; 9110174; 9195161; 9197281; 9462753; 9488719; 9648868; 9778053; 9856458; 9927421; 9973222; 10027399; 10092678; 10764727; 11157096; 11205744; 11877382; 12006576; 12034707; 12210087; 12237455; 12399943; 12450792; 12471037; 12477932; 12927579; 14668342; 15167446; 15167895; 15198123; 15247919; 15312164; 15513915; 15932601; 16344560; 16537434; 16647839; 16648236; 16786155; 16826429; 16862449; 16941478; 17971243; 18068631; 18179783; 18203754; 18293376; 18319596; 18336001; 18347002; 18367154; 18428117; 18616610; 18639687; 18713973; 19011601; 19040714; 19086053; 19156760; 19179422; 19187638; 19344762; 19351817; 19370765; 19417027; 19453261; 19556619; 19598235; 19680743; 19893451; 20078941; 20160348; 20219210; 20379614; 20554328; 20802235; 21070662; 21139137; 21295543; 21392742; 21401966; 21552290; 21617231; 21728718; 21788388; 21832049; 21988832; 22265740; 22343487; 22388998; 22404213; 22939624; 23027130; 23332094; 23341610; 23416450; 23453885; 23832765; 23869086; 23874207; 24145651
description: neurotrophic tyrosine kinase, receptor, type 3
database cross reference: Ensembl:ENSG00000140538
database cross reference: HGNC:8033
database cross reference: HPRD:01870
database cross reference: MIM:191316
database cross reference: Vega:OTTHUMG00000148677

NTS
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NMN-125
alternative term: NN
alternative term: NT
alternative term: NT/N
alternative term: NTS1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NTS
full name from nomenclature authority: neurotensin
NCBI GeneID: 4922
gene map location: 12q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005184 (EC: IEA); GO_0005515 (EC: IPI); GO_0005576 (EC: TAS); GO_0007165 (EC: NAS, PMID: 8954810); GO_0030133 (EC: IEA); GO_0050880 (EC: IEA)
has PubMed association: PMID: 409699; 1436492; 3525564; 3670596; 6754769; 7791794; 7836437; 8075503; 8719037; 8770919; 8869556; 8954810; 9530155; 9756851; 11278902; 11559354; 11801734; 11811984; 11815627; 11906607; 11912133; 11922768; 12150975; 12473660; 12477932; 12531461; 12609826; 14699144; 14743366; 15123666; 15358593; 15489334; 15623535; 16087676; 16519961; 16754659; 16984735; 17068197; 17207965; 17289170; 17570131; 17644423; 17870207; 18048355; 18577758; 18624930; 19086053; 19393580; 19878995; 19932148; 20138826; 20468064; 20731814; 20810387; 20858966; 21030593; 21212273; 21233215; 21272935; 21508335; 21542591; 21623207; 21806946; 21994122; 22416137; 22700584; 22825476; 22849656; 23064014; 23109725; 23418512; 23436714; 23962427; 24000330; 24198343
description: neurotensin
database cross reference: Ensembl:ENSG00000133636
database cross reference: HGNC:8038
database cross reference: HPRD:08878
database cross reference: MIM:162650
database cross reference: Vega:OTTHUMG00000169832

OTC
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: OCTD
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: OTC
full name from nomenclature authority: ornithine carbamoyltransferase
NCBI GeneID: 5009
gene map location: Xp21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000050 (EC: IDA, PMID: 2556444); GO_0000050 (EC: IEA); GO_0000050 (EC: TAS); GO_0001889 (EC: IEA); GO_0004585 (EC: EXP); GO_0004585 (EC: IDA, PMID: 2556444); GO_0005543 (EC: IEA); GO_0005739 (EC: IDA); GO_0005743 (EC: IEA); GO_0005759 (EC: NAS, PMID: 6372096); GO_0005759 (EC: TAS); GO_0006526 (EC: IEA); GO_0006593 (EC: IDA, PMID: 2556444); GO_0007494 (EC: IEA); GO_0010043 (EC: IEA); GO_0016597 (EC: IEA); GO_0019240 (EC: IDA, PMID: 2556444); GO_0032868 (EC: IEA); GO_0034641 (EC: TAS); GO_0042301 (EC: IEA); GO_0042493 (EC: IEA); GO_0044281 (EC: TAS); GO_0070207 (EC: IEA); GO_0070781 (EC: IEA); GO_0097272 (EC: IMP, PMID: 2556444)
has PubMed association: PMID: 1353535; 1480464; 1602151; 1627356; 1671317; 1721894; 1757964; 2035531; 2037279; 2208768; 2347583; 2474822; 2556444; 2722850; 2741942; 2836378; 2843770; 2983225; 3170748; 3782067; 3891325; 3895227; 3943133; 6169723; 6372096; 6494904; 6942417; 7085676; 7474905; 7627182; 7860064; 7860066; 7951259; 8019569; 8081373; 8081398; 8099056; 8364586; 8530002; 8544185; 8807340; 8830175; 8863155; 8956038; 8956045; 9056557; 9065786; 9143919; 9266388; 9286441; 9756929; 9852088; 10070627; 10405441; 10502831; 10565370; 10737985; 10813810; 11260212; 11768581; 11793468; 11793483; 12083811; 12477932; 12516615; 12618087; 15300856; 15489334; 15692798; 15772651; 16712791; 16786505; 17041896; 17570074; 17570354; 17893704; 18029348; 18030415; 18204299; 18983895; 19138872; 19359120; 19475717; 19574962; 19748344; 19893582; 20127982; 20817516; 21956151; 24006547
description: ornithine carbamoyltransferase
database cross reference: Ensembl:ENSG00000036473
database cross reference: HGNC:8512
database cross reference: HPRD:02408
database cross reference: HPRD:08947
database cross reference: MIM:300461
database cross reference: Vega:OTTHUMG00000022727

OXCT1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: OXCT
alternative term: SCOT
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: OXCT1
full name from nomenclature authority: 3-oxoacid CoA transferase 1
NCBI GeneID: 5019
gene map location: 5p13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005739 (EC: IDA); GO_0005739 (EC: NAS, PMID: 10964512); GO_0005759 (EC: TAS); GO_0007420 (EC: IEA); GO_0007507 (EC: IEA); GO_0007584 (EC: IEA); GO_0008260 (EC: IMP, PMID: 10964512); GO_0008260 (EC: TAS); GO_0009725 (EC: IEA); GO_0014823 (EC: IEA); GO_0032024 (EC: IEA); GO_0042182 (EC: IEA); GO_0042493 (EC: IEA); GO_0042594 (EC: IEA); GO_0042803 (EC: NAS, PMID: 10964512); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0045471 (EC: IEA); GO_0046950 (EC: IMP, PMID: 9671268); GO_0046950 (EC: TAS); GO_0046952 (EC: TAS); GO_0060612 (EC: IEA); GO_0071229 (EC: IEA); GO_0071333 (EC: IEA)
has PubMed association: PMID: 1405472; 6150478; 8751852; 9380443; 9671268; 10964512; 11756565; 12477932; 14702039; 15489334; 15496607; 16765626; 17706444; 18029348; 18648183; 19296078; 20381070; 20652411; 20877624; 21163940; 21296660; 21565611; 21791085; 22863883; 22939629
description: 3-oxoacid CoA transferase 1
database cross reference: Ensembl:ENSG00000083720
database cross reference: HGNC:8527
database cross reference: HPRD:02001
database cross reference: MIM:601424
database cross reference: Vega:OTTHUMG00000094783

P2RX7
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: P2X7
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: P2RX7
full name from nomenclature authority: purinergic receptor P2X, ligand-gated ion channel, 7
NCBI GeneID: 5027
gene map location: 12q24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001530 (EC: ISS); GO_0001614 (EC: IDA, PMID: 9038151); GO_0002028 (EC: ISS, PMID: 17785580); GO_0004931 (EC: IDA, PMID: 9038151); GO_0005102 (EC: ISS, PMID: 17785580); GO_0005524 (EC: IC, PMID: 9038151); GO_0005639 (EC: IBA); GO_0005737 (EC: ISS); GO_0005886 (EC: ISS, PMID: 17785580); GO_0005886 (EC: TAS); GO_0005887 (EC: IC, PMID: 9038151); GO_0006812 (EC: IDA, PMID: 9038151); GO_0007166 (EC: ISS); GO_0010524 (EC: IDA, PMID: 9038151); GO_0016020 (EC: IDA, PMID: 17785580); GO_0019233 (EC: ISS); GO_0030501 (EC: ISS); GO_0032059 (EC: ISS); GO_0032060 (EC: ISS); GO_0033198 (EC: IDA, PMID: 9038151); GO_0035590 (EC: IDA, PMID: 9038151); GO_0035872 (EC: TAS); GO_0042803 (EC: NAS, PMID: 17895406); GO_0043409 (EC: ISS); GO_0045087 (EC: TAS); GO_0045779 (EC: ISS); GO_0045919 (EC: ISS); GO_0046931 (EC: IDA, PMID: 9038151); GO_0050718 (EC: IDA, PMID: 17036048); GO_0051495 (EC: ISS); GO_0051709 (EC: NAS, PMID: 17785580); GO_0051899 (EC: IDA, PMID: 9038151); GO_0097190 (EC: ISS)
has PubMed association: PMID: 8125298; 9038151; 9826911; 11150303; 11341329; 11707406; 11852049; 11943260; 12107182; 12270951; 12404161; 12422208; 12456589; 12477932; 12493261; 12586825; 12633871; 12759456; 12787128; 12874219; 12874700; 12880424; 12931211; 14510944; 14607949; 14702039; 14976257; 15004138; 15089763; 15120006; 15123679; 15155383; 15184265; 15304508; 15472991; 15475073; 15489334; 15571247; 15728711; 15777864; 15778408; 15830104; 15862308; 15896293; 15899033; 15901833; 15923180; 15942904; 15972634; 15991050; 16117789; 16228288; 16263709; 16321858; 16344560; 16424024; 16514055; 16541075; 16624800; 16673375; 16740600; 16822851; 17032903; 17036048; 17040997; 17065062; 17065105; 17095747; 17130901; 17142754; 17197037; 17257221; 17286963; 17314141; 17474147; 17482244; 17483156; 17488689; 17558311; 17785580; 17895406; 17928361; 17947359; 18040764; 18071294; 18089587; 18211888; 18268501; 18436590; 18523309; 18543274; 18545980; 18596211; 18614336; 18617511; 18676680; 18678419; 18682393; 18765670; 18801407; 18852390; 18937793; 18971257; 18987356; 19017759; 19068080; 19074885; 19076224; 19151591; 19160446; 19170196; 19186133; 19201928; 19204004; 19211924; 19225709; 19226284; 19264037; 19309360; 19328558; 19330776; 19396427; 19430700; 19453261; 19494237; 19548263; 19552691; 19625176; 19682070; 19692168; 19700502; 19748989; 19882109; 19889958; 19891999; 19913121; 19931869; 20007545; 20138022; 20164546; 20185692; 20188863; 20196868; 20226536; 20351714; 20360457; 20378545; 20379614; 20424473; 20446288; 20450227; 20453110; 20488797; 20493226; 20495003; 20508067; 20535134; 20605778; 20628086; 20661107; 20668222; 20813842; 20819262; 20837475; 20846359; 21041608; 21187936; 21205829; 21233486; 21262970; 21266468; 21335057; 21438144; 21470339; 21492831; 21508263; 21565445; 21635566; 21640086; 21645266; 21651910; 21670495; 21697458; 21821797; 21865551; 21911484; 21941410; 21978920; 21988719; 21988832; 22017219; 22048123; 22134903; 22137490; 22163032; 22183411; 22234152; 22250198; 22274585; 2229594…
description: purinergic receptor P2X, ligand-gated ion channel, 7
database cross reference: Ensembl:ENSG00000089041
database cross reference: HGNC:8537
database cross reference: HPRD:03977
database cross reference: MIM:602566

PEBP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HCNP
alternative term: HCNPpp
alternative term: HEL-210
alternative term: HEL-S-34
alternative term: PBP
alternative term: PEBP
alternative term: PEBP-1
alternative term: RKIP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PEBP1
full name from nomenclature authority: phosphatidylethanolamine binding protein 1
NCBI GeneID: 5037
gene map location: 12q24.23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004867 (EC: IEA); GO_0005515 (EC: IPI, PMID: 17097642); GO_0005524 (EC: IEA); GO_0005737 (EC: IEA); GO_0008429 (EC: TAS, PMID: 7637590); GO_0019899 (EC: IPI); GO_0019901 (EC: IPI); GO_0044822 (EC: IDA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1286669; 1602151; 7637590; 7641877; 7807553; 8125298; 8144042; 8738137; 9782050; 10490027; 10622376; 10757792; 11034991; 11585904; 11853019; 12421765; 12477932; 12551925; 14654844; 14766752; 15001550; 15327891; 15489334; 15782137; 16027165; 16169070; 16243812; 16513087; 16865242; 16916643; 17018026; 17030190; 17081983; 17097642; 17145707; 17179102; 17353931; 17474147; 17911631; 17952120; 18160415; 18172264; 18294816; 18329792; 18375747; 18483365; 18567796; 18781797; 18816836; 19034380; 19056867; 19096942; 19101508; 19103740; 19153603; 19165527; 19228192; 19291429; 19342899; 19357705; 19367706; 19405953; 19551145; 19564817; 19705153; 19779262; 19955695; 19957553; 20028985; 20043910; 20463977; 20533335; 20564197; 20682295; 20734161; 20739083; 20853079; 20855151; 20869966; 21074977; 21080875; 21139048; 21180766; 21303975; 21332389; 21426659; 21556737; 21565611; 21617351; 21664646; 21672326; 21685394; 21689459; 21732351; 21831839; 21873975; 21875465; 21890473; 21906983; 21963094; 21988832; 22031589; 22053931; 22102006; 22246605; 22248055; 22279539; 22292035; 22295570; 22373584; 22388727; 22460832; 22463874; 22492043; 22505648; 22536838; 22558375; 22562283; 22605662; 22662230; 22692503; 22809510; 22833545; 22855160; 22875620; 22899242; 22935977; 22939629; 22983529; 23000965; 23066033; 23066640; 23075684; 23095933; 23254962; 23259789; 23284715; 23359513; 23376254; 23460950; 23527098; 23632477; 23636063; 23674108; 23814485; 23824909; 23872143; 23991415; 24048798; 24395801
description: phosphatidylethanolamine binding protein 1
database cross reference: Ensembl:ENSG00000089220
database cross reference: HGNC:8630
database cross reference: HPRD:06850
database cross reference: MIM:604591
database cross reference: Vega:OTTHUMG00000168860

SERPINE1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PAI
alternative term: PAI-1
alternative term: PAI1
alternative term: PLANH1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SERPINE1
full name from nomenclature authority: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
NCBI GeneID: 5054
gene map location: 7q22.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001300 (EC: IEP, PMID: 18974388); GO_0001525 (EC: IEP, PMID: 11866539); GO_0002020 (EC: IPI, PMID: 12114510); GO_0002576 (EC: TAS); GO_0004867 (EC: IDA, PMID: 1695900); GO_0005102 (EC: IPI, Qualifier: contributes_to, PMID: 8626514); GO_0005515 (EC: IPI, PMID: 16272158); GO_0005576 (EC: IDA, PMID: 9386191); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 1695900); GO_0005886 (EC: TAS); GO_0006351 (EC: TAS); GO_0006367 (EC: TAS); GO_0007179 (EC: TAS); GO_0007596 (EC: TAS); GO_0010467 (EC: TAS); GO_0010469 (EC: IDA, PMID: 8837777); GO_0010757 (EC: IDA, PMID: 8508955); GO_0010757 (EC: IMP, PMID: 18835034); GO_0010951 (EC: IDA, PMID: 1695900); GO_0014912 (EC: IDA, PMID: 8837777); GO_0030168 (EC: TAS); GO_0030194 (EC: IMP, PMID: 9207454); GO_0030195 (EC: IC, PMID: 1695900); GO_0030198 (EC: TAS); GO_0030336 (EC: IDA, PMID: 10902815); GO_0031012 (EC: IDA, PMID: 1632457); GO_0031093 (EC: TAS); GO_0032757 (EC: IMP, PMID: 19916862); GO_0033629 (EC: IDA, PMID: 8837777); GO_0035491 (EC: IMP, PMID: 19916862); GO_0042127 (EC: IEA); GO_0042730 (EC: TAS); GO_0045766 (EC: IMP, PMID: 18835034); GO_0045944 (EC: TAS); GO_0048260 (EC: IDA, PMID: 8626514); GO_0050729 (EC: IGI, PMID: 17032919); GO_0050829 (EC: IGI, PMID: 17032919); GO_0051918 (EC: IDA, PMID: 2503541); GO_0061044 (EC: IGI, PMID: 9386191); GO_0061045 (EC: IC, PMID: 8837777); GO_0071222 (EC: IMP, PMID: 19916862); GO_0090026 (EC: IMP, PMID: 19916862); GO_1902042 (EC: IMP, PMID: 18835034); GO_2000098 (EC: IDA, PMID: 8837777); GO_2000352 (EC: IMP, PMID: 18835034)
has PubMed association: PMID: 1339823; 1435917; 1632457; 1695900; 1731226; 1870265; 2110366; 2161846; 2339362; 2430793; 2503541; 2544876; 2612914; 2820474; 2840665; 2891140; 3025016; 3026837; 3090045; 3092219; 3097076; 3132455; 3262512; 7479001; 7521069; 7522053; 7523444; 7552714; 7592875; 7892190; 8344937; 8455210; 8508955; 8607113; 8626514; 8830783; 8837777; 9065424; 9143604; 9184208; 9194591; 9202242; 9207454; 9386191; 9634700; 10209959; 10368279; 10391209; 10543954; 10731421; 10737800; 10739390; 10783396; 10902815; 10967118; 11037896; 11091191; 11113116; 11168509; 11260416; 11266465; 11289708; 11332466; 11347834; 11384978; 11385207; 11397722; 11418606; 11427204; 11454529; 11457466; 11457467; 11485022; 11522017; 11525425; 11558839; 11592048; 11734664; 11738073; 11748101; 11776328; 11780311; 11796716; 11796824; 11809921; 11816701; 11816707; 11816722; 11825444; 11827452; 11829481; 11836675; 11849662; 11858184; 11858480; 11864708; 11866539; 11877282; 11908512; 11909993; 11928807; 11934213; 11972486; 11979351; 11981424; 12006921; 12027469; 12032637; 12038776; 12057695; 12063175; 12064834; 12082592; 12086154; 12090757; 12091343; 12107743; 12110504; 12114510; 12123488; 12123491; 12124797; 12140748; 12141403; 12167592; 12181379; 12187010; 12218297; 12223472; 12353079; 12353306; 12356300; 12362251; 12362314; 12390531; 12406875; 12428096; 12431476; 12437099; 12438962; 12446192; 12468767; 12477932; 12477941; 12490312; 12499900; 12506026; 12508941; 12514663; 12518110; 12524082; 12556966; 12556967; 12589088; 12597520; 12601637; 12615788; 12632020; 12642587; 12660488; 12669121; 12670745; 12684636; 12686544; 12694086; 12694180; 12694181; 12700666; 12701125; 12707042; 12708473; 12709053; 12716314; 12719278; 12734779; 12743121; 12745435; 12748347; 12761670; 12765340; 12783120; 12801613; 12802648; 12808446; 12811828; 12816904; 12833173; 12833632; 12853948; 12856128; 12856717; 12857431; 12859287; 12867763; 12871600; 12876623; 12876625; 12888867; 12899665; 12902511; 12911596; 12958610; 12960956; 14500731;…
description: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
database cross reference: Ensembl:ENSG00000106366
database cross reference: HGNC:8583
database cross reference: HPRD:01418
database cross reference: MIM:173360
database cross reference: Vega:OTTHUMG00000157107

PCBP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HEL-S-85
alternative term: HNRPE1
alternative term: HNRPX
alternative term: hnRNP-E1
alternative term: hnRNP-X
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PCBP1
full name from nomenclature authority: poly(rC) binding protein 1
NCBI GeneID: 5093
gene map location: 2p13-p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000398 (EC: TAS); GO_0003697 (EC: IDA, PMID: 8152927); GO_0003723 (EC: IDA, PMID: 7556077); GO_0005515 (EC: IPI, PMID: 16713569); GO_0005654 (EC: TAS); GO_0005737 (EC: IEA); GO_0008380 (EC: TAS); GO_0010467 (EC: TAS); GO_0030529 (EC: IEA); GO_0044822 (EC: IDA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 7556077; 7607214; 8152927; 8833161; 8855318; 9234743; 10373504; 10455157; 10936052; 11591653; 11790298; 12011088; 12226669; 12414943; 12431987; 12477932; 12527772; 12890803; 12933794; 12970749; 14612387; 15169918; 15246275; 15302935; 15456888; 15489334; 15514164; 15635413; 15933215; 16248985; 16341674; 16510139; 16713569; 16775011; 16964243; 17081983; 17207965; 17314511; 17332742; 17361185; 17383969; 17389360; 17451601; 17622584; 17643375; 18457437; 18511687; 18656558; 18781797; 18850631; 19056867; 19166625; 19211566; 19322201; 19471022; 19727227; 19738201; 19808671; 20020773; 20360068; 20361869; 20462248; 20519371; 20609352; 20811636; 21110914; 21139048; 21145461; 21319273; 21549307; 21575865; 21752917; 21832049; 21853274; 21890473; 21906983; 21930702; 21963094; 21987572; 21988832; 22102042; 22105485; 22118674; 22268729; 22304920; 22354994; 22365833; 22412018; 22505724; 22623428; 22673507; 22801034; 22863883; 22939629; 23000965; 23246001; 23398456; 23402259; 23438482; 23439585; 23463506; 23478261; 23602568; 23629627; 23640898; 23798571; 23862649; 23940783; 24457600
description: poly(rC) binding protein 1
database cross reference: Ensembl:ENSG00000169564
database cross reference: HGNC:8647
database cross reference: HPRD:03128
database cross reference: MIM:601209
database cross reference: Vega:OTTHUMG00000129645

PCBP2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HNRNPE2
alternative term: HNRPE2
alternative term: hnRNP-E2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PCBP2
full name from nomenclature authority: poly(rC) binding protein 2
NCBI GeneID: 5094
gene map location: 12q13.13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000398 (EC: TAS); GO_0003677 (EC: IEA); GO_0003723 (EC: IDA, PMID: 7607214); GO_0005515 (EC: IPI, PMID: 16713569); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0008380 (EC: TAS); GO_0010467 (EC: TAS); GO_0016071 (EC: NAS, PMID: 7556077); GO_0019899 (EC: IPI, PMID: 19881509); GO_0030529 (EC: IEA); GO_0031625 (EC: IPI, PMID: 19881509); GO_0032480 (EC: TAS); GO_0043161 (EC: IMP, PMID: 19881509); GO_0044822 (EC: IDA); GO_0045087 (EC: TAS); GO_0050687 (EC: IMP, PMID: 19881509); GO_0051607 (EC: IEA)
has PubMed association: PMID: 7556077; 7607214; 8125298; 8833161; 8855318; 8871564; 9223526; 9234743; 10068686; 10373504; 10455157; 10772858; 10936052; 11747608; 12011088; 12226669; 12414943; 12477932; 12515719; 12527772; 12970749; 14612387; 14702039; 15231748; 15331611; 15489334; 16094384; 16186123; 16196087; 16341674; 16713569; 17081983; 17145707; 17183366; 17219427; 17327219; 17426136; 17526645; 17581994; 17643375; 17672918; 18029348; 18086560; 18174314; 18252259; 18457437; 18656221; 18687895; 18701464; 18781797; 18850631; 18929541; 19029303; 19211566; 19230839; 19322201; 19471022; 19738201; 19808671; 19881509; 19945132; 20000738; 20020773; 20211135; 20360068; 20946988; 21081666; 21110914; 21139048; 21145461; 21252943; 21319273; 21632751; 21723381; 21752917; 21853274; 21890473; 21906983; 21963094; 21987572; 21988832; 22022391; 22079093; 22118674; 22268729; 22365833; 22379092; 22431556; 22438951; 22505724; 22623428; 22633452; 22797925; 22939629; 22990118; 23000965; 23246001; 23438482; 23455922; 23463506; 23585479; 23629627; 23640898; 23798571; 24250222; 24457600
description: poly(rC) binding protein 2
database cross reference: Ensembl:ENSG00000197111
database cross reference: HGNC:8648
database cross reference: HPRD:03129
database cross reference: MIM:601210
database cross reference: Vega:OTTHUMG00000169439

PCK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PEPCK-C
alternative term: PEPCK1
alternative term: PEPCKC
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PCK1
full name from nomenclature authority: phosphoenolpyruvate carboxykinase 1 (soluble)
NCBI GeneID: 5105
gene map location: 20q13.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000287 (EC: IDA, PMID: 11851336); GO_0004613 (EC: ISS); GO_0005525 (EC: IDA, PMID: 11851336); GO_0005737 (EC: ISS); GO_0005829 (EC: TAS); GO_0005975 (EC: TAS); GO_0006006 (EC: IMP, PMID: 14764811); GO_0006006 (EC: TAS); GO_0006094 (EC: IEA); GO_0006094 (EC: ISS); GO_0006094 (EC: TAS); GO_0006107 (EC: IEA); GO_0006475 (EC: IDA); GO_0014823 (EC: IEA); GO_0017144 (EC: TAS); GO_0019003 (EC: IEA); GO_0030145 (EC: IDA, PMID: 11851336); GO_0031406 (EC: IDA, PMID: 11851336); GO_0032868 (EC: IDA, PMID: 14764811); GO_0042593 (EC: ISS); GO_0044281 (EC: TAS); GO_0046327 (EC: ISS); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1492743; 1657985; 2993287; 8325643; 8432541; 8490617; 8547315; 11689615; 11780052; 11851336; 11997389; 12237288; 12324453; 12477932; 14744869; 14764811; 15046742; 15489334; 15951444; 16132948; 16144962; 16282543; 16341674; 16344560; 16620271; 16978381; 17192490; 17440948; 17495004; 18029348; 18460190; 18492826; 18660489; 18801732; 18830724; 18976975; 18996102; 19021757; 19056482; 19056867; 19070910; 19329064; 19578796; 19725958; 19913121; 20098747; 20134411; 20574532; 20602615; 20628086; 20682687; 20691246; 20800603; 21145461; 21152065; 21726808; 21832049; 21906983; 21988832; 22489460; 23092637; 23149075; 23300278; 23465595; 23940030
description: phosphoenolpyruvate carboxykinase 1 (soluble)
database cross reference: Ensembl:ENSG00000124253
database cross reference: HGNC:8724
database cross reference: HPRD:02028
database cross reference: MIM:614168
database cross reference: Vega:OTTHUMG00000032825

PCSK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BMIQ12
alternative term: NEC1
alternative term: PC1
alternative term: PC3
alternative term: SPC3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PCSK1
full name from nomenclature authority: proprotein convertase subtilisin/kexin type 1
NCBI GeneID: 5122
gene map location: 5q15-q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004252 (EC: IBA); GO_0004252 (EC: ISS); GO_0004252 (EC: TAS); GO_0005615 (EC: IDA, PMID: 8397508); GO_0005794 (EC: IBA); GO_0006508 (EC: TAS, PMID: 9207799); GO_0007267 (EC: TAS, PMID: 9207799); GO_0008152 (EC: TAS, PMID: 9207799); GO_0016486 (EC: TAS); GO_0030133 (EC: IEA); GO_0034774 (EC: TAS); GO_0043043 (EC: ISS); GO_0044267 (EC: TAS); GO_0050796 (EC: TAS)
has PubMed association: PMID: 1547893; 1597471; 1605851; 1765368; 2061332; 3053705; 3542996; 4368999; 7639757; 7797529; 7836407; 8163529; 8397508; 8557106; 8666140; 8916141; 8940009; 8995623; 9207799; 9213372; 9521468; 10037747; 10087454; 10391209; 10409610; 10530621; 10771309; 10931181; 11113628; 11246872; 11435430; 11720250; 11739459; 12126783; 12147786; 12147787; 12477932; 12715715; 14574455; 14614908; 14617756; 15126519; 15127203; 15807527; 16293189; 16344560; 16644867; 16928730; 17595246; 17917309; 17990211; 18096669; 18343183; 18549351; 18604207; 19034419; 19164386; 19339735; 19528091; 19628676; 19641380; 19875984; 19876004; 19913121; 20106974; 20498726; 20534142; 20571754; 20628086; 20734064; 21030982; 21720444; 21805236; 21805237; 21873549; 21935364; 22000902; 22210313; 22344219; 22552345; 22581228; 22592666; 22679642; 22737226; 23121087; 23383060; 23451278; 23775089; 23800642; 23903356; 23966867; 24140494; 24226266
description: proprotein convertase subtilisin/kexin type 1
database cross reference: Ensembl:ENSG00000175426
database cross reference: HGNC:8743
database cross reference: HPRD:01201
database cross reference: MIM:162150
database cross reference: Vega:OTTHUMG00000122089

PDHA1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PDHA
alternative term: PDHCE1A
alternative term: PHE1A
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PDHA1
full name from nomenclature authority: pyruvate dehydrogenase (lipoamide) alpha 1
NCBI GeneID: 5160
NCBI LocusTag: RP11-723P2.1
gene map location: Xp22.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004738 (EC: IDA, PMID: 19081061); GO_0004739 (EC: IEA); GO_0005739 (EC: IDA); GO_0005759 (EC: TAS); GO_0006086 (EC: IDA, PMID: 19081061); GO_0006090 (EC: TAS); GO_0006096 (EC: IEA); GO_0006099 (EC: IDA, PMID: 19081061); GO_0010510 (EC: TAS); GO_0044237 (EC: TAS); GO_0044281 (EC: TAS); GO_0045254 (EC: IDA, PMID: 19081061)
has PubMed association: PMID: 1293379; 1301207; 1338114; 1551669; 1907799; 1909401; 2227443; 2377599; 2537010; 2737678; 2745444; 2748588; 2828359; 3034892; 3422424; 7273846; 7545958; 7573035; 7757088; 7782287; 7853374; 7864652; 7887409; 7967473; 8032855; 8125298; 8199595; 8498846; 8504306; 8664900; 8844217; 9003499; 9029794; 9671272; 9686362; 9799265; 10077682; 10679936; 11485553; 11486000; 12477932; 12651851; 12676647; 14638692; 14708897; 15302935; 15489334; 15861126; 16169070; 16196087; 16344560; 16713755; 16967364; 17065338; 17081983; 17353931; 17947500; 17957032; 18023225; 18398624; 19081061; 19517265; 19586787; 19615732; 20002461; 20562859; 20958858; 21139048; 21145461; 21470495; 21723463; 21809123; 21852536; 21890473; 21895644; 21914562; 21963094; 22142326; 22586326; 22623428; 22750801; 22863883; 22939629; 23798571; 23842279
description: pyruvate dehydrogenase (lipoamide) alpha 1
database cross reference: Ensembl:ENSG00000131828
database cross reference: HGNC:8806
database cross reference: HPRD:02420
database cross reference: MIM:300502
database cross reference: Vega:OTTHUMG00000021224

PDK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PDK1
full name from nomenclature authority: pyruvate dehydrogenase kinase, isozyme 1
NCBI GeneID: 5163
gene map location: 2q31.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004672 (EC: IDA, PMID: 17683942); GO_0004674 (EC: IEA); GO_0004740 (EC: IDA, PMID: 7499431); GO_0004740 (EC: IMP); GO_0005515 (EC: IPI, PMID: 17110931); GO_0005524 (EC: IEA); GO_0005739 (EC: TAS, PMID: 7499431); GO_0005759 (EC: TAS); GO_0005967 (EC: IEA); GO_0006006 (EC: IEA); GO_0006090 (EC: TAS); GO_0006468 (EC: IDA, PMID: 17683942); GO_0006468 (EC: IMP); GO_0008283 (EC: IMP, PMID: 18541534); GO_0008631 (EC: IMP, PMID: 18541534); GO_0010510 (EC: TAS); GO_0010906 (EC: IMP, PMID: 18541534); GO_0044237 (EC: TAS); GO_0044281 (EC: TAS); GO_0097411 (EC: IMP)
has PubMed association: PMID: 7499431; 7864652; 10567431; 10753910; 11279232; 11485553; 11486000; 11733037; 11889038; 11978179; 12150926; 12477932; 12573248; 12676647; 14702039; 14718574; 14966024; 15489334; 15591305; 15678105; 16344560; 16517405; 17110931; 17314099; 17683942; 17785433; 18003900; 18541534; 18542064; 18954447; 19010391; 20415663; 20416077; 20877624; 21775285; 21900206; 22347420; 22623531; 22704111; 22948140; 23135628; 23300259; 24044887
description: pyruvate dehydrogenase kinase, isozyme 1

PFKM
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GSD7
alternative term: PFK-1
alternative term: PFK1
alternative term: PFKA
alternative term: PFKX
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PFKM
full name from nomenclature authority: phosphofructokinase, muscle
NCBI GeneID: 5213
gene map location: 12q13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003872 (EC: IDA, PMID: 6444721); GO_0003872 (EC: IMP, PMID: 6444532); GO_0003872 (EC: ISS); GO_0005515 (EC: IPI, PMID: 12649290); GO_0005524 (EC: IDA, PMID: 8780720); GO_0005829 (EC: TAS); GO_0005945 (EC: IDA, PMID: 6444532); GO_0005975 (EC: TAS); GO_0006002 (EC: IDA, PMID: 6444721); GO_0006002 (EC: IMP, PMID: 6444532); GO_0006006 (EC: TAS); GO_0006096 (EC: IEA); GO_0006096 (EC: IMP, PMID: 6444532); GO_0006096 (EC: TAS); GO_0008022 (EC: IPI, PMID: 12649290); GO_0016324 (EC: IDA, PMID: 12649290); GO_0019900 (EC: IPI, PMID: 6444721); GO_0032024 (EC: IEA); GO_0042593 (EC: IEA); GO_0042802 (EC: IPI, PMID: 6444721); GO_0044281 (EC: TAS); GO_0046716 (EC: IMP, PMID: 6444532); GO_0046835 (EC: IDA, PMID: 6444721); GO_0046835 (EC: IMP, PMID: 6444532); GO_0046835 (EC: ISS); GO_0046872 (EC: IEA); GO_0051259 (EC: IDA, PMID: 6444721); GO_0070061 (EC: IDA, PMID: 8780720)
has PubMed association: PMID: 125160; 156693; 1833270; 2140567; 2140573; 2526044; 2526045; 2822475; 6444532; 6444721; 6459054; 7479776; 7513946; 7550225; 7825568; 8444874; 8661033; 8780720; 8889548; 8889589; 9252390; 9389749; 9443500; 10187848; 12432079; 12477932; 12649290; 14760703; 15020257; 15489334; 16344560; 17544406; 17549794; 18029348; 18624398; 18781797; 18854154; 18996102; 19019082; 19165527; 19394292; 20379614; 20483646; 20602615; 20800603; 20849852; 21124851; 21139048; 21145461; 21573193; 21890473; 21906983; 21963094; 21988832; 22133655; 22268729; 22474333; 22863883; 22939629; 22995305; 23088713; 24211586
description: phosphofructokinase, muscle
database cross reference: Ensembl:ENSG00000152556
database cross reference: HGNC:8877
database cross reference: HPRD:01988
database cross reference: MIM:610681
database cross reference: Vega:OTTHUMG00000169898

PGGT1B
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BGGI
alternative term: GGTI
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PGGT1B
full name from nomenclature authority: protein geranylgeranyltransferase type I, beta subunit
NCBI GeneID: 5229
gene map location: 5q22.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004661 (EC: IDA, PMID: 16893176); GO_0004662 (EC: ISS); GO_0005953 (EC: IDA, PMID: 16893176); GO_0008270 (EC: ISS); GO_0008284 (EC: IEA); GO_0018344 (EC: IDA, PMID: 16893176); GO_0034097 (EC: IEA); GO_0045787 (EC: IEA); GO_0051771 (EC: IEA)
has PubMed association: PMID: 1400319; 7713879; 8106351; 11076863; 12477932; 14598891; 15451670; 16344560; 16893176; 19667218; 20403997; 20446922; 21906983; 22160308; 22632162; 22863883; 23475391
description: protein geranylgeranyltransferase type I, beta subunit
database cross reference: Ensembl:ENSG00000164219
database cross reference: HGNC:8895
database cross reference: HPRD:03612
database cross reference: MIM:602031
database cross reference: Vega:OTTHUMG00000128893

PGK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HEL-S-68p
alternative term: MIG10
alternative term: PGKA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PGK1
full name from nomenclature authority: phosphoglycerate kinase 1
NCBI GeneID: 5230
NCBI LocusTag: RP4-570L12.1
gene map location: Xq13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004618 (EC: EXP); GO_0004618 (EC: ISS); GO_0005515 (EC: IPI); GO_0005524 (EC: ISS); GO_0005829 (EC: TAS); GO_0005975 (EC: TAS); GO_0006006 (EC: TAS); GO_0006094 (EC: TAS); GO_0006096 (EC: IEA); GO_0006096 (EC: TAS); GO_0016310 (EC: ISS); GO_0030855 (EC: IEP); GO_0044281 (EC: TAS); GO_0070062 (EC: IDA, PMID: 11487543)
has PubMed association: PMID: 1533225; 1547346; 1586722; 1602151; 1837552; 2001457; 2324090; 2347494; 2814502; 2995995; 3453121; 6099325; 6188151; 6933565; 6941312; 7391027; 7391028; 7440217; 7892275; 8043870; 8075252; 8089148; 8122886; 8615693; 8673469; 8889548; 9023984; 9075577; 9744480; 10720297; 11130727; 11487543; 11745195; 12080078; 12174867; 12477932; 12488440; 12869554; 14733918; 14764427; 15053920; 15161933; 15255553; 15489334; 15592455; 15952740; 16009940; 16196087; 16236267; 16263121; 16363799; 16567715; 17043677; 17081983; 17148452; 17565005; 17661373; 18039033; 18096512; 18288812; 18453750; 18540639; 18603805; 18781797; 19110265; 19135240; 19688824; 19738201; 19778949; 19854185; 20000738; 20068185; 20360068; 20391533; 20562859; 20849852; 21081666; 21110914; 21139048; 21145461; 21319273; 21349853; 21505655; 21549683; 21565611; 21780947; 21853274; 21890473; 21906983; 21963094; 22053931; 22079093; 22145905; 22348148; 22505724; 22586326; 22619369; 22742733; 22939629; 23000965; 23077236; 23130662; 23336698; 23684636; 23703321; 23727790; 23824909; 23862649; 24284928; 24376734
description: phosphoglycerate kinase 1
database cross reference: Ensembl:ENSG00000102144
database cross reference: HGNC:8896
database cross reference: HPRD:02412
database cross reference: MIM:311800

PGK2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HEL-S-272
alternative term: PGKB
alternative term: PGKPS
alternative term: dJ417L20.2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PGK2
full name from nomenclature authority: phosphoglycerate kinase 2
NCBI GeneID: 5232
gene map location: 6p12.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004618 (EC: ISS); GO_0004618 (EC: NAS, PMID: 3453121); GO_0005524 (EC: ISS); GO_0005737 (EC: IEA); GO_0006096 (EC: IEA); GO_0006096 (EC: NAS, PMID: 3453121); GO_0016310 (EC: ISS); GO_0016310 (EC: NAS, PMID: 3453121)
has PubMed association: PMID: 1278465; 2027764; 2032717; 2156237; 2767684; 2813402; 2886978; 2987238; 3453121; 3839763; 6328504; 6873461; 9023984; 10330089; 12477932; 14574404; 15489334; 16196087; 16344560; 18976975; 19333399; 20459611; 21853274; 21890473; 21906983; 21963094; 22505724; 23000965
description: phosphoglycerate kinase 2
database cross reference: Ensembl:ENSG00000170950
database cross reference: HGNC:8898
database cross reference: HPRD:01393
database cross reference: MIM:172270
database cross reference: Vega:OTTHUMG00000014824

PGM3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AGM1
alternative term: PAGM
alternative term: PGM 3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PGM3
full name from nomenclature authority: phosphoglucomutase 3
NCBI GeneID: 5238
gene map location: 6q14.1-q15
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000287 (EC: IEA); GO_0004610 (EC: IDA, PMID: 11004509); GO_0004614 (EC: IEA); GO_0005575 (EC: ND); GO_0005829 (EC: IBA); GO_0005829 (EC: TAS); GO_0006041 (EC: NAS, PMID: 11004509); GO_0006048 (EC: IBA); GO_0006048 (EC: IEA); GO_0006048 (EC: TAS); GO_0006488 (EC: TAS); GO_0007283 (EC: IEA); GO_0009790 (EC: IEA); GO_0018279 (EC: TAS); GO_0019255 (EC: IEA); GO_0030097 (EC: IBA); GO_0043687 (EC: TAS); GO_0044267 (EC: TAS)
has PubMed association: PMID: 203189; 468082; 508567; 6461922; 8125298; 10721701; 11004509; 12174217; 12477932; 12752494; 14574404; 14702039; 15489334; 16344560; 20221814; 20800603; 21139048; 21145461; 21159204; 21832049; 21890473; 21906983; 21963094; 23000965; 23042605; 23824909
description: phosphoglucomutase 3
database cross reference: Ensembl:ENSG00000013375
database cross reference: HGNC:8907
database cross reference: HPRD:01390
database cross reference: MIM:172100
database cross reference: Vega:OTTHUMG00000015110

SERPINI1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PI12
alternative term: neuroserpin
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SERPINI1
full name from nomenclature authority: serpin peptidase inhibitor, clade I (neuroserpin), member 1
NCBI GeneID: 5274
gene map location: 3q26.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004867 (EC: IBA); GO_0005615 (EC: IEA); GO_0007417 (EC: TAS, PMID: 9070919); GO_0007422 (EC: TAS, PMID: 9070919); GO_0008219 (EC: IEA); GO_0010951 (EC: IBA); GO_0030155 (EC: IEA); GO_0030162 (EC: IBA)
has PubMed association: PMID: 9070919; 9407089; 10517635; 10992299; 11880376; 12103288; 12228252; 12354288; 12477932; 14983220; 15090543; 15269833; 15291813; 15489334; 15664988; 16344560; 16849336; 17212813; 17606885; 17961231; 18029348; 18051703; 18391951; 18591508; 19222708; 19265707; 19423540; 19423713; 20406964; 20438785; 20691191; 21081089; 21174006; 21487809; 21507957; 21569344; 21961602; 23534349; 24172014
description: serpin peptidase inhibitor, clade I (neuroserpin), member 1
database cross reference: Ensembl:ENSG00000163536
database cross reference: HGNC:8943
database cross reference: HPRD:03901
database cross reference: MIM:602445
database cross reference: Vega:OTTHUMG00000158450

PLA2G1B
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PLA2
alternative term: PLA2A
alternative term: PPLA2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PLA2G1B
full name from nomenclature authority: phospholipase A2, group IB (pancreas)
NCBI GeneID: 5319
gene map location: 12q24.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: ISS, PMID: 15528384); GO_0002446 (EC: ISS, PMID: 16005851); GO_0004623 (EC: IDA, PMID: 1918029); GO_0005102 (EC: IDA, PMID: 1918029); GO_0005102 (EC: IPI, PMID: 7721806); GO_0005509 (EC: IDA, PMID: 7060561); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 7060561); GO_0006633 (EC: IDA, PMID: 1918029); GO_0006644 (EC: TAS); GO_0006654 (EC: TAS); GO_0007015 (EC: TAS, PMID: 9886417); GO_0007165 (EC: TAS, PMID: 9886417); GO_0009986 (EC: IDA, PMID: 1918029); GO_0010524 (EC: ISS, PMID: 15528384); GO_0015758 (EC: ISS, PMID: 1918029); GO_0019370 (EC: ISS, PMID: 16005851); GO_0030141 (EC: IEA); GO_0030593 (EC: ISS, PMID: 16005851); GO_0032052 (EC: ISS, PMID: 7060561); GO_0032431 (EC: TAS, PMID: 17981679); GO_0032637 (EC: ISS, PMID: 15528384); GO_0032869 (EC: ISS, PMID: 1918029); GO_0035556 (EC: ISS, PMID: 15528384); GO_0036148 (EC: TAS); GO_0036149 (EC: TAS); GO_0036150 (EC: TAS); GO_0036151 (EC: TAS); GO_0036152 (EC: TAS); GO_0044240 (EC: IDA, PMID: 7060561); GO_0044281 (EC: TAS); GO_0045740 (EC: IDA, PMID: 1918029); GO_0045944 (EC: ISS, PMID: 15528384); GO_0046470 (EC: IDA, PMID: 7060561); GO_0046474 (EC: TAS); GO_0047498 (EC: IDA, PMID: 7060561); GO_0048146 (EC: IC, PMID: 1918029); GO_0050482 (EC: TAS, PMID: 12423354); GO_0050714 (EC: TAS, PMID: 17981679); GO_0050778 (EC: ISS, PMID: 16005851); GO_0051092 (EC: ISS, PMID: 15528384)
has PubMed association: PMID: 1918029; 2052621; 3028739; 6349696; 6477929; 7060561; 7584826; 7590434; 7721806; 8175726; 8300559; 8358438; 9188469; 9377118; 9745929; 9847074; 9848887; 9886417; 10509674; 10551547; 10735945; 10873103; 10905638; 10964913; 11025364; 11353443; 11510783; 11807183; 11851982; 12423354; 12477932; 12759552; 14557262; 14998370; 15220446; 15489334; 15528384; 15736947; 16005851; 16391564; 16392040; 16495221; 16541075; 16567514; 17065600; 17223797; 17434532; 17470210; 17488462; 17981679; 18212756; 18492292; 18636547; 19297324; 19913121; 20536387; 20628086; 21988832; 22528125; 22680611
description: phospholipase A2, group IB (pancreas)
database cross reference: Ensembl:ENSG00000170890
database cross reference: HGNC:9030
database cross reference: HPRD:01396
database cross reference: MIM:172410
database cross reference: Vega:OTTHUMG00000169343

PLA2G4A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PLA2G4
alternative term: cPLA2-alpha
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PLA2G4A
full name from nomenclature authority: phospholipase A2, group IVA (cytosolic, calcium-dependent)
NCBI GeneID: 5321
gene map location: 1q25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004622 (EC: IEA); GO_0004623 (EC: IDA, PMID: 8702602); GO_0004623 (EC: NAS, PMID: 8381049); GO_0004623 (EC: TAS); GO_0005509 (EC: IDA, PMID: 9430701); GO_0005544 (EC: IDA, PMID: 9665851); GO_0005737 (EC: IDA); GO_0005743 (EC: TAS); GO_0005789 (EC: TAS); GO_0005794 (EC: IEA); GO_0005829 (EC: NAS, PMID: 8381049); GO_0005829 (EC: TAS); GO_0006644 (EC: TAS); GO_0006654 (EC: TAS); GO_0006663 (EC: NAS, PMID: 9430701); GO_0006690 (EC: NAS, PMID: 9430701); GO_0007596 (EC: TAS); GO_0009395 (EC: IEA); GO_0016023 (EC: IEA); GO_0019369 (EC: TAS); GO_0030168 (EC: TAS); GO_0035965 (EC: TAS); GO_0036148 (EC: TAS); GO_0036149 (EC: TAS); GO_0036150 (EC: TAS); GO_0036151 (EC: TAS); GO_0036152 (EC: TAS); GO_0042127 (EC: IEA); GO_0044281 (EC: TAS); GO_0046456 (EC: IEA); GO_0046474 (EC: TAS); GO_0047498 (EC: EXP); GO_0050482 (EC: IEA); GO_0071236 (EC: IEA)
has PubMed association: PMID: 1869522; 1904318; 7782073; 7800505; 7862535; 7999086; 8083230; 8175726; 8381049; 8612580; 8636128; 8702602; 8910365; 9239738; 9377118; 9430701; 9468497; 9665851; 9745929; 9875225; 10085124; 10319815; 10625659; 10978317; 11416127; 12048163; 12050227; 12124392; 12414998; 12477932; 12765847; 12885780; 14609334; 14686920; 14726390; 14769798; 14963030; 15007070; 15041036; 15118355; 15259375; 15276701; 15294900; 15302935; 15305015; 15318030; 15331599; 15358156; 15475363; 15489334; 15789617; 15862967; 15975962; 16181776; 16221889; 16344560; 16407173; 16409471; 16462602; 16585943; 16603549; 16710414; 16754327; 16829784; 16963226; 16964243; 17081983; 17178883; 17344094; 17417066; 17460547; 17629734; 17672871; 17685590; 17873281; 17901074; 17971499; 17976189; 18029351; 18280113; 18388244; 18451993; 18471798; 18502815; 18562188; 18566601; 18583979; 18632668; 18665843; 18686860; 18781797; 18818748; 18840708; 19019335; 19091957; 19176526; 19237603; 19280714; 19336370; 19401382; 19450127; 19527514; 19560328; 19625654; 19632995; 19675210; 19717620; 19753100; 19778898; 19795129; 19913121; 20034614; 20056178; 20066429; 20069553; 20112044; 20140262; 20203101; 20211985; 20227521; 20351714; 20379614; 20392485; 20435073; 20464283; 20478385; 20628086; 20635443; 20643646; 20705608; 20802406; 20808133; 21097525; 21127289; 21139048; 21148506; 21185392; 21198294; 21247147; 21268080; 21315000; 21478406; 21536681; 21771656; 21825068; 21862584; 21896865; 21906983; 21963094; 22003202; 22138395; 22274867; 22378731; 22398721; 22456504; 22648535; 22728329; 22863883; 22895089; 22911431; 22939629; 22949513; 23043861; 23219238; 23268370; 23307260; 23801329
description: phospholipase A2, group IVA (cytosolic, calcium-dependent)
database cross reference: Ensembl:ENSG00000116711
database cross reference: HGNC:9035
database cross reference: HPRD:08986
database cross reference: MIM:600522
database cross reference: Vega:OTTHUMG00000035512

PLAT
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: T-PA
alternative term: TPA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PLAT
full name from nomenclature authority: plasminogen activator, tissue
NCBI GeneID: 5327
gene map location: 8p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001666 (EC: IEA); GO_0004252 (EC: IDA, PMID: 1695900); GO_0004252 (EC: TAS); GO_0005515 (EC: IPI, PMID: 10340997); GO_0005576 (EC: TAS); GO_0005615 (EC: IEA); GO_0005737 (EC: IDA, PMID: 1632457); GO_0006464 (EC: TAS, PMID: 3087818); GO_0006508 (EC: TAS, PMID: 3087818); GO_0007596 (EC: TAS); GO_0009986 (EC: IDA, PMID: 1632457); GO_0014909 (EC: IEA); GO_0030141 (EC: IEA); GO_0031012 (EC: IDA, Qualifier: NOT, PMID: 1632457); GO_0031639 (EC: IDA, PMID: 12694198); GO_0035249 (EC: IEA); GO_0042730 (EC: TAS); GO_0043434 (EC: IEA); GO_0045177 (EC: IEA); GO_0045202 (EC: IEA); GO_0045861 (EC: IDA, PMID: 1695900); GO_0048008 (EC: IEA); GO_0048167 (EC: IEA); GO_0051384 (EC: IEA); GO_0051591 (EC: IEA); GO_0060279 (EC: IEA); GO_0070062 (EC: IDA)
has PubMed association: PMID: 1301152; 1310033; 1368681; 1502153; 1602484; 1632457; 1645336; 1695900; 1762144; 1783394; 1900431; 1901789; 1909331; 1930175; 2107490; 2107528; 2110366; 2496749; 2503541; 2513186; 2551064; 2558718; 2745554; 2838384; 2962641; 3009482; 3087818; 3088041; 3090045; 3090401; 3103680; 3126346; 3133640; 3161893; 3896853; 6089198; 6337343; 6433976; 6538514; 6538515; 6572897; 6682760; 7582899; 7586269; 7721771; 7876253; 8360181; 8366113; 8508955; 8533091; 8607113; 8613982; 9268299; 9305622; 9359841; 9434908; 9988531; 10340997; 10543954; 10632583; 10956663; 11170397; 11371191; 11384978; 11385207; 11450845; 11507973; 11734662; 11734664; 11816707; 11848437; 11858184; 11864703; 11864708; 11928812; 11928826; 11963567; 11978811; 11986218; 11988309; 12023848; 12090757; 12123488; 12167592; 12228252; 12354288; 12390834; 12445472; 12468550; 12468767; 12477932; 12484521; 12524082; 12544724; 12544772; 12589088; 12643326; 12694198; 12719777; 12719778; 12726991; 12727218; 12794725; 12891381; 12913003; 12941043; 14500731; 14529669; 14592829; 14608053; 14630788; 14697941; 14746139; 14759258; 14983221; 15016824; 15031453; 15080889; 15109703; 15116264; 15119966; 15140132; 15207811; 15269833; 15448144; 15466927; 15489334; 15541709; 15542697; 15550028; 15629242; 15652516; 15721275; 15846799; 15861134; 15869598; 15916851; 15976969; 16015279; 16037259; 16113755; 16179568; 16248996; 16320350; 16344560; 16356191; 16369808; 16385091; 16410064; 16466010; 16614319; 16706993; 16733850; 16828203; 16836660; 16839347; 16879221; 16953275; 17003923; 17064755; 17145060; 17151781; 17207964; 17257155; 17264956; 17287634; 17320454; 17408411; 17419735; 17458906; 17473573; 17608581; 17636064; 17649957; 17661167; 17681507; 17689414; 17934860; 17986506; 18023202; 18029284; 18029348; 18037995; 18057060; 18194423; 18202522; 18289715; 18321860; 18331597; 18419748; 18449420; 18468424; 18472001; 18541262; 18574075; 18629628; 18647223; 18662099; 18690354; 18714030; 18720901; 18818748; 18922856; 18945481; 18953568; 1…
description: plasminogen activator, tissue
database cross reference: Ensembl:ENSG00000104368
database cross reference: HGNC:9051
database cross reference: HPRD:01419
database cross reference: MIM:173370
database cross reference: Vega:OTTHUMG00000164072

PLAU
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ATF
alternative term: BDPLT5
alternative term: QPD
alternative term: UPA
alternative term: URK
alternative term: u-PA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PLAU
full name from nomenclature authority: plasminogen activator, urokinase
NCBI GeneID: 5328
NCBI LocusTag: RP11-417O11.1
gene map location: 10q22.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001666 (EC: IEA); GO_0004252 (EC: TAS); GO_0005515 (EC: IPI, PMID: 10340997); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 18835034); GO_0005886 (EC: TAS); GO_0006508 (EC: TAS, PMID: 6589620); GO_0006935 (EC: TAS, PMID: 10749881); GO_0007165 (EC: TAS, PMID: 10749881); GO_0007596 (EC: TAS); GO_0009986 (EC: IDA, PMID: 18835034); GO_0010469 (EC: IDA, PMID: 8837777); GO_0014909 (EC: IEA); GO_0014910 (EC: IDA, PMID: 8837777); GO_0033628 (EC: IDA, PMID: 8837777); GO_0042127 (EC: IEA); GO_0042730 (EC: TAS); GO_0061041 (EC: IC, PMID: 8837777); GO_2000097 (EC: IDA, PMID: 8837777)
has PubMed association: PMID: 134998; 1327118; 1334458; 1499567; 1551416; 1900515; 2023947; 2161846; 2166055; 2415429; 2536903; 2544876; 2551064; 2752144; 2829380; 2987867; 3023326; 3031025; 3090045; 3501295; 3840278; 3888571; 3920216; 3933505; 4226004; 6589620; 6749491; 6754569; 6754572; 7548163; 7559792; 7592875; 7721771; 7867716; 8033079; 8107091; 8227186; 8270642; 8344937; 8388810; 8428004; 8591045; 8652631; 8676469; 8837777; 8895530; 9065988; 9143604; 9151681; 9184208; 9194591; 9365930; 9516128; 9566979; 9680361; 9766559; 9824347; 10221568; 10340997; 10361124; 10362070; 10402467; 10505055; 10636902; 10749881; 10788498; 10805774; 10962009; 10996659; 11023511; 11266465; 11384978; 11394884; 11501527; 11751384; 11805108; 11827968; 11858184; 11876553; 11880102; 11906036; 11928806; 11928807; 11928809; 11928812; 11928816; 11928818; 11930938; 11956327; 12008951; 12023847; 12041678; 12084931; 12115506; 12149463; 12152683; 12161038; 12167592; 12174885; 12183060; 12218297; 12236587; 12353084; 12377770; 12393547; 12430175; 12477728; 12477932; 12529357; 12556966; 12574820; 12576295; 12642587; 12684636; 12704669; 12708473; 12719778; 12719789; 12736046; 12743986; 12754271; 12764090; 12771144; 12773490; 12832381; 12881310; 12883725; 12898287; 12926141; 12930304; 12941043; 12960238; 14507113; 14517288; 14531820; 14534291; 14597629; 14644829; 14681909; 14696115; 14704150; 14744782; 14747469; 14769799; 14982725; 14983219; 14983227; 15067375; 15083890; 15149885; 15210852; 15217951; 15231498; 15243126; 15262029; 15326109; 15356878; 15371454; 15375521; 15489334; 15494526; 15515049; 15558716; 15615772; 15616835; 15629242; 15646834; 15653692; 15728176; 15750768; 15831288; 15849510; 15854129; 15868845; 15880258; 15881651; 15885322; 15886816; 15927351; 15937335; 15944400; 15988036; 15996887; 16008557; 16077991; 16102112; 16113755; 16127174; 16236890; 16267271; 16385451; 16456079; 16459332; 16461772; 16504015; 16509805; 16525631; 16547007; 16601839; 16604464; 16632475; 16685436; 16685447; 16728704; 16761300; 16…
description: plasminogen activator, urokinase
database cross reference: Ensembl:ENSG00000122861
database cross reference: HGNC:9052
database cross reference: HPRD:01883
database cross reference: MIM:191840
database cross reference: Vega:OTTHUMG00000018494

PLG
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PLG
full name from nomenclature authority: plasminogen
NCBI GeneID: 5340
NCBI LocusTag: RP1-81D8.1
gene map location: 6q26
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002576 (EC: TAS); GO_0004252 (EC: IDA, PMID: 14699093); GO_0005515 (EC: IPI, PMID: 10077593); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 6216475); GO_0005886 (EC: TAS); GO_0007596 (EC: IMP, PMID: 1986355); GO_0007596 (EC: TAS); GO_0008285 (EC: TAS, PMID: 8910613); GO_0009986 (EC: IDA, PMID: 14699093); GO_0010812 (EC: IDA, PMID: 14699093); GO_0019904 (EC: IPI, PMID: 9786936); GO_0022617 (EC: IDA, PMID: 14699093); GO_0022617 (EC: TAS); GO_0030168 (EC: TAS); GO_0030198 (EC: TAS); GO_0031093 (EC: TAS); GO_0031232 (EC: IDA, PMID: 14699093); GO_0034185 (EC: IPI, PMID: 16480936); GO_0042246 (EC: IEA); GO_0042730 (EC: TAS); GO_0044267 (EC: TAS); GO_0045445 (EC: IEA); GO_0046716 (EC: IEA); GO_0048771 (EC: IEA); GO_0051603 (EC: IEA); GO_0051918 (EC: IDA, PMID: 14726399); GO_0051919 (EC: IDA, PMID: 6438154); GO_0060707 (EC: IEA); GO_0060716 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19199708); GO_0071674 (EC: IEA); GO_0072562 (EC: IDA); GO_2000048 (EC: TAS, PMID: 17203182)
has PubMed association: PMID: 122932; 126863; 134998; 142009; 146197; 158022; 479158; 659588; 1427790; 1657148; 1657149; 1909331; 1939207; 1986355; 2065054; 2157850; 2318848; 2437112; 2522013; 2745554; 2829380; 2962191; 2962641; 3030813; 3334852; 3356193; 3920216; 4226004; 4240117; 4694729; 5475635; 6094526; 6148961; 6216475; 6238949; 6438154; 6582496; 6838832; 6919539; 6980881; 7525077; 7538844; 7548163; 7586586; 7814888; 7982919; 8054447; 8162705; 8181475; 8181476; 8360181; 8392398; 8460120; 8478593; 8555184; 8611560; 8612605; 8652577; 8843739; 8910613; 9020112; 9054441; 9102221; 9102401; 9201958; 9234243; 9242524; 9305949; 9337997; 9360944; 9375744; 9428707; 9490681; 9521645; 9548733; 9596664; 9688635; 9737862; 9783753; 9786936; 9834305; 9858247; 10069369; 10077593; 10215610; 10218588; 10233898; 10512713; 10604721; 10625689; 10656799; 10700393; 10889192; 10928473; 10956663; 10964919; 10974350; 10978167; 11027681; 11100730; 11113116; 11169399; 11257124; 11263499; 11342539; 11350170; 11371191; 11438139; 11729324; 11888684; 11928826; 11939791; 12016220; 12036889; 12054798; 12080056; 12093796; 12189145; 12192005; 12228252; 12406896; 12456874; 12477932; 12604689; 12646571; 12692411; 12697748; 12700073; 12736244; 12871329; 12876630; 14574404; 14678821; 14699093; 14719094; 14726399; 14739127; 14739293; 14764098; 14769799; 15090462; 15099286; 15207811; 15211511; 15215240; 15220341; 15299951; 15321992; 15333838; 15489334; 15501816; 15529749; 15609351; 15613921; 15642732; 15677446; 15746964; 15911629; 16043488; 16087677; 16097950; 16229836; 16319056; 16478887; 16480936; 16601838; 16790522; 16828203; 17115186; 17200769; 17203182; 17206383; 17272502; 17379720; 17545513; 17606760; 17616171; 17653767; 17656680; 17890952; 17927806; 17976375; 17978577; 18039838; 18070889; 18160581; 18163891; 18223261; 18279394; 18289715; 18310038; 18329389; 18331597; 18366077; 18392331; 18566672; 18568768; 18624398; 18658146; 18667578; 18685433; 18714035; 18981180; 18983515; 19074676; 19158842; 19199708; 19308255; 1936…
description: plasminogen

PLP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GPM6C
alternative term: HLD1
alternative term: MMPL
alternative term: PLP
alternative term: PLP/DM20
alternative term: PMD
alternative term: SPG2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PLP1
full name from nomenclature authority: proteolipid protein 1
NCBI GeneID: 5354
NCBI LocusTag: GHc-698D2.1
gene map location: Xq22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005198 (EC: TAS, PMID: 2479017); GO_0005886 (EC: IDA); GO_0007229 (EC: IEA); GO_0007268 (EC: TAS, PMID: 2479017); GO_0008219 (EC: IEA); GO_0008366 (EC: TAS, PMID: 2479017); GO_0010628 (EC: IEA); GO_0016021 (EC: IEA); GO_0019911 (EC: IEA); GO_0021762 (EC: IEP); GO_0022010 (EC: IEA); GO_0042759 (EC: IEA); GO_0043209 (EC: IEA); GO_0048469 (EC: IEA)
has PubMed association: PMID: 1376966; 1384324; 1707231; 1708672; 1711121; 1715570; 2441695; 2449536; 2467009; 2479017; 2480601; 2773936; 3457761; 3467339; 3768366; 3840606; 4041237; 6083474; 6201756; 7522741; 7531827; 7539213; 7541731; 7573159; 7679906; 7683951; 7684886; 7684945; 8012387; 8696336; 8765335; 8780101; 8909455; 8956049; 9008538; 9143933; 9247276; 9489796; 9633722; 9728768; 9747038; 9788732; 9858696; 9894878; 9934976; 10203813; 10319897; 10417279; 10520936; 10767322; 11093273; 11872612; 12107410; 12196561; 12237860; 12297985; 12325077; 12477932; 12491939; 12601703; 12805210; 14572140; 14702039; 15009677; 15450775; 15489334; 15627202; 15694262; 15712223; 15753308; 15772651; 15837131; 16130097; 16287154; 16374829; 16380909; 16416265; 16774974; 17171701; 17420921; 17438221; 17500595; 17962415; 18190592; 18437021; 18470932; 18555697; 18604471; 19024090; 19151366; 19244236; 19328639; 19376225; 19396823; 19562355; 19825935; 19955111; 20036320; 20186781; 20301361; 20437587; 20629189; 20885931; 21082496; 21127064; 21177054; 21573057; 21623770; 21679407; 22343157; 22511562; 22695888; 22750001; 22902553; 23142642; 23344956; 24103481; 24519770
description: proteolipid protein 1
database cross reference: Ensembl:ENSG00000123560
database cross reference: HGNC:9086
database cross reference: HPRD:02321
database cross reference: MIM:300401
database cross reference: Vega:OTTHUMG00000022111

POLB
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: POLB
full name from nomenclature authority: polymerase (DNA directed), beta
NCBI GeneID: 5423
gene map location: 8p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003684 (EC: IEA); GO_0003887 (EC: IDA, PMID: 16600869); GO_0005515 (EC: IPI, PMID: 15520167); GO_0005634 (EC: IDA, PMID: 19713937); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA, PMID: 15725623); GO_0005874 (EC: IDA, PMID: 15725623); GO_0005876 (EC: IDA, PMID: 15725623); GO_0006261 (EC: TAS, PMID: 8168825); GO_0006281 (EC: TAS); GO_0006284 (EC: IDA, PMID: 16600869); GO_0006284 (EC: IMP); GO_0006284 (EC: TAS); GO_0006287 (EC: IEA); GO_0006290 (EC: IEA); GO_0006297 (EC: IMP, Qualifier: NOT); GO_0006974 (EC: IMP); GO_0008017 (EC: IDA, PMID: 15725623); GO_0008630 (EC: IEA); GO_0016829 (EC: IDA, PMID: 16600869); GO_0019899 (EC: IPI, PMID: 16600869); GO_0045471 (EC: IEA); GO_0046872 (EC: IEA); GO_0051402 (EC: IEA); GO_0071897 (EC: IEA)
has PubMed association: PMID: 1408801; 1511447; 2040602; 2423078; 2460824; 3182828; 3284575; 7705833; 7914364; 8125298; 8168825; 8769567; 8841118; 8841119; 8841120; 8889548; 8978692; 9207062; 9287163; 9294209; 9572863; 10559261; 10629618; 11163244; 11242139; 11250913; 11467963; 11756435; 11805079; 11827474; 11912205; 11923315; 11955015; 12063248; 12067997; 12173936; 12196536; 12370169; 12453427; 12477932; 12517346; 12665521; 14506279; 14627836; 14988403; 15107487; 15145936; 15260972; 15314187; 15342556; 15367657; 15489334; 15520167; 15548520; 15561706; 15601998; 15725623; 15731342; 15753095; 15764500; 15963946; 16060670; 16169070; 16188889; 16195237; 16543152; 16600869; 16609022; 17065437; 17127106; 17131038; 17173071; 17176113; 17203305; 17209556; 17230526; 17283177; 17286973; 17321545; 17355977; 17526740; 17855454; 18006695; 18039710; 18161950; 18270339; 18313385; 18471977; 18676680; 18686630; 18937502; 19104052; 19120024; 19147782; 19167932; 19170196; 19237606; 19329428; 19330779; 19336415; 19339270; 19536092; 19625176; 19635489; 19692168; 19713937; 19747104; 19838217; 19842163; 20006562; 20150366; 20226869; 20302655; 20303835; 20403997; 20423048; 20459144; 20465217; 20496165; 20519499; 20522537; 20526335; 20574454; 20805875; 21107011; 21139048; 21305655; 21362556; 21733843; 21739967; 21757740; 21884718; 22070286; 22082156; 22162999; 22341651; 22373917; 22379092; 22573322; 22577134; 22692827; 22799326; 22901161; 23013478; 23098424; 23117284; 23144153; 23144635; 23144716; 23585564; 23602568; 23749489; 23798703; 23827680; 24133209
description: polymerase (DNA directed), beta

POLD1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CDC2
alternative term: CRCS10
alternative term: MDPL
alternative term: POLD
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: POLD1
full name from nomenclature authority: polymerase (DNA directed), delta 1, catalytic subunit
NCBI GeneID: 5424
gene map location: 19q13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000109 (EC: IDA); GO_0000166 (EC: IEA); GO_0000278 (EC: TAS); GO_0000722 (EC: TAS); GO_0000723 (EC: TAS); GO_0000731 (EC: IDA, PMID: 3335506); GO_0000731 (EC: IMP, PMID: 1730053); GO_0003677 (EC: IDA, PMID: 16762037); GO_0003682 (EC: IDA, PMID: 16762037); GO_0003887 (EC: IMP, PMID: 16762037); GO_0005515 (EC: IPI, PMID: 12403614); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0006260 (EC: IMP, PMID: 16762037); GO_0006271 (EC: TAS); GO_0006281 (EC: TAS); GO_0006283 (EC: TAS); GO_0006284 (EC: TAS); GO_0006287 (EC: IDA, PMID: 10559260); GO_0006289 (EC: TAS); GO_0006297 (EC: IC); GO_0006297 (EC: IMP); GO_0006297 (EC: TAS); GO_0007346 (EC: IBA); GO_0008408 (EC: IBA); GO_0009411 (EC: TAS, PMID: 3146346); GO_0016235 (EC: IDA); GO_0019985 (EC: IBA, Qualifier: NOT); GO_0032201 (EC: TAS); GO_0043137 (EC: IBA); GO_0043625 (EC: IBA); GO_0044281 (EC: TAS); GO_0045004 (EC: IBA); GO_0046872 (EC: IEA); GO_0051539 (EC: IEA); GO_0055089 (EC: IMP); GO_0090305 (EC: IBA)
has PubMed association: PMID: 1427831; 1542570; 1722322; 1730053; 2436659; 3146346; 3335506; 7490075; 8889549; 9030545; 9111189; 9286699; 9545286; 9563011; 9620226; 10559260; 10559261; 10608806; 10852724; 11328591; 11473323; 11923315; 12171929; 12220650; 12393188; 12403614; 12477932; 12530964; 12806015; 14767555; 14988403; 15113441; 15489334; 15670210; 15805117; 15995249; 16169070; 16196087; 16226712; 16488880; 16510448; 16543152; 16762037; 16934752; 17203305; 17314511; 17353931; 17474147; 18247557; 18270339; 18676680; 18701435; 19170196; 19237606; 19329428; 19557333; 19625176; 19692168; 19913121; 20070946; 20226869; 20227374; 20496165; 20522537; 20541997; 20574454; 20628086; 20811636; 21044950; 21139048; 21145461; 21252943; 21415862; 21705323; 21890473; 21906983; 21918226; 21963094; 21987572; 22465957; 22505724; 22678362; 22761421; 22863883; 22887995; 22915169; 22939629; 22942285; 23000965; 23251661; 23263490; 23447401; 23528559; 23585564; 23738518; 23770608; 24250222; 24457600; 24509466
description: polymerase (DNA directed), delta 1, catalytic subunit
database cross reference: Ensembl:ENSG00000062822
database cross reference: HGNC:9175
database cross reference: HPRD:08882
database cross reference: MIM:174761
database cross reference: Vega:OTTHUMG00000183037

PPARA
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NR1C1
alternative term: PPAR
alternative term: PPARalpha
alternative term: hPPAR
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PPARA
full name from nomenclature authority: peroxisome proliferator-activated receptor alpha
NCBI GeneID: 5465
NCBI LocusTag: SC22CB-5E3.5
gene map location: 22q13.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IDA, PMID: 12700342); GO_0001103 (EC: IPI, PMID: 19955185); GO_0001666 (EC: IEA); GO_0003677 (EC: TAS, PMID: 10860941); GO_0003700 (EC: IDA, PMID: 19955185); GO_0003700 (EC: ISS); GO_0003707 (EC: IDA, PMID: 19955185); GO_0004879 (EC: IDA, PMID: 12955147); GO_0005515 (EC: IPI, PMID: 11915042); GO_0005634 (EC: TAS, PMID: 16271724); GO_0005654 (EC: TAS); GO_0006367 (EC: TAS); GO_0006629 (EC: TAS, PMID: 7684926); GO_0006631 (EC: IEA); GO_0007507 (EC: IEA); GO_0008144 (EC: IDA, PMID: 12955147); GO_0008270 (EC: IEA); GO_0008289 (EC: IDA, PMID: 12955147); GO_0008544 (EC: IEA); GO_0010467 (EC: TAS); GO_0010745 (EC: IC, PMID: 12700342); GO_0010745 (EC: IDA, PMID: 19114110); GO_0010871 (EC: IDA, PMID: 12700342); GO_0010887 (EC: IDA, PMID: 19114110); GO_0010891 (EC: IDA, PMID: 12700342); GO_0015908 (EC: TAS, PMID: 16271724); GO_0019902 (EC: IEA); GO_0019904 (EC: IEA); GO_0030522 (EC: IDA, PMID: 12955147); GO_0031624 (EC: IPI, PMID: 19955185); GO_0032000 (EC: TAS, PMID: 16271724); GO_0032091 (EC: IEA); GO_0032099 (EC: ISS); GO_0032403 (EC: IEA); GO_0032868 (EC: IEA); GO_0035095 (EC: IEA); GO_0042060 (EC: IEA); GO_0042157 (EC: IEA); GO_0043565 (EC: ISS); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0045776 (EC: IEA); GO_0045820 (EC: IC, PMID: 19955185); GO_0045893 (EC: IDA, PMID: 12955147); GO_0045944 (EC: IDA, PMID: 19955185); GO_0046321 (EC: ISS); GO_0051525 (EC: IEA); GO_0070166 (EC: IEA); GO_0072363 (EC: IDA, PMID: 19955185); GO_0072366 (EC: IDA, PMID: 19955185); GO_0072369 (EC: IDA, PMID: 19955185); GO_0097371 (EC: IEA); GO_1901215 (EC: IEA); GO_2000678 (EC: IEA)
has PubMed association: PMID: 7684926; 7981125; 8621574; 8910358; 8993548; 9113987; 9238002; 9407140; 9610365; 9626662; 9627117; 9653119; 9748221; 9792666; 9795230; 9915808; 10022764; 10187842; 10195690; 10336495; 10377439; 10403814; 10542237; 10591208; 10669761; 10681503; 10731636; 10786636; 10860941; 10862523; 10872826; 10903152; 11119019; 11226238; 11337467; 11375929; 11409711; 11466580; 11587644; 11668221; 11698662; 11733490; 11818483; 11840500; 11845213; 11852057; 11864924; 11891224; 11897617; 11897821; 11914252; 11915042; 11923467; 11934839; 11940516; 11980898; 11981036; 12006394; 12023905; 12039952; 12042669; 12048138; 12055195; 12118000; 12118038; 12161442; 12163133; 12189208; 12203367; 12208475; 12395215; 12408750; 12468272; 12477932; 12482853; 12544508; 12554753; 12562861; 12594295; 12594814; 12615366; 12655356; 12700342; 12709436; 12745064; 12810707; 12835617; 12847522; 12855749; 12897377; 12914524; 12932225; 12938026; 12955147; 12962497; 14515181; 14519597; 14523052; 14633846; 14641801; 14671555; 14677049; 14702039; 14730379; 14764586; 14999402; 15001458; 15001550; 15051727; 15067378; 15083308; 15111510; 15128052; 15131257; 15196699; 15199365; 15221005; 15231516; 15258199; 15309680; 15318936; 15456881; 15461802; 15497675; 15500444; 15521013; 15539630; 15549499; 15608561; 15615782; 15642120; 15677519; 15685545; 15699244; 15699916; 15735069; 15759454; 15797250; 15811118; 15870285; 15888456; 15935279; 15940190; 16042408; 16043164; 16162941; 16169070; 16189514; 16221474; 16226051; 16239970; 16271724; 16275545; 16285997; 16288935; 16288986; 16297361; 16309557; 16377806; 16416313; 16492688; 16506057; 16511589; 16554032; 16630553; 16637234; 16652134; 16763159; 16806233; 16822823; 16847426; 16875506; 16956579; 17001213; 17008383; 17084382; 17129741; 17150915; 17181634; 17184146; 17195188; 17200111; 17244467; 17272748; 17300045; 17317762; 17331954; 17342071; 17355223; 17356846; 17363697; 17363837; 17431031; 17436029; 17492134; 17608096; 17616429; 17646210; 17655842; 17700210; 17705849; …
description: peroxisome proliferator-activated receptor alpha
database cross reference: Ensembl:ENSG00000186951
database cross reference: HGNC:9232
database cross reference: HPRD:01369
database cross reference: MIM:170998
database cross reference: Vega:OTTHUMG00000150443

PPARG
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CIMT1
alternative term: GLM1
alternative term: NR1C3
alternative term: PPARG1
alternative term: PPARG2
alternative term: PPARgamma
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PPARG
full name from nomenclature authority: peroxisome proliferator-activated receptor gamma
NCBI GeneID: 5468
gene map location: 3p25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IDA, PMID: 12700342); GO_0000122 (EC: ISS); GO_0001012 (EC: IEA); GO_0001890 (EC: ISS); GO_0002674 (EC: IEA); GO_0003677 (EC: IDA, PMID: 16239304); GO_0003677 (EC: ISS); GO_0003682 (EC: IEA); GO_0003700 (EC: IDA, PMID: 9568715); GO_0003700 (EC: ISS); GO_0003707 (EC: IEA); GO_0004879 (EC: IDA, PMID: 10622252); GO_0004955 (EC: TAS, PMID: 9568715); GO_0005515 (EC: IPI, PMID: 10428834); GO_0005634 (EC: IDA, PMID: 9568716); GO_0005654 (EC: TAS); GO_0005829 (EC: ISS); GO_0006367 (EC: TAS); GO_0006629 (EC: TAS, PMID: 9568716); GO_0006919 (EC: IDA, PMID: 18293083); GO_0007165 (EC: IDA, PMID: 9568716); GO_0007186 (EC: TAS, PMID: 9568715); GO_0007507 (EC: IEA); GO_0007584 (EC: TAS, PMID: 10973253); GO_0008144 (EC: IDA, PMID: 10622252); GO_0008217 (EC: IMP, PMID: 10622252); GO_0008270 (EC: IEA); GO_0009409 (EC: IEA); GO_0010467 (EC: TAS); GO_0010745 (EC: IC, PMID: 12700342); GO_0010745 (EC: IDA, PMID: 19114110); GO_0010871 (EC: IDA, PMID: 12700342); GO_0010887 (EC: IDA, PMID: 19114110); GO_0010891 (EC: IDA, PMID: 12700342); GO_0015909 (EC: ISS); GO_0019395 (EC: IEA); GO_0019899 (EC: IPI, PMID: 12039952); GO_0030224 (EC: IDA, PMID: 9568716); GO_0030308 (EC: IEA); GO_0030374 (EC: IDA, PMID: 16239304); GO_0030855 (EC: ISS); GO_0031000 (EC: IEA); GO_0031100 (EC: IEA); GO_0032526 (EC: IDA, PMID: 16239304); GO_0032869 (EC: IMP, PMID: 10622252); GO_0033189 (EC: IEA); GO_0033613 (EC: IDA, PMID: 10622252); GO_0033993 (EC: ISS, PMID: 9568715); GO_0035357 (EC: IMP); GO_0042493 (EC: IEA); GO_0042593 (EC: IMP, PMID: 10622252); GO_0042953 (EC: IDA, PMID: 9568716); GO_0043565 (EC: IDA, Qualifier: contributes_to, PMID: 9568716); GO_0043627 (EC: IEA); GO_0044212 (EC: IDA, PMID: 18293083); GO_0044212 (EC: ISS); GO_0045087 (EC: TAS, PMID: 17145956); GO_0045165 (EC: ISS); GO_0045600 (EC: ISS); GO_0045713 (EC: IDA, PMID: 9568716); GO_0045892 (EC: ISS); GO_0045893 (EC: ISS); GO_0045944 (EC: IDA, PMID: 12700342); GO_0045944 (EC: IMP); GO_0046321 (EC: IEA); GO_0046965 (EC: IDA, PMID: …
has PubMed association: PMID: 1504714; 7787419; 7838715; 8001151; 8125298; 8702406; 9030579; 9041124; 9065481; 9113987; 9121466; 9144532; 9168928; 9228052; 9325263; 9356045; 9568715; 9568716; 9626662; 9653119; 9744270; 9750197; 9753710; 9813012; 9918859; 10037764; 10075656; 10339548; 10347167; 10394368; 10407229; 10428834; 10428835; 10517671; 10558993; 10622252; 10681503; 10731636; 10781090; 10788465; 10842190; 10843155; 10848596; 10854698; 10872826; 10882139; 10930400; 10935544; 10973253; 10974018; 11027271; 11069206; 11079814; 11226238; 11242476; 11246892; 11248748; 11289055; 11315829; 11330046; 11334419; 11402923; 11409297; 11443177; 11444435; 11466580; 11500849; 11508283; 11511919; 11522688; 11554739; 11554760; 11587644; 11596673; 11696534; 11698662; 11788685; 11792840; 11793024; 11809750; 11831892; 11836319; 11836575; 11840500; 11845236; 11847231; 11862322; 11872365; 11872366; 11872377; 11872694; 11877444; 11884452; 11888683; 11891224; 11897617; 11897821; 11903058; 11914642; 11916624; 11923467; 11924722; 11928067; 11934839; 11948400; 11948965; 11953889; 11956653; 11971969; 11972302; 11979403; 11980626; 11980898; 12015306; 12029076; 12037571; 12039952; 12040021; 12048686; 12054675; 12055328; 12056809; 12062858; 12065695; 12075579; 12077117; 12079854; 12080321; 12080444; 12082592; 12086968; 12107164; 12118251; 12145143; 12145174; 12145184; 12148087; 12161538; 12161548; 12165097; 12189136; 12193733; 12213872; 12218380; 12230498; 12324185; 12324573; 12354130; 12370112; 12395215; 12397176; 12397391; 12401439; 12404189; 12406034; 12429071; 12439219; 12453902; 12453919; 12457461; 12468551; 12477932; 12479814; 12485829; 12502512; 12502716; 12519876; 12535639; 12536206; 12538445; 12544508; 12551936; 12565902; 12568179; 12588773; 12588810; 12591919; 12594295; 12601634; 12601635; 12609711; 12610044; 12615657; 12615696; 12615821; 12620489; 12630956; 12663371; 12672231; 12673785; 12679463; 12700342; 12709137; 12714563; 12714582; 12716762; 12727991; 12730300; 12730867; 12732844; 12739018; 12746759;…
description: peroxisome proliferator-activated receptor gamma
database cross reference: Ensembl:ENSG00000132170
database cross reference: HGNC:9236
database cross reference: HPRD:03288
database cross reference: MIM:601487
database cross reference: Vega:OTTHUMG00000129764

PPP2CA
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PP2Ac
alternative term: PP2CA
alternative term: PP2Calpha
alternative term: RP-C
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PPP2CA
full name from nomenclature authority: protein phosphatase 2, catalytic subunit, alpha isozyme
NCBI GeneID: 5515
gene map location: 5q31.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000159 (EC: IDA, PMID: 17055435); GO_0000159 (EC: TAS, PMID: 11007961); GO_0000184 (EC: TAS); GO_0000188 (EC: NAS, PMID: 11007961); GO_0000278 (EC: TAS); GO_0000775 (EC: IEA); GO_0000922 (EC: IEA); GO_0004722 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11591705); GO_0005634 (EC: NAS, PMID: 11007961); GO_0005739 (EC: NAS, PMID: 11007961); GO_0005829 (EC: TAS, PMID: 11007961); GO_0005886 (EC: IEA); GO_0006275 (EC: NAS, PMID: 11007961); GO_0006355 (EC: NAS, PMID: 11007961); GO_0006470 (EC: TAS, PMID: 11007961); GO_0006672 (EC: NAS, PMID: 11007961); GO_0006915 (EC: TAS, PMID: 11007961); GO_0007084 (EC: TAS); GO_0007126 (EC: IEA); GO_0007498 (EC: IEA); GO_0008022 (EC: IEA); GO_0008380 (EC: NAS, PMID: 11007961); GO_0008543 (EC: TAS); GO_0010033 (EC: NAS, PMID: 11007961); GO_0010467 (EC: TAS); GO_0010469 (EC: IEA); GO_0010719 (EC: IMP); GO_0015630 (EC: NAS, PMID: 11007961); GO_0016020 (EC: NAS, PMID: 11007961); GO_0016070 (EC: TAS); GO_0016071 (EC: TAS); GO_0019932 (EC: NAS, PMID: 11007961); GO_0030111 (EC: NAS, PMID: 11007961); GO_0030155 (EC: NAS, PMID: 11007961); GO_0030308 (EC: NAS, PMID: 11007961); GO_0031952 (EC: IEA); GO_0040008 (EC: NAS, PMID: 11360189); GO_0042176 (EC: IEA); GO_0042518 (EC: NAS, PMID: 11007961); GO_0045595 (EC: NAS, PMID: 11360189); GO_0046872 (EC: IEA); GO_0046983 (EC: IEA); GO_0070062 (EC: IDA); GO_0070208 (EC: IEA); GO_0071902 (EC: IMP)
has PubMed association: PMID: 1328247; 1330687; 1846293; 1848320; 1848668; 2555176; 2557326; 2837763; 2849764; 4092695; 7592815; 8206937; 8262976; 8383590; 8386634; 8392375; 8524402; 8617797; 8617805; 8703017; 9003791; 9009195; 9013886; 9353299; 9400615; 9647778; 9795170; 9847399; 9852076; 9920888; 9989501; 10191253; 10200280; 10357815; 10441131; 10629059; 10644691; 10675325; 10681496; 10698523; 10769027; 10934208; 11007961; 11113010; 11114196; 11259605; 11278485; 11313937; 11360189; 11371618; 11438723; 11440634; 11531413; 11591705; 11842093; 11929874; 11929880; 11956189; 11959144; 11983168; 12036313; 12036952; 12054646; 12058047; 12062430; 12186863; 12370081; 12435421; 12477932; 12514180; 12556559; 12624094; 12637511; 12842894; 12859198; 12912990; 12915404; 14633983; 14645548; 14702039; 14724252; 15147202; 15231747; 15247211; 15252037; 15380617; 15489334; 15671020; 15761153; 15761952; 16041367; 16085932; 16109716; 16126728; 16169070; 16189514; 16191191; 16258073; 16306228; 16341674; 16456541; 16541025; 16580887; 16596250; 16764867; 17055435; 17110338; 17148452; 17163575; 17174897; 17245430; 17255109; 17266553; 17297438; 17374643; 17485487; 17540176; 17632056; 17693927; 17803990; 17852432; 17855368; 17941990; 17974561; 18160256; 18191226; 18299321; 18339811; 18430997; 18477699; 18583989; 18586681; 18715871; 18768864; 18782753; 18852266; 18928587; 18949047; 18971272; 18977201; 19060904; 19126401; 19131971; 19155497; 19156129; 19356149; 19360341; 19553685; 19738201; 19818709; 20065038; 20092282; 20100830; 20106966; 20133759; 20133760; 20360068; 20363734; 20448038; 20544796; 20558158; 20562864; 20615878; 20639865; 20663872; 20677014; 20711181; 20811636; 21072166; 21081666; 21139048; 21145461; 21151953; 21172653; 21346232; 21351466; 21355954; 21393425; 21454489; 21590681; 21708940; 21791414; 21835928; 21890473; 21906983; 21959857; 21963094; 21983900; 21987572; 21988832; 21996587; 22031698; 22053931; 22065577; 22135143; 22167190; 22192750; 22299668; 22314363; 22379092; 22422068; 22443683; 22466…
description: protein phosphatase 2, catalytic subunit, alpha isozyme
database cross reference: HGNC:9299
database cross reference: HPRD:08912
database cross reference: MIM:176915

PRIM1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: p49
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PRIM1
full name from nomenclature authority: primase, DNA, polypeptide 1 (49kDa)
NCBI GeneID: 5557
gene map location: 12q13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000082 (EC: TAS); GO_0000278 (EC: TAS); GO_0000722 (EC: TAS); GO_0000723 (EC: TAS); GO_0003896 (EC: IEA); GO_0005654 (EC: TAS); GO_0006269 (EC: TAS, PMID: 8026492); GO_0006270 (EC: TAS); GO_0006271 (EC: TAS); GO_0032201 (EC: TAS); GO_0046872 (EC: IEA); GO_1990077 (EC: IEA)
has PubMed association: PMID: 6693436; 8026492; 8125298; 8530050; 9268648; 9705292; 9822671; 10441007; 10504261; 11473323; 11917009; 12393188; 12477932; 15489334; 16169070; 17035231; 19615732; 20030400; 21139048; 21145461; 21890473; 21906983; 21963094; 22267201; 22505724; 22593576; 22678362; 22939629; 22990118; 23000965
description: primase, DNA, polypeptide 1 (49kDa)
database cross reference: Ensembl:ENSG00000198056
database cross reference: HGNC:9369
database cross reference: HPRD:08899
database cross reference: MIM:176635
database cross reference: Vega:OTTHUMG00000170034

PRKAA2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AMPK
alternative term: AMPK2
alternative term: AMPKa2
alternative term: PRKAA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PRKAA2
full name from nomenclature authority: protein kinase, AMP-activated, alpha 2 catalytic subunit
NCBI GeneID: 5563
gene map location: 1p31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003682 (EC: ISS); GO_0004672 (EC: TAS, PMID: 7959015); GO_0004674 (EC: ISS); GO_0004679 (EC: IDA, PMID: 18439900); GO_0005515 (EC: IPI, PMID: 18439900); GO_0005524 (EC: IEA); GO_0005654 (EC: TAS); GO_0005829 (EC: TAS); GO_0006112 (EC: TAS); GO_0006351 (EC: IEA); GO_0006355 (EC: IEA); GO_0006468 (EC: TAS, PMID: 7959015); GO_0006633 (EC: IEA); GO_0006695 (EC: IEA); GO_0006853 (EC: TAS); GO_0006914 (EC: IEA); GO_0006950 (EC: ISS); GO_0007050 (EC: TAS); GO_0007165 (EC: TAS, PMID: 7959015); GO_0008286 (EC: TAS); GO_0008610 (EC: ISS); GO_0010508 (EC: ISS); GO_0016055 (EC: IEA); GO_0031669 (EC: ISS); GO_0032007 (EC: ISS); GO_0035174 (EC: ISS); GO_0042149 (EC: ISS); GO_0042304 (EC: TAS); GO_0042593 (EC: ISS); GO_0042752 (EC: ISS); GO_0043066 (EC: ISS); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0045821 (EC: ISS); GO_0046872 (EC: IEA); GO_0047322 (EC: IEA); GO_0048511 (EC: IEA); GO_0050405 (EC: IEA); GO_0055089 (EC: ISS); GO_0061024 (EC: TAS); GO_2000505 (EC: ISS)
has PubMed association: PMID: 1322130; 1365882; 1536860; 2900138; 7959015; 7988703; 8889548; 9148944; 9224708; 10642499; 10698692; 10760274; 11052978; 11171059; 11257506; 11389854; 11500364; 11797013; 12067722; 12091379; 12391032; 12413941; 12427743; 12444247; 12456889; 12477932; 12511592; 12519745; 12663462; 12740371; 12788940; 12847291; 12853467; 12941758; 14532170; 14613924; 14651849; 14709557; 14729328; 14742438; 14985344; 14985505; 15024086; 15058305; 15060529; 15231718; 15297373; 15371448; 15489334; 15572372; 15640157; 16054041; 16054095; 16054096; 16275868; 16344560; 16483872; 16505254; 16518831; 16567511; 16598851; 16624523; 16670154; 16710414; 16801347; 16984726; 17179156; 17950019; 18029386; 18195011; 18439900; 18614941; 18674809; 18801964; 18836454; 18974883; 18996102; 19170765; 19434633; 19440859; 19470831; 19502591; 19528236; 19574280; 19616115; 19720090; 19720831; 19723084; 19728147; 19836452; 19913121; 19948975; 20124121; 20167927; 20217115; 20392842; 20558612; 20562859; 20602615; 20628086; 20647423; 20682687; 20821366; 20876741; 21139048; 21209024; 21344388; 21432774; 21543851; 21651489; 21673972; 21825219; 21963094; 22137581; 22212710; 22286170; 22305490; 22728651; 22897928; 22939624; 23000302; 23293026; 23396962; 23476055; 23723070
description: protein kinase, AMP-activated, alpha 2 catalytic subunit
database cross reference: Ensembl:ENSG00000162409
database cross reference: HGNC:9377
database cross reference: HPRD:02735
database cross reference: MIM:600497
database cross reference: Vega:OTTHUMG00000008282

PRKG1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: 1
alternative term: AAT8
alternative term: PKG
alternative term: PRKG1B
alternative term: PRKGR1B
alternative term: cGK
alternative term: cGK 1
alternative term: cGK1
alternative term: cGKI
alternative term: cGKI-BETA
alternative term: cGKI-alpha
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PRKG1
full name from nomenclature authority: protein kinase, cGMP-dependent, type I
NCBI GeneID: 5592
NCBI LocusTag: RP11-346D6.1
gene map location: 10q11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001764 (EC: IEA); GO_0004692 (EC: IDA); GO_0005246 (EC: IDA); GO_0005515 (EC: IPI, PMID: 14608379); GO_0005524 (EC: IEA); GO_0005737 (EC: IDA); GO_0005794 (EC: IEA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 16990611); GO_0006468 (EC: TAS, PMID: 10851246); GO_0007165 (EC: IEA); GO_0007596 (EC: TAS); GO_0016358 (EC: IEA); GO_0030036 (EC: TAS, PMID: 10851246); GO_0030553 (EC: IEA); GO_0030900 (EC: IEA); GO_0043087 (EC: IMP, PMID: 14608379); GO_0090331 (EC: IMP, PMID: 16990611)
has PubMed association: PMID: 1377674; 1544322; 2168396; 2792381; 7589584; 8132598; 8182057; 8380342; 8613202; 8663267; 8688081; 9192852; 9308888; 9687510; 9829964; 10051666; 10449420; 10567269; 10601315; 10671526; 10681529; 10724174; 10851246; 10922374; 11175347; 11278298; 11278415; 11309393; 11884369; 12082086; 12082111; 12119292; 12175859; 12237340; 12477932; 12480535; 12571245; 12574812; 12609995; 12855709; 12933804; 14530262; 14532276; 14608379; 14679200; 14702039; 14983059; 15051728; 15107017; 15164054; 15192100; 15280395; 15489334; 15556942; 15632203; 15711749; 15851553; 15917860; 16131665; 16166082; 16249377; 16331690; 16344560; 16385451; 16407222; 16632465; 16990611; 17601797; 17904578; 17975119; 18029348; 18194177; 18496125; 18519826; 18593937; 18617565; 18757735; 18782776; 18945831; 18983522; 19023099; 19023132; 19424179; 19487814; 19656393; 19851296; 19913121; 19961855; 19996273; 20006992; 20043968; 20068229; 20182759; 20198315; 20348951; 20371672; 20379614; 20567233; 20600009; 20628086; 20732627; 20826808; 21160032; 21402151; 21414799; 21451103; 21479273; 21526164; 21563174; 21697861; 21907864; 22095901; 22293199; 22580283; 22791569; 22806632; 23066013; 23195829; 23251661; 23382691; 23416533; 23418348; 23686857; 23770744; 23793025; 23814119; 23831687; 23876037; 23910461; 24060892; 24060898; 24163370
description: protein kinase, cGMP-dependent, type I
database cross reference: Ensembl:ENSG00000185532
database cross reference: HGNC:9414
database cross reference: HPRD:08910
database cross reference: MIM:176894
database cross reference: Vega:OTTHUMG00000018248

MAPK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ERK
alternative term: ERK-2
alternative term: ERK2
alternative term: ERT1
alternative term: MAPK2
alternative term: P42MAPK
alternative term: PRKM1
alternative term: PRKM2
alternative term: p38
alternative term: p40
alternative term: p41
alternative term: p41mapk
alternative term: p42-MAPK
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAPK1
full name from nomenclature authority: mitogen-activated protein kinase 1
NCBI GeneID: 5594
gene map location: 22q11.21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: TAS); GO_0000186 (EC: TAS); GO_0000187 (EC: TAS); GO_0000189 (EC: IEA); GO_0001784 (EC: IEA); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0003677 (EC: IEA); GO_0004674 (EC: IDA, PMID: 15850461); GO_0004707 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10415025); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005634 (EC: TAS, PMID: 19565474); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA, PMID: 18794356); GO_0005737 (EC: ISS); GO_0005739 (EC: TAS, PMID: 19565474); GO_0005769 (EC: TAS, PMID: 19565474); GO_0005770 (EC: TAS, PMID: 19565474); GO_0005794 (EC: TAS, PMID: 19565474); GO_0005815 (EC: IEA); GO_0005829 (EC: TAS, PMID: 19565474); GO_0005856 (EC: TAS, PMID: 19565474); GO_0005901 (EC: TAS, PMID: 19565474); GO_0005925 (EC: TAS, PMID: 19565474); GO_0006351 (EC: IEA); GO_0006915 (EC: IEA); GO_0006935 (EC: TAS, PMID: 10706854); GO_0006950 (EC: TAS, PMID: 10958679); GO_0006974 (EC: IEA); GO_0007049 (EC: IEA); GO_0007165 (EC: TAS, PMID: 1540184); GO_0007173 (EC: TAS); GO_0007264 (EC: TAS); GO_0007265 (EC: TAS); GO_0007268 (EC: TAS); GO_0007411 (EC: TAS); GO_0007596 (EC: TAS); GO_0008134 (EC: IEA); GO_0008284 (EC: IEA); GO_0008286 (EC: TAS); GO_0008353 (EC: ISS); GO_0008543 (EC: TAS); GO_0009636 (EC: IEA); GO_0009887 (EC: IEA); GO_0010800 (EC: IDA, PMID: 16314496); GO_0015630 (EC: IDA); GO_0016032 (EC: IEA); GO_0018105 (EC: IDA, PMID: 15850461); GO_0018107 (EC: ISS); GO_0019233 (EC: IEA); GO_0019858 (EC: IEA); GO_0019902 (EC: IPI, PMID: 19494114); GO_0030168 (EC: TAS); GO_0030335 (EC: IEA); GO_0031143 (EC: IEA); GO_0031435 (EC: IEA); GO_0031647 (EC: ISS); GO_0031663 (EC: IEA); GO_0032839 (EC: IEA); GO_0032872 (EC: TAS, PMID: 19565474); GO_0033598 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035666 (EC: TAS); GO_0038095 (EC: TAS); GO_0038096 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_003812…
has PubMed association: PMID: 1319925; 1330687; 1347949; 1378617; 1540184; 1648701; 1712480; 2032290; 7535768; 7566346; 7569900; 7737129; 7768935; 7777512; 7816602; 7876160; 7957875; 8083223; 8157000; 8208531; 8221888; 8248197; 8290275; 8381049; 8384717; 8386592; 8388392; 8389479; 8407983; 8506364; 8552640; 8586671; 8607977; 8618896; 8626561; 8626571; 8631994; 8639570; 8794306; 8806671; 8816480; 8846788; 8900182; 8939914; 8960373; 8994038; 9013873; 9029147; 9030579; 9045910; 9069267; 9092573; 9130707; 9155017; 9199329; 9199504; 9207092; 9211903; 9223324; 9325171; 9335504; 9343414; 9388255; 9403476; 9405468; 9430688; 9440696; 9453574; 9528769; 9535905; 9535909; 9535927; 9558095; 9564043; 9565682; 9592082; 9604935; 9621077; 9628874; 9632734; 9649500; 9658081; 9687510; 9725910; 9744883; 9771888; 9788880; 9792705; 9832145; 9857190; 9858547; 9872331; 9915826; 9973222; 10027715; 10051431; 10066798; 10074203; 10187842; 10194762; 10197981; 10206983; 10207078; 10224087; 10230405; 10318905; 10330152; 10347142; 10371216; 10388555; 10405182; 10409742; 10415025; 10419510; 10446219; 10490027; 10509564; 10521505; 10567572; 10581001; 10617468; 10627507; 10635328; 10644696; 10660621; 10692442; 10702794; 10706702; 10706854; 10712923; 10733581; 10737616; 10747973; 10748182; 10757792; 10762698; 10779345; 10780709; 10799874; 10801826; 10866661; 10878576; 10910078; 10915800; 10942774; 10958679; 10958680; 10958792; 10969079; 10982368; 10988299; 10993892; 10996427; 11013076; 11035004; 11044099; 11114188; 11134045; 11153078; 11157753; 11181841; 11205744; 11226163; 11226259; 11258664; 11260070; 11266467; 11278335; 11278395; 11278799; 11279118; 11279232; 11279280; 11313464; 11350735; 11350938; 11352917; 11358671; 11403955; 11408587; 11409852; 11409876; 11409918; 11416124; 11431474; 11481231; 11489891; 11493009; 11500490; 11504923; 11520933; 11532249; 11549292; 11570821; 11579140; 11581251; 11583024; 11585926; 11606045; 11702783; 11726657; 11741541; 11741894; 11744690; 11748628; 11756441; 11773377; 11776327; 11781324…
description: mitogen-activated protein kinase 1
database cross reference: Ensembl:ENSG00000100030
database cross reference: HGNC:6871
database cross reference: HPRD:01496
database cross reference: MIM:176948
database cross reference: Vega:OTTHUMG00000030508

MAPK3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ERK-1
alternative term: ERK1
alternative term: ERT2
alternative term: HS44KDAP
alternative term: HUMKER1A
alternative term: P44ERK1
alternative term: P44MAPK
alternative term: PRKM3
alternative term: p44-ERK1
alternative term: p44-MAPK
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAPK3
full name from nomenclature authority: mitogen-activated protein kinase 3
NCBI GeneID: 5595
gene map location: 16p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: NAS); GO_0000165 (EC: TAS); GO_0000186 (EC: TAS); GO_0000187 (EC: TAS); GO_0001784 (EC: IEA); GO_0001934 (EC: IMP, PMID: 19664780); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004707 (EC: IDA, PMID: 8388392); GO_0004707 (EC: NAS, PMID: 7687743); GO_0004707 (EC: TAS); GO_0005515 (EC: IPI, PMID: 10066421); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005634 (EC: TAS, PMID: 19565474); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005739 (EC: TAS, PMID: 19565474); GO_0005769 (EC: TAS, PMID: 19565474); GO_0005770 (EC: TAS, PMID: 19565474); GO_0005794 (EC: TAS, PMID: 19565474); GO_0005829 (EC: TAS, PMID: 19565474); GO_0005856 (EC: TAS, PMID: 19565474); GO_0005901 (EC: TAS, PMID: 19565474); GO_0005925 (EC: TAS, PMID: 19565474); GO_0006360 (EC: TAS); GO_0006361 (EC: TAS); GO_0006468 (EC: IDA, PMID: 7687743); GO_0006915 (EC: IEA); GO_0006975 (EC: IDA, PMID: 17560175); GO_0007049 (EC: IEA); GO_0007173 (EC: TAS); GO_0007264 (EC: TAS); GO_0007265 (EC: TAS); GO_0007411 (EC: TAS); GO_0007596 (EC: TAS); GO_0008286 (EC: TAS); GO_0008543 (EC: TAS); GO_0009887 (EC: IEA); GO_0010467 (EC: TAS); GO_0015630 (EC: IDA); GO_0016032 (EC: IEA); GO_0016310 (EC: IDA, PMID: 15950189); GO_0019221 (EC: TAS); GO_0019233 (EC: IEA); GO_0019902 (EC: IPI, PMID: 19494114); GO_0030168 (EC: TAS); GO_0030509 (EC: IMP, PMID: 19664780); GO_0031143 (EC: IEA); GO_0031663 (EC: IEA); GO_0032872 (EC: TAS, PMID: 19565474); GO_0033129 (EC: IMP); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035066 (EC: IMP); GO_0035666 (EC: TAS); GO_0038083 (EC: IDA, PMID: 8388392); GO_0038095 (EC: TAS); GO_0038096 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0043330 (EC: IEA); GO_0045087 (EC: TAS); GO_0045944 (EC: IMP); GO_0048011 (EC: TAS); GO_0051090 (EC: TAS); GO_0051216 (EC: IEA); GO_0051403 (EC: TAS); GO_0051493 (EC: TAS, PMID: 19565474); GO_0060397 (EC: TAS); GO…
has PubMed association: PMID: 862676; 1319925; 1322499; 1347949; 1463607; 1540184; 1922387; 7535768; 7687743; 7739560; 7836374; 8112321; 8152805; 8197172; 8208531; 8226933; 8290275; 8325880; 8376365; 8388392; 8407983; 8423803; 8506364; 8552640; 8618896; 8626571; 8626767; 8631994; 8632909; 8639570; 8794306; 8806671; 8939914; 8940068; 9006895; 9020136; 9054461; 9069267; 9126608; 9130707; 9155018; 9211903; 9218456; 9223324; 9235954; 9325171; 9343414; 9388255; 9403476; 9446616; 9525956; 9535905; 9535909; 9535927; 9558095; 9564043; 9621077; 9628824; 9658081; 9687510; 9733512; 9792677; 9792705; 9857190; 9872331; 9915826; 10027715; 10066421; 10074203; 10187842; 10194762; 10206983; 10224087; 10339476; 10347142; 10383391; 10402467; 10415025; 10419510; 10431817; 10446219; 10509564; 10521505; 10551817; 10559944; 10570282; 10574913; 10581001; 10597297; 10617468; 10627507; 10635328; 10648599; 10677502; 10702794; 10712923; 10725920; 10727525; 10748187; 10780709; 10799874; 10869359; 10912793; 10915800; 10958792; 10982368; 11027280; 11044099; 11114188; 11131153; 11134045; 11135364; 11205744; 11226163; 11260070; 11278799; 11279232; 11287604; 11342557; 11350938; 11387337; 11403955; 11409852; 11409918; 11466319; 11504923; 11520933; 11532249; 11551945; 11570821; 11579140; 11581251; 11583024; 11585926; 11682603; 11702783; 11741541; 11741977; 11773377; 11776327; 11781324; 11784715; 11788583; 11792123; 11866440; 11866540; 11884401; 11891214; 11904305; 11923300; 11930938; 11937531; 11948414; 11952164; 11960991; 11961297; 11986622; 11988087; 12030372; 12032872; 12048211; 12049732; 12063245; 12081892; 12082090; 12082091; 12089333; 12095152; 12118371; 12121974; 12167619; 12183542; 12193595; 12200131; 12218048; 12226077; 12239168; 12356731; 12362243; 12388423; 12408764; 12441075; 12446729; 12456688; 12473660; 12477932; 12482669; 12491158; 12529294; 12531514; 12538349; 12538595; 12540563; 12555071; 12562867; 12576423; 12594221; 12603851; 12606501; 12624094; 12624098; 12637339; 12637502; 12637525; 12643788; 12663671; 1…
description: mitogen-activated protein kinase 3
database cross reference: Ensembl:ENSG00000102882
database cross reference: HGNC:6877
database cross reference: HPRD:03479
database cross reference: MIM:601795
database cross reference: Vega:OTTHUMG00000132149

MAPK8
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: JNK
alternative term: JNK-46
alternative term: JNK1
alternative term: JNK1A2
alternative term: JNK21B1/2
alternative term: PRKM8
alternative term: SAPK1
alternative term: SAPK1c
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAPK8
full name from nomenclature authority: mitogen-activated protein kinase 8
NCBI GeneID: 5599
gene map location: 10q11.22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001503 (EC: IEA); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004674 (EC: IDA, PMID: 14967141); GO_0004705 (EC: IDA); GO_0005515 (EC: IPI, PMID: 10393177); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005739 (EC: IEA); GO_0005829 (EC: TAS); GO_0006915 (EC: TAS); GO_0006950 (EC: TAS, PMID: 8137421); GO_0007254 (EC: IDA, PMID: 8654373); GO_0007254 (EC: TAS); GO_0007258 (EC: IDA, PMID: 14967141); GO_0009411 (EC: IDA, PMID: 14967141); GO_0010628 (EC: IMP); GO_0018105 (EC: IDA, PMID: 15850461); GO_0018107 (EC: IDA); GO_0018107 (EC: IMP); GO_0031063 (EC: IMP); GO_0032091 (EC: IDA); GO_0032880 (EC: IDA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035033 (EC: IMP); GO_0035666 (EC: TAS); GO_0038095 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042826 (EC: IPI); GO_0043065 (EC: TAS); GO_0043066 (EC: IDA, PMID: 14967141); GO_0045087 (EC: TAS); GO_0046686 (EC: IEA); GO_0048011 (EC: TAS); GO_0051090 (EC: TAS); GO_0051403 (EC: TAS); GO_0071260 (EC: IEP, PMID: 19593445); GO_0090045 (EC: IMP); GO_0097190 (EC: TAS); GO_0097193 (EC: TAS); GO_1900740 (EC: TAS); GO_2000017 (EC: IEA); GO_2001235 (EC: IEA)
has PubMed association: PMID: 1748630; 7535770; 7642542; 7737129; 7737130; 7839144; 8001819; 8137421; 8177321; 8224842; 8586671; 8621542; 8632909; 8654373; 8846788; 8917518; 9020136; 9030579; 9045910; 9129988; 9162092; 9195981; 9199329; 9199504; 9207092; 9211903; 9223324; 9235954; 9343414; 9374537; 9393873; 9396779; 9399639; 9403476; 9405400; 9405416; 9520479; 9575168; 9621077; 9661668; 9670954; 9692890; 9724739; 9732264; 9733513; 9774977; 9788880; 9808624; 9851932; 9872331; 9889198; 10187783; 10346818; 10357815; 10383391; 10391943; 10393177; 10394361; 10419510; 10446219; 10471813; 10490659; 10509564; 10521505; 10523642; 10551811; 10567572; 10585392; 10597297; 10601313; 10629060; 10713157; 10722755; 10747973; 10756100; 10797012; 10799874; 10856240; 10878576; 10912793; 10913135; 10962563; 11042694; 11057897; 11062067; 11108663; 11153078; 11238452; 11260070; 11278395; 11278789; 11278799; 11279118; 11279197; 11279232; 11283254; 11323415; 11350938; 11387337; 11408587; 11432831; 11448159; 11468147; 11479302; 11489891; 11504923; 11517249; 11525649; 11551945; 11566021; 11602244; 11606564; 11698270; 11700324; 11707464; 11749722; 11781324; 11788583; 11865055; 11912216; 11931768; 11944898; 11948398; 11971973; 11983683; 11988087; 12023963; 12039864; 12052834; 12058026; 12058028; 12079429; 12089333; 12095152; 12097334; 12121974; 12135322; 12138158; 12140754; 12143039; 12148599; 12167088; 12171600; 12185592; 12189133; 12206715; 12223491; 12225289; 12228228; 12239168; 12242293; 12296995; 12351658; 12351702; 12354774; 12359245; 12376548; 12391307; 12413764; 12417588; 12421945; 12477932; 12478662; 12514174; 12538493; 12576423; 12591950; 12592382; 12646240; 12646564; 12659851; 12689591; 12697749; 12707267; 12714584; 12734330; 12756254; 12763138; 12775419; 12787561; 12788955; 12804775; 12810082; 12818176; 12821118; 12847227; 12853963; 12857973; 12859962; 12874243; 12878610; 12902351; 12917434; 12958075; 12960231; 12963725; 13130464; 14500675; 14500727; 14504284; 14514687; 14517282; 14532003; 14551213; 14557…
description: mitogen-activated protein kinase 8
database cross reference: Ensembl:ENSG00000107643
database cross reference: HGNC:6881
database cross reference: HPRD:03100
database cross reference: MIM:601158
database cross reference: Vega:OTTHUMG00000018172

MAPK11
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: P38B
alternative term: P38BETA2
alternative term: PRKM11
alternative term: SAPK2
alternative term: SAPK2B
alternative term: p38-2
alternative term: p38Beta
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAPK11
full name from nomenclature authority: mitogen-activated protein kinase 11
NCBI GeneID: 5600
gene map location: 22q13.33
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: TAS); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004674 (EC: TAS); GO_0004707 (EC: IDA, PMID: 10330143); GO_0005515 (EC: IPI, PMID: 17254968); GO_0005524 (EC: IEA); GO_0005654 (EC: TAS); GO_0005829 (EC: TAS); GO_0006351 (EC: IEA); GO_0006950 (EC: IDA, PMID: 8663524); GO_0007165 (EC: TAS, PMID: 8663524); GO_0007265 (EC: TAS); GO_0010467 (EC: TAS); GO_0016070 (EC: TAS); GO_0016071 (EC: TAS); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035556 (EC: IDA, PMID: 8663524); GO_0035666 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042692 (EC: TAS); GO_0045087 (EC: TAS); GO_0048011 (EC: TAS); GO_0051090 (EC: TAS); GO_0051149 (EC: TAS); GO_0051403 (EC: TAS)
has PubMed association: PMID: 8663524; 9029150; 9199504; 9207191; 9218798; 9235954; 9430721; 9628874; 9632706; 9687510; 9832563; 10201954; 10207622; 10330143; 10362531; 10391889; 10591208; 10608813; 10744763; 10782990; 10811012; 10820433; 10878576; 10952989; 11154262; 11162833; 11211234; 11359773; 11448946; 11495898; 11551945; 11579095; 11847341; 12171600; 12239168; 12384504; 12454855; 12475989; 12477932; 12510156; 12586546; 12761180; 14522966; 14557269; 14651992; 14680475; 14688370; 14724572; 15048855; 15249224; 15273249; 15304097; 15304344; 15326477; 15356147; 15461802; 15489334; 15708845; 15728454; 15923648; 16120828; 16341674; 16643845; 16966330; 17241234; 17254968; 17380123; 17906618; 18192325; 18950637; 19082897; 19622861; 19706373; 19913121; 20053787; 20056178; 20110267; 20162623; 20188673; 20378550; 20626350; 20628086; 20724307; 21757713; 21832049; 21900206; 21911485; 21988832; 22157753; 22515544; 22522454; 23602568; 23625915; 23824909
description: mitogen-activated protein kinase 11
database cross reference: Ensembl:ENSG00000185386
database cross reference: HGNC:6873
database cross reference: HPRD:04208
database cross reference: MIM:602898
database cross reference: Vega:OTTHUMG00000150226

MAPK13
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MAPK 13
alternative term: MAPK-13
alternative term: PRKM13
alternative term: SAPK4
alternative term: p38delta
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAPK13
full name from nomenclature authority: mitogen-activated protein kinase 13
NCBI GeneID: 5603
NCBI LocusTag: RP1-179N16.4
gene map location: 6p21.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: IDA, PMID: 9218798); GO_0004674 (EC: IDA, PMID: 12244047); GO_0004707 (EC: IDA, PMID: 9218798); GO_0005515 (EC: IPI, PMID: 19135240); GO_0005524 (EC: IEA); GO_0005829 (EC: TAS); GO_0006351 (EC: IEA); GO_0006355 (EC: IEA); GO_0006950 (EC: IDA, PMID: 9218798); GO_0006970 (EC: IDA, PMID: 9731215); GO_0007049 (EC: IEA); GO_0007265 (EC: TAS); GO_0018105 (EC: IDA, PMID: 15850461); GO_0032755 (EC: IMP, PMID: 19279008); GO_0035556 (EC: IDA, PMID: 9218798); GO_0048011 (EC: TAS); GO_0050729 (EC: IC, PMID: 19279008)
has PubMed association: PMID: 8125298; 9199504; 9207191; 9218798; 9295308; 9297626; 9374491; 9628874; 9731215; 9841871; 10066767; 10201954; 10727080; 11378392; 11500363; 11520933; 12080077; 12171600; 12239168; 12244047; 12477932; 12482858; 12810719; 14574404; 15231748; 15340077; 15489334; 15850461; 16344560; 16644870; 16751776; 17906618; 18367666; 18559936; 18624398; 19135240; 19279008; 19816939; 19913121; 20056178; 20090411; 20478268; 20628086; 20804750; 20805296; 21832049; 21906983; 21988832; 22199349; 22730327; 23187130; 23383273; 23590314; 23602568; 23722928; 23798682; 23878395
description: mitogen-activated protein kinase 13
database cross reference: Ensembl:ENSG00000156711
database cross reference: HGNC:6875
database cross reference: HPRD:09113
database cross reference: MIM:602899
database cross reference: Vega:OTTHUMG00000014587

MAP2K1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CFC3
alternative term: MAPKK1
alternative term: MEK1
alternative term: MKK1
alternative term: PRKMK1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAP2K1
full name from nomenclature authority: mitogen-activated protein kinase kinase 1
NCBI GeneID: 5604
gene map location: 15q22.1-q22.33
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: TAS); GO_0000186 (EC: TAS); GO_0000187 (EC: TAS, PMID: 19565474); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0003056 (EC: IEA); GO_0004672 (EC: TAS, PMID: 10570282); GO_0004674 (EC: TAS); GO_0004708 (EC: IDA, PMID: 8388392); GO_0004712 (EC: TAS, PMID: 19565474); GO_0004713 (EC: IEA); GO_0004728 (EC: IEA); GO_0005515 (EC: IPI, PMID: 15299019); GO_0005524 (EC: IEA); GO_0005634 (EC: TAS, PMID: 19565474); GO_0005737 (EC: IDA); GO_0005739 (EC: TAS, PMID: 19565474); GO_0005769 (EC: TAS, PMID: 19565474); GO_0005770 (EC: TAS, PMID: 19565474); GO_0005794 (EC: TAS, PMID: 19565474); GO_0005816 (EC: IEA); GO_0005829 (EC: TAS, PMID: 19565474); GO_0005886 (EC: IDA); GO_0005925 (EC: TAS, PMID: 19565474); GO_0005938 (EC: IEA); GO_0006928 (EC: TAS, PMID: 10912793); GO_0006935 (EC: TAS, PMID: 10570282); GO_0006979 (EC: IEA); GO_0007050 (EC: IMP, PMID: 9765203); GO_0007067 (EC: IEA); GO_0007165 (EC: TAS, PMID: 10570282); GO_0007173 (EC: TAS); GO_0007264 (EC: TAS); GO_0007265 (EC: TAS); GO_0007411 (EC: TAS); GO_0008283 (EC: IEA); GO_0008285 (EC: IDA, PMID: 9765203); GO_0008286 (EC: TAS); GO_0008543 (EC: TAS); GO_0010628 (EC: IMP, PMID: 15155804); GO_0017016 (EC: IEA); GO_0030216 (EC: IEA); GO_0030335 (EC: IEA); GO_0031435 (EC: IEA); GO_0032320 (EC: IEA); GO_0032402 (EC: IEA); GO_0032839 (EC: IEA); GO_0032872 (EC: TAS, PMID: 19565474); GO_0032968 (EC: IEA); GO_0034111 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035666 (EC: TAS); GO_0038095 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0043204 (EC: IEA); GO_0043539 (EC: IDA, PMID: 8388392); GO_0045087 (EC: TAS); GO_0045597 (EC: IEA); GO_0046579 (EC: IEA); GO_0047496 (EC: IEA); GO_0048011 (EC: TAS); GO_0048313 (EC: IEA); GO_0048471 (EC: IEA); GO_0048678 (EC: IEA); GO_0048870 (EC: IEA); GO_0051291 (EC: IEA); GO_0051384 (EC: IEA); GO_0051403 (EC: TAS); GO_0060674 (EC: IEA); GO_0060711 (…
has PubMed association: PMID: 1281467; 7601337; 7624324; 7731720; 7957875; 7969158; 8131746; 8157000; 8226933; 8388392; 8394352; 8529659; 8621729; 8626767; 8631303; 8900182; 8939914; 9006895; 9069267; 9223324; 9311917; 9325171; 9351825; 9465908; 9553107; 9558095; 9563949; 9564043; 9621077; 9733512; 9765203; 9841871; 10395327; 10402467; 10409742; 10489373; 10509564; 10523642; 10570282; 10712923; 10716983; 10748187; 10757792; 10780709; 10799874; 10806207; 10828601; 10848576; 10912793; 10958680; 10969079; 10982368; 10997882; 11044099; 11044439; 11104681; 11134045; 11226259; 11260070; 11266467; 11278389; 11279118; 11352917; 11409852; 11520933; 11535599; 11579140; 11604401; 11684694; 11726657; 11741534; 11741894; 11823456; 11891225; 11940661; 11948406; 12032872; 12063167; 12089333; 12167619; 12370306; 12456688; 12477932; 12482669; 12522135; 12522145; 12531514; 12556561; 12594221; 12609978; 12612059; 12663662; 12682854; 12689928; 12697810; 12775419; 12788955; 12792650; 12807433; 12839928; 12917419; 12975377; 14500727; 14581471; 14656894; 14672918; 14724641; 15020233; 15021912; 15069060; 15090600; 15118098; 15155804; 15231747; 15258589; 15276183; 15284233; 15292274; 15297310; 15299019; 15302887; 15353548; 15485920; 15520859; 15538402; 15543157; 15557124; 15572374; 15615716; 15638726; 15657353; 15657590; 15665520; 15757891; 15866172; 15888452; 15979847; 16086581; 16093354; 16239230; 16291755; 16313339; 16344560; 16439621; 16454711; 16533805; 16728640; 16737746; 16810323; 16820947; 16861903; 16888650; 16957420; 17038630; 17054908; 17101779; 17182854; 17192257; 17197157; 17260965; 17366577; 17419998; 17461449; 17490600; 17603482; 17623298; 17667937; 17704260; 17951252; 17979178; 17981815; 18029348; 18042262; 18060073; 18192500; 18329369; 18332145; 18390968; 18413255; 18424438; 18434598; 18533112; 18556463; 18569454; 18593598; 18617556; 18632602; 18660489; 19001375; 19014680; 19056740; 19133693; 19153083; 19156172; 19164283; 19206169; 19261809; 19322201; 19342664; 19411838; 19447520; 19453261; 195000…
description: mitogen-activated protein kinase kinase 1
database cross reference: HGNC:6840
database cross reference: HPRD:01469
database cross reference: MIM:176872

MAP2K3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MAPKK3
alternative term: MEK3
alternative term: MKK3
alternative term: PRKMK3
alternative term: SAPKK-2
alternative term: SAPKK2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAP2K3
full name from nomenclature authority: mitogen-activated protein kinase kinase 3
NCBI GeneID: 5606
gene map location: 17q11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: TAS); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004702 (EC: IBA); GO_0004708 (EC: IBA); GO_0004713 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11980910); GO_0005524 (EC: IEA); GO_0005654 (EC: TAS); GO_0005737 (EC: IBA); GO_0005829 (EC: TAS); GO_0006954 (EC: IEA); GO_0007165 (EC: TAS, PMID: 7839144); GO_0019901 (EC: IPI, PMID: 11279118); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035666 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042035 (EC: IEA); GO_0045087 (EC: TAS); GO_0045860 (EC: IDA, PMID: 11980910); GO_0045893 (EC: IDA, PMID: 11980910); GO_0051403 (EC: TAS); GO_0060048 (EC: IEA)
has PubMed association: PMID: 7750576; 7839144; 8125298; 8226933; 8622669; 8626699; 8900184; 9038352; 9162092; 9465908; 9768359; 9786855; 9841871; 10497253; 10856288; 10997882; 11062067; 11062068; 11181995; 11279118; 11279172; 11414763; 11562357; 11971971; 11980910; 12024021; 12054652; 12377770; 12477932; 12589052; 12761180; 13679851; 14702039; 15276183; 15375157; 15489334; 15516490; 15677464; 15778394; 15797859; 15866172; 16341674; 16344560; 16709574; 16709866; 16728640; 17255949; 17406030; 17438131; 19047046; 19302196; 19672773; 19737936; 20067578; 20173330; 20213747; 20805296; 21044950; 21048031; 21137025; 21139048; 21206905; 21368234; 21832049; 21890473; 21900206; 21906983; 21963094; 21988832; 22154358; 22164285; 22505724; 22623531; 22696064; 23000965; 23455922; 23602568
description: mitogen-activated protein kinase kinase 3
database cross reference: Ensembl:ENSG00000034152
database cross reference: HGNC:6843
database cross reference: HPRD:03816
database cross reference: MIM:602315
database cross reference: Vega:OTTHUMG00000134322

MAP2K6
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MAPKK6
alternative term: MEK6
alternative term: MKK6
alternative term: PRKMK6
alternative term: SAPKK-3
alternative term: SAPKK3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAP2K6
full name from nomenclature authority: mitogen-activated protein kinase kinase 6
NCBI GeneID: 5608
gene map location: 17q24.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: TAS); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0002931 (EC: IEA); GO_0004702 (EC: IBA); GO_0004708 (EC: IBA); GO_0004713 (EC: IEA); GO_0005515 (EC: IPI, PMID: 15229216); GO_0005524 (EC: IEA); GO_0005654 (EC: TAS); GO_0005737 (EC: IBA); GO_0005829 (EC: TAS); GO_0005856 (EC: IEA); GO_0006351 (EC: IEA); GO_0006355 (EC: IEA); GO_0006915 (EC: IEA); GO_0006975 (EC: TAS, PMID: 10848581); GO_0007050 (EC: TAS, PMID: 10848581); GO_0007165 (EC: TAS, PMID: 8621675); GO_0019901 (EC: IPI, PMID: 11279118); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035666 (EC: TAS); GO_0035872 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042493 (EC: IEA); GO_0042692 (EC: TAS); GO_0043065 (EC: IEA); GO_0045087 (EC: TAS); GO_0051149 (EC: TAS); GO_0051403 (EC: TAS); GO_0060048 (EC: IEA); GO_0070423 (EC: TAS); GO_0072709 (EC: IEA)
has PubMed association: PMID: 7750576; 8125298; 8621675; 8622669; 8626699; 8663074; 8861944; 9218798; 9430721; 9768359; 9808624; 9841871; 10094049; 10497253; 10570156; 10702308; 10838074; 10848581; 10961885; 11062067; 11062068; 11104681; 11279118; 11460167; 11562357; 11689443; 11727828; 11836244; 11971971; 12054652; 12242293; 12477932; 12509443; 12556533; 12589052; 12609980; 12697810; 12761180; 12820963; 14633987; 15229216; 15276183; 15375157; 15489334; 15492008; 15516490; 15550393; 15590691; 15677464; 15717329; 15722372; 15764709; 15778394; 15790570; 15866172; 15923648; 16157600; 16313339; 16342939; 16344560; 16498455; 16728640; 16893890; 16960152; 17079228; 17255097; 17255949; 17363905; 17363973; 17384642; 18327563; 19047046; 19141286; 19234473; 19302196; 19672773; 19675569; 19737936; 19846005; 19913121; 20067578; 20162623; 20213747; 20364819; 20628086; 20706999; 20805296; 20869211; 20932476; 21078955; 21139048; 21308746; 21368234; 21890473; 21926646; 22154358; 22164285; 22383536; 22569225; 23606331; 23744074
description: mitogen-activated protein kinase kinase 6
database cross reference: HGNC:6846
database cross reference: HPRD:03155
database cross reference: MIM:601254

MAP2K7
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: Jnkk2
alternative term: MAPKK7
alternative term: MKK7
alternative term: PRKMK7
alternative term: SAPKK-4
alternative term: SAPKK4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAP2K7
full name from nomenclature authority: mitogen-activated protein kinase kinase 7
NCBI GeneID: 5609
gene map location: 19p13.3-p13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000287 (EC: IDA, PMID: 9535930); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004674 (EC: IEA); GO_0004708 (EC: IDA, PMID: 9535930); GO_0004713 (EC: IEA); GO_0005515 (EC: IPI, PMID: 15299019); GO_0005524 (EC: IEA); GO_0005634 (EC: ISS); GO_0005737 (EC: ISS); GO_0005829 (EC: TAS); GO_0006915 (EC: IEA); GO_0006950 (EC: IDA, PMID: 9535930); GO_0007165 (EC: TAS, PMID: 9535930); GO_0007254 (EC: TAS); GO_0007257 (EC: ISS); GO_0008022 (EC: IEA); GO_0008545 (EC: IEA); GO_0019901 (EC: IPI, PMID: 14697235); GO_0019903 (EC: ISS); GO_0031435 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035666 (EC: TAS); GO_0038095 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0043525 (EC: IEA); GO_0045087 (EC: TAS); GO_0051403 (EC: IDA, PMID: 9535930); GO_0051403 (EC: TAS); GO_0072709 (EC: IEA)
has PubMed association: PMID: 9207092; 9312068; 9372971; 9488659; 9535930; 9661668; 10187804; 10347227; 10490659; 10629060; 10713157; 10756100; 10969079; 11062067; 11104681; 11274363; 11318610; 11390361; 11726277; 11836244; 11891214; 11959861; 11959862; 12138158; 12189133; 12220515; 12477932; 12659851; 12821118; 13130464; 14500727; 14697235; 14743220; 14968112; 15001580; 15276183; 15299019; 15465036; 15489334; 15753034; 15866172; 16169070; 16243842; 16313339; 16442502; 16456539; 16533805; 16802349; 16840345; 17110930; 17189706; 17485467; 18222647; 18286207; 18343408; 18436711; 18713996; 19302196; 19322201; 19737936; 19910486; 20067578; 20156194; 21074392; 21139048; 21148294; 21749326; 21890473; 21906983; 21988832; 22154358; 22159816; 22267733; 22268729; 22505724; 22509080; 22623531; 22899651; 22903704; 22939624; 23341463; 24104474; 24250222
description: mitogen-activated protein kinase kinase 7
database cross reference: Ensembl:ENSG00000076984
database cross reference: HGNC:6847
database cross reference: MIM:603014
database cross reference: Vega:OTTHUMG00000137368

PRNP
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ASCR
alternative term: AltPrP
alternative term: CD230
alternative term: CJD
alternative term: GSS
alternative term: KURU
alternative term: PRIP
alternative term: PrP
alternative term: PrP27-30
alternative term: PrP33-35C
alternative term: PrPc
alternative term: p27-30
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PRNP
full name from nomenclature authority: prion protein
NCBI GeneID: 5621
NCBI LocusTag: RP5-1068H6.2
gene map location: 20p13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001933 (EC: ISS); GO_0005507 (EC: IDA, PMID: 11900542); GO_0005507 (EC: TAS, PMID: 16294306); GO_0005515 (EC: IPI, PMID: 16286452); GO_0005634 (EC: IEA); GO_0005737 (EC: TAS, PMID: 16004966); GO_0005741 (EC: IDA); GO_0005783 (EC: ISS); GO_0005794 (EC: ISS); GO_0005886 (EC: ISS); GO_0006878 (EC: NAS, PMID: 16004966); GO_0006979 (EC: ISS); GO_0007050 (EC: IEA); GO_0007411 (EC: TAS); GO_0007611 (EC: IEA); GO_0008017 (EC: IDA, PMID: 16004966); GO_0008152 (EC: TAS, PMID: 3755672); GO_0015631 (EC: IDA, PMID: 16004966); GO_0016021 (EC: IEA); GO_0019898 (EC: TAS, PMID: 16004966); GO_0031225 (EC: IEA); GO_0032689 (EC: ISS); GO_0032700 (EC: ISS); GO_0032703 (EC: ISS); GO_0042802 (EC: IPI, PMID: 16286452); GO_0043008 (EC: IEA); GO_0043066 (EC: IEA); GO_0043433 (EC: ISS); GO_0045121 (EC: ISS); GO_0046007 (EC: ISS); GO_0046686 (EC: IEA); GO_0046688 (EC: IEA); GO_0050860 (EC: ISS); GO_0051087 (EC: IEA); GO_0051260 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070885 (EC: ISS)
has PubMed association: PMID: 1346338; 1347910; 1351748; 1352724; 1357663; 1363802; 1363810; 1439789; 1671440; 1672107; 1677164; 1678248; 1683708; 1736177; 2159587; 2180366; 2564168; 2567794; 2572450; 2783132; 3014653; 3755672; 7485229; 7572084; 7592679; 7630420; 7642585; 7699395; 7783876; 7902693; 7902972; 7906019; 7913755; 8105771; 8364585; 8461023; 8676499; 8797471; 8797472; 8909447; 8962161; 9266722; 9384372; 9473220; 9482303; 9786248; 9799790; 10090891; 10581485; 10618385; 10631141; 10790216; 10900000; 10954699; 10970892; 10987652; 10988071; 11032800; 11060296; 11062072; 11100730; 11120925; 11161453; 11220690; 11244488; 11278562; 11283320; 11438139; 11559357; 11571277; 11584448; 11593450; 11684342; 11704923; 11709001; 11756421; 11775001; 11780052; 11787070; 11833672; 11840201; 11882649; 11900542; 11961239; 11986958; 12034503; 12070046; 12084159; 12093732; 12161431; 12186633; 12205650; 12356762; 12356908; 12359724; 12392052; 12399017; 12459456; 12464104; 12477932; 12514748; 12543108; 12547204; 12568340; 12590162; 12601712; 12621436; 12645301; 12659837; 12679034; 12679875; 12682740; 12684540; 12690204; 12692258; 12694397; 12719777; 12778138; 12796830; 12805563; 12867116; 12917418; 12917444; 12946346; 12952977; 12970341; 14519851; 14576159; 14593432; 14610121; 14616310; 14623188; 14645231; 14668351; 14702039; 14744790; 14745079; 14761942; 14970845; 14983221; 15050367; 15123682; 15131108; 15140132; 15145944; 15146195; 15148589; 15203115; 15208260; 15215178; 15247220; 15258222; 15266305; 15277640; 15304595; 15342556; 15469448; 15488240; 15489334; 15539564; 15555583; 15557533; 15583862; 15591591; 15609351; 15639746; 15684434; 15748158; 15775715; 15837581; 15846375; 15850959; 15862295; 15946217; 15987701; 15997418; 16004966; 16009550; 16025285; 16051190; 16099550; 16099923; 16119432; 16120605; 16156720; 16159877; 16169070; 16175355; 16187142; 16192387; 16215457; 16215462; 16217673; 16263114; 16286452; 16287045; 16294306; 16298483; 16314483; 16315279; 16324095; 16342955; 16344560; 16432880; 1…
description: prion protein
database cross reference: Ensembl:ENSG00000171867
database cross reference: HGNC:9449
database cross reference: HPRD:01453
database cross reference: MIM:176640
database cross reference: Vega:OTTHUMG00000031786

RELN
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LIS2
alternative term: PRO1598
alternative term: RL
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RELN
full name from nomenclature authority: reelin
NCBI GeneID: 5649
gene map location: 7q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000904 (EC: ISS); GO_0001764 (EC: ISS); GO_0004712 (EC: ISS); GO_0005578 (EC: IEA); GO_0005615 (EC: ISS); GO_0005737 (EC: ISS); GO_0007155 (EC: IEA); GO_0007411 (EC: ISS); GO_0007417 (EC: ISS); GO_0007420 (EC: ISS); GO_0007616 (EC: IEA); GO_0008236 (EC: IEA); GO_0008306 (EC: IEA); GO_0010001 (EC: ISS); GO_0010976 (EC: ISS); GO_0014068 (EC: IEA); GO_0016358 (EC: IEA); GO_0018108 (EC: ISS); GO_0021511 (EC: ISS); GO_0021517 (EC: IEA); GO_0021766 (EC: ISS); GO_0021800 (EC: ISS); GO_0030425 (EC: ISS); GO_0032008 (EC: IEA); GO_0032793 (EC: ISS); GO_0038026 (EC: ISS, PMID: 10571240); GO_0045860 (EC: ISS); GO_0046872 (EC: IEA); GO_0048265 (EC: ISS); GO_0050731 (EC: ISS, PMID: 10571240); GO_0050795 (EC: ISS); GO_0050804 (EC: ISS); GO_0051057 (EC: ISS); GO_0051968 (EC: ISS); GO_0061003 (EC: ISS); GO_0061098 (EC: ISS); GO_0070325 (EC: ISS, PMID: 10571240); GO_0070326 (EC: ISS, PMID: 10571240); GO_0090129 (EC: ISS); GO_0097114 (EC: IEA); GO_0097119 (EC: IEA); GO_0097120 (EC: IEA); GO_0097477 (EC: IEA); GO_1900273 (EC: ISS); GO_1902078 (EC: IEA); GO_2000310 (EC: ISS); GO_2000463 (EC: ISS); GO_2000969 (EC: ISS)
has PubMed association: PMID: 7715726; 9049633; 9847074; 9861036; 10328932; 10571240; 10571241; 10612399; 10973257; 11137154; 11317216; 11408330; 11520926; 11689558; 11711858; 11880184; 12082559; 12087179; 12122039; 12135781; 12143388; 12167620; 12192627; 12363196; 12363388; 12376533; 12399956; 12645087; 12670700; 12690205; 12834112; 12853948; 12899622; 12931209; 14515139; 14702039; 14702098; 15006702; 15048647; 15048648; 15464360; 15558079; 15655250; 15690491; 15718228; 15790807; 15820235; 15961543; 15965968; 16266828; 16472607; 16481437; 16510495; 16556465; 16941662; 16951405; 16979599; 17310238; 17360894; 17365098; 17366345; 17431900; 17548821; 17621165; 17684500; 17696989; 17870056; 17955477; 18282107; 18384059; 18449964; 18593473; 18597938; 18599960; 19010793; 19054571; 19058789; 19086053; 19156168; 19230858; 19401682; 19436241; 19633980; 19691043; 19713529; 19720620; 19847460; 19922905; 19936619; 19948739; 19956836; 20010491; 20025970; 20053715; 20064940; 20150511; 20379614; 20431428; 20434133; 20436377; 20442744; 20452100; 20468075; 20554015; 20554749; 20642811; 20659411; 20697953; 20727978; 20734148; 20847288; 20882487; 21145461; 21315259; 21395570; 21549172; 21603580; 21630058; 21745129; 21814183; 21844191; 21863557; 22006801; 22006802; 22023759; 22203331; 22393371; 22394407; 22419519; 22495348; 22614235; 22797278; 22933789; 23082219; 23216241; 23236151; 23274163; 23277132; 23632168; 23934736; 24170657; 24239537
description: reelin
database cross reference: Ensembl:ENSG00000189056
database cross reference: HGNC:9957
database cross reference: HPRD:02742
database cross reference: MIM:600514
database cross reference: Vega:OTTHUMG00000157247

PSEN1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AD3
alternative term: FAD
alternative term: PS-1
alternative term: PS1
alternative term: S182
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PSEN1
full name from nomenclature authority: presenilin 1
NCBI GeneID: 5663
gene map location: 14q24.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 14
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000045 (EC: IEA); GO_0000122 (EC: IEA); GO_0000139 (EC: IEA); GO_0000186 (EC: IEA); GO_0000776 (EC: IDA, PMID: 9298903); GO_0001568 (EC: IEA); GO_0001708 (EC: IEA); GO_0001756 (EC: IEA); GO_0001764 (EC: IEA); GO_0001921 (EC: IEA); GO_0001947 (EC: IEA); GO_0002244 (EC: IEA); GO_0002286 (EC: IEA); GO_0002573 (EC: IEA); GO_0004175 (EC: IDA, PMID: 8755489); GO_0004190 (EC: IEA); GO_0005262 (EC: IMP, PMID: 16959576); GO_0005515 (EC: IPI, PMID: 11076969); GO_0005640 (EC: IDA, PMID: 9246482); GO_0005739 (EC: IDA, PMID: 12377771); GO_0005743 (EC: IBA); GO_0005765 (EC: IBA); GO_0005783 (EC: IDA, PMID: 15274632); GO_0005789 (EC: IEA); GO_0005790 (EC: IDA, PMID: 9632714); GO_0005791 (EC: IDA, PMID: 9632714); GO_0005794 (EC: IDA, PMID: 15274632); GO_0005813 (EC: IDA, PMID: 9298903); GO_0005887 (EC: IDA, PMID: 15274632); GO_0005938 (EC: IBA); GO_0006486 (EC: IEA); GO_0006509 (EC: IDA, PMID: 15274632); GO_0006816 (EC: IBA); GO_0006839 (EC: IEA); GO_0006974 (EC: IEA); GO_0006979 (EC: IEA); GO_0007175 (EC: IEA); GO_0007219 (EC: IEA); GO_0007220 (EC: IBA); GO_0007220 (EC: TAS, PMID: 15274632); GO_0007613 (EC: IEA); GO_0008013 (EC: IPI, PMID: 11104755); GO_0009791 (EC: IEA); GO_0009986 (EC: IBA); GO_0015031 (EC: IEA); GO_0015813 (EC: IEA); GO_0015871 (EC: IEA); GO_0016020 (EC: IDA); GO_0016021 (EC: TAS, PMID: 7596406); GO_0016080 (EC: IEA); GO_0016324 (EC: IBA); GO_0016337 (EC: IMP, PMID: 11953314); GO_0016485 (EC: IDA, PMID: 15274632); GO_0021795 (EC: IEA); GO_0021870 (EC: IEA); GO_0021904 (EC: IEA); GO_0022617 (EC: TAS); GO_0030018 (EC: IBA); GO_0030165 (EC: IPI, PMID: 10551805); GO_0030198 (EC: TAS); GO_0030326 (EC: IEA); GO_0030424 (EC: IBA); GO_0030426 (EC: IBA); GO_0031410 (EC: IEA); GO_0031594 (EC: IBA); GO_0031965 (EC: IDA, PMID: 9298903); GO_0032436 (EC: IEA); GO_0032469 (EC: IDA, PMID: 17431506); GO_0032469 (EC: IGI, PMID: 16959576); GO_0034205 (EC: IEA); GO_0035253 (EC: IBA); GO_0035556 (EC: IEA); GO_0042325 (EC: IDA, PMID: 9689133); GO_0042640 (EC: IEA); GO_0042987 (E…
has PubMed association: PMID: 1303289; 1349467; 1411576; 7550356; 7596406; 7623584; 7651536; 8125298; 8574969; 8634711; 8634712; 8641442; 8733303; 8742474; 8755489; 8804415; 8837617; 8875251; 8878479; 8922407; 8931704; 9007311; 9013610; 9052708; 9070286; 9073509; 9144240; 9172170; 9173929; 9223106; 9223340; 9225696; 9246482; 9298817; 9298903; 9384602; 9436726; 9437013; 9443865; 9485372; 9507958; 9521418; 9521423; 9544835; 9632714; 9689133; 9712537; 9719376; 9738936; 9771752; 9831473; 9833068; 9851443; 9851450; 9852041; 9915968; 10025789; 10037471; 10069390; 10077672; 10090481; 10092585; 10200054; 10206644; 10206645; 10208579; 10208590; 10341227; 10366599; 10369872; 10401002; 10439444; 10441572; 10446169; 10447269; 10521466; 10527805; 10533070; 10545183; 10551805; 10587643; 10593990; 10631141; 10635315; 10801777; 10801983; 10805794; 10811883; 10854253; 10891589; 10899933; 10993067; 11027672; 11030797; 11076969; 11094121; 11104755; 11110974; 11129109; 11140838; 11168528; 11200686; 11226248; 11389157; 11436125; 11444983; 11504726; 11518718; 11524469; 11568920; 11710891; 11719200; 11738826; 11744687; 11755019; 11757955; 11775232; 11799129; 11827452; 11836371; 11847232; 11876645; 11891288; 11904448; 11905990; 11912199; 11920851; 11927360; 11943765; 11953314; 11973477; 11987239; 12048239; 12048259; 12050157; 12056836; 12058025; 12070348; 12111439; 12112163; 12119298; 12121968; 12147673; 12192622; 12196555; 12198112; 12207970; 12214059; 12218704; 12230303; 12297048; 12297508; 12354302; 12374741; 12377771; 12413003; 12435726; 12444985; 12460547; 12470641; 12471034; 12477932; 12484344; 12493737; 12495082; 12508121; 12522139; 12535650; 12551931; 12603837; 12609057; 12629514; 12639958; 12660785; 12668610; 12679784; 12686406; 12740439; 12742741; 12752408; 12787561; 12794186; 12805290; 12817569; 12821663; 12843241; 12846562; 12850546; 12885573; 12885769; 12901838; 12925374; 12935881; 12960155; 13678586; 14502086; 14504279; 14515347; 14550564; 14572442; 14576165; 14581682; 14590205; 14625299; 14645205; …
description: presenilin 1
database cross reference: Ensembl:ENSG00000080815
database cross reference: HGNC:9508
database cross reference: HPRD:00087
database cross reference: MIM:104311
database cross reference: Vega:OTTHUMG00000141279

PSEN2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AD3L
alternative term: AD4
alternative term: CMD1V
alternative term: PS2
alternative term: STM2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PSEN2
full name from nomenclature authority: presenilin 2
NCBI GeneID: 5664
gene map location: 1q42.13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: IEA); GO_0000776 (EC: IDA, PMID: 9298903); GO_0001666 (EC: IEA); GO_0001708 (EC: IEA); GO_0001756 (EC: IEA); GO_0001933 (EC: IEA); GO_0002244 (EC: IEA); GO_0002286 (EC: IEA); GO_0002573 (EC: IEA); GO_0004175 (EC: IBA); GO_0004190 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10366599); GO_0005637 (EC: IDA, PMID: 9298903); GO_0005743 (EC: IBA); GO_0005765 (EC: IBA); GO_0005783 (EC: IDA, PMID: 15274632); GO_0005789 (EC: IEA); GO_0005794 (EC: IDA, PMID: 15274632); GO_0005813 (EC: IDA, PMID: 9298903); GO_0005829 (EC: IEA); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 15274632); GO_0005938 (EC: IBA); GO_0006509 (EC: IDA, PMID: 15274632); GO_0006816 (EC: IBA); GO_0007176 (EC: IEA); GO_0007219 (EC: TAS); GO_0007220 (EC: IBA); GO_0007220 (EC: TAS, PMID: 15274632); GO_0007613 (EC: IEA); GO_0009986 (EC: IBA); GO_0015031 (EC: IEA); GO_0016324 (EC: IBA); GO_0016485 (EC: IDA, PMID: 15274632); GO_0021904 (EC: IEA); GO_0030018 (EC: IBA); GO_0030326 (EC: IEA); GO_0030424 (EC: IBA); GO_0030426 (EC: IBA); GO_0030900 (EC: IEA); GO_0031293 (EC: TAS); GO_0031333 (EC: IEA); GO_0031594 (EC: IBA); GO_0032091 (EC: IEA); GO_0032469 (EC: IEA); GO_0035253 (EC: IBA); GO_0035556 (EC: IEA); GO_0040011 (EC: IEA); GO_0042640 (EC: IEA); GO_0042987 (EC: IBA); GO_0042987 (EC: TAS, PMID: 15274632); GO_0043025 (EC: IBA); GO_0043065 (EC: TAS); GO_0043085 (EC: IDA, PMID: 15274632); GO_0043198 (EC: IBA); GO_0043234 (EC: IDA, PMID: 9632714); GO_0045121 (EC: IBA); GO_0048011 (EC: TAS); GO_0048167 (EC: IEA); GO_0048286 (EC: IEA); GO_0048471 (EC: IBA); GO_0048538 (EC: IEA); GO_0048854 (EC: IEA); GO_0050435 (EC: IBA); GO_0050820 (EC: IEA); GO_0050852 (EC: IEA); GO_0060048 (EC: IEA); GO_0097190 (EC: TAS); GO_1902042 (EC: IEA); GO_1902043 (EC: IEA)
has PubMed association: PMID: 7638621; 7638622; 7651536; 8574969; 8618867; 8661049; 8878479; 8939861; 8940094; 8972483; 9050898; 9073509; 9219695; 9223340; 9252383; 9298903; 9384602; 9437013; 9450781; 9521418; 9558331; 9632714; 9683324; 9771752; 9813158; 9852298; 9990034; 10037471; 10069390; 10078972; 10361981; 10366599; 10369872; 10446169; 10497236; 10631141; 10652302; 10677567; 10732806; 10748169; 10854253; 10922078; 10993067; 11001931; 11076969; 11278424; 11436125; 11518718; 11568920; 11719200; 11738826; 11799129; 11847232; 11876645; 11891288; 11904448; 11987239; 12048259; 12058025; 12173418; 12196555; 12198112; 12210343; 12232783; 12297508; 12403846; 12471034; 12477932; 12556443; 12605888; 12639958; 12770698; 12787561; 12817569; 12843241; 12846562; 12885769; 12925374; 14504279; 14577603; 14741365; 14769392; 15004330; 15006697; 15274632; 15474363; 15489334; 15534001; 15537629; 15591316; 15629423; 15663477; 15721744; 15755689; 15776278; 15951428; 15975068; 16014629; 16135086; 16233903; 16258850; 16344560; 16375654; 16423463; 16474849; 16620965; 16630834; 16813565; 17268504; 17268505; 17345043; 17401156; 17401676; 17412506; 17560791; 17614368; 17727891; 17903177; 17986144; 18087668; 18283638; 18293935; 18350357; 18427071; 18591429; 18667258; 18727676; 18842294; 18854154; 18996842; 19036728; 19073399; 19276543; 19382908; 19573580; 19768372; 19834068; 19889971; 19913121; 20008660; 20009122; 20164579; 20301340; 20301414; 20301486; 20333730; 20375137; 20457965; 20468060; 20594621; 20628086; 20677014; 20701429; 20850903; 21163940; 21234330; 21285369; 21409510; 21545304; 21906983; 21914807; 21959359; 21963094; 22027014; 22045484; 22074918; 22249458; 22302987; 22312439; 22503161; 22580083; 22753229; 22755192; 22872014; 23546527; 23589300; 23707529; 23884042; 24145027
description: presenilin 2
database cross reference: Ensembl:ENSG00000143801
database cross reference: HGNC:9509
database cross reference: HPRD:02860
database cross reference: MIM:600759
database cross reference: Vega:OTTHUMG00000037563

PSMD9
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: Rpn4
alternative term: p27
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PSMD9
full name from nomenclature authority: proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
NCBI GeneID: 5715
gene map location: 12q24.31-q24.32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000082 (EC: TAS); GO_0000209 (EC: TAS); GO_0000278 (EC: TAS); GO_0002474 (EC: TAS); GO_0002479 (EC: TAS); GO_0003713 (EC: ISS, PMID: 10567574); GO_0005515 (EC: IPI, PMID: 16189514); GO_0005634 (EC: ISS, PMID: 10567574); GO_0005654 (EC: TAS); GO_0005829 (EC: TAS); GO_0005838 (EC: NAS, PMID: 9653651); GO_0006511 (EC: NAS, PMID: 9653651); GO_0006521 (EC: TAS); GO_0006915 (EC: TAS); GO_0006977 (EC: TAS); GO_0008540 (EC: IDA, Qualifier: colocalizes_with, PMID: 19490896); GO_0010467 (EC: TAS); GO_0016032 (EC: TAS); GO_0016070 (EC: TAS); GO_0016071 (EC: TAS); GO_0031145 (EC: TAS); GO_0032024 (EC: ISS, PMID: 10567574); GO_0034641 (EC: TAS); GO_0042590 (EC: TAS); GO_0042981 (EC: TAS); GO_0043066 (EC: TAS); GO_0043425 (EC: ISS, PMID: 10567574); GO_0044281 (EC: TAS); GO_0045893 (EC: ISS, PMID: 10567574); GO_0046676 (EC: ISS, PMID: 16099819); GO_0051436 (EC: TAS); GO_0051437 (EC: TAS); GO_0051439 (EC: TAS); GO_0070682 (EC: IMP, PMID: 19490896)
has PubMed association: PMID: 8811196; 8889548; 9079628; 9653651; 9811770; 9846577; 10567574; 10799514; 10893419; 11285280; 11940657; 12167863; 12419264; 12477932; 12684681; 12719574; 12750511; 12778072; 12791267; 12808465; 12808466; 12809610; 12830140; 12840737; 12859895; 12914693; 12920286; 12970355; 14527406; 14528300; 14528301; 14550573; 14557625; 14564014; 14614829; 14702039; 15029244; 15146197; 15489334; 16099819; 16189514; 16226712; 16293776; 16341674; 16712791; 17360176; 17409098; 17516568; 18504423; 18694622; 18701138; 18838534; 19041685; 19118035; 19322201; 19490896; 19657726; 19877155; 20069546; 20878082; 21139048; 21439668; 21448710; 21477582; 21496327; 21554682; 21728808; 21813292; 21837501; 21862167; 21871126; 21890473; 21906983; 21988832; 22015693; 22053931; 22134138; 22440256; 22505724; 22863883; 22934761; 22939629; 23000965; 23282078; 23503661; 23618860; 23689538; 23824909; 24026423; 24255178
description: proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
database cross reference: Ensembl:ENSG00000110801
database cross reference: HGNC:9567
database cross reference: HPRD:04394
database cross reference: MIM:603146
database cross reference: Vega:OTTHUMG00000168945

PTEN
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: 10q23del
alternative term: BZS
alternative term: CWS1
alternative term: DEC
alternative term: GLM2
alternative term: MHAM
alternative term: MMAC1
alternative term: PTEN1
alternative term: TEP1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PTEN
full name from nomenclature authority: phosphatase and tensin homolog
NCBI GeneID: 5728
gene map location: 10q23.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000079 (EC: TAS, PMID: 10918569); GO_0000287 (EC: IEA); GO_0001525 (EC: IEA); GO_0001933 (EC: IDA); GO_0002902 (EC: IEA); GO_0004438 (EC: IDA, PMID: 9811831); GO_0004721 (EC: IDA); GO_0004722 (EC: IDA, PMID: 9256433); GO_0004725 (EC: IDA, PMID: 9256433); GO_0005161 (EC: IEA); GO_0005515 (EC: IPI, PMID: 15951562); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005737 (EC: TAS, PMID: 9367992); GO_0005739 (EC: IEA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 10760291); GO_0006470 (EC: IDA, PMID: 9256433); GO_0006470 (EC: TAS, PMID: 9367992); GO_0006644 (EC: TAS); GO_0006661 (EC: TAS); GO_0006915 (EC: ISS); GO_0007092 (EC: IDA); GO_0007173 (EC: TAS); GO_0007270 (EC: ISS); GO_0007416 (EC: ISS); GO_0007417 (EC: ISS); GO_0007507 (EC: ISS); GO_0007568 (EC: IEA); GO_0007584 (EC: IEA); GO_0007611 (EC: ISS); GO_0007613 (EC: IEA); GO_0007626 (EC: ISS); GO_0008138 (EC: IEA); GO_0008283 (EC: TAS, PMID: 10918569); GO_0008284 (EC: ISS); GO_0008285 (EC: IDA, PMID: 19057511); GO_0008285 (EC: IMP, PMID: 10468583); GO_0008289 (EC: IEA); GO_0008543 (EC: TAS); GO_0009749 (EC: IEA); GO_0009898 (EC: IDA, PMID: 10940933); GO_0010043 (EC: IEA); GO_0010975 (EC: ISS); GO_0010997 (EC: IPI); GO_0014067 (EC: TAS, PMID: 18082964); GO_0016314 (EC: IDA, PMID: 9593664); GO_0016314 (EC: TAS); GO_0016477 (EC: ISS); GO_0016605 (EC: IEA); GO_0019899 (EC: IPI, PMID: 16845383); GO_0019901 (EC: IEA); GO_0021542 (EC: ISS); GO_0021955 (EC: ISS); GO_0030165 (EC: IPI, PMID: 10646847); GO_0030336 (EC: IMP, PMID: 17880912); GO_0031642 (EC: IEA); GO_0031647 (EC: IMP, PMID: 10866658); GO_0031658 (EC: IDA); GO_0032286 (EC: ISS); GO_0032355 (EC: IEA); GO_0032535 (EC: ISS); GO_0033032 (EC: IEA); GO_0033198 (EC: IEA); GO_0033555 (EC: ISS); GO_0035176 (EC: ISS); GO_0035335 (EC: IDA, PMID: 9256433); GO_0035749 (EC: ISS); GO_0038095 (EC: TAS); GO_0042493 (EC: IEA); GO_0042711 (EC: IEA); GO_0042995 (EC: IDA, PMID: 10760291); GO_0043005 (EC: ISS); GO_0043065 (EC: IEA); GO_004…
has PubMed association: PMID: 7728760; 8889548; 9072974; 9090379; 9140396; 9187108; 9241266; 9256433; 9259288; 9286463; 9331071; 9345101; 9354427; 9354433; 9356475; 9367992; 9393744; 9399897; 9425889; 9467011; 9593664; 9600246; 9616126; 9635567; 9697695; 9735393; 9794233; 9797362; 9811831; 9832031; 9915974; 9927060; 10051160; 10092130; 10193515; 10213484; 10234502; 10340391; 10400703; 10400993; 10468583; 10555148; 10582703; 10646847; 10706759; 10748157; 10748870; 10760291; 10807691; 10817502; 10852473; 10866302; 10866658; 10889927; 10918569; 10940933; 10955808; 10978354; 11035285; 11058880; 11121587; 11146448; 11156385; 11179477; 11190805; 11230179; 11259087; 11270682; 11303600; 11476065; 11494117; 11504770; 11689295; 11707428; 11729185; 11748304; 11751500; 11784722; 11799112; 11801303; 11836379; 11849740; 11854177; 11857088; 11866895; 11870516; 11875759; 11896207; 11906179; 11908870; 11916965; 11925138; 11932928; 11943731; 11948419; 11948491; 11953696; 11986403; 12055674; 12067477; 12077252; 12077256; 12084351; 12085208; 12091320; 12115563; 12119278; 12133897; 12168088; 12168116; 12176037; 12177006; 12190124; 12203362; 12203792; 12209607; 12235113; 12297295; 12351634; 12367630; 12370746; 12370766; 12379854; 12414663; 12415190; 12429629; 12452054; 12459646; 12471211; 12477932; 12495846; 12508347; 12509854; 12517803; 12535639; 12543774; 12569555; 12569572; 12569575; 12620407; 12620973; 12632503; 12668978; 12684422; 12687015; 12695913; 12712134; 12717346; 12743124; 12743604; 12767263; 12788938; 12804776; 12808147; 12833416; 12839924; 12844284; 12857747; 12869565; 12917336; 12918097; 12960424; 14516315; 14519639; 14532122; 14534684; 14557489; 14559824; 14561749; 14566704; 14574156; 14623110; 14623898; 14642363; 14663583; 14674989; 14699494; 14702039; 14711368; 14724591; 14737113; 14976311; 14981940; 15009714; 15043466; 15046604; 15046605; 15069540; 15126336; 15129904; 15172121; 15196854; 15205473; 15209376; 15231710; 15240129; 15273733; 15287024; 15355975; 15382065; 15453811; 15457582; 154680…
description: phosphatase and tensin homolog
database cross reference: HGNC:9588
database cross reference: HPRD:03431
database cross reference: MIM:601728

PTGS2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: COX-2
alternative term: COX2
alternative term: GRIPGHS
alternative term: PGG/HS
alternative term: PGHS-2
alternative term: PHS-2
alternative term: hCox-2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PTGS2
full name from nomenclature authority: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
NCBI GeneID: 5743
gene map location: 1q25.2-q25.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001516 (EC: ISS); GO_0001516 (EC: NAS); GO_0001525 (EC: IEA); GO_0004601 (EC: NAS, PMID: 14511332); GO_0004666 (EC: IDA, PMID: 1380156); GO_0005634 (EC: ISS); GO_0005737 (EC: IDA, PMID: 14511332); GO_0005737 (EC: ISS); GO_0005789 (EC: TAS); GO_0006693 (EC: TAS, PMID: 9630216); GO_0006928 (EC: TAS, PMID: 9630216); GO_0006954 (EC: IEA); GO_0006979 (EC: IEA); GO_0007566 (EC: IEA); GO_0007612 (EC: IEA); GO_0007613 (EC: IEA); GO_0008217 (EC: ISS); GO_0008285 (EC: IEA); GO_0008289 (EC: IEA); GO_0009750 (EC: IEA); GO_0010042 (EC: IEA); GO_0010226 (EC: IEA); GO_0010575 (EC: ISS, PMID: 9630216); GO_0019233 (EC: IEA); GO_0019369 (EC: TAS); GO_0019371 (EC: IDA, PMID: 1380156); GO_0019371 (EC: TAS); GO_0019372 (EC: TAS); GO_0019899 (EC: IPI, PMID: 16373578); GO_0020037 (EC: ISS); GO_0030282 (EC: IEA); GO_0030728 (EC: IEA); GO_0031394 (EC: NAS); GO_0031622 (EC: ISS); GO_0031915 (EC: IEA); GO_0032227 (EC: IEA); GO_0032355 (EC: IEA); GO_0032496 (EC: IEA); GO_0033280 (EC: IEA); GO_0034612 (EC: IEA); GO_0034644 (EC: IEA); GO_0035633 (EC: IEA); GO_0042346 (EC: IEA); GO_0042493 (EC: IEA); GO_0042640 (EC: IEA); GO_0042803 (EC: IEA); GO_0043005 (EC: IDA, PMID: 12355421); GO_0043065 (EC: IEA); GO_0043234 (EC: IEA); GO_0044281 (EC: TAS); GO_0045429 (EC: ISS, PMID: 9630216); GO_0045786 (EC: IEA); GO_0045907 (EC: IEA); GO_0045986 (EC: IEA); GO_0045987 (EC: IEA); GO_0046697 (EC: IEA); GO_0046872 (EC: IEA); GO_0048661 (EC: IEA); GO_0050473 (EC: TAS); GO_0050727 (EC: NAS, PMID: 14511332); GO_0050873 (EC: IEA); GO_0051384 (EC: IEA); GO_0051926 (EC: IEA); GO_0051968 (EC: IEA); GO_0070542 (EC: IEA); GO_0071260 (EC: IEA); GO_0071318 (EC: IEA); GO_0071456 (EC: IEP); GO_0071636 (EC: ISS, PMID: 9630216); GO_0090050 (EC: ISS, PMID: 9630216); GO_0090271 (EC: ISS, PMID: 9630216); GO_0090336 (EC: ISS); GO_0090362 (EC: ISS)
has PubMed association: PMID: 1380156; 1536575; 4514999; 7510883; 7521167; 7945196; 7947975; 8074655; 8181472; 8473346; 8581564; 8643612; 8889548; 9140046; 9520467; 9545330; 9630216; 9639560; 9661070; 10075740; 10487712; 10705655; 10811226; 10813584; 10842192; 10999846; 10999850; 11309440; 11401839; 11432874; 11687965; 11705852; 11712072; 11809691; 11809750; 11844819; 11847219; 11850206; 11867761; 11880271; 11891188; 11891209; 11894121; 11897504; 11901151; 11906292; 11911965; 11913955; 11920472; 11920515; 11939728; 11948128; 11957147; 11959891; 11972392; 11981837; 11992399; 11994539; 12006564; 12016158; 12021045; 12032335; 12050157; 12050227; 12051953; 12067908; 12070598; 12072439; 12086404; 12124799; 12131767; 12143054; 12145315; 12162677; 12164325; 12167656; 12174888; 12193665; 12195707; 12197220; 12205039; 12209724; 12209745; 12213900; 12218179; 12324457; 12349897; 12354292; 12355421; 12377741; 12378621; 12391274; 12391278; 12393863; 12393872; 12397176; 12401798; 12405290; 12433707; 12444028; 12450219; 12452062; 12459168; 12462194; 12470703; 12477932; 12480928; 12485854; 12485915; 12488433; 12493747; 12498388; 12505789; 12519124; 12519748; 12532440; 12532441; 12533667; 12555215; 12578839; 12579269; 12591723; 12592372; 12598658; 12600292; 12626523; 12628757; 12636104; 12642362; 12654832; 12664576; 12664596; 12664644; 12665651; 12667327; 12677571; 12679908; 12684668; 12692419; 12698187; 12701770; 12718655; 12720297; 12727794; 12743126; 12748469; 12750248; 12751754; 12754192; 12759151; 12761889; 12763047; 12767510; 12767532; 12770691; 12771929; 12777984; 12782823; 12784332; 12789263; 12800228; 12800231; 12800245; 12813143; 12821125; 12821538; 12832284; 12835322; 12837757; 12838502; 12839690; 12839952; 12842195; 12855643; 12860389; 12865795; 12871860; 12875991; 12881220; 12882963; 12883661; 12883688; 12885872; 12891667; 12907138; 12914528; 12920574; 12939602; 12954496; 12956275; 12957358; 12970159; 12970891; 13680221; 14501677; 14505259; 14507922; 14511332; 14514642; 14517215; 14530307; 145…
description: prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
database cross reference: Ensembl:ENSG00000073756
database cross reference: HGNC:9605
database cross reference: HPRD:02599
database cross reference: MIM:600262
database cross reference: Vega:OTTHUMG00000035473

PTPN1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PTP1B
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PTPN1
full name from nomenclature authority: protein tyrosine phosphatase, non-receptor type 1
NCBI GeneID: 5770
gene map location: 20q13.1-q13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004725 (EC: IDA, PMID: 18074158); GO_0004725 (EC: TAS); GO_0005158 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10660596); GO_0005769 (EC: IDA); GO_0005783 (EC: IDA); GO_0005789 (EC: IEA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, Qualifier: colocalizes_with); GO_0007596 (EC: TAS); GO_0008270 (EC: IDA, PMID: 18074158); GO_0008286 (EC: IEA); GO_0009966 (EC: IMP); GO_0019221 (EC: TAS); GO_0019899 (EC: IPI); GO_0019901 (EC: IPI); GO_0030100 (EC: IDA); GO_0030168 (EC: TAS); GO_0030968 (EC: IDA); GO_0030971 (EC: IPI, PMID: 18819921); GO_0031410 (EC: IEA); GO_0031532 (EC: IMP); GO_0035335 (EC: IDA); GO_0035335 (EC: IMP, PMID: 14966296); GO_0035791 (EC: IMP, PMID: 14966296); GO_0044822 (EC: IDA); GO_0046627 (EC: NAS, PMID: 11742412); GO_0046875 (EC: IPI); GO_0060333 (EC: TAS); GO_0060334 (EC: TAS); GO_0060337 (EC: TAS); GO_0060338 (EC: TAS); GO_0060397 (EC: TAS); GO_1902202 (EC: IMP, PMID: 18819921)
has PubMed association: PMID: 1739967; 2157211; 2164224; 2546149; 7510677; 7514173; 7539106; 7540771; 7544790; 7545675; 7693694; 7935344; 8128219; 8389479; 8491187; 8621392; 8647855; 8826975; 8940099; 8940134; 8999839; 9261115; 9355745; 9391040; 9407132; 9418872; 9499405; 9553104; 9566916; 9600099; 9922143; 10350489; 10480872; 10660596; 10748206; 10889023; 10940933; 11007774; 11106648; 11136729; 11163213; 11316810; 11506178; 11579209; 11694501; 11703427; 11726652; 11742412; 11756316; 11780052; 11788587; 11833006; 11836311; 12082107; 12176037; 12237455; 12354677; 12365558; 12377785; 12388170; 12414790; 12424235; 12446583; 12468645; 12477932; 12504077; 12547827; 12554649; 12573287; 12634852; 12802338; 12802339; 12857726; 12907755; 14514610; 14722096; 14966296; 14976221; 15031294; 15039022; 15097232; 15189365; 15235769; 15258570; 15489334; 15504984; 15504985; 15588985; 15592455; 15715684; 15737620; 15821101; 15866871; 15894168; 15919813; 15919835; 15998263; 16005629; 16115959; 16249458; 16289152; 16291744; 16344560; 16407290; 16505227; 16582879; 16644720; 16652382; 16677372; 16713994; 17056636; 17081112; 17081983; 17092689; 17135270; 17159996; 17185494; 17240976; 17255364; 17333110; 17339316; 17403124; 17509747; 17560463; 17634210; 17643420; 17974954; 18029348; 18074158; 18077048; 18253097; 18332219; 18387954; 18571728; 18636124; 18660489; 18716132; 18819921; 18840608; 18846048; 18854601; 18925540; 18957266; 19008309; 19167335; 19208619; 19435911; 19491387; 19578796; 19589142; 19782770; 19948975; 20000419; 20030748; 20059965; 20101100; 20118922; 20131294; 20177231; 20236928; 20388125; 20416077; 20467438; 20493809; 20504764; 20578946; 20601126; 20615878; 20627780; 20628624; 20682687; 20864346; 20871154; 20937240; 20952588; 21123182; 21139048; 21188419; 21411736; 21442314; 21487008; 21513978; 21632985; 21676396; 21707536; 21795709; 21849469; 21869483; 21906983; 21913686; 21959757; 21972092; 21988832; 22031842; 22045810; 22169477; 22282656; 22304920; 22404968; 22450318; 22474028; 22509299; 22609…
description: protein tyrosine phosphatase, non-receptor type 1
database cross reference: Ensembl:ENSG00000196396
database cross reference: HGNC:9642
database cross reference: HPRD:01477
database cross reference: MIM:176885
database cross reference: Vega:OTTHUMG00000032729

PVRL2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD112
alternative term: HVEB
alternative term: PRR2
alternative term: PVRR2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PVRL2
full name from nomenclature authority: poliovirus receptor-related 2 (herpesvirus entry mediator B)
NCBI GeneID: 5819
gene map location: 19q13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001618 (EC: IEA); GO_0001675 (EC: IEA); GO_0002860 (EC: IMP, PMID: 12913096); GO_0002891 (EC: IMP, PMID: 16831868); GO_0005515 (EC: IPI, PMID: 19011627); GO_0005886 (EC: TAS); GO_0005911 (EC: IDA, PMID: 9845526); GO_0005915 (EC: ISS, PMID: 10225955); GO_0007010 (EC: IEA); GO_0007156 (EC: IDA, PMID: 9845526); GO_0007165 (EC: TAS, PMID: 9657005); GO_0007286 (EC: ISS); GO_0007289 (EC: IEA); GO_0009566 (EC: IEA); GO_0009986 (EC: IDA, PMID: 16831868); GO_0015026 (EC: TAS, PMID: 9657005); GO_0016021 (EC: IDA, PMID: 12913096); GO_0019064 (EC: IDA, PMID: 12915581); GO_0030382 (EC: IEA); GO_0032990 (EC: IEA); GO_0033005 (EC: IMP, PMID: 16831868); GO_0034329 (EC: TAS); GO_0034332 (EC: TAS); GO_0042271 (EC: IMP, PMID: 12913096); GO_0042802 (EC: IPI); GO_0042803 (EC: IEA); GO_0042803 (EC: IPI, PMID: 9845526); GO_0044782 (EC: IEA); GO_0045216 (EC: TAS); GO_0045954 (EC: IMP, PMID: 16304049); GO_0046814 (EC: IDA, PMID: 12915581); GO_0050776 (EC: TAS); GO_0050839 (EC: IPI, PMID: 12913096); GO_0051654 (EC: IEA); GO_0051856 (EC: IDA, PMID: 12915581); GO_0060370 (EC: IDA, PMID: 15039383)
has PubMed association: PMID: 7622062; 9657005; 9683266; 9845526; 10196354; 10225955; 10520737; 10617658; 10627537; 10729168; 10733589; 11544254; 11602758; 11984219; 12011057; 12438620; 12477932; 12913096; 12915581; 15039383; 15146197; 15465608; 15489334; 15536144; 15607800; 15811349; 16169070; 16189514; 16304049; 16313259; 16344560; 16738668; 16740910; 16831868; 17081983; 17376543; 17534374; 17696193; 18823527; 19011627; 19478445; 19815499; 19913121; 20410314; 20572854; 20617580; 20628086; 20634891; 20662561; 20672350; 20885792; 21139048; 21383766; 21900206; 21906983; 21909109; 21982860; 21988832; 22005931; 22159054; 22927415; 23192594; 23326517; 23419831; 23465821; 23565137
description: poliovirus receptor-related 2 (herpesvirus entry mediator B)
database cross reference: Ensembl:ENSG00000130202
database cross reference: HGNC:9707
database cross reference: HPRD:02879
database cross reference: MIM:600798
database cross reference: Vega:OTTHUMG00000180839

RAC1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: Rac-1
alternative term: TC-25
alternative term: p21-Rac1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RAC1
full name from nomenclature authority: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
NCBI GeneID: 5879
NCBI LocusTag: MIG5
gene map location: 7p22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: IEA); GO_0001891 (EC: IEA); GO_0001934 (EC: IMP); GO_0002093 (EC: IEA); GO_0002551 (EC: IEA); GO_0003382 (EC: IEA); GO_0003924 (EC: TAS, PMID: 9312003); GO_0005515 (EC: IPI, PMID: 10051605); GO_0005525 (EC: IDA, PMID: 15467718); GO_0005802 (EC: IDA, PMID: 12915445); GO_0005829 (EC: ISS); GO_0005829 (EC: TAS); GO_0005886 (EC: TAS); GO_0006928 (EC: TAS, PMID: 9572733); GO_0006954 (EC: TAS, PMID: 9572733); GO_0006972 (EC: IEA); GO_0007155 (EC: TAS, PMID: 9572733); GO_0007160 (EC: NAS, PMID: 18156211); GO_0007264 (EC: IEA); GO_0007411 (EC: TAS); GO_0007596 (EC: TAS); GO_0008283 (EC: IEA); GO_0009611 (EC: TAS, PMID: 9572733); GO_0009653 (EC: TAS, PMID: 9572733); GO_0010310 (EC: TAS, PMID: 16636067); GO_0010592 (EC: IDA, PMID: 15467718); GO_0016020 (EC: ISS); GO_0016032 (EC: TAS); GO_0017137 (EC: IEA); GO_0019897 (EC: IEA); GO_0019899 (EC: IPI, PMID: 16636067); GO_0019901 (EC: IEA); GO_0021799 (EC: IEA); GO_0021831 (EC: IEA); GO_0030027 (EC: IEA); GO_0030032 (EC: IMP, PMID: 9312003); GO_0030036 (EC: IGI, PMID: 19890013); GO_0030041 (EC: TAS, PMID: 9312003); GO_0030168 (EC: TAS); GO_0030334 (EC: IMP, PMID: 19934221); GO_0030742 (EC: IEA); GO_0030838 (EC: IEA); GO_0031295 (EC: TAS); GO_0031529 (EC: IDA, PMID: 15467718); GO_0031529 (EC: TAS, PMID: 9312003); GO_0031996 (EC: IPI, PMID: 12612085); GO_0032587 (EC: IEA); GO_0032707 (EC: IDA, PMID: 16982892); GO_0034446 (EC: IEA); GO_0035025 (EC: TAS, PMID: 9312003); GO_0035556 (EC: TAS, PMID: 9572733); GO_0038095 (EC: TAS); GO_0038096 (EC: TAS); GO_0042470 (EC: IEA); GO_0043065 (EC: TAS); GO_0043552 (EC: IEA); GO_0043652 (EC: IEA); GO_0045087 (EC: TAS); GO_0045216 (EC: IEA); GO_0045453 (EC: IEA); GO_0045740 (EC: IEA); GO_0048011 (EC: TAS); GO_0048261 (EC: TAS, PMID: 9312003); GO_0048532 (EC: IEA); GO_0048813 (EC: IEA); GO_0048870 (EC: IDA, PMID: 19403692); GO_0050690 (EC: TAS); GO_0051022 (EC: ISS); GO_0051668 (EC: IMP, PMID: 16636067); GO_0060071 (EC: IEA); GO_0060263 (EC: IDA, PMID: 16636067); GO_0070062 (EC: ID…
has PubMed association: PMID: 1643658; 1903399; 2108320; 2550440; 2674130; 7493928; 7545969; 7629060; 7673236; 7738010; 7744004; 7744773; 7938008; 7957046; 8034624; 8036496; 8107774; 8491184; 8496137; 8543060; 8631991; 8643625; 8670801; 8670882; 8702968; 8756646; 8769096; 8798539; 8939933; 8990187; 8994833; 9030878; 9033596; 9079650; 9083043; 9139723; 9148763; 9190911; 9255350; 9305638; 9312003; 9417078; 9427749; 9463375; 9487125; 9490022; 9520479; 9535855; 9572733; 9582072; 9624165; 9642115; 9786927; 9799233; 9808620; 9843499; 9857026; 10051605; 10220378; 10346909; 10394361; 10486263; 10508610; 10523675; 10559471; 10597294; 10617634; 10648409; 10673424; 10706722; 10747961; 10766742; 10779525; 10802735; 10816584; 10821761; 10869570; 10871853; 10873802; 10947987; 10954424; 10958683; 11021801; 11027608; 11030651; 11035813; 11062023; 11084340; 11090627; 11101877; 11130063; 11130076; 11134022; 11135665; 11157984; 11163217; 11258927; 11260256; 11274357; 11278572; 11284700; 11287617; 11328862; 11346801; 11368848; 11416133; 11422783; 11431473; 11438723; 11457725; 11478794; 11513578; 11513579; 11590143; 11595749; 11604131; 11685227; 11756498; 11756552; 11822867; 11839748; 11884513; 11893732; 11896062; 11948427; 11950930; 11950936; 11955434; 11973651; 11998687; 12006387; 12027902; 12038964; 12054568; 12086876; 12110184; 12115629; 12117911; 12123608; 12134158; 12169092; 12181570; 12239215; 12376548; 12376551; 12377770; 12393431; 12393632; 12453877; 12454018; 12477932; 12499846; 12511425; 12524240; 12533515; 12538863; 12547822; 12574162; 12584113; 12606638; 12612085; 12650940; 12657628; 12676940; 12690205; 12714565; 12716910; 12719789; 12730235; 12761036; 12787561; 12810717; 12819203; 12853948; 12861025; 12874273; 12879077; 12883706; 12912997; 12915445; 12919680; 12944407; 12960245; 12972426; 14506233; 14514689; 14530271; 14557270; 14573547; 14576080; 14597672; 14623895; 14625275; 14641180; 14701795; 14702039; 14729058; 14736526; 14737186; 14764880; 14960575; 14976202; 15009099; 15023524; 15048733; 1…
description: ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
database cross reference: Ensembl:ENSG00000136238
database cross reference: HGNC:9801
database cross reference: HPRD:03627
database cross reference: MIM:602048
database cross reference: Vega:OTTHUMG00000023540

RAF1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CRAF
alternative term: NS5
alternative term: Raf-1
alternative term: c-Raf
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RAF1
full name from nomenclature authority: v-raf-1 murine leukemia viral oncogene homolog 1
NCBI GeneID: 5894
gene map location: 3p25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: TAS); GO_0000186 (EC: TAS); GO_0001666 (EC: IEA); GO_0004672 (EC: TAS, PMID: 8063729); GO_0004674 (EC: IDA, PMID: 19667065); GO_0004709 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10433554); GO_0005524 (EC: IEA); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA, PMID: 17724343); GO_0005737 (EC: ISS); GO_0005741 (EC: TAS, PMID: 8929532); GO_0005794 (EC: IPI, PMID: 17724343); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 17724343); GO_0005886 (EC: TAS); GO_0006468 (EC: TAS, PMID: 8063729); GO_0006915 (EC: TAS, PMID: 8929532); GO_0007165 (EC: TAS, PMID: 8063729); GO_0007173 (EC: TAS); GO_0007190 (EC: NAS, PMID: 15385642); GO_0007264 (EC: TAS); GO_0007265 (EC: TAS); GO_0007268 (EC: TAS); GO_0007411 (EC: TAS); GO_0007507 (EC: IEA); GO_0007596 (EC: TAS); GO_0008283 (EC: TAS, PMID: 8063729); GO_0008285 (EC: IDA, PMID: 9765203); GO_0008286 (EC: TAS); GO_0008543 (EC: TAS); GO_0030168 (EC: TAS); GO_0031143 (EC: IEA); GO_0031267 (EC: IPI, Qualifier: NOT, PMID: 12194967); GO_0031333 (EC: IDA, PMID: 19667065); GO_0031434 (EC: IEA); GO_0033138 (EC: IDA, PMID: 19667065); GO_0034220 (EC: TAS); GO_0035023 (EC: TAS, PMID: 16649144); GO_0038095 (EC: TAS); GO_0042060 (EC: TAS, PMID: 15943972); GO_0042802 (EC: IPI, PMID: 17979178); GO_0042981 (EC: TAS); GO_0043066 (EC: IDA, PMID: 19667065); GO_0043154 (EC: TAS); GO_0045087 (EC: TAS); GO_0045104 (EC: IEA); GO_0045595 (EC: TAS); GO_0046872 (EC: IEA); GO_0046982 (EC: IEA); GO_0048011 (EC: TAS); GO_0055085 (EC: TAS); GO_0071550 (EC: IEA); GO_1902042 (EC: IEA); GO_2000145 (EC: TAS)
has PubMed association: PMID: 1611909; 1612588; 1639773; 1846778; 2475255; 2955285; 2993863; 3003687; 3616625; 7477354; 7517401; 7523381; 7559537; 7628630; 7644510; 7730360; 7731720; 7744247; 7766599; 7782277; 7791872; 7862125; 7935795; 7939632; 7969158; 8035810; 8063729; 8084603; 8125298; 8157000; 8307946; 8321321; 8332187; 8332195; 8349614; 8349631; 8393135; 8394352; 8408024; 8530446; 8621729; 8628317; 8663231; 8692945; 8702721; 8710867; 8753867; 8756332; 8816460; 8876196; 8887682; 8889548; 8900182; 8910675; 8911690; 8929531; 8929532; 8939988; 8962087; 9001246; 9069260; 9069267; 9091312; 9099670; 9115221; 9144171; 9150145; 9153224; 9154803; 9230211; 9234708; 9261098; 9311917; 9315742; 9446616; 9488663; 9523700; 9553107; 9624170; 9632690; 9658081; 9671314; 9689060; 9710607; 9765203; 9808624; 9819434; 9823899; 9867809; 10064593; 10205168; 10329666; 10369681; 10373531; 10433554; 10454553; 10486249; 10497893; 10498616; 10523633; 10523642; 10531364; 10557073; 10576742; 10585452; 10611249; 10620507; 10712923; 10757792; 10783161; 10837247; 10848612; 10869570; 10882715; 10887173; 10922060; 10958680; 10969079; 11005817; 11044439; 11171046; 11226259; 11231577; 11306563; 11325826; 11350735; 11409918; 11427728; 11447113; 11463741; 11520933; 11585916; 11585923; 11604401; 11676916; 11697890; 11733498; 11741534; 11751906; 11756411; 11784866; 11788587; 11853019; 11948406; 11969417; 11971957; 11997508; 12010819; 12079506; 12087097; 12127063; 12194967; 12237340; 12244094; 12360521; 12374792; 12379659; 12391160; 12429936; 12477932; 12488548; 12490852; 12551923; 12620389; 12626521; 12663662; 12682854; 12691824; 12717443; 12734410; 12774123; 12843393; 12851216; 12865432; 12925535; 12954639; 12975377; 14597674; 14623285; 14654780; 14654844; 14688025; 14724584; 14724641; 15031288; 15035987; 15041731; 15067053; 15075335; 15118098; 15122343; 15150271; 15211515; 15215316; 15302887; 15314064; 15385642; 15451031; 15459208; 15470083; 15485920; 15489334; 15520859; 15591313; 15618521; 15653554; 15657590; 15662129; 156…
description: v-raf-1 murine leukemia viral oncogene homolog 1
database cross reference: Ensembl:ENSG00000132155
database cross reference: HGNC:9829
database cross reference: HPRD:01265
database cross reference: MIM:164760
database cross reference: Vega:OTTHUMG00000129789

RARA
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NR1B1
alternative term: RAR
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RARA
full name from nomenclature authority: retinoic acid receptor, alpha
NCBI GeneID: 5914
gene map location: 17q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IEA); GO_0000790 (EC: IDA, PMID: 17363140); GO_0000900 (EC: IEA); GO_0001657 (EC: IEA); GO_0001889 (EC: IEA); GO_0001972 (EC: IDA, PMID: 2825025); GO_0003417 (EC: IEA); GO_0003700 (EC: IDA, PMID: 18922886); GO_0003707 (EC: IEA); GO_0003708 (EC: IDA, PMID: 2825025); GO_0003713 (EC: IDA); GO_0003713 (EC: IMP, PMID: 19917671); GO_0003714 (EC: IDA); GO_0005102 (EC: IDA, PMID: 19628791); GO_0005515 (EC: IPI, PMID: 16189514); GO_0005634 (EC: IDA, PMID: 18845237); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA, PMID: 19850744); GO_0006367 (EC: TAS); GO_0006468 (EC: IMP, PMID: 16456540); GO_0007165 (EC: IDA, PMID: 2825025); GO_0007281 (EC: IEA); GO_0007283 (EC: IEA); GO_0007565 (EC: IEA); GO_0008134 (EC: IPI, PMID: 17641689); GO_0008144 (EC: IEA); GO_0008270 (EC: IEA); GO_0008284 (EC: IMP); GO_0008285 (EC: IEA); GO_0009986 (EC: IC, PMID: 2825025); GO_0010467 (EC: TAS); GO_0014068 (EC: IEA); GO_0019899 (EC: IPI, PMID: 12039952); GO_0019904 (EC: IPI); GO_0030425 (EC: IEA); GO_0030520 (EC: IDA, PMID: 15831516); GO_0030850 (EC: IEA); GO_0030853 (EC: IDA, PMID: 19917671); GO_0031490 (EC: IDA, PMID: 19917671); GO_0031641 (EC: IEA); GO_0032355 (EC: IDA, PMID: 15831516); GO_0032526 (EC: IMP, PMID: 17538076); GO_0032689 (EC: IDA, PMID: 18416830); GO_0032720 (EC: IDA, PMID: 18416830); GO_0032736 (EC: IDA, PMID: 18416830); GO_0032753 (EC: IDA, PMID: 18416830); GO_0032754 (EC: IDA, PMID: 18416830); GO_0033189 (EC: IEA); GO_0034097 (EC: IEA); GO_0035014 (EC: IEA); GO_0035264 (EC: IEA); GO_0042981 (EC: IEA); GO_0043025 (EC: IEA); GO_0043277 (EC: IMP, PMID: 19628791); GO_0043422 (EC: IPI, PMID: 16417524); GO_0043565 (EC: IEA); GO_0044323 (EC: IDA, PMID: 19917671); GO_0045471 (EC: IEA); GO_0045630 (EC: IDA, PMID: 18416830); GO_0045666 (EC: IEA); GO_0045787 (EC: IMP); GO_0045892 (EC: IDA); GO_0045893 (EC: IDA, PMID: 18845237); GO_0045893 (EC: IMP, PMID: 19628791); GO_0045944 (EC: IDA, PMID: 19850744); GO_0045944 (EC: IMP); GO_0045947 (EC: IEA); GO_0046982 (EC: IDA, PMID: 19917671…
has PubMed association: PMID: 1310351; 1311253; 1314167; 1347744; 1652369; 2170850; 2175878; 2218500; 2825025; 2825036; 2899875; 7566114; 7566127; 7705655; 8051161; 8244378; 8302850; 8562957; 8598193; 8603043; 8616895; 8650544; 8887632; 9005841; 9115274; 9121466; 9192892; 9238002; 9256429; 9267036; 9288109; 9346901; 9380707; 9415406; 9430642; 9445475; 9486655; 9491782; 9531570; 9582446; 9628876; 9632709; 9642262; 9653119; 9717844; 9773978; 9795230; 9920895; 10022764; 10082574; 10207062; 10336495; 10337631; 10361124; 10428834; 10454579; 10480874; 10531331; 10567404; 10610177; 10611353; 10617585; 10698945; 10760302; 10786636; 10823961; 10860982; 10866662; 10872826; 10882070; 10882117; 10938104; 11014615; 11050004; 11106752; 11158331; 11274148; 11279242; 11331609; 11353774; 11358960; 11382777; 11439184; 11574675; 11812818; 11891284; 11929748; 11971969; 11980644; 12000751; 12009305; 12039952; 12048211; 12052862; 12060771; 12080444; 12101409; 12138096; 12193472; 12213824; 12235159; 12393611; 12399530; 12403842; 12420222; 12468549; 12477932; 12482873; 12503607; 12505266; 12549917; 12612084; 12665583; 12691149; 12805378; 12810556; 12835288; 12874288; 12935927; 12935958; 12943985; 14521715; 14559998; 14581481; 14592536; 14691372; 14702039; 14705796; 14737102; 15171703; 15246741; 15249124; 15254248; 15255287; 15308690; 15336696; 15337793; 15489334; 15528208; 15601827; 15604093; 15635645; 15670742; 15674337; 15729358; 15746941; 15808511; 15809060; 15831516; 15839736; 15870697; 15941852; 16085646; 16113082; 16179254; 16189514; 16203797; 16219912; 16239915; 16289102; 16311697; 16341674; 16344560; 16368877; 16417524; 16424870; 16432238; 16449642; 16456540; 16469706; 16480812; 16504291; 16540467; 16606617; 16630218; 16712791; 16713569; 16728697; 16769902; 16778766; 16797070; 17005281; 17195188; 17244680; 17252005; 17272513; 17272867; 17363140; 17451432; 17455211; 17456381; 17468032; 17475621; 17538076; 17560333; 17595318; 17611697; 17628022; 17641689; 17656367; 17712046; 17761950; 17943164; 17960617; 17…
description: retinoic acid receptor, alpha
database cross reference: HGNC:9864
database cross reference: HPRD:06769
database cross reference: MIM:180240

RELA
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NFKB3
alternative term: p65
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RELA
full name from nomenclature authority: v-rel avian reticuloendotheliosis viral oncogene homolog A
NCBI GeneID: 5970
gene map location: 11q13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001889 (EC: IEA); GO_0001942 (EC: IEA); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0003677 (EC: IDA, PMID: 15790681); GO_0003682 (EC: IDA, PMID: 19058135); GO_0003700 (EC: IDA, PMID: 12048232); GO_0003705 (EC: IDA, PMID: 3091258); GO_0005515 (EC: IPI, PMID: 10498867); GO_0005634 (EC: IDA, PMID: 15790681); GO_0005654 (EC: TAS); GO_0005667 (EC: IDA, PMID: 12048232); GO_0005737 (EC: IDA, PMID: 15790681); GO_0005829 (EC: IDA); GO_0005829 (EC: TAS); GO_0006117 (EC: IEA); GO_0006366 (EC: IDA, PMID: 3091258); GO_0006954 (EC: IDA, PMID: 12924514); GO_0006968 (EC: NAS, PMID: 8717528); GO_0007568 (EC: IEA); GO_0008134 (EC: IPI, PMID: 10849440); GO_0008284 (EC: IDA); GO_0009612 (EC: IEA); GO_0009887 (EC: IEA); GO_0010033 (EC: IDA, PMID: 10747850); GO_0010224 (EC: IDA, PMID: 15616591); GO_0014040 (EC: IEA); GO_0016032 (EC: IEA); GO_0019221 (EC: IDA, PMID: 15876188); GO_0019901 (EC: IPI, PMID: 10521409); GO_0031293 (EC: TAS); GO_0031625 (EC: IPI, PMID: 12748188); GO_0032332 (EC: IEA); GO_0032403 (EC: IEA); GO_0032481 (EC: TAS); GO_0032495 (EC: IEA); GO_0032570 (EC: IEA); GO_0032868 (EC: IEA); GO_0033590 (EC: IEA); GO_0033613 (EC: IPI, PMID: 15489227); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035666 (EC: TAS); GO_0038095 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042177 (EC: IEA); GO_0042301 (EC: IDA, PMID: 10521409); GO_0042493 (EC: IEA); GO_0042802 (EC: IDA, PMID: 9437432); GO_0042802 (EC: IPI, PMID: 10498867); GO_0043066 (EC: IDA, PMID: 10747850); GO_0043066 (EC: TAS); GO_0043123 (EC: IEP, PMID: 12761501); GO_0043200 (EC: IEA); GO_0043278 (EC: IEA); GO_0043565 (EC: IEA); GO_0044212 (EC: IDA, PMID: 17350185); GO_0045084 (EC: IEA); GO_0045087 (EC: TAS); GO_0045892 (EC: IDA, PMID: 17350185); GO_0045893 (EC: IDA, PMID: 17350185); GO_0045944 (EC: IDA, PMID: 17350185); GO_0045944 (EC: IMP, PMID: 10660609); GO_0046627 (EC: IEA); GO_0047485 (EC: …
has PubMed association: PMID: 1493333; 1505523; 1583734; 1732726; 1740106; 2001591; 2006423; 2050119; 3091258; 3140380; 7494249; 7628694; 7651415; 7659084; 7690421; 7706261; 7729429; 7739549; 7739562; 7800480; 7838536; 7859743; 7878004; 7886940; 7907305; 7933095; 8113688; 8139561; 8152812; 8188306; 8207793; 8246997; 8255759; 8281153; 8290595; 8413211; 8423996; 8428580; 8441377; 8543190; 8550813; 8615004; 8626413; 8627654; 8642313; 8649779; 8657102; 8670842; 8676466; 8709193; 8717528; 8724035; 8746784; 8798655; 8816457; 8834464; 8887627; 8887633; 8918464; 8978697; 9057089; 9096323; 9110146; 9150141; 9250404; 9252186; 9278385; 9315679; 9437432; 9468519; 9482849; 9510190; 9525916; 9548485; 9560267; 9566873; 9566883; 9570146; 9572494; 9584164; 9584180; 9659924; 9660950; 9722548; 9724652; 9730685; 9738011; 9751059; 9792375; 9806899; 9837938; 9865693; 9950430; 9990853; 10066434; 10075655; 10207088; 10225209; 10235267; 10336463; 10357819; 10384093; 10393859; 10400814; 10446807; 10480634; 10488148; 10490645; 10498867; 10521409; 10542237; 10542243; 10562553; 10580107; 10644332; 10644726; 10646849; 10660609; 10671224; 10671503; 10723127; 10747850; 10777532; 10777610; 10799874; 10839990; 10847592; 10849440; 10903762; 10928981; 10935546; 10938077; 10958685; 10995388; 11020244; 11044099; 11114727; 11160671; 11231305; 11241736; 11274168; 11278855; 11287411; 11299302; 11313474; 11385624; 11387332; 11395507; 11511100; 11522182; 11526476; 11533489; 11564889; 11567019; 11579140; 11585920; 11590148; 11591705; 11684013; 11704662; 11739381; 11813986; 11827962; 11833470; 11880271; 11922866; 11931769; 11953203; 11964305; 11967310; 11970949; 11971907; 11976329; 11980335; 11983170; 12019209; 12027803; 12040027; 12040437; 12048232; 12052823; 12055073; 12057007; 12067985; 12077347; 12080470; 12134007; 12138131; 12167619; 12173051; 12181450; 12213807; 12244126; 12350227; 12377934; 12393603; 12398897; 12403783; 12419806; 12419817; 12427593; 12429528; 12444202; 12456660; 12473373; 12477932; 12482669; 12485413; 12493764…
description: v-rel avian reticuloendotheliosis viral oncogene homolog A
database cross reference: Ensembl:ENSG00000173039
database cross reference: HGNC:9955
database cross reference: HPRD:01241
database cross reference: MIM:164014
database cross reference: Vega:OTTHUMG00000166566

RHEB
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: RHEB2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RHEB
full name from nomenclature authority: Ras homolog enriched in brain
NCBI GeneID: 6009
gene map location: 7q36
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003924 (EC: TAS, PMID: 8206940); GO_0005515 (EC: IPI); GO_0005525 (EC: ISS); GO_0005681 (EC: IEA); GO_0005829 (EC: TAS); GO_0005886 (EC: IEA); GO_0007050 (EC: TAS); GO_0007165 (EC: TAS, PMID: 8661031); GO_0007264 (EC: IEA); GO_0008286 (EC: TAS); GO_0016020 (EC: TAS, PMID: 8206940); GO_0019003 (EC: IEA); GO_0019901 (EC: IEA); GO_0030425 (EC: IEA); GO_0032008 (EC: IMP); GO_0043025 (EC: IEA); GO_0046872 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 8206940; 8543055; 8661031; 8889548; 9001246; 9099708; 9130713; 9847074; 10924367; 11980706; 12477932; 12690205; 12771962; 12820960; 12842888; 12853948; 12869548; 12869586; 12906785; 14702039; 15150271; 15308774; 15340059; 15388940; 15489334; 15728574; 15755954; 15772076; 15775987; 15809305; 15809346; 15854902; 15878852; 15951850; 16006564; 16098514; 16344560; 16631613; 16803888; 16915281; 17018601; 17077083; 17470430; 17928295; 17991864; 18324915; 18521078; 18550814; 18650380; 18658153; 18708577; 18708578; 18842593; 18948269; 19056867; 19222999; 19570981; 19636822; 19838215; 20048149; 20053679; 20127734; 20354165; 20368287; 20375271; 20388784; 20554106; 20685651; 20732420; 20818424; 20837708; 21048031; 21135540; 21139048; 21163940; 21336308; 21412983; 21437936; 21784859; 21890473; 21906983; 21963094; 21988832; 23409921; 23863162
description: Ras homolog enriched in brain
database cross reference: Ensembl:ENSG00000106615
database cross reference: HGNC:10011
database cross reference: HPRD:03188
database cross reference: MIM:601293
database cross reference: Vega:OTTHUMG00000157330

RPS6KA1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HU-1
alternative term: MAPKAPK1A
alternative term: RSK
alternative term: RSK1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RPS6KA1
full name from nomenclature authority: ribosomal protein S6 kinase, 90kDa, polypeptide 1
NCBI GeneID: 6195
NCBI LocusTag: RP11-492M19.2
gene map location: 1p
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000287 (EC: IEA); GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004674 (EC: IDA, PMID: 10679322); GO_0005515 (EC: IPI); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA); GO_0005819 (EC: IEA); GO_0005829 (EC: TAS); GO_0007049 (EC: IEA); GO_0007165 (EC: TAS, PMID: 8141249); GO_0007268 (EC: TAS); GO_0007411 (EC: TAS); GO_0030307 (EC: TAS, PMID: 18813292); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035666 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0043027 (EC: IDA, PMID: 18402937); GO_0043066 (EC: IMP, PMID: 11684016); GO_0043154 (EC: IDA, PMID: 18402937); GO_0043555 (EC: TAS, PMID: 18813292); GO_0043620 (EC: TAS, PMID: 18813292); GO_0045087 (EC: TAS); GO_0045597 (EC: TAS, PMID: 18813292); GO_0045944 (EC: IMP); GO_0048011 (EC: TAS); GO_0051403 (EC: TAS); GO_2000491 (EC: IMP, PMID: 10679322)
has PubMed association: PMID: 1545823; 1545828; 8125298; 8141249; 8248197; 8413226; 8601309; 8630373; 8663493; 8688081; 8756728; 8939914; 9030586; 9214631; 9218456; 9261139; 9353277; 9381178; 9430688; 9528769; 9687510; 9721103; 9770464; 9829964; 9914500; 9915826; 10318869; 10469565; 10480933; 10521512; 10635333; 10648825; 10673502; 10679322; 10723127; 10753652; 10837486; 10880354; 10949026; 10980595; 11139588; 11160957; 11171059; 11175347; 11260258; 11297520; 11432835; 11500364; 11507039; 11551945; 11684016; 11861786; 11914378; 12019261; 12036856; 12080086; 12093745; 12213813; 12235136; 12393804; 12477932; 12569367; 12594221; 12618428; 12626518; 12832467; 12842905; 12897128; 12917345; 12917364; 14702039; 14709557; 15024086; 15073170; 15112576; 15117958; 15121878; 15206906; 15276183; 15342917; 15489334; 15615708; 15647351; 15757502; 15861136; 15905173; 15910284; 15929978; 16039586; 16213824; 16217014; 16223362; 16282323; 16341674; 16626623; 16710414; 16738324; 17081983; 17192257; 17512525; 17634259; 17965187; 18029348; 18084084; 18402937; 18450423; 18451027; 18722121; 18813292; 18950845; 19036157; 19150432; 19332537; 19470470; 19675165; 19716794; 19808666; 19913121; 20048145; 20304964; 20628086; 20849292; 21035469; 21044953; 21075852; 21139048; 21423205; 21501342; 21832046; 21890473; 21900206; 21906983; 21963094; 21987572; 22006917; 22031759; 22050627; 22246185; 22249268; 22357623; 22427657; 22505724; 22586265; 22674792; 22683790; 22863883; 22865467; 22939624; 23401857; 23455922; 24036112
description: ribosomal protein S6 kinase, 90kDa, polypeptide 1
database cross reference: Ensembl:ENSG00000117676
database cross reference: HGNC:10430
database cross reference: HPRD:03402
database cross reference: MIM:601684
database cross reference: Vega:OTTHUMG00000004003

RPS6KB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PS6K
alternative term: S6K
alternative term: S6K-beta-1
alternative term: S6K1
alternative term: STK14A
alternative term: p70 S6KA
alternative term: p70(S6K)-alpha
alternative term: p70-S6K
alternative term: p70-alpha
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RPS6KB1
full name from nomenclature authority: ribosomal protein S6 kinase, 70kDa, polypeptide 1
NCBI GeneID: 6198
gene map location: 17q23.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000082 (EC: IMP, PMID: 14673156); GO_0003009 (EC: IEA); GO_0004672 (EC: IDA, PMID: 17936702); GO_0004711 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12150926); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA, PMID: 19085255); GO_0005739 (EC: IDA, PMID: 17936702); GO_0005741 (EC: IEA); GO_0005829 (EC: TAS); GO_0006468 (EC: IDA, PMID: 19085255); GO_0006915 (EC: IEA); GO_0007165 (EC: TAS, PMID: 1922062); GO_0007281 (EC: IEA); GO_0007568 (EC: IEA); GO_0007584 (EC: IEA); GO_0007616 (EC: IEA); GO_0008286 (EC: TAS); GO_0009408 (EC: IEA); GO_0009611 (EC: IEA); GO_0009612 (EC: IEA); GO_0009636 (EC: IEA); GO_0009749 (EC: IEA); GO_0009986 (EC: IEA); GO_0014732 (EC: IEA); GO_0014878 (EC: IEA); GO_0014911 (EC: IEA); GO_0016477 (EC: IEA); GO_0030054 (EC: IEA); GO_0031929 (EC: IDA, PMID: 12150926); GO_0032496 (EC: IEA); GO_0033574 (EC: IEA); GO_0033762 (EC: IEA); GO_0034612 (EC: IEA); GO_0042277 (EC: IEA); GO_0042493 (EC: IEA); GO_0043005 (EC: IEA); GO_0043066 (EC: IMP, PMID: 17936702); GO_0043201 (EC: IEA); GO_0043491 (EC: IEA); GO_0045202 (EC: IEA); GO_0045471 (EC: IEA); GO_0045727 (EC: IMP, PMID: 18423201); GO_0045931 (EC: IMP, PMID: 14673156); GO_0045948 (EC: IMP, PMID: 16763566); GO_0046324 (EC: IEA); GO_0046627 (EC: IMP, PMID: 18952604); GO_0048015 (EC: TAS, PMID: 9445476); GO_0048471 (EC: IEA); GO_0048633 (EC: IEA); GO_0048661 (EC: IEA); GO_0051384 (EC: IEA); GO_0071363 (EC: IDA, PMID: 17936702); GO_2001237 (EC: IEA)
has PubMed association: PMID: 1922062; 8871403; 9271440; 9427642; 9445476; 9465032; 9653190; 9804755; 10089566; 10197603; 10200280; 10567431; 10601311; 10807185; 10971657; 10973943; 11013237; 11171059; 11279232; 11297520; 11331760; 11438723; 11500364; 11516946; 11733037; 11774034; 11853558; 11914378; 12014987; 12019261; 12023960; 12052877; 12054624; 12150925; 12150926; 12477932; 12529391; 12586835; 12604610; 12718876; 12733712; 12747804; 12759354; 12801526; 12869548; 14673156; 14679009; 14702039; 14709557; 15024086; 15028555; 15066126; 15071500; 15149849; 15158097; 15203190; 15236312; 15249583; 15304500; 15314020; 15319361; 15341740; 15342556; 15474452; 15533996; 15589845; 15623621; 15659381; 15692808; 15696579; 15723049; 15790787; 15809305; 15812314; 15843522; 15854902; 15896331; 15899889; 15905173; 15953364; 16049009; 16109716; 16183647; 16262259; 16286006; 16364302; 16407298; 16434552; 16469801; 16640565; 16715128; 16763566; 16810323; 16818690; 16826166; 16837165; 16839745; 16883576; 16895915; 16899564; 16914728; 16922504; 16931574; 16962100; 16964243; 17043309; 17045920; 17052453; 17053147; 17081983; 17255101; 17310252; 17336708; 17386266; 17427199; 17512525; 17569770; 17599906; 17604271; 17616691; 17622239; 17693255; 17908691; 17936702; 18025271; 18279656; 18423201; 18451027; 18461003; 18505677; 18565837; 18652687; 18660489; 18813808; 18829578; 18952604; 19065636; 19085255; 19112174; 19168580; 19240722; 19266162; 19285034; 19322201; 19553685; 19730801; 19801633; 19815051; 19864428; 19881535; 19889638; 19913121; 19914247; 19936974; 19953087; 19961954; 19995915; 20137651; 20157535; 20173664; 20187284; 20190034; 20374740; 20410302; 20423989; 20433920; 20459645; 20599538; 20599721; 20617335; 20628086; 20657550; 20731018; 20819778; 20932932; 20953835; 20961652; 21035469; 21048031; 21067588; 21071439; 21093473; 21184268; 21224254; 21228102; 21258406; 21289241; 21292829; 21297943; 21390332; 21397856; 21424608; 21440577; 21444676; 21460630; 21467264; 21536668; 21541441; 21561857; 21602892; 21…
description: ribosomal protein S6 kinase, 70kDa, polypeptide 1
database cross reference: Ensembl:ENSG00000108443
database cross reference: HGNC:10436
database cross reference: HPRD:10202
database cross reference: MIM:608938
database cross reference: Vega:OTTHUMG00000150642

RYR3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RYR3
full name from nomenclature authority: ryanodine receptor 3
NCBI GeneID: 6263
gene map location: 15q14-q15
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005219 (EC: ISS); GO_0005219 (EC: TAS, PMID: 19095005); GO_0005509 (EC: IEA); GO_0005516 (EC: IEA); GO_0006816 (EC: IMP, PMID: 9395096); GO_0006941 (EC: IEA); GO_0015278 (EC: IMP, PMID: 9395096); GO_0016021 (EC: ISS); GO_0030314 (EC: IEA); GO_0033017 (EC: ISS); GO_0033017 (EC: TAS); GO_0034220 (EC: TAS); GO_0048471 (EC: IEA); GO_0048763 (EC: IEA); GO_0051289 (EC: ISS); GO_0051481 (EC: IEA); GO_0055085 (EC: TAS); GO_0070588 (EC: ISS); GO_0071277 (EC: ISS); GO_0071286 (EC: ISS); GO_0071313 (EC: ISS); GO_0071318 (EC: ISS)
has PubMed association: PMID: 1320290; 7523185; 7556644; 8276408; 9384575; 9395096; 9515741; 9607712; 10508160; 11171121; 11598113; 12213830; 12354756; 12471029; 12565913; 14550562; 14702039; 14970260; 17110338; 18588595; 19009018; 19095005; 19096130; 19581603; 20009918; 20195357; 20201926; 20379614; 20424473; 20962236; 21139048; 21145461; 21531043; 21810988; 21881589; 22100703; 22627881; 22664477; 22948152; 23393343; 24024966; 24026422; 24211435; 24457600
description: ryanodine receptor 3

S100B
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NEF
alternative term: S100
alternative term: S100-B
alternative term: S100beta
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: S100B
full name from nomenclature authority: S100 calcium binding protein B
NCBI GeneID: 6285
gene map location: 21q22.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 21
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001726 (EC: IDA, PMID: 10913138); GO_0005509 (EC: NAS, PMID: 9519411); GO_0005515 (EC: IPI, PMID: 10913138); GO_0005576 (EC: TAS); GO_0005615 (EC: IEA); GO_0005634 (EC: IDA); GO_0005737 (EC: IDA, PMID: 10913138); GO_0005737 (EC: ISS); GO_0007409 (EC: TAS, PMID: 8202493); GO_0007417 (EC: TAS, PMID: 8202493); GO_0007611 (EC: ISS); GO_0007613 (EC: IEA); GO_0008270 (EC: ISS); GO_0008283 (EC: TAS, PMID: 8202493); GO_0008284 (EC: IEA); GO_0008360 (EC: IEA); GO_0042802 (EC: IPI, PMID: 10913138); GO_0042803 (EC: IDA, PMID: 10913138); GO_0042803 (EC: IPI, PMID: 9519411); GO_0043025 (EC: IEA); GO_0043065 (EC: IEA); GO_0043123 (EC: IDA, PMID: 15033494); GO_0043231 (EC: IDA); GO_0044548 (EC: IPI, PMID: 10913138); GO_0045087 (EC: TAS); GO_0048156 (EC: ISS); GO_0048168 (EC: IEA); GO_0048306 (EC: IDA, PMID: 10913138); GO_0048471 (EC: IDA, PMID: 12118070); GO_0048708 (EC: IEA); GO_0050786 (EC: IPI, PMID: 15033494); GO_0051384 (EC: IEA); GO_0051597 (EC: IEA); GO_0060291 (EC: IEA); GO_0071456 (EC: IEA); GO_2001015 (EC: IEA)
has PubMed association: PMID: 1998503; 2394738; 2530061; 2833519; 2964086; 3111527; 4031854; 6487634; 7566098; 7759097; 8202493; 8341667; 8701470; 8750867; 8894274; 9335118; 9519411; 9774336; 9883272; 9923610; 9925766; 10394361; 10399917; 10510252; 10531386; 10830953; 10876243; 10913138; 11264299; 11312263; 11527429; 11809917; 11888280; 11969402; 12042313; 12118070; 12351263; 12377780; 12469878; 12470955; 12477932; 12480931; 12490005; 12493777; 12505619; 12527118; 12569284; 12630517; 12636931; 12645009; 12746458; 12927678; 14530578; 14642437; 14661952; 14675567; 14699277; 14967825; 14997170; 15033494; 15178678; 15236402; 15257081; 15306236; 15489334; 15556616; 15670788; 15708543; 15781852; 15820773; 15840729; 16143320; 16189514; 16340181; 16511125; 16931519; 17008613; 17010455; 17020600; 17023485; 17043297; 17091777; 17199889; 17264538; 17348038; 17396138; 17408991; 17525977; 17536784; 17579612; 17624933; 17660747; 17661202; 17678654; 17705023; 17719207; 17726019; 17955279; 17984171; 17984926; 17984939; 18039581; 18173564; 18181515; 18193148; 18337650; 18384084; 18385926; 18445708; 18451356; 18454941; 18494933; 18552513; 18587628; 18596106; 18614943; 18706914; 18783450; 18805362; 18854308; 18939940; 18948614; 18982242; 19011512; 19042077; 19086053; 19103440; 19147496; 19183802; 19202335; 19205880; 19216510; 19220958; 19221847; 19229202; 19297317; 19307814; 19330775; 19468240; 19482672; 19487970; 19497163; 19505208; 19539717; 19558426; 19593677; 19636631; 19654082; 19671853; 19674846; 19705461; 19812958; 19910580; 19939849; 20036852; 20036866; 20042890; 20093730; 20105309; 20237496; 20351179; 20398908; 20437790; 20473040; 20509936; 20559426; 20581773; 20587415; 20591429; 20592382; 20604725; 20614004; 20628824; 20686797; 20708613; 20716661; 20947022; 20950652; 21034449; 21070816; 21079180; 21112154; 21144594; 21273622; 21293918; 21303299; 21311479; 21368691; 21376255; 21423669; 21447379; 21455324; 21458434; 21473859; 21487066; 21504113; 21553520; 21587126; 21601568; 21620650; 21628886; 21640…
description: S100 calcium binding protein B
database cross reference: HGNC:10500
database cross reference: HPRD:01505
database cross reference: MIM:176990

MAPK12
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ERK3
alternative term: ERK6
alternative term: P38GAMMA
alternative term: PRKM12
alternative term: SAPK-3
alternative term: SAPK3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAPK12
full name from nomenclature authority: mitogen-activated protein kinase 12
NCBI GeneID: 6300
gene map location: 22q13.33
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000287 (EC: IDA, PMID: 10508788); GO_0004674 (EC: IDA, PMID: 15850461); GO_0004707 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12761180); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005739 (EC: IEA); GO_0005829 (EC: TAS); GO_0006351 (EC: IEA); GO_0006355 (EC: IEA); GO_0006975 (EC: TAS, PMID: 10848581); GO_0007050 (EC: TAS, PMID: 10848581); GO_0007165 (EC: TAS, PMID: 8633070); GO_0007265 (EC: TAS); GO_0007517 (EC: TAS, PMID: 8633070); GO_0018105 (EC: IDA, PMID: 15850461); GO_0042692 (EC: TAS); GO_0045445 (EC: IDA, PMID: 8633070); GO_0048011 (EC: TAS); GO_0051149 (EC: TAS)
has PubMed association: PMID: 1330687; 7566346; 8633070; 8920915; 9019171; 9169156; 9199504; 9297626; 9353289; 9564043; 9565682; 9628874; 9735171; 9771888; 9832145; 10212242; 10508788; 10567720; 10591208; 10848581; 11062067; 11062068; 11104762; 11181841; 11520933; 11741894; 11991731; 12167088; 12171600; 12226093; 12239168; 12387894; 12429732; 12477932; 12536241; 12761180; 12915405; 14592936; 14702039; 15123239; 15158451; 15284239; 15342622; 15461802; 15489334; 15850461; 15923648; 16637659; 17081983; 17088247; 17724032; 17906618; 18559936; 19251701; 19294699; 19913121; 19953087; 20332238; 20605917; 20628086; 20804750; 21044950; 21172807; 21532888; 21862636; 21878638; 21988832; 22399296; 22522454; 22730326; 22730327; 22939629; 23602568; 24250222
description: mitogen-activated protein kinase 12
database cross reference: Ensembl:ENSG00000188130
database cross reference: HGNC:6874
database cross reference: HPRD:03868
database cross reference: MIM:602399
database cross reference: Vega:OTTHUMG00000030145

ATXN1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ATX1
alternative term: D6S504E
alternative term: SCA1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ATXN1
full name from nomenclature authority: ataxin 1
NCBI GeneID: 6310
gene map location: 6p23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003677 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11001934); GO_0005634 (EC: IDA); GO_0005654 (EC: IDA, PMID: 12757932); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0006351 (EC: IEA); GO_0006396 (EC: NAS, PMID: 15615787); GO_0008022 (EC: IPI, PMID: 12757932); GO_0008219 (EC: IEA); GO_0008266 (EC: IDA, PMID: 11136710); GO_0008344 (EC: IEA); GO_0008542 (EC: IEA); GO_0016363 (EC: IDA, PMID: 17557114); GO_0034046 (EC: IDA, PMID: 11136710); GO_0042272 (EC: IDA, Qualifier: colocalizes_with, PMID: 15615787); GO_0042326 (EC: IEA); GO_0042405 (EC: IDA, PMID: 15615787); GO_0042802 (EC: IPI, PMID: 11001934); GO_0043231 (EC: IDA); GO_0043569 (EC: IEA); GO_0043621 (EC: IDA, PMID: 9097953); GO_0045892 (EC: IDA, PMID: 15016912); GO_0045944 (EC: IEA); GO_0051168 (EC: IDA, PMID: 15615787); GO_0060079 (EC: IEA)
has PubMed association: PMID: 1582256; 7647801; 7951322; 8358429; 8619528; 8634720; 8872471; 9097953; 9353120; 9353121; 10713882; 11001934; 11121205; 11136710; 11781699; 11804332; 11807410; 11973625; 12062018; 12093161; 12360291; 12411613; 12477932; 12659632; 12741986; 12757707; 12757932; 14574404; 14583607; 14756671; 14985428; 15016912; 15148151; 15167689; 15292212; 15300851; 15342556; 15615787; 15750336; 15824120; 15878393; 16121196; 16311891; 16380905; 16389595; 16497448; 16614004; 16713569; 16831871; 16967484; 17110330; 17127076; 17190598; 17442486; 17557114; 17646162; 17925862; 18029348; 18160752; 18166084; 18182848; 18216249; 18231590; 18337722; 18439907; 18519031; 19049837; 19208651; 19235102; 19259763; 19451621; 19500214; 19597981; 20018885; 20069235; 20097758; 20132795; 20220018; 20301363; 20308783; 20379614; 20477910; 20936779; 21302343; 21315774; 21475249; 21835928; 22330095; 22491195; 22511762; 22666429; 22780124; 22916034; 23197749; 23275563; 23294540; 23377640; 23528090; 23536093; 23634774; 23719381; 23760502; 24326307
description: ataxin 1
database cross reference: Ensembl:ENSG00000124788
database cross reference: HGNC:10548
database cross reference: HPRD:03333
database cross reference: MIM:601556
database cross reference: Vega:OTTHUMG00000014303

CCL2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GDCF-2
alternative term: HC11
alternative term: HSMCR30
alternative term: MCAF
alternative term: MCP-1
alternative term: MCP1
alternative term: SCYA2
alternative term: SMC-CF
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCL2
full name from nomenclature authority: chemokine (C-C motif) ligand 2
NCBI GeneID: 6347
gene map location: 17q11.2-q12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: IMP); GO_0001525 (EC: TAS, PMID: 18334747); GO_0001666 (EC: IEA); GO_0001938 (EC: IEA); GO_0002548 (EC: IDA, PMID: 12207323); GO_0004672 (EC: TAS, PMID: 9973507); GO_0005102 (EC: TAS, PMID: 10542238); GO_0005576 (EC: IDA); GO_0005576 (EC: TAS); GO_0005615 (EC: IEA); GO_0005737 (EC: IEA); GO_0006468 (EC: TAS, PMID: 9670957); GO_0006874 (EC: IEA); GO_0006935 (EC: TAS, PMID: 10623817); GO_0006954 (EC: IDA); GO_0006959 (EC: TAS, PMID: 9548499); GO_0006987 (EC: TAS); GO_0007010 (EC: IDA, PMID: 10072545); GO_0007155 (EC: TAS, PMID: 10198043); GO_0007165 (EC: NAS, PMID: 10770925); GO_0007166 (EC: TAS, PMID: 9548499); GO_0007179 (EC: IEA); GO_0007186 (EC: TAS, PMID: 10542238); GO_0007187 (EC: TAS, PMID: 10770925); GO_0007259 (EC: TAS, PMID: 9670957); GO_0007568 (EC: IEA); GO_0008009 (EC: IEA); GO_0008201 (EC: IEA); GO_0008360 (EC: IDA, PMID: 10072545); GO_0009408 (EC: IEA); GO_0009612 (EC: IEA); GO_0009617 (EC: IEP, PMID: 16034137); GO_0009887 (EC: TAS, PMID: 9364936); GO_0010332 (EC: IEA); GO_0010574 (EC: IEA); GO_0010759 (EC: IEA); GO_0014823 (EC: IEA); GO_0016525 (EC: IEA); GO_0019079 (EC: TAS, PMID: 10985244); GO_0019221 (EC: IDA, PMID: 12207323); GO_0019725 (EC: TAS, PMID: 18334747); GO_0030593 (EC: IEA); GO_0030968 (EC: TAS); GO_0031100 (EC: IEA); GO_0031663 (EC: IDA); GO_0031727 (EC: ISS); GO_0031727 (EC: TAS, PMID: 18021937); GO_0032570 (EC: IEA); GO_0033552 (EC: IEA); GO_0034351 (EC: IDA, PMID: 12753088); GO_0035684 (EC: ISS); GO_0042493 (EC: IEA); GO_0043025 (EC: IEA); GO_0043200 (EC: IEA); GO_0043491 (EC: IMP); GO_0043524 (EC: IDA, PMID: 12753088); GO_0043615 (EC: IDA, PMID: 12271471); GO_0044267 (EC: TAS); GO_0044344 (EC: IEP, PMID: 9407497); GO_0045471 (EC: IEA); GO_0046677 (EC: IEA); GO_0048010 (EC: IEA); GO_0048246 (EC: IDA, PMID: 12207323); GO_0048247 (EC: IEA); GO_0050806 (EC: IEA); GO_0050870 (EC: ISS); GO_0051384 (EC: IEA); GO_0051770 (EC: ISS); GO_0060137 (EC: IEA); GO_0070098 (EC: IEA); GO_0071222 (EC: ISS); GO_0071346 (EC: IEP, PMID: 94…
has PubMed association: PMID: 1661560; 1857712; 2004761; 2071154; 2322286; 2357211; 2465924; 2501656; 2513477; 2518726; 2648385; 2923622; 7545673; 7651403; 8051410; 8107690; 8195247; 8627182; 8631787; 8639605; 8642344; 8898111; 8989326; 9287323; 9364936; 9405404; 9407497; 9501225; 9548499; 9558113; 9670957; 9789057; 9792375; 9792674; 9837883; 9973507; 10068657; 10072545; 10198043; 10453044; 10477718; 10529171; 10542238; 10587439; 10623817; 10644332; 10706668; 10734104; 10751368; 10770925; 10918580; 10982368; 10985244; 11083865; 11145723; 11154208; 11313374; 11350939; 11500196; 11544456; 11750041; 11751881; 11776402; 11844145; 11878903; 11912219; 11929421; 11989790; 11999660; 12009356; 12022754; 12067898; 12078856; 12082252; 12089333; 12093796; 12117737; 12127997; 12149192; 12183528; 12186702; 12195705; 12204371; 12207323; 12234797; 12239249; 12271471; 12351486; 12358851; 12372466; 12374865; 12391099; 12391196; 12393171; 12397639; 12399623; 12408680; 12410798; 12413001; 12419245; 12443832; 12460032; 12462338; 12470469; 12473373; 12477932; 12485413; 12488502; 12505750; 12520153; 12520365; 12540965; 12632067; 12651071; 12665582; 12724308; 12753088; 12758167; 12787135; 12805068; 12826189; 12826377; 12846738; 12904997; 12944979; 12946945; 12957789; 12960255; 13679391; 14517168; 14517792; 14550782; 14571188; 14576080; 14597108; 14602575; 14620921; 14647058; 14651522; 14660607; 14687706; 14733721; 14767014; 15005768; 15016614; 15022320; 15033992; 15034225; 15041705; 15067078; 15077296; 15081318; 15082170; 15110609; 15115316; 15123743; 15135805; 15167690; 15188361; 15191525; 15191888; 15191916; 15194470; 15203564; 15226634; 15257681; 15280531; 15288699; 15296827; 15302103; 15308783; 15312962; 15349727; 15389752; 15466648; 15468376; 15481145; 15488313; 15489334; 15492853; 15529362; 15545821; 15579297; 15599324; 15602730; 15607028; 15611878; 15627719; 15630704; 15654958; 15677312; 15722361; 15740484; 15745922; 15780578; 15832427; 15848524; 15866653; 15880317; 15883814; 15900302; 15919935; 15976326; …
description: chemokine (C-C motif) ligand 2
database cross reference: Ensembl:ENSG00000108691
database cross reference: HGNC:10618
database cross reference: HPRD:01149
database cross reference: MIM:158105
database cross reference: Vega:OTTHUMG00000132887

SDC2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD362
alternative term: HSPG
alternative term: HSPG1
alternative term: SYND2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SDC2
full name from nomenclature authority: syndecan 2
NCBI GeneID: 6383
gene map location: 8q22-q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001523 (EC: TAS); GO_0001666 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11356864); GO_0005796 (EC: TAS); GO_0005886 (EC: TAS); GO_0005975 (EC: TAS); GO_0006024 (EC: TAS); GO_0006027 (EC: TAS); GO_0007603 (EC: TAS); GO_0008092 (EC: IEA); GO_0008150 (EC: ND); GO_0016021 (EC: IEA); GO_0030165 (EC: IPI, PMID: 18256285); GO_0030198 (EC: TAS); GO_0030203 (EC: TAS); GO_0030204 (EC: TAS); GO_0031000 (EC: IEA); GO_0042060 (EC: IEA); GO_0043025 (EC: IEA); GO_0043202 (EC: TAS); GO_0044281 (EC: TAS); GO_0048813 (EC: IEA); GO_0048814 (EC: ISS)
has PubMed association: PMID: 1315572; 2523388; 2745554; 2948951; 7524669; 7551962; 7690138; 8157651; 8187643; 8570206; 8832397; 8889549; 8997243; 9111037; 9244383; 9259269; 9342064; 9391086; 9660868; 9869645; 10375199; 10446183; 10497173; 10704377; 10734053; 10772816; 11018053; 11023673; 11024024; 11161813; 11356864; 11373281; 11567105; 11580899; 12036876; 12055189; 12200971; 12477932; 12676536; 12708751; 12860416; 12860968; 12885232; 14527339; 14674716; 14702039; 14976204; 14999018; 15183101; 15297422; 15489334; 15846369; 15936998; 16157597; 16253987; 16303743; 16440330; 16817962; 16982797; 16997272; 17035092; 17261577; 17457918; 17516498; 17623663; 18032547; 18093920; 18256285; 18342939; 18599487; 18716610; 19073173; 19086053; 19179614; 19288017; 19322201; 19383343; 19450993; 19641225; 19786981; 19822079; 19913121; 19962968; 20006588; 20379614; 20485444; 20628086; 20683009; 20929862; 21036168; 21139048; 21148276; 21289173; 21317913; 21482826; 21569759; 21813734; 21963094; 21987572; 21988832; 22170634; 22227189; 22238310; 22437834; 22471946; 22493442; 22550000; 22558273; 22745764; 22881146; 23000965; 23297089; 23333331; 23455922; 23736812; 23747112
description: syndecan 2
database cross reference: Ensembl:ENSG00000169439
database cross reference: HGNC:10659
database cross reference: HPRD:00803
database cross reference: MIM:142460
database cross reference: Vega:OTTHUMG00000164689

MAP2K4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: JNKK
alternative term: JNKK1
alternative term: MAPKK4
alternative term: MEK4
alternative term: MKK4
alternative term: PRKMK4
alternative term: SAPKK-1
alternative term: SAPKK1
alternative term: SEK1
alternative term: SERK1
alternative term: SKK1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAP2K4
full name from nomenclature authority: mitogen-activated protein kinase kinase 4
NCBI GeneID: 6416
gene map location: 17p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002224 (EC: TAS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004672 (EC: TAS, PMID: 7716521); GO_0004674 (EC: IEA); GO_0004713 (EC: IEA); GO_0005515 (EC: IPI, PMID: 9808624); GO_0005524 (EC: IEA); GO_0005634 (EC: IEA); GO_0005829 (EC: TAS); GO_0006915 (EC: IEA); GO_0007165 (EC: TAS, PMID: 7716521); GO_0007254 (EC: TAS); GO_0008545 (EC: IEA); GO_0031435 (EC: IEA); GO_0032839 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035666 (EC: TAS); GO_0038095 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0043204 (EC: IEA); GO_0043525 (EC: IEA); GO_0045087 (EC: TAS); GO_0045740 (EC: IEA); GO_0051403 (EC: TAS); GO_0071260 (EC: IEP, PMID: 19593445); GO_0072709 (EC: IEA)
has PubMed association: PMID: 7716521; 7839144; 7997270; 8631303; 8755474; 8786147; 9002521; 9006895; 9162092; 9182538; 9207092; 9331070; 9405400; 9582321; 9622070; 9661668; 9712898; 9761781; 9808624; 9841871; 10187804; 10489373; 10521444; 10523642; 10620019; 10713157; 10715136; 10969079; 11062067; 11090355; 11104681; 11279118; 11306453; 11562357; 11707464; 11754110; 11836244; 12189133; 12220515; 12223490; 12228228; 12368275; 12391307; 12429732; 12456688; 12477932; 12556533; 12659851; 12714585; 12730213; 12788955; 13130464; 14500727; 14504284; 14511403; 14581471; 14661062; 14702039; 14716300; 15256484; 15258908; 15262961; 15276183; 15299005; 15299019; 15328343; 15496400; 15592684; 15623633; 15670787; 15737736; 15866172; 15911620; 15998799; 16167336; 16197369; 16339111; 16344560; 16388335; 16472679; 16533805; 16627982; 16709574; 16802349; 16964394; 17009014; 17110930; 17158870; 17178861; 17322004; 17389591; 17541429; 17675521; 17906693; 18337456; 18408005; 18436711; 18713996; 19001375; 19012245; 19265040; 19294699; 19302196; 19351724; 19351817; 19513509; 19593445; 19610067; 19638505; 19737936; 19782076; 19861690; 20156194; 20309881; 20554746; 20732303; 20801953; 21030692; 21048031; 21333379; 21372598; 21487811; 21518142; 21575258; 21638028; 21702039; 21822214; 21832049; 21896780; 21900206; 21915030; 21925502; 21988832; 22154052; 22154358; 22158075; 22335172; 22366412; 22526163; 22535895; 22730327; 22828509; 22952603; 23299404; 23355465; 23653187; 23877919; 23921907; 23960075
description: mitogen-activated protein kinase kinase 4
database cross reference: Ensembl:ENSG00000065559
database cross reference: HGNC:6844
database cross reference: HPRD:03213
database cross reference: MIM:601335
database cross reference: Vega:OTTHUMG00000178267

SET
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: 2PP2A
alternative term: I2PP2A
alternative term: IGAAD
alternative term: IPP2A2
alternative term: PHAPII
alternative term: TAF-I
alternative term: TAF-IBETA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SET
full name from nomenclature authority: SET nuclear oncogene
NCBI GeneID: 6418
NCBI LocusTag: RP11-216B9.3
gene map location: 9q34
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000278 (EC: TAS); GO_0003677 (EC: IEA); GO_0004864 (EC: TAS, PMID: 8626647); GO_0005515 (EC: IPI, PMID: 11909973); GO_0005634 (EC: IDA, PMID: 11555662); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA, PMID: 11909973); GO_0005783 (EC: IDA, PMID: 11555662); GO_0005829 (EC: IEA); GO_0006260 (EC: TAS, PMID: 7753797); GO_0006334 (EC: IEA); GO_0006337 (EC: TAS, PMID: 11555662); GO_0006913 (EC: NAS, PMID: 11555662); GO_0008601 (EC: TAS, PMID: 11555662); GO_0010467 (EC: TAS); GO_0016070 (EC: TAS); GO_0016071 (EC: TAS); GO_0035067 (EC: TAS, PMID: 11555662); GO_0042393 (EC: TAS, PMID: 11555662); GO_0043086 (EC: TAS, PMID: 8626647); GO_0043234 (EC: IDA, PMID: 11909973); GO_0043524 (EC: IGI, PMID: 18374643); GO_0045892 (EC: IDA, PMID: 19343227); GO_0048471 (EC: IDA, PMID: 11555662); GO_0050790 (EC: TAS, PMID: 11555662)
has PubMed association: PMID: 1630450; 7753797; 8125298; 8131851; 8192856; 8294483; 8626647; 9353299; 9773788; 10390352; 10490631; 11018049; 11073993; 11076863; 11163245; 11231286; 11555662; 11741927; 11909973; 11978794; 12107410; 12407107; 12444089; 12477932; 12524539; 12628186; 14612398; 14671643; 14759373; 15100215; 15136563; 15146197; 15164053; 15173575; 15239126; 15342556; 15489334; 15489336; 15556635; 15592452; 15642345; 15840729; 15930275; 15931263; 16061203; 16162853; 16189514; 16212417; 16226712; 16286244; 16381901; 16474839; 16541025; 16712791; 16818237; 16823850; 16861234; 16916647; 17008916; 17034827; 17065150; 17081983; 17142970; 17245428; 17296573; 17309103; 17353931; 17360516; 17529993; 17608644; 17620317; 17643375; 17868381; 17875674; 18096310; 18299449; 18374643; 18457437; 18591933; 18649364; 18685082; 18781797; 18809386; 18931446; 19028839; 19059912; 19166587; 19234487; 19322201; 19343227; 19358706; 19471022; 19615732; 19738201; 19836239; 19900756; 20195357; 20360068; 20634891; 20693670; 20800572; 20876349; 21044950; 21139048; 21156847; 21209461; 21289314; 21319273; 21419339; 21515671; 21693764; 21720744; 21725597; 21800051; 21806989; 21844565; 21890473; 21906983; 21911363; 21940793; 21963094; 21987572; 21988832; 22053931; 22127260; 22133779; 22143534; 22174317; 22466417; 22505724; 22677993; 22739068; 22796192; 22863883; 22939629; 23000965; 23106910; 23134341; 23195690; 23233674; 23251465; 23374587; 23463506; 23568457; 23667531; 23691099; 23862649; 24144296; 24244333; 24250222
description: SET nuclear oncogene
database cross reference: Ensembl:ENSG00000119335
database cross reference: HGNC:10760
database cross reference: HPRD:09023
database cross reference: MIM:600960
database cross reference: Vega:OTTHUMG00000020755

SHC1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SHC
alternative term: SHCA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SHC1
full name from nomenclature authority: SHC (Src homology 2 domain containing) transforming protein 1
NCBI GeneID: 6464
NCBI LocusTag: RP11-307C12.1
gene map location: 1q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000165 (EC: IDA, PMID: 14676841); GO_0000187 (EC: IDA, PMID: 14676841); GO_0001525 (EC: IEA); GO_0004713 (EC: TAS); GO_0005068 (EC: TAS, PMID: 14676841); GO_0005154 (EC: ISS); GO_0005158 (EC: IPI, PMID: 7537849); GO_0005159 (EC: IPI, PMID: 7541045); GO_0005168 (EC: IPI, PMID: 15488758); GO_0005515 (EC: IPI, PMID: 11827484); GO_0005543 (EC: TAS, PMID: 14676841); GO_0005759 (EC: IEA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 14676841); GO_0005886 (EC: TAS); GO_0006987 (EC: TAS); GO_0007173 (EC: TAS); GO_0007176 (EC: TAS, PMID: 1623525); GO_0007265 (EC: TAS); GO_0007507 (EC: IEA); GO_0007596 (EC: TAS); GO_0008284 (EC: NAS, PMID: 14676841); GO_0008286 (EC: ISS); GO_0008286 (EC: TAS); GO_0008543 (EC: TAS); GO_0016337 (EC: IEA); GO_0018108 (EC: TAS); GO_0030168 (EC: TAS); GO_0030968 (EC: TAS); GO_0031532 (EC: IEA); GO_0038095 (EC: TAS); GO_0040008 (EC: IEA); GO_0044267 (EC: TAS); GO_0045087 (EC: TAS); GO_0045740 (EC: ISS); GO_0046875 (EC: IPI, PMID: 12925710); GO_0048011 (EC: TAS); GO_0050900 (EC: TAS); GO_0070435 (EC: ISS)
has PubMed association: PMID: 1623525; 7473762; 7499194; 7506413; 7514169; 7515480; 7516469; 7518560; 7520523; 7524086; 7535773; 7537361; 7537740; 7537849; 7541035; 7541045; 7542991; 7544002; 7544443; 7556090; 7559478; 7559507; 7635484; 7650013; 7657612; 7675451; 7731718; 7739560; 7791787; 7798267; 7806213; 7929214; 7933095; 7953556; 7961936; 7970715; 8035825; 8084588; 8112292; 8125298; 8155326; 8183561; 8195171; 8226808; 8294403; 8400282; 8491186; 8493579; 8524391; 8541543; 8557643; 8577769; 8610109; 8617812; 8621719; 8626541; 8628261; 8631299; 8631894; 8633037; 8643566; 8643691; 8647288; 8656061; 8662733; 8662748; 8662998; 8702728; 8723348; 8761298; 8776723; 8810325; 8874179; 8887653; 8890167; 8918464; 8939605; 8940017; 8940081; 8943228; 8950973; 8995379; 9045663; 9045692; 9047383; 9047384; 9049300; 9058724; 9083103; 9096689; 9121430; 9122198; 9126968; 9129019; 9130710; 9148935; 9174053; 9192859; 9202037; 9209414; 9223670; 9233773; 9234717; 9325171; 9344843; 9346925; 9378963; 9388490; 9434624; 9446569; 9461587; 9488479; 9541596; 9544989; 9614102; 9617486; 9632636; 9659899; 9660480; 9660833; 9685404; 9690470; 9694850; 9710204; 9710588; 9716598; 9733714; 9741627; 9756944; 9804835; 9824671; 9837978; 9856458; 9872323; 9886492; 9927207; 10025673; 10037694; 10049786; 10080542; 10085134; 10086341; 10092678; 10194451; 10224114; 10319320; 10340378; 10382761; 10457218; 10477722; 10477741; 10482988; 10559276; 10570290; 10595738; 10602027; 10623845; 10629055; 10635327; 10650943; 10652211; 10662798; 10675333; 10681566; 10704825; 10708759; 10748054; 10749680; 10764799; 10783152; 10790433; 10803466; 10816433; 10822173; 10891441; 10896916; 10900203; 10921922; 10964917; 10971656; 10996427; 11027663; 11044453; 11071635; 11075717; 11094073; 11287610; 11302736; 11342545; 11349134; 11370743; 11408594; 11432829; 11505033; 11520933; 11533253; 11607835; 11694516; 11707390; 11707404; 11707405; 11714803; 11724572; 11773443; 11782427; 11825908; 11827484; 11854294; 11855827; 11877420; 11884411; 11884620; 11888936; …
description: SHC (Src homology 2 domain containing) transforming protein 1
database cross reference: Ensembl:ENSG00000160691
database cross reference: HGNC:10840
database cross reference: HPRD:02780
database cross reference: MIM:600560
database cross reference: Vega:OTTHUMG00000037295

ST8SIA1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GD3S
alternative term: SIAT8
alternative term: SIAT8-A
alternative term: SIAT8A
alternative term: ST8SiaI
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ST8SIA1
full name from nomenclature authority: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
NCBI GeneID: 6489
gene map location: 12p12.1-p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003828 (EC: IEA); GO_0005975 (EC: TAS, PMID: 8195250); GO_0006486 (EC: IEA); GO_0006688 (EC: TAS, PMID: 8195250); GO_0008284 (EC: IEA); GO_0008373 (EC: TAS, PMID: 8195250); GO_0016021 (EC: TAS, PMID: 8195250); GO_0030173 (EC: IEA); GO_0034605 (EC: IEA); GO_0097503 (EC: TAS, PMID: 8195250)
has PubMed association: PMID: 7901202; 7937974; 8058740; 8195250; 8631981; 8786103; 8889548; 9287216; 10766765; 11849746; 12477932; 12818424; 15175338; 15196944; 15319364; 15489334; 16120058; 16481330; 16862187; 17913261; 18261989; 18348864; 18612409; 18690648; 19125296; 19280063; 19335207; 19428123; 19956670; 20379614; 20708005; 20889649; 22885356; 23725790
description: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
database cross reference: Ensembl:ENSG00000111728
database cross reference: HGNC:10869
database cross reference: HPRD:03078
database cross reference: MIM:601123
database cross reference: Vega:OTTHUMG00000169098

PMEL
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: D12S53E
alternative term: ME20
alternative term: ME20-M
alternative term: ME20M
alternative term: P1
alternative term: P100
alternative term: PMEL17
alternative term: SI
alternative term: SIL
alternative term: SILV
alternative term: gp100
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PMEL
full name from nomenclature authority: premelanosome protein
NCBI GeneID: 6490
gene map location: 12q13-q14
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 15695812); GO_0005576 (EC: IEA); GO_0005789 (EC: IDA, PMID: 15695812); GO_0005794 (EC: IDA, PMID: 15695812); GO_0005886 (EC: TAS, PMID: 8179825); GO_0016021 (EC: IEA); GO_0032438 (EC: IDA, PMID: 11694580); GO_0032585 (EC: IDA, PMID: 11694580); GO_0042438 (EC: IEA); GO_0042470 (EC: IDA, PMID: 15096515)
has PubMed association: PMID: 1922059; 1924386; 2255914; 7519602; 8022805; 8179825; 8592076; 8617263; 8739560; 9176405; 9222283; 9586889; 9743519; 10504440; 11266471; 11549113; 11694580; 12135425; 12477932; 12643545; 12732614; 12819038; 12925214; 14632201; 14702039; 15001714; 15096515; 15489334; 15695812; 16344560; 16492709; 16516837; 16682408; 16704461; 16760433; 17081065; 17303571; 17625594; 17991747; 18029348; 18181974; 18337837; 18463683; 18552823; 18563784; 19017974; 19047044; 19666488; 19840945; 19884326; 20231267; 21106765; 21148556; 21247888; 21949659; 21993558; 21993592; 22092386; 22613716; 22951725; 23389629; 23452376; 23643172; 23754390
description: premelanosome protein
database cross reference: Ensembl:ENSG00000185664
database cross reference: HGNC:10880
database cross reference: HPRD:01117
database cross reference: MIM:155550
database cross reference: Vega:OTTHUMG00000170573

SKP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: EMC19
alternative term: OCP-II
alternative term: OCP2
alternative term: SKP1A
alternative term: TCEB1L
alternative term: p19A
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SKP1
full name from nomenclature authority: S-phase kinase-associated protein 1
NCBI GeneID: 6500
gene map location: 5q31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000082 (EC: TAS); GO_0000086 (EC: TAS); GO_0000278 (EC: TAS); GO_0004842 (EC: IDA); GO_0005515 (EC: IPI, PMID: 11099048); GO_0005654 (EC: TAS); GO_0005829 (EC: TAS); GO_0007219 (EC: TAS); GO_0016032 (EC: TAS); GO_0016567 (EC: IDA, PMID: 15103331); GO_0019005 (EC: IDA, PMID: 15103331); GO_0031145 (EC: TAS); GO_0031146 (EC: IDA, PMID: 15103331); GO_0031467 (EC: IDA); GO_0031519 (EC: IDA, Qualifier: colocalizes_with, PMID: 16943429); GO_0035518 (EC: IDA, PMID: 16943429); GO_0051437 (EC: TAS); GO_0051439 (EC: TAS)
has PubMed association: PMID: 7553852; 7558018; 8051045; 8530064; 8646875; 8706131; 8912791; 9031623; 9430629; 9636170; 9660940; 9663463; 9736735; 9827542; 9857061; 9858587; 9872132; 9990852; 10023660; 10066435; 10074433; 10228155; 10230406; 10230407; 10321728; 10508920; 10514433; 10531035; 10531037; 10559858; 10559916; 10644755; 10648623; 10713156; 10918611; 10973499; 11027288; 11099048; 11231585; 11245432; 11337588; 11359933; 11389839; 11483504; 11565034; 11585921; 11689688; 11717410; 11850407; 11956208; 11961546; 12117534; 12140560; 12165731; 12417738; 12477932; 12481031; 12504025; 12504026; 12609982; 12628165; 12665572; 12679038; 12684064; 12717421; 12746458; 12791267; 12820959; 12840033; 12904573; 12963825; 14603323; 14685242; 14702039; 14706645; 14743216; 14752276; 15070733; 15103331; 15109709; 15118074; 15145941; 15280393; 15342634; 15452136; 15456869; 15469821; 15469984; 15489334; 15635413; 15640526; 15772084; 15966899; 16009132; 16123585; 16169070; 16196087; 16275325; 16278047; 16357137; 16501598; 16503656; 16682006; 16705156; 16714087; 16759355; 16880511; 16943429; 16979657; 17081987; 17098746; 17205132; 17215248; 17274640; 17283138; 17290223; 17314511; 17353931; 17389369; 17389604; 17434132; 17463251; 17494702; 17569795; 17704768; 17998335; 18071316; 18094045; 18203720; 18239684; 18247557; 18284940; 18378770; 18426905; 18660753; 18775313; 18781797; 18784078; 18784254; 18809579; 18818696; 19061640; 19066453; 19159283; 19193609; 19270694; 19295130; 19322201; 19398581; 19471022; 19509332; 19615732; 19762596; 19762597; 19776120; 19786724; 19828458; 19933270; 19996097; 20041211; 20057081; 20160477; 20181953; 20181957; 20360068; 20379614; 20404110; 20473970; 20484041; 20668394; 20832730; 21139048; 21145461; 21169563; 21205095; 21249194; 21378169; 21402913; 21466614; 21565611; 21572392; 21572988; 21620836; 21640084; 21726808; 21757720; 21778237; 21890473; 21906983; 21915095; 21952639; 21963094; 21988832; 22053931; 22113614; 22190034; 22205206; 22205987; 22242598; 22268729; 22295074; 22…
description: S-phase kinase-associated protein 1
database cross reference: HGNC:10899
database cross reference: HPRD:03255
database cross reference: MIM:601434

SLC2A1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DYT17
alternative term: DYT18
alternative term: DYT9
alternative term: EIG12
alternative term: GLUT
alternative term: GLUT1
alternative term: GLUT1DS
alternative term: HTLVR
alternative term: PED
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SLC2A1
full name from nomenclature authority: solute carrier family 2 (facilitated glucose transporter), member 1
NCBI GeneID: 6513
gene map location: 1p34.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001939 (EC: IEA); GO_0005355 (EC: TAS, PMID: 9462754); GO_0005515 (EC: IPI, PMID: 18347014); GO_0005886 (EC: TAS); GO_0005901 (EC: IEA); GO_0005911 (EC: IEA); GO_0005975 (EC: TAS); GO_0006112 (EC: TAS); GO_0006461 (EC: IDA, PMID: 18347014); GO_0006766 (EC: TAS); GO_0006767 (EC: TAS); GO_0006970 (EC: IEA); GO_0008645 (EC: TAS); GO_0015758 (EC: TAS); GO_0016020 (EC: TAS, PMID: 3028891); GO_0016021 (EC: IEA); GO_0016323 (EC: IEA); GO_0019852 (EC: TAS); GO_0019900 (EC: IEA); GO_0030496 (EC: IDA, PMID: 15166316); GO_0030864 (EC: IDA, PMID: 18347014); GO_0033300 (EC: IEA); GO_0042149 (EC: IEA); GO_0042470 (EC: IEA); GO_0042802 (EC: IPI, PMID: 1429721); GO_0042910 (EC: IEA); GO_0043621 (EC: IDA, PMID: 18347014); GO_0044281 (EC: TAS); GO_0050796 (EC: TAS); GO_0055056 (EC: IEA); GO_0055085 (EC: TAS); GO_0070062 (EC: IDA); GO_0072562 (EC: IDA)
has PubMed association: PMID: 1429721; 2394733; 2834252; 3028891; 3170580; 3839598; 7798206; 7829101; 8619474; 8662691; 8839927; 9110174; 9153243; 9462754; 10086067; 10198040; 10227690; 10562431; 10655495; 10759149; 10980529; 11007796; 11136715; 11168944; 11231353; 11296192; 11425315; 11477169; 11603379; 11681785; 11747430; 11774318; 11836704; 11842083; 11920478; 11953883; 11991658; 12064911; 12086959; 12112827; 12122099; 12133004; 12145475; 12379105; 12379106; 12477932; 12554125; 12583599; 12673735; 12752470; 12849991; 12942120; 12969152; 14622599; 14674124; 14679154; 14688257; 14702039; 14757434; 14991538; 15073187; 15086844; 15147968; 15166316; 15331928; 15342556; 15454279; 15489334; 15502921; 15682272; 15709778; 15745834; 15767416; 15778389; 15823019; 15847702; 15924676; 15955807; 15967114; 16125330; 16126902; 16136514; 16142350; 16147855; 16169070; 16172126; 16195374; 16220828; 16273245; 16310037; 16344560; 16407180; 16443776; 16519917; 16681687; 16681688; 16800634; 16842248; 17020877; 17064664; 17071132; 17080242; 17081065; 17167225; 17192790; 17294670; 17387384; 17404017; 17442736; 17451637; 17452775; 17504522; 17554865; 17591274; 17611657; 17635959; 17727838; 17854396; 17991316; 18097583; 18172662; 18177733; 18191496; 18212354; 18227718; 18245775; 18246802; 18271924; 18290322; 18311082; 18324916; 18343752; 18347014; 18351386; 18387950; 18401196; 18410529; 18422279; 18451999; 18565734; 18577546; 18613291; 18614966; 18676680; 18695903; 18726700; 18764953; 18821326; 18948400; 18953257; 18973239; 18981181; 18987250; 18990414; 19016655; 19020718; 19020742; 19085834; 19142800; 19152396; 19166280; 19170196; 19173807; 19234439; 19286567; 19289587; 19292042; 19303158; 19304421; 19347605; 19366592; 19386788; 19420105; 19434538; 19449892; 19465749; 19471022; 19490621; 19533082; 19533890; 19536037; 19554504; 19569052; 19587357; 19619276; 19625176; 19630075; 19648108; 19648882; 19655166; 19681047; 19692168; 19709351; 19738201; 19798636; 19819644; 19822956; 19883765; 19948975; 19955252; 20030103…
description: solute carrier family 2 (facilitated glucose transporter), member 1
database cross reference: Ensembl:ENSG00000117394
database cross reference: HGNC:11005
database cross reference: HPRD:00683
database cross reference: MIM:138140
database cross reference: Vega:OTTHUMG00000007657

SLC2A3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GLUT3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SLC2A3
full name from nomenclature authority: solute carrier family 2 (facilitated glucose transporter), member 3
NCBI GeneID: 6515
gene map location: 12p13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005355 (EC: IEA); GO_0005886 (EC: TAS); GO_0005975 (EC: TAS); GO_0006766 (EC: TAS); GO_0006767 (EC: TAS); GO_0008645 (EC: TAS); GO_0015758 (EC: TAS); GO_0016021 (EC: IEA); GO_0019852 (EC: TAS); GO_0044281 (EC: TAS); GO_0055085 (EC: TAS); GO_0070062 (EC: IDA)
has PubMed association: PMID: 1417839; 1695905; 3170580; 7502272; 8457197; 9253355; 9477959; 10086067; 11991658; 12064911; 12112827; 12397394; 12477932; 12554125; 12583599; 14757434; 15123239; 15489334; 16049004; 16125330; 16136514; 16169070; 16303743; 17442736; 17559076; 17611657; 17920708; 18029348; 18172662; 18299470; 18401196; 18764953; 18802725; 18976975; 19261894; 19322201; 19536037; 19554504; 19659459; 19681047; 19782666; 19786962; 20308990; 20424473; 20428049; 20468064; 20599725; 20870738; 21890473; 21920790; 21963094; 21987572; 22000473; 22069254; 22113212; 22234467; 22265971; 22270867; 22645302; 22663547; 22706202; 22876317; 22901689; 22901702; 23341039; 23343953; 23720776; 23995067
description: solute carrier family 2 (facilitated glucose transporter), member 3
database cross reference: Ensembl:ENSG00000059804
database cross reference: HGNC:11007
database cross reference: HPRD:00686
database cross reference: MIM:138170
database cross reference: Vega:OTTHUMG00000133685

SLC2A4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GLUT4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SLC2A4
full name from nomenclature authority: solute carrier family 2 (facilitated glucose transporter), member 4
NCBI GeneID: 6517
gene map location: 17p13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005355 (EC: TAS, PMID: 2649253); GO_0005515 (EC: IPI, PMID: 19478182); GO_0005771 (EC: IEA); GO_0005886 (EC: IDA, PMID: 12556481); GO_0005886 (EC: TAS); GO_0005887 (EC: IEA); GO_0005905 (EC: IEA); GO_0005975 (EC: TAS); GO_0008645 (EC: TAS); GO_0009897 (EC: IDA, PMID: 14562105); GO_0010021 (EC: IEA); GO_0012505 (EC: ISS); GO_0012506 (EC: IDA, PMID: 14562105); GO_0015758 (EC: TAS, PMID: 12556481); GO_0016020 (EC: TAS, PMID: 2649253); GO_0030136 (EC: IDA, PMID: 19478182); GO_0030140 (EC: IEA); GO_0032593 (EC: IDA, PMID: 19590752); GO_0032593 (EC: ISS); GO_0032869 (EC: IDA, PMID: 12556481); GO_0042383 (EC: IEA); GO_0042593 (EC: IDA, PMID: 14562105); GO_0044281 (EC: TAS); GO_0045471 (EC: IEA); GO_0046323 (EC: NAS, PMID: 11742412); GO_0048471 (EC: IDA, PMID: 12556481); GO_0050873 (EC: IEA); GO_0055056 (EC: IEA); GO_0055085 (EC: TAS); GO_0061024 (EC: TAS); GO_0070062 (EC: IEA); GO_0071470 (EC: IEA)
has PubMed association: PMID: 1397719; 1521731; 1601840; 1756912; 1918382; 2568955; 2649253; 2656669; 7916714; 8300557; 9388492; 10068455; 10606624; 10655495; 11003568; 11217863; 11500317; 11742412; 11842083; 11994746; 12064911; 12079888; 12145475; 12467732; 12477932; 12556481; 12565902; 12583599; 12606502; 12631717; 12700047; 12716391; 12716734; 14562105; 14630949; 14747278; 15166000; 15182197; 15184360; 15247266; 15292352; 15334390; 15480742; 15489334; 15528266; 15731326; 15864539; 15992544; 16096283; 16213228; 16396496; 16497797; 16497805; 16647043; 16763099; 16787385; 16803853; 16966355; 17003346; 17035674; 17164432; 17220298; 17382906; 17448565; 17496362; 17611657; 17717074; 18056982; 18067156; 18184930; 18249389; 18299470; 18635880; 18660489; 18676680; 18713752; 18769028; 18778861; 19035854; 19170196; 19188436; 19219452; 19251038; 19286271; 19321702; 19328476; 19375584; 19389739; 19478182; 19549745; 19554504; 19590752; 19625176; 19648108; 19692168; 19885647; 19913121; 19948975; 19955252; 20103707; 20173759; 20352120; 20363751; 20406953; 20417083; 20501875; 20625434; 20628086; 20854370; 20965718; 21147915; 21187969; 21454505; 21454690; 21454697; 21468601; 21547502; 21604201; 21606541; 21645024; 21668369; 21757715; 21796809; 21883150; 21986508; 22114711; 22286219; 22297303; 22384078; 22403297; 22452979; 22488520; 22496345; 22663547; 22673408; 22971162; 22992739; 23072821; 23202124; 23239154; 23424197; 23546602; 23746177; 23800880; 24216110
description: solute carrier family 2 (facilitated glucose transporter), member 4
database cross reference: Ensembl:ENSG00000181856
database cross reference: HGNC:11009
database cross reference: HPRD:00688
database cross reference: MIM:138190
database cross reference: Vega:OTTHUMG00000102181

SMPD2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ISC1
alternative term: NSMASE
alternative term: NSMASE1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SMPD2
full name from nomenclature authority: sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
NCBI GeneID: 6610
NCBI LocusTag: RP5-919F19.2
gene map location: 6q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004767 (EC: IEA); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 9520418); GO_0005901 (EC: IEA); GO_0006665 (EC: TAS); GO_0006684 (EC: TAS, PMID: 9520418); GO_0006687 (EC: TAS); GO_0009612 (EC: IEA); GO_0044281 (EC: TAS); GO_0046513 (EC: IEA); GO_0046872 (EC: IEA); GO_0048011 (EC: TAS); GO_0097190 (EC: TAS)
has PubMed association: PMID: 8889548; 9520418; 10608884; 11238738; 11997500; 12477932; 12566438; 12676795; 14689449; 15013522; 15051724; 15175033; 15489334; 15509740; 16344560; 17207965; 17212982; 17272284; 17344303; 17449104; 18040843; 18391951; 19698806; 19817993; 19834535; 19913121; 20378749; 20448054; 20628086; 20836852; 21335555; 21906983; 22899568
description: sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
database cross reference: Ensembl:ENSG00000135587
database cross reference: HGNC:11121
database cross reference: HPRD:04608
database cross reference: MIM:603498
database cross reference: Vega:OTTHUMG00000015348

SNCA
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NACP
alternative term: PARK1
alternative term: PARK4
alternative term: PD1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SNCA
full name from nomenclature authority: synuclein, alpha (non A4 component of amyloid precursor)
NCBI GeneID: 6622
gene map location: 4q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000287 (EC: IDA, PMID: 11850416); GO_0001774 (EC: IEA); GO_0001921 (EC: IDA, PMID: 18980610); GO_0001933 (EC: IEA); GO_0001956 (EC: IEA); GO_0005504 (EC: IDA, Qualifier: NOT, PMID: 16687662); GO_0005507 (EC: IDA); GO_0005509 (EC: IDA, PMID: 11312271); GO_0005515 (EC: IPI, PMID: 11943812); GO_0005543 (EC: IEA); GO_0005576 (EC: TAS); GO_0005634 (EC: IDA, PMID: 12406186); GO_0005640 (EC: IEA); GO_0005737 (EC: IDA, PMID: 12406186); GO_0005739 (EC: IEA); GO_0005791 (EC: IEA); GO_0005794 (EC: IEA); GO_0005829 (EC: IDA, PMID: 8248242); GO_0005840 (EC: IEA); GO_0005886 (EC: IDA, PMID: 12958153); GO_0005938 (EC: IDA, PMID: 19157893); GO_0006631 (EC: IEA); GO_0006638 (EC: IEA); GO_0006644 (EC: IEA); GO_0006919 (EC: IDA); GO_0007006 (EC: IEA); GO_0007568 (EC: IEA); GO_0008017 (EC: IEA); GO_0008021 (EC: IEA); GO_0008198 (EC: IDA, PMID: 11850416); GO_0008270 (EC: IDA, PMID: 11850416); GO_0008344 (EC: IEA); GO_0010040 (EC: IDA, PMID: 11850416); GO_0010517 (EC: IDA, PMID: 15641770); GO_0010642 (EC: IDA, PMID: 12239163); GO_0014048 (EC: IEA); GO_0014059 (EC: TAS); GO_0015629 (EC: IDA, PMID: 17408955); GO_0016234 (EC: IDA); GO_0016491 (EC: IDA); GO_0019894 (EC: IPI, PMID: 16176937); GO_0019904 (EC: IEA); GO_0030054 (EC: IEA); GO_0030424 (EC: IDA, PMID: 12958153); GO_0030426 (EC: IDA, PMID: 12958153); GO_0030544 (EC: IPI, PMID: 18975920); GO_0031092 (EC: IDA, Qualifier: colocalizes_with, PMID: 12239163); GO_0031115 (EC: IDA); GO_0031623 (EC: IDA, PMID: 18980610); GO_0031648 (EC: IDA); GO_0032026 (EC: IDA, PMID: 11850416); GO_0032410 (EC: IDA, PMID: 16882008); GO_0032496 (EC: IDA, PMID: 12406186); GO_0032769 (EC: IDA, PMID: 11943812); GO_0033138 (EC: ISS); GO_0034341 (EC: IDA, PMID: 19157893); GO_0034599 (EC: IEA); GO_0035067 (EC: IDA, PMID: 16959795); GO_0040012 (EC: IEA); GO_0042393 (EC: IDA, PMID: 16959795); GO_0042416 (EC: TAS); GO_0042493 (EC: IEA); GO_0042775 (EC: IEA); GO_0042802 (EC: IPI, PMID: 16330551); GO_0043014 (EC: IPI, PMID: 11698390); GO_0043027 (EC: IDA, PMID: 108…
has PubMed association: PMID: 7558013; 7568089; 7601450; 7601479; 7802671; 8248242; 8895469; 9163350; 9197268; 9462735; 9750188; 10092675; 10319874; 10407019; 10417297; 10464279; 10506125; 10617630; 10764738; 10818098; 10852916; 10973942; 11078745; 11156617; 11162638; 11173882; 11207390; 11227130; 11261505; 11279280; 11292651; 11312271; 11331421; 11357958; 11376188; 11425308; 11438481; 11447312; 11472875; 11487204; 11502187; 11532993; 11588587; 11603807; 11683992; 11687285; 11698390; 11701929; 11724769; 11742726; 11744621; 11748744; 11751692; 11790792; 11812148; 11812782; 11813001; 11814343; 11814405; 11821392; 11823645; 11850416; 11852183; 11889756; 11893734; 11900526; 11943812; 11956199; 12025860; 12042811; 12044636; 12059041; 12062445; 12070658; 12084935; 12096713; 12115139; 12121974; 12122208; 12124613; 12138709; 12145295; 12151787; 12217698; 12220378; 12239163; 12351642; 12352614; 12358748; 12367530; 12377775; 12406186; 12428717; 12428728; 12477932; 12493604; 12534279; 12534296; 12541013; 12551928; 12558071; 12576551; 12586824; 12598733; 12610000; 12661766; 12670421; 12672538; 12672549; 12684441; 12695511; 12714745; 12716427; 12716914; 12722828; 12727333; 12752402; 12783249; 12784265; 12807436; 12807439; 12815044; 12815663; 12819014; 12857790; 12859192; 12859200; 12867415; 12868067; 12868068; 12885775; 12893833; 12900507; 12923179; 12923682; 12928483; 12958153; 12963044; 12973692; 14506232; 14507911; 14550771; 14572463; 14583385; 14593171; 14596606; 14627698; 14645218; 14657499; 14657500; 14690528; 14692700; 14699135; 14711827; 14742448; 14755719; 14756560; 14987449; 14996933; 14997013; 15028717; 15033366; 15050722; 15064394; 15078109; 15096050; 15099020; 15103328; 15109581; 15132984; 15135042; 15155902; 15159488; 15180968; 15207266; 15234109; 15236975; 15247485; 15265037; 15280438; 15282274; 15289452; 15300629; 15304594; 15317865; 15333840; 15338643; 15364911; 15365127; 15451224; 15451225; 15455394; 15459341; 15465356; 15489334; 15496679; 15498564; 15502868; 15502874; 15522241; 15522…
description: synuclein, alpha (non A4 component of amyloid precursor)
database cross reference: Ensembl:ENSG00000145335
database cross reference: HGNC:11138
database cross reference: HPRD:01227
database cross reference: MIM:163890

SOD1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ALS
alternative term: ALS1
alternative term: HEL-S-44
alternative term: IPOA
alternative term: SOD
alternative term: hSod1
alternative term: homodimer
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SOD1
full name from nomenclature authority: superoxide dismutase 1, soluble
NCBI GeneID: 6647
gene map location: 21q22.11
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 21
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: ISS); GO_0000303 (EC: IDA, PMID: 16790527); GO_0001541 (EC: ISS); GO_0001819 (EC: IDA, PMID: 15544046); GO_0001890 (EC: NAS, PMID: 12485882); GO_0001895 (EC: ISS); GO_0001975 (EC: IEA); GO_0002262 (EC: ISS); GO_0002576 (EC: TAS); GO_0004784 (EC: EXP); GO_0004784 (EC: IDA, PMID: 12551919); GO_0004784 (EC: TAS); GO_0005507 (EC: IDA, PMID: 17008312); GO_0005515 (EC: IPI, PMID: 16369483); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 7172448); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005739 (EC: IDA, PMID: 16790527); GO_0005758 (EC: TAS); GO_0005759 (EC: NAS, PMID: 17008312); GO_0005777 (EC: IDA, PMID: 1332049); GO_0005777 (EC: ISS); GO_0005829 (EC: IDA, PMID: 16790527); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, Qualifier: colocalizes_with, PMID: 17077646); GO_0006302 (EC: ISS); GO_0006309 (EC: ISS); GO_0006749 (EC: ISS); GO_0006801 (EC: IDA, PMID: 12551919); GO_0006801 (EC: ISS); GO_0006879 (EC: ISS); GO_0007283 (EC: ISS); GO_0007566 (EC: ISS); GO_0007566 (EC: NAS, PMID: 10920331); GO_0007569 (EC: IMP, PMID: 12871978); GO_0007596 (EC: TAS); GO_0007605 (EC: ISS); GO_0007626 (EC: ISS); GO_0008089 (EC: ISS); GO_0008090 (EC: ISS); GO_0008217 (EC: ISS); GO_0008270 (EC: IDA, PMID: 17381088); GO_0009408 (EC: ISS); GO_0010033 (EC: IDA, PMID: 12921788); GO_0019226 (EC: ISS); GO_0019430 (EC: IBA); GO_0019430 (EC: ISS); GO_0030168 (EC: TAS); GO_0030346 (EC: IDA, PMID: 17324120); GO_0031012 (EC: IDA, PMID: 9699963); GO_0031410 (EC: IDA, PMID: 17077646); GO_0031667 (EC: IEA); GO_0032287 (EC: ISS); GO_0032314 (EC: IDA, PMID: 18219391); GO_0032839 (EC: IDA, PMID: 17324120); GO_0032930 (EC: IDA, PMID: 18219391); GO_0033081 (EC: NAS, PMID: 16716898); GO_0040014 (EC: ISS); GO_0042493 (EC: ISS); GO_0042542 (EC: ISS); GO_0042554 (EC: IEA); GO_0042802 (EC: IPI); GO_0042803 (EC: NAS, PMID: 10837872); GO_0043025 (EC: IDA, PMID: 17324120); GO_0043065 (EC: IC, PMID: 16790527); GO_0043085 (EC: IDA, PMID: 17324120); GO_0043234 (EC:…
has PubMed association: PMID: 752535; 1332049; 1463506; 2853161; 3160582; 3680284; 3889846; 6096825; 6316150; 6457647; 6577438; 6770891; 7002610; 7172448; 7496169; 7501156; 7643359; 7647793; 7655468; 7655469; 7655471; 7700376; 7755363; 7795609; 7836951; 7870076; 7881433; 7887412; 7911198; 7951249; 7951252; 7980516; 7997024; 8004110; 8069312; 8105280; 8179602; 8298637; 8332197; 8351519; 8446170; 8528216; 8592323; 8682505; 8900247; 8907321; 8909456; 8938700; 8990014; 9101297; 9131652; 9453566; 9455977; 9539776; 9541385; 9699963; 9718300; 9726962; 9817920; 10329151; 10400992; 10430435; 10439968; 10677207; 10732812; 10735277; 10809943; 10830953; 10837872; 10889018; 10920331; 11006081; 11115513; 11220750; 11350569; 11369193; 11457725; 11513882; 11527942; 11535232; 11561030; 11675874; 11756571; 11771762; 11854284; 11854285; 11912919; 11930144; 11951178; 11996514; 12039658; 12050154; 12099681; 12126755; 12127151; 12138710; 12144846; 12145308; 12210393; 12213295; 12215228; 12218958; 12270693; 12356748; 12393885; 12402272; 12437574; 12441104; 12442272; 12447480; 12458194; 12475980; 12477932; 12480087; 12485882; 12502789; 12531528; 12551919; 12573532; 12590575; 12597246; 12606529; 12626552; 12644909; 12649272; 12659845; 12661766; 12665801; 12686560; 12710511; 12710516; 12718436; 12729761; 12732844; 12738898; 12753090; 12754496; 12774661; 12783432; 12787913; 12815046; 12818209; 12871577; 12871978; 12921788; 12963085; 12963370; 12968035; 12972170; 13129803; 13129804; 14506936; 14526083; 14568129; 14578853; 14596848; 14630798; 14684739; 14690536; 14711010; 14718574; 14734542; 14759637; 14970233; 14975589; 14978393; 14981234; 14988262; 15006704; 15016076; 15050430; 15050437; 15068249; 15109247; 15123612; 15166009; 15193434; 15198682; 15223067; 15223614; 15233914; 15258228; 15263088; 15288122; 15295091; 15304256; 15326189; 15338334; 15350647; 15358145; 15377661; 15379995; 15456787; 15465081; 15473258; 15474511; 15475574; 15485869; 15488469; 15489334; 15507437; 15522970; 15531919; 15544046; 15546588; 1557…
description: superoxide dismutase 1, soluble
database cross reference: Ensembl:ENSG00000142168
database cross reference: HGNC:11179
database cross reference: HPRD:00937
database cross reference: MIM:147450
database cross reference: Vega:OTTHUMG00000084878

SORL1
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: C11orf32
alternative term: LR11
alternative term: LRP9
alternative term: SORLA
alternative term: SorLA-1
alternative term: gp250
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SORL1
full name from nomenclature authority: sortilin-related receptor, L(DLR class) A repeats containing
NCBI GeneID: 6653
gene map location: 11q23.2-q24.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004888 (EC: TAS, PMID: 9157966); GO_0005515 (EC: IPI, PMID: 14764453); GO_0005615 (EC: IDA, PMID: 14764453); GO_0005768 (EC: IDA, PMID: 16174740); GO_0005771 (EC: IEA); GO_0005794 (EC: IDA, PMID: 16174740); GO_0005887 (EC: TAS, PMID: 9157966); GO_0006605 (EC: IMP, PMID: 16174740); GO_0006869 (EC: IEA); GO_0006898 (EC: TAS, PMID: 9157966); GO_0007165 (EC: TAS, PMID: 9157966); GO_0008203 (EC: IEA); GO_0008219 (EC: IEA); GO_0008283 (EC: IEA); GO_0014910 (EC: IDA, PMID: 14764453); GO_0016020 (EC: IDA, PMID: 14764453); GO_0016477 (EC: IEA); GO_0030169 (EC: IPI, PMID: 17326667); GO_0034362 (EC: IEA); GO_0043025 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 8619474; 8940146; 9157966; 10375696; 11294867; 11557679; 11821067; 12477932; 12530537; 12970790; 14702039; 14764453; 15313836; 16174740; 16344560; 16407538; 16489755; 16531402; 16565469; 17110338; 17220890; 17326667; 17420311; 17589324; 17721864; 17826910; 17949987; 17975299; 17978276; 18063222; 18090307; 18093545; 18407551; 18541377; 18562096; 18603531; 18685254; 18713574; 18830724; 18938222; 19056867; 19064752; 19077115; 19364927; 19368828; 19539718; 19584446; 19653016; 19822782; 19889229; 19889475; 19913121; 20015111; 20047743; 20301340; 20379614; 20413850; 20534741; 20574532; 20625269; 20628086; 20634593; 20667857; 20689279; 20838585; 20880607; 20946940; 20970138; 21145461; 21147781; 21185108; 21206043; 21220680; 21385844; 21730226; 21989385; 21994944; 21997402; 22044026; 22127416; 22268729; 22279231; 22286501; 22297619; 22321011; 22472873; 22621900; 22750733; 22836009; 22927900; 22996644; 23127357; 23455993; 23463934; 23486467; 23525328; 23565137; 23602568; 23813966; 24001769
description: sortilin-related receptor, L(DLR class) A repeats containing
relation: Alzpathway: APP-SORL1 association. Source: https://pubmed.ncbi.nlm.nih.gov/16174740/
database cross reference: Ensembl:ENSG00000137642
database cross reference: HGNC:11185
database cross reference: HPRD:03595
database cross reference: MIM:602005
database cross reference: Vega:OTTHUMG00000166057

SOS2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SOS2
full name from nomenclature authority: son of sevenless homolog 2 (Drosophila)
NCBI GeneID: 6655
gene map location: 14q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 14
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003677 (EC: IEA); GO_0005089 (EC: IEA); GO_0005515 (EC: IPI, PMID: 14679214); GO_0005829 (EC: TAS); GO_0007264 (EC: TAS); GO_0007411 (EC: TAS); GO_0043065 (EC: TAS); GO_0046982 (EC: IEA); GO_0048011 (EC: TAS); GO_0051056 (EC: TAS); GO_0051057 (EC: IEA); GO_0097190 (EC: TAS)
has PubMed association: PMID: 7629138; 8276400; 8493579; 8943292; 9067577; 9182529; 9372945; 10675333; 10820259; 10938118; 10940929; 11003655; 11756498; 12097864; 12376548; 12477932; 12628188; 12787561; 14551139; 14679214; 15173068; 17143285; 17440948; 17474147; 18271526; 19289468; 19380743; 19531499; 19911011; 20467438; 20618341; 20697350; 20936779; 21706016; 21988832; 22558309; 23761422; 23956138; 24250222
description: son of sevenless homolog 2 (Drosophila)

UAP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AGX
alternative term: AGX1
alternative term: AGX2
alternative term: SPAG2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: UAP1
full name from nomenclature authority: UDP-N-acteylglucosamine pyrophosphorylase 1
NCBI GeneID: 6675
gene map location: 1q23.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003977 (EC: TAS); GO_0005829 (EC: TAS); GO_0006048 (EC: IEA); GO_0006048 (EC: TAS); GO_0006488 (EC: TAS); GO_0018279 (EC: TAS); GO_0030246 (EC: IEA); GO_0043687 (EC: TAS); GO_0044267 (EC: TAS)
has PubMed association: PMID: 8025165; 9603950; 9621304; 9765219; 11707391; 12477932; 15489334; 16710414; 16712791; 18029348; 18976975; 19322201; 19536175; 21139048; 21757351; 21890473; 21906983; 22939629; 23000965
description: UDP-N-acteylglucosamine pyrophosphorylase 1
database cross reference: Ensembl:ENSG00000117143
database cross reference: HGNC:12457
database cross reference: HPRD:04178
database cross reference: MIM:602862
database cross reference: Vega:OTTHUMG00000034419

SRC
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ASV
alternative term: SRC1
alternative term: c-SRC
alternative term: p60-Src
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SRC
full name from nomenclature authority: v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
NCBI GeneID: 6714
NCBI LocusTag: RP5-823N20.1
gene map location: 20q12-q13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004672 (EC: IDA, PMID: 18616680); GO_0004672 (EC: TAS); GO_0004713 (EC: EXP); GO_0004713 (EC: IDA, PMID: 16441665); GO_0004713 (EC: TAS); GO_0004715 (EC: TAS, PMID: 19267251); GO_0005070 (EC: TAS, PMID: 9020193); GO_0005102 (EC: IPI, PMID: 19332538); GO_0005178 (EC: TAS, PMID: 19267251); GO_0005515 (EC: IPI, PMID: 10521452); GO_0005524 (EC: IEA); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA); GO_0005739 (EC: IDA, PMID: 19767770); GO_0005743 (EC: IDA, PMID: 12615910); GO_0005764 (EC: IDA); GO_0005770 (EC: IDA); GO_0005829 (EC: IDA, PMID: 19767770); GO_0005829 (EC: TAS); GO_0005856 (EC: IEA); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0005901 (EC: IDA, PMID: 17848177); GO_0007049 (EC: IEA); GO_0007155 (EC: IEA); GO_0007165 (EC: TAS, PMID: 10734107); GO_0007172 (EC: TAS, PMID: 9924018); GO_0007173 (EC: TAS); GO_0007265 (EC: TAS); GO_0007411 (EC: TAS); GO_0007596 (EC: TAS); GO_0008543 (EC: TAS); GO_0016032 (EC: IEA); GO_0016301 (EC: TAS); GO_0018108 (EC: IDA); GO_0020037 (EC: IDA); GO_0030168 (EC: TAS); GO_0030900 (EC: IEA); GO_0031295 (EC: TAS); GO_0032463 (EC: IMP, PMID: 19767770); GO_0033146 (EC: IEA); GO_0033625 (EC: TAS, PMID: 19267251); GO_0035556 (EC: IDA, PMID: 15248232); GO_0038096 (EC: TAS); GO_0042169 (EC: IPI, PMID: 8070403); GO_0042802 (EC: IEA); GO_0043066 (EC: IMP, PMID: 19767770); GO_0043114 (EC: TAS, PMID: 19267251); GO_0043154 (EC: IMP, PMID: 19767770); GO_0043393 (EC: IEA); GO_0044325 (EC: IPI, PMID: 12538589); GO_0045087 (EC: TAS); GO_0045124 (EC: TAS, PMID: 19267251); GO_0045453 (EC: ISS); GO_0046777 (EC: IDA, PMID: 16441665); GO_0046875 (EC: IPI, PMID: 12925710); GO_0048011 (EC: TAS); GO_0048477 (EC: IEA); GO_0050847 (EC: ISS); GO_0050900 (EC: TAS); GO_0051219 (EC: IPI, PMID: 16441665); GO_0051895 (EC: ISS); GO_0051897 (EC: IMP, PMID: 19767770); GO_0051902 (EC: IMP, PMID: 19767770); GO_0060065 (EC: IEA); GO_0060444 (EC: IEA); GO_0061024 (EC: TAS); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070374 (EC: IEA); GO_0070555 (EC: IMP, PMID: 19281832);…
has PubMed association: PMID: 1310678; 1374686; 1379745; 1383690; 1384654; 1545818; 1689310; 1691439; 1713455; 1717825; 2173144; 2457390; 2506951; 2581127; 2582238; 2681803; 2981336; 2996754; 2996780; 3299057; 3917576; 6092965; 6304688; 6333425; 7510703; 7513017; 7513429; 7515480; 7516469; 7517401; 7518772; 7519780; 7521304; 7527558; 7529876; 7530249; 7532003; 7534286; 7537265; 7537362; 7537495; 7539106; 7542762; 7678701; 7681396; 7682059; 7683128; 7691597; 7782294; 7997267; 8054685; 8070403; 8253717; 8272872; 8510939; 8621384; 8626374; 8632005; 8635998; 8647432; 8647855; 8657103; 8657134; 8681387; 8702721; 8761480; 8766817; 8797825; 8805332; 8810341; 8816475; 8824280; 8845374; 8849729; 8876196; 8878483; 8885868; 8900189; 8910575; 8918464; 8939605; 8940173; 8941336; 8953041; 8978822; 9012831; 9016807; 9020193; 9024657; 9028946; 9096689; 9118959; 9148935; 9169421; 9174343; 9178760; 9182531; 9195899; 9208935; 9223281; 9237663; 9261115; 9278444; 9297626; 9344858; 9388490; 9389695; 9507031; 9519902; 9560226; 9566874; 9584165; 9600099; 9621077; 9632142; 9655255; 9687503; 9687533; 9701558; 9710204; 9748248; 9763511; 9778343; 9786846; 9792645; 9819391; 9819392; 9822703; 9837922; 9837958; 9843378; 9867848; 9880482; 9924018; 9988270; 10022920; 10070972; 10075741; 10085298; 10092678; 10187839; 10195142; 10205168; 10206955; 10339567; 10358079; 10362724; 10391903; 10395945; 10428862; 10454579; 10455176; 10455194; 10458595; 10462375; 10467411; 10482988; 10487518; 10517671; 10521452; 10527887; 10544291; 10567404; 10571082; 10635328; 10636929; 10644995; 10657632; 10681522; 10688651; 10698938; 10734107; 10739664; 10744074; 10777539; 10777553; 10781592; 10787408; 10801826; 10829062; 10838070; 10846184; 10847592; 10858437; 10871840; 10884433; 10899172; 10918587; 10931187; 10935545; 10945997; 10959835; 10962563; 10971656; 10973497; 10978326; 10982829; 11007774; 11013076; 11013230; 11024032; 11031247; 11032808; 11039464; 11071635; 11078745; 11084024; 11085988; 11106497; 11113628; 11124251; 11127814; 11149959;…
description: v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
database cross reference: Ensembl:ENSG00000197122
database cross reference: HGNC:11283
database cross reference: HPRD:01819
database cross reference: MIM:190090
database cross reference: Vega:OTTHUMG00000032417

SRI
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CP-22
alternative term: CP22
alternative term: SCN
alternative term: V19
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SRI
full name from nomenclature authority: sorcin
NCBI GeneID: 6717
gene map location: 7q21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001508 (EC: TAS, PMID: 9668070); GO_0002020 (EC: IPI, PMID: 10748169); GO_0004198 (EC: IBA); GO_0005102 (EC: TAS, PMID: 9668070); GO_0005246 (EC: TAS, PMID: 9668070); GO_0005509 (EC: IDA, PMID: 17215369); GO_0005515 (EC: IPI); GO_0005737 (EC: TAS, PMID: 16130169); GO_0005789 (EC: IDA, PMID: 10672515); GO_0005829 (EC: IDA, PMID: 10748169); GO_0006508 (EC: IBA); GO_0006810 (EC: TAS, PMID: 9668070); GO_0006816 (EC: IEA); GO_0006880 (EC: TAS, PMID: 9668070); GO_0006942 (EC: TAS, PMID: 9668070); GO_0007165 (EC: TAS, PMID: 16130169); GO_0007507 (EC: TAS, PMID: 9668070); GO_0007517 (EC: TAS, PMID: 9668070); GO_0008016 (EC: TAS, PMID: 9668070); GO_0010459 (EC: IMP, PMID: 12754254); GO_0010649 (EC: TAS, PMID: 17699613); GO_0010880 (EC: TAS, PMID: 17699613); GO_0016020 (EC: IDA, PMID: 10748169); GO_0016529 (EC: TAS, PMID: 17699613); GO_0030018 (EC: IDA, PMID: 12754254); GO_0030315 (EC: TAS, PMID: 17699613); GO_0033017 (EC: IEA); GO_0035774 (EC: IEA); GO_0042584 (EC: IDA, Qualifier: colocalizes_with, PMID: 9268363); GO_0042994 (EC: IEA); GO_0044325 (EC: TAS, PMID: 12754254); GO_0046982 (EC: IPI, PMID: 12804766); GO_0051281 (EC: IEA); GO_0051924 (EC: IMP, PMID: 12754254); GO_0060315 (EC: IDA, PMID: 17699613); GO_0070062 (EC: IDA, PMID: 15326289); GO_0070491 (EC: IEA); GO_0086004 (EC: IMP, PMID: 12754254); GO_1901077 (EC: IMP, PMID: 12754254); GO_1901841 (EC: IMP, PMID: 12754254); GO_1901844 (EC: IMP, PMID: 17130302); GO_2000678 (EC: IEA)
has PubMed association: PMID: 1286667; 2901906; 7592856; 7835417; 7873602; 8561500; 9268363; 9570944; 9668070; 10672515; 10748169; 11714909; 12408767; 12411058; 12477932; 12754254; 12804766; 15231748; 15326289; 15489334; 15808837; 15862967; 16130169; 16169070; 16189514; 16320026; 16341674; 16344560; 16931553; 16934756; 17130302; 17215369; 17541155; 17643375; 17699613; 17893145; 18315902; 18423116; 18624398; 19738201; 19885748; 19913121; 20012234; 20628086; 20647321; 20858460; 20972266; 21109982; 21139048; 21890473; 21906983; 21963094; 21979464; 21988832; 22052463; 22053931; 22338092; 22623428; 22701893; 23000965; 23602568
description: sorcin
database cross reference: Ensembl:ENSG00000075142
database cross reference: HGNC:11292
database cross reference: HPRD:01680
database cross reference: MIM:182520
database cross reference: Vega:OTTHUMG00000157267

SST
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SMST
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SST
full name from nomenclature authority: somatostatin
NCBI GeneID: 6750
gene map location: 3q28
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005179 (EC: TAS, PMID: 9886848); GO_0005576 (EC: TAS); GO_0005615 (EC: TAS, PMID: 9437026); GO_0006972 (EC: IEA); GO_0007166 (EC: TAS, PMID: 9437026); GO_0007186 (EC: TAS, PMID: 8405411); GO_0007267 (EC: TAS, PMID: 6145156); GO_0007268 (EC: TAS, PMID: 9437026); GO_0007584 (EC: TAS, PMID: 6145156); GO_0007586 (EC: TAS, PMID: 6145156); GO_0008285 (EC: TAS, PMID: 9886848); GO_0008628 (EC: TAS, PMID: 8961277); GO_0009408 (EC: IEA); GO_0030334 (EC: IEA); GO_0042493 (EC: IEA); GO_0043025 (EC: IEA); GO_0043200 (EC: IEA); GO_0048545 (EC: IEA)
has PubMed association: PMID: 1337145; 1346068; 4682131; 6126875; 6142531; 6145156; 6196780; 7908405; 8100352; 8405411; 8612489; 8961277; 9437026; 9878821; 9886848; 11753230; 11814357; 11823046; 11860030; 11920268; 12174892; 12477932; 12684217; 12902325; 12952361; 14559725; 15266779; 15286801; 15358539; 15472172; 15489334; 15590633; 15655830; 16043736; 16211223; 16214911; 16284732; 16456666; 16606630; 16736556; 16764985; 16804989; 16952549; 17130427; 17229384; 17327350; 17704349; 17987251; 18196269; 18240029; 18310290; 18473402; 18567806; 18577758; 18617261; 18753129; 19086053; 19106227; 19328558; 19423539; 19559700; 19607727; 19733630; 20043075; 20055772; 20501436; 20602615; 20629740; 20634197; 20734064; 20800603; 20810604; 20819778; 21232602; 21368047; 21632809; 21640760; 22366760; 22509294; 22528496; 22532184; 22932785; 23128854; 23312523; 23825418
description: somatostatin
database cross reference: Ensembl:ENSG00000157005
database cross reference: HGNC:11329
database cross reference: HPRD:08920
database cross reference: MIM:182450
database cross reference: Vega:OTTHUMG00000156462

STK11
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LKB1
alternative term: PJS
alternative term: hLKB1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: STK11
full name from nomenclature authority: serine/threonine kinase 11
NCBI GeneID: 6794
gene map location: 19p13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000287 (EC: IDA, PMID: 12805220); GO_0001558 (EC: ISS); GO_0001894 (EC: IEA); GO_0001944 (EC: ISS); GO_0002039 (EC: IDA, PMID: 11430832); GO_0004674 (EC: IDA, PMID: 11430832); GO_0004674 (EC: TAS); GO_0005515 (EC: IPI, PMID: 12595760); GO_0005524 (EC: IDA, PMID: 12805220); GO_0005634 (EC: IDA); GO_0005737 (EC: IDA, PMID: 11430832); GO_0005739 (EC: IDA, PMID: 11430832); GO_0005829 (EC: ISS); GO_0005829 (EC: TAS); GO_0006112 (EC: TAS); GO_0006468 (EC: IDA, PMID: 12805220); GO_0006914 (EC: IEA); GO_0006974 (EC: IEA); GO_0007050 (EC: IDA, PMID: 12805220); GO_0007050 (EC: TAS); GO_0007286 (EC: IEA); GO_0007409 (EC: IEA); GO_0008285 (EC: IMP, PMID: 17216128); GO_0008286 (EC: TAS); GO_0010212 (EC: ISS); GO_0016020 (EC: ISS); GO_0030010 (EC: ISS); GO_0030111 (EC: IEA); GO_0030275 (EC: IEA); GO_0030295 (EC: IDA, PMID: 19892943); GO_0030308 (EC: ISS); GO_0030511 (EC: IMP, PMID: 18311138); GO_0032147 (EC: IDA, PMID: 18854309); GO_0032147 (EC: IEA); GO_0032403 (EC: IEA); GO_0033762 (EC: IEA); GO_0033993 (EC: IEA); GO_0036398 (EC: IEA); GO_0036399 (EC: IEA); GO_0042304 (EC: TAS); GO_0042593 (EC: ISS); GO_0043276 (EC: IMP, PMID: 19622832); GO_0044281 (EC: TAS); GO_0045059 (EC: IEA); GO_0045722 (EC: IEA); GO_0046777 (EC: IDA, PMID: 11430832); GO_0050731 (EC: IEA); GO_0050772 (EC: IEA); GO_0050852 (EC: IEA); GO_0051291 (EC: IEA); GO_0051645 (EC: IEA); GO_0051896 (EC: IEA); GO_0060070 (EC: IEA); GO_0060770 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0072332 (EC: IDA, PMID: 11430832)
has PubMed association: PMID: 8889548; 8988175; 9425897; 9428765; 9537235; 9760200; 9837816; 10208439; 10362809; 10408777; 10508479; 10642499; 10642527; 11297520; 11430832; 11445556; 11668633; 11733352; 11741830; 11853558; 12097271; 12218179; 12234250; 12477932; 12489981; 12533684; 12552571; 12595760; 12753905; 12805220; 12847291; 12879020; 12912948; 14511394; 14511408; 14517247; 14517248; 14668798; 14676191; 14702039; 14976552; 14985505; 15077168; 15121768; 15183188; 15188174; 15231735; 15287029; 15292028; 15331174; 15485651; 15489334; 15561763; 15607222; 15608654; 15617552; 15731909; 15733851; 15774015; 15800014; 15987703; 16054041; 16169070; 16287113; 16311241; 16396636; 16407220; 16407837; 16540748; 16580634; 16582077; 16648371; 16822578; 16882735; 16912160; 16927138; 16953221; 17010524; 17026623; 17098823; 17108107; 17114342; 17212587; 17216128; 17234589; 17244606; 17319781; 17344591; 17384680; 17573348; 17575127; 17599048; 17637250; 17641416; 17676035; 17711506; 17766436; 17884763; 17921699; 17928927; 17950019; 18000088; 18029348; 18199157; 18245474; 18256292; 18303014; 18311138; 18321849; 18403917; 18483235; 18495044; 18594528; 18600394; 18676680; 18681789; 18687677; 18794113; 18854309; 18854318; 19029933; 19056867; 19068194; 19145097; 19165201; 19170196; 19177591; 19204826; 19229701; 19250387; 19287990; 19340305; 19351817; 19369417; 19386264; 19407487; 19414597; 19463221; 19507030; 19513107; 19520843; 19584313; 19615099; 19615732; 19622832; 19625176; 19692168; 19724060; 19727776; 19892943; 19908348; 20010869; 20018878; 20020146; 20057966; 20082862; 20193846; 20207041; 20227367; 20301443; 20354225; 20357370; 20368287; 20368693; 20400510; 20418665; 20423848; 20424326; 20428811; 20435009; 20452353; 20489196; 20497868; 20559149; 20562859; 20623358; 20668229; 20682687; 20686846; 20722467; 20818976; 20864035; 20881644; 20939895; 20956321; 20974850; 21048031; 21102257; 21118512; 21150337; 21191146; 21191700; 21192934; 21241696; 21396365; 21450399; 21532627; 21572398; 21706049; 21816872; 2…
description: serine/threonine kinase 11
database cross reference: Ensembl:ENSG00000118046
database cross reference: HGNC:11389
database cross reference: HPRD:03740
database cross reference: MIM:602216
database cross reference: Vega:OTTHUMG00000180118

STXBP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MUNC18-1
alternative term: NSEC1
alternative term: P67
alternative term: RBSEC1
alternative term: UNC18
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: STXBP1
full name from nomenclature authority: syntaxin binding protein 1
NCBI GeneID: 6812
NCBI LocusTag: RP11-56D16.3
gene map location: 9q34.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000149 (EC: ISS); GO_0002576 (EC: IMP, PMID: 12773094); GO_0005737 (EC: ISS); GO_0005739 (EC: ISS); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 12773094); GO_0005886 (EC: ISS, Qualifier: colocalizes_with); GO_0006112 (EC: TAS); GO_0006904 (EC: IEA); GO_0007268 (EC: TAS); GO_0007269 (EC: TAS); GO_0007274 (EC: IEA); GO_0007412 (EC: ISS); GO_0010807 (EC: ISS); GO_0014047 (EC: TAS); GO_0015031 (EC: IEA); GO_0016188 (EC: ISS); GO_0017075 (EC: ISS); GO_0019901 (EC: IEA); GO_0019904 (EC: IEA); GO_0019905 (EC: IPI, PMID: 12773094); GO_0031091 (EC: IDA, PMID: 12773094); GO_0032229 (EC: ISS); GO_0042802 (EC: ISS); GO_0043234 (EC: ISS); GO_0043524 (EC: IEA); GO_0044281 (EC: TAS); GO_0044822 (EC: IDA); GO_0045956 (EC: IEA); GO_0047485 (EC: IEA); GO_0050796 (EC: TAS); GO_0050821 (EC: IEA); GO_0060292 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070527 (EC: IMP, PMID: 12773094)
has PubMed association: PMID: 7553862; 7698978; 7768895; 8108429; 8631738; 8824310; 9045631; 9115738; 9395480; 9545644; 9933594; 10194441; 10449403; 10746715; 10903204; 11927603; 12016213; 12093152; 12477932; 12519779; 12590134; 12773094; 12950453; 12963086; 14702039; 14702098; 14744865; 15175344; 15489225; 15489334; 15563604; 15592455; 15635413; 16413130; 16722236; 17200691; 17264080; 17363971; 17500595; 18268500; 18469812; 18617632; 18781797; 18854154; 19019082; 19056867; 19557857; 19686046; 20471030; 20681955; 20876469; 20887364; 21139048; 21204804; 21364700; 21565611; 21669024; 21762454; 21770924; 21832049; 21906983; 22211739; 22360420; 22939629; 23091057; 23409955; 23487749; 23858467
description: syntaxin binding protein 1
database cross reference: Ensembl:ENSG00000136854
database cross reference: HGNC:11444
database cross reference: HPRD:04235
database cross reference: MIM:602926
database cross reference: Vega:OTTHUMG00000020713

SUOX
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SUOX
full name from nomenclature authority: sulfite oxidase
NCBI GeneID: 6821
gene map location: 12q13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000096 (EC: TAS); GO_0000098 (EC: TAS); GO_0005758 (EC: IEA); GO_0005759 (EC: TAS); GO_0008482 (EC: TAS); GO_0009055 (EC: IEA); GO_0020037 (EC: IEA); GO_0030151 (EC: IEA); GO_0034641 (EC: TAS); GO_0043546 (EC: IEA); GO_0044281 (EC: TAS); GO_0070221 (EC: TAS)
has PubMed association: PMID: 7599189; 9428520; 9600976; 10519592; 12112661; 12368985; 12424234; 12477932; 12763039; 12832761; 14567685; 14729666; 15489334; 16140720; 16229463; 16344560; 16475804; 17366837; 17940249; 18177044; 18198356; 18529001; 18959753; 19850743; 20063894; 20491442; 20877624; 21988832; 22263579; 22885925; 22951725; 22975842
description: sulfite oxidase

VAMP2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SYB2
alternative term: VAMP-2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: VAMP2
full name from nomenclature authority: vesicle-associated membrane protein 2 (synaptobrevin 2)
NCBI GeneID: 6844
gene map location: 17p13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005484 (EC: IBA); GO_0005515 (EC: IPI, PMID: 17196367); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 1976629); GO_0006112 (EC: TAS); GO_0006892 (EC: TAS); GO_0006906 (EC: IBA); GO_0007268 (EC: TAS); GO_0007269 (EC: TAS); GO_0008021 (EC: IBA); GO_0014047 (EC: TAS); GO_0016020 (EC: IDA); GO_0017156 (EC: IEA); GO_0017157 (EC: IBA); GO_0019905 (EC: IBA); GO_0030054 (EC: IEA); GO_0030136 (EC: IDA, PMID: 19478182); GO_0030666 (EC: TAS); GO_0030667 (EC: TAS); GO_0030672 (EC: IEA); GO_0031201 (EC: IDA, PMID: 19546860); GO_0043005 (EC: IEA); GO_0044267 (EC: TAS); GO_0044281 (EC: TAS); GO_0050796 (EC: TAS); GO_0060203 (EC: TAS); GO_0061024 (EC: TAS); GO_0061202 (EC: TAS); GO_0070083 (EC: TAS)
has PubMed association: PMID: 1976629; 7499863; 7553862; 7622514; 7835332; 7961655; 8011337; 8071310; 8125298; 8760387; 8770861; 8973549; 8999968; 9030619; 9341137; 9396746; 9657962; 9658161; 9817754; 9920726; 10036234; 10100611; 10194441; 10336434; 10370136; 10449403; 10662545; 10713150; 10820264; 10965122; 11031247; 11101518; 11252894; 11278762; 11295657; 11524423; 11786915; 11832227; 11842301; 11994746; 12093152; 12130530; 12181340; 12200427; 12417022; 12477932; 12485399; 12517971; 12750892; 12773094; 12828989; 12832401; 12847087; 12853575; 14702039; 15327778; 15610015; 16195891; 17001002; 17196367; 17207965; 17255364; 17313651; 17331077; 17356306; 18182011; 18511417; 18511418; 18512733; 18628682; 19478182; 19546860; 19557857; 19822142; 20416077; 20471030; 20676083; 21139048; 21565611; 21808019; 21890473; 21906983; 21963094; 21987572; 22053931; 22172278; 22505724; 22645275; 22890573; 22939629; 23000965; 24250222
description: vesicle-associated membrane protein 2 (synaptobrevin 2)
database cross reference: Ensembl:ENSG00000220205
database cross reference: HGNC:12643
database cross reference: HPRD:01717
database cross reference: MIM:185881
database cross reference: Vega:OTTHUMG00000150254

SYP
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MRX96
alternative term: MRXSYP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SYP
full name from nomenclature authority: synaptophysin
NCBI GeneID: 6855
gene map location: Xp11.23-p11.22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005215 (EC: IEA); GO_0006897 (EC: ISS); GO_0015485 (EC: IDA, PMID: 10620806); GO_0016188 (EC: NAS, PMID: 10620806); GO_0017075 (EC: IEA); GO_0030054 (EC: IEA); GO_0030285 (EC: NAS, PMID: 1975480); GO_0032403 (EC: IEA); GO_0042169 (EC: IEA); GO_0042734 (EC: IEA); GO_0042802 (EC: IEA); GO_0043234 (EC: IEA); GO_0044306 (EC: IEA); GO_0048168 (EC: IBA); GO_0048169 (EC: ISS); GO_0048172 (EC: ISS); GO_0048499 (EC: NAS, PMID: 10620806); GO_0048786 (EC: IEA); GO_0060076 (EC: IEA); GO_0071310 (EC: IEA); GO_2000474 (EC: ISS)
has PubMed association: PMID: 1908157; 1975480; 2163183; 3120152; 7534299; 7553862; 8547634; 8772779; 9112016; 9344658; 9889259; 9930883; 10541003; 10595912; 10620806; 11426054; 11472886; 11508360; 11786535; 12077483; 12097487; 12107411; 12137757; 12181340; 12403815; 12477932; 12485399; 12492469; 12493563; 12498786; 12575533; 12701886; 12826904; 14702039; 15489334; 15694236; 16082702; 16721760; 16807900; 16894395; 17005904; 17207965; 17331077; 17500595; 17724707; 17916412; 18006193; 18662323; 18771509; 19377476; 19652998; 19724850; 20847448; 21073671; 22055401; 22099865; 22210727; 22348818; 22449227; 22843923; 23022470; 23242284; 23292839; 23418554; 23763443; 24250222
description: synaptophysin
database cross reference: Ensembl:ENSG00000102003
database cross reference: HGNC:11506
database cross reference: HPRD:02435
database cross reference: MIM:313475
database cross reference: Vega:OTTHUMG00000034557

ADAM17
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ADAM18
alternative term: CD156B
alternative term: CSVP
alternative term: NISBD
alternative term: TACE
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ADAM17
full name from nomenclature authority: ADAM metallopeptidase domain 17
NCBI GeneID: 6868
gene map location: 2p25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001666 (EC: IDA, PMID: 18276953); GO_0001934 (EC: IMP, PMID: 18625725); GO_0002446 (EC: IC, PMID: 16034137); GO_0002467 (EC: ISS, PMID: 10433800); GO_0002690 (EC: IC, PMID: 16034137); GO_0004222 (EC: IDA); GO_0004222 (EC: IMP, PMID: 9034190); GO_0004222 (EC: TAS); GO_0005112 (EC: IDA); GO_0005138 (EC: IPI, PMID: 16034137); GO_0005178 (EC: IPI, PMID: 14970227); GO_0005515 (EC: IPI, PMID: 10527948); GO_0005737 (EC: IDA); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 17786981); GO_0005911 (EC: IDA, Qualifier: colocalizes_with, PMID: 14970227); GO_0005925 (EC: IDA, Qualifier: colocalizes_with, PMID: 14970227); GO_0006509 (EC: IDA, PMID: 17786981); GO_0006509 (EC: IMP, PMID: 12743035); GO_0006915 (EC: TAS); GO_0007155 (EC: IDA, PMID: 14970227); GO_0007173 (EC: IDA, PMID: 12743035); GO_0007173 (EC: TAS); GO_0007219 (EC: IEA); GO_0007220 (EC: IDA); GO_0008237 (EC: IDA, PMID: 12777399); GO_0008237 (EC: IMP, PMID: 12535668); GO_0008237 (EC: TAS); GO_0008270 (EC: IEA); GO_0008284 (EC: IMP, PMID: 18373975); GO_0009986 (EC: IDA, PMID: 18383040); GO_0010820 (EC: IMP, PMID: 18373975); GO_0015629 (EC: IDA, PMID: 17010968); GO_0016324 (EC: IDA, PMID: 16034137); GO_0017124 (EC: IEA); GO_0022617 (EC: TAS); GO_0030165 (EC: IPI, PMID: 12207026); GO_0030183 (EC: ISS, PMID: 10433800); GO_0030198 (EC: TAS); GO_0030307 (EC: IMP, PMID: 18373975); GO_0030335 (EC: IMP, PMID: 18373975); GO_0030511 (EC: ISS, PMID: 10433800); GO_0030574 (EC: TAS); GO_0031293 (EC: TAS); GO_0031659 (EC: IDA, PMID: 18483258); GO_0032496 (EC: IDA, PMID: 18383040); GO_0032587 (EC: IDA, Qualifier: colocalizes_with, PMID: 14970227); GO_0032717 (EC: IMP, PMID: 16034137); GO_0032722 (EC: IMP, PMID: 16034137); GO_0033025 (EC: ISS, PMID: 10433800); GO_0033077 (EC: ISS, PMID: 10433800); GO_0033627 (EC: IDA, PMID: 14970227); GO_0035313 (EC: IEP, PMID: 14970227); GO_0035625 (EC: IMP, PMID: 17655843); GO_0042493 (EC: ISS, PMID: 10433800); GO_0045121 (EC: IDA, PMID: 17010968); GO_0045741 (EC: IDA, PMID: 18483258); GO_004…
has PubMed association: PMID: 8889548; 9034190; 9034191; 9520379; 9574564; 9620803; 9774383; 9806848; 9920899; 10224132; 10433800; 10527948; 10799478; 10860581; 10882063; 11733179; 11741929; 11823465; 11988096; 12044879; 12058067; 12135369; 12147693; 12207026; 12441351; 12474981; 12477932; 12535668; 12568494; 12606576; 12621058; 12668732; 12706122; 12711607; 12714588; 12730960; 12743035; 12755693; 12777399; 12810728; 12832423; 12947092; 12972643; 14532978; 14625290; 14970227; 15066987; 15102849; 15146197; 15182369; 15280379; 15308656; 15309730; 15337756; 15534001; 15691827; 15784625; 15983030; 16034137; 16079149; 16148149; 16179345; 16210695; 16246259; 16279945; 16332693; 16336275; 16376986; 16478662; 16619241; 16641105; 16806063; 16900751; 16912185; 16942750; 16982746; 17010968; 17081983; 17155946; 17170699; 17227756; 17360351; 17405915; 17438092; 17608729; 17655843; 17714581; 17786981; 17942404; 17986144; 17999917; 18029348; 18167350; 18171982; 18238782; 18276953; 18281553; 18355445; 18373975; 18383040; 18396294; 18426733; 18442814; 18483258; 18490652; 18493210; 18600307; 18625725; 18636124; 18638486; 18676862; 18713734; 18818406; 18824549; 18922903; 18978678; 18979631; 19003995; 19082505; 19091752; 19124506; 19150341; 19154693; 19171023; 19253070; 19278423; 19296470; 19298600; 19299578; 19324423; 19376560; 19435795; 19482949; 19515085; 19535569; 19541935; 19564338; 19595713; 19633828; 19666115; 19704010; 19762488; 19772640; 19819120; 19843672; 19875451; 19913121; 19949420; 19959661; 20026129; 20059578; 20070837; 20118276; 20180536; 20184396; 20188673; 20221248; 20300049; 20300969; 20359533; 20379614; 20506406; 20551051; 20627730; 20628086; 20634891; 20679348; 20807704; 20811902; 20819075; 20863729; 20871631; 20922190; 21102583; 21153921; 21170088; 21175594; 21240579; 21268712; 21300824; 21359495; 21365281; 21386996; 21407195; 21423656; 21480393; 21501859; 21777519; 21837402; 21865167; 21890473; 21906983; 21925169; 21932060; 21949123; 22010916; 22018416; 22105359; 22139867; 22157716; 222…
description: ADAM metallopeptidase domain 17
database cross reference: Ensembl:ENSG00000151694
database cross reference: HGNC:195
database cross reference: HPRD:04703
database cross reference: MIM:603639
database cross reference: Vega:OTTHUMG00000090425

TF
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PRO1557
alternative term: PRO2086
alternative term: TFQTL1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TF
full name from nomenclature authority: transferrin
NCBI GeneID: 7018
NCBI LocusTag: PRO1400
gene map location: 3q22.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001895 (EC: IEP); GO_0002576 (EC: TAS); GO_0005515 (EC: IPI, PMID: 15880641); GO_0005576 (EC: NAS, PMID: 14718574); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA); GO_0005769 (EC: IDA, PMID: 15880641); GO_0005770 (EC: IDA, PMID: 15880641); GO_0005905 (EC: IDA, PMID: 12857860); GO_0006879 (EC: TAS); GO_0007596 (EC: TAS); GO_0008199 (EC: IEA); GO_0009925 (EC: IDA, PMID: 15880641); GO_0009986 (EC: IDA, PMID: 16195351); GO_0010008 (EC: TAS); GO_0016023 (EC: IDA, PMID: 12857860); GO_0016324 (EC: IDA, PMID: 11208127); GO_0030139 (EC: IDA, PMID: 15229288); GO_0030168 (EC: TAS); GO_0031625 (EC: IEA); GO_0033572 (EC: TAS); GO_0034774 (EC: TAS); GO_0045178 (EC: IDA, PMID: 15880641); GO_0048471 (EC: IDA, PMID: 15880641); GO_0055037 (EC: IDA, PMID: 15880641); GO_0055085 (EC: TAS); GO_0070062 (EC: IDA, PMID: 19056867); GO_0072562 (EC: IDA)
has PubMed association: PMID: 1602151; 1809186; 1851757; 1932003; 2780570; 2874839; 3057819; 3106157; 3436225; 3678832; 3786138; 3858812; 5610700; 5711079; 5927288; 6268632; 6322780; 6457647; 6585826; 6690479; 6833213; 6953407; 7498159; 8125298; 8499451; 8889548; 9272172; 9312001; 9358047; 9570576; 9609685; 9760232; 9803271; 10029548; 10931525; 11027676; 11110675; 11208127; 11297622; 11436564; 11445282; 11606717; 11702220; 11703331; 11725818; 11749962; 11785295; 11800564; 11903051; 11920219; 11940510; 12044175; 12111369; 12135367; 12145410; 12165535; 12175089; 12207902; 12210842; 12223217; 12450380; 12458193; 12459033; 12473103; 12477932; 12522210; 12617162; 12626412; 12819023; 12857860; 12884526; 12939601; 12942785; 12951205; 14523999; 14567694; 14580189; 14614458; 14630798; 14643898; 14645044; 14702039; 14718574; 14757931; 14760718; 14980223; 15042587; 15060098; 15084671; 15111541; 15214509; 15214510; 15229288; 15252009; 15271890; 15292400; 15319290; 15327995; 15466165; 15489334; 15525538; 15536627; 15634274; 15648851; 15698609; 15880641; 15892129; 15924420; 15975770; 16047113; 16085060; 16169070; 16195351; 16199891; 16288727; 16300393; 16331960; 16335952; 16339299; 16354665; 16354686; 16373913; 16497717; 16538641; 16564538; 16740002; 17008590; 17011669; 17047092; 17116317; 17119318; 17192785; 17206377; 17496814; 17573378; 17601350; 17640392; 17711300; 17728504; 17976429; 17980706; 18022819; 18029348; 18045615; 18067952; 18097132; 18245657; 18257091; 18307987; 18344013; 18395717; 18442477; 18509548; 18597674; 18624398; 18654083; 18795173; 18813964; 18830724; 18835036; 18977241; 19021568; 19056867; 19084217; 19110265; 19165391; 19176989; 19219998; 19228837; 19250966; 19254567; 19281173; 19290554; 19515372; 19545871; 19572083; 19583819; 19650928; 19670106; 19693784; 19698254; 19761807; 19828835; 19838776; 19852572; 19856410; 19859668; 19913121; 19916167; 19917294; 19921860; 20029940; 20052609; 20064616; 20066543; 20096706; 20113254; 20118108; 20150920; 20164577; 20188707; 20215856; 2030958…
description: transferrin
database cross reference: Ensembl:ENSG00000091513
database cross reference: HGNC:11740
database cross reference: HPRD:01811
database cross reference: MIM:190000
database cross reference: Vega:OTTHUMG00000150356

TFAM
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MTTF1
alternative term: MTTFA
alternative term: TCF6
alternative term: TCF6L1
alternative term: TCF6L2
alternative term: TCF6L3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TFAM
full name from nomenclature authority: transcription factor A, mitochondrial
NCBI GeneID: 7019
gene map location: 10q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003682 (EC: IDA, PMID: 18063578); GO_0003700 (EC: IMP); GO_0005515 (EC: IPI, PMID: 12897151); GO_0005739 (EC: IDA); GO_0005759 (EC: TAS); GO_0006261 (EC: TAS, PMID: 8333869); GO_0006356 (EC: TAS, PMID: 8333869); GO_0006390 (EC: IMP); GO_0006390 (EC: TAS); GO_0006391 (EC: IDA); GO_0006391 (EC: TAS); GO_0008301 (EC: IDA); GO_0010467 (EC: TAS); GO_0031072 (EC: IEA); GO_0033108 (EC: IEA); GO_0042645 (EC: IDA, PMID: 18063578); GO_0044822 (EC: IDA); GO_0045893 (EC: IDA); GO_0070363 (EC: IDA, PMID: 19304746)
has PubMed association: PMID: 1610904; 1737790; 2035027; 2628167; 3211148; 3594571; 7599198; 7789991; 7849699; 7969115; 8061564; 8108407; 8166737; 8333869; 8441424; 8889548; 9063738; 9181464; 9309692; 9679658; 11457459; 11668394; 11964388; 11972329; 12068295; 12095695; 12127986; 12428064; 12477932; 12626705; 12686611; 12839966; 12897151; 12921794; 14969715; 15126285; 15464268; 15489334; 15509786; 15525513; 15526033; 15547250; 15965051; 16043643; 16202542; 16385451; 16428295; 16631115; 17167045; 17192785; 17339235; 17497594; 17537576; 17707600; 18028422; 18029348; 18063578; 18072287; 18248889; 18258228; 18430995; 18451773; 18642640; 18660489; 18716221; 18830724; 18980857; 19096125; 19148128; 19192634; 19209188; 19304746; 19322201; 19496804; 19624753; 19653005; 19681768; 19738201; 19885567; 19925850; 20186120; 20202876; 20410300; 20413850; 20432700; 20534741; 20562347; 20574532; 20643228; 20739229; 20843780; 20863902; 20877624; 20880607; 20972266; 20977898; 21081181; 21139048; 21145461; 21150319; 21453679; 21467167; 21514422; 21799244; 21890473; 21948790; 22037171; 22037172; 22098591; 22129993; 22266811; 22306509; 22354563; 22493245; 22675199; 22709542; 22841477; 22904065; 22910359; 23000965; 23012404; 23201127; 23398456; 23455922; 23456168; 24457600
description: transcription factor A, mitochondrial
database cross reference: Ensembl:ENSG00000108064
database cross reference: HGNC:11741
database cross reference: HPRD:02702
database cross reference: MIM:600438
database cross reference: Vega:OTTHUMG00000018270

TFCP2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LBP1C
alternative term: LSF
alternative term: LSF1D
alternative term: SEF
alternative term: TFCP2C
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TFCP2
full name from nomenclature authority: transcription factor CP2
NCBI GeneID: 7024
gene map location: 12q13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003677 (EC: IEA); GO_0003700 (EC: TAS, PMID: 8157699); GO_0005575 (EC: ND); GO_0005634 (EC: IEA); GO_0006351 (EC: IEA); GO_0006357 (EC: TAS, PMID: 8157699)
has PubMed association: PMID: 1732747; 7828600; 8035790; 8114710; 8157699; 8289393; 8586452; 9371597; 9685356; 10455131; 10888618; 11001930; 11003662; 11283204; 11574690; 11865070; 11884454; 11940654; 12393799; 12477932; 12555245; 12661759; 15489334; 15857981; 16169070; 16263792; 16272261; 16344560; 16648487; 16710089; 16713569; 16973241; 17456737; 17902044; 18164103; 18307033; 18629613; 18787404; 19471022; 19505873; 19889475; 19902333; 20195357; 20211142; 20404171; 20562859; 20661472; 21139048; 21703197; 21876634; 22167195; 22242598; 22396589
description: transcription factor CP2
database cross reference: Ensembl:ENSG00000135457
database cross reference: HGNC:11748
database cross reference: HPRD:01790
database cross reference: MIM:189889
database cross reference: Vega:OTTHUMG00000169621

TGM2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: G-ALPHA-h
alternative term: GNAH
alternative term: HEL-S-45
alternative term: TG2
alternative term: TGC
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TGM2
full name from nomenclature authority: transglutaminase 2
NCBI GeneID: 7052
NCBI LocusTag: RP5-1054A22.2
gene map location: 20q12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001974 (EC: IEA); GO_0003810 (EC: ISS); GO_0005515 (EC: IPI, PMID: 16301118); GO_0005525 (EC: IEA); GO_0005739 (EC: IEA); GO_0005886 (EC: IEA); GO_0018153 (EC: IEA); GO_0019904 (EC: IEA); GO_0043065 (EC: IEA); GO_0043123 (EC: IEA); GO_0043277 (EC: IDA, PMID: 19628791); GO_0045785 (EC: ISS); GO_0046872 (EC: IEA); GO_0048661 (EC: IEA); GO_0050729 (EC: IEA); GO_0051260 (EC: IEA); GO_0051482 (EC: IEA); GO_0060445 (EC: IEA); GO_0060662 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1353685; 1358880; 1670766; 1670773; 7688299; 7730416; 7906657; 7912692; 8611626; 9060478; 9252372; 9315663; 9442029; 9512491; 9973324; 10100610; 10518533; 10521459; 10556977; 10561600; 10611475; 10684262; 10922377; 10958788; 10963790; 11013236; 11258932; 11350930; 11390390; 11442349; 11686302; 11742196; 11762979; 11780052; 11829448; 11867708; 11867764; 12061780; 12093810; 12205028; 12368090; 12387450; 12410804; 12438565; 12477932; 12527383; 12528814; 12698366; 12743114; 12853457; 12960346; 14631123; 14747475; 14752105; 14985437; 15001552; 15069073; 15199098; 15201665; 15220331; 15231748; 15272014; 15362860; 15460447; 15471861; 15489334; 15556610; 15585642; 15592455; 15691824; 15715085; 15746535; 15752564; 15886239; 16146723; 16146727; 16146777; 16153302; 16212417; 16285941; 16300411; 16301118; 16313886; 16338459; 16368540; 16368554; 16382148; 16407273; 16439457; 16449978; 16522628; 16720350; 16757564; 16826431; 16914140; 16951195; 17043648; 17171363; 17189522; 17228174; 17314516; 17374730; 17403029; 17440814; 17442486; 17476115; 17609251; 17625111; 17671187; 17711877; 17762854; 17890909; 17924658; 17939176; 18052077; 18092889; 18174247; 18235007; 18312620; 18353867; 18375543; 18381937; 18474442; 18490773; 18499669; 18505736; 18544639; 18561261; 18584285; 18587533; 18632639; 18667446; 18673368; 18793760; 18804908; 18809380; 18849643; 18923241; 19013523; 19056867; 19182256; 19183553; 19278990; 19324884; 19342211; 19403524; 19542224; 19562471; 19619546; 19625650; 19628791; 19632032; 19655169; 19657147; 19680746; 19738201; 19756726; 19838207; 19840940; 19878304; 19912255; 19931242; 19937343; 20007697; 20033322; 20052409; 20080707; 20156196; 20371597; 20437185; 20450916; 20450932; 20488756; 20489165; 20547769; 20596752; 20615646; 20659425; 20665636; 20676023; 20717931; 20731657; 20731658; 20739659; 20874003; 20926141; 20929862; 20967228; 21036168; 21036738; 21124911; 21129482; 21139048; 21226238; 21252943; 21304968; 21359202; 21441900; 21525012; 21625219; 21678409;…
description: transglutaminase 2
database cross reference: Ensembl:ENSG00000198959
database cross reference: HGNC:11778
database cross reference: HPRD:01825
database cross reference: MIM:190196
database cross reference: Vega:OTTHUMG00000032437

TH
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DYT14
alternative term: DYT5b
alternative term: TYH
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TH
full name from nomenclature authority: tyrosine hydroxylase
NCBI GeneID: 7054
gene map location: 11p15.5
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001666 (EC: IDA, PMID: 17520326); GO_0001963 (EC: ISS); GO_0001975 (EC: IEA); GO_0003007 (EC: NAS, PMID: 12113410); GO_0004511 (EC: IDA, PMID: 11943812); GO_0004511 (EC: TAS); GO_0005515 (EC: IPI, PMID: 11943812); GO_0005634 (EC: ISS); GO_0005737 (EC: IDA, PMID: 10907721); GO_0005739 (EC: IEA); GO_0005790 (EC: IDA, PMID: 12457228); GO_0005829 (EC: TAS); GO_0006585 (EC: NAS, PMID: 10907721); GO_0006631 (EC: IEA); GO_0006665 (EC: IEA); GO_0007507 (EC: ISS); GO_0007601 (EC: ISS); GO_0007605 (EC: IEA); GO_0007612 (EC: ISS); GO_0007613 (EC: ISS); GO_0007617 (EC: IEA); GO_0007626 (EC: ISS); GO_0008016 (EC: ISS); GO_0008021 (EC: IEA); GO_0008198 (EC: IEA); GO_0008199 (EC: IEA); GO_0009414 (EC: IEA); GO_0009416 (EC: IEA); GO_0009635 (EC: IEA); GO_0009651 (EC: IEA); GO_0009653 (EC: TAS, PMID: 7715703); GO_0009887 (EC: ISS); GO_0009898 (EC: IDA, PMID: 12457228); GO_0010043 (EC: IEA); GO_0010259 (EC: IEA); GO_0014823 (EC: IEA); GO_0015842 (EC: IEA); GO_0016137 (EC: IEA); GO_0016597 (EC: IEA); GO_0018963 (EC: IEA); GO_0019825 (EC: IEA); GO_0019904 (EC: IEA); GO_0021987 (EC: IEA); GO_0030425 (EC: IEA); GO_0031410 (EC: IDA, PMID: 12457228); GO_0031667 (EC: IEA); GO_0032355 (EC: IEA); GO_0032496 (EC: IEA); GO_0033076 (EC: IEA); GO_0033162 (EC: IDA, PMID: 12631248); GO_0034617 (EC: IEA); GO_0034641 (EC: TAS); GO_0035176 (EC: IEA); GO_0035240 (EC: IEA); GO_0035690 (EC: IEA); GO_0042136 (EC: IEA); GO_0042214 (EC: IEA); GO_0042416 (EC: IDA, PMID: 12457228); GO_0042418 (EC: IDA, PMID: 12457228); GO_0042421 (EC: IDA, PMID: 12457228); GO_0042423 (EC: TAS); GO_0042462 (EC: ISS); GO_0042745 (EC: IEA); GO_0042755 (EC: IEA); GO_0043005 (EC: IDA, PMID: 17135716); GO_0043195 (EC: IEA); GO_0043204 (EC: ISS); GO_0043434 (EC: IEA); GO_0043473 (EC: TAS, PMID: 12631248); GO_0044281 (EC: TAS); GO_0045471 (EC: IDA, PMID: 18343820); GO_0045472 (EC: IEA); GO_0046684 (EC: IEA); GO_0048596 (EC: ISS); GO_0051412 (EC: IEA); GO_0051602 (EC: IEA); GO_0052314 (EC: IEA); GO_0071287 (EC: IEA); GO_0071316 (E…
has PubMed association: PMID: 33381; 1347949; 1973163; 2872999; 2874140; 2882428; 2887169; 2888085; 2892528; 2892893; 2896667; 2902075; 2905129; 6137760; 6150037; 7715703; 7789962; 7814018; 7901013; 8101641; 8528210; 8817341; 8889548; 9613851; 9703425; 9754624; 9920892; 10391209; 10660577; 10907721; 11246459; 11326301; 11359875; 11738155; 11834745; 11943812; 12113410; 12358785; 12421349; 12428766; 12457228; 12477932; 12493595; 12527603; 12571119; 12576454; 12610512; 12631248; 12759555; 12782971; 12891655; 14570886; 14651963; 14651989; 14675149; 14739699; 14749349; 15077008; 15135070; 15303408; 15468323; 15476168; 15722952; 15735319; 15736042; 15744773; 15898085; 15953356; 16139102; 16251897; 16252282; 16338639; 16344718; 16360899; 16445854; 16447258; 16516890; 16636198; 16643317; 16644734; 16731528; 16741719; 16764822; 16887311; 17018139; 17135716; 17194738; 17195153; 17329957; 17391063; 17466074; 17520326; 17698383; 17698732; 17784840; 17869399; 17926059; 17948905; 17972051; 17985144; 17988588; 18023073; 18058633; 18085551; 18181650; 18208403; 18270970; 18343820; 18534229; 18554280; 18574609; 18583979; 18814238; 18979915; 19120120; 19125082; 19156168; 19189602; 19221445; 19224593; 19285077; 19352218; 19360691; 19367319; 19448984; 19491146; 19491717; 19604093; 19674121; 19693267; 19703902; 19761814; 19767753; 19772578; 19801645; 19815691; 19833152; 19874574; 19913121; 19958792; 20046397; 20056467; 20067853; 20124442; 20132525; 20146650; 20163778; 20198643; 20301610; 20468064; 20564319; 20571875; 20602615; 20628086; 20646572; 20675101; 20706199; 20734064; 20809526; 20818075; 20838244; 20938049; 21083670; 21087208; 21158937; 21265843; 21368136; 21392500; 21407269; 21656370; 21815951; 22001923; 22002062; 22066143; 22083667; 22272358; 22336227; 22583432; 22691284; 22815559; 23182718; 23444366; 23481708; 23647419; 23762320; 23936387; 24055376; 24168553
description: tyrosine hydroxylase
database cross reference: Ensembl:ENSG00000180176
database cross reference: HGNC:11782
database cross reference: HPRD:01865
database cross reference: MIM:191290
database cross reference: Vega:OTTHUMG00000009559

THOP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: EP24.15
alternative term: MEPD_HUMAN
alternative term: MP78
alternative term: TOP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: THOP1
full name from nomenclature authority: thimet oligopeptidase 1
NCBI GeneID: 7064
gene map location: 19p13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004222 (EC: IEA); GO_0005515 (EC: IPI, PMID: 19614740); GO_0005737 (EC: IEA); GO_0006518 (EC: IEA); GO_0042277 (EC: IEA); GO_0046872 (EC: IEA)
has PubMed association: PMID: 7639763; 8286339; 8373360; 8824811; 9790774; 10415366; 10504294; 10541437; 10969067; 10993116; 11479311; 12477932; 12502762; 12648459; 14702039; 14998993; 15057824; 15231747; 15328361; 15376229; 15489334; 17251185; 18571100; 19282285; 19614740; 21139048; 21151101; 21890473; 21906983; 21963094; 22053931; 22796113; 22863883; 22939629; 23708739; 24250222
description: thimet oligopeptidase 1
database cross reference: Ensembl:ENSG00000172009
database cross reference: HGNC:11793
database cross reference: HPRD:03072
database cross reference: MIM:601117
database cross reference: Vega:OTTHUMG00000180492

THRA
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AR7
alternative term: CHNG6
alternative term: EAR7
alternative term: ERB-T-1
alternative term: ERBA
alternative term: ERBA1
alternative term: NR1A1
alternative term: THRA1
alternative term: THRA2
alternative term: c-ERBA-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: THRA
full name from nomenclature authority: thyroid hormone receptor, alpha
NCBI GeneID: 7067
gene map location: 17q11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001502 (EC: IEA); GO_0001503 (EC: IEA); GO_0002153 (EC: IEA); GO_0002155 (EC: IEA); GO_0003700 (EC: IDA, PMID: 18052923); GO_0003707 (EC: IEA); GO_0004887 (EC: IDA, PMID: 15466465); GO_0005515 (EC: IPI, PMID: 10866662); GO_0005634 (EC: IDA, PMID: 19158403); GO_0005654 (EC: TAS); GO_0005829 (EC: IDA, PMID: 19158403); GO_0006357 (EC: IDA, PMID: 18052923); GO_0006366 (EC: IDA, PMID: 8710870); GO_0006367 (EC: TAS); GO_0007611 (EC: IEA); GO_0008016 (EC: IEA); GO_0008050 (EC: IEA); GO_0008134 (EC: IPI, PMID: 8524305); GO_0008270 (EC: IEA); GO_0009409 (EC: IEA); GO_0009755 (EC: IDA, PMID: 18052923); GO_0010467 (EC: TAS); GO_0010831 (EC: IEA); GO_0017025 (EC: IDA, PMID: 8524305); GO_0017055 (EC: IDA, PMID: 8524305); GO_0019904 (EC: IPI, PMID: 9653119); GO_0030218 (EC: IEA); GO_0030878 (EC: IEA); GO_0031490 (EC: IEA); GO_0032403 (EC: IEA); GO_0033032 (EC: IEA); GO_0042994 (EC: IEA); GO_0043565 (EC: IEA); GO_0044212 (EC: IDA, PMID: 18052923); GO_0045892 (EC: IDA, PMID: 8710870); GO_0045925 (EC: IEA); GO_0045944 (EC: IEA); GO_0050994 (EC: IEA); GO_0060509 (EC: IEA); GO_0070324 (EC: IDA, PMID: 15466465); GO_0070324 (EC: IPI, PMID: 2879243); GO_2000143 (EC: IDA, PMID: 8524305)
has PubMed association: PMID: 1307263; 1314167; 1331778; 1517709; 1537303; 1850510; 2464749; 2539258; 2710139; 2879242; 2879243; 3357890; 3458521; 3672126; 3684612; 6323162; 6589608; 7566114; 7566127; 7609079; 7776974; 8036737; 8127707; 8524305; 8537364; 8616895; 8650544; 8710870; 8806651; 9115274; 9256431; 9267036; 9268132; 9405624; 9415406; 9440806; 9626662; 9627117; 9628876; 9653119; 9680361; 9717844; 9804773; 9849963; 10022432; 10037764; 10198638; 10207062; 10235266; 10379889; 10409738; 10480874; 10490654; 10508171; 10567404; 10610177; 10691735; 10733574; 10744685; 10847592; 10866662; 10877839; 10902817; 10903152; 10965896; 11117530; 11158331; 11266503; 11641275; 11713274; 11726557; 11861164; 11889044; 11889175; 12048199; 12082618; 12138181; 12231529; 12371907; 12388540; 12477932; 12805224; 12871948; 12874288; 12878587; 14576168; 14614212; 14729678; 15130509; 15131262; 15140878; 15249124; 15388935; 15466465; 15489334; 15604093; 15674337; 15757863; 15767343; 15802373; 15808511; 15941852; 16219912; 16781732; 16799563; 17065567; 17220280; 17242407; 17560756; 17577579; 17620012; 17641689; 17911173; 18052923; 18467449; 18562675; 18641393; 18655026; 18844476; 19144825; 19158403; 19360007; 19422879; 19427062; 19453261; 19519176; 19628582; 19730683; 19819978; 19853653; 19903799; 19926848; 20053725; 20141582; 20211142; 20231357; 20534741; 20691434; 20724312; 20736347; 21075170; 21389087; 21508093; 21529443; 21622534; 21654857; 21738480; 21868449; 21988832; 21997736; 22224817; 22930759; 23271024; 23300972; 23633213; 23940126; 24250222
description: thyroid hormone receptor, alpha
database cross reference: Ensembl:ENSG00000126351
database cross reference: HGNC:11796
database cross reference: HPRD:07185
database cross reference: MIM:190120
database cross reference: Vega:OTTHUMG00000133332

TIMP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CLGI
alternative term: EPA
alternative term: EPO
alternative term: HCI
alternative term: TIMP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TIMP1
full name from nomenclature authority: TIMP metallopeptidase inhibitor 1
NCBI GeneID: 7076
NCBI LocusTag: RP1-230G1.3
gene map location: Xp11.3-p11.23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002020 (EC: IEA); GO_0002576 (EC: TAS); GO_0005515 (EC: IPI, PMID: 16917503); GO_0005576 (EC: NAS, PMID: 1653055); GO_0005576 (EC: TAS); GO_0005604 (EC: IEA); GO_0007568 (EC: IEA); GO_0007596 (EC: TAS); GO_0008191 (EC: IDA, PMID: 12714508); GO_0008284 (EC: TAS, PMID: 3839290); GO_0010951 (EC: IDA, PMID: 12714508); GO_0022617 (EC: TAS); GO_0030168 (EC: TAS); GO_0030198 (EC: TAS); GO_0031093 (EC: TAS); GO_0034097 (EC: IEA); GO_0043066 (EC: IEA); GO_0043249 (EC: IEA); GO_0043434 (EC: IEA); GO_0046872 (EC: IEA); GO_0051045 (EC: IDA, PMID: 12714508); GO_1901164 (EC: IMP)
has PubMed association: PMID: 1420137; 1653055; 1730286; 2163605; 2171551; 2251898; 2921031; 3010309; 3460333; 3688834; 3839290; 3903517; 7507419; 8757599; 9063449; 9286280; 9288970; 9778693; 10071915; 10233411; 10441576; 10623524; 11279011; 11598182; 11606052; 11705862; 11762702; 11796725; 11876751; 11935340; 11940298; 12032189; 12034345; 12063180; 12081564; 12082592; 12147251; 12150976; 12218659; 12376362; 12406369; 12452001; 12475252; 12477932; 12479097; 12496489; 12538453; 12612199; 12614934; 12620441; 12626459; 12634064; 12651627; 12704667; 12714508; 12717827; 12771930; 12791318; 12834347; 12846741; 12861139; 12869573; 12873541; 12904305; 12921631; 12951656; 12970724; 14517716; 14605322; 14622947; 14630798; 14648584; 14652000; 14661256; 14669348; 14688084; 14710472; 14734567; 14871825; 14962256; 14973177; 14983226; 15028476; 15051730; 15073104; 15161657; 15225209; 15248826; 15277439; 15287862; 15313474; 15340161; 15363817; 15363818; 15465038; 15479729; 15485866; 15489334; 15494493; 15515157; 15516987; 15530852; 15557756; 15616792; 15754326; 15754388; 15797648; 15818737; 15841325; 15867221; 15888067; 15890357; 15896974; 15944607; 16005367; 16019435; 16042227; 16061701; 16100012; 16103240; 16107690; 16169070; 16188099; 16191301; 16219294; 16248458; 16263699; 16269968; 16280123; 16288711; 16289162; 16303743; 16335952; 16372907; 16407831; 16410344; 16474379; 16496359; 16555295; 16615041; 16631927; 16740002; 16754484; 16767366; 16772717; 16786122; 16840178; 16864898; 16877361; 16880228; 16917503; 16931892; 16935611; 16940985; 16960901; 16996520; 17008230; 17009408; 17012236; 17045024; 17050530; 17071711; 17072372; 17114213; 17136882; 17162914; 17182940; 17192464; 17202148; 17205957; 17209789; 17222415; 17226791; 17299802; 17301822; 17340613; 17350093; 17380436; 17409012; 17456311; 17478562; 17489740; 17493602; 17543340; 17549663; 17564313; 17572998; 17589947; 17634538; 17660250; 17703334; 17726014; 17763191; 17786346; 17878270; 17893005; 17899257; 17920311; 17928006; 17998244; 18025061; 18…
description: TIMP metallopeptidase inhibitor 1
database cross reference: Ensembl:ENSG00000102265
database cross reference: HGNC:11820
database cross reference: HPRD:02371
database cross reference: MIM:305370
database cross reference: Vega:OTTHUMG00000021447

TLR2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD282
alternative term: TIL4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TLR2
full name from nomenclature authority: toll-like receptor 2
NCBI GeneID: 7097
gene map location: 4q32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001666 (EC: IEA); GO_0001875 (EC: TAS, PMID: 11518816); GO_0002224 (EC: TAS); GO_0002238 (EC: IEA); GO_0002282 (EC: IEA); GO_0002687 (EC: IEA); GO_0002752 (EC: IEA); GO_0002755 (EC: TAS); GO_0004872 (EC: IDA, PMID: 11672593); GO_0004888 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10854325); GO_0005737 (EC: IDA, PMID: 19740627); GO_0005886 (EC: IDA, PMID: 19740627); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 9435236); GO_0006691 (EC: IEA); GO_0006915 (EC: TAS, PMID: 10426996); GO_0006954 (EC: IEA); GO_0006955 (EC: TAS, PMID: 10426995); GO_0007165 (EC: TAS, PMID: 11044375); GO_0007252 (EC: IDA, PMID: 19740627); GO_0008285 (EC: IEA); GO_0008329 (EC: IDA, PMID: 10384090); GO_0009636 (EC: IEA); GO_0009897 (EC: IEA); GO_0009986 (EC: IDA, PMID: 12443841); GO_0030177 (EC: IMP, PMID: 16601243); GO_0031663 (EC: TAS, PMID: 11518816); GO_0032289 (EC: IEA); GO_0032570 (EC: IEA); GO_0032695 (EC: IEA); GO_0032700 (EC: IEA); GO_0032722 (EC: IDA, PMID: 19740627); GO_0032728 (EC: ISS); GO_0032733 (EC: IEA); GO_0032735 (EC: ISS); GO_0032741 (EC: ISS); GO_0032755 (EC: IDA, PMID: 19740627); GO_0032757 (EC: IDA, PMID: 17128265); GO_0032760 (EC: ISS); GO_0032868 (EC: IEA); GO_0034123 (EC: IDA, PMID: 17128265); GO_0034134 (EC: TAS); GO_0034142 (EC: TAS); GO_0035354 (EC: IDA, PMID: 17889651); GO_0035355 (EC: IEA); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042346 (EC: IDA, PMID: 19740627); GO_0042495 (EC: IDA, PMID: 19931471); GO_0042496 (EC: IDA, PMID: 19931471); GO_0042497 (EC: IDA, PMID: 17889651); GO_0042498 (EC: IEA); GO_0042535 (EC: IEA); GO_0042834 (EC: IDA, PMID: 11986301); GO_0042892 (EC: IEA); GO_0042995 (EC: IEA); GO_0044130 (EC: IEA); GO_0044297 (EC: IEA); GO_0045087 (EC: TAS, PMID: 15356140); GO_0045429 (EC: IEA); GO_0045944 (EC: ISS); GO_0046209 (EC: IEA); GO_0046982 (EC: IDA, PMID: 17889651); GO_0048714 (EC: IEA); GO_0050715 (EC: IEA); GO_0050729 (EC: IC, PMID: 19740627); GO_0050830 (EC: IDA, PMID: 11521063); GO_0051092 (EC: IDA, PMID: 12594207); GO_0051770 (EC: ISS)…
has PubMed association: PMID: 9435236; 9596645; 9751057; 10384090; 10395652; 10426995; 10426996; 10548109; 10854325; 10963608; 11035751; 11044375; 11081518; 11101877; 11160242; 11222859; 11276206; 11441107; 11476982; 11477091; 11518816; 11521063; 11561001; 11672593; 11724772; 11751856; 11782555; 11836257; 11842086; 11867630; 11867688; 11877429; 11894098; 11912201; 11932927; 11986301; 12023360; 12061629; 12077222; 12089142; 12163593; 12171914; 12207338; 12270725; 12356755; 12397021; 12437972; 12438323; 12443841; 12445799; 12471095; 12477932; 12525572; 12538701; 12540550; 12588460; 12594207; 12630564; 12646604; 12651614; 12663765; 12734363; 12734376; 12810071; 12816980; 12817025; 12860988; 12874236; 12941697; 12942028; 12946842; 12958190; 12966099; 12975352; 14500665; 14551607; 14607814; 14625308; 14651524; 14662888; 14673018; 14694183; 14706103; 14706104; 14707104; 14709406; 14738464; 14966134; 14979495; 14981245; 14987294; 15007072; 15007351; 15007364; 15041961; 15044215; 15064239; 15107846; 15138193; 15146245; 15146246; 15146415; 15148609; 15155685; 15173186; 15175649; 15210811; 15214053; 15247273; 15247281; 15272059; 15276183; 15305230; 15319868; 15321997; 15322009; 15342637; 15356140; 15385480; 15456896; 15489334; 15489631; 15496409; 15501775; 15516360; 15521019; 15539529; 15583145; 15585865; 15657077; 15670752; 15670766; 15696084; 15699513; 15717270; 15726416; 15728506; 15731031; 15731043; 15731050; 15753758; 15760452; 15760459; 15778388; 15790341; 15793154; 15814732; 15864780; 15875151; 15910421; 15919371; 15955814; 15968536; 16002719; 16004610; 16024789; 16034117; 16035096; 16081826; 16107886; 16115866; 16146574; 16177110; 16179594; 16213463; 16230348; 16239565; 16242370; 16267105; 16270639; 16283346; 16290232; 16293622; 16336272; 16371473; 16374251; 16437124; 16439361; 16443229; 16455995; 16478769; 16482509; 16484229; 16497887; 16514159; 16517732; 16551363; 16601243; 16606450; 16608528; 16621981; 16629651; 16648973; 16712654; 16731773; 16751412; 16754684; 16754688; 16766226; 1676722…
description: toll-like receptor 2
database cross reference: HGNC:11848
database cross reference: HPRD:04323
database cross reference: MIM:603028

TLR3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD283
alternative term: IIAE2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TLR3
full name from nomenclature authority: toll-like receptor 3
NCBI GeneID: 7098
gene map location: 4q35
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: TAS); GO_0002224 (EC: TAS); GO_0002282 (EC: IEA); GO_0002756 (EC: TAS); GO_0003725 (EC: IDA, PMID: 16111635); GO_0003725 (EC: NAS, PMID: 12054664); GO_0004872 (EC: TAS, PMID: 10426995); GO_0004888 (EC: NAS, PMID: 12054664); GO_0005515 (EC: IPI, PMID: 16858407); GO_0005737 (EC: IDA, PMID: 19740627); GO_0005765 (EC: IDA, PMID: 17897319); GO_0005789 (EC: TAS); GO_0005887 (EC: TAS, PMID: 9435236); GO_0006954 (EC: IEA); GO_0006972 (EC: NAS, PMID: 12054664); GO_0007165 (EC: TAS, PMID: 10426995); GO_0007249 (EC: TAS); GO_0007250 (EC: NAS, PMID: 12054664); GO_0007252 (EC: IDA, PMID: 19740627); GO_0008584 (EC: IEA); GO_0009597 (EC: NAS, PMID: 12054664); GO_0009986 (EC: IDA, Qualifier: NOT, PMID: 19740627); GO_0010008 (EC: TAS); GO_0016020 (EC: NAS, PMID: 12054664); GO_0032722 (EC: IDA, PMID: 19740627); GO_0032728 (EC: ISS); GO_0032735 (EC: ISS); GO_0032755 (EC: IDA, PMID: 19740627); GO_0032757 (EC: IDA, PMID: 17128265); GO_0032760 (EC: ISS); GO_0034123 (EC: IDA, PMID: 17128265); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034346 (EC: IEA); GO_0035458 (EC: IEA); GO_0035666 (EC: TAS); GO_0035690 (EC: IEA); GO_0036020 (EC: TAS); GO_0042346 (EC: IDA, PMID: 19740627); GO_0042742 (EC: TAS, PMID: 10426995); GO_0043065 (EC: IEA); GO_0043123 (EC: IEA); GO_0043330 (EC: IDA); GO_0045078 (EC: IDA, PMID: 16286015); GO_0045080 (EC: IEA); GO_0045087 (EC: TAS, PMID: 15356140); GO_0045356 (EC: IDA, PMID: 16286015); GO_0045359 (EC: IDA, PMID: 16286015); GO_0045359 (EC: IMP, PMID: 12054664); GO_0045671 (EC: NAS, PMID: 12133979); GO_0045944 (EC: ISS); GO_0046330 (EC: IEA); GO_0050729 (EC: IC, PMID: 19740627); GO_0051092 (EC: IEA); GO_0051607 (EC: TAS, PMID: 15356140); GO_0052033 (EC: IEA); GO_0071260 (EC: IEP, PMID: 19593445); GO_0071346 (EC: IEA); GO_0071360 (EC: IEA); GO_0097191 (EC: IDA); GO_0097527 (EC: IDA)
has PubMed association: PMID: 9435236; 10066798; 10426995; 10820283; 11561001; 11607032; 11782555; 12054664; 12133979; 12477932; 12509442; 12539043; 12609980; 12646618; 12672806; 12692549; 12855817; 14519765; 14557267; 14575692; 14729660; 14982987; 14987294; 15064760; 15107846; 15119015; 15153468; 15212709; 15226270; 15315972; 15340161; 15356140; 15502848; 15579900; 15652398; 15731229; 15737993; 15767394; 15778392; 15845391; 15935884; 15961631; 15972671; 16029432; 16035096; 16043704; 16111635; 16115877; 16144834; 16146574; 16160153; 16286015; 16289658; 16293707; 16344560; 16399790; 16424203; 16473828; 16482523; 16484229; 16533755; 16585585; 16628196; 16720699; 16847112; 16858407; 16877304; 16914605; 16935934; 16950283; 17043099; 17085778; 17128265; 17142768; 17142772; 17150911; 17178723; 17209042; 17254392; 17292969; 17301562; 17314152; 17434873; 17449641; 17521732; 17525119; 17534115; 17573354; 17602875; 17626075; 17660379; 17703412; 17786279; 17805015; 17851256; 17872438; 17878161; 17897319; 17908959; 17939877; 17947455; 17962643; 17962701; 17963596; 17964520; 17982077; 18021446; 18029758; 18172197; 18204787; 18253710; 18262679; 18325643; 18367536; 18385087; 18394314; 18437017; 18442983; 18508883; 18541719; 18544529; 18562533; 18566014; 18566393; 18568036; 18684960; 18686608; 18715647; 18725521; 18753640; 18775079; 18776324; 18776592; 18779317; 18810425; 18813073; 18818748; 18832709; 18849495; 18946062; 18949355; 18978302; 18988918; 19001446; 19016379; 19019335; 19035519; 19055649; 19120481; 19134117; 19164128; 19231996; 19234180; 19247444; 19254290; 19258923; 19265130; 19299748; 19362356; 19378782; 19423540; 19437550; 19475618; 19494321; 19505919; 19522763; 19527514; 19542247; 19593445; 19597128; 19625408; 19628747; 19631980; 19646728; 19656899; 19740627; 19741468; 19748983; 19752565; 19758322; 19769802; 19779021; 19795416; 19810822; 19833099; 19855253; 19878930; 19887600; 19890046; 19902255; 19914718; 19948350; 19951172; 19966137; 19966777; 20009359; 20047764; 20100933; 20124101; 20194…
description: toll-like receptor 3
database cross reference: HGNC:11849
database cross reference: HPRD:04324
database cross reference: MIM:603029

TLR4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ARMD10
alternative term: CD284
alternative term: TLR-4
alternative term: TOLL
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TLR4
full name from nomenclature authority: toll-like receptor 4
NCBI GeneID: 7099
gene map location: 9q33.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: ISS); GO_0001530 (EC: IMP, PMID: 16514062); GO_0001530 (EC: NAS, PMID: 10835634); GO_0001875 (EC: IDA, PMID: 19252480); GO_0002224 (EC: TAS); GO_0002322 (EC: IEA); GO_0002537 (EC: IEA); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0004872 (EC: TAS, PMID: 10426995); GO_0004888 (EC: NAS, PMID: 11970998); GO_0005515 (EC: IPI, PMID: 11441107); GO_0005737 (EC: IDA, PMID: 19740627); GO_0005886 (EC: IDA, PMID: 19740627); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 15027902); GO_0006955 (EC: TAS, PMID: 10426995); GO_0007249 (EC: TAS); GO_0007252 (EC: IDA, PMID: 19740627); GO_0009897 (EC: IDA, PMID: 16514062); GO_0010008 (EC: TAS); GO_0010572 (EC: ISS, PMID: 16514062); GO_0016046 (EC: NAS, PMID: 11254600); GO_0030890 (EC: IEA); GO_0031663 (EC: IDA, Qualifier: NOT, PMID: 10880523); GO_0031663 (EC: IGI, PMID: 10880523); GO_0032496 (EC: IC, PMID: 16514062); GO_0032496 (EC: IDA, PMID: 12594207); GO_0032497 (EC: IDA, PMID: 19252480); GO_0032609 (EC: IEA); GO_0032689 (EC: ISS); GO_0032700 (EC: ISS); GO_0032707 (EC: ISS); GO_0032715 (EC: ISS); GO_0032720 (EC: ISS); GO_0032722 (EC: IDA, PMID: 19740627); GO_0032727 (EC: ISS); GO_0032728 (EC: ISS); GO_0032729 (EC: ISS); GO_0032732 (EC: ISS); GO_0032733 (EC: ISS); GO_0032735 (EC: ISS); GO_0032755 (EC: IDA, PMID: 19740627); GO_0032757 (EC: IDA, PMID: 19740627); GO_0032760 (EC: ISS); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0035666 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042088 (EC: NAS, PMID: 11970998); GO_0042116 (EC: IMP, PMID: 10835634); GO_0042346 (EC: IDA, PMID: 19740627); GO_0042535 (EC: IDA, PMID: 17951129); GO_0042742 (EC: TAS, PMID: 10426995); GO_0043123 (EC: IEA); GO_0045084 (EC: IDA, PMID: 15027902); GO_0045087 (EC: TAS, PMID: 15356140); GO_0045348 (EC: IEA); GO_0045359 (EC: IEA); GO_0045416 (EC: IDA, PMID: 17951129); GO_0045429 (EC: IEA); GO_0045671 (EC: NAS, PMID: 12133979); GO_0045944 (EC: ISS); GO_0046330 (EC: IEA); GO_0046696 (EC: IDA, PMID: 19252480);…
has PubMed association: PMID: 9237759; 9435236; 9625770; 10359581; 10426995; 10465784; 10524757; 10734131; 10835634; 10880523; 10952994; 11081518; 11104518; 11254600; 11441107; 11466383; 11477091; 11490012; 11494169; 11514453; 11526399; 11529488; 11544529; 11561001; 11688988; 11706042; 11728442; 11743586; 11751856; 11782555; 11835533; 11836257; 11841848; 11842086; 11877429; 11893689; 11912201; 11923281; 11932926; 11932927; 11964313; 11970998; 11976338; 12045108; 12055604; 12089142; 12117914; 12124407; 12133979; 12165534; 12174084; 12193670; 12196527; 12270725; 12324469; 12324481; 12391239; 12397216; 12402214; 12404174; 12406828; 12411706; 12438323; 12444143; 12447442; 12477932; 12477953; 12495941; 12525572; 12552467; 12588460; 12591474; 12592402; 12594207; 12599057; 12622779; 12630564; 12646618; 12717385; 12724322; 12730365; 12734376; 12738639; 12742999; 12773175; 12773319; 12777373; 12782302; 12794153; 12796470; 12810071; 12832426; 12846053; 12855579; 12865424; 12874320; 12897738; 12923493; 12925853; 12941697; 12942028; 12957699; 12960171; 12964127; 14517278; 14519765; 14551607; 14556004; 14557267; 14563652; 14565959; 14578307; 14597728; 14600154; 14610481; 14625308; 14638766; 14651524; 14693986; 14699116; 14699155; 14706103; 14709406; 14715415; 14735148; 14738464; 14739370; 14764071; 14764599; 14987294; 15007351; 15016407; 15022344; 15027902; 15039334; 15041961; 15044215; 15069085; 15081257; 15087412; 15107846; 15132988; 15138173; 15143473; 15148609; 15155619; 15175334; 15175649; 15187145; 15190267; 15194649; 15207785; 15213237; 15225640; 15247281; 15258789; 15273551; 15276183; 15277575; 15292002; 15302104; 15305230; 15321997; 15337750; 15340161; 15341923; 15351720; 15356101; 15356140; 15356557; 15358455; 15367917; 15373967; 15385480; 15452251; 15456896; 15489631; 15509550; 15516360; 15520404; 15525557; 15528333; 15547160; 15557191; 15576653; 15591473; 15610077; 15614130; 15623538; 15632890; 15644417; 15647432; 15650037; 15655821; 15661045; 15665723; 15670831; 15691841; 15694388; 1569531…
description: toll-like receptor 4
database cross reference: Ensembl:ENSG00000136869
database cross reference: HGNC:11850
database cross reference: HPRD:04325
database cross reference: MIM:603030
database cross reference: Vega:OTTHUMG00000021046

TNF
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DIF
alternative term: TNF-alpha
alternative term: TNFA
alternative term: TNFSF2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TNF
full name from nomenclature authority: tumor necrosis factor
NCBI GeneID: 7124
NCBI LocusTag: DADB-70P7.1
gene map location: 6p21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000060 (EC: IDA, PMID: 16280327); GO_0000122 (EC: IDA, PMID: 15345745); GO_0000165 (EC: IMP); GO_0000185 (EC: IDA, PMID: 15310755); GO_0000187 (EC: IDA, PMID: 10748004); GO_0001666 (EC: IEA); GO_0001775 (EC: IEA); GO_0001819 (EC: IDA, PMID: 17922812); GO_0001891 (EC: ISS); GO_0001934 (EC: IDA, PMID: 10748004); GO_0002020 (EC: IPI, PMID: 12777399); GO_0002037 (EC: IEA); GO_0002439 (EC: IMP, PMID: 14512626); GO_0002740 (EC: IDA, PMID: 10443688); GO_0002876 (EC: IEA); GO_0002925 (EC: IEA); GO_0003009 (EC: IEA); GO_0005125 (EC: IDA, PMID: 10748004); GO_0005164 (EC: IDA, PMID: 14512626); GO_0005515 (EC: IPI, PMID: 11878931); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 10443688); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 18355445); GO_0006006 (EC: IEA); GO_0006915 (EC: TAS); GO_0006919 (EC: IDA, PMID: 16723520); GO_0006927 (EC: IDA, PMID: 3883195); GO_0006954 (EC: IDA, PMID: 10748004); GO_0006959 (EC: IEA); GO_0007254 (EC: IEA); GO_0008285 (EC: IEA); GO_0008625 (EC: IDA, PMID: 10521396); GO_0008625 (EC: NAS); GO_0008630 (EC: IEA); GO_0008652 (EC: IEA); GO_0009612 (EC: IEA); GO_0009615 (EC: IDA, PMID: 10490959); GO_0009651 (EC: TAS, PMID: 18355445); GO_0009887 (EC: IEA); GO_0009897 (EC: ISS); GO_0009986 (EC: IDA, PMID: 18355445); GO_0010629 (EC: IDA, PMID: 15345745); GO_0010693 (EC: IEA); GO_0010888 (EC: NAS, PMID: 16464856); GO_0014823 (EC: IEA); GO_0019722 (EC: IEA); GO_0030198 (EC: IEA); GO_0030316 (EC: IEA); GO_0030730 (EC: IDA, PMID: 19032770); GO_0031334 (EC: IDA, PMID: 12813029); GO_0031622 (EC: ISS); GO_0031663 (EC: IDA); GO_0032715 (EC: IDA, PMID: 10443688); GO_0032722 (EC: IDA, PMID: 10490959); GO_0032729 (EC: IEA); GO_0032741 (EC: IEA); GO_0032755 (EC: IEA); GO_0032800 (EC: IDA, PMID: 10443688); GO_0033138 (EC: IDA, PMID: 17389591); GO_0033209 (EC: IMP, PMID: 10748004); GO_0034116 (EC: IDA, PMID: 10604883); GO_0042346 (EC: IDA, PMID: 17922812); GO_0042493 (EC: IEA); GO_0042802 (EC: IDA, PMID: 14512626); GO_0043065 (EC: IDA, PMID: 16723520); GO_00…
has PubMed association: PMID: 1279199; 1310388; 1331108; 1380260; 1402651; 1548758; 1550865; 1690216; 1905933; 1918997; 1918999; 1964681; 1993354; 2009860; 2158863; 2170559; 2413547; 2537468; 2551905; 2848815; 2922050; 2995927; 3001529; 3031624; 3139842; 3351931; 3417634; 3464978; 3552045; 3555974; 3856324; 3883195; 3932069; 6392892; 7494249; 7511078; 7523444; 7526541; 7536422; 7561697; 7664431; 7693046; 7695626; 7704970; 7706435; 7739525; 7758105; 7815507; 7818827; 7852363; 7859743; 7930591; 7935762; 7966397; 8182064; 8267288; 8288897; 8336080; 8336118; 8381971; 8383325; 8482849; 8499947; 8590321; 8597870; 8707350; 8724035; 8764000; 8806809; 8852605; 8869635; 8870842; 9034191; 9108403; 9110146; 9223523; 9225992; 9226228; 9230816; 9269771; 9269777; 9278385; 9334723; 9344703; 9378998; 9438495; 9442056; 9449720; 9488135; 9552007; 9568681; 9639071; 9651389; 9658081; 9670843; 9730685; 9744279; 9828130; 9920899; 10202016; 10205166; 10339575; 10369255; 10376933; 10383454; 10388525; 10415019; 10438928; 10443688; 10450718; 10490959; 10521396; 10604883; 10634209; 10666185; 10669763; 10747938; 10748004; 10775602; 10799478; 10820279; 10839541; 10843712; 10929056; 10964543; 11000208; 11023480; 11023482; 11023485; 11035665; 11037831; 11045789; 11057907; 11072751; 11083263; 11092520; 11097747; 11101870; 11106199; 11113269; 11118029; 11120931; 11121160; 11138328; 11144293; 11145126; 11153078; 11153913; 11157631; 11163081; 11163083; 11165717; 11167813; 11176446; 11179110; 11179116; 11192323; 11196671; 11196686; 11199329; 11211945; 11223972; 11230752; 11233912; 11241233; 11243953; 11244489; 11246532; 11250044; 11257271; 11258696; 11264025; 11266856; 11266927; 11266928; 11267084; 11273064; 11278695; 11285131; 11294926; 11298547; 11316066; 11316069; 11319038; 11319647; 11319665; 11324946; 11325850; 11328953; 11334675; 11349201; 11354638; 11371414; 11379335; 11389006; 11391238; 11401868; 11401880; 11404167; 11409121; 11411907; 11423177; 11427627; 11453117; 11500363; 11506397; 11506478; 11508580; 11522182; 115…
description: tumor necrosis factor
database cross reference: Ensembl:ENSG00000232810
database cross reference: HGNC:11892
database cross reference: HPRD:01855
database cross reference: MIM:191160
database cross reference: Vega:OTTHUMG00000031194

TNFAIP2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: B94
alternative term: EXOC3L3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TNFAIP2
full name from nomenclature authority: tumor necrosis factor, alpha-induced protein 2
NCBI GeneID: 7127
gene map location: 14q32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 14
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000145 (EC: IEA); GO_0001525 (EC: IEA); GO_0005615 (EC: TAS, PMID: 1374453); GO_0006887 (EC: IEA); GO_0030154 (EC: IEA)
has PubMed association: PMID: 1374453; 8106408; 10766166; 12477932; 19339270; 19913121; 20157331; 20237496; 20628086; 20628624; 21057457; 21139048; 21399635; 21555518; 21921781; 21934093; 22797925; 22939629; 23438482; 23724109
description: tumor necrosis factor, alpha-induced protein 2
database cross reference: Ensembl:ENSG00000185215
database cross reference: HGNC:11895
database cross reference: HPRD:04487
database cross reference: MIM:603300
database cross reference: Vega:OTTHUMG00000171890

TNFRSF1A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD120a
alternative term: FPF
alternative term: MS5
alternative term: TBP1
alternative term: TNF-R
alternative term: TNF-R-I
alternative term: TNF-R55
alternative term: TNFAR
alternative term: TNFR1
alternative term: TNFR1-d2
alternative term: TNFR55
alternative term: TNFR60
alternative term: p55
alternative term: p55-R
alternative term: p60
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TNFRSF1A
full name from nomenclature authority: tumor necrosis factor receptor superfamily, member 1A
NCBI GeneID: 7132
gene map location: 12p13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: IDA); GO_0001666 (EC: IEA); GO_0002020 (EC: IEA); GO_0005031 (EC: TAS, PMID: 2158863); GO_0005515 (EC: IPI, PMID: 10848577); GO_0005576 (EC: NAS, PMID: 12189246); GO_0005615 (EC: IDA, PMID: 13130484); GO_0005634 (EC: IEA); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 1698610); GO_0006693 (EC: IEA); GO_0006915 (EC: TAS); GO_0006954 (EC: ISS); GO_0008625 (EC: TAS, PMID: 8612133); GO_0008630 (EC: IEA); GO_0009986 (EC: IEA); GO_0010629 (EC: IEA); GO_0016032 (EC: IEA); GO_0019221 (EC: ISS); GO_0030424 (EC: IEA); GO_0032403 (EC: IEA); GO_0032496 (EC: IEA); GO_0032715 (EC: IEA); GO_0032760 (EC: IEA); GO_0033013 (EC: IEA); GO_0033160 (EC: IEA); GO_0042511 (EC: IMP); GO_0042742 (EC: IEA); GO_0043066 (EC: IEA); GO_0043120 (EC: IEA); GO_0043123 (EC: IEP, PMID: 12761501); GO_0043200 (EC: IEA); GO_0043235 (EC: IDA); GO_0043279 (EC: IEA); GO_0045121 (EC: IDA, PMID: 17010968); GO_0045471 (EC: IEA); GO_0045766 (EC: IEA); GO_0045944 (EC: IMP); GO_0045944 (EC: ISS); GO_0050728 (EC: IMP, PMID: 13130484); GO_0050729 (EC: ISS); GO_0051291 (EC: IEA); GO_0071260 (EC: IEP, PMID: 19593445); GO_0071392 (EC: IEA); GO_0097190 (EC: TAS)
has PubMed association: PMID: 1087798; 1310388; 1315717; 1331108; 1648547; 1655358; 1698610; 1702293; 2153136; 2158862; 2158863; 2170559; 2170974; 2848815; 3001529; 7156325; 7601280; 7664431; 7758105; 7852363; 7859281; 7876093; 7901149; 7995952; 8077196; 8182064; 8288897; 8387891; 8565075; 8612133; 8621670; 8808629; 8906799; 8934525; 8939750; 8943045; 8985253; 9038203; 9045686; 9082980; 9115275; 9126987; 9215629; 9237663; 9510175; 9557650; 9560245; 9563508; 9568681; 9585614; 9642260; 9753329; 9915703; 10187798; 10187805; 10199409; 10339433; 10356400; 10359574; 10400625; 10634209; 10706119; 10755617; 10848577; 10875917; 10902757; 10911999; 11002417; 11002422; 11035039; 11072751; 11078718; 11098060; 11163081; 11175303; 11196686; 11212177; 11226577; 11443543; 11522182; 11528523; 11562425; 11598334; 11606045; 11676596; 11684708; 11737221; 11755217; 11786908; 11801527; 11821416; 11861282; 11882518; 11904678; 11909948; 11920568; 11934887; 11937569; 11947900; 11961180; 11985495; 12017295; 12040173; 12049175; 12082592; 12105243; 12107724; 12115625; 12147741; 12189246; 12209507; 12209523; 12220546; 12353079; 12376300; 12391233; 12477932; 12500222; 12530121; 12559634; 12601524; 12610052; 12644782; 12651071; 12661999; 12690082; 12706861; 12730509; 12748169; 12748171; 12753742; 12761501; 12768019; 12786601; 12811828; 12818408; 12832748; 12858434; 12879482; 12887914; 12887920; 12911633; 12913922; 13130484; 14585990; 14610673; 14671137; 14694358; 14702039; 14728878; 14743216; 14872483; 15018649; 15041705; 15063762; 15071491; 15146559; 15188372; 15247912; 15251454; 15274667; 15288471; 15289829; 15301860; 15310755; 15457442; 15465831; 15485837; 15489334; 15492850; 15502938; 15526005; 15542843; 15586174; 15659383; 15692984; 15707590; 15743837; 15787661; 15817701; 15818692; 15842589; 15851552; 15943902; 15949439; 16043718; 16043808; 16115877; 16134057; 16142859; 16153798; 16195372; 16216134; 16227624; 16234278; 16260783; 16277675; 16282562; 16289162; 16291755; 16344560; 16447098; 16463024; 16533817; 1658022…
description: tumor necrosis factor receptor superfamily, member 1A
database cross reference: Ensembl:ENSG00000067182
database cross reference: HGNC:11916
database cross reference: HPRD:01861
database cross reference: MIM:191190
database cross reference: Vega:OTTHUMG00000168267

TP53
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BCC7
alternative term: LFS1
alternative term: P53
alternative term: TRP53
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TP53
full name from nomenclature authority: tumor protein p53
NCBI GeneID: 7157
gene map location: 17p13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000060 (EC: IEA); GO_0000122 (EC: IBA); GO_0000122 (EC: IDA, PMID: 15340061); GO_0000122 (EC: ISS, PMID: 19749791); GO_0000733 (EC: IDA, PMID: 8183576); GO_0000785 (EC: IBA); GO_0000790 (EC: IDA, PMID: 15710329); GO_0000979 (EC: IEA); GO_0001077 (EC: IEA); GO_0001085 (EC: IPI, PMID: 18549481); GO_0001228 (EC: IDA, PMID: 17146433); GO_0001701 (EC: IEA); GO_0001756 (EC: IEA); GO_0001836 (EC: IEA); GO_0002020 (EC: IPI, PMID: 11923872); GO_0002039 (EC: IBA); GO_0002309 (EC: IEA); GO_0002326 (EC: IEA); GO_0002360 (EC: IEA); GO_0002931 (EC: IEA); GO_0003677 (EC: IMP, PMID: 2144364); GO_0003682 (EC: IDA, PMID: 16322561); GO_0003684 (EC: IBA); GO_0003700 (EC: IDA, PMID: 18549481); GO_0005507 (EC: IDA, PMID: 7824276); GO_0005515 (EC: IPI, PMID: 10196247); GO_0005524 (EC: IDA, PMID: 8183576); GO_0005634 (EC: IDA); GO_0005654 (EC: IDA, PMID: 11080164); GO_0005654 (EC: TAS); GO_0005657 (EC: IBA); GO_0005669 (EC: IDA, Qualifier: colocalizes_with, PMID: 15053879); GO_0005730 (EC: IDA, PMID: 12080348); GO_0005737 (EC: IDA, PMID: 14744935); GO_0005739 (EC: IDA, PMID: 12667443); GO_0005759 (EC: IEA); GO_0005783 (EC: IEA); GO_0005829 (EC: IBA); GO_0005829 (EC: IDA, PMID: 14963330); GO_0006284 (EC: TAS, PMID: 15116721); GO_0006289 (EC: IMP, PMID: 7663514); GO_0006302 (EC: IEA); GO_0006355 (EC: IDA, PMID: 7587074); GO_0006461 (EC: IDA, PMID: 12915590); GO_0006915 (EC: TAS); GO_0006974 (EC: IDA, PMID: 14744935); GO_0006977 (EC: TAS); GO_0006978 (EC: IMP, PMID: 7958916); GO_0006983 (EC: IDA, PMID: 14744935); GO_0007050 (EC: IDA, PMID: 15149599); GO_0007050 (EC: IMP, PMID: 10962037); GO_0007179 (EC: IEA); GO_0007219 (EC: TAS); GO_0007265 (EC: IEP, PMID: 9054499); GO_0007275 (EC: IMP, PMID: 10065150); GO_0007369 (EC: IEA); GO_0007406 (EC: IEA); GO_0007417 (EC: IEA); GO_0007569 (EC: IMP, PMID: 12080348); GO_0007596 (EC: TAS); GO_0008104 (EC: IDA, PMID: 16507995); GO_0008134 (EC: IPI, PMID: 15053879); GO_0008156 (EC: IEA); GO_0008270 (EC: TAS, PMID: 10065153); GO_0008283 (EC: TAS, PMID: …
has PubMed association: PMID: 1088347; 1303181; 1327751; 1349102; 1349175; 1394225; 1437144; 1454855; 1459726; 1465435; 1565143; 1565144; 1591732; 1600943; 1631137; 1631151; 1644930; 1647768; 1672732; 1673792; 1679237; 1683921; 1694291; 1699228; 1705009; 1737852; 1762941; 1848668; 1849234; 1868473; 1905840; 1915267; 1933902; 1939648; 1978757; 1999338; 2047879; 2141171; 2144364; 2156209; 2259385; 2263646; 2531845; 2839831; 2905688; 2946935; 2994241; 3001719; 3025664; 3456488; 3894933; 4006916; 6396087; 7587074; 7663514; 7682763; 7686617; 7720704; 7753047; 7761466; 7773777; 7777531; 7799929; 7809597; 7811761; 7818536; 7824276; 7853525; 7878469; 7887414; 7935417; 7935455; 7958916; 8013454; 8016121; 8023157; 8023159; 8028670; 8058315; 8090726; 8118819; 8125298; 8134127; 8183576; 8207805; 8221626; 8266092; 8316628; 8336944; 8361542; 8364550; 8380895; 8389468; 8401536; 8402617; 8423216; 8463313; 8513440; 8612585; 8617246; 8619474; 8623534; 8623910; 8632903; 8632915; 8639538; 8649785; 8668206; 8675009; 8729618; 8816502; 8825920; 8829627; 8829653; 8875926; 8875929; 8895579; 8921390; 8940078; 8943363; 8961277; 8986812; 9010216; 9054499; 9101296; 9110174; 9119221; 9129988; 9135004; 9143503; 9183006; 9194564; 9194565; 9215863; 9223638; 9226370; 9235949; 9278461; 9288740; 9288775; 9312058; 9312059; 9315650; 9321402; 9349507; 9363941; 9369221; 9372954; 9380510; 9393873; 9405613; 9419979; 9440695; 9444950; 9450901; 9472015; 9472029; 9482880; 9492043; 9514881; 9520163; 9529249; 9537326; 9556563; 9565608; 9569035; 9571186; 9582019; 9582267; 9620776; 9628871; 9653180; 9679063; 9685344; 9688277; 9724636; 9724739; 9732264; 9744860; 9765199; 9809062; 9811893; 9827557; 9837938; 9840937; 9843217; 9891054; 9891077; 9926942; 9935181; 10024883; 10065150; 10065153; 10078201; 10196247; 10198638; 10214938; 10347180; 10348343; 10358050; 10359315; 10360174; 10380882; 10415337; 10435622; 10468612; 10470151; 10477429; 10484981; 10518217; 10521394; 10544138; 10551785; 10557093; 10562557; 10597287; 10606744; 10608806; 1060…
description: tumor protein p53
database cross reference: Ensembl:ENSG00000141510
database cross reference: HGNC:11998
database cross reference: HPRD:01859
database cross reference: MIM:191170
database cross reference: Vega:OTTHUMG00000162125

TRAF2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MGC:45012
alternative term: TRAP
alternative term: TRAP3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TRAF2
full name from nomenclature authority: TNF receptor-associated factor 2
NCBI GeneID: 7186
gene map location: 9q34
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002726 (EC: IMP, PMID: 15125833); GO_0004842 (EC: IDA, PMID: 15258597); GO_0004871 (EC: NAS, PMID: 8702708); GO_0005164 (EC: IPI, PMID: 11279055); GO_0005174 (EC: ISS); GO_0005515 (EC: IPI, PMID: 10514511); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0005938 (EC: IEA); GO_0006461 (EC: TAS, PMID: 8702708); GO_0006915 (EC: TAS); GO_0006919 (EC: TAS); GO_0007165 (EC: TAS, PMID: 8702708); GO_0007250 (EC: IMP, PMID: 15125833); GO_0008270 (EC: IEA); GO_0009898 (EC: ISS); GO_0019899 (EC: IPI, PMID: 16636664); GO_0019903 (EC: IPI, PMID: 15696169); GO_0030163 (EC: IEA); GO_0031435 (EC: IEA); GO_0031625 (EC: IPI, PMID: 11279055); GO_0031996 (EC: IPI, PMID: 11279055); GO_0032403 (EC: IEA); GO_0032743 (EC: IMP, PMID: 15125833); GO_0033209 (EC: IDA, PMID: 11907583); GO_0034351 (EC: IEA); GO_0035631 (EC: ISS); GO_0042802 (EC: IPI, PMID: 16189514); GO_0042981 (EC: IDA, PMID: 11907583); GO_0043507 (EC: IDA, PMID: 11907583); GO_0043623 (EC: ISS); GO_0045087 (EC: TAS); GO_0045121 (EC: IEA); GO_0046625 (EC: IDA); GO_0050870 (EC: IC, PMID: 15125833); GO_0051023 (EC: IEA); GO_0051091 (EC: IMP, PMID: 12296995); GO_0051092 (EC: IDA, PMID: 11279055); GO_0051092 (EC: IMP, PMID: 12296995); GO_0051291 (EC: IEA); GO_0051865 (EC: IDA); GO_0051865 (EC: TAS, PMID: 16378096); GO_0070207 (EC: IPI); GO_0070534 (EC: IDA, PMID: 15258597); GO_0090073 (EC: IMP, PMID: 11278723); GO_0097190 (EC: TAS); GO_2001238 (EC: IMP); GO_2001239 (EC: TAS)
has PubMed association: PMID: 7639698; 7758105; 8069916; 8125298; 8548810; 8565075; 8612133; 8627180; 8643514; 8662842; 8692885; 8702708; 8710854; 8875942; 8943045; 8985011; 8999898; 9020361; 9104814; 9153189; 9162022; 9168896; 9208847; 9244310; 9275204; 9353251; 9384571; 9418902; 9461607; 9464265; 9488716; 9500555; 9582383; 9607925; 9685412; 9692890; 9705938; 9712898; 9718306; 9733516; 9774460; 9774977; 9794406; 9827693; 9852070; 9990007; 10025951; 10037686; 10075662; 10206649; 10339433; 10346818; 10352240; 10411888; 10477597; 10490605; 10514511; 10521462; 10523862; 10544141; 10581243; 10617615; 10650002; 10753917; 10759890; 10764746; 10809768; 10837247; 10880535; 10882101; 10892748; 10903733; 10911999; 10980203; 10990461; 11035039; 11057907; 11064452; 11112773; 11181075; 11278268; 11278723; 11279055; 11340079; 11359906; 11384837; 11435475; 11466612; 11479302; 11562359; 11607847; 11728344; 11777919; 11784851; 11798190; 11804591; 11805080; 11821416; 11882293; 11907088; 11907583; 11909853; 11932422; 11971184; 12005438; 12136106; 12169272; 12220533; 12296995; 12411322; 12411493; 12477932; 12529173; 12547194; 12571250; 12591926; 12637493; 12796506; 12842894; 12843613; 12867425; 12887920; 12917689; 12917690; 12917691; 14517219; 14557256; 14585990; 14633987; 14644197; 14702039; 14741690; 14743216; 14982987; 15084608; 15121867; 15125833; 15208311; 15258597; 15265700; 15308666; 15310755; 15327770; 15383523; 15485634; 15485837; 15489334; 15670770; 15670977; 15696169; 15707590; 15708970; 15743837; 15861135; 15941918; 15944293; 16009713; 16153868; 16189514; 16214042; 16227629; 16260598; 16263936; 16282325; 16291755; 16304992; 16311516; 16341674; 16378096; 16446357; 16603398; 16611992; 16636664; 16713569; 16876162; 16891304; 16936264; 17015619; 17314283; 17379600; 17384642; 17389591; 17544371; 17599408; 17626074; 17724081; 17851586; 17923499; 18022363; 18024283; 18029348; 18069092; 18230756; 18271526; 18292192; 18312353; 18362156; 18362886; 18671942; 18776134; 18787502; 18818748; 18827186; 18950704; …
description: TNF receptor-associated factor 2
database cross reference: Ensembl:ENSG00000127191
database cross reference: HGNC:12032
database cross reference: HPRD:03538
database cross reference: MIM:601895
database cross reference: Vega:OTTHUMG00000020952

TRNAU1
type: Class
subclass of: RNA gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: TRSP
alternative term: tRNA(Sec)
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TRNAU1
full name from nomenclature authority: transfer RNA selenocysteine 1 (anticodon UCA)
NCBI GeneID: 7234
gene map location: 19q13.2-q13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: tRNA
nomenclature status: Official from a nomenclature committee
has PubMed association: PMID: 1395717; 3156131
description: transfer RNA selenocysteine 1 (anticodon UCA)
database cross reference: HGNC:12348
database cross reference: MIM:165060

TST
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: RDS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TST
full name from nomenclature authority: thiosulfate sulfurtransferase (rhodanese)
NCBI GeneID: 7263
NCBI LocusTag: LL22NC01-146D10.3
gene map location: 22q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000096 (EC: TAS); GO_0000098 (EC: TAS); GO_0004792 (EC: IEA); GO_0005615 (EC: IDA); GO_0005739 (EC: IDA); GO_0005743 (EC: IEA); GO_0005759 (EC: TAS); GO_0008097 (EC: IDA); GO_0009440 (EC: TAS, PMID: 9070219); GO_0030855 (EC: IDA); GO_0034641 (EC: TAS); GO_0035928 (EC: IMP); GO_0044281 (EC: TAS); GO_0051029 (EC: IDA); GO_0070221 (EC: TAS)
has PubMed association: PMID: 986188; 1451437; 1691817; 2006499; 2817794; 3178139; 3471602; 3479705; 6402020; 6573305; 6588145; 6928732; 8125298; 8254022; 8340386; 8404072; 9070219; 10591208; 11112515; 11788560; 12477932; 12665801; 12962704; 14702039; 15153070; 15461802; 15489334; 15910006; 16343079; 16500920; 16790311; 17035239; 18029348; 19695240; 20099848; 20663881; 20877624; 21175961; 21685364; 21890473; 21922874; 22939629; 23399736
description: thiosulfate sulfurtransferase (rhodanese)
database cross reference: Ensembl:ENSG00000128311
database cross reference: HGNC:12388
database cross reference: HPRD:01583
database cross reference: MIM:180370
database cross reference: Vega:OTTHUMG00000150533

TUB
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: rd5
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TUB
full name from nomenclature authority: tubby bipartite transcription factor
NCBI GeneID: 7275
gene map location: 11p15.5
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005576 (EC: IEA); GO_0005634 (EC: IEA); GO_0005737 (EC: TAS, PMID: 11000483); GO_0005829 (EC: IEA); GO_0005886 (EC: IEA); GO_0006909 (EC: IEA); GO_0007602 (EC: IEA); GO_0007605 (EC: IEA); GO_0008020 (EC: IEA); GO_0009725 (EC: IEA); GO_0044259 (EC: IEA); GO_0050766 (EC: IDA, PMID: 19837063); GO_0060041 (EC: IEA)
has PubMed association: PMID: 1358794; 8612280; 9096357; 10455176; 10591637; 11000483; 11375483; 11801719; 12477932; 15489334; 16443771; 17498679; 17955208; 18029348; 18183286; 19058789; 19077438; 19486527; 19837063; 19913121; 20080650; 20628086; 20935630; 20978472; 22632162; 23000965
description: tubby bipartite transcription factor
database cross reference: Ensembl:ENSG00000166402
database cross reference: HGNC:12406
database cross reference: HPRD:03121
database cross reference: MIM:601197
database cross reference: Vega:OTTHUMG00000165690

TTR
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CTS
alternative term: CTS1
alternative term: HEL111
alternative term: HsT2651
alternative term: PALB
alternative term: TBPA
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TTR
full name from nomenclature authority: transthyretin
NCBI GeneID: 7276
gene map location: 18q12.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 18
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001523 (EC: TAS); GO_0005179 (EC: IEA); GO_0005515 (EC: IPI, PMID: 16716307); GO_0005576 (EC: NAS, PMID: 14718574); GO_0005576 (EC: TAS); GO_0005615 (EC: IEA); GO_0005737 (EC: IEA); GO_0006810 (EC: IEA); GO_0007603 (EC: TAS); GO_0030198 (EC: TAS); GO_0042562 (EC: IEA); GO_0042572 (EC: IEA); GO_0042802 (EC: IPI, PMID: 19861125); GO_0043234 (EC: IEA); GO_0046982 (EC: IEA)
has PubMed association: PMID: 201845; 574085; 671542; 986177; 1301926; 1351039; 1356051; 1362222; 1436517; 1517749; 1520326; 1520336; 1544214; 1570831; 1602151; 1626570; 1656975; 1666289; 1734866; 1867256; 1877623; 1932142; 1977686; 1979335; 1981182; 1997217; 2015890; 2046936; 2122246; 2161654; 2174830; 2320592; 2360796; 2363717; 2613237; 2693890; 2877582; 2891727; 2990465; 2995367; 3011930; 3022107; 3022108; 3028932; 3135807; 3229002; 3479441; 3675594; 3714052; 3722385; 3760189; 3762958; 3818577; 4044580; 4054629; 4216640; 4328329; 4607556; 4952599; 6087811; 6093805; 6208668; 6300852; 6487335; 6549130; 6583672; 6651852; 7033114; 7417777; 7474944; 7599630; 7754382; 7794243; 7839813; 7850982; 7910950; 7914929; 7923855; 7946531; 8019560; 8038017; 8081397; 8089102; 8095301; 8095302; 8133316; 8218290; 8257997; 8309582; 8352764; 8382610; 8406434; 8428915; 8549676; 8579098; 8692810; 8784093; 8857732; 8960746; 8990019; 9191784; 9307034; 9771673; 9771681; 9789022; 9818054; 9818883; 10052934; 10071047; 10465115; 10529370; 10627135; 10627502; 10671063; 10694917; 10704770; 10742177; 10841549; 10842705; 10845569; 10854215; 10882995; 10982792; 11106758; 11243784; 11418763; 11445644; 11478875; 11577236; 11709003; 11853533; 11913969; 11995997; 12039669; 12082059; 12095258; 12354101; 12403615; 12433265; 12477932; 12481032; 12560553; 12566023; 12593674; 12665801; 12697331; 12771253; 12874414; 12874858; 12876326; 12900507; 13367520; 14506715; 14507924; 14534839; 14578606; 14604984; 14673473; 14690414; 14718574; 14760718; 14981241; 15033978; 15174051; 15210129; 15214015; 15489334; 15536615; 15610856; 15649951; 15736938; 15793844; 15821170; 15930086; 15995833; 16011990; 16053476; 16076613; 16079207; 16114899; 16130282; 16159939; 16169070; 16185074; 16189514; 16194875; 16199891; 16204882; 16219761; 16225852; 16335952; 16386248; 16433699; 16487493; 16552785; 16690497; 16698124; 16716307; 16716350; 16732734; 16751191; 16879610; 16892178; 16893521; 17062384; 17116243; 17143887; 17176092; 17196219; 17203960; 17378…
description: transthyretin
database cross reference: Ensembl:ENSG00000118271
database cross reference: HGNC:12405
database cross reference: HPRD:01447
database cross reference: MIM:176300
database cross reference: Vega:OTTHUMG00000131984

TXN
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: TRDX
alternative term: TRX
alternative term: TRX1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TXN
full name from nomenclature authority: thioredoxin
NCBI GeneID: 7295
NCBI LocusTag: RP11-427L11.1
gene map location: 9q31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11118054); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005737 (EC: IDA); GO_0005739 (EC: IEA); GO_0005829 (EC: TAS); GO_0006351 (EC: IEA); GO_0006662 (EC: IEA); GO_0006928 (EC: TAS, PMID: 10947064); GO_0007165 (EC: TAS, PMID: 10947064); GO_0007267 (EC: TAS, PMID: 10947064); GO_0008283 (EC: TAS, PMID: 3170595); GO_0009314 (EC: IDA, PMID: 11118054); GO_0015035 (EC: IEA); GO_0015037 (EC: IEA); GO_0015949 (EC: TAS); GO_0033158 (EC: IDA, PMID: 11118054); GO_0035872 (EC: TAS); GO_0043388 (EC: IDA, PMID: 11118054); GO_0044281 (EC: TAS); GO_0044822 (EC: IDA); GO_0045087 (EC: TAS); GO_0045454 (EC: IEA); GO_0046826 (EC: IEA); GO_0055086 (EC: TAS); GO_0055114 (EC: IDA, PMID: 11118054); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1874447; 1998498; 2001356; 2176490; 2684271; 2785919; 3170595; 7601465; 7788295; 7821789; 7922028; 8049254; 8736558; 8805557; 9108029; 9369469; 9433926; 9464857; 9564042; 9915858; 10397171; 10419473; 10585464; 10814541; 10843682; 10947064; 10982790; 11012661; 11118054; 11298454; 11323689; 11517226; 11689443; 11751890; 11778846; 11841832; 11972307; 12008049; 12029072; 12089063; 12099690; 12119401; 12189205; 12244106; 12244325; 12477932; 12529245; 12660821; 12804587; 12816947; 12870673; 12878985; 12882768; 14503974; 14644168; 14688353; 14695120; 14703116; 14730345; 15096327; 15128745; 15234975; 15480426; 15489334; 15494431; 15507528; 15694802; 15723974; 15824742; 15894171; 16097034; 16115022; 16207716; 16263712; 16311508; 16424062; 16458196; 16492688; 16507315; 16712525; 16750198; 16766796; 16868544; 16916647; 16966583; 17007870; 17045827; 17113580; 17115890; 17220299; 17316609; 17331951; 17353931; 17360766; 17369362; 17557078; 17574940; 17601350; 17606900; 17634480; 17651689; 17652454; 17724081; 17823364; 17896802; 17917077; 17949784; 17972886; 17982132; 18209488; 18384140; 18420212; 18457020; 18497292; 18544525; 18579387; 18781797; 18835792; 18848838; 18976655; 18977241; 18983687; 19056867; 19120277; 19124506; 19135121; 19208085; 19328186; 19337991; 19385090; 19471022; 19540723; 19558833; 19561639; 19566940; 19592618; 19601712; 19620238; 19671194; 19681600; 19690162; 19723146; 19773351; 19799607; 19913121; 20074557; 20103619; 20172870; 20218863; 20298786; 20347035; 20379614; 20385180; 20423474; 20430109; 20485444; 20536427; 20619274; 20628086; 20661909; 20662007; 20847814; 20877624; 20929309; 20943653; 20955789; 20974843; 21030559; 21139048; 21145461; 21150319; 21158569; 21212402; 21250889; 21319273; 21324905; 21353370; 21526215; 21557999; 21620911; 21636804; 21642987; 21704743; 21705327; 21800051; 21890473; 21906983; 21908620; 21963718; 21988832; 22053931; 22134635; 22248473; 22384152; 22430737; 22447839; 22492997; 22505815; 22516068; 22760822; 22810585; 2286…
description: thioredoxin
database cross reference: Ensembl:ENSG00000136810
database cross reference: HGNC:12435
database cross reference: HPRD:01761
database cross reference: MIM:187700
database cross reference: Vega:OTTHUMG00000020480

TYROBP
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DAP12
alternative term: KARAP
alternative term: PLOSL
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TYROBP
full name from nomenclature authority: TYRO protein tyrosine kinase binding protein
NCBI GeneID: 7305
gene map location: 19q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002281 (EC: IEA); GO_0002283 (EC: IEA); GO_0005057 (EC: TAS, PMID: 9490415); GO_0005102 (EC: IPI, PMID: 15294961); GO_0005515 (EC: IPI, PMID: 10940905); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 9490415); GO_0006968 (EC: TAS, PMID: 9490415); GO_0007165 (EC: TAS, PMID: 9490415); GO_0007229 (EC: IEA); GO_0007411 (EC: TAS); GO_0009986 (EC: IDA, PMID: 15294961); GO_0035556 (EC: TAS, PMID: 9490415); GO_0042802 (EC: IPI); GO_0045087 (EC: TAS); GO_0050776 (EC: TAS); GO_2001204 (EC: IEA)
has PubMed association: PMID: 8889548; 9463329; 9490415; 9655483; 9828133; 9830044; 10049942; 10201920; 10449773; 10604985; 10799849; 10888890; 10940905; 11169398; 11922939; 12080485; 12207350; 12370476; 12426564; 12426565; 12477932; 12569153; 12591902; 12925681; 14707061; 15294961; 15342556; 15356118; 15489334; 15557162; 16206234; 16339517; 16505336; 16715077; 17012248; 17100880; 17125796; 17202323; 17277102; 17301953; 17530208; 19019460; 19075187; 19120482; 19606219; 20212065; 20301376; 20421649; 20628624; 21263069; 21421043; 21841309; 21967868; 22080356; 23561520; 23715743
description: TYRO protein tyrosine kinase binding protein
database cross reference: Ensembl:ENSG00000011600
database cross reference: HGNC:12449
database cross reference: HPRD:04996
database cross reference: MIM:604142
database cross reference: Vega:OTTHUMG00000181739

UBA1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: A1S9
alternative term: A1S9T
alternative term: A1ST
alternative term: AMCX1
alternative term: GXP1
alternative term: POC20
alternative term: SMAX2
alternative term: UBA1A
alternative term: UBE1
alternative term: UBE1X
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: UBA1
full name from nomenclature authority: ubiquitin-like modifier activating enzyme 1
NCBI GeneID: 7317
NCBI LocusTag: CTD-2522E6.1
gene map location: Xp11.23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 16227972); GO_0005524 (EC: IEA); GO_0008219 (EC: IEA); GO_0008641 (EC: IEA); GO_0016567 (EC: IEA); GO_0016874 (EC: IEA); GO_0044822 (EC: IDA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 1544321; 1606621; 1845793; 1871145; 1986373; 2265617; 2323223; 2390975; 3390177; 7673335; 7724583; 8051045; 8550581; 8573590; 8663123; 9467000; 9644242; 11447495; 11846513; 12477932; 12883554; 12938929; 14702039; 14733918; 15202508; 15247261; 15302935; 15489334; 15576338; 15592455; 15852347; 16169070; 16196087; 16227972; 16263121; 16595681; 16712842; 16713569; 16964243; 17060614; 17580310; 17597759; 17686993; 17956732; 17980597; 18029348; 18179898; 18661401; 18678647; 18781797; 19019082; 19056867; 19135240; 19471022; 19723899; 19850743; 20004025; 20301739; 20360068; 20639865; 20653130; 21081666; 21139048; 21145461; 21252943; 21319273; 21890473; 21900206; 21906983; 21963094; 21987572; 21988832; 22053931; 22069333; 22145905; 22190034; 22279528; 22350887; 22370482; 22427669; 22434192; 22456334; 22505724; 22797925; 22863883; 22939629; 22999844; 23000965; 23003343; 23349634; 23524849; 23801757; 23824909; 23862649
description: ubiquitin-like modifier activating enzyme 1
database cross reference: Ensembl:ENSG00000130985
database cross reference: HGNC:12469
database cross reference: HPRD:02440
database cross reference: MIM:314370
database cross reference: Vega:OTTHUMG00000021436

UBP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LBP-1B
alternative term: LBP-1a
alternative term: LBP1A
alternative term: LBP1B
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: UBP1
full name from nomenclature authority: upstream binding protein 1 (LBP-1a)
NCBI GeneID: 7342
gene map location: 3p22.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001525 (EC: IEA); GO_0003677 (EC: IEA); GO_0003700 (EC: TAS, PMID: 8114710); GO_0003714 (EC: TAS, PMID: 8114710); GO_0005634 (EC: TAS, PMID: 8114710); GO_0006351 (EC: IEA); GO_0006357 (EC: TAS, PMID: 8114710); GO_0019079 (EC: TAS, PMID: 8114710); GO_0045892 (EC: TAS, PMID: 8114710)
has PubMed association: PMID: 2006421; 7836461; 8114710; 10644752; 12477932; 14702039; 15207707; 15471945; 15489334; 16344560; 18004979; 19322201; 19471022; 19505873; 19662162; 19751393; 20211142; 21956701; 21988832; 22939629
description: upstream binding protein 1 (LBP-1a)
database cross reference: Ensembl:ENSG00000153560
database cross reference: HGNC:12507
database cross reference: HPRD:10291
database cross reference: MIM:609784
database cross reference: Vega:OTTHUMG00000130749

VCAM1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD106
alternative term: INCAM-100
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: VCAM1
full name from nomenclature authority: vascular cell adhesion molecule 1
NCBI GeneID: 7412
gene map location: 1p32-p31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001666 (EC: IEA); GO_0002102 (EC: IDA, PMID: 15220135); GO_0002526 (EC: IEA); GO_0002544 (EC: IEA); GO_0005178 (EC: IDA, PMID: 1377228); GO_0005178 (EC: IMP, PMID: 19738201); GO_0005615 (EC: IDA, PMID: 9290466); GO_0005769 (EC: IDA); GO_0005783 (EC: IDA); GO_0005794 (EC: IDA); GO_0005886 (EC: TAS); GO_0005902 (EC: IDA, PMID: 12082081); GO_0007155 (EC: IDA, PMID: 16809613); GO_0007157 (EC: IDA, PMID: 1715889); GO_0007159 (EC: IDA, PMID: 1381355); GO_0007507 (EC: IEA); GO_0007568 (EC: IEA); GO_0007584 (EC: IEA); GO_0008131 (EC: IDA); GO_0009308 (EC: IDA); GO_0009897 (EC: IDA, PMID: 1377228); GO_0009986 (EC: IDA, PMID: 1715889); GO_0010043 (EC: IEA); GO_0010212 (EC: IEA); GO_0016021 (EC: IEA); GO_0016032 (EC: IEA); GO_0019221 (EC: TAS); GO_0022614 (EC: IEP, PMID: 12082081); GO_0030175 (EC: IDA, PMID: 12082081); GO_0030183 (EC: IC, PMID: 1715889); GO_0030198 (EC: TAS); GO_0032496 (EC: IEA); GO_0035094 (EC: IEA); GO_0035924 (EC: IEA); GO_0042102 (EC: IDA, PMID: 1381355); GO_0042383 (EC: IEA); GO_0045177 (EC: IDA, PMID: 12082081); GO_0045471 (EC: IEA); GO_0050776 (EC: TAS); GO_0050839 (EC: IDA, PMID: 1377228); GO_0050839 (EC: IPI, PMID: 12082081); GO_0050901 (EC: IEP, PMID: 2688898); GO_0055114 (EC: IDA); GO_0060326 (EC: IEA); GO_0060333 (EC: TAS); GO_0060710 (EC: IEA); GO_0071065 (EC: IDA, PMID: 15220135); GO_0071333 (EC: IEA); GO_0071356 (EC: IEA)
has PubMed association: PMID: 1281211; 1377228; 1379595; 1381355; 1699207; 1707234; 1707873; 1713772; 1715583; 1715889; 2688898; 7521694; 7531291; 7534402; 7539925; 7545397; 7691867; 7884872; 8125298; 8607877; 8825878; 8977311; 9117345; 9184636; 9269771; 9290466; 9443894; 9603478; 9792375; 9973426; 10209034; 10377075; 10438935; 10477700; 10556825; 10602408; 10623819; 10944555; 11123288; 11517385; 11520773; 11776680; 11817523; 11847011; 11882338; 11904449; 11922919; 11929779; 11935152; 11961404; 11963839; 11983205; 12006387; 12082081; 12086338; 12097820; 12105209; 12115600; 12172318; 12172576; 12193695; 12351381; 12387879; 12393616; 12433638; 12477932; 12493764; 12587980; 12601490; 12643440; 12650924; 12673844; 12682249; 12700137; 12704784; 12714597; 12759453; 12788528; 12871600; 12940514; 12958610; 12969778; 14534081; 14550782; 14592496; 14615367; 14684616; 14691297; 14741380; 14748068; 14762656; 14984317; 15009098; 15059493; 15078922; 15080580; 15116247; 15175347; 15194470; 15220135; 15225366; 15265790; 15299708; 15304054; 15308572; 15340161; 15489334; 15489374; 15489375; 15525877; 15548573; 15661077; 15661918; 15666579; 15710215; 15784173; 15805138; 15806475; 15845907; 15979542; 16002075; 16015337; 16127297; 16184405; 16230423; 16242117; 16317091; 16327982; 16335952; 16344560; 16498082; 16585601; 16644735; 16722038; 16790997; 16809613; 16874958; 16902065; 16914554; 16977262; 16987074; 17008592; 17022986; 17090406; 17115186; 17116732; 17126824; 17142773; 17167725; 17192354; 17255534; 17258924; 17292586; 17303384; 17334226; 17352405; 17430469; 17431880; 17437524; 17497038; 17517105; 17521609; 17530710; 17531998; 17560459; 17564956; 17586618; 17597073; 17599409; 17616653; 17657162; 17678915; 17702963; 17703412; 17706337; 17706953; 17714716; 17891599; 17906965; 17922685; 17943642; 17962718; 17963163; 17964973; 17983593; 18078450; 18160848; 18197885; 18212564; 18227515; 18284603; 18326231; 18383329; 18406566; 18420209; 18421029; 18449421; 18462748; 18473733; 18482273; 18490752; 18504269; 1855…
description: vascular cell adhesion molecule 1
database cross reference: Ensembl:ENSG00000162692
database cross reference: HGNC:12663
database cross reference: HPRD:01888
database cross reference: MIM:192225
database cross reference: Vega:OTTHUMG00000010982

VEGFA
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MVCD1
alternative term: VEGF
alternative term: VPF
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: VEGFA
full name from nomenclature authority: vascular endothelial growth factor A
NCBI GeneID: 7422
NCBI LocusTag: RP1-261G23.1
gene map location: 6p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IDA, PMID: 18093989); GO_0001525 (EC: IDA, PMID: 11427521); GO_0001541 (EC: ISS); GO_0001569 (EC: ISS); GO_0001570 (EC: TAS, PMID: 15015550); GO_0001666 (EC: IDA, PMID: 16490744); GO_0001701 (EC: ISS); GO_0001822 (EC: ISS); GO_0001934 (EC: IDA, PMID: 18386220); GO_0001938 (EC: IDA, PMID: 10022831); GO_0001938 (EC: ISS); GO_0001968 (EC: IDA, PMID: 14570917); GO_0002042 (EC: IDA, PMID: 18059339); GO_0002052 (EC: ISS); GO_0002053 (EC: ISS); GO_0002092 (EC: IDA); GO_0002575 (EC: IDA, PMID: 17082651); GO_0002576 (EC: TAS); GO_0002687 (EC: TAS, PMID: 1312256); GO_0003007 (EC: ISS); GO_0003151 (EC: ISS); GO_0003169 (EC: ISS); GO_0005125 (EC: IDA, PMID: 18440775); GO_0005125 (EC: ISS); GO_0005161 (EC: IPI, PMID: 17470632); GO_0005172 (EC: IPI, PMID: 10471394); GO_0005515 (EC: IPI, PMID: 10543948); GO_0005576 (EC: TAS); GO_0005578 (EC: NAS, PMID: 14570917); GO_0005615 (EC: IDA, PMID: 16490744); GO_0005615 (EC: ISS); GO_0005737 (EC: IDA, PMID: 17082651); GO_0006357 (EC: IMP, PMID: 18093989); GO_0007399 (EC: TAS, PMID: 15351965); GO_0007498 (EC: ISS); GO_0007595 (EC: ISS); GO_0007596 (EC: TAS); GO_0008083 (EC: IDA); GO_0008083 (EC: ISS); GO_0008201 (EC: IDA, PMID: 15001987); GO_0008201 (EC: IMP, PMID: 14570917); GO_0008284 (EC: IDA, PMID: 7929439); GO_0008360 (EC: IDA, PMID: 10527820); GO_0009986 (EC: IDA, PMID: 17470632); GO_0010595 (EC: IDA, PMID: 10022831); GO_0010628 (EC: IDA, PMID: 18386220); GO_0016020 (EC: IEA); GO_0030141 (EC: IDA, PMID: 17082651); GO_0030168 (EC: TAS); GO_0030224 (EC: IDA); GO_0030225 (EC: IDA); GO_0030324 (EC: ISS); GO_0030335 (EC: IDA, PMID: 17470632); GO_0030855 (EC: ISS); GO_0030949 (EC: IDA, PMID: 1312256); GO_0031077 (EC: ISS); GO_0031093 (EC: TAS); GO_0031334 (EC: IDA, PMID: 16489009); GO_0031954 (EC: IDA, PMID: 17470632); GO_0032147 (EC: IDA, PMID: 18059339); GO_0032793 (EC: IDA); GO_0033138 (EC: IDA, PMID: 18440775); GO_0035148 (EC: IDA, PMID: 19033661); GO_0035767 (EC: IDA, PMID: 18440775); GO_0035924 (EC: IDA, PMID: 18440775…
has PubMed association: PMID: 1312256; 1417831; 1550962; 1567395; 1711045; 1791831; 2479986; 2479987; 2584205; 7518352; 7525053; 7678805; 7681362; 7759509; 7829517; 7929439; 8621427; 8631822; 8641698; 8702615; 8786112; 8889548; 9012504; 9012841; 9054410; 9202027; 9207067; 9323936; 9336848; 9351807; 9393862; 9450968; 9529250; 9634701; 9674707; 9684805; 9716565; 9792673; 9878851; 9922142; 10022831; 10066377; 10067980; 10196157; 10409677; 10464055; 10471394; 10527820; 10543948; 10575000; 10585578; 10626738; 10748121; 10873597; 11016853; 11032698; 11069235; 11115828; 11122379; 11133233; 11146397; 11196464; 11352659; 11427521; 11461089; 11563986; 11642726; 11686329; 11705851; 11705867; 11731620; 11741977; 11742492; 11744618; 11748975; 11751905; 11783119; 11784713; 11784722; 11796824; 11806247; 11809675; 11809713; 11815711; 11819817; 11824377; 11831981; 11832343; 11834731; 11836562; 11839635; 11847008; 11866530; 11866538; 11867956; 11875709; 11877311; 11877669; 11882460; 11891801; 11908876; 11912213; 11912219; 11920479; 11921018; 11930687; 11930688; 11940485; 11956584; 11956638; 11957147; 11959648; 11960372; 11961297; 11961303; 11964077; 11964307; 11972026; 11978184; 11978667; 11980898; 11986311; 11986954; 11999550; 12012273; 12014632; 12016145; 12023772; 12038454; 12039075; 12042276; 12058259; 12062186; 12067896; 12067976; 12085210; 12086892; 12089333; 12102661; 12105188; 12114504; 12117969; 12119553; 12124351; 12127077; 12133473; 12133520; 12133521; 12141529; 12149254; 12151344; 12151391; 12163680; 12168088; 12168808; 12168898; 12174362; 12174901; 12187074; 12197476; 12207021; 12208766; 12209585; 12209725; 12213806; 12213874; 12213878; 12215337; 12232762; 12235106; 12239588; 12358602; 12391145; 12391545; 12393542; 12400015; 12406876; 12407018; 12413884; 12425822; 12427739; 12427750; 12428103; 12429966; 12430738; 12439912; 12445161; 12446667; 12451991; 12452000; 12453880; 12453985; 12456629; 12474525; 12477932; 12481883; 12482858; 12482957; 12493399; 12496364; 12499259; 12505748; 12509426; 1250…
description: vascular endothelial growth factor A
database cross reference: Ensembl:ENSG00000112715
database cross reference: HGNC:12680
database cross reference: HPRD:01889
database cross reference: MIM:192240
database cross reference: Vega:OTTHUMG00000014745

VHL
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HRCA1
alternative term: RCA1
alternative term: VHL1
alternative term: pVHL
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: VHL
full name from nomenclature authority: von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
NCBI GeneID: 7428
gene map location: 3p25.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: TAS, PMID: 7660122); GO_0000902 (EC: NAS, PMID: 12169691); GO_0004842 (EC: TAS); GO_0005515 (EC: IPI, PMID: 11641274); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005739 (EC: NAS, PMID: 12169691); GO_0005783 (EC: NAS, PMID: 12169691); GO_0005829 (EC: TAS); GO_0006355 (EC: IMP, PMID: 15824735); GO_0006508 (EC: TAS, PMID: 10353251); GO_0006950 (EC: NAS, PMID: 12169691); GO_0008134 (EC: IPI, PMID: 11641274); GO_0008285 (EC: TAS, PMID: 7660130); GO_0016020 (EC: IEA); GO_0016567 (EC: IMP, PMID: 12169691); GO_0019899 (EC: IPI, PMID: 11641274); GO_0043066 (EC: NAS, PMID: 12169691); GO_0045111 (EC: IDA); GO_0045597 (EC: NAS, PMID: 12169691); GO_0045893 (EC: IMP, PMID: 17973242); GO_0050821 (EC: NAS, PMID: 12169691); GO_0061418 (EC: TAS); GO_0061428 (EC: IDA, PMID: 11641274); GO_0071456 (EC: TAS)
has PubMed association: PMID: 1673491; 7563486; 7566098; 7604013; 7660122; 7660130; 7690964; 7728151; 7759077; 7829101; 7987306; 7987327; 8069849; 8183553; 8270255; 8493574; 8522307; 8550742; 8592333; 8634692; 8674032; 8700833; 8730290; 8733131; 8765323; 8825918; 8863170; 8931697; 8956040; 9122164; 9156047; 9271438; 9341197; 9399847; 9447969; 9651579; 9663592; 9671762; 9751722; 9829911; 9829912; 9880225; 10205047; 10318914; 10353251; 10364675; 10408776; 10421634; 10449727; 10491320; 10523847; 10533030; 10535940; 10587522; 10627136; 10635329; 10823831; 10850420; 10878807; 10944113; 10973499; 11024059; 11226425; 11292861; 11292862; 11331613; 11358837; 11384984; 11483638; 11504942; 11517223; 11545595; 11566883; 11574546; 11641274; 11709017; 11739384; 11749004; 11779168; 11840338; 11865071; 11865075; 11908068; 11921283; 11986208; 11987242; 11990703; 12000816; 12004076; 12016154; 12032852; 12036906; 12048197; 12050673; 12056827; 12086860; 12086861; 12097293; 12114475; 12114495; 12169691; 12205091; 12209156; 12351678; 12374282; 12378530; 12393546; 12414898; 12415268; 12460920; 12464182; 12468553; 12477932; 12482756; 12490973; 12510195; 12511881; 12538644; 12586829; 12604794; 12606543; 12609565; 12640117; 12644949; 12673678; 12682018; 12682336; 12684640; 12692265; 12697815; 12743597; 12767066; 12781449; 12808024; 12810083; 12821933; 12839965; 12844285; 12912922; 12925778; 12937142; 13679920; 13985160; 14506252; 14517280; 14531799; 14556007; 14600153; 14604959; 14636579; 14667507; 14691445; 14691554; 14722919; 14726398; 14729622; 14767570; 14963040; 14973063; 14985465; 15060148; 15082527; 15084514; 15122713; 15162797; 15231748; 15300849; 15448019; 15467305; 15530850; 15572213; 15601820; 15604095; 15607616; 15608669; 15611064; 15696489; 15721254; 15750626; 15777842; 15805242; 15809750; 15824109; 15824735; 15849821; 15893810; 15921386; 15932632; 15935760; 15962286; 15966899; 15985433; 15998523; 16107702; 16140212; 16142346; 16144691; 16170373; 16208141; 16210343; 16234850; 16261165; 16278378; 163146…
description: von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
database cross reference: HGNC:12687
database cross reference: HPRD:01905
database cross reference: MIM:608537

VLDLR
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CARMQ1
alternative term: CHRMQ1
alternative term: VLDLRCH
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: VLDLR
full name from nomenclature authority: very low density lipoprotein receptor
NCBI GeneID: 7436
NCBI LocusTag: RP11-320E16.1
gene map location: 9p24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: ISS); GO_0001948 (EC: IPI, PMID: 10571240); GO_0005041 (EC: TAS, PMID: 10380922); GO_0005509 (EC: IEA); GO_0005515 (EC: IPI, PMID: 8083232); GO_0005886 (EC: TAS, PMID: 10380922); GO_0005905 (EC: IEA); GO_0006869 (EC: IEA); GO_0006898 (EC: IDA, PMID: 10571240); GO_0007165 (EC: TAS, PMID: 10380922); GO_0007399 (EC: TAS, PMID: 10380922); GO_0007613 (EC: TAS, PMID: 7550352); GO_0008203 (EC: IEA); GO_0016020 (EC: IDA, PMID: 15082773); GO_0016021 (EC: IEA); GO_0021517 (EC: IEA); GO_0030229 (EC: IDA, PMID: 8083232); GO_0034185 (EC: IDA, PMID: 10571240); GO_0034185 (EC: ISS); GO_0034189 (EC: IDA, PMID: 10571240); GO_0034361 (EC: IEA); GO_0034436 (EC: IDA, PMID: 10571240); GO_0034437 (EC: IDA, PMID: 10571240); GO_0034447 (EC: IDA, PMID: 8083232); GO_0038025 (EC: ISS); GO_0038026 (EC: ISS); GO_0043235 (EC: IDA); GO_0045860 (EC: IEA); GO_0048306 (EC: IPI, PMID: 10571240); GO_1900006 (EC: ISS)
has PubMed association: PMID: 7550352; 7592875; 7797576; 7828550; 8020981; 8069294; 8083232; 8128315; 8294473; 9132912; 9555943; 9630508; 10380922; 10391209; 10571240; 10571241; 10629142; 10827173; 11266465; 11342683; 11931574; 12167620; 12169628; 12363388; 12477932; 12670700; 12824284; 12857919; 12899622; 14702039; 15064754; 15082773; 15164053; 15863833; 15950758; 15950998; 15953542; 16080122; 16384981; 17330141; 17472347; 17854420; 17890782; 17936586; 18032585; 18039658; 18043714; 18056683; 18277139; 18326629; 18364738; 18685438; 19015224; 19224153; 19393635; 19913121; 20301729; 20427281; 20624392; 20628086; 21047397; 21063833; 21601501; 21642441; 21734303; 21757650; 21890473; 21963094; 21987572; 22005931; 22109552; 22170052; 22189190; 22355348; 22419519; 22532556; 22780124; 22876580; 22973972; 23000965; 23185271; 23670308; 23701949; 23811271
description: very low density lipoprotein receptor
relation: Alzpathway: VLDLR-APOE association. Source: https://pubmed.ncbi.nlm.nih.gov/28292942/
database cross reference: Ensembl:ENSG00000147852
database cross reference: HGNC:12698
database cross reference: HPRD:01895
database cross reference: MIM:192977
database cross reference: Vega:OTTHUMG00000019447

WNT1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BMND16
alternative term: INT1
alternative term: OI15
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: WNT1
full name from nomenclature authority: wingless-type MMTV integration site family, member 1
NCBI GeneID: 7471
gene map location: 12q13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000578 (EC: ISS); GO_0001658 (EC: IEA); GO_0001934 (EC: IEA); GO_0005109 (EC: IBA); GO_0005109 (EC: IC, PMID: 19756656); GO_0005125 (EC: ISS); GO_0005576 (EC: TAS); GO_0005578 (EC: IEA); GO_0005615 (EC: IBA); GO_0005737 (EC: IDA, PMID: 11793365); GO_0005788 (EC: TAS); GO_0005796 (EC: TAS); GO_0005886 (EC: TAS); GO_0007267 (EC: ISS); GO_0007520 (EC: IEA); GO_0008284 (EC: IDA, PMID: 16501043); GO_0008284 (EC: IMP, PMID: 19778454); GO_0009611 (EC: IEP, PMID: 17982423); GO_0009986 (EC: IEA); GO_0010592 (EC: IMP, PMID: 19756656); GO_0010812 (EC: IDA, PMID: 16501043); GO_0016055 (EC: IDA, PMID: 10644691); GO_0019904 (EC: IEA); GO_0021527 (EC: IEA); GO_0021536 (EC: IEA); GO_0021551 (EC: ISS); GO_0021588 (EC: ISS); GO_0021797 (EC: IEA); GO_0022004 (EC: IEA); GO_0022408 (EC: IMP, PMID: 17072303); GO_0030182 (EC: IBA); GO_0030512 (EC: IEA); GO_0030514 (EC: IMP, PMID: 16194878); GO_0030579 (EC: IEA); GO_0030901 (EC: ISS); GO_0031100 (EC: IEA); GO_0033077 (EC: IEA); GO_0042472 (EC: IEA); GO_0042770 (EC: IDA, PMID: 16501043); GO_0043568 (EC: IDA, PMID: 12154096); GO_0044212 (EC: IDA, PMID: 19847889); GO_0044336 (EC: IMP, PMID: 12154096); GO_0045165 (EC: IBA); GO_0045599 (EC: ISS); GO_0045747 (EC: IDA, PMID: 16501043); GO_0045893 (EC: IDA, PMID: 10644691); GO_0045893 (EC: IMP, PMID: 19847889); GO_0045893 (EC: ISS); GO_0045944 (EC: IEA); GO_0048018 (EC: IC, PMID: 19778454); GO_0048146 (EC: IMP, PMID: 19734317); GO_0048664 (EC: IEA); GO_0051091 (EC: ISS); GO_0060061 (EC: ISS); GO_0060070 (EC: IMP, PMID: 19756656); GO_0060348 (EC: IMP); GO_0061184 (EC: IDA, PMID: 10654605); GO_0070365 (EC: IEA); GO_0071375 (EC: IEA); GO_0071425 (EC: IEA); GO_0090344 (EC: IDA, PMID: 16501043); GO_2000059 (EC: IEA)
has PubMed association: PMID: 2202907; 2534596; 2998762; 3281802; 3329717; 9147651; 10347172; 10511339; 10557084; 10644691; 10654605; 10866835; 11029007; 11336703; 11350055; 11448771; 11782388; 11793365; 11832495; 12014624; 12154096; 12209999; 12477932; 14644163; 14960582; 15149841; 15194563; 15454084; 15489334; 15580286; 15592430; 15824740; 15841445; 15913453; 16194878; 16329837; 16427602; 16474850; 16495219; 16501043; 16565090; 16756720; 16760136; 16930536; 17035233; 17072303; 17143299; 17289346; 17306035; 17875805; 17947472; 17982423; 18056036; 18059186; 18097596; 18187620; 18218837; 18297060; 18461473; 18469861; 18562274; 18593917; 18636547; 18676739; 18705344; 18762249; 18769115; 18769117; 18790633; 18824543; 18838960; 18844223; 18936100; 19061838; 19148501; 19174556; 19349579; 19398721; 19401692; 19448422; 19453261; 19473496; 19628668; 19693690; 19711366; 19729480; 19734317; 19756656; 19778454; 19781444; 19847889; 19885602; 19924227; 19956716; 19956832; 20334650; 20491588; 20564229; 20664938; 20809334; 20865400; 21044957; 21259057; 21317455; 21321190; 21336184; 21344486; 21505183; 21678109; 21680704; 21781302; 21851818; 21858154; 21971039; 22117039; 22123293; 22139084; 22270359; 22351518; 22388478; 22391424; 22392999; 22406377; 22494971; 22546285; 22696217; 22815884; 22823957; 22859293; 22954590; 23134367; 23152495; 23284750; 23379509; 23434763; 23499309; 23499310; 23551536; 23613467; 23656646; 23851184; 23913826; 24067880; 24305876; 24374807
description: wingless-type MMTV integration site family, member 1
database cross reference: HGNC:12774
database cross reference: HPRD:01276
database cross reference: MIM:164820

WNT5A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: hWNT5A
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: WNT5A
full name from nomenclature authority: wingless-type MMTV integration site family, member 5A
NCBI GeneID: 7474
gene map location: 3p21-p14
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: IDA); GO_0001667 (EC: IEA); GO_0001736 (EC: IEA); GO_0001756 (EC: IEA); GO_0001837 (EC: IEP, PMID: 12841867); GO_0001843 (EC: IEA); GO_0001938 (EC: IMP, PMID: 17986384); GO_0001947 (EC: IEA); GO_0002053 (EC: IEA); GO_0002088 (EC: ISS, PMID: 16258938); GO_0002741 (EC: IMP, PMID: 18174455); GO_0003323 (EC: IEA); GO_0003408 (EC: ISS, PMID: 16258938); GO_0003700 (EC: IMP, PMID: 19847889); GO_0005109 (EC: IPI, PMID: 18174455); GO_0005110 (EC: IEA); GO_0005115 (EC: IPI, PMID: 18287027); GO_0005125 (EC: IEA); GO_0005576 (EC: TAS); GO_0005578 (EC: IEA); GO_0005615 (EC: IDA, PMID: 18703641); GO_0005788 (EC: TAS); GO_0005796 (EC: TAS); GO_0005886 (EC: TAS); GO_0006468 (EC: IEA); GO_0007223 (EC: IDA, PMID: 19946729); GO_0007223 (EC: IMP, PMID: 17986384); GO_0007257 (EC: IDA); GO_0007257 (EC: IMP); GO_0007411 (EC: ISS); GO_0007442 (EC: IEA); GO_0007494 (EC: IEA); GO_0008584 (EC: IEP, PMID: 17848411); GO_0008595 (EC: IEA); GO_0009986 (EC: IEA); GO_0010033 (EC: IEP, PMID: 17486081); GO_0010595 (EC: IMP, PMID: 17035633); GO_0010800 (EC: IEA); GO_0010820 (EC: IMP, PMID: 19520808); GO_0010976 (EC: ISS); GO_0016055 (EC: IDA); GO_0019904 (EC: IEA); GO_0021891 (EC: ISS); GO_0030182 (EC: IBA); GO_0030182 (EC: ISS); GO_0030216 (EC: IEP, PMID: 19399181); GO_0030324 (EC: IEA); GO_0030514 (EC: IEA); GO_0030669 (EC: TAS); GO_0030825 (EC: IDA, PMID: 19946729); GO_0032148 (EC: IDA); GO_0032729 (EC: IEA); GO_0032755 (EC: IMP, PMID: 18174455); GO_0033138 (EC: IEA); GO_0034613 (EC: IDA, PMID: 19177143); GO_0036342 (EC: IEA); GO_0038031 (EC: IEA); GO_0040037 (EC: IEA); GO_0042060 (EC: IDA, PMID: 19878652); GO_0042733 (EC: IEA); GO_0043032 (EC: IMP, PMID: 18174455); GO_0043066 (EC: IDA, PMID: 19251946); GO_0044212 (EC: IDA, PMID: 19847889); GO_0045080 (EC: IMP, PMID: 19520808); GO_0045165 (EC: IBA); GO_0045599 (EC: IMP); GO_0045732 (EC: IGI, PMID: 12952940); GO_0045766 (EC: IMP, PMID: 17035633); GO_0045778 (EC: IMP); GO_0045836 (EC: IEA); GO_0045892 (EC: IDA, PMID: 19277043); GO_004…
has PubMed association: PMID: 8167409; 8288227; 8537388; 8889548; 9054360; 9787155; 10491302; 10557084; 11956659; 12086864; 12165812; 12244165; 12477932; 12482967; 12805222; 12839624; 12841867; 12952940; 14702039; 15040835; 15067324; 15389636; 15588944; 15592517; 15735754; 16169547; 16258938; 16344560; 16569699; 16601243; 16880514; 16914445; 16996564; 17035633; 17227781; 17426020; 17458904; 17463182; 17486081; 17525119; 17546602; 17709179; 17848411; 17937436; 17952396; 17956663; 17967789; 17976063; 17986384; 17992121; 18032022; 18172252; 18174174; 18174455; 18287027; 18413325; 18420933; 18456733; 18462958; 18477650; 18541964; 18615587; 18632632; 18656562; 18703641; 18794093; 18990694; 19048125; 19061910; 19063862; 19074888; 19099253; 19148501; 19171330; 19177143; 19244247; 19251946; 19277043; 19399181; 19453261; 19467340; 19473452; 19492056; 19520808; 19561643; 19582886; 19651774; 19696445; 19760930; 19802008; 19847889; 19849855; 19874313; 19878652; 19910923; 19918918; 19940551; 19946729; 19956879; 20008136; 20032469; 20083703; 20101234; 20376066; 20379614; 20429785; 20454608; 20518933; 20525402; 20554957; 20603606; 20628624; 20634891; 20639201; 20890934; 20955350; 21069266; 21115903; 21165581; 21205070; 21209903; 21270611; 21285942; 21342370; 21344486; 21352264; 21365928; 21431850; 21461571; 21587258; 21672426; 21816908; 21871017; 21918189; 21963094; 21980498; 22039506; 22101459; 22124122; 22128168; 22162112; 22293903; 22384081; 22384249; 22485170; 22493546; 22547701; 22609948; 22655072; 22694338; 22781592; 22825874; 23001722; 23046419; 23054609; 23075330; 23159080; 23178630; 23254341; 23265959; 23266365; 23271023; 23278988; 23342259; 23349696; 23353182; 23359789; 23396967; 23417837; 23462101; 23469623; 23484019; 23615002; 23660959; 23679576; 23716599; 23764752; 23963164; 24091015; 24250222
description: wingless-type MMTV integration site family, member 5A
database cross reference: Ensembl:ENSG00000114251
database cross reference: HGNC:12784
database cross reference: HPRD:01293
database cross reference: MIM:164975
database cross reference: Vega:OTTHUMG00000158361

WNT7A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: WNT7A
full name from nomenclature authority: wingless-type MMTV integration site family, member 7A
NCBI GeneID: 7476
gene map location: 3p25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000578 (EC: IMP, PMID: 16826533); GO_0001502 (EC: IDA, PMID: 17202865); GO_0002062 (EC: IDA, PMID: 17202865); GO_0005102 (EC: IPI, PMID: 12857724); GO_0005109 (EC: IBA); GO_0005125 (EC: IDA, PMID: 18986540); GO_0005576 (EC: TAS); GO_0005578 (EC: IEA); GO_0005615 (EC: IBA); GO_0005788 (EC: TAS); GO_0005796 (EC: TAS); GO_0005886 (EC: TAS); GO_0007269 (EC: IEA); GO_0007548 (EC: TAS, PMID: 9790192); GO_0008105 (EC: IEA); GO_0009953 (EC: IEA); GO_0009986 (EC: IEA); GO_0014719 (EC: IEA); GO_0014834 (EC: IEA); GO_0021707 (EC: IEA); GO_0021846 (EC: IDA, PMID: 12843296); GO_0022009 (EC: IEA); GO_0030010 (EC: IEA); GO_0030182 (EC: IBA); GO_0031133 (EC: IEA); GO_0032355 (EC: IEA); GO_0035115 (EC: IMP, PMID: 16826533); GO_0035116 (EC: IMP, PMID: 16826533); GO_0035567 (EC: IEA); GO_0035659 (EC: IDA, PMID: 15802269); GO_0042733 (EC: IMP, PMID: 16826533); GO_0043066 (EC: IEA); GO_0045165 (EC: IBA); GO_0045893 (EC: IDA, PMID: 15802269); GO_0045944 (EC: IDA, PMID: 12857724); GO_0046330 (EC: IBA); GO_0048018 (EC: IC, PMID: 15802269); GO_0048018 (EC: IDA, PMID: 18986540); GO_0048103 (EC: IEA); GO_0048864 (EC: IDA, PMID: 12843296); GO_0050768 (EC: IDA, PMID: 12843296); GO_0050808 (EC: IEA); GO_0051965 (EC: IDA, PMID: 18986540); GO_0060021 (EC: IMP, PMID: 18413325); GO_0060054 (EC: IDA, PMID: 15802269); GO_0060066 (EC: IEA); GO_0060070 (EC: IDA, PMID: 12857724); GO_0061038 (EC: IEA); GO_0070307 (EC: ISS, PMID: 16258938); GO_0071560 (EC: IEP, PMID: 15040835); GO_0090263 (EC: IEA)
has PubMed association: PMID: 8167409; 8168088; 8893824; 9161407; 9790192; 11070089; 11232041; 11784006; 12477932; 12843296; 12857724; 12893825; 12937339; 14550385; 15040835; 15082716; 15705594; 15802269; 16169070; 16258938; 16826533; 16835228; 17201809; 17202865; 17588571; 18230341; 18413325; 18538017; 18606951; 18986540; 19054571; 19159115; 19171330; 19453261; 19849868; 20083228; 20219685; 20379614; 20470940; 20501643; 20503388; 20709709; 20845993; 20949531; 21271649; 21344627; 22177312; 22232518; 22294752; 22403725; 22987443; 23056560; 23144326; 23321718; 23727605
description: wingless-type MMTV integration site family, member 7A

XBP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: TREB5
alternative term: XBP-1
alternative term: XBP2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: XBP1
full name from nomenclature authority: X-box binding protein 1
NCBI GeneID: 7494
gene map location: 22q12.1|22q12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003677 (EC: TAS, PMID: 1718857); GO_0003700 (EC: IEA); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0006366 (EC: IEA); GO_0006955 (EC: TAS, PMID: 1718857); GO_0006987 (EC: TAS); GO_0030968 (EC: TAS); GO_0031017 (EC: IEA); GO_0042493 (EC: IEA); GO_0043565 (EC: IEA); GO_0044267 (EC: TAS); GO_0051602 (EC: IEA); GO_0060096 (EC: IEA); GO_0060691 (EC: IEA); GO_0071236 (EC: IEA); GO_1900103 (EC: IMP, PMID: 16645094)
has PubMed association: PMID: 1718857; 1903538; 2196176; 2321018; 8349596; 8657566; 9563853; 10591208; 10652269; 11076863; 11256614; 11779464; 11813207; 12067985; 12477932; 12586069; 12713871; 12805554; 12949534; 12954762; 14576841; 14634507; 14702039; 15063770; 15149721; 15184063; 15298659; 15331160; 15351732; 15380296; 15461802; 15489334; 15489336; 15598891; 15882996; 15892135; 15927087; 15936534; 16002735; 16009131; 16154272; 16342282; 16381901; 16461360; 16645094; 16958950; 17026957; 17034899; 17092596; 17418411; 17442311; 17660348; 17884689; 17898050; 17906960; 17928342; 17932454; 18082745; 18191223; 18192112; 18386815; 18417469; 18552212; 18583979; 18635891; 18676680; 18775308; 18840095; 18840627; 19009018; 19122331; 19154631; 19170196; 19176362; 19237300; 19265690; 19321437; 19380033; 19389935; 19403667; 19412428; 19416856; 19420237; 19435892; 19470730; 19471022; 19530237; 19543371; 19564049; 19622636; 19625176; 19669932; 19692168; 19722195; 19735688; 19751410; 19941857; 19958799; 20013084; 20170659; 20211142; 20368688; 20421453; 20688044; 20955178; 20980528; 21050047; 21061914; 21085187; 21129256; 21129257; 21138464; 21138840; 21233347; 21385877; 21423203; 21660045; 21693764; 21858728; 21906983; 21924241; 21963094; 22002058; 22370484; 22427205; 22445760; 22469468; 22505724; 22644804; 22669460; 22679299; 22787145; 22925926; 22960999; 23184933; 23277279; 23335490; 23421912; 23447676; 23470653; 23510626; 23560553; 23661758; 23737521; 24027308; 24029229; 24165480
description: X-box binding protein 1
database cross reference: Ensembl:ENSG00000100219
database cross reference: HGNC:12801
database cross reference: HPRD:01908
database cross reference: MIM:194355
database cross reference: Vega:OTTHUMG00000151094

ZAP70
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SRK
alternative term: STCD
alternative term: STD
alternative term: TZK
alternative term: ZAP-70
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ZAP70
full name from nomenclature authority: zeta-chain (TCR) associated protein kinase 70kDa
NCBI GeneID: 7535
gene map location: 2q12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001772 (EC: IEA); GO_0001784 (EC: IEA); GO_0002250 (EC: TAS); GO_0004713 (EC: IDA, PMID: 12447358); GO_0004713 (EC: NAS, PMID: 1423621); GO_0004713 (EC: TAS); GO_0004715 (EC: TAS); GO_0005515 (EC: IPI, PMID: 10318843); GO_0005524 (EC: NAS, PMID: 1423621); GO_0005737 (EC: TAS, PMID: 12359715); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 12150984); GO_0005886 (EC: TAS); GO_0006468 (EC: IDA, PMID: 12447358); GO_0006468 (EC: NAS, PMID: 1423621); GO_0006955 (EC: IDA, PMID: 1423621); GO_0018108 (EC: IDA); GO_0030217 (EC: NAS, PMID: 8613493); GO_0035556 (EC: NAS, PMID: 1423621); GO_0042101 (EC: IDA, PMID: 8176201); GO_0042110 (EC: TAS); GO_0042113 (EC: TAS); GO_0043366 (EC: IEA); GO_0045059 (EC: IDA, PMID: 7630421); GO_0045060 (EC: IEA); GO_0045121 (EC: IDA, Qualifier: colocalizes_with, PMID: 12150984); GO_0045582 (EC: IDA, PMID: 7630421); GO_0046638 (EC: IEA); GO_0046641 (EC: IEA); GO_0046777 (EC: IEA); GO_0050850 (EC: IEA); GO_0050852 (EC: TAS); GO_0070489 (EC: TAS); GO_0072678 (EC: TAS)
has PubMed association: PMID: 1423621; 7522245; 7528772; 7539035; 7629168; 7630421; 7737297; 7760813; 7761456; 7798261; 7819147; 7961936; 8082894; 8176201; 8202712; 8202713; 8366117; 8530437; 8613493; 8621646; 8638162; 8702662; 8756661; 8761298; 8798643; 8906806; 8943371; 9036949; 9047237; 9169414; 9269777; 9362531; 9378960; 9403695; 9407100; 9464824; 9490415; 9685404; 9698567; 9846481; 9988730; 10037717; 10074432; 10078535; 10209036; 10221598; 10318843; 10419455; 10449770; 10458769; 10660534; 10779765; 10790433; 10867021; 10966114; 10979964; 11048639; 11133830; 11279207; 11353765; 11368773; 11390470; 11412303; 11572860; 11781312; 11855827; 11891219; 11964272; 11976341; 12051764; 12084069; 12150984; 12154360; 12165490; 12186560; 12190313; 12359715; 12387734; 12393534; 12447358; 12450381; 12477932; 12504004; 12522270; 12595313; 12646565; 12648457; 12778467; 12817019; 12847255; 14523017; 14557276; 14560012; 14672952; 14766232; 14985102; 15059847; 15084271; 15100278; 15133473; 15143214; 15144186; 15190462; 15292186; 15358536; 15370248; 15489334; 15514014; 15536084; 15588985; 15592455; 15688026; 15699074; 15735648; 15759031; 15800671; 15856008; 15861514; 15923611; 15972449; 15996927; 16079094; 16079107; 16094384; 16096284; 16219325; 16263570; 16273093; 16291755; 16300468; 16339550; 16406604; 16412387; 16418492; 16461343; 16467082; 16467851; 16503409; 16538501; 16642047; 16823829; 16888650; 16906159; 16932341; 17038529; 17051526; 17192257; 17215865; 17222799; 17375875; 17492476; 17512407; 17534928; 17577788; 17652306; 17702857; 17767948; 17785822; 17926183; 17931624; 17948236; 18005690; 18022252; 18025306; 18029348; 18048647; 18190465; 18203013; 18311544; 18322442; 18333847; 18424730; 18453590; 18519230; 18577710; 18616755; 18683785; 18687687; 18689273; 18757853; 18770822; 18770856; 18818202; 18854088; 19018007; 19021053; 19050243; 19136305; 19230824; 19267204; 19297020; 19298946; 19377082; 19454010; 19575876; 19679010; 19710135; 19727816; 19826250; 19907441; 19920178; 19944462; 20001236; 20014…
description: zeta-chain (TCR) associated protein kinase 70kDa
database cross reference: Ensembl:ENSG00000115085
database cross reference: HGNC:12858
database cross reference: HPRD:01495
database cross reference: MIM:176947
database cross reference: Vega:OTTHUMG00000153060

ZNF224
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BMZF-2
alternative term: BMZF2
alternative term: KOX22
alternative term: ZNF255
alternative term: ZNF27
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ZNF224
full name from nomenclature authority: zinc finger protein 224
NCBI GeneID: 7767
gene map location: 19q13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003677 (EC: IEA); GO_0003700 (EC: IBA); GO_0005515 (EC: IPI); GO_0005634 (EC: IDA); GO_0006351 (EC: IEA); GO_0017053 (EC: IDA); GO_0031965 (EC: IDA); GO_0045892 (EC: IDA); GO_0046872 (EC: IEA)
has PubMed association: PMID: 2288909; 10585455; 12239212; 12477932; 12527367; 12743021; 15302935; 15489334; 15576338; 16150558; 16344560; 17900823; 19118814; 19505435; 19741270; 20379614; 20574532; 20587513; 20591825; 21187159; 23362234
description: zinc finger protein 224
database cross reference: Ensembl:ENSG00000267680
database cross reference: HGNC:13017
database cross reference: HPRD:06094
database cross reference: MIM:194555
database cross reference: Vega:OTTHUMG00000182313

LRP8
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: molecularly interacts with
  some values from: APOE
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APOER2
alternative term: HSZ75190
alternative term: LRP-8
alternative term: MCI1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LRP8
full name from nomenclature authority: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
NCBI GeneID: 7804
NCBI LocusTag: RP5-1024G6.8
gene map location: 1p34
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: ISS); GO_0001523 (EC: TAS); GO_0004888 (EC: TAS, PMID: 8626535); GO_0005509 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12950167); GO_0005576 (EC: IEA); GO_0005875 (EC: IEA); GO_0005886 (EC: TAS); GO_0005901 (EC: IDA, PMID: 11369809); GO_0006508 (EC: NAS, PMID: 11152697); GO_0006629 (EC: NAS, PMID: 11152697); GO_0006897 (EC: IDA, PMID: 8626535); GO_0006898 (EC: IDA, PMID: 8626535); GO_0007165 (EC: TAS, PMID: 10380922); GO_0007596 (EC: TAS); GO_0007603 (EC: TAS); GO_0008035 (EC: IEA); GO_0014069 (EC: IEA); GO_0016021 (EC: IC, PMID: 11152697); GO_0019221 (EC: NAS, PMID: 11152697); GO_0019894 (EC: IEA); GO_0021541 (EC: ISS); GO_0021819 (EC: IEA); GO_0030229 (EC: IDA, PMID: 8626535); GO_0030425 (EC: IEA); GO_0032793 (EC: ISS); GO_0034185 (EC: IC, PMID: 8626535); GO_0038025 (EC: ISS); GO_0038026 (EC: ISS); GO_0042493 (EC: IEA); GO_0043025 (EC: IEA); GO_0043235 (EC: IDA); GO_0050731 (EC: ISS); GO_0050804 (EC: ISS); GO_0061003 (EC: ISS); GO_0061098 (EC: ISS); GO_0071363 (EC: IEA); GO_0071397 (EC: IEA); GO_1900006 (EC: ISS)
has PubMed association: PMID: 8626535; 9079678; 10218790; 10231386; 10380922; 10508213; 10571240; 10827173; 11152697; 11369809; 12167620; 12169628; 12399018; 12426372; 12477932; 12621059; 12670700; 12681505; 12807892; 12824284; 12871934; 12899622; 12950167; 14702039; 14732905; 15313836; 15459198; 15489334; 15950758; 16034672; 16332682; 16481437; 16642433; 16951405; 17470198; 17614163; 17847002; 18039658; 18089558; 18489431; 18592168; 19056482; 19116273; 19282863; 19439088; 19661487; 19720620; 19913121; 19948739; 20208369; 20331378; 20493228; 20628086; 21157031; 21316997; 21347244; 21554715; 21601501; 21906983; 21963094; 22109552; 22170052; 22404453; 22419519; 22589174; 22889673; 23192594; 23524007; 23739027
description: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
relation: Alzpathway: LRP8-APOE association. Source: https://pubmed.ncbi.nlm.nih.gov/17428983/
database cross reference: HGNC:6700
database cross reference: HPRD:04002
database cross reference: MIM:602600

CXCR4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD184
alternative term: D2S201E
alternative term: FB22
alternative term: HM89
alternative term: HSY3RR
alternative term: LAP3
alternative term: LCR1
alternative term: LESTR
alternative term: NPY3R
alternative term: NPYR
alternative term: NPYRL
alternative term: NPYY3R
alternative term: WHIM
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CXCR4
full name from nomenclature authority: chemokine (C-X-C motif) receptor 4
NCBI GeneID: 7852
gene map location: 2q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: TAS, PMID: 10570282); GO_0001569 (EC: IEA); GO_0001618 (EC: IEA); GO_0001666 (EC: IEP, PMID: 15174142); GO_0001667 (EC: IEA); GO_0001764 (EC: IEA); GO_0002407 (EC: TAS, PMID: 16621978); GO_0003779 (EC: IDA, PMID: 12421915); GO_0004930 (EC: TAS, PMID: 8276799); GO_0005515 (EC: IPI, PMID: 10644702); GO_0005737 (EC: TAS, PMID: 10415069); GO_0005764 (EC: IDA); GO_0005769 (EC: IDA); GO_0005770 (EC: IDA); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0006915 (EC: TAS, PMID: 10942389); GO_0006954 (EC: TAS, PMID: 8276799); GO_0007186 (EC: IDA, PMID: 10644702); GO_0007204 (EC: TAS, PMID: 10228019); GO_0007281 (EC: IEA); GO_0007420 (EC: IEA); GO_0008045 (EC: IEA); GO_0008354 (EC: IEA); GO_0009615 (EC: TAS, PMID: 10583963); GO_0009897 (EC: IEA); GO_0009986 (EC: IDA, PMID: 10521508); GO_0015026 (EC: TAS, PMID: 10754293); GO_0016021 (EC: IEA); GO_0016023 (EC: IDA, PMID: 19106094); GO_0016032 (EC: TAS); GO_0016494 (EC: NAS, PMID: 9468539); GO_0019722 (EC: IMP, PMID: 19064997); GO_0019955 (EC: IEA); GO_0030054 (EC: IEA); GO_0030260 (EC: TAS); GO_0030334 (EC: IEA); GO_0030426 (EC: IEA); GO_0031252 (EC: IDA, PMID: 12421915); GO_0031410 (EC: IDA, PMID: 10521508); GO_0031625 (EC: IPI, PMID: 19116316); GO_0032027 (EC: IDA, PMID: 12421915); GO_0042098 (EC: IEA); GO_0042119 (EC: IEA); GO_0043130 (EC: IDA); GO_0043217 (EC: ISS); GO_0048714 (EC: ISS); GO_0050920 (EC: IMP, PMID: 19106094); GO_0061351 (EC: IEA); GO_0070062 (EC: IDA); GO_0070098 (EC: NAS, PMID: 9468539); GO_0071345 (EC: IDA)
has PubMed association: PMID: 1187744; 2834384; 7505609; 7592830; 8234909; 8276799; 8325644; 8329116; 8629022; 8640552; 8674119; 8752280; 8752281; 8805353; 8849450; 8898753; 8929542; 8976200; 8995603; 9020356; 9024623; 9031325; 9151868; 9184207; 9261451; 9300725; 9302439; 9359702; 9362541; 9379028; 9461627; 9468539; 9499113; 9499115; 9599023; 9600268; 9601645; 9614108; 9632631; 9634237; 9634238; 9653051; 9653130; 9658081; 9696823; 9710449; 9721247; 9736741; 9744279; 9765440; 9770524; 9780207; 9826718; 9879064; 9882290; 9933168; 9973525; 10029247; 10074122; 10089882; 10228019; 10229873; 10233851; 10329539; 10339592; 10357469; 10358157; 10364484; 10370370; 10371171; 10393923; 10393974; 10415069; 10430052; 10438703; 10438870; 10446313; 10449282; 10452968; 10480633; 10482576; 10487781; 10505675; 10506573; 10521508; 10544150; 10555208; 10559349; 10570282; 10582593; 10583963; 10585143; 10590105; 10590121; 10600606; 10602722; 10623764; 10644702; 10651866; 10669334; 10704341; 10738970; 10754293; 10756055; 10758170; 10772939; 10801487; 10802710; 10816381; 10825158; 10860877; 10864687; 10875613; 10877489; 10903911; 10903920; 10941932; 10942389; 11005830; 11024154; 11027346; 11069996; 11086073; 11115360; 11118068; 11119612; 11141237; 11153675; 11157475; 11162626; 11162839; 11175286; 11264367; 11265761; 11278278; 11278567; 11313374; 11333905; 11342415; 11356952; 11356967; 11390582; 11390601; 11397808; 11408611; 11413305; 11414813; 11426226; 11462036; 11464139; 11468147; 11489906; 11517394; 11529558; 11533159; 11551942; 11559423; 11591141; 11591370; 11595336; 11602639; 11602715; 11641392; 11668182; 11679153; 11689632; 11693435; 11698270; 11709091; 11711593; 11711617; 11751889; 11752220; 11799176; 11861874; 11867624; 11876757; 11877445; 11878912; 11880384; 11912162; 11920324; 11929756; 11931835; 11937572; 11953881; 11983855; 11994484; 11994538; 12004084; 12034737; 12091904; 12093918; 12163560; 12171912; 12193696; 12208881; 12218052; 12239139; 12239174; 12351385; 12354773; 12355376; 12356205; 12368305; 1…
description: chemokine (C-X-C motif) receptor 4
database cross reference: Ensembl:ENSG00000121966
database cross reference: HGNC:2561
database cross reference: HPRD:01217
database cross reference: MIM:162643
database cross reference: Vega:OTTHUMG00000153583

PICALM
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CALM
alternative term: CLTH
alternative term: LAP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PICALM
full name from nomenclature authority: phosphatidylinositol binding clathrin assembly protein
NCBI GeneID: 8301
gene map location: 11q14
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 16491119); GO_0005545 (EC: ISS); GO_0005634 (EC: IDA, PMID: 16491119); GO_0005794 (EC: IEA); GO_0005905 (EC: IDA, PMID: 10436022); GO_0005905 (EC: ISS); GO_0006461 (EC: TAS, PMID: 8643484); GO_0006898 (EC: IDA, PMID: 10436022); GO_0006898 (EC: ISS); GO_0007409 (EC: IEA); GO_0016192 (EC: TAS, PMID: 8643484); GO_0016197 (EC: IMP, PMID: 16262731); GO_0030097 (EC: IEA); GO_0030100 (EC: IMP, PMID: 18182011); GO_0030122 (EC: IDA, Qualifier: colocalizes_with, PMID: 16262731); GO_0030132 (EC: IDA, Qualifier: colocalizes_with, PMID: 10436022); GO_0030276 (EC: IDA, PMID: 10436022); GO_0030276 (EC: ISS); GO_0031623 (EC: IMP, PMID: 14985334); GO_0032050 (EC: IDA, PMID: 10436022); GO_0032880 (EC: IDA, PMID: 10436022); GO_0042734 (EC: ISS); GO_0043231 (EC: IDA); GO_0045211 (EC: ISS); GO_0045893 (EC: IDA, PMID: 11425879); GO_0048261 (EC: IDA, PMID: 10436022); GO_0048268 (EC: IMP, PMID: 16262731); GO_0048471 (EC: ISS, Qualifier: colocalizes_with); GO_0048813 (EC: IEA)
has PubMed association: PMID: 1547942; 8643484; 9737689; 10436022; 10926122; 11425879; 12461747; 12477932; 14702039; 14985334; 15146197; 15182197; 15489334; 16262731; 16491119; 17097559; 17170719; 17597474; 17804713; 18029348; 18037964; 18074379; 18094714; 18182011; 19450545; 19734902; 19738201; 20460622; 20534741; 20554627; 20558387; 20570404; 20674675; 20697030; 20738160; 20739100; 20838239; 20951388; 21059989; 21139048; 21220176; 21221849; 21297266; 21300948; 21347408; 21358043; 21460841; 21627779; 21706055; 21890473; 21906983; 21912625; 21963094; 21965661; 21987572; 21988832; 22015308; 22064352; 22402018; 22539346; 22539578; 22558309; 22623428; 22639918; 22715855; 22832961; 22888099; 22889924; 22939629; 22943764; 22952074; 22975751; 23040034; 23382074; 23487024; 23572399; 23601808; 23650005; 23670296; 23741335; 23870418; 24067654; 24076290
description: phosphatidylinositol binding clathrin assembly protein
database cross reference: Ensembl:ENSG00000073921
database cross reference: HGNC:15514
database cross reference: HPRD:04320
database cross reference: MIM:603025
database cross reference: Vega:OTTHUMG00000166981

AXIN1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AXIN
alternative term: PPP1R49
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: AXIN1
full name from nomenclature authority: axin 1
NCBI GeneID: 8312
NCBI LocusTag: LA16c-314G4.3
gene map location: 16p13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000209 (EC: IEA); GO_0001701 (EC: IEA); GO_0001743 (EC: IBA); GO_0001934 (EC: IDA, PMID: 9601641); GO_0004871 (EC: IDA, PMID: 9601641); GO_0005096 (EC: IBA); GO_0005102 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10644691); GO_0005634 (EC: IDA, PMID: 12072559); GO_0005737 (EC: IDA, PMID: 12072559); GO_0005794 (EC: IEA); GO_0005829 (EC: TAS); GO_0005881 (EC: IBA); GO_0005938 (EC: IBA); GO_0006913 (EC: IEA); GO_0006915 (EC: IEA); GO_0007257 (EC: IBA); GO_0007368 (EC: IBA); GO_0007605 (EC: IEA); GO_0008013 (EC: IDA, PMID: 10644691); GO_0008022 (EC: IEA); GO_0008219 (EC: IBA); GO_0009950 (EC: IBA); GO_0010800 (EC: NAS, PMID: 18593713); GO_0014069 (EC: IBA); GO_0016023 (EC: IBA); GO_0016328 (EC: IDA, PMID: 12072559); GO_0019899 (EC: IPI, PMID: 19759537); GO_0019901 (EC: IBA); GO_0019901 (EC: ISS); GO_0021797 (EC: IBA); GO_0021881 (EC: IBA); GO_0030163 (EC: IEA); GO_0030178 (EC: IDA, PMID: 10644691); GO_0030511 (EC: IEA); GO_0030877 (EC: IDA, PMID: 16188939); GO_0030910 (EC: IBA); GO_0031122 (EC: IBA); GO_0031398 (EC: NAS, PMID: 18593713); GO_0031410 (EC: ISS); GO_0031625 (EC: IPI, PMID: 16601693); GO_0032147 (EC: IDA, PMID: 9601641); GO_0032436 (EC: IEA); GO_0032947 (EC: IDA, PMID: 9601641); GO_0032947 (EC: IMP, PMID: 16601693); GO_0033138 (EC: NAS, PMID: 18593713); GO_0034244 (EC: IEA); GO_0035412 (EC: IBA); GO_0036342 (EC: IEA); GO_0038032 (EC: IEA); GO_0042802 (EC: ISS); GO_0042803 (EC: ISS); GO_0043547 (EC: IBA); GO_0043621 (EC: IEA); GO_0043623 (EC: IDA, PMID: 16601693); GO_0045599 (EC: IBA); GO_0045732 (EC: IC, PMID: 16188939); GO_0045732 (EC: IDA, PMID: 9601641); GO_0045893 (EC: IMP, PMID: 16601693); GO_0046330 (EC: ISS); GO_0046332 (EC: IPI, PMID: 18593713); GO_0048048 (EC: IBA); GO_0048320 (EC: IBA); GO_0048471 (EC: IDA, PMID: 19038973); GO_0051248 (EC: IEA); GO_0051260 (EC: IEA); GO_0051443 (EC: IMP, PMID: 16601693); GO_0055001 (EC: IBA); GO_0060070 (EC: IC, PMID: 9601641); GO_0060272 (EC: IBA); GO_0060823 (EC: IBA); GO_0070016 (EC: IBA); GO_0070016 (EC: ISS); GO…
has PubMed association: PMID: 9054936; 9230313; 9335612; 9482734; 9601641; 9734785; 9920888; 10228155; 10330403; 10428961; 10488109; 10581160; 10644691; 10698523; 10700176; 10811618; 10829020; 11157797; 11297546; 11336703; 11438668; 11487578; 11557983; 11719457; 11809808; 11884395; 11955436; 11997515; 12000790; 12036951; 12072559; 12101426; 12138115; 12192039; 12209999; 12223491; 12417018; 12421363; 12477932; 12511557; 12554650; 12555076; 12556519; 12584189; 12717450; 12771989; 12805222; 12820959; 12883680; 12897152; 14534723; 14566817; 14630927; 14970870; 15063782; 15064706; 15262978; 15327769; 15355978; 15489334; 15520370; 15526030; 15579909; 15616553; 15698401; 15981102; 16163548; 16169070; 16188939; 16199882; 16293619; 16601693; 16753179; 16772034; 16773576; 16868183; 16890161; 17018282; 17143297; 17210684; 17318175; 17353931; 17418091; 17510365; 17569865; 17588722; 17720811; 17768662; 18171349; 18330950; 18514389; 18593713; 18632848; 18708403; 18762581; 19038973; 19107203; 19131971; 19141611; 19202075; 19249679; 19303846; 19331826; 19390532; 19453261; 19513548; 19582507; 19633924; 19731416; 19759537; 19778269; 19913121; 20098615; 20122174; 20128690; 20379614; 20531388; 20628086; 20844743; 20846493; 20858899; 21057547; 21087614; 21242974; 21383061; 21478859; 21502811; 21648318; 21769465; 21795712; 21799911; 21808024; 21902576; 21988832; 22234612; 22270359; 22504420; 22509369; 22524844; 22613765; 22614067; 22682247; 22933777; 23110995; 23192643; 23277359; 23278310; 23455922; 23525311; 23602568; 23671587; 23826318; 23879168; 23915259; 23959799; 24011952
description: axin 1
database cross reference: Ensembl:ENSG00000103126
database cross reference: HGNC:903
database cross reference: HPRD:04819
database cross reference: MIM:603816
database cross reference: Vega:OTTHUMG00000064930

AXIN2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AXIL
alternative term: ODCRCS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: AXIN2
full name from nomenclature authority: axin 2
NCBI GeneID: 8313
gene map location: 17q23-q24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001934 (EC: IMP); GO_0001957 (EC: IBA); GO_0003413 (EC: IEA); GO_0004871 (EC: IEA); GO_0005096 (EC: IBA); GO_0005515 (EC: IPI, PMID: 10698523); GO_0005634 (EC: IDA, PMID: 12072559); GO_0005737 (EC: IDA); GO_0005813 (EC: IDA); GO_0005881 (EC: IBA); GO_0005886 (EC: IBA); GO_0005938 (EC: IBA); GO_0008013 (EC: IBA); GO_0008013 (EC: NAS, PMID: 11017067); GO_0008283 (EC: IEA); GO_0008285 (EC: IMP, PMID: 16247484); GO_0009950 (EC: IBA); GO_0010718 (EC: IMP, PMID: 17072303); GO_0010942 (EC: IMP, PMID: 16247484); GO_0014069 (EC: IBA); GO_0016023 (EC: IBA); GO_0019899 (EC: IPI, PMID: 19759537); GO_0019901 (EC: IBA); GO_0030282 (EC: IEA); GO_0030877 (EC: NAS, PMID: 11017067); GO_0031625 (EC: IPI); GO_0032423 (EC: IMP, PMID: 11017067); GO_0034613 (EC: IDA, PMID: 17072303); GO_0035414 (EC: IMP, PMID: 11017067); GO_0038032 (EC: IEA); GO_0042476 (EC: IMP, PMID: 15042511); GO_0043547 (EC: IBA); GO_0043570 (EC: IMP, PMID: 18755497); GO_0045668 (EC: IBA); GO_0048255 (EC: IMP, PMID: 17072303); GO_0061181 (EC: IEA); GO_0070016 (EC: IBA); GO_0070411 (EC: IEA); GO_0070602 (EC: IMP); GO_0071407 (EC: IBA); GO_0090090 (EC: IDA, PMID: 11940574); GO_0090090 (EC: IMP, PMID: 11017067); GO_0090244 (EC: IBA)
has PubMed association: PMID: 8889548; 9566905; 10021369; 10049590; 10647780; 10698523; 10966653; 11017067; 11438668; 11474173; 11940574; 12072559; 12183362; 12477932; 15042511; 15304487; 15489334; 15611123; 15766563; 16247484; 16344560; 16432638; 16601693; 16820935; 16941501; 17002498; 17072303; 17143297; 17373666; 17927870; 18330950; 18372914; 18384130; 18676680; 18683894; 18708403; 18755497; 18790474; 19065536; 19119171; 19170196; 19270026; 19336002; 19584075; 19623616; 19625176; 19692168; 19759537; 19816326; 19888426; 20056645; 20128690; 20219685; 20300119; 20403997; 20453000; 20508983; 20613673; 20635389; 20844743; 21069480; 21294210; 21383061; 21541676; 21626677; 21666490; 21706018; 21733995; 21799911; 21890473; 22322943; 22370446; 22745173; 22887353; 23169889; 23393221; 23455922; 23516639; 23602568; 23624843
description: axin 2
database cross reference: Ensembl:ENSG00000168646
database cross reference: HGNC:904
database cross reference: HPRD:04935
database cross reference: MIM:604025
database cross reference: Vega:OTTHUMG00000179353

ULK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ATG1
alternative term: ATG1A
alternative term: UNC51
alternative term: Unc51.1
alternative term: hATG1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ULK1
full name from nomenclature authority: unc-51 like autophagy activating kinase 1
NCBI GeneID: 8408
gene map location: 12q24.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000045 (EC: IEA); GO_0004674 (EC: IDA, PMID: 18936157); GO_0004674 (EC: NAS, PMID: 9693035); GO_0005515 (EC: IPI, PMID: 11146101); GO_0005524 (EC: IEA); GO_0005737 (EC: NAS, PMID: 9693035); GO_0005776 (EC: IDA, PMID: 17595159); GO_0005829 (EC: IDA, PMID: 11146101); GO_0006468 (EC: NAS, PMID: 9693035); GO_0007265 (EC: IEA); GO_0008104 (EC: IMP, PMID: 16940348); GO_0010506 (EC: IDA, PMID: 18936157); GO_0010506 (EC: IMP, PMID: 17595159); GO_0010508 (EC: ISS); GO_0016239 (EC: IMP); GO_0017137 (EC: IPI); GO_0019901 (EC: IEA); GO_0021707 (EC: IEA); GO_0021933 (EC: IEA); GO_0030659 (EC: IEA); GO_0031102 (EC: IEA); GO_0031175 (EC: IMP, PMID: 18007665); GO_0031623 (EC: IEA); GO_0031669 (EC: ISS); GO_0032403 (EC: IPI, PMID: 19211835); GO_0034045 (EC: IDA, PMID: 18936157); GO_0042594 (EC: ISS); GO_0043005 (EC: IEA); GO_0043025 (EC: IEA); GO_0046777 (EC: IDA, PMID: 18936157); GO_0048671 (EC: IEA); GO_0048675 (EC: IEA); GO_0051386 (EC: IEA); GO_0070969 (EC: IPI, PMID: 19211835)
has PubMed association: PMID: 8889548; 9693035; 9872452; 11076863; 11146101; 12477932; 14702039; 15014045; 16940348; 17081983; 17192257; 17353931; 17595159; 18007665; 18936157; 19211835; 19225151; 19258318; 19287211; 19690328; 20562859; 20921139; 21072212; 21205641; 21258367; 21460630; 21460634; 21475306; 21518141; 21560199; 21795849; 21819378; 22321011; 22539723; 22585231; 22613832; 22885598; 23027865; 23043107; 23078367; 23291726; 23455922; 23524951; 23716696; 23863160; 24119841
description: unc-51 like autophagy activating kinase 1
database cross reference: Ensembl:ENSG00000177169
database cross reference: HGNC:12558
database cross reference: HPRD:11933
database cross reference: MIM:603168
database cross reference: Vega:OTTHUMG00000168052

OGT
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HRNT1
alternative term: O-GLCNAC
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: OGT
full name from nomenclature authority: O-linked N-acetylglucosamine (GlcNAc) transferase
NCBI GeneID: 8473
gene map location: Xq13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000123 (EC: IDA); GO_0005515 (EC: IPI, PMID: 12150998); GO_0005547 (EC: IDA, PMID: 18288188); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005739 (EC: IEA); GO_0005815 (EC: IDA); GO_0005829 (EC: IDA); GO_0005886 (EC: IDA); GO_0006110 (EC: IDA); GO_0006325 (EC: TAS); GO_0006493 (EC: IDA); GO_0006493 (EC: IMP); GO_0006915 (EC: IDA); GO_0007165 (EC: TAS, PMID: 9083067); GO_0007584 (EC: TAS, PMID: 9083068); GO_0008047 (EC: IDA); GO_0008375 (EC: TAS, PMID: 9083068); GO_0016262 (EC: IDA); GO_0030854 (EC: IMP); GO_0031397 (EC: ISS); GO_0032868 (EC: IDA, PMID: 18288188); GO_0032922 (EC: ISS); GO_0035020 (EC: IDA, PMID: 18288188); GO_0043085 (EC: IDA); GO_0043981 (EC: IDA); GO_0043982 (EC: IDA); GO_0043984 (EC: IDA); GO_0043995 (EC: IDA, Qualifier: contributes_to); GO_0043996 (EC: IDA, Qualifier: contributes_to); GO_0045862 (EC: IDA); GO_0045944 (EC: IDA); GO_0045944 (EC: IMP); GO_0046626 (EC: IDA, PMID: 18288188); GO_0046972 (EC: IDA, Qualifier: contributes_to); GO_0048015 (EC: IDA, PMID: 18288188); GO_0051571 (EC: IDA); GO_0061087 (EC: IMP); GO_0070688 (EC: IDA); GO_0071300 (EC: IMP); GO_0080182 (EC: IMP); GO_0090526 (EC: ISS); GO_0097363 (EC: ISS)
has PubMed association: PMID: 1512232; 1533623; 1730617; 7642555; 8063760; 8076819; 8344946; 8619474; 8639509; 8702840; 8910513; 9083067; 9083068; 9110174; 9343410; 9499386; 10386995; 10580430; 10753899; 10801981; 11773972; 11846551; 12136128; 12150998; 12226704; 12373287; 12435728; 12477932; 12504895; 12538765; 12670868; 12724313; 12911634; 14601650; 15336570; 15489334; 15561949; 15795231; 15896326; 16105839; 16189514; 16344560; 16434389; 16449650; 16505006; 16966374; 17000644; 17353931; 17882263; 18029348; 18174169; 18288188; 18536723; 18653473; 18781797; 19073609; 19615732; 19932102; 20068230; 20190804; 20200153; 20206135; 20360068; 20479123; 20628624; 20805223; 20805357; 20824293; 20845477; 20876116; 21081666; 21139048; 21240259; 21252943; 21285374; 21295698; 21327254; 21567137; 21890473; 21906983; 21963094; 21987572; 22053931; 22072767; 22275356; 22294689; 22307082; 22311971; 22371499; 22384635; 22496241; 22505724; 22574218; 22783592; 22863883; 22883232; 22939629; 23000965; 23088713; 23103939; 23103942; 23152511; 23184937; 23222540; 23246001; 23487789; 23642195; 23700425; 23720054; 24256146; 24311690
description: O-linked N-acetylglucosamine (GlcNAc) transferase
database cross reference: Ensembl:ENSG00000147162
database cross reference: HGNC:8127
database cross reference: HPRD:02222
database cross reference: MIM:300255
database cross reference: Vega:OTTHUMG00000033316

GALR3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GALR3
full name from nomenclature authority: galanin receptor 3
NCBI GeneID: 8484
gene map location: 22q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 22
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004966 (EC: IEA); GO_0005886 (EC: TAS); GO_0007193 (EC: IEA); GO_0007194 (EC: IEA); GO_0007218 (EC: TAS, PMID: 9722565); GO_0007268 (EC: TAS, PMID: 9722565); GO_0007611 (EC: TAS, PMID: 9722565); GO_0007631 (EC: TAS, PMID: 9722565); GO_0016021 (EC: IEA)
has PubMed association: PMID: 2834384; 9722565; 9832121; 9928159; 10441207; 10591208; 11867941; 17083333; 18577758; 19086053; 20398908; 20677014; 20817064; 20848231; 22889491
description: galanin receptor 3

HAT1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: KAT1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HAT1
full name from nomenclature authority: histone acetyltransferase 1
NCBI GeneID: 8520
gene map location: 2q31.2-q33.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004402 (EC: IEA); GO_0005515 (EC: IPI, PMID: 19862764); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IEA); GO_0006323 (EC: TAS, PMID: 9427644); GO_0006325 (EC: TAS); GO_0006348 (EC: IEA); GO_0006475 (EC: TAS, PMID: 9427644); GO_0007584 (EC: IEA); GO_0016363 (EC: IEA); GO_0043231 (EC: IDA)
has PubMed association: PMID: 9427644; 10911985; 11329013; 11492997; 11585814; 12408818; 12477932; 12775419; 14718166; 15161933; 15489334; 15815621; 16344560; 17052979; 17081983; 17207965; 17609381; 18029348; 18458078; 18781797; 19410544; 19615732; 19815555; 19862764; 20080577; 20224553; 20504901; 20562859; 20639865; 20953179; 21139048; 21145461; 21890473; 21906983; 21963094; 21987572; 22053931; 22190034; 22228774; 22505724; 22615379; 22797925; 22863883; 22939629; 22990118; 23000965; 23281010; 23653357; 24116224
description: histone acetyltransferase 1
database cross reference: Ensembl:ENSG00000128708
database cross reference: HGNC:4821
database cross reference: HPRD:04339
database cross reference: MIM:603053
database cross reference: Vega:OTTHUMG00000132282

CASK
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CAGH39
alternative term: CAMGUK
alternative term: CMG
alternative term: FGS4
alternative term: LIN2
alternative term: MICPCH
alternative term: MRXSNA
alternative term: TNRC8
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CASK
full name from nomenclature authority: calcium/calmodulin-dependent serine protein kinase (MAGUK family)
NCBI GeneID: 8573
NCBI LocusTag: RP11-540L11.1
gene map location: Xp11.4
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001953 (EC: IMP, PMID: 18664494); GO_0004385 (EC: TAS, PMID: 9660868); GO_0004674 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11377421); GO_0005516 (EC: IEA); GO_0005524 (EC: IEA); GO_0005604 (EC: IDA, Qualifier: colocalizes_with, PMID: 18664494); GO_0005652 (EC: IDA, PMID: 18664494); GO_0005730 (EC: IDA, PMID: 18664494); GO_0005737 (EC: IDA, PMID: 18664494); GO_0005829 (EC: IEA); GO_0005886 (EC: TAS, PMID: 9660868); GO_0005911 (EC: IDA, PMID: 18664494); GO_0007155 (EC: TAS, PMID: 9660868); GO_0010839 (EC: IMP, PMID: 18664494); GO_0015629 (EC: TAS, PMID: 9660868); GO_0016323 (EC: IEA); GO_0016363 (EC: IDA, PMID: 18664494); GO_0030198 (EC: TAS); GO_0042043 (EC: IEA); GO_0042734 (EC: ISS); GO_0045944 (EC: IEA); GO_0046939 (EC: TAS, PMID: 9660868); GO_0060170 (EC: ISS); GO_0061045 (EC: IMP, PMID: 18664494); GO_0070509 (EC: IEA); GO_0090280 (EC: IEA); GO_0090288 (EC: IMP, PMID: 18664494)
has PubMed association: PMID: 8786425; 9225980; 9546224; 9660868; 9660869; 9722958; 9753324; 9822620; 9952408; 10455105; 10460248; 10749215; 10856295; 10993877; 11003712; 11036064; 11120739; 11356864; 11377421; 11679592; 11742811; 11880184; 12006486; 12040031; 12093160; 12110687; 12151521; 12151522; 12202822; 12351654; 12477932; 12511555; 12522552; 12641734; 12676536; 14627983; 14702039; 14960569; 15024025; 15066269; 15123239; 15231748; 15331416; 15673434; 15694377; 15729360; 16637659; 16688213; 16842202; 17287346; 18423203; 18629876; 18664494; 19019082; 19125693; 19165920; 19200522; 19322201; 19523119; 19615732; 19736351; 19781660; 19847910; 20006588; 20029458; 20623620; 21139048; 21590270; 21735175; 21763699; 21855798; 21890473; 21906983; 21954287; 21988832; 22389404; 22452838; 22709267; 23165780; 23406872; 23600800; 23602568; 23864692; 24250222; 24278995
description: calcium/calmodulin-dependent serine protein kinase (MAGUK family)
database cross reference: Ensembl:ENSG00000147044
database cross reference: HGNC:1497
database cross reference: HPRD:02164
database cross reference: MIM:300172
database cross reference: Vega:OTTHUMG00000021378

PDE5A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CGB-PDE
alternative term: CN5A
alternative term: PDE5
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PDE5A
full name from nomenclature authority: phosphodiesterase 5A, cGMP-specific
NCBI GeneID: 8654
gene map location: 4q27
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004114 (EC: NAS, PMID: 9714779); GO_0005575 (EC: ND); GO_0005829 (EC: TAS); GO_0007165 (EC: IEA); GO_0007596 (EC: TAS); GO_0010613 (EC: IEA); GO_0030553 (EC: TAS, PMID: 15938621); GO_0042130 (EC: IEA); GO_0043406 (EC: IEA); GO_0046069 (EC: IDA, PMID: 14687666); GO_0046069 (EC: IEA); GO_0046872 (EC: IEA); GO_0047555 (EC: IEA); GO_0055118 (EC: IEA); GO_0055119 (EC: IEA); GO_0060282 (EC: IEA)
has PubMed association: PMID: 2168396; 8557689; 8889548; 9115850; 9642111; 9714779; 9716380; 10393044; 10411650; 10679249; 10679255; 10859452; 11076863; 11162575; 11230166; 11358813; 11602184; 11896473; 12359732; 12477932; 12554648; 12604588; 12650945; 12955149; 14668322; 14687666; 14764637; 15093609; 15175637; 15240816; 15489334; 15489336; 15640438; 15817798; 15938621; 16381901; 16407275; 16690614; 17017938; 17138653; 17906676; 18029348; 18293931; 18635550; 18757735; 19139381; 19852267; 19961855; 19996273; 20177899; 20196613; 20308615; 20332099; 20332439; 20346360; 20351714; 20379614; 20491634; 20553468; 20555034; 20563733; 20590607; 20595799; 20861010; 21193396; 21215707; 21421555; 21425347; 21505183; 21525805; 21697861; 21736695; 21890473; 21987443; 22843873; 22960860; 23033484; 23527037
description: phosphodiesterase 5A, cGMP-specific
database cross reference: Ensembl:ENSG00000138735
database cross reference: HGNC:8784
database cross reference: HPRD:04497
database cross reference: MIM:603310
database cross reference: Vega:OTTHUMG00000132971

IRS2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IRS-2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IRS2
full name from nomenclature authority: insulin receptor substrate 2
NCBI GeneID: 8660
gene map location: 13q34
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 13
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002053 (EC: IEA); GO_0002903 (EC: ISS); GO_0004871 (EC: IEA); GO_0005158 (EC: IEA); GO_0005515 (EC: IPI, PMID: 17901049); GO_0005829 (EC: TAS); GO_0005886 (EC: TAS); GO_0006006 (EC: TAS, PMID: 9495343); GO_0007165 (EC: TAS, PMID: 7675087); GO_0007173 (EC: TAS); GO_0007420 (EC: IEA); GO_0008283 (EC: IEA); GO_0008284 (EC: NAS, PMID: 17925406); GO_0008286 (EC: ISS); GO_0008286 (EC: TAS); GO_0008543 (EC: TAS); GO_0009749 (EC: ISS); GO_0010748 (EC: IMP, PMID: 16814735); GO_0010907 (EC: IMP, PMID: 16814735); GO_0019216 (EC: TAS, PMID: 16814735); GO_0019901 (EC: IEA); GO_0019903 (EC: IEA); GO_0019904 (EC: IEA); GO_0030335 (EC: IEA); GO_0030879 (EC: IEA); GO_0030890 (EC: ISS); GO_0032000 (EC: IMP, PMID: 16814735); GO_0032024 (EC: ISS); GO_0032869 (EC: IMP, PMID: 16814735); GO_0033673 (EC: ISS); GO_0038095 (EC: TAS); GO_0043548 (EC: IEA); GO_0045087 (EC: TAS); GO_0045725 (EC: IMP, PMID: 16814735); GO_0045725 (EC: NAS, PMID: 17925406); GO_0046326 (EC: IMP, PMID: 16814735); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS); GO_0055088 (EC: TAS, PMID: 16814735); GO_0060397 (EC: TAS); GO_0071333 (EC: IEA); GO_0071889 (EC: IEA)
has PubMed association: PMID: 7499365; 7559579; 7675087; 7876077; 8550573; 8621590; 8626379; 8662806; 8732688; 8910607; 8938433; 8954948; 9113989; 9195949; 9295312; 9312143; 9334184; 9495343; 9535722; 9609109; 9648831; 9651339; 9651378; 9852124; 10077005; 10417350; 10480623; 10594015; 10679027; 10856136; 11030756; 11054408; 11147812; 11481324; 11505033; 11522686; 11600548; 11641236; 11872698; 11912194; 12052866; 12107746; 12167717; 12189449; 12198247; 12213887; 12228220; 12379806; 12475767; 12477932; 12493740; 12519871; 12554758; 12660731; 12687350; 12732844; 12765968; 12783867; 12821935; 12933652; 12960006; 14534541; 14604996; 14653106; 14978080; 15057823; 15123681; 15127203; 15155816; 15161933; 15247132; 15292987; 15302935; 15308584; 15316008; 15324660; 15514089; 15588985; 15678496; 15778465; 15811564; 15926113; 15940190; 16030120; 16086274; 16127164; 16150916; 16448675; 16489531; 16652127; 16814735; 16839840; 16964243; 17030631; 17051426; 17068339; 17081983; 17222321; 17353931; 17361103; 17374994; 17416760; 17898946; 17901049; 17914103; 17925406; 17979178; 18059035; 18079194; 18271526; 18506362; 18611262; 18660489; 18802016; 18992263; 19038974; 19109239; 19124510; 19190347; 19259821; 19322201; 19332049; 19377890; 19447894; 19509476; 19561084; 19604268; 19690174; 19755487; 19818665; 19875459; 19878940; 19887537; 19913121; 19926323; 19929986; 20092705; 20184486; 20210696; 20354165; 20416077; 20416304; 20628086; 20634197; 20685959; 21042750; 21045156; 21258861; 21325637; 21340542; 21693764; 21700708; 21706016; 21771880; 21777391; 21801267; 21852217; 21890473; 21933986; 21984580; 22147666; 22205343; 22287730; 22465474; 22523112; 22623531; 22844442; 22912850; 22939629; 22974441; 22994406; 23018177; 23049845; 23147115; 23216712; 23251408; 23594372; 23617393; 23706954; 24255178; 24616100
description: insulin receptor substrate 2
database cross reference: Ensembl:ENSG00000185950
database cross reference: HGNC:6126
database cross reference: HPRD:02878
database cross reference: MIM:600797
database cross reference: Vega:OTTHUMG00000017338

BECN1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ATG6
alternative term: VPS30
alternative term: beclin1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BECN1
full name from nomenclature authority: beclin 1, autophagy related
NCBI GeneID: 8678
gene map location: 17q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000045 (EC: IEA); GO_0000910 (EC: IMP); GO_0001666 (EC: IEA); GO_0005515 (EC: IPI, PMID: 16417406); GO_0005634 (EC: IEA); GO_0005794 (EC: IEA); GO_0005802 (EC: IEA); GO_0006968 (EC: TAS, PMID: 9765397); GO_0007040 (EC: IEA); GO_0008285 (EC: IEA); GO_0016020 (EC: IEA); GO_0016023 (EC: IEA); GO_0016032 (EC: IEA); GO_0016239 (EC: IEA); GO_0030425 (EC: IEA); GO_0033197 (EC: IEA); GO_0042493 (EC: IEA); GO_0043066 (EC: TAS, PMID: 9765397); GO_0043234 (EC: IEA); GO_0048666 (EC: IEA); GO_0050435 (EC: IEA); GO_0051607 (EC: IEA); GO_0071275 (EC: IEA); GO_0071364 (EC: IEA)
has PubMed association: PMID: 7490091; 7829101; 8125298; 9765397; 10395800; 10604474; 11306555; 11309306; 11564866; 12372286; 12477932; 14966907; 14970205; 15489334; 15922724; 16267277; 16390869; 16417406; 16522639; 16713569; 16718815; 16857678; 16874027; 17203225; 17236580; 17272502; 17337444; 17355787; 17438366; 17441324; 17441338; 17446862; 17550384; 17589504; 17595761; 17643073; 17659302; 17786023; 17999086; 18005679; 18184403; 18184459; 18497881; 18497889; 18552835; 18628207; 18641390; 18769161; 18797192; 18829541; 18843052; 19050071; 19060920; 19066461; 19130303; 19145109; 19180116; 19218137; 19270693; 19270696; 19289499; 19298526; 19298604; 19318089; 19325567; 19347031; 19372752; 19375507; 19395874; 19520853; 19535901; 19535919; 19556884; 19635843; 19641499; 19680556; 19713971; 19762066; 19778902; 19798108; 19921231; 20004946; 20009549; 20010695; 20023428; 20037818; 20090905; 20150769; 20190558; 20206246; 20207475; 20230646; 20368806; 20454448; 20473282; 20501938; 20559548; 20562859; 20638385; 20639699; 20643123; 20697744; 20842118; 20863706; 20889974; 20921139; 20937944; 21081164; 21203962; 21209283; 21239722; 21327823; 21353614; 21358617; 21420796; 21444671; 21478185; 21499230; 21537144; 21543763; 21556768; 21610315; 21646862; 21654208; 21681342; 21711108; 21722286; 21729531; 21750416; 21769915; 21777947; 21779982; 21861179; 21873141; 21875280; 21890473; 21906983; 21936852; 21962518; 21971985; 21976705; 22039439; 22081109; 22095667; 22147978; 22157765; 22174682; 22219388; 22240664; 22242123; 22248718; 22286270; 22301112; 22310240; 22314358; 22335943; 22392728; 22393062; 22493499; 22498477; 22622204; 22627130; 22648564; 22650021; 22674982; 22733132; 22742832; 22797916; 22805532; 22875631; 22933281; 23029344; 23089287; 23112296; 23125008; 23184933; 23197835; 23216071; 23225331; 23264393; 23316280; 23334926; 23337876; 23420005; 23429496; 23444126; 23478334; 23479509; 23504944; 23525201; 23564079; 23569248; 23573264; 23703612; 23722017; 23737459; 23801739; 23812859; 23827971; 23877263…
description: beclin 1, autophagy related
database cross reference: Ensembl:ENSG00000126581
database cross reference: HGNC:1034
database cross reference: HPRD:05087
database cross reference: MIM:604378
database cross reference: Vega:OTTHUMG00000180653

MARCO
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SCARA2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MARCO
full name from nomenclature authority: macrophage receptor with collagenous structure
NCBI GeneID: 8685
gene map location: 2q14.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002221 (EC: TAS, PMID: 10331948); GO_0004888 (EC: TAS, PMID: 10331948); GO_0005044 (EC: IEA); GO_0005581 (EC: IEA); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 9468508); GO_0007166 (EC: TAS, PMID: 9468508); GO_0008329 (EC: TAS, PMID: 10331948); GO_0030666 (EC: TAS); GO_0043277 (EC: IEA); GO_0045087 (EC: IEA)
has PubMed association: PMID: 7867067; 9468508; 10331948; 10651831; 11315932; 11820786; 12097327; 12444143; 12477932; 12847263; 15489334; 16237101; 16335952; 19240061; 19403625; 20237496; 20810988; 21299846; 21886847; 21986627; 22470185; 22470186; 23154236; 23249958; 23617307; 23739639
description: macrophage receptor with collagenous structure
database cross reference: Ensembl:ENSG00000019169
database cross reference: HGNC:6895
database cross reference: HPRD:05337
database cross reference: MIM:604870
database cross reference: Vega:OTTHUMG00000131400

TNK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TNK1
full name from nomenclature authority: tyrosine kinase, non-receptor, 1
NCBI GeneID: 8711
gene map location: 17p13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004713 (EC: IDA, PMID: 10873601); GO_0004715 (EC: NAS, PMID: 10873601); GO_0004871 (EC: TAS, PMID: 8632913); GO_0005515 (EC: IPI, PMID: 10873601); GO_0005524 (EC: IDA, PMID: 10873601); GO_0005737 (EC: IDA, PMID: 10873601); GO_0005829 (EC: IEA); GO_0006468 (EC: TAS, PMID: 8632913); GO_0007165 (EC: TAS, PMID: 8632913); GO_0016020 (EC: IDA, PMID: 10873601); GO_0018108 (EC: IDA, PMID: 10873601); GO_0018108 (EC: TAS, PMID: 8632913); GO_0030054 (EC: IDA); GO_0030308 (EC: IEA); GO_0046580 (EC: IEA); GO_0046777 (EC: IDA, PMID: 10873601)
has PubMed association: PMID: 8125298; 8632913; 10873601; 12477932; 15489334; 15778465; 16344560; 17471239; 18830724; 18976975; 20090780; 20413850; 20534741; 20574532; 21536687; 21890473; 21906983; 22939624; 24449862
description: tyrosine kinase, non-receptor, 1

TRADD
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: Hs.89862
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TRADD
full name from nomenclature authority: TNFRSF1A-associated via death domain
NCBI GeneID: 8717
gene map location: 16q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004871 (EC: IEA); GO_0005164 (EC: IEA); GO_0005515 (EC: IPI, PMID: 1040062); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA, PMID: 11684708); GO_0005829 (EC: TAS); GO_0005856 (EC: IEA); GO_0006915 (EC: TAS); GO_0006919 (EC: TAS); GO_0007165 (EC: TAS, PMID: 7758105); GO_0008625 (EC: TAS, PMID: 8612133); GO_0019900 (EC: IPI, PMID: 8612133); GO_0031264 (EC: TAS, PMID: 18309324); GO_0032403 (EC: IEA); GO_0033209 (EC: TAS, PMID: 8612133); GO_0042802 (EC: IPI, PMID: 11684708); GO_0043065 (EC: TAS, PMID: 18309324); GO_0043123 (EC: IEP, PMID: 12761501); GO_0043235 (EC: IDA, PMID: 8612133); GO_0045121 (EC: IEA); GO_0051092 (EC: TAS, PMID: 18309324); GO_0051291 (EC: IEA); GO_0051798 (EC: IEA); GO_0060090 (EC: IPI, PMID: 8612133); GO_0070513 (EC: IPI, PMID: 8612133); GO_0097190 (EC: TAS); GO_0097191 (EC: IMP, PMID: 16611992); GO_0097191 (EC: TAS, PMID: 18309324); GO_2001239 (EC: TAS)
has PubMed association: PMID: 1040062; 7758105; 8565075; 8612133; 8621670; 8681376; 8702708; 8934525; 8943045; 9020361; 9082980; 9356494; 9427646; 9430227; 9560245; 9714541; 9915703; 9916731; 9916988; 10187805; 10356400; 10400625; 10544141; 10848577; 10892748; 10911999; 10980203; 11032752; 11035039; 11112409; 11112773; 11181075; 11226577; 11435712; 11479302; 11684708; 11821416; 11934887; 12045187; 12107169; 12417987; 12446787; 12477932; 12576460; 12604596; 12665801; 12753742; 12761501; 12796506; 12887920; 12911633; 14585990; 14644197; 14660619; 14702039; 14743216; 15103018; 15247912; 15310755; 15485837; 15489334; 15707590; 15761471; 16006552; 16227624; 16344560; 16603398; 16611992; 17051333; 17235653; 17540176; 17702576; 17922260; 18174230; 18198944; 18309324; 18661484; 18776134; 18939944; 18990758; 19151112; 19176810; 19287455; 19336370; 19379743; 19453261; 19573080; 19773279; 19781631; 19815541; 19854717; 20005846; 20568250; 20628368; 21068102; 21421854; 21724995; 21906983; 22099304; 22170762; 22179575; 22297296; 22510408; 22561347; 23732909; 23908590; 23955153; 23982205; 24130170; 24250222; 24374337
description: TNFRSF1A-associated via death domain
database cross reference: HGNC:12030
database cross reference: HPRD:04610
database cross reference: MIM:603500

HRK
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DP5
alternative term: HARAKIRI
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HRK
full name from nomenclature authority: harakiri, BCL2 interacting protein
NCBI GeneID: 8739
gene map location: 12q24.22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 14596824); GO_0005739 (EC: IDA, PMID: 15031724); GO_0006915 (EC: IEA); GO_0016021 (EC: IEA); GO_0032464 (EC: IDA); GO_0043065 (EC: IMP, PMID: 15031724); GO_0090200 (EC: IDA)
has PubMed association: PMID: 9130713; 9228060; 10075695; 11076863; 11331593; 11483855; 11796190; 12217801; 12477932; 12606589; 14596824; 14695142; 15031724; 15694340; 15721256; 16697956; 18008329; 18037991; 19322201; 19641496; 20379614; 20855536; 21209886; 21666788; 21731739; 22005931; 22504417; 22504421; 22773666; 22964433; 23090478; 23192964; 23580416
description: harakiri, BCL2 interacting protein
database cross reference: HGNC:5185
database cross reference: HPRD:04581
database cross reference: MIM:603447

RIPK2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CARD3
alternative term: CARDIAK
alternative term: CCK
alternative term: GIG30
alternative term: RICK
alternative term: RIP2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RIPK2
full name from nomenclature authority: receptor-interacting serine-threonine kinase 2
NCBI GeneID: 8767
NCBI LocusTag: WUGSC:H_RG437L15.1
gene map location: 8q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: TAS); GO_0001961 (EC: IEA); GO_0002224 (EC: TAS); GO_0002250 (EC: ISS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0002827 (EC: IEA); GO_0004674 (EC: IEA); GO_0004715 (EC: IEA); GO_0004871 (EC: TAS, PMID: 9642260); GO_0005515 (EC: IPI, PMID: 19337385); GO_0005524 (EC: IEA); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0005856 (EC: IDA); GO_0006915 (EC: IEA); GO_0006954 (EC: TAS, PMID: 9705938); GO_0007165 (EC: TAS, PMID: 9642260); GO_0007249 (EC: ISS); GO_0007254 (EC: TAS); GO_0010800 (EC: IDA); GO_0030274 (EC: IPI, PMID: 15657077); GO_0031398 (EC: IMP, PMID: 15620648); GO_0031398 (EC: NAS); GO_0031663 (EC: IEA); GO_0031982 (EC: IDA); GO_0032722 (EC: IEA); GO_0032727 (EC: NAS); GO_0032728 (EC: NAS); GO_0032729 (EC: IEA); GO_0032735 (EC: NAS); GO_0032743 (EC: IEA); GO_0032755 (EC: IEA); GO_0032760 (EC: IEA); GO_0033091 (EC: IEA); GO_0033138 (EC: IDA); GO_0034134 (EC: IDA, PMID: 11894098); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035666 (EC: TAS); GO_0035872 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042098 (EC: IEA); GO_0042803 (EC: IDA, PMID: 19337385); GO_0043065 (EC: IEA); GO_0043066 (EC: TAS); GO_0043123 (EC: IDA, PMID: 10329646); GO_0043234 (EC: IDA); GO_0043330 (EC: IEA); GO_0045087 (EC: IDA); GO_0045087 (EC: ISS); GO_0045087 (EC: TAS); GO_0045627 (EC: IEA); GO_0045944 (EC: NAS); GO_0046330 (EC: IEA); GO_0046641 (EC: IEA); GO_0048011 (EC: TAS); GO_0050700 (EC: IDA, PMID: 10329646); GO_0050700 (EC: IPI, PMID: 11087742); GO_0050731 (EC: IDA); GO_0050830 (EC: IEA); GO_0050852 (EC: ISS); GO_0050852 (EC: TAS); GO_0051092 (EC: IMP); GO_0051092 (EC: TAS); GO_0051403 (EC: TAS); GO_0070374 (EC: IEA); GO_0070423 (EC: TAS); GO_0070427 (EC: IEA); GO_0070431 (EC: IDA); GO_0070555 (EC: IEA); GO_0070671 (EC: IEA); GO_0070673 (EC: IEA); GO_0071223 (EC: IEA); GO_0071224 (EC: IEA); GO_0071225 (EC: IDA)
has PubMed association: PMID: 9575181; 9642260; 9705938; 10224040; 10329646; 10559258; 10719670; 10880512; 11087742; 11432859; 11487608; 11536016; 11894097; 11894098; 12138198; 12459189; 12477932; 12755636; 12761501; 12775719; 12938929; 12975309; 14638696; 15276183; 15489334; 15620648; 15657077; 15691841; 15761153; 16189514; 16344560; 16354923; 16418290; 16421571; 16492792; 16498402; 16517750; 16582588; 16824733; 16920334; 16997282; 17054981; 17075290; 17192257; 17348859; 17353931; 17355968; 17468049; 17851464; 17947236; 17965022; 18029348; 18079694; 18329614; 18342009; 18359207; 18426885; 18566542; 19121870; 19336552; 19337385; 19406482; 19464198; 19573080; 19592251; 19667203; 19693652; 19721713; 19773279; 19911254; 20018961; 20025869; 20125193; 20645315; 20800603; 20949042; 21048031; 21097508; 21123652; 21139048; 21757725; 21862576; 21887730; 21903422; 21906983; 21931591; 22075569; 22484241; 22504414; 22547678; 22607974; 22615316; 22665475; 22685397; 22815893; 22828789; 22993319; 23128233; 23300079; 23333941; 23437331; 23455924; 23818254; 23892723; 24015287; 24250222
description: receptor-interacting serine-threonine kinase 2
database cross reference: Ensembl:ENSG00000104312
database cross reference: HGNC:10020
database cross reference: HPRD:04585
database cross reference: MIM:603455
database cross reference: Vega:OTTHUMG00000163809

FADD
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MORT1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: FADD
full name from nomenclature authority: Fas (TNFRSF6)-associated via death domain
NCBI GeneID: 8772
NCBI LocusTag: GIG3
gene map location: 11q13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001916 (EC: ISS); GO_0002020 (EC: IPI, PMID: 9208847); GO_0002224 (EC: TAS); GO_0002756 (EC: TAS); GO_0002821 (EC: ISS); GO_0005123 (EC: TAS, PMID: 7538907); GO_0005164 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10442631); GO_0005829 (EC: TAS); GO_0006915 (EC: IMP); GO_0006915 (EC: TAS); GO_0006919 (EC: TAS); GO_0008625 (EC: TAS, PMID: 7538907); GO_0016032 (EC: IEA); GO_0031264 (EC: IDA, PMID: 11101870); GO_0031264 (EC: TAS, PMID: 18309324); GO_0031265 (EC: IDA); GO_0032729 (EC: ISS); GO_0032757 (EC: IDA, PMID: 16127453); GO_0032760 (EC: IDA, PMID: 16127453); GO_0032813 (EC: IPI); GO_0033077 (EC: ISS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0035666 (EC: TAS); GO_0035877 (EC: IPI, PMID: 11717445); GO_0042104 (EC: ISS); GO_0042802 (EC: IPI, PMID: 7536190); GO_0043005 (EC: IEA); GO_0043029 (EC: ISS); GO_0043065 (EC: IMP); GO_0043123 (EC: IEP, PMID: 12761501); GO_0044297 (EC: IEA); GO_0045087 (EC: TAS); GO_0045121 (EC: IEA); GO_0045651 (EC: IMP, PMID: 17047155); GO_0045862 (EC: IDA, PMID: 18387192); GO_0045944 (EC: IDA, PMID: 16127453); GO_0048535 (EC: ISS); GO_0048536 (EC: ISS); GO_0048538 (EC: ISS); GO_0051291 (EC: IEA); GO_0051607 (EC: IMP); GO_0060340 (EC: IMP); GO_0070236 (EC: ISS); GO_0071260 (EC: IEP, PMID: 19593445); GO_0097049 (EC: IEA); GO_0097190 (EC: IDA, PMID: 11101870); GO_0097190 (EC: TAS); GO_0097191 (EC: IDA); GO_0097191 (EC: IMP, PMID: 16611992); GO_0097191 (EC: TAS, PMID: 18309324); GO_0097192 (EC: IEA); GO_0097202 (EC: IDA, PMID: 18387192); GO_0097342 (EC: IDA); GO_0097527 (EC: IMP, PMID: 11101870); GO_1902043 (EC: IEA); GO_2000454 (EC: ISS); GO_2001238 (EC: IMP); GO_2001239 (EC: TAS)
has PubMed association: PMID: 7536190; 7538907; 8565075; 8681376; 8906799; 8955195; 8967952; 9037025; 9045686; 9082980; 9208847; 9215629; 9228018; 9325248; 9326610; 9430227; 9521326; 9560245; 9582077; 9721089; 9774341; 9990010; 10235259; 10442631; 10493725; 10542291; 10640736; 10825539; 10848577; 10880445; 10894160; 10911999; 11002422; 11034606; 11035039; 11048727; 11101870; 11112409; 11353862; 11376335; 11395500; 11717445; 11739185; 11740202; 11741985; 11752160; 11753396; 11805265; 11828002; 11854271; 11859150; 11877464; 11940602; 11965497; 11975981; 12037669; 12107169; 12122017; 12196516; 12198154; 12220669; 12235128; 12477932; 12482751; 12496482; 12499380; 12604344; 12684039; 12702723; 12702765; 12721308; 12753742; 12761501; 12796506; 12815462; 12851487; 12887920; 12911633; 12954630; 14573612; 14644197; 14694156; 15034549; 15048887; 15069192; 15173180; 15207703; 15280356; 15383280; 15388581; 15452117; 15452120; 15485835; 15489334; 15601308; 15645452; 15659383; 15665818; 15688372; 15761471; 15778222; 15782135; 15849201; 15916534; 15956881; 16003390; 16006552; 16061179; 16109772; 16127453; 16169070; 16177127; 16227629; 16258269; 16289096; 16339514; 16360037; 16410793; 16450001; 16498403; 16528386; 16538383; 16611992; 16710361; 16762833; 16844082; 16871589; 16937440; 17031492; 17047155; 17159907; 17235653; 17290218; 17360386; 17511679; 17656375; 17911615; 17975136; 17977957; 18029348; 18174230; 18309324; 18328427; 18387192; 18485876; 18632871; 18632964; 18813792; 18840411; 19060883; 19074885; 19118384; 19125371; 19176810; 19303913; 19336038; 19362094; 19364499; 19373245; 19415536; 19453261; 19524513; 19557578; 19573080; 19583773; 19593445; 19773279; 19955841; 20040024; 20070122; 20353946; 20420860; 20438666; 20448643; 20484047; 20568250; 20588308; 20802294; 20890306; 20935634; 20943999; 20947025; 21048031; 21052097; 21109225; 21115735; 21183682; 21315423; 21382479; 21458669; 21525013; 21613217; 21620750; 21706480; 21724995; 21737329; 21785459; 21803845; 21822306; 21894190; 21900206; 219789…
description: Fas (TNFRSF6)-associated via death domain
database cross reference: Ensembl:ENSG00000168040
database cross reference: HGNC:3573
database cross reference: HPRD:03909
database cross reference: MIM:602457
database cross reference: Vega:OTTHUMG00000167264

PSPHP1
type: Class
subclass of: pseudo gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CO9
alternative term: PSPHL
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PSPHP1
full name from nomenclature authority: phosphoserine phosphatase pseudogene 1
NCBI GeneID: 8781
gene map location: 7q11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: pseudo
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004647 (EC: TAS, PMID: 9573387); GO_0008283 (EC: TAS, PMID: 9573387); GO_0016311 (EC: TAS, PMID: 9573387)
has PubMed association: PMID: 9573387; 12477932
description: phosphoserine phosphatase pseudogene 1
database cross reference: HGNC:9578
database cross reference: MIM:604239

TNFRSF10C
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD263
alternative term: DCR1
alternative term: DCR1-TNFR
alternative term: LIT
alternative term: TRAIL-R3
alternative term: TRAILR3
alternative term: TRID
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TNFRSF10C
full name from nomenclature authority: tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
NCBI GeneID: 8794
NCBI LocusTag: UNQ321/PRO366
gene map location: 8p22-p21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004888 (EC: TAS, PMID: 9314565); GO_0005887 (EC: TAS, PMID: 9314565); GO_0006915 (EC: IEA); GO_0007165 (EC: TAS, PMID: 9314565); GO_0031225 (EC: IEA); GO_0045569 (EC: IEA)
has PubMed association: PMID: 9242610; 9242611; 9314565; 9325248; 9373179; 9551946; 9613612; 10435597; 11001921; 11024459; 11396170; 11417478; 11420819; 11442750; 11451151; 11464279; 11753607; 11844843; 11848467; 11859410; 12136286; 12390973; 12417331; 12477932; 12488957; 12808117; 12975309; 14623878; 14999791; 15207703; 15301860; 15340161; 15489334; 15538968; 15916713; 15921376; 15990565; 16046522; 16169070; 16174727; 16980609; 17522430; 17690453; 18345033; 18460741; 18511705; 18590575; 19035483; 19573080; 19661294; 19773279; 19936781; 20237496; 20451496; 20568250; 20799941; 21281967; 21483669; 22555108; 23320456; 23602568; 24211571
description: tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
database cross reference: Ensembl:ENSG00000173535
database cross reference: HGNC:11906
database cross reference: HPRD:04681
database cross reference: MIM:603613
database cross reference: Vega:OTTHUMG00000097844

GALR2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GAL2-R
alternative term: GALNR2
alternative term: GALR-2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GALR2
full name from nomenclature authority: galanin receptor 2
NCBI GeneID: 8811
gene map location: 17q25.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004966 (EC: IEA); GO_0005515 (EC: IPI); GO_0005886 (EC: TAS); GO_0006936 (EC: TAS, PMID: 9480833); GO_0007166 (EC: TAS, PMID: 9480833); GO_0007188 (EC: TAS, PMID: 9685625); GO_0007194 (EC: IEA); GO_0007204 (EC: IEA); GO_0007218 (EC: TAS, PMID: 9480833); GO_0007268 (EC: TAS, PMID: 9832121); GO_0007275 (EC: TAS, PMID: 9480833); GO_0007586 (EC: TAS, PMID: 9832121); GO_0007611 (EC: TAS, PMID: 9480833); GO_0007631 (EC: TAS, PMID: 9480833); GO_0016021 (EC: IEA); GO_0031175 (EC: IEA)
has PubMed association: PMID: 2834384; 9480833; 9685625; 9832121; 9880084; 11867941; 12477932; 14592962; 15489334; 17083333; 18272487; 18577758; 19086053; 21345369; 21850381; 21894515; 22329353; 22889491; 23237663; 23278944; 23341594; 24122450
description: galanin receptor 2
database cross reference: Ensembl:ENSG00000182687
database cross reference: HGNC:4133
database cross reference: HPRD:04735
database cross reference: MIM:603691
database cross reference: Vega:OTTHUMG00000167479

HESX1
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ANF
alternative term: CPHD5
alternative term: RPX
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HESX1
full name from nomenclature authority: HESX homeobox 1
NCBI GeneID: 8820
gene map location: 3p14.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003677 (EC: TAS, PMID: 9620767); GO_0003682 (EC: IEA); GO_0003700 (EC: IEA); GO_0005515 (EC: IPI); GO_0005634 (EC: IEA); GO_0006351 (EC: IEA); GO_0007420 (EC: TAS, PMID: 9620767); GO_0008022 (EC: IEA); GO_0030916 (EC: IEA); GO_0043565 (EC: IEA); GO_0043584 (EC: IEA); GO_0045892 (EC: IEA); GO_0047485 (EC: IEA); GO_0048853 (EC: IEA)
has PubMed association: PMID: 7876132; 8696006; 9373136; 9620767; 9751061; 11136712; 11283314; 11731482; 11748154; 12063185; 12424431; 12477932; 12519827; 14557462; 14561704; 14646405; 14714741; 15489334; 16424673; 16940453; 17148560; 17587179; 17931718; 18728160; 19561080; 20181723; 20211142; 20534763; 20694410; 20949537; 21270112; 21325470; 21761366; 23199197; 23455924; 23465708
description: HESX homeobox 1
database cross reference: HGNC:4877
database cross reference: HPRD:03482
database cross reference: MIM:601802

WISP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CCN4
alternative term: WISP1c
alternative term: WISP1i
alternative term: WISP1tc
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: WISP1
full name from nomenclature authority: WNT1 inducible signaling pathway protein 1
NCBI GeneID: 8840
gene map location: 8q24.22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001558 (EC: IEA); GO_0005520 (EC: IEA); GO_0005615 (EC: NAS, PMID: 9843955); GO_0005737 (EC: IDA); GO_0007155 (EC: IEA); GO_0007165 (EC: TAS, PMID: 9843955); GO_0007267 (EC: TAS, PMID: 9843955); GO_0016055 (EC: IEA)
has PubMed association: PMID: 9843955; 10716946; 11571650; 11598131; 11751417; 11782444; 11855747; 12477932; 12529380; 12717393; 12805222; 15489334; 15650268; 16421571; 17353931; 17381509; 17406949; 17579708; 17593496; 17657846; 18006828; 18029348; 18404666; 18701807; 19069651; 19180479; 19238344; 19240061; 19282865; 19287097; 19339243; 19453261; 19926868; 20010302; 20074638; 20372786; 20379614; 20403915; 20506641; 20628624; 20677014; 20684029; 21109017; 21321938; 21453685; 21498727; 21516124; 22778029; 22873724; 23300278; 23313051; 23316072; 23612905
description: WNT1 inducible signaling pathway protein 1
database cross reference: HGNC:12769
database cross reference: HPRD:16019
database cross reference: MIM:603398

CDK5R1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CDK5P35
alternative term: CDK5R
alternative term: NCK5A
alternative term: p23
alternative term: p25
alternative term: p35
alternative term: p35nck5a
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CDK5R1
full name from nomenclature authority: cyclin-dependent kinase 5, regulatory subunit 1 (p35)
NCBI GeneID: 8851
gene map location: 17q11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000079 (EC: TAS, PMID: 7592934); GO_0001764 (EC: ISS); GO_0004672 (EC: TAS, PMID: 7592934); GO_0004693 (EC: IEA); GO_0005509 (EC: ISS); GO_0005515 (EC: IPI, PMID: 10721722); GO_0005634 (EC: ISS); GO_0005737 (EC: ISS); GO_0005829 (EC: TAS); GO_0005886 (EC: IEA); GO_0007158 (EC: ISS); GO_0007213 (EC: ISS); GO_0007411 (EC: ISS); GO_0007411 (EC: TAS); GO_0007413 (EC: ISS); GO_0007420 (EC: ISS); GO_0007420 (EC: NAS, PMID: 10915792); GO_0008283 (EC: TAS, PMID: 8090221); GO_0009790 (EC: ISS); GO_0014069 (EC: ISS); GO_0016020 (EC: ISS); GO_0016301 (EC: ISS); GO_0016533 (EC: IEA); GO_0016534 (EC: IEA); GO_0018105 (EC: IDA, PMID: 12832520); GO_0018107 (EC: IDA, PMID: 12832520); GO_0019901 (EC: IPI, PMID: 12832520); GO_0021549 (EC: IEA); GO_0021722 (EC: IEA); GO_0021766 (EC: IEA); GO_0021819 (EC: IEA); GO_0030182 (EC: ISS); GO_0030424 (EC: ISS); GO_0030425 (EC: ISS); GO_0030426 (EC: ISS); GO_0030517 (EC: IEA); GO_0031175 (EC: ISS); GO_0031594 (EC: ISS); GO_0032956 (EC: IEA); GO_0033136 (EC: IEA); GO_0035235 (EC: ISS); GO_0043025 (EC: ISS); GO_0043197 (EC: ISS); GO_0043292 (EC: ISS); GO_0043525 (EC: ISS); GO_0043539 (EC: IDA, PMID: 12832520); GO_0043539 (EC: ISS); GO_0045296 (EC: ISS); GO_0045664 (EC: NAS, PMID: 10721722); GO_0045892 (EC: IMP); GO_0046875 (EC: IEA); GO_0048013 (EC: ISS); GO_0048471 (EC: IDA, PMID: 12832520); GO_0061001 (EC: ISS); GO_0070507 (EC: IEA); GO_0090314 (EC: IEA)
has PubMed association: PMID: 7556643; 7592934; 8090221; 9010203; 9038181; 9933594; 10604467; 10721722; 10753743; 10830966; 10915792; 11113134; 11168528; 11389014; 11583627; 11604394; 11741927; 11784720; 11882646; 12037672; 12084709; 12223541; 12226093; 12230554; 12477932; 12491158; 12688339; 12826674; 12832492; 12832520; 12859671; 14521924; 14702039; 14976144; 15013773; 15123618; 15175076; 15342635; 15489224; 15489334; 15492003; 15536496; 15689152; 15741232; 15917097; 16189514; 16407256; 16425041; 16678793; 17036052; 17060323; 17121855; 17207965; 17491008; 17493033; 17496813; 17591690; 17762160; 18053171; 18247371; 18325333; 18829967; 19081376; 19154537; 19638632; 19874574; 19913121; 19953087; 20097924; 20354813; 20518484; 20618441; 20628086; 21130530; 21220307; 21544067; 21625387; 21772061; 21832049; 22654103; 22964075; 23151508; 23455922; 23602568; 24085300
description: cyclin-dependent kinase 5, regulatory subunit 1 (p35)
database cross reference: Ensembl:ENSG00000176749
database cross reference: HGNC:1775
database cross reference: HPRD:04586
database cross reference: MIM:603460
database cross reference: Vega:OTTHUMG00000132814

SPHK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SPHK
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SPHK1
full name from nomenclature authority: sphingosine kinase 1
NCBI GeneID: 8877
gene map location: 17q25.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000287 (EC: IDA, PMID: 10947957); GO_0000287 (EC: ISS); GO_0001568 (EC: IEA); GO_0001934 (EC: IEA); GO_0001956 (EC: IEA); GO_0003677 (EC: IDA, PMID: 12393916); GO_0003951 (EC: IEA); GO_0004143 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12080051); GO_0005516 (EC: IDA, PMID: 10947957); GO_0005524 (EC: IDA, PMID: 12393916); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS, PMID: 10863092); GO_0005886 (EC: IDA); GO_0006457 (EC: TAS); GO_0006665 (EC: TAS); GO_0006670 (EC: IDA); GO_0006954 (EC: IEA); GO_0007165 (EC: TAS, PMID: 10751414); GO_0007205 (EC: IEA); GO_0007420 (EC: IEA); GO_0007565 (EC: IEA); GO_0008021 (EC: IEA); GO_0008481 (EC: IDA, PMID: 12393916); GO_0009267 (EC: IEA); GO_0010803 (EC: IDA); GO_0010976 (EC: IEA); GO_0014075 (EC: IEA); GO_0017050 (EC: IDA, PMID: 10863092); GO_0019371 (EC: IEA); GO_0019722 (EC: IDA, PMID: 10947957); GO_0030148 (EC: TAS); GO_0030307 (EC: IDA, PMID: 12441135); GO_0030335 (EC: IDA, PMID: 12441135); GO_0030424 (EC: IEA); GO_0031398 (EC: IDA); GO_0032026 (EC: IEA); GO_0032570 (EC: IEA); GO_0032651 (EC: IEA); GO_0033198 (EC: IEA); GO_0035556 (EC: TAS, PMID: 10947957); GO_0042346 (EC: IMP); GO_0043066 (EC: IDA, PMID: 15623571); GO_0043066 (EC: TAS, PMID: 10947957); GO_0044267 (EC: TAS); GO_0044281 (EC: TAS); GO_0045766 (EC: IDA, PMID: 12441135); GO_0045931 (EC: IDA, PMID: 12441135); GO_0045987 (EC: IDA, PMID: 12847068); GO_0046521 (EC: NAS, PMID: 10863092); GO_0046834 (EC: IDA, PMID: 12393916); GO_0048146 (EC: IDA, PMID: 15623571); GO_0051084 (EC: TAS); GO_0051092 (EC: IMP); GO_0051721 (EC: IPI); GO_0070301 (EC: IEA); GO_0070555 (EC: IEA); GO_0071363 (EC: IEA)
has PubMed association: PMID: 7698749; 8125298; 8889549; 9726979; 10751414; 10802064; 10863092; 10947957; 11777919; 11915350; 12077123; 12080051; 12124383; 12393916; 12441135; 12444147; 12477932; 12847068; 14532121; 14575709; 14702039; 14742298; 14988393; 15052627; 15191888; 15193146; 15265705; 15302883; 15342556; 15585953; 15623571; 15632208; 15693752; 15710602; 15749892; 15855330; 16038795; 16194537; 16243846; 16316995; 16507765; 16516161; 16529909; 16571380; 16623665; 16888242; 17064696; 17114809; 17124500; 17388800; 17482291; 17519232; 17599053; 17641298; 17822721; 18058224; 18178871; 18192241; 18199826; 18261991; 18263879; 18362204; 18401414; 18426913; 18644866; 18718048; 18775504; 18824518; 18849324; 18852266; 18922940; 18980995; 19017993; 19074142; 19116345; 19162217; 19238330; 19240026; 19633297; 19657322; 19706837; 19782042; 19815712; 19830907; 19854831; 19914200; 19956567; 20053797; 20104488; 20237496; 20386061; 20404323; 20519401; 20520628; 20606403; 20634980; 20661259; 20838377; 20846391; 20889557; 20926375; 21075134; 21075214; 21139048; 21209394; 21304987; 21392092; 21418911; 21464128; 21575515; 21625639; 21672077; 21696364; 21756066; 21769916; 21936950; 21940753; 21988832; 22016563; 22155656; 22227192; 22315056; 22322056; 22322303; 22331716; 22422617; 22450659; 22460268; 22684547; 22733311; 22781898; 22833671; 22961081; 23166225; 23232649; 23314175; 23359503; 23426175; 23462226; 23466305; 23576579; 23602659; 23651497; 23658376; 23839903; 23861887; 23928990; 23939980; 23955546
description: sphingosine kinase 1
database cross reference: Ensembl:ENSG00000176170
database cross reference: HGNC:11240
database cross reference: HPRD:04768
database cross reference: MIM:603730
database cross reference: Vega:OTTHUMG00000180177

BTRC
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BETA-TRCP
alternative term: FBW1A
alternative term: FBXW1
alternative term: FBXW1A
alternative term: FWD1
alternative term: bTrCP
alternative term: bTrCP1
alternative term: betaTrCP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BTRC
full name from nomenclature authority: beta-transducin repeat containing E3 ubiquitin protein ligase
NCBI GeneID: 8945
NCBI LocusTag: RP11-529I10.2
gene map location: 10q24.32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000086 (EC: TAS); GO_0000209 (EC: IEA); GO_0000278 (EC: TAS); GO_0004842 (EC: IDA, Qualifier: contributes_to, PMID: 15448698); GO_0005515 (EC: IPI, PMID: 11238952); GO_0005634 (EC: IEA); GO_0005829 (EC: TAS); GO_0006470 (EC: IEA); GO_0006511 (EC: IDA, PMID: 15448698); GO_0007165 (EC: TAS, PMID: 9990853); GO_0008013 (EC: IEA); GO_0016032 (EC: TAS); GO_0016055 (EC: IEA); GO_0016567 (EC: IDA, PMID: 16885022); GO_0019005 (EC: IDA, PMID: 19966869); GO_0031145 (EC: TAS); GO_0031146 (EC: IBA); GO_0031648 (EC: IMP, PMID: 16885022); GO_0033598 (EC: IEA); GO_0042753 (EC: IEA); GO_0043122 (EC: IEA); GO_0043433 (EC: TAS, PMID: 11001584); GO_0045309 (EC: IEA); GO_0045862 (EC: IMP, PMID: 16885022); GO_0045879 (EC: TAS, PMID: 11001584); GO_0045892 (EC: IMP, PMID: 19966869); GO_0045893 (EC: IEA); GO_0046983 (EC: IEA); GO_0051437 (EC: TAS); GO_0051439 (EC: TAS); GO_0051726 (EC: IEA); GO_0060444 (EC: IEA); GO_0061136 (EC: IEA); GO_0071407 (EC: IEA)
has PubMed association: PMID: 8889548; 9660940; 9859996; 9990852; 9990853; 10023660; 10066435; 10072378; 10074433; 10075690; 10228155; 10331953; 10514424; 10514433; 10531035; 10564661; 10644755; 10713156; 10803460; 10828603; 10835356; 10918611; 10983987; 11001584; 11027288; 11158290; 11238952; 11278695; 11359933; 11483504; 11696595; 11818547; 11850407; 11953428; 11994270; 12037680; 12077367; 12114015; 12124804; 12151397; 12417018; 12477932; 12482991; 12504025; 12609982; 12684064; 12791267; 12820959; 12902344; 14516475; 14526201; 14561767; 14603323; 14673179; 14674748; 14676825; 14681206; 14706645; 14743216; 14752276; 14988407; 15070733; 15140882; 15314162; 15340078; 15448698; 15469984; 15485837; 15489334; 15647282; 15735746; 15743413; 15782160; 15798217; 15845771; 15855639; 15917222; 15927956; 15966899; 16165251; 16189514; 16196087; 16219772; 16275325; 16278670; 16303288; 16338364; 16344560; 16354571; 16371461; 16385451; 16651270; 16691619; 16705181; 16757476; 16778892; 16798748; 16865698; 16885021; 16885022; 17053147; 17079684; 17121803; 17213322; 17215248; 17217622; 17283138; 17295679; 17318178; 17319651; 17327410; 17387146; 17445772; 17463251; 17491012; 17500058; 17510365; 17586316; 17676996; 17937819; 17939994; 17965458; 18052253; 18056411; 18296647; 18316598; 18354482; 18354483; 18363964; 18372914; 18378770; 18460583; 18521620; 18541215; 18575781; 18617892; 18650423; 18662541; 18672082; 18765672; 18794143; 18851830; 19053519; 19061640; 19106159; 19150432; 19159283; 19196987; 19240029; 19240121; 19244337; 19297328; 19372209; 19411070; 19477924; 19478868; 19515779; 19557001; 19615732; 19647520; 19656241; 19730691; 19797085; 19822658; 19931512; 19933270; 19944437; 19955572; 19966869; 20048001; 20068069; 20102634; 20140206; 20201792; 20348946; 20353940; 20378537; 20379614; 20442859; 20503246; 20516151; 20531388; 20558726; 20625400; 20638939; 20708156; 20736409; 20797629; 20844743; 20852628; 20858893; 20980512; 21051950; 21070969; 21138764; 21139048; 21145461; 21173164; 21189257; 21249194;…
description: beta-transducin repeat containing E3 ubiquitin protein ligase
database cross reference: Ensembl:ENSG00000166167
database cross reference: HGNC:1144
database cross reference: HPRD:04596
database cross reference: MIM:603482
database cross reference: Vega:OTTHUMG00000018932

CH25H
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: C25H
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CH25H
full name from nomenclature authority: cholesterol 25-hydroxylase
NCBI GeneID: 9023
gene map location: 10q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001567 (EC: IEA); GO_0005506 (EC: IEA); GO_0005789 (EC: IEA); GO_0005829 (EC: TAS); GO_0006629 (EC: TAS, PMID: 9852097); GO_0006633 (EC: IEA); GO_0006699 (EC: TAS); GO_0008203 (EC: IEA); GO_0008206 (EC: TAS); GO_0008395 (EC: TAS); GO_0016021 (EC: IEA); GO_0016126 (EC: IEA); GO_0044281 (EC: TAS)
has PubMed association: PMID: 9852097; 12477932; 15164054; 15465627; 15489334; 16157450; 16385451; 16909003; 17373700; 18830724; 20413850; 20445134; 20534741; 20535486; 20574532; 20699362; 21041692
description: cholesterol 25-hydroxylase
database cross reference: Ensembl:ENSG00000138135
database cross reference: HGNC:1907
database cross reference: HPRD:05183
database cross reference: MIM:604551
database cross reference: Vega:OTTHUMG00000018705

UBA3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NAE2
alternative term: UBE1C
alternative term: hUBA3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: UBA3
full name from nomenclature authority: ubiquitin-like modifier activating enzyme 3
NCBI GeneID: 9039
gene map location: 3p14.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 10722740); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0006464 (EC: TAS, PMID: 9694792); GO_0006508 (EC: TAS, PMID: 9694792); GO_0007113 (EC: IEA); GO_0008641 (EC: IEA); GO_0016881 (EC: IEA); GO_0045116 (EC: IEA); GO_0046982 (EC: IPI, PMID: 12740388); GO_0051726 (EC: IEA)
has PubMed association: PMID: 9694792; 10207026; 10409428; 10722740; 11076863; 11230166; 11256614; 12477932; 12646924; 12740388; 14690597; 14702039; 15361859; 15489334; 15489336; 15694336; 16169070; 16381901; 16400609; 16503656; 16620772; 17220875; 17353931; 18264111; 18652489; 19250909; 19549727; 19615732; 21139048; 21145461; 21890473; 21906983; 21963094; 22404213; 22505724; 22821745; 22863883; 22939629; 23000965; 23455924
description: ubiquitin-like modifier activating enzyme 3
database cross reference: Ensembl:ENSG00000144744
database cross reference: HGNC:12470
database cross reference: HPRD:04413
database cross reference: MIM:603172
database cross reference: Vega:OTTHUMG00000154325

UBE2M
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: UBC-RS2
alternative term: UBC12
alternative term: hUbc12
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: UBE2M
full name from nomenclature authority: ubiquitin-conjugating enzyme E2M
NCBI GeneID: 9040
gene map location: 19q13.43
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004842 (EC: IMP, PMID: 15694336); GO_0004842 (EC: TAS, PMID: 9694792); GO_0005515 (EC: IPI, PMID: 15361859); GO_0005524 (EC: IEA); GO_0005575 (EC: ND); GO_0005829 (EC: TAS); GO_0006464 (EC: IMP, PMID: 15694336); GO_0006464 (EC: TAS, PMID: 9694792); GO_0007179 (EC: TAS); GO_0016567 (EC: IMP, PMID: 15694336); GO_0016567 (EC: TAS, PMID: 9694792); GO_0018169 (EC: IDA, PMID: 15361859); GO_0019788 (EC: IDA, PMID: 19250909); GO_0043525 (EC: IEA); GO_0045116 (EC: IDA, PMID: 19250909); GO_0045116 (EC: IEA)
has PubMed association: PMID: 9694792; 10207026; 10722740; 10828074; 11574546; 12477932; 12522145; 12565873; 15242646; 15361859; 15489334; 15694336; 16275327; 16341674; 16503656; 16620772; 16735510; 17220875; 17353931; 17643375; 18096514; 18274552; 18652489; 18826954; 19245792; 19250909; 19549727; 19738201; 19953087; 20353940; 21139048; 21145461; 21247897; 21477582; 21765416; 21832049; 21853274; 21890473; 21906983; 21940857; 21946088; 21963094; 21987584; 22388932; 22412018; 22505724; 22623428; 22797925; 22939629; 23000965; 23201271; 23267066; 23383273; 23936405; 24192928; 24250222
description: ubiquitin-conjugating enzyme E2M
database cross reference: Ensembl:ENSG00000130725
database cross reference: HGNC:12491
database cross reference: HPRD:04414
database cross reference: MIM:603173
database cross reference: Vega:OTTHUMG00000183548

ATG12
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APG12
alternative term: APG12L
alternative term: FBR93
alternative term: HAPG12
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ATG12
full name from nomenclature authority: autophagy related 12
NCBI GeneID: 9140
gene map location: 5q21-q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000045 (EC: ISS); GO_0005515 (EC: IPI, PMID: 11096062); GO_0032480 (EC: TAS); GO_0034045 (EC: ISS); GO_0043234 (EC: IEA); GO_0045087 (EC: TAS)
has PubMed association: PMID: 8889548; 9490301; 9852036; 11096062; 11825910; 11890701; 12207896; 12477932; 12482611; 12665549; 14702039; 15146197; 15342556; 15489334; 16189514; 16344560; 17353931; 17457038; 18187620; 19124466; 19197948; 19901552; 20417604; 20562859; 20723759; 21139048; 21832049; 21906983; 22152474; 22170153; 22342342; 23202584; 23307622
description: autophagy related 12
database cross reference: Ensembl:ENSG00000145782
database cross reference: HGNC:588
database cross reference: HPRD:08496
database cross reference: MIM:609608
database cross reference: Vega:OTTHUMG00000128889

ITM2B
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ABRI
alternative term: BRI
alternative term: BRI2
alternative term: BRICD2B
alternative term: E25B
alternative term: E3-16
alternative term: FBD
alternative term: imBRI2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ITM2B
full name from nomenclature authority: integral membrane protein 2B
NCBI GeneID: 9445
NCBI LocusTag: RP11-196P14.1
gene map location: 13q14.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 13
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001540 (EC: IPI, PMID: 19849849); GO_0005515 (EC: IPI, PMID: 16027166); GO_0005524 (EC: IEA); GO_0005576 (EC: TAS); GO_0005615 (EC: IDA, PMID: 18524908); GO_0005794 (EC: IDA); GO_0005886 (EC: IDA, PMID: 19114711); GO_0007399 (EC: TAS, PMID: 10391242); GO_0010008 (EC: IEA); GO_0030660 (EC: IDA, PMID: 17965014); GO_0031301 (EC: IDA, PMID: 10526337); GO_0042985 (EC: IDA, PMID: 16027166); GO_0043231 (EC: IDA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0097192 (EC: IEA)
has PubMed association: PMID: 5466275; 9795190; 10391242; 10526337; 10781099; 10931946; 12082633; 12196136; 12477932; 12903036; 14586629; 14656991; 15489334; 15968464; 15983050; 16027166; 16344560; 16612984; 17965014; 18029348; 18282158; 18440095; 18524908; 19056867; 19072909; 19114711; 19366692; 19748705; 19849849; 20036644; 20600910; 20972266; 21048150; 21139048; 21587206; 21752865; 21841249; 21873424; 21875946; 21890473; 21906983; 21963094; 22053931; 22190034; 22194595; 22505724; 23000965; 23261769; 23418567; 23701002; 24099305
description: integral membrane protein 2B
database cross reference: Ensembl:ENSG00000136156
database cross reference: HGNC:6174
database cross reference: HPRD:04878
database cross reference: MIM:603904
database cross reference: Vega:OTTHUMG00000016894

GSTO1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GSTO 1-1
alternative term: GSTTLp28
alternative term: HEL-S-21
alternative term: P28
alternative term: SPG-R
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GSTO1
full name from nomenclature authority: glutathione S-transferase omega 1
NCBI GeneID: 9446
NCBI LocusTag: RP11-99N20.1
gene map location: 10q25.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004364 (EC: IDA, PMID: 11511179); GO_0005737 (EC: IDA, PMID: 11511179); GO_0005829 (EC: TAS); GO_0006805 (EC: TAS); GO_0010880 (EC: IDA, PMID: 11035031); GO_0010881 (EC: IC, PMID: 11035031); GO_0014810 (EC: IC, PMID: 11035031); GO_0016491 (EC: IDA, PMID: 11511179); GO_0019852 (EC: IDA, PMID: 11511179); GO_0042178 (EC: IDA, PMID: 12928150); GO_0044281 (EC: TAS); GO_0045174 (EC: IDA, PMID: 11511179); GO_0050610 (EC: IEA); GO_0060315 (EC: IDA, PMID: 11035031); GO_0060316 (EC: IDA, PMID: 11035031); GO_0070062 (EC: IDA, PMID: 19056867); GO_0071243 (EC: IDA, PMID: 11511179); GO_1901687 (EC: TAS)
has PubMed association: PMID: 8076819; 8889548; 9786866; 9988762; 10783391; 11035031; 11271497; 11457926; 11511179; 12477932; 12565892; 12618591; 12928150; 14570706; 15040808; 15146197; 15159516; 15164054; 15489334; 15623683; 15901998; 15917099; 15992993; 16169070; 16385451; 17158763; 17194543; 17213182; 17450230; 17484623; 17548696; 17601350; 17617905; 17637926; 17717316; 18065725; 18186040; 18216717; 18400112; 18414193; 18414634; 18427999; 18449862; 18571971; 18720901; 18799873; 18941778; 18977241; 18986335; 19056867; 19148497; 19152805; 19513904; 19624857; 19635583; 19686770; 19738201; 19859803; 19913121; 19914269; 20106899; 20113212; 20200426; 20210239; 20237496; 20367187; 20374258; 20472488; 20532380; 20547570; 20562859; 20628086; 20670920; 20800603; 20818931; 21094982; 21106529; 21139048; 21351650; 21832049; 21890473; 21906983; 21963094; 22100662; 22283150; 22293942; 22339537; 22440634; 22494505; 22505724; 22522127; 22747749; 22939629; 23000965; 23086268; 23824909; 23888047
description: glutathione S-transferase omega 1
database cross reference: Ensembl:ENSG00000148834
database cross reference: HGNC:13312
database cross reference: HPRD:10401
database cross reference: MIM:605482
database cross reference: Vega:OTTHUMG00000019001

EIF2AK3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PEK
alternative term: PERK
alternative term: WRS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: EIF2AK3
full name from nomenclature authority: eukaryotic translation initiation factor 2-alpha kinase 3
NCBI GeneID: 9451
gene map location: 2p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001501 (EC: ISS); GO_0001503 (EC: IMP, PMID: 12086964); GO_0002063 (EC: ISS); GO_0004672 (EC: TAS, PMID: 10026192); GO_0004674 (EC: ISS); GO_0004674 (EC: TAS); GO_0004694 (EC: IDA, PMID: 10026192); GO_0004694 (EC: IMP, PMID: 12086964); GO_0005515 (EC: IPI, PMID: 11907036); GO_0005524 (EC: IEA); GO_0005737 (EC: ISS); GO_0005783 (EC: IC, PMID: 11907036); GO_0005783 (EC: ISS); GO_0005783 (EC: TAS, PMID: 12086964); GO_0005789 (EC: ISS); GO_0005789 (EC: NAS, PMID: 11907036); GO_0005789 (EC: TAS); GO_0006412 (EC: IEA); GO_0006468 (EC: ISS); GO_0006919 (EC: ISS); GO_0006983 (EC: IDA, PMID: 10677345); GO_0006987 (EC: TAS); GO_0007029 (EC: ISS); GO_0007595 (EC: IEA); GO_0009967 (EC: IEA); GO_0016021 (EC: IEA); GO_0017148 (EC: TAS, PMID: 12086964); GO_0019217 (EC: IEA); GO_0019722 (EC: ISS); GO_0019899 (EC: IPI); GO_0019903 (EC: IPI); GO_0030073 (EC: ISS); GO_0030282 (EC: ISS); GO_0030968 (EC: IDA, PMID: 10677345); GO_0030968 (EC: TAS, PMID: 19816510); GO_0031018 (EC: IMP, PMID: 12086964); GO_0031642 (EC: ISS); GO_0032057 (EC: TAS, PMID: 10677345); GO_0032092 (EC: IEA); GO_0032933 (EC: IEA); GO_0034976 (EC: IMP, PMID: 19061639); GO_0042802 (EC: IPI, PMID: 11907036); GO_0044267 (EC: TAS); GO_0045444 (EC: IEA); GO_0046777 (EC: IDA, PMID: 10026192); GO_0046777 (EC: IMP, PMID: 12086964); GO_0048009 (EC: ISS); GO_0051260 (EC: IMP, PMID: 11907036); GO_0070059 (EC: IEA)
has PubMed association: PMID: 1677563; 8099443; 9819435; 10026192; 10542257; 10575235; 10677345; 10848580; 10932183; 11555640; 11907036; 12014989; 12086964; 12370288; 12446770; 12446838; 12477932; 12610133; 14517290; 15146197; 15220213; 15234121; 15483661; 15489334; 15650164; 16147992; 16148948; 16288713; 16344560; 16720581; 17229688; 17785458; 17823375; 18063576; 18216498; 18426796; 18451152; 18664456; 18787411; 19009018; 19029953; 19061639; 19586904; 19816510; 19837917; 19913121; 20072656; 20103619; 20202148; 20348950; 20371724; 20379614; 20457808; 20463975; 20628086; 20709135; 20800603; 20881960; 21385877; 21419175; 21464971; 21518408; 21648287; 21685912; 21709020; 22028037; 22072062; 22169477; 22246806; 22253692; 22354021; 22446326; 22795130; 22813743; 22915762; 22917505; 22956602; 23103912; 23110043; 23116876; 23160380; 23471998; 23585173; 23592989; 23759358; 24103755; 24114838; 24457600
description: eukaryotic translation initiation factor 2-alpha kinase 3
database cross reference: Ensembl:ENSG00000172071
database cross reference: HGNC:3255
database cross reference: HPRD:04942
database cross reference: MIM:604032
database cross reference: Vega:OTTHUMG00000155046

GGPS1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GGPPS
alternative term: GGPPS1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GGPS1
full name from nomenclature authority: geranylgeranyl diphosphate synthase 1
NCBI GeneID: 9453
gene map location: 1q43
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004161 (EC: IEA); GO_0004311 (EC: IDA, PMID: 10026212); GO_0004337 (EC: IEA); GO_0005829 (EC: TAS); GO_0006695 (EC: TAS); GO_0006720 (EC: IDA, PMID: 10026212); GO_0033384 (EC: IEA); GO_0033386 (EC: IEA); GO_0044281 (EC: TAS); GO_0045337 (EC: IEA); GO_0046872 (EC: IEA)
has PubMed association: PMID: 8419360; 9741684; 10026212; 10101267; 10931946; 12446740; 12477932; 15489334; 16698791; 16710414; 16806233; 17207965; 17536018; 17646172; 18726356; 20191015; 21139048; 21224049; 21321112; 21890473; 21906983; 22505724; 23478574
description: geranylgeranyl diphosphate synthase 1
database cross reference: Ensembl:ENSG00000152904
database cross reference: HGNC:4249
database cross reference: HPRD:06099
database cross reference: MIM:606982
database cross reference: Vega:OTTHUMG00000037963

ATG5
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APG5
alternative term: APG5-LIKE
alternative term: APG5L
alternative term: ASP
alternative term: hAPG5
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ATG5
full name from nomenclature authority: autophagy related 5
NCBI GeneID: 9474
gene map location: 6q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000045 (EC: ISS); GO_0001974 (EC: IEA); GO_0002739 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11096062); GO_0005737 (EC: ISS); GO_0005776 (EC: IDA, PMID: 15292400); GO_0005930 (EC: ISS); GO_0006914 (EC: ISS); GO_0006915 (EC: IEA); GO_0009620 (EC: IEA); GO_0031397 (EC: IEA); GO_0032480 (EC: TAS); GO_0034045 (EC: ISS); GO_0042311 (EC: IEA); GO_0042493 (EC: IEA); GO_0043066 (EC: IEA); GO_0043687 (EC: ISS); GO_0045087 (EC: TAS); GO_0048840 (EC: IEA); GO_0055015 (EC: IEA); GO_0060047 (EC: IEA); GO_1902017 (EC: ISS)
has PubMed association: PMID: 7796880; 9563500; 9852036; 10702672; 11096062; 11266458; 11349150; 11725643; 11825910; 12207896; 12417306; 12477932; 12482611; 12665549; 12703993; 14574404; 14702039; 15292400; 15342556; 15489334; 15778222; 16341674; 17207965; 17353931; 18296641; 18353420; 18448665; 19066443; 19124466; 19148225; 19194464; 19197948; 19322201; 19375507; 19783847; 19838193; 19881538; 19901552; 20038797; 20190558; 20379614; 20417604; 20529838; 20562859; 20580051; 20639872; 20697744; 20962850; 21068098; 21139048; 21622776; 21655094; 21664058; 21722286; 21795849; 21906983; 21976705; 21995634; 22040493; 22052905; 22170153; 22342342; 22536318; 22863883; 22993366; 23075929; 23202584; 23235332; 23242420; 23273568; 23317196; 23322078; 23384565; 23429496; 23486359; 23740937; 24250222; 24269628; 24324106
description: autophagy related 5
database cross reference: Ensembl:ENSG00000057663
database cross reference: HGNC:589
database cross reference: HPRD:16051
database cross reference: MIM:604261
database cross reference: Vega:OTTHUMG00000016193

MAPK8IP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IB1
alternative term: JIP-1
alternative term: JIP1
alternative term: PRKM8IP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MAPK8IP1
full name from nomenclature authority: mitogen-activated protein kinase 8 interacting protein 1
NCBI GeneID: 9479
gene map location: 11p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004860 (EC: TAS, PMID: 9933567); GO_0005078 (EC: IPI, PMID: 11238452); GO_0005515 (EC: IPI, PMID: 11517249); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA, PMID: 10574993); GO_0005789 (EC: IEA); GO_0005829 (EC: IEA); GO_0006355 (EC: IEA); GO_0007258 (EC: IEA); GO_0008432 (EC: IEA); GO_0009967 (EC: IPI, PMID: 11238452); GO_0016192 (EC: ISS); GO_0019894 (EC: IPI, PMID: 11238452); GO_0019901 (EC: IPI, PMID: 11238452); GO_0031434 (EC: IEA); GO_0031435 (EC: IEA); GO_0031966 (EC: IEA); GO_0042802 (EC: IEA); GO_0043066 (EC: IEA); GO_0043508 (EC: IEA); GO_0044294 (EC: IEA); GO_0044295 (EC: IEA); GO_0044297 (EC: IEA); GO_0044302 (EC: IEA); GO_0045202 (EC: IEA); GO_0046328 (EC: ISS); GO_0046329 (EC: IEA); GO_0048471 (EC: IEA); GO_2001243 (EC: IEA)
has PubMed association: PMID: 8619474; 9110174; 9235893; 9442013; 9733513; 9933567; 10490659; 10574993; 10629060; 10700186; 10748095; 10827173; 11147798; 11238452; 11517249; 11585908; 11700324; 11724784; 11726277; 11790792; 11907332; 11912189; 12024021; 12064607; 12194869; 12477932; 12508107; 12524447; 12563035; 12665528; 12740599; 12756254; 12783873; 12893827; 12917434; 12937412; 14507925; 15138488; 15868948; 15894166; 15911620; 15998799; 16169070; 16273093; 16301330; 16456539; 16533805; 16840345; 17200414; 17709393; 18055217; 18286207; 18480379; 19491104; 19616077; 20173330; 20205790; 21237154; 23172226; 23360921; 23770673; 24144296
description: mitogen-activated protein kinase 8 interacting protein 1
database cross reference: Ensembl:ENSG00000121653
database cross reference: HGNC:6882
database cross reference: HPRD:05223
database cross reference: MIM:604641
database cross reference: Vega:OTTHUMG00000134324

ADAMTS4
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ADAMTS-2
alternative term: ADAMTS-4
alternative term: ADMP-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ADAMTS4
full name from nomenclature authority: ADAM metallopeptidase with thrombospondin type 1 motif, 4
NCBI GeneID: 9507
NCBI LocusTag: UNQ769/PRO1563
gene map location: 1q21-q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001501 (EC: TAS, PMID: 10356395); GO_0002020 (EC: IPI, PMID: 14744861); GO_0004222 (EC: IEA); GO_0005515 (EC: IPI, PMID: 18718938); GO_0005576 (EC: TAS); GO_0005578 (EC: IEA); GO_0005615 (EC: IDA, PMID: 14744861); GO_0006508 (EC: TAS, PMID: 10751421); GO_0008233 (EC: TAS, PMID: 10751421); GO_0008237 (EC: TAS, PMID: 10356395); GO_0008270 (EC: IEA); GO_0022617 (EC: TAS); GO_0030198 (EC: TAS)
has PubMed association: PMID: 9734811; 10094461; 10356395; 10438522; 10464288; 10751421; 10801887; 10827174; 10986281; 11167130; 11254106; 11278559; 11796708; 11801682; 11831030; 11854269; 11956193; 12202483; 12477932; 12646579; 12975309; 14561220; 14662755; 14701864; 14715656; 14744861; 15161923; 15489334; 16003758; 16099106; 16188468; 16344560; 16677612; 16710414; 16723216; 16741450; 16771712; 17009305; 17095512; 17208315; 17265492; 17295438; 17311924; 17430884; 17470431; 17606262; 17978660; 18039650; 18042673; 18050214; 18156631; 18221525; 18387286; 18660489; 18671934; 18718938; 18941754; 19054571; 19322201; 19342688; 19643179; 19944557; 20625753; 20664926; 20857147; 21139048; 21334453; 21345877; 21664283; 21946608; 21988832; 22065068; 22324945; 22562232; 22670872; 22735305; 23082219; 23137648; 23295731; 23319426; 23438438; 23897278; 24051360
description: ADAM metallopeptidase with thrombospondin type 1 motif, 4
database cross reference: HGNC:220
database cross reference: HPRD:04853
database cross reference: MIM:603876

GDF15
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GDF-15
alternative term: MIC-1
alternative term: MIC1
alternative term: NAG-1
alternative term: PDF
alternative term: PLAB
alternative term: PTGFB
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GDF15
full name from nomenclature authority: growth differentiation factor 15
NCBI GeneID: 9518
gene map location: 19p13.11
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005125 (EC: IEA); GO_0005576 (EC: TAS, PMID: 9326641); GO_0005615 (EC: IEA); GO_0007165 (EC: TAS, PMID: 9326641); GO_0007179 (EC: TAS, PMID: 9348093); GO_0007267 (EC: TAS, PMID: 9326641); GO_0008083 (EC: IEA)
has PubMed association: PMID: 8125298; 9326641; 9348093; 9375789; 9426002; 9593718; 10524241; 10777512; 10811612; 11102463; 11134143; 11141057; 11259636; 11278594; 11445565; 11895857; 11994274; 12011055; 12082608; 12090982; 12139236; 12477932; 12514175; 12624183; 12855642; 12894347; 12900512; 12941831; 14575402; 14662774; 14726168; 15073115; 15316060; 15342369; 15670751; 15677629; 15757899; 15900300; 16154591; 16286461; 16388506; 16397141; 16484622; 16699947; 16741990; 16775185; 17050687; 17192395; 17328047; 17548705; 17637746; 17721544; 17908975; 17909264; 17982462; 18029348; 18264720; 18359786; 18398830; 18550273; 18624398; 18657084; 18676680; 18754039; 18801729; 18824595; 19047680; 19060904; 19074584; 19100681; 19125423; 19133249; 19152406; 19168526; 19170196; 19302795; 19341722; 19357976; 19375854; 19401523; 19470878; 19505289; 19505919; 19515791; 19521960; 19625176; 19692168; 19695766; 19913121; 19946339; 20024638; 20031597; 20067113; 20104227; 20130018; 20160200; 20167682; 20193126; 20215826; 20237496; 20357380; 20385121; 20431030; 20534737; 20576287; 20628086; 20800603; 20854422; 20855664; 20860541; 20884666; 20937742; 20966402; 20975101; 21097678; 21245963; 21312063; 21336029; 21437897; 21475976; 21487066; 21503121; 21504622; 21535154; 21548946; 21586550; 21616994; 21645023; 21773947; 21803025; 21809352; 21865063; 21881845; 21906983; 22023041; 22064648; 22144502; 22160844; 22180562; 22231869; 22301101; 22341306; 22365732; 22384099; 22484283; 22505696; 22511768; 22723347; 22815297; 22872134; 22975449; 23071585; 23146921; 23154866; 23262134; 23328263; 23335088; 23468844; 23503457; 23799024; 23836903; 23850849; 23996089; 24136234; 24345755
description: growth differentiation factor 15
database cross reference: Ensembl:ENSG00000130513
database cross reference: HGNC:30142
database cross reference: HPRD:05608
database cross reference: MIM:605312
database cross reference: Vega:OTTHUMG00000183360

BAG2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BAG-2
alternative term: dJ417I1.2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BAG2
full name from nomenclature authority: BCL2-associated athanogene 2
NCBI GeneID: 9532
NCBI LocusTag: RP3-496N17.2
gene map location: 6p12.1-p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 18457437); GO_0006457 (EC: TAS, PMID: 9873016); GO_0019538 (EC: IDA, PMID: 9873015); GO_0051087 (EC: IEA)
has PubMed association: PMID: 9873015; 9873016; 11076863; 11230166; 11256614; 12477932; 14574404; 14702039; 15271996; 15489334; 15489336; 16159877; 16169850; 16196087; 16207813; 16344560; 16381901; 17110338; 17203973; 17353931; 17569659; 18457437; 19156129; 19738201; 19875381; 20020773; 20547759; 21081666; 21139048; 21145461; 21906983; 21963094; 21987572; 22365833; 22451720; 22505724; 22863883; 22912744; 23000965; 23275444; 23349634; 23383273; 23398456; 23402259; 23438482; 23455922; 23667531; 23752268; 23824909; 23956138; 24244333; 24255178; 24318877; 24383081
description: BCL2-associated athanogene 2
database cross reference: HGNC:938
database cross reference: HPRD:04859
database cross reference: MIM:603882

VPS26A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HB58
alternative term: Hbeta58
alternative term: PEP8A
alternative term: VPS26
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: VPS26A
full name from nomenclature authority: vacuolar protein sorting 26 homolog A (S. pombe)
NCBI GeneID: 9559
gene map location: 10q21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 11102511); GO_0005768 (EC: IDA); GO_0005829 (EC: IDA, PMID: 11102511); GO_0005829 (EC: TAS); GO_0008565 (EC: NAS, PMID: 11102511); GO_0010008 (EC: IEA); GO_0031982 (EC: IDA); GO_0042147 (EC: NAS, PMID: 11102511); GO_0043231 (EC: IDA)
has PubMed association: PMID: 1638986; 9653160; 11042152; 11102511; 11598206; 12477932; 14702039; 15164054; 15247922; 15282546; 15489334; 16190980; 16196087; 16315276; 16407403; 16732284; 16784798; 17101778; 18781797; 19322201; 19531583; 19738201; 20619655; 20682791; 21139048; 21874001; 21875946; 21890473; 21906983; 21920005; 21963094; 22053931; 22284051; 22354992; 22610502; 22863883; 22939629; 23000965; 23452853; 23455922; 23903356
description: vacuolar protein sorting 26 homolog A (S. pombe)
database cross reference: Ensembl:ENSG00000122958
database cross reference: HGNC:12711
database cross reference: HPRD:08385
database cross reference: MIM:605506
database cross reference: Vega:OTTHUMG00000018376

NCOR1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: N-CoR
alternative term: N-CoR1
alternative term: TRAC1
alternative term: hN-CoR
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NCOR1
full name from nomenclature authority: nuclear receptor corepressor 1
NCBI GeneID: 9611
gene map location: 17p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000118 (EC: IDA, Qualifier: colocalizes_with, PMID: 18326024); GO_0000122 (EC: IMP, PMID: 12628926); GO_0000122 (EC: TAS); GO_0000790 (EC: IDA, PMID: 17505061); GO_0001102 (EC: IPI, PMID: 19955185); GO_0002361 (EC: IEA); GO_0003682 (EC: IEA); GO_0003700 (EC: IEA); GO_0003714 (EC: IDA, PMID: 18052923); GO_0003714 (EC: IMP, PMID: 12628926); GO_0005515 (EC: IPI, PMID: 10049357); GO_0005634 (EC: IC, PMID: 18052923); GO_0005634 (EC: IDA, PMID: 10049357); GO_0005654 (EC: TAS); GO_0005667 (EC: IEA); GO_0005737 (EC: IEA); GO_0005876 (EC: IDA, PMID: 18326024); GO_0006351 (EC: TAS); GO_0006366 (EC: TAS, PMID: 7566114); GO_0006367 (EC: TAS); GO_0007179 (EC: TAS); GO_0007219 (EC: TAS); GO_0010467 (EC: TAS); GO_0014067 (EC: IEA); GO_0016568 (EC: IEA); GO_0016580 (EC: IDA, Qualifier: colocalizes_with, PMID: 11486045); GO_0017053 (EC: IDA, PMID: 11804585); GO_0021794 (EC: IEA); GO_0031065 (EC: IEA); GO_0032922 (EC: IEA); GO_0035033 (EC: IEA); GO_0035257 (EC: IPI, PMID: 9328355); GO_0040014 (EC: IEA); GO_0042632 (EC: IEA); GO_0042826 (EC: IPI, PMID: 11804585); GO_0043565 (EC: IEA); GO_0044212 (EC: ISS); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0046329 (EC: IDA, PMID: 11931768); GO_0046965 (EC: IEA); GO_0046966 (EC: IEA); GO_0051225 (EC: IMP, PMID: 18326024); GO_0060318 (EC: IEA); GO_0072362 (EC: IMP, PMID: 19955185); GO_0072368 (EC: IMP, PMID: 19955185); GO_2000191 (EC: IC, PMID: 19955185)
has PubMed association: PMID: 7566114; 8948627; 9111334; 9121466; 9328355; 9405624; 9482666; 9486655; 9531570; 9611234; 9694793; 9702189; 9724795; 9751061; 9804773; 9819405; 9849963; 9878542; 10049357; 10077563; 10336495; 10406466; 10441075; 10441327; 10444336; 10470851; 10573424; 10640275; 10675041; 10734313; 10809664; 10860984; 10877839; 10882117; 10898795; 10940306; 10944117; 11001911; 11013263; 11113190; 11124027; 11331609; 11430826; 11439334; 11441023; 11463857; 11466315; 11486045; 11509652; 11533236; 11748154; 11804585; 11865059; 11867749; 11877444; 11889044; 11903058; 11931768; 11971970; 11997503; 12007404; 12011091; 12077342; 12089344; 12089345; 12145334; 12149646; 12150997; 12410313; 12460926; 12466959; 12477932; 12569182; 12590135; 12628926; 12634383; 12648520; 12663743; 12738788; 12764135; 12799135; 12840002; 12861000; 12890497; 12897056; 12904255; 14525983; 14527417; 14593076; 14667819; 14701861; 14702098; 14722073; 14761981; 14985122; 14985366; 15001550; 15016838; 15109542; 15116119; 15131262; 15175761; 15231748; 15256534; 15302935; 15333839; 15336696; 15377655; 15454082; 15531890; 15536134; 15561719; 15572376; 15598662; 15601853; 15604093; 15681609; 15695367; 15729358; 15761026; 15788656; 15802375; 15829968; 15832170; 15870285; 15878880; 15934135; 16024608; 16024779; 16030140; 16033423; 16121196; 16127449; 16141343; 16147992; 16195251; 16216492; 16227606; 16252006; 16373395; 16421255; 16464943; 16469706; 16712523; 16713569; 16730330; 16849648; 16914745; 16917504; 16964243; 17018285; 17073437; 17079677; 17081983; 17182846; 17210713; 17242407; 17255935; 17373667; 17400812; 17416745; 17440114; 17468099; 17468742; 17505061; 17519354; 17572682; 17620012; 17630505; 17768398; 18052923; 18202150; 18206970; 18292238; 18326024; 18362166; 18586123; 18632669; 18637017; 18660489; 18669643; 18829436; 18832723; 18852122; 18978041; 19011633; 19032343; 19048289; 19064572; 19098224; 19126649; 19147702; 19183483; 19211732; 19244234; 19414341; 19471022; 19608741; 19781322; 19913121; 19955185; 20…
description: nuclear receptor corepressor 1
database cross reference: Ensembl:ENSG00000141027
database cross reference: HGNC:7672
database cross reference: HPRD:02911
database cross reference: MIM:600849
database cross reference: Vega:OTTHUMG00000059309

NCOR2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CTG26
alternative term: N-CoR2
alternative term: SMAP270
alternative term: SMRT
alternative term: SMRTE
alternative term: SMRTE-tau
alternative term: TNRC14
alternative term: TRAC
alternative term: TRAC-1
alternative term: TRAC1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NCOR2
full name from nomenclature authority: nuclear receptor corepressor 2
NCBI GeneID: 9612
gene map location: 12q24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IDA, PMID: 10097068); GO_0000122 (EC: IMP, PMID: 12628926); GO_0000122 (EC: TAS); GO_0003677 (EC: IEA); GO_0003682 (EC: IEA); GO_0003714 (EC: IDA, PMID: 18052923); GO_0003714 (EC: IMP, PMID: 12628926); GO_0005112 (EC: IPI, PMID: 10713164); GO_0005515 (EC: IPI, PMID: 10395741); GO_0005634 (EC: IC, PMID: 18052923); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0006351 (EC: TAS); GO_0006367 (EC: TAS); GO_0007179 (EC: TAS); GO_0007219 (EC: TAS); GO_0010467 (EC: TAS); GO_0016363 (EC: IDA); GO_0016604 (EC: IDA, PMID: 16030140); GO_0017053 (EC: IDA, PMID: 11804585); GO_0042826 (EC: IPI, PMID: 11804585); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0047485 (EC: IPI, PMID: 16893456); GO_0072365 (EC: IMP, PMID: 19955185)
has PubMed association: PMID: 7566114; 7566127; 8813722; 8889548; 9171229; 9225980; 9256429; 9267036; 9380707; 9405624; 9415406; 9486654; 9702189; 9751500; 9765306; 9819405; 9878542; 10049357; 10077563; 10082574; 10097068; 10395741; 10406466; 10611298; 10640275; 10640276; 10644367; 10713164; 10757795; 10777532; 10809664; 10860984; 10869435; 10898795; 10944117; 11013263; 11113190; 11134019; 11158331; 11259580; 11331609; 11404076; 11430826; 11435691; 11466315; 11509652; 11509665; 11518802; 11559707; 11585900; 11726519; 11739383; 11804585; 11845213; 11865059; 11867749; 11923464; 11929748; 11929749; 11931768; 11959865; 11972046; 11997503; 12007404; 12011091; 12072427; 12107410; 12139968; 12205093; 12242670; 12388540; 12441355; 12460926; 12477932; 12502735; 12554770; 12589049; 12628926; 12665583; 12738788; 12771131; 12840002; 12904255; 12970571; 14527417; 14593076; 14690607; 14715875; 14982881; 14985122; 15016838; 15016912; 15062576; 15146197; 15175761; 15231748; 15300237; 15302935; 15319284; 15454082; 15494311; 15531890; 15536134; 15604093; 15632172; 15635693; 15681609; 15713534; 15729358; 15802375; 15832170; 15837933; 15843525; 15870285; 15878880; 16002533; 16024608; 16030140; 16033423; 16042694; 16121196; 16129689; 16144941; 16147992; 16219912; 16373395; 16382138; 16453284; 16480812; 16481466; 16613989; 16712523; 16893456; 16924111; 16956611; 17000644; 17043677; 17073437; 17081983; 17126328; 17242407; 17347654; 17356171; 17383980; 17475621; 17560331; 17902051; 17991421; 18029348; 18052923; 18187620; 18212045; 18347093; 18362166; 18487509; 18546531; 18632669; 18660489; 18838553; 18852122; 18950845; 19098224; 19144721; 19183483; 19211732; 19223455; 19244234; 19417136; 19432593; 19471022; 19596686; 19617623; 19730683; 19734545; 19851296; 19904269; 19934400; 19955185; 20003447; 20195357; 20198315; 20364085; 20392877; 20555024; 20812024; 20935208; 20965228; 21081666; 21083371; 21088000; 21131350; 21139048; 21143702; 21240272; 21258344; 21282530; 21518914; 21532573; 21624135; 21693764; 22185585; 2…
description: nuclear receptor corepressor 2
database cross reference: Ensembl:ENSG00000196498
database cross reference: HGNC:7673
database cross reference: HPRD:02910
database cross reference: MIM:600848
database cross reference: Vega:OTTHUMG00000150455

ATG13
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: KIAA0652
alternative term: PARATARG8
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ATG13
full name from nomenclature authority: autophagy related 13
NCBI GeneID: 9776
gene map location: 11p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000045 (EC: IMP, PMID: 19211835); GO_0000407 (EC: ISS); GO_0005515 (EC: IPI, PMID: 19211835); GO_0005829 (EC: IEA); GO_0019901 (EC: IPI, PMID: 18936157); GO_0070969 (EC: IPI, PMID: 19211835)
has PubMed association: PMID: 8125298; 8619474; 9110174; 9734811; 12107413; 12477932; 14702039; 15489334; 16196087; 16344560; 17204848; 17207965; 18936157; 19211835; 19225151; 19258318; 19287211; 19597335; 19690328; 20562859; 20694011; 21460630; 21475306; 21832049; 21900206; 21976705; 23043107; 23524951; 24100292
description: autophagy related 13
database cross reference: Ensembl:ENSG00000175224
database cross reference: HGNC:29091
database cross reference: HPRD:13809
database cross reference: MIM:615088
database cross reference: Vega:OTTHUMG00000166538

NUPL1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PRO2463
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NUPL1
full name from nomenclature authority: nucleoporin like 1
NCBI GeneID: 9818
NCBI LocusTag: RP11-206I15.1
gene map location: 13q12.13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 13
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000278 (EC: TAS); GO_0005487 (EC: IEA); GO_0005515 (EC: IPI, PMID: 17500595); GO_0005635 (EC: TAS); GO_0005643 (EC: IEA); GO_0005975 (EC: TAS); GO_0007077 (EC: TAS); GO_0008645 (EC: TAS); GO_0010827 (EC: TAS); GO_0015031 (EC: IEA); GO_0015758 (EC: TAS); GO_0016032 (EC: TAS); GO_0019221 (EC: TAS); GO_0031965 (EC: IEA); GO_0044281 (EC: TAS); GO_0051028 (EC: IEA); GO_0055085 (EC: TAS)
has PubMed association: PMID: 7531196; 8889548; 9455477; 10601273; 11266456; 12228227; 12477932; 14702039; 15342556; 15489334; 17500595; 20936779; 21139048; 21890473; 21900206; 21906983; 22505724; 22939629; 23000965; 23275563; 23383273
description: nucleoporin like 1
database cross reference: Ensembl:ENSG00000139496
database cross reference: HGNC:20261
database cross reference: HPRD:06355
database cross reference: MIM:607615
database cross reference: Vega:OTTHUMG00000016608

RB1CC1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ATG17
alternative term: CC1
alternative term: FIP200
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: RB1CC1
full name from nomenclature authority: RB1-inducible coiled-coil 1
NCBI GeneID: 9821
gene map location: 8q11
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000045 (EC: IEA); GO_0001889 (EC: IEA); GO_0001934 (EC: IEA); GO_0005515 (EC: IPI, PMID: 19211835); GO_0005737 (EC: IDA); GO_0005829 (EC: IEA); GO_0006351 (EC: IEA); GO_0006355 (EC: IEA); GO_0007049 (EC: IEA); GO_0007254 (EC: IEA); GO_0007507 (EC: IEA); GO_0010506 (EC: ISS); GO_0019901 (EC: IEA); GO_0031965 (EC: IDA); GO_0034045 (EC: ISS); GO_0043066 (EC: IEA); GO_0045793 (EC: IEA); GO_0070969 (EC: IPI, PMID: 19211835); GO_2001237 (EC: IEA)
has PubMed association: PMID: 7724523; 9039502; 10769033; 11850849; 12068296; 12095676; 12163359; 12221124; 12477932; 14533007; 15375585; 15489334; 15968549; 16043512; 16061648; 16344560; 16865226; 17015619; 17081983; 17353931; 17706618; 17707572; 17986458; 18036779; 18285457; 18443221; 18676680; 18976975; 19170196; 19211835; 19225151; 19258318; 19437535; 19625176; 19690328; 19692168; 19888451; 20301425; 20453000; 20562859; 20614030; 21139048; 21203526; 21602932; 21637919; 21717524; 21775823; 21795712; 21822266; 21903422; 21988832; 22049074; 22396748; 22751121; 23043107; 23262492; 23289756; 23602568; 23885119; 24100292; 24250222
description: RB1-inducible coiled-coil 1
database cross reference: Ensembl:ENSG00000023287
database cross reference: HGNC:15574
database cross reference: HPRD:06019
database cross reference: MIM:606837
database cross reference: Vega:OTTHUMG00000164268

GAB2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GAB2
full name from nomenclature authority: GRB2-associated binding protein 2
NCBI GeneID: 9846
gene map location: 11q14.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005068 (EC: IDA, PMID: 19172738); GO_0005070 (EC: RCA, PMID: 19641626); GO_0005515 (EC: IPI, PMID: 15170389); GO_0005547 (EC: ISS); GO_0005737 (EC: IDA, PMID: 19172738); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 19172738); GO_0007169 (EC: IDA, PMID: 19172738); GO_0008284 (EC: IDA, PMID: 19172738); GO_0009967 (EC: RCA, PMID: 19641626); GO_0030316 (EC: IMP, PMID: 15750601); GO_0038095 (EC: TAS); GO_0043306 (EC: ISS); GO_0043325 (EC: ISS); GO_0045087 (EC: TAS); GO_0048015 (EC: ISS)
has PubMed association: PMID: 9628581; 10068651; 10391903; 10455108; 10704825; 10752981; 10871282; 10913131; 11287610; 11334882; 11402314; 11466412; 11572860; 11701952; 11782427; 11812650; 11830491; 11882361; 11895767; 11971018; 11997510; 12008033; 12135708; 12140767; 12176364; 12477932; 12522270; 12819203; 14530346; 14687710; 14982882; 15010462; 15143164; 15170389; 15356145; 15574337; 15750601; 15952937; 16135792; 16219545; 16253990; 16344560; 16368877; 16369543; 16736498; 17553421; 17998934; 18235045; 18272374; 18314909; 18644434; 18697750; 18853460; 18854865; 19118819; 19172738; 19204163; 19233262; 19262956; 19276544; 19342374; 19380743; 19509136; 19523899; 19608861; 19641626; 19838208; 19881546; 19909739; 19913121; 19924507; 20087860; 20188796; 20237496; 20413850; 20534741; 20574532; 20628086; 20634593; 20697350; 20888920; 20936779; 21102462; 21108942; 21118992; 21285854; 21552417; 21653832; 21706016; 21996746; 22851227; 22856364; 22859374; 22883624; 22926523; 23401857; 23525328; 23724096; 24161894; 24385586
description: GRB2-associated binding protein 2

GFPT2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GFAT2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GFPT2
full name from nomenclature authority: glutamine-fructose-6-phosphate transaminase 2
NCBI GeneID: 9945
gene map location: 5q34-q35
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004360 (EC: IEA); GO_0005829 (EC: TAS); GO_0006002 (EC: TAS, PMID: 10198162); GO_0006048 (EC: IEA); GO_0006048 (EC: TAS); GO_0006112 (EC: TAS, PMID: 10198162); GO_0006488 (EC: TAS); GO_0006541 (EC: IEA); GO_0016051 (EC: IEA); GO_0018279 (EC: TAS); GO_0030246 (EC: IEA); GO_0043687 (EC: TAS); GO_0044267 (EC: TAS)
has PubMed association: PMID: 10198162; 12477932; 14702039; 14764791; 15489334; 17081983; 17542649; 17574229; 20353610; 20881960; 21044950; 21145461; 21897333; 21906983; 22505724; 23314748
description: glutamine-fructose-6-phosphate transaminase 2
database cross reference: Ensembl:ENSG00000131459
database cross reference: HGNC:4242
database cross reference: HPRD:04842
database cross reference: MIM:603865
database cross reference: Vega:OTTHUMG00000163442

MED12
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ARC240
alternative term: CAGH45
alternative term: FGS1
alternative term: HOPA
alternative term: MED12S
alternative term: OHDOX
alternative term: OKS
alternative term: OPA1
alternative term: TNRC11
alternative term: TRAP230
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MED12
full name from nomenclature authority: mediator complex subunit 12
NCBI GeneID: 9968
gene map location: Xq13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000980 (EC: IEA); GO_0001104 (EC: IDA, PMID: 10198638); GO_0001190 (EC: IEA); GO_0001843 (EC: IEA); GO_0003682 (EC: IEA); GO_0003712 (EC: IDA, PMID: 12218053); GO_0003713 (EC: IDA, PMID: 12037571); GO_0004872 (EC: IDA, PMID: 12218053); GO_0005515 (EC: IPI); GO_0005634 (EC: IDA, PMID: 10235267); GO_0005654 (EC: TAS); GO_0006367 (EC: IDA, PMID: 12218053); GO_0006367 (EC: TAS); GO_0007507 (EC: IEA); GO_0008013 (EC: IEA); GO_0008022 (EC: IPI, PMID: 17000779); GO_0010467 (EC: TAS); GO_0014003 (EC: IEA); GO_0014044 (EC: IEA); GO_0016592 (EC: IDA, PMID: 10198638); GO_0019827 (EC: IEA); GO_0019904 (EC: IPI, PMID: 11984006); GO_0030178 (EC: IMP, PMID: 17000779); GO_0030374 (EC: NAS, PMID: 10235266); GO_0030518 (EC: IDA, PMID: 11867769); GO_0030521 (EC: IDA, PMID: 12218053); GO_0042809 (EC: NAS, PMID: 10235266); GO_0045893 (EC: IDA, PMID: 10198638); GO_0045944 (EC: IDA, PMID: 12037571); GO_0046966 (EC: IDA, PMID: 10198638); GO_0060070 (EC: IEA); GO_0060071 (EC: IEA); GO_0090245 (EC: IEA)
has PubMed association: PMID: 8710870; 8724849; 8781769; 8889548; 9225980; 9375929; 9702738; 10198638; 10235266; 10235267; 10480376; 10882111; 11424983; 11524702; 11834832; 11840515; 11867769; 11984006; 12037571; 12136106; 12216017; 12218053; 12477932; 12584197; 12612078; 12627458; 12660246; 12777533; 12860370; 14636573; 14638676; 14657022; 15108174; 15175163; 15717329; 15989967; 16109376; 16344560; 16538184; 16565090; 16799563; 17000779; 17081983; 17088561; 17110338; 17299734; 17334363; 17369503; 17716226; 17967894; 18029348; 18418385; 18691967; 18973276; 19036726; 19047373; 19240132; 19596686; 20098423; 20133760; 20301719; 20507344; 20508642; 20720539; 21139048; 21293490; 21729782; 21868628; 21890473; 21963094; 21987572; 22182697; 22223266; 22428002; 22505724; 22532225; 22586326; 22768200; 22939629; 23091001; 23132392; 23178117; 23222489; 23225304; 23275444; 23322298; 23347103; 23395478; 23517922; 23563140; 23602568; 23635816; 23661306; 23913526; 24163370; 24196187; 24457600
description: mediator complex subunit 12
database cross reference: Ensembl:ENSG00000184634
database cross reference: HGNC:11957
database cross reference: HPRD:02176
database cross reference: MIM:300188
database cross reference: Vega:OTTHUMG00000021788

SRA1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SRA
alternative term: SRAP
alternative term: STRAA1
alternative term: pp7684
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SRA1
full name from nomenclature authority: steroid receptor RNA activator 1
NCBI GeneID: 10011
NCBI LocusTag: PP7684
gene map location: 5q31.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003677 (EC: IEA); GO_0003713 (EC: IDA, PMID: 10199399); GO_0005515 (EC: IPI, PMID: 16595694); GO_0005634 (EC: IDA); GO_0005667 (EC: IEA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005886 (EC: IDA); GO_0006351 (EC: IEA); GO_0006915 (EC: IEA); GO_0008283 (EC: IDA, PMID: 14517287); GO_0010861 (EC: IEA); GO_0015630 (EC: IDA); GO_0030154 (EC: IDA, PMID: 14517287); GO_0030374 (EC: IBA); GO_0030529 (EC: IPI, PMID: 10199399); GO_0031252 (EC: IEA); GO_0042981 (EC: IDA, PMID: 14517287); GO_0045171 (EC: IDA); GO_0045944 (EC: IEA); GO_2000273 (EC: IBA)
has PubMed association: PMID: 10199399; 10485452; 11103781; 11250900; 11331609; 11438648; 11818499; 12118039; 12163482; 12444263; 12477932; 12565891; 12909012; 12943696; 14517287; 14702039; 14715875; 15147866; 15180993; 15327771; 15351741; 15489334; 15498874; 15607539; 16152589; 16169070; 16344560; 16540468; 16595694; 16607388; 16773180; 16848684; 17702747; 18676680; 18827892; 18950845; 19064572; 19064678; 19188450; 19483093; 19625176; 19692168; 19740422; 20079837; 20153324; 20219889; 20398657; 20677014; 20855289; 20966046; 21771633; 21790861; 21807064; 21906983; 22362738; 22939629; 22998747; 23907597
description: steroid receptor RNA activator 1
database cross reference: Ensembl:ENSG00000213523
database cross reference: HGNC:11281
database cross reference: HPRD:18716
database cross reference: MIM:603819
database cross reference: Vega:OTTHUMG00000163569

NR1H3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LXR-a
alternative term: LXRA
alternative term: RLD-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NR1H3
full name from nomenclature authority: nuclear receptor subfamily 1, group H, member 3
NCBI GeneID: 10062
gene map location: 11p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: ISS); GO_0000790 (EC: IDA, PMID: 18511497); GO_0003677 (EC: TAS, PMID: 7744246); GO_0003707 (EC: IEA); GO_0003713 (EC: TAS, PMID: 7744246); GO_0004879 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12040021); GO_0005634 (EC: TAS, PMID: 7744246); GO_0005654 (EC: TAS); GO_0006367 (EC: TAS); GO_0008270 (EC: IEA); GO_0010467 (EC: TAS); GO_0010745 (EC: IC, PMID: 17693624); GO_0010867 (EC: IMP, PMID: 17693624); GO_0010870 (EC: IDA, PMID: 18511497); GO_0010875 (EC: IDA, PMID: 16141411); GO_0010875 (EC: IMP, PMID: 17186944); GO_0010887 (EC: IMP, PMID: 17693624); GO_0015485 (EC: TAS, PMID: 11090131); GO_0032270 (EC: IMP, PMID: 17186944); GO_0032369 (EC: IMP, PMID: 17693624); GO_0032376 (EC: IDA, PMID: 16141411); GO_0032570 (EC: IDA, PMID: 16141411); GO_0032810 (EC: IDA, PMID: 19628791); GO_0034145 (EC: IDA, PMID: 18511497); GO_0042632 (EC: ISS); GO_0042752 (EC: TAS, PMID: 18511497); GO_0043031 (EC: ISS); GO_0043277 (EC: IMP, PMID: 19628791); GO_0043565 (EC: IEA); GO_0044212 (EC: IDA, PMID: 19229075); GO_0044212 (EC: IDA, Qualifier: contributes_to, PMID: 18511497); GO_0044255 (EC: IEA); GO_0045723 (EC: IMP, PMID: 17186944); GO_0045861 (EC: IEA); GO_0045893 (EC: IMP, PMID: 19628791); GO_0045944 (EC: IDA, PMID: 16141411); GO_0045944 (EC: IMP, PMID: 17186944); GO_0048550 (EC: IMP, PMID: 17693624); GO_0050728 (EC: ISS); GO_0051006 (EC: IMP, PMID: 17186944); GO_0055088 (EC: ISS); GO_0055092 (EC: ISS); GO_0060336 (EC: NAS); GO_0070328 (EC: ISS); GO_0071222 (EC: IDA, PMID: 18511497); GO_0090188 (EC: ISS); GO_0090341 (EC: ISS); GO_2000188 (EC: ISS); GO_2000189 (EC: IDA, PMID: 18511497)
has PubMed association: PMID: 7744246; 8510758; 8621574; 9013544; 9231657; 9630215; 10022764; 11035776; 11090131; 11135616; 11149950; 11875109; 12032151; 12040021; 12054659; 12117567; 12161442; 12198243; 12470296; 12477932; 12663743; 12724417; 12932788; 12957674; 14699103; 14702039; 15319359; 15342556; 15353176; 15489334; 15489335; 15539633; 15548517; 15604093; 15615782; 15625283; 16054077; 16106051; 16141411; 16143103; 16170053; 16249184; 16341674; 16344560; 16354658; 16482468; 16567856; 16758300; 16904112; 16920108; 16941683; 16956579; 16973760; 17108812; 17110595; 17135302; 17186944; 17217555; 17218271; 17255360; 17272748; 17296605; 17391100; 17396233; 17405904; 17416342; 17452725; 17628006; 17644777; 17693624; 17724434; 17766241; 17845217; 17936707; 17960176; 18007013; 18024509; 18096827; 18182682; 18209740; 18250151; 18276933; 18327405; 18372238; 18511497; 18562803; 18636124; 18660489; 18669643; 18789440; 18854425; 19060910; 19105208; 19119143; 19164445; 19201410; 19211025; 19229075; 19261092; 19292929; 19360318; 19366697; 19380774; 19426978; 19436111; 19481530; 19628791; 19645823; 19697157; 19796621; 19798078; 19837721; 19913121; 19933273; 20005944; 20037595; 20057170; 20080977; 20118482; 20139031; 20190811; 20211142; 20219900; 20237496; 20364260; 20410489; 20494359; 20506155; 20628086; 20655109; 20686565; 20836841; 20837115; 20855565; 20868688; 20945144; 21042792; 21125317; 21136146; 21187453; 21245992; 21266776; 21310851; 21315073; 21316679; 21349840; 21350215; 21356276; 21440016; 21562465; 21625070; 21775116; 21832049; 21889884; 21903943; 21937108; 21951066; 21988832; 22027013; 22137263; 22257474; 22311022; 22367754; 22399489; 22399527; 22457708; 22503545; 22547570; 22569763; 22610535; 22623531; 22634718; 22641099; 22707265; 22723445; 22749359; 22766509; 22916038; 22939624; 22969086; 22984430; 22990668; 23018104; 23041609; 23099324; 23163651; 23185273; 23313547; 23393188; 23416078; 23451202; 23455924; 23496987; 23564066; 23680128; 23732298; 23733886; 23838803; 23867395; 24009820; …
description: nuclear receptor subfamily 1, group H, member 3
database cross reference: Ensembl:ENSG00000025434
database cross reference: HGNC:7966
database cross reference: HPRD:07211
database cross reference: MIM:602423
database cross reference: Vega:OTTHUMG00000150628

ARL4C
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ARL7
alternative term: LAK
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ARL4C
full name from nomenclature authority: ADP-ribosylation factor-like 4C
NCBI GeneID: 10123
gene map location: 2q37.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003924 (EC: TAS, PMID: 10462049); GO_0005515 (EC: IPI, PMID: 17398095); GO_0005525 (EC: IEA); GO_0005634 (EC: TAS, PMID: 10462049); GO_0005737 (EC: IDA); GO_0005886 (EC: IDA); GO_0006184 (EC: TAS, PMID: 10462049); GO_0007264 (EC: IEA); GO_0030175 (EC: IEA); GO_0032456 (EC: IDA, PMID: 19409876); GO_0043014 (EC: IDA, PMID: 19409876)
has PubMed association: PMID: 10462049; 12477932; 15147902; 15489334; 16713569; 17398095; 18029348; 19409876; 20686608; 21187453; 21832049; 21890473; 21906983; 21963094; 23000965
description: ADP-ribosylation factor-like 4C
database cross reference: Ensembl:ENSG00000188042
database cross reference: HGNC:698
database cross reference: HPRD:11988
database cross reference: MIM:604787
database cross reference: Vega:OTTHUMG00000133291

GDF11
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BMP-11
alternative term: BMP11
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GDF11
full name from nomenclature authority: growth differentiation factor 11
NCBI GeneID: 10220
gene map location: 12q13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001501 (EC: TAS, PMID: 10391213); GO_0001656 (EC: IEA); GO_0001657 (EC: IEA); GO_0005125 (EC: IEA); GO_0005575 (EC: ND); GO_0005615 (EC: IEA); GO_0007399 (EC: TAS, PMID: 10075854); GO_0007498 (EC: TAS, PMID: 10075854); GO_0008083 (EC: IEA); GO_0008285 (EC: IEA); GO_0021512 (EC: IEA); GO_0031016 (EC: IEA); GO_0040007 (EC: IEA); GO_0045596 (EC: IEA); GO_0048469 (EC: IEA); GO_0048593 (EC: IEA)
has PubMed association: PMID: 8889549; 10075854; 10391213; 10508689; 15988002; 16845371; 17912435; 17997109; 18519639; 18535106; 18596030; 19751112; 20734064
description: growth differentiation factor 11
database cross reference: Ensembl:ENSG00000135414
database cross reference: HGNC:4216
database cross reference: HPRD:04895
database cross reference: MIM:603936
database cross reference: Vega:OTTHUMG00000170188

STUB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CHIP
alternative term: HSPABP2
alternative term: NY-CO-7
alternative term: SDCCAG7
alternative term: UBOX1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: STUB1
full name from nomenclature authority: STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
NCBI GeneID: 10273
NCBI LocusTag: LA16c-313D11.6
gene map location: 16p13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000151 (EC: IDA, PMID: 16275660); GO_0000209 (EC: IDA, PMID: 15781469); GO_0000209 (EC: IMP, PMID: 19713937); GO_0004842 (EC: IDA, PMID: 15466472); GO_0004842 (EC: IMP, PMID: 19713937); GO_0004842 (EC: TAS, PMID: 16307917); GO_0005515 (EC: IPI, PMID: 11146632); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA); GO_0006281 (EC: IEA); GO_0006511 (EC: IMP, PMID: 19713937); GO_0006515 (EC: IDA, PMID: 16831871); GO_0007179 (EC: TAS); GO_0019899 (EC: IPI, PMID: 16280320); GO_0019900 (EC: IPI, PMID: 17512523); GO_0030512 (EC: TAS); GO_0030544 (EC: IDA, PMID: 10330192); GO_0030579 (EC: IDA, PMID: 15781469); GO_0030674 (EC: TAS, PMID: 16307917); GO_0030911 (EC: IDA, PMID: 11146632); GO_0031371 (EC: TAS, PMID: 16307917); GO_0031398 (EC: IDA, PMID: 11146632); GO_0031625 (EC: IEA); GO_0031943 (EC: IDA, PMID: 11146632); GO_0032436 (EC: IDA, PMID: 11146632); GO_0034450 (EC: ISS); GO_0042405 (EC: IDA, PMID: 16831871); GO_0042803 (EC: ISS); GO_0043161 (EC: IDA, PMID: 15781469); GO_0045111 (EC: IDA); GO_0046332 (EC: IDA, PMID: 15781469); GO_0051604 (EC: TAS, PMID: 16307917); GO_0051787 (EC: IDA, PMID: 16831871); GO_0051865 (EC: IDA, PMID: 16307917); GO_0051879 (EC: IDA, PMID: 11146632); GO_0070534 (EC: IDA, PMID: 16307917); GO_0071218 (EC: IDA, PMID: 16831871); GO_0090035 (EC: IDA, PMID: 16831871)
has PubMed association: PMID: 9610721; 10330192; 11146632; 11146634; 11157797; 11557750; 11676916; 11743028; 11805346; 12150907; 12200376; 12239347; 12477932; 12559985; 12574167; 12837759; 14532117; 14532270; 14612456; 14701756; 14962978; 15001357; 15046863; 15107424; 15189447; 15198682; 15215316; 15254225; 15302935; 15358145; 15447663; 15456869; 15466472; 15489334; 15525661; 15538384; 15611333; 15694383; 15708501; 15761032; 15761153; 15781469; 15911628; 15936278; 16037132; 16038411; 16111477; 16135753; 16169070; 16169850; 16207813; 16275660; 16280320; 16293251; 16307917; 16621797; 16682404; 16712791; 16714300; 16720573; 16725394; 16740632; 16809764; 16831871; 16895519; 16964243; 17081983; 17127076; 17157513; 17178836; 17209571; 17239458; 17304350; 17317785; 17324930; 17512523; 17545168; 17595347; 17666403; 17873020; 17875712; 17962192; 17963781; 18042044; 18094050; 18223694; 18292230; 18313385; 18388150; 18411298; 18436529; 18457437; 18485199; 18541707; 18655187; 18678647; 18718056; 18784277; 18818696; 18955503; 18988734; 19011619; 19056735; 19098309; 19103148; 19153604; 19165527; 19196961; 19198599; 19237536; 19240029; 19306926; 19362296; 19406989; 19465479; 19471022; 19478201; 19483080; 19524548; 19536328; 19648119; 19706771; 19713937; 19818709; 19875381; 19892702; 19913553; 19940151; 20029029; 20146531; 20151404; 20349136; 20413784; 20466727; 20588253; 20618441; 20661446; 20675402; 20677910; 20704274; 20724525; 20729196; 20811636; 20924358; 20943656; 20947504; 20947508; 20959453; 20974249; 20974815; 21044950; 21124777; 21139048; 21157430; 21209460; 21220432; 21268072; 21272160; 21293491; 21325980; 21358815; 21360678; 21454478; 21518764; 21549100; 21625540; 21652633; 21710689; 21767636; 21775628; 21793045; 21855799; 21860411; 21898230; 21911421; 21942715; 21988832; 21995445; 22038067; 22090276; 22101235; 22118674; 22128174; 22190034; 22190037; 22254155; 22271573; 22350907; 22350919; 22407479; 22427670; 22433856; 22492994; 22535373; 22543587; 22551455; 22670667; 22734001; 22824801; 22842…
description: STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
database cross reference: Ensembl:ENSG00000103266
database cross reference: HGNC:11427
database cross reference: HPRD:06232
database cross reference: MIM:607207
database cross reference: Vega:OTTHUMG00000121140

CCL26
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IMAC
alternative term: MIP-4a
alternative term: MIP-4alpha
alternative term: SCYA26
alternative term: TSC-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCL26
full name from nomenclature authority: chemokine (C-C motif) ligand 26
NCBI GeneID: 10344
NCBI LocusTag: UNQ216/PRO242
gene map location: 7q11.23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001938 (EC: IDA, PMID: 19525930); GO_0005615 (EC: IEA); GO_0006935 (EC: TAS, PMID: 10373330); GO_0006954 (EC: IEA); GO_0006955 (EC: IEA); GO_0007165 (EC: NAS, PMID: 10373330); GO_0007267 (EC: TAS, PMID: 10373330); GO_0008009 (EC: IEA); GO_0030335 (EC: IDA, PMID: 19525930); GO_0030838 (EC: IDA, PMID: 19525930); GO_0032855 (EC: IDA, PMID: 19525930); GO_0060326 (EC: TAS, PMID: 10373330)
has PubMed association: PMID: 9847074; 10373330; 10415065; 10488147; 11329013; 11425309; 11544308; 11748272; 12061839; 12192108; 12477932; 12689946; 12853948; 12975309; 15039444; 15207712; 15489334; 15521376; 15784470; 15863444; 16084752; 16264039; 16391516; 16453027; 16604488; 17073866; 17490641; 17541284; 17703412; 17900656; 18055844; 18712274; 18774776; 18844613; 19141347; 19141349; 19203252; 19258923; 19331716; 19379605; 19423540; 19525930; 19567623; 20056178; 20059579; 20143648; 20236835; 20406964; 20438785; 20503287; 20505746; 20974991; 21077277; 21266446; 21303604; 21325281; 21493274; 21832049; 21881593; 21985360; 22226123; 22580413; 22739041; 22846146; 22946025; 22948508; 22952702; 23185525; 23477905; 23532518; 23607908; 24323578; 24600981
description: chemokine (C-C motif) ligand 26
database cross reference: Ensembl:ENSG00000006606
database cross reference: HGNC:10625
database cross reference: HPRD:05262
database cross reference: MIM:604697
database cross reference: Vega:OTTHUMG00000130403

ABCA7
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ABCA-SSN
alternative term: ABCX
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ABCA7
full name from nomenclature authority: ATP-binding cassette, sub-family A (ABC1), member 7
NCBI GeneID: 10347
gene map location: 19p13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: IEA); GO_0005215 (EC: TAS, PMID: 10873640); GO_0005524 (EC: IEA); GO_0005548 (EC: IEA); GO_0005737 (EC: IDA); GO_0005794 (EC: IDA); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0006909 (EC: IEA); GO_0010008 (EC: IEA); GO_0016021 (EC: TAS, PMID: 10873640); GO_0016324 (EC: IEA); GO_0016887 (EC: IEA); GO_0033700 (EC: IEA); GO_0043190 (EC: TAS, PMID: 10873640); GO_0055085 (EC: TAS)
has PubMed association: PMID: 8889548; 10873640; 11054552; 11095984; 11355874; 11435699; 12111378; 12917409; 12925201; 14570867; 14592415; 14702039; 15203218; 15593299; 15930518; 16908670; 18029348; 18676680; 19170196; 19343046; 19625176; 19692168; 19721717; 19913121; 20628086; 20855565; 21173549; 21460840; 21460841; 21906983; 23324282; 23571587; 23669301; 24097981; 24141082
description: ATP-binding cassette, sub-family A (ABC1), member 7
database cross reference: Ensembl:ENSG00000064687
database cross reference: HGNC:37
database cross reference: HPRD:09255
database cross reference: MIM:605414
database cross reference: Vega:OTTHUMG00000167547

NOD1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CARD4
alternative term: CLR7.1
alternative term: NLRC1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NOD1
full name from nomenclature authority: nucleotide-binding oligomerization domain containing 1
NCBI GeneID: 10392
gene map location: 7p15-p14
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: TAS); GO_0002224 (EC: TAS); GO_0002606 (EC: ISS); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0005515 (EC: IPI, PMID: 15107016); GO_0005524 (EC: IEA); GO_0005737 (EC: IDA, PMID: 10329646); GO_0005737 (EC: TAS, PMID: 15967716); GO_0005829 (EC: TAS); GO_0006915 (EC: TAS, PMID: 10329646); GO_0006919 (EC: IDA, PMID: 10329646); GO_0006952 (EC: TAS, PMID: 15967716); GO_0006954 (EC: TAS, PMID: 15967716); GO_0007165 (EC: TAS, PMID: 15967716); GO_0007254 (EC: TAS); GO_0008656 (EC: TAS, PMID: 10329646); GO_0009595 (EC: TAS, PMID: 15967716); GO_0016045 (EC: IDA, PMID: 15653568); GO_0016323 (EC: IDA, PMID: 19043560); GO_0016324 (EC: IEA); GO_0032755 (EC: IEA); GO_0032760 (EC: IEA); GO_0034134 (EC: TAS); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035556 (EC: IDA, PMID: 15653568); GO_0035666 (EC: TAS); GO_0035872 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042228 (EC: IDA, PMID: 15653568); GO_0042742 (EC: IDA, PMID: 15653568); GO_0042802 (EC: IDA, PMID: 10329646); GO_0042802 (EC: IPI, PMID: 18186648); GO_0042803 (EC: IPI, PMID: 18186648); GO_0042834 (EC: TAS, PMID: 15967716); GO_0043123 (EC: IDA, PMID: 10329646); GO_0043280 (EC: IDA, PMID: 10329646); GO_0045087 (EC: TAS); GO_0046330 (EC: IEA); GO_0050700 (EC: IDA, PMID: 10329646); GO_0050830 (EC: IEA); GO_0051092 (EC: IDA, PMID: 17054981); GO_0051092 (EC: TAS); GO_0051259 (EC: TAS, PMID: 15967716); GO_0051403 (EC: TAS); GO_0070374 (EC: IEA); GO_0070423 (EC: TAS)
has PubMed association: PMID: 10224040; 10329646; 10880512; 11058605; 11113115; 12459189; 12477932; 12690205; 12761501; 12775719; 12791997; 12813035; 12853948; 12871942; 14702039; 14977954; 15107016; 15276183; 15489334; 15653568; 15657077; 15718249; 15790594; 15967716; 15990792; 16083881; 16115863; 16172124; 16260731; 16446438; 16464805; 16493424; 16517750; 16741608; 16893397; 16918516; 16935475; 17005562; 17012967; 17030188; 17054981; 17100974; 17156193; 17285593; 17309748; 17322292; 17337451; 17403538; 17420470; 17435760; 17452051; 17521327; 17595233; 17613538; 17620097; 17907287; 17964870; 17970764; 18186648; 18397186; 18426885; 18521924; 18536738; 18573991; 18574154; 19043560; 19050632; 19074885; 19120480; 19122645; 19167431; 19247692; 19260860; 19264973; 19273470; 19327158; 19337385; 19401779; 19406482; 19423540; 19538217; 19570976; 19587002; 19660916; 19667203; 19723304; 19818630; 19843337; 19882212; 19898471; 19913121; 20002790; 20007577; 20039881; 20124104; 20300534; 20384614; 20389019; 20395963; 20403997; 20406964; 20438785; 20453000; 20470879; 20485444; 20519512; 20595247; 20628086; 20646321; 20713621; 20818820; 20844241; 20846183; 21042538; 21048031; 21097508; 21241317; 21263023; 21310790; 21330608; 21342182; 21677137; 21722177; 21739538; 21745515; 21757725; 21768114; 21864388; 21924184; 21978001; 21988832; 22062585; 22143988; 22218461; 22507623; 22563200; 22763410; 22795647; 22848741; 22870324; 22902391; 23062636; 23136938; 23182460; 23275338; 23300079; 23353647; 23382681; 23460743; 23711367; 23712977; 23740944; 23839082; 23888881; 23935490
description: nucleotide-binding oligomerization domain containing 1
database cross reference: Ensembl:ENSG00000106100
database cross reference: HGNC:16390
database cross reference: HPRD:05815
database cross reference: MIM:605980
database cross reference: Vega:OTTHUMG00000023923

GNB2L1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: Gnb2-rs1
alternative term: H12.3
alternative term: HLC-7
alternative term: PIG21
alternative term: RACK1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GNB2L1
full name from nomenclature authority: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
NCBI GeneID: 10399
NCBI LocusTag: HLC7
gene map location: 5q35.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001891 (EC: IDA); GO_0001934 (EC: IDA, PMID: 11312657); GO_0005080 (EC: IDA, PMID: 11279199); GO_0005102 (EC: NAS, PMID: 12809483); GO_0005515 (EC: IPI, PMID: 10849009); GO_0005634 (EC: IDA, PMID: 10849009); GO_0005737 (EC: IDA, PMID: 10849009); GO_0005739 (EC: IMP, PMID: 19767770); GO_0005829 (EC: IMP, PMID: 19767770); GO_0005856 (EC: IEA); GO_0006919 (EC: IMP, PMID: 19767770); GO_0007049 (EC: IEA); GO_0007369 (EC: IEA); GO_0008200 (EC: ISS); GO_0008656 (EC: IMP, PMID: 19767770); GO_0015935 (EC: ISS); GO_0016032 (EC: IEA); GO_0017148 (EC: ISS); GO_0019899 (EC: IPI); GO_0019903 (EC: IPI, PMID: 11278757); GO_0030178 (EC: ISS); GO_0030292 (EC: IDA, PMID: 9584165); GO_0030308 (EC: IDA, PMID: 9584165); GO_0030335 (EC: IDA); GO_0030425 (EC: ISS); GO_0030496 (EC: IDA, PMID: 15166316); GO_0030822 (EC: IMP); GO_0030971 (EC: IDA, PMID: 9584165); GO_0032436 (EC: IDA, PMID: 19785988); GO_0032464 (EC: IDA); GO_0032464 (EC: IMP, PMID: 19767770); GO_0032880 (EC: ISS); GO_0032947 (EC: TAS); GO_0042169 (EC: IDA, PMID: 11279199); GO_0043025 (EC: ISS); GO_0043065 (EC: IDA); GO_0043065 (EC: IMP, PMID: 19767770); GO_0043204 (EC: IEA); GO_0043547 (EC: IDA); GO_0044822 (EC: IDA); GO_0048471 (EC: IDA, PMID: 11279199); GO_0048511 (EC: IEA); GO_0050765 (EC: IMP); GO_0051302 (EC: ISS); GO_0051343 (EC: IMP); GO_0051726 (EC: IDA, PMID: 9584165); GO_0051898 (EC: IMP, PMID: 19767770); GO_0051901 (EC: IMP, PMID: 19767770); GO_0061099 (EC: IDA, PMID: 9584165); GO_0070062 (EC: IDA, PMID: 19056867); GO_0090003 (EC: IEA); GO_2000114 (EC: ISS); GO_2000543 (EC: ISS); GO_2001244 (EC: IMP, PMID: 19767770)
has PubMed association: PMID: 1326322; 1602151; 2499885; 7782277; 7821789; 8125298; 8290562; 8302854; 9442085; 9584165; 9765275; 9876970; 10329691; 10480917; 10490850; 10708423; 10820259; 10849009; 11046044; 11076863; 11256614; 11278757; 11279199; 11301323; 11312657; 11350068; 11516626; 11709417; 11733189; 11801604; 11824616; 11884618; 11934885; 11943848; 11956211; 11964397; 12193273; 12359736; 12388589; 12391233; 12400005; 12435334; 12477932; 12521306; 12524444; 12692135; 12761493; 12809483; 12884273; 12958311; 12960323; 14559993; 14654845; 14699138; 14702039; 14724252; 14963031; 14966116; 15159402; 15166316; 15202772; 15252133; 15254245; 15467455; 15489334; 15489336; 15548575; 15577927; 15592455; 15596539; 15611085; 15952740; 15955845; 16009940; 16061178; 16169070; 16189514; 16196087; 16212959; 16236267; 16381901; 16382134; 16449650; 16455055; 16689683; 16702786; 16705158; 16757810; 16849317; 16920332; 16997272; 17072338; 17108144; 17110338; 17166942; 17201176; 17244529; 17269730; 17361105; 17361185; 17409124; 17500595; 17515463; 17558393; 17574549; 17718421; 17875644; 17875659; 17900862; 17936896; 17965024; 18057008; 18088317; 18172692; 18420585; 18442364; 18557705; 18567578; 18596232; 18621736; 18624398; 18755685; 18781797; 18954305; 19000751; 19010305; 19056867; 19251694; 19372219; 19423701; 19451233; 19454010; 19616115; 19738201; 19767770; 19785988; 19855191; 19892429; 19917775; 19946739; 19966859; 20020495; 20020773; 20099848; 20103773; 20360068; 20410295; 20499158; 20529362; 20639865; 20689807; 20697360; 20736409; 20819076; 20858845; 20871634; 20874815; 20875397; 20976005; 21139048; 21145461; 21146485; 21212275; 21282530; 21319273; 21347310; 21525958; 21685945; 21738584; 21756811; 21848913; 21860413; 21890473; 21900206; 21906983; 21935400; 21963094; 21987572; 21988832; 22007921; 22053931; 22065575; 22069327; 22174317; 22174419; 22207523; 22240482; 22246531; 22262830; 22268729; 22289149; 22314363; 22334666; 22365833; 22378065; 22505724; 22538239; 22547057; 22558273; 22586326; 225921…
description: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
database cross reference: Ensembl:ENSG00000204628
database cross reference: HGNC:4399
database cross reference: HPRD:01503
database cross reference: MIM:176981
database cross reference: Vega:OTTHUMG00000163380

TOMM40
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: C19orf1
alternative term: D19S1177E
alternative term: PER-EC1
alternative term: PEREC1
alternative term: TOM40
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TOMM40
full name from nomenclature authority: translocase of outer mitochondrial membrane 40 homolog (yeast)
NCBI GeneID: 10452
gene map location: 19q13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005739 (EC: IMP, Qualifier: NOT, PMID: 11745481); GO_0005742 (EC: IDA, PMID: 12198123); GO_0006626 (EC: IMP, PMID: 15644312); GO_0006626 (EC: TAS); GO_0006811 (EC: IEA); GO_0008320 (EC: ISS); GO_0008320 (EC: TAS, PMID: 15644312); GO_0015288 (EC: IEA); GO_0016021 (EC: IDA, PMID: 15644312); GO_0031307 (EC: ISS, PMID: 10980201); GO_0044267 (EC: TAS); GO_0046930 (EC: IEA); GO_0071806 (EC: ISS); GO_0071806 (EC: TAS, PMID: 15644312)
has PubMed association: PMID: 10520737; 10980201; 11745481; 12198123; 12477932; 15342556; 15489334; 15644312; 16495475; 17635912; 17672918; 18095154; 18430993; 18439552; 18823527; 19060910; 19060911; 19125160; 19197348; 19668339; 19734902; 19734903; 19913121; 20029386; 20061627; 20100581; 20370913; 20460622; 20467438; 20628086; 20877624; 20885792; 20932310; 21123754; 21139048; 21418511; 21627779; 21717124; 21720235; 21784354; 21803501; 21820212; 21825236; 21835183; 21890473; 21906983; 21909109; 21943158; 21963094; 21983493; 22005931; 22008263; 22054870; 22089642; 22190034; 22280891; 22359560; 22399527; 22472643; 22596268; 22694956; 22710912; 22832961; 22863908; 22898894; 22939629; 22939635; 23102119; 23182705; 23183136; 23207651; 23234877; 23288655; 23326517; 23419831; 23435269; 23522842; 23546992; 23562540; 23565137; 23626796; 23726366; 23844046; 24146538; 24149440
description: translocase of outer mitochondrial membrane 40 homolog (yeast)
database cross reference: Ensembl:ENSG00000130204
database cross reference: HGNC:18001
database cross reference: HPRD:16274
database cross reference: MIM:608061
database cross reference: Vega:OTTHUMG00000180842

CIB1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CIB
alternative term: CIBP
alternative term: KIP1
alternative term: PRKDCIP
alternative term: SIP2-28
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CIB1
full name from nomenclature authority: calcium and integrin binding 1 (calmyrin)
NCBI GeneID: 10519
gene map location: 15q25.3-q26
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001525 (EC: IEA); GO_0001933 (EC: ISS); GO_0001934 (EC: ISS); GO_0001954 (EC: ISS); GO_0002931 (EC: ISS); GO_0005509 (EC: IMP, PMID: 15475008); GO_0005515 (EC: IPI, PMID: 10366599); GO_0005634 (EC: IDA); GO_0005654 (EC: IMP, PMID: 10366599); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA, PMID: 11756406); GO_0005737 (EC: IMP, PMID: 10366599); GO_0005783 (EC: IMP, PMID: 10366599); GO_0005794 (EC: IEA); GO_0005813 (EC: IDA); GO_0005886 (EC: IDA); GO_0006302 (EC: TAS, PMID: 9372844); GO_0006915 (EC: IMP, PMID: 10366599); GO_0006974 (EC: IDA, PMID: 12011095); GO_0007026 (EC: IDA); GO_0007113 (EC: IDA); GO_0007155 (EC: IEA); GO_0007286 (EC: ISS); GO_0008284 (EC: ISS); GO_0008285 (EC: IMP); GO_0010977 (EC: IDA); GO_0016020 (EC: IDA, PMID: 10366599); GO_0016324 (EC: IEA); GO_0017016 (EC: IPI, PMID: 11756406); GO_0030027 (EC: IDA); GO_0030220 (EC: ISS); GO_0030307 (EC: ISS); GO_0030335 (EC: ISS); GO_0030426 (EC: IDA); GO_0031122 (EC: IMP); GO_0032433 (EC: IDA); GO_0032587 (EC: IEA); GO_0033630 (EC: IDA, PMID: 11756406); GO_0038163 (EC: ISS); GO_0042127 (EC: IMP); GO_0042383 (EC: IDA); GO_0043005 (EC: IDA); GO_0043025 (EC: IDA); GO_0043066 (EC: IMP, PMID: 19854831); GO_0043495 (EC: IGI); GO_0044325 (EC: IEA); GO_0045653 (EC: ISS); GO_0048471 (EC: IDA, PMID: 11756406); GO_0048554 (EC: ISS); GO_0051092 (EC: IMP, PMID: 19854831); GO_0051301 (EC: IEA); GO_0051302 (EC: IMP); GO_0051898 (EC: ISS); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070374 (EC: ISS); GO_0070886 (EC: IDA); GO_0071356 (EC: IMP, PMID: 19854831); GO_0071363 (EC: ISS); GO_0071902 (EC: ISS); GO_0071944 (EC: IDA, PMID: 11756406); GO_0090004 (EC: IGI); GO_0090050 (EC: ISS); GO_0090314 (EC: IMP, PMID: 19854831); GO_0097191 (EC: TAS, PMID: 19805025); GO_1900026 (EC: IDA, PMID: 11756406); GO_1901313 (EC: ISS); GO_1990090 (EC: IDA); GO_2000256 (EC: ISS)
has PubMed association: PMID: 9030514; 9372844; 9852683; 10366599; 10523297; 10822252; 10826701; 11039900; 11756406; 11856312; 11997098; 12011095; 12023286; 12477932; 12651910; 12714504; 12881299; 14992593; 15190070; 15203218; 15231747; 15475008; 15489334; 15574431; 15604093; 15685448; 15885068; 15933764; 16061695; 16418530; 16582881; 16723353; 16825200; 17516631; 18627437; 18989529; 19056867; 19388079; 19805025; 19854831; 19913121; 19923078; 20473878; 20628086; 20951827; 20959453; 21215777; 21388953; 21748785; 21857112; 21890473; 21906983; 21963094; 21988832; 22505724; 22547769; 22779914; 22964641; 23503467; 24011356; 24250222
description: calcium and integrin binding 1 (calmyrin)
database cross reference: HGNC:16920
database cross reference: HPRD:03800
database cross reference: MIM:602293

KAT5
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ESA1
alternative term: HTATIP
alternative term: HTATIP1
alternative term: PLIP
alternative term: TIP
alternative term: TIP60
alternative term: ZC2HC5
alternative term: cPLA2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: KAT5
full name from nomenclature authority: K(lysine) acetyltransferase 5
NCBI GeneID: 10524
gene map location: 11q13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IMP, PMID: 17360565); GO_0000812 (EC: IDA); GO_0003713 (EC: IDA, PMID: 14966270); GO_0003713 (EC: TAS, PMID: 17360565); GO_0004402 (EC: IDA, PMID: 18397884); GO_0004402 (EC: IDA, Qualifier: contributes_to, PMID: 14966270); GO_0004402 (EC: IMP, PMID: 17996965); GO_0005515 (EC: IPI, PMID: 15383276); GO_0005634 (EC: IDA); GO_0005654 (EC: TAS); GO_0005667 (EC: IEA); GO_0005730 (EC: IDA, PMID: 16387653); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005829 (EC: IEA); GO_0006302 (EC: IMP, PMID: 10966108); GO_0006325 (EC: TAS); GO_0006351 (EC: IEA); GO_0006978 (EC: IDA, PMID: 14966270); GO_0010212 (EC: IDA, PMID: 18397884); GO_0016032 (EC: IEA); GO_0016573 (EC: IDA, PMID: 10966108); GO_0030521 (EC: NAS, PMID: 15572661); GO_0032403 (EC: IEA); GO_0032703 (EC: IDA, PMID: 17360565); GO_0032777 (EC: IDA, PMID: 14966270); GO_0035267 (EC: IDA, PMID: 10966108); GO_0040008 (EC: IEA); GO_0043161 (EC: IMP, PMID: 18397884); GO_0045892 (EC: IDA, PMID: 17360565); GO_0045893 (EC: IDA, PMID: 14966270); GO_0045893 (EC: NAS, PMID: 15572661); GO_0045944 (EC: IEA); GO_0046872 (EC: IEA); GO_0048471 (EC: IEA); GO_0050681 (EC: NAS, PMID: 15572661); GO_0070491 (EC: IPI, PMID: 17360565)
has PubMed association: PMID: 8125298; 8607265; 8889548; 9388189; 10096020; 10362352; 10364196; 10393559; 10486269; 10720489; 10966108; 11111051; 11262386; 11275565; 11416127; 11441186; 11509179; 11591700; 11839798; 11927554; 11994312; 12032152; 12036595; 12150997; 12154097; 12464179; 12468530; 12477932; 12551922; 12737628; 12776177; 12801643; 12888553; 12963728; 14699153; 14701804; 14966270; 15005629; 15016909; 15017382; 15042092; 15044485; 15121871; 15196461; 15310756; 15331662; 15383276; 15474031; 15489334; 15502158; 15572661; 15572685; 15591049; 15647280; 15829968; 15985650; 16001085; 16141325; 16169070; 16189514; 16223726; 16287840; 16341205; 16344560; 16387653; 16455055; 16469706; 16501607; 16601686; 16603769; 16698308; 16705183; 16835243; 16844118; 17110330; 17126496; 17189186; 17308053; 17360565; 17368826; 17406968; 17418098; 17551969; 17573780; 17636029; 17704809; 17709392; 17728759; 17827213; 17851107; 17967892; 17980166; 17996965; 18003922; 18029348; 18087039; 18096664; 18218781; 18239623; 18263878; 18264029; 18280244; 18285460; 18397884; 18406329; 18414493; 18451177; 18458078; 18485870; 18499675; 18577246; 18625847; 18985155; 19048121; 19114310; 19150978; 19169279; 19176879; 19308289; 19716452; 19783983; 19800870; 19819149; 19846935; 19895790; 19909775; 19938016; 20070254; 20100829; 20159953; 20224553; 20332121; 20351180; 20383146; 20507282; 20542002; 20796290; 20946988; 21045206; 21157427; 21273583; 21320689; 21320693; 21463657; 21574959; 21658600; 21668587; 21699783; 21704408; 21781306; 21832049; 21900206; 21906983; 21936881; 21963094; 21988832; 22018239; 22071692; 22081016; 22084066; 22094252; 22100137; 22110127; 22159227; 22249179; 22354990; 22379092; 22391203; 22398289; 22467210; 22539723; 22573825; 22586264; 22673729; 22902274; 22939624; 22939629; 23044042; 23046361; 23056207; 23178490; 23238566; 23297341; 23555077; 23576563; 23609452; 23677994; 23685072; 23708966; 23775119; 23777805; 23857583
description: K(lysine) acetyltransferase 5
database cross reference: Ensembl:ENSG00000172977
database cross reference: HGNC:5275
database cross reference: HPRD:03245
database cross reference: MIM:601409
database cross reference: Vega:OTTHUMG00000166617

ATG7
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APG7-LIKE
alternative term: APG7L
alternative term: GSA7
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ATG7
full name from nomenclature authority: autophagy related 7
NCBI GeneID: 10533
gene map location: 3p25.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000407 (EC: IEA); GO_0001889 (EC: IEA); GO_0004839 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11096062); GO_0005737 (EC: TAS, PMID: 10233149); GO_0005930 (EC: ISS); GO_0006464 (EC: TAS, PMID: 10233149); GO_0006497 (EC: IDA, PMID: 12890687); GO_0006520 (EC: IEA); GO_0006914 (EC: IEA); GO_0006996 (EC: IEA); GO_0007628 (EC: IEA); GO_0009791 (EC: IEA); GO_0015031 (EC: IEA); GO_0016239 (EC: IMP); GO_0019778 (EC: ISS); GO_0021680 (EC: IEA); GO_0021860 (EC: IEA); GO_0021955 (EC: IEA); GO_0021987 (EC: IEA); GO_0030163 (EC: IEA); GO_0031396 (EC: IEA); GO_0031401 (EC: IDA, PMID: 12890687); GO_0032446 (EC: IEA); GO_0042594 (EC: IEA); GO_0042803 (EC: IDA, PMID: 11096062); GO_0043066 (EC: IEA); GO_0050877 (EC: IEA); GO_0055013 (EC: IEA); GO_0061025 (EC: TAS, PMID: 10233149)
has PubMed association: PMID: 10233149; 11096062; 11825910; 11890701; 12477932; 12482611; 12890687; 15342556; 15489334; 16303743; 16303767; 16344560; 16704426; 18029348; 18187620; 18296641; 18688877; 19124466; 19148225; 19635843; 19881538; 20083906; 20195357; 20379614; 20543840; 20562859; 20697744; 21139048; 21274862; 21655094; 21832049; 21903422; 21963094; 22170151; 22499945; 22622204; 22674379; 22863883; 22927446; 23295909; 23386620; 23527187; 23640897; 23824909; 23894380; 24068947; 24250222
description: autophagy related 7
database cross reference: Ensembl:ENSG00000197548
database cross reference: HGNC:16935
database cross reference: HPRD:12293
database cross reference: MIM:608760
database cross reference: Vega:OTTHUMG00000129740

IFI44
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MTAP44
alternative term: TLDC5
alternative term: p44
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IFI44
full name from nomenclature authority: interferon-induced protein 44
NCBI GeneID: 10561
gene map location: 1p31.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005737 (EC: IEA); GO_0009615 (EC: TAS, PMID: 7925411)
has PubMed association: PMID: 7925411; 12477932; 12539042; 15489334; 16886895; 17207965; 17784819; 18029348; 18953482; 19460752; 20237496; 21963094; 21987572; 22896602; 23453885
description: interferon-induced protein 44
database cross reference: Ensembl:ENSG00000137965
database cross reference: HGNC:16938
database cross reference: HPRD:09998
database cross reference: MIM:610468
database cross reference: Vega:OTTHUMG00000009723

PMVK
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HUMPMKI
alternative term: PMK
alternative term: PMKA
alternative term: PMKASE
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PMVK
full name from nomenclature authority: phosphomevalonate kinase
NCBI GeneID: 10654
NCBI LocusTag: RP11-307C12.5
gene map location: 1q22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004631 (EC: IDA, PMID: 14680974); GO_0005524 (EC: IDA, PMID: 16519518); GO_0005777 (EC: IDA, PMID: 10191291); GO_0005829 (EC: IDA, PMID: 14729858); GO_0005829 (EC: TAS); GO_0006695 (EC: IDA, PMID: 8663599); GO_0006695 (EC: TAS); GO_0016126 (EC: IDA, PMID: 16519518); GO_0019287 (EC: IEA); GO_0044281 (EC: TAS); GO_0070062 (EC: IDA, PMID: 19056867); GO_0070723 (EC: IEP, PMID: 10191291)
has PubMed association: PMID: 8188698; 8663599; 10191291; 12477932; 14680974; 14729858; 15489334; 16519518; 17180682; 17353931; 17902708; 18618710; 18660489; 18798562; 19056867; 19913121; 20628086; 21139048; 21890473; 21906983; 22544366; 22939629; 23000965; 23535732
description: phosphomevalonate kinase
database cross reference: Ensembl:ENSG00000163344
database cross reference: HGNC:9141
database cross reference: HPRD:07404
database cross reference: MIM:607622
database cross reference: Vega:OTTHUMG00000037415

CELF1
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BRUNOL2
alternative term: CUG-BP
alternative term: CUGBP
alternative term: CUGBP1
alternative term: EDEN-BP
alternative term: NAB50
alternative term: NAPOR
alternative term: hNab50
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CELF1
full name from nomenclature authority: CUGBP, Elav-like family member 1
NCBI GeneID: 10658
gene map location: 11p11
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000166 (EC: IEA); GO_0000900 (EC: NAS, PMID: 10893231); GO_0003723 (EC: IDA, PMID: 16946708); GO_0003729 (EC: IDA, PMID: 14726956); GO_0005515 (EC: IPI, PMID: 16946708); GO_0005634 (EC: IDA); GO_0005634 (EC: NAS, PMID: 10893231); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IEA); GO_0006376 (EC: ISS); GO_0006397 (EC: TAS, PMID: 8948631); GO_0007281 (EC: NAS, PMID: 10893231); GO_0007286 (EC: IEA); GO_0009790 (EC: NAS, PMID: 10893231); GO_0016246 (EC: NAS, PMID: 10893231); GO_0017148 (EC: NAS, PMID: 10893231); GO_0030529 (EC: NAS, PMID: 10893231); GO_0031369 (EC: IEA); GO_0040018 (EC: IEA); GO_0042835 (EC: IDA, PMID: 10893231); GO_0043484 (EC: IDA, PMID: 16946708); GO_0044822 (EC: IDA)
has PubMed association: PMID: 8789448; 8912635; 8948631; 9371827; 10446244; 10536163; 10893231; 11124939; 11158314; 11564876; 11686919; 12477932; 12799066; 14657503; 14702039; 14726956; 14759258; 15082764; 15099703; 15489334; 15546872; 15756469; 16169070; 16341674; 16344560; 16601207; 16946708; 17531403; 17854664; 17936705; 18039683; 18164289; 18243120; 18570922; 19047369; 19106619; 19322201; 19471022; 19553194; 19615732; 20020773; 20051426; 20227387; 20547756; 20603324; 20935630; 20947024; 21139048; 21508681; 21637851; 21832049; 21890473; 21906983; 21963094; 22053931; 22117072; 22355723; 22365833; 22505724; 22646166; 22982313; 23000965; 23155001; 23324604; 24457600
description: CUGBP, Elav-like family member 1
database cross reference: Ensembl:ENSG00000149187
database cross reference: HGNC:2549
database cross reference: HPRD:03046
database cross reference: MIM:601074

NRG3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HRG3
alternative term: pro-NRG3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NRG3
full name from nomenclature authority: neuregulin 3
NCBI GeneID: 10718
gene map location: 10q22-q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001558 (EC: NAS, PMID: 9275162); GO_0005576 (EC: NAS, PMID: 9275162); GO_0005887 (EC: NAS, PMID: 9275162); GO_0007171 (EC: NAS, PMID: 9275162); GO_0007389 (EC: IEA); GO_0008083 (EC: NAS, PMID: 9275162); GO_0030297 (EC: NAS, PMID: 9275162); GO_0030971 (EC: NAS, PMID: 9275162); GO_0060596 (EC: IEA)
has PubMed association: PMID: 9275162; 11032326; 12477932; 14702039; 15164054; 16344560; 16478787; 17598910; 17880691; 17962208; 18519826; 18521091; 18708184; 18846501; 19086053; 19118813; 19776380; 19913121; 20379614; 20398908; 20548296; 20628086; 20713722; 21248748; 21348951; 21705454; 21762460; 22589734; 22831755; 22981155; 23251661; 23315268; 23382691; 23393555; 24431462
description: neuregulin 3
database cross reference: Ensembl:ENSG00000185737
database cross reference: HGNC:7999
database cross reference: HPRD:16115
database cross reference: MIM:605533
database cross reference: Vega:OTTHUMG00000018626

CCR9
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CC-CKR-9
alternative term: CDw199
alternative term: GPR-9-6
alternative term: GPR28
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCR9
full name from nomenclature authority: chemokine (C-C motif) receptor 9
NCBI GeneID: 10803
gene map location: 3p21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004950 (EC: TAS, PMID: 10229797); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 10229797); GO_0006935 (EC: IEA); GO_0006955 (EC: IEA); GO_0006968 (EC: TAS, PMID: 10544196); GO_0007186 (EC: TAS, PMID: 10544196); GO_0007204 (EC: TAS, PMID: 10229797); GO_0016493 (EC: IEA); GO_0070098 (EC: TAS, PMID: 10229797)
has PubMed association: PMID: 2834384; 10229797; 10498628; 10544196; 10602049; 10640743; 10702689; 10974041; 11046037; 12477932; 12816994; 14559839; 15489334; 15623660; 15717282; 16344560; 17205512; 17570212; 18240029; 18245518; 18245522; 18577758; 19423540; 19525985; 19756884; 20036838; 20056178; 20081876; 20190752; 20406964; 20438785; 20738854; 20947433; 21075690; 21344163; 21511186; 21637913; 21984373; 23326330
description: chemokine (C-C motif) receptor 9
database cross reference: Ensembl:ENSG00000173585
database cross reference: HGNC:1610
database cross reference: HPRD:09200
database cross reference: MIM:604738
database cross reference: Vega:OTTHUMG00000133450

FERMT2
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: KIND2
alternative term: MIG2
alternative term: PLEKHC1
alternative term: UNC112
alternative term: UNC112B
alternative term: mig-2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: FERMT2
full name from nomenclature authority: fermitin family member 2
NCBI GeneID: 10979
gene map location: 14q22.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 14
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001725 (EC: IEA); GO_0005515 (EC: IPI); GO_0005547 (EC: IDA); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0005925 (EC: IDA); GO_0005938 (EC: IEA); GO_0007160 (EC: IMP); GO_0007160 (EC: ISS); GO_0007179 (EC: IMP); GO_0007229 (EC: IMP); GO_0008360 (EC: IEA); GO_0009986 (EC: IEA); GO_0016055 (EC: IMP); GO_0031234 (EC: IDA); GO_0031258 (EC: IEA); GO_0031674 (EC: IEA); GO_0031941 (EC: IEA); GO_0033622 (EC: IMP); GO_0034329 (EC: TAS); GO_0034446 (EC: ISS); GO_0048041 (EC: ISS); GO_0072657 (EC: ISS)
has PubMed association: PMID: 8175911; 12477932; 12508121; 12679033; 12697302; 12789646; 14702039; 14745725; 15489334; 17081983; 18029348; 18458155; 18528435; 18781797; 19854292; 20127858; 20702409; 20861856; 21139048; 21325030; 21356350; 21624607; 21636915; 21832049; 21890473; 21922223; 22030399; 22056622; 22078565; 22391155; 22648415; 22699938; 22863883; 22939629; 23000965; 23151599; 23209705; 23211537; 23337877; 23383273; 23483548; 23508013; 23535732; 23667531; 23723426; 23857544
description: fermitin family member 2
database cross reference: Ensembl:ENSG00000073712
database cross reference: HGNC:15767
database cross reference: HPRD:06374
database cross reference: MIM:607746
database cross reference: Vega:OTTHUMG00000140309

NUDT6
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ASFGF2
alternative term: FGF-AS
alternative term: FGF2AS
alternative term: GFG-1
alternative term: GFG1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NUDT6
full name from nomenclature authority: nudix (nucleoside diphosphate linked moiety X)-type motif 6
NCBI GeneID: 11162
gene map location: 4q26
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005575 (EC: ND); GO_0005634 (EC: IEA); GO_0005739 (EC: IEA); GO_0008083 (EC: TAS, PMID: 7984147); GO_0008150 (EC: ND); GO_0016787 (EC: IEA)
has PubMed association: PMID: 7984147; 7999082; 9406864; 10022609; 11266510; 11801566; 12477932; 15247275; 15489334; 16712791; 17203973; 17569023; 17681892; 18401527; 19054571; 19416273; 19423540; 19913121; 20406964; 20438785; 20628086; 20800603; 21139048; 21890473
description: nudix (nucleoside diphosphate linked moiety X)-type motif 6
database cross reference: Ensembl:ENSG00000170917
database cross reference: HGNC:8053
database cross reference: HPRD:05880
database cross reference: MIM:606261
database cross reference: Vega:OTTHUMG00000039507

WIF1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: WIF-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: WIF1
full name from nomenclature authority: WNT inhibitory factor 1
NCBI GeneID: 11197
NCBI LocusTag: UNQ191/PRO217
gene map location: 12q14.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 19188438); GO_0005576 (EC: IEA); GO_0007165 (EC: NAS, PMID: 10201374); GO_0007275 (EC: IEA); GO_0016055 (EC: IEA); GO_0045600 (EC: IEA)
has PubMed association: PMID: 10201374; 12477932; 12975309; 15351726; 15377999; 15389810; 15489334; 15735743; 16007117; 16427602; 16428476; 16476441; 16516163; 16525492; 16609023; 17012225; 17094650; 17171686; 17384664; 18005197; 18079202; 18093228; 18256869; 18701434; 19054571; 19085002; 19174556; 19188438; 19307728; 19453261; 19496188; 19528461; 19570204; 19690140; 19773381; 19787276; 19885602; 19887605; 19926868; 20066439; 20119713; 20197388; 20334650; 20364027; 20376066; 20395289; 20421722; 20573255; 20596629; 20697356; 20811686; 20844743; 20874008; 21052890; 21642372; 21743455; 21819494; 21873353; 21928342; 21988832; 22002305; 22315090; 22333550; 22504421; 22901505; 22951645; 22951732; 22986341; 23193918; 23316316; 23328978; 23358094; 23417837; 23686431; 23746174; 23939044; 24118380; 24289328
description: WNT inhibitory factor 1
database cross reference: Ensembl:ENSG00000156076
database cross reference: HGNC:18081
database cross reference: HPRD:05541
database cross reference: MIM:605186
database cross reference: Vega:OTTHUMG00000168832

NLRP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CARD7
alternative term: CIDED
alternative term: CLR17.1
alternative term: DEFCAP
alternative term: DEFCAP-L/S
alternative term: NAC
alternative term: NALP1
alternative term: PP1044
alternative term: SLEV1
alternative term: VAMAS1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NLRP1
full name from nomenclature authority: NLR family, pyrin domain containing 1
NCBI GeneID: 22861
gene map location: 17p13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 11472070); GO_0005524 (EC: IDA, PMID: 15212762); GO_0005622 (EC: IC, PMID: 11076957); GO_0005634 (EC: IDA, PMID: 17164409); GO_0005829 (EC: TAS); GO_0006915 (EC: NAS, PMID: 11076957); GO_0006919 (EC: IDA, PMID: 15212762); GO_0006919 (EC: NAS, PMID: 11076957); GO_0008656 (EC: NAS, PMID: 11076957); GO_0019899 (EC: IPI, PMID: 11076957); GO_0019904 (EC: IPI, PMID: 16575408); GO_0032495 (EC: ISS); GO_0035872 (EC: TAS); GO_0042742 (EC: ISS); GO_0045087 (EC: TAS); GO_0050718 (EC: ISS); GO_0050727 (EC: IC, PMID: 15212762); GO_0051402 (EC: IDA, PMID: 15212762); GO_0072558 (EC: IDA, PMID: 12191486); GO_0072558 (EC: TAS)
has PubMed association: PMID: 8619474; 8781126; 9110174; 10231032; 11076957; 11113115; 11250163; 11270363; 11472070; 11592035; 12191486; 12477932; 12563287; 14527388; 14691733; 14702039; 15107016; 15174051; 15212762; 15749123; 16575408; 17164409; 17377159; 17418785; 17620097; 17637824; 18263805; 18348116; 18854154; 18946481; 19001869; 19074885; 19120479; 19223160; 19337385; 19727120; 19913121; 20152874; 20370570; 20379614; 20403135; 20502346; 20574744; 20628086; 20697295; 20800603; 21098108; 21149496; 21245836; 21252346; 21331694; 21376416; 21946017; 21976003; 22087307; 22117610; 22227487; 22235789; 22507623; 22524199; 22665479; 23053059; 23253924; 23349227; 23374100; 23380025; 23382179; 23508996; 23563199; 23940760; 24008734
description: NLR family, pyrin domain containing 1
database cross reference: Ensembl:ENSG00000091592
database cross reference: HGNC:14374
database cross reference: HPRD:07364
database cross reference: MIM:606636
database cross reference: Vega:OTTHUMG00000132419

CD93
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: C1QR1
alternative term: C1qR(P)
alternative term: C1qRP
alternative term: CDw93
alternative term: ECSM3
alternative term: MXRA4
alternative term: dJ737E23.1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CD93
full name from nomenclature authority: CD93 molecule
NCBI GeneID: 22918
gene map location: 20p11.21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001849 (EC: IDA, PMID: 11781389); GO_0004872 (EC: NAS, PMID: 9047234); GO_0005509 (EC: IEA); GO_0005515 (EC: IPI, PMID: 15459234); GO_0005886 (EC: IDA); GO_0006909 (EC: NAS, PMID: 10092817); GO_0009986 (EC: IEA); GO_0016021 (EC: IC, PMID: 9047234); GO_0016023 (EC: IEA); GO_0016032 (EC: IEA); GO_0016337 (EC: IDA, PMID: 11994479); GO_0030246 (EC: IEA); GO_0042116 (EC: NAS, PMID: 9047234)
has PubMed association: PMID: 1377218; 2212670; 8062452; 8710908; 9047234; 9136074; 9469455; 9476117; 9777410; 10092817; 10430665; 10648005; 11076863; 11086025; 11204562; 11256614; 11780052; 11781389; 11994479; 12140365; 12213329; 12477932; 12891708; 14702039; 15459234; 15489334; 15489336; 15819698; 16381901; 17474147; 18094537; 18599554; 18834607; 19166692; 19344414; 19372141; 19423540; 19796797; 20237496; 20406964; 20438785; 20512406; 21332844; 21768350; 21988832; 22206251; 23251661; 23268996; 23272129; 23651874; 24124411
description: CD93 molecule
database cross reference: Ensembl:ENSG00000125810
database cross reference: HGNC:15855
database cross reference: HPRD:00396
database cross reference: MIM:120577
database cross reference: Vega:OTTHUMG00000032058

MSRB2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CBS-1
alternative term: CBS1
alternative term: MSRB
alternative term: PILB
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MSRB2
full name from nomenclature authority: methionine sulfoxide reductase B2
NCBI GeneID: 22921
NCBI LocusTag: CGI-131
gene map location: 10p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003700 (EC: TAS, PMID: 10375640); GO_0003779 (EC: ISS); GO_0005739 (EC: ISS, PMID: 14699060); GO_0006355 (EC: TAS, PMID: 10375640); GO_0006979 (EC: IEA); GO_0008270 (EC: ISS, PMID: 14699060); GO_0030041 (EC: ISS); GO_0030091 (EC: ISS, PMID: 14699060); GO_0033743 (EC: ISS)
has PubMed association: PMID: 8749308; 10375640; 10810093; 12220640; 12477932; 14699060; 14759519; 14980072; 16385451; 16480945; 17601350; 17943184; 18424444; 18977241; 19237503; 19322201; 19542914; 20877624; 22145905; 22634633; 22939629; 23251661
description: methionine sulfoxide reductase B2
database cross reference: Ensembl:ENSG00000148450
database cross reference: HGNC:17061
database cross reference: HPRD:17606
database cross reference: MIM:613782
database cross reference: Vega:OTTHUMG00000017812

ATF6
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ATF6A
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ATF6
full name from nomenclature authority: activating transcription factor 6
NCBI GeneID: 22926
gene map location: 1q22-q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: TAS); GO_0003700 (EC: IEA); GO_0003713 (EC: TAS, PMID: 10866666); GO_0005515 (EC: IPI, PMID: 16469704); GO_0005634 (EC: TAS, PMID: 10564271); GO_0005635 (EC: TAS, PMID: 10866666); GO_0005654 (EC: TAS); GO_0005789 (EC: TAS); GO_0006351 (EC: IEA); GO_0006357 (EC: TAS, PMID: 10564271); GO_0006457 (EC: TAS, PMID: 10564271); GO_0006950 (EC: TAS, PMID: 10866666); GO_0006987 (EC: TAS); GO_0006990 (EC: TAS, PMID: 9837962); GO_0007165 (EC: TAS, PMID: 9271374); GO_0016021 (EC: IEA); GO_0030968 (EC: TAS, PMID: 19816510); GO_0043565 (EC: IEA); GO_0044267 (EC: TAS)
has PubMed association: PMID: 2516827; 8889548; 9271374; 9837962; 10564271; 10866666; 11158310; 11163209; 11256944; 11287625; 11483355; 11805088; 11821395; 11909875; 12014989; 12076252; 12097557; 12477932; 12713871; 12782636; 12805554; 12949534; 14699159; 14765107; 15063770; 15299016; 15342556; 15489334; 15598891; 15899857; 16196087; 16469704; 16505252; 16710414; 17092596; 17101776; 17327457; 17440018; 17442311; 17522056; 17686766; 18022401; 18635891; 18650380; 18840095; 19122331; 19304306; 19420237; 19667116; 19693772; 19722195; 19723703; 19772629; 19816510; 19822759; 19913121; 20160352; 20219975; 20628086; 20732420; 20800603; 20936779; 21106748; 21131360; 21150130; 21211013; 21329801; 21329806; 21345978; 21355074; 21385877; 21454619; 21521793; 21693764; 21809331; 21832049; 21841196; 21906983; 21963094; 21988832; 22013072; 22102412; 22146569; 22268729; 22354938; 22577136; 22872700; 22917505; 22956602; 23011799; 23037953; 23382691; 23661758; 23864652; 23924739; 24043630
description: activating transcription factor 6
database cross reference: Ensembl:ENSG00000118217
database cross reference: HGNC:791
database cross reference: HPRD:16118
database cross reference: MIM:605537
database cross reference: Vega:OTTHUMG00000023961

SIRT2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SIR2
alternative term: SIR2L
alternative term: SIR2L2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SIRT2
full name from nomenclature authority: sirtuin 2
NCBI GeneID: 22933
gene map location: 19q13
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000183 (EC: NAS, PMID: 11427894); GO_0003950 (EC: TAS, Qualifier: NOT, PMID: 17456799); GO_0005515 (EC: IPI, PMID: 12697818); GO_0005677 (EC: NAS, PMID: 12697818); GO_0005737 (EC: IDA, PMID: 12697818); GO_0005874 (EC: IDA, PMID: 12620231); GO_0006342 (EC: NAS, PMID: 12697818); GO_0006348 (EC: NAS, PMID: 11427894); GO_0006471 (EC: NAS, PMID: 10381378); GO_0006471 (EC: TAS, Qualifier: NOT, PMID: 17456799); GO_0006476 (EC: IDA, PMID: 17172643); GO_0007067 (EC: IEA); GO_0007096 (EC: NAS, PMID: 12697818); GO_0008134 (EC: IPI, PMID: 12887892); GO_0008270 (EC: IDA, PMID: 11427894); GO_0016458 (EC: NAS, PMID: 10381378); GO_0016575 (EC: TAS, PMID: 12697818); GO_0017136 (EC: IDA, PMID: 11427894); GO_0021762 (EC: IEP); GO_0033558 (EC: IDA, PMID: 17172643); GO_0034979 (EC: IDA); GO_0034983 (EC: IDA); GO_0035035 (EC: IPI, PMID: 12887892); GO_0042325 (EC: NAS, PMID: 12697818); GO_0042826 (EC: IPI, PMID: 12620231); GO_0042903 (EC: IDA, PMID: 12620231); GO_0043130 (EC: IDA, PMID: 12697818); GO_0043161 (EC: IMP); GO_0045843 (EC: IDA, PMID: 12887892); GO_0045892 (EC: IDA, PMID: 12887892); GO_0051775 (EC: NAS, PMID: 12887892); GO_0070403 (EC: IDA, PMID: 11427894)
has PubMed association: PMID: 8125298; 8619474; 9110174; 10381378; 10393250; 10873683; 10931946; 11427894; 11483616; 11812793; 12477932; 12620231; 12697818; 12887892; 12963026; 14522900; 14702039; 15126506; 15213244; 15220471; 15274642; 15328540; 15489334; 15719057; 16079181; 16211212; 16247014; 16344560; 16565078; 16648462; 16909107; 17172643; 17353931; 17456799; 17516032; 17708669; 17726514; 18193082; 18249170; 18249187; 18332217; 18722353; 18995842; 19282667; 19801601; 20159555; 20237298; 20378838; 20543840; 20562129; 20849899; 21349544; 21511279; 21726808; 21890473; 22014574; 22053931; 22089141; 22166219; 22302938; 22651940; 22735931; 22796962; 22819792; 22833565; 22857867; 22944623; 23000965; 23175188; 23348706; 23358244; 23382805; 23416275; 23460888; 23468428; 23475622; 23723075; 23806683; 23908241; 24161395; 24183459
description: sirtuin 2
database cross reference: Ensembl:ENSG00000068903
database cross reference: HGNC:10886
database cross reference: HPRD:10377
database cross reference: MIM:604480
database cross reference: Vega:OTTHUMG00000150480

DKK1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DKK-1
alternative term: SK
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: DKK1
full name from nomenclature authority: dickkopf WNT signaling pathway inhibitor 1
NCBI GeneID: 22943
NCBI LocusTag: UNQ492/PRO1008
gene map location: 10q11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IDA); GO_0000122 (EC: ISS); GO_0000904 (EC: IEA); GO_0001706 (EC: IEA); GO_0001707 (EC: IEA); GO_0001942 (EC: IEA); GO_0002090 (EC: IDA, PMID: 17804805); GO_0004871 (EC: TAS, PMID: 10383463); GO_0005515 (EC: IPI, PMID: 11448771); GO_0005615 (EC: IDA, PMID: 11448771); GO_0005886 (EC: IDA, PMID: 16263759); GO_0008083 (EC: TAS, PMID: 10383463); GO_0030326 (EC: IEA); GO_0030514 (EC: IEA); GO_0030900 (EC: IEA); GO_0031333 (EC: IDA, PMID: 11448771); GO_0032526 (EC: IEA); GO_0033137 (EC: IDA); GO_0042662 (EC: IDA); GO_0042663 (EC: IDA); GO_0048019 (EC: IDA); GO_0048642 (EC: IEA); GO_0050750 (EC: IDA, PMID: 16263759); GO_0060325 (EC: IEA); GO_0060394 (EC: IDA); GO_0090082 (EC: ISS); GO_0090090 (EC: IDA, PMID: 11448771); GO_0090090 (EC: IGI, PMID: 18166153); GO_0090244 (EC: IEA); GO_1900116 (EC: IDA); GO_1901296 (EC: IDA); GO_2000726 (EC: IDA)
has PubMed association: PMID: 10383463; 10570958; 10965128; 11357136; 11448771; 11516963; 11742004; 11840333; 12050670; 12167704; 12477932; 12740383; 12975309; 14695408; 15035989; 15117970; 15229249; 15231748; 15340161; 15378020; 15451431; 15489334; 15542433; 15592430; 15592505; 15694380; 15923613; 16189514; 16263759; 16293576; 16491118; 16568085; 16646053; 16763196; 16863544; 16919965; 17026960; 17068150; 17159916; 17237793; 17245340; 17255354; 17329407; 17353931; 17373700; 17449905; 17485441; 17643814; 17657240; 17700537; 17702698; 17804805; 17876334; 17984176; 17987039; 18044981; 18157634; 18163421; 18166153; 18294945; 18297060; 18305214; 18331598; 18339843; 18461655; 18502762; 18505732; 18521528; 18546262; 18561248; 18571836; 18606139; 18653765; 18843784; 18978943; 19016584; 19040566; 19060904; 19067746; 19093005; 19247449; 19252761; 19273195; 19303159; 19358268; 19389391; 19396460; 19407319; 19424619; 19453261; 19477926; 19540374; 19657367; 19675559; 19711349; 19720407; 19744316; 19746449; 19776352; 19787627; 19820386; 19832854; 19895917; 19898734; 19926868; 19936252; 19943155; 19955106; 19995224; 20004015; 20019092; 20033851; 20038269; 20039407; 20062063; 20093360; 20101398; 20139903; 20153141; 20543981; 20549706; 20589421; 20603237; 20613589; 20618428; 20628624; 20634891; 20650998; 20653953; 20797317; 20819596; 20823417; 20843343; 20847303; 20920327; 20929859; 20932948; 20957670; 21029453; 21034532; 21062498; 21076409; 21098705; 21164019; 21304055; 21317455; 21344486; 21362762; 21389688; 21531794; 21540552; 21546446; 21562161; 21607803; 21617850; 21663914; 21683813; 21712726; 21805521; 21811562; 21833531; 21858178; 21909757; 21935273; 21944272; 21944579; 21955977; 21984209; 21988832; 22000856; 22015605; 22022386; 22032557; 22042700; 22048647; 22120987; 22122879; 22278426; 22321022; 22358062; 22363428; 22386696; 22391424; 22399772; 22430125; 22447857; 22455953; 22496615; 22527202; 22576962; 22589387; 22592030; 22649545; 22723594; 22738799; 22789636; 22796372; 22815877; 22898215; 2296…
description: dickkopf WNT signaling pathway inhibitor 1
database cross reference: Ensembl:ENSG00000107984
database cross reference: HGNC:2891
database cross reference: HPRD:05544
database cross reference: MIM:605189
database cross reference: Vega:OTTHUMG00000018247

UNC13A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: Munc13-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: UNC13A
full name from nomenclature authority: unc-13 homolog A (C. elegans)
NCBI GeneID: 23025
gene map location: 19p13.11
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001956 (EC: IEA); GO_0005737 (EC: IEA); GO_0007528 (EC: IEA); GO_0016081 (EC: IEA); GO_0016188 (EC: IEA); GO_0019992 (EC: IEA); GO_0030054 (EC: IEA); GO_0031594 (EC: IEA); GO_0035249 (EC: IEA); GO_0035556 (EC: IEA); GO_0042734 (EC: IEA); GO_0046872 (EC: IEA); GO_0048172 (EC: IEA); GO_0050435 (EC: IEA); GO_0060384 (EC: IEA)
has PubMed association: PMID: 10470851; 12421765; 12477932; 12871971; 14702039; 14734538; 15123597; 16344560; 19734901; 19996097; 20379614; 20385924; 22118904; 22248876; 22921269; 22959728; 23251661; 23801330; 24250222
description: unc-13 homolog A (C. elegans)
database cross reference: Ensembl:ENSG00000130477
database cross reference: HGNC:23150
database cross reference: MIM:609894
database cross reference: Vega:OTTHUMG00000163877

WWC1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HBEBP3
alternative term: HBEBP36
alternative term: KIBRA
alternative term: MEMRYQTL
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: WWC1
full name from nomenclature authority: WW and C2 domain containing 1
NCBI GeneID: 23286
gene map location: 5q34
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003713 (EC: IDA, PMID: 16684779); GO_0005515 (EC: IPI, PMID: 16684779); GO_0005634 (EC: IDA, PMID: 16684779); GO_0005737 (EC: IDA, PMID: 16684779); GO_0005829 (EC: TAS); GO_0006351 (EC: IEA); GO_0006355 (EC: IEA); GO_0016477 (EC: IDA, PMID: 18596123); GO_0030674 (EC: IEA); GO_0032587 (EC: IDA, PMID: 18190796); GO_0035329 (EC: TAS); GO_0035330 (EC: IMP); GO_0043234 (EC: IEA); GO_0043410 (EC: IDA, PMID: 18190796); GO_0048471 (EC: IDA, PMID: 18596123)
has PubMed association: PMID: 8889548; 10048485; 12477932; 12559952; 14702039; 15081397; 15489334; 16169070; 16484223; 16684779; 17010949; 17043677; 17053149; 17353070; 17707552; 17994011; 18029348; 18190796; 18194457; 18205171; 18378080; 18596123; 18672031; 18789830; 19058786; 19397951; 19606085; 19804789; 20125193; 20150879; 20185150; 20379614; 20509760; 20691427; 20881395; 21173572; 21185624; 21204039; 21233212; 21346737; 21497093; 21643791; 21878642; 21900206; 21943600; 21976506; 22129841; 22430796; 22614006; 22699663; 22784093; 22794909; 22904328; 22948661; 23065961; 23163744; 23266749; 23778582; 23926262; 24255178
description: WW and C2 domain containing 1
database cross reference: Ensembl:ENSG00000113645
database cross reference: HGNC:29435
database cross reference: HPRD:10033
database cross reference: MIM:610533
database cross reference: Vega:OTTHUMG00000130408

NCSTN
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ATAG1874
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NCSTN
full name from nomenclature authority: nicastrin
NCBI GeneID: 23385
NCBI LocusTag: RP11-517F10.1
gene map location: 1q22-q23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002262 (EC: IEA); GO_0004175 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12297508); GO_0005765 (EC: IDA, PMID: 17897319); GO_0005783 (EC: IDA, PMID: 15274632); GO_0005783 (EC: ISS); GO_0005794 (EC: IDA, PMID: 15274632); GO_0005794 (EC: ISS); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 15274632); GO_0005887 (EC: ISS); GO_0006508 (EC: NAS, PMID: 10993067); GO_0006509 (EC: IDA, PMID: 15274632); GO_0006509 (EC: ISS); GO_0007219 (EC: TAS); GO_0007220 (EC: TAS, PMID: 15274632); GO_0016021 (EC: NAS, PMID: 10993067); GO_0016485 (EC: IDA, PMID: 15274632); GO_0016485 (EC: ISS); GO_0022617 (EC: TAS); GO_0030198 (EC: TAS); GO_0031293 (EC: TAS); GO_0042098 (EC: IEA); GO_0042470 (EC: IEA); GO_0042987 (EC: TAS, PMID: 15274632); GO_0043065 (EC: TAS); GO_0043085 (EC: IDA, PMID: 15274632); GO_0043085 (EC: ISS); GO_0048011 (EC: TAS); GO_0050435 (EC: IEA); GO_0050673 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867); GO_0097190 (EC: TAS)
has PubMed association: PMID: 9039502; 10993067; 11295540; 11396676; 11483961; 11726200; 11943765; 11992262; 12021275; 12032140; 12044882; 12048259; 12054507; 12130643; 12198112; 12297508; 12419494; 12471034; 12477932; 12603837; 12643545; 12644462; 12660785; 12679784; 12692078; 12736250; 12740439; 12754519; 12763021; 12787561; 12815056; 12821663; 12843241; 12857757; 12917438; 14572442; 14593096; 14602727; 14642438; 14664923; 15146197; 15157994; 15189355; 15210705; 15249634; 15257293; 15274632; 15322084; 15322109; 15474363; 15489334; 15567563; 15591316; 15711015; 15721744; 15975090; 16303145; 16423463; 16630834; 16641999; 16938437; 17081065; 17192785; 17897319; 17986144; 18201567; 18667537; 19028695; 19056867; 19077115; 19105203; 19187441; 19322201; 19394408; 19684016; 19729449; 19840113; 20224929; 20880607; 20929727; 21123562; 21364883; 21412258; 21430701; 21495993; 21674799; 21725355; 21848507; 21906983; 21963094; 21987572; 22086926; 22268729; 22358060; 22404891; 22405046; 22586122; 22590650; 22622421; 22779921; 22787765; 22834455; 22939629; 23012411; 23096707; 23517242; 23585889; 23595812
description: nicastrin
database cross reference: Ensembl:ENSG00000162736
database cross reference: HGNC:17091
database cross reference: HPRD:05584
database cross reference: MIM:605254
database cross reference: Vega:OTTHUMG00000033110

SIRT5
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SIR2L5
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SIRT5
full name from nomenclature authority: sirtuin 5
NCBI GeneID: 23408
gene map location: 6p23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003950 (EC: TAS, Qualifier: NOT, PMID: 17456799); GO_0005634 (EC: TAS); GO_0005739 (EC: IDA); GO_0005758 (EC: IDA, PMID: 18680753); GO_0005759 (EC: IDA, PMID: 18680753); GO_0005829 (EC: IDA); GO_0006342 (EC: TAS, PMID: 10381378); GO_0006471 (EC: TAS, Qualifier: NOT, PMID: 17456799); GO_0006476 (EC: IDA, PMID: 18680753); GO_0006476 (EC: IDA, Qualifier: NOT); GO_0008270 (EC: IDA); GO_0036047 (EC: IDA); GO_0036048 (EC: IDA); GO_0036049 (EC: IDA); GO_0036054 (EC: IDA); GO_0036055 (EC: IDA); GO_0070403 (EC: IDA); GO_2000378 (EC: IDA)
has PubMed association: PMID: 10381378; 10873683; 11076863; 11256614; 12477932; 14574404; 14702039; 15489334; 15489336; 16079181; 16381901; 16484774; 16712791; 16827919; 17456799; 17715127; 18029348; 18680753; 19135889; 20800603; 20877624; 20887790; 21139048; 21143562; 21832049; 21908771; 22076378; 22585829; 22767592; 23028781; 23475622; 24140062; 24163370; 24250222
description: sirtuin 5
database cross reference: Ensembl:ENSG00000124523
database cross reference: HGNC:14933
database cross reference: HPRD:06838
database cross reference: MIM:604483
database cross reference: Vega:OTTHUMG00000014278

SIRT4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SIR2L4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SIRT4
full name from nomenclature authority: sirtuin 4
NCBI GeneID: 23409
gene map location: 12q
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003950 (EC: IDA, PMID: 16959573); GO_0003950 (EC: TAS, PMID: 17456799); GO_0005515 (EC: IPI, PMID: 16959573); GO_0005739 (EC: IDA, PMID: 16079181); GO_0005759 (EC: IDA, PMID: 16959573); GO_0006342 (EC: TAS, PMID: 10381378); GO_0006471 (EC: ISS); GO_0006471 (EC: TAS, PMID: 17456799); GO_0006541 (EC: ISS); GO_0006974 (EC: ISS); GO_0034979 (EC: IDA, Qualifier: NOT, PMID: 17715127); GO_0034983 (EC: ISS); GO_0046322 (EC: ISS); GO_0046676 (EC: IMP, PMID: 17715127); GO_0046872 (EC: IEA); GO_0046889 (EC: ISS); GO_0070403 (EC: IEA); GO_0072350 (EC: ISS)
has PubMed association: PMID: 9847074; 10381378; 10873683; 12477932; 15122253; 15342556; 15489334; 16079181; 16541075; 16959573; 17456799; 17715127; 19209188; 21556116; 22770219; 23044393; 23045395; 23663782; 24250222
description: sirtuin 4
database cross reference: Ensembl:ENSG00000089163
database cross reference: HGNC:14932
database cross reference: HPRD:06837
database cross reference: MIM:604482
database cross reference: Vega:OTTHUMG00000169028

SIRT3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SIR2L3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SIRT3
full name from nomenclature authority: sirtuin 3
NCBI GeneID: 23410
gene map location: 11p15.5
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003950 (EC: TAS, Qualifier: NOT, PMID: 17456799); GO_0005515 (EC: IPI, PMID: 16788062); GO_0005739 (EC: IDA, PMID: 16079181); GO_0005759 (EC: IEA); GO_0006471 (EC: TAS, Qualifier: NOT, PMID: 17456799); GO_0006476 (EC: IDA, PMID: 16788062); GO_0008270 (EC: IDA, PMID: 19535340); GO_0009060 (EC: IMP); GO_0016020 (EC: IEA); GO_0032041 (EC: IEA); GO_0034983 (EC: IMP); GO_0070403 (EC: IEA)
has PubMed association: PMID: 8889548; 10381378; 10873683; 11056054; 12186850; 12374852; 12477932; 15489334; 15676284; 15719057; 16079181; 16169070; 16189514; 16788062; 17059877; 17437997; 17456799; 17715127; 17957139; 18215119; 18680753; 18710944; 18781224; 19209188; 19240061; 19343720; 19367319; 19535340; 19680556; 19714312; 20129246; 20132432; 20159966; 20198340; 20463968; 20661474; 20800603; 20819778; 20877624; 20945913; 21358671; 21397863; 21449565; 21460842; 21566644; 21701047; 21840382; 22155639; 22326535; 22416140; 22585829; 22589271; 22595756; 22609775; 22674009; 22750084; 22770219; 23045395; 23046812; 23075334; 23139766; 23272146; 23397292; 23665396; 23790338; 23800187; 23856293; 23868064; 23898059; 23956348; 24026423; 24121500; 24194516; 24324009
description: sirtuin 3
database cross reference: Ensembl:ENSG00000142082
database cross reference: HGNC:14931
database cross reference: HPRD:06836
database cross reference: MIM:604481
database cross reference: Vega:OTTHUMG00000119074

SIRT1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SIR2L1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SIRT1
full name from nomenclature authority: sirtuin 1
NCBI GeneID: 23411
NCBI LocusTag: RP11-57G10.3
gene map location: 10q21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000012 (EC: IMP); GO_0000122 (EC: IDA, PMID: 12535671); GO_0000122 (EC: IMP); GO_0000183 (EC: IDA, PMID: 18485871); GO_0000720 (EC: IMP); GO_0000731 (EC: ISS); GO_0000790 (EC: IDA, PMID: 17505061); GO_0001525 (EC: IDA); GO_0001542 (EC: IEA); GO_0001678 (EC: ISS); GO_0001934 (EC: ISS); GO_0002039 (EC: IPI, PMID: 11672523); GO_0002821 (EC: IDA); GO_0003714 (EC: IDA, PMID: 12535671); GO_0003714 (EC: ISS); GO_0003950 (EC: TAS, Qualifier: NOT, PMID: 17456799); GO_0004407 (EC: IDA); GO_0005515 (EC: IPI, PMID: 11672523); GO_0005634 (EC: IDA); GO_0005635 (EC: IDA, PMID: 15469825); GO_0005637 (EC: IDA, PMID: 15469825); GO_0005654 (EC: IDA, PMID: 16079181); GO_0005677 (EC: IDA, PMID: 18485871); GO_0005719 (EC: IDA, PMID: 15469825); GO_0005720 (EC: IDA, PMID: 15469825); GO_0005730 (EC: IDA, PMID: 15469825); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005737 (EC: IDA, Qualifier: NOT, PMID: 15469825); GO_0005739 (EC: IDA); GO_0006260 (EC: TAS, PMID: 17317627); GO_0006281 (EC: TAS, PMID: 17317627); GO_0006342 (EC: TAS, PMID: 10381378); GO_0006343 (EC: IDA, PMID: 15469825); GO_0006344 (EC: IMP, PMID: 15469825); GO_0006346 (EC: TAS); GO_0006351 (EC: IEA); GO_0006364 (EC: IEA); GO_0006471 (EC: TAS, Qualifier: NOT, PMID: 17456799); GO_0006476 (EC: IDA, PMID: 18203716); GO_0006476 (EC: IMP, PMID: 11672523); GO_0006642 (EC: ISS); GO_0006974 (EC: IDA, PMID: 18203716); GO_0006979 (EC: IDA, PMID: 14976264); GO_0007283 (EC: IEA); GO_0007346 (EC: IDA, PMID: 15692560); GO_0007517 (EC: IEA); GO_0007569 (EC: TAS, PMID: 11672523); GO_0008022 (EC: IPI, PMID: 18203716); GO_0008284 (EC: IMP); GO_0009267 (EC: ISS); GO_0010875 (EC: ISS); GO_0010906 (EC: ISS); GO_0016032 (EC: IEA); GO_0016239 (EC: IDA, PMID: 18296641); GO_0016567 (EC: IDA); GO_0016575 (EC: IDA, PMID: 12006491); GO_0016605 (EC: IDA, PMID: 12006491); GO_0017136 (EC: IDA, PMID: 12006491); GO_0018394 (EC: IMP, PMID: 18004385); GO_0019213 (EC: IDA, PMID: 18203716); GO_0030308 (EC: IMP, PMID: 17505061); GO_0030512 (…
has PubMed association: PMID: 10381378; 10873683; 11230166; 11672522; 11672523; 12006491; 12297502; 12413881; 12477932; 12535671; 12930829; 12939617; 14702039; 14976264; 14980222; 15126506; 15152190; 15164054; 15175761; 15205477; 15302935; 15469825; 15489334; 15632193; 15639232; 15640142; 15684044; 15692560; 15719057; 15744310; 15749705; 15780941; 16079181; 16154098; 16166628; 16183991; 16207712; 16257164; 16269335; 16288004; 16328012; 16344560; 16354677; 16385451; 16628003; 16751189; 16892051; 16923962; 16959573; 16964243; 16998474; 16998810; 17041012; 17081983; 17098745; 17099246; 17112576; 17172643; 17180656; 17213307; 17283066; 17317627; 17334224; 17373700; 17456799; 17487425; 17505061; 17516504; 17581637; 17601350; 17612497; 17624472; 17638871; 17680780; 17785417; 17806102; 17895433; 17901049; 17916362; 17934453; 17936707; 17937892; 17964266; 17996922; 18004385; 18029348; 18174544; 18184747; 18193082; 18203716; 18230337; 18235501; 18235502; 18296641; 18329615; 18342601; 18344999; 18414679; 18438697; 18482975; 18485871; 18485895; 18556572; 18563176; 18573234; 18636124; 18660489; 18662546; 18662547; 18681908; 18687677; 18689793; 18704159; 18723829; 18724249; 18755897; 18774777; 18800364; 18820948; 18821472; 18823944; 18829436; 18829956; 18834855; 18835033; 18838864; 18850005; 18922603; 18957417; 18977241; 19008647; 19014491; 19017485; 19047049; 19060927; 19071085; 19075016; 19104446; 19132007; 19149601; 19166820; 19167483; 19188449; 19218236; 19220062; 19229036; 19236849; 19244234; 19267881; 19285077; 19286634; 19289152; 19322201; 19343720; 19364925; 19376817; 19377286; 19404850; 19430421; 19433578; 19478080; 19491102; 19498162; 19509139; 19553684; 19555662; 19568959; 19578370; 19581416; 19615732; 19643082; 19649206; 19664641; 19680556; 19690166; 19713122; 19714620; 19716821; 19720090; 19741164; 19786632; 19819989; 19883617; 19887452; 19895790; 19923004; 19934257; 19934264; 19995796; 19996091; 20027304; 20033348; 20041875; 20042607; 20060806; 20068143; 20071779; 20089851; 20100829; 2010…
description: sirtuin 1
database cross reference: Ensembl:ENSG00000096717
database cross reference: HGNC:14929
database cross reference: HPRD:08381
database cross reference: MIM:604479
database cross reference: Vega:OTTHUMG00000018340

NOMO1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: Nomo
alternative term: PM5
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NOMO1
full name from nomenclature authority: NODAL modulator 1
NCBI GeneID: 23420
gene map location: 16p13.11
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003674 (EC: ND); GO_0005575 (EC: ND); GO_0008150 (EC: ND); GO_0016021 (EC: IEA); GO_0030246 (EC: IEA)
has PubMed association: PMID: 1310294; 8076819; 9267806; 10493829; 12477932; 15231747; 15231748; 15257293; 15616553; 15862967; 16169070; 16713569; 21319273; 21890473; 21906983; 21963094; 21987572; 21988832; 22268729; 22505724; 22832245; 22939629; 22990118; 23000965; 24250222
description: NODAL modulator 1
database cross reference: Ensembl:ENSG00000103512
database cross reference: HGNC:30060
database cross reference: HPRD:11398
database cross reference: MIM:609157
database cross reference: Vega:OTTHUMG00000090541

TARDBP
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ALS10
alternative term: TDP-43
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TARDBP
full name from nomenclature authority: TAR DNA binding protein
NCBI GeneID: 23435
NCBI LocusTag: RP4-635E18.2
gene map location: 1p36.22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000166 (EC: IEA); GO_0003690 (EC: IDA, PMID: 7745706); GO_0003700 (EC: TAS, PMID: 7745706); GO_0003723 (EC: IDA, PMID: 11285240); GO_0003730 (EC: IDA, PMID: 17481916); GO_0005515 (EC: IPI); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0006366 (EC: TAS, PMID: 7745706); GO_0006397 (EC: IEA); GO_0008219 (EC: IEA); GO_0008380 (EC: IDA, PMID: 11285240); GO_0042802 (EC: IPI); GO_0043922 (EC: IDA, PMID: 7745706); GO_0044822 (EC: IDA); GO_0070935 (EC: IDA, PMID: 17481916)
has PubMed association: PMID: 7745706; 8125298; 8599929; 8889548; 11076863; 11230166; 11256614; 11285240; 11470789; 12361981; 12477932; 15231747; 15489334; 15489336; 16157593; 16169070; 16381901; 16710414; 17023659; 17081983; 17360763; 17481916; 17492294; 17569066; 17614162; 17623298; 17643375; 17653732; 17981595; 18029348; 18068872; 18087705; 18088371; 18206910; 18288693; 18304732; 18305110; 18305152; 18309045; 18372902; 18377426; 18379440; 18391021; 18396105; 18438952; 18505686; 18506455; 18520774; 18545701; 18546284; 18549326; 18584184; 18592312; 18634762; 18656473; 18657254; 18703504; 18723384; 18723524; 18755042; 18779421; 18802454; 18843496; 18923836; 18929508; 18931000; 18957508; 18974920; 18989684; 19018245; 19039597; 19048944; 19066918; 19111550; 19112176; 19125255; 19139310; 19139911; 19164285; 19191304; 19204154; 19204172; 19217189; 19224587; 19225410; 19228676; 19235466; 19236453; 19237541; 19283396; 19285963; 19303844; 19306141; 19330339; 19338576; 19350673; 19383787; 19411082; 19422539; 19455346; 19465477; 19471022; 19515851; 19526244; 19533646; 19560462; 19609911; 19618195; 19664364; 19685386; 19695877; 19714537; 19738201; 19760257; 19781077; 19786775; 19798749; 19808791; 19815002; 19816201; 19833869; 19851068; 19864663; 19864664; 19887443; 19910924; 19938687; 19944744; 19959528; 20008652; 20020773; 20031275; 20043239; 20047951; 20055380; 20071528; 20082726; 20133711; 20154090; 20154440; 20175762; 20225928; 20236174; 20301623; 20301761; 20360068; 20372915; 20423455; 20447446; 20472325; 20519548; 20530643; 20551689; 20554523; 20555136; 20558162; 20558945; 20577002; 20600671; 20621187; 20624952; 20645878; 20669025; 20675015; 20697052; 20702714; 20708823; 20720006; 20720505; 20736350; 20804554; 20864052; 20933032; 20937952; 20948999; 20951205; 20959352; 21062285; 21086759; 21118398; 21120508; 21123567; 21126161; 21131904; 21139048; 21145461; 21172843; 21172844; 21206091; 21209826; 21220647; 21243369; 21252943; 21257637; 21339291; 21355045; 21358640; 21376022; 21403029; 21412434…
description: TAR DNA binding protein
database cross reference: HGNC:11571
database cross reference: HPRD:05466
database cross reference: MIM:605078

CD2AP
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CMS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CD2AP
full name from nomenclature authority: CD2-associated protein
NCBI GeneID: 23607
gene map location: 6p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001726 (EC: IDA, PMID: 10339567); GO_0005172 (EC: IEA); GO_0005200 (EC: TAS, PMID: 10339567); GO_0005515 (EC: IPI, PMID: 10339567); GO_0005737 (EC: TAS, PMID: 10339567); GO_0005886 (EC: IEA); GO_0006461 (EC: TAS, PMID: 10339567); GO_0006930 (EC: TAS, PMID: 10339567); GO_0007067 (EC: IEA); GO_0007165 (EC: NAS, PMID: 10339567); GO_0008013 (EC: IEA); GO_0008022 (EC: IEA); GO_0015629 (EC: TAS, PMID: 10339567); GO_0016050 (EC: IEA); GO_0016337 (EC: IEA); GO_0017124 (EC: IPI, PMID: 10339567); GO_0030139 (EC: IEA); GO_0031941 (EC: IDA, PMID: 10339567); GO_0032403 (EC: IEA); GO_0043161 (EC: IEA); GO_0045296 (EC: IEA); GO_0048259 (EC: IEA); GO_0048471 (EC: IEA); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 8889548; 9741631; 10339567; 10913159; 10997929; 11067845; 11733557; 12029088; 12477932; 12530983; 12559036; 12618476; 12672817; 12690097; 12764198; 14679214; 14736876; 15128873; 15489334; 15592455; 15659563; 15800069; 16344560; 16678097; 16707503; 16895919; 17020880; 17072306; 17081983; 17188587; 17283187; 17428861; 17474147; 17606992; 17713465; 17823309; 17853893; 17922258; 18029348; 18396147; 18654987; 18753381; 18791326; 19056867; 19131354; 19380743; 19738201; 19945749; 19956976; 20360068; 20379614; 20404345; 20457601; 20515931; 20654576; 20697350; 21460840; 21460841; 21519904; 21655212; 21706016; 21822214; 21890473; 21911934; 21963094; 21988832; 22412018; 22623428; 22706086; 22745667; 22863883; 22880102; 22939629; 23279575; 24039852; 24167568; 24322428
description: CD2-associated protein
database cross reference: Ensembl:ENSG00000198087
database cross reference: HGNC:14258
database cross reference: HPRD:05026
database cross reference: MIM:604241
database cross reference: Vega:OTTHUMG00000014799

BACE1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ASP2
alternative term: BACE
alternative term: HSPC104
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: BACE1
full name from nomenclature authority: beta-site APP-cleaving enzyme 1
NCBI GeneID: 23621
gene map location: 11q23.2-q23.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004190 (EC: IDA, PMID: 10531052); GO_0005768 (EC: IDA, PMID: 10531052); GO_0005783 (EC: IEA); GO_0005794 (EC: IDA, PMID: 10531052); GO_0005802 (EC: IDA, PMID: 11466313); GO_0005887 (EC: IDA, PMID: 12586838); GO_0006508 (EC: IDA, PMID: 10531052); GO_0006509 (EC: TAS, PMID: 12354787); GO_0008798 (EC: TAS, PMID: 10591214); GO_0009986 (EC: IEA); GO_0016021 (EC: NAS, PMID: 10531052); GO_0019899 (EC: IPI, PMID: 12586838); GO_0030424 (EC: IEA); GO_0030659 (EC: IEA); GO_0050435 (EC: IDA, PMID: 15080893)
has PubMed association: PMID: 10531052; 10574461; 10591213; 10591214; 10656250; 10677483; 10749877; 10801872; 10887202; 10956649; 11021803; 11032903; 11152683; 11234778; 11266439; 11278841; 11466313; 11516562; 11684351; 11714100; 11741910; 11744168; 11847218; 11860271; 11922623; 11953458; 12054507; 12054559; 12093293; 12112088; 12135764; 12206667; 12223024; 12270690; 12354787; 12438920; 12445809; 12471021; 12477932; 12514700; 12535780; 12586836; 12586838; 12618121; 12649271; 12665519; 12707937; 12801932; 12824768; 12857759; 12901838; 12928915; 14507929; 14567678; 14681914; 14699153; 14701757; 14748006; 14748707; 14978286; 14991462; 15034149; 15059975; 15059977; 15080893; 15096037; 15117318; 15197182; 15211591; 15213451; 15234966; 15247262; 15286784; 15451669; 15452128; 15466887; 15485862; 15489334; 15491607; 15584902; 15592644; 15606899; 15615712; 15628850; 15671026; 15749709; 15784960; 15824102; 15857888; 15880353; 15886016; 15931081; 16027115; 16033761; 16181410; 16243299; 16246054; 16249081; 16279945; 16303743; 16342950; 16354928; 16449801; 16605258; 16611980; 16679558; 16716081; 16757811; 16769154; 16816111; 16897184; 16908986; 16965550; 16979658; 17113083; 17174011; 17236572; 17293612; 17307738; 17331621; 17409228; 17425515; 17511654; 17576410; 17596706; 17601350; 17699523; 17854420; 17897958; 17961921; 18039469; 18163181; 18177262; 18182389; 18182766; 18255190; 18263584; 18307033; 18374657; 18378702; 18393796; 18434550; 18581272; 18587408; 18632981; 18650447; 18660751; 18695061; 18790604; 18798280; 18805488; 18977241; 19011241; 19056495; 19057901; 19074428; 19106624; 19153172; 19196715; 19251705; 19302194; 19344981; 19372755; 19405102; 19429494; 19462468; 19508864; 19682432; 19815556; 19827607; 19889475; 19968762; 20041192; 20066010; 20080541; 20089133; 20127045; 20164582; 20212127; 20236612; 20354142; 20455082; 20468060; 20484053; 20607864; 20685197; 20726888; 20806954; 20849576; 20853423; 20854419; 20930275; 20930286; 20946940; 21209097; 21245145; 21321391; 21354237; 21440067; 2150…
description: beta-site APP-cleaving enzyme 1
database cross reference: Ensembl:ENSG00000186318
database cross reference: HGNC:933
database cross reference: HPRD:07255
database cross reference: MIM:604252
database cross reference: Vega:OTTHUMG00000160636

NUP62
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: IBSN
alternative term: SNDI
alternative term: p62
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NUP62
full name from nomenclature authority: nucleoporin 62kDa
NCBI GeneID: 23636
gene map location: 19q13.33
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000278 (EC: TAS); GO_0000922 (EC: IEA); GO_0003682 (EC: NAS, PMID: 11852044); GO_0005487 (EC: NAS, Qualifier: contributes_to, PMID: 8589458); GO_0005515 (EC: IPI, PMID: 10356400); GO_0005635 (EC: IDA); GO_0005635 (EC: TAS); GO_0005643 (EC: IDA, PMID: 1915414); GO_0005643 (EC: ISS); GO_0005737 (EC: NAS, PMID: 10373430); GO_0005975 (EC: TAS); GO_0006351 (EC: IDA, PMID: 10373430); GO_0006351 (EC: ISS); GO_0006913 (EC: NAS, PMID: 8589458); GO_0007077 (EC: TAS); GO_0007166 (EC: IDA, PMID: 10799545); GO_0007166 (EC: ISS); GO_0007166 (EC: NAS, PMID: 10373430); GO_0007569 (EC: IEA); GO_0008219 (EC: IMP, PMID: 11244088); GO_0008219 (EC: ISS); GO_0008285 (EC: IDA, PMID: 11013214); GO_0008285 (EC: ISS); GO_0008645 (EC: TAS); GO_0009755 (EC: NAS, PMID: 15625236); GO_0009966 (EC: NAS, PMID: 8702753); GO_0010827 (EC: TAS); GO_0015031 (EC: IEA); GO_0015758 (EC: TAS); GO_0016032 (EC: TAS); GO_0017056 (EC: IEA); GO_0019221 (EC: TAS); GO_0030159 (EC: IDA, PMID: 11244088); GO_0030159 (EC: ISS); GO_0030529 (EC: IDA, PMID: 18809582); GO_0031074 (EC: NAS, PMID: 8589458); GO_0031965 (EC: IDA); GO_0042059 (EC: IEA); GO_0042169 (EC: IDA, PMID: 8650207); GO_0042169 (EC: ISS); GO_0043066 (EC: IDA, PMID: 11755531); GO_0043066 (EC: ISS); GO_0043069 (EC: IDA, PMID: 11244088); GO_0043069 (EC: ISS); GO_0043123 (EC: IDA, PMID: 10356400); GO_0043123 (EC: ISS); GO_0043130 (EC: IDA, PMID: 8702753); GO_0043130 (EC: ISS); GO_0043231 (EC: IDA); GO_0043407 (EC: IEA); GO_0044281 (EC: TAS); GO_0045742 (EC: NAS, PMID: 11244088); GO_0045893 (EC: IDA, PMID: 15625236); GO_0045893 (EC: ISS); GO_0046578 (EC: NAS, PMID: 11553620); GO_0046580 (EC: IEA); GO_0046930 (EC: NAS, PMID: 15175862); GO_0046966 (EC: IPI, PMID: 15625236); GO_0046966 (EC: ISS); GO_0051028 (EC: IEA); GO_0051425 (EC: IEA); GO_0055085 (EC: TAS)
has PubMed association: PMID: 1915414; 7744965; 8125298; 8537436; 8589458; 8650207; 8702753; 8707840; 8757804; 8889548; 9102465; 9114010; 9348540; 9367915; 9407313; 10330396; 10356400; 10373430; 10395558; 10601273; 10668806; 10781837; 10799545; 11013214; 11073998; 11076863; 11113176; 11230166; 11238447; 11244088; 11256614; 11266456; 11310559; 11425870; 11553620; 11755531; 11852044; 12163599; 12228227; 12477932; 12894213; 14667819; 14702039; 14718703; 15175862; 15489334; 15489336; 15507209; 15522285; 15625236; 15820316; 15953362; 16169070; 16189514; 16314397; 16344560; 16381901; 16434389; 16648475; 16730000; 16786527; 17098863; 17500061; 17960595; 18029348; 18292223; 18809582; 18854154; 19144712; 19615732; 19828735; 20360068; 20622012; 21078624; 21139048; 21145461; 21698267; 21726808; 21890473; 21906983; 21988832; 22110128; 22308026; 22334672; 22505724; 22558357; 22928108; 22939629; 23383273; 23777819; 24074597; 24250222
description: nucleoporin 62kDa
database cross reference: Ensembl:ENSG00000213024
database cross reference: HGNC:8066
database cross reference: HPRD:05782
database cross reference: MIM:605815
database cross reference: Vega:OTTHUMG00000183077

FKBP8
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FKBP38
alternative term: FKBPr38
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: FKBP8
full name from nomenclature authority: FK506 binding protein 8, 38kDa
NCBI GeneID: 23770
gene map location: 19p12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000413 (EC: IBA); GO_0003755 (EC: IBA); GO_0005515 (EC: IPI, PMID: 16844119); GO_0005528 (EC: IBA); GO_0005740 (EC: IBA); GO_0006457 (EC: IEA); GO_0006915 (EC: IEA); GO_0016032 (EC: IEA); GO_0018208 (EC: IBA); GO_0030176 (EC: IBA); GO_0031966 (EC: IEA); GO_0035556 (EC: TAS, PMID: 10197430); GO_0042802 (EC: IPI, PMID: 17024179); GO_0046872 (EC: IEA)
has PubMed association: PMID: 7543869; 8889548; 10197430; 11076863; 11230166; 12477932; 12510191; 12894220; 15057824; 15105374; 15489334; 15489336; 15592455; 15733859; 15757646; 15990872; 16169070; 16176796; 16341674; 16381901; 16604427; 16844119; 17024179; 17082457; 17090549; 17353276; 17379601; 17569659; 17573772; 17942410; 17986458; 17991864; 18216108; 18385096; 18459960; 18658153; 18676370; 19147576; 19222999; 19546213; 19615732; 20029029; 20048149; 20139069; 20140889; 20707607; 20877624; 21044950; 21139048; 21145461; 21320469; 21360678; 21559462; 21737445; 21890473; 21906983; 21988832; 22030396; 22474283; 22523079; 22645275; 22797925; 22810585; 22939629; 23000965; 23455922; 23464991; 23602568; 23798571
description: FK506 binding protein 8, 38kDa
database cross reference: Ensembl:ENSG00000105701
database cross reference: HGNC:3724
database cross reference: HPRD:05327
database cross reference: MIM:604840
database cross reference: Vega:OTTHUMG00000183368

CNTNAP2
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AUTS15
alternative term: CASPR2
alternative term: CDFE
alternative term: NRXN4
alternative term: PTHSL1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CNTNAP2
full name from nomenclature authority: contactin associated protein-like 2
NCBI GeneID: 26047
gene map location: 7q35
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005769 (EC: IDA, PMID: 19706678); GO_0005794 (EC: IDA, PMID: 19166515); GO_0007155 (EC: IEA); GO_0007420 (EC: TAS, PMID: 10624965); GO_0007612 (EC: IMP, PMID: 18179893); GO_0008038 (EC: NAS, PMID: 10624965); GO_0008076 (EC: IDA, PMID: 10624965); GO_0009986 (EC: IDA, PMID: 19706678); GO_0016020 (EC: IDA, PMID: 10624965); GO_0016021 (EC: NAS, PMID: 11352571); GO_0019226 (EC: NAS, PMID: 11352571); GO_0019899 (EC: IPI, PMID: 19166515); GO_0021756 (EC: IEP, PMID: 18179893); GO_0021761 (EC: IEP, PMID: 18179895); GO_0021794 (EC: IEP, PMID: 18179893); GO_0021987 (EC: IEP, PMID: 18179893); GO_0030424 (EC: ISS); GO_0030425 (EC: ISS); GO_0030534 (EC: IMP, PMID: 18179893); GO_0030673 (EC: IDA, PMID: 19706678); GO_0031175 (EC: ISS); GO_0034613 (EC: ISS); GO_0035176 (EC: IMP, PMID: 18179893); GO_0043025 (EC: ISS); GO_0043204 (EC: ISS); GO_0044224 (EC: ISS); GO_0045163 (EC: ISS); GO_0071109 (EC: IEP, PMID: 18179893); GO_0071205 (EC: ISS); GO_0071625 (EC: IMP, PMID: 18179893)
has PubMed association: PMID: 10048485; 10624965; 11352571; 12093160; 12421765; 12477932; 12542678; 12690205; 12809671; 12853948; 12963709; 12975355; 14702039; 15203218; 15489334; 16571880; 17392702; 17646849; 17903296; 18179893; 18179894; 18179895; 18496130; 18512134; 18957941; 18987363; 19086053; 19166515; 19546859; 19582487; 19706678; 19889080; 19896112; 19913121; 20157312; 20176116; 20200978; 20379614; 20414140; 20421335; 20446882; 20502679; 20628086; 20711234; 20808326; 20889312; 21048216; 21193173; 21310003; 21387375; 21448237; 21565611; 21827697; 21906983; 21987501; 22031302; 22159054; 22365836; 22429864; 22500773; 22589738; 22690117; 22728895; 22744455; 22872700; 22948383; 23074245; 23115634; 23123147; 23192594; 23251661; 23277129; 23382691; 23407760; 23459443; 23871450
description: contactin associated protein-like 2
database cross reference: Ensembl:ENSG00000174469
database cross reference: HGNC:13830
database cross reference: HPRD:05197
database cross reference: MIM:604569
database cross reference: Vega:OTTHUMG00000152743

GAPDHS
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GAPD2
alternative term: GAPDH-2
alternative term: GAPDS
alternative term: HSD-35
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: GAPDHS
full name from nomenclature authority: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
NCBI GeneID: 26330
NCBI LocusTag: HSD35
gene map location: 19q13.12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004365 (EC: TAS, PMID: 10714828); GO_0005515 (EC: IPI, PMID: 16820410); GO_0005829 (EC: TAS); GO_0005975 (EC: TAS); GO_0006006 (EC: TAS); GO_0006094 (EC: TAS); GO_0006096 (EC: IEA); GO_0006096 (EC: TAS); GO_0007286 (EC: IEA); GO_0030317 (EC: ISS); GO_0031514 (EC: IEA); GO_0044281 (EC: TAS); GO_0045821 (EC: TAS, PMID: 10714828); GO_0050661 (EC: IEA); GO_0051287 (EC: IEA)
has PubMed association: PMID: 2793178; 4349855; 8125298; 9264469; 10655454; 10714828; 11225901; 11330647; 12477932; 15057824; 15342556; 15489334; 15507493; 16324157; 16700075; 16820410; 16832079; 17047026; 17192785; 17353931; 18298375; 18654987; 20534741; 20828617; 20833277; 20880607; 21269272; 21832049; 21995946; 23026046; 23306140; 23675907
description: glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
database cross reference: Ensembl:ENSG00000105679
database cross reference: HGNC:24864
database cross reference: HPRD:13566
database cross reference: MIM:609169
database cross reference: Vega:OTTHUMG00000182298

TNFRSF21
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: BM-018
alternative term: CD358
alternative term: DR6
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TNFRSF21
full name from nomenclature authority: tumor necrosis factor receptor superfamily, member 21
NCBI GeneID: 27242
NCBI LocusTag: UNQ437/PRO868
gene map location: 6p21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001783 (EC: ISS); GO_0002250 (EC: ISS); GO_0005515 (EC: IPI, PMID: 19225519); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 19654028); GO_0006915 (EC: IMP); GO_0006959 (EC: ISS); GO_0030424 (EC: IEA); GO_0030889 (EC: ISS); GO_0031226 (EC: ISS); GO_0031642 (EC: IMP); GO_0042130 (EC: ISS); GO_0042552 (EC: ISS); GO_0044255 (EC: TAS); GO_0044281 (EC: TAS); GO_0048713 (EC: ISS); GO_0050852 (EC: ISS); GO_0051402 (EC: ISS); GO_0071356 (EC: IDA, PMID: 19654028); GO_0097252 (EC: ISS); GO_2000663 (EC: ISS); GO_2000666 (EC: ISS); GO_2001180 (EC: ISS)
has PubMed association: PMID: 9714541; 11485735; 11714751; 11753679; 12477932; 12975309; 14574404; 14702039; 15301860; 15489334; 15623156; 16378686; 17962943; 18029348; 19165232; 19225519; 19322201; 19654028; 20237496; 20819778; 21337622; 21501873; 21900206; 22297296; 22525750; 22567163; 22761420; 24374337
description: tumor necrosis factor receptor superfamily, member 21
database cross reference: Ensembl:ENSG00000146072
database cross reference: HGNC:13469
database cross reference: HPRD:05759
database cross reference: MIM:605732
database cross reference: Vega:OTTHUMG00000014796

PCDH11X
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PCDH-X
alternative term: PCDH11
alternative term: PCDHX
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PCDH11X
full name from nomenclature authority: protocadherin 11 X-linked
NCBI GeneID: 27328
NCBI LocusTag: RP13-138P15.1
gene map location: Xq21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005509 (EC: IEA); GO_0005886 (EC: TAS, PMID: 10644456); GO_0005887 (EC: TAS, PMID: 10644456); GO_0007156 (EC: IEA); GO_0010923 (EC: IDA, PMID: 19389623)
has PubMed association: PMID: 8619474; 8889548; 9110174; 10644456; 10716726; 10718198; 10817752; 10835267; 11003707; 12815422; 14660691; 14727141; 15772651; 15905963; 16825765; 16874762; 18029348; 18187620; 18502103; 19125366; 19136949; 19389623; 19859901; 20523261; 20555150; 20574532; 20707987; 21276771; 22744706; 22808956; 23600975
description: protocadherin 11 X-linked
database cross reference: Ensembl:ENSG00000102290
database cross reference: HGNC:8656
database cross reference: HPRD:02215
database cross reference: MIM:300246
database cross reference: Vega:OTTHUMG00000021965

PYCARD
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ASC
alternative term: CARD5
alternative term: TMS
alternative term: TMS-1
alternative term: TMS1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PYCARD
full name from nomenclature authority: PYD and CARD domain containing
NCBI GeneID: 29108
gene map location: 16p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001773 (EC: IMP); GO_0002020 (EC: IEA); GO_0002218 (EC: IDA); GO_0002230 (EC: IEA); GO_0002277 (EC: ISS); GO_0002588 (EC: ISS); GO_0002821 (EC: IMP); GO_0005515 (EC: IPI, PMID: 11786556); GO_0005576 (EC: IEA); GO_0005634 (EC: IDA); GO_0005634 (EC: ISS); GO_0005730 (EC: IDA); GO_0005737 (EC: IDA); GO_0005737 (EC: NAS, PMID: 12019269); GO_0005739 (EC: IDA, PMID: 14730312); GO_0005783 (EC: IEA); GO_0005829 (EC: TAS); GO_0006915 (EC: TAS, PMID: 10567338); GO_0006919 (EC: NAS, PMID: 12019269); GO_0006954 (EC: IEA); GO_0007165 (EC: NAS, PMID: 12019269); GO_0008385 (EC: IDA, Qualifier: colocalizes_with, PMID: 12486103); GO_0008385 (EC: TAS, PMID: 12656673); GO_0008656 (EC: NAS, PMID: 12019269); GO_0010803 (EC: IMP, PMID: 14730312); GO_0030838 (EC: ISS); GO_0031647 (EC: ISS); GO_0032088 (EC: IMP, PMID: 16585594); GO_0032090 (EC: IPI, PMID: 15030775); GO_0032314 (EC: IEA); GO_0032611 (EC: IEA); GO_0032688 (EC: IMP, PMID: 19158675); GO_0032729 (EC: ISS); GO_0032755 (EC: ISS); GO_0032760 (EC: IMP, PMID: 16982856); GO_0033209 (EC: IDA, PMID: 12656673); GO_0035872 (EC: TAS); GO_0042104 (EC: ISS); GO_0042771 (EC: IMP, PMID: 14730312); GO_0042803 (EC: IDA, PMID: 15030775); GO_0043025 (EC: IEA); GO_0043065 (EC: IDA, PMID: 12646168); GO_0043124 (EC: IDA, PMID: 12486103); GO_0043280 (EC: IDA, PMID: 15030775); GO_0044325 (EC: IEA); GO_0044351 (EC: ISS); GO_0045087 (EC: TAS); GO_0046330 (EC: IMP); GO_0050718 (EC: IDA, PMID: 15030775); GO_0050727 (EC: IEA); GO_0050766 (EC: ISS); GO_0050829 (EC: IMP, PMID: 16982856); GO_0050870 (EC: IMP); GO_0051091 (EC: IDA, PMID: 19494289); GO_0051092 (EC: IDA, PMID: 12646168); GO_0051607 (EC: IDA); GO_0070374 (EC: IMP); GO_0071222 (EC: IDA, PMID: 12486103); GO_0071347 (EC: IDA, PMID: 12486103); GO_0071356 (EC: IDA, PMID: 12486103); GO_0071901 (EC: IDA, PMID: 12486103); GO_0072332 (EC: IMP, PMID: 14730312); GO_0072558 (EC: IDA, PMID: 12191486); GO_0072559 (EC: IDA, PMID: 15030775); GO_0090197 (EC: IMP); GO_0090200 (EC: IDA, PMID: 14730312); GO_0097…
has PubMed association: PMID: 10567338; 10847592; 11103776; 11103777; 11250163; 11374873; 11498534; 11733524; 11786556; 11967258; 12019269; 12054656; 12191486; 12477932; 12486103; 12553049; 12615073; 12646168; 12656673; 12776200; 12800194; 12949795; 14499617; 14634131; 14643031; 14702039; 14730312; 14985395; 15020601; 15030775; 15041718; 15456791; 15489334; 15641782; 15701651; 16037825; 16189514; 16425203; 16585594; 16715133; 16777061; 16848908; 16964285; 16982856; 17048097; 17178784; 17339483; 17418785; 17599361; 17964261; 17986858; 18263805; 18311798; 18348116; 18701507; 18791131; 18945969; 19158675; 19158676; 19158679; 19201894; 19223547; 19234215; 19258216; 19324871; 19443857; 19494289; 19636848; 19661336; 19759015; 19759850; 20020448; 20140741; 20148899; 20500518; 20808838; 20926535; 21036703; 21058222; 21104989; 21270336; 21487011; 21832064; 21890473; 22230750; 22286270; 22295065; 22732093; 22931929; 22934972; 23064206; 23066025; 23090995; 23110696; 23209292; 23839215
description: PYD and CARD domain containing
database cross reference: Ensembl:ENSG00000103490
database cross reference: HGNC:16608
database cross reference: HPRD:06020
database cross reference: MIM:606838
database cross reference: Vega:OTTHUMG00000176753

UBQLN1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DA41
alternative term: DSK2
alternative term: PLIC-1
alternative term: UBQN
alternative term: XDRP1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: UBQLN1
full name from nomenclature authority: ubiquilin 1
NCBI GeneID: 29979
gene map location: 9q22|9q21.2-q21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000502 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11076969); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT); GO_0005737 (EC: IDA); GO_0005737 (EC: IMP, PMID: 12634373); GO_0005783 (EC: IDA, PMID: 12095988); GO_0019900 (EC: IPI, PMID: 11853878); GO_0019904 (EC: IEA); GO_0031396 (EC: IDA, PMID: 12634373); GO_0034976 (EC: IMP, PMID: 12095988); GO_0043234 (EC: IDA); GO_0048471 (EC: IDA, PMID: 12095988); GO_0048471 (EC: NAS, PMID: 11853878); GO_0071456 (EC: IMP, PMID: 12095988); GO_1902175 (EC: IMP, PMID: 12095988)
has PubMed association: PMID: 9268694; 9303440; 10390159; 10549293; 10807547; 10983987; 11076969; 11230166; 11256614; 11528422; 11827521; 11853878; 12095988; 12477932; 12634373; 14662753; 14702039; 15004330; 15147878; 15231748; 15489334; 15492808; 15745979; 15975090; 16007098; 16091357; 16159959; 16189514; 16196087; 16214290; 16278862; 16302009; 16344560; 16461334; 16504527; 16526030; 16712842; 16713569; 16725228; 16799550; 16813565; 16815845; 16862145; 16945923; 17082820; 17098253; 17558393; 17603015; 17614368; 17709205; 17947293; 18199683; 18241885; 18307982; 18340109; 18467327; 18535780; 18781797; 18953672; 18985028; 19112176; 19148225; 19815544; 19822669; 20059542; 20350585; 20379614; 20529957; 20693704; 20972266; 21139048; 21143716; 21695056; 21852239; 21890473; 21906983; 21963094; 21987572; 21988832; 22053931; 22134777; 22233804; 22272618; 22428841; 22505724; 22766032; 22863883; 22939629; 23000965; 23246001; 23307288; 23383273; 23459205; 23649778; 23663107; 23774650; 23940030
description: ubiquilin 1
database cross reference: Ensembl:ENSG00000135018
database cross reference: HGNC:12508
database cross reference: HPRD:05440
database cross reference: MIM:605046
database cross reference: Vega:OTTHUMG00000020104

SLC40A1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FPN1
alternative term: HFE4
alternative term: IREG1
alternative term: MST079
alternative term: MTP1
alternative term: SLC11A3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SLC40A1
full name from nomenclature authority: solute carrier family 40 (iron-regulated transporter), member 1
NCBI GeneID: 30061
NCBI LocusTag: MSTP079
gene map location: 2q32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002260 (EC: IEA); GO_0003158 (EC: IEA); GO_0005381 (EC: IMP, PMID: 12091367); GO_0005515 (EC: IPI); GO_0005737 (EC: TAS, PMID: 10747949); GO_0005771 (EC: IEA); GO_0005886 (EC: IDA); GO_0005886 (EC: TAS); GO_0005887 (EC: IC, PMID: 12091367); GO_0006879 (EC: IMP, PMID: 12091367); GO_0006879 (EC: TAS); GO_0008021 (EC: IEA); GO_0009653 (EC: TAS, PMID: 10693807); GO_0016021 (EC: TAS, PMID: 10747949); GO_0034755 (EC: IMP, PMID: 12091367); GO_0043066 (EC: IEA); GO_0055085 (EC: TAS); GO_0060345 (EC: IEA); GO_0060586 (EC: IEA)
has PubMed association: PMID: 8125298; 10693807; 10747949; 10828623; 10882071; 11076863; 11230166; 11256614; 11431687; 11518736; 11774199; 11783942; 11897618; 11925460; 12091366; 12091367; 12123233; 12161425; 12376346; 12406098; 12477932; 12730114; 12857562; 12865285; 12873829; 14636642; 14636643; 14702039; 14757427; 14768003; 15075083; 15338274; 15466004; 15489334; 15489336; 15514116; 15692071; 15727899; 15831700; 15894659; 15897636; 15935710; 15942076; 15956209; 16169070; 16274220; 16280445; 16330432; 16344560; 16351644; 16381901; 16648237; 16885049; 17042772; 17135308; 17276706; 17383046; 17475779; 17486601; 17490902; 17847004; 17997113; 18160317; 18160816; 18177470; 18586377; 18646536; 18680715; 18782341; 18820912; 19066423; 19150361; 19234114; 19589941; 19610021; 19709084; 19759876; 19787796; 19846751; 19937651; 19958990; 20007457; 20230395; 20460119; 20564534; 20587610; 20655381; 20686179; 20688958; 20691492; 20739079; 21094556; 21126372; 21199650; 21231898; 21303654; 21396368; 21607294; 21890473; 22137264; 22170436; 22178646; 22246570; 22249207; 22357659; 22682226; 22682227; 22776295; 22890139; 23012398; 23065513; 23178444; 23335088; 23630227; 23640881; 23680252; 23846698
description: solute carrier family 40 (iron-regulated transporter), member 1
database cross reference: Ensembl:ENSG00000138449
database cross reference: HGNC:10909
database cross reference: HPRD:05229
database cross reference: MIM:604653
database cross reference: Vega:OTTHUMG00000132662

KCNIP3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CSEN
alternative term: DREAM
alternative term: KCHIP3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: KCNIP3
full name from nomenclature authority: Kv channel interacting protein 3, calsenilin
NCBI GeneID: 30818
gene map location: 2q21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IEA); GO_0003677 (EC: TAS, PMID: 10078534); GO_0003714 (EC: TAS, PMID: 10078534); GO_0005244 (EC: IEA); GO_0005267 (EC: IEA); GO_0005509 (EC: IEA); GO_0005634 (EC: IEA); GO_0005783 (EC: IEA); GO_0005794 (EC: IEA); GO_0005829 (EC: IEA); GO_0005886 (EC: IEA); GO_0006351 (EC: IEA); GO_0006357 (EC: TAS, PMID: 10078534); GO_0006886 (EC: IEA); GO_0006915 (EC: IEA); GO_0007165 (EC: TAS, PMID: 10900016); GO_0008022 (EC: IEA); GO_0015459 (EC: IEA); GO_0019233 (EC: IEA); GO_0030425 (EC: IEA); GO_0032993 (EC: IEA); GO_0043523 (EC: IEA); GO_0043565 (EC: IEA); GO_0043679 (EC: IEA); GO_0044325 (EC: IEA); GO_0048266 (EC: IEA); GO_0048306 (EC: IEA)
has PubMed association: PMID: 9771752; 9819380; 10078534; 10676964; 10854253; 10900016; 11072133; 11094064; 11259376; 11278424; 11535596; 11792319; 11988022; 12006572; 12198160; 12207970; 12217801; 12451113; 12477932; 12648752; 12829703; 12837631; 14702039; 14720210; 15086516; 15184042; 15489334; 15770150; 15815621; 16112838; 16177826; 16189514; 16306395; 16840549; 17102134; 17189291; 17962406; 18187620; 18269347; 18393943; 18507845; 18628663; 18664571; 18957440; 19299442; 19730683; 20211142; 21070824; 21216226; 21813705; 21852538; 22730276; 23019329; 23187802; 23300953; 23692269; 23786773
description: Kv channel interacting protein 3, calsenilin
database cross reference: Ensembl:ENSG00000115041
database cross reference: HGNC:15523
database cross reference: HPRD:05232
database cross reference: MIM:604662
database cross reference: Vega:OTTHUMG00000130392

APH1A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: 6530402N02Rik
alternative term: APH-1
alternative term: APH-1A
alternative term: CGI-78
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APH1A
full name from nomenclature authority: APH1A gamma secretase subunit
NCBI GeneID: 51107
NCBI LocusTag: RP4-790G17.3
gene map location: 1p36.13-q31.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001656 (EC: IEA); GO_0004175 (EC: IEA); GO_0005515 (EC: IPI, PMID: 12297508); GO_0005783 (EC: IDA, PMID: 15274632); GO_0005789 (EC: IEA); GO_0005794 (EC: IDA, PMID: 15274632); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 15274632); GO_0006509 (EC: IDA, PMID: 15274632); GO_0007219 (EC: TAS); GO_0007220 (EC: IMP, PMID: 12297508); GO_0007220 (EC: TAS, PMID: 15274632); GO_0016485 (EC: IDA, PMID: 15274632); GO_0031293 (EC: IMP, PMID: 12297508); GO_0031293 (EC: TAS); GO_0032580 (EC: IEA); GO_0042987 (EC: IMP, PMID: 12297508); GO_0042987 (EC: TAS, PMID: 15274632); GO_0043065 (EC: TAS); GO_0043085 (EC: IDA, PMID: 15274632); GO_0048011 (EC: TAS); GO_0097190 (EC: TAS)
has PubMed association: PMID: 10810093; 12110170; 12297508; 12471034; 12477932; 12522139; 12679784; 12740439; 12763021; 12787561; 12843241; 12857757; 12917438; 12972157; 12975309; 14572442; 14593096; 14627705; 14702039; 15210705; 15257293; 15274632; 15286082; 15322084; 15322109; 15474363; 15489334; 15629423; 15721744; 16303743; 16344560; 16630834; 16641999; 16757808; 17059559; 17207965; 17986144; 18801744; 19028695; 19322201; 19368855; 19369254; 20145246; 20299451; 20379614; 20674680; 21123562; 21443683; 21890473; 21988832; 23253155; 23291095; 23864651
description: APH1A gamma secretase subunit
database cross reference: Ensembl:ENSG00000117362
database cross reference: HGNC:29509
database cross reference: MIM:607629
database cross reference: Vega:OTTHUMG00000012545

LEF1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LEF-1
alternative term: TCF10
alternative term: TCF1ALPHA
alternative term: TCF7L3
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LEF1
full name from nomenclature authority: lymphoid enhancer-binding factor 1
NCBI GeneID: 51176
gene map location: 4q23-q25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IEA); GO_0000977 (EC: IDA); GO_0001228 (EC: IMP); GO_0001569 (EC: IBA); GO_0001649 (EC: IEP); GO_0001755 (EC: IBA); GO_0001756 (EC: IBA); GO_0001837 (EC: ISS); GO_0002040 (EC: IBA); GO_0003677 (EC: ISS); GO_0003682 (EC: IBA); GO_0003700 (EC: IDA, PMID: 11751639); GO_0003705 (EC: IBA); GO_0005515 (EC: IPI, PMID: 12192039); GO_0005634 (EC: IC, PMID: 9308964); GO_0005634 (EC: IDA, PMID: 17063141); GO_0005654 (EC: TAS); GO_0005667 (EC: IDA, PMID: 11751639); GO_0005737 (EC: IDA, PMID: 19402906); GO_0006366 (EC: IDA); GO_0008013 (EC: IDA, PMID: 9488439); GO_0008013 (EC: IPI, PMID: 10825188); GO_0008013 (EC: TAS, PMID: 16344550); GO_0008134 (EC: IEA); GO_0008284 (EC: IDA, PMID: 19351848); GO_0008301 (EC: ISS); GO_0010628 (EC: IDA, PMID: 16344550); GO_0010718 (EC: IMP); GO_0016055 (EC: IDA, PMID: 10644691); GO_0016202 (EC: IBA); GO_0021542 (EC: IBA); GO_0021854 (EC: IBA); GO_0021861 (EC: IBA); GO_0021873 (EC: IBA); GO_0021879 (EC: IBA); GO_0021943 (EC: IBA); GO_0022407 (EC: IEA); GO_0022408 (EC: IDA, PMID: 19653274); GO_0022409 (EC: IDA, PMID: 19653274); GO_0030223 (EC: IMP, PMID: 17063141); GO_0030284 (EC: IDA, PMID: 18794125); GO_0030307 (EC: IMP); GO_0030326 (EC: IBA); GO_0030331 (EC: IDA, PMID: 18794125); GO_0030335 (EC: IDA, PMID: 19653274); GO_0030335 (EC: IMP); GO_0030509 (EC: IBA); GO_0030854 (EC: IDA, PMID: 19620402); GO_0030854 (EC: IMP); GO_0030879 (EC: IBA); GO_0032696 (EC: IDA, PMID: 18445004); GO_0032713 (EC: IDA, PMID: 18445004); GO_0032714 (EC: IDA, PMID: 18445004); GO_0032993 (EC: IDA, PMID: 10825188); GO_0033153 (EC: IEA); GO_0035326 (EC: IDA, PMID: 7657162); GO_0042100 (EC: IBA); GO_0042393 (EC: IPI); GO_0042475 (EC: IEA); GO_0043027 (EC: IMP); GO_0043066 (EC: IMP); GO_0043154 (EC: IMP); GO_0043392 (EC: IDA, PMID: 18445004); GO_0043401 (EC: IDA, PMID: 18794125); GO_0043565 (EC: IDA, PMID: 10825188); GO_0043586 (EC: IEA); GO_0043923 (EC: IDA, PMID: 7657162); GO_0043966 (EC: IMP); GO_0043967 (EC: IMP); GO_0044212 (EC: IDA, PMID: 16344550); G…
has PubMed association: PMID: 1783375; 1827423; 1989880; 2010090; 7537238; 7657162; 7958926; 8125298; 8631802; 8757136; 9119227; 9119228; 9308964; 9419974; 9488439; 9671491; 9751710; 9843967; 10644691; 10756202; 10825188; 10890911; 10958684; 11266540; 11326276; 11440173; 11604490; 11696550; 11731474; 11751639; 11835406; 12032083; 12048204; 12052822; 12077367; 12095232; 12161443; 12183361; 12192039; 12235165; 12408825; 12446687; 12477932; 12551949; 12556497; 12589056; 12707037; 12748295; 12901858; 14661054; 14759258; 14990565; 15000148; 15143193; 15194563; 15245424; 15489334; 15525529; 15684397; 15728254; 15750622; 15756419; 15768032; 16014379; 16120831; 16142310; 16204248; 16228014; 16344550; 16415175; 16424171; 16474850; 16510874; 16510875; 16565724; 16714285; 16809766; 17063141; 17132729; 17240357; 17360796; 17466981; 17585052; 17785436; 17785445; 17947518; 17980157; 18029348; 18077326; 18296023; 18316418; 18445004; 18579517; 18615589; 18636547; 18794125; 18936100; 19060910; 19079342; 19131506; 19244345; 19304756; 19351848; 19402906; 19453261; 19460168; 19576624; 19590514; 19620402; 19653274; 19784072; 20019092; 20098615; 20124220; 20194509; 20211142; 20219685; 20332099; 20363964; 20595513; 20634891; 20676368; 21190562; 21270130; 21282610; 21285352; 21383983; 21444716; 21471213; 21527502; 21544627; 21599871; 21685909; 21744004; 21781440; 21795403; 21980470; 21988832; 21998751; 22020335; 22111711; 22261717; 22291604; 22359570; 22436613; 22505724; 22507326; 22639890; 22686279; 22766851; 22769578; 22792274; 22815426; 22837378; 22905168; 23001182; 23068607; 23224985; 23325550; 23375451; 23572277; 23770605; 23913826
description: lymphoid enhancer-binding factor 1
database cross reference: Ensembl:ENSG00000138795
database cross reference: HGNC:6551
database cross reference: HPRD:01075
database cross reference: MIM:153245
database cross reference: Vega:OTTHUMG00000131809

TLR8
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD288
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TLR8
full name from nomenclature authority: toll-like receptor 8
NCBI GeneID: 51311
NCBI LocusTag: UNQ249/PRO286
gene map location: Xp22
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: TAS); GO_0002224 (EC: TAS); GO_0002282 (EC: IEA); GO_0003677 (EC: IDA, PMID: 16123302); GO_0003723 (EC: TAS, PMID: 16123302); GO_0003725 (EC: IDA, PMID: 16111635); GO_0003727 (EC: IDA, PMID: 14976262); GO_0004872 (EC: NAS, PMID: 12032557); GO_0005789 (EC: TAS); GO_0006954 (EC: IEA); GO_0007249 (EC: IDA, PMID: 12032557); GO_0008144 (EC: IEA); GO_0009615 (EC: IDA, PMID: 12032557); GO_0010008 (EC: TAS); GO_0016021 (EC: IC, PMID: 12032557); GO_0016064 (EC: TAS, PMID: 16123302); GO_0034162 (EC: TAS); GO_0036020 (EC: TAS); GO_0045078 (EC: IDA, PMID: 16286015); GO_0045087 (EC: NAS, PMID: 12032557); GO_0045087 (EC: TAS); GO_0045089 (EC: IDA, PMID: 16123302); GO_0045356 (EC: IDA, PMID: 16286015); GO_0045359 (EC: IDA, PMID: 16286015); GO_0045416 (EC: IMP, PMID: 16188996); GO_0051607 (EC: IMP, PMID: 16188996); GO_0052033 (EC: IEA); GO_0071260 (EC: IEP, PMID: 19593445)
has PubMed association: PMID: 9435236; 11022119; 11022120; 11607792; 11782555; 11909637; 12032557; 12477932; 12724322; 12975309; 14625308; 14976262; 15276183; 15489334; 16008579; 16024789; 16025564; 16111635; 16123302; 16188996; 16286015; 16303743; 16482509; 16737960; 16857668; 16935934; 17023556; 17040905; 17090647; 17301562; 17698957; 17703412; 17724596; 17868034; 17932028; 17964520; 18394314; 18406377; 18431484; 18438411; 18605904; 18682521; 18686608; 18810425; 18818748; 18927625; 18942751; 18985439; 18985539; 19017992; 19019335; 19028959; 19164127; 19164128; 19258923; 19265114; 19381167; 19406482; 19437550; 19454678; 19505919; 19527497; 19527514; 19593445; 19614650; 19637197; 19841637; 19850743; 19913121; 19915052; 19924287; 20004021; 20100933; 20124101; 20190752; 20194452; 20227302; 20237413; 20237496; 20364151; 20399690; 20412752; 20503287; 20588308; 20595247; 20628086; 20652908; 20674764; 20829351; 20832340; 20946625; 20977567; 21061265; 21092001; 21321205; 21354862; 21499082; 21677671; 21734241; 21947541; 21977996; 22022576; 22065095; 22164301; 22196370; 22210629; 22243920; 22289837; 22340042; 22363482; 22393042; 22525943; 22730373; 22768144; 22795647; 22857391; 23221735; 23223421; 23369718; 23386618; 23425350; 23520111; 23685782; 23787171; 23906644; 24046015; 24227841; 24254490
description: toll-like receptor 8
database cross reference: Ensembl:ENSG00000101916
database cross reference: HGNC:15632
database cross reference: HPRD:02296
database cross reference: MIM:300366
database cross reference: Vega:OTTHUMG00000021145

NME8
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CILD6
alternative term: NM23-H8
alternative term: SPTRX2
alternative term: TXNDC3
alternative term: sptrx-2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NME8
full name from nomenclature authority: NME/NM23 family member 8
NCBI GeneID: 51314
gene map location: 7p14.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004550 (EC: IEA); GO_0005524 (EC: IEA); GO_0005737 (EC: IEA); GO_0006183 (EC: IEA); GO_0006228 (EC: IEA); GO_0006241 (EC: IEA); GO_0007275 (EC: IEA); GO_0007283 (EC: IEA); GO_0030154 (EC: IEA); GO_0045454 (EC: IEA)
has PubMed association: PMID: 11574167; 11737268; 11768308; 12477932; 15489334; 16642435; 17304710; 17360648; 18029348; 18471322; 19852809; 20237151; 20301301; 20379614; 21832049; 22504420
description: NME/NM23 family member 8
database cross reference: Ensembl:ENSG00000086288
database cross reference: HGNC:16473
database cross reference: HPRD:16243
database cross reference: MIM:607421
database cross reference: Vega:OTTHUMG00000023716

CSAD
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CSD
alternative term: PCAP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CSAD
full name from nomenclature authority: cysteine sulfinic acid decarboxylase
NCBI GeneID: 51380
gene map location: 12q13.11-q14.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000096 (EC: TAS); GO_0000098 (EC: TAS); GO_0004782 (EC: IEA); GO_0030170 (EC: IEA); GO_0034641 (EC: TAS); GO_0042412 (EC: IEA); GO_0044281 (EC: TAS)
has PubMed association: PMID: 11752456; 11997111; 12477932; 14702039; 15489334; 16344560; 21900206; 22718265; 23251661; 24250222
description: cysteine sulfinic acid decarboxylase
database cross reference: Ensembl:ENSG00000139631
database cross reference: HGNC:18966
database cross reference: HPRD:16763
database cross reference: Vega:OTTHUMG00000048076

SIRT7
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SIR2L7
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SIRT7
full name from nomenclature authority: sirtuin 7
NCBI GeneID: 51547
gene map location: 17q25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IDA); GO_0003682 (EC: IDA); GO_0005515 (EC: IPI, PMID: 19174463); GO_0005730 (EC: IDA, PMID: 16079181); GO_0005731 (EC: IDA, PMID: 19174463); GO_0005737 (EC: IEA); GO_0007072 (EC: IMP, PMID: 19174463); GO_0009303 (EC: IMP, PMID: 19174463); GO_0046872 (EC: IEA); GO_0070403 (EC: IEA); GO_0070932 (EC: IDA); GO_0070933 (EC: IDA); GO_0097372 (EC: IDA)
has PubMed association: PMID: 9776767; 10873683; 11953824; 12454780; 12477932; 14702039; 15489334; 16079181; 16169070; 16525639; 16618798; 17003781; 19174463; 20375098; 21832049; 22147730; 22586326; 22722849; 23079745; 23680022; 23750001; 24207024; 24250222
description: sirtuin 7
database cross reference: Ensembl:ENSG00000187531
database cross reference: HGNC:14935
database cross reference: HPRD:12094
database cross reference: MIM:606212
database cross reference: Vega:OTTHUMG00000177957

SIRT6
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: SIR2L6
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SIRT6
full name from nomenclature authority: sirtuin 6
NCBI GeneID: 51548
gene map location: 19p13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003950 (EC: TAS, PMID: 17456799); GO_0003956 (EC: ISS); GO_0005515 (EC: IPI, PMID: 19135889); GO_0005634 (EC: ISS); GO_0005654 (EC: IDA, PMID: 16079181); GO_0005724 (EC: IDA, PMID: 18337721); GO_0005730 (EC: IDA, Qualifier: NOT, PMID: 16079181); GO_0006471 (EC: ISS); GO_0006471 (EC: TAS, PMID: 17456799); GO_0008270 (EC: ISS); GO_0010569 (EC: IDA, PMID: 19135889); GO_0016575 (EC: ISS); GO_0017136 (EC: ISS); GO_0046969 (EC: IDA, PMID: 18337721); GO_0070403 (EC: ISS); GO_0070932 (EC: IDA, PMID: 18337721)
has PubMed association: PMID: 8125298; 10873683; 12477932; 14702039; 15057824; 15489334; 15719057; 16079181; 16169070; 16189514; 17131381; 17456799; 18242175; 18337721; 18388907; 19135889; 19625767; 20157594; 20375098; 20829486; 21224216; 21349544; 21362626; 21502801; 21680843; 21847107; 21890473; 21900206; 21900744; 21906983; 21981042; 22087257; 22505724; 22700961; 22743824; 22753495; 22770219; 22792191; 22939629; 23041974; 23075334; 23086953; 23132960; 23136298; 23201774; 23217706; 23514751; 23526469; 23552949; 23653361; 23860128; 24043303; 24052263; 24250222; 24367027
description: sirtuin 6
database cross reference: Ensembl:ENSG00000077463
database cross reference: HGNC:14934
database cross reference: HPRD:12093
database cross reference: MIM:606211
database cross reference: Vega:OTTHUMG00000181847

VPS29
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DC15
alternative term: PEP11
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: VPS29
full name from nomenclature authority: vacuolar protein sorting 29 homolog (S. cerevisiae)
NCBI GeneID: 51699
NCBI LocusTag: DC7
gene map location: 12q24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004647 (EC: IEA); GO_0005737 (EC: IDA); GO_0005768 (EC: IDA); GO_0005829 (EC: TAS); GO_0010008 (EC: IEA); GO_0015031 (EC: IEA); GO_0043231 (EC: IDA); GO_0046872 (EC: IEA)
has PubMed association: PMID: 8889549; 9700157; 11062004; 11076863; 11102511; 11230166; 11256614; 12477932; 15247922; 15282546; 15489334; 15489336; 15788412; 16169070; 16381901; 16712791; 16737443; 17101778; 17891154; 19531583; 20923837; 21629666; 21832049; 21900206; 21906983; 22354992; 22863883; 22939629; 23452853; 23455922
description: vacuolar protein sorting 29 homolog (S. cerevisiae)
database cross reference: Ensembl:ENSG00000111237
database cross reference: HGNC:14340
database cross reference: HPRD:09499
database cross reference: MIM:606932
database cross reference: Vega:OTTHUMG00000169527

INPP5K
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: PPS
alternative term: SKIP
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: INPP5K
full name from nomenclature authority: inositol polyphosphate-5-phosphatase K
NCBI GeneID: 51763
gene map location: 17p13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 17
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001701 (EC: IEA); GO_0001726 (EC: IDA, PMID: 12536145); GO_0001933 (EC: ISS); GO_0004445 (EC: IEA); GO_0005000 (EC: ISS); GO_0005515 (EC: IPI, PMID: 16002321); GO_0005634 (EC: IDA, PMID: 18774950); GO_0005737 (EC: ISS); GO_0005783 (EC: IDA, PMID: 12536145); GO_0005802 (EC: IDA, PMID: 12556481); GO_0005829 (EC: IDA, PMID: 10753883); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA, PMID: 12556481); GO_0005979 (EC: ISS); GO_0006469 (EC: IDA, PMID: 12556481); GO_0006644 (EC: TAS); GO_0006661 (EC: TAS); GO_0007186 (EC: ISS); GO_0010801 (EC: IDA, PMID: 12556481); GO_0010829 (EC: IDA, PMID: 12556481); GO_0016020 (EC: IDA, PMID: 12536145); GO_0016311 (EC: IDA, PMID: 18573875); GO_0016311 (EC: IMP, PMID: 18774950); GO_0016312 (EC: IDA, PMID: 10753883); GO_0030036 (EC: NAS, PMID: 10753883); GO_0032587 (EC: IDA, PMID: 12556481); GO_0032869 (EC: IDA, PMID: 12556481); GO_0032870 (EC: ISS); GO_0033137 (EC: IDA, PMID: 12556481); GO_0034485 (EC: IDA); GO_0034594 (EC: IDA, PMID: 12556481); GO_0034595 (EC: IMP, PMID: 18774950); GO_0035305 (EC: ISS); GO_0035810 (EC: ISS); GO_0042577 (EC: NAS, PMID: 10753883); GO_0042593 (EC: ISS); GO_0043005 (EC: IDA, PMID: 10753883); GO_0043407 (EC: IDA, PMID: 12556481); GO_0043922 (EC: IDA, PMID: 18774950); GO_0044281 (EC: TAS); GO_0045719 (EC: IDA, PMID: 12556481); GO_0045869 (EC: IDA, PMID: 18774950); GO_0045892 (EC: ISS); GO_0045893 (EC: ISS); GO_0046030 (EC: IDA, PMID: 10753883); GO_0046627 (EC: IDA, PMID: 12556481); GO_0046855 (EC: IDA, PMID: 12536145); GO_0046856 (EC: IDA, PMID: 12536145); GO_0048471 (EC: IDA, PMID: 18774950); GO_0051497 (EC: IDA, PMID: 12556481); GO_0051898 (EC: IDA, PMID: 12556481); GO_0051926 (EC: IDA, PMID: 12556481); GO_0052658 (EC: IEA); GO_0052659 (EC: IEA); GO_0071320 (EC: ISS); GO_0071356 (EC: IDA); GO_0071364 (EC: IDA); GO_0072661 (EC: ISS); GO_0090315 (EC: IDA, PMID: 12556481); GO_0097178 (EC: IDA, PMID: 12556481); GO_2000466 (EC: ISS); GO_2001153 (EC: ISS)
has PubMed association: PMID: 8968499; 8968500; 10753883; 11509665; 12477932; 12536145; 12556481; 12621583; 16002321; 16189514; 17353931; 18573875; 18774950; 21890473; 21900206; 21903422; 21988832; 22751929; 22815484; 24250222
description: inositol polyphosphate-5-phosphatase K
database cross reference: Ensembl:ENSG00000132376
database cross reference: HGNC:33882
database cross reference: HPRD:08489
database cross reference: MIM:607875
database cross reference: Vega:OTTHUMG00000150648

NUP54
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NUP54
full name from nomenclature authority: nucleoporin 54kDa
NCBI GeneID: 53371
gene map location: 4q21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000278 (EC: TAS); GO_0005487 (EC: IEA); GO_0005635 (EC: TAS); GO_0005643 (EC: IEA); GO_0005654 (EC: TAS, PMID: 8707840); GO_0005737 (EC: TAS, PMID: 8707840); GO_0005975 (EC: TAS); GO_0006605 (EC: IEA); GO_0007077 (EC: TAS); GO_0008645 (EC: TAS); GO_0010827 (EC: TAS); GO_0015758 (EC: TAS); GO_0016032 (EC: TAS); GO_0019221 (EC: TAS); GO_0031965 (EC: IEA); GO_0044281 (EC: TAS); GO_0051028 (EC: IEA); GO_0055085 (EC: TAS)
has PubMed association: PMID: 2050741; 7531196; 8125298; 8589458; 8707840; 9582382; 10395558; 10546895; 10601273; 10931946; 11266456; 12228227; 12477932; 14702039; 15489334; 16189514; 16344560; 16651408; 17623298; 19275582; 19458171; 20012529; 20936779; 21139048; 21489275; 21890473; 21906983; 21963094; 21987572; 22939629; 23000965
description: nucleoporin 54kDa

TLR9
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD289
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TLR9
full name from nomenclature authority: toll-like receptor 9
NCBI GeneID: 54106
NCBI LocusTag: UNQ5798/PRO19605
gene map location: 3p21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000139 (EC: TAS); GO_0002224 (EC: TAS); GO_0002237 (EC: TAS, PMID: 15356140); GO_0002755 (EC: IEA); GO_0004888 (EC: IEA); GO_0005149 (EC: IPI, PMID: 12925853); GO_0005576 (EC: NAS, PMID: 11130078); GO_0005737 (EC: IDA, PMID: 19740627); GO_0005764 (EC: ISS); GO_0005768 (EC: ISS); GO_0005783 (EC: ISS); GO_0005789 (EC: TAS); GO_0005886 (EC: IDA, PMID: 19740627); GO_0006954 (EC: IEA); GO_0007252 (EC: IDA, PMID: 19740627); GO_0008286 (EC: TAS); GO_0010008 (EC: TAS); GO_0016021 (EC: IEA); GO_0016323 (EC: IDA, PMID: 17128265); GO_0016324 (EC: IDA, PMID: 17128265); GO_0030277 (EC: ISS); GO_0032009 (EC: ISS); GO_0032088 (EC: IDA, PMID: 17128265); GO_0032715 (EC: ISS); GO_0032717 (EC: IDA, PMID: 17128265); GO_0032722 (EC: IDA, PMID: 19740627); GO_0032728 (EC: ISS); GO_0032733 (EC: ISS); GO_0032735 (EC: ISS); GO_0032741 (EC: ISS); GO_0032755 (EC: IDA, PMID: 19740627); GO_0032757 (EC: IDA, PMID: 17128265); GO_0032760 (EC: ISS); GO_0034122 (EC: IDA, PMID: 17128265); GO_0034123 (EC: IDA, PMID: 17128265); GO_0034162 (EC: TAS); GO_0035197 (EC: IMP, PMID: 15723075); GO_0036020 (EC: TAS); GO_0042346 (EC: IDA, PMID: 19740627); GO_0042742 (EC: NAS, PMID: 11130078); GO_0043123 (EC: IDA, PMID: 17128265); GO_0043507 (EC: IDA, PMID: 17128265); GO_0045078 (EC: IDA, PMID: 16286015); GO_0045087 (EC: TAS, PMID: 15356140); GO_0045356 (EC: IDA, PMID: 16286015); GO_0045359 (EC: IDA, PMID: 16286015); GO_0045944 (EC: ISS); GO_0046330 (EC: IC, PMID: 17128265); GO_0050707 (EC: IEA); GO_0050729 (EC: IC, PMID: 19740627); GO_0050829 (EC: IMP); GO_0051092 (EC: IDA, PMID: 17128265); GO_0051770 (EC: ISS)
has PubMed association: PMID: 9435236; 11022119; 11022120; 11130078; 11561001; 11564765; 11782555; 11867692; 11909637; 11970999; 11976718; 12477932; 12560217; 12573264; 12600829; 12660731; 12689944; 12724322; 12734363; 12778475; 12867418; 12925853; 12941697; 12975309; 14625308; 14694183; 14716310; 14751759; 14987294; 15107846; 15153500; 15207506; 15276183; 15294971; 15307186; 15356140; 15489334; 15585868; 15607737; 15631627; 15723075; 15730519; 15790341; 15860583; 15878652; 16002719; 16024265; 16024789; 16125159; 16164440; 16230478; 16237063; 16286015; 16371473; 16394009; 16424230; 16428738; 16437636; 16575840; 16608528; 16731773; 16779724; 16847112; 16849519; 16864658; 16920494; 16951309; 16971956; 16990271; 17000223; 17040905; 17075805; 17128265; 17142771; 17145922; 17192395; 17229603; 17258734; 17292969; 17295441; 17301562; 17325049; 17328813; 17344245; 17360657; 17373717; 17440926; 17469139; 17473064; 17474147; 17482427; 17516623; 17534115; 17573724; 17636117; 17703412; 17768129; 17854429; 17854755; 17878374; 17893430; 17894360; 17914947; 17932028; 17964520; 17984204; 17986857; 18036648; 18092352; 18160420; 18208876; 18215354; 18253698; 18262306; 18275280; 18312481; 18318750; 18332208; 18394314; 18406377; 18437017; 18524824; 18535206; 18539711; 18568766; 18595521; 18606688; 18633634; 18686608; 18763053; 18769358; 18776126; 18776592; 18806803; 18810425; 18818748; 18832675; 18841790; 18922969; 18946062; 19019335; 19033535; 19034349; 19050243; 19079358; 19096003; 19120473; 19129482; 19130296; 19201477; 19211891; 19247692; 19254290; 19258923; 19264973; 19275920; 19284650; 19289178; 19297619; 19299739; 19317913; 19319670; 19337058; 19362685; 19367581; 19390575; 19401392; 19406482; 19423540; 19459480; 19505919; 19513613; 19527514; 19539691; 19564354; 19578108; 19601804; 19618291; 19620253; 19627277; 19639721; 19714766; 19723394; 19724876; 19740627; 19745833; 19771452; 19789190; 19794067; 19796535; 19809335; 19810822; 19840968; 19844589; 19854217; 19855253; 19903791; 19906293; 19913121; 19914…
description: toll-like receptor 9
database cross reference: Ensembl:ENSG00000239732
database cross reference: HGNC:15633
database cross reference: HPRD:05685
database cross reference: MIM:605474
database cross reference: Vega:OTTHUMG00000158106

CYCS
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CYC
alternative term: HCS
alternative term: THC4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CYCS
full name from nomenclature authority: cytochrome c, somatic
NCBI GeneID: 54205
gene map location: 7p15.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000159 (EC: TAS, PMID: 8206937); GO_0004722 (EC: TAS, Qualifier: contributes_to, PMID: 8206937); GO_0005506 (EC: IEA); GO_0005515 (EC: IPI, PMID: 10206961); GO_0005634 (EC: IDA); GO_0005739 (EC: IDA); GO_0005743 (EC: TAS); GO_0005758 (EC: TAS, PMID: 8689682); GO_0005829 (EC: IMP, PMID: 8689682); GO_0005829 (EC: TAS); GO_0006309 (EC: IMP, PMID: 8689682); GO_0006915 (EC: TAS); GO_0008635 (EC: TAS, PMID: 9267021); GO_0016311 (EC: TAS, PMID: 8206937); GO_0020037 (EC: TAS, PMID: 9515723); GO_0022904 (EC: TAS); GO_0044237 (EC: TAS); GO_0044281 (EC: TAS); GO_0045155 (EC: IDA, PMID: 8689682); GO_0045333 (EC: TAS, PMID: 10383829); GO_0070469 (EC: IEA); GO_0097193 (EC: TAS)
has PubMed association: PMID: 199233; 1309738; 2153405; 2580882; 2844747; 2849112; 4403130; 6087732; 6088481; 6251869; 6262312; 6270113; 8206937; 8663341; 8689682; 9027314; 9192670; 9267021; 9390557; 9515723; 9615439; 9760250; 9847074; 9922454; 10082581; 10206961; 10383829; 10506125; 10622714; 10625700; 10683230; 10801801; 10818086; 10980706; 11076863; 11193032; 11230166; 11256614; 11462036; 11737208; 11739707; 11784858; 11790791; 11839755; 12019321; 12101247; 12147322; 12243190; 12404116; 12416732; 12477932; 12555167; 12690205; 12853948; 12909341; 13933734; 14063298; 14702039; 15033690; 15254227; 15489334; 15489336; 15691386; 15698476; 16196087; 16381901; 16520893; 16713569; 16934433; 17353931; 17409234; 18345000; 18417609; 18825408; 18973553; 18976975; 19029908; 19172527; 19404857; 19458171; 19640329; 19770576; 19812265; 19851871; 19875445; 19895853; 20227384; 20237496; 20877624; 20972266; 21139048; 21192676; 21319273; 21448217; 21693764; 21706253; 21712378; 21751259; 21869827; 21890473; 21906983; 22102269; 22157762; 22184220; 22192356; 22216281; 22320973; 22363611; 22505724; 22552851; 22623428; 22632162; 22939629; 23000965; 23070294; 23150584; 23207240; 23334161; 23535033; 24163370; 24250222
description: cytochrome c, somatic
database cross reference: HGNC:19986
database cross reference: HPRD:00479
database cross reference: MIM:123970

TREM2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: TREM-2
alternative term: Trem2a
alternative term: Trem2b
alternative term: Trem2c
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TREM2
full name from nomenclature authority: triggering receptor expressed on myeloid cells 2
NCBI GeneID: 54209
NCBI LocusTag: RP1-238O23.2
gene map location: 6p21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001530 (EC: IEA); GO_0004872 (EC: TAS, PMID: 10799849); GO_0005576 (EC: IEA); GO_0005886 (EC: TAS); GO_0006959 (EC: TAS, PMID: 10799849); GO_0007411 (EC: TAS); GO_0016021 (EC: IEA); GO_0045087 (EC: TAS)
has PubMed association: PMID: 10799849; 12080485; 12477932; 12645956; 12754369; 12913093; 12925681; 15489334; 15966270; 16505336; 16715077; 17530208; 18546367; 18551625; 19019460; 19079182; 19230638; 19457124; 19913121; 20301376; 20421649; 20628086; 20640189; 21834902; 22939635; 23150908; 23150934; 23380991; 23391427; 23407992; 23533697; 23582655; 23721075; 23759145; 23800361; 23855982; 23855984; 23870839; 24078628; 24131187
description: triggering receptor expressed on myeloid cells 2
database cross reference: Ensembl:ENSG00000095970
database cross reference: HGNC:17761
database cross reference: HPRD:05473
database cross reference: MIM:605086
database cross reference: Vega:OTTHUMG00000014671

TREM1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CD354
alternative term: TREM-1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: TREM1
full name from nomenclature authority: triggering receptor expressed on myeloid cells 1
NCBI GeneID: 54210
gene map location: 6p21.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004872 (EC: TAS, PMID: 10799849); GO_0005576 (EC: IEA); GO_0005886 (EC: TAS); GO_0006959 (EC: TAS, PMID: 10799849); GO_0007596 (EC: TAS); GO_0016021 (EC: IEA); GO_0035556 (EC: TAS, PMID: 10799849); GO_0045087 (EC: TAS); GO_0050900 (EC: TAS)
has PubMed association: PMID: 8125298; 10799849; 11323674; 11922939; 12477932; 12645956; 12646648; 12792857; 14574404; 14656437; 15067076; 15309732; 15351648; 15489334; 15585833; 16344560; 16437719; 16733861; 17008237; 17202378; 17277102; 17336301; 17452516; 17505044; 17558349; 17634956; 17659879; 17729416; 17785845; 18008257; 18317529; 18396215; 18628981; 18634145; 18656898; 18818748; 19019335; 19109693; 19230638; 19251433; 19396532; 19479878; 19484952; 19527514; 19591072; 19596984; 19913121; 19917159; 19923060; 20140262; 20156945; 20237496; 20375613; 20628086; 20640189; 21148811; 21306476; 21393102; 21421043; 21555403; 21701149; 21763322; 21855288; 21906983; 21910175; 21942576; 21967868; 21976106; 22179409; 22417086; 22422501; 22459945; 22642593; 22721842; 22798017; 22829716; 22996209; 23046618; 23364598; 23414215; 23436478; 23468854; 23734253; 23861562; 23880194; 24605677
description: triggering receptor expressed on myeloid cells 1
database cross reference: Ensembl:ENSG00000124731
database cross reference: HGNC:17760
database cross reference: HPRD:05472
database cross reference: MIM:605085
database cross reference: Vega:OTTHUMG00000014674

ZCWPW1
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ZCW1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ZCWPW1
full name from nomenclature authority: zinc finger, CW type with PWWP domain 1
NCBI GeneID: 55063
gene map location: 7q22.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 7
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0008270 (EC: IEA)
has PubMed association: PMID: 11230166; 12477932; 14607086; 14702039; 15489334; 20826339; 24250222
description: zinc finger, CW type with PWWP domain 1
database cross reference: Ensembl:ENSG00000078487
database cross reference: HGNC:23486
database cross reference: HPRD:15706
database cross reference: Vega:OTTHUMG00000159537

VPS35
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MEM3
alternative term: PARK17
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: VPS35
full name from nomenclature authority: vacuolar protein sorting 35 homolog (S. cerevisiae)
NCBI GeneID: 55737
NCBI LocusTag: TCCCTA00141
gene map location: 16q12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 11102511); GO_0005765 (EC: IDA, PMID: 17897319); GO_0005768 (EC: IDA); GO_0005829 (EC: IDA, PMID: 11102511); GO_0005829 (EC: TAS); GO_0008219 (EC: IEA); GO_0015031 (EC: IEA); GO_0030904 (EC: IEA); GO_0042147 (EC: NAS, PMID: 11102511); GO_0070062 (EC: IDA, PMID: 19056867)
has PubMed association: PMID: 8125298; 8619474; 8889548; 9110174; 11062004; 11076863; 11102511; 11112353; 11230166; 11256614; 12477932; 14702039; 15231748; 15247922; 15282546; 15489334; 15489336; 16190980; 16196087; 16335966; 16344560; 16381901; 17101778; 17215244; 17353931; 17620599; 17891154; 17897319; 17916227; 18029348; 18781797; 19056867; 19322201; 19531583; 19553991; 19615732; 19738201; 19874558; 20000738; 20164305; 20301402; 20619655; 20923837; 21139048; 21319273; 21515373; 21733561; 21763482; 21763483; 21822266; 21832049; 21849449; 21875946; 21890473; 21903422; 21906983; 21988832; 22053931; 22154191; 22278960; 22284051; 22336192; 22354992; 22410496; 22513087; 22517097; 22623428; 22673036; 22673115; 22797925; 22801713; 22863883; 22891780; 22939629; 22991136; 23125461; 23261770; 23408866; 23411763; 23452853; 23455922; 23463506; 23536430; 23726718; 24250222
description: vacuolar protein sorting 35 homolog (S. cerevisiae)
database cross reference: HGNC:13487
database cross reference: HPRD:06085
database cross reference: MIM:601501

ENAH
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ENA
alternative term: MENA
alternative term: NDPP1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ENAH
full name from nomenclature authority: enabled homolog (Drosophila)
NCBI GeneID: 55740
NCBI LocusTag: RP11-496N12.7
gene map location: 1q42.12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001725 (EC: IEA); GO_0001843 (EC: IEA); GO_0003779 (EC: IEA); GO_0005515 (EC: IPI, PMID: 16979624); GO_0005737 (EC: IDA); GO_0005829 (EC: TAS); GO_0005886 (EC: IDA); GO_0005925 (EC: IDA); GO_0007411 (EC: TAS); GO_0008154 (EC: IEA); GO_0017124 (EC: IEA); GO_0030027 (EC: IEA); GO_0030054 (EC: IDA); GO_0030175 (EC: IEA); GO_0045202 (EC: IEA); GO_0046907 (EC: IEA); GO_0050699 (EC: IPI, PMID: 17686488); GO_0050852 (EC: TAS)
has PubMed association: PMID: 1420303; 9171351; 9312002; 9407065; 9473484; 10725224; 10747096; 10801818; 10892742; 11696321; 12477932; 12571287; 12672821; 12695497; 12941633; 12967995; 14506234; 14592989; 14702039; 15027125; 15148305; 15469845; 15469846; 15489334; 15556561; 16055720; 16336193; 16494957; 16533770; 16710414; 16964243; 16979624; 17081983; 17101133; 17686488; 18029348; 18158903; 18676769; 18985426; 19081071; 19082477; 19277120; 19322201; 19434313; 19641378; 20083228; 20379614; 21044950; 21139048; 21209853; 21335464; 21398369; 21423205; 21769917; 21890473; 21988832; 22472896; 22615875; 22863883; 23000965; 23062752; 23129656; 23251661; 23602568; 24076656; 24163370
description: enabled homolog (Drosophila)
database cross reference: Ensembl:ENSG00000154380
database cross reference: HGNC:18271
database cross reference: HPRD:12360
database cross reference: MIM:609061
database cross reference: Vega:OTTHUMG00000037742

ADCY10
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HCA2
alternative term: SAC
alternative term: SACI
alternative term: Sacy
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ADCY10
full name from nomenclature authority: adenylate cyclase 10 (soluble)
NCBI GeneID: 55811
NCBI LocusTag: RP1-313L4.2
gene map location: 1q24
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000287 (EC: IEA); GO_0004016 (EC: NAS, PMID: 9874775); GO_0005524 (EC: IEA); GO_0005737 (EC: TAS, PMID: 9874775); GO_0005829 (EC: NAS, PMID: 9874775); GO_0005856 (EC: IEA); GO_0005886 (EC: IEA); GO_0006171 (EC: NAS, PMID: 9874775); GO_0007283 (EC: IEA); GO_0030145 (EC: IEA); GO_0030424 (EC: IEA); GO_0030425 (EC: IEA); GO_0030426 (EC: IEA); GO_0035556 (EC: IEA); GO_0043025 (EC: IEA); GO_0043065 (EC: IEA); GO_0045177 (EC: IEA); GO_0045178 (EC: IEA); GO_0048471 (EC: IEA); GO_0051117 (EC: IEA)
has PubMed association: PMID: 2165385; 7937899; 8663304; 9417641; 9694905; 9874775; 10446129; 10737962; 10915626; 11423534; 11875252; 11932268; 12475901; 12477932; 12609998; 12626323; 12958208; 14993377; 16144836; 16344560; 17591988; 18209474; 19064610; 19093065; 19536175; 20130594; 20379614; 21994938; 22775536; 23255611; 23455922; 24100033
description: adenylate cyclase 10 (soluble)
database cross reference: Ensembl:ENSG00000143199
database cross reference: HGNC:21285
database cross reference: HPRD:05549
database cross reference: MIM:605205
database cross reference: Vega:OTTHUMG00000034573

PSENEN
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MSTP064
alternative term: PEN-2
alternative term: PEN2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PSENEN
full name from nomenclature authority: presenilin enhancer gamma secretase subunit
NCBI GeneID: 55851
NCBI LocusTag: MDS033
gene map location: 19q13.12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 16641999); GO_0005783 (EC: IDA, PMID: 15274632); GO_0005789 (EC: IEA); GO_0005794 (EC: IDA, PMID: 15274632); GO_0005886 (EC: TAS); GO_0005887 (EC: IDA, PMID: 15274632); GO_0006509 (EC: IDA, PMID: 15274632); GO_0007219 (EC: TAS); GO_0007220 (EC: TAS, PMID: 15274632); GO_0016485 (EC: IDA, PMID: 15274632); GO_0031293 (EC: TAS); GO_0032580 (EC: IEA); GO_0042987 (EC: TAS, PMID: 15274632); GO_0043065 (EC: TAS); GO_0043085 (EC: IDA, PMID: 15274632); GO_0048011 (EC: TAS); GO_0097190 (EC: TAS)
has PubMed association: PMID: 12110170; 12198112; 12477932; 12522139; 12639958; 12660785; 12679784; 12740439; 12763021; 12787561; 12843241; 14572442; 15274632; 15322084; 15322109; 15474363; 15489334; 15721744; 15953349; 15975090; 16234243; 16234244; 16331303; 16449647; 16630834; 16641999; 16712791; 17280645; 17668005; 17986144; 19036728; 19889971; 20178366; 20534834; 20847418; 20929727; 21412258; 21454611; 21852538; 21988832; 22479317; 22622421; 22689582; 22787762; 23096707; 23134962; 23246698; 23685131; 24250222
description: presenilin enhancer gamma secretase subunit
database cross reference: HGNC:30100
database cross reference: HPRD:06362
database cross reference: MIM:607632

THSD1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: TMTSP
alternative term: UNQ3010
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: THSD1
full name from nomenclature authority: thrombospondin, type I, domain containing 1
NCBI GeneID: 55901
NCBI LocusTag: RP11-245D16.1
gene map location: 13q14.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 13
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002244 (EC: IEA); GO_0005576 (EC: IEA); GO_0005737 (EC: IDA); GO_0009986 (EC: IEA); GO_0016021 (EC: IEA); GO_0071944 (EC: IEA)
has PubMed association: PMID: 7687569; 12477932; 12975309; 14702039; 15057823; 15371459; 15489334; 17047544; 18029348; 18403638; 22664866
description: thrombospondin, type I, domain containing 1
database cross reference: Ensembl:ENSG00000136114
database cross reference: HGNC:17754
database cross reference: HPRD:18180
database cross reference: Vega:OTTHUMG00000016963

DPYSL5
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CRAM
alternative term: CRMP-5
alternative term: CRMP5
alternative term: Ulip6
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: DPYSL5
full name from nomenclature authority: dihydropyrimidinase-like 5
NCBI GeneID: 56896
gene map location: 2p23.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005829 (EC: TAS); GO_0006208 (EC: IEA); GO_0007165 (EC: TAS, PMID: 10851247); GO_0007399 (EC: TAS, PMID: 10851247); GO_0007411 (EC: TAS); GO_0016812 (EC: IEA); GO_0030425 (EC: IEA); GO_0043025 (EC: IEA)
has PubMed association: PMID: 10851247; 10956643; 11034345; 11220734; 11549731; 12093729; 12134159; 12477932; 12838519; 14702039; 15489334; 16169070; 16344560; 18306241; 18347453; 18769332; 18854154; 18931014; 21139048; 21988832; 22581228; 23251661; 23298946; 23373749; 24324268
description: dihydropyrimidinase-like 5
database cross reference: Ensembl:ENSG00000157851
database cross reference: HGNC:20637
database cross reference: HPRD:10522
database cross reference: MIM:608383
database cross reference: Vega:OTTHUMG00000097071

NCLN
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NET59
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NCLN
full name from nomenclature authority: nicalin
NCBI GeneID: 56926
gene map location: 19p13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 17261586); GO_0005789 (EC: IEA); GO_0008233 (EC: IEA); GO_0009966 (EC: IEA); GO_0016021 (EC: IEA)
has PubMed association: PMID: 11076863; 11230166; 12477932; 14702039; 15057824; 15257293; 15489334; 15489336; 16196087; 16381901; 17261586; 18029348; 21139048; 21890473; 21906983; 21963094; 21987572; 22268729; 22505724; 22939629
description: nicalin
database cross reference: Ensembl:ENSG00000125912
database cross reference: HGNC:26923
database cross reference: HPRD:07126
database cross reference: MIM:609156
database cross reference: Vega:OTTHUMG00000180687

ENTPD7
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: LALP1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ENTPD7
full name from nomenclature authority: ectonucleoside triphosphate diphosphohydrolase 7
NCBI GeneID: 57089
NCBI LocusTag: RP11-483F11.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0016021 (EC: IEA); GO_0016787 (EC: IEA); GO_0030659 (EC: IEA); GO_0046872 (EC: IEA)
has PubMed association: PMID: 11278936; 12477932; 14702039; 15164054; 15489334; 20534741; 22412388
description: ectonucleoside triphosphate diphosphohydrolase 7
database cross reference: HGNC:19745
database cross reference: HPRD:10939

CASS4
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: C20orf32
alternative term: CAS4
alternative term: HEFL
alternative term: HEPL
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CASS4
full name from nomenclature authority: Cas scaffolding protein family member 4
NCBI GeneID: 57091
gene map location: 20q13.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 20
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000155 (EC: IEA); GO_0005737 (EC: IEA); GO_0005856 (EC: IEA); GO_0005925 (EC: IEA); GO_0007155 (EC: IEA); GO_0016020 (EC: IEA)
has PubMed association: PMID: 11780052; 12477932; 14702039; 15489334; 16344560; 18256281; 19380743; 23001926
description: Cas scaffolding protein family member 4
database cross reference: Ensembl:ENSG00000087589
database cross reference: HGNC:15878
database cross reference: HPRD:09842
database cross reference: Vega:OTTHUMG00000032788

NLRC4
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CARD12
alternative term: CLAN
alternative term: CLAN1
alternative term: CLANA
alternative term: CLANB
alternative term: CLANC
alternative term: CLAND
alternative term: CLR2.1
alternative term: IPAF
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NLRC4
full name from nomenclature authority: NLR family, CARD domain containing 4
NCBI GeneID: 58484
NCBI LocusTag: UNQ6189/PRO20215
gene map location: 2p22-p21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000287 (EC: TAS, PMID: 15882992); GO_0002218 (EC: ISS); GO_0005515 (EC: IPI, PMID: 11374873); GO_0005524 (EC: IDA, PMID: 15882992); GO_0005622 (EC: NAS, PMID: 15107016); GO_0005829 (EC: ISS); GO_0005829 (EC: TAS); GO_0006919 (EC: IDA, PMID: 15030775); GO_0006954 (EC: ISS); GO_0016045 (EC: IDA, PMID: 15107016); GO_0035872 (EC: TAS); GO_0042742 (EC: IDA, PMID: 15107016); GO_0042802 (EC: IPI, PMID: 11374873); GO_0042803 (EC: IDA, PMID: 15107016); GO_0043065 (EC: IDA, PMID: 12646168); GO_0045087 (EC: TAS); GO_0050702 (EC: IDA, PMID: 15882992); GO_0051092 (EC: IDA, PMID: 12646168); GO_0051260 (EC: ISS); GO_0070269 (EC: ISS); GO_0072557 (EC: ISS)
has PubMed association: PMID: 11374873; 11390368; 11472070; 12477932; 12545166; 12646168; 12975309; 14702039; 15030775; 15107016; 15174051; 15489334; 15528373; 15580302; 15882992; 16817903; 17418785; 17620097; 18453601; 20085538; 20349122; 21918512; 22227487; 22547706; 23012363; 23215645
description: NLR family, CARD domain containing 4
database cross reference: Ensembl:ENSG00000091106
database cross reference: HGNC:16412
database cross reference: HPRD:06014
database cross reference: MIM:606831
database cross reference: Vega:OTTHUMG00000152107

NOD2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: ACUG
alternative term: BLAU
alternative term: CARD15
alternative term: CD
alternative term: CLR16.3
alternative term: IBD1
alternative term: NLRC2
alternative term: NOD2B
alternative term: PSORAS1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NOD2
full name from nomenclature authority: nucleotide-binding oligomerization domain containing 2
NCBI GeneID: 64127
gene map location: 16q21
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000187 (EC: TAS); GO_0002224 (EC: TAS); GO_0002227 (EC: IEA); GO_0002282 (EC: IEA); GO_0002367 (EC: IMP, PMID: 16260731); GO_0002381 (EC: IEA); GO_0002606 (EC: ISS); GO_0002710 (EC: IEA); GO_0002732 (EC: IEA); GO_0002755 (EC: TAS); GO_0002756 (EC: TAS); GO_0002830 (EC: IMP); GO_0002862 (EC: IEA); GO_0002925 (EC: IEA); GO_0005515 (EC: IPI, PMID: 11472070); GO_0005524 (EC: IEA); GO_0005737 (EC: IDA); GO_0005737 (EC: TAS, PMID: 15967716); GO_0005829 (EC: IDA, PMID: 15998797); GO_0005829 (EC: TAS); GO_0005856 (EC: IDA); GO_0005886 (EC: IDA, PMID: 15998797); GO_0006952 (EC: TAS, PMID: 15967716); GO_0006965 (EC: IEA); GO_0007254 (EC: TAS); GO_0007584 (EC: IEA); GO_0008180 (EC: IDA, Qualifier: colocalizes_with, PMID: 17337451); GO_0009595 (EC: TAS, PMID: 15967716); GO_0009986 (EC: IDA, PMID: 16714539); GO_0016045 (EC: IDA, PMID: 15653568); GO_0019899 (EC: IPI, PMID: 15753091); GO_0019901 (EC: IPI, PMID: 15075345); GO_0030277 (EC: IMP, PMID: 17058067); GO_0031982 (EC: IDA, PMID: 15998797); GO_0032088 (EC: IEA); GO_0032495 (EC: IDA, PMID: 15998797); GO_0032496 (EC: IEA); GO_0032498 (EC: IDA, PMID: 12527755); GO_0032500 (EC: IDA, PMID: 15998797); GO_0032689 (EC: IEA); GO_0032695 (EC: IEA); GO_0032701 (EC: IEA); GO_0032703 (EC: IEA); GO_0032720 (EC: IEA); GO_0032731 (EC: IMP); GO_0032733 (EC: ISS); GO_0032735 (EC: IEA); GO_0032740 (EC: IMP, PMID: 17919942); GO_0032755 (EC: IDA, PMID: 16414084); GO_0032760 (EC: IDA, PMID: 17187069); GO_0032760 (EC: IMP); GO_0032874 (EC: IDA, PMID: 17187069); GO_0034134 (EC: TAS); GO_0034136 (EC: IEA); GO_0034138 (EC: TAS); GO_0034142 (EC: TAS); GO_0034146 (EC: TAS); GO_0034162 (EC: TAS); GO_0034166 (EC: TAS); GO_0035419 (EC: ISS); GO_0035556 (EC: IDA, PMID: 15653568); GO_0035666 (EC: TAS); GO_0035872 (EC: TAS); GO_0038123 (EC: TAS); GO_0038124 (EC: TAS); GO_0042742 (EC: IDA, PMID: 15653568); GO_0042834 (EC: IDA, PMID: 15998797); GO_0043123 (EC: IDA, PMID: 11087742); GO_0043234 (EC: IDA); GO_0043330 (EC: IEA); GO_0043552 (EC: ISS); GO_004413…
has PubMed association: PMID: 7809109; 8587604; 8894707; 9541106; 9797359; 9924607; 10053016; 10439963; 11087742; 11318544; 11385576; 11385577; 11425413; 11472070; 11528384; 11752413; 11834373; 11837220; 11875755; 11890351; 11910336; 11910337; 11938034; 11976792; 12019209; 12019468; 12020527; 12105836; 12105838; 12115195; 12115249; 12198692; 12202985; 12210321; 12360101; 12397216; 12415614; 12454871; 12459523; 12474146; 12492195; 12508397; 12512038; 12512064; 12514169; 12527755; 12529700; 12532667; 12556233; 12563685; 12577202; 12595627; 12595906; 12617879; 12618963; 12626759; 12631666; 12631668; 12631669; 12649405; 12650796; 12671896; 12671897; 12673278; 12704363; 12810925; 12823148; 12851870; 12871942; 12876263; 12879366; 12923865; 12930309; 12940436; 13680285; 14508222; 14516815; 14522785; 14555911; 14597055; 14627676; 14638352; 14644139; 14690304; 14743885; 14747834; 14750643; 14971813; 14996717; 15002819; 15008984; 15016407; 15024686; 15044951; 15046221; 15046222; 15052696; 15056084; 15075345; 15090455; 15095853; 15107016; 15107849; 15140210; 15142196; 15145460; 15168811; 15180737; 15190267; 15194649; 15202784; 15214053; 15276183; 15279649; 15289769; 15308523; 15320482; 15367194; 15377357; 15459013; 15468360; 15472511; 15479689; 15489579; 15492242; 15515785; 15516360; 15520108; 15527324; 15539411; 15539413; 15551253; 15571586; 15571588; 15578724; 15620648; 15626887; 15626888; 15637755; 15638227; 15643611; 15653568; 15654786; 15655821; 15666202; 15667501; 15685536; 15712650; 15753091; 15770725; 15778542; 15785318; 15795594; 15800781; 15803022; 15807862; 15812565; 15840263; 15842589; 15843082; 15927452; 15930978; 15967635; 15967716; 15973116; 15973118; 15984988; 15990626; 15998797; 16000642; 16002353; 16008671; 16009674; 16010583; 16080653; 16115863; 16126943; 16133971; 16134725; 16134731; 16148063; 16161956; 16167972; 16174099; 16179784; 16198136; 16203728; 16230083; 16239840; 16239841; 16244543; 16255050; 16257953; 16260731; 16266221; 16267612; 16278823; 16279904; 16306764; 16315780; …
description: nucleotide-binding oligomerization domain containing 2
database cross reference: Ensembl:ENSG00000167207
database cross reference: HGNC:5331
database cross reference: HPRD:05810
database cross reference: MIM:605956
database cross reference: Vega:OTTHUMG00000133171

ATG3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APG3
alternative term: APG3-LIKE
alternative term: APG3L
alternative term: PC3-96
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ATG3
full name from nomenclature authority: autophagy related 3
NCBI GeneID: 64422
gene map location: 3q13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000045 (EC: ISS); GO_0000153 (EC: IPI, PMID: 11825910); GO_0005515 (EC: IPI, PMID: 11825910); GO_0005829 (EC: IDA, PMID: 11825910); GO_0006464 (EC: IDA, PMID: 11825910); GO_0006612 (EC: ISS); GO_0016567 (EC: IDA, PMID: 11825910); GO_0019776 (EC: ISS); GO_0019777 (EC: ISS); GO_0019787 (EC: IDA, PMID: 11825910); GO_0019899 (EC: IPI, PMID: 11825910); GO_0043653 (EC: ISS); GO_1902017 (EC: ISS)
has PubMed association: PMID: 11825910; 12477932; 14702039; 15144186; 15355958; 15489334; 15592455; 16303767; 16704426; 17353931; 19342671; 19838173; 19932681; 20061800; 20562859; 20697744; 20723759; 21139048; 21906983; 22053931; 22505724; 22644571; 22863883; 23119048; 23824909; 23829686; 24191030
description: autophagy related 3
database cross reference: Ensembl:ENSG00000144848
database cross reference: HGNC:20962
database cross reference: HPRD:10654
database cross reference: MIM:609606
database cross reference: Vega:OTTHUMG00000159260

PORCN
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DHOF
alternative term: FODH
alternative term: MG61
alternative term: PORC
alternative term: PPN
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PORCN
full name from nomenclature authority: porcupine homolog (Drosophila)
NCBI GeneID: 64840
gene map location: Xp11.23
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: X
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0009100 (EC: IEA); GO_0016055 (EC: IEA); GO_0016746 (EC: IEA); GO_0030176 (EC: IEA); GO_0032281 (EC: IEA)
has PubMed association: PMID: 10866835; 12034504; 12477932; 14702039; 15146197; 15489334; 17546030; 17546031; 18193088; 18325042; 19277062; 19309688; 19586929; 19681149; 19863546; 20198348; 20301712; 20854095; 21472892; 22509316; 22735390; 22888000; 22923569; 23131169; 23188502; 23399492; 23547709; 23696273
description: porcupine homolog (Drosophila)
database cross reference: Ensembl:ENSG00000102312
database cross reference: HGNC:17652
database cross reference: HPRD:06680
database cross reference: MIM:300651
database cross reference: Vega:OTTHUMG00000024116

KREMEN2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: KRM2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: KREMEN2
full name from nomenclature authority: kringle containing transmembrane protein 2
NCBI GeneID: 79412
gene map location: 16p13.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0016021 (EC: IEA); GO_0016055 (EC: IEA)
has PubMed association: PMID: 8125298; 12050670; 12477932; 14702039; 15489334; 16303743; 20846389; 21139048
description: kringle containing transmembrane protein 2
database cross reference: Ensembl:ENSG00000131650
database cross reference: HGNC:18797
database cross reference: HPRD:13933
database cross reference: MIM:609899
database cross reference: Vega:OTTHUMG00000128976

APH1B
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APH-1B
alternative term: PRO1328
alternative term: PSFL
alternative term: TAAV688
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: APH1B
full name from nomenclature authority: APH1B gamma secretase subunit
NCBI GeneID: 83464
NCBI LocusTag: UNQ688/PRO1328
gene map location: 15q22.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 12297508); GO_0005886 (EC: TAS); GO_0007219 (EC: TAS); GO_0007220 (EC: TAS); GO_0008233 (EC: IDA, PMID: 12297508); GO_0016021 (EC: IDA, PMID: 12297508); GO_0016485 (EC: IDA, PMID: 12297508); GO_0030133 (EC: IDA); GO_0031293 (EC: TAS); GO_0043065 (EC: TAS); GO_0043085 (EC: IEA); GO_0048011 (EC: TAS); GO_0097190 (EC: TAS)
has PubMed association: PMID: 11076863; 11230166; 11256614; 12110170; 12297508; 12471034; 12477932; 12740439; 12763021; 12787561; 12843241; 12857757; 12975309; 14702039; 15286082; 15474363; 15489334; 15489336; 15591316; 15629423; 15721744; 15823552; 16344560; 16381901; 16630834; 16757808; 17466415; 17986144; 18987747; 19774691; 21890473; 21906983; 21963094
description: APH1B gamma secretase subunit
database cross reference: Ensembl:ENSG00000138613
database cross reference: HGNC:24080
database cross reference: HPRD:06361
database cross reference: MIM:607630
database cross reference: Vega:OTTHUMG00000132863

ATG10
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: APG10
alternative term: APG10L
alternative term: pp12616
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ATG10
full name from nomenclature authority: autophagy related 10
NCBI GeneID: 83734
NCBI LocusTag: PP12616
gene map location: 5q14.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 5
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005622 (EC: IDA); GO_0005737 (EC: IEA); GO_0006497 (EC: ISS); GO_0006914 (EC: IMP, PMID: 15657430); GO_0015031 (EC: IEA); GO_0019777 (EC: ISS); GO_0031401 (EC: ISS); GO_0032446 (EC: IDA, PMID: 16963840); GO_0034263 (EC: IMP, PMID: 17256008)
has PubMed association: PMID: 2890687; 8125298; 11076863; 11230166; 11256614; 12477932; 12482611; 12890687; 14702039; 15489334; 15489336; 15498874; 15657430; 16381901; 16963840; 17256008; 17353931; 20379614; 20562859; 23285162; 23850577; 24250222
description: autophagy related 10
database cross reference: Ensembl:ENSG00000152348
database cross reference: HGNC:20315
database cross reference: HPRD:16497
database cross reference: MIM:610800
database cross reference: Vega:OTTHUMG00000119041

EIF2A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: EIF-2A
alternative term: MST089
alternative term: MSTP004
alternative term: MSTP089
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: EIF2A
full name from nomenclature authority: eukaryotic translation initiation factor 2A, 65kDa
NCBI GeneID: 83939
NCBI LocusTag: CDA02
gene map location: 3q25.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000049 (EC: IMP, PMID: 12133843); GO_0003743 (EC: IMP, PMID: 12133843); GO_0005515 (EC: IPI, PMID: 18816594); GO_0005615 (EC: IDA); GO_0005737 (EC: IDA, PMID: 12133843); GO_0005850 (EC: IDA, PMID: 12133843); GO_0006417 (EC: IMP, PMID: 12133843); GO_0006468 (EC: IEA); GO_0009967 (EC: IEA); GO_0032933 (EC: IEA); GO_0042255 (EC: IMP, PMID: 12133843); GO_0043022 (EC: IMP, PMID: 12133843); GO_0072562 (EC: IDA)
has PubMed association: PMID: 1620067; 12133843; 12370288; 12477932; 12687390; 14702039; 15341733; 15345721; 15475356; 15718232; 15781241; 15961545; 16373505; 16631606; 16717090; 16870703; 16928686; 17274640; 17407708; 17553788; 17715234; 17894550; 18063576; 18195013; 18274552; 18287093; 18337511; 18794359; 18816594; 19131336; 19190324; 19223463; 19229320; 19586904; 19605483; 19744687; 19913121; 20376341; 20434207; 20519500; 20628086; 20706999; 21085474; 21090173; 21139048; 21203563; 21622569; 21730287; 21832049; 21906983; 21963094; 22355666; 22505724; 22863883; 22915583; 22939629; 22948139; 23000965; 23046979; 23471998; 23690448
description: eukaryotic translation initiation factor 2A, 65kDa
database cross reference: Ensembl:ENSG00000144895
database cross reference: HGNC:3254
database cross reference: HPRD:11739
database cross reference: MIM:609234
database cross reference: Vega:OTTHUMG00000159775

KAT8
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MOF
alternative term: MYST1
alternative term: ZC2HC8
alternative term: hMOF
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: KAT8
full name from nomenclature authority: K(lysine) acetyltransferase 8
NCBI GeneID: 84148
NCBI LocusTag: PP7073
gene map location: 16p11.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000123 (EC: IDA); GO_0000776 (EC: IEA); GO_0004402 (EC: IDA, PMID: 11742995); GO_0005515 (EC: IPI, PMID: 11965546); GO_0005634 (EC: IDA, PMID: 11742995); GO_0005654 (EC: TAS); GO_0006325 (EC: TAS); GO_0006351 (EC: IEA); GO_0008134 (EC: IDA, PMID: 11742995); GO_0016407 (EC: IDA, PMID: 11742995); GO_0016573 (EC: IDA, PMID: 11742995); GO_0019899 (EC: IEA); GO_0030099 (EC: IDA, PMID: 11742995); GO_0031965 (EC: IDA); GO_0035064 (EC: IDA, PMID: 15960975); GO_0043981 (EC: IDA); GO_0043982 (EC: IDA); GO_0043984 (EC: IDA); GO_0043984 (EC: IMP, PMID: 15960975); GO_0043995 (EC: IDA, Qualifier: contributes_to); GO_0043996 (EC: IDA, Qualifier: contributes_to); GO_0045892 (EC: IDA, PMID: 11742995); GO_0045893 (EC: IDA, PMID: 11742995); GO_0045893 (EC: IMP, PMID: 15960975); GO_0046872 (EC: IEA); GO_0046972 (EC: IDA, Qualifier: contributes_to); GO_0071339 (EC: IDA, PMID: 15960975); GO_0072487 (EC: IDA)
has PubMed association: PMID: 8125298; 10786633; 11742995; 11965546; 12397079; 12477932; 14702039; 15342556; 15489334; 15498874; 15923642; 15960975; 16024812; 16096645; 16227571; 17182677; 17189187; 17694080; 17967868; 18058815; 19578370; 19766566; 19854137; 19913121; 20018852; 20224553; 20360068; 20479123; 20628086; 21217699; 21321083; 21502975; 21691301; 22020126; 22152480; 22586264; 22918831; 22939629; 23602568; 23628702; 23638218; 23863932; 24126058; 24163370
description: K(lysine) acetyltransferase 8
database cross reference: Ensembl:ENSG00000103510
database cross reference: HGNC:17933
database cross reference: HPRD:11381
database cross reference: MIM:609912
database cross reference: Vega:OTTHUMG00000132410

AKT1S1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: Lobe
alternative term: PRAS40
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: AKT1S1
full name from nomenclature authority: AKT1 substrate 1 (proline-rich)
NCBI GeneID: 84335
gene map location: 19q13.33
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 12524439); GO_0005634 (EC: IEA); GO_0005737 (EC: IDA); GO_0005829 (EC: ISS); GO_0005829 (EC: TAS); GO_0006469 (EC: IDA, PMID: 17386266); GO_0007173 (EC: TAS); GO_0008543 (EC: TAS); GO_0031931 (EC: IDA, Qualifier: colocalizes_with, PMID: 17386266); GO_0032007 (EC: IDA, PMID: 17386266); GO_0038095 (EC: TAS); GO_0043523 (EC: ISS); GO_0045087 (EC: TAS); GO_0045792 (EC: IDA, PMID: 17386266); GO_0048011 (EC: TAS); GO_0048015 (EC: TAS)
has PubMed association: PMID: 8125298; 12477932; 12524439; 14702039; 14973226; 15161933; 15302935; 15324660; 15489334; 16169070; 16174443; 16344560; 17081983; 17277771; 17386266; 17510057; 17604271; 18215133; 18372248; 19446321; 20169205; 21886838; 21900206; 21906675; 21910584; 21914810; 21981924; 22090422; 22241085; 22354785; 22863883; 22873724; 23444366; 23460019; 23712034; 24255178
description: AKT1 substrate 1 (proline-rich)
database cross reference: Ensembl:ENSG00000204673
database cross reference: HGNC:28426
database cross reference: HPRD:12441
database cross reference: MIM:610221
database cross reference: Vega:OTTHUMG00000150246

DCTN5
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: DCTN5
full name from nomenclature authority: dynactin 5 (p25)
NCBI GeneID: 84516
gene map location: 16p12.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 16
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000777 (EC: IEA); GO_0005813 (EC: IDA); GO_0005829 (EC: TAS); GO_0019886 (EC: TAS)
has PubMed association: PMID: 10525537; 12477932; 14702039; 15043994; 15489334; 16189514; 16344560; 17554300; 20360068; 20508983; 21139048; 21890473; 21906983; 22505724
description: dynactin 5 (p25)

PGBD1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HUCEP-4
alternative term: SCAND4
alternative term: dJ874C20.4
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: PGBD1
full name from nomenclature authority: piggyBac transposable element derived 1
NCBI GeneID: 84547
NCBI LocusTag: hucep-4
gene map location: 6p22.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0003700 (EC: IEA); GO_0005044 (EC: IEA); GO_0005634 (EC: IEA); GO_0016020 (EC: IEA)
has PubMed association: PMID: 8125298; 8889548; 12477932; 12955498; 16344560; 18029348; 18830724; 20534741; 20673877; 20873219; 22037552; 22488895
description: piggyBac transposable element derived 1
database cross reference: Ensembl:ENSG00000137338
database cross reference: HGNC:19398
database cross reference: HPRD:11426
database cross reference: Vega:OTTHUMG00000014520

ORAI1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CRACM1
alternative term: IMD9
alternative term: ORAT1
alternative term: TMEM142A
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ORAI1
full name from nomenclature authority: ORAI calcium release-activated calcium modulator 1
NCBI GeneID: 84876
gene map location: 12q24.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 12
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002115 (EC: IEA); GO_0002376 (EC: IEA); GO_0005515 (EC: IPI, PMID: 17905723); GO_0005887 (EC: IDA, PMID: 16645049); GO_0007596 (EC: TAS); GO_0015279 (EC: IDA, PMID: 16645049); GO_0043234 (EC: IEA); GO_0051924 (EC: IMP, PMID: 16921383); GO_0051928 (EC: IDA, PMID: 16645049)
has PubMed association: PMID: 12477932; 14702039; 15489334; 16147976; 16341674; 16582901; 16645049; 16733527; 16766533; 16807233; 16921383; 16978865; 17045966; 17218358; 17224452; 17360584; 17400243; 17442569; 17452328; 17684017; 17702753; 17905723; 17968026; 17991693; 18006576; 18096706; 18187424; 18190941; 18239188; 18250319; 18326500; 18400989; 18403424; 18420579; 18436303; 18448669; 18506892; 18542992; 18569867; 18644792; 18768920; 18832420; 18843204; 18845811; 18995841; 19075015; 19088073; 19171672; 19182790; 19185847; 19189966; 19228695; 19249086; 19260825; 19289460; 19366689; 19403622; 19429662; 19433061; 19447651; 19487696; 19506081; 19622747; 19675303; 19706554; 19754898; 19843011; 19887627; 19965684; 20004786; 20007711; 20018736; 20037597; 20073506; 20194530; 20194792; 20354224; 20395295; 20534587; 20587595; 20607548; 20887894; 20961852; 21224390; 21239714; 21266088; 21300876; 21321120; 21364678; 21383014; 21408196; 21420116; 21441136; 21487896; 21640715; 21670147; 21674042; 21782006; 21790973; 21847095; 21865174; 21873556; 21945734; 21956116; 21987804; 22031597; 22110130; 22144678; 22253717; 22278058; 22298778; 22381755; 22384096; 22387225; 22389502; 22494970; 22495877; 22546867; 22549787; 22556336; 22586105; 22640869; 22641696; 22681560; 22778704; 23043102; 23049826; 23115638; 23184982; 23203806; 23212906; 23307288; 23447534; 23455504; 23512987; 23512989; 23515871; 23685155; 23700407; 23703676; 23774210; 23800047; 23816623; 23890116; 23890117; 23943619; 24056904; 24321771
description: ORAI calcium release-activated calcium modulator 1
database cross reference: HGNC:25896
database cross reference: HPRD:08599
database cross reference: MIM:610277

WNT3A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: WNT3A
full name from nomenclature authority: wingless-type MMTV integration site family, member 3A
NCBI GeneID: 89780
gene map location: 1q42
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001649 (EC: IEA); GO_0001701 (EC: IEA); GO_0001934 (EC: IDA); GO_0001947 (EC: IEA); GO_0002092 (EC: IDA, PMID: 16890161); GO_0003136 (EC: IDA, PMID: 19736317); GO_0003713 (EC: ISS); GO_0005109 (EC: IBA); GO_0005110 (EC: IEA); GO_0005515 (EC: IPI, PMID: 19072540); GO_0005576 (EC: TAS); GO_0005578 (EC: IEA); GO_0005615 (EC: IBA); GO_0005615 (EC: ISS); GO_0005788 (EC: TAS); GO_0005796 (EC: TAS); GO_0005886 (EC: TAS); GO_0007411 (EC: IEA); GO_0008284 (EC: ISS); GO_0009986 (EC: ISS); GO_0010387 (EC: ISS); GO_0010977 (EC: ISS); GO_0019904 (EC: IEA); GO_0021527 (EC: IEA); GO_0021766 (EC: IEA); GO_0021846 (EC: ISS); GO_0021874 (EC: IEA); GO_0021904 (EC: IEA); GO_0030097 (EC: IEA); GO_0030182 (EC: IBA); GO_0030182 (EC: ISS); GO_0030198 (EC: IEA); GO_0030879 (EC: IEA); GO_0030890 (EC: IEA); GO_0032092 (EC: IDA, PMID: 16890161); GO_0033138 (EC: IDA); GO_0034613 (EC: IEA); GO_0035413 (EC: IDA); GO_0035914 (EC: IEA); GO_0036342 (EC: IEA); GO_0042472 (EC: IEA); GO_0043280 (EC: IEA); GO_0045599 (EC: IEA); GO_0045893 (EC: ISS); GO_0045944 (EC: IDA); GO_0048018 (EC: IDA); GO_0048337 (EC: IDA); GO_0048343 (EC: IEA); GO_0048697 (EC: IEA); GO_0048843 (EC: IEA); GO_0050768 (EC: ISS); GO_0051091 (EC: IEA); GO_0060021 (EC: IMP, PMID: 18413325); GO_0060070 (EC: IDA, PMID: 19101069); GO_0061098 (EC: IEA); GO_0061184 (EC: IDA, PMID: 10654605); GO_0061317 (EC: IDA); GO_0070507 (EC: IEA); GO_0070527 (EC: IEA); GO_0071300 (EC: ISS); GO_0090245 (EC: IEA); GO_0090263 (EC: IDA, PMID: 17976063); GO_2000049 (EC: IEA); GO_2000081 (EC: IEA); GO_2000727 (EC: IDA)
has PubMed association: PMID: 8167409; 8168088; 10557084; 10654605; 10866835; 11414706; 11788904; 11836627; 12052822; 12067714; 12477932; 12556519; 12629517; 12805222; 12897152; 14702039; 14722104; 14739301; 15454084; 15489334; 16227623; 16344560; 16565323; 16621789; 16710414; 16799642; 16890161; 17137849; 17211448; 17458904; 17544413; 17546602; 17595165; 17698587; 17822920; 17888180; 17976063; 17990294; 18242164; 18305214; 18344425; 18413325; 18462958; 18505824; 18555765; 18615587; 18632632; 18719101; 18724388; 18941195; 19072540; 19101069; 19144919; 19265664; 19351711; 19453261; 19523451; 19736317; 19816934; 19881541; 19887570; 19901330; 19910923; 20085589; 20093360; 20227366; 20336604; 20347274; 20634891; 20693288; 20723538; 20735988; 20932509; 21123170; 21422228; 21536751; 21600099; 21606194; 21667018; 21670201; 21957254; 22005028; 22110662; 22396540; 22550094; 22705156; 22714865; 22789636; 22824791; 22876125; 22941468; 23168335; 23204070; 23268410; 23276938; 23337036; 23382209; 23396967; 23396968; 23509994; 23559372; 23893409; 23954131; 23999248; 24321072
description: wingless-type MMTV integration site family, member 3A

CHRFAM7A
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CHRNA7
alternative term: CHRNA7-DR1
alternative term: D-10
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CHRFAM7A
full name from nomenclature authority: CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
NCBI GeneID: 89832
gene map location: 15q13.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 15
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005230 (EC: IEA); GO_0016021 (EC: IEA)
has PubMed association: PMID: 9782083; 11424985; 11829490; 12477932; 14729617; 15489334; 15885267; 16417613; 16572171; 16823804; 17012698; 17192894; 19082523; 19149910; 19462340; 19631623; 19641318; 20351714; 20926142; 22300029; 23553139; 24024466
description: CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
database cross reference: Ensembl:ENSG00000166664
database cross reference: HGNC:15781
database cross reference: HPRD:18704
database cross reference: MIM:609756
database cross reference: Vega:OTTHUMG00000175645

EXOC3L2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: XTP7
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: EXOC3L2
full name from nomenclature authority: exocyst complex component 3-like 2
NCBI GeneID: 90332
gene map location: 19q13.32
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000145 (EC: IEA); GO_0003674 (EC: ND); GO_0005575 (EC: ND); GO_0006887 (EC: IEA); GO_0008150 (EC: ND)
has PubMed association: PMID: 8125298; 8889549; 12477932; 14702039; 19197348; 20460622; 21566143; 22139419; 22381399
description: exocyst complex component 3-like 2
database cross reference: Ensembl:ENSG00000130201
database cross reference: HGNC:30162
database cross reference: HPRD:10311
database cross reference: Vega:OTTHUMG00000155018

IL33
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: C9orf26
alternative term: DVS27
alternative term: IL1F11
alternative term: NF-HEV
alternative term: NFEHEV
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: IL33
full name from nomenclature authority: interleukin 33
NCBI GeneID: 90865
NCBI LocusTag: RP11-575C20.2
gene map location: 9p24.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 9
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002686 (EC: IEA); GO_0002826 (EC: IEA); GO_0002830 (EC: IEA); GO_0005125 (EC: IDA, PMID: 19841166); GO_0005515 (EC: IPI, PMID: 16286016); GO_0005615 (EC: IEA); GO_0005634 (EC: IEA); GO_0005694 (EC: IEA); GO_0006351 (EC: IEA); GO_0030133 (EC: IEA); GO_0032689 (EC: IEA); GO_0032736 (EC: IEA); GO_0032753 (EC: IEA); GO_0032754 (EC: IEA); GO_0032755 (EC: IEA); GO_0043032 (EC: IDA, PMID: 19841166); GO_0045944 (EC: ISS, PMID: 19841166); GO_0050729 (EC: ISS, PMID: 19841166); GO_0051024 (EC: IEA); GO_0051025 (EC: IEA); GO_0090197 (EC: IDA, PMID: 19841166)
has PubMed association: PMID: 10566975; 12477932; 12819012; 15164053; 15489334; 16169070; 16286016; 17185418; 17623648; 17675461; 17700564; 17853410; 18250453; 18539196; 18688256; 18762778; 18787100; 18802081; 18827826; 18836528; 18941187; 18955562; 19037964; 19198610; 19204726; 19248109; 19266498; 19372185; 19393621; 19439663; 19465481; 19508382; 19559631; 19596270; 19756962; 19801525; 19841166; 19860791; 19888696; 19906013; 19913053; 19918048; 20029461; 20035719; 20072851; 20153038; 20305685; 20338108; 20379614; 20385815; 20405148; 20406635; 20532808; 20534741; 20682660; 20689058; 20708824; 20731692; 20816195; 20860503; 20926795; 20931364; 20958987; 20963466; 21037074; 21190867; 21246230; 21357533; 21431944; 21441054; 21454686; 21519352; 21674220; 21674479; 21682736; 21684348; 21734074; 21737781; 21765905; 21802127; 21804549; 21898270; 21935266; 21949719; 22079334; 22100205; 22189043; 22215666; 22233535; 22239947; 22246057; 22270365; 22304300; 22307629; 22315510; 22329990; 22349136; 22540331; 22587998; 22590860; 22627366; 22634619; 22673732; 22682001; 22699663; 22708120; 22785132; 22809957; 22819319; 22828942; 22836779; 22841163; 22858587; 22921786; 23000728; 23028054; 23039129; 23093619; 23159404; 23162017; 23178147; 23205532; 23206447; 23219168; 23261461; 23300625; 23319592; 23357301; 23362867; 23363980; 23433789; 23464866; 23472165; 23484079; 23485578; 23488689; 23521712; 23525523; 23585867; 23634226; 23641786; 23656573; 23725175; 23759184; 23764374; 23775566; 23805875; 23817569; 23855553; 23935505; 23936781; 23980170; 23999434; 24075188; 24106520; 24107076; 24116703; 24257755; 24323357; 24459820
description: interleukin 33
database cross reference: Ensembl:ENSG00000137033
database cross reference: HGNC:16028
database cross reference: HPRD:12275
database cross reference: MIM:608678
database cross reference: Vega:OTTHUMG00000019516

NLRP3
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: AGTAVPRL
alternative term: AII
alternative term: AVP
alternative term: C1orf7
alternative term: CIAS1
alternative term: CLR1.1
alternative term: FCAS
alternative term: FCU
alternative term: MWS
alternative term: NALP3
alternative term: PYPAF1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: NLRP3
full name from nomenclature authority: NLR family, pyrin domain containing 3
NCBI GeneID: 114548
gene map location: 1q44
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0002674 (EC: IMP, PMID: 11687797); GO_0005515 (EC: IPI, PMID: 11786556); GO_0005524 (EC: IEA); GO_0005737 (EC: IDA, PMID: 17164409); GO_0005737 (EC: TAS, PMID: 15967716); GO_0005829 (EC: TAS); GO_0006915 (EC: NAS, PMID: 12032915); GO_0006919 (EC: IEA); GO_0006952 (EC: TAS, PMID: 15967716); GO_0006954 (EC: IMP, PMID: 12093792); GO_0007165 (EC: NAS, PMID: 11786556); GO_0009595 (EC: TAS, PMID: 15967716); GO_0032088 (EC: IDA, PMID: 14662828); GO_0032611 (EC: IEA); GO_0032621 (EC: IEA); GO_0035872 (EC: TAS); GO_0042347 (EC: IDA, PMID: 14662828); GO_0042834 (EC: TAS, PMID: 15967716); GO_0043280 (EC: IDA, PMID: 15030775); GO_0044546 (EC: IEA); GO_0045087 (EC: TAS); GO_0050701 (EC: IEA); GO_0050713 (EC: IMP, PMID: 12483741); GO_0050718 (EC: IDA, PMID: 15030775); GO_0050728 (EC: IMP, PMID: 12483741); GO_0051092 (EC: IDA, PMID: 19158675); GO_0051259 (EC: TAS, PMID: 15967716); GO_0051607 (EC: IEA); GO_0071222 (EC: IMP, PMID: 12483741); GO_0072559 (EC: IDA, PMID: 15030775)
has PubMed association: PMID: 9653160; 10741953; 11042152; 11687797; 11786556; 11967258; 11992256; 12032915; 12093792; 12355493; 12477932; 12483741; 12522564; 12563287; 12615073; 12673085; 12766759; 14630794; 14662828; 15020601; 15030775; 15071491; 15107016; 15334500; 15593220; 15967716; 16037825; 16234278; 16344560; 16531551; 16642435; 16710414; 16868559; 17046979; 17164343; 17164409; 17178985; 17213252; 17284928; 17393462; 17435760; 17592301; 17599094; 17620097; 17697637; 17763411; 17907925; 18005730; 18063752; 18080732; 18084703; 18174231; 18175851; 18189199; 18263599; 18311798; 18576390; 18719602; 18772453; 19001869; 19058789; 19098911; 19120479; 19120481; 19158675; 19201894; 19223160; 19254587; 19319132; 19337385; 19364881; 19414800; 19454352; 19570822; 19579027; 19648107; 19767079; 19784369; 19805629; 19811501; 19824913; 19826485; 19890791; 19913121; 20002790; 20008285; 20011700; 20031576; 20038581; 20060594; 20131254; 20131270; 20135584; 20148899; 20179743; 20182451; 20237496; 20368800; 20370570; 20384614; 20401456; 20401526; 20403135; 20407038; 20421639; 20502346; 20506209; 20628086; 20668705; 20688930; 20800603; 20808838; 20884650; 20962258; 20980503; 21035374; 21051542; 21058222; 21109514; 21124315; 21124859; 21217695; 21241317; 21245836; 21300955; 21315400; 21342182; 21394384; 21421008; 21451572; 21508263; 21550598; 21560198; 21566220; 21621776; 21637346; 21646297; 21876553; 21880711; 21930705; 21940629; 21940680; 21971358; 21978001; 21994456; 22102247; 22112657; 22128899; 22146561; 22227418; 22227487; 22276187; 22295065; 22325453; 22403613; 22461501; 22490866; 22497426; 22503597; 22522430; 22524199; 22529966; 22541070; 22558425; 22608495; 22698681; 22723549; 22768094; 22796220; 22843550; 22904305; 22933232; 22933241; 22935299; 22948162; 22981536; 22984081; 22984082; 22997256; 23015306; 23066025; 23086037; 23110140; 23171454; 23206693; 23209696; 23211828; 23221073; 23254930; 23264657; 23271661; 23280543; 23315075; 23375846; 23382313; 23399110; 23427152; 23430110; 23434541; 23440…
description: NLR family, pyrin domain containing 3
database cross reference: Ensembl:ENSG00000162711
database cross reference: HGNC:16400
database cross reference: HPRD:05915
database cross reference: MIM:606416
database cross reference: Vega:OTTHUMG00000040647

SORCS1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: hSorCS
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SORCS1
full name from nomenclature authority: sortilin-related VPS10 domain containing receptor 1
NCBI GeneID: 114815
NCBI LocusTag: RP11-446H13.1
gene map location: 10q23-q25
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005515 (EC: IPI, PMID: 12482870); GO_0007218 (EC: NAS, PMID: 11499680); GO_0008188 (EC: NAS, PMID: 11499680); GO_0016020 (EC: IDA, PMID: 12482870); GO_0016021 (EC: IEA)
has PubMed association: PMID: 11499680; 12477932; 12482870; 14702039; 15164054; 16385451; 18315530; 18519826; 18830724; 19241460; 19875614; 19913121; 19948975; 20379614; 20413850; 20534741; 20574532; 20628086; 20677014; 20881129; 21294870; 22046233; 22353753; 23055476; 23279143; 23472165; 23700427; 23780848; 23934736; 24128306
description: sortilin-related VPS10 domain containing receptor 1
database cross reference: Ensembl:ENSG00000108018
database cross reference: HGNC:16697
database cross reference: HPRD:12098
database cross reference: MIM:606283
database cross reference: Vega:OTTHUMG00000019018

ALPK2
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HAK
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ALPK2
full name from nomenclature authority: alpha-kinase 2
NCBI GeneID: 115701
gene map location: 18q21.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 18
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004674 (EC: IEA); GO_0005524 (EC: IEA); GO_0005634 (EC: IDA); GO_0005730 (EC: IDA, Qualifier: NOT)
has PubMed association: PMID: 10021370; 14702039; 19690890; 21833088; 21963094; 22641666
description: alpha-kinase 2
database cross reference: Ensembl:ENSG00000198796
database cross reference: HGNC:20565
database cross reference: HPRD:11019
database cross reference: Vega:OTTHUMG00000132755

CLNK
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MIST
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CLNK
full name from nomenclature authority: cytokine-dependent hematopoietic cell linker
NCBI GeneID: 116449
gene map location: 4p16.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 4
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005070 (EC: NAS, PMID: 10744659); GO_0005515 (EC: IPI, PMID: 16273093); GO_0005622 (EC: NAS, PMID: 10744659); GO_0006955 (EC: NAS, PMID: 10744659); GO_0007169 (EC: IEA); GO_0009967 (EC: NAS, PMID: 10744659); GO_0035556 (EC: IDA, PMID: 10744659)
has PubMed association: PMID: 10562326; 10744659; 11463797; 12477932; 14702039; 16273093; 18987618; 20379614; 22561518
description: cytokine-dependent hematopoietic cell linker
database cross reference: HGNC:17438
database cross reference: HPRD:14720
database cross reference: MIM:611434

SLC24A4
type: Class
subclass of: protein-coding gene of Homo sapiens
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: NCKX4
alternative term: SHEP6
alternative term: SLC24A2
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: SLC24A4
full name from nomenclature authority: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
NCBI GeneID: 123041
gene map location: 14q32.12
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 14
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005886 (EC: TAS); GO_0006811 (EC: TAS); GO_0006874 (EC: IEA); GO_0007608 (EC: ISS); GO_0008273 (EC: IEA); GO_0015293 (EC: IEA); GO_0016021 (EC: IEA); GO_0050896 (EC: IEA); GO_0055085 (EC: TAS); GO_0097186 (EC: ISS)
has PubMed association: PMID: 12379639; 12477932; 14702039; 15489334; 17952075; 18483556; 19609347; 19710684; 20379614; 20585627; 21126331; 21546767; 23375655; 23548203
description: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
database cross reference: HGNC:10978
database cross reference: HPRD:15353
database cross reference: MIM:609840

MS4A6E
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MS4A6E
full name from nomenclature authority: membrane-spanning 4-domains, subfamily A, member 6E
NCBI GeneID: 245802
gene map location: 11q12.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0016021 (EC: IEA)
has PubMed association: PMID: 11486273; 12477932; 15489334; 17207965; 21460841
description: membrane-spanning 4-domains, subfamily A, member 6E

CALHM1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: FAM26C
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CALHM1
full name from nomenclature authority: calcium homeostasis modulator 1
NCBI GeneID: 255022
gene map location: 10q24.33
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 10
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0005227 (EC: IDA); GO_0005244 (EC: IDA); GO_0005262 (EC: IEA); GO_0005789 (EC: IEA); GO_0005887 (EC: IDA); GO_0006812 (EC: IDA); GO_0015867 (EC: ISS); GO_0034765 (EC: IDA); GO_0042802 (EC: IPI, PMID: 18585350); GO_0050913 (EC: ISS); GO_0050916 (EC: ISS); GO_0050917 (EC: ISS); GO_0051260 (EC: IDA)
has PubMed association: PMID: 12477932; 15164054; 15489334; 18585350; 18667147; 19038093; 19070563; 19191331; 19191332; 19472444; 19545933; 19655363; 19944073; 20005921; 20061624; 20164573; 20164592; 20164602; 20534741; 20574532; 20592574; 20634593; 20847397; 21378601; 21439911; 21574960; 21629967; 22874670; 23300080; 23345406; 23467090; 23884934; 23974872
description: calcium homeostasis modulator 1
database cross reference: Ensembl:ENSG00000185933
database cross reference: HGNC:23494
database cross reference: HPRD:16879
database cross reference: MIM:612234
database cross reference: Vega:OTTHUMG00000018991

HLA-S
type: Class
subclass of: pseudo gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: HLA-17
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: HLA-S
full name from nomenclature authority: major histocompatibility complex, class I, S (pseudogene)
NCBI GeneID: 267015
gene map location: 6p21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 6
type of gene: pseudo
nomenclature status: Official from a nomenclature committee
has PubMed association: PMID: 1517563; 10452889
description: major histocompatibility complex, class I, S (pseudogene)
database cross reference: HGNC:19395

USP17L2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: DUB-3
alternative term: DUB3
alternative term: USP17
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: USP17L2
full name from nomenclature authority: ubiquitin specific peptidase 17-like family member 2
NCBI GeneID: 377630
gene map location: 8p23.1
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 8
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000075 (EC: IMP); GO_0004221 (EC: IMP); GO_0004843 (EC: IDA); GO_0004843 (EC: IMP, PMID: 19188362); GO_0005515 (EC: IPI); GO_0005634 (EC: IDA); GO_0005789 (EC: IDA, PMID: 19188362); GO_0006511 (EC: IEA); GO_0006915 (EC: IEA); GO_0007093 (EC: IMP); GO_0010955 (EC: IMP, PMID: 19188362); GO_0016579 (EC: IDA); GO_0030334 (EC: IMP); GO_0031064 (EC: IMP); GO_0032321 (EC: IMP); GO_0034261 (EC: IDA, PMID: 19188362); GO_0042127 (EC: IMP, PMID: 19188362); GO_0042981 (EC: IMP); GO_0050691 (EC: IMP); GO_0070536 (EC: IDA); GO_0070536 (EC: IMP, PMID: 19188362); GO_0071108 (EC: IMP, PMID: 19188362); GO_0071586 (EC: IMP, PMID: 19188362); GO_0090315 (EC: IMP, PMID: 19188362); GO_1900027 (EC: IMP); GO_1900245 (EC: IMP); GO_1900246 (EC: IMP)
has PubMed association: PMID: 9806828; 10936051; 11941478; 14699124; 15780755; 16611142; 17109758; 19188362; 19615732; 19718026; 20147298; 20228807; 20228808; 20368735; 20388806; 20403174; 20715989; 21239494; 21448158
description: ubiquitin specific peptidase 17-like family member 2
database cross reference: Ensembl:ENSG00000223443
database cross reference: HGNC:34434
database cross reference: HPRD:16844
database cross reference: MIM:610186
database cross reference: Vega:OTTHUMG00000165295

MIR128-1
type: Class
subclass of: RNA gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: MIR128A
alternative term: MIRN128-1
alternative term: MIRN128A
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: MIR128-1
full name from nomenclature authority: microRNA 128-1
NCBI GeneID: 406915
gene map location: 2q21.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 2
type of gene: ncRNA
nomenclature status: Official from a nomenclature committee
has PubMed association: PMID: 12007417; 15325244; 16381832; 17604727; 18056805; 18381601; 19048628; 19713529; 19955085; 20054641; 20889907; 21228036; 21358821; 21596314; 22614013; 23034410; 23482671; 23492773; 23958464
description: microRNA 128-1
database cross reference: HGNC:31510
database cross reference: MIM:611774
database cross reference: miRBase:MI0000447

CCR2
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CC-CKR-2
alternative term: CCR-2
alternative term: CCR2A
alternative term: CCR2B
alternative term: CD192
alternative term: CKR2
alternative term: CKR2A
alternative term: CKR2B
alternative term: CMKBR2
alternative term: MCP-1-R
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CCR2
full name from nomenclature authority: chemokine (C-C motif) receptor 2
NCBI GeneID: 729230
NCBI LocusTag: hCG_14621
gene map location: 3p21.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 3
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0001974 (EC: ISS); GO_0002407 (EC: TAS, PMID: 16621978); GO_0002827 (EC: ISS); GO_0002829 (EC: ISS); GO_0004950 (EC: TAS, PMID: 10623817); GO_0005737 (EC: IDA, PMID: 15995708); GO_0005829 (EC: ISS); GO_0005886 (EC: IDA, PMID: 15995708); GO_0005886 (EC: TAS); GO_0005887 (EC: TAS, PMID: 8146186); GO_0006874 (EC: ISS); GO_0006935 (EC: TAS, PMID: 10623817); GO_0006954 (EC: IEA); GO_0006955 (EC: TAS, PMID: 10751368); GO_0006968 (EC: TAS, PMID: 10201901); GO_0007194 (EC: TAS, PMID: 8995400); GO_0007204 (EC: TAS, PMID: 9548499); GO_0007259 (EC: TAS, PMID: 9670957); GO_0009611 (EC: TAS, PMID: 8146186); GO_0010574 (EC: ISS); GO_0010820 (EC: ISS); GO_0016021 (EC: TAS, PMID: 8530354); GO_0016032 (EC: IEA); GO_0016493 (EC: IEA); GO_0016525 (EC: ISS); GO_0019221 (EC: IDA, PMID: 15995708); GO_0019725 (EC: ISS); GO_0030425 (EC: ISS); GO_0031727 (EC: IDA, PMID: 15995708); GO_0032729 (EC: ISS); GO_0032743 (EC: ISS); GO_0035705 (EC: ISS); GO_0042535 (EC: ISS); GO_0042803 (EC: ISS); GO_0043025 (EC: ISS); GO_0043204 (EC: ISS); GO_0043310 (EC: ISS); GO_0045087 (EC: TAS); GO_0046641 (EC: ISS); GO_0048471 (EC: ISS); GO_0050729 (EC: ISS); GO_0050870 (EC: ISS); GO_0070098 (EC: ISS); GO_0090026 (EC: IDA, PMID: 18587271); GO_0090026 (EC: ISS); GO_0090265 (EC: ISS); GO_2000439 (EC: ISS); GO_2000451 (EC: ISS); GO_2000464 (EC: IDA, PMID: 12271471); GO_2000473 (EC: ISS)
has PubMed association: PMID: 2834384; 8048929; 8146186; 8530354; 8884276; 8995400; 9058802; 9115216; 9143512; 9195948; 9225989; 9252328; 9287323; 9501202; 9548499; 9653051; 9662369; 9670957; 9710230; 9736741; 9789057; 9886417; 10201901; 10479649; 10486323; 10529171; 10623817; 10741397; 10751368; 10877489; 10888629; 10985245; 11023492; 11046064; 11115360; 11120855; 11175286; 11181995; 11264152; 11350939; 11377705; 11385319; 11468722; 11470772; 11477473; 11485615; 11500196; 11590385; 11596075; 11694103; 11696224; 11709782; 11729511; 11752157; 11756347; 11779135; 11782014; 11804551; 11856781; 11860793; 11860823; 11873083; 11898620; 11958683; 11964548; 11988632; 12001056; 12010355; 12032878; 12070001; 12078856; 12079277; 12082592; 12149192; 12192431; 12201365; 12215924; 12239249; 12271471; 12374865; 12399623; 12403355; 12426226; 12436194; 12445801; 12447757; 12469616; 12477932; 12556692; 12557141; 12571520; 12584049; 12651900; 12654703; 12680626; 12719858; 12837756; 12853162; 12853745; 12882757; 12884524; 12889997; 12913933; 13678532; 14533004; 14533983; 14624371; 14644039; 14647058; 14742283; 14981141; 15053339; 15076247; 15086346; 15086398; 15135805; 15140377; 15192276; 15230854; 15236615; 15257681; 15319853; 15362666; 15458467; 15465089; 15466648; 15472820; 15488313; 15489334; 15575507; 15579296; 15585333; 15602133; 15611878; 15639953; 15721423; 15750046; 15754978; 15769362; 15793370; 15863470; 15929697; 15976001; 15980693; 15992849; 15995708; 16033640; 16055130; 16095529; 16123688; 16140745; 16196460; 16206074; 16207551; 16261210; 16286054; 16286055; 16305685; 16314800; 16320328; 16323127; 16344560; 16356504; 16415174; 16426243; 16461193; 16478397; 16480760; 16485782; 16524739; 16529059; 16598837; 16621978; 16631114; 16641997; 16733654; 16781696; 16831471; 16858645; 16865553; 16903979; 16908772; 16950632; 17060059; 17091019; 17094383; 17135764; 17216598; 17240189; 17295203; 17298432; 17355643; 17361671; 17364026; 17395051; 17413295; 17417600; 17426779; 17428349; 17464174; 17465499; 174821…
description: chemokine (C-C motif) receptor 2
database cross reference: Ensembl:ENSG00000121807
database cross reference: HGNC:1603
database cross reference: MIM:601267
database cross reference: Vega:OTTHUMG00000156466

ZGLP1
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: GATAD3
alternative term: GLP-1
alternative term: GLP1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: ZGLP1
full name from nomenclature authority: zinc finger, GATA-like protein 1
NCBI GeneID: 100125288
gene map location: 19p13.2
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 19
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0000122 (EC: IEA); GO_0003700 (EC: IEA); GO_0005634 (EC: IEA); GO_0006351 (EC: IEA); GO_0007275 (EC: IEA); GO_0007283 (EC: IEA); GO_0008270 (EC: IEA); GO_0043565 (EC: IEA); GO_0048599 (EC: IEA)
has PubMed association: PMID: 12477932; 14702039; 15057824; 15489334; 16982049
description: zinc finger, GATA-like protein 1
database cross reference: Ensembl:ENSG00000220201
database cross reference: HGNC:37245
database cross reference: MIM:611639
database cross reference: Vega:OTTHUMG00000152114

MS4
type: Class
subclass of: gene of Homo sapiens with unknown gene disposition
subclass of: Restriction
  on property: VariantisGeneticRiskFactorFor
  some values from: Alzheimer's disease
definition editor: Bin Zhao, Yue Liu, Oliver He
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
NCBI GeneID: 100271696
gene map location: 1p36
modification date: 20140305
organism NCBITaxon ID: 9606
chromosome ID of gene: 1
type of gene: unknown
nomenclature status: NCBI-supplied
description: Multiple sclerosis, susceptiblity to, 4

CASP12
type: Class
subclass of: protein-coding gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: CASP-12
alternative term: CASP12P1
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: CASP12
full name from nomenclature authority: caspase 12 (gene/pseudogene)
NCBI GeneID: 100506742
NCBI LocusTag: UNQ9415
gene map location: 11q22.3
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 11
type of gene: protein-coding
nomenclature status: Official from a nomenclature committee
has GO association: GO_0004197 (EC: IBA); GO_0005737 (EC: IBA); GO_0030968 (EC: IEA); GO_0042981 (EC: IEA); GO_0050727 (EC: IBA, Qualifier: NOT); GO_0070059 (EC: IBA); GO_0072557 (EC: IBA, Qualifier: NOT); GO_0072559 (EC: IBA, Qualifier: NOT); GO_0097169 (EC: IBA, Qualifier: NOT); GO_0097194 (EC: IBA, Qualifier: NOT)
has PubMed association: PMID: 9038361; 11278723; 11329013; 11943137; 12054529; 12975309; 14532116; 15033764; 15129283; 16532395; 16917906; 17574210; 18329614; 18332441; 18710920; 18791174; 19447924; 19721713; 20031604; 20041182; 20299359; 20299368; 20423816; 20577092; 20646990; 21706251; 21872999
description: caspase 12 (gene/pseudogene)
database cross reference: Ensembl:ENSG00000204403
database cross reference: HGNC:19004
database cross reference: MIM:608633
database cross reference: Vega:OTTHUMG00000154965

LINC-ROR
type: Class
subclass of: RNA gene of Homo sapiens
definition editor: Bin Zhao, Yue Liu, Oliver He
alternative term: lincRNA-RoR
definition source: WEB: http://www.ncbi.nlm.nih.gov/gene
imported from: ogg.owl
symbol from nomenclature authority: LINC-ROR
full name from nomenclature authority: long intergenic non-protein coding RNA, regulator of reprogramming
NCBI GeneID: 100885779
gene map location: 18q21.31
modification date: 20140408
organism NCBITaxon ID: 9606
chromosome ID of gene: 18
type of gene: ncRNA
nomenclature status: Official from a nomenclature committee
has PubMed association: PMID: 21057500; 23208419; 23541921; 23597480; 24463816
description: long intergenic non-protein coding RNA, regulator of reprogramming
database cross reference: Ensembl:ENSG00000258609
database cross reference: HGNC:43773
database cross reference: MIM:615173

clinical finding
type: Class
subclass of: clinical data item
definition: A representation that is either the output of a clinical history taking or a physical examination or an image finding, or some combination thereof.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2010-07-19T10:18:02Z
imported from: mfomd.owl
imported from: ogms.owl

clinical history
type: Class
subclass of: clinical data item
definition: A series of statements representing health-relevant qualities of a patient and of a patient's family.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2010-07-19T10:18:59Z
imported from: ogms.owl

laboratory finding
type: Class
subclass of: clinical finding
definition: A representation of a quality of a specimen that is the output of a laboratory test and that can support an inference to an assertion about some quality of the patient.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T10:21:58Z
imported from: mfomd.owl

phenotype
type: Class
subclass of: quality
definition: A (combination of) quality(ies) of an organism determined by the interaction of its genetic make-up and environment that differentiates specific instances of a species from other instances of the same species.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2010-07-19T11:13:49Z
imported from: ogms.owl

sign
type: Class
subclass of: entity
definition: A quality of a patient, a material entity that is part of a patient, or a processual entity that a patient participates in, any one of which is observed in a physical examination and is deemed by the clinician to be of clinical significance.
editor note: note: defined class
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2010-11-18T11:14:36Z
imported from: ogms.owl

vital sign
type: Class
subclass of: sign
definition: A physical sign in which a non-zero value is standardly considered to be an indication that the organism is alive.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T11:19:17Z
imported from: ogms.owl

disease
type: Class
subclass of: disposition
definition: A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T11:21:20Z
imported from: ogms.owl

homeostasis
type: Class
subclass of: disposition
definition: Homeostasis is defined as the property of a system in which variables are regulated so that internal conditions remain stable and relatively constant. Examples of homeostasis include the regulation of body temperature, and the balance between acidity and alkalinity. It is a process that maintains the stability of the organism’s internal environment in response to fluctuations in external environmental conditions.
definition editor: Albert Goldfain
curator note: creation date: 2009-06-23T11:22:01Z
imported from: ogms.owl

Axiom
annotated source: homeostasis
annotated property: definition
annotated target: Homeostasis is defined as the property of a system in which variables are regulated so that internal conditions remain stable and relatively constant. Examples of homeostasis include the regulation of body temperature, and the balance between acidity and alkalinity. It is a process that maintains the stability of the organism’s internal environment in response to fluctuations in external environmental conditions.

abnormal homeostasis
type: Class
subclass of: homeostasis
definition: Homeostasis that is clinically abnormal for an organism of a given type and age in a given environment.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T11:26:44Z
imported from: ogms.owl

disorder
type: Class
subclass of: material entity
definition: A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T11:39:44Z
imported from: ogms.owl

physical examination
type: Class
subclass of: health care process
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
definition: A sequence of acts of observing and measuring qualities of a patient performed by a clinician; measurements may occur with and without elicitation.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2010-07-19T11:50:18Z
imported from: ogms.owl

bodily process
type: Class
subclass of: process
definition: A process in which at least one bodily component of an organsim participates.
definition editor: Albert Goldfain
definition source: http://www.jbiomedsem.com/content/1/1/10
curator note: creation date: 2009-06-23T11:53:49Z
imported from: mfomd.owl
imported from: oae.owl
imported from: ogms.owl
comment: From OGMS: http://purl.obolibrary.org/obo/OGMS_0000060

pathological bodily process
type: Class
subclass of: bodily process
definition: A bodily process that is clinically abnormal.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T11:54:29Z
imported from: mfomd.owl
imported from: oae.owl
imported from: ogms.owl

diagnosis
type: Class
subclass of: clinical data item
definition: The representation of a conclusion of a diagnostic process.
definition editor: Albert Goldfain
definition source: http://ontology.buffalo.edu/medo/Disease_and_Diagnosis.pdf
curator note: creation date: 2009-06-23T12:42:23Z
imported from: ogms.owl

physical examination finding
type: Class
subclass of: clinical finding
definition: TODO: Define.
definition: The information regarding anatomic findings obtained through the use of observation, palpation, percussion, and auscultation.
definition editor: Albert Goldfain
definition source: http://code.google.com/p/ogms/issues/detail
curator note: creation date: 2009-11-24T04:51:11Z
imported from: mfomd.owl
imported from: ogms.owl
comment on definition: Modified definition

treatment
type: Class
subclass of: planned process
subclass of: Restriction
  on property: isTreatmentFor
  some values from: Alzheimer's disease
definition: A planned process whose completion is hypothesized by a health care provider to eliminate, prevent, or alleviate the signs and symptoms of a disorder or pathological process
definition editor: Albert Goldfain
definition source: http://code.google.com/p/ogms/issues/detail
curator note: creation date: 2010-03-31T04:51:11Z
imported from: ogms.owl

inflammatory process
type: Class
subclass of: pathological bodily process
definition: A bodily process caused by some disorder that results in recruitment of leukocytes into a localized tissue site, typically causing localized pain and swelling.
definition editor: Albert Goldfain Richard Scheuermann Sagar Jain
definition source: http://code.google.com/p/ogms/wiki/Meeting_notes_20100513
curator note: creation date: 2010-07-19T11:57:44Z Updated: 10 NOV 2015
imported from: ogms.owl

health care process
type: Class
subclass of: planned process
definition: A planned process with the objective to improve the health status of a patient that directly involves the treatment, diagnosis, or prevention of disease or injury of a patient
definition editor: Albert Goldfain Sagar Jain
definition source: http://groups.google.com/group/ogms-discuss/browse_thread/thread/a2dbc2ed1dff99d6
curator note: creation date: 2011-02-21T09:57:44Z editor date: 2017-04-18
imported from: ogms.owl

therapeutic procedure
type: Class
subclass of: treatment
definition: A treatment whose completion is hypothesized by a health care provider to eliminate a disorder or to alleviate the signs and symptoms of a disorder or pathological process.
curator note: Creation data: 2018-11-27
imported from: ogms.owl

onset
type: Class
subclass of: disease stage
definition: A disease stage that marks the beginning of a disease
curator note: creation date 2018-11-27
imported from: ogms.owl

clinical data item
type: Class
subclass of: data item
definition: a data item that is about a patient and is the specified output of a health care process assay or diagnostic process
curator note: creation date: 2018-11-27
imported from: mfomd.owl
imported from: ogms.owl

population based study design
type: Class
subclass of: study design
definition: A study design that is multidisciplinary done at the population level or among the population groups, generally to find the cause, incidence or spread of the disease or to see the response to the treatment, nutrition or environment.
definition editor: Alice Nzinga
imported from: omiabis.owl

Pathogen-Associated Molecular Pattern Molecules
type: Class
subclass of: biomarker
imported from: omit.owl

Adenine Nucleotides
type: Class
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
imported from: omit.owl

Adenosine Diphosphate
type: Class
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
imported from: omit.owl

Adenosine Monophosphate
type: Class
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
imported from: omit.owl

Blood Proteins
type: Class
subclass of: protein
imported from: omit.owl

Cell Cycle
type: Class
subclass of: cellular process
imported from: omit.owl

Cholinesterase Inhibitors
type: Class
subclass of: enzyme inhibitor
imported from: omit.owl

Chylomicrons
type: Class
subclass of: lipoprotein particle
imported from: omit.owl

Diagnosis, Differential
type: Class
subclass of: diagnosis
imported from: omit.owl

Galantamine
type: Class
subclass of: cholinesterase inhibitor therapy
imported from: omit.owl

Guanine Nucleotides
type: Class
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
imported from: omit.owl

Guanosine Diphosphate
type: Class
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
imported from: omit.owl

Guanosine Monophosphate
type: Class
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
imported from: omit.owl

Guanosine Triphosphate
type: Class
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
subclass of: organonitrogen compound
imported from: omit.owl

Hexokinase
type: Class
subclass of: enzyme
imported from: omit.owl

Interphase
type: Class
subclass of: Cell Cycle
imported from: omit.owl

Brief Psychiatric Rating Scale
type: Class
subclass of: Clinical or Research Assessment Questionnaire
subclass of: Restriction
  on property: isDiagnosisFor
  some values from: Alzheimer's disease
imported from: omit.owl

Type C Phospholipases
type: Class
subclass of: enzyme
imported from: omit.owl

Phospholipase D
type: Class
subclass of: enzyme
imported from: omit.owl

Pyruvate Dehydrogenase Complex
type: Class
subclass of: catalytic complex
imported from: omit.owl

Lipid Peroxidation
type: Class
subclass of: disposition
imported from: omit.owl

Complement C1q
type: Class
subclass of: Complement Component Protein
imported from: omit.owl

Complement C3a
type: Class
subclass of: Complement Component Protein
imported from: omit.owl

Cohort Effect
type: Class
subclass of: quality
imported from: omit.owl

Placebo Effect
type: Class
subclass of: quality
imported from: omit.owl

G0 Phase
type: Class
subclass of: Interphase
imported from: omit.owl

G1 Phase
type: Class
subclass of: Interphase
imported from: omit.owl

G2 Phase
type: Class
subclass of: Interphase
imported from: omit.owl

Antigens, CD45
type: Class
subclass of: immune biomarker
imported from: omit.owl

GTP-Binding Protein Regulators
type: Class
subclass of: protein
imported from: omit.owl

Guanine Nucleotide Exchange Factors
type: Class
subclass of: protein
imported from: omit.owl

Lipid Metabolism
type: Class
subclass of: metabolism
imported from: omit.owl

Complement C5b
type: Class
subclass of: Complement Component Protein
imported from: omit.owl

DNA Fragmentation
type: Class
subclass of: disposition
imported from: omit.owl

Diffusion Tensor Imaging
type: Class
subclass of: Magnetic Resonance Imaging
imported from: omit.owl

Sirtuin 1
type: Class
subclass of: receptor
imported from: omit.owl

Endophenotypes
type: Class
subclass of: phenotype
definition: An endophenotype (also known as intermediate phenotype) is a quantitative biological trait that is reliable in reflecting the function of a discrete biological system and is reasonably heritable, and as such is more closely related to the root cause of the disease than the broad clinical phenotype.
imported from: omit.owl

Axiom
annotated source: Endophenotypes
annotated property: definition
annotated target: An endophenotype (also known as intermediate phenotype) is a quantitative biological trait that is reliable in reflecting the function of a discrete biological system and is reasonably heritable, and as such is more closely related to the root cause of the disease than the broad clinical phenotype.

Receptors, Ionotropic Glutamate
type: Class
subclass of: receptor
imported from: omit.owl

Cholinergic Neurons
type: Class
subclass of: neuron
imported from: omit.owl

Cell Cycle Checkpoints
type: Class
subclass of: Cell Cycle
imported from: omit.owl

G2 Phase Cell Cycle Checkpoints
type: Class
subclass of: G2 Phase
subclass of: Cell Cycle Checkpoints
imported from: omit.owl

G1 Phase Cell Cycle Checkpoints
type: Class
subclass of: G1 Phase
subclass of: Cell Cycle Checkpoints
imported from: omit.owl

Neuroimaging
type: Class
subclass of: Diagnostic Imaging
definition: Non-invasive methods of visualizing the central nervous system, especially the brain, by various imaging modalities.
imported from: omit.owl

Axiom
annotated source: Neuroimaging
annotated property: definition
annotated target: Non-invasive methods of visualizing the central nervous system, especially the brain, by various imaging modalities.

Functional Neuroimaging
type: Class
subclass of: Neuroimaging
definition: Methods for visualizing regional blood flow, metabolic, electrical, or other physiological activities in the central nervous system using various imaging modalities.
imported from: omit.owl

Axiom
annotated source: Functional Neuroimaging
annotated property: definition
annotated target: Methods for visualizing regional blood flow, metabolic, electrical, or other physiological activities in the central nervous system using various imaging modalities.

Immunoreceptor Tyrosine-Based Activation Motif
type: Class
subclass of: material entity
imported from: omit.owl

Cohort Study
type: Class
subclass of: study design
definition: Data are obtained from groups who have been exposed, or not exposed, to the new technology or factor of interest (eg from databases). No allocation of exposure is made by the researcher. Best for study the effect of predictive risk factors on an outcome.
definition editor: ENPADASI_WP4
imported from: ons.owl
in minimal requirement ONS subset: true

Cross-Sectional Survey
type: Class
subclass of: study design
definition: A study that examines the relationship between diseases (or other health-related characteristics) and other variables of interest as they exist in a defined population at one particular time (ie exposure and outcomes are both measured at the same time). Best for quantifying the prevalence of a disease or risk factor, and for quantifying the accuracy of a diagnostic test.
definition editor: ENPADASI_WP4
imported from: ons.owl
in minimal requirement ONS subset: true

biomarker
type: Class
subclass of: material entity
definition: A material entity that has a measurable quality or process profile(s), which can be used as an indicator of an underlying biological state or identity.
editor note: The NIH Biomarkers and Surrogate Endpoint Working Group defined a biomarker as “A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention” (https://pubmed.ncbi.nlm.nih.gov/11240971/). However, the definition of 'characteriistc' is unclear, so we do not use the exact definintion in the ontology.
definition editor: Yingtong Liu, Anthony Huffman, Oliver He
definition source: https://en.wikipedia.org/wiki/Biomarker
definition source: https://en.wikipedia.org/wiki/Biomarker_(cell)
definition source: https://en.wikipedia.org/wiki/Biomarker_(medicine)
imported from: opmi.owl

immune biomarker
type: Class
subclass of: biomarker
definition editor: Anthony Huffman, Oliver He
definition source: A biomarker that is indicative of an immune response
definition source: https://pubmed.ncbi.nlm.nih.gov/22072636/
definition source: https://pubmed.ncbi.nlm.nih.gov/32286245/
imported from: opmi.owl

cytokine biomarker
type: Class
subclass of: immune biomarker
definition editor: Anthony Huffman, Oliver He
imported from: opmi.owl

inflammatory cytokine biomarker
type: Class
subclass of: biomarker
subclass of: cytokine biomarker
definition editor: Anthony Huffman, Oliver He
imported from: opmi.owl

age
type: Class
subclass of: physical object quality
subclass of: Restriction
  on property: isRiskFactorFor
  some values from: Alzheimer's disease
definition: A time quality inhering in a bearer by virtue of how long the bearer has existed.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000011
in subset: attribute slim
in subset: scalar slim

biological sex
type: Class
subclass of: physical object quality
definition: An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000047
in subset: attribute slim

shape
type: Class
subclass of: physical object quality
definition: A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).
imported from: pato.owl
has_alternative_id: PATO:0001647
has exact synonym: relational shape quality
has_obo_namespace: quality
id: PATO:0000052
in subset: attribute slim
comment: Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects.

rate
type: Class
subclass of: quality
definition: A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000161
in subset: attribute slim
in subset: scalar slim

female
type: Class
subclass of: biological sex
definition: A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000383
in subset: mpath slim
in subset: value slim

male
type: Class
subclass of: biological sex
definition: A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes.
imported from: pato.owl
has_obo_namespace: quality
id: PATO:0000384
in subset: mpath slim
in subset: value slim

truncated
type: Class
subclass of: shape
definition: A shape quality inhering in a bearer by virtue of the bearer's terminating abruptly by having or as if having an end or point cut off.
imported from: pato.owl
has exact synonym: truncate
has_obo_namespace: quality
id: PATO:0000936
in subset: value slim

physical object quality
type: Class
subclass of: quality
definition: A quality which inheres in a continuant.
imported from: pato.owl
has_alternative_id: PATO:0001237
has_alternative_id: PATO:0001238
database cross reference: snap:Quality
has exact synonym: monadic quality of a continuant
has exact synonym: multiply inhering quality of a physical entity
has exact synonym: quality of a continuant
has exact synonym: quality of a single physical entity
has exact synonym: quality of an object
has exact synonym: quality of continuant
has_narrow_synonym: monadic quality of an object
has_narrow_synonym: monadic quality of continuant
has_obo_namespace: quality
id: PATO:0001241
comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles.

presynaptic terminal
type: Class
subclass of: cellular_component
definition: Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
imported from: plana.owl
created by: https://orcid.org/0000-0003-2569-1939 | https://orcid.org/0000-0002-7535-4407
database cross reference: GO:0043195
database cross reference: PMID:23903188
has exact synonym: pre-synaptic terminal
has_obo_namespace: Planarian_Anatomy

protein
type: Class
subclass of: material entity
definition: An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
imported from: pr.owl
has exact synonym: natural protein
has_narrow_synonym: native protein
has_obo_namespace: protein
id: PR:000000001
comment: The definition above excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to CHEBI:36080. Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB].

NFAT protein
type: Class
subclass of: protein
definition: A protein that contains a Rel homology domain (RHD) (Pfam:PF00554) followed by an IPT/TIG domain (Pfam:PF01833).
imported from: pr.owl
database cross reference: PANTHER:PTHR12533
has_obo_namespace: protein
id: PR:000003112
comment: Category=family.

amyloid-beta precursor protein
type: Class
subclass of: protein
definition: A protein that is a translation product of the human APP gene or a 1:1 ortholog thereof.
imported from: pr.owl
has exact synonym: ABPP
has exact synonym: AG
has exact synonym: APP
has exact synonym: APPI
has exact synonym: CVAP
has exact synonym: PN-II
has exact synonym: PreA4
has exact synonym: alzheimer disease amyloid A4 protein homolog
has exact synonym: alzheimer disease amyloid protein
has exact synonym: amyloid beta A4 protein
has exact synonym: amyloid precursor protein
has exact synonym: amyloid-beta A4 protein
has exact synonym: amyloidogenic glycoprotein
has exact synonym: cerebral vascular amyloid peptide
has exact synonym: protease nexin-II
has_obo_namespace: protein
has_related_synonym: A4
has_related_synonym: AD1
id: PR:000004168
comment: Category=gene. Requested by=Alzforum.

proteolytic cleavage product
type: Class
subclass of: protein
definition: A protein that is produced as the result of proteolytic processing of a longer protein.
imported from: pr.owl
has exact synonym: ClvPrd
has_narrow_synonym: peptide
has_narrow_synonym: polypeptide
has_obo_namespace: protein
id: PR:000018264

neurotrophin
type: Class
subclass of: protein
definition: A protein that is a neurotrophic polypeptide factor that regulates neuronal differentiation and is essential for neuronal survival, neurite growth and plasticity. It contains a signal peptide, a propeptide, and a C-terminal Nerve growth factor family (Pfam:PF00243) domain.
imported from: pr.owl
database cross reference: PIRSF:PIRSF001789
has_obo_namespace: protein
id: PR:000021998
comment: Category=family.

C99
type: Class
subclass of: Complement Component Protein
subclass of: amyloid-beta precursor protein
definition: An amyloid-beta precursor protein proteolytic cleavage product that is the C-terminal product of cleavage by beta-secretase of certain amyloid-beta precursor protein isoforms, signal peptide removed form. Example: UniProtKB:P05067-1, 672-770.
imported from: pr.owl
has exact synonym: APP-C99
has_obo_namespace: protein
id: PR:000025580
comment: Category=modification. Requested by=Alzforum.

C83
type: Class
subclass of: Complement Component Protein
subclass of: amyloid-beta precursor protein
definition: An amyloid-beta precursor protein proteolytic cleavage product that is the C-terminal product of cleavage by alpha-secretase of certain amyloid-beta precursor protein isoforms, signal peptide removed form. Example: UniProtKB:P05067-1, 688-770.
imported from: pr.owl
has exact synonym: APP-C83
has_obo_namespace: protein
id: PR:000025581
comment: Category=modification. Requested by=Alzforum.

pathway
type: Class
subclass of: signal transduction
definition: A pathway is a set of inter-connected reactions and interactions whose delineation and scope are used as a model for exploring and studying, describing and understanding the working of and relationships between biomolecules within a context.
imported from: pw.owl
has_obo_namespace: pathway
id: PW:0000001

Wnt signaling pathway
type: Class
subclass of: pathway
definition: The secreted glycoproteins of the Wnt family regulate a wide spectrum of developmental processes and they are also playing important roles in the adult organism. Deregulation of Wnt cascades has oncogenic effects and is responsible for tumorigenesis in adults.
imported from: pw.owl
has_obo_namespace: pathway
has_related_synonym: KEGG:04310
id: PW:0000008

insulin signaling pathway
type: Class
subclass of: pathway
definition: Insulin, the peptide hormone, secreted by the pancreatic beta cells, plays essential roles in glucose and energy homeostasis. Insulin signaling activates two main intracellular pathways to regulate carbohydrate and fat metabolism and to prompt glucose absorption in insulin sensitive tissues such as skeletal muscle and adipocytes. Deregulation of the pathway has been associated with a number of conditions, primarily diabetes.
imported from: pw.owl
has_obo_namespace: pathway
has_related_synonym: KEGG:04910
has_related_synonym: PID:200014
has_related_synonym: SMP:00391
id: PW:0000143

mTOR signaling pathway
type: Class
subclass of: pathway
definition: mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated or responds to growth factors, energy metabolites and/or levels of nutrients.
imported from: pw.owl
has_obo_namespace: pathway
has_related_synonym: KEGG:04150
has_related_synonym: PID:200096
id: PW:0000180

synaptic vesicle exocytosis pathway
type: Class
subclass of: pathway
definition: The release pathway of neurotransmitter filled synaptic vesicles.
imported from: pw.owl
created by: VPetri
creation date: 2016-01-14T11:49:08Z
has_obo_namespace: pathway
id: PW:0002425

active transport
type: Class
subclass of: cellular process
definition: The carriage of a solute across a biological membrane from low to high concentration which requires the expenditure of (metabolic) energy.
imported from: rex.owl
has_obo_namespace: rex.oboInOwl
id: REX:0000120

Comparative Study
type: Class
subclass of: Clinical Study
definition: Comparison of outcomes, results, responses, etc for different techniques, therapeutic approaches or other inputs.
imported from: scdo.owl
definition source: http://purl.bioontology.org/ontology/MESH/D003160
existence in other ontologies: Sufficient
previous identifier: SCDO:0000268
database cross reference: MESH:D003160
has exact synonym: Comparative Studies

Kidney Function Test
type: Class
subclass of: diagnostic test
definition: Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.
imported from: scdo.owl
definition source: http://purl.bioontology.org/ontology/MESH/D007677
existence in other ontologies: Sufficient
previous identifier: SCDO:0000676
database cross reference: MESH:D007677
has exact synonym: Kidney Function Tests
has exact synonym: Renal Function Test
has exact synonym: Renal Function Tests

promoter
type: Class
subclass of: gene
definition: A regulatory_region composed of the TSS(s) and binding sites for TF_complexes of the core transcription machinery. A region (DNA) to which RNA polymerase binds, to begin transcription.
imported from: so.owl
has_broad_synonym: INSDC_feature:regulatory
database cross reference: http://en.wikipedia.org/wiki/Promoter
has exact synonym: INSDC_qualifier:promoter
has exact synonym: promoter sequence
has_obo_namespace: sequence
id: SO:0000167
in subset: SOFA
comment: This term is mapped to MGED. Do not obsolete without consulting MGED ontology. The region on a DNA molecule involved in RNA polymerase binding to initiate transcription. Moved from is_a: SO:0001055 transcriptional_cis_regulatory_region as per request from GREEKC initiative in August 2020. Merged with RNA_polymerase_promoter (SO:0001203) Aug 2020. Moved up one level from is_a CRM (SO:0000727) to is_a transcriptional_cis_regulatory_region (SO:0001055) as part of the GREEKC work January 2021. Pascale Gaudet from Gene Ontology pointed out that CRM can be located upstream of the promoter and therefore cannot include the promoter.

miRNA
type: Class
subclass of: RNA gene
definition: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene (or the product of other non coding RNA genes. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (usually via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.
imported from: so.owl
has_alternative_id: SO:0000649
has_broad_synonym: INSDC_feature:ncRNA
database cross reference: http://en.wikipedia.org/wiki/MiRNA
database cross reference: http://en.wikipedia.org/wiki/StRNA
has exact synonym: INSDC_qualifier:miRNA
has exact synonym: micro RNA
has exact synonym: microRNA
has exact synonym: small temporal RNA
has exact synonym: stRNA
has_obo_namespace: sequence
id: SO:0000276
in subset: SOFA

case-control study design
type: Class
subclass of: study design
has curation status: IAO_0000125
definition: a case-control study design is a observation study design which assess the risk of particular outcome (a trait or a disease) associated with an event (either an exposure or endogenous factor). A case-control study design therefore declares an exposure variable which is dichotomous in nature (exposed/non-exposed) and an outcome variable, which is also dichotomous (case or control), thus giving the name to the design. During the execution of the design, a case control study defines a population and counts the events to determine their frequency.
definition editor: Alejandra Gonzalez-Beltran
definition editor: Orlaith Burke
definition editor: Philippe Rocca-Serra
definition source: STATO, adapted from: http://www.drcath.net/toolkit/casecontrol.html
imported from: stato.owl

odds ratio
type: Class
subclass of: ratio
has curation status: IAO_0000122
definition: Odds ratio is a ratio that measures effect size, that is the strength of association between 2 dichotomous variables, one describing an exposure and one describing an outcome. It represents the odds that an outcome will occur given a particular exposure, compared to the odds of the outcome occurring in the absence of that exposure ( the probability of the event occuring divided by the probability of an event not occurring). The odds ratio is a ratio of describing the strength of association or non-independence between two binary data values by forming the ratio of the odds for the first group and the odds for the second group. Odds ratio are used when one wants to compare the odds of something occurring to two different groups.
definition editor: Alejandra Gonzalez-Beltran
definition editor: Orlaith Burke
definition editor: Philippe Rocca-Serra
definition source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938757/ http://www.stats.org/stories/2008/odds_ratios_april4_2008.html
imported from: stato.owl
STATO alternative term: OR

ratio
type: Class
subclass of: information content entity
has curation status: IAO_0000125
definition: A ratio is a data item which is formed with two numbers r and s is written r/s, where r is the numerator and s is the denominator. The ratio of r to s is equivalent to the quotient r/s.
editor note: review formal definition as both numerator and denominator should be of the same type, not just some data item
definition editor: Alejandra Gonzalez-Beltran
definition editor: Orlaith Burke
definition editor: Philippe Rocca-Serra
definition source: adapted from Wolfram Alpha: https://www.wolframalpha.com/share/clip?f=d41d8cd98f00b204e9800998ecf8427efdcsig76g7
imported from: stato.owl

prevalence
type: Class
subclass of: ratio
has curation status: IAO_0000122
definition: prevalence is a ratio formed by the number of subjects diagnosed with a disease divided by the total population size.
definition editor: Philippe Rocca-Serra
definition source: adapted from: https://www.health.ny.gov/diseases/chronic/basicstat.htm
imported from: stato.owl

incidence
type: Class
subclass of: ratio
has curation status: IAO_0000122
definition: Incidence is the ratio of the number of new cases of a disease divided by the number of persons at risk for the disease.
definition editor: Philippe Rocca-Serra
definition source: adapted from: https://www.health.ny.gov/diseases/chronic/basicstat.htm
imported from: stato.owl

mortality
type: Class
subclass of: ratio
has curation status: IAO_0000122
definition: mortality is a ratio formed by the number of deaths due to a disease divided by the total population size.
definition editor: Philippe Rocca-Serra
definition source: adapted from: https://www.health.ny.gov/diseases/chronic/basicstat.htm
imported from: stato.owl

confusion
type: Class
subclass of: neurological and physiological symptom
definition: Confusion is a neurological and physiological symptom characterized by a disturbance of consciousness characterized by inability to engage in orderly thought or by lack of power to distinguish, choose, or act decisively.
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0000016

depression
type: Class
subclass of: neurological and physiological symptom
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0000022

drowsiness
type: Class
subclass of: neurological and physiological symptom
imported from: symp.owl
has exact synonym: drowsy
has exact synonym: somnolence
has_obo_namespace: symptoms
id: SYMP:0000024

inflammation
type: Class
subclass of: general symptom
definition: Inflammation is a general symptom where there is a local response to cellular injury that is marked by capillary dilatation, leukocytic infiltration, redness, heat, pain, swelling, and often loss of function and that serves as a mechanism initiating the elimination of noxious agents and of damaged tissue.
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0000061

pain
type: Class
subclass of: nervous system symptom
definition: A sensation perception where there is an unpleasant sensation that usually indicates the body is threatened or damaged. The sensation may be sharp or dull, short-lived or chronic, intermittent or continual, confined to one area or spread over the entire body.
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0000099

seizure
type: Class
subclass of: nervous system symptom
imported from: symp.owl
has exact synonym: seizure
has_obo_namespace: symptoms
id: SYMP:0000124

necrosis
type: Class
subclass of: general symptom
definition: Necrosis is a general symptom where death of a portion of tissue differentially affected by local injury (as loss of blood supply, corrosion, burning, or the local lesion of a disease).
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0000132

weight loss
type: Class
subclass of: nutrition, metabolism, and development symptom
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0000178

complex partial seizure
type: Class
subclass of: seizure
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0000271

head symptom
type: Class
subclass of: symptom
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0000387

neurological and physiological symptom
type: Class
subclass of: symptom
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0000410

anxiety
type: Class
subclass of: neurological and physiological symptom
definition: Anxiety is a neurological and physiological symptom characterized by a painful or apprehensive uneasiness of mind usually over an impending or anticipated ill.
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0000412

urticaria
type: Class
subclass of: skin and integumentary tissue symptom
definition: Urticaria is a skin and integumentary tissue symptom characterized by raised red skin wheals (welts) commonly caused by an allergic reaction with wheals that may vary in size from about 5 mm (0.2 inches) in diameter to the size of a dinner plate that are described as severely itchy a stingnig or burning sensation, and having a pale border.
imported from: symp.owl
has exact synonym: hives
has exact synonym: nettle rash
has exact synonym: uredo
has_obo_namespace: symptoms
id: SYMP:0000434
comment: doid/symp duplicate

heartburn
type: Class
subclass of: pain
definition: Heartburn is a pain characterized by a painful burning feeling in your chest or throat that happens when stomach acid backs up into your esophagus.
imported from: symp.owl
has exact synonym: acid indigestion
has_obo_namespace: symptoms
id: SYMP:0000439

abdominal pain
type: Class
subclass of: pain
imported from: symp.owl
database cross reference: ICD9CM_2005:789.0
database cross reference: ICD9CM_2005:789.00
database cross reference: UMLS_CUI:C0000737
database cross reference: UMLS_ICD9CM_2005_AUI:A0387333
database cross reference: UMLS_ICD9CM_2005_AUI:A0637138
has_obo_namespace: symptoms
id: SYMP:0000457

nausea
type: Class
subclass of: digestive system symptom
definition: Nausea is a digestive system symptom characterized by an uneasy or unsettled feeling in the stomach together with an urge to vomit.
imported from: symp.owl
database cross reference: ICD9CM_2005:787.02
database cross reference: UMLS_CUI:C0375548
database cross reference: UMLS_ICD9CM_2005_AUI:A0750850
has_obo_namespace: symptoms
id: SYMP:0000458

digestive system symptom
type: Class
subclass of: symptom
imported from: symp.owl
database cross reference: ICD9CM_2005:787
database cross reference: SyOID:5330
database cross reference: UMLS_CUI:C0159058
database cross reference: UMLS_ICD9CM_2005_AUI:A0284224
has_obo_namespace: symptoms
id: SYMP:0000459

abdominal symptom
type: Class
subclass of: symptom
imported from: symp.owl
database cross reference: ICD9CM_2005:789
database cross reference: ICD9CM_2005:789.9
database cross reference: SyOID:12097
database cross reference: UMLS_CUI:C0159065
database cross reference: UMLS_ICD9CM_2005_AUI:A0284267
database cross reference: UMLS_ICD9CM_2005_AUI:A0284268
has_obo_namespace: symptoms
id: SYMP:0000461

symptom
type: Class
subclass of: realizable entity
subclass of: Restriction
  on property: isSignAndSymptomFor
  some values from: Alzheimer's disease
definition: A symptom is a perceived change in function, sensation, loss, disturbance or appearance reported by a patient indicative of a disease.
imported from: symp.owl
database cross reference: SyOID:14974
has_obo_namespace: symptoms
id: SYMP:0000462

nutrition, metabolism, and development symptom
type: Class
subclass of: symptom
imported from: symp.owl
database cross reference: ICD9CM_2005:783
database cross reference: SyOID:2644
database cross reference: UMLS_CUI:C0159041
database cross reference: UMLS_ICD9CM_2005_AUI:A0284163
has_obo_namespace: symptoms
id: SYMP:0000473

nervous system symptom
type: Class
subclass of: symptom
imported from: symp.owl
database cross reference: ICD9CM_2005:781
database cross reference: SyOID:90
database cross reference: UMLS_CUI:C0159033
database cross reference: UMLS_ICD9CM_2005_AUI:A0284131
has_obo_namespace: symptoms
id: SYMP:0000480

urinary system symptom
type: Class
subclass of: symptom
imported from: symp.owl
database cross reference: ICD9CM_2005:788
database cross reference: UMLS_CUI:C0476293
database cross reference: UMLS_ICD9CM_2005_AUI:A0284245
has_obo_namespace: symptoms
id: SYMP:0000486

skin and integumentary tissue symptom
type: Class
subclass of: symptom
imported from: symp.owl
database cross reference: ICD9CM_2005:782
database cross reference: ICD9CM_2005:782.9
database cross reference: UMLS_CUI:C0159037
database cross reference: UMLS_ICD9CM_2005_AUI:A0284146
database cross reference: UMLS_ICD9CM_2005_AUI:A0284161
has_obo_namespace: symptoms
id: SYMP:0000488

headache
type: Class
subclass of: pain
definition: Headache is a pain characterized by a pain in the head.
imported from: symp.owl
database cross reference: ICD9CM_2005:784.0
database cross reference: UMLS_CUI:C0018681
database cross reference: UMLS_ICD9CM_2005_AUI:A0065994
has exact synonym: cephalalgia
has_obo_namespace: symptoms
id: SYMP:0000504

general symptom
type: Class
subclass of: symptom
imported from: symp.owl
database cross reference: ICD9CM_2005:780
database cross reference: SyOID:777
database cross reference: UMLS_CUI:C0159028
database cross reference: UMLS_ICD9CM_2005_AUI:A0284119
has_obo_namespace: symptoms
id: SYMP:0000567

insomnia
type: Class
subclass of: general symptom
definition: Insomnia is a sleep disturbance characterized by prolonged and usually abnormal inability to obtain adequate sleep.
imported from: symp.owl
database cross reference: ICD9CM_2005:780.52
database cross reference: UMLS_CUI:C0029645
database cross reference: UMLS_ICD9CM_2005_AUI:A0243733
has exact synonym: agrypnia
has_obo_namespace: symptoms
id: SYMP:0000571

chest pain
type: Class
subclass of: pain
imported from: symp.owl
database cross reference: ICD9CM_2005:786.5
database cross reference: ICD9CM_2005:786.50
database cross reference: UMLS_CUI:C0008031
database cross reference: UMLS_ICD9CM_2005_AUI:A0243830
database cross reference: UMLS_ICD9CM_2005_AUI:A0400627
has_obo_namespace: symptoms
id: SYMP:0000576

dizziness
type: Class
subclass of: neurological and physiological symptom
definition: Dizziness is a neurological and physiological symptom characterized by a sensation of unsteadiness accompanied by a feeling of movement within the head.
imported from: symp.owl
database cross reference: ICD9CM_2005:780.4
database cross reference: UMLS_CUI:C0476206
database cross reference: UMLS_ICD9CM_2005_AUI:A0243727
has exact synonym: dizzy
has_obo_namespace: symptoms
id: SYMP:0000610

renal failure
type: Class
subclass of: urinary system symptom
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0000731

stroke
type: Class
subclass of: nervous system symptom
subclass of: Restriction
  on property: isRiskFactorFor
  some values from: Alzheimer's disease
definition: Stroke is a nervous system symptom characterized by a sudden diminution or loss of consciousness, sensation, and voluntary motion caused by rupture or obstruction (as by a clot) of a blood vessel of the brain.
imported from: symp.owl
has exact synonym: apoplexy
has exact synonym: brain attack
has exact synonym: cerebral accident
has exact synonym: cerebrovascular accident
has_obo_namespace: symptoms
id: SYMP:0000734

constipation
type: Class
subclass of: digestive system symptom
definition: Constipation is a feces and droppings symptom involving the abnormally delayed or infrequent passage of dry hardened feces.
imported from: symp.owl
has_obo_namespace: symptoms
id: SYMP:0019180
comment: doid/symp duplicate

behavioral symptom
type: Class
subclass of: nervous system symptom
definition: A nervous system symptom that involves, is related to, or emphasizes behavior.
imported from: symp.owl

function-related process
type: Class
subclass of: primitive process
definition: Function-related process is a process that related to the execution of a function, a metafunction, and the malfunction.
imported from: txpo.owl
database cross reference: FBRL: A Function and Behavior Representation Language. Sasajima, M., Kitamura, Y., Ikeda, M. & Mizoguchi, R., In Proc. of IJCAI-95 (pp. 1830-1836), 1995
database cross reference: doi:10.1115/DETC2006-9913
database cross reference: https://doi.org/10.1016/S1474-0346(02)00006-X
comment: This tree is based on a functional concept ontology (Kitamura 2002).

primitive process
type: Class
subclass of: process
definition: Primitive process is a unit of process. Process series at a certain granular level can appear as one primitive process at the higher level.
imported from: txpo.owl
comment: Whether the process is a primitive process or not depends on the setting of the granularity. When one does not consider the details more than a certain level, or a level as the minimum grain size, the process at that level becomes the primitive process.

ion channel
type: Class
subclass of: transporter
definition: A role played by the entity which enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).
imported from: txpo.owl
comment: related molecular function GO:0005216

functioning process
type: Class
subclass of: function-related process
definition: Functioning process is a subtype of function-related process: A process that executes and manifests function.
imported from: txpo.owl

malfunctioning process
type: Class
subclass of: function-related process
definition: Malfunctioning process is a subtype of function-related process: A process that cannot perform a function appropriately or cannot realize it at all.
imported from: txpo.owl

dysfunctioning
type: Class
subclass of: malfunctioning process
definition: Dysfunctioning is a subtype of malfunctioning process: A process that performs an abnormal and incomplete functioning.
imported from: txpo.owl

starvation
type: Class
subclass of: functioning process
definition: Starvation is a subtype of depleting: A process that lessens markedly in quantity of the nourishment.
imported from: txpo.owl
database cross reference: http://purl.bioontology.org/ontology/MESH/D013217

protein kinase
type: Class
subclass of: enzyme
definition: Catalysis role of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
imported from: txpo.owl
database cross reference: rerlated molecular fuction GO:0004672

mitochondrial dysfunction
type: Class
subclass of: dysfunctioning
definition: Mitochondrial dysfunction is a subtype of dysfunctioning: A process that performs an abnormal and incomplete mitochondrial function.
imported from: txpo.owl

protein aggregation
type: Class
subclass of: functioning process
definition: Protein aggregation is a subtype of molecular assembly: The aggregation, arrangement and bonding together of molecules.
imported from: txpo.owl
database cross reference: http://jglobal.jst.go.jp/en/detail
database cross reference: http://purl.jp/bio/4/id/200906073816740790

ceramidase
type: Class
subclass of: enzyme
definition: Catalysis role of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine.
imported from: txpo.owl

transporter
type: Class
subclass of: functional role
definition: A role which enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
imported from: txpo.owl
comment: related molecular function GO:0005215

transcription factor
type: Class
subclass of: functional role
definition: A role played by the entity to initiate or regulate transcription.
imported from: txpo.owl
database cross reference: IMR:0000368 (obsolete)
comment: This term is sometimes used for both gene regulatory proteins as well as the general transcription factors.

potassium channel
type: Class
subclass of: ion channel
definition: A role played by the entity which enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
imported from: txpo.owl
comment: related molecular function GO:0005267

GTPase
type: Class
subclass of: enzyme
definition: Catalysis role of the reaction: GTP + H2O = GDP + phosphate.
imported from: txpo.owl
database cross reference: EC:3.6.5.-
database cross reference: IMR:0000960 (obsolete)
comment: related moleular function: GO:0003924

histone deacetylase
type: Class
subclass of: enzyme
definition: Catalysis role of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
imported from: txpo.owl
database cross reference: IMR:0001166 (obsolete)
database cross reference: related molecule fuction GO:0004407
has exact synonym: HDAC

phospholipase
type: Class
subclass of: chemical role
imported from: txpo.owl
database cross reference: Catalysis role of the hydrolysis of a glycerophospholipid.
database cross reference: EC:3.1.1
database cross reference: IMR:0000281 (obsolete)
comment: related molecular fuction : GO:0004620

phosphatase
type: Class
subclass of: enzyme
definition: Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
imported from: txpo.owl
database cross reference: EC:3.1.3.
database cross reference: EC:3.1.3.41
database cross reference: IMR:0000517 (obsolete)
has exact synonym: phosphoric monoester hydrolase activity
has_narrow_synonym: NPPase activity
comment: related molecular function GO:0016791

ligand-gated ion channel
type: Class
subclass of: ion channel
definition: A role played by the entity which enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
imported from: txpo.owl
comment: related molecular function GO:0015276

functional role
type: Class
subclass of: role
definition: A role played by the entity of funtion as realizable entity.
imported from: txpo.owl

protein ubiquitination
type: Class
subclass of: functioning process
definition: The process in which one or more ubiquitin groups are added to a protein.
imported from: txpo.owl
has exact synonym: protein ubiquitinylation
has exact synonym: protein ubiquitylation

ceramide acumulation
type: Class
subclass of: functioning process
definition: ceramide accumulation is a subtype of accumulation of substances in a biological object: A process that keeps ceramide in an organism, tissue, organelle, or cell.
imported from: txpo.owl

GPCR
type: Class
subclass of: receptor
imported from: txpo.owl
has exact synonym: G protein-coupled receptors

niacin
type: Class
subclass of: object
imported from: txpo.owl

ganglion
type: Class
subclass of: cell cluster organ
definition: A biological tissue mass, most commonly a mass of nerve cell bodies.
editor note: TODO - check vert vs invert. Other species: Any of a number of aggregations of neurons, glial cells and their processes, surrounded by a glial cell and connective tissue sheath (plural: ganglia). // Subdivision of neural tree (organ) which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord); together with a nucleus and its associated nerve, it constitutes a neural tree (organ). Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion. // a cluster of nerve cells and associated glial cells (nuclear location) // Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.
imported from: uberon.owl
external_definition: A ganglion is a cluster of neurons. It is part of a nervous system. It may include glial cells. The neurons are arranged in a specific constellation: neuronal somata are concentrated at the surface, thus forming a cell cortex, and neurites are concentrated in the centre of the ganglion to form the neuropil. A ganglion is a distinct unit but several ganglia may be anterio-posteriorly joined by connectives or transversally by commissures
external_definition: Portion of tissue that contains cell bodies of neurons and is located outside the central nervous system.[AAO]
external_definition: Structures containing a collection of nerve cell bodies. (Source: BioGlossary, www.Biology-Text.com)[TAO]
external_definition: Subdivision of nervous system which primarily consists of cell bodies of neurons located outside the neuraxis (brain and spinal cord. Examples: spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion (adapted from Foundational Model of Anatomy)[NLXANAT:100302].
homology_notes: Cranial sensory placodes are focused areas of the head ectoderm of vertebrates that contribute to the development of the cranial sense organs and their associated ganglia. Placodes have long been considered a key character of vertebrates, and their evolution is proposed to have been essential for the evolution of an active predatory lifestyle by early vertebrates.[well established][VHOG]
has_relational_adjective: ganglionic
contributor: cmungall
database cross reference: Ganglion
database cross reference: http://linkedlifedata.com/resource/umls/id/C0017067
database cross reference: AAO:0010426
database cross reference: AEO:0000135
database cross reference: BAMS:G
database cross reference: BTO:0000497
database cross reference: CALOHA:TS-0397
database cross reference: EFO:0000899
database cross reference: EHDAA2:0003135
database cross reference: EHDAA:2897
database cross reference: EHDAA:4662
database cross reference: EHDAA:5621
database cross reference: EHDAA:918
database cross reference: EMAPA:32846
database cross reference: EV:0100372
database cross reference: FBbt:00005137
database cross reference: FMA:5884
database cross reference: MA:0002406
database cross reference: MAT:0000207
database cross reference: MAT:0000343
database cross reference: MESH:D005724
database cross reference: MIAA:0000207
database cross reference: MIAA:0000343
database cross reference: NCIT:C12719
database cross reference: NLXANAT:100302
database cross reference: TAO:0000190
database cross reference: TGMA:0001016
database cross reference: UMLS:C0017067
database cross reference: VHOG:0000156
database cross reference: WBbt:0005189
database cross reference: XAO:0000209
database cross reference: ZFA:0000190
has_obo_namespace: uberon
has_related_synonym: ganglia
has_related_synonym: neural ganglion
id: UBERON:0000045
in subset: efo slim
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

anatomical structure
type: Class
subclass of: material anatomical entity
definition: Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.
imported from: uberon.owl
database cross reference: AnatomicalStructure
database cross reference: http://www.snomedbrowser.com/Codes/Details/362889002
database cross reference: AAO:0010825
database cross reference: AEO:0000003
database cross reference: BILA:0000003
database cross reference: CARO:0000003
database cross reference: EHDAA2:0003003
database cross reference: EMAPA:0
database cross reference: FBbt:00007001
database cross reference: FMA:305751
database cross reference: FMA:67135
database cross reference: GAID:781
database cross reference: HAO:0000003
database cross reference: MA:0003000
database cross reference: MESH:D000825
database cross reference: TAO:0000037
database cross reference: TGMA:0001823
database cross reference: VHOG:0001759
database cross reference: XAO:0003000
database cross reference: ZFA:0000037
has exact synonym: biological structure
has exact synonym: connected biological structure
has_obo_namespace: uberon
id: UBERON:0000061
in subset: upper level

organ
type: Class
subclass of: multicellular anatomical structure
definition: Anatomical structure that performs a specific function or group of functions [WP].
imported from: uberon.owl
never in taxon: NCBITaxon_110815
external_definition: Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
external_ontology_notes: CARO v1 does not include a generic 'organ' class, only simple and compound organ. CARO v2 may include organ, see https://github.com/obophenotype/caro/issues/4
database cross reference: Organ (anatomy)
database cross reference: http://linkedlifedata.com/resource/umls/id/C0178784
database cross reference: http://www.snomedbrowser.com/Codes/Details/272625005
database cross reference: BIRNLEX:4
database cross reference: CARO:0020004
database cross reference: EFO:0000634
database cross reference: EMAPA:35949
database cross reference: ENVO:01000162
database cross reference: FMA:67498
database cross reference: MA:0003001
database cross reference: NCIT:C13018
database cross reference: OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA
database cross reference: OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA
database cross reference: UMLS:C0178784
database cross reference: WBbt:0003760
has_obo_namespace: uberon
has_related_synonym: anatomical unit
has_related_synonym: body organ
has_related_synonym: element
id: UBERON:0000062
in subset: upper level

organ part
type: Class
subclass of: multicellular anatomical structure
definition: A multicellular structure that is a part of an organ.
curator note: currently defined in a very broad sense, may be replaced by more specific classes in the future
imported from: uberon.owl
database cross reference: http://www.snomedbrowser.com/Codes/Details/113343008
database cross reference: http://www.snomedbrowser.com/Codes/Details/91717005
database cross reference: AAO:0011124
database cross reference: BIRNLEX:16
database cross reference: EFO:0000635
database cross reference: FMA:82472
has exact synonym: cardinal organ part
has_obo_namespace: uberon
has_related_synonym: regional part of organ
id: UBERON:0000064
in subset: efo slim
in subset: non informative
in subset: upper level

regional part of nervous system
type: Class
subclass of: multi-tissue structure
definition: Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS.
imported from: uberon.owl
contributor: https://orcid.org/0000-0001-9114-8737
created by: Melissa Haendel
creation date: 2009-06-18T09:00:04Z
database cross reference: http://linkedlifedata.com/resource/umls/id/C1518256
database cross reference: http://www.snomedbrowser.com/Codes/Details/25087005
database cross reference: BIRNLEX:1157
database cross reference: NCIT:C13040
database cross reference: UMLS:C1518256
has exact synonym: part of nervous system
has_obo_namespace: uberon
id: UBERON:0000073
in subset: non informative
in subset: upper level

blood brain barrier
type: Class
subclass of: anatomical structure
definition: Cell layer consisting of lining cells that separates the central nervous system and the bloodstream. The BBB may consist of endothelial cells or glial cells. An endothelial barrier may have arisen independently several times during evolution. In bichir and lungfish the barrier is formed by brain endothelial cells, while in sturgeon it is formed by a complex perivascular glial sheath, but with no detectable tight junctions.
imported from: uberon.owl
database cross reference: Blood-brain barrier
database cross reference: http://linkedlifedata.com/resource/umls/id/C0005854
database cross reference: nlx subcell 100205
database cross reference: NCIT:C13194
database cross reference: UMLS:C0005854
has exact synonym: blood-brain barrier
has_obo_namespace: uberon
has_related_synonym: BBB
id: UBERON:0000120

neuron projection bundle
type: Class
subclass of: multi cell part structure
definition: A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.
imported from: uberon.owl
has_alternative_id: UBERON:0005163
database cross reference: CARO:0001001
database cross reference: FBbt:00005099
database cross reference: NLX:147821
has exact synonym: funiculus
has exact synonym: nerve fiber bundle
has exact synonym: neural fiber bundle
has_obo_namespace: uberon
id: UBERON:0000122

neural nucleus
type: Class
subclass of: central nervous system cell part cluster
definition: A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO)
definition: A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO).
imported from: uberon.owl
external_definition: Anatomical structure consisting of a discrete aggregate of neuronal soma[GO][GO_REF:0000021].
external_ontology_notes: Proposed CUMBO def from MM: A subcortical part of the nervous system consisting of a relatively compact group of cells that is distinguishable histologically that share a commonality of cytoarchitecture, chemoarchitecturel and connectivity. (comments: I put in 'subcortical' because I don't think we consider either the cerebellar cortex or cerebral cortex to be nuclei. Some people distinguish between a nucleus and a laminar structure (see Wikipedia definition). However, there are structures identified as nuclei that are laminar, e.g., lateral geniculate nucleus, although they are not laminated in all species. Also, I put in 'relatively compact' and 'distiguishable by histology' because we have groups of cells, e.g., cholinergic cell groups, doparminergic cell groups that are related on the 3 criteria but which we don't tend to consider nuclei because they don't occupy an easily defined territory. But all is open to debate.
has_broad_synonym: nucleus
database cross reference: Nucleus (neuroanatomy)
database cross reference: AEO:0000136
database cross reference: FMA:83686
database cross reference: NCIT:C13197
database cross reference: NLX:28443
has exact synonym: nervous system nucleus
has exact synonym: neuraxis nucleus
has exact synonym: neuronal nucleus
has exact synonym: nucleus of CNS
has_obo_namespace: uberon
has_related_synonym: nucleus of neuraxis
id: UBERON:0000125
in subset: cumbo

blood
type: Class
subclass of: anatomical structure
definition: A fluid that is composed of blood plasma and erythrocytes.
curator note: This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid.
imported from: uberon.owl
external_definition: A complex mixture of cells suspended in a liquid matrix that delivers nutrients to cells and removes wastes. (Source: BioGlossary, www.Biology-Text.com)[TAO]
external_definition: Highly specialized circulating tissue consisting of several types of cells suspended in a fluid medium known as plasma.[AAO]
axiom_lost_from_external_ontology: relationship loss: subclass specialized connective tissue (AAO:0000571)[AAO]
homology_notes: Recent findings strongly suggest that the molecular pathways involved in the development and function of blood cells are highly conserved among vertebrates and various invertebrates phyla. (...) There is now good reason to believe that, in vertebrates and invertebrates alike, blood cell lineages diverge from a common type of progenitor cell, the hemocytoblast.[well established][VHOG]
contributor: cmungall
contributor: tmeehan
database cross reference: Blood
database cross reference: http://linkedlifedata.com/resource/umls/id/C0005767
database cross reference: AAO:0000046
database cross reference: BTO:0000089
database cross reference: CALOHA:TS-0079
database cross reference: EFO:0000296
database cross reference: EHDAA2:0000176
database cross reference: EHDAA:418
database cross reference: EMAPA:16332
database cross reference: ENVO:02000027
database cross reference: EV:0100047
database cross reference: FMA:9670
database cross reference: GAID:965
database cross reference: MA:0000059
database cross reference: MESH:D001769
database cross reference: MIAA:0000315
database cross reference: NCIT:C12434
database cross reference: OpenCyc:Mx4rvVjI8JwpEbGdrcN5Y29ycA
database cross reference: TAO:0000007
database cross reference: UMLS:C0005767
database cross reference: VHOG:0000224
database cross reference: XAO:0000124
database cross reference: ZFA:0000007
database cross reference: galen:Blood
has exact synonym: portion of blood
has exact synonym: vertebrate blood
has_obo_namespace: uberon
has_related_synonym: whole blood
id: UBERON:0000178
in subset: efo slim
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

gyrus
type: Class
subclass of: ectoderm-derived structure
subclass of: structure with developmental contribution from neural crest
subclass of: morphological feature
definition: A ridge on the cerebral cortex. It is generally surrounded by one or more sulci .
imported from: uberon.owl
dubious_for_taxon: NCBITaxon_10088
fma_set_term: FMA_72015
contributor: RDruzinsky
contributor: cmungall
contributor: wdahdul
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Gyrus
database cross reference: http://linkedlifedata.com/resource/umls/id/C0458308
database cross reference: http://www.snomedbrowser.com/Codes/Details/279165009
database cross reference: BTO:0002495
database cross reference: FMA:83874
database cross reference: NCIT:C32290
database cross reference: UMLS:C0458308
has exact synonym: cerebral gyrus
has exact synonym: gyrus of neuraxis
has exact synonym: neuraxis gyrus
has_obo_namespace: uberon
has_related_synonym: folia
has_related_synonym: folium
has_related_synonym: folium of brain
has_related_synonym: gyri
has_related_synonym: gyri of cerebrum
has_related_synonym: gyrus of cerebral hemisphere
has_related_synonym: gyrus of cerebrum
id: UBERON:0000200
in subset: pheno slim

parenchyma
type: Class
subclass of: anatomical structure
definition: functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues.
imported from: uberon.owl
has_relational_adjective: parenchymal
development_notes: Early in development the mammalian embryo has three distinct layers: ectoderm (external layer), endoderm (internal layer) and in between those two layers the middle layer or mesoderm. The parenchyma of most organs is of ectodermal (brain, skin) or endodermal origin (lungs, gastrointestinal tract, liver, pancreas). The parenchyma of a few organs (spleen, kidneys, heart) is of mesodermal origin. The stroma of all organs is of mesodermal origin
external_ontology_notes: the FMA definition is more restrictive, and limits this to solid organs. This would seem to cause problems for the lung parenchyma, except FMA classifies Lung as solid rather than cavitated
database cross reference: Parenchyma
database cross reference: http://linkedlifedata.com/resource/umls/id/C0933845
database cross reference: EHDAA:3015
database cross reference: EHDAA:3905
database cross reference: EHDAA:3999
database cross reference: EHDAA:4005
database cross reference: EHDAA:6899
database cross reference: EHDAA:6903
database cross reference: EHDAA:6994
database cross reference: EHDAA:8086
database cross reference: EHDAA:9182
database cross reference: EHDAA:9190
database cross reference: EHDAA:9196
database cross reference: EHDAA:9202
database cross reference: FMA:45732
database cross reference: NCIT:C74601
database cross reference: UMLS:C0933845
has_obo_namespace: uberon
id: UBERON:0000353

prefrontal cortex
type: Class
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: The anterior part of the frontal lobes of the brain, lying in front of the motor and premotor areas.nnThis brain region has been implicated in planning complex cognitive behaviors, personality expression, decision making and moderating correct social behavior. The basic activity of this brain region is considered to be orchestration of thoughts and actions in accordance with internal goals.nnThe most typical psychological term for functions carried out by the pre-frontal cortex area is executive function. Executive function relates to abilities to differentiate among conflicting thoughts, determine good and bad, better and best, same and different, future consequences of current activities, working toward a defined goal, prediction of outcomes, expectation based on actions, and social 'control' (the ability to suppress urges that, if not suppressed, could lead to socially-unacceptable outcomes).nnMany authors have indicated an integral link between a person's personality and the functions of the prefrontal cortex. - definition adapted from Wikipedia.
editor note: TODO - check MA
imported from: uberon.owl
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Prefrontal cortex
database cross reference: BAMS:FrA
database cross reference: BTO:0002807
database cross reference: DHBA:10172
database cross reference: EFO:0001384
database cross reference: EMAPA:35356
database cross reference: FMA:224850
database cross reference: GAID:676
database cross reference: MA:0000906
database cross reference: MESH:A08.186.211.730.885.213.270.700
database cross reference: NLXANAT:090801
has exact synonym: prefrontal association cortex
has_obo_namespace: uberon
has_related_synonym: frontal association cortex
has_related_synonym: prefrontal association complex
id: UBERON:0000451
in subset: efo slim

organism substance
type: Class
subclass of: material anatomical entity
definition: Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.
imported from: uberon.owl
database cross reference: AAO:0010839
database cross reference: AEO:0000004
database cross reference: BILA:0000004
database cross reference: CALOHA:TS-2101
database cross reference: CARO:0000004
database cross reference: EHDAA2:0003004
database cross reference: EMAPA:35178
database cross reference: FBbt:00007019
database cross reference: FMA:9669
database cross reference: HAO:0000004
database cross reference: MA:0002450
database cross reference: NCIT:C13236
database cross reference: SPD:0000008
database cross reference: TAO:0001487
database cross reference: TGMA:0001824
database cross reference: VHOG:0001726
database cross reference: XAO:0004001
database cross reference: ZFA:0001487
database cross reference: galen:BodySubstance
has exact synonym: body fluid or substance
has exact synonym: body substance
has exact synonym: organism substance
has exact synonym: portion of body substance
has exact synonym: portion of organism substance
has_obo_namespace: uberon
id: UBERON:0000463
in subset: pheno slim
in subset: upper level

anatomical space
type: Class
subclass of: immaterial anatomical entity
definition: Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures.
imported from: uberon.owl
has_broad_synonym: lumen
has_broad_synonym: space
database cross reference: http://linkedlifedata.com/resource/umls/id/C0524461
database cross reference: AAO:0010110
database cross reference: AEO:0000005
database cross reference: BILA:0000005
database cross reference: CARO:0000005
database cross reference: EHDAA2:0003005
database cross reference: FBbt:00007017
database cross reference: FMA:5897
database cross reference: HAO:0000005
database cross reference: NCIT:C94478
database cross reference: TAO:0001668
database cross reference: TGMA:0001825
database cross reference: UMLS:C0524461
database cross reference: VHOG:0001728
database cross reference: XAO:0003190
database cross reference: ZFA:0001643
has exact synonym: lumen space
has_obo_namespace: uberon
has_related_synonym: anatomical spaces
id: UBERON:0000464
in subset: upper level

material anatomical entity
type: Class
subclass of: material entity
subclass of: anatomical entity
definition: Anatomical entity that has mass.
imported from: uberon.owl
database cross reference: AAO:0010264
database cross reference: AEO:0000006
database cross reference: BILA:0000006
database cross reference: CARO:0000006
database cross reference: EHDAA2:0003006
database cross reference: FBbt:00007016
database cross reference: FMA:67165
database cross reference: HAO:0000006
database cross reference: TAO:0001836
database cross reference: TGMA:0001826
database cross reference: VHOG:0001721
has_obo_namespace: uberon
id: UBERON:0000465
in subset: upper level

immaterial anatomical entity
type: Class
subclass of: anatomical entity
definition: Anatomical entity that has no mass.
imported from: uberon.owl
database cross reference: AAO:0010265
database cross reference: AEO:0000007
database cross reference: BILA:0000007
database cross reference: CARO:0000007
database cross reference: EHDAA2:0003007
database cross reference: FBbt:00007015
database cross reference: FMA:67112
database cross reference: HAO:0000007
database cross reference: TAO:0001835
database cross reference: TGMA:0001827
database cross reference: VHOG:0001727
has exact synonym: immaterial physical anatomical entity
has_obo_namespace: uberon
id: UBERON:0000466
in subset: upper level

anatomical cluster
type: Class
subclass of: anatomical entity
definition: Anatomical group that has its parts adjacent to one another.
editor note: Will be obsoleted in CARO v2 [https://github.com/obophenotype/caro/issues/3]
imported from: uberon.owl
database cross reference: AAO:0010009
database cross reference: AEO:0000041
database cross reference: BILA:0000041
database cross reference: CARO:0000041
database cross reference: EHDAA2:0003041
database cross reference: FBbt:00007277
database cross reference: FMA:49443
database cross reference: HAO:0000041
database cross reference: TADS:0000605
database cross reference: TAO:0001478
database cross reference: TGMA:0001842
database cross reference: VHOG:0001737
database cross reference: XAO:0003160
database cross reference: ZFA:0001478
has_obo_namespace: uberon
id: UBERON:0000477
in subset: upper level

tissue
type: Class
subclass of: multicellular anatomical structure
definition: Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation.
editor note: changed label and definition to reflect CARO2
imported from: uberon.owl
database cross reference: http://linkedlifedata.com/resource/umls/id/C0040300
database cross reference: AAO:0000607
database cross reference: AAO:0010054
database cross reference: AEO:0000043
database cross reference: BILA:0000043
database cross reference: BIRNLEX:19
database cross reference: CALOHA:TS-2090
database cross reference: CARO:0000043
database cross reference: EHDAA2:0003043
database cross reference: EMAPA:35868
database cross reference: FBbt:00007003
database cross reference: FMA:9637
database cross reference: HAO:0000043
database cross reference: MA:0003002
database cross reference: MESH:D014024
database cross reference: NCIT:C12801
database cross reference: TAO:0001477
database cross reference: TGMA:0001844
database cross reference: UMLS:C0040300
database cross reference: VHOG:0001757
database cross reference: WBbt:0005729
database cross reference: XAO:0003040
database cross reference: ZFA:0001477
database cross reference: galen:Tissue
has exact synonym: portion of tissue
has exact synonym: tissue portion
has_narrow_synonym: simple tissue
has_obo_namespace: uberon
id: UBERON:0000479
in subset: pheno slim
in subset: upper level

multi-tissue structure
type: Class
subclass of: multicellular anatomical structure
definition: Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types.
imported from: uberon.owl
database cross reference: AAO:0010048
database cross reference: AEO:0000055
database cross reference: BILA:0000055
database cross reference: CARO:0000055
database cross reference: EHDAA2:0003055
database cross reference: FBbt:00007010
database cross reference: HAO:0000055
database cross reference: TAO:0001488
database cross reference: TGMA:0001847
database cross reference: VHOG:0001762
database cross reference: XAO:0003037
database cross reference: ZFA:0001488
has_obo_namespace: uberon
has_related_synonym: multi-tissue structures
id: UBERON:0000481
in subset: upper level

epithelium
type: Class
subclass of: tissue
definition: Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO].
imported from: uberon.owl
homology_notes: The two basic types of metazoan tissue are epithelial and connective. The simplest metazoans, and developmental stages of many primitive invertebrates, consist solely of these two layers. Thus, epithelial and connective tissues may be the primary (original) tissues of metazoans, and both are important in the functional organization of animals.[well established][VHOG]
has_relational_adjective: epithelial
database cross reference: Epithelium
database cross reference: http://linkedlifedata.com/resource/umls/id/C0014609
database cross reference: http://www.snomedbrowser.com/Codes/Details/31610004
database cross reference: AAO:0000144
database cross reference: AAO:0010055
database cross reference: AEO:0000066
database cross reference: BILA:0000066
database cross reference: BTO:0000416
database cross reference: CALOHA:TS-0288
database cross reference: CARO:0000066
database cross reference: EHDAA2:0003066
database cross reference: EMAPA:32738
database cross reference: FBbt:00007005
database cross reference: FMA:9639
database cross reference: GAID:402
database cross reference: HAO:0000066
database cross reference: MA:0003060
database cross reference: MESH:D004848
database cross reference: NCIT:C12710
database cross reference: TAO:0001486
database cross reference: UMLS:C0014609
database cross reference: VHOG:0000387
database cross reference: XAO:0003045
database cross reference: ZFA:0001486
has exact synonym: epithelial tissue
has exact synonym: portion of epithelium
has_obo_namespace: uberon
id: UBERON:0000483
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core
comment: Editor note: surface epithelium may contain non-epithelial cells, such as melanocytes, lymphocytes and dendritic cells, within the sheet of epithelial cells. Do we consider these part of the epithelium, or located-in it?

simple squamous epithelium
type: Class
subclass of: unilaminar epithelium
subclass of: squamous epithelium
definition: Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA].
imported from: uberon.owl
external_definition: Unilaminar epithelium that consists of a single layer of squamous cells.[CARO]
database cross reference: Simple squamous epithelium
database cross reference: http://linkedlifedata.com/resource/umls/id/C0836133
database cross reference: AAO:0010066
database cross reference: AEO:0000070
database cross reference: BILA:0000070
database cross reference: BTO:0002073
database cross reference: CARO:0000070
database cross reference: EHDAA2:0003070
database cross reference: FMA:45565
database cross reference: HAO:0000070
database cross reference: NCIT:C13178
database cross reference: TAO:0001498
database cross reference: UMLS:C0836133
database cross reference: XAO:0004010
database cross reference: ZFA:0001498
has exact synonym: epithelium simplex squamosum
has_obo_namespace: uberon
has_related_synonym: simple squamous epithelia
id: UBERON:0000487
in subset: uberon slim
in subset: vertebrate core

cavitated compound organ
type: Class
subclass of: compound organ
definition: Compound organ that contains one or more macroscopic anatomical spaces.
curator note: this class was introduced for consistency with CARO, however, it has yet to be used in this or other ontologies. It may be retired in the future
imported from: uberon.owl
database cross reference: AAO:0010016
database cross reference: AEO:0000072
database cross reference: BILA:0000072
database cross reference: CARO:0000072
database cross reference: EHDAA2:0003072
database cross reference: FMA:55671
database cross reference: HAO:0000072
database cross reference: TAO:0001490
database cross reference: TGMA:0001857
database cross reference: VHOG:0001730
database cross reference: XAO:0003165
database cross reference: ZFA:0001490
has exact synonym: cavitated organ
has_obo_namespace: uberon
has_related_synonym: cavitated compound organs
id: UBERON:0000489
in subset: organ slim
in subset: upper level

unilaminar epithelium
type: Class
subclass of: epithelium
definition: Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA].
editor note: consider adding disjointness axiom between unilaminar and multilaminar - but note that this will render EHDAA2:0003244 (chorionic trophoblast) unsatisfiable
imported from: uberon.owl
external_definition: Epithelium that consists of a single layer of epithelial cells.[CARO]
database cross reference: http://linkedlifedata.com/resource/umls/id/C0682574
database cross reference: http://www.snomedbrowser.com/Codes/Details/309043004
database cross reference: AAO:0010062
database cross reference: AEO:0000073
database cross reference: BILA:0000073
database cross reference: BTO:0002073
database cross reference: CARO:0000073
database cross reference: EHDAA2:0003073
database cross reference: FMA:45561
database cross reference: HAO:0000073
database cross reference: NCIT:C33554
database cross reference: TAO:0001495
database cross reference: UMLS:C0682574
database cross reference: XAO:0004007
database cross reference: ZFA:0001495
has exact synonym: simple epithelium
has_obo_namespace: uberon
has_related_synonym: unilaminar epithelia
id: UBERON:0000490
in subset: vertebrate core

brain
type: Class
subclass of: organ
subclass of: ectoderm-derived structure
definition: The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].
editor note: requires review for applicability to invertebrate structures, e.g. synganglion
imported from: uberon.owl
external_definition: Cavitated compound organ which is comprised of gray and white matter and surrounds the cerebral ventricular system.[TAO]
external_definition: Part of the central nervous system situated within the cranium and composed of both nerve cell bodies and nerve fibers.[AAO]
external_definition: The part of the central nervous system contained within the cranium, comprising the forebrain, midbrain, hindbrain, and metencephalon. It is derived from the anterior part of the embryonic neural tube (or the encephalon). Does not include retina. (CUMBO)
homology_notes: (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]
contributor: cmungall
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Brain
database cross reference: http://linkedlifedata.com/resource/umls/id/C0006104
database cross reference: http://linkedlifedata.com/resource/umls/id/C1269537
database cross reference: http://www.snomedbrowser.com/Codes/Details/258335003
database cross reference: AAO:0010478
database cross reference: ABA:Brain
database cross reference: BAMS:Br
database cross reference: BAMS:Brain
database cross reference: BILA:0000135
database cross reference: BIRNLEX:796
database cross reference: BTO:0000142
database cross reference: CALOHA:TS-0095
database cross reference: DHBA:10155
database cross reference: EFO:0000302
database cross reference: EHDAA2:0000183
database cross reference: EHDAA:2641
database cross reference: EHDAA:6485
database cross reference: EMAPA:16894
database cross reference: EV:0100164
database cross reference: FBbt:00005095
database cross reference: FMA:50801
database cross reference: GAID:571
database cross reference: HBA:4005
database cross reference: MA:0000168
database cross reference: MAT:0000098
database cross reference: MBA:8
database cross reference: MBA:997
database cross reference: MESH:D001921
database cross reference: MIAA:0000098
database cross reference: NCIT:C12439
database cross reference: OpenCyc:Mx4rvVjT65wpEbGdrcN5Y29ycA
database cross reference: PBA:3999
database cross reference: TAO:0000008
database cross reference: UMLS:C0006104
database cross reference: UMLS:C1269537
database cross reference: VHOG:0000157
database cross reference: XAO:0000010
database cross reference: ZFA:0000008
database cross reference: galen:Brain
has_obo_namespace: uberon
has_related_synonym: encephalon
has_related_synonym: suprasegmental levels of nervous system
has_related_synonym: suprasegmental structures
has_related_synonym: synganglion
has_related_synonym: the brain
id: UBERON:0000955
in subset: cumbo
in subset: efo slim
in subset: major organ
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

cerebral cortex
type: Class
subclass of: central nervous system cell part cluster
subclass of: central nervous system gray matter layer
definition: The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex.
curator note: We follow NIFSTD in defining cerebral cortex and including both neocortex and hippocampal formation (DG+hippocampus).
imported from: uberon.owl
present in taxon: NCBITaxon_117569
external_definition: The cerebral cortex is a structure within the brain that plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It constitutes the outermost layer of the cerebrum. In preserved brains, it has a grey color, hence the name 'grey matter'. Grey matter is formed by neurons and their unmyelinated fibers, whereas the white matter below the grey matter of the cortex is formed predominantly by myelinated axons interconnecting different regions of the central nervous system. The human cerebral cortex is 2-4 mm (0.08-0.16 inches) thick. The surface of the cerebral cortex is folded in large mammals, such that more than two-thirds of the cortical surface is buried in the grooves, called 'sulci. ' The phylogenetically most recent part of the cerebral cortex, the neocortex, also called isocortex, is differentiated into six horizontal layers; the more ancient part of the cerebral cortex, the hippocampus (also called archicortex), has at most three cellular layers, and is divided into subfields. Relative variations in thickness or cell type (among other parameters) allow us to distinguish between different neocortical architectonic fields. The geometry of at least some of these fields seems to be related to the anatomy of the cortical folds, and, for example, layers in the upper part of the cortical ridges seem to be more clearly differentiated than in its deeper parts. [WP,unvetted][Wikipedia:Cerebral_cortex].
homology_notes: Migration of neurons from the basal or striatal portions of the anterior part of the neural tube occurs to varying degrees in different vertebrate classes, but a true cerebral cortex is generally acknowledged to have made its first appearance in reptiles. The definition can be unambiguous, since 'cortex' simply implies the existence of a surface neuronal layer with an overlying 'zonal lamina' or 'molecular' layer containing dendrites and axons, which is separated from the underlying basal 'matrix' by white matter. Although reptilian cerebral cortex does indeed fulfill these conditions in certain locations, the separation from striatal structures is often indistinct, so that it may even be argued that some primitive dipnoans possess a pallium or cortex. Nevertheless, an extensive laminated layer separated by underlying white matter is well represented only in reptiles and mammals.[well established][VHOG]
taxon_notes: hagfishes have independently evolved a highly laminated cerebral cortex, comparable in many ways to the cerebral cortex of mammals [http://icb.oxfordjournals.org/content/42/4/743]
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Cerebral cortex
database cross reference: http://linkedlifedata.com/resource/umls/id/C0007776
database cross reference: http://www.snomedbrowser.com/Codes/Details/362880003
database cross reference: BAMS:C
database cross reference: BAMS:CTX
database cross reference: BAMS:Cerebral_cortex
database cross reference: BAMS:Cx
database cross reference: BIRNLEX:1494
database cross reference: BM:Tel-Cx
database cross reference: BTO:0000233
database cross reference: CALOHA:TS-0091
database cross reference: DHBA:10159
database cross reference: EFO:0000328
database cross reference: EHDAA2:0000234
database cross reference: EHDAA:5464
database cross reference: EMAPA:17544
database cross reference: EV:0100166
database cross reference: FMA:61830
database cross reference: GAID:629
database cross reference: HBA:4008
database cross reference: MA:0000185
database cross reference: MAT:0000108
database cross reference: MBA:688
database cross reference: MESH:A08.186.211.730.885.213
database cross reference: MIAA:0000108
database cross reference: NCIT:C12443
database cross reference: PBA:128011354
database cross reference: UMLS:C0007776
database cross reference: VHOG:0000722
has exact synonym: cortex of cerebral hemisphere
has_obo_namespace: uberon
has_related_synonym: brain cortex
has_related_synonym: cortex cerebralis
has_related_synonym: cortex cerebri
has_related_synonym: cortical plate (CTXpl)
has_related_synonym: cortical plate (areas)
has_related_synonym: pallium of the brain
id: UBERON:0000956
in subset: efo slim
in subset: pheno slim
in subset: uberon slim

central nervous system
type: Class
subclass of: ectoderm-derived structure
subclass of: organ system subdivision
definition: The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
imported from: uberon.owl
never in taxon: NCBITaxon_147099
external_definition: Part of the nervous system which includes the brain and spinal cord.[AAO]
external_definition: The brain and spinal cord. Kimmel et al, 1995.[TAO]
external_definition: The central nervous system (CNS) is the part of the nervous system which includes the brain, spinal cord, and nerve cell layer of the retina (CUMBO).
homology_notes: (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2); Taken together, our data make a very strong case that the complex molecular mediolateral architecture of the developing trunk CNS (central nervous system), as shared between Platynereis and vertebrates, was already present in their last common ancestor, Urbilateria. The concept of bilaterian nervous system centralization implies that neuron types concentrate on one side of the trunk, as is the case in vertebrates and many invertebrates including Platynereis, where they segregate and become spatially organized (as opposed to a diffuse nerve net). Our data reveal that a large part of the spatial organization of the annelid and vertebrate CNS was already present in their last common ancestor, which implies that Urbilateria had already possessed a CNS (reference 3).[well established][VHOG]
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Central nervous system
database cross reference: http://linkedlifedata.com/resource/umls/id/C0927232
database cross reference: http://www.snomedbrowser.com/Codes/Details/278199004
database cross reference: AAO:0000090
database cross reference: BAMS:CNS
database cross reference: BILA:0000080
database cross reference: BIRNLEX:1099
database cross reference: BTO:0000227
database cross reference: CALOHA:TS-0150
database cross reference: EFO:0000908
database cross reference: EHDAA2:0000225
database cross reference: EHDAA:828
database cross reference: EMAPA:16470
database cross reference: EMAPA:16754
database cross reference: EV:0100163
database cross reference: FBbt:00005094
database cross reference: FMA:55675
database cross reference: GAID:570
database cross reference: MA:0000167
database cross reference: MAT:0000457
database cross reference: MESH:D002490
database cross reference: NCIT:C12438
database cross reference: OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA
database cross reference: TAO:0000012
database cross reference: UMLS:C0927232
database cross reference: VHOG:0000293
database cross reference: XAO:0000215
database cross reference: ZFA:0000012
has exact synonym: CNS
has exact synonym: systema nervosum centrale
has_narrow_synonym: cerebrospinal axis
has_obo_namespace: uberon
has_related_synonym: neuraxis
id: UBERON:0001017
in subset: cumbo
in subset: efo slim
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

axon tract
type: Class
subclass of: neuron projection bundle
subclass of: central nervous system cell part cluster
definition: A group of axons linking two or more neuropils and having a common origin, termination[FBbt].
imported from: uberon.owl
external_definition: White matter structure of CNS that contains axons that arise predominantly in one central nervous system part and terminate in another. Tracts are generally named by their region or origin followed by their region of primary termination, e.g., mammillothalamic tract contains axons that arise from neurons in the mammillary bodies and terminate in the thalamus. (CUMBO)
database cross reference: BIRNLEX:1649
database cross reference: EV:0100304
database cross reference: FBbt:00005100
database cross reference: FMA:83847
database cross reference: NLX:147822
has exact synonym: axonal tract
has exact synonym: neuraxis tract
has exact synonym: tract of neuraxis
has_narrow_synonym: nerve tract
has_obo_namespace: uberon
has_related_synonym: nerve tract
has_related_synonym: tract
id: UBERON:0001018
in subset: cumbo
in subset: pheno slim
comment: WP says this is the analog of peripheral nerves in CNS.

anatomical entity
type: Class
subclass of: independent continuant
subclass of: material entity
subclass of: Restriction
  on property: isAnatomicalEntityFor
  some values from: Alzheimer's disease
definition: Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.
imported from: uberon.owl
database cross reference: http://linkedlifedata.com/resource/umls/id/C1515976
database cross reference: AAO:0010841
database cross reference: AEO:0000000
database cross reference: BILA:0000000
database cross reference: BIRNLEX:6
database cross reference: CARO:0000000
database cross reference: EHDAA2:0002229
database cross reference: FBbt:10000000
database cross reference: FBbt_root:00000000
database cross reference: FMA:62955
database cross reference: HAO:0000000
database cross reference: MA:0000001
database cross reference: NCIT:C12219
database cross reference: TAO:0100000
database cross reference: TGMA:0001822
database cross reference: UMLS:C1515976
database cross reference: WBbt:0000100
database cross reference: XAO:0000000
database cross reference: ZFA:0100000
has_obo_namespace: uberon
id: UBERON:0001062
in subset: upper level

intestinal epithelium
type: Class
subclass of: anatomical structure
definition: Epithelial layer that lines the intestine.
imported from: uberon.owl
external_definition: Simple columnar epithelium that lines the intestine, sometimes pseudostratified, with absorptive brush-border cells and mucous goblet cells clearly visible. Crosnier et al. 2005[TAO]
database cross reference: Intestinal epithelium
database cross reference: http://linkedlifedata.com/resource/umls/id/C0226890
database cross reference: http://www.snomedbrowser.com/Codes/Details/266135004
database cross reference: BTO:0000781
database cross reference: EMAPA:32873
database cross reference: FMA:17229
database cross reference: MA:0001536
database cross reference: NCIT:C49240
database cross reference: TAO:0005124
database cross reference: UMLS:C0226890
database cross reference: ZFA:0005124
has exact synonym: bowel epithelial tissue
has exact synonym: bowel epithelium
has exact synonym: epithelial tissue of bowel
has exact synonym: epithelial tissue of intestine
has exact synonym: epithelium of bowel
has exact synonym: epithelium of intestine
has exact synonym: intestine epithelial tissue
has_narrow_synonym: villous epithelium
has_obo_namespace: uberon
has_related_synonym: intestine epithelium
id: UBERON:0001277
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

cerebrospinal fluid
type: Class
subclass of: transudate
subclass of: multicellular anatomical structure
definition: A clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord.
editor note: many sources state the CP as sole producer of CSF, but this is disputed [DOI:10.1007/s11064-015-1581-6]
imported from: uberon.owl
external_definition: Portion of organism substance that is a clear fluid that occupies the subarachnoid space and the ventricular system around and inside the brain.[TAO]
homology_notes: In vertebrates, at early stages of Central Nervous System (CNS) development, the architecture of the brain primordium reveals the presence of the cavity of brain vesicles, which is filled by Embryonic Cerebro-Spinal Fluid (E-CSF). (...) Rat and chick E-CSF proteomes are similar, although rat is more complex in certain groups of proteins, e.g., apolipoproteins, which may be involved in the control of neural diversity, and has soluble enzymes present, just like adult human CSF, but unlike chick E-CSF, revealing phylogenetic brain differences between these groups of vertebrates.[uncertain][VHOG]
external_ontology_notes: EHDAA2 models this as developing from CP, which is wrong
external_ontology_notes: the FMA def states that this is subarachnoid spaces only. ZFA def states subarachnoid spaces and brain ventricles, but not SC (and has part_of to brain). Circulation: It circulates from the lateral ventricles to the foramen of Monro (Interventricular foramen), third ventricle, aqueduct of Sylvius (Cerebral aqueduct), fourth ventricle, foramen of Magendie (Median aperture) and foramina of Luschka (Lateral apertures), subarachnoid space over brain and spinal cord. It should be noted that the CSF moves in a pulsatile manner throughout the CSF system with nearly zero net flow. CSF is reabsorbed into venous sinus blood via arachnoid granulations.
database cross reference: Cerebrospinal fluid
database cross reference: http://linkedlifedata.com/resource/umls/id/C0007806
database cross reference: BIRNLEX:1798
database cross reference: BTO:0000237
database cross reference: CALOHA:TS-0130
database cross reference: EFO:0000329
database cross reference: EHDAA2:0004441
database cross reference: ENVO:02000029
database cross reference: EV:0100311
database cross reference: FMA:20935
database cross reference: GAID:1181
database cross reference: MA:0002503
database cross reference: MAT:0000499
database cross reference: MESH:A12.207.268
database cross reference: NCIT:C12692
database cross reference: TAO:0002184
database cross reference: UMLS:C0007806
database cross reference: VHOG:0001278
database cross reference: ZFA:0001626
has exact synonym: CSF
has exact synonym: cerebral spinal fluid
has_obo_namespace: uberon
has_related_synonym: liquor cerebrospinalis
has_related_synonym: spinal fluid
id: UBERON:0001359
in subset: efo slim
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

cortex
type: Class
subclass of: organ part
definition: Outermost layer of an organ[WP].
imported from: uberon.owl
has_relational_adjective: cortical
external_ontology_notes: this class is used more generically than in FMA, and includes e.g. cortex of hair
database cross reference: Cortex (anatomy)
database cross reference: EFO:0000383
database cross reference: EHDAA:9344
database cross reference: FMA:61109
database cross reference: galen:Cortex
has exact synonym: cortex
has exact synonym: cortex of organ
has_obo_namespace: uberon
id: UBERON:0001851
in subset: pheno slim
in subset: uberon slim
in subset: upper level

cerebral hemisphere
type: Class
subclass of: organ part
subclass of: ectoderm-derived structure
subclass of: structure with developmental contribution from neural crest
subclass of: lateral structure
definition: One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA].
imported from: uberon.owl
external_definition: Part of the telencephalon consisting of either of the two smooth, elongated halves of the cerebrum.[AAO]
homology_notes: The presence of paired evaginated hemispheres and olfactory bulbs in both agnathan and gnathostome radiations suggests that such hemispheres were also present in the common ancestor.[well established][VHOG]
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Cerebral hemisphere
database cross reference: http://linkedlifedata.com/resource/umls/id/C0228174
database cross reference: http://linkedlifedata.com/resource/umls/id/C0242202
database cross reference: http://www.snomedbrowser.com/Codes/Details/278251007
database cross reference: AAO:0010480
database cross reference: BAMS:HEM
database cross reference: BIRNLEX:1042
database cross reference: BTO:0000231
database cross reference: CALOHA:TS-2007
database cross reference: DMBA:15739
database cross reference: EFO:0002521
database cross reference: EMAPA:16653
database cross reference: FMA:61817
database cross reference: MA:0000133
database cross reference: MBA:403
database cross reference: NCIT:C12351
database cross reference: OpenCyc:Mx4rvigx5ZwpEbGdrcN5Y29ycA
database cross reference: UMLS:C0228174
database cross reference: UMLS:C0242202
database cross reference: VHOG:0001639
database cross reference: galen:CerebralHemisphere
has_obo_namespace: uberon
has_related_synonym: cerebrum
has_related_synonym: hemisphere
has_related_synonym: hemispheric regions
has_related_synonym: hemispherium cerebri
has_related_synonym: medial amygdalar nucleus
has_related_synonym: nucleus amygdaloideus medialis
has_related_synonym: nucleus medialis amygdalae
id: UBERON:0001869
in subset: efo slim
in subset: pheno slim
in subset: uberon slim

temporal lobe
type: Class
subclass of: lobe of cerebral hemisphere
definition: Lower lateral part of the cerebral hemisphere. (MSH).
imported from: uberon.owl
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Temporal lobe
database cross reference: http://linkedlifedata.com/resource/umls/id/C0039485
database cross reference: http://linkedlifedata.com/resource/umls/id/C1268978
database cross reference: http://www.snomedbrowser.com/Codes/Details/180921000
database cross reference: BAMS:TL
database cross reference: BAMS:Temporal_lobe
database cross reference: BIRNLEX:1160
database cross reference: BTO:0001355
database cross reference: CALOHA:TS-1020
database cross reference: DHBA:12139
database cross reference: EFO:0000917
database cross reference: EMAPA:18797
database cross reference: EV:0100169
database cross reference: FMA:61825
database cross reference: GAID:635
database cross reference: HBA:4132
database cross reference: MAT:0000508
database cross reference: MESH:A08.186.211.730.885.213.863
database cross reference: NCIT:C12353
database cross reference: OpenCyc:Mx4rwQLi-ZwpEbGdrcN5Y29ycA
database cross reference: UMLS:C0039485
database cross reference: UMLS:C1268978
has exact synonym: lobus temporalis
has_narrow_synonym: temporal cortex
has_obo_namespace: uberon
id: UBERON:0001871
in subset: efo slim
in subset: pheno slim
in subset: uberon slim
comment: Boundary notes: It is bounded dorsally by the lateral fissure and posteriorly by an arbitrary border shared with the occipital lobe. [Wikipedia:Temporal_lobe]

parietal lobe
type: Class
subclass of: lobe of cerebral hemisphere
definition: Upper central part of the cerebral hemisphere. (MSH).
imported from: uberon.owl
has_broad_synonym: parietal region
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Parietal lobe
database cross reference: http://linkedlifedata.com/resource/umls/id/C0030560
database cross reference: http://www.snomedbrowser.com/Codes/Details/180922007
database cross reference: BAMS:Parietal_lobe
database cross reference: BIRNLEX:1148
database cross reference: BTO:0001001
database cross reference: CALOHA:TS-0747
database cross reference: DHBA:12131
database cross reference: EFO:0000914
database cross reference: EV:0100168
database cross reference: FMA:61826
database cross reference: GAID:680
database cross reference: HBA:4084
database cross reference: MAT:0000506
database cross reference: MESH:A08.186.211.730.885.213.670
database cross reference: NCIT:C12354
database cross reference: OpenCyc:Mx4rvg-typwpEbGdrcN5Y29ycA
database cross reference: UMLS:C0030560
has exact synonym: regio parietalis
has_obo_namespace: uberon
has_related_synonym: lobus parietalis
id: UBERON:0001872
in subset: efo slim
in subset: pheno slim
in subset: uberon slim

amygdala
type: Class
subclass of: basal ganglion
subclass of: cerebral hemisphere gray matter
definition: Subcortical brain region lying anterior to the hippocampal formation in the temporal lobe and anterior to the temporal horn of the lateral ventricle in some species. It is usually subdivided into several groups. Functionally, it is not considered a unitary structure (MM).
imported from: uberon.owl
external_definition: Subdivision of basal ganglion of telencephalon which is an almond-shaped gray mass in the dorsomedial part of the temporal lobe[FMA:61841]
homology_notes: One part of the striatum is called the archistriatum. (...) The archistriatum of fishes consists of several indistinctly segregated nuclei called the amygdaloid (...) complex. Tetrapods retain the structure, and in mammals the corresponding amygdala is a globular mass that tends to be ventral to the other basal nuclei.[well established][VHOG]
has_relational_adjective: amygdalar
external_ontology_notes: MA and FMA differ on relationship to basal ganglion. The FMA text def suggests a subdivision, but it is classified as a subtype
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Amygdala
database cross reference: http://linkedlifedata.com/resource/umls/id/C0002708
database cross reference: http://www.snomedbrowser.com/Codes/Details/279404004
database cross reference: BAMS:AMY
database cross reference: BAMS:Amg
database cross reference: BAMS:Amy
database cross reference: BAMS:Amygdala
database cross reference: BAMS:Amygdaloid_complex
database cross reference: BIRNLEX:1241
database cross reference: BM:Tel-Am
database cross reference: BTO:0001042
database cross reference: CALOHA:TS-0037
database cross reference: DHBA:10361
database cross reference: EFO:0000252
database cross reference: EMAPA:32672
database cross reference: EMAPA:36051
database cross reference: EV:0100189
database cross reference: EV:0100190
database cross reference: FMA:61841
database cross reference: GAID:616
database cross reference: HBA:4327
database cross reference: MA:0000887
database cross reference: MAT:0000289
database cross reference: MESH:A08.186.211.577.090
database cross reference: MIAA:0000289
database cross reference: NCIT:C12440
database cross reference: OpenCyc:Mx4rwJC_2ZwpEbGdrcN5Y29ycA
database cross reference: PBA:4002
database cross reference: UMLS:C0002708
database cross reference: VHOG:0001277
has exact synonym: amygdaloid body
has exact synonym: amygdaloid complex
has exact synonym: amygdaloid nuclear complex
has exact synonym: amygdaloid nuclear groups
has exact synonym: archistriatum
has_obo_namespace: uberon
has_related_synonym: amygdaloid area
has_related_synonym: amygdaloid nuclear group
has_related_synonym: amygdaloid nucleus
has_related_synonym: corpus amygdalae
has_related_synonym: corpus amygdaloideum
has_related_synonym: nucleus amygdalae
id: UBERON:0001876
in subset: efo slim
in subset: pheno slim
in subset: uberon slim

diencephalon
type: Class
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: The division of the forebrain that develops from the foremost primary cerebral vesicle.
imported from: uberon.owl
present in taxon: NCBITaxon 7762
external_definition: The more posterior and ventral of two forebrain neuromeres, the other being the telencephalon; major derivatives are the eye cups, the brain pretectal region, the thalamus, hypothalamus, and epithalamus (including the habenula and epiphysis). Kimmel et al, 1995.[TAO]
external_definition: Unpaired part of the forebrain comprised of three major parts; the epithalamus, thalamus, and hypothalamus.[AAO]
homology_notes: Fine structural, computerized three-dimensional (3D) mapping of cell connectivity in the amphioxus nervous system and comparative molecular genetic studies of amphioxus and tunicates have provided recent insights into the phylogenetic origin of the vertebrate nervous system. The results suggest that several of the genetic mechanisms for establishing and patterning the vertebrate nervous system already operated in the ancestral chordate and that the nerve cord of the proximate invertebrate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.[well established][VHOG]
has_relational_adjective: diencephalic
external_ontology_notes: in ABA, this is part of the brain stem
has_broad_synonym: DiE
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Diencephalon
database cross reference: http://linkedlifedata.com/resource/umls/id/C0012144
database cross reference: http://www.snomedbrowser.com/Codes/Details/279328001
database cross reference: AAO:0010481
database cross reference: BAMS:DI
database cross reference: BAMS:Di
database cross reference: BAMS:DiE
database cross reference: BAMS:IB
database cross reference: BAMS:Zh.
database cross reference: BIRNLEX:1503
database cross reference: BM:Die
database cross reference: BTO:0000342
database cross reference: CALOHA:TS-0199
database cross reference: DHBA:10389
database cross reference: DMBA:16308
database cross reference: EFO:0000911
database cross reference: EHDAA2:0000385
database cross reference: EHDAA:1969
database cross reference: EHDAA:2645
database cross reference: EHDAA:3472
database cross reference: EMAPA:16896
database cross reference: EV:0100194
database cross reference: FMA:62001
database cross reference: GAID:618
database cross reference: HBA:4391
database cross reference: MA:0000171
database cross reference: MAT:0000420
database cross reference: MBA:1129
database cross reference: MESH:A08.186.211.730.385
database cross reference: MIAA:0000420
database cross reference: NCIT:C12456
database cross reference: OpenCyc:Mx4rwC-V0JwpEbGdrcN5Y29ycA
database cross reference: PBA:128013010
database cross reference: TAO:0000101
database cross reference: UMLS:C0012144
database cross reference: VHOG:0000318
database cross reference: XAO:0000013
database cross reference: ZFA:0000101
has exact synonym: between brain
has exact synonym: interbrain
has exact synonym: mature diencephalon
has exact synonym: thalamencephalon
has_obo_namespace: uberon
has_related_synonym: betweenbrain
has_related_synonym: diencephalon
id: UBERON:0001894
in subset: efo slim
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

lateral geniculate body
type: Class
subclass of: Thalamus
subclass of: gray matter
definition: the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe
imported from: uberon.owl
present in taxon: NCBITaxon_117569
external_ontology_notes: BTO has distinct classes for body and nucleus, but other sources treat as identical
has_broad_synonym: LGN
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Lateral geniculate body
database cross reference: http://linkedlifedata.com/resource/umls/id/C0086526
database cross reference: http://www.snomedbrowser.com/Codes/Details/362377006
database cross reference: BAMS:C.gl.
database cross reference: BAMS:LG
database cross reference: BIRNLEX:1662
database cross reference: BTO:0004366
database cross reference: BTO:0004367
database cross reference: DHBA:10429
database cross reference: EFO:0001988
database cross reference: EMAPA:35478
database cross reference: EV:0100219
database cross reference: FMA:62209
database cross reference: MA:0000869
database cross reference: NCIT:C32556
database cross reference: PBA:128013070
database cross reference: UMLS:C0086526
has exact synonym: corpus geniculatum laterales
has exact synonym: lateral geniculate complex
has exact synonym: lateral geniculate nucleus
has exact synonym: nucleus geniculatus lateralis
has_obo_namespace: uberon
has_related_synonym: LGB
has_related_synonym: corpus geniculatum externum
has_related_synonym: corpus geniculatum laterale
has_related_synonym: corpus geniculatus lateralis
has_related_synonym: external geniculate body
has_related_synonym: nucleus corporis geniculati lateralis
id: UBERON:0001926
in subset: efo slim
in subset: pheno slim
in subset: uberon slim

neocortex
type: Class
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: An area of cerebral cortex defined on the basis of cytoarchitecture that have six layers. Starting from the cortical surface the layers are: molecular layer (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. It is composed of two subdivisions: true isocortex and proisocortex (Carpenter-83)(NN).
imported from: uberon.owl
homology_notes: The 6-layer neocortex is well conserved in all extant mammals, but not present in birds or reptils
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Neocortex
database cross reference: http://linkedlifedata.com/resource/umls/id/C0175173
database cross reference: BAMS:ISO
database cross reference: BAMS:Iso-cortex
database cross reference: BAMS:NCX
database cross reference: BIRNLEX:2547
database cross reference: BTO:0000920
database cross reference: DHBA:10160
database cross reference: EHDAA2:0004662
database cross reference: EMAPA:32842
database cross reference: EMAPA:35589
database cross reference: FMA:62429
database cross reference: GAID:677
database cross reference: MA:0002754
database cross reference: MBA:315
database cross reference: MESH:A08.186.211.730.885.213.420
database cross reference: PBA:294021746
database cross reference: UMLS:C0175173
has exact synonym: cerebral neocortex
has exact synonym: homogenetic cortex
has exact synonym: homotypical cortex
has exact synonym: isocortex (sensu lato)
has exact synonym: neocortex (isocortex)
has exact synonym: neopallial cortex
has exact synonym: neopallium
has_narrow_synonym: isocortex
has_obo_namespace: uberon
has_related_synonym: iso-cortex
has_related_synonym: nonolfactory cortex
has_related_synonym: nucleus hypoglossalis
id: UBERON:0001950
in subset: pheno slim
in subset: uberon slim

endothelium
type: Class
subclass of: simple squamous epithelium
subclass of: meso-epithelium
definition: A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA].
imported from: uberon.owl
has_relational_adjective: endothelial
database cross reference: http://linkedlifedata.com/resource/umls/id/C0014257
database cross reference: http://www.snomedbrowser.com/Codes/Details/27168002
database cross reference: BTO:0000393
database cross reference: CALOHA:TS-0278
database cross reference: EFO:0002548
database cross reference: FMA:63916
database cross reference: GAID:520
database cross reference: MESH:D004727
database cross reference: NCIT:C12481
database cross reference: UMLS:C0014257
database cross reference: galen:Endothelium
has_obo_namespace: uberon
id: UBERON:0001986
in subset: efo slim
in subset: uberon slim
comment: The term 'endothelium' has been either restricted to the continuous cell layer of the vertebrates, as we are assuming here, or applied to all the cells able to adhere to the luminal surface of the vascular basement membrane (Casley-Smith 1980)

gray matter
type: Class
subclass of: central nervous system cell part cluster
definition: A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons.
imported from: uberon.owl
external_definition: Multi-tissue comprised of neurons, dendrites, axon terminals, glial cells, and capillaries.[TAO]
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Gray matter
database cross reference: http://linkedlifedata.com/resource/umls/id/C0018220
database cross reference: AEO:0001012
database cross reference: EHDAA2:0003136
database cross reference: EHDAA2_RETIRED:0004658
database cross reference: EMAPA:37596
database cross reference: FMA:67242
database cross reference: HBA:4006
database cross reference: MA:0001112
database cross reference: NCIT:C32695
database cross reference: OpenCyc:Mx4rwDdKMpwpEbGdrcN5Y29ycA
database cross reference: TAO:0002197
database cross reference: UMLS:C0018220
database cross reference: VHOG:0001768
database cross reference: ZFA:0001681
has exact synonym: gray matter
has exact synonym: gray matter of neuraxis
has exact synonym: grey matter
has exact synonym: grey matter of neuraxis
has exact synonym: grey substance
has exact synonym: neuronal grey matter
has exact synonym: substantia grisea
has_obo_namespace: uberon
has_related_synonym: gray mater
has_related_synonym: grisea
id: UBERON:0002020
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

cerebellum
type: Class
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA].
imported from: uberon.owl
never in taxon: NCBITaxon_117565
dubious_for_taxon: NCBITaxon_117569
present in taxon: NCBITaxon_117569
external_definition: Dorsal part of the hindbrain that coordinates muscle movement, posture, and balance.[AAO]
external_definition: Specialized brain region derived from the dorsal metencephalon (anterior hindbrain, and perhaps including posterior midbrain) and becoming distinctive late in the segmentation period. Kimmel et al, 1995.[TAO]
homology_notes: However, although the lamprey possesses a region comparable to the cerebellum and display expression of LjFgf8/17 at the MHB (midbrain hindbrain boundary), it does not have Purkinje cells and cerebellar nuclei, as well as components of the rhombic lip-derived cerebellar and pre-cerebellar systems. It is noteworthy that the latter structures require specific expression of Pax6 in the rhombic lip of the gnathostome hindbrain. Interestingly, the lamprey rhombic lip does not express Pax6. Thus, it is tempting to speculate that in vertebrate evolution the rostral hindbrain is incapable of differentiating into the cerebellum before the co-option of Pax6 in that region. In other words, cerebellum has been brought about as an evolutionary innovation in gnathostomes, based on exaptation of MHB, rhombic lip, and some regulatory gene expression already present in the vertebrate common ancestor.[well established][VHOG]
has_relational_adjective: cerebellar
taxon_notes: The absence of a cerebellum in hagfishes and lampreys appears to be the only exception [to the rule that vertebrates possess the same number of brain divisions]. Both hagfishes and lampreys do possess a thin band of cells located medial to the lateral line centers of the medulla (Ronan and Northcutt, 1998), which has been interpreted as a primitive cerebellum (Larsell, 1967), but more recent experimental studies (Kishida et al., 1987; Weigle and Northcutt, 1998) fail to support Larsell's claim[http://icb.oxfordjournals.org/content/42/4/743.full]
external_ontology_notes: almost all AOs agree that the cerebellum is part of the hindbrain (sometimes specifically part of the metencephalon, which, when present, is part of the hindbrain). However, ABA has cerebellum and brain stem as partof siblings, with the hindbrain part of the brainstem
has_broad_synonym: infratentorial region
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Cerebellum
database cross reference: http://linkedlifedata.com/resource/umls/id/C0007765
database cross reference: http://linkedlifedata.com/resource/umls/id/C1268981
database cross reference: http://www.snomedbrowser.com/Codes/Details/180924008
database cross reference: AAO:0010485
database cross reference: BAMS:CB
database cross reference: BAMS:Cb
database cross reference: BIRNLEX:1489
database cross reference: BM:CB
database cross reference: BTO:0000232
database cross reference: CALOHA:TS-0125
database cross reference: DHBA:10656
database cross reference: EFO:0000327
database cross reference: EHDAA2:0000232
database cross reference: EMAPA:17787
database cross reference: EV:0100293
database cross reference: FMA:67944
database cross reference: GAID:595
database cross reference: HBA:4696
database cross reference: MA:0000198
database cross reference: MAT:0000110
database cross reference: MBA:512
database cross reference: MESH:D002531
database cross reference: MIAA:0000110
database cross reference: NCIT:C12445
database cross reference: OpenCyc:Mx4rvl1eipwpEbGdrcN5Y29ycA
database cross reference: TAO:0000100
database cross reference: UMLS:C0007765
database cross reference: UMLS:C1268981
database cross reference: VHOG:0000024
database cross reference: XAO:0003098
database cross reference: ZFA:0000100
has exact synonym: epencephalon-1
has_obo_namespace: uberon
has_related_synonym: corpus cerebelli
has_related_synonym: parencephalon
id: UBERON:0002037
in subset: efo slim
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

substantia nigra
type: Class
subclass of: midbrain nucleus
definition: Predominantly gray matter midbrain structure lying dorsal to the crus cerebri and ventral to the midbrain tegmentum. It is divided into a dorsal, cellularly compact region known as the pars compacta and a more ventrally located, containing more loosely packed cells, the pars reticulata. The most lateral region of the reticulata is identified as the pars lateralis (MM).
editor note: TODO - In BTO and NIF, part of basal ganglion which is part of telencephalon - but this is inconsistent with being part of midbrain, if these are spatially disjoint, as in ABA
imported from: uberon.owl
external_definition: Subdivision of the midbrain anterior to the midbrain tegmentum which contains darkly pigmented neurons[FMA][FMA:67947].
homology_notes: (...) the substantia nigra first appears in reptiles and is best developed in primates.[well established][VHOG]
has_broad_synonym: SN
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Substantia nigra
database cross reference: http://linkedlifedata.com/resource/umls/id/C0038590
database cross reference: http://linkedlifedata.com/resource/umls/id/C1269578
database cross reference: http://www.snomedbrowser.com/Codes/Details/279286002
database cross reference: BAMS:SN
database cross reference: BIRNLEX:789
database cross reference: BTO:0000143
database cross reference: CALOHA:TS-0990
database cross reference: DHBA:12251
database cross reference: EFO:0000922
database cross reference: EHDAA2:0004711
database cross reference: EMAPA:35835
database cross reference: EV:0100247
database cross reference: FMA:67947
database cross reference: GAID:581
database cross reference: HBA:9072
database cross reference: MA:0000210
database cross reference: MAT:0000504
database cross reference: MESH:A08.186.211.132.659.687
database cross reference: NCIT:C12453
database cross reference: UMLS:C0038590
database cross reference: UMLS:C1269578
database cross reference: VHOG:0001573
has exact synonym: Soemmering's substance
has exact synonym: nucleus of basis pedunculi
has_obo_namespace: uberon
has_related_synonym: nucleus pigmentosus subthalamo-peduncularis
has_related_synonym: substancia nigra
has_related_synonym: substantia nigra (Soemmerringi)
id: UBERON:0002038
in subset: efo slim
in subset: pheno slim
in subset: uberon slim

locus ceruleus
type: Class
subclass of: brainstem nucleus
subclass of: hindbrain nucleus
definition: The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID].
editor note: TODO - check ZFA/pons. also GO says part of dorsorostral pons
imported from: uberon.owl
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Locus ceruleus
database cross reference: http://linkedlifedata.com/resource/umls/id/C0023951
database cross reference: http://www.snomedbrowser.com/Codes/Details/369016004
database cross reference: BAMS:CAE
database cross reference: BAMS:LC
database cross reference: BIRNLEX:905
database cross reference: BM:Pons-LC
database cross reference: BTO:0001408
database cross reference: DHBA:12819
database cross reference: DMBA:16972
database cross reference: EFO:0001963
database cross reference: EMAPA:35502
database cross reference: FMA:72478
database cross reference: GAID:577
database cross reference: HBA:9148
database cross reference: MA:0001017
database cross reference: MBA:147
database cross reference: MESH:D008125
database cross reference: NCIT:C97333
database cross reference: TAO:0000539
database cross reference: UMLS:C0023951
database cross reference: ZFA:0000539
has exact synonym: blue nucleus
has exact synonym: caerulean nucleus
has exact synonym: locus caeruleus
has exact synonym: locus coeruleu
has exact synonym: locus coeruleus
has exact synonym: nucleus caeruleus
has exact synonym: nucleus of locus caeruleus
has exact synonym: nucleus pigmentosus pontis
has exact synonym: substantia ferruginea
has_obo_namespace: uberon
has_related_synonym: loci coeruleus
has_related_synonym: locus cinereus
has_related_synonym: locus coeruleus (Vicq d'Azyr)
has_related_synonym: nucleus loci caerulei
id: UBERON:0002148
in subset: efo slim
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

spinal cord
type: Class
subclass of: cavitated compound organ
subclass of: ectoderm-derived structure
subclass of: dorsal region element
subclass of: structure with developmental contribution from neural crest
definition: Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).
editor note: TODO - add superclass to unify with VNC?
imported from: uberon.owl
external_definition: Part of the central nervous system which descends from the hindbrain within the vertebral column.[AAO]
homology_notes: (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...) (reference 1); The neural tube is destined to differentiate into the brain and spinal cord (the central nervous system) (reference 2).[well established][VHOG]
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Spinal cord
database cross reference: http://linkedlifedata.com/resource/umls/id/C0037925
database cross reference: http://www.snomedbrowser.com/Codes/Details/180959008
database cross reference: AAO:0010151
database cross reference: BAMS:SP
database cross reference: BAMS:Spinal
database cross reference: BIRNLEX:1709
database cross reference: BM:SpC
database cross reference: BTO:0001279
database cross reference: CALOHA:TS-0953
database cross reference: DHBA:12890
database cross reference: DMBA:17651
database cross reference: EFO:0000110
database cross reference: EHDAA2:0001255
database cross reference: EHDAA:2863
database cross reference: EMAPA:17577
database cross reference: EV:0100316
database cross reference: FMA:7647
database cross reference: GAID:695
database cross reference: MA:0000216
database cross reference: MAT:0000183
database cross reference: MESH:D013116
database cross reference: MIAA:0000183
database cross reference: NCIT:C12464
database cross reference: OpenCyc:Mx4rvVjjk5wpEbGdrcN5Y29ycA
database cross reference: TAO:0000075
database cross reference: UMLS:C0037925
database cross reference: VHOG:0000601
database cross reference: XAO:0000020
database cross reference: ZFA:0000075
has_obo_namespace: uberon
has_related_synonym: SpC
has_related_synonym: cerebro-cerebellar fissure
has_related_synonym: cerebrocerebellar fissure
has_related_synonym: fissura cerebro-cerebellaris
has_related_synonym: fissura cerebrocerebellaris
has_related_synonym: medulla spinalis
has_related_synonym: spinal cord structure
has_related_synonym: spinal medulla
id: UBERON:0002240
in subset: cumbo
in subset: efo slim
in subset: major organ
in subset: organ slim
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core

brainstem
type: Class
subclass of: multi-tissue structure
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized].
imported from: uberon.owl
external_definition: Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain.[TAO]
external_definition: Multi-tissue structure that has as its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,adopted][ZFA:0001707].
external_definition: the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord[MP]
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Brainstem
database cross reference: http://linkedlifedata.com/resource/umls/id/C0006121
database cross reference: http://www.snomedbrowser.com/Codes/Details/180925009
database cross reference: BAMS:BS
database cross reference: BIRNLEX:1565
database cross reference: BTO:0000146
database cross reference: CALOHA:TS-0093
database cross reference: EFO:0001962
database cross reference: EMAPA:32678
database cross reference: EV:0100241
database cross reference: FMA:79876
database cross reference: MA:0000169
database cross reference: MBA:343
database cross reference: MESH:D001933
database cross reference: NCIT:C12441
database cross reference: TAO:0002156
database cross reference: UMLS:C0006121
database cross reference: VHOG:0001457
database cross reference: ZFA:0001707
has exact synonym: brain stem
has exact synonym: truncus encephali
has_obo_namespace: uberon
has_related_synonym: accessory medullary lamina of pallidum
has_related_synonym: lamella pallidi incompleta
has_related_synonym: lamina medullaris accessoria
has_related_synonym: lamina medullaris incompleta pallidi
has_related_synonym: lamina pallidi incompleta
has_related_synonym: truncus encephalicus
id: UBERON:0002298
in subset: efo slim
in subset: pheno slim
in subset: uberon slim
in subset: vertebrate core
comment: 'brainstem' is a loose term that sometimes refers to the ventral parts o the brain except for any part of the telencephalon - sometimes it includes the diencephalon or subpallial telencephalon structures (ISBN:0471888893). Here we use it in a more restriced sense, to include only the medulla oblongata, pons (when present) and the midbrain tegmentum (following the ZFA definitions).

layer of dentate gyrus
type: Class
subclass of: central nervous system cell part cluster
subclass of: nervous system cell part layer
definition: One of the three layers of the dentate gyrus of the hippocampal formation.
imported from: uberon.owl
taxon_notes: the basic trilaminar structure of the dentate gyrus is common across all species studied, with relatively minimal phylogenetic variation[PMC2492885]
database cross reference: EMAPA:35278
database cross reference: FMA:83678
database cross reference: MA:0002429
has exact synonym: dentate gyrus cell layer
has exact synonym: dentate gyrus layer
has_obo_namespace: uberon
id: UBERON:0002304

nucleus of brain
type: Class
subclass of: neural nucleus
definition: A neural nucleus that is part of the brain.
imported from: uberon.owl
database cross reference: http://linkedlifedata.com/resource/umls/id/C1706993
database cross reference: http://www.snomedbrowser.com/Codes/Details/426465002
database cross reference: EMAPA:35185
database cross reference: FMA:83840
database cross reference: MA:0000811
database cross reference: NCIT:C49346
database cross reference: UMLS:C1706993
database cross reference: ZFA:0005575
has exact synonym: brain nucleus
has_obo_namespace: uberon
has_related_synonym: brain nuclei
id: UBERON:0002308

white matter
type: Class
subclass of: central nervous system cell part cluster
definition: Neural tissue consisting of myelinated axons connecting grey matter areas of the central nervous system.
imported from: uberon.owl
external_definition: Cell part cluster consisting predominantly of neurites in the brain and the spinal cord[FMA:83929].
external_definition: Multi-tissue structure comprised largely of myelinated axons.[TAO]
homology_notes: The myelination of axons by glial cells was the last major step in the evolution of cells in the vertebrate nervous system, and white-matter tracts are key to the architecture of the mammalian brain.[well established][VHOG]
external_ontology_notes: nlx_anat_101177 seems to have been lost in the transition from NIFGA to Neurolex
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: White matter
database cross reference: http://linkedlifedata.com/resource/umls/id/C0682708
database cross reference: AEO:0000139
database cross reference: AEO:0001011
database cross reference: EMAPA:35927
database cross reference: FMA:83929
database cross reference: HBA:9218
database cross reference: MA:0001135
database cross reference: NCIT:C33892
database cross reference: NLX:412
database cross reference: NLXANAT:101177
database cross reference: OpenCyc:Mx4rwOAsDZwpEbGdrcN5Y29ycA
database cross reference: PBA:294022044
database cross reference: TAO:0000145
database cross reference: TAO:0002142
database cross reference: TAO:0002143
database cross reference: UMLS:C0682708
database cross reference: VHOG:0001764
database cross reference: ZFA:0001682
has exact synonym: CNS tract/commissure
has exact synonym: neuronal white matter
has exact synonym: white matter of neuraxis
has exact synonym: white substance
has_obo_namespace: uberon
has_related_synonym: CNS tracts and commissures
has_related_synonym: CNS white matter
has_related_synonym: substantia alba
has_related_synonym: white mater
id: UBERON:0002316
in subset: uberon slim
in subset: vertebrate core

basal ganglion
type: Class
subclass of: brain gray matter
subclass of: nuclear complex of neuraxis
definition: An individual member of a collection of basal ganglia. Basal ganglia are subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum[NIF,modified].
editor note: it is necessary to introduce two classes, one representing an individual basal ganglion, another representing the aggregate structure, in order to have consistent classification amongst AOs (e.g. in MA the aygdala is part of the BG, in FMA and BTO it is a subclass). Apart from achieving this consistency, the value of having two distinct classes is questionable, since the BG-plural is trivially the set of all BGs-singular. it would be better for all AOs to decide on one single way of doing this. Do not merge until this is done.
imported from: uberon.owl
database cross reference: http://www.snomedbrowser.com/Codes/Details/244434001
database cross reference: BTO:0000235
database cross reference: CALOHA:TS-1149
database cross reference: DHBA:10332
database cross reference: EFO:0000904
database cross reference: FMA:62514
has exact synonym: basal ganglion of telencephalon
has_obo_namespace: uberon
has_related_synonym: basal ganglia
has_related_synonym: basal nucleus
has_related_synonym: nuclei basales
id: UBERON:0002420
in subset: efo slim
in subset: pheno slim
in subset: uberon slim

hippocampal formation
type: Class
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: Hippocampus (proper) plus dentate gyrus and subiculum[definition derived from NIF comments and ontology alignment].
curator note: The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum
imported from: uberon.owl
external_ontology_notes: BTO:0000601 is placed here since it includes the DG. GO also includes dentate gyrus development as part of hippocampus development, so we assume when GO says 'hippocampus' it means 'hippocampal formation'. In ABA HPF = (.. subiculum) + HIP, HIP = DG + AH.
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Hippocampal formation
database cross reference: http://linkedlifedata.com/resource/umls/id/C0175202
database cross reference: http://www.snomedbrowser.com/Codes/Details/422867004
database cross reference: BAMS:HPF
database cross reference: BAMS:Hi
database cross reference: BAMS:HiF
database cross reference: BIRNLEX:715
database cross reference: BM:Tel-HF
database cross reference: BTO:0000601
database cross reference: DHBA:10294
database cross reference: EMAPA:35405
database cross reference: FMA:74038
database cross reference: HBA:4249
database cross reference: MA:0000189
database cross reference: MBA:1089
database cross reference: PBA:4003
database cross reference: UMLS:C0175202
has exact synonym: hippocampus (Crosby)
has_narrow_synonym: hippocampus
has_obo_namespace: uberon
has_related_synonym: archipallium
has_related_synonym: formatio hippocampi
has_related_synonym: major hippocampus
has_related_synonym: primal cortex
has_related_synonym: seahorse
id: UBERON:0002421
in subset: pheno slim
in subset: uberon slim

striatum
type: Class
subclass of: gray matter of telencephalon
definition: A region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.[GO].
imported from: uberon.owl
has_relational_adjective: striatal
external_ontology_notes: FMA divides 'striatum of neuraxis' into 4, neostriatum is seperate class. In NIF these are synonyms. TODO - check striatum vs corpus striatum see Wikipedia:Striatum#History. Check caudoputamen
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Striatum
database cross reference: http://linkedlifedata.com/resource/umls/id/C0162512
database cross reference: BAMS:STR
database cross reference: BAMS:Str
database cross reference: BAMS:Striatum
database cross reference: BIRNLEX:1672
database cross reference: BM:N
database cross reference: BTO:0000418
database cross reference: DHBA:10333
database cross reference: DMBA:15851
database cross reference: EFO:0000109
database cross reference: EMAPA:17549
database cross reference: FMA:77618
database cross reference: FMA:83683
database cross reference: HBA:4277
database cross reference: MA:0000891
database cross reference: MBA:477
database cross reference: MESH:A08.186.211.730.885.105.487.550
database cross reference: NCIT:C111122
database cross reference: PBA:10080
database cross reference: UMLS:C0162512
database cross reference: ncithesaurus:Striatum
has exact synonym: neostriatum
has exact synonym: neuraxis striatum
has exact synonym: striate nucleus
has exact synonym: striatum
has exact synonym: striatum of neuraxis
has_obo_namespace: uberon
has_related_synonym: caudate putamen
has_related_synonym: corpus striatum
has_related_synonym: corpus striatum (Zilles)
has_related_synonym: dorsal striatum
has_related_synonym: striated nucleus
id: UBERON:0002435
in subset: pheno slim
in subset: uberon slim

limbic lobe
type: Class
subclass of: lobe of cerebral hemisphere
definition: Part of cerebral hemisphere located on the medial surface, forming a ring around the brain stem.
imported from: uberon.owl
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Limbic lobe
database cross reference: http://linkedlifedata.com/resource/umls/id/C0458337
database cross reference: http://www.snomedbrowser.com/Codes/Details/279215006
database cross reference: BAMS:LL
database cross reference: BAMS:Limbic_lobe
database cross reference: BIRNLEX:1128
database cross reference: CALOHA:TS-2061
database cross reference: DHBA:12155
database cross reference: FMA:72719
database cross reference: HBA:4219
database cross reference: UMLS:C0458337
has exact synonym: fornicate gyrus
has exact synonym: grande lobe limbique of Broca
has exact synonym: limbic lobe (carpenter)
has_obo_namespace: uberon
has_related_synonym: fornicate convolution
has_related_synonym: fornicate lobe
has_related_synonym: gyrus fornicatus
has_related_synonym: lobus limbicus
id: UBERON:0002600
in subset: pheno slim
in subset: uberon slim

regional part of brain
type: Class
subclass of: regional part of nervous system
subclass of: ectoderm-derived structure
definition: Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia.
imported from: uberon.owl
database cross reference: http://linkedlifedata.com/resource/umls/id/C0445620
database cross reference: http://www.snomedbrowser.com/Codes/Details/384763002
database cross reference: BIRNLEX:1167
database cross reference: FMA:55676
database cross reference: NCIT:C13031
database cross reference: UMLS:C0445620
has exact synonym: anatomical structure of brain
has exact synonym: biological structure of brain
has exact synonym: brain anatomical structure
has exact synonym: brain biological structure
has exact synonym: brain part
has exact synonym: neuraxis segment
has exact synonym: neuroanatomical region
has exact synonym: segment of brain
has_obo_namespace: uberon
id: UBERON:0002616
in subset: non informative

entorhinal cortex
type: Class
subclass of: organ part
subclass of: ectoderm-derived structure
subclass of: structure with developmental contribution from neural crest
definition: Component of the temporal lobe on the mesial surface. The rostral and caudal boundaries of the entorhinal cortex are the rostral end of the collateral sulcus and the caudal end of the amygdala respectively. The medial boundary is the medial aspect of the temporal lobe and the lateral boundary is the collateral sulcus. (DK).
editor note: TODO - check area vs complex. MBA:909 this is part of the hippocampal formation via retrohippocampal region
imported from: uberon.owl
taxon_notes: In primates it is found on the medial surface of the temporal lobe, partially bounded ventrolaterally by the collateral sulcus in the human and by the rhinal sulcus in the macaque. It is subdivided on the basis of internal structure into eight parts in the human ( Insausti-2004 ),and seven parts in the macaque ( Paxinos-2009a ). In the rat and mouse it is divided into a lateral part of the entorhinal area and a medial part of the entorhinal area; the latter is further divided into dorsal and ventral zones to produce three subdivisions in the rodent ( Swanson-2004 )
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Entorhinal cortex
database cross reference: http://linkedlifedata.com/resource/umls/id/C0175196
database cross reference: http://www.snomedbrowser.com/Codes/Details/369099007
database cross reference: BAMS:ENT
database cross reference: BAMS:Ent
database cross reference: BIRNLEX:1508
database cross reference: BM:Tel-Cx-ENT
database cross reference: BTO:0002650
database cross reference: DHBA:10317
database cross reference: DMBA:16102
database cross reference: EFO:0001920
database cross reference: EMAPA:35313
database cross reference: FMA:72356
database cross reference: GAID:636
database cross reference: MA:0003117
database cross reference: MBA:909
database cross reference: MESH:A08.186.211.577.710.225
database cross reference: NCIT:C97338
database cross reference: PBA:294022158
database cross reference: UMLS:C0175196
has exact synonym: entorhinal area
has_obo_namespace: uberon
has_related_synonym: Brodmann's area 28
has_related_synonym: area entorhinalis (28,34)
has_related_synonym: area entorhinalis ventralis et dorsalis
has_related_synonym: cortex entorhinalis
has_related_synonym: entorhinal cortex
id: UBERON:0002728
in subset: efo slim
in subset: pheno slim
in subset: uberon slim

inferior temporal gyrus
type: Class
subclass of: gyrus
definition: Component of the temporal lobe, lateral aspect. The rostral boundary is the rostral extent of the inferior temporal sulcus whereas the caudal boundary is designated as the temporo-occipital incisure on the cortical surface. The occipitotemporal sulcus is the medial boundary and the inferior temporal sulcus is the lateral boundary (Christine Fennema-Notestine).
imported from: uberon.owl
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Inferior temporal gyrus
database cross reference: http://www.snomedbrowser.com/Codes/Details/279191005
database cross reference: BAMS:ITG
database cross reference: BIRNLEX:1577
database cross reference: BM:Tel-ITG
database cross reference: DHBA:12142
database cross reference: FMA:61907
database cross reference: HBA:4147
database cross reference: NCIT:C32791
database cross reference: ncithesaurus:Inferior_Temporal_Gyrus
has exact synonym: gyrus temporalis inferior
has exact synonym: lateral occipitotemporal gyrus (heimer-83)
has_obo_namespace: uberon
has_related_synonym: IT cortex
has_related_synonym: gyrus temporalis inferior
has_related_synonym: inferotemporal cortex
id: UBERON:0002751
in subset: uberon slim

cingulate cortex
type: Class
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: The cingulate cortex is a part of the brain situated in the medial aspect of the cortex. It is extended from the corpus callosum below to the cingulate sulcus above, at least anteriorly. [WP,unvetted].
imported from: uberon.owl
database cross reference: Cingulate cortex
database cross reference: http://linkedlifedata.com/resource/umls/id/C0598179
database cross reference: BIRNLEX:934
database cross reference: BM:Tel-Cx-Cg
database cross reference: BTO:0003975
database cross reference: DHBA:10277
database cross reference: DMBA:16072
database cross reference: EFO:0000343
database cross reference: EMAPA:35242
database cross reference: MA:0000904
database cross reference: NCIT:C52713
database cross reference: UMLS:C0598179
has exact synonym: cingulate neocortex
has_obo_namespace: uberon
has_related_synonym: gyrus cingulatus
has_related_synonym: gyrus cinguli
id: UBERON:0003027
in subset: efo slim
in subset: uberon slim

compound organ
type: Class
subclass of: organ
definition: Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types.
curator note: this class was introduced for consistency with CARO. However, in this ontology we typically classify organs directly under 'organ' rather than subdividing into compound and simple organs
imported from: uberon.owl
database cross reference: AAO:0010015
database cross reference: AEO:0000024
database cross reference: BILA:0000024
database cross reference: CARO:0000024
database cross reference: EHDAA2:0003024
database cross reference: HAO:0000024
database cross reference: TADS:0000598
database cross reference: TAO:0000496
database cross reference: TGMA:0001837
database cross reference: VHOG:0001723
database cross reference: XAO:0003041
database cross reference: ZFA:0000496
has_obo_namespace: uberon
has_related_synonym: organ
id: UBERON:0003103
in subset: organ slim
in subset: upper level

brain gray matter
type: Class
subclass of: gray matter
definition: A gray matter that is part of a brain [Automatically generated definition].
imported from: uberon.owl
database cross reference: http://linkedlifedata.com/resource/umls/id/C1707348
database cross reference: EMAPA:35184
database cross reference: MA:0000810
database cross reference: NCIT:C49333
database cross reference: UMLS:C1707348
has exact synonym: brain grey matter
has exact synonym: brain grey substance
has exact synonym: gray matter of brain
has exact synonym: grey matter of brain
has exact synonym: grey substance of brain
has_obo_namespace: uberon
id: UBERON:0003528

hippocampal field
type: Class
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: a part or parts of the hippocampus that have a particular function
imported from: uberon.owl
external_ontology_notes: do not include ABA:HIP
database cross reference: BAMS:HIP
database cross reference: BAMS:Hi/CA
database cross reference: EMAPA:32772
database cross reference: FMA:74041
database cross reference: MA:0002428
has exact synonym: hippocampus subdivision
has exact synonym: subdivision of hippocampus
has_obo_namespace: uberon
has_related_synonym: hippocampal region
has_related_synonym: hippocampus region
id: UBERON:0003876
in subset: non informative
in subset: pheno slim

sinusoid
type: Class
subclass of: anatomical entity
definition: small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP].
imported from: uberon.owl
external_definition: Fenestrated blood vessel endothelium with pores that are large enough for blood cells to pass. The basal lamina and gap junctions may be discontinuous.[TAO]
has_relational_adjective: sinusoidal
external_ontology_notes: some sources give discontinuous capillary as synonym but this may be a subtype - see FMA:63198 discontinuous sinusoid (undefined).
database cross reference: Sinusoid (blood vessel)
database cross reference: http://www.snomedbrowser.com/Codes/Details/340163004
database cross reference: FMA:63131
database cross reference: TAO:0005261
database cross reference: ZFA:0005261
has exact synonym: sinusoidal blood vessel
has exact synonym: sinusoidal blood vessel endothelium
has_obo_namespace: uberon
has_related_synonym: endothelium of irregular blood filled space
has_related_synonym: sinusoidal capillary
has_related_synonym: sinusoidal endothelium
id: UBERON:0003909
in subset: vertebrate core

brain ventricle/choroid plexus
type: Class
subclass of: ectoderm-derived structure
subclass of: multicellular anatomical structure
definition: The brain ventricles or their associated choroid plexuses
editor note: TODO - check relationship between CP and BV. If this is part of then this class should be obsoleted
editor note: TODO merge into BV
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0003947
in subset: pheno slim

brain ventricle
type: Class
subclass of: brain ventricle/choroid plexus
subclass of: ventricle of nervous system
definition: one of the system of communicating cavities in the brain that are continuous with the central canal of the spinal cord, that like it are derived from the medullary canal of the embryo, that are lined with an epithelial ependyma, and that contain a serous fluid
imported from: uberon.owl
external_definition: Organ cavity of the brain which consists of the lateral ventricles, the third and fourth ventricles and the cerebral aqueduct[BIRNLEX:1356].
external_ontology_notes: FMA draws the distinction between e.g. 'fourth ventricle' and 'cavity of fourth ventricle'. The latter is a cavity, and part of the former, which is a region. The superclass of 'fourth ventricle' is_a 'region of ventricular system of the brain'. We place this class here, although it is not equivalent to ventricles, as it includes ventricle bodies.
contributor: cmungall
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: http://linkedlifedata.com/resource/umls/id/C0007799
database cross reference: http://www.snomedbrowser.com/Codes/Details/180929003
database cross reference: BIRNLEX:1356
database cross reference: BTO:0001442
database cross reference: EFO:0001914
database cross reference: EMAPA:32674
database cross reference: FMA:78447
database cross reference: HBA:9418
database cross reference: MA:0000818
database cross reference: MESH:D002552
database cross reference: NCIT:C12356
database cross reference: OpenCyc:Mx4rvmTY65wpEbGdrcN5Y29ycA
database cross reference: UMLS:C0007799
has exact synonym: brain ventricles
has exact synonym: cerebral ventricle
has exact synonym: region of ventricular system of brain
has_obo_namespace: uberon
id: UBERON:0004086
in subset: efo slim
in subset: pheno slim

mesoderm-derived structure
type: Class
subclass of: anatomical structure
definition: An anatomical structure that develops (entirely or partially) from the mesoderm.
curator note: Grouping term for query purposes
imported from: uberon.owl
database cross reference: FBbt:00025998
has exact synonym: mesodermal derivative
has_obo_namespace: uberon
id: UBERON:0004120
in subset: grouping class

ectoderm-derived structure
type: Class
subclass of: anatomical structure
definition: An anatomical structure that develops (entirely or partially) from the ectoderm.
curator note: Grouping term for query purposes
imported from: uberon.owl
database cross reference: FBbt:00025990
has exact synonym: ectodermal deriviative
has_obo_namespace: uberon
id: UBERON:0004121
in subset: grouping class

organ component layer
type: Class
subclass of: organ part
definition: A part of a wall of an organ that forms a layer.
imported from: uberon.owl
database cross reference: FMA:82485
has_obo_namespace: uberon
id: UBERON:0004923
in subset: upper level

multi cell part structure
type: Class
subclass of: material entity
subclass of: anatomical cluster
subclass of: anatomical entity
definition: A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part.
imported from: uberon.owl
external_ontology_notes: we go with the FMA classification rather than the CARO one. FMA def: 'Anatomical cluster which has as direct parts cell parts from two or more cells.'
database cross reference: AAO:0011000
database cross reference: CARO:0001000
database cross reference: FBbt:00007060
database cross reference: FMA:83115
has exact synonym: multi-cell-component structure
has exact synonym: multi-cell-part structure
has_obo_namespace: uberon
has_related_synonym: cell part cluster
id: UBERON:0005162
in subset: upper level

dorsal region element
type: Class
subclass of: organ
definition: An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back.
imported from: uberon.owl
database cross reference: EMAPA:37274
database cross reference: MA:0001901
has exact synonym: back organ
has exact synonym: dorsal region organ
has_obo_namespace: uberon
id: UBERON:0005174
in subset: non informative

ventricle of nervous system
type: Class
subclass of: Ventricle
definition: A layer in the central nervous system that lines system of communicating cavities in the brain and spinal cord.
imported from: uberon.owl
contributor: cmungall
database cross reference: EMAPA:35209
database cross reference: FMA:242770
has exact synonym: ventricular layer
has_obo_namespace: uberon
has_related_synonym: region of wall of ventricular system of neuraxis
id: UBERON:0005358

cerebral hemisphere gray matter
type: Class
subclass of: gray matter of telencephalon
definition: A gray matter that is part of a cerebral hemisphere.
imported from: uberon.owl
external_ontology_notes: BTO may actually be a more generic structure; FMA may represent a more specific structure. Consider merging with gray matter of telencephalon
database cross reference: BTO:0000823
database cross reference: CALOHA:TS-2361
database cross reference: EMAPA:37477
database cross reference: FMA:61821
database cross reference: MA:0000944
has exact synonym: cerebral gray matter
has exact synonym: cerebral grey matter
has exact synonym: cerebral hemisphere grey matter
has_obo_namespace: uberon
id: UBERON:0005401

zone of bone organ
type: Class
subclass of: zone of organ
imported from: uberon.owl
database cross reference: FMA:10483
has exact synonym: bone organ zone
has_obo_namespace: uberon
id: UBERON:0005913

bodily fluid
type: Class
subclass of: organism substance
definition: Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.
imported from: uberon.owl
has_broad_synonym: fluid
database cross reference: Body fluid
database cross reference: BIRNLEX:20
database cross reference: EMAPA:37441
database cross reference: FMA:280556
database cross reference: GAID:266
database cross reference: MESH:D001826
database cross reference: galen:BodyFluid
has exact synonym: body fluid
has_obo_namespace: uberon
id: UBERON:0006314
in subset: pheno slim

brainstem nucleus
type: Class
subclass of: nucleus of brain
definition: A nucleus of brain that is part of a brainstem.
imported from: uberon.owl
database cross reference: EMAPA:32790
database cross reference: MA:0000821
has_obo_namespace: uberon
has_related_synonym: brain stem nucleus
id: UBERON:0006331

squamous epithelium
type: Class
subclass of: epithelium
definition: An epithelium characterised by its most superficial layer consisting of squamous epithelial cells.
imported from: uberon.owl
external_ontology_notes: FBbt:00007028 (squamous epithelium) A type of epithelium that is made up of flattened cells which are arranged with their long axes in the plane of the epithelium
database cross reference: Squamous epithelium
database cross reference: http://linkedlifedata.com/resource/umls/id/C0221909
database cross reference: http://www.snomedbrowser.com/Codes/Details/40118003
database cross reference: BTO:0002072
database cross reference: NCIT:C12848
database cross reference: UMLS:C0221909
has_obo_namespace: uberon
id: UBERON:0006914

nuclear complex of neuraxis
type: Class
subclass of: gray matter
definition: Gray matter of the central nervous system which is a collection of clustered nuclei.
imported from: uberon.owl
database cross reference: FMA:256381
database cross reference: FMA:84059
has_obo_namespace: uberon
has_related_synonym: cluster of neural nuclei
has_related_synonym: neural nuclei
has_related_synonym: nuclear complex
id: UBERON:0007245

transudate
type: Class
subclass of: bodily fluid
definition: Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces.
imported from: uberon.owl
has_relational_adjective: transudative
structure_notes: characteristically low in protein and cellular content (unless there has been secondary concentration)
database cross reference: FMA:12276
database cross reference: GAID:1195
database cross reference: MESH:D005122
database cross reference: ncithesaurus:Transudate
has_obo_namespace: uberon
has_related_synonym: plasma ultrafiltrate
id: UBERON:0007779

midbrain nucleus
type: Class
subclass of: nucleus of brain
definition: Nucleus located in the midbrain.
imported from: uberon.owl
database cross reference: http://www.snomedbrowser.com/Codes/Details/279285003
database cross reference: TAO:0002209
database cross reference: ZFA:0001665
has_obo_namespace: uberon
id: UBERON:0009661

hindbrain nucleus
type: Class
subclass of: nucleus of brain
definition: Nucleus located within the hindbrain.
imported from: uberon.owl
database cross reference: TAO:0002177
database cross reference: ZFA:0001658
has_obo_namespace: uberon
id: UBERON:0009662

dorsolateral prefrontal cortex
type: Class
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: The dorsolateral prefrontal cortex (DL-PFC or DLPFC), according to a more restricted definition, is roughly equivalent to Brodmann areas 9 and 46.[1] According to a broader definition DL-PFC consists of the lateral portions of Brodmann areas 9 - 12, of areas 45, 46, and the superior part of area 47.[2] These regions mainly receive their blood supply from the middle cerebral artery. With respect to neurotransmitter systems, there is evidence that dopamine plays a particularly important role in DL-PFC.[2]DL-PFC is connected to the orbitofrontal cortex, and to a variety of brain areas, which include the thalamus, parts of the basal ganglia (the dorsal caudate nucleus), the hippocampus, and primary and secondary association areas of neocortex, including posterior temporal, parietal, and occipital areas.
editor note: check dorsolateral prefrontal neocortex
imported from: uberon.owl
database cross reference: Dorsolateral prefrontal cortex
database cross reference: DHBA:10173
database cross reference: FMA:276189
has_obo_namespace: uberon
id: UBERON:0009834

anterior cingulate cortex
type: Class
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: The frontal part of the cingulate cortex that resembles a collar form around the corpus callosum. It includes both the ventral and dorsal areas of the cingulate cortex. Wikipedia:File:Gray727.svg.
imported from: uberon.owl
database cross reference: Anterior cingulate cortex
database cross reference: BIRNLEX:936
database cross reference: BTO:0004249
database cross reference: FMA:271599
has_obo_namespace: uberon
has_related_synonym: ACC
id: UBERON:0009835

multicellular anatomical structure
type: Class
subclass of: anatomical structure
definition: An anatomical structure that has more than one cell as a part.
imported from: uberon.owl
database cross reference: CARO:0010000
database cross reference: FBbt:00100313
has exact synonym: multicellular structure
has_obo_namespace: uberon
id: UBERON:0010000
in subset: upper level

cell cluster organ
type: Class
subclass of: organ
subclass of: cell cluster
definition: A small cluster of cells of various types which form a discrete structure, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function.
imported from: uberon.owl
database cross reference: CARO:0010001
database cross reference: FBbt:00007229
has_obo_namespace: uberon
id: UBERON:0010001
in subset: upper level
comment: Examples include arthropod sensilla.

structure with developmental contribution from neural crest
type: Class
subclass of: anatomical structure
definition: An anatomical structure that has some part that develops from the neural crest.
curator note: Grouping term for query purposes
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0010314
in subset: grouping class

central nervous system cell part cluster
type: Class
subclass of: multi cell part structure
definition: A multi cell part structure that is part of a central nervous system.
imported from: uberon.owl
database cross reference: FMA:83143
has exact synonym: cell part cluster of neuraxis
has exact synonym: neuraxis layer
has_obo_namespace: uberon
id: UBERON:0011215
in subset: upper level

organ system subdivision
type: Class
subclass of: multicellular anatomical structure
definition: A subdivision of an anatomical system.
imported from: uberon.owl
database cross reference: http://www.snomedbrowser.com/Codes/Details/91690000
database cross reference: FBbt:00007330
database cross reference: FMA:67509
has_obo_namespace: uberon
id: UBERON:0011216
in subset: upper level

gray matter of telencephalon
type: Class
subclass of: gray matter of forebrain
definition: A portion of gray matter that is part of a telencephalon.
imported from: uberon.owl
has_alternative_id: UBERON:0024186
database cross reference: BIRNLEX:1067
database cross reference: FMA:83911
has exact synonym: predominantly gray regional part of telencephalon
has_obo_namespace: uberon
id: UBERON:0011300

meso-epithelium
type: Class
subclass of: epithelium
subclass of: mesoderm-derived structure
definition: Epithelium that derives from the mesoderm. [Automatically generated definition].
imported from: uberon.owl
database cross reference: FMA:86452
has exact synonym: mesoderm-derived epithelium
has exact synonym: mesoepithelium
has_obo_namespace: uberon
id: UBERON:0012275

Brodmann area
type: Class
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: A segmentation of the cerebral cortex on the basis of cytoarchitecture as described in Brodmann-1905, Brodmann-1909 and Brodmann-10. Maps for several species were presented. NeuroNames includes only areas in the human and in Old World monkeys. Of the latter, Brodmann studied representatives of several species including guenons (one Cercopithecus mona, one Cercocebus torquatus, and one Cercopithecus otherwise unspecified), which are all closely related African species, and one macaque (Macaca mulatta) an Asian species (Brodmann-1905). The legend to the summary map in Brodmann-1909 ascribes the areas simply to Cercopithecus. Brodmann referenced the areas by name and number. The same area number in humans and monkeys did not necessarily refer to topologically or cytoarchitecturally homologous structures. In NeuroNames the standard term for human areas consists of the English translation of Brodmann's Latin name followed by the number he assigned, e.g., agranular frontal area 6; the standard terms for monkey areas are in the format: area 6 of Brodmann-1909. He mapped a portion of areas limited to the banks of sulci, e.g., area 3 of Brodmann-1909 (Brodmann-1909) onto the adjacent, visible surface. This accounts for the fact that some areas appear larger on his surface map than on maps of other authors, e.g., area 3 of Vogts-1919. (Adapted from NeuroNames)
imported from: uberon.owl
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: Brodmann area
database cross reference: http://www.snomedbrowser.com/Codes/Details/384717008
database cross reference: BAMS:VTM
database cross reference: BIRNLEX:1731
database cross reference: FMA:68596
database cross reference: NCIT:C94868
database cross reference: WikipediaCategory:Brodmann_areas
has_obo_namespace: uberon
has_related_synonym: Brodmann parcellation scheme region
has_related_synonym: Brodmann partition scheme region
has_related_synonym: Brodmann's areas
id: UBERON:0013529

periventricular gray matter
type: Class
subclass of: brain gray matter
imported from: uberon.owl
database cross reference: http://www.snomedbrowser.com/Codes/Details/89530008
has exact synonym: periventricular grey matter
has_obo_namespace: uberon
id: UBERON:0014933

lateral structure
type: Class
subclass of: anatomical structure
definition: Any structure that is placed on one side of the left-right axis of a bilaterian.
curator note: This class is primarily to implement taxon constraints. It may be removed in the future.
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0015212
in subset: grouping class
in subset: non informative

frontal lobe
type: Class
subclass of: lobe of cerebral hemisphere
definition: Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border.
editor note: Many species don't have lobes but they do have frontal cortex. Lobe isn't a really well defined term though
imported from: uberon.owl
has_broad_synonym: frontal region
has_broad_synonym: regio frontalis
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: http://linkedlifedata.com/resource/umls/id/C0016733
database cross reference: http://linkedlifedata.com/resource/umls/id/C1268977
database cross reference: http://www.snomedbrowser.com/Codes/Details/180920004
database cross reference: BAMS:Frontal_lobe
database cross reference: BIRNLEX:928
database cross reference: BM:Tel-Cx-FR
database cross reference: CALOHA:TS-0389
database cross reference: DHBA:12113
database cross reference: EFO:0000913
database cross reference: EV:0100167
database cross reference: FMA:61824
database cross reference: HBA:4009
database cross reference: MAT:0000505
database cross reference: MESH:A08.186.211.730.885.213.270
database cross reference: NCIT:C12352
database cross reference: OpenCyc:Mx4rv3OJ8JwpEbGdrcN5Y29ycA
database cross reference: UMLS:C0016733
database cross reference: UMLS:C1268977
has exact synonym: lobi frontales
has exact synonym: lobus frontalis
has_narrow_synonym: frontal cortex
has_obo_namespace: uberon
id: UBERON:0016525
in subset: efo slim

lobe of cerebral hemisphere
type: Class
subclass of: organ part
subclass of: ectoderm-derived structure
subclass of: structure with developmental contribution from neural crest
definition: Subdivision of telencephalon which is one of a number of subdivisions of each hemisphere separated by both real landmarks (sulci and fissures) and arbitrary boundaries[FMA,modified].
imported from: uberon.owl
fma_set_term: FMA_77800
has_alternative_id: UBERON:0000322
database cross reference: http://braininfo.rprc.washington.edu/centraldirectory.aspx
database cross reference: http://www.snomedbrowser.com/Codes/Details/272632001
database cross reference: BIRNLEX:922
database cross reference: BTO:0000445
database cross reference: FMA:61823
has exact synonym: cerebral hemisphere lobe
has exact synonym: cerebral lobe
has exact synonym: lobe of cerebral cortex
has exact synonym: lobe parts of cerebral cortex
has exact synonym: lobi cerebri
has_obo_namespace: uberon
has_related_synonym: cerebral cortical segment
has_related_synonym: lobes of the brain
has_related_synonym: regional organ part of cerebral cortex
has_related_synonym: segment of cerebral cortex
id: UBERON:0016526
comment: We use the term lobe broadly as a rough regional area, encompassing homologous regions in smooth-brained mammals. We subdivide the lobes into white matter and neocortical parts.

cortex of cerebral lobe
type: Class
subclass of: gray matter
subclass of: cerebral hemisphere gray matter
definition: Grey matter neocortex region of a lobe of the cerebral hemisphere.
imported from: uberon.owl
database cross reference: FMA:242197
has exact synonym: cortex of cerebral hemisphere lobe
has exact synonym: cortex of lobe of cerebral hemisphere
has_obo_namespace: uberon
has_related_synonym: gray matter of lobe of cerebral hemisphere
has_related_synonym: neocortical part of cerebral hemisphere
id: UBERON:0016529

occipital cortex
type: Class
subclass of: cortex of cerebral lobe
imported from: uberon.owl
database cross reference: DHBA:10268
database cross reference: DMBA:16030
database cross reference: EMAPA:35604
database cross reference: FMA:242205
database cross reference: MA:0000913
database cross reference: PBA:4004
has exact synonym: cortex of occipital lobe
has exact synonym: occipital lobe cortex
has exact synonym: occipital neocortex
has_obo_namespace: uberon
has_related_synonym: gray matter of occipital lobe
id: UBERON:0016540

central nervous system gray matter layer
type: Class
subclass of: nervous system cell part layer
definition: A layer of of the central nervous system that is part of gray matter.
imported from: uberon.owl
has_broad_synonym: grey matter layer
database cross reference: FMA:83142
has exact synonym: CNS gray matter layer
has exact synonym: CNS grey matter layer
has exact synonym: gray matter layer of neuraxis
has exact synonym: grey matter layer of neuraxis
has_obo_namespace: uberon
id: UBERON:0016548

gray matter of forebrain
type: Class
subclass of: brain gray matter
imported from: uberon.owl
database cross reference: DHBA:10157
database cross reference: FMA:268608
has_obo_namespace: uberon
id: UBERON:0019264

nervous system cell part layer
type: Class
subclass of: multi cell part structure
definition: Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO].
editor note: this is currently used to group some cellular layers that may not strictly conform to the CARO definition of cell-part layer. Consider genericisizing and introducing subtypes for cellular layer, fibrous layer and cell soma layer
imported from: uberon.owl
has_broad_synonym: lamina
has_broad_synonym: layer
database cross reference: NLX:149357
has_obo_namespace: uberon
id: UBERON:0022303
in subset: cumbo

posterior cingulate cortex
type: Class
subclass of: regional part of brain
subclass of: structure with developmental contribution from neural crest
definition: Component of the cingulate cortex. The rostral and caudal extent were the caudal anterior and the isthmus divisions of the cingulate cortex respectively. The medial and lateral boundaries were the corpus callosum and as the superior frontal gyrus and/or paracentral lobule respectively (Christine Fennema-Notestine).
editor note: check relationship to gyrus. See https://github.com/obophenotype/uberon/issues/626
imported from: uberon.owl
has_broad_synonym: posterior cingulate
database cross reference: Posterior cingulate
database cross reference: BIRNLEX:950
database cross reference: BTO:0004250
database cross reference: EFO:0002471
database cross reference: FMA:271593
has_obo_namespace: uberon
has_related_synonym: cingulate gyrus, posterior division
has_related_synonym: posterior cingular cortex
id: UBERON:0022353

morphological feature
type: Class
subclass of: anatomical structure
definition: A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology.
imported from: uberon.owl
has_obo_namespace: uberon
id: UBERON:0034768

cell cluster
type: Class
subclass of: multicellular anatomical structure
definition: A cluster of cells, largely surrounded by a morphological boundary.
imported from: uberon.owl
database cross reference: CARO:0020002
database cross reference: FMA:62807
has_obo_namespace: uberon
id: UBERON:0034922

zone of organ
type: Class
subclass of: organ part
imported from: uberon.owl
database cross reference: FMA:55268
has exact synonym: organ sector
has exact synonym: organ zonal region
has exact synonym: organ zone
has_obo_namespace: uberon
has_related_synonym: organ region with floating fiat boundary
id: UBERON:0034944

functional part of brain
type: Class
subclass of: regional part of brain
definition: A brain region defined by functional criteria, e.g. auditory cortex, rather than by structural or histological criteria.
imported from: uberon.owl
database cross reference: NLX:155513
has_obo_namespace: uberon
id: UBERON:0035014

mossy fiber
type: Class
subclass of: tissue
subclass of: ectoderm-derived structure
subclass of: structure with developmental contribution from neural crest
imported from: uberon.owl
provenance_notes: This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon
database cross reference: ZFA:0001710
has_obo_namespace: uberon
id: UBERON:2002210

parallel fiber
type: Class
subclass of: tissue
subclass of: ectoderm-derived structure
subclass of: structure with developmental contribution from neural crest
imported from: uberon.owl
provenance_notes: This class was sourced from an external ontology (teleost_anatomy). Its definitions, naming conventions and relationships may need to be checked for compatibility with uberon
database cross reference: ZFA:0001713
has exact synonym: parallel fibers
has_obo_namespace: uberon
id: UBERON:2002218

metabolism
type: Class
subclass of: biological_process
definition: The totality of the chemical reactions and physical changes that occur in living organisms, comprising anabolism and catabolism; may be qualified to mean the chemical reactions and physical processes undergone by a particular substance, or class of substances, in a living organism. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
imported from: upa.owl
database cross reference: GO:0008152
has_obo_namespace: pathway
id: UPa:UPA00026

energy metabolism
type: Class
subclass of: metabolism
definition: The chemical reactions involved in energy transformations within cells. .
imported from: upa.owl
database cross reference: GO:0006091
database cross reference: GO:0006112
has_obo_namespace: pathway
id: UPa:UPA00426

protein degradation
type: Class
subclass of: metabolism
definition: Degradation of cellular proteins.
imported from: upa.owl
database cross reference: GO:0044257
has_obo_namespace: pathway
has_related_synonym: proteolysis
id: UPa:UPA00468

diacylglycerol
type: Class
subclass of: lipid
subclass of: chalcogen molecular entity
subclass of: organic molecule
imported from: upa.owl
database cross reference: CHEBI:18035
database cross reference: KEGG:C00165
has_obo_namespace: compound
id: UPa:UPC00165

dimethylallyl diphosphate
type: Class
subclass of: organophosphorus compound
subclass of: chalcogen molecular entity
imported from: upa.owl
database cross reference: CHEBI:16057
database cross reference: KEGG:C00235
has_obo_namespace: compound
has_related_synonym: C5H12O7P2
has_related_synonym: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)
has_related_synonym: dimethylallyl-PP
id: UPa:UPC00235

tetrahydrobiopterin
type: Class
subclass of: chalcogen molecular entity
subclass of: organic hydroxy compound
subclass of: organonitrogen compound
imported from: upa.owl
database cross reference: CHEBI:15372
database cross reference: CHEBI:59560
database cross reference: KEGG:C00272
has_obo_namespace: compound
has_related_synonym: C9H15N5O3
has_related_synonym: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4+,6-/m0/s1
id: UPa:UPC00272

mouse gene
type: Class
subclass of: gene
definition editor: YH
imported from: vo.owl

ionotropic glutamate receptor antagonist
type: Class
subclass of: inhibitor
definition: Any condition in which the main influencing factor is an agent that blocks the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
imported from: xco.owl
created by: slaulede
creation date: 2019-12-16T17:38:36Z
has_obo_namespace: experimental_condition_ontology
id: XCO:0000653

performing physical activity
type: Class
subclass of: non-pharmacotherapy procedure
from Alzheimer Ontology: true

non-pharmacotherapy procedure
type: Class
subclass of: therapeutic procedure
from Alzheimer Ontology: true