format-version: 1.2
data-version: release/2019-10-28
ontology: xlmod
date: 23:03:2021 20:08
saved-by: Paul Thomas
auto-generated-by: OBO-Edit 2.3.1
default-namespace: XLMOD
remark: version: 1.1.12
remark: coverage: cross-linking reagents, cross-linker related post-translational modifications, and derivatization reagents for GC-MS and LC-MS
remark: creator: Lutz Fischer <lfischer <-at-> staffmail.ed.ac.uk>
remark: creator: Alexander Leitner <leitner <-at-> imsb.biol.ethz.ch>
remark: creator: Nils Hoffmann <nils.hoffmann <-at-> isas.de>
remark: creator: Gerhard Mayer <mayerg97 <-at-> rub.de>
remark: This work is licensed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.
remark: To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ or send a letter to Creative Commons, 444 Castro Street, Suite 900, Mountain View, California, 94041, USA.

[Typedef]
id: part_of
name: part_of
is_transitive: true
def: "The basic part of relationship indicating a top-level branch of this ontology." [OBO:defs]

[Typedef]
id: is_activatable
name: is_activatable
def: "Indicates how the cross-linking reagent can be activated." [OBO:defs]

[Typedef]
id: is_analog_of
name: is_analog_of
def: "Indicates biochemical analogues of nucleobases, nucleosides or amino acids." [OBO:defs]

[Typedef]
id: is_cleavable
name: is_cleavable
def: "Indicates that the cross-linking reagent is cleavable." [OBO:defs]

[Typedef]
id: is_labelled
name: is_labelled
def: "Indicates that the cross-linking or derivatization reagent has an isotopic label." [OBO:defs]

[Typedef]
id: is_partially_reacted
name: is_partially_reacted
def: "Specifies the type of the cross-linker related chemical modification." [OBO:defs]

[Typedef]
id: is_reactive_with
name: is_reactive_with
def: "Indicates the chemical group that can react with the cross-linking or derivatization reagent." [OBO:defs]

[Typedef]
id: is_side_product_of
name: is_side_product_of
def: "Indicates the cross-linking reagent from which the chemical modification is derived." [OBO:defs]

[Typedef]
id: has_handle
name: has_handle
def: "Indicates that the cross-linking reagent has a handle that can be used for detection/identification, enrichment or purification." [OBO:defs]

[Typedef]
id: has_click_enabled_linker
name: has_click_enabled_linker
def: "Indicates that the cross-linking reagent has a linker that can be enabled by click chemistry." [OBO:defs]

[Typedef]
id: has_neutral_loss_reporter
name: has_neutral_loss_reporter
def: "Indicates that the cross-linking reagent has a neutral loss reporter." [OBO:defs]

[Typedef]
id: has_property
name: has_property
def: "Indicates a property of a cross-linking or derivatization reagent." [OBO:defs]

[Typedef]
id: has_chromophore
name: has_chromophore
def: "Indicates that the derivatization reagent can be detected by the specified chromophore." [OBO:defs]

[Typedef]
id: has_electrophore
name: has_electrophore
def: "Indicates that the derivatization reagent can be detected by the specified electrophore." [OBO:defs]

[Typedef]
id: has_fluorophore
name: has_fluorophore
def: "Indicates that the derivatization reagent can be detected by the specified fluorophore." [OBO:defs]

[Typedef]
id: has_reactive_group
name: has_reactive_group
def: "Indicates that the cross-linking or derivatization reagent has the specified reactive group." [OBO:defs]

[Term]
id: XLMOD:00000
name: Proteomics Standards Initiative cross-linking and derivatization controlled vocabulary
def: "Proteomics Standards Initiative cross-linking and derivatization controlled vocabulary." [PSI:XL]

[Term]
id: XLMOD:00001
name: cross-linking entity
def: "Entity relevant to the domain of cross-linking in proteomics." [PSI:XL]
relationship: part_of XLMOD:00000 ! Proteomics Standards Initiative cross-linking and derivatization controlled vocabulary

[Term]
id: XLMOD:00002
name: cross-linker related chemical modification
def: "Dead-end modification resulting from a cross-linker reagent reacting only with one peptide." [PSI:XL]
relationship: part_of XLMOD:00000 ! Proteomics Standards Initiative cross-linking and derivatization controlled vocabulary

[Term]
id: XLMOD:00003
name: label transfer reagent
def: "A cross-linker acting as label transfer reagent." [PSI:XL]
relationship: part_of XLMOD:00000 ! Proteomics Standards Initiative cross-linking and derivatization controlled vocabulary

[Term]
id: XLMOD:00004
name: cross-linker
def: "Compound that can link two or more polymer chains." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00005
name: homofunctional cross-linker
def: "A cross-linking reagent with identical reactive groups at each end of the spacer arm." [PSI:XL]
is_a: XLMOD:00004 ! cross-linker

[Term]
id: XLMOD:00006
name: heterofunctional cross-linker
def: "A cross-linking reagent with at least two different reactive groups." [PSI:XL]
is_a: XLMOD:00004 ! cross-linker

[Term]
id: XLMOD:00007
name: photoreactive cross-linker
def: "OBSOLETE A cross-linking reagent that becomes reactive when exposed to ultraviolet or visible light." [PSI:XL]
comment: This term was made obsolete because photo-reactivity is now encoded for the reactive groups of the cross-linkers, see (XLMOD:00108).
is_obsolete: true

[Term]
id: XLMOD:00008
name: zero-length cross-linker
def: "A cross-linking reagent causing direct conjugation without becoming part of the final cross-link between the target molecules." [PSI:XL]
is_a: XLMOD:00004 ! cross-linker

[Term]
id: XLMOD:00009
name: cross-linking attribute
def: "An attribute describing a cross-linker." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00010
name: deuterium labelled
def: "Indicates that a cross-linker is deuterium labelled." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00011
name: hydrolyzed
def: "Indicates that a cross-linker is hydrolyzed, for example for NHS-type reagents -C(=O)-NHS was converted to -C(=O)-OH." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00012
name: amidated
def: "Indicates that a cross-linker is amidated." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00013
name: membrane permeable
def: "Indicates that a cross-linker is membrane permeable." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00014
name: hydrophilic
def: "Indicates that a cross-linker is hydrophilic." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00015
name: fluorescent
def: "Indicates that a cross-linker is fluorescent." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00016
name: cleavable
def: "Indicates that a cross-linker is cleavable." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00017
name: chemically cleavable
def: "Indicates that a cross-linker is chemically cleavable." [PSI:XL]
is_a: XLMOD:00016 ! cleavable

[Term]
id: XLMOD:00018
name: cleavable by MS2 labile bond
def: "Indicates that a cross-linker is mass-spectrometrically cleavable, i.e. contains a MS2 labile bond leading to fragments detected in MS3." [PSI:XL]
is_a: XLMOD:00016 ! cleavable

[Term]
id: XLMOD:00019
name: enrichable
def: "Indicates that a cross-linker facilitates enrichment." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00020
name: iodinatable
def: "Indicates that a cross-linker is iodinatable, e.g. for autoradiographic detection by radio-labelling with J-131." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00021
name: ammonium amidated
def: "Indicates a dead-end modification that was amidated by an ammonium salt, like e.g. bicarbonate, phosphate, chloride, for example for NHS-type reagents -C(=O)-NHS was converted to -C(=O)-NH2." [PSI:XL]
is_a: XLMOD:00012 ! amidated

[Term]
id: XLMOD:00022
name: Tris amidated
def: "Indicates a dead-end modification that was amidated by Tris(hydroxymethyl)-aminomethane, for example for NHS-type reagents -C(=O)-NHS was converted to -C(=O)-NHC(CH2OH)3." [PSI:XL]
is_a: XLMOD:00012 ! amidated

[Term]
id: XLMOD:00023
name: cleavable S-S bond
def: "Indicates that a cross-linker contains a cleavable S-S bond, which is chemically cleavable by reducing agents like e.g. thiols, beta-mercaptoethanol, dithiothreitol (DTT), mercaptomethylamine or Tris(2-carboxyethyl)phosphin (TCEP)." [PSI:XL]
is_a: XLMOD:00017 ! chemically cleavable
relationship: is_cleavable XLMOD:00041 ! thiol cleavable
relationship: is_cleavable XLMOD:00038 ! DTT cleavable
relationship: is_cleavable XLMOD:00042 ! TCEP cleavable
relationship: is_cleavable XLMOD:00043 ! mercaptoethanol cleavable

[Term]
id: XLMOD:00024
name: periodate cleavable
def: "Indicates that a cross-linker is chemically cleavable by the oxidizing agent periodate." [PSI:XL]
is_a: XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:00025
name: hydroxylamine cleavable
def: "Indicates that a cross-linker is chemically cleavable by hydroxylamine." [PSI:XL]
is_a: XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:00026
name: reactive group attribute
def: "An attribute describing a reactive group." [PSI:XL]
relationship: part_of XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00027
name: chemically reactive
def: "Indicates that a reactive group reacts with specific functional groups." [PSI:XL]
is_a: XLMOD:00026 ! reactive group attribute

[Term]
id: XLMOD:00028
name: primary amine reactive
def: "Indicates that a reactive group is reactive with primary amino (-NH2) groups." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00029
name: sulfhydryl reactive
def: "Indicates that a reactive group is reactive with sulfhydryl (-SH) groups." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00030
name: carboxyl reactive
def: "Indicates that a reactive group is reactive with carboxyl (-COOH) groups." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00031
name: aldehyde reactive
def: "Indicates that a reactive group is reactive with aldehyde (-CHO) or carbonyl (-CO) groups." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00032
name: hydroxyl reactive
def: "Indicates that a reactive group is reactive with hydroxyl (-OH) groups." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00033
name: azide reactive
def: "Indicates that a reactive group is reactive with azide (-N3) groups." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00034
name: photo cleavable
def: "Indicates that a cross-linker is cleavable by light." [PSI:XL]
is_a: XLMOD:00016 ! cleavable

[Term]
id: XLMOD:00035
name: CID cleavable
def: "Indicates that a cross-linker is mass-spectrometrically cleavable by collission induced dissociation." [PSI:XL]
is_a: XLMOD:00016 ! cleavable

[Term]
id: XLMOD:00036
name: 13C labelled
def: "Indicates that a cross-linker is labelled with carbon-13." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00037
name: non-selective
def: "Indicates that a cross-linker is non-selective (i.e. can react with different amino acids, but also with DNA/RNA and carbohydrates (aldehyde reactive))." [PSI:XL]
is_a: XLMOD:00026 ! reactive group attribute

[Term]
id: XLMOD:00038
name: DTT cleavable
def: "Indicates that a cross-linker is chemically cleavable by the reducing agent DTT (dithiothreitol)." [PSI:XL]
is_a: XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:00039
name: ammonium cleavable
def: "Indicates that a cross-linker is chemically cleavable by ammonium hydroxide." [PSI:XL]
is_a: XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:00040
name: ISD cleavable
def: "Indicates that a cross-linker is mass-spectrometrically cleavable by in-source decay." [PSI:XL]
is_a: XLMOD:00016 ! cleavable

[Term]
id: XLMOD:00041
name: thiol cleavable
def: "Indicates that a cross-linker is mass-spectrometrically cleavable (reducible) by thiols." [PSI:XL]
synonym: "DTT cleavable" RELATED []
synonym: "TCEP cleavable" RELATED []
synonym: "mercaptoethanol cleavable" RELATED []
is_a: XLMOD:00016 ! cleavable

[Term]
id: XLMOD:00042
name: TCEP cleavable
def: "Indicates that a cross-linker is chemically cleavable by the reducing agent TCEP (Tris(2-carboxyethyl)phosphin)." [PSI:XL]
is_a: XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:00043
name: mercaptoethanol cleavable
def: "Indicates that a cross-linker is chemically cleavable by the reducing agent mercaptoethanol." [PSI:XL]
is_a: XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:00044
name: mass defect labelled
def: "Indicates that a cross-linker is mass defect labelled." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00045
name: thioether reactive
def: "Indicates that a reactive group is reactive with thioether (R1-S-R2) groups." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00046
name: imidazole reactive
def: "Indicates that a reactive group is reactive with the heterocyclic imidazole groups." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00047
name: thioesterized
def: "Indicates that a cross-linker is thioesterized." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00048
name: nucleic acid reactive
def: "Indicates that a reactive group is reactive with RNA or DNA." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00049
name: amino acid derivative
def: "An amino acid derivative used in cross-linking experiments." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00050
name: handle
def: "A handle attached to a cross-linker used for detection, affinity enrichment or purification." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity
relationship: part_of XLMOD:00004 ! cross-linker

[Term]
id: XLMOD:00051
name: biotin
def: "A Biotin affinity handle, enrichable with avidin, streptavidin or neutravidin, attached to a cross-linker." [PSI:XL]
is_a: XLMOD:00050 ! handle
is_a: XLMOD:00019 ! enrichable

[Term]
id: XLMOD:00052
name: NO2 neutral loss reporter
def: "A NO2 detection tag." [PMID:19496583]
is_a: XLMOD:00050 ! handle

[Term]
id: XLMOD:00053
name: alkyne
def: "An alkyne (hadrocarbon with at least one C-C triple bond) tag, e.g. BARAC (biarylazacycloctynone) to enable enrichment of cross-linked peptides by either coupling of an affinity group with alkyne-azido click chemistry or by using immobilized azide linkers." [PMID:19496583]
is_a: XLMOD:00050 ! handle
is_a: XLMOD:00019 ! enrichable

[Term]
id: XLMOD:00054
name: DNB
def: "A dinitrobenzole affinity handle for enrichment with anti-DNB antibodies, attached to a cross-linker." [PSI:XL]
is_a: XLMOD:00050 ! handle
is_a: XLMOD:00019 ! enrichable

[Term]
id: XLMOD:00055
name: azide
def: "A photoreactive azide (-N3) tag to enable enrichment of cross-linked peptides with either immobilized alkyne linkers or by azide-alkyne click chemistry using biotin-alkyne respective biotin-phosphine." [PMID:20472459]
is_a: XLMOD:00050 ! handle
is_a: XLMOD:00019 ! enrichable
is_a: XLMOD:00100 ! reactive group
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00056
name: CHCA
def: "An alpha-cyano-4-hydroxycinnamic acid UV-absorbing label for signal enhancement." [PMID:19902427]
is_a: XLMOD:00050 ! handle

[Term]
id: XLMOD:00057
name: generic neutral loss reporter
def: "A generic neutral loss reporter." [PXI:XL]
is_a: XLMOD:00050 ! handle

[Term]
id: XLMOD:00058
name: amino acid
def: "An amino acid compound." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00059
name: L-Leucine
def: "The amino acid L-Leucine." [PXI:XL]
is_a: XLMOD:00058 ! amino acid

[Term]
id: XLMOD:00060
name: L-Methionine
def: "The amino acid L-Methionine." [PXI:XL]
is_a: XLMOD:00058 ! amino acid

[Term]
id: XLMOD:00061
name: base cleavable
def: "Indicates that a cross-linker is chemically cleavable by bases." [PSI:XL]
is_a: XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:00062
name: hydrazine reactive
def: "Indicates that a reactive group is reactive with hydrazines (N2H4)." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00063
name: carbonyl reactive
def: "Indicates that a reactive group is reactive with carbonyl (R1-CO-R2) groups." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00064
name: oxidized
def: "Indicates that a cross-linker is oxidized, e.g. by oxidizing a carbonyl to a carboxyl functional group." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00065
name: alkenized
def: "Indicates that a cross-linker is modified to it's alkene form (loss of two hydrogen atoms by forming a C=C double bond)." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00066
name: acid cleavable
def: "Indicates that a cross-linker is chemically cleavable by acids." [PSI:XL]
is_a: XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:00067
name: CID cleavable C-S bond
def: "Indicates that a cross-linker contains a CID (Collision Induced Dissociation) cleavable C-S bond." [PSI:XL]
is_a: XLMOD:00035 ! CID cleavable
relationship: is_cleavable XLMOD:00018 ! cleavable by MS2 labile bond

[Term]
id: XLMOD:00068
name: L-Isoleucine
def: "The amino acid L-Isoleucine." [PXI:XL]
is_a: XLMOD:00058 ! amino acid

[Term]
id: XLMOD:00069
name: 18O labelled
def: "Indicates that a cross-linker is labelled with oxygen-18." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00070
name: L-Phenylalanine
def: "The amino acid L-Phenylalanine." [PXI:XL]
is_a: XLMOD:00058 ! amino acid

[Term]
id: XLMOD:00071
name: iminobiotintrifluoroacetamide
def: "A Iminobiotin trifluoroacetamide affinity handle, enrichable with avidin, streptavidin or neutravidin, attached to a cross-linker." [PSI:XL]
is_a: XLMOD:00050 ! handle
is_a: XLMOD:00019 ! enrichable
relationship: is_reactive_with XLMOD:00072 ! avidin reactive

[Term]
id: XLMOD:00072
name: avidin reactive
def: "Indicates that a reactive group is reactive with either of the glycoproteins avidin, streptavidin or neutravidin." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:00073
name: nucleobase
def: "A nitrogeneous base occurring in nucleic acids." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00074
name: purine base
def: "A purine base occurring in nucleic acids." [PSI:XL]
is_a: XLMOD:00073 ! nucleobase

[Term]
id: XLMOD:00075
name: pyrimidine base
def: "A pyrimidine base occurring in nucleic acids." [PSI:XL]
is_a: XLMOD:00073 ! nucleobase

[Term]
id: XLMOD:00076
name: adenine
def: "The nucleobase adenine." [PXI:XL]
is_a: XLMOD:00074 ! purine base

[Term]
id: XLMOD:00077
name: guanine
def: "The nucleobase guanine." [PXI:XL]
is_a: XLMOD:00074 ! purine base

[Term]
id: XLMOD:00078
name: cytosine
def: "The nucleobase cytosine." [PXI:XL]
is_a: XLMOD:00075 ! pyrimidine base

[Term]
id: XLMOD:00079
name: thymine
def: "The nucleobase thymine." [PXI:XL]
is_a: XLMOD:00075 ! pyrimidine base

[Term]
id: XLMOD:00080
name: uracil
def: "The nucleobase uracil." [PXI:XL]
is_a: XLMOD:00075 ! pyrimidine base

[Term]
id: XLMOD:00081
name: nucleobase derivative
def: "A nucleobase derivative used in cross-linking experiments for protein-oligonucleotide cross-linking." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity
relationship: is_analog_of XLMOD:00073 ! nucleobase

[Term]
id: XLMOD:00082
name: nucleoside
def: "A combination of a nucleobase and a sugar (either ribose or deoxyribose)." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00083
name: adenosine
def: "The nucleoside adenosine." [PXI:XL]
is_a: XLMOD:00082 ! nucleoside

[Term]
id: XLMOD:00084
name: guanosine
def: "The nucleoside guanosine." [PXI:XL]
is_a: XLMOD:00082 ! nucleoside

[Term]
id: XLMOD:00085
name: cytidine
def: "The nucleoside cytidine." [PXI:XL]
is_a: XLMOD:00082 ! nucleoside

[Term]
id: XLMOD:00086
name: uridine
def: "The nucleoside uridine." [PXI:XL]
is_a: XLMOD:00082 ! nucleoside

[Term]
id: XLMOD:00087
name: 5-methyluridine
def: "The nucleoside 5-methyluridine." [PXI:XL]
is_a: XLMOD:00082 ! nucleoside

[Term]
id: XLMOD:00088
name: nucleoside derivative
def: "A nucleoside derivative used in cross-linking experiments for protein-oligonucleotide cross-linking." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity
relationship: is_analog_of XLMOD:00082 ! nucleoside

[Term]
id: XLMOD:00089
name: RNA-SH
def: "Thiol-modified RNA." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00090
name: biotin-alkyne
def: "A biotin-alkyne affinity handle, which can be used for enrichment with click-chemistry." [PSI:XL]
is_a: XLMOD:00050 ! handle
is_a: XLMOD:00019 ! enrichable
relationship: is_reactive_with XLMOD:00033 ! azide reactive

[Term]
id: XLMOD:00091
name: tetramethylrhodamine-alkyne
def: "A tetramethylrhodamine-alkyne affinity handle, which can be used for enrichment with click-chemistry." [PSI:XL]
synonym: "TAMRA" EXACT []
is_a: XLMOD:00050 ! handle
is_a: XLMOD:00019 ! enrichable
relationship: is_reactive_with XLMOD:00033 ! azide reactive

[Term]
id: XLMOD:00092
name: lipid analogue
def: "A lipid analogue used in cross-linking experiments for lipid-protein cross-linking." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00093
name: sialic acid analogue
def: "A sialic acid analogue used in cross-linking experiments for glycan-protein cross-linking." [PSI:XL]
is_a: XLMOD:00001 ! cross-linking entity

[Term]
id: XLMOD:00094
name: alkenized cross-linker related chemical modification
def: "Alkenization dead-end modification resulting from a cross-linker reagent reacting only with one peptide." [PSI:XL]
is_a: XLMOD:00002 ! cross-linker related chemical modification

[Term]
id: XLMOD:00095
name: ammonium amidation cross-linker related chemical modification
def: "Ammonium amidation dead-end modification resulting from a cross-linker reagent reacting only with one peptide." [PSI:XL]
is_a: XLMOD:00002 ! cross-linker related chemical modification

[Term]
id: XLMOD:00096
name: hydrolization cross-linker related chemical modification
def: "Hydrolization dead-end modification resulting from a cross-linker reagent reacting only with one peptide." [PSI:XL]
is_a: XLMOD:00002 ! cross-linker related chemical modification

[Term]
id: XLMOD:00097
name: oxidation cross-linker related chemical modification
def: "Oxidition dead-end modification resulting from a cross-linker reagent reacting only with one peptide." [PSI:XL]
is_a: XLMOD:00002 ! cross-linker related chemical modification

[Term]
id: XLMOD:00098
name: thioesterization cross-linker related chemical modification
def: "Thio-esterization dead-end modification resulting from a cross-linker reagent reacting only with one peptide." [PSI:XL]
is_a: XLMOD:00002 ! cross-linker related chemical modification

[Term]
id: XLMOD:00099
name: formic acid cleavable
def: "Indicates that a cross-linker is chemically cleavable by formic acid." [PSI:XL]
is_a: XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:00100
name: reactive group
def: "Part of a cross-linker that reacts with the amino-acids of the protein." [PSI:XL]
is_a: XLMOD:00009 ! cross-linking attribute

[Term]
id: XLMOD:00101
name: NHS ester
def: "A reactive group (N-hydroxysuccinimide) that reacts with lysines and N-termini but also serines, threonines and tyrosines." [PSI:XL]
synonym: "N-hydroxysuccinimide ester" EXACT []
property_value: specificities: "(K,Protein N-term)" xsd:string
property_value: secondarySpecificities: "(S,T,Y)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00102
name: Sulfo NHS ester
def: "A reactive group (N-hydroxysulfosuccinimide) that reacts with lysines and N-termini but also serines, threonines and tyrosines." [PSI:XL]
synonym: "N-hydroxysulfosuccinimide ester" EXACT []
property_value: specificities: "(K,Protein N-term)" xsd:string
property_value: secondarySpecificities: "(S,T,Y)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00103
name: diazirine
def: "Photoreactive group (R1-CN2-R2) that inserts into any C-H or N-H bond." [PSI:XL]
property_value: waveLengthRange: "330-370 nm" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00104
name: N-hydroxyphthalimide
def: "A reactive group that reacts with amines." [PMID:19994840]
property_value: specificities: "(K,N,Q,R,Protein N-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00105
name: carbodiimide
def: "A Carboxyl-to-amine (R1-N=C=N_R2) reactive chemical group." [PSI:XL]
property_value: specificities: "(K,N,Q,R,Protein N-term)&(E,D,Protein C-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:00106
name: maleimide
def: "A reactive group that reacts with sulfhydryl groups." [PSI:XL]
property_value: specificities: "(C)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive

[Term]
id: XLMOD:00107
name: nitrophenyl azide
def: "A nitrophenyl azide photoreactive group." [PSI:XL]
property_value: waveLengthRange: "320-370 nm" xsd:string
is_a: XLMOD:00114 ! aryl azide
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00037 ! non-selective
relationship: is_reactive_with XLMOD:00089 ! RNA-SH

[Term]
id: XLMOD:00108
name: photoreactive
def: "Indicates that a reactive group is photoreactive." [PSI:XL]
is_a: XLMOD:00026 ! reactive group attribute

[Term]
id: XLMOD:00109
name: pyridinyldisulfide
def: "A pyridinyldisulfide reactive group that reacts with sulfhydryl groups to form disulfide bonds." [PSI:XL]
synonym: "pyridyl disulfide" EXACT []
synonym: "pyridyldithiol" EXACT []
property_value: specificities: "(C)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive

[Term]
id: XLMOD:00110
name: hydrazide
def: "A hydrazide reactive group (-CO-NH-NH2) that reacts with carbonyls to form hydrazone bonds." [PSI:XL]
property_value: specificities: "(D,E,Protein C-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:00111
name: imidoester
def: "An amine-reactive chemical group (R1-C(=NH)-OR2)." [PSI:XL]
property_value: specificities: "(K,N,Q,R,Protein N-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00112
name: haloacetyl
def: "A reactive group (alpha-haloacetyl, halo-C2H5), mostly a iodoacetyl, bromoacetyl or chloroacetyl group, that reacts with sulfhydryl groups." [PSI:XL]
property_value: specificities: "(C)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive

[Term]
id: XLMOD:00113
name: alkoxyamine
def: "A reactive group (R-O-N-R2) that conjugates to carbonyls." [PSI:XL]
property_value: specificities: "(D,E,Protein C-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive

[Term]
id: XLMOD:00114
name: aryl azide
def: "Photoreactive aryl(Ar)-substitited azide (N=N=N) group, that initiates addition reactions with double bonds or insertion into C-H and N-H bonds or reacts with primary amines." [PSI:XL]
property_value: waveLengthRange: "250-350 nm" xsd:string
is_a: XLMOD:00055 ! azide
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00115
name: glyoxal
def: "An arginine-specific reactive group (H-CO-CO-H)." [PSI:XL]
property_value: baseSpecificities: "(Guanine)" xsd:string
property_value: specificities: "(R)" xsd:string
is_a: XLMOD:00100 ! reactive group

[Term]
id: XLMOD:00116
name: aldehyde group
def: "An aldehyde (R-CO-H) reactive group." [PSI:XL]
property_value: specificities: "(K,N,R,Q,Y,Protein N-term)" xsd:string
property_value: secondarySpecificities: "(C,F,H,S,T,W)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00117
name: acryl
def: "A reactive group (CH2=CH-CO-R) that reacts with sulfhydryl (-SH) groups." [PMID:22641729]
property_value: specificities: "(C)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive

[Term]
id: XLMOD:00118
name: tetrafluorophenyl azide
def: "Tetrafluorophenyl (TFP) azide (N=N=N) photoreactive group." [PMID:22641729]
is_a: XLMOD:00114 ! aryl azide
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00119
name: benzophenone
def: "Benzophenone photoreactive group." [PMID:22641729]
property_value: waveLengthRange: "350-360 nm" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00037 ! non-selective
relationship: is_reactive_with XLMOD:00089 ! RNA-SH

[Term]
id: XLMOD:00120
name: pentafluorophenyl
def: "A reactive group (F5-Ph) that reacts with amines." [PMID:22067100]
synonym: "PFP ester" EXACT []
property_value: specificities: "(K,N,Q,R,Protein N-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00121
name: methanethiosulfonate
def: "A reactive group (Ch3-SO2-S-R) that reacts with sulfhydryl (-SH) groups." [PSI:XL]
synonym: "MTS" EXACT []
property_value: specificities: "(C)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive

[Term]
id: XLMOD:00122
name: 4-azido-2,3,5,6-tetrafluorobenzene
def: "Photoreactive group that inserts into any C-H bond." [PSI:XL]
synonym: "ATFB" EXACT []
property_value: waveLengthRange: "UV" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00123
name: thermoreactive
def: "Indicates that a reactive group is thermoreactive." [PSI:XL]
is_a: XLMOD:00026 ! reactive group attribute

[Term]
id: XLMOD:00124
name: isocyanate
def: "An isocyanate (-N=C=O) that reacts with hydroxyl groups." [PMID:21557289]
property_value: specificities: "(S,T,Y)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06500 ! secondary amine reactive

[Term]
id: XLMOD:00125
name: hydroxyphenyl azide
def: "A hydroxyphenyl azid photoreactive group." [PSI:XL]
property_value: waveLengthRange: "320-350 nm" xsd:string
is_a: XLMOD:00114 ! aryl azide
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00126
name: phenyl azide
def: "A phenyl azide photoreactive group." [PSI:XL]
synonym: "aryl nitrene" EXACT []
property_value: waveLengthRange: "320-350 nm" xsd:string
is_a: XLMOD:00114 ! aryl azide
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00127
name: iodoacetyl
def: "A iodoacetyl reactive group, that reacts with sulfhydryl groups." [PSI:XL]
property_value: specificities: "(C,H)" xsd:string
is_a: XLMOD:00112 ! haloacetyl
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive

[Term]
id: XLMOD:00128
name: bromoacetyl
def: "A bromoacetyl reactive group, that reacts with sulfhydryl groups." [PSI:XL]
property_value: specificities: "(C,H)" xsd:string
is_a: XLMOD:00112 ! haloacetyl
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive

[Term]
id: XLMOD:00129
name: hydroxybenzotriazole
def: "A reactive group that reacts with amines." [PMID:19994840]
property_value: specificities: "(K,N,Q,R,Protein N-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00130
name: 1-hydroxy-7-azabenzotriazole
def: "A reactive group that reacts with amines." [PMID:19994840]
property_value: specificities: "(K,N,Q,R,Protein N-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00131
name: thioimidate
def: "A reactive group that reacts with amines." [PMID:20795639]
property_value: specificities: "(K,N,Q,R,Protein N-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00132
name: platinum(II)
def: "Platinum(II) coordinates with the side chains of methionine (Met), cysteine (Cys), and histidine(His), namely, thioether, sulfhydryl, and imidazole." [PMID:21591778]
property_value: baseSpecificities: "(Guanine)" xsd:string
property_value: secondaryBaseSpecificities: "(Adenine, Cytosine)" xsd:string
property_value: specificities: "(C,H,M)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive
relationship: is_reactive_with XLMOD:00045 ! thioether reactive
relationship: is_reactive_with XLMOD:00046 ! imidazole reactive

[Term]
id: XLMOD:00133
name: amine reactive group
def: "Reactive group (-NH2) that reacts with carboxyl (-COOH) groups." [PSI:XL]
property_value: specificities: "(D,E)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:00134
name: psoralen
def: "A photoreactive group that reacts with pyrimidines, especially thymines of nucleic acids." [PSI:XL]
property_value: specificities: "(Thy)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00048 ! nucleic acid reactive

[Term]
id: XLMOD:00135
name: azido-methylcoumarin
def: "A photoreactive azido-methylcoumarin group." [PSI:XL]
is_a: XLMOD:00100 ! reactive group
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00136
name: perfluoroaryl azide
def: "A photoreactive perfluoroaryl azide group." [PSI:XL]
is_a: XLMOD:00114 ! aryl azide
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00137
name: diazo group
def: "A photoreactive diazo (R1R2C=N=N) group." [PSI:XL]
is_a: XLMOD:00100 ! reactive group
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00138
name: carboxyl
def: "A reactive group (-COOH) that reacts with primary amine (-NH2) groups." [PSI:XL]
property_value: specificities: "(K,N,Q,R,Protein N-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00139
name: hydroxymethyl phosphine
def: "A reactive group that reacts with amine groups." [PSI:XL]
property_value: specificities: "(K,N,Q,R,Protein N-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00140
name: vinyl sulfone
def: "A reactive group that reacts with hydroxyl groups." [PSI:XL]
property_value: specificities: "(C,K,N,Q,R,S,T,Y)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive

[Term]
id: XLMOD:00141
name: carbonyl
def: "A reactive group (C=O)that reacts with hydrazines (N2H4)." [PSI:XL]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00062 ! hydrazine reactive

[Term]
id: XLMOD:00142
name: phenylglyoxal
def: "An arginine-specific reactive group." [PSI:XL]
property_value: specificities: "(R)" xsd:string
is_a: XLMOD:00115 ! glyoxal

[Term]
id: XLMOD:00143
name: hydrazone
def: "A hydrazone reactive group (C=NH-NHR) that reacts with carbonyls." [PSI:XL]
property_value: specificities: "(D,E,Protein C-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive

[Term]
id: XLMOD:00144
name: S-acetyl
def: "A S-acetyl group." [PSI:XL]
comment: Used to incorporate sulfhydryl (-SH) groups into proteins as part of a two-step or heterobifunctional crosslinking strategy.
synonym: "SAT" EXACT []
is_a: XLMOD:00100 ! reactive group

[Term]
id: XLMOD:00145
name: aryl halide
def: "An aryl halide group (Ar-halogen) that reacts with primary amines." [PSI:XL]
property_value: specificities: "(K,N,Q,R,Protein N-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00146
name: dimethylether
def: "A dimethylether (Ch3-O-CH3) reactive group that reacts with carboxyl groups." [PSI:XL]
property_value: specificities: "(D,E)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:00147
name: photocleavable
def: "Indicates that a reactive group is photocleavable." [PSI:XL]
is_a: XLMOD:00108 ! photoreactive

[Term]
id: XLMOD:00148
name: nitrobenzylester
def: "A photocleavable group." [PSI:XL]
is_a: XLMOD:00100 ! reactive group
relationship: is_cleavable XLMOD:00147 ! photocleavable
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:00149
name: photoactivatable
def: "Indicates that a reactive group is photoactivatable." [PSI:XL]
is_a: XLMOD:00108 ! photoreactive

[Term]
id: XLMOD:00150
name: tetrafluorophenyl ester
def: "Tetrafluorophenyl (TFP, F4-Ph) ester." [PMID:22641729]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00151
name: pentylamine
def: "A pentylamine (CH3(CH2)4-NH2) reactive group that reacts with carboxyl groups." [PSI:XL]
property_value: specificities: "(D,E)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:00152
name: Biotin
def: "A biotin reactive group that reacts with avidin, streptavidin or neutravidin." [PSI:XL]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00072 ! avidin reactive

[Term]
id: XLMOD:00153
name: chloroethyl
def: "A reactive group that reacts with guanin." [PSI:XL]
is_a: XLMOD:00100 ! reactive group
property_value: baseSpecificities: "(Guanine)" xsd:string
property_value: secondaryBaseSpecificities: "(Adenine, Cytosine)" xsd:string

[Term]
id: XLMOD:00154
name: imino
def: "An imino (R1R2-C=N-R3) reactive group that reacts with primary amines." [PSI:XL]
property_value: specificities: "(D,E,K,Protein N-term)" xsd:string
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00155
name: acyl chloride
def: "An acyl chloride (R-CO-Cl) reactive group that reacts with alcohol, phenol, thiol and amines." [PMID:21557289]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06500 ! secondary amine reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:00156
name: sulfonyl chloride
def: "A sulfonyl chloride (R-SO2-Cl) reactive group." [PMID:21557289]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06500 ! secondary amine reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:00157
name: benzofurazan
def: "A benzofurazan (2,1,3-benzoxadiazole) reactive group." [PMID:21557289]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:00158
name: halobenzofurazan
def: "A halobenzofurazan (2,1,3-benzoxadiazole) reactive group with a halogen (-F, -Cl) modification." [PMID:21557289]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:00159
name: hydrazine
def: "A hydrazine (R-NHNH2-) reactive group." [PMID:21557289]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:00160
name: TAD
def: "A 4-substituted 1,2,4-triazoline-3,5-dione (TAD) reactive group." [PMID:21557289]
synonym: "1,2,4-triazoline-3,5-dione" EXACT []
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:06514 ! Vitamin D metabolite reactive

[Term]
id: XLMOD:00161
name: boronic acid
def: "An (alkyl- or aryl-substituted) boronic acid (R-B-(OH)2) reactive group." [PMID:21557289]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06506 ! carbohydrate reactive

[Term]
id: XLMOD:00162
name: isothiocyanate
def: "An isothiocyanate (-N=C=S) reactive group." [PMID:21557289]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06500 ! secondary amine reactive

[Term]
id: XLMOD:00163
name: chloroformate reactive group
def: "A chloroformate (Cl-CO-OR) reactive group." [PMID:21557289]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06500 ! secondary amine reactive

[Term]
id: XLMOD:00164
name: carabamate
def: "A carbamate (O-CO-N) reactive group." [PMID:21557289]
synonym: "urethane" EXACT []
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06500 ! secondary amine reactive

[Term]
id: XLMOD:00165
name: sulfonate
def: "A sulfonate (R1-SO2O-R2) reactive group." [PMID:21557289]
synonym: "sulphonate" EXACT []
synonym: "sulfonic ester" EXACT []
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:00166
name: anhydride
def: "An anhydride (R1-CO-O-CO-R2) reactive group." [PMID:21557289]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive

[Term]
id: XLMOD:00167
name: carboxyl reactive group
def: "Reactive group (-COOH) that reacts with amino (-NH2) groups." [PSI:XL]
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00028 ! amine reactive

[Term]
id: XLMOD:00168
name: benzyl bromide reactive group
def: "A benzyl bromide (C6H5CH2Br) reactive group." [PMID:21557289]
synonym: "Bn-Br" EXACT []
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive
relationship: is_reactive_with XLMOD:06521 ! phosphate reactive

[Term]
id: XLMOD:00169
name: sodium dithionite cleavable
def: "Indicates that a cross-linker is chemically cleavable by sodium dithionite." [PSI:XL]
is_a: XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:00170
name: benzoyl bromide
def: "A benzoyl bromide (C6H5COBr) reactive group." [PMID:21557289]
synonym: "Bz-Br" EXACT []
is_a: XLMOD:00100 ! reactive group
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive
relationship: is_reactive_with XLMOD:06521 ! phosphate reactive

[Term]
id: XLMOD:00171
name: Ortho-phthalaldehyde
def: "A lysine-specific reactive group." [PSI:XL]
synonym: "OPA" EXACT []
property_value: specificities: "(K)" xsd:string
is_a: XLMOD:00116 ! aldehyde

[Term]
id: XLMOD:00172
name: IMAC-enrichable
def: "Indicates a cross-linker facilitating IMAC (immobilized metal affinity chromatography) enrichment." [PSI:XL]
is_a: XLMOD:00019 ! enrichable

[Term]
id: XLMOD:00173
name: phosphonic acid
def: "A phosphonic acid handle, which can be used for IMAC-enrichment." [PSI:XL]
is_a: XLMOD:00050 ! handle
is_a: XLMOD:00172 ! IMAC-enrichable

[Term]
id: XLMOD:01000
name: hydrolyzed BS3
def: "Hydrolyzed bis(sulfosuccinimidyl)suberate." [PSI:XL]
property_value: deadEndFormula: "C8 H12 O3" xsd:string
property_value: monoIsotopicMass: "156.07864431" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02000 ! BS3

[Term]
id: XLMOD:01001
name: ammonium amidated BS3
def: "Ammonium amidated bis(sulfosuccinimidyl)suberate." [PSI:XL]
property_value: deadEndFormula: "C8 H13 O2 N" xsd:string
property_value: monoIsotopicMass: "155.094628715" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02000 ! BS3

[Term]
id: XLMOD:01002
name: hydrolyzed DSS
def: "Hydrolyzed disuccinimidyl suberate." [PSI:XL]
property_value: deadEndFormula: "C8 H12 O3" xsd:string
property_value: monoIsotopicMass: "156.07864431" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02001 ! DSS

[Term]
id: XLMOD:01003
name: ammonium amidated DSS
def: "Ammonium amidated disuccinimidyl suberate." [PSI:XL]
property_value: deadEndFormula: "C8 H13 O2 N" xsd:string
property_value: monoIsotopicMass: "155.094628715" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02001 ! DSS

[Term]
id: XLMOD:01004
name: hydrolyzed DSS-d4
def: "Deuterium labelled hydrolyzed disuccinimidyl 2,2,7,7-suberate." [PSI:XL]
property_value: monoIsotopicMass: "160.1037416836" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02002 ! DSS-d4

[Term]
id: XLMOD:01005
name: ammonium amidated DSS-d4
def: "Deuterium labelled ammonium amidated disuccinimidyl 2,2,7,7-suberate." [PSI:XL]
property_value: monoIsotopicMass: "159.1197260886" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02002 ! DSS-d4

[Term]
id: XLMOD:01006
name: hydrolyzed DSS-d12
def: "Deuterium labelled hydrolyzed disuccinimidyl 2,2,3,3,4,4,5,5,6,6,7,7-suberate." [PSI:XL]
property_value: monoIsotopicMass: "168.153965238" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02003 ! DSS-d12

[Term]
id: XLMOD:01007
name: ammonium amidated DSS-d12
def: "Deuterium labelled ammonium amidated disuccinimidyl 2,2,3,3,4,4,5,5,6,6,7,7-suberate." [PSI:XL]
property_value: monoIsotopicMass: "167.169949643" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02003 ! DSS-d12

[Term]
id: XLMOD:01008
name: hydrolyzed BS3-d4
def: "Deuterium labelled hydrolyzed bis(sulfosuccinimidyl) 2,2,7,7-suberate." [PSI:XL]
property_value: deadEndFormula: "C8 D4 H8 O3" xsd:string
property_value: monoIsotopicMass: "160.103751286" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02004 ! BS3-d4

[Term]
id: XLMOD:01009
name: ammonium amidated BS3-d4
def: "Deuterium labelled ammonium amidated bis(sulfosuccinimidyl) 2,2,7,7-suberate." [PSI:XL]
property_value: deadEndFormula: "C8 D4 H9 N1 O2" xsd:string
property_value: monoIsotopicMass: "159.119735691" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02004 ! BS3-d4

[Term]
id: XLMOD:01010
name: hydrolyzed BS2G
def: "Hydrolyzed bis(sulfosuccinimidyl) glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 H6 O3" xsd:string
property_value: monoIsotopicMass: "114.0316941" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02005 ! BS2G

[Term]
id: XLMOD:01011
name: ammonium amidated BS2G
def: "Ammonium amidated bis(sulfosuccinimidyl) glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 H7 N1 O2" xsd:string
property_value: monoIsotopicMass: "113.047678505" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02005 ! BS2G

[Term]
id: XLMOD:01012
name: hydrolyzed DSG
def: "Hydrolyzed disuccinimidyl glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 H6 O3" xsd:string
property_value: monoIsotopicMass: "114.0316941" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02006 ! DSG

[Term]
id: XLMOD:01013
name: ammonium amidated DSG
def: "Ammonium amidated disuccinimidyl glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 H7 N1 O2" xsd:string
property_value: monoIsotopicMass: "113.047678505" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02006 ! DSG

[Term]
id: XLMOD:01014
name: hydrolyzed DSG-d4
def: "Deuterium labelled hydrolyzed disuccinimidyl 2,2,4,4-glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 D4 H2 O3" xsd:string
property_value: monoIsotopicMass: "118.0567741" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02007 ! DSG-d4

[Term]
id: XLMOD:01015
name: ammonium amidated DSG-d4
def: "Deuterium labelled ammonium amidated disuccinimidyl 2,2,4,4-glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 D4 H3 N1 O2" xsd:string
property_value: monoIsotopicMass: "117.072758505" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02007 ! DSG-d4

[Term]
id: XLMOD:01016
name: hydrolyzed BS2G-d4
def: "Deuterium labelled hydrolyzed bis(sulfosuccinimidyl) 2,2,4,4-glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 D4 H2 O3" xsd:string
property_value: monoIsotopicMass: "118.056801076" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02008 ! BS2G-d4

[Term]
id: XLMOD:01017
name: ammonium amidated BS2G-d4
def: "Deuterium labelled ammonium amidated bis(sulfosuccinimidyl) 2,2,4,4-glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 D4 H3 N1 O2" xsd:string
property_value: monoIsotopicMass: "117.072785481" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02008 ! BS2G-d4

[Term]
id: XLMOD:01018
name: BDP-NHP-stump
def: "Biotin Aspartate Proline n-hydroxyphthalimide-stump." [PMID:23413883, PMID:26235782, PMID:27089058]
property_value: monoIsotopicMass: "197.032422395" xsd:double
is_a: XLMOD:00002 ! cross-linker related chemical modification
relationship: is_side_product_of XLMOD:02011 ! BDP-NHP

[Term]
id: XLMOD:01019
name: hydrolyzed DSP
def: "Hydrolyzed dithiobis[succinimidyl propionate." [PSI:XL]
property_value: deadEndFormula: "C6 H8 O3 S2" xsd:string
property_value: monoIsotopicMass: "191.99148557" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02029 ! DSP

[Term]
id: XLMOD:01020
name: ammonium amidated DSP
def: "Ammonium amidated dithiobis[succinimidyl propionate." [PSI:XL]
property_value: deadEndFormula: "C6 H9 N1 O2 S2" xsd:string
property_value: monoIsotopicMass: "191.007469975" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02029 ! DSP

[Term]
id: XLMOD:01021
name: hydrolyzed EGS
def: "Hydrolyzed ethylene glycolbis(succinimidylsuccinate)." [PSI:XL]
property_value: deadEndFormula: "C10 H12 O7" xsd:string
property_value: monoIsotopicMass: "244.0583027" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02034 ! EGS

[Term]
id: XLMOD:01022
name: ammonium amidated EGS
def: "Ammonium amidated ethylene glycolbis(succinimidylsuccinate)." [PSI:XL]
property_value: deadEndFormula: "C10 H13 N1 O6" xsd:string
property_value: monoIsotopicMass: "243.074287105" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02034 ! EGS

[Term]
id: XLMOD:01023
name: hydrolyzed BiPS
def: "Hydrolyzed bimane bisthiopropionic acid N-succinimidyl ester." [PMID:18838738]
property_value: deadEndFormula: "C16 H18 N2 O5 S2" xsd:string
property_value: monoIsotopicMass: "382.06571" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02040 ! BiPS

[Term]
id: XLMOD:01024
name: ammonium amidated BiPS
def: "Ammonium amidated bimane bisthiopropionic acid N-succinimidyl ester." [PMID:18838738]
property_value: deadEndFormula: "C16 H18 N3 O4 S2" xsd:string
property_value: monoIsotopicMass: "381.08169" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02040 ! BiPS

[Term]
id: XLMOD:01025
name: hydrolyzed CBDPS
def: "Hydrolyzed cyanurbiotindipropionylsuccinimide." [PMID:20622150]
property_value: deadEndFormula: "C19 H25 N7 O5 S3" xsd:string
property_value: monoIsotopicMass: "527.10738" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02041 ! CBDPS

[Term]
id: XLMOD:01026
name: ammonium amidated CBDPS
def: "Ammonium amidated cyanurbiotindipropionylsuccinimide." [PMID:20622150]
property_value: deadEndFormula: "C19 H25 N8 O4 S3" xsd:string
property_value: monoIsotopicMass: "526.12336" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02041 ! CBDPS

[Term]
id: XLMOD:01027
name: hydrolyzed DSA
def: "Hydrolyzed disuccinimidyladipic acid." [PSI:XL]
property_value: deadEndFormula: "C6 H8 O3" xsd:string
property_value: monoIsotopicMass: "128.04680" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02044 ! DSA

[Term]
id: XLMOD:01028
name: ammonium amidated DSA
def: "Ammonium amidated disuccinimidyladipic acid." [PSI:XL]
property_value: deadEndFormula: "C6 H9 N1 O2" xsd:string
property_value: monoIsotopicMass: "127.06278" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02044 ! DSA

[Term]
id: XLMOD:01029
name: hydrolyzed DNBDPS
def: "Hydrolyzed DNBDPS." [PMID:20109223]
property_value: deadEndFormula: "C12 H10 N2 O7 S2" xsd:string
property_value: monoIsotopicMass: "357.99294" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: has_handle XLMOD:00054 ! DNB
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02045 ! DNBDPS

[Term]
id: XLMOD:01030
name: ammonium amidated DNBDPS
def: "Ammonium amidated DNBDPS." [PMID:20109223]
property_value: deadEndFormula: "C12 H10 N3 O6 S2" xsd:string
property_value: monoIsotopicMass: "357.00892" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: has_handle XLMOD:00054 ! DNB
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02045 ! DNBDPS

[Term]
id: XLMOD:01031
name: hydrolyzed TEABS
def: "Hydrolyzed TEABS cross-linking reagent." [PMID:20109223]
property_value: deadEndFormula: "C28 H41 N5 O12 S1" xsd:string
property_value: monoIsotopicMass: "671.24724" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02046 ! TEABS

[Term]
id: XLMOD:01032
name: ammonium amidated TEABS
def: "Ammonium amidated TEABS cross-linking reagent." [PMID:20109223]
property_value: deadEndFormula: "C28 H41 N6 O11 S1" xsd:string
property_value: monoIsotopicMass: "670.26322" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02046 ! TEABS

[Term]
id: XLMOD:01033
name: hydrolyzed DTSSP-d8
def: "Hydrolyzed deuterium labelled 3,3'-Dithiobis[sulfosuccinimidylpropionate]." [PMID:10975572, PMID:18510349]
property_value: deadEndFormula: "C6 D8 O3 S2" xsd:string
property_value: monoIsotopicMass: "191.99149" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02049 ! DTSSP

[Term]
id: XLMOD:01034
name: ammonium amidated DTSSP-d8
def: "Ammonium amidated deuterium labelled 3,3'-Dithiobis[sulfosuccinimidylpropionate]." [PMID:10975572, PMID:18510349]
property_value: deadEndFormula: "C6 D8 H1 N1 O2 S2" xsd:string
property_value: monoIsotopicMass: "191.00747" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02049 ! DTSSP

[Term]
id: XLMOD:01035
name: hydrolyzed DSP-d8
def: "Hydrolyzed deuterium-labelled dithiobis[succinimidyl propionate." [PSI:XL]
property_value: deadEndFormula: "C6 D8 O3 S2" xsd:string
property_value: monoIsotopicMass: "200.04165" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02030 ! DSP-d8

[Term]
id: XLMOD:01036
name: ammonium amidated DSP-d8
def: "Ammonium amidated deuterium-labelled dithiobis[succinimidyl propionate." [PSI:XL]
property_value: deadEndFormula: "C6 D8 H1 N1 O2 S2" xsd:string
property_value: monoIsotopicMass: "199.05763" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02030 ! DSP-d8

[Term]
id: XLMOD:01037
name: hydrolyzed Sulfo-EGS
def: "Hydrolyzed ethylene glycolbis(sulfosuccinimidylsuccinate)." [PSI:XL]
property_value: deadEndFormula: "C10 H12 O7" xsd:string
property_value: monoIsotopicMass: "244.0583028" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02035 ! Sulfo-EGS

[Term]
id: XLMOD:01038
name: ammonium amidated Sulfo-EGS
def: "Ammonium amidated ethylene glycolbis(sulfosuccinimidylsuccinate)." [PSI:XL]
property_value: deadEndFormula: "C10 H12 N1 O6" xsd:string
property_value: monoIsotopicMass: "243.07428" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02035 ! Sulfo-EGS

[Term]
id: XLMOD:01039
name: hydrolyzed EGS-d12
def: "Deuterium labelled hydrolyzed ethylene glycolbis(succinimidylsuccinate)." [PSI:XL]
property_value: deadEndFormula: "C10 D12 O7" xsd:string
property_value: monoIsotopicMass: "256.13403" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02050 ! EGS-d12

[Term]
id: XLMOD:01040
name: ammonium amidated EGS-d12
def: "Deuterium labelled ammonium amidated ethylene glycolbis(succinimidylsuccinate)." [PSI:XL]
property_value: deadEndFormula: "C10 D12 N1 O6" xsd:string
property_value: monoIsotopicMass: "255.15001" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02050 ! EGS-d12

[Term]
id: XLMOD:01041
name: hydrolyzed Sulfo-EGS-d12
def: "Deuterium labelled hydrolyzed ethylene glycolbis(sulfosuccinimidylsuccinate)." [PSI:XL]
property_value: deadEndFormula: "C10 D12 O7" xsd:string
property_value: monoIsotopicMass: "256.13403" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02050 ! Sulfo-EGS-d12

[Term]
id: XLMOD:01042
name: ammonium amidated Sulfo-EGS-d12
def: "Deuterium labelled ammonium amidated ethylene glycolbis(sulfosuccinimidylsuccinate)." [PSI:XL]
property_value: deadEndFormula: "C10 D12 N1 O6" xsd:string
property_value: monoIsotopicMass: "255.15001" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02050 ! Sulfo-EGS-d12

[Term]
id: XLMOD:01043
name: hydrolyzed DSA-13C6
def: "Hydrolyzed 13C labelled disuccinimidyladipic acid." [PSI:XL]
property_value: deadEndFormula: "13C6 H8 O3" xsd:string
property_value: monoIsotopicMass: "134.06696" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00036 ! 13C labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02054 ! DSA-13C6

[Term]
id: XLMOD:01044
name: ammonium amidated DSA-13C6
def: "Ammonium amidated 13C labelled disuccinimidyladipic acid." [PSI:XL]
property_value: deadEndFormula: "13C6 H9 N1 O2" xsd:string
property_value: monoIsotopicMass: "133.08294" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00036 ! 13C labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02054 ! DSA-13C6

[Term]
id: XLMOD:01045
name: hydrolyzed CBDPS-d8
def: "Deuterium labelled hydrolyzed cyanurbiotindipropionylsuccinimide." [PMID:20622150]
property_value: deadEndFormula: "C19 D8 H17 N7 O5 S3" xsd:string
property_value: monoIsotopicMass: "535.15754" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02055 ! CBDPS-d8

[Term]
id: XLMOD:01046
name: ammonium amidated CBDPS-d8
def: "Deuterium labelled ammonium amidated cyanurbiotindipropionylsuccinimide." [PMID:20622150]
property_value: deadEndFormula: "C19 D8 H17 N8 O4 S3" xsd:string
property_value: monoIsotopicMass: "534.17352" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02055 ! CBDPS-d8

[Term]
id: XLMOD:01047
name: hydrolyzed CBDPSS
def: "Hydrolyzed cyanurbiotindimercaptopropionylsulfosuccinimide." [PMID:20622150]
property_value: deadEndFormula: "C19 H25 N7 O5 S3" xsd:string
property_value: monoIsotopicMass: "527.10738" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02056 ! CBDPSS

[Term]
id: XLMOD:01048
name: ammonium amidated CBDPSS
def: "Ammonium amidated cyanurbiotindimercaptopropionylsulfosuccinimide." [PMID:20622150]
property_value: deadEndFormula: "C19 H25 N8 O4 S3" xsd:string
property_value: monoIsotopicMass: "526.12336" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02056 ! CBDPSS

[Term]
id: XLMOD:01049
name: hydrolyzed CBDPSS-d8
def: "Deuterium labelled hydrolyzed cyanurbiotindimercaptopropionylsulfosuccinimide." [PMID:20622150]
property_value: deadEndFormula: "C19 D8 H17 N7 O5 S3" xsd:string
property_value: monoIsotopicMass: "535.15754" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02057 ! CBDPSS-d8

[Term]
id: XLMOD:01050
name: ammonium amidated CBDPSS-d8
def: "Deuterium labelled ammonium amidated cyanurbiotindimercaptopropionylsulfosuccinimide." [PMID:20622150]
property_value: deadEndFormula: "C19 D8 H17 N8 O4 S3" xsd:string
property_value: monoIsotopicMass: "534.17352" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02057 ! CBDPSS-d8

[Term]
id: XLMOD:01051
name: hydrolyzed BS3-d12
def: "Deuterium labelled hydrolyzed bis(sulfosuccinimidyl) 2,2,3,3,4,4,5,5,6,6,7,7-suberate." [PSI:XL]
property_value: deadEndFormula: "C8 D12 O3" xsd:string
property_value: monoIsotopicMass: "168.15437" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02064 ! BS3-d12

[Term]
id: XLMOD:01052
name: ammonium amidated BS3-d12
def: "Deuterium labelled ammonium amidated bis(sulfosuccinimidyl) 2,2,3,3,4,4,5,5,6,6,7,7-suberate." [PSI:XL]
property_value: deadEndFormula: "C8 D12 H1 N1 O2" xsd:string
property_value: monoIsotopicMass: "167.17035" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02064 ! BS3-d12

[Term]
id: XLMOD:01053
name: hydrolyzed DSG-d6
def: "Deuterium labelled hydrolyzed disuccinimidyl 2,2,3,3,4,4-glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 D6 O3" xsd:string
property_value: monoIsotopicMass: "120.07483" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02065 ! DSG-d6

[Term]
id: XLMOD:01054
name: ammonium amidated DSG-d6
def: "Deuterium labelled ammonium amidated disuccinimidyl 2,2,3,3,4,4-glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 D6 H1 N1 O2" xsd:string
property_value: monoIsotopicMass: "119.09081" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02065 ! DSG-d6

[Term]
id: XLMOD:01055
name: hydrolyzed BS2G-d6
def: "Deuterium labelled hydrolyzed bis(sulfosuccinimidyl) 2,2,3,3,4,4-glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 D6 O3" xsd:string
property_value: monoIsotopicMass: "120.06877" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02066 ! BS2G-d6

[Term]
id: XLMOD:01056
name: ammonium amidated BS2G-d6
def: "Deuterium labelled ammonium amidated bis(sulfosuccinimidyl) 2,2,3,3,4,4-glutarate." [PSI:XL]
property_value: deadEndFormula: "C5 D6 H1 N1 O2" xsd:string
property_value: monoIsotopicMass: "119.08475" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02066 ! BS2G-d6

[Term]
id: XLMOD:01057
name: hydrolyzed SDH
def: "Hydrolyzed Suberic acid 1,8-dihydrazide." [PMID:24938783]
property_value: deadEndFormula: "C8 H16 N4 O1" xsd:string
property_value: monoIsotopicMass: "184.13241119" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02058 ! SDH

[Term]
id: XLMOD:01058
name: hydrolyzed SDH-d12
def: "Deuterium labelled hydrolyzed suberic acid 1,8-dihydrazide." [PMID:24938783]
property_value: deadEndFormula: "C8 D12 H4 N4 O1" xsd:string
property_value: monoIsotopicMass: "196.207732118" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02059 ! SDH-d12

[Term]
id: XLMOD:01059
name: hydrolyzed ADH
def: "Hydrolyzed adipic acid 1,6-dihydrazide." [PMID:24938783]
property_value: deadEndFormula: "C6 H12 N4 O1" xsd:string
property_value: monoIsotopicMass: "156.10111105" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02060 ! ADH

[Term]
id: XLMOD:01060
name: hydrolyzed ADH-d8
def: "Deuterium labelled hydrolyzed adipic acid 1,6-dihydrazide." [PMID:24938783]
property_value: deadEndFormula: "C6 D8 H4 N4 O1" xsd:string
property_value: monoIsotopicMass: "164.151325002" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02060 ! ADH-d8

[Term]
id: XLMOD:01061
name: hydrolyzed GDH
def: "Hydrolyzed glutaric acid 1,5-dihydrazide." [PMID:24938783]
property_value: deadEndFormula: "C5 H10 N4 O1" xsd:string
property_value: monoIsotopicMass: "142.08546098" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02062 ! GDH

[Term]
id: XLMOD:01062
name: hydrolyzed GDH-d6
def: "Deuterium labelled hydrolyzed glutaric acid 1,5-dihydrazide." [PMID:24938783]
property_value: deadEndFormula: "C5 D6 H4 N4 O1" xsd:string
property_value: monoIsotopicMass: "148.123121444" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02063 ! GDH-d6

[Term]
id: XLMOD:01063
name: hydrolyzed BCCL1
def: "Hydrolyzed bis-(N-hydroxysuccinimidyl) 3-amino-N-biotinoyl-1,5-pentanedioate." [PMID:19412923]
property_value: monoIsotopicMass: "355.12019" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02108 ! BCCL1

[Term]
id: XLMOD:01064
name: hydrolyzed BCCL2
def: "Hydrolyzed bis-(N-hydroxysuccinimidyl) 5-amino-N-biotinoyl-1,9-nonanedioate." [PMID:19412923]
property_value: monoIsotopicMass: "411.18179" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02109 ! BCCL2

[Term]
id: XLMOD:01065
name: hydrolyzed IRCX
def: "Hydrolyzed dibenzoyloxysuccinimidylethyl phosphate." [PMID:18517224]
property_value: monoIsotopicMass: "348.0" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02116 ! ICRX

[Term]
id: XLMOD:01066
name: hydrolyzed azide-DSG
def: "Hydrolyzed bis(succinimidyl)-3-azidomethyl glutarate." [PMID:20472459]
property_value: monoIsotopicMass: "229.0" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02118 ! azide-DSG

[Term]
id: XLMOD:01067
name: hydrolyzed JMV 3378
def: "Hydrolyzed crosslinking reagent JMV 3378." [PMID:19902427]
property_value: monoIsotopicMass: "286.0" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02120 ! JMV 3378

[Term]
id: XLMOD:01068
name: hydrolyzed BuTuGPG
def: "Hydrolyzed 4-[3-(2-{2-[(2,5-dioxo-pyrrolidin-1-yloxycarbonyl-methyl)-carbamoyl]-pyrrolidin-1-yl}-2-oxo-ethyl)-thioureido]-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester." [PMID:19950134]
property_value: monoIsotopicMass: "1704.86" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02121 ! BuTuGPG

[Term]
id: XLMOD:01069
name: hydrolyzed BuUrBu
def: "Hydrolyzed NHS-amino butyric acid-urea-amino butyric acid-NHS." [PMID:21157862]
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02122 ! BuUrBu

[Term]
id: XLMOD:01070
name: hydrolyzed DEST
def: "Hydrolyzed diethylsuberthioimidate." [PMID:20795639, PMID:22460622]
property_value: deadEndFormula: "C8 H14 N2 O1" xsd:string
property_value: monoIsotopicMass: "154.11061312" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02129 ! DEST

[Term]
id: XLMOD:01071
name: ammonium amidated DEST
def: "Ammonium amidated diethylsuberthioimidate." [PMID:20795639, PMID:22460622]
property_value: deadEndFormula: "C8 H15 N3" xsd:string
property_value: monoIsotopicMass: "153.126593" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02129 ! DEST

[Term]
id: XLMOD:01072
name: thioesterized DEST
def: "Thioesterized diethylsuberthioimidate." [PMID:20795639, PMID:22460622]
property_value: deadEndFormula: "C10 H17 N1 O1 S1" xsd:string
property_value: monoIsotopicMass: "199.103084925" xsd:double
is_a: XLMOD:00098 ! thioesterization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00047 ! thioesterized
relationship: is_side_product_of XLMOD:02129 ! DEST

[Term]
id: XLMOD:01073
name: hydrolyzed BS(PEG)5
def: "Hydrolyzed bis(sulfosuccinimidyl)suberate pentaethyleneglycol." [PSI:XL]
property_value: deadEndFormula: "C14 H24 O8" xsd:string
property_value: monoIsotopicMass: "320.1471147" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02198 ! BS(PEG)5

[Term]
id: XLMOD:01074
name: ammonium amidated BS(PEG)5
def: "Ammonium amidated bis(sulfosuccinimidyl)suberate pentaethyleneglycol." [PSI:XL]
property_value: deadEndFormula: "C14 H27 N1 O7" xsd:string
property_value: monoIsotopicMass: "320.1471147" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02198 ! BS(PEG)5

[Term]
id: XLMOD:01075
name: hydrolyzed BSOCOES
def: "Hydrolyzed bis(2-[Succinimidooxycarbonyloxy]ethyl) sulfone." [PSI:XL]
property_value: deadEndFormula: "C6 H8 O7 S1" xsd:string
property_value: monoIsotopicMass: "223.9990767" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02079 ! BSOCOES

[Term]
id: XLMOD:01076
name: ammonium amidated BSOCOES
def: "Ammonium amidated bis(2-[Succinimidooxycarbonyloxy]ethyl) sulfone." [PSI:XL]
property_value: deadEndFormula: "C6 H9 N1 O6 S1" xsd:string
property_value: monoIsotopicMass: "223.015061105" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02079 ! BSOCOES

[Term]
id: XLMOD:01077
name: hydrolyzed DST
def: "Hydrolyzed disuccinimidyl tartrate." [PSI:XL]
property_value: deadEndFormula: "C4 H4 O5" xsd:string
property_value: monoIsotopicMass: "132.0058747" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02032 ! DST

[Term]
id: XLMOD:01078
name: ammonium amidated DST
def: "Ammonium amidated disuccinimidyl tartrate." [PSI:XL]
property_value: deadEndFormula: "C4 H5 N1 O4" xsd:string
property_value: monoIsotopicMass: "131.021859105" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02032 ! DST

[Term]
id: XLMOD:01079
name: hydrolyzed SDA
def: "Hydrolyzed succinimidyl-ester diazirine." [PSI:XL]
property_value: deadEndFormula: "C5 H8 O2" xsd:string
property_value: monoIsotopicMass: "100.05242954" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02138 ! SDA

[Term]
id: XLMOD:01080
name: oxidized SDA
def: "Oxidized succinimidyl-ester diazirine." [PSI:XL]
property_value: deadEndFormula: "C5 H6 O2" xsd:string
property_value: monoIsotopicMass: "98.03677947" xsd:double
is_a: XLMOD:00097 ! oxidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00064 ! oxidized
relationship: is_side_product_of XLMOD:02138 ! SDA

[Term]
id: XLMOD:01081
name: alkenized SDA
def: "Alkenized succinimidyl-ester diazirine." [PSI:XL]
property_value: deadEndFormula: "C4 H4 O1" xsd:string
property_value: monoIsotopicMass: "68.02621477" xsd:double
is_a: XLMOD:00094 ! alkenization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00065 ! alkenized
relationship: is_side_product_of XLMOD:02138 ! SDA

[Term]
id: XLMOD:01082
name: hydrolyzed LC-SDA
def: "Hydrolyzed LC-SDA." [PSI:XL]
property_value: deadEndFormula: "C11 H19 N1 O3" xsd:string
property_value: monoIsotopicMass: "213.136493555" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02139 ! LC-SDA

[Term]
id: XLMOD:01083
name: oxidized LC-SDA
def: "Oxidized LC-SDA." [PSI:XL]
property_value: deadEndFormula: "C11 H17 N1 O3" xsd:string
property_value: monoIsotopicMass: "211.120843485" xsd:double
is_a: XLMOD:00097 ! oxidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00064 ! oxidized
relationship: is_side_product_of XLMOD:02139 ! LC-SDA

[Term]
id: XLMOD:01084
name: alkenized LC-SDA
def: "Alkenized LC-SDA." [PSI:XL]
property_value: deadEndFormula: "C10 H15 N1 O2" xsd:string
property_value: monoIsotopicMass: "181.110278785" xsd:double
is_a: XLMOD:00094 ! alkenization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00065 ! alkenized
relationship: is_side_product_of XLMOD:02139 ! LC-SDA

[Term]
id: XLMOD:01085
name: hydrolyzed L-Photo-Leucine
def: "Hydrolyzed L-2-amino-4,4-azi-pentanoic acid." [PSI:XL]
property_value: deadEndFormula: "-C1 -H2 O1" xsd:string
property_value: monoIsotopicMass: "1.97926456" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:01900 ! L-Photo-Leucine

[Term]
id: XLMOD:01086
name: oxidized L-Photo-Leucine
def: "Oxidized L-2-amino-4,4-azi-pentanoic acid." [PSI:XL]
property_value: deadEndFormula: "-C1 -H4 O1" xsd:string
property_value: monoIsotopicMass: "-0.036385501" xsd:double
is_a: XLMOD:00097 ! oxidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00064 ! oxidized
relationship: is_side_product_of XLMOD:01900 ! L-Photo-Leucine

[Term]
id: XLMOD:01087
name: alkenized L-Photo-Leucine
def: "Alkenized L-2-amino-4,4-azi-pentanoic acid." [PSI:XL]
property_value: deadEndFormula: "-C2 -H6" xsd:string
property_value: monoIsotopicMass: "-30.04695021" xsd:double
is_a: XLMOD:00094 ! alkenization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00065 ! alkenized
relationship: is_side_product_of XLMOD:01900 ! L-Photo-Leucine

[Term]
id: XLMOD:01088
name: hydrolyzed L-Photo-Methionine
def: "Hydrolyzed L-2-amino-5,5-azi-hexanoic acid." [PSI:XL]
property_value: deadEndFormula: "C1 H2 O1 -S1" xsd:string
property_value: monoIsotopicMass: "-1.96150744" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:01901 ! L-Photo-Methionine

[Term]
id: XLMOD:01089
name: oxidized L-Photo-Methionine
def: "Oxidized L-2-amino-5,5-azi-hexanoic acid." [PSI:XL]
property_value: deadEndFormula: "C1 O1 -S1" xsd:string
property_value: monoIsotopicMass: "-3.97715607" xsd:double
is_a: XLMOD:00097 ! oxidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00064 ! oxidized
relationship: is_side_product_of XLMOD:01901 ! L-Photo-Methionine

[Term]
id: XLMOD:01090
name: alkenized L-Photo-Methionine
def: "Alkenized L-2-amino-5,5-azi-hexanoic acid." [PSI:XL]
property_value: deadEndFormula: "-H2 -S1" xsd:string
property_value: monoIsotopicMass: "-33.98772221" xsd:double
is_a: XLMOD:00094 ! alkenization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00065 ! alkenized
relationship: is_side_product_of XLMOD:01901 ! L-Photo-Methionine

[Term]
id: XLMOD:01091
name: hydrolyzed BMOE
def: "Hydrolyzed bis-Maleimidoethane." [PSI:XL]
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02188 ! BMOE

[Term]
id: XLMOD:01092
name: hydrolyzed BMPS
def: "Hydrolyzed N-(beta-Maleimidopropyloxy)succinimide ester." [PSI:XL]
property_value: bridgeFormula: "C7 H7 O4 N1" xsd:string
property_value: monoIsotopicMass: "169.037507765" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02013 ! BMPS

[Term]
id: XLMOD:01093
name: ammonium amidated BMPS
def: "Ammonium amidated N-(beta-Maleimidopropyloxy)succinimide ester." [PSI:XL]
property_value: bridgeFormula: "C7 H8 O3 N2" xsd:string
property_value: monoIsotopicMass: "168.05349217" xsd:double
is_a: XLMOD:00095 ! ammonium amidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00021 ! ammonium amidated
relationship: is_side_product_of XLMOD:02013 ! BMPS

[Term]
id: XLMOD:01094
name: hydrolyzed PDH
def: "Hydrolyzed pimelic acid dihydrazide." [PSI:XL]
property_value: bridgeFormula: "C7 H12 N4" xsd:string
property_value: monoIsotopicMass: "170.11676112" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02223 ! PDH

[Term]
id: XLMOD:01095
name: hydrolyzed PDH-d10
def: "Deuterium labelled hydrolyzed pimelic acid dihydrazide." [PSI:XL]
property_value: bridgeFormula: "C7 D10 H2 N4" xsd:string
property_value: doubletDeltaMass: "10.06276744" xsd:double
property_value: monoIsotopicMass: "180.17952856" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02224 ! PDH-d10
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:01096
name: hydrolyzed SuDP
def: "Hydrolyzed disuccinimidyl-succinamyl-aspartyl-proline." [PMID:26091612]
property_value: monoIsotopicMass: "294.0852" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02112 ! SuDP

[Term]
id: XLMOD:01097
name: hydrolyzed L-Photo-Isoleucine
def: "Hydrolyzed L-Photo-Isoleucine." [PSI:XL]
property_value: deadEndFormula: "-C1 -H2 O1" xsd:string
property_value: monoIsotopicMass: "1.97926456" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:01902 ! L-Photo-Isoleucine

[Term]
id: XLMOD:01098
name: oxidized L-Photo-Isoleucine
def: "Oxidized L-Photo-Isoleucine." [PSI:XL]
property_value: deadEndFormula: "-C1 -H4 O1" xsd:string
property_value: monoIsotopicMass: "-0.036385501" xsd:double
is_a: XLMOD:00097 ! oxidation cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00064 ! oxidized
relationship: is_side_product_of XLMOD:01902 ! L-Photo-Isoleucine

[Term]
id: XLMOD:01099
name: alkenized L-Photo-Isoleucine
def: "Alkenized L-Photo-Isoleucine." [PSI:XL]
property_value: deadEndFormula: "-C2 -H6" xsd:string
property_value: monoIsotopicMass: "-30.04695021" xsd:double
is_a: XLMOD:00094 ! alkenization cross-linker related chemical modification
relationship: is_partially_reacted XLMOD:00065 ! alkenized
relationship: is_side_product_of XLMOD:01902 ! L-Photo-Isoleucine

[Term]
id: XLMOD:01100
name: hydrolyzed Sulfo-SBED
def: "Hydrolyzed Sulfo-SBED cross-linker." [PMID:16246579]
property_value: monoIsotopicMass: "652.217" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:03002 ! Sulfo-SBED

[Term]
id: XLMOD:01101
name: hydrolyzed PIR
def: "Hydrolized Protein Interaction Reporter." [PMID:15623310]
property_value: CID_Fragment: "828.5" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_cleavable XLMOD:00035 ! CID cleavable
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02237 ! PIR

[Term]
id: XLMOD:01102
name: hydrolized PL
def: "Hydrolyzed photo-cleavable Leiker." [PMID:26952210, PMID:27734140]
property_value: monoIsotopicMass: "334.15" xsd:double
is_a: XLMOD:00096 ! hydrolization cross-linker related chemical modification
relationship: is_cleavable XLMOD:00147 ! photocleavable
relationship: is_partially_reacted XLMOD:00011 ! hydrolyzed
relationship: is_side_product_of XLMOD:02227 ! PL

[Term]
id: XLMOD:01700
name: 8-methoxypsoralen
def: "8-methoxypsoralen reagent." [CAS:298-81-7, PubChem_Compound:4114, ChemSpiderID:3971, ChemicalBookNo:CB6733540, PMID:9013628]
synonym: "8-MOP" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00100 ! reactive group
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:01701
name: 4'-hydroxymethyl-4,5'8-trimethylpsoralen
def: "4'-hydroxymethyl-4,5'8-trimethylpsoralen reagent." [CAS:62442-59-5, PubChem_Compound:104953, ChemSpiderID:94710, MDL:MFCD00036888, ChemicalBookNo:CB7358269, PMID:9013628]
synonym: "HMT" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00100 ! reactive group
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:01702
name: 5-iodouracil
def: "5-iodouracil reagent." [CAS:696-07-1, PubChem_Compound:69672, MDL:MFCD00006020, ChemSpiderID:62873, ChemicalBookNo:CB8771577, PMID:12476441, PMID:9013628]
synonym: "5-IU" EXACT []
synonym: "5IU" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00081 ! nucleobase derivative
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00080 ! uracil

[Term]
id: XLMOD:01703
name: 4-thiouracil
def: "4-thiouracil reagent." [CAS:591-28-6, PubChem_Compound:2734394, MDL:MFCD00090842, ChemSpiderID:2016146, ChemicalBookNo:CB4469328, PMID:12476441, PMID:22575267]
synonym: "4-SU" EXACT []
synonym: "4SU" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00081 ! nucleobase derivative
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00080 ! uracil

[Term]
id: XLMOD:01704
name: 6-thioguanosine
def: "6-thioguanosine reagent." [CAS:85-31-4, PubChem_Compound:2724387, ChemSpiderID:2006534, ChemicalBookNo:CB3722231, PMID:20946768, PMID:22575267]
synonym: "6-SG" EXACT []
synonym: "6SG" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00088 ! nucleoside derivative
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00084 ! guanosine

[Term]
id: XLMOD:01705
name: 5-bromouracil
def: "5-bromouracil reagent." [CAS:51-20-7, PubChem_Compound:5802, ChemSpiderID:5597, Beilstein:127176, MDL:MFCD00006017, ChemicalBookNo:CB6388195, PMID:9145285, PMID:22575267]
synonym: "5-BU" EXACT []
synonym: "5BU" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00081 ! nucleobase derivative
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00080 ! uracil

[Term]
id: XLMOD:01706
name: 5-iodocytosine
def: "5-iodocytosine reagent." [CAS:1122-44-7, PubChem_Compound:14281, MDL:MFCD00023162, ChemSpiderID:13643, ChemicalBookNo:CB9203633, PMID:9145285]
synonym: "5-IC" EXACT []
synonym: "5IC" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00088 ! nucleoside derivative
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00078 ! cytosine

[Term]
id: XLMOD:01707
name: 8-azidoadenosine
def: "8-azidoadenosine reagent." [CAS:4372-67-2, ChemSpiderID:141244, ChemicalBookNo:CB7166563, PMID:9145285]
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00088 ! nucleoside derivative
relationship: has_reactive_group XLMOD:00055 ! azide
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00083 ! adenosine

[Term]
id: XLMOD:01708
name: 2-azidoadenosine
def: "2-azidoadenosine reagent." [CAS:59587-07-4, PubChem_Compound:510978, ChemicalBookNo:CB01175626, PMID:9145285]
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00088 ! nucleoside derivative
relationship: has_reactive_group XLMOD:00055 ! azide
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00083 ! adenosine

[Term]
id: XLMOD:01709
name: 8-azidoguanosine
def: "8-azidoguanosine reagent." [PubChem_Compound:23375450, ChemSpiderID:8034117, PMID:9145285]
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00088 ! nucleoside derivative
relationship: has_reactive_group XLMOD:00055 ! azide
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00084 ! guanosine

[Term]
id: XLMOD:01710
name: 5-azidouridine
def: "5-azidouridine reagent." [CAS:1261272-24-5, PubChem_Compound:20832934, ChemSpiderID:18697526, ChemicalBookNo:CB62543444, PMID:9145285]
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00088 ! nucleoside derivative
relationship: has_reactive_group XLMOD:00055 ! azide
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00086 ! uridine

[Term]
id: XLMOD:01711
name: bis-[3-(2-ketobutyraldehyde)ether
def: "bis-[3-(2-ketobutyraldehyde)ether reagent." [CAS:84031-85-6, PubChem_Compound:134685, ChemSpiderID:118706, ChemicalBookNo:CB81338982, PMID:16875836]
synonym: "Bikethoxal" EXACT []
synonym: "BKT" EXACT []
property_value: monoIsotopicMass: "230.079" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "5.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00115 ! glyoxal

[Term]
id: XLMOD:01712
name: mechlorethamine
def: "Mechlorethamine reagent." [CAS:55-86-7, PubChem_Compound:4033, MDL:MFCD00012517, ChemSpiderID:3893, ChemicalBookNo:CB5270716, PMID:16875836]
synonym: "Nitrogen mustard" EXACT []
synonym: "NM" EXACT []
property_value: monoIsotopicMass: "83.073" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.5" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00153 ! chloroethyl

[Term]
id: XLMOD:01713
name: 4-[bis-(2-chloroethyl)amino]benzenebutanoic acid
def: "4-[bis-(2-chloroethyl)amino]benzenebutanoic acid reagent." [CAS:305-03-3, PubChem_Compound:2708, Beilstein:999011, MDL:MFCD00021783, ChemSpiderID:2607, ChemicalBookNo:CB5270716, PMID:16875836]
synonym: "Chlorambucil" EXACT []
synonym: "CHB" EXACT []
property_value: monoIsotopicMass: "231.126" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.5" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00153 ! chloroethyl

[Term]
id: XLMOD:01714
name: sym-triazine trichloride
def: "Sym-triazine trichloride reagent." [CAS:108-80-5, PubChem_Compound:24851182, Beilstein:126982, MDL:MFCD00082990, ChemSpiderID:7668, ChemicalBookNo:CB5852763, PMID:16875836]
synonym: "Cyanuric acid" EXACT []
synonym: "STT" EXACT []
property_value: monoIsotopicMass: "110.962" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "2.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker

[Term]
id: XLMOD:01715
name: Heteroconjugate 20
def: "Heteroconjugate 20 reagent." [PMID:26335278]
synonym: "HC20" EXACT []
property_value: monoIsotopicMass: "1554.6871" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! bifunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin

[Term]
id: XLMOD:01716
name: benzophenone-4-iodoacetamide
def: "Benzophenone-4-iodoacetamide reagent." [CAS:76809-63-7, PubChem_Compound:131289, ChemicalBookNo:CB3488704, PMID:10208813]
synonym: "BPI" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00119 ! benzophenone
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:01717
name: azidophenacyl bromide
def: "Azidophenacyl bromide reagent." [CAS:57018-46-9, PubChem_Compound:92627, Beilstein:1961705, MDL:MFCD00042637, ChemSpiderID:83619, ChemicalBookNo:CB3120420, PMID:10208813]
synonym: "APB" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_fluorophore XLMOD:06110 ! phenacyl
relationship: has_reactive_group XLMOD:00126 ! phenyl azide
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:01718
name: benzophenone-phosphatidylcholine
def: "Benzophenone-phosphatidylcholine." [PMID:19171301]
synonym: "benzophenone-PC" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00092 ! lipid analogue
relationship: has_reactive_group XLMOD:00119 ! benzophenone
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:01719
name: phenylazide-phosphatidylcholine
def: "Phenylazide-phosphatidylcholine." [PMID:19171301]
synonym: "phenylazide-PC" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00092 ! lipid analogue
relationship: has_reactive_group XLMOD:00126 ! phenyl azide
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:01720
name: N-(4-azidosalicylamidyl)-1,2-dilauroyl-sn-glycero-3-phosphoethanolamine
def: "The N-(4-azidosalicylamidyl)-1,2-dilauroyl-sn-glycero-3-phosphoethanolamine lipid analogue used for lipid-protein cross-linking." [PMID:19171301]
synonym: "ASA" EXACT []
is_a: XLMOD:00092 ! lipid analogue

[Term]
id: XLMOD:01721
name: Ac5-5-SiaDAz
def: "The Ac5-5-SiaDAz sialic acid analogue used for glycan-protein cross-linking." [PMID:18293988, PMID:19536272]
is_a: XLMOD:00093 ! sialic acid analogue

[Term]
id: XLMOD:01722
name: Ac4-ManNDAz
def: "The Ac4-ManNDAz sialic acid analogue used for glycan-protein cross-linking." [PMID:18293988, PMID:19536272, PMID:20816498]
is_a: XLMOD:00093 ! sialic acid analogue

[Term]
id: XLMOD:01723
name: Ac4-ManNAc
def: "The Ac4-ManNAc sialic acid analogue used for glycan-protein cross-linking." [PMID:19536272]
is_a: XLMOD:00093 ! sialic acid analogue

[Term]
id: XLMOD:01724
name: Ac4-GlcNDAz
def: "The Ac4-GlcNDAz sialic acid analogue used for glycan-protein cross-linking." [PMID:19536272, PMID:20816498]
is_a: XLMOD:00093 ! sialic acid analogue

[Term]
id: XLMOD:01725
name: Ac5-methyl-SiaDAz
def: "The Ac5-methyl-SiaDAz sialic acid analogue used for glycan-protein cross-linking." [PMID:20816498]
is_a: XLMOD:00093 ! sialic acid analogue

[Term]
id: XLMOD:01726
name: sialylated LacNAc-biotin
def: "Sialylated LacNAc-biotin used for glycan-protein cross-linking." [PMID:26541974]
is_a: XLMOD:00093 ! sialic acid analogue

[Term]
id: XLMOD:01800
name: Psoralen-PEG3-Biotin
def: "Psoralen-PEG3-Biotin biotinylation reagent." [PSI:XL]
property_value: hydrophilicPEGchain: "3" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "36.86" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00134 ! psoralen

[Term]
id: XLMOD:01801
name: Photoactivatable Biotin
def: "Photoactivatable Biotin biotinylation reagent." [PSI:XL]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "30.0" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00107 ! nitrophenyl azide
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:01802
name: TFPA-PEG3-Biotin
def: "TFPA-PEG3-Biotin biotinylation reagent." [CAS:1264662-85-2, ChemSpiderID:59757057]
property_value: hydrophilicPEGchain: "3" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "33.4" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00118 ! tetrafluorophenyl azide

[Term]
id: XLMOD:01803
name: Biotin-LC-ASA
def: "1-(4-azidosalicylamido)-6(biotinamido)-hexane." [ChemicalBookNo:CB9438943]
synonym: "Biotin-Long Chain-ASA" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "29.9" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00020 ! iodinatable
relationship: has_reactive_group XLMOD:00125 ! hydroxyphenyl azide

[Term]
id: XLMOD:01804
name: Sulfo-NHS-Biotin
def: "Biotin 3-sulfo-N-hydroxysuccinimide ester sodium salt." [CAS:119616-38-5, PubChem_Compound:56846292, ChemSpiderID:28568147, ChemicalBookNo:CB8277468]
synonym: "Sulfosuccinimidyl biotin" EXACT []
synonym: "N-Hydroxysulfosuccinimidobiotin" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "13.5" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester

[Term]
id: XLMOD:01805
name: Sulfo-NHS-LC-Biotin
def: "Sulfo-NHS-LC-Biotin biotinylation reagent." [CAS:127062-22-0, PubChem_Compound:71571497, ChemSpiderID:29788101, ChemicalBookNo:CB7387089]
synonym: "Long chain Sulfo-NHS-Biotin" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "22.4" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester

[Term]
id: XLMOD:01806
name: NHS-PEG12-Biotin
def: "NHS-PEG12-Biotin biotinylation reagent." [CAS:365441-71-0, PubChem_Compound:58481068, ChemSpiderID:29354431, ChemicalBookNo:CB52546796]
synonym: "Biotin-PEG12-NHS ester" EXACT []
property_value: hydrophilicPEGchain: "12" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "56" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:01807
name: NHS-SS-PEG4-Biotin
def: "NHS-SS-PEG4-Biotin biotinylation reagent." [PSI:XL]
property_value: hydrophilicPEGchain: "4" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "37.9" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:01808
name: NHS-Biotin
def: "Biotin N-hydroxysuccinimide ester." [CAS:35013-72-0, PubChem_Compound:434213, ChemSpiderID:5142865, ChemicalBookNo:CB7371998]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "13.5" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:01809
name: NHS-LC-Biotin
def: "Biotinamidohexanoyl-6-aminohexanoic acid N-hydroxysuccinimide ester." [CAS:89889-52-1, PubChem_Compound:4072290, ChemSpiderID:17346377, ChemicalBookNo:CB1412590]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "30.5" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:01810
name: NHS-SS-Biotin
def: "Biotin disulfide N-hydroxysuccinimide ester." [CAS:142439-92-7, PubChem_Compound:71312116, ChemSpiderID:3405732, ChemicalBookNo:CB4216304]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "24.3" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:01811
name: NHS-Iminobiotin trifluoroacetamide
def: "NHS-Iminobiotin trifluoroacetamide biotinylation reagent." [ChemicalBookNo:CB6315012]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "13.5" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00071 ! iminobiotintrifluoroacetamide
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:01812
name: PFP-Biotin
def: "Pentafluorophenyl-Biotin." [CAS:120550-35-8, PubChem_Compound:11122445, ChemSpiderID:9297574, ChemicalBookNo:CB6307189]
synonym: "Biotin-PFP-ester" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "9.6" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00120 ! pentafluorophenyl

[Term]
id: XLMOD:01813
name: TFP-PEG3-Biotin
def: "Tetrafluorophenyl-PEG3-Biotin." [PSI:XL]
property_value: hydrophilicPEGchain: "3" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "32.6" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00150 ! tetrafluorophenyl ester

[Term]
id: XLMOD:01814
name: Maleimide-PEG11-Biotin
def: "Maleimide-PEG11-Biotin biotinylation reagent." [PSI:XL]
property_value: hydrophilicPEGchain: "11" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "59.1" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:01815
name: Biotin-BMCC
def: "1-Biotinamido-4-[4´-(maleimidomethyl)cyclohexanecarboxamido]butane." [ChemicalBookNo:CB5366406]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "32.6" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:01816
name: Iodoacetyl-PEG2-Biotin
def: "Iodoacetyl-PEG2-Biotin biotinylation reagent." [PSI:XL]
property_value: hydrophilicPEGchain: "2" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "24.7" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00127 ! iodoacetyl

[Term]
id: XLMOD:01817
name: Iodoacetyl-LC-Biotin
def: "Iodoacetyl-LC-Biotin biotinylation reagent." [CAS:93285-75-7, PubChem_Compound:125043, ChemSpiderID:4248811, ChemicalBookNo:CB5664328]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "27.1" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00127 ! iodoacetyl

[Term]
id: XLMOD:01818
name: Pentylamine-Biotin
def: "5-(Biotinamido)pentylamine." [CAS:115416-38-1, PubChem_Compound:83906, ChemSpiderID:75715, ChemicalBookNo:CB8415868]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "18.9" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00151 ! pentylamine

[Term]
id: XLMOD:01819
name: Amine-PEG2-Biotin
def: "5-(Biotinamido)pentylamine." [PubChem_Compound:11199678]
synonym: "Biotin-PEG2-amine" EXACT []
property_value: hydrophilicPEGchain: "2" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "20.4" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00133 ! amine reactive group

[Term]
id: XLMOD:01820
name: Amine-PEG3-Biotin
def: "Amine-PEG3-Biotin biotinylation reagent." [PubChem_Compound:53384310]
synonym: "Biotin-PEG3-amine" EXACT []
property_value: hydrophilicPEGchain: "3" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "22.9" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00133 ! amine reactive group

[Term]
id: XLMOD:01821
name: Biocytine-Hydrazide
def: "Biocytine-Hydrazide biotinylation reagent." [CS:102743-85-1, PubChem_Compound:128197]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "19.7" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:01822
name: Biotin-Hydrazide
def: "Biocytine-Hydrazide biotinylation reagent." [CAS:66640-86-6, PubChem_Compound:83872, ChemSpiderID:75684, ChemicalBookNo:CB3175354]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "15.7" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:01823
name: Biotin-LC-Hydrazide
def: "Long chain Biocytine-Hydrazide biotinylation reagent." [CAS:109276-34-8, PubChem_Compound:3504484, ChemSpiderID:75709, ChemicalBookNo:CB4309220]
synonym: "Biotin-LC-Hz" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "24.7" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:01824
name: Biotin-PEG4-Hydrazide
def: "Biotin-PEG4-Hydrazide biotinylation reagent." [PubChem_Compound:51340934]
property_value: hydrophilicPEGchain: "4" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "31.3" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:01825
name: Photobiotin
def: "Photoactivatable Biotin." [CAS:96087-37-5, PubChem_Compound:15949227, ChemSpiderID:2299671, ChemicalBookNo:CB7301795]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "30.0" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00107 ! nitrophenyl azide 

[Term]
id: XLMOD:01826
name: Biotin-PEG2-Alkyne
def: "Biotin-PEG2-Alkyne." [PubChem_Compound:91757772]
property_value: hydrophilicPEGchain: "2" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_handle XLMOD:00053 ! alkyne
relationship: is_cleavable XLMOD:00034 ! photo cleavable

[Term]
id: XLMOD:01827
name: Biotin-PEG2-C4-Alkyne
def: "Biotin-PEG2-C4-Alkyne." [CAS:109276-34-8, PubChem_Compound:91757769, ChemSpiderID:75709, ChemicalBookNo:CB73062389]
property_value: hydrophilicPEGchain: "2" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_handle XLMOD:00053 ! alkyne
relationship: is_cleavable XLMOD:00034 ! photo cleavable

[Term]
id: XLMOD:01828
name: Biotin-PEG4-Alkyne
def: "Biotin-PEG4-Alkyne." [CAS:1458576-00-5, PubChem_Compound:75409985, ChemicalBookNo:CB82984377]
property_value: hydrophilicPEGchain: "4" xsd:nonNegativeInteger
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_handle XLMOD:00053 ! alkyne
relationship: is_cleavable XLMOD:00034 ! photo cleavable

[Term]
id: XLMOD:01829
name: 2-iminothiolane
def: "2-iminothiolane reagent." [CAS:4781-83-3, PubChem_Compound:433941, MDL:MFCD00039013, ChemSpiderID:10732937, ChemicalBookNo:CB7373482, PMID:6170935, PMID:11350598]
synonym: "Traut's reagent" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00154 ! imino
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:01830
name: 3-Azidopyridine-adenine dinucleotide
def: "3-Azidopyridine-adenine dinucleotide reagent." [CAS:50695-15-3, PubChem_Compound:189126, MDL:MFCD00078882, ChemSpiderID:164324, ChemicalBookNo:CB91349828, PMID:20946768, PMID:6770736]
synonym: "APA" EXACT []
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00114 ! aryl azide
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:01900
name: L-Photo-Leucine
def: "L-2-amino-4,4-azi-pentanoic acid." [CAS:851960-91-3, ChemSpiderID:32980228, PMID:15782218, PMID:26700045]
synonym: "L-Photo-Leu" EXACT []
comment: A photoreactive amino acid analog of L-Leucine for incorporation during protein synthesis that can be used for in vivo labelling, cross-linking and protein-protein interaction studies in live cells.
property_value: bridgeFormula: "-C1 -H4" xsd:string
property_value: monoIsotopicMass: "-16.0313" xsd:double
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00049 ! amino acid derivative
relationship: has_reactive_group XLMOD:00103 ! diazirine
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00059 ! L-Leucine

[Term]
id: XLMOD:01901
name: L-Photo-Methionine
def: "L-2-amino-5,5-azi-hexanoic acid." [CAS:851960-68-4, ChemSpiderID:61327213, PMID:15782218, PMID:26700045]
synonym: "L-Photo-Met" EXACT []
comment: A photoreactive amino acid analog of L-Methionine for incorporation during protein synthesis that can be used for in vivo labelling, cross-linking and protein-protein interaction studies in live cells.
property_value: bridgeFormula: "C1 -S1" xsd:string
property_value: monoIsotopicMass: "-19.972072" xsd:double
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00049 ! amino acid derivative
relationship: has_reactive_group XLMOD:00103 ! diazirine
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00060 ! L-Methionine

[Term]
id: XLMOD:01902
name: L-Photo-Isoleucine
def: "L-Photo-Isoleucine." [PMID:16477643]
synonym: "L-Photo-Ile" EXACT []
comment: A photoreactive amino acid analog of L-Isoleucine for incorporation during protein synthesis that can be used for in vivo labelling, cross-linking and protein-protein interaction studies in live cells.
property_value: bridgeFormula: "-C1 -H4" xsd:string
property_value: monoIsotopicMass: "-16.0313" xsd:double
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00049 ! amino acid derivative
relationship: has_reactive_group XLMOD:00103 ! diazirine
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00068 ! L-Isoleucine

[Term]
id: XLMOD:01903
name: pBpa
def: "p-benzoyl-L-phenylalanine." [PMID:16170867]
comment: A photoreactive amino acid analog of L-Phenylalanine for incorporation during protein synthesis that can be used for in vivo labelling, cross-linking and protein-protein interaction studies in live cells.
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00049 ! amino acid derivative
relationship: has_reactive_group XLMOD:00119 ! benzophenone
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00070 ! L-Phenylalanine

[Term]
id: XLMOD:01904
name: pBpa-d11
def: "Deuterium labelled p-benzoyl-L-phenylalanine." [PMID:18704231]
comment: A photoreactive deuterium-labelled amino acid analog of L-Phenylalanine for incorporation during protein synthesis that can be used for in vivo labelling, cross-linking and protein-protein interaction studies in live cells.
property_value: reactionSites: "1" xsd:nonNegativeInteger
is_a: XLMOD:00049 ! amino acid derivative
relationship: has_reactive_group XLMOD:00119 ! benzophenone
relationship: is_activatable XLMOD:00149 ! photoactivatable
relationship: is_analog_of XLMOD:00070 ! L-Phenylalanine
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02000
name: BS3
def: "Bis(sulfosuccinimidyl)suberate." [CAS:82436-77-9, PubChem_Compound:6097991, PMID:12892908, ChemSpiderID:110394, ChemicalBookNo:CB0136444]
synonym: "Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester)" EXACT []
synonym: "Bis(sulfosuccinimidyl)suberate" EXACT []
synonym: "Sulfo-DSS" EXACT []
synonym: "BSSS" EXACT []
synonym: "BS3-d0" EXACT []
synonym: "BS3-H12" EXACT []
property_value: bridgeFormula: "C8 H10 O2" xsd:string
property_value: monoIsotopicMass: "138.06807961" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester

[Term]
id: XLMOD:02001
name: DSS
def: "Disuccinimidyl suberate." [CAS:68528-80-3, PubChem_Compound:100658, PMID:16944939, ChemSpiderID:90944, ChemicalBookNo:CB1219157]
synonym: "Bis(succinimidyl) suberate" EXACT []
synonym: "Suberic acid bis(N-hydroxysuccinimide ester)" EXACT []
synonym: "Disuccinimidyl octanedioate" EXACT []
synonym: "DSS-d0" EXACT []
synonym: "DSS-H12" EXACT []
synonym: "1,1'-[(1,8-Dioxooctane-1,8-diyl)bis(oxy)]dipyrrolidine-2,5-dione" EXACT []
property_value: bridgeFormula: "C8 H10 O2" xsd:string
property_value: monoIsotopicMass: "138.06807961" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02002
name: DSS-d4
def: "Deuterium labelled disuccinimidyl 2,2,7,7-suberate." [PubChem_Compound:91757798, PMID:11354472]
property_value: bridgeFormula: "C8 D4 H6 O2" xsd:string
property_value: doubletDeltaMass: "4.02508" xsd:double
property_value: monoIsotopicMass: "142.093186586" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02003
name: DSS-d12
def: "Deuterium labelled disuccinimidyl 2,2,3,3,4,4,5,5,6,6,7,7-suberate." [PSI:XL, PMID:11354472, PMID:16944939]
property_value: bridgeFormula: "C8 D10 O2" xsd:string
property_value: doubletDeltaMass: "12.07573" xsd:double
property_value: monoIsotopicMass: "150.143400538" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02004
name: BS3-d4
def: "Deuterium labelled (bis(sulfosuccinimidyl) 2,2,7,7-suberate)." [PubChem_Compound:91757801]
property_value: doubletDeltaMass: "4.02508" xsd:double
property_value: monoIsotopicMass: "142.093186586" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02005
name: BS2G
def: "Bis(sulfosuccinimidyl) glutarate." [PubChem_Compound:91757794, ChemicalBookNo:CB91307211]
synonym: "Glutaric acid bis(3-sulfo-N-hydroxysuccinimide ester)" EXACT []
synonym: "Sulfo-DSG" EXACT []
synonym: "Disulfosuccinimidylglutarate" EXACT []
synonym: "DSSG" EXACT []
synonym: "BS2G-d0" EXACT []
property_value: bridgeFormula: "C5 H4 O2" xsd:string
property_value: monoIsotopicMass: "96.0211294" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester

[Term]
id: XLMOD:02006
name: DSG
def: "Disuccinimidyl glutarate." [CAS:79642-50-5, PubChem_Compound:4432628, Beilstein:8575145, MDL:MFCD00153597, ChemSpiderID:3632504, ChemicalBookNo:CB0373852]
synonym: "Di(N-succinimidyl) glutarate" EXACT []
synonym: "Di-succinimidyl glutarate" EXACT []
synonym: "Di N-succinimidyl glutarate" EXACT []
synonym: "Bis-NHS glutarate" EXACT []
synonym: "Disuccinimidyl glutaric dicarboxylate" EXACT []
synonym: "DSG-d0" EXACT []
property_value: bridgeFormula: "C5 H4 O2" xsd:string
property_value: monoIsotopicMass: "96.0211294" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02007
name: DSG-d4
def: "Deuterium labelled disuccinimidyl 2,2,4,4-glutarate." [PubChem_Compound:91757797]
property_value: bridgeFormula: "C5 D4 O2" xsd:string
property_value: doubletDeltaMass: "4.02508" xsd:double
property_value: monoIsotopicMass: "100.046236376" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02008
name: BS2G-d4
def: "Deuterium labelled bis(sulfosuccinimidyl) 2,2,4,4-glutarate." [PubChem_Compound:91757799]
synonym: "DSSG-d4" EXACT []
property_value: bridgeFormula: "C5 D4 O2" xsd:string
property_value: doubletDeltaMass: "4.02508" xsd:double
property_value: monoIsotopicMass: "100.046236376" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02009
name: Disulfide
def: "Disulfide." [PSI:XL]
property_value: bridgeFormula: "-H2" xsd:string
property_value: monoIsotopicMass: "-2.01565007" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: specificities: "(C)&(C)" xsd:string
is_a: XLMOD:00005 ! homofunctional cross-linker
is_a: XLMOD:00008 ! zero-length cross-linker

[Term]
id: XLMOD:02010
name: 1-ethyl-3-(3-Dimethylaminopropyl)carbodiimide hydrochloride
def: "1-ethyl-3-(3-Dimethylaminopropyl)carbodiimide hydrochloride." [CAS:25952-53-8, PubChem_Compound:2723939, Beilstein:5764110, ChemSpiderID:2006116, ChemicalBookNo:CB7403031, MDL:MFCD00012503, PMID:19136724, PMID:3394930]
comment: Used to conjugate carboxyl functional groups to primary amines from peptides and proteins and is ideal for covalently binding proteins or peptides to carboxyl containing beads, resins, or nanoparticles.
synonym: "3-(3-Dimethylaminopropyl)-1-ethyl-carbodiimide hydrochloride" EXACT []
synonym: "EDAC-HCl" EXACT []
synonym: "EDCI" EXACT []
synonym: "EDC-HCl" EXACT []
property_value: bridgeFormula: "-H2 -O1" xsd:string
property_value: monoIsotopicMass: "-18.01056027" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00008 ! zero-length cross-linker
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00105 ! Carbodiimide
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:02011
name: BDP-NHP
def: "Biotin Aspartate Proline n-hydroxyphthalamide." [PSI:XL]
property_value: monoIsotopicMass: "1241.469925525" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: is_cleavable XLMOD:00018 ! cleavable by MS2 labile bond
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00104 ! N-hydroxyphthalimide

[Term]
id: XLMOD:02012
name: ANB-NOS
def: "N-5-Azido-2-nitrobenzoyloxysuccinimide." [CAS:60117-35-3, PubChem_Compound:3080866, Beilstein:1555224, MDL:MFCD00054962, ChemSpiderID:2338587, ChemicalBookNo:CB7381289]
synonym: "N-Succinimidyl 5-azido-2-nitrobenzoate" EXACT []
synonym: "5-Azido-2-nitrobenzoic acid N-hydroxysuccinimide ester" EXACT []
synonym: "N-(5-Azido-2-nitrobenzoyloxy)succinimide" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00107 ! nitrophenyl azide

[Term]
id: XLMOD:02013
name: BMPS
def: "N-(beta-Maleimidopropyloxy)succinimide ester." [CAS:55750-62-4, PubChem_Compound:4620597, Beilstein:1492578, MDL:MFCD00043141, ChemSpiderID:3811455, ChemicalBookNo:CB5780592]
synonym: "N-Succinimidyl 3-maleimidopropionate" EXACT []
synonym: "3-Maleimidopropionic acid N-hydroxysuccinimide ester" EXACT []
property_value: bridgeFormula: "C7 H5 O3 N1" xsd:string
property_value: monoIsotopicMass: "151.026943065" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "6.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02014
name: EMCS
def: "6-Maleimidohexanoic acid N-hydroxysuccinimide ester." [CAS:55750-63-5, PubChem_Compound:5091655, ChemSpiderID:4267588, ChemicalBookNo:CB8212960]
synonym: "N-(epsilon-Malaimidocaproyloxy) succinimide ester" EXACT []
synonym: "6-maleimidohexanoic acid N-hydroxysuccinimide ester" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.4" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02015
name: GMBS
def: "N-[gamma-Maleimidobutyryloxy] succinimide." [CAS:80307-12-6, PubChem_Compound:133440, MDL:MFCD00036817, ChemSpiderID:117712, ChemicalBookNo:CB5267080]
synonym: "4-Maleimdobutyric acid N-succinimidyl ester" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.3" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02016
name: SPDP
def: "N-Succinimidyl 3-[2-pyridyldithio]-propionate." [CAS:68181-17-9, PubChem_Compound:100682, ChemSpiderID:90967, ChemicalBookNo:CB2446059]
synonym: "3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "6.8" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00109 ! pyridinyldisulfide

[Term]
id: XLMOD:02017
name: LC-SPDP
def: "Succinimidyl 6-(3-[2-pyridyldithio]-propionamido)hexanoate." [CAS:158913-22-5, PubChem_Compound:157808, ChemSpiderID:138854, ChemicalBookNo:CB8355139]
synonym: "Long chain-SPDP" EXACT []
synonym: "Succinimidyl 6-(3-(2-Pyridyldithio)propionamido)hexanoate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "15.7" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00109 ! pyridinyldisulfide

[Term]
id: XLMOD:02018
name: Sulfo-LC-SPDP
def: "Sulfosuccinimidyl 6-(3'-[2-pyridyldithio]-propionamido)hexanoate." [CAS:169751-10-4, PubChem_Compound:4588467, ChemSpiderID:3780707, ChemicalBookNo:CB8177681]
synonym: "Sulfo-Long chain-SPDP" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "15.7" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00109 ! pyridinyldisulfide

[Term]
id: XLMOD:02019
name: MBS
def: "m-Maleimidobenzoyl-N-hydroxysuccinimide ester." [CAS:58626-38-3, PubChem_Compound:93861, ChemSpiderID:84714, ChemicalBookNo:CB0342553]
synonym: "3-Maleimidobenzoic acid N-hydroxysuccinimide ester" EXACT []
synonym: "meta-Maleimidobenzoyl-N-hydroxysuccinimide ester" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.3" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02020
name: Sulfo-MBS
def: "m-Maleimidobenzoyl-N-hydroxysulfosuccinimide ester." [CAS:92921-25-0, ChemSpiderID:111159, ChemicalBookNo:CB9338287]
synonym: "3-Maleimidobenzoic acid N-hydroxysulfosuccinimide ester" EXACT []
synonym: "meta-Maleimidobenzoyl-N-hydroxysulfosuccinimide ester" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.3" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02021
name: PDPH
def: "3-[2-Pyridyldithio]propionyl hydrazide." [CAS:115616-51-8, PubChem_Compound:130785, ChemSpiderID:115670, ChemicalBookNo:CB3412468]
synonym: "SPDP Hydrazide" EXACT []
synonym: "S-(2-thiopyridyl)-3-mercaptopropionic acid hydrazide" EXACT []
synonym: "3-(2-pyridyldithio)propionyl hydrazide" EXACT []
synonym: "TPMPH" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.2" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00109 ! pyridinyldisulfide
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:02022
name: SBA
def: "N-Succinimidyl bromoacetate." [CAS:42014-51-7, PubChem_Compound:3565210, ChemSpiderID:2802588, ChemicalBookNo:CB4678610]
synonym: "Bromoacetic acid N-hydroxysuccinimide ester" EXACT []
synonym: "Succinimidyl bromoacetate" EXACT []
synonym: "NHS-Bromoacetate" EXACT []
synonym: "SIB" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "1.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00128 ! bromoacetyl

[Term]
id: XLMOD:02023
name: SIA
def: "N-Succinimidyl iodoacetate." [CAS:39028-27-8, PubChem_Compound:3299230, ChemSpiderID:2547635, ChemicalBookNo:CB9364435]
synonym: "Iodoacetic acid N-hydroxysuccinimide ester" EXACT []
synonym: "Succinimidyl iodoacetate" EXACT []
synonym: "NHS-Iodoacetate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "1.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00127 ! iodoacetyl

[Term]
id: XLMOD:02024
name: SMCC
def: "Succinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate." [CAS:64987-85-5, PubChem_Compound:125175, ChemSpiderID:21173480, ChemicalBookNo:CB6748487]
synonym: "4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester" EXACT []
synonym: "N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate" EXACT []
synonym: "Succinimidyl trans-4-(N-maleimidylmethyl)cyclohexane-1-carboxylate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02025
name: Sulfo-SMCC
def: "Sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate." [CAS:92921-24-9, PubChem_Compound:16219679, ChemSpiderID:3809728, ChemicalBookNo:CB6219112]
synonym: "4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester" EXACT []
synonym: "Sulfosuccinimidyl-4-N-maleimidomethyl-cyclohexane-1-carboxylate" EXACT []
synonym: "SSMCC" EXACT []
synonym: "S-SMCC" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02026
name: SMPB
def: "N-Succinimidyl 4-[4-maleimidophenyl]butyrate." [CAS:79886-55-8, PubChem_Compound:100681, ChemSpiderID:90966, ChemicalBookNo:CB3322684]
synonym: "4-(4-Maleimidophenyl)butyric acid N-hydroxysuccinimide ester" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02027
name: SMPH
def: "Succinimidyl-6-[beta-maleimidopropionamido]hexanoate." [CAS:367927-39-7, PubChem_Compound:4170355, ChemSpiderID:3381798, ChemicalBookNo:CB2100210]
synonym: "Succinimidyl 6-[(3-maleimido)propionamido]-hexanoate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "14.3" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: is_cleavable XLMOD:00041 ! thiol cleavable

[Term]
id: XLMOD:02028
name: Sulfo-SANPAH
def: "N-Sulfosuccinimidyl-6-[4'-azido-2'-nitrophenylamino] hexanoate." [CAS:102568-43-4, PubChem_Compound:3035866, ChemSpiderID:2300000, ChemicalBookNo:CB4457477]
synonym: "1-[6-[(4-azido-2-nitro-phenyl)amino]hexanoyloxy]-2,5-Dioxo-pyrrolidine-3-sulfonic acid" EXACT []
synonym: "Sulfosuccinimidyl 6-((4-azido-2-nitrophenyl)amino)hexanoate" EXACT []
synonym: "Sulfosuccinimidyl 6-((4'-azido-2'-nitrophenyl)amino)hexanoate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "18.2" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00107 ! nitrophenyl azide 

[Term]
id: XLMOD:02029
name: DSP
def: "Dithiobis[succinimidyl propionate." [CAS:57757-57-0, PubChem_Compound:93313, Beilstein:1518074, MDL:MFCD00042045, ChemSpiderID:84243, ChemicalBookNo:CB7251791]
synonym: "3,3'-Dithiodipropionic acid di(N-hydroxysuccinimide ester)" EXACT []
synonym: "Di(N-succinimidyl) 3,3'-Dithiodipropionate" EXACT []
synonym: "Dithiobis-succinimidyl propionate" EXACT []
synonym: "Dithio-bis-succinimidyl propionate" EXACT []
synonym: "Dithiobis(succinimidyl propionate)" EXACT []
synonym: "Lomant's Reagent" EXACT []
synonym: "DTSP" EXACT []
synonym: "DSP-d0" EXACT []
property_value: bridgeFormula: "C6 H6 O2 S2" xsd:string
property_value: monoIsotopicMass: "173.98092087" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "12.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02030
name: DSP-d8
def: "Deuterium labelled Dithiobis[1,1,2,2,2,2,3,3-succinimidyl propionate." [PubChem_Compound:91757796]
property_value: bridgeFormula: "C6 D6 O2 S2" xsd:string
property_value: doubletDeltaMass: "8.05016" xsd:double
property_value: monoIsotopicMass: "182.0314167" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "12.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02031
name: DSSeb
def: "Sebacic acid bis[N-hydroxysuccinimide ester]." [CAS:23024-29-5, PubChem_Compound:3430836, ChemSpiderID:2674029, ChemicalBookNo:CB4402699]
synonym: "Disuccinimidyl sebacate" EXACT []
synonym: "Sebacic acid bis(N-hydroxysuccinimide ester)" EXACT []
synonym: "Di(N-succinimidyl) sebacate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "14.1" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02032
name: DST
def: "Disuccinimidyl tartrate." [CAS:62069-75-4, PubChem_Compound:124912, MDL:MFCD03788224, ChemSpiderID:296442, ChemicalBookNo:CB9243998]
synonym: "Disuccinimidyl L-Tartrate" EXACT []
property_value: bridgeFormula: "C4 H2 O4" xsd:string
property_value: monoIsotopicMass: "113.99531" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "6.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00024 ! periodate cleavable

[Term]
id: XLMOD:02033
name: DTSSP
def: "3,3'-Dithiobis[sulfosuccinimidylpropionate]." [CAS:81069-02-5, PubChem_Compound:123933, MDL:MFCD01861949, ChemSpiderID:110462, ChemicalBookNo:CB31073260, PMID:10975572, PMID:18510349]
synonym: "3,3'-Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester" EXACT []
synonym: "Sulfo-DSP" EXACT []
synonym: "Sulfo-DTSP" EXACT []
synonym: "DTBSSP" EXACT []
synonym: "DTSSP-d0" EXACT []
property_value: bridgeFormula: "C6 H6 O2 S2" xsd:string
property_value: monoIsotopicMass: "173.98093" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "12.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02034
name: EGS
def: "Ethylene glycolbis(succinimidylsuccinate)." [CAS:70539-42-3, PubChem_Compound:123663, ChemSpiderID:110243, ChemicalBookNo:CB5722624]
synonym: "Ethylene glycol bis (succinimidylsuccinate)" EXACT []
synonym: "Ethylene Glycol-Bis (Succinic Acid N-Hydroxysuccinimide Ester)" EXACT []
synonym: "EGS-d0" EXACT []
property_value: bridgeFormula: "C10 H10 O6" xsd:string
property_value: monoIsotopicMass: "226.047738" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "16.1" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00025 ! hydroxylamine cleavable
relationship: is_cleavable XLMOD:00039 ! ammonium cleavable

[Term]
id: XLMOD:02035
name: Sulfo-EGS
def: "Ethylene glycolbis(sulfosuccinimidylsuccinate)." [CAS:167410-92-6, PubChem_Compound:91757793, ChemSpiderID:32034171, ChemicalBookNo:CB4497176]
synonym: "Ethylene glycol bis(sulfosuccinimidylsuccinate)" EXACT []
synonym: "Ethylene Glycol-Bis (Succinic Acid N-Hydroxysulfosuccinimide Ester)" EXACT []
synonym: "Bis(sulfo-N-succinimidyl) ethylene glycol disuccinate" EXACT []
synonym: "Ethylene glycol disuccinate bis(sulfo-N-succinimidyl) ester" EXACT []
synonym: "EGSS" EXACT []
synonym: "EGSS-d0" EXACT []
property_value: bridgeFormula: "C10 H10 O6" xsd:string
property_value: monoIsotopicMass: "226.04774" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "16.1" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00025 ! hydroxylamine cleavable
relationship: is_cleavable XLMOD:00039 ! ammonium cleavable

[Term]
id: XLMOD:02036
name: CDI
def: "N,N'-Carbonyldiimidazole." [CAS:530-62-1, PubChem_Compound:68263, Beilstein:6826, MDL:MFCD00005286, ChemSpiderID:61561, ChemicalBookNo:CB0215374]
comment: Used to convert alcohols and amines into carbamates, esters, and ureas.
synonym: "1,1'-Carbonyldiimidazole" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00008 ! zero-length cross-linker

[Term]
id: XLMOD:02037
name: DCC
def: "N,N'-Dicyclohexylcarbodiimide." [CAS:538-75-0, PubChem_Compound:10868, Beilstein:610662, MDL:MFCD00011659, ChemSpiderID:10408, ChemicalBookNo:CB9706578]
comment: Used for coupling amines and carboxylates without the insertion of spacer atoms.
synonym: "DCCD" EXACT []
synonym: "DCCI" EXACT []
synonym: "Bis(cyclohexyl)carbodiimide" EXACT []
synonym: "Cyclohexaamine, N,N'-methanetetraylbis-(9CI)" EXACT []
synonym: "Dicyclohexylcarbodiimide" EXACT []
synonym: "N,N'-Dicyclohexylcarbodiimide" EXACT []
synonym: "1,3-Dicyclohexylcarbodiimide" EXACT []
synonym: "N,N'-Methanetetrayl biscyclohexanamine" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00008 ! zero-length cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00105 ! Carbodiimide

[Term]
id: XLMOD:02038
name: NHS
def: "N-hydroxysuccinimide." [CAS:6066-82-6, PubChem_Compound:80170, Beilstein:113913, MDL:MFCD00005516, ChemSpiderID:72416, ChemicalBookNo:CB0391283]
comment: Used in conjunction with EDC-HCl (EDAC-HCl) to convert carboxyl groups to NHS esters which react with primary amines.
synonym: "1-Hydroxy-2,5-pyrrolidinedione" EXACT []
is_a: XLMOD:00008 ! zero-length cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable

[Term]
id: XLMOD:02039
name: Sulfo-NHS
def: "N-hydroxysulfosuccinimide." [CAS:106627-54-7, PubChem_Compound:3520574, MDL:MFCD00043100, ChemSpiderID:2759874, ChemicalBookNo:CB9164497]
comment: Used in conjunction with EDC-HCl (EDAC-HCl) to convert carboxyl groups to Sulfo-NHS esters which react with primary amines.
synonym: "Sulfo NHS" EXACT []
synonym: "S-NHS" EXACT []
synonym: "Hydroxy-2,5-Dioxopyrrolidine-3-sulfonicacid" EXACT []
is_a: XLMOD:00008 ! zero-length cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic

[Term]
id: XLMOD:02040
name: BiPS
def: "Bimane bisthiopropionic acid N-succinimidyl ester." [PMID:18838738]
property_value: bridgeFormula: "C16 H16 N2 O4 S2" xsd:string
property_value: monoIsotopicMass: "364.05515" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00034 ! photo cleavable

[Term]
id: XLMOD:02041
name: formaldehyde
def: "Formaldehyde reagent." [CAS:50-00-0, ChemSpiderID:692, ChemicalBookNo:CB4853677, PMID:18438963, PMID:25979347]
property_value: reactionSites: "1" xsd:nonNegativeInteger
property_value: spacerLength: "2.5" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00116 ! aldehyde
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:02042
name: glutardialdehyde
def: "Glutardialdehyde." [CAS:111-30-8, ChemSpiderID:3365, ChemicalBookNo:CB3762723]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00116 ! aldehyde
relationship: is_reactive_with XLMOD:00037 ! non-selective

[Term]
id: XLMOD:02043
name: DSA
def: "Disuccinimidyladipic acid." [CAS:26544-38-7, PubChem_Compound:6438029, ChemSpiderID:4515188, ChemicalBookNo:CB5470426]
synonym: "disuccinimidyl adipate" EXACT []
property_value: bridgeFormula: "C6 H6 O2" xsd:string
property_value: monoIsotopicMass: "110.03624" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02044
name: DNBDPS
def: "An isotopically-coded cleavable crosslinker affinity-purifyable with antibodies." [PMID:20109223]
property_value: bridgeFormula: "C12 H9 N2 O6 S2" xsd:string
property_value: monoIsotopicMass: "339.98238" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00054 ! DNB
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02045
name: TEABS
def: "TEABS cross-linking reagent." [PMID:20109223]
property_value: bridgeFormula: "C28 H39 N5 O11 S1" xsd:string
property_value: monoIsotopicMass: "653.23668" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: is_cleavable XLMOD:00038 ! DTT cleavable
relationship: is_cleavable XLMOD:00039 ! ammonium cleavable

[Term]
id: XLMOD:02046
name: CLIP
def: "Click-enabled linker for interacting proteins." [PMID:19496583]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.5" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00053 ! alkyne
relationship: has_neutral_loss_reporter XLMOD:00052 ! NO2 neutral loss reporter
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02047
name: BDRG
def: "Biotin-aspartate-Rink-glycine cross-linker composed of a biotin affinity handle (B), a pentafluorophenyl (PFP) ester modified aspartate reside (D), a Rink group (R), and a PFP ester modified glycine reside (G)." [PMID:22067100]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: is_cleavable XLMOD:00018 ! cleavable by MS2 labile bond
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00120 ! pentafluorophenyl

[Term]
id: XLMOD:02048
name: DTSSP-d8
def: "Deuterium labelled 3,3'-Dithiobis[sulfosuccinimidylpropionate]." [PMID:10975572, PMID:18510349]
property_value: bridgeFormula: "C6 D6 O2 S2" xsd:string
property_value: doubletDeltaMass: "8.05016" xsd:double
property_value: monoIsotopicMass: "182.03109" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "12.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond
relationship: is_cleavable XLMOD:00035 ! CID cleavable
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02049
name: EGS-d12
def: "Deuterium labelled ethylene glycolbis(succinimidylsuccinate)." [PMID:15901824]
property_value: bridgeFormula: "C10 D10 O6" xsd:string
property_value: doubletDeltaMass: "12.07573" xsd:double
property_value: monoIsotopicMass: "238.12347" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "16.1" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00025 ! hydroxylamine cleavable
relationship: is_cleavable XLMOD:00039 ! ammonium cleavable
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02050
name: Sulfo-EGS-d12
def: "Deuterium labelled ethylene glycolbis(sulfosuccinimidylsuccinate)." [PMID:15901824]
property_value: bridgeFormula: "C10 D10 O6" xsd:string
property_value: doubletDeltaMass: "12.07573" xsd:double
property_value: monoIsotopicMass: "238.12347" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "16.1" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00025 ! hydroxylamine cleavable
relationship: is_cleavable XLMOD:00039 ! ammonium cleavable
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02051
name: PCAS
def: "Pyridine-3-Carboxylic Acid Succinimide." [PMID:20050626, PMID:23085224]
synonym: "PCAS-H4" EXACT []
synonym: "PCAS-d0" EXACT []
synonym: "PCASS" EXACT []
property_value: bridgeFormula: "C6 H3 N1 O1" xsd:string
property_value: monoIsotopicMass: "105.02146" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker

[Term]
id: XLMOD:02052
name: PCAS-d4
def: "Pyridine-3-Carboxylic Acid Succinimide." [PMID:20050626, PMID:23085224]
synonym: "PCASS-d4" EXACT []
property_value: bridgeFormula: "C6 D3 N1 O1" xsd:string
property_value: doubletDeltaMass: "4.02508" xsd:double
property_value: monoIsotopicMass: "109.04812" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02053
name: DSA-13C6
def: "13C labelled disuccinimidyladipic acid." [PSI:XL]
property_value: bridgeFormula: "13C6 H6 O2" xsd:string
property_value: doubletDeltaMass: "6.02016" xsd:double
property_value: monoIsotopicMass: "116.0564" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00036 ! 13C labelled

[Term]
id: XLMOD:02054
name: CBDPS-d8
def: "Deuterium labelled cyanurbiotindipropionylsuccinimide." [PMID:20622150]
property_value: bridgeFormula: "C19 D8 H15 N7 O4 S3" xsd:string
property_value: doubletDeltaMass: "8.05016" xsd:double
property_value: monoIsotopicMass: "517.14698" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "14.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02055
name: CBDPSS
def: "Cyanurbiotindimercaptopropionylsulfosuccinimide." [PMID:20622150]
synonym: "Sulfo-CBDPSS" EXACT []
property_value: bridgeFormula: "C19 H23 N7 O4 S3" xsd:string
property_value: monoIsotopicMass: "509.09682" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "14.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02056
name: CBDPSS-d8
def: "Deuterium labelled cyanurbiotindimercaptopropionylsulfosuccinimide." [PMID:20622150]
property_value: bridgeFormula: "C19 D8 H15 N7 O4 S3" xsd:string
property_value: doubletDeltaMass: "8.05016" xsd:double
property_value: monoIsotopicMass: "517.14698" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "14.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02057
name: SDH
def: "Suberic acid 1,8-dihydrazide." [CAS:20247-84-1, PMID:24938783, ChemSpiderID:520361, ChemicalBookNo:CB8664268]
property_value: bridgeFormula: "C8 H14 N4" xsd:string
property_value: monoIsotopicMass: "166.12184649" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:02058
name: SDH-d12
def: "Deuterium labelled suberic acid 1,8-dihydrazide." [PMID:24938783]
property_value: bridgeFormula: "C8 D12 H2 N4" xsd:string
property_value: doubletDeltaMass: "12.07573" xsd:double
property_value: monoIsotopicMass: "178.1971667418" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02059
name: ADH
def: "Adipic acid 1,6-dihydrazide." [CAS:1071-93-8, ChemSpiderID:59505, ChemicalBookNo:CB4129556, PMID:24938783]
property_value: bridgeFormula: "C6 H10 N4" xsd:string
property_value: monoIsotopicMass: "138.09054635" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:02060
name: ADH-d8
def: "Deuterium labelled adipic acid 1,6-dihydrazide." [PMID:24938783]
property_value: bridgeFormula: "C6 D8 H2 N4" xsd:string
property_value: doubletDeltaMass: "8.05016" xsd:double
property_value: monoIsotopicMass: "146.140760302" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02061
name: GDH
def: "Glutaric acid 1,5-dihydrazide." [CAS:1508-67-4, ChemSpiderID:3179469, ChemicalBookNo:CB4453510, PMID:24938783]
property_value: bridgeFormula: "C5 H8 N4" xsd:string
property_value: monoIsotopicMass: "124.07489628" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:02062
name: GDH-d6
def: "Deuterium labelled glutaric acid 1,5-dihydrazide." [PMID:24938783]
property_value: bridgeFormula: "C5 D6 H2 N4" xsd:string
property_value: doubletDeltaMass: "6.04368" xsd:double
property_value: monoIsotopicMass: "130.112556744" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02063
name: BS3-d12
def: "Deuterium labelled (bis(sulfosuccinimidyl) 2,2,3,3,4,4,5,5,6,6,7,7-suberate)." [PSI:XL]
property_value: doubletDeltaMass: "12.07573" xsd:double
property_value: monoIsotopicMass: "150.14381" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02064
name: DSG-d6
def: "Deuterium labelled disuccinimidyl 2,2,3,3,4,4-glutarate." [PSI:XL]
property_value: bridgeFormula: "C5 D6 O2" xsd:string
property_value: doubletDeltaMass: "6.02016" xsd:double
property_value: monoIsotopicMass: "102.05821" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02065
name: BS2G-d6
def: "Deuterium labelled bis(sulfosuccinimidyl) 2,2,3,3,4,4-glutarate." [PSI:XL]
synonym: "DSSG-d6" EXACT []
property_value: bridgeFormula: "C5 D4 O2" xsd:string
property_value: doubletDeltaMass: "4.02508" xsd:double
property_value: monoIsotopicMass: "100.046236376" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02066
name: SATA
def: "Succinimidyl acetylthioacetate." [CAS:76931-93-6, PubChem_Compound:127532, ChemSpiderID:113145, ChemicalBookNo:CB6378192]
synonym: "N-succinimidyl S-acetylthioacetate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "2.8" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00144 ! S-acetyl
relationship: is_cleavable XLMOD:00025 ! hydroxylamine cleavable

[Term]
id: XLMOD:02067
name: SATP
def: "N-succinimidyl-S-acetylthiopropionate." [CAS:84271-78-3, PubChem_Compound:4110341, ChemSpiderID:3324023, ChemicalBookNo:CB7151156]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "4.1" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00144 ! S-acetyl
relationship: is_cleavable XLMOD:00025 ! hydroxylamine cleavable

[Term]
id: XLMOD:02068
name: LC-SMCC
def: "Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxy-(6-amidocaproate)." [CAS:125559-00-4, PubChem_Compound:3564731, ChemSpiderID:2802130, ChemicalBookNo:CB2681973]
synonym: "Long chain-SMCC" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "16.2" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02069
name: PEAS
def: "N-((2-pyridyldithio)ethyl)-4-azidosalicylamide." [MDL:MFCD00467787, PMID:11320237]
synonym: "AES" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00109 ! pyridinyldisulfide
relationship: has_reactive_group XLMOD:00114 ! aryl azide

[Term]
id: XLMOD:02070
name: BisEA
def: "Bis-(2-(Methanethiosulfonato)ethyl)amine." [PSI:XL]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02071
name: 3,6,9,12-Tetraoxatetradecane-1,14-diyl dimethanethiosulfonate
def: "3,6,9,12-Tetraoxatetradecane-1,14-diyl dimethanethiosulfonate cross-linker." [CAS:212262-08-3, PubChem_Compound:46783053, ChemSpiderID:3765062, ChemicalBookNo:CB4773508]
synonym: "3,6,9,12-Tetraoxatetradecane-1,14-diyl-bis-methanethiosulfonate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02072
name: 3,6,9-Trioxaundecane-1,11-diyl dimethanethiosulfonate
def: "3,6,9-Trioxaundecane-1,11-diyl dimethanethiosulfonate cross-linker." [CAS:212262-02-7, PubChem_Compound:5047788, ChemSpiderID:57565984, ChemicalBookNo:CB41175710]
synonym: "3,6,9-Trioxaundecane-1,11-diyl-bismethanethiosulfonate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02073
name: MTS-1-MTS
def: "1,1-Methanediyl Bismethanethiosulfonate." [CAS:22418-52-6, PubChem_Compound:4251850, ChemSpiderID:3459853, ChemicalBookNo:CB01175439]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02074
name: MTS-2-MTS
def: "1,2-Ethanediyl Bismethanethiosulfonate." [CAS:55-95-8, PubChem_Compound:564320, MDL:MFCD01320400, ChemSpiderID:490602, ChemicalBookNo:CB31175450]
synonym: "1,2-Ethanedithiol Dimethanesulfonate" EXACT []
synonym: "Preparation 289" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02075
name: MTS-6-NHS
def: "N-Succinimidyloxycarbonylpentyl methanethiosulfonate." [CAS:76078-81-4, PubChem_Compound:3614736, ChemSpiderID:2849984, ChemicalBookNo:CB6747738]
synonym: "6-[(Methanethisulfonyl)thio]hexanoic acid, N-succinimidyl ester" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02076
name: MTS-8-O2-MTS
def: "3,6-dioxaoctane-1,8-diyl dimethanethiosulfonate." [CAS:212262-04-9, PubChem_Compound:3332000, ChemSpiderID:2579076, ChemicalBookNo:CB01175712]
synonym: "1,2-bis(2-methylsulfonylsulfanylethoxy)ethane" EXACT []
synonym: "3,6-Dioxaoctane-1,8-diyl Bismethanethiosulfonate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02077
name: MTS-11-MTS
def: "Undecane-1,11-diyl-bismethanethiosulfonate." [PSI:XL]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02078
name: BSOCOES
def: "Bis(2-[Succinimidooxycarbonyloxy]ethyl) sulfone." [CAS:57683-72-4, PubChem_Compound:93771, ChemSpiderID:84638, ChemicalBookNo:CB6488705]
property_value: bridgeFormula: "C6 H6 O6 S1" xsd:string
property_value: monoIsotopicMass: "205.988512" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "13.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00061 ! base cleavable

[Term]
id: XLMOD:02079
name: DPDPB
def: "1,4-Di-(3'-[2'pyridyldithio]-propionamido) butane." [CAS:141647-62-3, PubChem_Compound:4187644, MDL:MFCD00153604, ChemSpiderID:3398412, ChemicalBookNo:CB1775965]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "19.9" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00109 ! pyridinyldisulfide

[Term]
id: XLMOD:02080
name: Sulfo-DST
def: "Sulfodisuccinimidyl tartrate." [CAS:118674-04-7, PubChem_Compound:3081171, ChemSpiderID:2338831, ChemicalBookNo:CB2297174]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "6.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00024 ! periodate cleavable

[Term]
id: XLMOD:02081
name: Sulfo-GMBS
def: "N-gamma-Maleimidobutyryloxysulfosuccinimide ester." [CAS:185332-92-7, PubChem_Compound:23683309, ChemSpiderID:2678121, ChemicalBookNo:CB4412935]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "6.8" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02082
name: EMCH
def: "N-(epsilon-Maleimidocaproic acid) hydrazide." [CAS:81186-33-6, PubChem_Compound:4170354, ChemSpiderID:3381797, ChemicalBookNo:CB1298684]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.8" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:02083
name: EMCH-TFA
def: "N-(epsilon-Maleimidocaproic acid)hydrazide, TriFluoroacetic Acid." [CAS:151038-94-7, PubChem_Compound:23509306, ChemSpiderID:11567960, ChemicalBookNo:CB8349886]
synonym: "2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic Acid Hydrazide 2,2,2-Trifluoroacetate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.8" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:02084
name: Sulfo-EMCS
def: "N-(epsilon-Maleimidocaproyloxy) sulfo succinimide ester." [CAS:215312-86-0, PubChem_Compound:4229287, ChemSpiderID:3438266, ChemicalBookNo:CB6793735]
synonym: "6-Maleimidocaproic Acid Sulfo-N-Succinimidyl Ester" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.4" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02085
name: PMPI
def: "N-(Maleimidophenyl) isocyanate." [CAS:123457-83-0, PubChem_Compound:129975, ChemSpiderID:115040, ChemicalBookNo:CB7497652]
synonym: "N-(4-Isocyanatophenyl)maleimide" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "8.7" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00124 ! isocyanate

[Term]
id: XLMOD:02086
name: SIAB
def: "N-Succinimidyl(4-iodoacetyl)aminobenzoate." [CAS:72252-96-1, PubChem_Compound:126367, ChemSpiderID:112308, ChemicalBookNo:CB4386384]
synonym: "4-[(2-Iodoacetyl)amino]benzoic Acid 2,5-dioxo-1-pyrrolidinyl Ester" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "10.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00127 ! iodoacetyl

[Term]
id: XLMOD:02087
name: Sulfo-SIAB
def: "N-Sulfosuccinimidyl(4-iodoacetyl)aminobenzoate." [CAS:144650-93-1, PubChem_Compound:4131104, ChemSpiderID:3343983, ChemicalBookNo:CB3328358]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "10.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00127 ! iodoacetyl

[Term]
id: XLMOD:02088
name: Sulfo-SMPB
def: "Sulfo succinimidyl 4-(maleimidophenyl) butyrate." [CAS:92921-26-1, PubChem_Compound:118855953, ChemSpiderID:32076952, ChemicalBookNo:CB5324783]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02089
name: MAL-PEG4-SCM
def: "Succinimidyl-[(N-maleimidopropionamido)-tetraethyleneglycol] ester." [CAS:756525-99-2, PubChem_Compound:51340950, ChemSpiderID:32055651, ChemicalBookNo:CB22546917]
synonym: "NHS-PEG4-Maleimide" EXACT []
synonym: "Mal-PEG4-NHS-ester" EXACT []
synonym: "Maleimide-PEG4-NHS" EXACT []
synonym: "Malamido-PEG4-NHS" EXACT []
synonym: "SM[PEG]4" EXACT []
synonym: "O-[N-(3-Maleimidopropionyl)aminoethyl]-O'-[3-(N-succinimidyloxy)-3-oxopropyl]triethylene glycol" EXACT []
synonym: "Succinimidyl-[(N-maleimidopropionamido)-dodecaethyleneglycol] ester" EXACT []
property_value: hydrophilicPEGchain: "4" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "24.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02090
name: ABH
def: "Azidobenzoyl hydrazide." [CAS:63296-32-2, PubChem_Compound:9812912, ChemSpiderID:7988662, ChemicalBookNo:CB0135326]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: has_reactive_group XLMOD:00126 ! phenyl azide

[Term]
id: XLMOD:02091
name: APG
def: "p-Azidophenyl glyoxal monohydrate." [CAS:1196151-49-1, MDL:MFCD00150595, ChemSpiderID:11564450, ChemicalBookNo:CB3774159]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.3" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00126 ! phenyl azide
relationship: has_reactive_group XLMOD:00142 ! phenylglyoxal

[Term]
id: XLMOD:02092
name: APDP
def: "4-Azido-2-hydroxy-N-(4-{[3-(2-pyridinyldisulfanyl)propanoyl]amino}butyl)benzamide." [ChemSpiderID:8496824, ChemicalBookNo:CB7382675]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "21.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_property XLMOD:00020 ! iodinatable
relationship: has_reactive_group XLMOD:00109 ! pyridinyldisulfide
relationship: has_reactive_group XLMOD:00125 ! hydroxyphenyl azide
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02093
name: BASED
def: "Bis(beta-[4-azidosalicylamido]-ethyl) disulfide." [CAS:199804-21-2, PubChem_Compound:3658531, ChemSpiderID:2891936, ChemicalBookNo:CB3363805]
synonym: "Bis(2-(4-azidosalicylamido)ethyl) disulfide" EXACT []
synonym: "N, N'-(Dithiobis-ethylene)bis(4-azido-2-hydroxy-benzamide)" EXACT []
synonym: "N,N'-Bis(4-azidosalicoyl)cystamine" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "21.3" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_property XLMOD:00020 ! iodinatable
relationship: has_reactive_group XLMOD:00125 ! hydroxyphenyl azide
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02094
name: NHS-ASA
def: "N-Hydroxysuccinimidyl-4-azidosalicyclic acid." [CAS:96602-46-9, PubChem_Compound:3035647, ChemSpiderID:2299834, PMID:2358439, ChemicalBookNo:CB21334997]
synonym: "1-[(4-Azido-2-hydroxybenzoyl)oxy]-2,5-pyrrolidinedione" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "8.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_property XLMOD:00020 ! iodinatable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00125 ! hydroxyphenyl azide

[Term]
id: XLMOD:02095
name: Sulfo-HSAB
def: "N-Hydroxysulfosuccinimidyl-4-azidobenzoate." [CAS:199804-22-3, PubChem_Compound:10290999, ChemSpiderID:8466468, ChemicalBookNo:CB5222018]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00126 ! phenyl azide

[Term]
id: XLMOD:02096
name: Sulfo-SAED
def: "Sulfosuccinimidyl 2-(7-amino-4-methylcoumarin-3-acetamido)ethyl-1,3-dithiopropionate." [PubChem_Compound:132249, ChemSpiderID:116802]
synonym: "2-SAED" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "23.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00135 ! azido-methylcoumarin
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02097
name: Sulfo-SAND
def: "Sulfosuccinimidyl 2-(m-azido-o-nitrobenzamido)-ethyl-1,3'-dithiopropionate." [MDL:MFCD02091654]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "18.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00107 ! nitrophenyl azide 
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02098
name: SANPAH
def: "N-Succinimidyl 6-(4-azido-2-nitroanilino)hexanoate." [CAS:64309-05-3, PubChem_Compound:3035550, ChemSpiderID:2299761, ChemicalBookNo:CB2262231]
synonym: "6-(4-Azido-2-nitrophenylamino)hexanoic acid N-hydroxysuccinimide ester" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "18.2" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00107 ! nitrophenyl azide 

[Term]
id: XLMOD:02099
name: Sulfo-SADP
def: "Sulfosuccinimidyl (4-azidophenyl)-1,3'-dithiopropionate." [CAS:102568-45-6, PubChem_Compound:128116, ChemSpiderID:113597, ChemicalBookNo:CB9210802]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "13.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00126 ! phenyl azide
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02100
name: SASD
def: "Succinimidyl-2-(azidosalicylamido)ethyl-1,3-dithiopropionate." [CAS:144650-95-3, PubChem_Compound:4071585, ChemSpiderID:3286667, ChemicalBookNo:CB9276943]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "18.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_property XLMOD:00020 ! iodinatable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00125 ! hydroxyphenyl azide
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02101
name: Sulfo-SASD
def: "Sulfosuccinimidyl-2-(azidosalicylamido)ethyl-1,3-dithiopropionate." [CAS:144650-95-3, PubChem_Compound:6098351, ChemSpiderID:3286667, ChemicalBookNo:CB9276943]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "18.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_property XLMOD:00020 ! iodinatable
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00125 ! hydroxyphenyl azide
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02102
name: DTTDPS
def: "DTTDPS cross-linker." [PMID:20109223]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00024 ! periodate cleavable

[Term]
id: XLMOD:02103
name: 1,4-diacetalbenzene
def: "1,4-diacetalbenzene reagent." [CAS:1074-12-0, PubChem_Compound:14090, ChemSpiderID:13470, ChemicalBookNo:CB3357077, PMID:18936057, PMID:16875836]
synonym: "Phenyldiglyoxal" EXACT []
synonym: "PDG" EXACT []
property_value: monoIsotopicMass: "190.027" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.5" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00115 ! glyoxal

[Term]
id: XLMOD:02104
name: DiBMADPS
def: "Bis(2,5-dioxopyrrolidin-1-yl)3,3'-(3,5-dibromo-4-methylphenylazanediyl)diproponate." [https://getd.libs.uga.edu/pdfs/hoffman_lisabeth_l_201008_phd.pdf]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable
relationship: is_labelled XLMOD:00044 ! mass defect labelled

[Term]
id: XLMOD:02105
name: DiBBSIAS
def: "Bis(2,5-dioxopyrrolidin-1-yl) 2,2'-(2,4-dibromophenylsulfonylazanediyl)diacetate." [https://getd.libs.uga.edu/pdfs/hoffman_lisabeth_l_201008_phd.pdf]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable
relationship: is_labelled XLMOD:00044 ! mass defect labelled

[Term]
id: XLMOD:02106
name: BID
def: "N-benzyliminodiacetoyloxysuccinimid." [PMID:11212007]
property_value: CID_Fragment: "91" xsd:double
property_value: CID_Fragment: "275.1" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02107
name: BCCL1
def: "Bis-(N-hydroxysuccinimidyl) 3-amino-N-biotinoyl-1,5-pentanedioate." [PMID:19412923]
property_value: monoIsotopicMass: "337.10962" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02108
name: BCCL2
def: "Bis-(N-hydroxysuccinimidyl) 5-amino-N-biotinoyl-1,9-nonanedioate." [PMID:19412923]
property_value: monoIsotopicMass: "393.17222" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02109
name: SBC
def: "N-succinimidyl p-benzoyldihydrocinnamate." [PMID:19653199, ChemSpiderID:4488161]
property_value: monoIsotopicMass: "236.09" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00119 ! benzophenone

[Term]
id: XLMOD:02110
name: SBDC
def: "Deuterium labelled N-succinimidyl p-benzoyldihydrocinnamate." [PMID:19653199]
synonym: "SBC-d2" EXACT []
property_value: doubletDeltaMass: "2.01254" xsd:double
property_value: monoIsotopicMass: "238.10" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00119 ! benzophenone
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02111
name: S-Methyl 5,5'-thiodipentanoylhydroxysuccinimidemethylsulfate
def: "S-Methyl 5,5'-thiodipentanoylhydroxysuccinimidemethylsulfate cross-linker." [PMID:19551991]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02112
name: SuDP
def: "Bisuccinimidyl-succinamyl-aspartyl-proline." [PMID:26091612, PMID:20560670, PMID:17134140]
synonym: "Disuccinimidyl-succinamyl-aspartyl-proline" EXACT []
property_value: CID_Fragment: "97.0528" xsd:double
property_value: CID_Fragment: "197.0324" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.2" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02113
name: SuDPG
def: "Bisuccinimidyl-succinamyl-aspartyl-prolyl-glycine." [PMID:26091612, PMID:17134140]
synonym: "Disuccinimidyl-succinamyl-aspartyl-prolyl-glycine" EXACT []
property_value: CID_Fragment: "97.1" xsd:double
property_value: CID_Fragment: "154.1" xsd:double
property_value: CID_Fragment: "197.1" xsd:double
property_value: CID_Fragment: "215.1" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "15.1" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02114
name: IRCX
def: "Dibenzoyloxysuccinimidylethyl phosphate." [PMID:18517224]
comment: An IR chromogenic crosslinker.
property_value: monoIsotopicMass: "330.0" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "16" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02115
name: BAMG
def: "Bis(succinimidyl)-3-azidomethyl glutarate." [PMID:17600791]
property_value: monoIsotopicMass: "125.048" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.5" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00042 ! TCEP cleavable

[Term]
id: XLMOD:02116
name: azide-DSG
def: "Bis(succinimidyl)-3-azidomethyl glutarate." [PMID:20472459]
property_value: monoIsotopicMass: "211.0" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00055 ! azide
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02117
name: 1
def: "Crosslinking reagent 1." [PMID:14698174]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "8.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02118
name: JMV 3378
def: "Crosslinking reagent JMV 3378." [PMID:19902427]
property_value: monoIsotopicMass: "268.0" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00056 ! CHCA
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02119
name: BuTuGPG
def: "4-[3-(2-{2-[(2,5-dioxo-pyrrolidin-1-yloxycarbonyl-methyl)-carbamoyl]-pyrrolidin-1-yl}-2-oxo-ethyl)-thioureido]-butyric acid 2,5-dioxo-pyrrolidin-1-yl ester." [PMID:19950134]
synonym: "NHS-butyric acid-thiourea-glycine-proline-glycine-NHS" EXACT []
synonym: "NHS-BuTuGPG-NHS" EXACT []
synonym: "Edman linker" EXACT []
property_value: monoIsotopicMass: "1686.84" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "16.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02120
name: BuUrBu
def: "NHS-amino butyric acid-urea-amino butyric acid-NHS." [CAS:1240387-33-0, PubChem_Compound:86106597, ChemSpiderID:65999926, PMID:30074391, PMID:21157862, PMID:20704385, PMID:25261217, PMID:27428000]
synonym: "NHS-BuUrBu-NHS" EXACT []
synonym: "Disuccinimidyl dibutyric urea" EXACT []
synonym: "DSBU" EXACT []
property_value: CID_Fragment: "85.053" xsd:double
property_value: CID_Fragment: "111.032" xsd:double
property_value: doubletDeltaMass: "25.979" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "12.5" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_neutral_loss_reporter XLMOD:00057 ! generic neutral loss reporter
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02121
name: DPS
def: "Diphtalimide suberate." [PMID:19994840]
comment: Contains an eight-carbon spacer arm.
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00104 ! N-hydroxyphthalimide

[Term]
id: XLMOD:02122
name: SBBT
def: "1,1'-(suberoyldioxy)bisbenzotriazole." [PMID:19994840]
comment: Contains an eight-carbon spacer arm.
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00129 ! hydroxybenzotriazole

[Term]
id: XLMOD:02123
name: SBAT
def: "1,1'-(suberoyldioxy)bisazabenzotriazole." [PMID:19994840]
comment: Contains an eight-carbon spacer arm.
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00130 ! 1-hydroxy-7-azabenzotriazole

[Term]
id: XLMOD:02124
name: SDAD
def: "Succinimidyl 2-([4,4'-azipentanamido]ethyl)-1,3'-dithiopropionate." [PMID:20635431, PMID:25251153]
synonym: "NHS-SS-Diazirine" EXACT []
property_value: monoIsotopicMass: "273.0" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "13.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_neutral_loss_reporter XLMOD:00057 ! generic neutral loss reporter
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00103 ! diazirine
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02125
name: Sulfo-SDAD
def: "Sulfosuccinimidyl 2-([4,4'-azipentanamido]ethyl)-1,3'-dithiopropionate." [CAS:1226983-32-9, PubChem_Compound:124202976]
synonym: "Sulfo-NHS-SS-Diazirine" EXACT []
property_value: monoIsotopicMass: "273.0" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "13.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_neutral_loss_reporter XLMOD:00057 ! generic neutral loss reporter
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00103 ! diazirine
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02126
name: DSSO
def: "Disuccinimidyl sulfoxide." [PubChem_Compound:86106597, ChemSpiderID:65999926, PMID:20736410, PMID:27417384]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "10.1" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00067 ! CID cleavable C-S bond

[Term]
id: XLMOD:02127
name: DEST
def: "Diethylsuberthioimidate." [PubChem_Compound:88869905, ChemSpiderID:67491002, PMID:20795639, PMID:22460622]
property_value: bridgeFormula: "C8 H12 N2" xsd:string
property_value: monoIsotopicMass: "136.10004842" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00131 ! thioimidate
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02128
name: cis-Diamminedichloroplatinum (II)
def: "Cis-[Pt(NH3)2Cl2]." [CAS:15663-27-1, PubChem_Compound:441203, ChemSpiderID:76401, ChemicalBookNo:CB9236183, PMID:21591778, PMID:16875836]
synonym: "Cis-platin" EXACT []
synonym: "CPT" EXACT []
property_value: monoIsotopicMass: "225.995" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "4.63" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00132 ! platinum(II)

[Term]
id: XLMOD:02129
name: DC4
def: "DC4 cross-linker containing a DABCO (1,4-diazabicyclo[2.2.2]octane) moiety." [CAS:1374647-94-5, ChemSpiderID:29763722, ChemicalBookNo:CB63152601, PMID:22131227]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "18.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00018 ! cleavable by MS2 labile bond
relationship: is_cleavable XLMOD:00035 ! CID cleavable
relationship: is_cleavable XLMOD:00040 ! ISD cleavable

[Term]
id: XLMOD:02130
name: ASBA
def: "4-(p-Azidosalicylamido)butylamine." [MDL:MFCD00153599, ChemSpiderID:8013538, ChemicalBookNo:CB0295398]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "16.3" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_property XLMOD:00020 ! iodinatable
relationship: has_reactive_group XLMOD:00125 ! hydroxyphenyl azide
relationship: has_reactive_group XLMOD:00133 ! amine reactive group

[Term]
id: XLMOD:02131
name: SPB
def: "Succinimidyl-[4-(psoralen-8-yloxy)]-butyrate." [CAS:129211-47-8, PubChem_Compound:15950836, MDL:MFCD01868521, ChemicalBookNo:CB5449965]
synonym: "NHS-Psoralen" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "8.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00134 ! psoralen

[Term]
id: XLMOD:02132
name: Sulfo-NHS-LC-ASA
def: "Sulfosuccinimidyl(4-azido-salicylamido) hexanoate." [CAS:184533-12-8, PubChem_Compound:10162222, ChemSpiderID:8337730, ChemicalBookNo:CB8475750]
synonym: "Sulfo-NHS-Long Chain-ASA" EXACT []
synonym: "SAH" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "18.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00020 ! iodinatable
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00125 ! hydroxyphenyl azide

[Term]
id: XLMOD:02133
name: Sulfo-SFAD
def: "Sulfosuccinimidyl(perfluoroazidobenzamido)ethyl-1,3´-dithiopropionate." [CAS:220446-74-2, PubChem_Compound:90471066, ChemSpiderID:30798432, ChemicalBookNo:CB9178443]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "14.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00136 ! perfluoroaryl azide
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02134
name: SDA
def: "Succinimidyl-ester diazirine." [PubChem_Compound:89937136, MDL:MFCD28899672]
synonym: "NHS-Diazirine" EXACT []
property_value: bridgeFormula: "C5 H6 O1" xsd:string
property_value: monoIsotopicMass: "82.04186484" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "3.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00103 ! diazirine

[Term]
id: XLMOD:02135
name: LC-SDA
def: "NHS-LC-Diazirine." [PSI:XL]
synonym: "NHS-LC-Diazirine" EXACT []
synonym: "Long Chain-SDA" EXACT []
synonym: "Succinimidyl 6-(4,4'-azipentanamido)hexanoate" EXACT []
property_value: bridgeFormula: "C11 H12 N1 O2" xsd:string
property_value: monoIsotopicMass: "195.125928855" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "12.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00103 ! diazirine

[Term]
id: XLMOD:02136
name: Sulfo-SDA
def: "Sulfo-NHS-Diazirine." [PubChem_Compound:121371016, PMID:28430416]
synonym: "Sulfosuccinimidyl 4,4'-azipentanoate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "3.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00103 ! diazirine
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:02137
name: Sulfo-LC-SDA
def: "Sulfo-NHS-LC-Diazirine." [CAS:1909307-62-5, PubChem_Compound:124202974, MDL:MFCD28899432]
synonym: "Sulfosuccinimidyl 6-(4,4'-azipentanamido)hexanoate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "12.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00103 ! diazirine

[Term]
id: XLMOD:02138
name: DMA
def: "Dimethyl adipimidate dihydrochloride." [CAS:14620-72-5, PubChem_Compound:25738, ChemSpiderID:34991296, ChemicalBookNo:CB4714688]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "8.6" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00111 ! imidoester

[Term]
id: XLMOD:02139
name: DMP
def: "Dimethyl pimelimidate dihydrochloride." [CAS:58537-94-3, PubChem_Compound:11402688, ChemSpiderID:10637821, ChemicalBookNo:CB7380424]
synonym: "Dimethyl pimelinediimidate dihydrochloride" EXACT []
property_value: bridgeFormula: "C7 H10 N2" xsd:string
property_value: monoIsotopicMass: "122.08439835" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.2" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00111 ! imidoester

[Term]
id: XLMOD:02140
name: DMS
def: "Dimethyl suberimidate dihydrochloride." [CAS:34490-86-3, PubChem_Compound:118696, ChemicalBookNo:CB9142806]
synonym: "Dimethyl ester octanediimidic acid dihydrochloride" EXACT []
synonym: "1,8-Dimethoxyoctane-1,8-diyldiammonium dichloride" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00111 ! imidoester

[Term]
id: XLMOD:02141
name: DTBP
def: "Dimethyl 3,3'-dithiobispropionimidate dihydrochloride." [CAS:38285-78-8, PubChem_Compound:123988, ChemSpiderID:10628577, ChemicalBookNo:CB5208751]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.9" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00111 ! imidoester
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02142
name: Sulfo-BSOCOES
def: "Bis(2-[Sulfosuccinimidooxycarbonyloxy]ethyl) sulfone." [CAS:161011-72-9, PubChem_Compound:10232304, ChemicalBookNo:CB62131214, PMID:7356718]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "13.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00061 ! base cleavable

[Term]
id: XLMOD:02143
name: BMH
def: "1,6-Bis-maleimidohexane." [CAS:4856-87-5, PubChem_Compound:20992, ChemSpiderID:19746, ChemicalBookNo:CB9745265]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "16.1" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02144
name: DFDNB
def: "1-5-Difluoro-2,4-dinitrobenzene." [CAS:327-92-4, PubChem_Compound:67598, ChemSpiderID:60919, ChemicalBookNo:CB2488813]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "3.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
is_a: XLMOD:09243 ! Sanger type reagent
relationship: has_reactive_group XLMOD:00145 ! aryl halide

[Term]
id: XLMOD:02145
name: SMPT
def: "4-Succinimidyloxycarbonyl-methyl-alpha-(2-pyridyldithio)toluene." [CAS:112241-19-7, PubChem_Compound:130706, MDL:MFCD00083161, ChemSpiderID:115608, ChemicalBookNo:CB5359464]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.2" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00109 ! pyridinyldisulfide

[Term]
id: XLMOD:02146
name: SDBP
def: "N-hydroxysuccinimidyl-2-3-dibromopropionate." [CAS:118790-78-6, PubChem_Compound:195278, ChemSpiderID:169350, ChemicalBookNo:CB61318997]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00128 ! bromoacetyl

[Term]
id: XLMOD:02147
name: HSAB
def: "N-hydroxysuccinimidyl 4-azidobenzoate." [CAS:53053-08-0, PubChem_Compound:122153, MDL:MFCD00054963, ChemSpiderID:108951, ChemicalBookNo:CB5187007]
synonym: "4-Azidobenzoyloxysuccinimide" EXACT []
synonym: "2,5-dioxopyrrolidin-1-yl) 4-azidobenzoate" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00126 ! phenyl azide

[Term]
id: XLMOD:02148
name: ASIB
def: "1-(p-azidosalicylamido)-4-(iodoacetamido)butane." [PubChem_Compound:10002006, ChemSpiderID:8177587, ChemicalBookNo:CB3741230]
synonym: "1-(4-Azidosalicylamido)-4-(iodoacetamido)butane" EXACT []
synonym: "4-Azido-2-hydroxy-N-{4-[(iodoacetyl)amino]butyl}benzamide" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "18.8" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00126 ! phenyl azide
relationship: has_reactive_group XLMOD:00127 ! iodoacetyl

[Term]
id: XLMOD:02149
name: SAND
def: "Succinimidyl-2-[m-azido-o-nitrobenzamido]ethyl-1,3'-dithiopropionate." [MDL:MFCD02091654]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "18.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00107 ! nitrophenyl azide
relationship: is_cleavable XLMOD:00041 ! thiol cleavable

[Term]
id: XLMOD:02150
name: SADP
def: "N-Succinimidyl (4-azidophenyl) 1,3´-dithiopropionate." [CAS:74676-98-5, PubChem_Compound:494250, ChemSpiderID:432600, ChemicalBookNo:CB7748141]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "13.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00126 ! phenyl azide
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02151
name: PNP-DTP
def: "p-nitrophenyl-2-diazo-3,3,3-trifluoropropionate." [CAS:59733-94-7, PubChem_Compound:5748175, ChemSpiderID:11489106, ChemicalBookNo:CB41358102]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "10.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_property XLMOD:00020 ! iodinatable
relationship: has_reactive_group XLMOD:00107 ! nitrophenyl azide
relationship: has_reactive_group XLMOD:00137 ! diazo group

[Term]
id: XLMOD:02152
name: SAED
def: "Succinimidyl-2-(7-azido-4-methylcoumarin-3-acetamido)ethyl-1,3'-dithiopropionate." [CAS:139609-20-4,PubChem_Compound:90469951, ChemSpiderID:52563941, ChemicalBookNo:CB5455874, PMID:1597185]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "23.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00102 ! Sulfo-NHS ester
relationship: has_reactive_group XLMOD:00135 ! azido-methylcoumarin
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02153
name: Sulfo-SAMCA
def: "Sulfosuccinimidyl-7-azido-4-methylcoumarin-3-acetate." [CAS:223572-57-4, PubChem_Compound:10137892, ChemSpiderID:8313404, ChemicalBookNo:CB02702784]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "12.8" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00135 ! azido-methylcoumarin

[Term]
id: XLMOD:02154
name: MSA
def: "Methyl N-succinimidyl adipate." [CAS:118380-06-6, PubChem_Compound:4458286, ChemSpiderID:3657094, ChemicalBookNo:CB3716645]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.2" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02155
name: Maleimide-PEG2-NHS
def: "Succinimidyl-[(N-maleimidopropionamido)-diethyleneglycol] ester." [CAS:955094-26-5, PubChem_Compound:51340948, MDL:MFCD11041137, ChemSpiderID:32055652, ChemicalBookNo:CB22501435]
synonym: "NHS-PEG2-Maleimide" EXACT []
synonym: "Malamido-PEG2-NHS" EXACT []
synonym: "Succinimide-Maleimide PEG" EXACT []
synonym: "SM[PEG]2" EXACT []
property_value: hydrophilicPEGchain: "2" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "17.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02156
name: Maleimide-PEG6-NHS
def: "Succinimidyl-[(N-maleimidopropionamido)-hexaethyleneglycol] ester." [CAS:1137109-21-7, PubChem_Compound:77078209, MDL:MFCD11041093, ChemSpiderID:32055650, ChemicalBookNo:CB82546919]
synonym: "NHS-PEG6-Maleimide" EXACT []
synonym: "Malamido-PEG6-NHS" EXACT []
synonym: "SM[PEG]6" EXACT []
property_value: hydrophilicPEGchain: "6" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "32.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02157
name: Maleimide-PEG8-NHS
def: "Succinimidyl-[(N-maleimidopropionamido)-octaethyleneglycol] ester." [CAS:756525-93-6, PubChem_Compound:57568672, MDL:MFCD11041144, ChemSpiderID:32055649, ChemicalBookNo:CB62546920]
synonym: "NHS-PEG8-Maleimide" EXACT []
synonym: "Malamido-PEG8-NHS" EXACT []
synonym: "SM[PEG]8" EXACT []
property_value: hydrophilicPEGchain: "8" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "39.25" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02158
name: Maleimide-PEG12-NHS
def: "Succinimidyl-[(N-maleimidopropionamido)-dodecaethyleneglycol] ester." [CAS:1426151-00-9, PubChem_Compound:51340947, MDL:MFCD11041148, ChemSpiderID:32055629, ChemicalBookNo:CB32750847]
synonym: "NHS-PEG12-Maleimide" EXACT []
synonym: "Malamido-PEG12-NHS" EXACT []
synonym: "SM[PEG]12" EXACT []
property_value: hydrophilicPEGchain: "12" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "53.4" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02159
name: Maleimide-PEG24-NHS
def: "Succinimidyl-[(N-maleimidopropionamido)-tetracosaethyleneglycol] ester." [PubChem_Compound:89408683]
synonym: "NHS-PEG24-Maleimide" EXACT []
synonym: "Malamido-PEG24-NHS" EXACT []
synonym: "SM[PEG]24" EXACT []
property_value: hydrophilicPEGchain: "24" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "95.2" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02160
name: 11-Maleimidoundecanoic Acid Sulfo-N-Succinimidyl Ester
def: "11-Maleimidoundecanoic Acid Sulfo-N-Succinimidyl Ester cross-linker." [CAS:211236-68-9, PubChem_Compound:5066232, MDL:MFCD01075057, ChemSpiderID:4243138, ChemicalBookNo:CB51025445]
synonym: "Sulfo-Kmus" EXACT []
property_value: hydrophilicPEGchain: "4" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "15.7" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02161
name: DTME
def: "Dithio-bis-maleimidoethane." [CAS:71865-37-7, PubChem_Compound:191989, MDL:MFCD01863385, ChemSpiderID:166677, ChemicalBookNo:CB3134825]
synonym: "Dithio-bis-maleimidoethane" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "13.3" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02162
name: 3-N-Maleimidobenzoic Acid N-Succinimidyl Ester
def: "3-N-Maleimidobenzoic Acid N-Succinimidyl Ester cross-linker." [CAS:58626-38-3, PubChem_Compound:93861, ChemSpiderID:84714, ChemicalBookNo:CB0342553]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02163
name: N-Succinimidyl 3-(Bromoacetamido)propionate
def: "N-Succinimidyl 3-(Bromoacetamido)propionate cross-linker." [CAS:57159-62-3, PubChem_Compound:4463814, ChemSpiderID:3662399, ChemicalBookNo:CB1123003]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "6.2" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00128 ! bromoacetyl

[Term]
id: XLMOD:02164
name: MTS-3-MTS
def: "1,3-Propanediyl bismethanethiosulfonate." [CAS:55-96-9, PubChem_Compound:571841, ChemSpiderID:497206, ChemicalBookNo:CB51175454]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02165
name: MTS-4-MTS
def: "1,4-Butanediyl bismethanethiosulfonate." [CAS:55-99-2, PubChem_Compound:241169, ChemSpiderID:210759, ChemicalBookNo:CB11175456]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02166
name: MTS-5-MTS
def: "1,5-Pentanediyl bismethanethiosulfonate." [ChemSpiderID:58967]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02167
name: MTS-6-MTS
def: "1,6-Hexanediyl bismethanethiosulfonate." [CAS:56-01-9, PubChem_Compound:3360826, ChemSpiderID:2606746, ChemicalBookNo:CB61497498]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate

[Term]
id: XLMOD:02168
name: 6-maleimidocaproic acid
def: "6-Maleimidocaproic acid cross-linker." [CAS:55750-53-3, PubChem_Compound:573683, MDL:MFCD00043140, ChemSpiderID:498795, ChemicalBookNo:CB6300928]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.4" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00138 ! carboxyl 

[Term]
id: XLMOD:02169
name: SFAD
def: "Succinimidyl(perfluoroazidobenzamido)ethyl-1,3´-dithiopropionate." [PubChem_Compound:90471066, ChemSpiderID:30798432, ChemicalBookNo:CB9178443]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "14.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00136 ! perfluoroaryl azide
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02170
name: LCABH
def: "LCABH cross-linker." [PSI:XL]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "14.6" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: has_reactive_group XLMOD:00126 ! phenyl azide
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:02171
name: NHS-LC-ASA
def: "Succinimidyl(4-azido-salicylamido) hexanoate." [PSI:XL]
synonym: "NHS-Long Chain-ASA" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "18.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00020 ! iodinatable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00125 ! hydroxyphenyl azide

[Term]
id: XLMOD:02172
name: AEDP-HCl
def: "3-([2-Aminoethyl] dithio)-propionic acid hydrochloride." [CAS:351422-31-6, ChemSpiderID:4366598, ChemicalBookNo:CB11564306]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00133 ! amine reactive group
relationship: has_reactive_group XLMOD:00138 ! carboxyl
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02173
name: AMAS
def: "N-(alpha-Maleimidoacetoxy)-succinimide ester." [CAS:55750-61-3, PubChem_Compound:3299229, ChemSpiderID:2547634, ChemicalBookNo:CB4326351]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "4.4" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02174
name: BMB
def: "1,4-Bis-Maleimidobutane." [CAS:28537-70-4, PubChem_Compound:239576, ChemSpiderID:209301, ChemicalBookNo:CB4131366]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "10.9" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02175
name: BMDB
def: "1,4-Bis-Maleimidyl-2,3-dihydroxybutane." [ChemSpiderID:4222027, ChemicalBookNo:CB9370889]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "10.2" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: is_cleavable XLMOD:00024 ! periodate cleavable

[Term]
id: XLMOD:02176
name: BMOE
def: "Bis-Maleimidoethane." [CAS:5132-30-9, PubChem_Compound:237509, MDL:MFCD00458699, ChemSpiderID:11359915, ChemicalBookNo:CB5476024]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "8.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02177
name: BMPA
def: "N-beta-Maleimidopropionic acid." [CAS:7423-55-4, PubChem_Compound:573621, ChemSpiderID:498738, ChemicalBookNo:CB1371466]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "5.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00138 ! carboxyl

[Term]
id: XLMOD:02178
name: BMPH
def: "N-(beta-Maleimidopropionic acid)hydrazide." [CAS:359436-60-5, PubChem_Compound:4401583, ChemSpiderID:3602748, ChemicalBookNo:CB0106874]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "8.1" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:02179
name: BM(PEG)2
def: "1,8-Bis-Maleimidodiethyleneglycol." [CAS:115597-84-7, PubChem_Compound:3690297, MDL:MFCD01096749, ChemSpiderID:2922525, ChemicalBookNo:CB9190751]
synonym: "BM[PEO]2" EXACT []
synonym: "maleimide-PEG2-maleimide" EXACT []
property_value: hydrophilicPEGchain: "2" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "14.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02180
name: BM(PEG)3
def: "1,8-Bis-Maleimidotriethyleneglycol." [CAS:86099-06-1, PubChem_Compound:3331999, ChemSpiderID:2579075, ChemicalBookNo:CB9190751]
synonym: "BM[PEO]3" EXACT []
synonym: "maleimide-PEG3-maleimide" EXACT []
property_value: hydrophilicPEGchain: "3" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "17.8" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02181
name: BM(PEG)4
def: "1,11-Bis-Maleimidotetraethyleneglycol." [CAS:86099-06-1, PubChem_Compound:3331999, ChemSpiderID:2579075, ChemicalBookNo:CB8506674]
synonym: "BM[PEO]4" EXACT []
synonym: "maleimide-PEG4-maleimide" EXACT []
property_value: hydrophilicPEGchain: "4" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "19.9" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02182
name: C6-SANH
def: "C6-Succinimidyl 4-hydrazinonicotinate acetone hydrazone." [CAS:937249-76-8, ChemicalBookNo:CB9456561]
comment: SANH with extended six carbon linker.
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "14.4" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00143 ! hydrazone

[Term]
id: XLMOD:02183
name: C6-4-SFB
def: "C6-Succinimidyl 4-formylbenzoate." [CAS:1005773-18-1, ChemicalBookNo:CB0456285]
comment: SFB with extended six carbon linker.
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "13.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00141 ! carbonyl

[Term]
id: XLMOD:02184
name: SBAP
def: "Succinimdyl 3-(bromoacetamido)propionate." [CAS:57159-62-3, PubChem_Compound:4463814, ChemSpiderID:3662399, ChemicalBookNo:CB1123003]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "6.2" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00128 ! bromoacetyl

[Term]
id: XLMOD:02185
name: SFB
def: "Succinimidyl 4-formylbenzoate." [CAS:60444-78-2, PubChem_Compound:4126130, ChemSpiderID:3339198, ChemicalBookNo:CB7361809]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "5.8" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00141 ! carbonyl

[Term]
id: XLMOD:02186
name: SHTH
def: "Succinimidyl 4-hydrazidoterephthalate hydrochloride." [PSI:XL]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:02187
name: Sulfo-KMUS
def: "N-(kappa-maleimidoundecanoyloxy)sulfosuccinimide ester." [CAS:220935-13-7, PubChem_Compound:5066232, ChemSpiderID:4243138, ChemicalBookNo:CB2774516]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "19.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:02188
name: THPP
def: "beta-(tris[hydroxymethyl]phosphine)propionic acid." [CAS:15931-64-3, PubChem_Compound:4095799, ChemSpiderID:3310006, ChemicalBookNo:CB2497718]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "3.03" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00138 ! carboxyl
relationship: has_reactive_group XLMOD:00139 ! hydroxymethyl phosphine

[Term]
id: XLMOD:02189
name: EMCA
def: "N-epsilon-Maleimidocaproic acid." [CAS:55750-53-3, PubChem_Compound:573683, ChemSpiderID:2006116, ChemicalBookNo:CB6300928]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.4" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00138 ! carboxyl

[Term]
id: XLMOD:02190
name: HBVS
def: "1,6-Hexane-bis-vinylsulfone." [ChemicalBookNo:CB02711432, MDL:MFCD01866933]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "14.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00140 ! vinyl sulfone

[Term]
id: XLMOD:02191
name: KMUA
def: "N-kappa-Maleimidoundecanoic acid." [CAS:57079-01-3, PubChem_Compound:4618600, ChemSpiderID:3809539, ChemicalBookNo:CB41175477]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "15.7" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00138 ! carboxyl

[Term]
id: XLMOD:02192
name: KMUH
def: "N-(kappa-Maleimidoundecanoic acid)hydrazide." [CAS:359436-62-7, PubChem_Compound:4438236, ChemSpiderID:3637842, ChemicalBookNo:CB71175478]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "19.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: is_cleavable XLMOD:00041 ! thiol cleavable

[Term]
id: XLMOD:02193
name: MPBH
def: "4-(4-N-Maleimidophenyl)butyric acid hydrazide-HCl." [PubChem_Compound:9904748, ChemSpiderID:8080402, ChemicalBookNo:CB0734136]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "17.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: is_cleavable XLMOD:00041 ! thiol cleavable

[Term]
id: XLMOD:02194
name: SANH
def: "Succinimidyl-2-(m-azido-o-nitrobenzamido)ethyl 1,3'-dithiopropionate." [ChemSpiderID:32034301, ChemicalBookNo:CB8354354]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "6.7" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00143 ! hydrazone

[Term]
id: XLMOD:02195
name: SAND-PR
def: "Sulfosuccinimidyl-2-(m-azido-o-nitrobenzamido)ethyl 1,3'-dithiopropionate." [CAS:112820-42-5, MDL:MFCD02091654, ChemSpiderID:115619, ChemicalBookNo:CB71367710]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "6.7" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00143 ! hydrazone

[Term]
id: XLMOD:02196
name: Sulfo-SAPD
def: "Sulfosuccinimidyl 2-(4-azidosalicylamido) ethyl-1,3-dithioproprioonate." [ChemicalBookNo:CB5476059]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00125 ! hydroxyphenyl azide

[Term]
id: XLMOD:02197
name: SAPD
def: "Succinimidyl 2-(4-azidosalicylamido) ethyl-1,3-dithioproprioonate." [ChemicalBookNo:CB5476059]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00125 ! hydroxyphenyl azide

[Term]
id: XLMOD:02198
name: BS(PEG)5
def: "Bis(sulfosuccinimidyl)suberate pentaethyleneglycol." [CAS:756526-03-1, PubChem_Compound:51340935, ChemSpiderID:28604877, ChemicalBookNo:CB12663893]
synonym: "NHS-PEG5-NHS" EXACT []
property_value: bridgeFormula: "C14 H22 O7" xsd:string
property_value: hydrophilicPEGchain: "5" xsd:nonNegativeInteger
property_value: monoIsotopicMass: "302.13655" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "21.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester

[Term]
id: XLMOD:02199
name: BS(PEG)9
def: "Bis(sulfosuccinimidyl)suberate nonaethyleneglycol." [CAS:1008402-79-6, PubChem_Compound:77078480, ChemSpiderID:29354490, ChemicalBookNo:CB32546994]
synonym: "NHS-PEG9-NHS" EXACT []
property_value: hydrophilicPEGchain: "9" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "35.8" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester

[Term]
id: XLMOD:02200
name: NHS-azide
def: "N-hydroxysuccinimide ester ethane azide." [PSI:XL]
synonym: "Azido-NHS ester" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "2.5" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:02201
name: NHS-PEG4-azide
def: "N-hydroxysuccinimide ester tetraoxapentadecane azide." [CAS:944251-24-5, PubChem_Compound:51340931, ChemSpiderID:28604876, ChemicalBookNo:CB72663895]
synonym: "Azido-PEG4-NHS ester" EXACT []
property_value: hydrophilicPEGchain: "4" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "18.9" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:02202
name: NHS-PEG12-azide
def: "N-hydroxysuccinimide ester dodecaoxanonatriacontane azide." [CAS:1610796-02-5, PubChem_Compound:51340930, ChemSpiderID:29354441, ChemicalBookNo:CB63062337]
synonym: "Azido-PEG12-NHS ester" EXACT []
property_value: hydrophilicPEGchain: "12" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "47.3" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:02203
name: SPDP-PEG4-NHS ester
def: "2-pyridyldithiol-tetraoxatetradecane-N-hydroxysuccinimide." [CAS:1334177-95-5, PubChem_Compound:77078429, ChemSpiderID:29354407, ChemicalBookNo:CB83163140]
synonym: "PEG4-SPDP" EXACT []
property_value: hydrophilicPEGchain: "4" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "25.7" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00109 ! pyridinyldisulfide

[Term]
id: XLMOD:02204
name: SPDP-PEG12-NHS ester
def: "2-pyridyldithiol-tetraoxaoctatriacontane-N-hydroxysuccinimide." [PubChem_Compound:51341026, ChemicalBookNo:CB53163134]
synonym: "PEG12-SPDP" EXACT []
property_value: hydrophilicPEGchain: "12" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "54.1" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00109 ! pyridinyldisulfide

[Term]
id: XLMOD:02205
name: BPM
def: "4-(N-Maleimido)benzophenone." [CAS:92944-71-3, PubChem_Compound:24897368, MDL:MFCD00079465, ChemSpiderID:129121, ChemicalBookNo:CB6293028]
synonym: "Benzophenone-4-maleimide" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide
relationship: has_reactive_group XLMOD:00119 ! benzophenone

[Term]
id: XLMOD:02206
name: TPAL
def: "1,4-Phthalaldehyde." [CAS:623-27-8, PubChem_Compound:12173, ChemSpiderID:11673, ChemicalBookNo:CB1425781]
property_value: bridgeFormula: "C8 H6" xsd:string
property_value: monoIsotopicMass: "102.04695021" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00141 ! carbonyl

[Term]
id: XLMOD:02207
name: DEB
def: "Diformyl-5-ethynylbenzene." [ChemSpiderID:26667536]
synonym: "4-Ethynylphthalaldehyde" EXACT []
property_value: bridgeFormula: "C10 H6" xsd:string
property_value: monoIsotopicMass: "126.04695021" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00141 ! carbonyl

[Term]
id: XLMOD:02208
name: DMTMM
def: "4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride." [CAS:3945-69-5, PubChem_Compound:2734059, ChemSpiderID:2015817, ChemicalBookNo:CB5695021, PMID:24938783]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00146 ! dimethylether

[Term]
id: XLMOD:02209
name: PDH
def: "Pimelic acid dihydrazide." [CAS:13043-98-6, PubChem_Compound:284646, ChemSpiderID:250842, ChemicalBookNo:CB9261011]
synonym: "Heptanedihydrazide" EXACT []
property_value: bridgeFormula: "C7 H12 N4" xsd:string
property_value: monoIsotopicMass: "152.10619642" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:02210
name: PDH-d10
def: "Deuterium labelled pimelic acid dihydrazide." [PSI:XL]
property_value: bridgeFormula: "C7 D10 H2 N4" xsd:string
property_value: doubletDeltaMass: "10.06276744" xsd:double
property_value: monoIsotopicMass: "162.16896386" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02211
name: ABAS
def: "Azidobenzoic acid succinimide." [CAS:53053-08-0, PubChem_Compound:122153, ChemSpiderID:108951, ChemicalBookNo:CB5187007, PMID:25192908]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:02212
name: ABAS-13C6
def: "13C labelled azidobenzoic acid succinimide." [PMID:25192908]
property_value: doubletDeltaMass: "6.02016" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide
relationship: is_labelled XLMOD:00036 ! 13C labelled

[Term]
id: XLMOD:02213
name: CBS
def: "Carboxy-benzophenone-succinimide." [PMID:25192908]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00119 ! benzophenone

[Term]
id: XLMOD:02214
name: CBS-13C6
def: "13C labelled carboxy-benzophenone-succinimide." [PMID:25192908]
property_value: doubletDeltaMass: "6.02016" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "7.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00119 ! benzophenone
relationship: is_labelled XLMOD:00036 ! 13C labelled

[Term]
id: XLMOD:02215
name: SDA-13C5
def: "13C labelled succinimidyl-ester diazirine." [PMID:25192908]
property_value: bridgeFormula: "13C5 H6 O1" xsd:string
property_value: doubletDeltaMass: "5.0168" xsd:double
property_value: monoIsotopicMass: "87.05866484" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "5.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00103 ! diazirine
relationship: is_labelled XLMOD:00036 ! 13C labelled

[Term]
id: XLMOD:02216
name: DMDSSO
def: "Dimethyl disuccinimidyl sulfoxide." [PMID:24471733, PMID:27417384]
synonym: "DMDSSO-d0" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00067 ! CID cleavable C-S bond

[Term]
id: XLMOD:02217
name: DMDSSO-d10
def: "Deuterium labelled dimethyl disuccinimidyl sulfoxide." [PMID:24471733]
property_value: doubletDeltaMass: "10.06276744" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_cleavable XLMOD:00067 ! CID cleavable C-S bond

[Term]
id: XLMOD:02218
name: ICATXL1
def: "N-biotinyl-N'-[3,5-Bis-(N-succinimidyloxycarbonyl-methoxy)-benzoyl]-ethane-1,2-diamine." [PMID:16895390]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:02219
name: ICATXL2
def: "S-S-biotinyl-N'-[3,5-Bis-(N-succinimidyloxycarbonyl-methoxy)-benzoyl]-ethane-1,2-diamine." [PMID:16895390]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:02220
name: SSTN
def: "Succinic acid succinimidyl ester 5-thioyloxy-2-nitrobenzyl ester." [PMID:15366956]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00148 ! nitrobenzylester

[Term]
id: XLMOD:02221
name: SCNE
def: "Di 6-(3-succinimidyl carbonyloxymethyl-4-nitro-phenoxy)-hexanoic acid disulfide diethanol ester." [PMID:22432929]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond
relationship: is_cleavable XLMOD:00147 ! photocleavable

[Term]
id: XLMOD:02222
name: azide-A-DSBSO
def: "Azide-tagged acid-cleavable disuccinimidyl-bissulfoxide." [PMID:25823605, PMID:27417384, PMID:25253489]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00055 ! azide
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00018 ! cleavable by MS2 labile bond
relationship: is_cleavable XLMOD:00066 ! acid cleavable
relationship: is_cleavable XLMOD:00067 ! CID cleavable C-S bond

[Term]
id: XLMOD:02223
name: alkyne-A-DSBSO
def: "Alkyne-tagged acid-cleavable disuccinimidyl-bissulfoxide." [PMID:25823605, PMID:29537042]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00053 ! alkyne
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00066 ! acid cleavable
relationship: is_cleavable XLMOD:00067 ! CID cleavable C-S bond

[Term]
id: XLMOD:02224
name: IML 3
def: "Identical mass linker 3." [PMID:26269432]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02225
name: SuVP
def: "Disuccinimidyl-succinamyl-valyl-proline." [PMID:26091612, PMID:20560670]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.2" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02226
name: DHSO
def: "Dihydrazide sulfoxide." [PMID:27417384]
synonym: "3,3'-sulfinyldi(propanehydrazide)" EXACT []
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "12.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: is_cleavable XLMOD:00067 ! CID cleavable C-S bond

[Term]
id: XLMOD:02227
name: PL
def: "Photo-cleavable Leiker." [PMID:26952210, PMID:27734140]
property_value: CID_Fragment: "122.06" xsd:double
property_value: monoIsotopicMass: "316.14" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00147 ! photocleavable

[Term]
id: XLMOD:02228
name: PEG-PL
def: "Polyethylene glycol photo-cleavable Leiker." [PMID:26952210]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00147 ! photocleavable

[Term]
id: XLMOD:02229
name: Sulfo-PL
def: "Sulfo-photo-cleavable Leiker." [PMID:26952210]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00147 ! photocleavable

[Term]
id: XLMOD:02230
name: bAL1
def: "Biotinylated azo-Leiker 1 with an azobenzene-based chemical cleavage site." [PMID:26952210]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.3" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:02231
name: bAL2
def: "Biotinylated azo-Leiker 2 with an azobenzene-based chemical cleavage site." [PMID:26952210]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.3" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00017 ! chemically cleavable

[Term]
id: XLMOD:02232
name: bAL2-d6
def: "Deuterium labelled biotinylated azo-Leiker 2 with an azobenzene-based chemical cleavage site." [PMID:26952210]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.3" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_cleavable XLMOD:00017 ! chemically cleavable
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:02233
name: BS3-18O2
def: "18O labelled (bis(sulfosuccinimidyl) 2,2,7,7-suberate)." [PMID:14592499]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "11.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: is_labelled XLMOD:00069 !  18O labelled

[Term]
id: XLMOD:02234
name: PIR-I
def: "Protein Interaction Reporter-I." [PMID:17269728]
property_value: bridgeFormula: "C6 H10 O2 N1" xsd:string
property_value: hydrophilicPEGchain: "3" xsd:nonNegativeInteger
property_value: monoIsotopicMass: "128.0712" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: reporterMass: "555.2481" xsd:double
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02235
name: PIR-II
def: "Protein Interaction Reporter-II." [PMID:17269728]
property_value: bridgeFormula: "C4 H6 O2 N1" xsd:string
property_value: hydrophilicPEGchain: "3" xsd:nonNegativeInteger
property_value: monoIsotopicMass: "100.0399" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: reporterMass: "1324.5937" xsd:double
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02236
name: PIR-III
def: "Protein Interaction Reporter-III." [PMID:17269728]
property_value: bridgeFormula: "C4 H6 O2 N1" xsd:string
property_value: hydrophilicPEGchain: "3" xsd:nonNegativeInteger
property_value: monoIsotopicMass: "100.0399" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: reporterMass: "1604.6996" xsd:double
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00034 ! photo cleavable
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02237
name: PIR
def: "Protein Interaction Reporter." [PMID:15623310]
property_value: CID_Fragment: "711.4" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02238
name: pcPIR
def: "Photo-cleavable Protein Interaction Reporter." [PMID:20373789]
property_value: CID_Fragment: "711.4" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "40.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00034 ! photo cleavable
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02239
name: PEG5-Biotin-Dimer
def: "PEG5-Biotin-Dimer for crosslinking avidin molecules." [PSI:XL]
property_value: hydrophilicPEGchain: "5" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "43.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00118 ! tetrafluorophenyl azide

[Term]
id: XLMOD:02240
name: Azido-PEG3-NHS ester
def: "1-[(3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoyl)oxy]-2,5-pyrrolidinedione." [CAS:1245718-89-1, PubChem_Compound:77078451, ChemSpiderID:29354443, ChemicalBookNo:CB83062351]
synonym: "NHS-PEG3-azide" EXACT []
property_value: hydrophilicPEGchain: "3" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:02241
name: Azido-PEG5-NHS ester
def: "1-[(1-Azido-18-oxo-3,6,9,12,15-pentaoxaoctadecan-18-yl)oxy]-2,5-pyrrolidinedione." [CAS:1433996-86-1, PubChem_Compound:77078433, ChemSpiderID:29354411, ChemicalBookNo:CB23062364]
synonym: "NHS-PEG5-azide" EXACT []
property_value: hydrophilicPEGchain: "5" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:02242
name: Azido-PEG6-NHS ester
def: "1-[(1-Azido-21-oxo-3,6,9,12,15,18-hexaoxahenicosan-21-yl)oxy]-2,5-pyrrolidinedione." [CAS:2055014-64-5, PubChem_Compound:77078479, ChemSpiderID:29354488, ChemicalBookNo:CB43162882]
synonym: "NHS-PEG6-azide" EXACT []
property_value: hydrophilicPEGchain: "6" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:02243
name: Azido-PEG8-NHS ester
def: "1-[(1-Azido-27-oxo-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-yl)oxy]-2,5-pyrrolidinedione." [CAS:1204834-00-3, PubChem_Compound:51340932, ChemSpiderID:29354442, ChemicalBookNo:CB53062370]
synonym: "NHS-PEG8-azide" EXACT []
property_value: hydrophilicPEGchain: "8" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:02244
name: Azido-PEG10-NHS ester
def: "Azido-PEG10-NHS ester." [PubChem_Compound:134159750]
synonym: "NHS-PEG10-azide" EXACT []
property_value: hydrophilicPEGchain: "10" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:02245
name: Azido-PEG16-NHS ester
def: "Azido-PEG16-NHS ester." [PubChem_Compound:126480441]
synonym: "NHS-PEG16-azide" EXACT []
property_value: hydrophilicPEGchain: "16" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:02246
name: Azido-PEG24-NHS ester
def: "Azido-PEG24-NHS ester." [PubChem_Compound:126480440]
synonym: "NHS-PEG24-azide" EXACT []
property_value: hydrophilicPEGchain: "24" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:02247
name: SPDP-PEG24-NHS ester
def: "2,5-Dioxocyclopentyl 77-oxo-79-(2-pyridinyldisulfanyl)-4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73-tetracosaoxa-76-azanonaheptacontan-1-oate." [PubChem_Compound:77078309, ChemSpiderID:32055782, ChemicalBookNo:CB13163136]
synonym: "PEG24-SPDP" EXACT []
property_value: hydrophilicPEGchain: "24" xsd:nonNegativeInteger
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00109 ! pyridinyldisulfide

[Term]
id: XLMOD:02248
name: S-Methyl 5,5'-thiodipentanoylhydroxysuccinimide
def: "S-Methyl 5,5'-thiodipentanoylhydroxysuccinimide cross-linker." [PMID:19551991]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02249
name: Sulfo-SBP
def: "4-(N-Sulfosuccinimidylcarboxy)benzophenone." [CAS:91990-88-4, PMID:28430416]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: specificities: "(K,S,T,Y,Protein N-term)" xsd:string
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00119 ! benzophenone
relationship: is_activatable XLMOD:00149 ! photoactivatable

[Term]
id: XLMOD:02250
name: CBSS
def: "Carboxybenzophenonesulfosuccinimide." [PMID:31045356]
property_value: reactionSites: "2" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00119 ! benzophenone

[Term]
id: XLMOD:02251
name: MC4
def: "1,4-bis(4-((2,5-dioxopyrrolidin-1-yl)oxy)-4-oxobutyl)-1,4-diazabicyclo[2.2.2]octane-1,4-diium." [PMID:31045356, PMID:29537042]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "13.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02252
name: PAC4
def: "PAC4 cross-linker." [PMID:29537042]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "13.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02253
name: cliXLink
def: "cliXLink cross-linker." [PMID:31593346]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "9.2" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00053 ! alkyne
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:02254
name: ARGO1
def: "R-R aromatic glyoxal cross-linker 1." [PMID:31477730]
property_value: hydrophilicPEGchain: "1" xsd:nonNegativeInteger
property_value: monoIsotopicMass: "326.079" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "29.4" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00142 ! phenylglyoxal

[Term]
id: XLMOD:02255
name: ARGO2
def: "R-R aromatic glyoxal cross-linker 2." [PMID:31477730]
property_value: hydrophilicPEGchain: "2" xsd:nonNegativeInteger
property_value: monoIsotopicMass: "370.105" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "33.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00142 ! phenylglyoxal

[Term]
id: XLMOD:02256
name: ARGO3
def: "R-R aromatic glyoxal cross-linker 3." [PMID:31477730]
property_value: hydrophilicPEGchain: "3" xsd:nonNegativeInteger
property_value: monoIsotopicMass: "414.131" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "37.7" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00142 ! phenylglyoxal

[Term]
id: XLMOD:02257
name: KARGO
def: "K-R aromatic glyoxal cross-linker." [PMID:31477730]
property_value: monoIsotopicMass: "352.095" xsd:double
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "54.1" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00142 ! phenylglyoxal
relationship: has_reactive_group XLMOD:00171 ! Ortho-phthalaldehyde

[Term]
id: XLMOD:02258
name: PhoX
def: "PhoX cross-linker." [PMID:31477730]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: spacerLength: "5.0-20.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00173 ! phosphonic acid
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:03001
name: CBDPS
def: "Cyanurbiotindipropionylsuccinimide." [PMID:20622150]
property_value: bridgeFormula: "C19 H23 N7 O4 S3" xsd:string
property_value: monoIsotopicMass: "509.09682" xsd:double
property_value: reactionSites: "3" xsd:nonNegativeInteger
property_value: spacerLength: "14.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_property XLMOD:00014 ! hydrophilic
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_cleavable XLMOD:00035 ! CID cleavable

[Term]
id: XLMOD:03002
name: Sulfo-SBED
def: "Sulfo-SBED cross-linker." [PubChem_Compound:101089650, ChemicalBookNo:CB2771737, PMID:15144972, PMID:16246579, PMID:15144972]
synonym: "Sulfo-N-hydroxysuccinimidyl-2-(6-[biotinamido]-2-(p-azido benzamido)-hexanoamido) ethyl-1,3'-dithioproprionate" EXACT []
property_value: monoIsotopicMass: "634.207" xsd:double
property_value: reactionSites: "3" xsd:nonNegativeInteger
property_value: spacerLength: "9.1" xsd:float
property_value: spacerLength: "13.7" xsd:float
property_value: spacerLength: "19.1" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00102 ! Sulfo NHS ester
relationship: has_reactive_group XLMOD:00126 ! phenyl azide
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:03003
name: Mts-Atf-Biotin
def: "2-[N2-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-N6-(6-biotinamidocaproyl)-L-lysinyl]ethylmethanethiosulfate." [CAS:1356383-18-0, PubChem_Compound:57370043, ChemSpiderID:48058836, ChemicalBookNo:CB4994943]
synonym: "tetrafluorobenzoyl-biotinamidocaproyl-methanethiosulfonate" EXACT []
property_value: reactionSites: "3" xsd:nonNegativeInteger
property_value: spacerLength: "11.1" xsd:float
property_value: spacerLength: "29.3" xsd:float
property_value: spacerLength: "30.7" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00118 ! tetrafluorophenyl azide
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate 
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:03004
name: Mts-Atf-LC-Biotin
def: "2-{N2-[N6-(4-Azido-2,3,5,6-tetrafluorobenzoyl)-N6-(6-biotinamidocaproyl)-L-lysinyl]}ethylmethanethiosulfate." [PSI:XL]
synonym: "Mts-Atf-Long Chain-Biotin" EXACT []
property_value: reactionSites: "3" xsd:nonNegativeInteger
property_value: spacerLength: "11.1" xsd:float
property_value: spacerLength: "29.3" xsd:float
property_value: spacerLength: "30.7" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00118 ! tetrafluorophenyl azide
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate 

[Term]
id: XLMOD:03005
name: TSAT
def: "Tris-succinimidyl aminotriacetate." [CAS:401514-72-5, PubChem_Compound:4150925, MDL:MFCD02258953, ChemSpiderID:3363127, ChemicalBookNo:CB8454500]
property_value: reactionSites: "3" xsd:nonNegativeInteger
property_value: spacerLength: "4.2" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:03006
name: SBED
def: "SBED cross-linker." [PSI:XL]
synonym: "N-hydroxysuccinimidyl-2-(6-[biotinamido]-2-(p-azido benzamido)-hexanoamido) ethyl-1,3'-dithioproprionate" EXACT []
property_value: reactionSites: "3" xsd:nonNegativeInteger
property_value: spacerLength: "9.1" xsd:float
property_value: spacerLength: "13.7" xsd:float
property_value: spacerLength: "19.1" xsd:float
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00126 ! phenyl azide
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:03007
name: TMEA
def: "Tris-(2-maleimidoethyl)amine." [CAS:139112-38-2, PubChem_Compound:9977418, MDL:MFCD01868689, ChemSpiderID:8153010, ChemicalBookNo:CB8193391]
property_value: reactionSites: "3" xsd:nonNegativeInteger
property_value: spacerLength: "10.3" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:03008
name: TRICEPS
def: "TRICEPS cross-linker." [PubChem_Compound:72663594, PMID:23051814]
property_value: reactionSites: "3" xsd:nonNegativeInteger
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00143 ! hydrazone
relationship: is_cleavable XLMOD:00024 ! periodate cleavable

[Term]
id: XLMOD:03009
name: NNP9
def: "NNP9 cross-linker." [PMID:25522193]
property_value: bridgeFormula: "C7 D10 H2 N4" xsd:string
property_value: monoIsotopicMass: "314.1127" xsd:double
property_value: reactionSites: "3" xsd:nonNegativeInteger
property_value: spacerLength: "10.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:03010
name: TATA
def: "2,4,6-triazido-1,3,5-triazine." [CAS:5637-83-2, PubChem_Compound:21857, ChemSpiderID:20543, ChemicalBookNo:CB82442831, PMID:26931439]
synonym: "Cyanuric triazide" EXACT []
property_value: monoIsotopicMass: "200.05" xsd:double
property_value: reactionSites: "3" xsd:nonNegativeInteger
property_value: spacerLength: "5.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00055 ! azide

[Term]
id: XLMOD:03011
name: TATA-13C6
def: "13C labelled 2,4,6-triazido-1,3,5-triazine." [PMID:26931439]
property_value: doubletDeltaMass: "6.02016" xsd:double
property_value: monoIsotopicMass: "206.07016" xsd:double
property_value: reactionSites: "3" xsd:nonNegativeInteger
property_value: spacerLength: "5.0" xsd:float
is_a: XLMOD:00005 ! homofunctional cross-linker
relationship: has_reactive_group XLMOD:00055 ! azide
relationship: is_labelled XLMOD:00036 ! 13C labelled

[Term]
id: XLMOD:03012
name: MRN
def: "MRN cross-linker." [PMID:18303833]
property_value: reactionSites: "3" xsd:nonNegativeInteger
property_value: spacerLength: "6.4" xsd:float
property_value: spacerLength: "11.4" xsd:float
property_value: spacerLength: "40.0" xsd:float
is_a: XLMOD:00006 ! heterofunctional cross-linker
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00101 ! NHS ester

[Term]
id: XLMOD:03013
name: Mts-Atf-Biotin-LC
def: "Long chain Mts-Atf-Biotin." [PSI:XL]
property_value: reactionSites: "3" xsd:nonNegativeInteger
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00118 ! tetrafluorophenyl azide
relationship: has_reactive_group XLMOD:00121 ! methanethiosulfonate 
relationship: is_cleavable XLMOD:00023 ! cleavable S-S bond

[Term]
id: XLMOD:03014
name: DADPS linker
def: "Linker containing a dialkoxydiphenylsilane group." [PMID:31430117]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: specificities: "(C,U)" xsd:string
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00055 ! azide
is_a: XLMOD:00099 ! formic acid cleavable

[Term]
id: XLMOD:03015
name: AZO linker
def: "Linker containing a azobenzene group." [PMID:31430117]
property_value: reactionSites: "2" xsd:nonNegativeInteger
property_value: specificities: "(C,U)" xsd:string
is_a: XLMOD:00003 ! label transfer reagent
relationship: has_handle XLMOD:00051 ! biotin
relationship: has_reactive_group XLMOD:00055 ! azide
is_a: XLMOD:00169 ! sodium dithionite cleavable

[Term]
id: XLMOD:06000
name: derivatization entity
def: "Entity relevant to the domain of derivatization in chromatography." [PSI:XL]
relationship: part_of XLMOD:00000 ! Proteomics Standards Initiative cross-linking and derivatization controlled vocabulary

[Term]
id: XLMOD:06001
name: GCMS derivatization reagent
def: "Chemical reagent, which transforms a polar group in a molecule into a non-polar group in order to make the molecule volatile and analyzable by GC-MS." [PSI:XL]
is_a: XLMOD:06000 ! derivatization entity

[Term]
id: XLMOD:06002
name: alkylation reagent
def: "Derivatization reagent replacing an active hydrogen by an aliphatic or aliphatic-aromatic group." [PSI:XL]
is_a: XLMOD:06001 ! GCMS derivatization reagent

[Term]
id: XLMOD:06003
name: silylation reagent
def: "Silylation reagent replacing an active hydrogen by a silyl group." [PSI:XL]
is_a: XLMOD:06001 ! GCMS derivatization reagent

[Term]
id: XLMOD:06004
name: acylation reagent
def: "Acylation reagent replacing an active hydrogen by a acyl (R-C=O-) group." [PSI:XL]
is_a: XLMOD:06001 ! GCMS derivatization reagent

[Term]
id: XLMOD:06005
name: fluorinated anhydride reagent
def: "Fluorinated anhydride derivatization reagent." [PSI:XL]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:06006
name: fluoracylimidazole reagent
def: "Fluoracylimidazole derivatization reagent." [PSI:XL]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:06008
name: halomethylsilyl reagent
def: "Halogenation reagent which can produce both silylated and halogenated derivatives." [PSI:XL]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:06009
name: chiral derivatization reagent
def: "Chiral derivatization reagent with an enatiomerically pure chiral derivatizing agent to form two diastereomeric derivatives that can be separated by gas chromatography." [PSI:XL]
is_a: XLMOD:06001 ! GCMS derivatization reagent

[Term]
id: XLMOD:06010
name: LCMS derivatization reagent
def: "Chemical reagent, which transforms an analyte so that its stability, separation, extraction, ionization efficiency and MS2 detectability are improved in LC-MS analysis." [PSI:XL]
is_a: XLMOD:06000 ! derivatization entity

[Term]
id: XLMOD:06011
name: dialkylacetal
def: "Dialkylacetal reagent." [PSI:XL]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:06012
name: diazoalkal
def: "Diazoalkal reagent." [PSI:XL]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:06013
name: TMS reagent
def: "Trimethylsilyl (TMS) reagent replacing an active hydrogen by a silyl group." [PSI:XL]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:06014
name: DMS reagent
def: "Dimethylsilyl (DMS) reagent replacing an active hydrogen by a silyl group." [PSI:XL]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:06015
name: TFA reagent
def: "Trifluoroacetyl (TFA) reagent replacing an active hydrogen by a silyl group." [PSI:XL]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:06016
name: boron trifluoride reagent
def: "Boron trifluoride reagent." [PSI:XL]
is_a: XLMOD:06002 ! alkylation reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:06017
name: N,N-Dimethylformamidedialkyl acetal
def: "N,N-Dimethylformamidedialkyl acetal." [PSI:XL]
is_a: XLMOD:06002 ! alkylation reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:06018
name: chloroformate reagent
def: "Chloroformate reagent." [PSI:XL]
is_a: XLMOD:06002 ! alkylation reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00163 ! chloroformate reactive group
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:06019
name: trialkyloxonium reagent
def: "Trialkyloxonium reagent." [PSI:XL]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:06020
name: arylation reagent
def: "Derivatization reagent replacing an active hydrogen by an aliphatic-aromatic group, e.g. a -phenyl, -tolyl, -xylyl, -naphthy, -benzyl group." [PSI:XL]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:06100
name: chromophore
def: "A chromophore group attached to a derivatization reagent for enhanced UB- or VIS-detectability." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06000 ! derivatization entity

[Term]
id: XLMOD:06101
name: fluorophore
def: "A fluorophore group attached to a derivatization reagent for enhanced fluorescence or chemiluminescence detectability." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06000 ! derivatization entity

[Term]
id: XLMOD:06102
name: electrophore
def: "An electrophore group attached to a derivatization reagent for enhanced electrochemical detectability." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06000 ! derivatization entity

[Term]
id: XLMOD:06103
name: 4-nitrophenyl
def: "4-Nitrophenyl fluorophore." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06101 ! fluorophore
property_value: maxAbsorption: "265 nm" xsd:string

[Term]
id: XLMOD:06104
name: 2,4-dinitrophenyl
def: "2,4-Dinitrophenyl fluorophore." [PSI:XL]
is_a: XLMOD:06101 ! fluorophore

[Term]
id: XLMOD:06105
name: 3,5-dinitrobenzyl
def: "3,5-Dinitrobenzyl fluorophore." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06101 ! fluorophore

[Term]
id: XLMOD:06106
name: 4-chlorobenzoate
def: "4-Chlorobenzoatel fluorophore." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06101 ! fluorophore
property_value: maxAbsorption: "236 nm" xsd:string

[Term]
id: XLMOD:06107
name: 4-nitrobenzoate
def: "4-Nitrobenzoatel fluorophore." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06101 ! fluorophore
property_value: maxAbsorption: "254 nm" xsd:string

[Term]
id: XLMOD:06108
name: toluoyl
def: "Toluoyll fluorophore." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06101 ! fluorophore
property_value: maxAbsorption: "236 nm" xsd:string

[Term]
id: XLMOD:06109
name: anisyl
def: "Anisyl fluorophore." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06101 ! fluorophore
property_value: maxAbsorption: "262 nm" xsd:string

[Term]
id: XLMOD:06110
name: phenacyl
def: "Phenacyl fluorophore." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06101 ! fluorophore
property_value: maxAbsorption: "250 nm" xsd:string

[Term]
id: XLMOD:06111
name: 4-bromophenacyl
def: "4-Bromophenacyl fluorophore." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06101 ! fluorophore
property_value: maxAbsorption: "260 nm" xsd:string

[Term]
id: XLMOD:06112
name: 2-naphthacyl
def: "2-Naphthacyl fluorophore." [DOI:10.1016/B978-0-12-415806-1.00002-4]
is_a: XLMOD:06101 ! fluorophore
property_value: maxAbsorption: "248 nm" xsd:string

[Term]
id: XLMOD:06500
name: secondary amine reactive
def: "Indicates that a reactive group is reactive with secondary amino (=NH) groups." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06501
name: active hydrogen reactive
def: "Indicates that a derivatization reagent is reactive with active hydrogens like e.g. from -SH, -OH, -NH, -COOH groups." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06502
name: amide reactive
def: "Indicates that a derivatization reagent is reactive with amides." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06503
name: amino acid reactive
def: "Indicates that a derivatization reagent is reactive with amino acids." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06504
name: nitrosamine reactive
def: "Indicates that a derivatization reagent is reactive with nitrosamines." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06505
name: sulfonamide reactive
def: "Indicates that a derivatization reagent is reactive with sulfonamides." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06506
name: carbohydrate reactive
def: "Indicates that a derivatization reagent is reactive with carbohydrates and sugars." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06507
name: catecholamine reactive
def: "Indicates that a derivatization reagent is reactive with catecholamines." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06508
name: sulfide reactive
def: "Indicates that a derivatization reagent is reactive with sulfides." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06509
name: phenol reactive
def: "Indicates that a derivatization reagent is reactive with phenols." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06510
name: ketone reactive
def: "Indicates that a derivatization reagent is reactive with ketones." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06511
name: biphosphonate drug reactive
def: "Indicates that a derivatization reagent is reactive with biphosphonate drugs." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06512
name: steroid reactive
def: "Indicates that a derivatization reagent is reactive with steroids." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06513
name: thiol reactive
def: "Indicates that a derivatization reagent is reactive with thiols." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06514
name: Vitamin D metabolite reactive
def: "Indicates that a derivatization reagent is reactive with vitamin D metabolites." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06515
name: nucleoside reactive
def: "Indicates that a derivatization reagent is reactive with nucleosides." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06516
name: cholesterol reactive
def: "Indicates that a derivatization reagent is reactive with cholesterols." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06517
name: histamine reactive
def: "Indicates that a derivatization reagent is reactive with histamines." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06518
name: glycan reactive
def: "Indicates that a derivatization reagent is reactive with glycans." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06519
name: alpha-keto acid reactive
def: "Indicates that a derivatization reagent is reactive with alpha-keto-acids." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06520
name: citric acid reactive
def: "Indicates that a derivatization reagent is reactive with citric acid." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06521
name: phophate reactive
def: "Indicates that a derivatization reagent is reactive with phosphate." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06522
name: perfluorinated carboxylic acid reactive
def: "Indicates that a derivatization reagent is reactive with perfluorinated carboxylic acids." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06523
name: sialic acid reactive
def: "Indicates that a derivatization reagent is reactive with sialic acid." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:06524
name: bile acid reactive
def: "Indicates that a derivatization reagent is reactive with bile acids." [PSI:XL]
is_a: XLMOD:00027 ! chemically reactive

[Term]
id: XLMOD:07000
name: dimethylformamide
def: "Dimethylformamide." [CAS:68-12-2, PubChem_Compound:6228, MDL:MFCD00003284, ChemSpiderID:5993, ChemicalBookNo:CB2854115, DOI:10.5772/33098]
synonym: "DMF" EXACT []
is_a: XLMOD:06011 ! dialkylacetal
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06502 ! amide reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06504 ! nitrosamine reactive

[Term]
id: XLMOD:07001
name: diazomethane
def: "Diazomethane." [CAS:334-88-3, PubChem_Compound:9550, ChemSpiderID:9176, ChemicalBookNo:CB4852342, DOI:10.5772/33098]
is_a: XLMOD:06012 ! diazoalkal
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:06511 ! biphosphonate drug reactive

[Term]
id: XLMOD:07002
name: pentafluorobenzyl bromide
def: "Pentafluorobenzyl bromide." [CAS:1765-40-8, PubChem_Compound:74484, MDL:MFCD00000299, ChemSpiderID:67069, ChemicalBookNo:CB9238273, DOI:10.5772/33098, PMID:22191594]
synonym: "PFBBr" EXACT []
is_a: XLMOD:06020 ! arylation reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00168 ! benzyl bromide reactive group
relationship: is_reactive_with XLMOD:06504 ! nitrosamine reactive
relationship: is_reactive_with XLMOD:06505 ! sulfonamide reactive

[Term]
id: XLMOD:07003
name: pentafluorobenzylhydroxylaminehydrochloride
def: "Pentafluorobenzylhydroxylaminehydrochloride." [CAS:57981-02-9, PubChem_Compound:129670358, Beilstein:4031190, MDL:MFCD00012953, ChemicalBookNo:CB8307815, DOI:10.5772/33098]
synonym: "PFBHA" EXACT []
is_a: XLMOD:06020 ! arylation reagent
relationship: is_reactive_with XLMOD:00063 ! carbonyl reactive

[Term]
id: XLMOD:07004
name: benzylbromide
def: "Benzylbromide." [CAS:100-39-0, PubChem_Compound:7498, ChemSpiderID:13851576, ChemicalBookNo:CB6761035, DOI:10.5772/33098]
synonym: "BnBr" EXACT []
is_a: XLMOD:06020 ! arylation reagent
relationship: has_reactive_group XLMOD:00168 ! benzyl bromide reactive group

[Term]
id: XLMOD:07005
name: tetrabutylammoniumhydroxide
def: "Tetrabutylammoniumhydroxide." [CAS:2052-49-5, PubChem_Compound:2723671, MDL:MFCD00009425, ChemSpiderID:13851576, ChemicalBookNo:CB6371870, DOI:10.5772/33098]
synonym: "TBH" EXACT []
is_a: XLMOD:06002 ! alkylation reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:07006
name: boron trifluoride
def: "Boron trifluoride derivatization reagent." [CAS:7637-07-2, MDL:MFCD00011316, ChemSpiderID:6116, ChemicalBookNo:CB3238105, DOI:10.5772/33098]
synonym: "BF3" EXACT []
is_a: XLMOD:06016 ! boron trifluoride reagent

[Term]
id: XLMOD:07007
name: bis(trimethylsilyl)acetamide
def: "Bis(trimethylsilyl)acetamide." [CAS:10416-59-8, PubChem_Compound:6913588, Beilstein:1306669, MDL:MFCD00008270, ChemSpiderID:4523073, ChemicalBookNo:CB7366985, DOI:10.5772/33098]
synonym: "BSA" EXACT []
synonym: "N,O-Bis(trimethylsilyl)acetamide" EXACT []
is_a: XLMOD:06013 ! TMS reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06502 ! amide reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:07008
name: bis(trimethylsilyl)trifluoroacetamide
def: "Bis(trimethylsilyl)trifluoroacetamide." [CAS:25561-30-2, PubChem_Compound:94358, ChemSpiderID:58770, ChemicalBookNo:CB5464744, DOI:10.5772/33098]
synonym: "BSTFA" EXACT []
is_a: XLMOD:06013 ! TMS reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06504 ! nitrosamine reactive

[Term]
id: XLMOD:07009
name: N-methyl-trimethylsilyltrifluoroacetamide
def: "N-methyl-trimethylsilyltrifluoroacetamide." [CAS:24589-78-4, PubChem_Compound:32510, Beilstein:1941550, MDL:MFCD00000411, ChemSpiderID:30134, ChemicalBookNo:CB0161574, DOI:10.5772/33098, PMID:26478271]
synonym: "MSTFA" EXACT []
is_a: XLMOD:06013 ! TMS reagent
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:07010
name: hexamethyldisilazane
def: "Hexamethyldisilazane." [CAS:999-97-3, PubChem_Compound:13838, ChemSpiderID:13238, ChemicalBookNo:CB9105784, DOI:10.5772/33098]
synonym: "HMDS" EXACT []
is_a: XLMOD:06003 ! silylation reagent
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06506 ! carbohydrate reactive

[Term]
id: XLMOD:07011
name: trimethylchlorosilane
def: "Trimethylchlorosilane." [CAS:75-77-4, PubChem_Compound:6397, Beilstein:1209232, MDL:MFCD00000502, ChemSpiderID:6157, ChemicalBookNo:CB4375627, PMID:19525080, DOI:10.5772/33098]
synonym: "TMCS" EXACT []
synonym: "CMTS" EXACT []
synonym: "Chlorotrimethylsilane" EXACT []
is_a: XLMOD:06013 ! TMS reagent
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06506 ! carbohydrate reactive

[Term]
id: XLMOD:07012
name: trimethylsilylimidazole
def: "Trimethylsilylimidazole." [CAS:18156-74-6, PubChem_Compound:28925, Beilstein:606148, MDL:MFCD00005280, ChemSpiderID:26905, ChemicalBookNo:CB5483743, DOI:10.5772/33098, PMID:26478271]
synonym: "TMSI" EXACT []
synonym: "TMSIM" EXACT []
synonym: "1-(Trimethylsilyl)imidazole" EXACT []
is_a: XLMOD:06013 ! TMS reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06506 ! carbohydrate reactive
relationship: is_reactive_with XLMOD:06507 ! catecholamine reactive
relationship: is_reactive_with XLMOD:06508 ! sulfide reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:07013
name: trimethylsilyldiethylamine
def: "Trimethylsilyldiethylamine." [CAS:996-50-9, PubChem_Compound:70454, ChemSpiderID:63633, ChemicalBookNo:CB3771284, DOI:10.5772/33098]
synonym: "TMS-DEA" EXACT []
is_a: XLMOD:06013 ! TMS reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:07014
name: N-methyl-N-t-butyldimethylsilyltrifluoroacetamide
def: "N-methyl-N-t-butyldimethylsilyltrifluoroacetamide." [CAS:77377-52-7, PubChem_Compound:2724275, Beilstein:3606546, MDL:MFCD00009671, ChemSpiderID:2006425, ChemicalBookNo:CB7707814, DOI:10.5772/33098, PMID:26478271]
synonym: "MTBSTFA" EXACT []
synonym: "1,3-Dimethyl-1,1,3,3-tetraphenyldisilazane" EXACT []
is_a: XLMOD:06014 ! DMS reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:07015
name: trifluoroacetoic anhydride
def: "Trifluoroacetoic anhydride." [CAS:407-25-0, PubChem_Compound:9845, DOI:10.5772/33098]
synonym: "TFAA" EXACT []
is_a: XLMOD:06005 ! fluorinated anhydride reagent
is_a: XLMOD:06015 ! TFA reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive

[Term]
id: XLMOD:07016
name: pentafluoropropionic anhydride
def: "Pentafluoropropionic anhydride." [CAS:356-42-3, PubChem_Compound:67742, Beilstein:1806446, MDL:MFCD00000429, ChemicalBookNo:CB2749284, DOI:10.5772/33098]
synonym: "PFPA" EXACT []
is_a: XLMOD:06005 ! fluorinated anhydride reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06504 ! nitrosamine reactive
relationship: is_reactive_with XLMOD:06507 ! catecholamine reactive

[Term]
id: XLMOD:07017
name: heptafluorobutyric anhydride
def: "Heptafluorobutyric anhydride." [CAS:336-59-4, PubChem_Compound:67643, Beilstein:856036, MDL:MFCD00000432, ChemSpiderID:60962, ChemicalBookNo:CB5217287, DOI:10.5772/33098, PMID:26478271]
synonym: "HFBA" EXACT []
is_a: XLMOD:06005 ! fluorinated anhydride reagent
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06504 ! nitrosamine reactive
relationship: is_reactive_with XLMOD:06505 ! sulfonamide reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:07018
name: trifluoroacetylimidazole
def: "Trifluoroacetylimidazole." [CAS:1546-79-8, PubChem_Compound:73767, Beilstein:608904, MDL:MFCD00014501, ChemSpiderID:66407, ChemicalBookNo:CB7308204, DOI:10.5772/33098]
synonym: "TFAI" EXACT []
is_a: XLMOD:06005 ! fluoracylimidazole reagent
is_a: XLMOD:06015 ! TFA reagent
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive

[Term]
id: XLMOD:07019
name: pentafluoropropanylimidazole
def: "Pentafluoropropanylimidazole." [DOI:10.5772/33098]
synonym: "PFPI" EXACT []
is_a: XLMOD:06005 ! fluoracylimidazole reagent
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive

[Term]
id: XLMOD:07020
name: heptafluorobutyrylimidazole
def: "Heptafluorobutyrylimidazole." [CAS:32477-35-3, PubChem_Compound:94431, MDL:MFCD00014503, ChemSpiderID:85218, ChemicalBookNo:CB4100522, DOI:10.5772/33098]
synonym: "HFBI" EXACT []
is_a: XLMOD:06005 ! fluoracylimidazole reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06502 ! amide reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06507 ! catecholamine reactive

[Term]
id: XLMOD:07021
name: N-Methyl-bis(trifluoroacetamide)
def: "N-Methyl-bis(trifluoroacetamide)." [CAS:685-27-8, PubChem_Compound:69635, Beilstein:1878402, MDL:MFCD00000412, ChemSpiderID:62836, ChemicalBookNo:CB0220312, DOI:10.5772/33098]
synonym: "MBTFA" EXACT []
is_a: XLMOD:06015 ! TFA reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive

[Term]
id: XLMOD:07022
name: pentafluorobenzoyl chloride
def: "Pentafluorobenzoyl chloride." [CAS:2251-50-5, PubChem_Compound:75256, Beilstein:2054397, MDL:MFCD00000657, ChemSpiderID:67799, ChemicalBookNo:CB6191348, DOI:10.5772/33098]
synonym: "PFBC" EXACT []
is_a: XLMOD:06003 ! acylation reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00155 ! acyl chloride

[Term]
id: XLMOD:07023
name: pentafluoropropanol
def: "Pentafluoropropanol." [CAS:679-86-7, PubChem_Compound:168785, MDL:MFCD00153226, ChemSpiderID:9488, ChemicalBookNo:CB9689963, DOI:10.5772/33098]
synonym: "PFPOH" EXACT []
is_a: XLMOD:06003 ! acylation reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive

[Term]
id: XLMOD:07024
name: 4-Carbethoxyhexafluorobutyrylchloride
def: "4-Carbethoxyhexafluorobutyrylchloride." [CAS:18381-53-8, PubChem_Compound:161251, ChemSpiderID:141651, ChemicalBookNo:CB2153034, DOI:10.5772/33098]
synonym: "4-CB" EXACT []
is_a: XLMOD:06003 ! acylation reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:07025
name: N-trifluoroacetyl-L-prolylchloride
def: "N-trifluoroacetyl-L-prolylchloride." [CAS:36724-68-2, PubChem_Compound:3082449, ChemicalBookNo:CB1411487, DOI:10.5772/33098]
synonym: "TPC" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:07026
name: (S)-(-)-N-(Trifluoroacetyl)-prolylchloride
def: "(S)-(-)-N-(Trifluoroacetyl)-prolylchloride." [CAS:36724-68-2, PubChem_Compound:3082449, ChemicalBookNo:3082449, DOI:10.5772/33098]
synonym: "I-TPC" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:07027
name: (-)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid
def: "(-)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid." [CAS:56135-03-6, PubChem_Compound:2723917, MDL:MFCD00066637, DOI:10.5772/33098]
synonym: "MTPA" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:07028
name: oximation reagent
def: "Oximation reagent replacing an aldehyde keto group with an O-methyloxime group." [PSI:XL]
is_a: XLMOD:06001 ! GCMS derivatization reagent

[Term]
id: XLMOD:07029
name: methoxylamine hydrochloride
def: "Methoxylamine hydrochloride." [CAS:593-56-6, PubChem_Compound:521874, MDL:MFCD00012951, Beilstein:3589723, ChemSpiderID:455236, ChemicalBookNo:CB3439014]
synonym: "O-Methylhydroxylamine hydrochloride" EXACT []
synonym: "Methoxyammonium chloride" EXACT []
is_a: XLMOD:06002 ! alkylation reagent
is_a: XLMOD:07028 ! oximation reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06506 ! carbohydrate reactive

[Term]
id: XLMOD:07030
name: Trimethyliodosilane
def: "Trimethyliodosilane." [PMID:26478271, PMID:26478271]
synonym: "TMIS" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06013 ! TMS reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:07031
name: deuterium labelled N-methyl-trimethylsilyltrifluoroacetamide
def: "Deuterium labelled N-methyl-trimethylsilyltrifluoroacetamide." [CAS:945623-67-6, ChemicalBookNo:CB72545465, PMID:23628173]
synonym: "MSTFA-d9" EXACT []
is_a: XLMOD:06013 ! TMS reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:07032
name: deuterium labelled N-methyl-N-t-butyldimethylsilyltrifluoroacetamide
def: "Deuterium labelled N-methyl-N-t-butyldimethylsilyltrifluoroacetamide." [PMID:23628173]
synonym: "MTBSTFA-d6" EXACT []
is_a: XLMOD:06014 ! DMS reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:06501 ! active hydrogen reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:07033
name: deuterium labelled methyl chloroformate
def: "Deuterium labelled methyl chloroformate." [PMID:23628173]
synonym: "MCF-d3" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:07034
name: methyl chloroformate
def: "Methyl chloroformate." [CAS:79-22-1, PubChem_Compound:6586, ChemSpiderID:6337]
synonym: "MCF" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:07035
name: 9-Fluorenylmethyl chloroformate
def: "9-Fluorenylmethyl chloroformate." [CAS:28920-43-6, ChemSpiderID:31647, ChemicalBookNo:CB7234569]
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:07036
name: trichloroethyl chloroformate
def: "Trichloroethyl chloroformate." [CAS:17341-93-4, PubChem_Compound:87063, ChemSpiderID:78534, ChemicalBookNo:CB1372973]
synonym: "TCECF" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:07037
name: pentafluorobenzyl chloroformate
def: "Pentafluorobenzyl chloroformate." [CAS:53526-74-2, PubChem_Compound:2775932, ChemSpiderID:2056259, ChemicalBookNo:CB8165220]
synonym: "PFBCF" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:07038
name: 1-chloroethyl chloroformate
def: "1-chloroethyl chloroformate." [CAS:50893-53-3, PubChem_Compound:521305, ChemSpiderID:454726, ChemicalBookNo:CB5320341]
synonym: "1CEF" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:07039
name: N-Acetylimidazole
def: "N-Acetylimidazole." [CAS:2466-76-4, PubChem_Compound:17174, ChemSpiderID:16257, ChemicalBookNo:CB9339608]
synonym: "AIM" EXACT []
is_a: XLMOD:06003 ! acylation reagent

[Term]
id: XLMOD:07040
name: 1,3-Bis(chloromethyl)-1,1,3,3-tetramethyldisilazane
def: "1,3-Bis(chloromethyl)-1,1,3,3-tetramethyldisilazane." [CAS:14579-91-0, PubChem_Compound:26740, ChemSpiderID:24914, ChemicalBookNo:CB1743876]
synonym: "CMTMS" EXACT []
is_a: XLMOD:06014 ! DMS reagent
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:07041
name: Dimethylchlorosilane
def: "Dimethylchlorosilane." [CAS:1066-35-9, PubChem_Compound:6327132, ChemSpiderID:59496, ChemicalBookNo:CB3694606]
synonym: "DMCS" EXACT []
is_a: XLMOD:06014 ! DMS reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:07042
name: N-Trimethylsilylacetamide
def: "N-Trimethylsilylacetamide." [CAS:13435-12-6, PubChem_Compound:25989, ChemSpiderID:24208, ChemicalBookNo:CB7667530]
synonym: "TMSA" EXACT []
synonym: "N-(Trimethylsilyl)acetamide" EXACT []
is_a: XLMOD:06013 ! TMS reagent
relationship: is_reactive_with XLMOD:06506 ! carbohydrate reactive

[Term]
id: XLMOD:07043
name: N-(Trimethylsilyl)diethylamine
def: "N-(Trimethylsilyl)diethylamine." [CAS:996-50-9, PubChem_Compound:70454, ChemSpiderID:63633, ChemicalBookNo:CB3771284]
synonym: "TMSDEA" EXACT []
is_a: XLMOD:06013 ! TMS reagent
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:07044
name: trimethylphenylammonium hydroxide
def: "Trimethylphenylammonium hydroxide." [CAS:1899-02-1, PubChem_Compound:15913, ChemSpiderID:15124, ChemicalBookNo:CB5316173]
synonym: "TMPAH" EXACT []
synonym: "MethElute reagent" EXACT []
is_a: XLMOD:06002 ! alkylation reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:06502 ! amide reactive

[Term]
id: XLMOD:07045
name: N,N-Dimethylformamidedimethyl acetal
def: "N,N-Dimethylformamidedimethyl acetal." [CAS:4637-24-5, PubChem_Compound:78373, ChemSpiderID:70742, ChemicalBookNo:CB8178244]
synonym: "DMFDMA" EXACT []
synonym: "Methylate reagent" EXACT []
is_a: XLMOD:06017 ! N,N-Dimethylformamidedialkyl acetal

[Term]
id: XLMOD:07046
name: dimethyldichlorosilane
def: "Dimethyldichlorosilane." [CAS:75-78-5, PubChem_Compound:6398, ChemSpiderID:6158, ChemicalBookNo:CB8854243]
synonym: "DMDCS" EXACT []
is_a: XLMOD:06014 ! DMS reagent

[Term]
id: XLMOD:07047
name: N-t-Butyldimethylsilylimidazole
def: "N-t-Butyldimethylsilylimidazole." [CAS:54925-64-3, PubChem_Compound:171385, ChemSpiderID:149827, ChemicalBookNo:CB1271225]
synonym: "TBDMSIM" EXACT []
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:07048
name: 4-Trimethylsiloxy-3-penten-2-one
def: "4-Trimethylsiloxy-3-penten-2-one." [CAS:13257-81-3, PubChem_Compound:6059369, ChemSpiderID:4518416, ChemicalBookNo:CB3457672]
is_a: XLMOD:06013 ! TMS reagent

[Term]
id: XLMOD:07049
name: bromotrimethylsilane
def: "Bromotrimethylsilane." [CAS:2857-97-8, PubChem_Compound:76113, ChemSpiderID:68599, ChemicalBookNo:CB9749809]
is_a: XLMOD:06013 ! TMS reagent

[Term]
id: XLMOD:07050
name: triisopropylsilyl chloride
def: "Triisopropylsilyl chloride." [CAS:13154-24-0, PubChem_Compound:139400, ChemSpiderID:122926, ChemicalBookNo:CB3405310]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:07051
name: triisopropylsilyl trifluoromethanesulfonate
def: "Triisopropylsilyl trifluoromethanesulfonate." [CAS:80522-42-5, PubChem_Compound:2724529, ChemSpiderID:2006662, ChemicalBookNo:CB5189874]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:07052
name: triethylsilyl trifluoromethanesulfonate
def: "Triethylsilyl trifluoromethanesulfonate." [CAS:79271-56-0, PubChem_Compound:2733308, ChemSpiderID:2015110, ChemicalBookNo:CB6298346]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:07053
name: chlorotriethylsilane
def: "Chlorotriethylsilane." [CAS:994-30-9, PubChem_Compound:13819, ChemSpiderID:13221, ChemicalBookNo:CB4746520]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:07054
name: chloro-dimethyl(pentafluorophenyl)silane
def: "Chloro-dimethyl(pentafluorophenyl)silane." [CAS:20082-71-7, PubChem_Compound:88361, ChemSpiderID:79715, ChemicalBookNo:CB8853291]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:07055
name: N-Methyl-N-trimethylsilyl-heptafluorobutyramide
def: "N-Methyl-N-trimethylsilyl-heptafluorobutyramide." [CAS:53296-64-3, PubChem_Compound:2775707, ChemSpiderID:2056039, ChemicalBookNo:CB1232811]
synonym: "Mshfba" EXACT []
is_a: XLMOD:06013 ! TMS reagent

[Term]
id: XLMOD:07056
name: N-Methyl-N-trimethylsilylacetamide
def: "N-Methyl-N-trimethylsilylacetamide." [CAS:7449-74-3, PubChem_Compound:81953, ChemSpiderID:73958, ChemicalBookNo:CB4355232]
is_a: XLMOD:06013 ! TMS reagent

[Term]
id: XLMOD:07057
name: hexamethyldisiloxane
def: "Hexamethyldisiloxane." [CAS:107-46-0, PubChem_Compound:24764, ChemSpiderID:23150, ChemicalBookNo:CB2446352]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:07058
name: 1,1,3,3-Tetramethyl-1,3-diphenyldisilazane
def: "1,1,3,3-Tetramethyl-1,3-diphenyldisilazane." [CAS:3449-26-1, PubChem_Compound:76988, ChemSpiderID:69434, ChemicalBookNo:CB7212822]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:07059
name: N,N-Dimethyltrimethylsilylamine
def: "N,N-Dimethyltrimethylsilylamine." [CAS:2083-91-2, PubChem_Compound:74965, ChemSpiderID:67521, ChemicalBookNo:CB1279847]
is_a: XLMOD:06013 ! TMS reagent

[Term]
id: XLMOD:07060
name: N,N'-Bis(trimethylsilyl)urea
def: "N,N'-Bis(trimethylsilyl)urea." [CAS:18297-63-7, PubChem_Compound:87562, ChemSpiderID:78992, ChemicalBookNo:CB6152161]
is_a: XLMOD:06013 ! TMS reagent

[Term]
id: XLMOD:07061
name: N,O-Bis(trimethylsilyl)carbamate
def: "N,O-Bis(trimethylsilyl)carbamate." [CAS:35342-88-2, PubChem_Compound:3015764, ChemSpiderID:2283833, ChemicalBookNo:CB2248969]
is_a: XLMOD:06013 ! TMS reagent

[Term]
id: XLMOD:07062
name: N,N-Bis(trimethylsilyl)methylamine
def: "N,N-Bis(trimethylsilyl)methylamine." [CAS:920-68-3, PubChem_Compound:70199, ChemSpiderID:63385, ChemicalBookNo:CB0439806]
is_a: XLMOD:06013 ! TMS reagent

[Term]
id: XLMOD:07063
name: bis(dimethylamino)dimethylsilane
def: "Bis(dimethylamino)dimethylsilane." [CAS:3768-58-9, PubChem_Compound:77384, ChemSpiderID:69798, ChemicalBookNo:CB1214899]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:07064
name: Trimethylsilyl methallylsulfinate
def: "Trimethylsilyl methallylsulfinate." [CAS:723336-86-5, PubChem_Compound:71312539, ChemSpiderID:28419285, ChemicalBookNo:CB32750948]
is_a: XLMOD:06013 ! TMS reagent

[Term]
id: XLMOD:07065
name: Triethylsilyl methallylsulfinate
def: "Triethylsilyl methallylsulfinate." [CAS:850418-19-8, PubChem_Compound:71312540, ChemSpiderID:35789839, ChemicalBookNo:CB42756013]
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:07066
name: tert-Butyldimethylsilyl methallylsulfinate
def: "Tert-Butyldimethylsilyl methallylsulfinate." [CAS:850418-20-1, PubChem_Compound:71312541, ChemSpiderID:35789840, ChemicalBookNo:CB72750946]
synonym: "SILMAS-TBS" EXACT []
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:07067
name: methyltrifluoromethanesulfonate
def: "Methyltrifluoromethanesulfonate." [CAS:333-27-7, PubChem_Compound:9526, ChemSpiderID:9153, ChemicalBookNo:CB9131563]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07068
name: ethyl trifluoromethanesulfonate
def: "Ethyl trifluoromethanesulfonate." [CAS:425-75-2, PubChem_Compound:67924, ChemSpiderID:61241, ChemicalBookNo:CB4332659]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07069
name: trichloroacetyl chloride
def: "Trichloroacetyl chloride." [CAS:76-02-8, PubChem_Compound:6420, ChemSpiderID:6180, ChemicalBookNo:CB6854254]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07070
name: 2-Thenoyltrifluoroacetone
def: "2-Thenoyltrifluoroacetone." [CAS:326-91-0, PubChem_Compound:5601, ChemSpiderID:5399, ChemicalBookNo:CB3219722]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07071
name: 2,2,6,6-Tetramethyl-3,5-heptanedione
def: "2,2,6,6-Tetramethyl-3,5-heptanedione." [CAS:1118-71-4, PubChem_Compound:70700, ChemSpiderID:63866, ChemicalBookNo:CB1373637]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07072
name: N-Methyl-bis-heptafluorobutyramide
def: "N-Methyl-bis-heptafluorobutyramide." [CAS:73980-71-9, PubChem_Compound:597974, ChemSpiderID:519801, ChemicalBookNo:CB6699309]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07073
name: N,N'-Diisopropyl-O-methylisourea
def: "N,N'-Diisopropyl-O-methylisourea." [CAS:54648-79-2, PubChem_Compound:383824, ChemSpiderID:340092, ChemicalBookNo:CB4130844]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07074
name: 3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic acid
def: "3,3,3-Trifluoro-2-methoxy-2-phenylpropanoic acid." [CAS:81655-41-6, PubChem_Compound:86531, ChemSpiderID:5360910, ChemicalBookNo:CB4264981]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07075
name: 6,6,7,7,8,8,8-Heptafluoro-2,2-dimethyl-3,5-octanedione
def: "6,6,7,7,8,8,8-Heptafluoro-2,2-dimethyl-3,5-octanedione." [CAS:17587-22-3, PubChem_Compound:28614, ChemSpiderID:26612, ChemicalBookNo:CB2271873]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07076
name: 4-Bromophenacyl trifluoro-methanesulfonate
def: "4-Bromophenacyl trifluoro-methanesulfonate." [CAS:93128-04-2, PubChem_Compound:125008, ChemSpiderID:111291, ChemicalBookNo:CB4137500]
synonym: "4-Bromophenacyl triflate" EXACT []
is_a: XLMOD:06004 ! acylation reagent
relationship: has_fluorophore XLMOD:06111 ! 4-bromophenacyl

[Term]
id: XLMOD:07077
name: 2,3-Diaminotoluene
def: "2,3-Diaminotoluene." [CAS:2687-25-4, PubChem_Compound:17593, ChemSpiderID:16633, ChemicalBookNo:CB2736932]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07078
name: 2,6-Diamino-4-pyrimidinone
def: "2,6-Diamino-4-pyrimidinone." [CAS:56-06-4, PubChem_Compound:2944, ChemSpiderID:2840, ChemicalBookNo:CB0174912]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07079
name: benzoic acid
def: "Benzoic acid." [CAS:65-85-0, PubChem_Compound:243, ChemSpiderID:238, ChemicalBookNo:CB8698780]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07080
name: tert-Butyl methyl ether
def: "Tert-Butyl methyl ether." [CAS:1634-04-4, PubChem_Compound:15413, ChemSpiderID:14672, ChemicalBookNo:CB2853178]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07081
name: ethyl acetoacetate
def: "Ethyl acetoacetate." [CAS:141-97-9, PubChem_Compound:8868, ChemSpiderID:13865426, ChemicalBookNo:CB0301721]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07082
name: (1S)-(+)-Menthyl chloroformate
def: "(1S)-(+)-Menthyl chloroformate." [CAS:7635-54-3, PubChem_Compound:2733329, ChemSpiderID:2015131, ChemicalBookNo:CB5397503]
is_a: XLMOD:06004 ! acylation reagent
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:07083
name: butylboronic acid
def: "Butylboronic acid." [CAS:4426-47-5, PubChem_Compound:20479, ChemSpiderID:19286, ChemicalBookNo:CB6431756]
is_a: XLMOD:06004 ! acylation reagent
relationship: has_reactive_group XLMOD:00161 ! boronic acid

[Term]
id: XLMOD:07084
name: 1-(Pentafluoropropionyl) imidazole
def: "1-(Pentafluoropropionyl) imidazole." [CAS:71735-32-5, PubChem_Compound:100821, ChemSpiderID:91097, ChemicalBookNo:CB8441122]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07085
name: hexafluoroacetylacetone
def: "Hexafluoroacetylacetone." [CAS:1522-22-1, PubChem_Compound:73706, ChemSpiderID:21106446, ChemicalBookNo:CB8188414]
synonym: "Hexafluoro-2,4-pentanedione" EXACT []
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07086
name: 2,3,4,5,6-Pentafluorobenzaldehyde
def: "2,3,4,5,6-Pentafluorobenzaldehyde." [CAS:653-37-2, PubChem_Compound:69558, ChemSpiderID:21106527, ChemicalBookNo:CB6754598]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07087
name: pentafluorobenzenesulfonyl chloride
def: "Pentafluorobenzenesulfonyl chloride." [CAS:832-53-1, PubChem_Compound:70026, ChemSpiderID:63216, ChemicalBookNo:CB7243712]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07088
name: 1,1,1-Trifluoro-2,4-pentanedione
def: "1,1,1-Trifluoro-2,4-pentanedione." [CAS:367-57-7, PubChem_Compound:73943, ChemSpiderID:66573, ChemicalBookNo:CB6699233]
is_a: XLMOD:06015 ! TFA reagent

[Term]
id: XLMOD:07089
name: 1,1,1-Trifluoroacetone
def: "1,1,1-Trifluoroacetone." [CAS:421-50-1, PubChem_Compound:9871, ChemSpiderID:21111803, ChemicalBookNo:CB4123453]
is_a: XLMOD:06015 ! TFA reagent

[Term]
id: XLMOD:07090
name: 4-(Trifluoromethyl)benzoyl chloride
def: "4-(Trifluoromethyl)benzoyl chloride." [CAS:329-15-7, PubChem_Compound:67607, ChemSpiderID:60927, ChemicalBookNo:CB9762316]
is_a: XLMOD:06015 ! TFA reagent

[Term]
id: XLMOD:07091
name: 8-Quinolinesulfonyl chloride
def: "8-Quinolinesulfonyl chloride." [CAS:18704-37-5, PubChem_Compound:29220, ChemSpiderID:27177, ChemicalBookNo:CB8329163]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07092
name: (1R)-(-)-Menthyl chloroformate
def: "(1R)-(-)-Menthyl chloroformate." [CAS:14602-86-9, PubChem_Compound:7014897, ChemSpiderID:17206727, ChemicalBookNo:CB7248919]
is_a: XLMOD:06004 ! acylation reagent
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:07093
name: phenylboronic acid
def: "Phenylboronic acid." [CAS:98-80-6, PubChem_Compound:66827, ChemSpiderID:60191, ChemicalBookNo:CB5323625]
is_a: XLMOD:06004 ! acylation reagent
relationship: has_reactive_group XLMOD:00161 ! boronic acid

[Term]
id: XLMOD:07094
name: methylboronic acid
def: "Methylboronic acid." [CAS:13061-96-6, PubChem_Compound:139377, ChemSpiderID:122904, ChemicalBookNo:CB3373202]
is_a: XLMOD:06004 ! acylation reagent
relationship: has_reactive_group XLMOD:00161 ! boronic acid

[Term]
id: XLMOD:07095
name: 2,3,4,5,6-Pentafluorobenzoic anhydride
def: "2,3,4,5,6-Pentafluorobenzoic anhydride." [CAS:15989-99-8, PubChem_Compound:189034, ChemSpiderID:164254, ChemicalBookNo:CB3497119]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07096
name: 4-(Dimethylamino)benzoyl chloride
def: "4-(Dimethylamino)benzoyl chloride." [CAS:4755-50-4, PubChem_Compound:4400782, ChemSpiderID:3601987, ChemicalBookNo:CB6399872]
is_a: XLMOD:06004 ! acylation reagent

[Term]
id: XLMOD:07097
name: boron trifluoride butanol
def: "Boron trifluoride butanol." [CAS:7637-07-2, PubChem_Compound:6356, ChemSpiderID:6116, ChemicalBookNo:CB3238105]
synonym: "BF3-butanol" EXACT []
is_a: XLMOD:06016 ! boron trifluoride reagent

[Term]
id: XLMOD:07098
name: 1,1,1,3,3,3-Hexafluoro-2-propanol
def: "1,1,1,3,3,3-Hexafluoro-2-propanol." [CAS:920-66-1, PubChem_Compound:13529, ChemSpiderID:10606755, ChemicalBookNo:CB3251829]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07099
name: 2,2,3,3,3-Pentafluoro-1-propanol
def: "2,2,3,3,3-Pentafluoro-1-propanol." [CAS:422-05-9, PubChem_Compound:9872, ChemSpiderID:9488, ChemicalBookNo:CB9689963]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07100
name: 2,3,5,6-Tetrafluoro-4-ethanol(trifluoromethyl)benzyl bromide
def: "2,3,5,6-Tetrafluoro-4-ethanol(trifluoromethyl)benzyl bromide." [CAS:76437-40-6, PubChem_Compound:127137, ChemSpiderID:112859, ChemicalBookNo:CB1682115]
is_a: XLMOD:06002 ! alkylation reagent
relationship: has_reactive_group XLMOD:00168 ! benzyl bromide reactive group

[Term]
id: XLMOD:07101
name: 2,3-Dihydroxy-biphenyl
def: "2,3-Dihydroxy-biphenyl." [CAS:1133-63-7, PubChem_Compound:254, ChemSpiderID:249, ChemicalBookNo:CB0302647]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07102
name: O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride
def: "O-(2,3,4,5,6-Pentafluorobenzyl)hydroxylamine hydrochloride." [CAS:57981-02-9, PubChem_Compound:122307, ChemSpiderID:109062, ChemicalBookNo:CB8307815]
synonym: "Florox reagent" EXACT []
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07103
name: pentafluoroiodoethane
def: "Pentafluoroiodoethane." [CAS:354-64-3, PubChem_Compound:9636, ChemSpiderID:9259, ChemicalBookNo:CB1226715]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07104
name: tetrabutylammoniumtetrabutylborate
def: "Tetrabutylammoniumtetrabutylborate." [CAS:23231-91-6, PubChem_Compound:11123692, ChemSpiderID:9298821, ChemicalBookNo:CB9765711]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07105
name: trimethylboroxine
def: "Trimethylboroxine." [CAS:823-96-1, PubChem_Compound:574072, ChemSpiderID:499140, ChemicalBookNo:499140]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07107
name: boron trifluoride propanol
def: "Boron trifluoride propanol." [CAS:762-48-1, ChemSpiderID:11428571, ChemicalBookNo:CB7289428]
synonym: "BF3-propanol" EXACT []
is_a: XLMOD:06016 ! boron trifluoride reagent

[Term]
id: XLMOD:07108
name: 4-Bromobenzyl bromide
def: "4-Bromobenzyl bromide." [CAS:589-15-1, PubChem_Compound:68527, ChemSpiderID:61802, ChemicalBookNo:CB8313784]
is_a: XLMOD:06020 ! arylation reagent
relationship: has_reactive_group XLMOD:00168 ! benzyl bromide reactive group

[Term]
id: XLMOD:07109
name: N,N-Dimethylformamidediethyl acetal
def: "N,N-Dimethylformamidediethyl acetal." [CAS:1188-33-6, PubChem_Compound:70913, ChemSpiderID:64076, ChemicalBookNo:CB6665913]
synonym: "1,1-Diethoxy-N,N-dimethylmethanamine" EXACT []
is_a: XLMOD:06017 ! N,N-Dimethylformamidedialkyl acetal

[Term]
id: XLMOD:07110
name: N,N-Dimethylformamidedibutyl acetal
def: "N,N-Dimethylformamidedibutyl acetal." [CAS:18503-90-7, PubChem_Compound:87683, ChemSpiderID:79103, ChemicalBookNo:CB8770217]
synonym: "1,1-Dibutoxy-N,N-dimethylmethanamine" EXACT []
is_a: XLMOD:06017 ! N,N-Dimethylformamidedialkyl acetal

[Term]
id: XLMOD:07111
name: N,N-Dimethylformamidediisopropyl acetal
def: "N,N-Dimethylformamidediisopropyl acetal." [CAS:18503-89-4, PubChem_Compound:87682, ChemSpiderID:79102, ChemicalBookNo:CB1137822]
is_a: XLMOD:06017 ! N,N-Dimethylformamidedialkyl acetal

[Term]
id: XLMOD:07112
name: N,N-Dimethylformamidedineopentyl acetal
def: "N,N-Dimethylformamidedineopentyl acetal." [CAS:4909-78-8, PubChem_Compound:78623, ChemSpiderID:70980, ChemicalBookNo:CB1335538]
is_a: XLMOD:06017 ! N,N-Dimethylformamidedialkyl acetal

[Term]
id: XLMOD:07113
name: N,N-Dimethylformamidedipropyl acetal
def: "N,N-Dimethylformamidedipropyl acetal." [CAS:6006-65-1, PubChem_Compound:80105, ChemSpiderID:72355, ChemicalBookNo:CB4137823]
is_a: XLMOD:06017 ! N,N-Dimethylformamidedialkyl acetal

[Term]
id: XLMOD:07114
name: N,N-Dimethylformamidedi-tert-butyl acetal
def: "N,N-Dimethylformamidedi-tert-butyl acetal." [CAS:36805-97-7, PubChem_Compound:547712, ChemSpiderID:476708, ChemicalBookNo:CB5296219]
is_a: XLMOD:06017 ! N,N-Dimethylformamidedialkyl acetal

[Term]
id: XLMOD:07115
name: nonafluoro-1-iodobutane
def: "Nonafluoro-1-iodobutane." [CAS:423-39-2, PubChem_Compound:67917, ChemSpiderID:61234, ChemicalBookNo:CB9474482]
synonym: "Perfluorobutyl iodide" EXACT []
synonym: "1-Iodoperfluorobutane" EXACT []
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07116
name: triethyloxonium tetrafluoroborate
def: "Triethyloxonium tetrafluoroborate." [CAS:368-39-8, PubChem_Compound:2723982, ChemSpiderID:2006158, ChemicalBookNo:CB0198800]
is_a: XLMOD:06019 ! trialkyloxonium reagent

[Term]
id: XLMOD:07117
name: 2,2,2-Trichloroethanol
def: "2,2,2-Trichloroethanol." [CAS:115-20-8, PubChem_Compound:8259, ChemSpiderID:7961, ChemicalBookNo:CB7257753]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07118
name: triethyloxonium hexafluorophosphate
def: "Triethyloxonium hexafluorophosphate." [CAS:17950-40-2, PubChem_Compound:167684, ChemSpiderID:146692, ChemicalBookNo:CB4151711]
is_a: XLMOD:06019 ! trialkyloxonium reagent

[Term]
id: XLMOD:07119
name: 2,2,2-Trifluoroethanol
def: "2,2,2-Trifluoroethanol." [CAS:75-89-8, PubChem_Compound:6409, ChemSpiderID:21106169, ChemicalBookNo:CB5736665]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07120
name: trimethyloxonium tetrafluoroborate
def: "Trimethyloxonium tetrafluoroborate." [CAS:420-37-1, PubChem_Compound:2735153, ChemSpiderID:2016863, ChemicalBookNo:CB3184284]
is_a: XLMOD:06019 ! trialkyloxonium reagent

[Term]
id: XLMOD:07121
name: 2,2-Dimethoxypropane
def: "2,2-Dimethoxypropane." [CAS:77-76-9, PubChem_Compound:6495, ChemSpiderID:21106033, ChemicalBookNo:CB9373512]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07122
name: 4-Tolylsulfonylmethylnitrosamide
def: "4-Tolylsulfonylmethylnitrosamide." [CAS:80-11-5, PubChem_Compound:6628, ChemSpiderID:6376, ChemicalBookNo:CB7663729]
synonym: "Diazald" EXACT []
synonym: "N-Methyl-N-nitrosotoluene-4-sulphonamide" EXACT []
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07123
name: 18-Crown-6
def: "18-Crown-6." [CAS:17455-13-9, PubChem_Compound:28557, ChemSpiderID:26563, ChemicalBookNo:CB4445218]
is_a: XLMOD:06002 ! alkylation reagent

[Term]
id: XLMOD:07124
name: 3-Aminopropyltriethoxysilane
def: "3-Aminopropyltriethoxysilane." [CAS:919-30-2, PubChem_Compound:13521, ChemSpiderID:12933, ChemicalBookNo:CB8686147]
synonym: "APTES" EXACT []
is_a: XLMOD:06003 ! silylation reagent

[Term]
id: XLMOD:09000
name: dansyl chloride
def: "Dansyl chloride." [CAS:605-65-2, PubChem_Compound:14513518, ChemSpiderID:11308, ChemicalBookNo:CB5696240, PMID:23524938]
synonym: "DNS-Cl" EXACT []
synonym: "5-dimethylamino-1-naphthalenesulfonyl chloride" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00156 ! sulfonyl chloride
relationship: is_reactive_with XLMOD:06512 ! steroid reactive
relationship: is_reactive_with XLMOD:06515 ! nucleoside reactive

[Term]
id: XLMOD:09001
name: picolinic acid
def: "Picolinic acid." [CAS:98-98-6, PubChem_Compound:1018, ChemSpiderID:993, ChemicalBookNo:CB8196640, PMID:23524938]
synonym: "PA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09002
name: fusaric acid
def: "Fusaric acid." [CAS:536-69-6, PubChem_Compound:3442, ChemSpiderID:3324, ChemicalBookNo:CB4689029, PMID:23524938]
synonym: "FA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive

[Term]
id: XLMOD:09003
name: dimethylglycine
def: "Dimethylglycine." [CAS:1118-68-9, PubChem_Compound:673, ChemSpiderID:653, ChemicalBookNo:1118-68-9, PMID:23524938]
synonym: "N,N-Dimethylglycine" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive

[Term]
id: XLMOD:09004
name: isonicotinoyl azide
def: "Isonicotinoyl azide." [PubChem_Compound:11701058, ChemSpiderID:9875783, ChemicalBookNo:CB1385038, PMID:23524938, PMID:26454158]
synonym: "INA" EXACT []
synonym: "Pyridine-4-carbonyl azide" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09005
name: NA-NHS ester
def: "N-hydroxysuccinimide esters of N-alkyl(C1-C4)nicotinic acids." [PMID:16808485, PMID:22575224]
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09006
name: 2-fluoro-1-methylpyridinium p-toluenesulfonate
def: "2-fluoro-1-methylpyridinium p-toluenesulfonate." [CAS:58086-67-2, ChemSpiderID:150036, ChemicalBookNo:CB1142305, PMID:23524938]
synonym: "FMP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00165 ! sulfonate
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09007
name: 3-nitrophthalic anhydride
def: "3-nitrophthalic anhydride." [CAS:641-70-3, PubChem_Compound:21631, ChemSpiderID:20330, ChemicalBookNo:CB8116378, PMID:7802865, PMID:23524938]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00166 ! anhydride

[Term]
id: XLMOD:09008
name: 2-hydrazino-1-methylpyridine
def: "2-hydrazino-1-methylpyridine." [ChemSpiderID:21376238, PMID:23524938]
synonym: "HMP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09009
name: 2-hydrazinopyridine
def: "2-hydrazinopyridine." [CAS:4930-98-7, PubChem_Compound:78645, ChemSpiderID:71000, ChemicalBookNo:CB0389206, PMID:23524938, PMID:26454158]
synonym: "HP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09010
name: dansyl hydrazine
def: "Dansyl hydrazine." [CAS:33008-06-9, PubChem_Compound:94442, ChemSpiderID:85229, ChemicalBookNo:CB9236754, PMID:23524938]
synonym: "Dns-Hz" EXACT []
synonym: "DH" EXACT []
synonym: "5-dimethylaminonaphthalene-1-sulfonyl hydrazine" EXACT []
synonym: "5-(Dimethylamino)-1-naphthalenesulfonohydrazide" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09011
name: Girard's reagent P
def: "Pyridinioacetohydrazide chloride." [CAS:1126-58-5, PubChem_Compound:70773, ChemSpiderID:63938, ChemicalBookNo:CB2285753, PMID:23524938]
synonym: "Gir P" EXACT []
synonym: "GP" EXACT []
synonym: "1-(carboxymethyl)pyridium chloride hydrazide" EXACT []
synonym: "1-(2-hydrazino-2-oxoethyl)pyridinium chloride" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09012
name: Girard's reagent T
def: "Betaine Hydrazide Hydrochloride." [CAS:123-46-6, PubChem_Compound:67156, ChemSpiderID:60501, ChemicalBookNo:CB9414297, PMID:23524938]
synonym: "Gir T" EXACT []
synonym: "GT" EXACT []
synonym: "1-(carboxymethyl)trimethylammonium chloride hydrazide" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: is_reactive_with XLMOD:06515 ! nucleoside reactive

[Term]
id: XLMOD:09013
name: 2,4-dinitrophenylhydrazine
def: "2,4-dinitrophenylhydrazine." [CAS:119-26-6, PubChem_Compound:3772977, ChemSpiderID:3001507, ChemicalBookNo:CB4852908, PMID:23524938]
synonym: "DNPH" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_fluorophore XLMOD:06104 ! 2,4-dinitrophenyl
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09014
name: hydroxylamine
def: "Hydroxylamine." [CAS:7803-49-8, PubChem_Compound:787, ChemSpiderID:766, ChemicalBookNo:CB3345090, PMID:23524938]
synonym: "HA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00133 ! amine reactive group
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09015
name: 4-[2-(Trimethylammonio)ethoxy]anilinium dibromide
def: "4-[2-(Trimethylammonio)ethoxy]anilinium dibromide." [CAS:1076196-38-7, ChemSpiderID:29342342, ChemicalBookNo:CB32747247, PMID:23524938]
synonym: "4-APC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09016
name: 4-(2-((4-bromophenethyl)dimethylammonio)ethoxy)benzenaminium dibromide
def: "4-(2-((4-bromophenethyl)dimethylammonio)ethoxy)benzenaminium dibromide." [CAS:197305-97-8, PubChem_Compound:91826487, ChemSpiderID:1064766, ChemicalBookNo:CB7444959, PMID:23524938]
synonym: "4-APEBA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09017
name: D-Cysteine
def: "D-Cysteine." [CAS:921-01-7, PubChem_Compound:92851, ChemSpiderID:83819, ChemicalBookNo:CB4407452, PMID:23524938]
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09018
name: 2-Picolylamine
def: "2-Picolylamine." [CAS:3731-51-9, PubChem_Compound:19509, ChemSpiderID:18383, ChemicalBookNo:CB8853569, PMID:23524938]
synonym: "2-PA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09019
name: 3-Picolylamine
def: "3-Picolylamine." [CAS:3731-52-0, PubChem_Compound:31018, ChemSpiderID:28777, ChemicalBookNo:CB2284635, PMID:23524938]
synonym: "3-PA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09020
name: 3-picolylcarbinol
def: "3-picolylcarbinol." [ChemSpiderID:72714, PMID:23524938]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09021
name: 3-Hydroxy-1-methyl-piperidine
def: "3-Hydroxy-1-methyl-piperidine." [CAS:3554-74-3, PubChem_Compound:98016, ChemSpiderID:88489, ChemicalBookNo:CB7340664, PMID:23524938]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09022
name: 3-(Hydroxymethyl)-pyridine
def: "3-(Hydroxymethyl)-pyridine." [CAS:100-55-0, PubChem_Compound:7510, ChemSpiderID:7229, ChemicalBookNo:CB6384809, PMID:23524938]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09023
name: 4-Diazomethylpyridine
def: "4-Diazomethylpyridine." [CAS:26363-69-9, PubChem_Compound:12066686, ChemSpiderID:57445102, PMID:23524938]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09024
name: 4-[2-(N,Ndimethylamino)ethylaminosulfonyl]-7-(2-aminoethylamino)-2,1,3-benzoxadiazole
def: "4-[2-(N,Ndimethylamino)ethylaminosulfonyl]-7-(2-aminoethylamino)-2,1,3-benzoxadiazole." [CAS:913253-56-2, PubChem_Compound:91247932, ChemSpiderID:21377953, ChemicalBookNo:CB62720627, PMID:23524938]
synonym: "DAABD-AE" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09025
name: 1-Butanol hydrochloride
def: "1-Butanol hydrochloride." [ChemSpiderID:13206062, PMID:23524938]
synonym: "Butanol + HCl" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09026
name: fluorenylmethyloxycarbonyl chloride
def: "Fluorenylmethyloxycarbonyl chloride." [CAS:28920-43-6, PubChem_Compound:34367, ChemSpiderID:31647, ChemicalBookNo:CB7234569, PMID:23524938]
synonym: "FMOC-Cl" EXACT []
synonym: "1-(9-Fluorenyl)methyl chloroformate" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:09027
name: N-Methyl-2-phenylethanamide
def: "N-Methyl-2-phenylethanamide." [CAS:6830-82-6, PubChem_Compound:81274, ChemSpiderID:73329, ChemicalBookNo:CB4717700, PMID:23524938]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09028
name: 2-Bromo-1-(4-(dimethylamino)phenyl)ethanone
def: "2-Bromo-1-(4-(dimethylamino)phenyl)ethanone." [CAS:37904-72-6, PubChem_Compound:142225, ChemSpiderID:125460, ChemicalBookNo:CB4113692, PMID:23524938]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09029
name: 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate
def: "6-aminoquinolyl-N-hydroxysuccinimidyl carbamate." [ChemSpiderID:2043270, PMID:23524938, PMID:16384748]
synonym: "6-ACQ" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00164 ! carbamate

[Term]
id: XLMOD:09030
name: 3-Pyridyl isothiocyanate
def: "3-Pyridyl isothiocyanate." [CAS:17452-27-6, PubChem_Compound:2737242, ChemSpiderID:2018885, ChemicalBookNo:CB4371720, PMID:23524938]
synonym: "3-Isothiocyanatopyridine" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00162 ! isothiocyanate

[Term]
id: XLMOD:09031
name: phenyl isothiocyanate
def: "Phenyl isothiocyanate." [CAS:103-72-0, PubChem_Compound:7673, ChemSpiderID:7390, ChemicalBookNo:CB5733806, PMID:23524938, PMID:26496130]
synonym: "PITC" EXACT []
synonym: "Edman's reagent" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00162 ! isothiocyanate

[Term]
id: XLMOD:09032
name: isobutyl chloroformate
def: "Isobutyl chloroformate." [CAS:543-27-1, PubChem_Compound:62365, ChemSpiderID:56154, ChemicalBookNo:CB7165612, PMID:23524938]
synonym: "IBCF" EXACT []
synonym: "i-BuCF" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent
relationship: is_reactive_with XLMOD:06511 ! biphosphonate drug reactive

[Term]
id: XLMOD:09033
name: 4-(N,N-Dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole
def: "4-(N,N-Dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole." [CAS:98358-90-8, PubChem_Compound:126917, ChemSpiderID:112705, ChemicalBookNo:CB3366336, PMID:23524938, PMID:27582321]
synonym: "DBD-F" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00158 ! halobenzofurazan
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09034
name: 4-Bromophenacyl bromide
def: "4-Bromophenacyl bromide." [CAS:99-73-0, PubChem_Compound:7454, ChemSpiderID:7174, ChemicalBookNo:CB4239093, PMID:23524938]
synonym: "BPBr" EXACT []
synonym: "p-Bromophenacyl bromide" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_fluorophore XLMOD:06111 ! 4-bromophenacyl
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06522 ! perfluorinated carboxylic acid reactive

[Term]
id: XLMOD:09035
name: ethyl bromoacetate
def: "Ethyl bromoacetate." [CAS:105-36-2, PubChem_Compound:7748, ChemSpiderID:7462, ChemicalBookNo:CB6852654, PMID:23524938]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09036
name: (2-[4-aminophenoxy]ethyl)trimethylammonium bromide
def: "(2-[4-aminophenoxy]ethyl)trimethylammonium bromide." [ChemSpiderID:24770517, PMID:22191594]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive

[Term]
id: XLMOD:09037
name: hydroxylammonium chloride
def: "Hydroxylammonium chloride." [CAS:5470-11-1, PubChem_Compound:443297, ChemSpiderID:391543, ChemicalBookNo:CB8128885, PMID:22191594]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive

[Term]
id: XLMOD:09038
name: 4-Bromobenzenesulfonyl chloride
def: "4-Bromobenzenesulfonyl chloride." [CAS:98-58-8, ChemSpiderID:7118, ChemicalBookNo:CB8443863, PMID:22191594]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00156 ! sulfonyl chloride

[Term]
id: XLMOD:09039
name: 7-fluoro-4-nitrobenzoxadiazole
def: "7-fluoro-4-nitrobenzoxadiazole." [PubChem_Compound:53744831, ChemSpiderID:21375215, PMID:22191594]
synonym: "NBD-F" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09040
name: diacetyl-L-tartaric anhydride
def: "Diacetyl-L-tartaric anhydride." [CAS:6283-74-5, PubChem_Compound:102020809, ChemSpiderID:448369, ChemicalBookNo:CB0717661, PMID:22191594, PMID:26496130]
synonym: "DATAN" EXACT []
synonym: "DATAAN" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00166 ! anhydride
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09041
name: pentafluorophenacyl trifluoromethanesulfonate
def: "Pentafluorophenacyl trifluoromethanesulfonate." [PubChem_Compound:86038332, PMID:22191594]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_fluorophore XLMOD:06110 ! phenacyl
relationship: has_reactive_group XLMOD:00165 ! sulfonate
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09042
name: propyl chloroformate
def: "Propyl chloroformate." [CAS:109-61-5, PubChem_Compound:7998, ChemSpiderID:7707, ChemicalBookNo:CB9852781, PMID:22191594]
synonym: "PrCl" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:09043
name: 12,4-dinitrofluorobenzene
def: "12,4-dinitrofluorobenzene." [CAS:70-34-8, PubChem_Compound:6264, ChemSpiderID:21106037, ChemicalBookNo:CB9442373, PMID:22191594]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09044
name: trimethylsilyldiazomethane
def: "Trimethylsilyldiazomethane." [CAS:18107-18-1, PubChem_Compound:167693, ChemSpiderID:146699, ChemicalBookNo:CB9432840, PMID:22191594, PMID:19525080]
synonym: "TMS-DAM" EXACT []
synonym: "TMS-DM" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
is_a: XLMOD:06013 ! TMS reagent
relationship: is_reactive_with XLMOD:06511 ! biphosphonate drug reactive

[Term]
id: XLMOD:09045
name: trimethyl orthoacetate
def: "1,1,1-Trimethoxyethane." [CAS:1445-45-0, PubChem_Compound:15050, ChemSpiderID:14322, ChemicalBookNo:CB5759743, PMID:22191594]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06511 ! biphosphonate drug reactive

[Term]
id: XLMOD:09046
name: 3-(Perfluorooctyl)propylamine
def: "3-(Perfluorooctyl)propylamine." [CAS:139175-50-1, PubChem_Compound:10743224, ChemSpiderID:8918555, ChemicalBookNo:CB8736444, PMID:22191594]
synonym: "Heptadecafluoroundecylamine" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09047
name: dimethylaminoethanol
def: "Dimethylaminoethanol." [CAS:108-01-0, PubChem_Compound:7902, ChemSpiderID:8488535, ChemicalBookNo:CB6256870, PMID:22191594, PMID:26477276]
synonym: "DMAE" EXACT []
synonym: "Deanol" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09048
name: 4-nitrobenzyl bromide
def: "4-nitrobenzyl bromide." [CAS:100-11-8, PubChem_Compound:66011, ChemSpiderID:59402, ChemicalBookNo:CB5485712, PMID:3394930]
synonym: "4-NBB" EXACT []
synonym: "p-nitrobenzyl bromide" EXACT []
is_a: XLMOD:06020 ! arylation reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00168 ! benzyl bromide reactive group

[Term]
id: XLMOD:09049
name: 2,3-pyridinedicarboxylic anhydride
def: "2,3-pyridinedicarboxylic anhydride." [CAS:699-98-9, ChemSpiderID:62889, ChemicalBookNo:CB5268658, PMID:22191594]
synonym: "Furo(3,4-B)Pyridine-5,7-dione" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00166 ! anhydride
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09050
name: ethoxyamine hydrochloride
def: "Ethoxyamine hydrochloride." [CAS:3332-29-4, PubChem_Compound:76850, ChemSpiderID:69303, ChemicalBookNo:CB0126027, PMID:22191594]
synonym: "Ethylhydroxylamine hydrochloride" EXACT []
is_a: XLMOD:06002 ! alkylation reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09051
name: 4-(N,N-Dimethylaminosulfonyl)-7-hydrazino-2,1,3-benzoxadiazole
def: "4-(N,N-Dimethylaminosulfonyl)-7-hydrazino-2,1,3-benzoxadiazole." [CAS:131467-86-2, PubChem_Compound:131382, ChemSpiderID:116132, ChemicalBookNo:CB8688813, PMID:22191594]
synonym: "DBD-H" EXACT []
synonym: "4-(N,N-Dimethylsulfamoyl)-7-hydrazino-benzofurazan" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09052
name: 1-(5-Fluoro-2,4-dinitrophenyl)-4-methylpiperazine
def: "1-(5-Fluoro-2,4-dinitrophenyl)-4-methylpiperazine." [ChemSpiderID:17350721, PMID:22191594, PMID:26454158]
synonym: "PPZ" EXACT []
synonym: "1-(2,4-dinitro-5-fluorophenyl)-4-methylpiperazine" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_fluorophore XLMOD:06104 ! 2,4-dinitrophenyl
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09053
name: 4-nitrobenzoyl chloride
def: "4-nitrobenzoyl chloride." [CAS:122-04-3, PubChem_Compound:8502, ChemSpiderID:8188, ChemicalBookNo:CB2182076, PMID:22191594]
synonym: "4-NBC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00155 ! acyl chloride
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09054
name: pyridine-3-sulfonyl chloride
def: "Pyridine-3-sulfonyl chloride." [CAS:16133-25-8, PubChem_Compound:3164136, ChemSpiderID:2415634, ChemicalBookNo:CB5153121, PMID:26477276, PMID:22191594]
synonym: "PSCl" EXACT []
synonym: "chloro-3-pyridylsulfone" EXACT []
synonym: "pyridinium-3-sulfonyl chloride" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00156 ! sulfonyl chloride
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09055
name: methyl acrylate
def: "Methyl acrylate." [CAS:96-33-3, PubChem_Compound:7294, ChemSpiderID:7022, ChemicalBookNo:CB8669773, PMID:22191594]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09056
name: iodoacetic acid
def: "Iodoacetic acid." [CAS:64-69-7, PubChem_Compound:5240, ChemSpiderID:5050, ChemicalBookNo:CB3854071, PMID:22191594]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09057
name: 2-Bromo-3'-methoxyacetophenone
def: "2-Bromo-3'-methoxyacetophenone." [CAS:5000-65-7, PubChem_Compound:101294, ChemSpiderID:91526, ChemicalBookNo:CB3100727, PMID:22191594]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09058
name: monobromobimane
def: "Monobromobimane." [CAS:71418-44-5, PubChem_Compound:114810, ChemSpiderID:102775, ChemicalBookNo:CB0729365, PMID:22191594]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09059
name: 4-bromo-phenacyl-bromide
def: "4-bromo-phenacyl-bromide." [CAS:99-73-0, PubChem_Compound:7454, ChemSpiderID:7174, ChemicalBookNo:CB4239093, PMID:22191594]
synonym: "p-BPB" EXACT []
synonym: "p-bromo-phenacyl-bromide" EXACT []
synonym: "2,4'-Dibromoacetophenone" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_fluorophore XLMOD:06111 ! 4-bromophenacyl
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09060
name: 4-bromomethyl-7-methoxycoumarin
def: "4-bromomethyl-7-methoxycoumarin." [CAS:35231-44-8, PubChem_Compound:121894, ChemSpiderID:108742, ChemicalBookNo:CB6345309, PMID:22191594, PMID:15897015, PMID:19525080, PMID:3394930]
synonym: "Br-MMC" EXACT []
synonym: "BrMMC" EXACT []
synonym: "BMC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:06515 ! nucleoside reactive

[Term]
id: XLMOD:09061
name: Cookson type reagent
def: "4-substituted 1,2,4-triazoline-3,5-dione (TAD)." [PMID:14598004]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00160 ! TAD

[Term]
id: XLMOD:09062
name: 4-(4'-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione
def: "4-(4'-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione." [PMID:24097402]
synonym: "DAPTAD" EXACT []
is_a: XLMOD:09061 ! Cookson type reagent
relationship: has_reactive_group XLMOD:00160 ! TAD

[Term]
id: XLMOD:09063
name: 4-Phenyl-1,2,4-triazole-3,5-dione
def: "4-Phenyl-1,2,4-triazole-3,5-dione." [CAS:4233-33-4, ChemSpiderID:70304, ChemicalBookNo:CB3769656, PMID:14598004, PMID:26454158]
synonym: "PTAD" EXACT []
is_a: XLMOD:09061 ! Cookson type reagent
relationship: has_reactive_group XLMOD:00160 ! TAD

[Term]
id: XLMOD:09064
name: 4-[2-(6,7-dimethoxy-4-methyl-3-oxo-3,4-dihydroquinoxalyl)ethyl]-TAD
def: "4-[2-(6,7-dimethoxy-4-methyl-3-oxo-3,4-dihydroquinoxalyl)ethyl]-TAD." [CAS:132788-52-4, PubChem_Compound:131554, ChemSpiderID:116261, ChemicalBookNo:CB9453782, PMID:17077543, PMID:27511712]
synonym: "DMEQTAD" EXACT []
is_a: XLMOD:09061 ! Cookson type reagent
relationship: has_reactive_group XLMOD:00160 ! TAD

[Term]
id: XLMOD:09065
name: 4-[4-(6-methoxy-2-benzoxazolyl)phenyl]-1,2,4-triazoline-3,5-dione
def: "4-[4-(6-methoxy-2-benzoxazolyl)phenyl]-1,2,4-triazoline-3,5-dione." [PMID:15897015, PMID:27511712]
synonym: "MBOTAD" EXACT []
is_a: XLMOD:09061 ! Cookson type reagent
relationship: has_reactive_group XLMOD:00160 ! TAD

[Term]
id: XLMOD:09066
name: 4-(4-Nitrophenyl)-1,2,4-triazole-3,5-dione
def: "4-(4-Nitrophenyl)-1,2,4-triazole-3,5-dione." [CAS:13274-75-4, PubChem_Compound:11368000, ChemSpiderID:9542917, PMID:15897015]
synonym: "NPTAD" EXACT []
is_a: XLMOD:09061 ! Cookson type reagent
relationship: has_fluorophore XLMOD:06103 ! 4-nitrophenyl
relationship: has_reactive_group XLMOD:00160 ! TAD

[Term]
id: XLMOD:09067
name: edaravone
def: "Edaravone." [CAS:89-25-8, PubChem_Compound:4021, ChemSpiderID:3881, ChemicalBookNo:CB1287462, PMID:20382108]
synonym: "PMP" EXACT []
synonym: "1-phenyl-3-methyl-5-pyrazolone" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06506 ! carbohydrate reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09068
name: tris(trimethoxyphenyl)phosphonium compound
def: "Tris(trimethoxyphenyl)phosphonium compound." [PMID:11857728]
synonym: "TMPP compound" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09069
name: 1S-pentafluorophenyl tris(2,4,6-trimethoxyphenyl)phosphonium acetate bromide
def: "1S-pentafluorophenyl tris(2,4,6-trimethoxyphenyl)phosphonium acetate bromide." [PMID:12590398]
synonym: "TMPP-AcPFP" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:09068 ! tris(trimethoxyphenyl)phosphonium compound
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09070
name: (4-hydrazino-4-oxobutyl) [tris(2,4,6-trimethoxyphenyl)phosphonium bromide
def: "(4-hydrazino-4-oxobutyl) [tris(2,4,6-trimethoxyphenyl)phosphonium bromide." [PMID:12590398]
synonym: "TMPP-PrG" EXACT []
is_a: XLMOD:09068 ! tris(trimethoxyphenyl)phosphonium compound
relationship: has_reactive_group XLMOD:00159 ! hydrazine
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive

[Term]
id: XLMOD:09071
name: Tris(2,4,6,-trimethoxyphenyl)phosphonium acetic acid
def: "Tris(2,4,6,-trimethoxyphenyl)phosphonium acetic acid." [PMID:19449318]
synonym: "TMPP-AA" EXACT []
synonym: "TMPP-AcCOOH" EXACT []
is_a: XLMOD:09068 ! tris(trimethoxyphenyl)phosphonium compound
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive
relationship: is_reactive_with XLMOD:06516 ! cholesterol reactive

[Term]
id: XLMOD:09072
name: Tris(2,4,6,-trimethoxyphenyl)phosphonium ethanoic acid bromide
def: "Tris(2,4,6,-trimethoxyphenyl)phosphonium ethanoic acid bromide." [PMID:11857728]
synonym: "TMPP-MeCOOH" EXACT []
is_a: XLMOD:09068 ! tris(trimethoxyphenyl)phosphonium compound
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09073
name: Tris(2,4,6,-trimethoxyphenyl)phosphonium propionic acid bromide
def: "Tris(2,4,6,-trimethoxyphenyl)phosphonium propionic acid bromide." [PMID:11857728]
synonym: "TMPP-PrCOOH" EXACT []
is_a: XLMOD:09068 ! tris(trimethoxyphenyl)phosphonium compound
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09074
name: Tris(2,4,6,-trimethoxyphenyl)phosphonium propylamine bromide
def: "Tris(2,4,6,-trimethoxyphenyl)phosphonium propylamine bromide." [PMID:11857728]
synonym: "TMPP-PrNH2" EXACT []
is_a: XLMOD:09068 ! tris(trimethoxyphenyl)phosphonium compound
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09075
name: benzoic anhydride
def: "Benzoic anhydride." [CAS:93-97-0, PubChem_Compound:7167, ChemSpiderID:6899, ChemicalBookNo:CB1260942, PMID:15897015]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00166 ! anhydride

[Term]
id: XLMOD:09076
name: propionic anhydride
def: "Propionic anhydride." [CAS:123-62-6, PubChem_Compound:31263, ChemSpiderID:29003, ChemicalBookNo:CB7852974, PMID:15897015]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00166 ! anhydride

[Term]
id: XLMOD:09077
name: 4-toluenesulfonhydrazide
def: "4-toluenesulfonhydrazide." [CAS:1576-35-8, PubChem_Compound:15303, ChemSpiderID:14566, ChemicalBookNo:CB6156664, PMID:15897015]
synonym: "TSH" EXACT []
synonym: "4-Methylbenzenesulfonhydrazide" EXACT []
synonym: "p-toluenesulfonhydrazide" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:09078
name: 2-(N,N-dimethyl-amino)ethyl acrylate
def: "2-(N,N-dimethyl-amino)ethyl acrylate." [CAS:924-99-2, ChemSpiderID:16195, ChemicalBookNo:CB1468951, PMID:15897015]
synonym: "DMAE acrylate" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09079
name: 1-naphthylisothiocyanate
def: "1-Naphthylisothiocyanate." [CAS:551-06-4, PubChem_Compound:11080, ChemSpiderID:10609, ChemicalBookNo:CB8696418, PMID:15897015]
synonym: "NIT" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00162 ! isothiocyanate

[Term]
id: XLMOD:09080
name: sulfur trioxide pyridine complex
def: "Sulfur trioxide pyridine complex." [CAS:26412-87-3, PubChem_Compound:168533, ChemSpiderID:147422, ChemicalBookNo:CB9284694, PMID:15897015]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive

[Term]
id: XLMOD:09081
name: sulfur trioxide N,N-dimethyl-formamide complex
def: "Sulfur trioxide N,N-dimethyl-formamide complex." [CAS:29584-42-7, PubChem_Compound:169056, ChemicalBookNo:CB0234621, PMID:15897015]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive

[Term]
id: XLMOD:09082
name: 2-Acrylamido-2-methyl-1-propanesulfonic acid
def: "2-acrylamino-2-methyl-propanesulfonic acid." [CAS:15214-89-8, PubChem_Compound:65360, ChemSpiderID:58836, ChemicalBookNo:CB3470952, PMID:15897015]
synonym: "AMDSA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09083
name: benzyl chloride
def: "Benzyl chloride." [CAS:100-44-7, PubChem_Compound:7503, ChemSpiderID:13840690, ChemicalBookNo:CB1852583, PMID:15897015]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00155 ! acyl chloride

[Term]
id: XLMOD:09084
name: acetic anhydride
def: "Acetic anhydride." [CAS:108-24-7, PubChem_Compound:7918, ChemSpiderID:7630, PMID:15897015]
synonym: "Ethanoic anhydride" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00166 ! anhydride

[Term]
id: XLMOD:09085
name: N-methyl-4-hydrazino-7-nitrobenzofurazan
def: "N-methyl-4-hydrazino-7-nitrobenzofurazan." [CAS:214147-22-5, PubChem_Compound:3533602, ChemSpiderID:20171264, ChemicalBookNo:CB0111892, PMID:15897015]
synonym: "MNBDH" EXACT []
synonym: "4-(1-Methylhydrazino)-7-nitrobenzofurazan" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09086
name: boron trifluoride methanol
def: "Boron trifluoride methanol." [CAS:373-57-9, PubChem_Compound:11062313, ChemSpiderID:9237466, ChemicalBookNo:CB1184013, PMID:15897015]
synonym: "BF3-methanol" EXACT []
is_a: XLMOD:06016 ! boron trifluoride reagent

[Term]
id: XLMOD:09088
name: (3-(2-nitro-4-trifluoromethylphenyl)aminophenyl)dihydroxyborane
def: "(3-(2-nitro-4-trifluoromethylphenyl)aminophenyl)dihydroxyborane." [PMID:15897015]
synonym: "2NFP-APB" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive

[Term]
id: XLMOD:09089
name: 2-nitro-4-trifluoromethylphenylhydrazine
def: "2-nitro-4-trifluoromethylphenylhydrazine." [CAS:1513-50-4, PubChem_Compound:3838097, ChemSpiderID:3063768, ChemicalBookNo:CB5751590, PMID:15897015]
synonym: "NFPH" EXACT []
synonym: "2-NFPH" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09090
name: 4-chloro-7-nitro-2,1,3-benzoxadiazole
def: "4-chloro-7-nitro-2,1,3-benzoxadiazole." [CAS:10199-89-0, PubChem_Compound:25043, ChemSpiderID:23406, ChemicalBookNo:CB5173637, PMID:15897015]
synonym: "NBDCl" EXACT []
synonym: "4-Chloro-7-nitrobenzofurazan" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00158 ! halobenzofurazan

[Term]
id: XLMOD:09091
name: NBD-PZ Hydrochloride
def: "NBD-PZ Hydrochloride." [CAS:374730-75-3, PubChem_Compound:71751110, ChemSpiderID:24746629, ChemicalBookNo:CB52558061, PMID:15897015]
synonym: "4-Nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole hydrochloride" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00158 ! halobenzofurazan

[Term]
id: XLMOD:09092
name: sulfanilic acid
def: "Sulfanilic acid." [CAS:121-57-3, PubChem_Compound:8479, ChemSpiderID:8166, ChemicalBookNo:CB1489237, PMID:7756703]
synonym: "4-aminobenzenesulphonic acid" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09093
name: 1-chloro-4-methylpyridinium iodide
def: "1-chloro-4-methylpyridinium iodide." [ChemSpiderID:29321698, PMID:12621624]
synonym: "CMPI" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09094
name: 3-(2,5-dioxopyrrolidin-1-yl-oxycarbonyl)propyl]trimethylammonium chloride
def: "3-(2,5-dioxopyrrolidin-1-yl-oxycarbonyl)propyl]trimethylammonium chloride." [PMID:22575224]
synonym: "TMAB" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09095
name: N-methylnicotinic acid N-hydroxysuccinimide ester
def: "N-methylnicotinic acid N-hydroxysuccinimide ester." [PMID:23524938, PMID:21382752]
synonym: "C1-NA-NHS" EXACT []
is_a: XLMOD:09005 ! NA-NHS ester
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09096
name: deuterium labelled N-methylnicotinic acid N-hydroxysuccinimide ester
def: "Deuterium labelled N-methylnicotinic acid N-hydroxysuccinimide ester." [PMID:23524938, PMID:23628173]
synonym: "C1-NA-NHS-d3" EXACT []
synonym: "C1D3-NA-NHS" EXACT []
is_a: XLMOD:09005 ! NA-NHS ester
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09097
name: N-propylnicotinic acid N-hydroxysuccinimide ester
def: "N-propylnicotinic acid N-hydroxysuccinimide ester." [PMID:23524938]
synonym: "C3-NA-NHS" EXACT []
is_a: XLMOD:09005 ! NA-NHS ester
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive

[Term]
id: XLMOD:09098
name: deuterium labelled N-propylnicotinic acid N-hydroxysuccinimide ester
def: "Deuterium labelled N-propylnicotinic acid N-hydroxysuccinimide ester." [PMID:23524938]
synonym: "C3-NA-NHS-d7" EXACT []
synonym: "C3D7-NA-NHS" EXACT []
is_a: XLMOD:09005 ! NA-NHS ester
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive

[Term]
id: XLMOD:09099
name: N-butylnicotinic acid N-hydroxysuccinimide ester
def: "N-butylnicotinic acid N-hydroxysuccinimide ester." [PMID:23524938]
synonym: "C4-NA-NHS" EXACT []
is_a: XLMOD:09005 ! NA-NHS ester
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive

[Term]
id: XLMOD:09100
name: deuterium labelled N-butylnicotinic acid N-hydroxysuccinimide ester
def: "Deuterium labelled N-butylnicotinic acid N-hydroxysuccinimide ester." [PMID:23524938]
synonym: "C4-NA-NHS-d9" EXACT []
synonym: "C4D9-NA-NHS" EXACT []
is_a: XLMOD:09005 ! NA-NHS ester
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive

[Term]
id: XLMOD:09101
name: 2,4-Dinitrofluorobenzene
def: "2,4-Dinitrofluorobenzene." [CAS:70-34-8, PubChem_Compound:6264, ChemSpiderID:21106037, ChemicalBookNo:CB9442373, PMID:16808485]
synonym: "DNFB" EXACT []
synonym: "FNDB" EXACT []
synonym: "1-Fluoro-2,4-dinitrobenzene" EXACT []
is_a: XLMOD:09243 ! Sanger type reagent
relationship: has_reactive_group XLMOD:00145 ! aryl halide

[Term]
id: XLMOD:09102
name: 4-N,N,N-trimethylammonioanilylN'-hydroxysuccinimidyl carbamate iodide
def: "4-N,N,N-trimethylammonioanilylN'-hydroxysuccinimidyl carbamate iodide." [PMID:22575224]
synonym: "TAHS" EXACT []
synonym: "p-N,N,N-trimethylammonioanilylN'-hydroxysuccinimidyl carbamate iodide" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00164 ! carbamate

[Term]
id: XLMOD:09103
name: deuterium labelled p-N,N,N-trimethylammonioanilylN'-hydroxysuccinimidyl carbamate iodide
def: "Deuterium labelled p-N,N,N-trimethylammonioanilylN'-hydroxysuccinimidyl carbamate iodide." [PMID:22575224]
synonym: "TAHS-d3" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00164 ! carbamate
relationship: is_labelled XLMOD:00010 ! deuterium labelled

[Term]
id: XLMOD:09104
name: 4-methylpiperazine acetyl succinimide
def: "4-methylpiperazine acetyl succinimide." [PMID:22575224]
synonym: "MPAS" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09105
name: deuterium labelled 4-methylpiperazine acetyl succinimide
def: "Deuterium labelled 4-methylpiperazine acetyl succinimide." [PMID:22575224]
synonym: "MPAS-d3" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09106
name: 4-methylpiperadinebutyryl succinimide
def: "4-methylpiperadinebutyryl succinimide." [PMID:22575224]
synonym: "MPBS" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09107
name: deuterium labelled 4-methylpiperadinebutyryl succinimide
def: "Deuterium labelled 4-methylpiperadinebutyryl succinimide." [PMID:22575224]
synonym: "MPBS-d3" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09108
name: dimethylaminobutyryl succinimide
def: "Dimethylaminobutyryl succinimide." [PMID:22575224]
synonym: "DMABS" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09109
name: deuterium labelled dimethylaminobutyryl succinimide
def: "Deuterium labelled dimethylaminobutyryl succinimide." [PMID:22575224]
synonym: "DMABS-d3" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00101 ! NHS ester
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09110
name: 13C-dansyl chloride
def: "13C-dansyl chloride." [PMID:22575224]
synonym: "13C DNS-Cl" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_labelled XLMOD:00036 ! 13C labelled
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive
relationship: is_reactive_with XLMOD:06515 ! nucleoside reactive

[Term]
id: XLMOD:09111
name: pentafluorophenyl-activated ester of polyethyleneglycol
def: "Pentafluorophenyl-activated ester of polyethyleneglycol." [PMID:18954088]
synonym: "PEG-OPFP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00120 ! pentafluorophenyl
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09112
name: 13C labelled pentafluorophenyl-activated ester of polyethyleneglycol
def: "13C labelled pentafluorophenyl-activated ester of polyethyleneglycol." [PMID:18954088]
synonym: "13C-PEG-OPFP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00120 ! pentafluorophenyl
relationship: is_labelled XLMOD:00036 ! 13C labelled
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09113
name: cholamine
def: "Cholamine." [ChemicalBookNo:CB8492922, PMID:22575224]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09114
name: deuterium labelled cholamine
def: "Deuterium labelled cholamine." [PMID:22575224]
synonym: "cholamine-d9" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09115
name: 2-bromo-1-methylpyridinium iodide
def: "2-bromo-1-methylpyridinium iodide." [CAS:52693-56-8, PubChem_Compound:12233907, ChemSpiderID:11554184, ChemicalBookNo:CB13083603, PMID:22575224]
synonym: "BMP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09116
name: deuterium labelled 2-bromo-1-methylpyridinium iodide
def: "Deuterium labelled 2-bromo-1-methylpyridinium iodide." [PMID:22575224]
synonym: "BMP-d3" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09117
name: 3-carbinol-1-methylpyridinium iodide
def: "3-carbinol-1-methylpyridinium iodide." [PMID:22575224]
synonym: "CMP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09118
name: deuterium labelled 3-carbinol-1-methylpyridinium iodide
def: "Deuterium labelled 3-carbinol-1-methylpyridinium iodide." [PMID:22575224]
synonym: "CMP-d3" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09119
name: 4-dimethylaminophenacyl bromide
def: "4-dimethylaminophenacyl bromide." [CAS:37904-72-6, PubChem_Compound:142225, ChemSpiderID:125460, ChemicalBookNo:CB4113692, PMID:22575224]
synonym: "DmPA-Br" EXACT []
synonym: "2-Bromo-1-[4-(dimethylamino)phenyl]ethanone" EXACT []
synonym: "p-dimethylaminophenacyl bromide" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_fluorophore XLMOD:06110 ! phenacyl
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09120
name: 13C labelled p-dimethylaminophenacyl bromide
def: "13C labelled p-dimethylaminophenacyl bromide." [PMID:22575224]
synonym: "13C-DmPA-Br" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_fluorophore XLMOD:06110 ! phenacyl
relationship: is_labelled XLMOD:00036 ! 13C labelled
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09121
name: 7-(N,N-dimethylaminosulfonyl)-4-(aminoethyl)piperadino-2,1-3-benzoxadiazole
def: "7-(N,N-dimethylaminosulfonyl)-4-(aminoethyl)piperadino-2,1-3-benzoxadiazole." [PMID:22575224]
synonym: "DBD-PZ-NH2" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09122
name: deuterium labelled 7-(N,N-dimethylaminosulfonyl)-4-(aminoethyl)piperadino-2,1-3-benzoxadiazole
def: "Deuterium labelled 7-(N,N-dimethylaminosulfonyl)-4-(aminoethyl)piperadino-2,1-3-benzoxadiazole." [PMID:22575224, PMID:16167303]
synonym: "DBD-PZ-NH2-d6" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09123
name: 7-(N,N-dimethylaminosulfonyl)-4-piperadino-2,1-3-benzoxadiazole
def: "7-(N,N-dimethylaminosulfonyl)-4-piperadino-2,1-3-benzoxadiazole." [PMID:22575224]
synonym: "DBD-PZ" EXACT []
synonym: "4-(N,N-dimethylaminosulfonyl)-7-(1-piperazinyl)-2,1,3-benzoxadiazole" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09124
name: deuterium labelled 7-(N,N-dimethylaminosulfonyl)-4-piperadino-2,1-3-benzoxadiazole
def: "Deuterium labelled 7-(N,N-dimethylaminosulfonyl)-4-piperadino-2,1-3-benzoxadiazole." [PMID:22575224]
synonym: "DBD-PZ-d6" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09125
name: deuterium labelled Girard's reagent P
def: "Deuterium labelled pyridinioacetohydrazide chloride." [PMID:22575224]
synonym: "Gir P-d5" EXACT []
synonym: "GP-d5" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: has_reactive_group XLMOD:00110 ! hydrazide
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09126
name: deuterium labelled 2,4-dinitrophenylhydrazine
def: "Deuterium labelled 2,4-dinitrophenylhydrazine." [PMID:22575224]
synonym: "DNPH-d3" EXACT []
synonym: "2,4-Dinitro-3,5,6-trideuterophenylhydrazine" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: has_fluorophore XLMOD:06104 ! 2,4-dinitrophenyl
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09127
name: 2-Phenylenediamine
def: "2-Phenylenediamine." [CAS:95-54-5, PubChem_Compound:7243, ChemSpiderID:13837582, ChemicalBookNo:CB9854699, PMID:21382752]
synonym: "o-Phenylenediamine" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09129
name: 5,5'-Dithio-(bis-2-nitrobenzoic) acid
def: "5,5'-Dithio-(bis-2-nitrobenzoic) acid." [CAS:69-78-3, PubChem_Compound:6254, ChemSpiderID:6018, ChemicalBookNo:CB2215444, PMID:21382752]
synonym: "Ellman's reagent" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09130
name: 4-(Hydroxymercuri)benzoate acid
def: "4-(Hydroxymercuri)benzoate acid." [CAS:138-85-2, PubChem_Compound:23667696, ChemSpiderID:8104477, ChemicalBookNo:CB9350409, PMID:21382752]
synonym: "p-(Hydroxymercuri)benzoate acid" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09131
name: N-Ethylmaleimide
def: "N-Ethylmaleimide." [CAS:128-53-0, PubChem_Compound:4362, ChemSpiderID:4209, ChemicalBookNo:CB5748314, PMID:21382752, PMID:29906677]
synonym: "NEM" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:09132
name: 4-Methylbenzenesulfonyl isocyanate
def: "4-Methylbenzenesulfonyl isocyanate." [CAS:4083-64-1, PubChem_Compound:77703, ChemSpiderID:70104, ChemicalBookNo:CB8256995, PMID:21382752]
synonym: "p-Toluenesulfonyl isocyanate" EXACT []
synonym: "Tosyl isocyanate" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00124 ! isocyanate

[Term]
id: XLMOD:09133
name: 1-(4-lsopropyl) phenyl-3-methyl-5-pyrazolone
def: "1-(4-lsopropyl) phenyl-3-methyl-5-pyrazolone." [PMID:21382752]
synonym: "PMPP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive

[Term]
id: XLMOD:09134
name: 2-Sulfobenzoic anhydride
def: "2-Sulfobenzoic anhydride." [CAS:81-08-3, PubChem_Compound:65729, ChemSpiderID:59152, ChemicalBookNo:CB4286815, PMID:21382752]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00166 ! anhydride

[Term]
id: XLMOD:09135
name: 1-pyrenesulfonyl chloride
def: "1-pyrenesulfonyl chloride." [CAS:61494-52-8, PubChem_Compound:2762670, ChemSpiderID:2043373, ChemicalBookNo:CB0708281, PMID:21382752]
synonym: "PSC" EXACT []
synonym: "Pyrene-1-sulfonyl chloride" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00156 ! sulfonyl chloride

[Term]
id: XLMOD:09136
name: 2,3-Naphthalenedialdehyde
def: "2,3-Naphthalenedialdehyde." [CAS:7149-49-7, PubChem_Compound:96400, ChemSpiderID:87023, ChemicalBookNo:CB5283316, PMID:21382752]
synonym: "Naphthalene-2,3-dicarbaldehyde" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09137
name: 3-chlorocarbonyl-6,7-dimethoxy-1-methyl-2(1H)-quinoxalinone
def: "3-chlorocarbonyl-6,7-dimethoxy-1-methyl-2(1H)-quinoxalinone." [CAS:104077-15-8, PubChem_Compound:147056, ChemSpiderID:129681, ChemicalBookNo:CB6511517, PMID:21382752]
synonym: "DMEQ-COCI" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09138
name: Fluorescein-5-isothiocyanate
def: "Fluorescein-5-isothiocyanate." [CAS:3326-32-7, PubChem_Compound:18730, ChemSpiderID:17686, ChemicalBookNo:CB0173162, PMID:21382752]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00162 ! isothiocyanate

[Term]
id: XLMOD:09139
name: 2-Chloro-1-methylpyridinium
def: "2-Chloro-1-methylpyridinium." [CAS:45528-84-5, PubChem_Compound:167070, ChemSpiderID:146180, ChemicalBookNo:CB11376592, PMID:21382752]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09140
name: (5-N-succinimidoxy-5-oxopentyl)triphenylphosphonium bromide
def: "(5-N-succinimidoxy-5-oxopentyl)triphenylphosphonium bromide." [PMID:21382752]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09141
name: Diethylethoxymethylenemalonate
def: "Diethylethoxymethylenemalonate." [CAS:87-13-8, PubChem_Compound:6871, ChemSpiderID:6609, ChemicalBookNo:CB3163908, PMID:21382752, PMID:22889992]
synonym: "DEEMM" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09142
name: 4-(dimethylamino)phenyl isothiocyanate
def: "4-(dimethylamino)phenyl isothiocyanate." [CAS:2131-64-8, PubChem_Compound:75047, ChemSpiderID:67599, ChemicalBookNo:CB6742874, PMID:21382752]
synonym: "DMAP-NCS" EXACT []
synonym: "p-Dimethylaminophenyl isothiocyanate" EXACT []
synonym: "p-Isothiocyanato-N,N-dimethylaniline" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00162 ! isothiocyanate

[Term]
id: XLMOD:09143
name: 3-Nitrophenyl isothiocyanate
def: "3-Nitrophenyl isothiocyanate." [CAS:3529-82-6, PubChem_Compound:19050, ChemSpiderID:17985, ChemicalBookNo:CB5235618, PMID:21382752]
synonym: "m-Nitrophenyl isothiocyanate" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00162 ! isothiocyanate

[Term]
id: XLMOD:09144
name: 3-aminopyridyl-N-hydroxysuccinimidylcarbamate
def: "3-aminopyridyl-N-hydroxysuccinimidylcarbamate." [PMID:21382752]
synonym: "APDS" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00164 ! carbamate

[Term]
id: XLMOD:09145
name: N-(4-aminomethylphenyl)pyridinium
def: "N-(4-aminomethylphenyl)pyridinium." [PMID:21382752]
synonym: "AMPP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09146
name: Cyclohexanedione
def: "Cyclohexanedione." [CAS:765-87-7, PubChem_Compound:13006, ChemSpiderID:12465, ChemicalBookNo:CB7854271, PMID:26496130]
synonym: "CHD" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09148
name: 2-fluoro-1-methylpyridium
def: "2-fluoro-1-methylpyridium." [PMID:26496130, PMID:26454158]
synonym: "2-FMP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00032 ! hydroxyl reactive
relationship: is_reactive_with XLMOD:06509 ! phenol reactive

[Term]
id: XLMOD:09149
name: triplex 5-diethylaminonaphthalene-1-sulfonyl chloride
def: "Triplex 5-diethylaminonaphthalene-1-sulfonyl chloride." [PMID:26496130]
synonym: "DensCl" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00156 ! sulfonyl chloride

[Term]
id: XLMOD:09150
name: N-(5-fluoro-2,4-dinitrophenyl)-D-leucinamide
def: "N-(5-fluoro-2,4-dinitrophenyl)-D-leucinamide." [PMID:26496130]
synonym: "D-FDLA" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:09244 ! Marfey type reagent
relationship: has_fluorophore XLMOD:06104 ! 2,4-dinitrophenyl

[Term]
id: XLMOD:09152
name: ebselen
def: "Ebselen." [CAS:60940-34-3, PubChem_Compound:3194, ChemSpiderID:3082, ChemicalBookNo:CB5301009, PMID:26496130]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09153
name: iodoacetamide
def: "Iodoacetamide." [CAS:144-48-9, PubChem_Compound:3727, ChemSpiderID:3596, ChemicalBookNo:CB4760867, PMID:26496130]
synonym: "IAM" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09154
name: isopropylchloroformate
def: "Isopropylchloroformate." [CAS:108-23-6, PubChem_Compound:7917, ChemSpiderID:7629, ChemicalBookNo:CB5702693, PMID:26496130]
synonym: "IPCF" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:09155
name: 2-Nitrobenzaldehyde
def: "2-Nitrobenzaldehyde." [CAS:552-89-6, PubChem_Compound:11101, ChemSpiderID:10630, ChemicalBookNo:CB8414184, PMID:26496130]
synonym: "2-NB" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09157
name: 5-N-succinimidoxy-5-oxopentyl)triphenylphosphonium bromide
def: "5-N-succinimidoxy-5-oxopentyl)triphenylphosphonium bromide." [PMID:22889992]
synonym: "SPTPP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09158
name: 2,5-dioxopyrrolidin-1-yl N-tri(pyrrolidino)phosphoranylideneamino carbamate
def: "2,5-dioxopyrrolidin-1-yl N-tri(pyrrolidino)phosphoranylideneamino carbamate." [PMID:22889992]
synonym: "FOSF" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00164 ! carbamate

[Term]
id: XLMOD:09159
name: 2-nitrophenylhydrazine hydrochloride
def: "2-nitrophenylhydrazine hydrochloride." [CAS:56413-75-3, PubChem_Compound:5743520, ChemSpiderID:21306, ChemicalBookNo:CB5875432, PMID:3429573, PMID:10905720]
synonym: "2-NPH-HCl" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09161
name: phenacyl bromide
def: "Phenacyl bromide." [CAS:70-11-1, PubChem_Compound:6259, ChemSpiderID:6023, ChemicalBookNo:CB6305185, PMID:3394930]
synonym: "2-Bromoacetophenone" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_fluorophore XLMOD:06110 ! phenacyl
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09163
name: 2-(4-nitro-benzyl)-N,N'-diisopropyl-iso-urea
def: "2-(4-nitro-benzyl)-N,N'-diisopropyl-iso-urea." [PMID:3394930]
synonym: "o-(4-nitro-benzyl)-N,N'-diisopropyl-iso-urea" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09164
name: 3-nitrophenylhydrazine
def: "3-nitrophenylhydrazine." [PMID:23580203]
synonym: "3-NPH" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09165
name: butyl 1-(pyridin-4-yl) piperidine 4-carboxylate
def: "Butyl 1-(pyridin-4-yl) piperidine 4-carboxylate." [PMID:23245244]
synonym: "BPPC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09166
name: 4-bromo-N-methylbenzylamine
def: "4-bromo-N-methylbenzylamine." [CAS:699-03-6, PubChem_Compound:485400, ChemSpiderID:425634, ChemicalBookNo:CB3478655, PMID:29213145]
synonym: "4-BNMA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00133 ! amine reactive group

[Term]
id: XLMOD:09167
name: N-methyl-2-phenylethanamine
def: "N-methyl-2-phenylethanamine." [CAS:589-08-2, PubChem_Compound:11503, ChemSpiderID:11019, ChemicalBookNo:CB6140245, PMID:29213145]
synonym: "MPEA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09168
name: benzoyl chloride
def: "Benzoyl chloride." [CAS:98-88-4, PubChem_Compound:7412, ChemSpiderID:7134, ChemicalBookNo:CB8854753, PMID:28660399]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00155 ! acyl chloride

[Term]
id: XLMOD:09169
name: N-tert-butylmaleimide
def: "N-tert-butylmaleimide." [CAS:4144-22-3, PubChem_Compound:643190, ChemSpiderID:558357, ChemicalBookNo:CB4720254, PMID:29906677]
synonym: "NrBM" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:09170
name: N-propylmaleimide
def: "N-propylmaleimide." [CAS:21746-40-7, PubChem_Compound:89033, ChemSpiderID:80338, ChemicalBookNo:CB9737837, PMID:29906677]
synonym: "NPM" EXACT []
synonym: "1-Propylpyrrole-2,5-dione" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:09171
name: 4-hydrazinobenzoic acid
def: "4-hydrazinobenzoic acid." [CAS:619-67-0, PubChem_Compound:12089, ChemSpiderID:11592, ChemicalBookNo:CB5271632, PMID:29853022]
synonym: "HBA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09172
name: 2-aminoethanethiol
def: "2-aminoethanethiol." [CAS:60-23-1, PubChem_Compound:6058, ChemSpiderID:5834, ChemicalBookNo:CB2223766, PMID:29853022]
synonym: "Cysteamine" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09173
name: 2-diphenylacetyl-1,3-indandione-1-hydrazone
def: "2-diphenylacetyl-1,3-indandione-1-hydrazone." [CAS:5102-79-4, PubChem_Compound:5375071, ChemicalBookNo:CB4455145, PMID:29853022]
synonym: "DAIH" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09174
name: 3-methylbenzothiazolin-2-one hydrazone
def: "3-methylbenzothiazolin-2-one hydrazone." [CAS:1128-67-2, PubChem_Compound:5359575, ChemSpiderID:4700314, ChemicalBookNo:CB2663986, PMID:29853022]
synonym: "MBTH" EXACT []
synonym: "(3-Methyl-1,3-benzothiazol-2-ylidene)hydrazine" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09175
name: cyclohexane-1,3-dione
def: "Cyclohexane-1,3-dione." [CAS:504-02-9, PubChem_Compound:10434, ChemSpiderID:10004, ChemicalBookNo:CB8319650, PMID:29853022]
synonym: "Dihydroresorcinol" EXACT []
synonym: "1,3-Cyclohexanedione" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09176
name: pyroglutamic acid succinimidyl ester
def: "Pyroglutamic acid succinimidyl ester." [PMID:27582321]
synonym: "PGA-OSu" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09177
name: 2,4,6-trichlorophenylhydrazine
def: "2,4,6-trichlorophenylhydrazine." [CAS:5329-12-4, PubChem_Compound:79234, ChemSpiderID:71559, ChemicalBookNo:CB4690892, PMID:29853022]
synonym: "2,4,6-Trichlorophenylhydrazine" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09178
name: O-2,3,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride
def: "O-2,3,4,5,6-(pentafluorobenzyl) hydroxylamine hydrochloride." [CAS:57981-02-9, PubChem_Compound:122307, ChemSpiderID:109062, ChemicalBookNo:CB8307815, PMID:29853022]
synonym: "PFBO" EXACT []
synonym: "Florox Reagent" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09179
name: benzoyl hydrazine
def: "Benzoyl hydrazine." [CAS:613-94-5, PubChem_Compound:11955, ChemSpiderID:11461, ChemicalBookNo:CB2760863, PMID:29853022]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09180
name: 2-Iodoacetanilide
def: "2-Iodoacetanilide." [CAS:19591-17-4, PubChem_Compound:140559, ChemSpiderID:123972, ChemicalBookNo:CB2169857, PMID:29650481]
synonym: "2-IAN" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09181
name: N-hydroxy-benzotriazolyl-(S)-naproxen ester
def: "N-hydroxy-benzotriazolyl-(S)-naproxen ester." [PMID:29601646]
synonym: "Npx-ester" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06517 ! histamine reactive

[Term]
id: XLMOD:09182
name: methyl acetimidate
def: "Methyl acetimidate." [CAS:14777-29-8, PubChem_Compound:26888, ChemSpiderID:10652948, ChemicalBookNo:CB1506534, PMID:23628173]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09183
name: 13C labelled methyl acetimidate
def: "13C labelled methyl acetimidate." [PMID:23628173]
synonym: "13C-methyl acetimidate" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_labelled XLMOD:00036 ! 13C labelled
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09184
name: 13C labelled formaldehyde
def: "13C labelled formaldehyde reagent." [PMID:23628173]
synonym: "13C-formaldehyde" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_labelled XLMOD:00036 ! 13C labelled
relationship: has_reactive_group XLMOD:00116 ! aldehyde
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09185
name: acetaldehyde
def: "Acetaldehyde." [CAS:75-07-0, PubChem_Compound:177, ChemSpiderID:172, ChemicalBookNo:CB8175809, PMID:23628173]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09186
name: deuterium labelled acetaldehyde
def: "Deuterium labelled acetaldehyde." [PMID:23628173]
synonym: "acetaldehyde-d4" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09187
name: 4-(4-methyl-1-piperazyl)-3-nitrobenzoyl azide
def: "4-(4-methyl-1-piperazyl)-3-nitrobenzoyl azide." [PMID:23628173]
synonym: "APZ" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09188
name: dibenzyl ethoxymethylene malonate
def: "Dibenzyl ethoxymethylene malonate." [ChemSpiderID:48244742, PMID:26477276]
synonym: "DBEMM" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09189
name: benzyl ethyl ethoxymethylene malonate
def: "Benzyl ethyl ethoxymethylene malonate." [PMID:26477276]
synonym: "EBEMM" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09190
name: diisopropyl hydrogen phosphite
def: "Diisopropyl hydrogen phosphite." [CAS:1809-20-7, PubChem_Compound:558181, ChemSpiderID:485223, ChemicalBookNo:CB5671052, PMID:26477276]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09191
name: 2-(2-[7H-dibenzo (a,g)carbazol-7-yl]-ethoxy)ethyl chloroformate
def: "2-(2-[7H-dibenzo (a,g)carbazol-7-yl]-ethoxy)ethyl chloroformate." [PMID:26477276]
synonym: "DBCEC" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:09192
name: ethyl chloroformate
def: "Ethyl chloroformate." [CAS:541-41-3, PubChem_Compound:10928, ChemSpiderID:10465, PMID:26477276]
synonym: "ECF" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:09193
name: 1-bromobutane
def: "1-bromobutane." [CAS:109-65-9, PubChem_Compound:8002, ChemSpiderID:7711, ChemicalBookNo:CB2852782, PMID:26477276]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09194
name: 2-bromopyridine-5-boronic acid
def: "2-bromopyridine-5-boronic acid." [CAS:223463-14-7, PubChem_Compound:2762706, ChemSpiderID:2043406, ChemicalBookNo:CB4371649, PMID:26477276]
synonym: "BPBA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00161 ! boronic acid
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09195
name: (3-dimethylaminophenyl)dihydroxyborane
def: "(3-dimethylaminophenyl)dihydroxyborane." [CAS:178752-79-9, PubChem_Compound:2762527, ChemSpiderID:2043244, ChemicalBookNo:CB1220410, PMID:26477276]
synonym: "DAPB" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09196
name: 1-methylimidazole-2-sulfonyl chloride
def: "1-methylimidazole-2-sulfonyl chloride." [CAS:55694-81-0, PubChem_Compound:11658383, ChemSpiderID:9833118, ChemicalBookNo:CB22592929, PMID:26477276]
synonym: "MLDS" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00156 ! sulfonyl chloride
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09198
name: N-methyl pyridinium-3-sulfonyl chloride
def: "N-methyl pyridinium-3-sulfonyl chloride." [PMID:26477276]
synonym: "NMPS" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00156 ! sulfonyl chloride
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09199
name: quaternary aminooxy reagent
def: "Quaternary aminooxy reagent." [PMID:26477276]
synonym: "QAO" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09200
name: 2,4-dimethoxy-6-piperazin-1-yl pyrimidine
def: "2,4-dimethoxy-6-piperazin-1-yl pyrimidine." [CAS:38539-75-2, PubChem_Compound:18423149, ChemSpiderID:13408232, ChemicalBookNo:CB93096577, PMID:26477276]
synonym: "DMPP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09201
name: 3-pyridylcarbinol
def: "3-pyridylcarbinol." [CAS:100-55-0, PubChem_Compound:7510, ChemSpiderID:7229, ChemicalBookNo:CB6384809, PMID:26477276]
synonym: "3-PC" EXACT []
synonym: "Nicotinyl Alcohol" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09202
name: phenylhydrazine
def: "Phenylhydrazine." [CAS:100-63-0, PubChem_Compound:7516, ChemSpiderID:7235, ChemicalBookNo:CB9216819, PMID:26477276]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine
relationship: is_reactive_with XLMOD:06519 ! alpha-keto acid reactive

[Term]
id: XLMOD:09203
name: o-benzylhydroxylamine
def: "O-benzylhydroxylamine." [CAS:622-33-3, PubChem_Compound:102313, ChemSpiderID:92425, ChemicalBookNo:CB6853994, PMID:26477276]
synonym: "O-BHA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06519 ! alpha-keto acid reactive

[Term]
id: XLMOD:09204
name: o-phenylenediamine
def: "O-phenylenediamine." [CAS:95-54-5, PubChem_Compound:7243, ChemSpiderID:13837582, ChemicalBookNo:CB9854699, PMID:26477276]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06519 ! alpha-keto acid reactive

[Term]
id: XLMOD:09205
name: benzyl alcohol
def: "Benzyl alcohol." [CAS:100-51-6, PubChem_Compound:244, ChemSpiderID:13860335, ChemicalBookNo:CB3852587, PMID:26477276]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06520 ! citric acid reactive

[Term]
id: XLMOD:09206
name: 4-hydroxymercuribenzoate
def: "4-hydroxymercuribenzoate." [PubChem_Compound:3647458, ChemSpiderID:15605527, PMID:26477276]
synonym: "PHMB" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09207
name: 4-chloro-3,5-dinitrobenzotrifluoride
def: "4-chloro-3,5-dinitrobenzotrifluoride." [CAS:393-75-9, PubChem_Compound:9809, ChemSpiderID:9426, ChemicalBookNo:CB1329205, PMID:26477276]
synonym: "CNBF" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09208
name: omega-bromoacetonylquinolinium bromide
def: "Omega-bromoacetonylquinolinium bromide." [PMID:26477276]
synonym: "BQB" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09209
name: pentafluorophenylhydrazine
def: "Pentafluorophenylhydrazine." [CAS:828-73-9, PubChem_Compound:13236, ChemSpiderID:12681, ChemicalBookNo:CB4730404, PMID:26477276]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09210
name: 7-(diethylamino)coumarin-3-carbohydrazide
def: "7-(diethylamino)coumarin-3-carbohydrazide." [CAS:100343-98-4, PubChem_Compound:127564, ChemSpiderID:113172, ChemicalBookNo:CB0751313, PMID:26477276]
synonym: "CHH" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00110 ! hydrazide

[Term]
id: XLMOD:09211
name: L-Carnosine
def: "L-Carnosine." [CAS:305-84-0, PubChem_Compound:439224, ChemSpiderID:388363, ChemicalBookNo:CB0433763, PMID:26477276]
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09212
name: 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate
def: "7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate." [CAS:84806-27-9, PubChem_Compound:2737780, ChemSpiderID:108691, ChemicalBookNo:CB0175393, PMID:27582321]
synonym: "SBD-F" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00165 ! sulfonate
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09213
name: 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole
def: "4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole." [CAS:91366-65-3, PubChem_Compound:122067, ChemSpiderID:108876, ChemicalBookNo:CB4102238, PMID:27582321]
synonym: "ABD-F" EXACT []
synonym: "7-Fluoro-2,1,3-benzoxadiazole-4-sulfonamide" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00158 ! halobenzofurazan
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09214
name: 4-nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole
def: "4-nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole." [CAS:139332-66-4, PubChem_Compound:10586684, ChemSpiderID:8762060, ChemicalBookNo:CB1744464, PMID:27582321]
synonym: "NBD-PZ" EXACT []
synonym: "4-nitro-7-piperazino-2,1,3-benzoxadiazole" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09215
name: 4-(aminosulfonyl)-7-(1-piperazinyl)-2,1,3-benzoxadiazole
def: "4-(aminosulfonyl)-7-(1-piperazinyl)-2,1,3-benzoxadiazole." [ChemSpiderID:32684168, PMID:27582321]
synonym: "ABD-PZ" EXACT []
synonym: "7-(1-Piperazinyl)-2,1,3-benzoxadiazole-4-sulfonamide" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09216
name: 4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole
def: "4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole." [ChemSpiderID:3315424, PMID:27582321]
synonym: "DBD-PyNCS" EXACT []
synonym: "7-(3-Isothiocyanato-1-pyrrolidinyl)-N,N-dimethyl-2,1,3-benzoxadiazole-4-sulfonamide" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09217
name: 4-(N,N-dimethylaminosulfonyl)-7-(2-carboxylpyrrolidine-1-yl)-2,1,3-benzoxadiazole
def: "4-(N,N-dimethylaminosulfonyl)-7-(2-carboxylpyrrolidine-1-yl)-2,1,3-benzoxadiazole." [PMID:27582321]
synonym: "DBD-Pro" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09218
name: 4-(N,N-dimethylaminosulfonyl)-7-(2-chroloformylpyrrolidine-1-yl)-2,1,3-benzoxadiazole
def: "4-(N,N-dimethylaminosulfonyl)-7-(2-chroloformylpyrrolidine-1-yl)-2,1,3-benzoxadiazole." [PubChem_Compound:192501, PMID:27582321]
synonym: "DBD-ProCOCl" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00158 ! halobenzofurazan

[Term]
id: XLMOD:09219
name: 4-nitro-7-(2-chroloformylpyrrolidine-1-yl)-2,1,3-benzoxadiazole
def: "4-nitro-7-(2-chroloformylpyrrolidine-1-yl)-2,1,3-benzoxadiazole." [PMID:27582321]
synonym: "NBD-ProCOCl" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00158 ! halobenzofurazan

[Term]
id: XLMOD:09220
name: 4-(2-carbazoylpyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole
def: "4-(2-carbazoylpyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole." [PMID:27582321]
synonym: "DBD-ProCZ" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09221
name: 4-(2-carbazoylpyrrolidin-1-yl)-7-nitro-2,1,3-benzoxadiazole
def: "4-(2-carbazoylpyrrolidin-1-yl)-7-nitro-2,1,3-benzoxadiazole." [PMID:27582321]
synonym: "NBD-ProCZ" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09222
name: 4-(N,N-dimethylaminosulfonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole
def: "4-(N,N-dimethylaminosulfonyl)-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole." [ChemSpiderID:4320363, PMID:27582321, PMID:22761132]
synonym: "DBD-APy" EXACT []
synonym: "7-(3-Amino-1-pyrrolidinyl)-N,N-dimethyl-2,1,3-benzoxadiazole-4-sulfonamide" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09223
name: 4-nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole
def: "4-nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole." [ChemSpiderID:3633688, PMID:27582321]
synonym: "NBD-APy" EXACT []
synonym: "1-(7-Nitro-2,1,3-benzoxadiazol-4-yl)-3-pyrrolidinamine" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09224
name: 1-(3-Aminopropyl)-3-bromoquinolinium bromide
def: "1-(3-Aminopropyl)-3-bromoquinolinium bromide." [PMID:27582321]
synonym: "APBQ" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09225
name: (S)-1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-3-amine
def: "(S)-1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-3-amine." [PMID:27582321, PMID:26526912]
synonym: "DMT-3(S)-Apy" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09226
name: (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl) pyrrolidine-2-carboxylate
def: "(S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl) pyrrolidine-2-carboxylate." [PMID:27582321, PMID:26526912]
synonym: "DMT-(S)-Pro-OSu" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! amino reactice
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09227
name: (R)-1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-3-amine
def: "(R)-1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)pyrrolidin-3-amine." [PMID:26526912]
synonym: "DMT-3(R)-Apy" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09228
name: (R)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl) pyrrolidine-2-carboxylate
def: "(R)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl) pyrrolidine-2-carboxylate." [PMID:26526912]
synonym: "DMT-(R)-Pro-OSu" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! amino reactice
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09229
name: (S)-4,6-dimethoxy-N-(pyrrolidin-3-yl)-1,3,5-triazin-2-amine
def: "(S)-4,6-dimethoxy-N-(pyrrolidin-3-yl)-1,3,5-triazin-2-amine." [PMID:25366977]
synonym: "DMT-1(S)-Apy" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09230
name: (R)-4,6-dimethoxy-N-(pyrrolidin-3-yl)-1,3,5-triazin-2-amine
def: "(R)-4,6-dimethoxy-N-(pyrrolidin-3-yl)-1,3,5-triazin-2-amine." [PMID:25366977]
synonym: "DMT-1(R)-Apy" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09231
name: 4-Methyl-1,2,4-triazole-3,5-dione
def: "4-Methyl-1,2,4-triazole-3,5-dione." [ChemSpiderID:114186, PMID:27511712]
synonym: "MTAD" EXACT []
synonym: "4-Methyl-TAD" EXACT []
is_a: XLMOD:09061 ! Cookson type reagent
relationship: has_reactive_group XLMOD:00160 ! TAD

[Term]
id: XLMOD:09232
name: 4-(4-dimethylaminophenyl)-1,2,4-triazole-3,5-dione
def: "4-(4-dimethylaminophenyl)-1,2,4-triazole-3,5-dione." [ChemSpiderID:28468701, PMID:27511712]
synonym: "DMAPTAD" EXACT []
is_a: XLMOD:09061 ! Cookson type reagent
relationship: has_reactive_group XLMOD:00160 ! TAD

[Term]
id: XLMOD:09233
name: deuterium labelled 4-(4-dimethylaminophenyl)-1,2,4-triazole-3,5-dione
def: "Deuterium labelled 4-(4-dimethylaminophenyl)-1,2,4-triazole-3,5-dione." [ChemSpiderID:28468701, PMID:27511712]
synonym: "DMAPTAD-d4" EXACT []
is_a: XLMOD:09061 ! Cookson type reagent
relationship: has_reactive_group XLMOD:00160 ! TAD

[Term]
id: XLMOD:09234
name: 4-(4-diethylaminophenyl)-1,2,4-triazole-3,5-dione
def: "4-(4-diethylaminophenyl)-1,2,4-triazole-3,5-dione." [PMID:27511712]
synonym: "DEAPTAD" EXACT []
is_a: XLMOD:09061 ! Cookson type reagent
relationship: is_labelled XLMOD:00010 ! deuterium labelled
relationship: has_reactive_group XLMOD:00160 ! TAD

[Term]
id: XLMOD:09235
name: 2-hydrazino-4-trifluoromethylpyrimidine
def: "2-hydrazino-4-trifluoromethylpyrimidine." [CAS:197305-97-8, ChemSpiderID:1064766, ChemicalBookNo:CB7444959, PubChem_Compound:1268079, PMID:26454158]
synonym: "HTP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09236
name: N-methyl-nicotinic acid N-hydroxysuccinimide ester
def: "N-methyl-nicotinic acid N-hydroxysuccinimide ester." [PMID:26454158]
synonym: "MNAHS" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09237
name: o-(3-trimethylammoniumpropyl)hydroxylamine
def: "O-(3-trimethylammoniumpropyl)hydroxylamine." [PMID:26454158]
synonym: "TMAPH" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09238
name: methoxylamine
def: "Methoxylamine." [CAS:67-62-9, PubChem_Compound:4113, ChemSpiderID:3970, ChemicalBookNo:CB4931737, PMID:26454158]
synonym: "OMHA" EXACT []
synonym: "methoxyamine" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: has_reactive_group XLMOD:00133 ! amine reactive group
relationship: is_reactive_with XLMOD:06510 ! ketone reactive
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09239
name: acetyl chloride
def: "Acetyl chloride." [CAS:75-36-5, PubChem_Compound:6367, ChemSpiderID:6127, ChemicalBookNo:CB4485487, PMID:16458590]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00155 ! acyl chloride

[Term]
id: XLMOD:09240
name: 2,4-dinitrobenzoyl chloride
def: "2,4-dinitrobenzoyl chloride." [CAS:20195-22-6, PubChem_Compound:88401, ChemSpiderID:79755, ChemicalBookNo:CB6933038, PMID:17765276]
synonym: "DNBC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00155 ! acyl chloride

[Term]
id: XLMOD:09241
name: 4-[2-(N,Ndimethylamino)ethylaminosulfonyl]-7-chloro-2,1,3-benzoxadiazole
def: "4-[2-(N,Ndimethylamino)ethylaminosulfonyl]-7-chloro-2,1,3-benzoxadiazole." [CAS:664985-43-7, PubChem_Compound:44629802, ChemSpiderID:24589237, ChemicalBookNo:CB9423743, PMID:17590866]
synonym: "DAABD-Cl" EXACT []
synonym: "7-Chloro-N-[2-(dimethylamino)ethyl]-2,1,3-benzoxadiazole-4-sulfonamide" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09242
name: 4-nitrobenzenesulfonyl chloride
def: "4-nitrobenzenesulfonyl chloride." [CAS:98-74-8, PubChem_Compound:7404, ChemSpiderID:7126, ChemicalBookNo:CB7298161, PMID:16609843]
synonym: "4-NBSC" EXACT []
synonym: "Nosyl chloride" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00156 ! sulfonyl chloride

[Term]
id: XLMOD:09243
name: Sanger type reagent
def: "A LC-MS derivatization reagent containing a fluoro-dinitrobenzene structure." [PSI:XL]
synonym: "Sanger's reagent" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00145 ! aryl halide
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06500 ! secondary amine reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09244
name: Marfey type reagent
def: "A LC-MS derivatization reagent containing a fluoro-dinitrophenyl structure." [PSI:XL]
synonym: "Marfey's reagent" EXACT []
synonym: "MR" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00013 ! membrane permeable
relationship: has_reactive_group XLMOD:00145 ! aryl halide
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06500 ! secondary amine reactive
relationship: is_reactive_with XLMOD:06503 ! amino acid reactive

[Term]
id: XLMOD:09245
name: N-(2,4-dinitro-5-fluorophenyl)-L-alaninamide
def: "N-(2,4-dinitro-5-fluorophenyl)-L-alaninamide." [CAS:95713-52-3, PubChem_Compound:5486955, ChemSpiderID:4589152, ChemicalBookNo:CB5413540]
synonym: "L-FDAA" EXACT []
synonym: "1-Fluoro-2,4-dinitrophenyl-5-L-alanine amide" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:09244 ! Marfey type reagent
relationship: has_fluorophore XLMOD:06104 ! 2,4-dinitrophenyl
relationship: has_reactive_group XLMOD:00145 ! aryl halide

[Term]
id: XLMOD:09246
name: N-(2,4-dinitro-5-fluorophenyl)-D-alaninamide
def: "N-(2,4-dinitro-5-fluorophenyl)-D-alaninamide." [CAS:95713-52-3, PubChem_Compound:5486955, ChemSpiderID:4589152, ChemicalBookNo:CB5413540]
synonym: "D-FDAA" EXACT []
synonym: "1-Fluoro-2,4-dinitrophenyl-5-D-alanine amide" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:09244 ! Marfey type reagent
relationship: has_fluorophore XLMOD:06104 ! 2,4-dinitrophenyl
relationship: has_reactive_group XLMOD:00145 ! aryl halide

[Term]
id: XLMOD:09247
name: N-(5-fluoro-2,4-dinitrophenyl)-L-leucinamide
def: "N-(5-fluoro-2,4-dinitrophenyl)-L-leucinamide." [PMID:26496130]
synonym: "L-FDLA" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:09244 ! Marfey type reagent
relationship: has_fluorophore XLMOD:06104 ! 2,4-dinitrophenyl
relationship: has_reactive_group XLMOD:00145 ! aryl halide

[Term]
id: XLMOD:09248
name: hexyl chloroformate
def: "Hexyl chloroformate." [CAS:6092-54-2, PubChem_Compound:22466, ChemSpiderID:21071, ChemicalBookNo:CB2782111]
synonym: "HCF" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:09249
name: 1,2-Benzo-3,4-dihydrocarbazole-9-ethyl chloroformate
def: "1,2-Benzo-3,4-dihydrocarbazole-9-ethyl chloroformate." [PMID:18970343]
synonym: "BCEOC" EXACT []
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:09250
name: (-)-1-(9-fluorenyl)-ethyl chloroformate
def: "(-)-1-(9-fluorenyl)-ethyl chloroformate." [PMID:25082527]
synonym: "-FLEC" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:09251
name: (+)-1-(9-fluorenyl)-ethyl chloroformate
def: "(+)-1-(9-fluorenyl)-ethyl chloroformate." [PMID:29785784]
synonym: "+FLEC" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06018 ! chloroformate reagent

[Term]
id: XLMOD:09252
name: 1,2-Benzo-3,4-dihydrocarbazole-9-ethyl-benzenesulfonate
def: "1,2-Benzo-3,4-dihydrocarbazole-9-ethyl-benzenesulfonate." [PMID:19525080, PMID:17305246]
synonym: "BDEBS" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00165 ! sulfonate
relationship: is_reactive_with XLMOD:06524 ! bile acid reactive

[Term]
id: XLMOD:09253
name: 2-(2,3-Naphthalimino)ethyl trifluoromethanesulfonate
def: "2-(2,3-Naphthalimino)ethyl trifluoromethanesulfonate." [CAS:128651-50-3, ChemSpiderID:11563131, ChemicalBookNo:CB7667550_EN, DOI:10.2116/bunsekikagaku.53.161]
synonym: "NE-OTf" EXACT []
synonym: "2-(2,3-Naphthalimino)ethyl trifluoromethanesulphonate" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00165 ! sulfonate

[Term]
id: XLMOD:09254
name: 4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-N-piperazino-2,1,3-benzoxadiazole
def: "4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-N-piperazino-2,1,3-benzoxadiazole." [PMID:17590866]
synonym: "DAABD-PZ" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09255
name: 4-[4-carbazoylpiperidin-1-yl]-7-[2-(N,N-dimethylamino)ethylaminosulfonyl]-2,1,3-benzoxadiazole
def: "4-[4-carbazoylpiperidin-1-yl]-7-[2-(N,N-dimethylamino)ethylaminosulfonyl]-2,1,3-benzoxadiazole." [PMID:17590866]
synonym: "DAABD-PiCZ" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09256
name: 4-[2-carbazoylpyrrolidin-1-yl]-7-[2-(N,N-dimethylamino)ethylaminosulfonyl]-2,1,3-benzoxadiazole
def: "4-[2-carbazoylpyrrolidin-1-yl]-7-[2-(N,N-dimethylamino)ethylaminosulfonyl]-2,1,3-benzoxadiazole." [PMID:17590866]
synonym: "DAABD-ProCZ" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09257
name: 4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole
def: "4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole." [PMID:17590866]
synonym: "DAABD-APy" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09258
name: 4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-N-methylhydrazino-2,1,3-benzoxadiazole
def: "4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-N-methylhydrazino-2,1,3-benzoxadiazole." [PMID:17703478]
synonym: "DAABD-MHz" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09259
name: 4-[2-(N,N-dimethylamino) ethylaminosulfonyl]-7-(2-aminobutylamino)-2,1,3-benzoxadiazole
def: "4-[2-(N,N-dimethylamino) ethylaminosulfonyl]-7-(2-aminobutylamino)-2,1,3-benzoxadiazole." [PMID:17703478]
synonym: "DAABD-AB" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09260
name: 4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-(2-aminopentylamino)-2,1,3-benzoxadiazole
def: "4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-(2-aminopentylamino)-2,1,3-benzoxadiazole." [PMID:17703478]
synonym: "DAABD-AP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09261
name: [4-(4-N-methyl)piperazinosulfonyl]-7-(2-aminoethylamino)-2,1,3-benzoxadiazole
def: "[4-(4-N-methyl)piperazinosulfonyl]-7-(2-aminoethylamino)-2,1,3-benzoxadiazole." [PMID:17590866]
synonym: "MePzBD-Cl" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09262
name: [4-(4-N-methyl)-piperazinosulfonyl]-7-chloro-2,1,3-benzoxadiazole
def: "[4-(4-N-methyl)-piperazinosulfonyl]-7-chloro-2,1,3-benzoxadiazole." [PSI:XL]
synonym: "MePzBD-AE" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09263
name: 4-[[(N-hydrazinoformyl)methyl]-N-methyl]amino-7-[N,N-(dimethylamino)sulfonyl]-2,1,3-benzoxadiazole
def: "4-[[(N-hydrazinoformyl)methyl]-N-methyl]amino-7-[N,N-(dimethylamino)sulfonyl]-2,1,3-benzoxadiazole." [PMID:21639306]
synonym: "DBD-COHZ" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00157 ! benzofurazan

[Term]
id: XLMOD:09264
name: 2,4-Dinitro-6-trifluoromethylphenylhydrazine
def: "2,4-Dinitro-6-trifluoromethylphenylhydrazine." [CAS:119-26-6, PubChem_Compound:3772977, ChemSpiderID:3001507, ChemicalBookNo:CB4852908, PMID:12502079]
synonym: "DNFPH" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00159 ! hydrazine

[Term]
id: XLMOD:09266
name: 2-Amino-N,N,N-trimethylethanaminium chloride
def: "2-Amino-N,N,N-trimethylethanaminium chloride." [ChemSpiderID:2340954]
synonym: "CA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00133 ! amine reactive group

[Term]
id: XLMOD:09267
name: 4-(1'-cyanoisoindolyl)phenylisothiocyanate
def: "4-(1'-cyanoisoindolyl)phenylisothiocyanate." [PMID:12485718]
synonym: "CIPIC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00162 ! isothiocyanate

[Term]
id: XLMOD:09268
name: 2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate
def: "2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate." [CAS:14152-97-7, Beilstein:56699, MDL:MFCD00043085, PubChem_Compound:99462, ChemSpiderID:89858, ChemicalBookNo:CB7320022, PMID:19662356]
synonym: "GITC" EXACT []
synonym: "TAGIT" EXACT []
is_a: XLMOD:06009 ! chiral derivatization reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00162 ! isothiocyanate

[Term]
id: XLMOD:09269
name: 4-Dimethylaminophenyl isothiocyanate
def: "4-Dimethylaminophenyl isothiocyanate." [CAS:2131-64-8, PubChem_Compound:75047, ChemSpiderID:67599, ChemicalBookNo:CB6742874, PMID:23010846]
synonym: "DMAPI" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00162 ! isothiocyanate
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09270
name: dimethylaminoazobenzene isothiocyanate
def: "Dimethylaminoazobenzene isothiocyanate." [CAS:7612-98-8, PubChem_Compound:82084, ChemSpiderID:74082, ChemicalBookNo:74082, PMID:6426344]
synonym: "DABITC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00162 ! isothiocyanate

[Term]
id: XLMOD:09272
name: trimellitic anhydride
def: "Trimellitic anhydride." [CAS:552-30-7, PubChem_Compound:11089, ChemSpiderID:10618, ChemicalBookNo:CB5293056]
synonym: "TMA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00166 ! anhydride

[Term]
id: XLMOD:09274
name: 3-bromoactonyltrimethylammonium bromide
def: "3-bromoactonyltrimethylammonium bromide." [DOI:10.1016/j.trac.2014.03.013]
synonym: "BTA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09275
name: 5,5'-dimethyl-1,3-cyclohexanedione
def: "5,5'-dimethyl-1,3-cyclohexanedione." [CAS:126-81-8, PubChem_Compound:31358, ChemSpiderID:29091, ChemicalBookNo:CB1741746]
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09276
name: 4-(dimethylamino)-benzoic acid
def: "4-(dimethylamino)-benzoic acid." [CAS:619-84-1, PubChem_Compound:12092, ChemSpiderID:11595, ChemicalBookNo:CB4190291]
synonym: "DMBA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09277
name: 1,2-dimethylimidazole-4-sulfonyl chloride
def: "1,2-dimethylimidazole-4-sulfonyl chloride." [CAS:137049-02-6, PubChem_Compound:2736256, ChemSpiderID:2017929, ChemicalBookNo:CB3236772]
synonym: "DMISC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00156 ! sulfonyl chloride

[Term]
id: XLMOD:09278
name: N-(2-ferroceneethyl)maleimide
def: "N-(2-ferroceneethyl)maleimide." [ChemSpiderID:10158611]
synonym: "FEM" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:09279
name: ferrocenecarboxylic acid-(2-maleimidoyl)ethylamide
def: "Ferrocenecarboxylic acid-(2-maleimidoyl)ethylamide." [DOI:10.1016/j.trac.2014.03.013]
synonym: "FMEA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00106 ! maleimide

[Term]
id: XLMOD:09280
name: heptadecafluoroundecylamine
def: "Heptadecafluoroundecylamine." [DOI:10.1016/j.trac.2014.03.013]
synonym: "HFUA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06523 ! sialic acid reactive

[Term]
id: XLMOD:09281
name: 4-hydrazino-N,N,N-trimethyl-4-oxobutanaminium iodide
def: "4-hydrazino-N,N,N-trimethyl-4-oxobutanaminium iodide." [DOI:10.1016/j.trac.2014.03.013]
synonym: "HTMOB" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00031 ! aldehyde reactive
relationship: is_reactive_with XLMOD:06510 ! ketone reactive

[Term]
id: XLMOD:09282
name: 3-aminophenylboronic acid
def: "3-aminophenylboronic acid." [CAS:280563-63-5, PubChem_Compound:92269, ChemSpiderID:83303, ChemicalBookNo:CB3357729]
synonym: "m-APBA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00161 ! boronic acid
relationship: is_reactive_with XLMOD:06512 ! steroid reactive

[Term]
id: XLMOD:09283
name: 1,2-naphthoquinone-4-sulfonate
def: "1,2-naphthoquinone-4-sulfonate." [CAS:2066-93-5, PubChem_Compound:10637, ChemSpiderID:10191, ChemicalBookNo:CB4898119]
synonym: "NQS" EXACT []
synonym: "3,4-dihydro-3,4-dioxonaphthalene-1-sulphonic acid" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00165 ! sulfonate
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09284
name: 2-bromo-4'-chloroacetophenone
def: "2-bromo-4'-chloroacetophenone." [CAS:536-38-9, PubChem_Compound:68303, ChemSpiderID:61599, ChemicalBookNo:CB4198611]
synonym: "p-CPB" EXACT []
synonym: "4-Chloro-2'-bromoacetophenone" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00029 ! sulfhydryl reactive

[Term]
id: XLMOD:09285
name: 1-pyrenemethylamine
def: "1-pyrenemethylamine." [CAS:3786-54-7, PubChem_Compound:2794252, ChemSpiderID:2073158]
synonym: "PMA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09286
name: succinimidylferrocenyl propionate
def: "Succinimidylferrocenyl propionate." [PubChem_Compound:129849850]
synonym: "SFP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09287
name: N-succinimidyl-2(3-pyridyl)acetate
def: "N-succinimidyl-2(3-pyridyl)acetate." [DOI:10.1016/j.trac.2014.03.013]
synonym: "SPA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive

[Term]
id: XLMOD:09288
name: 7-chloro-2,1,3-benzoxadiazole-4-sulfonylaminoethyltrimethylammonium chloride
def: "7-chloro-2,1,3-benzoxadiazole-4-sulfonylaminoethyltrimethylammonium chloride." [DOI:10.1016/j.trac.2014.03.013]
synonym: "TAABD-Cl" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:06513 ! thiol reactive

[Term]
id: XLMOD:09289
name: 1,2-benzo-3,4-dihydrocarbazole-9-p-toluenesulfonate
def: "1,2-benzo-3,4-dihydrocarbazole-9-p-toluenesulfonate." [PMID:17305246]
synonym: "BDETS" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00165 ! sulfonate
relationship: is_reactive_with XLMOD:06524 ! bile acid reactive

[Term]
id: XLMOD:09290
name: tetramethylammonium hydroxide
def: "Tetramethylammonium hydroxide." [CAS:75-59-2, PubChem_Compound:60966, ChemSpiderID:54928, ChemicalBookNo:CB2854236, PMID:19525080]
synonym: "TMAH" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09291
name: trimethylsulfonium hydroxide
def: "Trimethylsulfonium hydroxide." [CAS:17287-03-5, PubChem_Compound:11105313, ChemSpiderID:9280449, ChemicalBookNo:CB1421127, PMID:19525080]
synonym: "TMSH" EXACT []
is_a: XLMOD:06002 ! alkylation reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09292
name: 1-[2-(p-toluenesulfonate)-ethyl]-2-phenylimidazole-[4,5-f-]-9,10-phenantrene
def: "1-[2-(p-toluenesulfonate)-ethyl]-2-phenylimidazole-[4,5-f-]-9,10-phenantrene." [PMID:19525080]
synonym: "TSPP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent

[Term]
id: XLMOD:09293
name: 1-pyrenyldiazomethane
def: "1-pyrenyldiazomethane." [CAS:78377-23-8, PubChem_Compound:2762674, ChemSpiderID:2043377, ChemicalBookNo:CB1374735, DOI:10.1016/j.trac.2011.05.005]
synonym: "PDAM" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent

[Term]
id: XLMOD:09294
name: 4- bromomethyl-6,7-methylenedioxycoumarin
def: "4- bromomethyl-6,7-methylenedioxycoumarin." [CAS:97744-84-8, PubChem_Compound:126818, ChemSpiderID:112631, ChemicalBookNo:CB71326458, PMID:19525080]
synonym: "Br-MDC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09295
name: 9-anthryldiazomethane
def: "9-anthryldiazomethane." [CAS:10401-59-9, PubChem_Compound:3035201, ChemSpiderID:2299498, ChemicalBookNo:CB1185515, PMID:19525080]
synonym: "ADAM" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent

[Term]
id: XLMOD:09296
name: 4-bromomethyl-7,8-benzcoumarin
def: "4-bromomethyl-7,8-benzcoumarin." [PMID:7866666]
synonym: "BrMBC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent

[Term]
id: XLMOD:09297
name: 4-diazomethyl-7-methoxycoumarin
def: "4-diazomethyl-7-methoxycoumarin." [CAS:84471-16-9, PubChem_Compound:54478954, PMID:7866666]
synonym: "DMMC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent

[Term]
id: XLMOD:09298
name: 4-bromomethyl-7-acetoxycoumarin
def: "4-bromomethyl-7-acetoxycoumarin." [CAS:2747-04-8, PubChem_Compound:188296, ChemSpiderID:163663, ChemicalBookNo:CB3141928, PMID:7866666]
synonym: "BrMAC" EXACT []
synonym: "7-Acetoxy-4-bromomethylcoumarin" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent

[Term]
id: XLMOD:09299
name: 4-bromomethyl-6,7-dimethoxycoumarin
def: "4-bromomethyl-6,7-dimethoxycoumarin." [CAS:88404-25-5, PubChem_Compound:128870, ChemSpiderID:114199, ChemicalBookNo:CB8200312, PMID:7866666]
synonym: "BrDMC" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent

[Term]
id: XLMOD:09300
name: N-(1-naphthyl)ethylene diamine dihydrochloride
def: "N-(1-naphthyl)ethylene diamine dihydrochloride." [CAS:1465-25-4, PubChem_Compound:15106, ChemSpiderID:14378, ChemicalBookNo:CB4853112, PMID:19525080]
synonym: "NEDA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00133 ! amine reactive group

[Term]
id: XLMOD:09301
name: 9-aminophenanthrene
def: "9-aminophenanthrene." [CAS:947-73-9, PubChem_Compound:13695, ChemSpiderID:13102, ChemicalBookNo:CB2175009, PMID:6707158]
synonym: "9-AP" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00133 ! amine reactive group

[Term]
id: XLMOD:09302
name: 2-[p-(5,6-Methylenedioxy-2H-benzotriazol-2-yl)]phenethylamine
def: "2-[p-(5,6-Methylenedioxy-2H-benzotriazol-2-yl)]phenethylamine." [PMID:19525080]
synonym: "MBPA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_property XLMOD:00015 ! fluorescent
relationship: has_reactive_group XLMOD:00133 ! amine reactive group

[Term]
id: XLMOD:09303
name: succinimidyloxycarbonylmethyl tris(2,4,6-trimethoxyphenyl)phosphonium bromide
def: "Succinimidyloxycarbonylmethyl tris(2,4,6-trimethoxyphenyl)phosphonium bromide." [ChemSpiderID:24769591, PMID:20533316]
synonym: "TMPP-Ac-OSu" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09304
name: 9-(hydroxymethyl)anthracene
def: "9-(hydroxymethyl)anthracene." [CAS:1468-95-7, PubChem_Compound:73848, ChemSpiderID:66482, ChemicalBookNo:CB1205101, PMID:20533316]
synonym: "HMA" EXACT []
synonym: "9-Anthracenemethanol" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09305
name: 5-dimethylamino-1-naphthalenesulfonyl aminoethanol
def: "5-dimethylamino-1-naphthalenesulfonyl aminoethanol." [PMID:20533316]
synonym: "DNS-AE" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09306
name: 2-(anthracene-2,3-dicarboximdo)ethyl-trifluoromethanesulfonate
def: "2-(anthracene-2,3-dicarboximdo)ethyl-trifluoromethanesulfonate." [PMID:19525080]
synonym: "AE-OTf" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00165 ! sulfonate

[Term]
id: XLMOD:09307
name: 2-(2-naphthoxy)ethyl-2-(piperidino)ethanesulfonate
def: "2-(2-naphthoxy)ethyl-2-(piperidino)ethanesulfonate." [ChemSpiderID:67166452, PMID:19525080]
synonym: "NOEPES" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00165 ! sulfonate

[Term]
id: XLMOD:09308
name: N-(4-Amidobutyl)-N-ethylisoluminol
def: "N-(4-Amidobutyl)-N-ethylisoluminol." [CAS:66612-29-1, PubChem_Compound:196441, ChemSpiderID:170196, ChemicalBookNo:CB8393526, PMID:19525080]
synonym: "ABEI" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09309
name: 6-[N-(4-aminobutyl)methylamino]-2,3-dihydro-1,4-phthalazinedione
def: "6-[N-(4-aminobutyl)methylamino]-2,3-dihydro-1,4-phthalazinedione." [PMID:19525080]
synonym: "ABMI" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09310
name: 6-[N-(3-propionohydrazino)thioureido]benzo[g]-phthalazine-1,4-(2H,3H)-dione
def: "6-[N-(3-propionohydrazino)thioureido]benzo[g]-phthalazine-1,4-(2H,3H)-dione." [PMID:19525080]
synonym: "PRBO" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09311
name: triethylamine
def: "Triethylamine." [CAS:121-44-8, PubChem_Compound:8471, ChemSpiderID:8158, ChemicalBookNo:CB5355941]
synonym: "TEA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09312
name: trifluoroacetic acid
def: "Trifluoroacetic acid." [CAS:76-05-1, PubChem_Compound:6422, ChemSpiderID:10239201, ChemicalBookNo:CB5127175]
synonym: "TFA" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent

[Term]
id: XLMOD:09313
name: p-Bromophenacylate
def: "4-Bromophenacylate." [PSI:XL]
synonym: "Phenacyl-8" EXACT []
is_a: XLMOD:06004 ! acylation reagent
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_fluorophore XLMOD:06111 ! 4-bromophenacyl
relationship: is_reactive_with XLMOD:00030 ! carboxyl reactive

[Term]
id: XLMOD:09314
name: Dabsyl chloride
def: "Dabsyl chloride." [CAS:56512-49-3, PubChem_Compound:91660, Beilstein:3064095, MDL:MFCD00007444, ChemSpiderID:82763, ChemicalBookNo:CB3699737]
synonym: "DAB-Cl" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: has_reactive_group XLMOD:00133 ! amine reactive group

[Term]
id: XLMOD:09315
name: 2,2-dihydroxyindane-1,3-dione
def: "2,2-dihydroxyindane-1,3-dione." [CAS:485-47-2, PubChem_Compound:10236, ChemSpiderID:9819, ChemicalBookNo:CB1337916]
synonym: "Ninhydrin" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive
relationship: is_reactive_with XLMOD:06500 ! secondary amine reactive

[Term]
id: XLMOD:09316
name: 2,4,6-trinitrobenzenesulfonic acid
def: "2,4,6-trinitrobenzenesulfonic acid." [CAS:2508-19-2, PubChem_Compound:11045, ChemSpiderID:10577, ChemicalBookNo:CB3737855]
synonym: "TNBSA" EXACT []
synonym: "Picrylsulfonic acid" EXACT []
is_a: XLMOD:06010 ! LCMS derivatization reagent
relationship: is_reactive_with XLMOD:00028 ! primary amine reactive