format-version: 1.2
ontology: mod
date: 13:06:2021 12:12
saved-by: Joshua Klein
subsetdef: PSI-MOD-slim "subset of protein modifications"
synonymtypedef: DeltaMass-label "Label from MS DeltaMass" EXACT
synonymtypedef: OMSSA-label "Short label from OMSSA" EXACT
synonymtypedef: PSI-MOD-alternate "Alternate name curated by PSI-MOD" EXACT
synonymtypedef: PSI-MOD-label "Short label curated by PSI-MOD" EXACT
synonymtypedef: PSI-MS-label "Agreed label from MS community" RELATED
synonymtypedef: RESID-alternate "Alternate name from RESID" EXACT
synonymtypedef: RESID-misnomer "Misnomer tagged alternate name from RESID" RELATED
synonymtypedef: RESID-name "Name from RESID" EXACT
synonymtypedef: RESID-systematic "Systematic name from RESID" EXACT
synonymtypedef: Unimod-alternate "Alternate name from Unimod" RELATED
synonymtypedef: Unimod-description "Description (full_name) from Unimod" RELATED
synonymtypedef: Unimod-interim "Interim label from Unimod" RELATED
synonymtypedef: UniProt-feature "Protein feature description from UniProtKB" EXACT
default-namespace: PSI-MOD
data-version: 1.031.6
remark: PSI-MOD version: 1.031.6
remark: RESID release: 75.00
remark: ISO-8601 date: 2022-06-13 12:12Z
remark: Annotation note 01 - "[PSI-MOD:ref]" has been replaced by PubMed:18688235.
remark: Annotation note 02 - When an entry in the RESID Database is annotated with different sources because the same modification can arise from different encoded amino acids, then the PSI-MOD definition for each different source instance carries the RESID cross-reference followed by a hash symbol "#" and a 3 or 4 character label. When an entry in the RESID Database is annotated as a general modification with the same enzymatic activity producing different chemical structures depending on natural variation in the nonproteinaceous substrate, on secondary modifications that do not change the nature of the primary modification, or on a combination of a primary and one or more secondary modifications on the same residue, then the PSI-MOD definition for each different instance carries the RESID cross-reference followed by the special tag "#var".
remark: Annotation note 03 - When an entry in the Unimod database is annotated as a general modification, and one or more instance sites are listed, then the PSI-MOD definition for each different site instance carries the Unimod cross-reference followed by a hash symbol and an amino acid code, "N-term" or "C-term".
remark: Annotation note 04 - The elemental formulas are in strict alphabetical order, not in CAS ("C" and "H" first) order. Isotope numbers are in parentheses before the element symbol, and an element should not occur in a formula both with and without an isotope number. In difference formulas, counts can be zero or negative.
remark: Annotation note 05 - In entries with an isotope indicator in the formula, average masses are meaningless and are assigned the value equal to the monoisotopic mass, but rounded to a lower precision; monoisotopic masses are calculated by using the masses for the indicated isotopes and the most common isotopes for other elements without isotope indicators in the formulas.
remark: Annotation note 06 - For cross-link modifications, the number following "Cross-link" in the comment record indicates the number of amino acid residues that appear in the origin record, used to check the difference formula and masses. This usage differs from RESID, where the cross-link number indicates the maximum number of peptide chains that can be cross-linked.
remark: Annotation note 07 - The synonym cross-reference "MOD:old name" has been replaced by "MOD:alternate name".
remark: Annotation note 08 - The DeltaMass listings for free amino acids have been removed. Most Unimod entries that have not been "approved" have by general agreement not been incorporated unless there has been a request for a specific term by a PRIDE submitter.
remark: Annotation note 09 - The Open Mass Spectrometry Search Algorithm, OMSSA, enumerated list of modifications are being incorporated. The string values are synonyms with the synonymtypedef "OMSSA-label", and their integer values (which are supposed to be stable) are definition cross-references.
remark: Annotation note 10 - GNOme is the Glycan Naming and Subsumption Ontology (https://gnome.glyomics.org/), an ontology for the support of glycomics.  PSI-MOD does not have all possible glycans in its entries, just the ones that are noted to be on proteins and have been requested for addition.  GNOme uses GlyTouCan (http://glytoucan.org/) to provide stable accessions for glycans described at varyious degrees of characterization, including compositions (no linkage) and topologies (no carbon bond positions or anomeric configurations).
idspace: uniprot.ptm https://bioregistry.io/uniprot.ptm: "UniProt Post-Translational Modification"

[Term]
id: MOD:00000
name: protein modification
def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModRes" EXACT PSI-MOD-label []

[Term]
id: MOD:00001
name: alkylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an alkyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "AlkylRes" EXACT PSI-MOD-label []
xref: Source: "none"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00002
name: O-glycosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O3-glycosylserine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OGlycoSer" EXACT PSI-MOD-label []
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00396 ! O-glycosylated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00003
name: Unimod
def: "Entry from Unimod." [PubMed:18688235]
comment: This term is for organizational use only and should not be assigned. [JSG]
xref: Source: "none"
is_a: MOD:00032 ! uncategorized protein modification

[Term]
id: MOD:00004
name: artifact
def: "Artifact entry from Unimod - OBSOLETE because organizational use is no longer required." [PubMed:18688235]
is_obsolete: true

[Term]
id: MOD:00005
name: O-glycosyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OGlycoThr" EXACT PSI-MOD-label []
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00396 ! O-glycosylated residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:00006
name: N-glycosylated residue
def: "A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "NGlycoRes" EXACT PSI-MOD-label []
xref: Source: "none"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00007
name: selenium substitution for sulfur
def: "A protein modification that effectively substitutes a selenium atom for a sulfur atom." [PubMed:12148805, Unimod:162]
synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label []
synonym: "Se(S)Res" EXACT PSI-MOD-label []
synonym: "Selenium replaces sulphur" RELATED Unimod-description []
xref: DiffAvg: "46.91"
xref: DiffFormula: "C 0 H 0 N 0 O 0 S -1 Se 1"
xref: DiffMono: "47.944450"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:162"
is_a: MOD:00745 ! selenium containing residue

[Term]
id: MOD:00008
name: common
def: "Entry from Unimod representing one or more entries in RESID. OBSOLETE because organizational use is no longer required." [PubMed:18688235]
is_obsolete: true

[Term]
id: MOD:00009
name: natural residue
def: "A protein modification that removes a residue, or inserts or replaces a residue with a natural, standard or nonstandard, encoded residue." [PubMed:6692818, RESID:AA0000]
subset: PSI-MOD-slim
synonym: "alpha-amino acid" EXACT RESID-name []
synonym: "Res" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "natural"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00010
name: L-alanine residue
def: "A protein modification that effectively converts a source amino acid residue to an L-alanine." [ChEBI:29948, DeltaMass:0, PubMed:6692818, RESID:AA0001]
subset: PSI-MOD-slim
synonym: "(2S)-2-aminopropanoic acid" EXACT RESID-systematic []
synonym: "2-aminopropionic acid" EXACT RESID-alternate []
synonym: "2-azanylpropanoic acid" EXACT RESID-alternate []
synonym: "Ala" EXACT PSI-MOD-label []
synonym: "alpha-alanine" EXACT RESID-alternate []
synonym: "alpha-aminopropionic acid" EXACT RESID-alternate []
synonym: "L-alanine" EXACT RESID-name []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 3 H 5 N 1 O 1"
xref: MassAvg: "71.08"
xref: MassMono: "71.037114"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00570 ! residues isobaric at 71.037114 Da
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00011
name: L-arginine residue
def: "A protein modification that effectively converts a source amino acid residue to an L-arginine." [ChEBI:29952, DeltaMass:0, PubMed:518876, PubMed:6692818, RESID:AA0002]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid" EXACT RESID-systematic []
synonym: "2-amino-5-(carbamimidamido)pentanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "2-amino-5-[(aminoiminomethyl)amino]pentanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "2-amino-5-guanidinopentanoic acid" EXACT RESID-alternate []
synonym: "2-amino-5-guanidinovaleric acid" EXACT RESID-alternate []
synonym: "2-azanyl-5-[bis(azanyl)methylideneazanyl]pentanoic acid" EXACT RESID-alternate []
synonym: "alpha-amino-delta-guanidinovaleric acid" EXACT RESID-alternate []
synonym: "Arg" EXACT PSI-MOD-label []
synonym: "L-arginine" EXACT RESID-name []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 6 H 12 N 4 O 1"
xref: MassAvg: "156.19"
xref: MassMono: "156.101111"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00012
name: L-asparagine residue
def: "A protein modification that effectively converts a source amino acid residue to an L-asparagine." [ChEBI:29956, DeltaMass:0, PubMed:15736973, PubMed:5681232, PubMed:6692818, PubMed:9789001, RESID:AA0003]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-4-butanediamic acid" EXACT RESID-systematic []
synonym: "2,4-bis(azanyl)-4-oxobutanoic acid" EXACT RESID-alternate []
synonym: "2,4-diamino-4-oxobutanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-carbamoylpropanoic acid" EXACT RESID-alternate []
synonym: "2-amino-4-butanediamic acid" EXACT RESID-alternate []
synonym: "2-aminosuccinamic acid" EXACT RESID-alternate []
synonym: "2-aminosuccinic acid 4-amide" EXACT RESID-alternate []
synonym: "alpha-amino-beta-carbamylpropionic acid" EXACT RESID-alternate []
synonym: "alpha-aminosuccinamic acid" EXACT RESID-alternate []
synonym: "Asn" EXACT PSI-MOD-label []
synonym: "aspartic acid 4-amide" EXACT RESID-alternate []
synonym: "aspartic acid beta-amide" EXACT RESID-alternate []
synonym: "beta-asparagine" EXACT RESID-alternate []
synonym: "L-asparagine" EXACT RESID-name []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 4 H 6 N 2 O 2"
xref: MassAvg: "114.10"
xref: MassMono: "114.042927"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00013
name: L-aspartic acid residue
def: "A protein modification that effectively converts a source amino acid residue to an L-aspartic acid." [ChEBI:29958, DeltaMass:0, PubMed:1097438, PubMed:339692, PubMed:4399050, PubMed:5764436, PubMed:6692818, PubMed:8089117, PubMed:9521123, PubMed:9582379, RESID:AA0004]
subset: PSI-MOD-slim
synonym: "(2S)-2-aminobutanedioic acid" EXACT RESID-systematic []
synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate []
synonym: "aminosuccinic acid" EXACT RESID-alternate []
synonym: "Asp" EXACT PSI-MOD-label []
synonym: "L-aspartic acid" EXACT RESID-name []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 4 H 5 N 1 O 3"
xref: MassAvg: "115.09"
xref: MassMono: "115.026943"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00014
name: L-cysteine residue
def: "A protein modification that effectively converts a source amino acid residue to an L-cysteine." [ChEBI:29950, DeltaMass:0, PubMed:1310545, PubMed:15790858, PubMed:3447159, PubMed:6692818, PubMed:7338899, RESID:AA0005]
comment: From DeltaMass: Average Mass: 121.
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "(R)-cysteine" EXACT RESID-alternate []
synonym: "2-amino-3-mercaptopropanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-mercaptopropionic acid" EXACT RESID-alternate []
synonym: "2-azanyl-3-sulfanylpropanoic acid" EXACT RESID-alternate []
synonym: "3-mercapto-L-alanine" EXACT RESID-alternate []
synonym: "alpha-amino-beta-mercaptopropanoic acid" EXACT RESID-alternate []
synonym: "alpha-amino-beta-mercaptopropionic acid" EXACT RESID-alternate []
synonym: "alpha-amino-beta-thiolpropionic acid" EXACT RESID-alternate []
synonym: "beta-mercaptoalanine" EXACT RESID-alternate []
synonym: "Cys" EXACT PSI-MOD-label []
synonym: "Cysteine (C, Cys)" EXACT DeltaMass-label []
synonym: "half-cystine" EXACT RESID-alternate []
synonym: "L-(+)-cysteine" EXACT RESID-alternate []
synonym: "L-cysteine" EXACT RESID-name []
synonym: "thioserine" EXACT RESID-alternate []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 3 H 5 N 1 O 1 S 1"
xref: MassAvg: "103.14"
xref: MassMono: "103.009185"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00015
name: L-glutamic acid residue
def: "A protein modification that effectively converts a source amino acid residue to an L-glutamic acid." [ChEBI:29972, DeltaMass:0, PubMed:1881881, PubMed:4565668, PubMed:4922541, PubMed:6692818, PubMed:9326660, PubMed:957425, RESID:AA0006]
subset: PSI-MOD-slim
synonym: "(2S)-2-aminopentanedioic acid" EXACT RESID-systematic []
synonym: "1-aminopropane-1,3-dicarboxylic acid" EXACT RESID-alternate []
synonym: "2-aminoglutaric acid" EXACT RESID-alternate []
synonym: "2-azanylpentanedioic acid" EXACT RESID-alternate []
synonym: "alpha-aminoglutaric acid" EXACT RESID-alternate []
synonym: "Glu" EXACT PSI-MOD-label []
synonym: "glutaminic acid" EXACT RESID-alternate []
synonym: "L-glutamic acid" EXACT RESID-name []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00016
name: L-glutamine residue
def: "A protein modification that effectively converts a source amino acid residue to an L-glutamine." [ChEBI:30011, DeltaMass:0, PubMed:3340166, PubMed:6692818, PubMed:9342308, RESID:AA0007]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-pentanediamic acid" EXACT RESID-systematic []
synonym: "2,5-bis(azanyl)-5-oxopentanoic acid" EXACT RESID-alternate []
synonym: "2,5-diamino-5-oxopentanoic acid" EXACT RESID-alternate []
synonym: "2-amino-4-carbamoylbutanoic acid" EXACT RESID-alternate []
synonym: "2-aminoglutaramic acid" EXACT RESID-alternate []
synonym: "alpha-amino-gamma-carbamylbutyric acid" EXACT RESID-alternate []
synonym: "Gln" EXACT PSI-MOD-label []
synonym: "glutamic acid 5-amide" EXACT RESID-alternate []
synonym: "glutamic acid gamma-amide" EXACT RESID-alternate []
synonym: "glutamide" EXACT RESID-alternate []
synonym: "L-glutamine" EXACT RESID-name []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 5 H 8 N 2 O 2"
xref: MassAvg: "128.13"
xref: MassMono: "128.058578"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00894 ! residues isobaric at 128.058578 Da
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00017
name: glycine residue
def: "A protein modification that effectively converts a source amino acid residue to a glycine." [ChEBI:29947, DeltaMass:0, PubMed:1310545, PubMed:6692818, RESID:AA0008]
subset: PSI-MOD-slim
synonym: "aminoacetic acid" EXACT RESID-alternate []
synonym: "aminoethanoic acid" EXACT RESID-systematic []
synonym: "azanylethanoic acid" EXACT RESID-alternate []
synonym: "Gly" EXACT PSI-MOD-label []
synonym: "glycine" EXACT RESID-name []
synonym: "glycocoll" EXACT RESID-alternate []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 2 H 3 N 1 O 1"
xref: MassAvg: "57.05"
xref: MassMono: "57.021464"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00018
name: L-histidine residue
def: "A protein modification that effectively converts a source amino acid residue to an L-histidine." [ChEBI:29979, DeltaMass:0, PubMed:14342316, PubMed:2722967, PubMed:512, PubMed:5460889, PubMed:6129252, PubMed:6692818, PubMed:6876174, RESID:AA0009]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic []
synonym: "(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "2-azanyl-3-(1H-imidazol-4-yl)propanoic acid" EXACT RESID-alternate []
synonym: "2-azanyl-3-(1H-imidazol-5-yl)propanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "4-(2-amino-2-carboxyethyl)imidazole" EXACT RESID-alternate []
synonym: "alpha-amino-beta-(4-imidazole)propionic acid" EXACT RESID-alternate []
synonym: "glyoxaline-5-alanine" EXACT RESID-alternate []
synonym: "His" EXACT PSI-MOD-label []
synonym: "L-histidine" EXACT RESID-name []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 6 H 7 N 3 O 1"
xref: MassAvg: "137.14"
xref: MassMono: "137.058912"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00019
name: L-isoleucine residue
def: "A protein modification that effectively converts a source amino acid residue to an L-isoleucine." [ChEBI:30009, DeltaMass:0, PubMed:6692818, RESID:AA0010]
subset: PSI-MOD-slim
synonym: "(2S,3S)-2-amino-3-methylpentanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-methylpentanoic acid" EXACT RESID-alternate []
synonym: "3-methyl-norvaline" EXACT RESID-alternate []
synonym: "alpha-amino-beta-methylvaleric acid" EXACT RESID-alternate []
synonym: "Ile" EXACT PSI-MOD-label []
synonym: "Isoleucyl" EXACT DeltaMass-label []
synonym: "L-erythro-isoleucine" EXACT RESID-alternate []
synonym: "L-isoleucine" EXACT RESID-name []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 6 H 11 N 1 O 1"
xref: MassAvg: "113.16"
xref: MassMono: "113.084064"
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00306 ! residues isobaric at 113.084064 Da
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00020
name: L-leucine residue
def: "A protein modification that effectively converts a source amino acid residue to an L-leucine." [ChEBI:30006, DeltaMass:0, PubMed:11478885, PubMed:6692818, RESID:AA0011]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-4-methylpentanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-4-methylpentanoic acid" EXACT RESID-alternate []
synonym: "4-methyl-norvaline" EXACT RESID-alternate []
synonym: "alpha-amino-gamma-methylvaleric acid" EXACT RESID-alternate []
synonym: "alpha-aminoisocaproic acid" EXACT RESID-alternate []
synonym: "L-leucine" EXACT RESID-name []
synonym: "Leu" EXACT PSI-MOD-label []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 6 H 11 N 1 O 1"
xref: MassAvg: "113.16"
xref: MassMono: "113.084064"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00306 ! residues isobaric at 113.084064 Da
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00021
name: L-lysine residue
def: "A protein modification that effectively converts a source amino acid residue to L-lysine." [ChEBI:29967, DeltaMass:0, PubMed:3106962, PubMed:6120171, PubMed:6692818, RESID:AA0012]
subset: PSI-MOD-slim
synonym: "(2S)-2,6-diaminohexanoic acid" EXACT RESID-systematic []
synonym: "2,6-bis(azanyl)hexanoic acid" EXACT RESID-alternate []
synonym: "6-amino-L-norleucine" EXACT RESID-alternate []
synonym: "ACT_SITE Schiff-base intermediate with substrate" EXACT UniProt-feature []
synonym: "alpha,epsilon-diaminocaproic acid" EXACT RESID-alternate []
synonym: "L-lysine" EXACT RESID-name []
synonym: "Lys" EXACT PSI-MOD-label []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 6 H 12 N 2 O 1"
xref: MassAvg: "128.18"
xref: MassMono: "128.094963"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00893 ! residues isobaric at 128.0-128.1
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00022
name: L-methionine residue
def: "A protein modification that effectively converts a source amino acid residue to L-methionine." [ChEBI:29983, DeltaMass:0, PubMed:6411710, PubMed:6692818, RESID:AA0013]
comment: From DeltaMass: Average Mass: 149
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "2-amino-4-(methylthio)butanoic acid" EXACT RESID-alternate []
synonym: "2-amino-4-(methylthio)butyric acid" EXACT RESID-alternate []
synonym: "2-azanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate []
synonym: "alpha-amino-gamma-methylmercaptobutyric acid" EXACT RESID-alternate []
synonym: "alpha-amino-gamma-methylthiobutyric acid" EXACT RESID-alternate []
synonym: "gamma-methylthio-alpha-aminobutyric acid" EXACT RESID-alternate []
synonym: "L-(-)-methionine" EXACT RESID-alternate []
synonym: "L-methionine" EXACT RESID-name []
synonym: "Met" EXACT PSI-MOD-label []
synonym: "S-methyl-L-homocysteine" EXACT RESID-alternate []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 5 H 9 N 1 O 1 S 1"
xref: MassAvg: "131.19"
xref: MassMono: "131.040485"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00023
name: L-phenylalanine residue
def: "A protein modification that effectively converts a source amino acid residue to L-phenylalanine." [ChEBI:29997, DeltaMass:0, PubMed:6692818, RESID:AA0014]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-phenylpropanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-phenylpropanoic acid" EXACT RESID-alternate []
synonym: "alpha-amino-beta-phenylpropionic acid" EXACT RESID-alternate []
synonym: "L-phenylalanine" EXACT RESID-name []
synonym: "Phe" EXACT PSI-MOD-label []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 9 H 9 N 1 O 1"
xref: MassAvg: "147.18"
xref: MassMono: "147.068414"
xref: Origin: "F"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00024
name: L-proline residue
def: "A protein modification that effectively converts a source amino acid residue to L-proline." [ChEBI:30017, DeltaMass:0, PubMed:6692818, PubMed:8547259, RESID:AA0015]
subset: PSI-MOD-slim
synonym: "(2S)-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic []
synonym: "L-proline" EXACT RESID-name []
synonym: "Pro" EXACT PSI-MOD-label []
synonym: "pyrrolidine-2-carboxylic acid" EXACT RESID-alternate []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 5 H 7 N 1 O 1"
xref: MassAvg: "97.12"
xref: MassMono: "97.052764"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00025
name: L-serine residue
def: "A protein modification that effectively converts a source amino acid residue to L-serine." [ChEBI:29999, DeltaMass:0, PubMed:4399050, PubMed:6692818, RESID:AA0016]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-hydroxypropanoic acid" EXACT RESID-alternate []
synonym: "3-hydroxy-L-alanine" EXACT RESID-alternate []
synonym: "alpha-amino-beta-hydroxypropionic acid" EXACT RESID-alternate []
synonym: "beta-hydroxyalanine" EXACT RESID-alternate []
synonym: "L-serine" EXACT RESID-name []
synonym: "Ser" EXACT PSI-MOD-label []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 3 H 5 N 1 O 2"
xref: MassAvg: "87.08"
xref: MassMono: "87.032028"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00026
name: L-threonine residue
def: "A protein modification that effectively converts a source amino acid residue to L-threonine." [ChEBI:30013, DeltaMass:0, PubMed:2989287, PubMed:6692818, RESID:AA0017]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-hydroxybutanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-hydroxybutanoic acid" EXACT RESID-alternate []
synonym: "alpha-amino-beta-hydroxybutyric acid" EXACT RESID-alternate []
synonym: "beta-methylserine" EXACT RESID-alternate []
synonym: "L-threo-threonine" EXACT RESID-alternate []
synonym: "L-threonine" EXACT RESID-name []
synonym: "Thr" EXACT PSI-MOD-label []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 4 H 7 N 1 O 2"
xref: MassAvg: "101.10"
xref: MassMono: "101.047678"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00027
name: L-tryptophan residue
def: "A protein modification that effectively converts a source amino acid residue to L-tryptophan." [ChEBI:29954, DeltaMass:0, PubMed:2059637, PubMed:6692818, PubMed:9324768, RESID:AA0018]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-alternate []
synonym: "alpha-amino-beta-(3-indolyl)propionoic acid" EXACT RESID-alternate []
synonym: "beta(3-indolyl)alanine" EXACT RESID-alternate []
synonym: "L-tryptophan" EXACT RESID-name []
synonym: "Trp" EXACT PSI-MOD-label []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 11 H 10 N 2 O 1"
xref: MassAvg: "186.21"
xref: MassMono: "186.079313"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00028
name: L-tyrosine residue
def: "A protein modification that effectively converts a source amino acid residue to L-tyrosine." [ChEBI:29975, DeltaMass:0, PubMed:2190093, PubMed:2542938, PubMed:5550972, PubMed:6061414, PubMed:6120171, PubMed:6692818, RESID:AA0019]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-alternate []
synonym: "alpha-amino-beta-(para-hydroxyphenyl)propionic acid" EXACT RESID-alternate []
synonym: "L-tyrosine" EXACT RESID-name []
synonym: "p-tyrosine" EXACT RESID-alternate []
synonym: "para-hydroxyphenylalanine" EXACT RESID-alternate []
synonym: "Tyr" EXACT PSI-MOD-label []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 9 H 9 N 1 O 2"
xref: MassAvg: "163.18"
xref: MassMono: "163.063329"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00029
name: L-valine residue
def: "A protein modification that effectively converts a source amino acid residue to an L-valine." [ChEBI:30015, DeltaMass:0, PubMed:6692818, RESID:AA0020]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-methylbutanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-methylbutanoic acid" EXACT RESID-alternate []
synonym: "alpha-amino-beta-methylbutyric acid" EXACT RESID-alternate []
synonym: "alpha-aminoisovaleric acid" EXACT RESID-alternate []
synonym: "L-valine" EXACT RESID-name []
synonym: "Val" EXACT PSI-MOD-label []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 5 H 9 N 1 O 1"
xref: MassAvg: "99.13"
xref: MassMono: "99.068414"
xref: Origin: "V"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01441 ! natural, standard, encoded residue

[Term]
id: MOD:00030
name: N-formyl-L-methionine residue
def: "A protein modification that effectively converts a source amino acid residue to an N-formyl-L-methionine, a natural pretranslational modification." [ChEBI:33718, OMSSA:22, PubMed:10825024, PubMed:11152118, PubMed:2165784, PubMed:3042771, PubMed:8758896, RESID:AA0021#FMET]
subset: PSI-MOD-slim
synonym: "(2S)-2-formylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "2-formamido-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate []
synonym: "2-formylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate []
synonym: "2-formylazanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate []
synonym: "fMet" EXACT PSI-MOD-label []
synonym: "FormylMet" RELATED PSI-MS-label []
synonym: "MOD_RES N-formylmethionine" EXACT UniProt-feature []
synonym: "N-formyl-L-methionine" EXACT RESID-name []
synonym: "N-formylated L-methionine" EXACT PSI-MOD-alternate []
synonym: "nformylmet" EXACT OMSSA-label []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 6 H 10 N 1 O 2 S 1"
xref: MassAvg: "160.21"
xref: MassMono: "160.043225"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00868 ! natural, non-standard encoded residue

[Term]
id: MOD:00031
name: L-selenocysteine residue
def: "A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification." [ChEBI:30000, PubMed:10523135, PubMed:1066676, PubMed:2037562, PubMed:2963330, PubMed:4734725, PubMed:6076213, PubMed:6217842, PubMed:6714945, RESID:AA0022]
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-selanylpropanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-selanylpropanoic acid" EXACT RESID-alternate []
synonym: "3-selenylalanine" EXACT RESID-alternate []
synonym: "L-selenocysteine" EXACT RESID-name []
synonym: "NON_STD Selenocysteine" EXACT UniProt-feature []
synonym: "Sec" EXACT PSI-MOD-label []
synonym: "SeCys" EXACT RESID-alternate []
synonym: "selenium cysteine" EXACT RESID-alternate []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0 Se 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 3 H 5 N 1 O 1 Se 1"
xref: MassAvg: "150.05"
xref: MassMono: "150.953635"
xref: Origin: "U"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00745 ! selenium containing residue
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:00868 ! natural, non-standard encoded residue

[Term]
id: MOD:00032
name: uncategorized protein modification
def: "A protein modification that is not chemically categorized." [PubMed:18688235]
comment: This term is for organizational use only and should not be assigned. [JSG]
xref: Source: "none"
is_a: MOD:00000 ! protein modification

[Term]
id: MOD:00033
name: crosslinked residues
def: "A protein modification that crosslinks two or more amino acid residues with covalent bonds." [PubMed:18688235]
comment: The covalent bond is formed directly between sidechain atoms. If non-aminoacid atoms are involved in connecting two or more peptide chain residues peptide chain, the connection is classified as a multivalent binding site.
subset: PSI-MOD-slim
synonym: "XLNK-Res-Res" EXACT PSI-MOD-label []
xref: Source: "none"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00034
name: L-cystine (cross-link)
def: "A protein modification that effectively cross-links two L-cysteine residues to form L-cystine." [ChEBI:16283, DeltaMass:0, PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, RESID:AA0025#CYS2]
comment: Cross-link 2; for formation of a disulfide bond between a peptide cysteine and a free cysteine, see MOD:00765.
subset: PSI-MOD-slim
synonym: "(2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic []
synonym: "2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid" RELATED RESID-misnomer []
synonym: "3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid)" EXACT RESID-alternate []
synonym: "3,3'-dithiobis(2-aminopropanoic acid)" EXACT RESID-alternate []
synonym: "3,3'-dithiobisalanine" EXACT RESID-alternate []
synonym: "3,3'-dithiodialanine" EXACT RESID-alternate []
synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide" EXACT RESID-alternate []
synonym: "beta,beta'-dithiodialanine" EXACT RESID-alternate []
synonym: "bis(alpha-aminopropionic acid)-beta-disulfide" EXACT RESID-alternate []
synonym: "bis(beta-amino-beta-carboxyethyl)disulfide" EXACT RESID-alternate []
synonym: "Cys2" EXACT PSI-MOD-label []
synonym: "Cystine ((Cys)2)" EXACT DeltaMass-label []
synonym: "dicysteine" EXACT RESID-alternate []
synonym: "DISULFID" EXACT UniProt-feature []
synonym: "DISULFID Interchain" EXACT UniProt-feature []
synonym: "L-cystine" EXACT RESID-name []
synonym: "XLNK-SCys-SCys" EXACT PSI-MOD-label []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 6 H 8 N 2 O 2 S 2"
xref: MassAvg: "204.26"
xref: MassMono: "204.002720"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00689 ! disulfide crosslinked residues

[Term]
id: MOD:00035
name: (2S,3R)-3-hydroxyasparagine
def: "A protein modification that effectively converts an L-asparagine residue to (2S,3R)-3-hydroxyasparagine." [PubMed:11823643, PubMed:2820791, RESID:AA0026, ChEBI:141853]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2,4-diamino-3-hydroxy-4-oxobutanoic acid" EXACT RESID-alternate []
synonym: "(2S,3R)-2-amino-3-hydroxy-4-butanediamic acid" EXACT RESID-systematic []
synonym: "(2S,3R)-3-hydroxyasparagine" EXACT RESID-name []
synonym: "(3R)3HyAsn" EXACT PSI-MOD-label []
synonym: "2-azanyl-3-hydroxy-4-butanediamic acid" EXACT RESID-alternate []
synonym: "erythro-beta-hydroxylated L-asparagine" EXACT PSI-MOD-alternate []
synonym: "L-erythro-beta-hydroxyasparagine" EXACT RESID-alternate []
synonym: "MOD_RES (3R)-3-hydroxyasparagine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 4 H 6 N 2 O 3"
xref: MassAvg: "130.10"
xref: MassMono: "130.037842"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0369
is_a: MOD:01688 ! 3-hydroxy-L-asparagine

[Term]
id: MOD:00036
name: (2S,3R)-3-hydroxyaspartic acid
def: "A protein modification that effectively converts an L-aspartic acid residue to (2S,3R)-3-hydroxyaspartic acid." [OMSSA:59, PubMed:6572939, PubMed:6871167, PubMed:8355279, RESID:AA0027, Unimod:35#D, ChEBI:141848]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-hydroxybutanedioic acid" EXACT RESID-systematic []
synonym: "(2S,3R)-3-hydroxyaspartic acid" EXACT RESID-name []
synonym: "(3R)3HyAsp" EXACT PSI-MOD-label []
synonym: "2-amino-3-hydroxysuccinic acid" EXACT RESID-alternate []
synonym: "2-azanyl-3-hydroxybutanedioic acid" EXACT RESID-alternate []
synonym: "3-hydroxyaspartic acid" EXACT RESID-alternate []
synonym: "erythro-beta-hydroxylated L-aspartic acid" EXACT PSI-MOD-alternate []
synonym: "hydroxylationd" EXACT OMSSA-label []
synonym: "L-erythro-beta-hydroxyaspartic acid" EXACT RESID-alternate []
synonym: "MOD_RES (3R)-3-hydroxyaspartate" EXACT UniProt-feature []
synonym: "Oxidation" RELATED PSI-MS-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 4 H 5 N 1 O 4"
xref: MassAvg: "131.09"
xref: MassMono: "131.021858"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:35"
xref: uniprot.ptm:PTM-0371
is_a: MOD:01926 ! 3-hydroxy-L-aspartic acid

[Term]
id: MOD:00037
name: 5-hydroxy-L-lysine
def: "A protein modification that effectively converts an L-lysine  residue to one of the diastereomeric 5-hydroxy-L-lysine  residues." [ChEBI:60175, PubMed:18688235]
subset: PSI-MOD-slim
synonym: "5-hydroxylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "5HyLys" EXACT PSI-MOD-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 12 N 2 O 2"
xref: MassAvg: "144.17"
xref: MassMono: "144.089878"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0044
is_a: MOD:01047 ! monohydroxylated lysine

[Term]
id: MOD:00038
name: 3-hydroxy-L-proline
def: "A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline." [ChEBI:16889, PubMed:2400108, PubMed:3734192, PubMed:4343807, RESID:AA0029]
subset: PSI-MOD-slim
synonym: "(2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "3-hydroxy-L-proline" EXACT RESID-name []
synonym: "3-hydroxylated L-proline" EXACT PSI-MOD-alternate []
synonym: "3-trans-hydroxy-L-proline" EXACT RESID-alternate []
synonym: "3HyPro" EXACT PSI-MOD-label []
synonym: "beta-hydroxypyrrolidine-alpha-carboxylic acid" EXACT RESID-alternate []
synonym: "L-threo-3-hydroxyproline" EXACT RESID-alternate []
synonym: "MOD_RES 3-hydroxyproline" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 7 N 1 O 2"
xref: MassAvg: "113.12"
xref: MassMono: "113.047678"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0030
is_a: MOD:01024 ! monohydroxylated proline

[Term]
id: MOD:00039
name: 4-hydroxy-L-proline
def: "A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline" [ChEBI:18095, PubMed:11292863, PubMed:2400108, PubMed:3734192, RESID:AA0030]
subset: PSI-MOD-slim
synonym: "(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "4-hydroxy-L-proline" EXACT RESID-name []
synonym: "4-hydroxylated L-proline" EXACT PSI-MOD-alternate []
synonym: "4-hydroxyproline" EXACT RESID-alternate []
synonym: "4-trans-hydroxy-L-proline" EXACT RESID-alternate []
synonym: "4HyPro" EXACT PSI-MOD-label []
synonym: "gamma-hydroxypyrrolidine-alpha-carboxylic acid" EXACT RESID-alternate []
synonym: "L-threo-4-hydroxyproline" EXACT RESID-alternate []
synonym: "MOD_RES 4-hydroxyproline" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 7 N 1 O 2"
xref: MassAvg: "113.12"
xref: MassMono: "113.047678"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0043
is_a: MOD:01024 ! monohydroxylated proline

[Term]
id: MOD:00040
name: 2-pyrrolidone-5-carboxylic acid (Gln)
def: "A protein modification that effectively converts an L-glutamine residue to 2-pyrrolidone-5-carboxylic acid." [ChEBI:30652, DeltaMass:123, OMSSA:110, PubMed:10214721, PubMed:1836357, PubMed:26343, PubMed:3473473, RESID:AA0031#GLN, Unimod:28#Q]
comment: DeltaMass gives a formula C 5 H 5 N 1 O 2 with mass 111.1
subset: PSI-MOD-slim
synonym: "(2S)-5-oxo-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic []
synonym: "2-oxopyrrolidine-5-carboxylic acid" EXACT RESID-alternate []
synonym: "2-pyrrolidone-5-carboxylic acid" EXACT RESID-name []
synonym: "5-oxoproline" EXACT RESID-alternate []
synonym: "5-oxopyrrolidine-2-carboxylic acid" EXACT RESID-alternate []
synonym: "5-pyrrolidone-2-carboxylic acid" EXACT RESID-alternate []
synonym: "Gln->pyro-Glu" RELATED PSI-MS-label []
synonym: "MOD_RES Pyrrolidone carboxylic acid" EXACT UniProt-feature []
synonym: "N-pyrrolidone carboxyl (N terminus)" EXACT DeltaMass-label []
synonym: "ntermpeppyroq" EXACT OMSSA-label []
synonym: "PCA" EXACT RESID-alternate []
synonym: "PyrGlu(Gln)" EXACT PSI-MOD-label []
synonym: "Pyro-glu from Q" RELATED Unimod-description []
synonym: "pyroglutamic acid" EXACT RESID-alternate []
synonym: "Pyroglutamic Acid formed from Gln" EXACT DeltaMass-label []
synonym: "Pyroglutamyl" EXACT DeltaMass-label []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 5 H 6 N 1 O 2"
xref: MassAvg: "112.11"
xref: MassMono: "112.039853"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:28"
xref: uniprot.ptm:PTM-0261
is_a: MOD:00907 ! modified L-glutamine residue
is_a: MOD:01048 ! 2-pyrrolidone-5-carboxylic acid
is_a: MOD:01160 ! deaminated residue

[Term]
id: MOD:00041
name: L-gamma-carboxyglutamic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid." [DeltaMass:217, OMSSA:48, PubMed:10517147, PubMed:1807167, PubMed:3263814, PubMed:4528109, PubMed:7457858, PubMed:8135347, PubMed:8868490, PubMed:9188685, RESID:AA0032, Unimod:299#E]
comment: DeltaMass has an incorrect formula C 6 H 7 N 5 O 1 (N and O reversed) with mass 173.
subset: PSI-MOD-slim
synonym: "(3S)-3-aminopropane-1,1,3-tricarboxylic acid" EXACT RESID-systematic []
synonym: "(3S)-3-azanylpropane-1,1,3-tricarboxylic acid" EXACT RESID-alternate []
synonym: "1-carboxyglutamic acid" RELATED RESID-misnomer []
synonym: "3-amino-1,1,3-propanetricarboxylic acid" EXACT RESID-alternate []
synonym: "3-azanylpropane-1,1,3-tricarboxylic acid" EXACT RESID-alternate []
synonym: "4-carboxyglutamic acid" EXACT RESID-alternate []
synonym: "4CbxGlu" EXACT PSI-MOD-label []
synonym: "Carboxy" RELATED PSI-MS-label []
synonym: "Carboxy" RELATED Unimod-interim []
synonym: "Carboxy Glutamyl" EXACT DeltaMass-label []
synonym: "Carboxylation" RELATED Unimod-description []
synonym: "gamma-carboxylated L-glutamic acid" EXACT PSI-MOD-alternate []
synonym: "gammacarboxyle" EXACT OMSSA-label []
synonym: "L-gamma-carboxyglutamic acid" EXACT RESID-name []
synonym: "MOD_RES 4-carboxyglutamate" EXACT UniProt-feature []
xref: DiffAvg: "44.01"
xref: DiffFormula: "C 1 H 0 N 0 O 2"
xref: DiffMono: "43.989829"
xref: Formula: "C 6 H 7 N 1 O 5"
xref: MassAvg: "173.12"
xref: MassMono: "173.032422"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:299"
xref: uniprot.ptm:PTM-0039
is_a: MOD:00906 ! modified L-glutamic acid residue
is_a: MOD:01152 ! carboxylated residue

[Term]
id: MOD:00042
name: L-aspartic 4-phosphoric anhydride
def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartic 4-phosphoric anhydride." [ChEBI:15836, PubMed:4357737, RESID:AA0033, Unimod:21#D]
synonym: "(2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acid" EXACT RESID-systematic []
synonym: "2-aminobutanedioic 4-phosphoric anhydride" EXACT RESID-alternate []
synonym: "2-azanyl-4-oxo-4-(phosphonooxy)butanoic acid" EXACT RESID-alternate []
synonym: "4-oxo-O-phosphono-L-homoserine" EXACT RESID-alternate []
synonym: "4-phosphoaspartic acid" EXACT RESID-alternate []
synonym: "4-phosphorylated L-aspartatic acid" EXACT PSI-MOD-alternate []
synonym: "ACT_SITE 4-aspartylphosphate intermediate" EXACT UniProt-feature []
synonym: "beta-aspartyl phosphate" EXACT RESID-alternate []
synonym: "L-aspartic 4-phosphoric anhydride" EXACT RESID-name []
synonym: "MOD_RES 4-aspartylphosphate" EXACT UniProt-feature []
synonym: "PAsp" EXACT PSI-MOD-label []
synonym: "Phospho" RELATED PSI-MS-label []
synonym: "Phosphorylation" RELATED Unimod-description []
xref: DiffAvg: "79.98"
xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "C 4 H 6 N 1 O 6 P 1"
xref: MassAvg: "195.07"
xref: MassMono: "194.993274"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:21"
xref: uniprot.ptm:PTM-0038
is_a: MOD:00904 ! modified L-aspartic acid residue
is_a: MOD:01455 ! O-phosphorylated residue

[Term]
id: MOD:00043
name: S-phospho-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-phospho-L-cysteine." [PubMed:3142516, PubMed:7961745, PubMed:8128219, RESID:AA0034, Unimod:21#C]
synonym: "(2R)-2-amino-3-(phosphonosulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-(phosphonosulfanyl)propanoic acid" EXACT RESID-alternate []
synonym: "ACT_SITE Phosphocysteine intermediate" EXACT UniProt-feature []
synonym: "cysteine phosphate thioester" EXACT RESID-alternate []
synonym: "MOD_RES Phosphocysteine" EXACT UniProt-feature []
synonym: "PCys" EXACT PSI-MOD-label []
synonym: "Phospho" RELATED PSI-MS-label []
synonym: "Phosphorylation" RELATED Unimod-description []
synonym: "S-phospho-L-cysteine" EXACT RESID-name []
synonym: "S-phosphonocysteine" EXACT RESID-alternate []
synonym: "S-phosphorylated L-cysteine" EXACT PSI-MOD-alternate []
synonym: "S3-phosphocysteine" EXACT RESID-alternate []
xref: DiffAvg: "79.98"
xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1 S 0"
xref: DiffMono: "79.966331"
xref: Formula: "C 3 H 6 N 1 O 4 P 1 S 1"
xref: MassAvg: "183.12"
xref: MassMono: "182.975515"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:21"
xref: uniprot.ptm:PTM-0251
is_a: MOD:00696 ! phosphorylated residue
is_a: MOD:00777 ! residues isobaric at 182.96-182.98 Da
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00044
name: 1'-phospho-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to tele-phospho-L-histidine (N-tau-phospho-L-histidine, 1'-phospho-L-histidine)." [PubMed:11038361, PubMed:5642389, PubMed:6692818, RESID:AA0035]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic []
synonym: "1'-phospho-L-histidine" EXACT RESID-name []
synonym: "2-azanyl-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid" EXACT RESID-alternate []
synonym: "ACT_SITE Tele-phosphohistidine intermediate" EXACT UniProt-feature []
synonym: "histidine-3-phosphate" RELATED RESID-misnomer []
synonym: "histidine-N(epsilon)-phosphate" EXACT RESID-alternate []
synonym: "histidine-N1'-phosphate" EXACT RESID-alternate []
synonym: "MOD_RES Tele-phosphohistidine" EXACT UniProt-feature []
synonym: "N(tau)-phosphohistidine" EXACT RESID-alternate []
synonym: "N1-phosphonohistidine" EXACT RESID-alternate []
synonym: "NE2-phosphonohistidine" EXACT RESID-alternate []
synonym: "Ntau-phosphorylated L-histidine" EXACT PSI-MOD-alternate []
synonym: "NtPHis" EXACT PSI-MOD-label []
synonym: "Phospho" RELATED PSI-MS-label []
synonym: "Phosphorylation" RELATED Unimod-description []
synonym: "tele-phosphohistidine" EXACT RESID-alternate []
xref: DiffAvg: "79.98"
xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "C 6 H 8 N 3 O 4 P 1"
xref: MassAvg: "217.12"
xref: MassMono: "217.025242"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0325
is_a: MOD:00890 ! phosphorylated L-histidine

[Term]
id: MOD:00045
name: 3'-phospho-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to pros-phospho-L-histidine (N-pi-phospho-L-histidine, 3'-phospho-L-histidine)." [PubMed:1549615, PubMed:5642389, PubMed:6692818, PubMed:7669763, PubMed:7803390, RESID:AA0036]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid" EXACT RESID-alternate []
synonym: "3'-phospho-L-histidine" EXACT RESID-name []
synonym: "ACT_SITE Pros-phosphohistidine intermediate" EXACT UniProt-feature []
synonym: "histidine-1-phosphate" RELATED RESID-misnomer []
synonym: "histidine-N(delta)-phosphate" EXACT RESID-alternate []
synonym: "histidine-N3'-phosphate" EXACT RESID-alternate []
synonym: "MOD_RES Pros-phosphohistidine" EXACT UniProt-feature []
synonym: "N(pi)-phosphohistidine" EXACT RESID-alternate []
synonym: "N3-phosphonohistidine" EXACT RESID-alternate []
synonym: "ND1-phosphonohistidine" EXACT RESID-alternate []
synonym: "Npi-phosphorylated L-histidine" EXACT PSI-MOD-alternate []
synonym: "NpPHis" EXACT PSI-MOD-label []
synonym: "Phospho" RELATED PSI-MS-label []
synonym: "Phosphorylation" RELATED Unimod-description []
synonym: "pros-phosphohistidine" EXACT RESID-alternate []
xref: DiffAvg: "79.98"
xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "C 6 H 8 N 3 O 4 P 1"
xref: MassAvg: "217.12"
xref: MassMono: "217.025242"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0260
is_a: MOD:00890 ! phosphorylated L-histidine

[Term]
id: MOD:00046
name: O-phospho-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-phospho-L-serine." [ChEBI:15811, DeltaMass:0, OMSSA:6, PubMed:12923550, PubMed:4065410, PubMed:8061611, RESID:AA0037, Unimod:21#S]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(phosphonooxy)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-hydroxypropanoic acid 3-phosphate" EXACT RESID-alternate []
synonym: "2-azanyl-3-(phosphonooxy)propanoic acid" EXACT RESID-alternate []
synonym: "ACT_SITE Phosphoserine intermediate" EXACT UniProt-feature []
synonym: "MOD_RES Phosphoserine" EXACT UniProt-feature []
synonym: "O-phospho-L-serine" EXACT RESID-name []
synonym: "O-phosphonoserine" EXACT RESID-alternate []
synonym: "O-phosphorylated L-serine" EXACT PSI-MOD-alternate []
synonym: "O3-phosphoserine" EXACT RESID-alternate []
synonym: "OPSer" EXACT PSI-MOD-label []
synonym: "Phospho" RELATED PSI-MS-label []
synonym: "Phospho Seryl" EXACT DeltaMass-label []
synonym: "Phosphorylation" RELATED Unimod-description []
synonym: "phosphorylations" EXACT OMSSA-label []
synonym: "serine phosphate ester" EXACT RESID-alternate []
xref: DiffAvg: "79.98"
xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "C 3 H 6 N 1 O 5 P 1"
xref: MassAvg: "167.06"
xref: MassMono: "166.998359"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:21"
xref: uniprot.ptm:PTM-0253
is_a: MOD:00771 ! residues isobaric at 166.98-167.00 Da
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01455 ! O-phosphorylated residue

[Term]
id: MOD:00047
name: O-phospho-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine." [ChEBI:21967, DeltaMass:0, OMSSA:7, PubMed:12923550, PubMed:7678926, RESID:AA0038, Unimod:21#T]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-(phosphonooxy)butanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-hydroxybutanoic acid 3-phosphate" EXACT RESID-alternate []
synonym: "2-azanyl-3-(phosphonooxy)butanoic acid" EXACT RESID-alternate []
synonym: "MOD_RES Phosphothreonine" EXACT UniProt-feature []
synonym: "O-phospho-L-threonine" EXACT RESID-name []
synonym: "O-phosphorylated L-threonine" EXACT PSI-MOD-alternate []
synonym: "O3-phosphothreonine" EXACT RESID-alternate []
synonym: "OPThr" EXACT PSI-MOD-label []
synonym: "Phospho" RELATED PSI-MS-label []
synonym: "Phospho Threonyl" EXACT DeltaMass-label []
synonym: "Phosphorylation" RELATED Unimod-description []
synonym: "phosphorylationt" EXACT OMSSA-label []
synonym: "threonine phosphate ester" EXACT RESID-alternate []
xref: DiffAvg: "79.98"
xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "C 4 H 8 N 1 O 5 P 1"
xref: MassAvg: "181.08"
xref: MassMono: "181.014009"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:21"
xref: uniprot.ptm:PTM-0254
is_a: MOD:00773 ! residues isobaric at 181.00-181.02 Da
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:01455 ! O-phosphorylated residue

[Term]
id: MOD:00048
name: O4'-phospho-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine." [DeltaMass:0, OMSSA:8, PubMed:10226369, PubMed:1725475, RESID:AA0039, Unimod:21#Y]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate" EXACT RESID-alternate []
synonym: "2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid" EXACT RESID-alternate []
synonym: "MOD_RES Phosphotyrosine" EXACT UniProt-feature []
synonym: "O4'-phospho-L-tyrosine" EXACT RESID-name []
synonym: "O4'-phosphorylated L-tyrosine" EXACT PSI-MOD-alternate []
synonym: "O4-phosphotyrosine" EXACT RESID-alternate []
synonym: "OPTyr" EXACT PSI-MOD-label []
synonym: "Phospho" RELATED PSI-MS-label []
synonym: "Phospho Tyrosinyl" EXACT DeltaMass-label []
synonym: "Phosphorylation" RELATED Unimod-description []
synonym: "phosphorylationy" EXACT OMSSA-label []
synonym: "tyrosine phosphate" EXACT RESID-alternate []
xref: DiffAvg: "79.98"
xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "C 9 H 10 N 1 O 5 P 1"
xref: MassAvg: "243.15"
xref: MassMono: "243.029659"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:21"
xref: uniprot.ptm:PTM-0255
is_a: MOD:00774 ! residues isobaric at 243.02-243.03 Da
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01455 ! O-phosphorylated residue

[Term]
id: MOD:00049
name: 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to diphthamide." [ChEBI:16692, DeltaMass:122, PubMed:15316019, PubMed:7430147, RESID:AA0040, Unimod:375#H]
synonym: "(2R)-1-amino-4-(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-aminium" EXACT RESID-systematic []
synonym: "(3-[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]-1-carbamoyl-propyl)-trimethylammonium" EXACT RESID-alternate []
synonym: "1-azanyl-4-(4-[2-azanyl-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-azanium" EXACT RESID-alternate []
synonym: "2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine" EXACT RESID-name []
synonym: "2-[(R)-3-carboxamido-3-(trimethylammonio)propyl]-4-((S)-2-amino-2-carboxyethyl)-1H-imidazole" EXACT RESID-alternate []
synonym: "2-[3-carboxamido-3-(trimethylammonio)propyl]histidine" EXACT RESID-alternate []
synonym: "2-amino-3-[[2-(3-amino-3-carbamoyl-prop-1-enyl)-1,1,3-trimethyl-2,3-dihydroimidazol-5-yl]]propanoic acid" EXACT RESID-alternate []
synonym: "2-amino-4-[[5-(2-amino-2-carboxylato-ethyl)-1,1,3-trimethyl-2,3-dihydroimidazol-2-yl]]but-3-enamide" EXACT RESID-alternate []
synonym: "alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-1H-imidazole-2-propanaminium" EXACT RESID-alternate []
synonym: "Diphth" EXACT PSI-MOD-label []
synonym: "Diphthamide" RELATED PSI-MS-label []
synonym: "Diphthamide" RELATED Unimod-description []
synonym: "diphthamide" EXACT RESID-alternate []
synonym: "diphthamide (from histidine)" EXACT DeltaMass-label []
synonym: "MOD_RES Diphthamide" EXACT UniProt-feature []
xref: DiffAvg: "143.21"
xref: DiffFormula: "C 7 H 15 N 2 O 1"
xref: DiffMono: "143.117890"
xref: FormalCharge: "1+"
xref: Formula: "C 13 H 22 N 5 O 2"
xref: MassAvg: "280.35"
xref: MassMono: "280.176801"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:375"
xref: uniprot.ptm:PTM-0118
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:00050
name: N-acetyl-L-alanine
def: "A protein modification that effectively converts an L-alanine residue to N-acetyl-L-alanine." [PubMed:363452, PubMed:4700463, RESID:AA0041]
subset: PSI-MOD-slim
synonym: "(2S)-2-(acetamido)propanoic acid" EXACT RESID-systematic []
synonym: "2-(acetylamino)propanoic acid" EXACT RESID-alternate []
synonym: "2-(acetylazanyl)propanoic acid" EXACT RESID-alternate []
synonym: "AcAla" EXACT PSI-MOD-label []
synonym: "acetylalanine" EXACT RESID-alternate []
synonym: "MOD_RES N-acetylalanine" EXACT UniProt-feature []
synonym: "N-acetyl-L-alanine" EXACT RESID-name []
synonym: "N-acetylated L-alanine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 5 H 8 N 1 O 2"
xref: MassAvg: "114.12"
xref: MassMono: "114.055504"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0199
is_a: MOD:00901 ! modified L-alanine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00051
name: N-acetyl-L-aspartic acid
def: "A protein modification that effectively converts an L-aspartic acid residue to N-acetyl-L-aspartic acid." [ChEBI:21547, PubMed:1560020, PubMed:2395459, RESID:AA0042]
subset: PSI-MOD-slim
synonym: "(2S)-2-(acetamido)butanedioic acid" EXACT RESID-systematic []
synonym: "2-(acetylamino)butanedioic acid" EXACT RESID-alternate []
synonym: "2-(acetylazanyl)butanedioic acid" EXACT RESID-alternate []
synonym: "AcAsp" EXACT PSI-MOD-label []
synonym: "acetylaspartic acid" EXACT RESID-alternate []
synonym: "MOD_RES N-acetylaspartate" EXACT UniProt-feature []
synonym: "N-acetyl-L-aspartic acid" EXACT RESID-name []
synonym: "N-acetylated L-aspartic acid" EXACT PSI-MOD-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 6 H 8 N 1 O 4"
xref: MassAvg: "158.13"
xref: MassMono: "158.045333"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0200
is_a: MOD:00904 ! modified L-aspartic acid residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00052
name: N-acetyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to N-acetyl-L-cysteine." [ChEBI:28939, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:1500421, PubMed:15350136, PubMed:6725286, RESID:AA0043]
comment: incidental to RESID:AA0223
subset: PSI-MOD-slim
synonym: "(2R)-2-acetamido-3-sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "2-acetylamino-3-mercaptopropanoic acid" EXACT RESID-alternate []
synonym: "2-acetylamino-3-sulfanylpropanoic acid" EXACT RESID-alternate []
synonym: "2-acetylazanyl-3-sulfanylpropanoic acid" EXACT RESID-alternate []
synonym: "Acetyl" RELATED PSI-MS-label []
synonym: "MOD_RES N-acetylcysteine" EXACT UniProt-feature []
synonym: "N-acetyl-L-cysteine" EXACT RESID-name []
synonym: "N-acetylated cysteine" EXACT PSI-MOD-alternate []
synonym: "N-acetylcysteine" EXACT RESID-alternate []
synonym: "NAcCys" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0"
xref: DiffMono: "42.010565"
xref: Formula: "C 5 H 8 N 1 O 2 S 1"
xref: MassAvg: "146.18"
xref: MassMono: "146.027574"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0201
is_a: MOD:00646 ! acetylated L-cysteine
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00053
name: N-acetyl-L-glutamic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to N-acetyl-L-glutamic acid." [ChEBI:17533, PubMed:6725286, RESID:AA0044]
subset: PSI-MOD-slim
synonym: "(2S)-2-(acetamido)pentanedioic acid" EXACT RESID-systematic []
synonym: "2-(acetylamino)pentanedioic acid" EXACT RESID-alternate []
synonym: "2-(acetylazanyl)pentanedioic acid" EXACT RESID-alternate []
synonym: "acetylglutamic acid" EXACT RESID-alternate []
synonym: "AcGlu" EXACT PSI-MOD-label []
synonym: "MOD_RES N-acetylglutamate" EXACT UniProt-feature []
synonym: "N-acetyl-L-glutamic acid" EXACT RESID-name []
synonym: "N-acetylated L-glutamic acid" EXACT PSI-MOD-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 7 H 10 N 1 O 4"
xref: MassAvg: "172.16"
xref: MassMono: "172.060983"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0202
is_a: MOD:00906 ! modified L-glutamic acid residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00054
name: N-acetyl-L-glutamine
def: "A protein modification that effectively converts an L-glutamine residue to N-acetyl-L-glutamine." [RESID:AA0045]
comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "(2S)-2-acetamido-5-pentanediamic acid" EXACT RESID-systematic []
synonym: "2-acetylamino-5-amino-5-oxopentanoic acid" EXACT RESID-alternate []
synonym: "2-acetylamino-5-pentanediamic acid" EXACT RESID-alternate []
synonym: "2-acetylazanyl-5-azanyl-5-oxopentanoic acid" EXACT RESID-alternate []
synonym: "acetylglutamine" EXACT RESID-alternate []
synonym: "AcGln" EXACT PSI-MOD-label []
synonym: "N-acetyl-L-glutamine" EXACT RESID-name []
synonym: "N-acetylated L-glutamine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 7 H 11 N 2 O 3"
xref: MassAvg: "171.18"
xref: MassMono: "171.076967"
xref: Origin: "Q"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00907 ! modified L-glutamine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00055
name: N-acetylglycine
def: "A protein modification that effectively converts a glycine residue to N-acetylglycine." [PubMed:272676, PubMed:5545094, PubMed:6754709, RESID:AA0046]
subset: PSI-MOD-slim
synonym: "(acetylamino)acetic acid" EXACT RESID-alternate []
synonym: "(acetylazanyl)ethanoic acid" EXACT RESID-alternate []
synonym: "2-(acetamido)ethanoic acid" EXACT RESID-systematic []
synonym: "2-(acetylamino)ethanoic acid" EXACT RESID-alternate []
synonym: "aceturic acid" EXACT RESID-alternate []
synonym: "AcGly" EXACT PSI-MOD-label []
synonym: "MOD_RES N-acetylglycine" EXACT UniProt-feature []
synonym: "N-acetylated glycine" EXACT PSI-MOD-alternate []
synonym: "N-acetylglycine" EXACT RESID-name []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 4 H 6 N 1 O 2"
xref: MassAvg: "100.10"
xref: MassMono: "100.039853"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0203
is_a: MOD:00908 ! modified glycine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00056
name: N-acetyl-L-isoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to N-acetyl-L-isoleucine." [PubMed:8034631, RESID:AA0047]
comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "(2S,3S)-2-acetamido-3-methylpentanoic acid" EXACT RESID-systematic []
synonym: "2-acetylamino-3-methylpentanoic acid" EXACT RESID-alternate []
synonym: "2-acetylazanyl-3-methylpentanoic acid" EXACT RESID-alternate []
synonym: "acetylisoleucine" EXACT RESID-alternate []
synonym: "AcIle" EXACT PSI-MOD-label []
synonym: "N-acetyl-L-isoleucine" EXACT RESID-name []
synonym: "N-acetylated L-isoleucine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 8 H 14 N 1 O 2"
xref: MassAvg: "156.20"
xref: MassMono: "156.102454"
xref: Origin: "I"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0204
is_a: MOD:00910 ! modified L-isoleucine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00057
name: N2-acetyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N2-acetyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, RESID:AA0048]
comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "(2S)-2-acetamido-6-aminohexanoic acid" EXACT RESID-systematic []
synonym: "2-acetylamino-6-aminohexanoic acid" EXACT RESID-alternate []
synonym: "2-acetylazanyl-6-azanylhexanoic acid" EXACT RESID-alternate []
synonym: "Acetyl" RELATED PSI-MS-label []
synonym: "N2-acetyl-L-lysine" EXACT RESID-name []
synonym: "N2-acetylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "N2-acetyllysine" EXACT RESID-alternate []
synonym: "N2AcLys" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 8 H 15 N 2 O 2"
xref: MassAvg: "171.22"
xref: MassMono: "171.113353"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00723 ! N-acetylated L-lysine
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00058
name: N-acetyl-L-methionine
def: "A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine." [PubMed:7944406, RESID:AA0049]
subset: PSI-MOD-slim
synonym: "(2S)-2-acetamido-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "2-acetylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate []
synonym: "2-acetylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate []
synonym: "2-acetylazanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate []
synonym: "acetylmethionine" EXACT RESID-alternate []
synonym: "AcMet" EXACT PSI-MOD-label []
synonym: "methionamine" EXACT RESID-alternate []
synonym: "MOD_RES N-acetylmethionine" EXACT UniProt-feature []
synonym: "N-acetyl-L-methionine" EXACT RESID-name []
synonym: "N-acetylated L-methionine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0"
xref: DiffMono: "42.010565"
xref: Formula: "C 7 H 12 N 1 O 2 S 1"
xref: MassAvg: "174.24"
xref: MassMono: "174.058875"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0205
is_a: MOD:00913 ! modified L-methionine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00059
name: N-acetyl-L-proline
def: "A protein modification that effectively converts an L-proline residue to N-acetyl-L-proline." [PubMed:2928307, RESID:AA0050]
subset: PSI-MOD-slim
synonym: "(2S)-1-acetyl-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic []
synonym: "1-acetylproline" EXACT RESID-alternate []
synonym: "acetylproline" EXACT RESID-alternate []
synonym: "MOD_RES N-acetylproline" EXACT UniProt-feature []
synonym: "N-acetyl-L-proline" EXACT RESID-name []
synonym: "N-acetylated L-proline" EXACT PSI-MOD-alternate []
synonym: "N-acetylproline" EXACT RESID-alternate []
synonym: "NAcPro" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 7 H 10 N 1 O 2"
xref: MassAvg: "140.16"
xref: MassMono: "140.071154"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0206
is_a: MOD:00915 ! modified L-proline residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00060
name: N-acetyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to N-acetyl-L-serine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:1880797, PubMed:2106685, PubMed:6997045, RESID:AA0051]
subset: PSI-MOD-slim
synonym: "(2S)-2-acetamido-3-hydroxypropanoic acid" EXACT RESID-systematic []
synonym: "2-acetylamino-3-hydroxypropanoic acid" EXACT RESID-alternate []
synonym: "2-acetylazanyl-3-hydroxypropanoic acid" EXACT RESID-alternate []
synonym: "Acetyl" RELATED PSI-MS-label []
synonym: "MOD_RES N-acetylserine" EXACT UniProt-feature []
synonym: "N-acetyl-L-serine" EXACT RESID-name []
synonym: "N-acetylated L-serine" EXACT PSI-MOD-alternate []
synonym: "N-acetylserine" EXACT RESID-alternate []
synonym: "NAcSer" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 5 H 8 N 1 O 3"
xref: MassAvg: "130.12"
xref: MassMono: "130.050418"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0207
is_a: MOD:00647 ! acetylated L-serine
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00061
name: N-acetyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to N-acetyl-L-threonine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:2106685, PubMed:6997045, RESID:AA0052]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-acetamido-3-hydroxybutanoic acid" EXACT RESID-systematic []
synonym: "2-acetylamino-3-hydroxybutanoic acid" EXACT RESID-alternate []
synonym: "2-acetylazanyl-3-hydroxybutanoic acid" EXACT RESID-alternate []
synonym: "Acetyl" RELATED PSI-MS-label []
synonym: "Acetylation" RELATED Unimod-description []
synonym: "MOD_RES N-acetylthreonine" EXACT UniProt-feature []
synonym: "N-acetyl-L-threonine" EXACT RESID-name []
synonym: "N-acetylated L-threonine" EXACT PSI-MOD-alternate []
synonym: "N-acetylthreonine" EXACT RESID-alternate []
synonym: "N-methylcarbonylthreonine" EXACT RESID-alternate []
synonym: "NAcThr" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 6 H 10 N 1 O 3"
xref: MassAvg: "144.15"
xref: MassMono: "144.066068"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0208
is_a: MOD:01186 ! acetylated L-threonine
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00062
name: N-acetyl-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to N-acetyl-L-tyrosine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:2506074, PubMed:475783, RESID:AA0053]
synonym: "(2S)-2-acetamido-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-acetylamino-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-alternate []
synonym: "2-acetylazanyl-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-alternate []
synonym: "Acetyl" RELATED PSI-MS-label []
synonym: "AcTyr" EXACT PSI-MOD-label []
synonym: "MOD_RES N-acetyltyrosine" EXACT UniProt-feature []
synonym: "N-acetyl-L-tyrosine" EXACT RESID-name []
synonym: "N-acetylated L-tyrosine" EXACT PSI-MOD-alternate []
synonym: "N-acetyltyrosine" EXACT RESID-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 11 H 12 N 1 O 3"
xref: MassAvg: "206.22"
xref: MassMono: "206.081718"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0209
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00063
name: N-acetyl-L-valine
def: "A protein modification that effectively converts an L-valine residue to N-acetyl-L-valine." [PubMed:1735421, RESID:AA0054]
subset: PSI-MOD-slim
synonym: "(2S)-2-acetamido-3-methylbutanoic acid" EXACT RESID-systematic []
synonym: "2-acetylamino-3-methylbutanoic acid" EXACT RESID-alternate []
synonym: "2-acetylazanyl-3-methylbutanoic acid" EXACT RESID-alternate []
synonym: "AcVal" EXACT PSI-MOD-label []
synonym: "MOD_RES N-acetylvaline" EXACT UniProt-feature []
synonym: "N-acetyl-L-valine" EXACT RESID-name []
synonym: "N-acetylated L-valine" EXACT PSI-MOD-alternate []
synonym: "N-acetylvaline" EXACT RESID-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 7 H 12 N 1 O 2"
xref: MassAvg: "142.18"
xref: MassMono: "142.086804"
xref: Origin: "V"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0210
is_a: MOD:00920 ! modified L-valine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00064
name: N6-acetyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine." [ChEBI:17752, DeltaMass:214, OMSSA:24, PubMed:11369851, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:1680872, PubMed:670159, RESID:AA0055, Unimod:1#K]
subset: PSI-MOD-slim
synonym: "(2S)-6-acetamido-2-aminohexanoic acid" EXACT RESID-systematic []
synonym: "6-acetylamino-2-aminohexanoic acid" EXACT RESID-alternate []
synonym: "6-acetylazanyl-2-aminohexanoic acid" EXACT RESID-alternate []
synonym: "Acetyl" RELATED PSI-MS-label []
synonym: "Acetylation" RELATED Unimod-description []
synonym: "acetylk" EXACT OMSSA-label []
synonym: "epsilon-acetyllysine" EXACT RESID-alternate []
synonym: "MOD_RES N6-acetyllysine" EXACT UniProt-feature []
synonym: "N(zeta)-acetyllysine" EXACT RESID-alternate []
synonym: "N6-acetyl-L-lysine" EXACT RESID-name []
synonym: "N6-acetylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "N6AcLys" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 8 H 14 N 2 O 2"
xref: MassAvg: "170.21"
xref: MassMono: "170.105528"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1"
xref: uniprot.ptm:PTM-0190
is_a: MOD:00723 ! N-acetylated L-lysine
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:00065
name: S-acetyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-acetyl-L-cysteine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:1310545, PubMed:14730666, PubMed:15350136, RESID:AA0056, Unimod:1#C]
subset: PSI-MOD-slim
synonym: "(2R)-3-acetylsulfanyl-2-aminopropanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(acetylthio)propanoic acid" EXACT RESID-alternate []
synonym: "2-azanyl-3-(acetylsulfanyl)propanoic acid" EXACT RESID-alternate []
synonym: "Acetyl" RELATED PSI-MS-label []
synonym: "Acetylation" RELATED Unimod-description []
synonym: "ACT_SITE S-acetylcysteine intermediate" EXACT UniProt-feature []
synonym: "cysteine acetate thioester" EXACT RESID-alternate []
synonym: "S-acetyl-L-cysteine" EXACT RESID-name []
synonym: "S-acetylcysteine" EXACT RESID-alternate []
synonym: "SAcCys" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0"
xref: DiffMono: "42.010565"
xref: Formula: "C 5 H 7 N 1 O 2 S 1"
xref: MassAvg: "145.18"
xref: MassMono: "145.019749"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1"
is_a: MOD:00645 ! mono S-acetylated residue
is_a: MOD:00646 ! monoacetylated L-cysteine

[Term]
id: MOD:00066
name: N-formylglycine
def: "A protein modification that effectively converts a glycine residue to N-formylglycine." [PubMed:5139483, RESID:AA0057]
synonym: "(formylamino)acetic acid" EXACT RESID-alternate []
synonym: "(formylamino)ethanoic acid" EXACT RESID-systematic []
synonym: "(formylazanyl)ethanoic acid" EXACT RESID-alternate []
synonym: "2-formamidoacetic acid" EXACT RESID-alternate []
synonym: "2-formamidoethanoic acid" EXACT RESID-alternate []
synonym: "MOD_RES N-formylglycine" EXACT UniProt-feature []
synonym: "N(alpha)-formylglycine" EXACT RESID-alternate []
synonym: "N-formylated glycine" EXACT PSI-MOD-alternate []
synonym: "N-formylglycine" EXACT RESID-name []
synonym: "NFoGly" EXACT PSI-MOD-label []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 H 0 N 0 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "C 3 H 4 N 1 O 2"
xref: MassAvg: "86.07"
xref: MassMono: "86.024203"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0211
is_a: MOD:00409 ! N-formylated residue
is_a: MOD:00908 ! modified glycine residue
is_a: MOD:01696 ! alpha-amino acylated residue

[Term]
id: MOD:00067
name: N-D-glucuronoylglycine
def: "A protein modification that effectively converts a glycine residue to N-D-glucuronoylglycine." [OMSSA:50, PubMed:10858503, PubMed:12716131, PubMed:6493057, PubMed:7398618, RESID:AA0058]
synonym: "2-(glucuronoylamino)ethanoic acid" EXACT RESID-systematic []
synonym: "Glucuronyl" RELATED PSI-MS-label []
synonym: "MOD_RES N-D-glucuronoyl glycine" EXACT UniProt-feature []
synonym: "N-D-glucuronoyl-glycine" EXACT RESID-name []
synonym: "N-D-glucuronyl-glycine" EXACT RESID-alternate []
synonym: "NGlcAGly" EXACT PSI-MOD-label []
synonym: "ntermpepglucuronylg" EXACT OMSSA-label []
xref: DiffAvg: "176.12"
xref: DiffFormula: "C 6 H 8 N 0 O 6"
xref: DiffMono: "176.032088"
xref: Formula: "C 8 H 12 N 1 O 7"
xref: MassAvg: "234.18"
xref: MassMono: "234.061377"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0331
is_a: MOD:00447 ! N-glucuronylated residue
is_a: MOD:00908 ! modified glycine residue

[Term]
id: MOD:00068
name: N-myristoylglycine
def: "A protein modification that effectively converts a glycine residue to N-myristoylglycine." [OMSSA:80, PubMed:11955007, PubMed:11955008, PubMed:1326520, PubMed:1386601, PubMed:6436247, PubMed:7543369, RESID:AA0059, Unimod:45#G]
subset: PSI-MOD-slim
synonym: "(tetradecanoylamino)ethanoic acid" EXACT RESID-systematic []
synonym: "LIPID N-myristoyl glycine" EXACT UniProt-feature []
synonym: "Myristoyl" RELATED PSI-MS-label []
synonym: "Myristoylation" RELATED Unimod-description []
synonym: "N-(1-oxotetradecyl)glycine" EXACT RESID-alternate []
synonym: "N-(C14:0 aliphatic acyl)glycine" EXACT PSI-MOD-alternate []
synonym: "N-myristoyl-glycine" EXACT RESID-name []
synonym: "N-myristoylated glycine" EXACT PSI-MOD-alternate []
synonym: "N-myristylglycine" EXACT RESID-alternate []
synonym: "N-tetradecanoylglycine" EXACT RESID-alternate []
synonym: "NMyrGly" EXACT PSI-MOD-label []
synonym: "ntermpepmyristoylationg" EXACT OMSSA-label []
xref: DiffAvg: "210.36"
xref: DiffFormula: "C 14 H 26 N 0 O 1"
xref: DiffMono: "210.198365"
xref: Formula: "C 16 H 30 N 1 O 2"
xref: MassAvg: "268.42"
xref: MassMono: "268.227654"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:45"
xref: uniprot.ptm:PTM-0221
is_a: MOD:00650 ! N-myristoylated residue
is_a: MOD:00908 ! modified glycine residue
is_a: MOD:01696 ! alpha-amino acylated residue

[Term]
id: MOD:00069
name: N-palmitoyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine." [PubMed:10896212, PubMed:4575979, PubMed:9056182, PubMed:9593755, RESID:AA0060]
comment: incidental to RESID:AA0107 incidental to RESID:AA0309
subset: PSI-MOD-slim
synonym: "(2R)-2-hexadecanoylamino-3-sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "2-hexadecanamido-3-sulfanylpropanoic acid" EXACT RESID-alternate []
synonym: "2-hexadecanoylamino-3-mercaptopropanoic acid" EXACT RESID-alternate []
synonym: "LIPID N-palmitoyl cysteine" EXACT UniProt-feature []
synonym: "N-(1-oxahexadecyl)-L-cysteine" EXACT RESID-alternate []
synonym: "N-palmitoyl-L-cysteine" EXACT RESID-name []
synonym: "N-palmitoylated L-cysteine" EXACT PSI-MOD-alternate []
synonym: "N-hexadecanoylated L-cysteine" EXACT PSI-MOD-alternate []
synonym: "NPamCys" EXACT PSI-MOD-label []
synonym: "Palmitoyl" RELATED PSI-MS-label []
synonym: "Palmitoylation" RELATED Unimod-description []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0"
xref: DiffMono: "238.229666"
xref: Formula: "C 19 H 36 N 1 O 2 S 1"
xref: MassAvg: "342.56"
xref: MassMono: "342.246675"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0222
is_a: MOD:01684 ! palmitoylated-L-cysteine
is_a: MOD:01685 ! alpha-amino palmitoylated residue

[Term]
id: MOD:00070
name: N-methyl-L-alanine
def: "A protein modification that effectively converts an L-alanine residue to N-methyl-L-alanine." [ChEBI:17519, PubMed:323502, PubMed:337304, PubMed:7007074, RESID:AA0061]
comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].
subset: PSI-MOD-slim
synonym: "(2S)-2-methylaminopropanoic acid" EXACT RESID-systematic []
synonym: "2-methylazanylpropanoic acid" EXACT RESID-alternate []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES N-methylalanine" EXACT UniProt-feature []
synonym: "N-methyl-L-alanine" EXACT RESID-name []
synonym: "N-methylalanine" EXACT RESID-alternate []
synonym: "N-methylated L-alanine" EXACT PSI-MOD-alternate []
synonym: "NMe1Ala" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 4 H 7 N 1 O 1"
xref: MassAvg: "85.11"
xref: MassMono: "85.052764"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0214
is_a: MOD:01461 ! N-methylated alanine
is_a: MOD:01680 ! alpha-amino monomethylated residue

[Term]
id: MOD:00071
name: N,N,N-trimethyl-L-alanine
def: "A protein modification that effectively converts an L-alanine residue to N,N,N-trimethyl-L-alanine." [PubMed:12590383, PubMed:332162, PubMed:3979397, PubMed:6778808, PubMed:7715456, RESID:AA0062]
subset: PSI-MOD-slim
synonym: "(1S)-1-carboxy-N,N,N-trimethylethanaminium" EXACT RESID-systematic []
synonym: "(1S)-1-carboxy-N,N,N-trimethylethanazanium" EXACT RESID-alternate []
synonym: "(2S)-2-(trimethylammonio)propanoic acid" EXACT RESID-alternate []
synonym: "MOD_RES N,N,N-trimethylalanine" EXACT UniProt-feature []
synonym: "N,N,N-trimethyl-L-alanine" EXACT RESID-name []
synonym: "N,N,N-trimethylalanine cation" EXACT RESID-alternate []
synonym: "N,N,N-trimethylalaninium" EXACT RESID-alternate []
synonym: "N,N,N-trimethylated L-alanine" EXACT PSI-MOD-alternate []
synonym: "N2Me3+Ala" EXACT PSI-MOD-label []
synonym: "NMe3Ala" EXACT PSI-MOD-label []
synonym: "tri-Methylation" RELATED Unimod-description []
synonym: "Trimethyl" RELATED PSI-MS-label []
xref: DiffAvg: "43.09"
xref: DiffFormula: "C 3 H 7 N 0 O 0"
xref: DiffMono: "43.054227"
xref: FormalCharge: "1+"
xref: Formula: "C 6 H 13 N 1 O 1"
xref: MassAvg: "115.18"
xref: MassMono: "115.099165"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0177
is_a: MOD:01461 ! N-methylated alanine
is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue

[Term]
id: MOD:00072
name: N-methylglycine
def: "A protein modification that effectively converts a glycine residue to N-methylglycine." [ChEBI:15611, DeltaMass:0, PubMed:1593629, RESID:AA0063]
comment: DeltaMass also has an entry for the free amino acid. Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].
synonym: "L-sarcosine" EXACT RESID-alternate []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "methylaminoacetic acid" EXACT RESID-alternate []
synonym: "methylaminoethanoic acid" EXACT RESID-systematic []
synonym: "Methylation" RELATED Unimod-description []
synonym: "N-methylated glycine" EXACT PSI-MOD-alternate []
synonym: "N-methylglycine" EXACT RESID-name []
synonym: "NMe1Gly" EXACT PSI-MOD-label []
synonym: "Sar" EXACT DeltaMass-label []
synonym: "Sarcosine" EXACT DeltaMass-label []
synonym: "Sarcosyl" EXACT DeltaMass-label []
synonym: "MOD_RES N-methylglycine" EXACT UniProt-feature []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 3 H 5 N 1 O 1"
xref: MassAvg: "71.08"
xref: MassMono: "71.037114"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0483
is_a: MOD:00570 ! residues isobaric at 71.037114 Da
is_a: MOD:00714 ! methylated glycine
is_a: MOD:01680 ! alpha-amino monomethylated residue

[Term]
id: MOD:00073
name: N-methyl-L-methionine
def: "A protein modification that effectively converts an L-methionine residue to N-methyl-L-methionine." [DeltaMass:169, PubMed:323502, PubMed:3298225, RESID:AA0064]
comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].
subset: PSI-MOD-slim
synonym: "(2S)-2-methylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "2-methylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methyl Methionyl" EXACT DeltaMass-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES N-methylmethionine" EXACT UniProt-feature []
synonym: "N-methyl-L-methionine" EXACT RESID-name []
synonym: "N-methylated L-methionine" EXACT PSI-MOD-alternate []
synonym: "N-methylmethionine" EXACT RESID-alternate []
synonym: "NMe1Met" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 6 H 11 N 1 O 1 S 1"
xref: MassAvg: "145.22"
xref: MassMono: "145.056135"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0217
is_a: MOD:01463 ! N-methylated methionine
is_a: MOD:01680 ! alpha-amino monomethylated residue

[Term]
id: MOD:00074
name: N-methyl-L-phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to N-methyl-L-phenylalanine." [PubMed:2577730, PubMed:413571, RESID:AA0065]
comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].
subset: PSI-MOD-slim
synonym: "(2S)-2-methylamino-3-phenylpropanoic acid" EXACT RESID-systematic []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES N-methylphenylalanine" EXACT UniProt-feature []
synonym: "N-methyl-L-phenylalanine" EXACT RESID-name []
synonym: "N-methylated L-phenylalanine" EXACT PSI-MOD-alternate []
synonym: "N-methylphenylalanine" EXACT RESID-alternate []
synonym: "NMe1Phe" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 10 H 11 N 1 O 1"
xref: MassAvg: "161.20"
xref: MassMono: "161.084064"
xref: Origin: "F"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0218
is_a: MOD:01063 ! monomethylated phenylalanine
is_a: MOD:01680 ! alpha-amino monomethylated residue

[Term]
id: MOD:00075
name: N,N-dimethyl-L-proline
def: "A protein modification that effectively converts an L-proline residue to N,N-dimethyl-L-proline." [ChEBI:21451, PubMed:12964758, PubMed:14570711, PubMed:193025, PubMed:3882426, PubMed:6254758, RESID:AA0066, Unimod:529]
comment: Unimod terminal specification corrected [JSG].
subset: PSI-MOD-slim
synonym: "(2S)-2-carboxy-1,1-dimethylpyrrolidinium" EXACT RESID-systematic []
synonym: "1,1-dimethyl-L-prolinium" EXACT RESID-alternate []
synonym: "Delta:H(5)C(2)" RELATED Unimod-interim []
synonym: "Dimethyl" RELATED PSI-MS-label []
synonym: "Dimethylation of proline residue" RELATED Unimod-description []
synonym: "MOD_RES N,N-dimethylproline" EXACT UniProt-feature []
synonym: "N,N-dimethyl-L-proline" EXACT RESID-name []
synonym: "N,N-dimethyl-L-prolinium" EXACT RESID-alternate []
synonym: "N,N-dimethylated L-proline" EXACT PSI-MOD-alternate []
synonym: "NMe2Pro" EXACT PSI-MOD-label []
synonym: "stachydrin" EXACT RESID-alternate []
xref: DiffAvg: "29.06"
xref: DiffFormula: "C 2 H 5 N 0 O 0"
xref: DiffMono: "29.038577"
xref: FormalCharge: "1+"
xref: Formula: "C 7 H 13 N 1 O 1"
xref: MassAvg: "127.19"
xref: MassMono: "127.099165"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:529"
xref: uniprot.ptm:PTM-0179
is_a: MOD:00710 ! protonated-dimethylated residue
is_a: MOD:01462 ! N-methylated proline

[Term]
id: MOD:00076
name: symmetric dimethyl-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine." [PubMed:12964758, PubMed:14570711, PubMed:15835918, PubMed:2426402, PubMed:5128665, RESID:AA0067, Unimod:36#R]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-[((methylamino)(methylimino)methyl)amino]pentanoic acid" EXACT RESID-systematic []
synonym: "di-Methylation" RELATED Unimod-description []
synonym: "Dimethyl" RELATED PSI-MS-label []
synonym: "MOD_RES Omega-N-methylated arginine" EXACT UniProt-feature []
synonym: "MOD_RES Symmetric dimethylarginine" EXACT UniProt-feature []
synonym: "N3,N4-dimethylarginine" EXACT RESID-alternate []
synonym: "N5-[(methylamino)(methylimino)methyl]ornithine" EXACT RESID-alternate []
synonym: "NG,N'G-dimethylarginine" EXACT RESID-alternate []
synonym: "NoNo'Me2Arg" EXACT PSI-MOD-label []
synonym: "omega-N,omega-N'-dimethyl-L-arginine" EXACT RESID-name []
synonym: "omega-N,omega-N'-dimethylated L-arginine" EXACT PSI-MOD-alternate []
synonym: "symmetric dimethylarginine" EXACT RESID-alternate []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4 N 0 O 0"
xref: DiffMono: "28.031300"
xref: Formula: "C 8 H 16 N 4 O 1"
xref: MassAvg: "184.24"
xref: MassMono: "184.132411"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:36"
xref: uniprot.ptm:PTM-0287
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:00783 ! dimethylated L-arginine

[Term]
id: MOD:00077
name: asymmetric dimethyl-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to asymmetric dimethylarginine, N(omega),N(omega)-dimethyl-L-arginine." [ChEBI:17929, PubMed:11152131, PubMed:12964758, PubMed:14570711, PubMed:15835918, PubMed:3032834, RESID:AA0068, Unimod:36#R]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid" EXACT RESID-systematic []
synonym: "asymmetric dimethylarginine" EXACT RESID-alternate []
synonym: "di-Methylation" RELATED Unimod-description []
synonym: "Dimethyl" RELATED PSI-MS-label []
synonym: "MOD_RES Asymmetric dimethylarginine" EXACT UniProt-feature []
synonym: "MOD_RES Omega-N-methylated arginine" EXACT UniProt-feature []
synonym: "N5-[(dimethylamino)(imino)methyl]ornithine" EXACT RESID-alternate []
synonym: "NG,NG-dimethylarginine" EXACT RESID-alternate []
synonym: "NoNoMe2Arg" EXACT PSI-MOD-label []
synonym: "omega-N,omega-N-dimethlyated L-arginine" EXACT PSI-MOD-alternate []
synonym: "omega-N,omega-N-dimethyl-L-arginine" EXACT RESID-name []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4 N 0 O 0"
xref: DiffMono: "28.031300"
xref: Formula: "C 8 H 16 N 4 O 1"
xref: MassAvg: "184.24"
xref: MassMono: "184.132411"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:36"
xref: uniprot.ptm:PTM-0066
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:00783 ! dimethylated L-arginine

[Term]
id: MOD:00078
name: omega-N-methyl-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine." [PubMed:11875433, PubMed:15835918, PubMed:2426402, PubMed:5128665, RESID:AA0069]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-[(imino(methylamino)methyl)amino]pentanoic acid" EXACT RESID-systematic []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES Omega-N-methylarginine" EXACT UniProt-feature []
synonym: "MOD_RES Omega-N-methylated arginine" EXACT UniProt-feature []
synonym: "NG-methylarginine" EXACT RESID-alternate []
synonym: "NoMeArg" EXACT PSI-MOD-label []
synonym: "omega-N-methyl-L-arginine" EXACT RESID-name []
synonym: "omega-N-methylated L-arginine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 14 N 4 O 1"
xref: MassAvg: "170.22"
xref: MassMono: "170.116761"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0237
is_a: MOD:00414 ! monomethylated L-arginine
is_a: MOD:00602 ! N-methylated residue

[Term]
id: MOD:00079
name: N4-methyl-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to N4-methyl-L-asparagine." [OMSSA:75, PubMed:11875433, PubMed:2356973, PubMed:3782095, RESID:AA0070, Unimod:34#N]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-N4-methylbutanediamic acid" EXACT RESID-systematic []
synonym: "beta-aspartyl methylamide" EXACT RESID-alternate []
synonym: "beta-methylasparagine" RELATED RESID-misnomer []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "methyln" EXACT OMSSA-label []
synonym: "MOD_RES N4-methylasparagine" EXACT UniProt-feature []
synonym: "N(gamma)-methylasparagine" EXACT RESID-alternate []
synonym: "N-methylasparagine" EXACT RESID-alternate []
synonym: "N4-methyl-L-asparagine" EXACT RESID-name []
synonym: "N4-methylated L-asparagine" EXACT PSI-MOD-alternate []
synonym: "N4Me1Asn" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 5 H 8 N 2 O 2"
xref: MassAvg: "128.13"
xref: MassMono: "128.058578"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
xref: uniprot.ptm:PTM-0183
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:00673 ! methylated asparagine
is_a: MOD:00894 ! residues isobaric at 128.058578 Da

[Term]
id: MOD:00080
name: N5-methyl-L-glutamine
def: "A protein modification that effectively converts an L-glutamine residue to N5-methyl-L-glutamine." [ChEBI:17592, DeltaMass:166, PubMed:11118225, PubMed:11875433, PubMed:365579, RESID:AA0071]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-methylamino-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "2-amino-N5-methylpentanediamic acid" EXACT RESID-alternate []
synonym: "gamma-methylglutamine" EXACT RESID-alternate []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES N5-methylglutamine" EXACT UniProt-feature []
synonym: "N(delta)-methylglutamine" EXACT RESID-alternate []
synonym: "N-methylglutamine" EXACT RESID-alternate []
synonym: "N5-methyl-L-glutamine" EXACT RESID-name []
synonym: "N5-methylated L-glutamine" EXACT PSI-MOD-alternate []
synonym: "N5Me1Gln" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 6 H 10 N 2 O 2"
xref: MassAvg: "142.16"
xref: MassMono: "142.074228"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0185
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:00722 ! monomethylated L-glutamine

[Term]
id: MOD:00081
name: L-glutamic acid 5-methyl ester (Glu)
def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-methyl ester." [DeltaMass:167, OMSSA:17, OMSSA:70, PubMed:16888, PubMed:6300110, RESID:AA0072#GLU, Unimod:34#E]
comment: DeltaMass gives the formula "C 6 H 9 O 1 N 3" with mass 143 (formula incorrect, N and O reversed) [JSG].
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-methoxy-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "(5)-methyl L-hydrogen glutamate" EXACT RESID-alternate []
synonym: "2-aminopentanedioic acid 5-methyl ester" EXACT RESID-alternate []
synonym: "5-methyl esterified L-glutamic acid" EXACT PSI-MOD-alternate []
synonym: "5-methyl L-2-aminoglutarate" EXACT RESID-alternate []
synonym: "5-methyl L-glutamate" EXACT RESID-alternate []
synonym: "glutamic acid 5-methyl ester" EXACT RESID-alternate []
synonym: "glutamic acid gamma-methyl ester" EXACT RESID-alternate []
synonym: "L-glutamic acid 5-methyl ester" EXACT RESID-name []
synonym: "meestere" EXACT OMSSA-label []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "methyl ester" RELATED Unimod-alternate []
synonym: "Methylation" RELATED Unimod-description []
synonym: "methyle" EXACT OMSSA-label []
synonym: "MOD_RES Glutamate methyl ester (Glu)" EXACT UniProt-feature []
synonym: "O-methyl Glutamyl" EXACT DeltaMass-label []
synonym: "O5MeGlu" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 6 H 9 N 1 O 3"
xref: MassAvg: "143.14"
xref: MassMono: "143.058243"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
xref: uniprot.ptm:PTM-0128
is_a: MOD:01453 ! L-glutamic acid 5-methyl ester

[Term]
id: MOD:00082
name: 3'-methyl-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to pros-methyl-L-histidine (N-pi-methyl-L-histidine, 3'-methyl-L-histidine)." [PubMed:10660523, PubMed:11875433, PubMed:3467365, PubMed:6692818, PubMed:8076, PubMed:8645219, RESID:AA0073]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(3-methyl-3H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic []
synonym: "1-methylhistidine" RELATED RESID-misnomer []
synonym: "3'-methyl-L-histidine" EXACT RESID-name []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES Pros-methylhistidine" EXACT UniProt-feature []
synonym: "N(delta)-methylhistidine" EXACT RESID-alternate []
synonym: "N(pi)-methylhistidine" EXACT RESID-alternate []
synonym: "NpMeHis" EXACT PSI-MOD-label []
synonym: "pros-methylated L-histidine" EXACT PSI-MOD-alternate []
synonym: "pros-methylhistidine" EXACT RESID-alternate []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 9 N 3 O 1"
xref: MassAvg: "151.17"
xref: MassMono: "151.074562"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0259
is_a: MOD:02038 ! monomethylated L-histidine
is_a: MOD:00724 ! N-methylated L-histidine

[Term]
id: MOD:00083
name: N6,N6,N6-trimethyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine." [ChEBI:17311, PubMed:12590383, PubMed:3145979, PubMed:4304194, PubMed:6778808, PubMed:7093227, PubMed:8453381, RESID:AA0074]
comment: DeltaMass calculates the mass difference from protonated lysine rather than neutral lysine; for trimethylated lysine starting from protonated lysine see MOD:00855
subset: PSI-MOD-slim
synonym: "(5S)-5-amino-5-carboxy-N,N,N-trimethylpentan-1-aminium" EXACT RESID-systematic []
synonym: "2-amino-6-(trimethylammonio)hexanoic acid" EXACT RESID-alternate []
synonym: "5-azanyl-5-carboxy-N,N,N-trimethylpentanazanium" EXACT RESID-alternate []
synonym: "epsilon-trimethyllysine" EXACT RESID-alternate []
synonym: "MOD_RES N6,N6,N6-trimethyllysine" EXACT UniProt-feature []
synonym: "N(zeta)-trimethyllysine" EXACT RESID-alternate []
synonym: "N-trimethylation (of lysine)" EXACT DeltaMass-label []
synonym: "N6,N6,N6-trimethyl-L-lysine" EXACT RESID-name []
synonym: "N6,N6,N6-trimethylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "N6,N6,N6-trimethyllysin-N6-ium" EXACT RESID-alternate []
synonym: "N6,N6,N6-trimethyllysine cation" EXACT RESID-alternate []
synonym: "N6Me3+Lys" EXACT PSI-MOD-label []
synonym: "tri-Methylation" RELATED Unimod-description []
synonym: "Trimethyl" RELATED PSI-MS-label []
xref: DiffAvg: "43.09"
xref: DiffFormula: "C 3 H 7 N 0 O 0"
xref: DiffMono: "43.054227"
xref: FormalCharge: "1+"
xref: Formula: "C 9 H 19 N 2 O 1"
xref: MassAvg: "171.26"
xref: MassMono: "171.149190"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0187
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:00663 ! methylated lysine
is_a: MOD:00711 ! trimethylated protonated-residue

[Term]
id: MOD:00084
name: N6,N6-dimethyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine." [OMSSA:36, PubMed:10550045, PubMed:12964758, PubMed:14570711, PubMed:3100523, PubMed:8453381, RESID:AA0075, Unimod:36#K]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-(dimethylamino)hexanoic acid" EXACT RESID-systematic []
synonym: "di-Methylation" RELATED Unimod-description []
synonym: "Dimethyl" RELATED PSI-MS-label []
synonym: "dimethylk" EXACT OMSSA-label []
synonym: "epsilon-dimethyllysine" EXACT RESID-alternate []
synonym: "lysine derivative Lys(y)" EXACT RESID-alternate []
synonym: "MOD_RES N6,N6-dimethyllysine" EXACT UniProt-feature []
synonym: "N(zeta)-dimethyllysine" EXACT RESID-alternate []
synonym: "N6,N6-dimethyl-L-lysine" EXACT RESID-name []
synonym: "N6,N6-dimethylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "N6Me2Lys" EXACT PSI-MOD-label []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4 N 0 O 0"
xref: DiffMono: "28.031300"
xref: Formula: "C 8 H 16 N 2 O 1"
xref: MassAvg: "156.23"
xref: MassMono: "156.126263"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:36"
xref: uniprot.ptm:PTM-0188
is_a: MOD:00429 ! dimethylated residue
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:00663 ! methylated lysine

[Term]
id: MOD:00085
name: N6-methyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine." [ChEBI:17604, DeltaMass:165, PubMed:11875433, PubMed:3926756, RESID:AA0076, Unimod:34#K]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-methylaminohexanoic acid" EXACT RESID-systematic []
synonym: "epsilon-methyllysine" EXACT RESID-alternate []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES N6-methyllysine" EXACT UniProt-feature []
synonym: "N(zeta)-methyllysine" EXACT RESID-alternate []
synonym: "N-methyl Lysyl" EXACT DeltaMass-label []
synonym: "N6-methyl-L-lysine" EXACT RESID-name []
synonym: "N6-methylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "N6Me1Lys" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 14 N 2 O 1"
xref: MassAvg: "142.20"
xref: MassMono: "142.110613"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
xref: uniprot.ptm:PTM-0194
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:01683 ! monomethylated L-lysine

[Term]
id: MOD:00086
name: N6-palmitoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-palmitoyl-L-lysine." [OMSSA:93, PubMed:2498336, PubMed:7801126, PubMed:7939682, RESID:AA0077, Unimod:47#K]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-(hexadecanoylamino)hexanoic acid" EXACT RESID-systematic []
synonym: "2-amino-6-(hexadecanamido)hexanoic acid" EXACT RESID-alternate []
synonym: "epsilon-palmitoyllysine" EXACT RESID-alternate []
synonym: "LIPID N6-palmitoyl lysine" EXACT UniProt-feature []
synonym: "N(zeta)-palmitoyllysine" EXACT RESID-alternate []
synonym: "N6-(1-oxohexadecyl)-L-lysine" EXACT RESID-alternate []
synonym: "N6-palmitoyl-L-lysine" EXACT RESID-name []
synonym: "N6-palmitoylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "N6-hexadecanoylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "N6PamLys" EXACT PSI-MOD-label []
synonym: "Palmitoyl" RELATED PSI-MS-label []
synonym: "Palmitoylation" RELATED Unimod-description []
synonym: "palmitoylationk" EXACT OMSSA-label []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 N 0 O 1"
xref: DiffMono: "238.229666"
xref: Formula: "C 22 H 42 N 2 O 2"
xref: MassAvg: "366.59"
xref: MassMono: "366.324629"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:47"
xref: uniprot.ptm:PTM-0197
is_a: MOD:00651 ! N-palmitoylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:00087
name: N6-myristoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine." [OMSSA:81, PubMed:1402651, PubMed:8346241, RESID:AA0078, Unimod:45#K]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-(tetradecanoylamino)hexanoic acid" EXACT RESID-systematic []
synonym: "2-amino-6-(tetradecanamido)hexanoic acid" EXACT RESID-alternate []
synonym: "epsilon-myristoyllysine" EXACT RESID-alternate []
synonym: "LIPID N6-myristoyl lysine" EXACT UniProt-feature []
synonym: "Myristoyl" RELATED PSI-MS-label []
synonym: "Myristoylation" RELATED Unimod-description []
synonym: "myristoylationk" EXACT OMSSA-label []
synonym: "N(zeta)-myristoyllysine" EXACT RESID-alternate []
synonym: "N6-(1-oxotetradecyl)-L-lysine" EXACT RESID-alternate []
synonym: "N6-(C14:0 aliphatic acyl)lysine" EXACT PSI-MOD-alternate []
synonym: "N6-myristoyl-L-lysine" EXACT RESID-name []
synonym: "N6-myristoylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "N6MyrLys" EXACT PSI-MOD-label []
xref: DiffAvg: "210.36"
xref: DiffFormula: "C 14 H 26 N 0 O 1"
xref: DiffMono: "210.198365"
xref: Formula: "C 20 H 38 N 2 O 2"
xref: MassAvg: "338.54"
xref: MassMono: "338.293328"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:45"
xref: uniprot.ptm:PTM-0196
is_a: MOD:00650 ! N-myristoylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:00088
name: O-palmitoyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine." [OMSSA:95, PubMed:6642431, PubMed:8413602, RESID:AA0079, Unimod:47#T]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-(hexadecanoyloxy)butanoic acid" EXACT RESID-systematic []
synonym: "L-threonine hexadecanoate ester" EXACT RESID-alternate []
synonym: "LIPID O-palmitoyl threonine" EXACT UniProt-feature []
synonym: "O-palmitoyl-L-threonine" EXACT RESID-name []
synonym: "O-palmitoylated L-threonine" EXACT PSI-MOD-alternate []
synonym: "O-hexadecanoylated L-threonine" EXACT PSI-MOD-alternate []
synonym: "O3-palmitoyl-threonine" EXACT RESID-alternate []
synonym: "OPamThr" EXACT PSI-MOD-label []
synonym: "Palmitoyl" RELATED PSI-MS-label []
synonym: "Palmitoylation" RELATED Unimod-description []
synonym: "palmitoylationt" EXACT OMSSA-label []
synonym: "threonine palmitate ester" EXACT RESID-alternate []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 N 0 O 1"
xref: DiffMono: "238.229666"
xref: Formula: "C 20 H 37 N 1 O 3"
xref: MassAvg: "339.52"
xref: MassMono: "339.277344"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:47"
xref: uniprot.ptm:PTM-0242
is_a: MOD:00652 ! O-palmitoylated residue
is_a: MOD:02004 ! O3-acylated L-threonine

[Term]
id: MOD:00089
name: O-palmitoyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-palmitoyl-L-serine." [OMSSA:94, PubMed:3467339, RESID:AA0080, Unimod:47#S]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(hexadecanoyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "ACT_SITE O-palmitoyl serine intermediate" EXACT UniProt-feature []
synonym: "L-serine hexadecanoate ester" EXACT RESID-alternate []
synonym: "LIPID O-palmitoyl serine" EXACT UniProt-feature []
synonym: "O-palmitoyl-L-serine" EXACT RESID-name []
synonym: "O-palmitoylated L-serine" EXACT PSI-MOD-alternate []
synonym: "O-hexadecanoylated L-serine" EXACT PSI-MOD-alternate []
synonym: "O3-palmitoyl-serine" EXACT RESID-alternate []
synonym: "OPamSer" EXACT PSI-MOD-label []
synonym: "Palmitoyl" RELATED PSI-MS-label []
synonym: "Palmitoylation" RELATED Unimod-description []
synonym: "palmitoylations" EXACT OMSSA-label []
synonym: "serine palmitate ester" EXACT RESID-alternate []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 N 0 O 1"
xref: DiffMono: "238.229666"
xref: Formula: "C 19 H 35 N 1 O 3"
xref: MassAvg: "325.49"
xref: MassMono: "325.261694"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:47"
xref: uniprot.ptm:PTM-0241
is_a: MOD:00652 ! O-palmitoylated residue
is_a: MOD:02003 ! O3-acylated L-serine

[Term]
id: MOD:00090
name: L-alanine amide
def: "A protein modification that effectively converts an L-alanine residue to L-alanine amide." [PubMed:1377792, PubMed:2069951, PubMed:8472537, PubMed:952951, RESID:AA0081]
subset: PSI-MOD-slim
synonym: "(2S)-2-aminopropanamide" EXACT RESID-systematic []
synonym: "AlaN" EXACT PSI-MOD-label []
synonym: "alaninamide" EXACT RESID-alternate []
synonym: "amidated L-alanine" EXACT PSI-MOD-alternate []
synonym: "L-alanine amide" EXACT RESID-name []
synonym: "MOD_RES Alanine amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 3 H 7 N 2 O 1"
xref: MassAvg: "87.10"
xref: MassMono: "87.055838"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0057
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00901 ! modified L-alanine residue

[Term]
id: MOD:00091
name: L-arginine amide
def: "A protein modification that effectively converts an L-arginine residue to L-arginine amide." [PubMed:2229025, PubMed:2753890, PubMed:743209, RESID:AA0082, ChEBI:145897]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-[(diaminomethylidene)amino]pentanamide" EXACT RESID-systematic []
synonym: "2-amino-5-carbamimidamidopentanamide" EXACT RESID-alternate []
synonym: "2-amino-5-guanidinopentanamide" EXACT RESID-alternate []
synonym: "amidated L-arginine" EXACT PSI-MOD-alternate []
synonym: "argininamide" EXACT RESID-alternate []
synonym: "ArgN" EXACT PSI-MOD-label []
synonym: "L-arginine amide" EXACT RESID-name []
synonym: "MOD_RES Arginine amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 6 H 14 N 5 O 1"
xref: MassAvg: "172.21"
xref: MassMono: "172.119835"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0060
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00092
name: L-asparagine amide
def: "A protein modification that effectively converts an L-asparagine residue to L-asparagine amide." [PubMed:2753132, PubMed:279902, PubMed:3415690, RESID:AA0083, ChEBI:145898]
subset: PSI-MOD-slim
synonym: "(2S)-2-aminobutanediamide" EXACT RESID-systematic []
synonym: "amidated L-asparagine" EXACT PSI-MOD-alternate []
synonym: "AsnN" EXACT PSI-MOD-label []
synonym: "asparaginamide" EXACT RESID-alternate []
synonym: "L-asparagine amide" EXACT RESID-name []
synonym: "MOD_RES Asparagine amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 4 H 8 N 3 O 2"
xref: MassAvg: "130.13"
xref: MassMono: "130.061652"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0062
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:00093
name: L-aspartic acid 1-amide
def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartic acid 1-amide." [PubMed:2542051, RESID:AA0084]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-1-butanediamic acid" EXACT RESID-systematic []
synonym: "1-amidated L-aspartic acid" EXACT PSI-MOD-alternate []
synonym: "3,4-diamino-4-oxobutanoic acid" EXACT RESID-alternate []
synonym: "3-amino-succinamic acid" EXACT RESID-alternate []
synonym: "alpha-asparagine" EXACT RESID-alternate []
synonym: "AspN" EXACT PSI-MOD-label []
synonym: "isoasparagine" EXACT RESID-alternate []
synonym: "L-aspartic acid 1-amide" EXACT RESID-name []
synonym: "MOD_RES Aspartic acid 1-amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 4 H 7 N 2 O 3"
xref: MassAvg: "131.11"
xref: MassMono: "131.045667"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0063
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:00094
name: L-cysteine amide
def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine amide." [PubMed:1892838, PubMed:7149738, RESID:AA0085]
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-sulfanylpropanamide" EXACT RESID-systematic []
synonym: "2-amino-3-mercaptopropanamide" EXACT RESID-alternate []
synonym: "amidated L-cysteine" EXACT PSI-MOD-alternate []
synonym: "CysN" EXACT PSI-MOD-label []
synonym: "cysteinamide" EXACT RESID-alternate []
synonym: "L-cysteine amide" EXACT RESID-name []
synonym: "MOD_RES Cysteine amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1 S 0"
xref: DiffMono: "-0.984016"
xref: Formula: "C 3 H 7 N 2 O 1 S 1"
xref: MassAvg: "119.16"
xref: MassMono: "119.027909"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0102
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00095
name: L-glutamine amide
def: "A protein modification that effectively converts an L-glutamine residue to L-glutamine amide." [PubMed:7673220, PubMed:9048550, RESID:AA0086]
subset: PSI-MOD-slim
synonym: "(2S)-2-aminopentanediamide" EXACT RESID-systematic []
synonym: "amidated L-glutamine" EXACT PSI-MOD-alternate []
synonym: "GlnN" EXACT PSI-MOD-label []
synonym: "glutaminamide" EXACT RESID-alternate []
synonym: "L-glutamine amide" EXACT RESID-name []
synonym: "MOD_RES Glutamine amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 5 H 10 N 3 O 2"
xref: MassAvg: "144.15"
xref: MassMono: "144.077302"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0130
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00907 ! modified L-glutamine residue

[Term]
id: MOD:00096
name: L-glutamic acid 1-amide
def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamic acid 1-amide." [PubMed:1093875, PubMed:14550575, RESID:AA0087]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-1-pentanediamic acid" EXACT RESID-systematic []
synonym: "1-amidated L-glutamic acid" EXACT PSI-MOD-alternate []
synonym: "4,5-diamino-5-oxopentanoic acid" EXACT RESID-alternate []
synonym: "GluN" EXACT PSI-MOD-label []
synonym: "isoglutamine" EXACT RESID-alternate []
synonym: "L-glutamic acid 1-amide" EXACT RESID-name []
synonym: "MOD_RES Glutamic acid 1-amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 5 H 9 N 2 O 3"
xref: MassAvg: "145.14"
xref: MassMono: "145.061317"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0129
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:00097
name: glycine amide
def: "A protein modification that effectively converts a glycine residue to glycine amide." [PubMed:13591312, RESID:AA0088]
subset: PSI-MOD-slim
synonym: "2-aminoacetamide" EXACT RESID-alternate []
synonym: "2-aminoethanamide" EXACT RESID-systematic []
synonym: "2-azanylethanamide" EXACT RESID-alternate []
synonym: "amidated glycine" EXACT PSI-MOD-alternate []
synonym: "glycinamide" EXACT RESID-alternate []
synonym: "glycine amide" EXACT RESID-name []
synonym: "GlyN" EXACT PSI-MOD-label []
synonym: "MOD_RES Glycine amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 2 H 5 N 2 O 1"
xref: MassAvg: "73.07"
xref: MassMono: "73.040188"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0132
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00908 ! modified glycine residue

[Term]
id: MOD:00098
name: L-histidine amide
def: "A protein modification that effectively converts an L-histidine residue to L-histidine amide." [PubMed:2153586, PubMed:2307683, PubMed:2839478, RESID:AA0089]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(1H-imidazol-4-yl)propanamide" EXACT RESID-systematic []
synonym: "amidated L-histidine" EXACT PSI-MOD-alternate []
synonym: "HisN" EXACT PSI-MOD-label []
synonym: "histidinamide" EXACT RESID-alternate []
synonym: "L-histidine amide" EXACT RESID-name []
synonym: "MOD_RES Histidine amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 6 H 9 N 4 O 1"
xref: MassAvg: "153.16"
xref: MassMono: "153.077636"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0148
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:00099
name: L-isoleucine amide
def: "A protein modification that effectively converts an L-isoleucine residue to L-isoleucine amide." [RESID:AA0090]
subset: PSI-MOD-slim
synonym: "(2S,3S)-2-amino-3-methylpentanamide" EXACT RESID-systematic []
synonym: "amidated L-isoleucine" EXACT PSI-MOD-alternate []
synonym: "IleN" EXACT PSI-MOD-label []
synonym: "isoleucinamide" EXACT RESID-alternate []
synonym: "L-isoleucine amide" EXACT RESID-name []
synonym: "MOD_RES Isoleucine amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 6 H 13 N 2 O 1"
xref: MassAvg: "129.18"
xref: MassMono: "129.102788"
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0161
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00910 ! modified L-isoleucine residue

[Term]
id: MOD:00100
name: L-leucine amide
def: "A protein modification that effectively converts an L-leucine residue to L-leucine amide." [PubMed:2578459, RESID:AA0091]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-4-methylpentanamide" EXACT RESID-systematic []
synonym: "2-amino-4-methylvaleramide" EXACT RESID-alternate []
synonym: "2-azanyl-4-methylpentanamide" EXACT RESID-alternate []
synonym: "alpha-aminoisocaproamide" EXACT RESID-alternate []
synonym: "amidated L-leucine" EXACT PSI-MOD-alternate []
synonym: "L-leucine amide" EXACT RESID-name []
synonym: "leucinamide" EXACT RESID-alternate []
synonym: "LeuN" EXACT PSI-MOD-label []
synonym: "MOD_RES Leucine amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 6 H 13 N 2 O 1"
xref: MassAvg: "129.18"
xref: MassMono: "129.102788"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0166
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00911 ! modified L-leucine residue

[Term]
id: MOD:00101
name: L-lysine amide
def: "A protein modification that effectively converts an L-lysine residue to L-lysine amide." [PubMed:6579533, RESID:AA0092]
subset: PSI-MOD-slim
synonym: "(2S)-2,6-diaminohexanamide" EXACT RESID-systematic []
synonym: "amidated L-lysine" EXACT PSI-MOD-alternate []
synonym: "L-lysine amide" EXACT RESID-name []
synonym: "lysinamide" EXACT RESID-alternate []
synonym: "LysN" EXACT PSI-MOD-label []
synonym: "MOD_RES Lysine amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 6 H 14 N 3 O 1"
xref: MassAvg: "144.20"
xref: MassMono: "144.113687"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0168
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00102
name: L-methionine amide
def: "A protein modification that effectively converts an L-methionine residue to L-methionine amide." [PubMed:4375977, RESID:AA0093]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-4-(methylsulfanyl)butanamide" EXACT RESID-systematic []
synonym: "2-amino-4-(methylthio)butanamide" EXACT RESID-alternate []
synonym: "amidated L-methionine" EXACT PSI-MOD-alternate []
synonym: "L-methionine amide" EXACT RESID-name []
synonym: "methioninamide" EXACT RESID-alternate []
synonym: "MetN" EXACT PSI-MOD-label []
synonym: "MOD_RES Methionine amide" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1 S 0"
xref: DiffMono: "-0.984016"
xref: Formula: "C 5 H 11 N 2 O 1 S 1"
xref: MassAvg: "147.22"
xref: MassMono: "147.059209"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0164
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:00103
name: L-phenylalanine amide
def: "A protein modification that effectively converts an L-phenylalanine residue to L-phenylalanine amide." [PubMed:2905621, PubMed:8868490, RESID:AA0094]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-phenylpropanamide" EXACT RESID-systematic []
synonym: "amidated L-phenylalanine" EXACT PSI-MOD-alternate []
synonym: "L-phenylalanine amide" EXACT RESID-name []
synonym: "MOD_RES Phenylalanine amide" EXACT UniProt-feature []
synonym: "PheN" EXACT PSI-MOD-label []
synonym: "phenylalaninamide" EXACT RESID-alternate []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 9 H 11 N 2 O 1"
xref: MassAvg: "163.20"
xref: MassMono: "163.087138"
xref: Origin: "F"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0248
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00914 ! modified L-phenylalanine residue

[Term]
id: MOD:00104
name: L-proline amide
def: "A protein modification that effectively converts an L-proline residue to L-proline amide." [PubMed:4982117, PubMed:5760861, RESID:AA0095]
subset: PSI-MOD-slim
synonym: "(2S)-pyrrolidine-2-carboxamide" EXACT RESID-systematic []
synonym: "amidated L-proline" EXACT PSI-MOD-alternate []
synonym: "L-proline amide" EXACT RESID-name []
synonym: "MOD_RES Proline amide" EXACT UniProt-feature []
synonym: "prolinamide" EXACT RESID-alternate []
synonym: "ProN" EXACT PSI-MOD-label []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 5 H 9 N 2 O 1"
xref: MassAvg: "113.14"
xref: MassMono: "113.071488"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0257
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:00105
name: L-serine amide
def: "A protein modification that effectively converts an L-serine residue to L-serine amide." [PubMed:743209, RESID:AA0096]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-hydroxypropanamide" EXACT RESID-systematic []
synonym: "amidated L-serine" EXACT PSI-MOD-alternate []
synonym: "L-serine amide" EXACT RESID-name []
synonym: "MOD_RES Serine amide" EXACT UniProt-feature []
synonym: "serinamide" EXACT RESID-alternate []
synonym: "SerN" EXACT PSI-MOD-label []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 3 H 7 N 2 O 2"
xref: MassAvg: "103.10"
xref: MassMono: "103.050752"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0275
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00106
name: L-threonine amide
def: "A protein modification that effectively converts an L-threonine residue to L-threonine amide." [PubMed:1390774, RESID:AA0097]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-hydroxybutanamide" EXACT RESID-systematic []
synonym: "amidated L-threonine" EXACT PSI-MOD-alternate []
synonym: "L-threonine amide" EXACT RESID-name []
synonym: "MOD_RES Threonine amide" EXACT UniProt-feature []
synonym: "threoninamide" EXACT RESID-alternate []
synonym: "ThrN" EXACT PSI-MOD-label []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 4 H 9 N 2 O 2"
xref: MassAvg: "117.13"
xref: MassMono: "117.066403"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0293
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:00107
name: L-tryptophan amide
def: "A protein modification that effectively converts an L-tryptophan residue to L-tryptophan amide." [PubMed:3947348, RESID:AA0098]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(1H-indol-3-yl)propanamide" EXACT RESID-systematic []
synonym: "amidated L-tryptophan" EXACT PSI-MOD-alternate []
synonym: "L-tryptophan amide" EXACT RESID-name []
synonym: "MOD_RES Tryptophan amide" EXACT UniProt-feature []
synonym: "TrpN" EXACT PSI-MOD-label []
synonym: "tryptophanamide" EXACT RESID-alternate []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 11 H 12 N 3 O 1"
xref: MassAvg: "202.24"
xref: MassMono: "202.098037"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0296
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:00108
name: L-tyrosine amide
def: "A protein modification that effectively converts an L-tyrosine residue to L-tyrosine amide." [PubMed:1377792, PubMed:3562898, PubMed:6509012, RESID:AA0099]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(4-hydoxyphenyl)propanamide" EXACT RESID-systematic []
synonym: "amidated L-tyrosine" EXACT PSI-MOD-alternate []
synonym: "L-tyrosine amide" EXACT RESID-name []
synonym: "MOD_RES Tyrosine amide" EXACT UniProt-feature []
synonym: "TyrN" EXACT PSI-MOD-label []
synonym: "tyrosinamide" EXACT RESID-alternate []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 9 H 11 N 2 O 2"
xref: MassAvg: "179.20"
xref: MassMono: "179.082053"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0302
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00109
name: L-valine amide
def: "A protein modification that effectively converts an L-valine residue to L-valine amide." [PubMed:2578459, PubMed:5465996, RESID:AA0100]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-methylbutanamide" EXACT RESID-systematic []
synonym: "L-valine amide" EXACT RESID-name []
synonym: "MOD_RES Valine amide" EXACT UniProt-feature []
synonym: "valinamide" EXACT RESID-alternate []
synonym: "ValN" EXACT PSI-MOD-label []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 5 H 11 N 2 O 1"
xref: MassAvg: "115.16"
xref: MassMono: "115.087138"
xref: Origin: "V"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0303
is_a: MOD:00883 ! C1-amidated residue
is_a: MOD:00920 ! modified L-valine residue

[Term]
id: MOD:00110
name: L-cysteine methyl disulfide
def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl disulfide." [OMSSA:179, PubMed:10555576, PubMed:163643, PubMed:2056535, PubMed:6381494, RESID:AA0101, Unimod:39#C]
comment: Produced artifactually by reaction of cysteine residues with methyl methanethiosulfonate (MMTS) [JSG], but also naturally in bacteria [PMT].
synonym: "(2R)-2-amino-3-(methyldisulfanediyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(methyldisulfanediyl)propanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-(methyldithio)propanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-methyldisulfanylpropanoic acid" EXACT RESID-alternate []
synonym: "2-azanyl-3-(methyldisulfanediyl)-propanoic acid" EXACT RESID-alternate []
synonym: "Beta-methylthiolation" RELATED Unimod-description []
synonym: "L-3-(methyldithio)alanine" EXACT RESID-alternate []
synonym: "L-cysteine methyl disulfide" EXACT RESID-name []
synonym: "methyl methanethiolsulfonate derivatized cysteine" EXACT PSI-MOD-alternate []
synonym: "methyl methanethiosulfonate derivatized cysteine" EXACT PSI-MOD-alternate []
synonym: "Methylthio" RELATED PSI-MS-label []
synonym: "Methylthio" RELATED Unimod-interim []
synonym: "mmts" EXACT OMSSA-label []
synonym: "MOD_RES Cysteine methyl disulfide" EXACT UniProt-feature []
synonym: "S-methylthio-L-cysteine" EXACT RESID-alternate []
synonym: "S-methylthiocysteine" EXACT RESID-alternate []
xref: DiffAvg: "46.09"
xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1"
xref: DiffMono: "45.987721"
xref: Formula: "C 4 H 7 N 1 O 1 S 2"
xref: MassAvg: "149.23"
xref: MassMono: "148.996906"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:39"
xref: uniprot.ptm:PTM-0104
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01153 ! methylthiolated residue
is_a: MOD:01862 ! disulfide conjugated residue

[Term]
id: MOD:00111
name: S-farnesyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine." [DeltaMass:293, OMSSA:42, PubMed:1409665, PubMed:15609361, PubMed:1872463, PubMed:2684976, RESID:AA0102, Unimod:44#C]
comment: From DeltaMass: (name misspelled "S-farnesyl cystenyl")
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-([(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(3,7,11-trimethyl-2,6,10-dodecatrienylthio)propanoic acid" EXACT RESID-alternate []
synonym: "Farnesyl" RELATED PSI-MS-label []
synonym: "Farnesylation" RELATED Unimod-description []
synonym: "farnesylationc" EXACT OMSSA-label []
synonym: "LIPID S-farnesyl cysteine" EXACT UniProt-feature []
synonym: "S-farnesyl Cystenyl" EXACT DeltaMass-label []
synonym: "S-farnesyl-L-cysteine" EXACT RESID-name []
synonym: "SFarnCys" EXACT PSI-MOD-label []
xref: DiffAvg: "204.36"
xref: DiffFormula: "C 15 H 24 N 0 O 0 S 0"
xref: DiffMono: "204.187801"
xref: Formula: "C 18 H 29 N 1 O 1 S 1"
xref: MassAvg: "307.50"
xref: MassMono: "307.196986"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:44"
xref: uniprot.ptm:PTM-0277
is_a: MOD:00437 ! farnesylated residue
is_a: MOD:01110 ! isoprenylated cysteine

[Term]
id: MOD:00112
name: S-12-hydroxyfarnesyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine." [PubMed:17790543, RESID:AA0103, Unimod:376]
synonym: "(2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(12-hydroxy-3,7,11-trimethyl-3,6,10-dodecatrienylthio)propanoic acid" EXACT RESID-alternate []
synonym: "Hydroxyfarnesyl" RELATED PSI-MS-label []
synonym: "hydroxyfarnesyl" RELATED Unimod-description []
synonym: "LIPID S-12-hydroxyfarnesyl cysteine" EXACT UniProt-feature []
synonym: "S-12-hydroxyfarnesyl-L-cysteine" EXACT RESID-name []
synonym: "S12HyFarnCys" EXACT PSI-MOD-label []
xref: DiffAvg: "220.36"
xref: DiffFormula: "C 15 H 24 N 0 O 1 S 0"
xref: DiffMono: "220.182715"
xref: Formula: "C 18 H 29 N 1 O 2 S 1"
xref: MassAvg: "323.50"
xref: MassMono: "323.191900"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:376"
xref: uniprot.ptm:PTM-0269
is_a: MOD:01110 ! isoprenylated cysteine

[Term]
id: MOD:00113
name: S-geranylgeranyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine." [DeltaMass:0, OMSSA:49, PubMed:1483450, PubMed:15609361, RESID:AA0104, Unimod:48#C]
comment: DeltaMass calculates the mass with two double bonds rather than four
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenylthio)propanoic acid" EXACT RESID-alternate []
synonym: "Geranyl-geranyl" RELATED Unimod-description []
synonym: "GeranylGeranyl" RELATED PSI-MS-label []
synonym: "geranylgeranylc" EXACT OMSSA-label []
synonym: "LIPID S-geranylgeranyl cysteine" EXACT UniProt-feature []
synonym: "S-geranylgeranyl" EXACT DeltaMass-label []
synonym: "S-geranylgeranyl-L-cysteine" EXACT RESID-name []
synonym: "SGergerCys" EXACT PSI-MOD-label []
xref: DiffAvg: "272.48"
xref: DiffFormula: "C 20 H 32 N 0 O 0 S 0"
xref: DiffMono: "272.250401"
xref: Formula: "C 23 H 37 N 1 O 1 S 1"
xref: MassAvg: "375.62"
xref: MassMono: "375.259586"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:48"
xref: uniprot.ptm:PTM-0278
is_a: MOD:00441 ! geranylgeranylated residue
is_a: MOD:01110 ! isoprenylated cysteine

[Term]
id: MOD:00114
name: L-cysteine methyl ester
def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl ester." [PubMed:11875433, PubMed:1872463, RESID:AA0105, Unimod:34#C-term]
comment: Secondary to RESID:AA0102; secondary to RESID:AA0103; secondary to RESID:AA0104.
subset: PSI-MOD-slim
synonym: "2-amino-3-mercaptopropanoic methyl ester" EXACT RESID-alternate []
synonym: "2-amino-3-sulfanylpropanoic methyl ester" EXACT RESID-alternate []
synonym: "L-cysteine methyl ester" EXACT RESID-name []
synonym: "mecysteine" EXACT RESID-alternate []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic []
synonym: "methyl esterified L-cysteine" EXACT PSI-MOD-alternate []
synonym: "methyl L-cysteinate" EXACT RESID-alternate []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES Cysteine methyl ester" EXACT UniProt-feature []
synonym: "OMeCys" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 4 H 8 N 1 O 2 S 1"
xref: MassAvg: "134.17"
xref: MassMono: "134.027574"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:34"
xref: uniprot.ptm:PTM-0105
is_a: MOD:01682 ! monomethylated L-cysteine
is_a: MOD:01689 ! alpha-carboxyl methylated residue

[Term]
id: MOD:00115
name: S-palmitoyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine." [DeltaMass:303, PubMed:1872406, PubMed:3166978, PubMed:8180229, PubMed:8824274, RESID:AA0106, Unimod:47#C]
comment: From DeltaMass: (name misspelled "S-palmityl Cystenyl" and formula incorrect, N and O reversed) Formula: C19H35O1N2S1 Monoisotopic Mass Change: 341.239 Average Mass Change: 341.556
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-(hexadecanoylsulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(hexadecanoylthio)propanoic acid" EXACT RESID-alternate []
synonym: "ACT_SITE S-palmitoyl cysteine intermediate" EXACT UniProt-feature []
synonym: "cysteine hexadecanoate thioester" EXACT RESID-alternate []
synonym: "cysteine palmitate thioester" EXACT RESID-alternate []
synonym: "LIPID S-palmitoyl cysteine" EXACT UniProt-feature []
synonym: "Palmitoyl" RELATED PSI-MS-label []
synonym: "Palmitoylation" RELATED Unimod-description []
synonym: "S-palmitoyl-L-cysteine" EXACT RESID-name []
synonym: "S-palmitoylated L-cysteine" EXACT PSI-MOD-alternate []
synonym: "S-hexadecanoylated L-cysteine" EXACT PSI-MOD-alternate []
synonym: "S-palmityl Cystenyl" EXACT DeltaMass-label []
synonym: "SPamCys" EXACT PSI-MOD-label []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0"
xref: DiffMono: "238.229666"
xref: Formula: "C 19 H 35 N 1 O 2 S 1"
xref: MassAvg: "341.55"
xref: MassMono: "341.238850"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:47"
xref: uniprot.ptm:PTM-0281
is_a: MOD:00653 ! S-palmitoylated residue
is_a: MOD:01684 ! palmitoylated-L-cysteine

[Term]
id: MOD:00116
name: S-diacylglycerol-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-diacylglycerol-L-cysteine." [PubMed:10896212, PubMed:4575979, PubMed:9056182, RESID:AA0107, Unimod:377#C]
comment: Incidental to RESID:AA0060.
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-[(2S)-2-((9Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid" EXACT RESID-alternate []
synonym: "Diacylglycerol" RELATED PSI-MS-label []
synonym: "diacylglycerol" RELATED Unimod-description []
synonym: "LIPID S-diacylglycerol cysteine" EXACT UniProt-feature []
synonym: "S-(1-2'-oleoyl-3'-palmitoyl-glycerol)cysteine" EXACT RESID-alternate []
synonym: "S-(2',3'-diacylglycerol)-L-cysteine" EXACT PSI-MOD-alternate []
synonym: "S-diacylglycerol-L-cysteine" EXACT RESID-name []
synonym: "SAcyl2GlyceroCys" EXACT PSI-MOD-label []
xref: uniprot.ptm:PTM-0274
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00117
name: S-(L-isoglutamyl)-L-cysteine
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia." [ChEBI:22021, DeltaMass:0, PubMed:6838833, RESID:AA0108]
comment: Cross-link 2; DeltaMass calculates the mass difference from glutamic acid rather than glutamine.
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "(S,R)-2-amino-4-[S-(2-amino-2-carboxyethyl)thiocarboxy]butanoic acid" EXACT RESID-alternate []
synonym: "2-amino-5-(2-amino-2-carboxyethyl)thio-5-oxopentanoic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Isoglutamyl cysteine thioester (Cys-Gln)" EXACT UniProt-feature []
synonym: "gamma-(S-cysteinyl)glutamic acid" EXACT RESID-alternate []
synonym: "S-(L-isoglutamyl)-L-cysteine" EXACT RESID-name []
synonym: "S-gamma-glutamyl (crosslinked to cysteine)" EXACT DeltaMass-label []
synonym: "XLNK-SCys-5Glu(Gln)" EXACT PSI-MOD-label []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 8 H 10 N 2 O 3 S 1"
xref: MassAvg: "214.24"
xref: MassMono: "214.041213"
xref: Origin: "C, Q"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0156
is_a: MOD:00395 ! thioester crosslinked residues
is_a: MOD:02046 ! crosslinked L-glutamine residue
is_a: MOD:00946 ! crosslinked residues with loss of ammonia

[Term]
id: MOD:00118
name: 2'-(S-L-cysteinyl)-L-histidine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-histidine residue by a thioether bond to form 2'-(S-L-cysteinyl)-L-histidine." [DeltaMass:0, PubMed:6210696, RESID:AA0109]
comment: Cross-link 2.
synonym: "(2R)-2-amino-3-[(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)sulfanyl]propanoic acid" EXACT RESID-systematic []
synonym: "(2S)-2-amino-3-[2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-1H-imidazol-4-yl]propanoic acid" EXACT RESID-alternate []
synonym: "2'-(L-cystein-S-yl)-L-histidine" EXACT RESID-name []
synonym: "CROSSLNK 2'-(S-cysteinyl)-histidine (Cys-His)" EXACT UniProt-feature []
synonym: "S-(2'-histidyl)cysteine" EXACT RESID-alternate []
synonym: "S-(2-histidyl)- (crosslinked to cysteine)" EXACT DeltaMass-label []
synonym: "XLNK-SCys-2'His" EXACT PSI-MOD-label []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 9 H 10 N 4 O 2 S 1"
xref: MassAvg: "238.26"
xref: MassMono: "238.052447"
xref: Origin: "C, H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0005
is_a: MOD:00687 ! thioether crosslinked residues
is_a: MOD:02048 ! crosslinked L-histidine residue

[Term]
id: MOD:00119
name: L-lanthionine (Cys-Ser)
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine." [ChEBI:21347, DeltaMass:7, RESID:AA0110#CSX]
comment: Cross-link 2. The natural occurrence of this modification is rare. For the more common modification see MOD:00120 meso-lanthionine [JSG].
synonym: "(2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid)" EXACT RESID-systematic []
synonym: "(R)-S-(2-amino-2-carboxyethyl)-L-cysteine" EXACT RESID-alternate []
synonym: "(R,R)-2,6-diamino-4-thiaheptanedioic acid" EXACT RESID-alternate []
synonym: "(R,R)-3,3'-thiobis-(2-aminopropanoic acid)" EXACT RESID-alternate []
synonym: "(R,R)-bis(2-amino-2-carboxyethyl)sulfide" EXACT RESID-alternate []
synonym: "2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid" EXACT RESID-alternate []
synonym: "3,3'-thiobis-L-alanine" EXACT RESID-alternate []
synonym: "L-lanthionine" EXACT RESID-name []
synonym: "XLNK-SCys-(L)3Dha" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 6 H 8 N 2 O 2 S 1"
xref: MassAvg: "172.20"
xref: MassMono: "172.030649"
xref: Origin: "C, S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01839 ! L-lanthionine

[Term]
id: MOD:00120
name: meso-lanthionine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form meso-lanthionine." [PubMed:15023056, PubMed:3769923, RESID:AA0111]
comment: Cross-link 2.
synonym: "(2R,2'S)-3,3'-sulfanediylbis(2-aminopropanoic acid)" EXACT RESID-systematic []
synonym: "(2R,2'S)-3,3'-thiobis-(2-aminopropanoic acid)" EXACT RESID-alternate []
synonym: "(2R,6S)-2,6-diamino-4-thiaheptanedioic acid" EXACT RESID-alternate []
synonym: "(2R,6S)-meso-lanthionine" EXACT RESID-alternate []
synonym: "(2S)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]sulfanyl]propanoic acid" EXACT RESID-alternate []
synonym: "(2S,6R)-meso-lanthionine" RELATED RESID-misnomer []
synonym: "(R)-S-(2-amino-2-carboxyethyl)-D-cysteine" EXACT RESID-alternate []
synonym: "(R,S)-bis(2-amino-2-carboxyethyl)sulfide" EXACT RESID-alternate []
synonym: "3,3'-thiobis-meso-alanine" EXACT RESID-alternate []
synonym: "CROSSLNK Lanthionine (Cys-Ser)" EXACT UniProt-feature []
synonym: "CROSSLNK Lanthionine (Ser-Cys)" EXACT UniProt-feature []
synonym: "cysteine-3-D-alanine thioether" EXACT RESID-alternate []
synonym: "meso-lanthionine" EXACT RESID-name []
synonym: "XLNK-SCys-(D)3Dha" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 6 H 8 N 2 O 2 S 1"
xref: MassAvg: "172.20"
xref: MassMono: "172.030649"
xref: Origin: "C, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0164
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01841 ! lanthionine

[Term]
id: MOD:00121
name: (2S,3S,2'R)-3-methyllanthionine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine." [PubMed:3769923, RESID:AA0112]
comment: Cross-link 2.
synonym: "(2S,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "(2S,3S,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT RESID-alternate []
synonym: "(2S,3S,2'R)-3-methyllanthionine" EXACT RESID-name []
synonym: "(2S,3S,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid" EXACT RESID-alternate []
synonym: "(2S,3S,6R)-3-methyllanthionine" EXACT RESID-alternate []
synonym: "(2S-[2R*,3R*(S*)])-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT RESID-alternate []
synonym: "3-methyl-D,L-lanthionine" EXACT RESID-alternate []
synonym: "CROSSLNK Beta-methyllanthionine (Cys-Thr)" EXACT UniProt-feature []
synonym: "CROSSLNK Beta-methyllanthionine (Thr-Cys)" EXACT UniProt-feature []
synonym: "cysteine-3-D-butyrine thioether" EXACT RESID-alternate []
synonym: "XLNK-SCys-3Dhb" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 7 H 10 N 2 O 2 S 1"
xref: MassAvg: "186.23"
xref: MassMono: "186.046299"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0067
is_a: MOD:01981 ! 3-methyllanthionine

[Term]
id: MOD:00122
name: 3'-(S-L-cysteinyl)-L-tyrosine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-tyrosine." [DeltaMass:0, PubMed:15917234, PubMed:2002850, RESID:AA0113]
comment: Cross-link 2.
synonym: "(2S)-2-amino-3-(3-[(2R)2-amino-2-carboxyethylsulfanyl]-4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-[3-(2-amino-2-carboxyethylthio)-4-hydroxyphenyl]propanoic acid" EXACT RESID-alternate []
synonym: "3'-(cystein-S-yl)tyrosine" EXACT RESID-alternate []
synonym: "3'-(L-cystein-S-yl)-L-tyrosine" EXACT RESID-name []
synonym: "CROSSLNK 3'-(S-cysteinyl)-tyrosine (Cys-Tyr)" EXACT UniProt-feature []
synonym: "CROSSLNK 3'-(S-cysteinyl)-tyrosine (Tyr-Cys)" EXACT UniProt-feature []
synonym: "S-(3-Tyr) (Crosslinked to Cysteine)" EXACT DeltaMass-label []
synonym: "S-(tyros-3'-yl)cysteine" EXACT RESID-alternate []
synonym: "XLNK-SCys-3'Tyr" EXACT PSI-MOD-label []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 12 H 12 N 2 O 3 S 1"
xref: MassAvg: "264.30"
xref: MassMono: "264.056863"
xref: Origin: "C, Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0019
is_a: MOD:00687 ! thioether crosslinked residues
is_a: MOD:02058 ! crosslinked L-tyrosine residue

[Term]
id: MOD:00123
name: N6-carboxy-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-carboxy-L-lysine." [PubMed:11369851, PubMed:4436319, PubMed:637859, PubMed:7754395, RESID:AA0114, Unimod:299#K]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-(carboxyamino)hexanoic acid" EXACT RESID-systematic []
synonym: "2-amino-6-carbamic hexanoic acid" EXACT RESID-alternate []
synonym: "Carboxy" RELATED Unimod-interim []
synonym: "Carboxylation" RELATED Unimod-description []
synonym: "lysine NZ-carboxylic acid" EXACT RESID-alternate []
synonym: "MOD_RES N6-carboxylysine" EXACT UniProt-feature []
synonym: "N6-carbamyllysine" RELATED RESID-misnomer []
synonym: "N6-carboxy-L-lysine" EXACT RESID-name []
synonym: "N6-carboxylysine" EXACT RESID-alternate []
synonym: "N6CbxLys" EXACT PSI-MOD-label []
xref: DiffAvg: "44.01"
xref: DiffFormula: "C 1 H 0 N 0 O 2"
xref: DiffMono: "43.989829"
xref: Formula: "C 7 H 12 N 2 O 3"
xref: MassAvg: "172.18"
xref: MassMono: "172.084792"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:299"
xref: uniprot.ptm:PTM-0191
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01152 ! carboxylated residue

[Term]
id: MOD:00124
name: N6-1-carboxyethyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-1-carboxyethyl-L-lysine." [PubMed:3123486, PubMed:8253186, PubMed:8421682, RESID:AA0115, Unimod:378#K]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-([(1S)-1-carboxyethyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "Carboxyethyl" RELATED PSI-MS-label []
synonym: "carboxyethyl" RELATED Unimod-description []
synonym: "MOD_RES N6-1-carboxyethyl lysine" EXACT UniProt-feature []
synonym: "N6-(1-carboxyethyl)-L-lysine" EXACT RESID-name []
synonym: "N6-(1-carboxyethyl)lysine" EXACT RESID-alternate []
synonym: "N6CbzEtLys" EXACT PSI-MOD-label []
synonym: "NZ-(1-carboxyethyl)lysine" EXACT RESID-alternate []
xref: DiffAvg: "72.06"
xref: DiffFormula: "C 3 H 4 N 0 O 2"
xref: DiffMono: "72.021129"
xref: Formula: "C 9 H 16 N 2 O 3"
xref: MassAvg: "200.24"
xref: MassMono: "200.116092"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:378"
xref: uniprot.ptm:PTM-0189
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00125
name: hypusine
def: "A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [DeltaMass:0, PubMed:6806267, PubMed:8108861, RESID:AA0116, Unimod:379#K]
comment: This modification occurs uniquely in translation initiation factor eIF-5A [JSG].
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-([(2R)-4-amino-2-hydroxybutyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "(2S,9R)-2,11-diazanyl-9-hydroxy-7-azaundecanoic acid" EXACT RESID-alternate []
synonym: "(2S,9R)-hypusine" EXACT RESID-alternate []
synonym: "2-azanyl-6-[(4-azanyl-2-hydroxybutyl)azanyl]hexanoic acid" EXACT RESID-alternate []
synonym: "Hypu" EXACT PSI-MOD-label []
synonym: "Hypusine" RELATED PSI-MS-label []
synonym: "hypusine" RELATED Unimod-description []
synonym: "L-hypusine" EXACT RESID-name []
synonym: "MOD_RES Hypusine" EXACT UniProt-feature []
synonym: "N-(4-NH2-2-OH-butyl)- (of Lysine)" EXACT DeltaMass-label []
synonym: "N6-(4-amino-2-hydroxybutyl)-L-lysine" EXACT RESID-alternate []
xref: DiffAvg: "87.12"
xref: DiffFormula: "C 4 H 9 N 1 O 1"
xref: DiffMono: "87.068414"
xref: Formula: "C 10 H 21 N 3 O 2"
xref: MassAvg: "215.30"
xref: MassMono: "215.163377"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:379"
xref: uniprot.ptm:PTM-0150
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01884 ! 4-aminobutylated residue
relationship: derives_from MOD:01880 ! L-deoxyhypusine

[Term]
id: MOD:00126
name: N6-biotinyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine." [DeltaMass:305, PubMed:16109483, PubMed:3178228, PubMed:7948875, PubMed:8747466, RESID:AA0117, Unimod:3#K]
comment: From DeltaMass: Average Mass: 354 Formula:C 16 H 26 O 4 N 3 S 1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:354.172 Average Mass Change:354.471 References:PE Sciex.
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-(5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoylamino)hexanoic acid" EXACT RESID-systematic []
synonym: "(3aS-(3aalpha,4beta,6aalpha))-N6-(5-(hexahydro-2-oxo-1H-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)-L-lysine" EXACT RESID-alternate []
synonym: "biocytin" EXACT RESID-alternate []
synonym: "Biotin" RELATED PSI-MS-label []
synonym: "biotinyl lysyl" EXACT DeltaMass-label []
synonym: "Biotinylation" RELATED Unimod-description []
synonym: "epsilon-N-biotinyllysine" EXACT RESID-alternate []
synonym: "MOD_RES N6-biotinyllysine" EXACT UniProt-feature []
synonym: "N6-[5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-L-lysine" EXACT RESID-alternate []
synonym: "N6-biotinyl-L-lysine" EXACT RESID-name []
synonym: "N6-biotinyllysine" EXACT RESID-alternate []
synonym: "N6BtnLys" EXACT PSI-MOD-label []
xref: DiffAvg: "226.29"
xref: DiffFormula: "C 10 H 14 N 2 O 2 S 1"
xref: DiffMono: "226.077599"
xref: Formula: "C 16 H 26 N 4 O 3 S 1"
xref: MassAvg: "354.47"
xref: MassMono: "354.172562"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:3"
xref: uniprot.ptm:PTM-0382
is_a: MOD:01875 ! N6-acylated L-lysine
is_a: MOD:01885 ! biotinylated residue

[Term]
id: MOD:00127
name: N6-lipoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine." [DeltaMass:0, OMSSA:67, PubMed:3421911, PubMed:3522581, PubMed:7719855, RESID:AA0118, Unimod:42#K]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-(5-[(3R)-1,2-dithiolan-3-yl]pentanamido)hexanoic acid" EXACT RESID-alternate []
synonym: "(2S)-2-amino-6-[(5-[(3R)-1,2-dithiolan-3-yl]pentanoyl)amino]hexanoic acid" EXACT RESID-systematic []
synonym: "(2S,6'R)-2-amino-6-(6,8-dithiooctanamido)hexanoic acid" EXACT RESID-alternate []
synonym: "2-amino-6-(5-[1,2-dithiolan-3-yl]-1-oxopentyl)aminohexanoic acid" EXACT RESID-alternate []
synonym: "Lipoyl" RELATED PSI-MS-label []
synonym: "Lipoyl" RELATED Unimod-description []
synonym: "lipoylk" EXACT OMSSA-label []
synonym: "MOD_RES N6-lipoyllysine" EXACT UniProt-feature []
synonym: "N-Lipoyl- (on Lysine)" EXACT DeltaMass-label []
synonym: "N6-6,8-dithiooctanoyllysine" EXACT RESID-alternate []
synonym: "N6-lipoyl-L-lysine" EXACT RESID-name []
synonym: "N6-lipoyllysine" EXACT RESID-alternate []
synonym: "N6LipLys" EXACT PSI-MOD-label []
xref: DiffAvg: "188.30"
xref: DiffFormula: "C 8 H 12 N 0 O 1 S 2"
xref: DiffMono: "188.032957"
xref: Formula: "C 14 H 24 N 2 O 2 S 2"
xref: MassAvg: "316.48"
xref: MassMono: "316.127920"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:42"
xref: uniprot.ptm:PTM-0383
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:00128
name: N6-pyridoxal phosphate-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine." [DeltaMass:0, PubMed:1544460, RESID:AA0119, Unimod:46#K]
comment: From DeltaMass: Average Mass: 231
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-[([3-hydroxy-2-methyl-5-phosphonooxymethylpyridin-4-yl]methylidene)amino]hexanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES N6-(pyridoxal phosphate)lysine" EXACT UniProt-feature []
synonym: "N6-pyridoxal phosphate-L-lysine" EXACT RESID-name []
synonym: "N6PydoxLys" EXACT PSI-MOD-label []
synonym: "Pyridoxal phosphate" RELATED Unimod-description []
synonym: "Pyridoxal phosphate (Schiff Base formed to lysine)" EXACT DeltaMass-label []
synonym: "PyridoxalPhosphate" RELATED PSI-MS-label []
xref: DiffAvg: "229.13"
xref: DiffFormula: "C 8 H 8 N 1 O 5 P 1"
xref: DiffMono: "229.014009"
xref: Formula: "C 14 H 20 N 3 O 6 P 1"
xref: MassAvg: "357.30"
xref: MassMono: "357.108972"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:46"
xref: uniprot.ptm:PTM-0387
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00129
name: N6-retinylidene-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine, the adduct of retinal." [PubMed:6794028, PubMed:6870827, RESID:AA0120, Unimod:380#K]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES N6-(retinylidene)lysine" EXACT UniProt-feature []
synonym: "N6-retinal-L-lysine" EXACT RESID-alternate []
synonym: "N6-retinyl-lysine" EXACT RESID-alternate []
synonym: "N6-retinylidene-L-lysine" EXACT RESID-name []
synonym: "N6RetalLys" EXACT PSI-MOD-label []
synonym: "retinal" RELATED Unimod-description []
synonym: "Retinylidene" RELATED PSI-MS-label []
xref: DiffAvg: "266.43"
xref: DiffFormula: "C 20 H 26 N 0 O 0"
xref: DiffMono: "266.203451"
xref: Formula: "C 26 H 38 N 2 O 1"
xref: MassAvg: "394.60"
xref: MassMono: "394.298414"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:380"
xref: uniprot.ptm:PTM-0388
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00130
name: L-allysine
def: "A protein modification that effectively converts an L-lysine residue to L-allysine." [ChEBI:17917, DeltaMass:0, PubMed:11120890, PubMed:11332453, PubMed:358196, PubMed:5337886, PubMed:5529814, RESID:AA0121, Unimod:352#K]
comment: From DeltaMass: Average Mass: -1
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-oxohexanoic acid" EXACT RESID-systematic []
synonym: "2-amino-5-formylvaleric acid" EXACT RESID-alternate []
synonym: "2-amino-adipic acid semialdahyde" EXACT RESID-alternate []
synonym: "2-aminoadipate 6-semialdehyde" EXACT RESID-alternate []
synonym: "5-formyl-norvaline" EXACT RESID-alternate []
synonym: "6-oxonorleucine" EXACT RESID-alternate []
synonym: "AASA" EXACT RESID-alternate []
synonym: "Allysine (from Lysine)" EXACT DeltaMass-label []
synonym: "alpha-amino-adipic acid delta-semialdahyde" EXACT RESID-alternate []
synonym: "L-allysine" EXACT RESID-name []
synonym: "Lys->Allysine" RELATED PSI-MS-label []
synonym: "Lysal" EXACT PSI-MOD-label []
synonym: "Lysine oxidation to aminoadipic semialdehyde" RELATED Unimod-description []
synonym: "MOD_RES Allysine" EXACT UniProt-feature []
synonym: "Oxidation of lysine (to aminoadipic semialdehyde)" EXACT DeltaMass-label []
xref: DiffAvg: "-1.03"
xref: DiffFormula: "C 0 H -3 N -1 O 1"
xref: DiffMono: "-1.031634"
xref: Formula: "C 6 H 9 N 1 O 2"
xref: MassAvg: "127.14"
xref: MassMono: "127.063329"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:352"
xref: uniprot.ptm:PTM-0059
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00131
name: L-2-aminoadipic acid
def: "A protein modification that effectively converts an L-lysine residue to L-2-aminoadipic acid." [DeltaMass:353, PubMed:336041, PubMed:358196, PubMed:7419498, RESID:AA0122, Unimod:381#K]
comment: From DeltaMass: References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. Notes:Expected reaction following oxidation of lysine to aminoadipic semialdehyde. Not proven experimentally but deduced by reference to the similar known reaction of oxidation of Arg to Glu via the semialdehyde. [This has been observed as a natural modification, see RESID:AA0122. JSG]
subset: PSI-MOD-slim
synonym: "(2S)-2-aminohexanedioic acid" EXACT RESID-systematic []
synonym: "2-amino-1,4-butanedicarboxylic acid" EXACT RESID-alternate []
synonym: "alpha-amino adipic acid" RELATED Unimod-description []
synonym: "L-2-aminoadipic acid" EXACT RESID-name []
synonym: "L-alpha-aminoadipic acid" EXACT RESID-alternate []
synonym: "Lys->AminoadipicAcid" RELATED PSI-MS-label []
synonym: "Lysoic" EXACT PSI-MOD-label []
synonym: "Oxidation of lysine (to aminoadipic acid)" EXACT DeltaMass-label []
xref: DiffAvg: "14.97"
xref: DiffFormula: "C 0 H -3 N -1 O 2"
xref: DiffMono: "14.963280"
xref: Formula: "C 6 H 9 N 1 O 3"
xref: MassAvg: "143.14"
xref: MassMono: "143.058243"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:381"
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00132
name: L-lysinoalanine (Lys-Ser)
def: "A protein modification that effectively crosslinks an L-serine residue and an L-lysine residue to release water and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid." [DeltaMass:0, PubMed:2544544, RESID:AA0123#KSX]
comment: Cross-link 2. This entry is for the crosslink of peptidyl serine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34.
synonym: "(2R,9S)-lysinoalanine" EXACT RESID-alternate []
synonym: "(2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "alaninolysine" EXACT RESID-alternate []
synonym: "CROSSLNK Lysinoalanine (Ser-Lys)" EXACT UniProt-feature []
synonym: "L-lysinoalanine" EXACT RESID-name []
synonym: "LAL" EXACT RESID-alternate []
synonym: "Lysinoalanine (from Cysteine)" EXACT DeltaMass-label []
synonym: "N-epsilon-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate []
synonym: "N6-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate []
synonym: "XLNK-N6Lys-3Dha(Ser)" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 9 H 15 N 3 O 2"
xref: MassAvg: "197.24"
xref: MassMono: "197.116427"
xref: Origin: "K, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0172
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01853 ! L-lysinoalanine

[Term]
id: MOD:00133
name: N6-(L-isoglutamyl)-L-lysine (Gln)
def: "A protein modification that effectively crosslinks an L-glutamine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoglutamyl)-L-lysine and the release of ammonia." [ChEBI:21863, DeltaMass:0, PubMed:2461365, PubMed:5637041, PubMed:5656070, PubMed:8598899, RESID:AA0124#GLN]
comment: Cross-link 2.
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid" EXACT RESID-alternate []
synonym: "5-glutamyl N6-lysine" EXACT RESID-alternate []
synonym: "CROSSLNK Isoglutamyl lysine isopeptide (Lys-Gln)" EXACT UniProt-feature []
synonym: "N alpha -(gamma-Glutamyl)-lysine" EXACT DeltaMass-label []
synonym: "N(epsilon)-(gamma-glutamyl)lysine" EXACT RESID-alternate []
synonym: "N6-(L-isoglutamyl)-L-lysine" EXACT RESID-name []
synonym: "XLNK-N6Lys-5Glu(Gln)" EXACT PSI-MOD-label []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 11 H 17 N 3 O 3"
xref: MassAvg: "239.27"
xref: MassMono: "239.126991"
xref: Origin: "K, Q"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0158
is_a: MOD:02046 ! crosslinked L-glutamine residue
is_a: MOD:00946 ! crosslinked residues with loss of ammonia
is_a: MOD:01630 ! N6-(L-isoglutamyl)-L-lysine

[Term]
id: MOD:00134
name: N6-glycyl-L-lysine
def: "A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine." [ChEBI:21885, RESID:AA0125]
comment: Cross-link 2; this is the common crosslink structure formed by ubiquitin, SUMO, and similar proteins.
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-[(aminoacetyl)amino]hexanoic acid" EXACT RESID-systematic []
synonym: "N6-(glycyl)-L-lysine" EXACT RESID-name []
synonym: "N6-glycyllysine" EXACT RESID-alternate []
synonym: "XLNK-N6Lys-1Gly" EXACT PSI-MOD-label []
synonym: "CROSSLNK Glycyl lysine isopeptide (Gly-Lys) (interchain with K-...)" EXACT UniProt-feature []
synonym: "CROSSLNK Glycyl lysine isopeptide (Lys-Gly) (interchain with G-...)" EXACT UniProt-feature []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 8 H 14 N 3 O 2"
xref: MassAvg: "184.22"
xref: MassMono: "184.108602"
xref: Origin: "G, K"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0134
is_a: MOD:00688 ! isopeptide crosslinked residues
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:00135
name: N-(L-isoaspartyl)-glycine (Asn)
def: "A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine and the release of ammonia." [ChEBI:21479, PubMed:1826288, RESID:AA0126]
comment: Cross-link 2.
synonym: "(2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "2-amino-N4-(carboxymethyl)-butanediamic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Asn-Gly)" EXACT UniProt-feature []
synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asn)" EXACT UniProt-feature []
synonym: "isoaspartyl glycine" EXACT RESID-alternate []
synonym: "N-(L-isoaspartyl)-glycine" EXACT RESID-name []
synonym: "N-beta-aspartylglycine" EXACT RESID-alternate []
synonym: "N4-(carboxymethyl)-asparagine" EXACT RESID-alternate []
synonym: "XLNK-4Asp-NGly(Asn)" EXACT PSI-MOD-label []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 6 H 7 N 2 O 3"
xref: MassAvg: "155.13"
xref: MassMono: "155.045667"
xref: Origin: "G, N"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0489
is_a: MOD:02042 ! crosslinked L-asparagine residue
is_a: MOD:00946 ! crosslinked residues with loss of ammonia
is_a: MOD:01928 ! N-(L-isoaspartyl)-glycine

[Term]
id: MOD:00136
name: pyruvic acid (Cys)
def: "A protein modification that effectively converts an L-cysteine residue to pyruvic acid." [PubMed:10085076, PubMed:3042771, PubMed:8464063, RESID:AA0127#CYS, Unimod:382]
subset: PSI-MOD-slim
synonym: "2-oxopropanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES Pyruvic acid (Cys)" EXACT UniProt-feature []
synonym: "Pyruv(Cys)" EXACT PSI-MOD-label []
synonym: "pyruvic acid" EXACT RESID-name []
xref: DiffAvg: "-33.09"
xref: DiffFormula: "C 0 H -3 N -1 O 1 S -1"
xref: DiffMono: "-33.003705"
xref: Formula: "C 3 H 3 O 2"
xref: MassAvg: "71.06"
xref: MassMono: "71.013304"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:382"
xref: uniprot.ptm:PTM-0265
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01154 ! pyruvic acid

[Term]
id: MOD:00137
name: L-3-phenyllactic acid
def: "A protein modification that effectively converts an L-phenylalanine residue into L-3-phenyllactic acid." [PubMed:1973541, RESID:AA0128, Unimod:7#F]
comment: This modification is not the result of deamidation, instead the alpha amino group is replaced with an hydroxyl group.
synonym: "(2S)-2-hydroxy-3-phenylpropanoic acid" EXACT RESID-systematic []
synonym: "Deamidated" RELATED Unimod-interim []
synonym: "Deamidation" RELATED Unimod-description []
synonym: "L-3-phenyllactic acid" EXACT RESID-name []
synonym: "MOD_RES 3-phenyllactic acid" EXACT UniProt-feature []
xref: DiffAvg: "0.98"
xref: DiffFormula: "C 0 H -1 N -1 O 1"
xref: DiffMono: "0.984016"
xref: Formula: "C 9 H 9 O 2"
xref: MassAvg: "149.17"
xref: MassMono: "149.060255"
xref: Origin: "F"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:7"
xref: uniprot.ptm:PTM-0035
is_a: MOD:00914 ! modified L-phenylalanine residue

[Term]
id: MOD:00138
name: 2-oxobutanoic acid
def: "A protein modification that effectively converts an L-threonine residue into 2-oxobutanoic acid." [PubMed:15023056, PubMed:1680314, PubMed:2253617, PubMed:2764678, RESID:AA0129, Unimod:385#T, ChEBI:149508]
synonym: "2-ketobutyric acid" EXACT RESID-alternate []
synonym: "2-oxobutanoic acid" EXACT RESID-name []
synonym: "2-oxobutanoic acid" EXACT RESID-systematic []
synonym: "2-oxobutyric acid" EXACT RESID-alternate []
synonym: "Ammonia-loss" RELATED Unimod-interim []
synonym: "Loss of ammonia" RELATED Unimod-description []
synonym: "MOD_RES 2-oxobutanoic acid" EXACT UniProt-feature []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 4 H 5 O 2"
xref: MassAvg: "85.08"
xref: MassMono: "85.028954"
xref: Origin: "T"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:385"
xref: uniprot.ptm:PTM-0017
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:01160 ! deaminated residue

[Term]
id: MOD:00139
name: N2-succinyl-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to N2-succinyl-L-tryptophan." [PubMed:11857757, PubMed:12175151, PubMed:8471040, RESID:AA0130, Unimod:64#N-term]
synonym: "(2S)-2-(3-carboxypropanoyl)amino-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "(2S)-2-amino-(6,7-dihydro-6,7-dioxo-1H-indole)-3-propanoic acid" EXACT RESID-alternate []
synonym: "MOD_RES N2-succinyltryptophan" EXACT UniProt-feature []
synonym: "N2-succinyl-L-tryptophan" EXACT RESID-name []
synonym: "Succinic anhydride labeling reagent light form (N-term)" RELATED Unimod-description []
synonym: "Succinyl" RELATED PSI-MS-label []
xref: DiffAvg: "100.07"
xref: DiffFormula: "C 4 H 4 N 0 O 3"
xref: DiffMono: "100.016044"
xref: Formula: "C 15 H 15 N 2 O 4"
xref: MassAvg: "287.29"
xref: MassMono: "287.103182"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:64"
xref: uniprot.ptm:PTM-0181
is_a: MOD:02081 ! alpha-amino succinylated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:00140
name: S-phycocyanobilin-L-cysteine
def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycocyanobilin." [ChEBI:15617, DeltaMass:0, PubMed:16644722, PubMed:3208761, PubMed:3838747, PubMed:7918400, RESID:AA0131, Unimod:387#C]
comment: From DeltaMass: Average Mass: 587.
synonym: "(2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-ethyl-1,2,3,19,21,22,24-heptahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid" EXACT RESID-alternate []
synonym: "(2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic []
synonym: "BINDING Phycocyanobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature []
synonym: "PCB" EXACT RESID-alternate []
synonym: "phycobilin cysteine" EXACT RESID-alternate []
synonym: "Phycocyanobilin" RELATED PSI-MS-label []
synonym: "phycocyanobilin" RELATED Unimod-description []
synonym: "phycocyanobilin cysteine adduct" EXACT RESID-alternate []
synonym: "S-Phycocyanobilin (on Cysteine)" EXACT DeltaMass-label []
synonym: "S-phycocyanobilin-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "586.69"
xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0"
xref: DiffMono: "586.279135"
xref: Formula: "C 36 H 43 N 5 O 7 S 1"
xref: MassAvg: "689.83"
xref: MassMono: "689.288320"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:387"
is_a: MOD:00700 ! tetrapyrrole modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00141
name: S-phycoerythrobilin-L-cysteine
def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoerythrobilin." [ChEBI:15618, PubMed:14588022, PubMed:3208761, PubMed:3838747, PubMed:8876649, RESID:AA0132, Unimod:388#C]
synonym: "(2S,3R,16R)-18-ethenyl-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic []
synonym: "18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid" EXACT RESID-alternate []
synonym: "BINDING Phycoerythrobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature []
synonym: "PEB" EXACT RESID-alternate []
synonym: "Phycoerythrobilin" RELATED PSI-MS-label []
synonym: "phycoerythrobilin" RELATED Unimod-description []
synonym: "phycoerythrobilin cysteine adduct" EXACT RESID-alternate []
synonym: "S-phycoerythrobilin-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "588.70"
xref: DiffFormula: "C 33 H 40 N 4 O 6 S 0"
xref: DiffMono: "588.294785"
xref: Formula: "C 36 H 45 N 5 O 7 S 1"
xref: MassAvg: "691.84"
xref: MassMono: "691.303970"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:388"
is_a: MOD:00700 ! tetrapyrrole modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00142
name: S-phytochromobilin-L-cysteine
def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phytochromobilin." [ChEBI:15619, PubMed:1634523, PubMed:16593380, PubMed:3208761, PubMed:7918400, RESID:AA0133, Unimod:389#C]
synonym: "(2R,3R)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-2,7,13,17-tetramethyl-1,2,3,19,21,22,24-heptahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic []
synonym: "18-ethenyl-3-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-1,2,3,19,22,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid" EXACT RESID-alternate []
synonym: "BINDING Phytochromobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature []
synonym: "phytochrome chromophore" EXACT RESID-alternate []
synonym: "Phytochromobilin" RELATED PSI-MS-label []
synonym: "phytochromobilin" RELATED Unimod-description []
synonym: "phytochromobilin cysteine adduct" EXACT RESID-alternate []
synonym: "S-phytochromobilin-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "584.67"
xref: DiffFormula: "C 33 H 36 N 4 O 6 S 0"
xref: DiffMono: "584.263485"
xref: Formula: "C 36 H 41 N 5 O 7 S 1"
xref: MassAvg: "687.81"
xref: MassMono: "687.272670"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:389"
is_a: MOD:00700 ! tetrapyrrole modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00143
name: heme-bis-L-cysteine
def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [ChEBI:17627, PubMed:5545094, PubMed:8827449, RESID:AA0134]
comment: Cross-link 2.
subset: PSI-MOD-slim
synonym: "(7,12-bis[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate" EXACT RESID-systematic []
synonym: "2,4-bis[1-(S-cysteinyl)ethyl]protoporphyrin IX" EXACT RESID-alternate []
synonym: "BINDING Heme (covalent)" EXACT UniProt-feature []
synonym: "biscysteinyl heme" EXACT RESID-alternate []
synonym: "heme-bis-L-cysteine" EXACT RESID-name []
synonym: "HemeCys2" EXACT PSI-MOD-label []
xref: DiffAvg: "616.50"
xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4 S 0"
xref: DiffMono: "616.177293"
xref: Formula: "C 40 Fe 1 H 42 N 6 O 6 S 2"
xref: MassAvg: "822.78"
xref: MassMono: "822.195663"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00699 ! porphyrin modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00144
name: heme-L-cysteine
def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [ChEBI:17627, DeltaMass:0, PubMed:170910, PubMed:192772, PubMed:2536325, PubMed:9535866, RESID:AA0135, Unimod:390#C]
comment: From DeltaMass: Average Mass: 617.
subset: PSI-MOD-slim
synonym: "(12-ethenyl-7-[(1S)-1-([(2R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis[2-carboxyethyl]-N21,N22,N23,N24)-ferrate" EXACT RESID-systematic []
synonym: "4-[1-(S-cysteinyl)ethyl]protoporphyrin IX" EXACT RESID-alternate []
synonym: "BINDING Heme (covalent; via 1 link)" EXACT UniProt-feature []
synonym: "cysteinyl heme" EXACT RESID-alternate []
synonym: "Heme" RELATED PSI-MS-label []
synonym: "heme" RELATED Unimod-description []
synonym: "heme-L-cysteine" EXACT RESID-name []
synonym: "HemeCys1" EXACT PSI-MOD-label []
synonym: "S-Heme (on Cysteine)" EXACT DeltaMass-label []
xref: DiffAvg: "616.50"
xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4 S 0"
xref: DiffMono: "616.177293"
xref: Formula: "C 37 Fe 1 H 37 N 5 O 5 S 1"
xref: MassAvg: "719.64"
xref: MassMono: "719.186478"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:390"
is_a: MOD:00699 ! porphyrin modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00145
name: tetrakis-L-cysteinyl iron
def: "A protein modification that effectively converts four L-cysteine residues iron atom to tetrakis-L-cysteinyl iron." [PubMed:1303768, PubMed:2244884, RESID:AA0136]
comment: Cross-link 4.
synonym: "METAL Iron" EXACT UniProt-feature []
synonym: "tetrakis(cysteinato-kappaS)-iron" EXACT RESID-systematic []
synonym: "tetrakis-L-cysteinyl iron" EXACT RESID-name []
xref: DiffAvg: "51.81"
xref: DiffFormula: "C 0 Fe 1 H -4 N 0 O 0 S 0"
xref: DiffMono: "51.904735"
xref: FormalCharge: "2-"
xref: Formula: "C 12 Fe 1 H 16 N 4 O 4 S 4"
xref: MassAvg: "464.37"
xref: MassMono: "463.941474"
xref: Origin: "C, C, C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00738 ! iron containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00146
name: tetrakis-L-cysteinyl diiron disulfide
def: "A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to tetrakis-L-cysteinyl diiron disulfide." [PubMed:2123937, PubMed:6801028, PubMed:7763242, PubMed:8688437, RESID:AA0137]
comment: Cross-link 4.
synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature []
synonym: "METAL Iron-sulfur (2Fe-2S); shared with dimeric partner" EXACT UniProt-feature []
synonym: "tetrakis-L-cysteinyl diiron disulfide" EXACT RESID-name []
synonym: "tetrakiscysteinato-1kappa(2)S,2kappa(2)S-di-mu-sulfido-diiron" EXACT RESID-systematic []
xref: DiffAvg: "171.78"
xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2"
xref: DiffMono: "171.783814"
xref: FormalCharge: "2-"
xref: Formula: "C 12 Fe 2 H 16 N 4 O 4 S 6"
xref: MassAvg: "584.34"
xref: MassMono: "583.820553"
xref: Origin: "C, C, C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00147
name: hexakis-L-cysteinyl triiron trisulfide
def: "A protein modification that effectively converts six L-cysteine residues and a three-iron three-sulfur cluster to hexakis-L-cysteinyl triiron trisulfide." [PubMed:3379067, PubMed:3932661, PubMed:7354058, RESID:AA0138]
comment: Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "hexakis-L-cysteinyl triiron trisulfide" EXACT RESID-name []
synonym: "tri-mu-sulfido-hexakiscysteinato-1kappa(2)S,2kappa(2)S,3kappa(2)S-triiron" EXACT RESID-systematic []
synonym: "tri-mu-sulfidotris(biscysteinato-kappaS-iron)" EXACT RESID-alternate []
xref: DiffAvg: "257.67"
xref: DiffFormula: "C 0 Fe 3 H -6 N 0 O 0 S 3"
xref: DiffMono: "257.675721"
xref: FormalCharge: "3-"
xref: Formula: "C 18 Fe 3 H 24 N 6 O 6 S 9"
xref: MassAvg: "876.50"
xref: MassMono: "875.730830"
xref: Origin: "C, C, C, C, C, C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00148
name: tris-L-cysteinyl triiron tetrasulfide
def: "A protein modification that effectively converts three L-cysteine residues and a three-iron four-sulfur cluster to tris-L-cysteinyl triiron tetrasulfide." [PubMed:10555576, PubMed:2056535, PubMed:3422475, PubMed:6848518, PubMed:7819255, PubMed:9063899, RESID:AA0139]
comment: Cross-link 3.
synonym: "METAL Iron-sulfur (3Fe-4S)" EXACT UniProt-feature []
synonym: "mu3-sulfido tri-mu-sulfido tris-S-L-cysteinyl triiron" EXACT RESID-alternate []
synonym: "mu3-sulfido-tri-mu-sulfido-triscysteinato-1kappaS,2kappaS,3kappaS-triiron" EXACT RESID-systematic []
synonym: "tris-L-cysteinyl triiron tetrasulfide" EXACT RESID-name []
synonym: "tris-L-cysteinyl triiron tetrasulfide C3 cluster" EXACT RESID-alternate []
synonym: "tris-L-cysteinyl triiron tetrasulfide cubane form" EXACT RESID-alternate []
synonym: "tris-L-cysteinyl triiron tetrasulfide cuboid cluster" EXACT RESID-alternate []
synonym: "tris-L-cysteinyl triiron tetrasulfide trigonal cluster" EXACT RESID-alternate []
xref: DiffAvg: "292.75"
xref: DiffFormula: "C 0 Fe 3 H -3 N 0 O 0 S 4"
xref: DiffMono: "292.671267"
xref: FormalCharge: "3-"
xref: Formula: "C 9 Fe 3 H 12 N 3 O 3 S 7"
xref: MassAvg: "602.17"
xref: MassMono: "601.698821"
xref: Origin: "C, C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00149
name: tetrakis-L-cysteinyl tetrairon tetrasulfide
def: "A protein modification that effectively converts four L-cysteine residues and a four-iron four-sulfur cluster to tetrakis-L-cysteinyl tetrairon tetrasulfide." [PubMed:3351918, PubMed:7803404, PubMed:7819196, PubMed:932007, RESID:AA0140]
comment: Cross-link 4.
synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature []
synonym: "METAL Iron-sulfur (4Fe-4S); shared with dimeric partner" EXACT UniProt-feature []
synonym: "tetra-mu3-sulfido-tetrakis(cysteinato)-1kappaS,2kappaS,3kappaS,4kappaS-tetrahedro-tetrairon" EXACT RESID-systematic []
synonym: "tetra-mu3-sulfidotetrakis(S-cysteinyliron)" EXACT RESID-alternate []
synonym: "tetrakis-L-cysteinyl tetrairon tetrasulfide" EXACT RESID-name []
xref: DiffAvg: "347.59"
xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4"
xref: DiffMono: "347.597831"
xref: FormalCharge: "2-"
xref: Formula: "C 12 Fe 4 H 16 N 4 O 4 S 8"
xref: MassAvg: "760.15"
xref: MassMono: "759.634570"
xref: Origin: "C, C, C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00150
name: L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide
def: "A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-molybdenum seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide." [PubMed:10525412, PubMed:12215645, PubMed:12733878, PubMed:1529354, PubMed:8027059, RESID:AA0141]
comment: Cross-link 2; incidental to RESID:AA0300.
synonym: "cysteinato-8kappaS-histidino-1kappaN(tau)-[(2R)-4-carboxy-2-(carboxymethyl)-2-oxidobutanoate-1kappaO(1),1kappaO(2)]-mu6-carbido-2:3:4:5:6:7kappa(6)C-hexa-mu3-sulfido-1:2:3kappa(3)S;1:2:4kappa(3)S;1:3:4kappa(3)S;5:6:8kappa(3)S;5:7:8kappa(3)S;6:7:8kappa(3)S-tri-mu2-sulfido-2:5kappa(2)S;3:6kappa(2)S;4:7kappa(2)S molybdenum heptairon" EXACT RESID-systematic []
synonym: "L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide carbide" EXACT RESID-name []
synonym: "nitrogenase iron-molybdenum cofactor" EXACT RESID-alternate []
xref: DiffAvg: "991.53"
xref: DiffFormula: "C 7 Fe 7 H 6 Mo 1 N 1 O 7 S 9"
xref: DiffMono: "993.213036"
xref: Formula: "C 16 Fe 7 H 18 Mo 1 N 5 O 9 S 10"
xref: MassAvg: "1231.81"
xref: MassMono: "1233.281133"
xref: Origin: "C, H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:00743 ! molybdenum containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00151
name: L-cysteinyl molybdopterin
def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdopterin." [PubMed:14527393, PubMed:7878465, PubMed:9428520, RESID:AA0142, Unimod:391#C]
subset: PSI-MOD-slim
synonym: "(4R,5aR,11aR)-8-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-4,5a,6,9,10,11,11a-heptahydro-4-(phosphoric acid)methyl-2,2,10-trioxo-pteridino[6,7-5,6]pyrano[3,4-4,3][1,2,5]molybdadithiolene" EXACT RESID-systematic []
synonym: "cysteinyl Mo-molybdopterin" EXACT RESID-alternate []
synonym: "cysteinyl Mo-pterin" EXACT RESID-alternate []
synonym: "L-cysteinyl molybdopterin" EXACT RESID-name []
synonym: "METAL Molybdenum-pterin" EXACT UniProt-feature []
synonym: "molybdoenzyme molybdenum cofactor" EXACT RESID-alternate []
synonym: "Molybdopterin" RELATED PSI-MS-label []
synonym: "molybdopterin" RELATED Unimod-description []
synonym: "MoPterCys" EXACT PSI-MOD-label []
xref: DiffAvg: "520.27"
xref: DiffFormula: "C 10 H 11 Mo 1 N 5 O 8 P 1 S 2"
xref: DiffMono: "521.884074"
xref: Formula: "C 13 H 16 Mo 1 N 6 O 9 P 1 S 3"
xref: MassAvg: "623.41"
xref: MassMono: "624.893259"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:391"
is_a: MOD:00744 ! molybdenum pterin containing modification
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00152
name: S-(8alpha-FAD)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S'-(8alpha-FAD)-L-cystine." [PubMed:10220347, RESID:AA0143, Unimod:50#C]
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "8alpha-(S-cysteinyl)FAD" EXACT RESID-alternate []
synonym: "FAD" RELATED PSI-MS-label []
synonym: "Flavin adenine dinucleotide" RELATED Unimod-description []
synonym: "MOD_RES S-8alpha-FAD cysteine" EXACT UniProt-feature []
synonym: "S-(8alpha-FAD)-L-cysteine" EXACT RESID-name []
synonym: "S8aFADCys" EXACT PSI-MOD-label []
xref: DiffAvg: "783.54"
xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2 S 0"
xref: DiffMono: "783.141485"
xref: Formula: "C 30 H 36 N 10 O 16 P 2 S 1"
xref: MassAvg: "886.68"
xref: MassMono: "886.150669"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:50"
xref: uniprot.ptm:PTM-0272
is_a: MOD:00895 ! FAD modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00153
name: 3'-(8alpha-FAD)-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FAD)-L-histidine." [PubMed:241294, PubMed:8076, RESID:AA0144, Unimod:50#H]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(3-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid" EXACT RESID-systematic []
synonym: "3'-(8alpha-FAD)-L-histidine" EXACT RESID-name []
synonym: "8alpha-(N(delta)-histidyl)FAD" EXACT RESID-alternate []
synonym: "8alpha-(N3'-histidyl)FAD" EXACT RESID-alternate []
synonym: "8alpha-N1-histidyl FAD" RELATED RESID-misnomer []
synonym: "FAD" RELATED PSI-MS-label []
synonym: "Flavin adenine dinucleotide" RELATED Unimod-description []
synonym: "MOD_RES Pros-8alpha-FAD histidine" EXACT UniProt-feature []
synonym: "N(pi)-(8alpha-FAD)-histidine" EXACT RESID-alternate []
synonym: "Np8aFADHis" EXACT PSI-MOD-label []
synonym: "pros-(8alpha-FAD)-histidine" EXACT RESID-alternate []
xref: DiffAvg: "783.54"
xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2"
xref: DiffMono: "783.141485"
xref: Formula: "C 33 H 38 N 12 O 16 P 2"
xref: MassAvg: "920.68"
xref: MassMono: "920.200396"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:50"
xref: uniprot.ptm:PTM-0258
is_a: MOD:00895 ! FAD modified residue
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:00154
name: O4'-(8alpha-FAD)-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to O4'-(8alpha-FAD)-L-tyrosine." [DeltaMass:0, PubMed:7391034, RESID:AA0145, Unimod:50#Y]
comment: From DeltaMass: Average Mass: 783
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "8alpha-(O4'-tyrosyl)FAD" EXACT RESID-alternate []
synonym: "FAD" RELATED PSI-MS-label []
synonym: "Flavin adenine dinucleotide" RELATED Unimod-description []
synonym: "MOD_RES O-8alpha-FAD tyrosine" EXACT UniProt-feature []
synonym: "O-8 alpha-Flavin [FAD])- (of Tyrosine)" EXACT DeltaMass-label []
synonym: "O4'-(8alpha-FAD)-L-tyrosine" EXACT RESID-name []
synonym: "O8aFADTyr" EXACT PSI-MOD-label []
xref: DiffAvg: "783.54"
xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2"
xref: DiffMono: "783.141485"
xref: Formula: "C 36 H 40 N 10 O 17 P 2"
xref: MassAvg: "946.72"
xref: MassMono: "946.204813"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:50"
xref: uniprot.ptm:PTM-0231
is_a: MOD:00895 ! FAD modified residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00155
name: L-3',4'-dihydroxyphenylalanine
def: "A protein modification that effectively converts an L-tyrosine residue to L-3',4'-dihydroxyphenylalanine." [DeltaMass:0, OMSSA:194, OMSSA:64, PubMed:1610822, PubMed:1903612, PubMed:3734192, RESID:AA0146, Unimod:35#Y, ChEBI:141815]
comment: incidental to RESID:AA0368 From DeltaMass: Average Mass: 16
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "3,4-Dihydroxy-Phenylalanine (from Tyrosine) (DOPA)" EXACT DeltaMass-label []
synonym: "3HyTyr" EXACT PSI-MOD-label []
synonym: "hydroxylationy" EXACT OMSSA-label []
synonym: "L-3',4'-dihydroxyphenylalanine" EXACT RESID-name []
synonym: "L-3'-hydroxytyrosine" EXACT RESID-alternate []
synonym: "L-DOPA" EXACT RESID-alternate []
synonym: "levodopa" EXACT RESID-alternate []
synonym: "mod194" EXACT OMSSA-label []
synonym: "MOD_RES 3',4'-dihydroxyphenylalanine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 9 H 9 N 1 O 3"
xref: MassAvg: "179.18"
xref: MassMono: "179.058243"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:35"
xref: uniprot.ptm:PTM-0023
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:00707 ! hydroxylated tyrosine

[Term]
id: MOD:00156
name: L-2',4',5'-topaquinone
def: "A protein modification that effectively converts an L-tyrosine residue to an L-2',4',5'-topaquinone." [ChEBI:21187, PubMed:10387067, PubMed:1457410, PubMed:1569055, PubMed:2111581, RESID:AA0147, Unimod:392#Y]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(5-hydroxy-2,5-cyclohexadien-1,4-dion-2-yl)propanoic acid" EXACT RESID-systematic []
synonym: "2,4,5-trihydroxyphenylalanine quinone" EXACT RESID-alternate []
synonym: "5-(2-carboxy-2-aminoethyl)-2-hydroxy-1,4-benzoquinone" EXACT RESID-alternate []
synonym: "L-2',4',5'-topaquinone" EXACT RESID-name []
synonym: "L-2,4,5-TOPAquinone" EXACT RESID-alternate []
synonym: "MOD_RES 2',4',5'-topaquinone" EXACT UniProt-feature []
synonym: "Quinone" RELATED PSI-MS-label []
synonym: "quinone" RELATED Unimod-description []
synonym: "TopaQ" EXACT PSI-MOD-label []
synonym: "TPQ" EXACT RESID-alternate []
xref: DiffAvg: "29.98"
xref: DiffFormula: "C 0 H -2 N 0 O 2"
xref: DiffMono: "29.974179"
xref: Formula: "C 9 H 7 N 1 O 4"
xref: MassAvg: "193.16"
xref: MassMono: "193.037508"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:392"
xref: uniprot.ptm:PTM-0009
is_a: MOD:00679 ! carbon oxygenated residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00157
name: L-tryptophyl quinone
def: "A protein modification that effectively converts an L-tryptophan residue to an L-tryptophan quinone." [DeltaMass:0, PubMed:2028257, RESID:AA0148, Unimod:392#W]
comment: incidental to RESID:AA0149; incidental to RESID:AA0313; From DeltaMass: Average Mass: 30.
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(6,7-dioxo-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(6,7-dioxo-6,7-dihydro-1H-indol-3-yl)-propionic acid" EXACT RESID-alternate []
synonym: "3-[(2S)-2-amino-2-carboxyethyl]-6,7-indolinedione" EXACT RESID-alternate []
synonym: "6,7 Dione (from Tryptophan)" EXACT DeltaMass-label []
synonym: "L-tryptophyl quinone" EXACT RESID-name []
synonym: "MOD_RES Tryptophylquinone" EXACT UniProt-feature []
synonym: "N-(3-carboxy-1-oxopropyl)-L-tryptophan" EXACT RESID-alternate []
synonym: "Quinone" RELATED PSI-MS-label []
synonym: "quinone" RELATED Unimod-description []
synonym: "TrpQ" EXACT PSI-MOD-label []
xref: DiffAvg: "29.98"
xref: DiffFormula: "C 0 H -2 N 0 O 2"
xref: DiffMono: "29.974179"
xref: Formula: "C 11 H 8 N 2 O 3"
xref: MassAvg: "216.20"
xref: MassMono: "216.053492"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:392"
xref: uniprot.ptm:PTM-0299
is_a: MOD:00679 ! carbon oxygenated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:00158
name: 4'-(L-tryptophan)-L-tryptophyl quinone
def: "A protein modification that effectively cross-links two L-tryptophan residues by a carbon-carbon bond to form 4'-(L-tryptophan)-L-tryptophyl quinone." [ChEBI:20251, DeltaMass:0, PubMed:2028257, RESID:AA0149]
comment: Cross-link 2; secondary to RESID:AA0148; From DeltaMass: Average Mass: 28.
subset: PSI-MOD-slim
synonym: "2,4-BisTrp-6,7-dione (from Tryptophan)" EXACT DeltaMass-label []
synonym: "2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-6,7-dioxo-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid" EXACT RESID-alternate []
synonym: "3-[(2S)-2-amino-2-carboxyethyl]-4-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-6,7-indolinedione" EXACT RESID-systematic []
synonym: "4'-tryptophan-tryptophylquinone" EXACT RESID-alternate []
synonym: "4-(2'-tryptophyl)tryptophan-6,7-dione" EXACT RESID-alternate []
synonym: "4-(L-tryptophan-2-yl)-L-tryptophyl quinone" EXACT RESID-name []
synonym: "alpha,alpha'-diamino-6',7'-dihydro-6',7'-dioxo-(2,4'-bi-1H-indole)-3,3'-dipropanoic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Tryptophan tryptophylquinone (Trp-Trp)" EXACT UniProt-feature []
synonym: "TTQ" EXACT RESID-alternate []
synonym: "XLNK-4'Trp-TrpQ" EXACT PSI-MOD-label []
xref: DiffAvg: "27.97"
xref: DiffFormula: "C 0 H -4 N 0 O 2"
xref: DiffMono: "27.958529"
xref: Formula: "C 22 H 16 N 4 O 4"
xref: MassAvg: "400.39"
xref: MassMono: "400.117155"
xref: Origin: "W, W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0298
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02057 ! crosslinked L-tryptophan residue

[Term]
id: MOD:00159
name: O-phosphopantetheine-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-phosphopantetheine-L-serine." [DeltaMass:0, PubMed:10320345, PubMed:10997907, PubMed:12057197, PubMed:12869567, PubMed:4568609, RESID:AA0150, Unimod:49#S]
comment: Unimod has DiffFormula C 11 H 20 N 2 O 6 P 1 S 1 From DeltaMass: Average Mass: 339
subset: PSI-MOD-slim
synonym: "(2R)-2-hydroxy-3,3-dimethyl-4-[(2S)-2-amino-2-carboxyethyl]phosphonato-N-(3-oxo-3-[(2-sulfanylethyl)amino]propyl)butanamide" EXACT RESID-systematic []
synonym: "4'-Phosphopantetheine" EXACT DeltaMass-label []
synonym: "MOD_RES O-(pantetheine 4'-phosphoryl)serine" EXACT UniProt-feature []
synonym: "O-phosphopantetheine-L-serine" EXACT RESID-name []
synonym: "OPpantSer" EXACT PSI-MOD-label []
synonym: "Phosphopantetheine" RELATED PSI-MS-label []
synonym: "Phosphopantetheine" RELATED Unimod-description []
xref: DiffAvg: "340.33"
xref: DiffFormula: "C 11 H 21 N 2 O 6 P 1 S 1"
xref: DiffMono: "340.085794"
xref: Formula: "C 14 H 26 N 3 O 8 P 1 S 1"
xref: MassAvg: "427.41"
xref: MassMono: "427.117822"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:49"
xref: uniprot.ptm:PTM-0391
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00160
name: N4-glycosyl-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine." [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var]
subset: PSI-MOD-slim
synonym: "N4GlycoAsn" EXACT PSI-MOD-label []
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00006 ! N-glycosylated residue
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:00161
name: S-glucosyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-glucosylated L-cysteine." [PubMed:1145128, PubMed:15279557, PubMed:5286858, RESID:AA0152, Unimod:41#C]
synonym: "(2R)-2-amino-3-[(beta-D-glucopyranosyl)sulfanyl]propanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD S-linked (Glc) cysteine" EXACT UniProt-feature []
synonym: "Hex" RELATED PSI-MS-label []
synonym: "Hexose" RELATED Unimod-description []
synonym: "S-(beta-D-glucopyranosyl)cysteine" EXACT RESID-alternate []
synonym: "S-glucosyl-L-cysteine" EXACT RESID-name []
synonym: "S-glycosyl-cysteine" EXACT RESID-alternate []
synonym: "SGlcCys" EXACT PSI-MOD-label []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5 S 0"
xref: DiffMono: "162.052823"
xref: Formula: "C 9 H 15 N 1 O 6 S 1"
xref: MassAvg: "265.28"
xref: MassMono: "265.062008"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:41"
xref: uniprot.ptm:PTM-0626
is_a: MOD:00426 ! S-glycosylated residue
is_a: MOD:00433 ! monoglucosylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00162
name: O5-glucosylgalactosyl-L-hydroxylysine
def: "A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine." [PubMed:15149698, PubMed:4288358, PubMed:4319110, RESID:AA0153, Unimod:393]
comment: Secondary to RESID:AA0028.
subset: PSI-MOD-slim
synonym: "(2S,5R)-2,6-diamino-5-[2-O-(alpha-D-glucopyranosyl)-beta-D-galactopyranosyloxy]hexanoic acid" EXACT RESID-systematic []
synonym: "5-(2-O-alpha-D-glucopyranosyl-beta-D-galactopyranosyl)oxy-L-lysine" EXACT RESID-alternate []
synonym: "Glucosylgalactosyl" RELATED PSI-MS-label []
synonym: "glucosylgalactosyl hydroxylysine" RELATED Unimod-description []
synonym: "O5-glucosylgalactosyl-L-hydroxylysine" EXACT RESID-name []
synonym: "OGlcGal5HyLys" EXACT PSI-MOD-label []
xref: DiffAvg: "340.28"
xref: DiffFormula: "C 12 H 20 N 0 O 11"
xref: DiffMono: "340.100561"
xref: Formula: "C 18 H 32 N 2 O 12"
xref: MassAvg: "468.46"
xref: MassMono: "468.195524"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:393"
relationship: derives_from MOD:00037 ! 5-hydroxy-L-lysine
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:00396 ! O-glycosylated residue

[Term]
id: MOD:00163
name: O-(N-acetylamino)galactosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine." [PubMed:115869, PubMed:16005634, PubMed:3086323, PubMed:8948436, PubMed:9092502, RESID:AA0154]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (GalNAc) serine" EXACT UniProt-feature []
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "mucin type O-glycosylserine" EXACT RESID-alternate []
synonym: "O-(N-acetylamino)galactosyl-L-serine" EXACT RESID-name []
synonym: "O3-(N-acetylgalactosaminyl)serine" EXACT RESID-alternate []
synonym: "OGalNAcSer" EXACT PSI-MOD-label []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "C 11 H 18 N 2 O 7"
xref: MassAvg: "290.27"
xref: MassMono: "290.111401"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0564
is_a: MOD:00563 ! mono-N-acetylaminogalactosylated residue
is_a: MOD:01675 ! O-(N-acetylamino)hexosyl-L-serine

[Term]
id: MOD:00164
name: O-(N-acetylamino)galactosyl-L-threonine
def: "A protein modification that effectively converts an L-asparagine residue to O-(N-acetylaminogalactosyl)-L-threonine." [PubMed:16005634, PubMed:1997327, PubMed:3086323, PubMed:8948436, PubMed:9092502, RESID:AA0155]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-(2-acetamido-2-deoxy-alpha-D-galactopyranosyloxy)butanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (GalNAc) threonine" EXACT UniProt-feature []
synonym: "CARBOHYD O-linked (HexNAc)" EXACT UniProt-feature []
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "mucin type O-glycosylthreonine" EXACT RESID-alternate []
synonym: "O-(N-acetylamino)galactosyl-L-threonine" EXACT RESID-name []
synonym: "O3-(N-acetylgalactosaminyl)threonine" EXACT RESID-alternate []
synonym: "OGalNAcThr" EXACT PSI-MOD-label []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "C 12 H 20 N 2 O 7"
xref: MassAvg: "304.30"
xref: MassMono: "304.127051"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0567
is_a: MOD:00563 ! mono-N-acetylaminogalactosylated residue
is_a: MOD:01676 ! O-(N-acetylamino)hexosyl-L-threonine

[Term]
id: MOD:00165
name: 1'-mannosyl-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to 1'-mannosyl-L-tryptophan." [PubMed:1482345, PubMed:16150691, RESID:AA0156]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "1'-glycosyl-L-tryptophan" EXACT RESID-alternate []
synonym: "1'-mannosyl-L-tryptophan" EXACT RESID-name []
synonym: "CARBOHYD N-linked (Man) tryptophan" EXACT UniProt-feature []
synonym: "N-mannosyl-tryptophan" EXACT RESID-alternate []
synonym: "N1'ManTrp" EXACT PSI-MOD-label []
synonym: "N1-mannosyl-tryptophan" EXACT RESID-alternate []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 17 H 20 N 2 O 6"
xref: MassAvg: "348.36"
xref: MassMono: "348.132136"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0535
is_a: MOD:00006 ! N-glycosylated residue
is_a: MOD:00595 ! monomannosylated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:00166
name: O4'-glucosyl-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to O4'-glucosyl-tyrosine." [PubMed:15279557, PubMed:3181138, RESID:AA0157, Unimod:41#Y]
synonym: "(2S)-2-amino-3-(4-alpha-D-glucopyranosyloxy)phenylpropanoic acid" EXACT RESID-systematic []
synonym: "Hex" RELATED PSI-MS-label []
synonym: "Hexose" RELATED Unimod-description []
synonym: "O4'-glucosyl-L-tyrosine" EXACT RESID-name []
synonym: "O4'-glycosyl-L-tyrosine" EXACT RESID-alternate []
synonym: "O4GlcTyr" EXACT PSI-MOD-label []
synonym: "CARBOHYD O-linked (Glc) tyrosine" EXACT UniProt-feature []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 15 H 19 N 1 O 7"
xref: MassAvg: "325.32"
xref: MassMono: "325.116152"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:41"
xref: uniprot.ptm:PTM-0575
is_a: MOD:00433 ! monoglucosylated residue
is_a: MOD:01927 ! O-glycosyl-L-tyrosine

[Term]
id: MOD:00167
name: N-asparaginyl-glycosylphosphatidylinositolethanolamine
def: "A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylphosphatidylinositolethanolamine." [PubMed:1824714, PubMed:8276756, RESID:AA0158]
synonym: "GPIAsn" EXACT PSI-MOD-label []
synonym: "LIPID GPI-anchor amidated asparagine" EXACT UniProt-feature []
synonym: "N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 6 H 13 N 3 O 6 P 1"
xref: MassAvg: "254.16"
xref: MassMono: "254.054197"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0137
is_a: MOD:00818 ! glycosylphosphatidylinositolated residue
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:00168
name: N-aspartyl-glycosylphosphatidylinositolethanolamine
def: "A protein modification that effectively converts an L-aspartic acid residue to N-(aspart-1-yl)-glycosylphosphatidylinositolethanolamine." [PubMed:7120400, RESID:AA0159]
synonym: "GPIAsp" EXACT PSI-MOD-label []
synonym: "LIPID GPI-anchor amidated aspartate" EXACT UniProt-feature []
synonym: "N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 6 H 12 N 2 O 7 P 1"
xref: MassAvg: "255.14"
xref: MassMono: "255.038212"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0138
is_a: MOD:00818 ! glycosylphosphatidylinositolated residue
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:00169
name: N-cysteinyl-glycosylphosphatidylinositolethanolamine
def: "A protein modification that effectively converts an L-cysteine residue to N-cysteinyl-glycosylphosphatidylinositolethanolamine." [PubMed:2897081, RESID:AA0160]
synonym: "GPICys" EXACT PSI-MOD-label []
synonym: "LIPID GPI-anchor amidated cysteine" EXACT UniProt-feature []
synonym: "N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1 S 0"
xref: DiffMono: "123.008530"
xref: Formula: "C 5 H 12 N 2 O 5 P 1 S 1"
xref: MassAvg: "243.19"
xref: MassMono: "243.020454"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0140
is_a: MOD:00818 ! glycosylphosphatidylinositolated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00170
name: N-glycyl-glycosylphosphatidylinositolethanolamine
def: "A protein modification that effectively converts a glycine residue to N-glycyl-glycosylphosphatidylinositolethanolamine." [PubMed:2341397, RESID:AA0161]
synonym: "GPIGly" EXACT PSI-MOD-label []
synonym: "LIPID GPI-anchor amidated glycine" EXACT UniProt-feature []
synonym: "N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 4 H 10 N 2 O 5 P 1"
xref: MassAvg: "197.11"
xref: MassMono: "197.032733"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0141
is_a: MOD:00818 ! glycosylphosphatidylinositolated residue
is_a: MOD:00908 ! modified glycine residue

[Term]
id: MOD:00171
name: N-seryl-glycosylphosphatidylinositolethanolamine
def: "A protein modification that effectively converts an L-serine residue to N-seryl-glycosylphosphatidylinositolethanolamine." [PubMed:2111324, PubMed:8448158, RESID:AA0162]
synonym: "GPISer" EXACT PSI-MOD-label []
synonym: "LIPID GPI-anchor amidated serine" EXACT UniProt-feature []
synonym: "N-seryl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 5 H 12 N 2 O 6 P 1"
xref: MassAvg: "227.13"
xref: MassMono: "227.043298"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0142
is_a: MOD:00818 ! glycosylphosphatidylinositolated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00172
name: N-alanyl-glycosylphosphatidylinositolethanolamine
def: "A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylphosphatidylinositolethanolamine." [PubMed:7682556, PubMed:7744038, RESID:AA0163]
synonym: "GPIAla" EXACT PSI-MOD-label []
synonym: "LIPID GPI-anchor amidated alanine" EXACT UniProt-feature []
synonym: "N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 5 H 12 N 2 O 5 P 1"
xref: MassAvg: "211.13"
xref: MassMono: "211.048383"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0136
is_a: MOD:00818 ! glycosylphosphatidylinositolated residue
is_a: MOD:00901 ! modified L-alanine residue

[Term]
id: MOD:00173
name: N-threonyl-glycosylphosphatidylinositolethanolamine
def: "A protein modification that effectively converts an L-threonine residue to N-threonyl-glycosylphosphatidylinositolethanolamine." [RESID:AA0164]
synonym: "GPIThr" EXACT PSI-MOD-label []
synonym: "LIPID GPI-anchor amidated threonine" EXACT UniProt-feature []
synonym: "N-threonyl-glycosylphosphatidylinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 6 H 14 N 2 O 6 P 1"
xref: MassAvg: "241.16"
xref: MassMono: "241.058948"
xref: Origin: "T"
xref: Source: "hypothetical"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0143
is_a: MOD:00818 ! glycosylphosphatidylinositolated residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:00174
name: N-glycyl-glycosylsphingolipidinositolethanolamine
def: "A protein modification that effectively converts a glycine residue to N-glycyl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, PubMed:8404891, RESID:AA0165]
synonym: "GSIGly" EXACT PSI-MOD-label []
synonym: "LIPID GPI-like-anchor amidated glycine" EXACT UniProt-feature []
synonym: "N-glycyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 4 H 10 N 2 O 5 P 1"
xref: MassAvg: "197.11"
xref: MassMono: "197.032733"
xref: Origin: "G"
xref: Source: "hypothetical"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0146
is_a: MOD:00466 ! glycosylsphingolipidinositolated residue
is_a: MOD:00908 ! modified glycine residue

[Term]
id: MOD:00175
name: N-seryl-glycosylsphingolipidinositolethanolamine
def: "A protein modification that effectively converts an L-serine residue to N-seryl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, PubMed:2721485, PubMed:8269952, RESID:AA0166]
synonym: "GSISer" EXACT PSI-MOD-label []
synonym: "LIPID GPI-like-anchor amidated serine" EXACT UniProt-feature []
synonym: "N-seryl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 5 H 12 N 2 O 6 P 1"
xref: MassAvg: "227.13"
xref: MassMono: "227.043298"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0147
is_a: MOD:00466 ! glycosylsphingolipidinositolated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00176
name: O-(phosphoribosyl dephospho-coenzyme A)-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-(phosphoribosyl dephospho-coenzyme A)-L-serine." [PubMed:10924139, PubMed:11052675, PubMed:179809, PubMed:180526, PubMed:368065, RESID:AA0167, Unimod:395#S]
comment: pRibodePcoA
subset: PSI-MOD-slim
synonym: "MOD_RES O-(phosphoribosyl dephospho-coenzyme A)serine" EXACT UniProt-feature []
synonym: "O-(phosphoribosyl dephospho-coenzyme A)-L-serine" EXACT RESID-name []
synonym: "O3-(phosphate-5-ribosyl-alpha-2-adenosine-5-diphosphate pantetheine)-L-serine" EXACT RESID-alternate []
synonym: "O3-(phosphoribosyl dephospho-coenzyme A)-L-serine" EXACT RESID-alternate []
synonym: "O3-2'-(5''-phosphoribosyl-3'-dephosphocoenzyme A)-L-serine" EXACT RESID-alternate []
synonym: "OPRibdPCoASer" EXACT PSI-MOD-label []
synonym: "phosphoribosyl dephospho-coenzyme A" RELATED Unimod-description []
synonym: "PhosphoribosyldephosphoCoA" RELATED PSI-MS-label []
xref: DiffAvg: "881.63"
xref: DiffFormula: "C 26 H 42 N 7 O 19 P 3 S 1"
xref: DiffMono: "881.146903"
xref: Formula: "C 29 H 47 N 8 O 21 P 3 S 1"
xref: MassAvg: "968.71"
xref: MassMono: "968.178931"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:395"
xref: uniprot.ptm:PTM-0389
is_a: MOD:00860 ! sulfur containing modified residue
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00177
name: omega-N-(ADP-ribosyl)-L-arginine
def: "A protein modification that effectively converts an L-argininine residue to omega-N-(ADP-ribosyl)-L-arginine." [DeltaMass:0, PubMed:15842200, PubMed:209022, PubMed:3090031, PubMed:3923473, PubMed:6582062, RESID:AA0168, Unimod:213#R]
comment: From DeltaMass: Average Mass: 541.
subset: PSI-MOD-slim
synonym: "(S)-2-amino-5-([imino([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)methyl]amino)pentanoic acid" EXACT RESID-systematic []
synonym: "ADP Ribose addition" RELATED Unimod-description []
synonym: "ADP-Ribosyl" RELATED PSI-MS-label []
synonym: "ADPRibArg" EXACT PSI-MOD-label []
synonym: "MOD_RES ADP-ribosylarginine" EXACT UniProt-feature []
synonym: "N(omega)-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-arginine" EXACT RESID-alternate []
synonym: "N(omega)-alpha-D-ribofuranosyl-L-arginine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate []
synonym: "N-(ADP-ribosyl)- (on Arginine)" EXACT DeltaMass-label []
synonym: "omega-N-(ADP-ribosyl)-L-arginine" EXACT RESID-name []
xref: DiffAvg: "541.30"
xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2"
xref: DiffMono: "541.061109"
xref: Formula: "C 21 H 33 N 9 O 14 P 2"
xref: MassAvg: "697.49"
xref: MassMono: "697.162220"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:213"
xref: uniprot.ptm:PTM-0053
is_a: MOD:00752 ! monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00178
name: S-(ADP-ribosyl)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(ADP-ribosyl)-L-cysteine." [DeltaMass:0, PubMed:15842200, PubMed:3863818, RESID:AA0169, Unimod:213#C]
comment: From DeltaMass: Average Mass: 541.
subset: PSI-MOD-slim
synonym: "(R)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "ADP Ribose addition" RELATED Unimod-description []
synonym: "ADP-Ribosyl" RELATED PSI-MS-label []
synonym: "ADPRibCys" EXACT PSI-MOD-label []
synonym: "MOD_RES ADP-ribosylcysteine" EXACT UniProt-feature []
synonym: "S-(ADP-ribosyl)- (on Cysteine)" EXACT DeltaMass-label []
synonym: "S-(ADP-ribosyl)-L-cysteine" EXACT RESID-name []
synonym: "S-alpha-D-ribofuranosyl-L-cysteine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate []
synonym: "S-L-cysteine alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate []
xref: DiffAvg: "541.30"
xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2 S 0"
xref: DiffMono: "541.061109"
xref: Formula: "C 18 H 26 N 6 O 14 P 2 S 1"
xref: MassAvg: "644.44"
xref: MassMono: "644.070294"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:213"
xref: uniprot.ptm:PTM-0055
is_a: MOD:00752 ! monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00179
name: L-glutamyl 5-glycerylphosphorylethanolamine
def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-glycerylphosphorylethanolamine." [PubMed:2511205, PubMed:2569467, PubMed:9662537, RESID:AA0170, Unimod:396#E]
comment: glycerylPE
subset: PSI-MOD-slim
synonym: "(S)-2-amino-5-[2-([([2,3-dihydroxypropyl]oxy)(hydroxy)phosphoryl]oxy)ethyl]amino-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "5-L-glutamyl glycerylphosphorylethanolamine" EXACT RESID-name []
synonym: "5GlyceroPEtAGlu" EXACT PSI-MOD-label []
synonym: "GlycerylPE" RELATED PSI-MS-label []
synonym: "glycerylphosphorylethanolamine" RELATED Unimod-description []
synonym: "L-glutamyl 5-glycerophosphoethanolamine" EXACT RESID-alternate []
synonym: "L-glutamyl 5-glycerophosphorylethanolamine" EXACT RESID-alternate []
synonym: "L-glutamyl 5-glycerylphosphorylethanolamine" EXACT RESID-alternate []
synonym: "MOD_RES 5-glutamyl glycerylphosphorylethanolamine" EXACT UniProt-feature []
xref: DiffAvg: "197.13"
xref: DiffFormula: "C 5 H 12 N 1 O 5 P 1"
xref: DiffMono: "197.045309"
xref: Formula: "C 10 H 19 N 2 O 8 P 1"
xref: MassAvg: "326.24"
xref: MassMono: "326.087902"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:396"
xref: uniprot.ptm:PTM-0403
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:00180
name: S-sulfo-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-sulfo-L-cysteine." [PubMed:12876326, PubMed:14752058, PubMed:643076, RESID:AA0171, Unimod:40#C]
synonym: "(2R)-2-amino-3-(sulfosulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(sulfothio)propanoic acid" EXACT RESID-alternate []
synonym: "3-(sulfosulfanyl)-L-alanine" EXACT RESID-alternate []
synonym: "cysteine sulfate thioester" EXACT RESID-alternate []
synonym: "cysteine-S-sulfonic acid" EXACT RESID-alternate []
synonym: "O-Sulfonation" RELATED Unimod-description []
synonym: "S-sulfo-L-cysteine" EXACT RESID-name []
synonym: "S-sulfocysteine" EXACT PSI-MOD-alternate []
synonym: "S-sulfocysteine" EXACT RESID-alternate []
synonym: "SSulfCys" EXACT PSI-MOD-label []
synonym: "Sulfo" RELATED PSI-MS-label []
xref: DiffAvg: "80.06"
xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1"
xref: DiffMono: "79.956815"
xref: Formula: "C 3 H 5 N 1 O 4 S 2"
xref: MassAvg: "183.20"
xref: MassMono: "182.966000"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:40"
is_a: MOD:00695 ! sulfated residue
is_a: MOD:00777 ! residues isobaric at 182.96-182.98 Da
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00181
name: O4'-sulfo-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to O4'-sulfo-L-tyrosine." [DeltaMass:88, OMSSA:114, PubMed:10226369, PubMed:14752058, PubMed:2303439, PubMed:3778455, PubMed:3801003, RESID:AA0172, Unimod:40#Y]
comment: From DeltaMass: Average Mass: 80 Average Mass Change:80 PubMed:9624161.
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-(4-sulfooxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-sulfate" EXACT RESID-alternate []
synonym: "MOD_RES Sulfotyrosine" EXACT UniProt-feature []
synonym: "O-Sulfonation" RELATED Unimod-description []
synonym: "O4'-sulfo-L-tyrosine" EXACT RESID-name []
synonym: "O4-sulfotyrosine" EXACT RESID-alternate []
synonym: "OSulfTyr" EXACT PSI-MOD-label []
synonym: "sulfationy" EXACT OMSSA-label []
synonym: "Sulfo" RELATED PSI-MS-label []
synonym: "Sulphation (of O of Tyrosine)" EXACT DeltaMass-label []
synonym: "tyrosine sulfate" EXACT RESID-alternate []
synonym: "tyrosine-O-sulfonic acid" EXACT RESID-alternate []
synonym: "tyrosine-O-sulphonic acid" EXACT RESID-alternate []
synonym: "Tyrosinyl Sulphate" EXACT DeltaMass-label []
xref: DiffAvg: "80.06"
xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1"
xref: DiffMono: "79.956815"
xref: Formula: "C 9 H 9 N 1 O 5 S 1"
xref: MassAvg: "243.23"
xref: MassMono: "243.020143"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:40"
xref: uniprot.ptm:PTM-0286
is_a: MOD:00695 ! sulfated residue
is_a: MOD:00774 ! residues isobaric at 243.02-243.03 Da
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00182
name: L-bromohistidine
def: "A protein modification that effectively converts an L-histidine residue to L-bromohistidine." [PubMed:2076468, PubMed:9033387, RESID:AA0173, Unimod:340#H]
synonym: "Br1His" EXACT PSI-MOD-label []
synonym: "bromination" RELATED Unimod-description []
synonym: "Bromo" RELATED PSI-MS-label []
synonym: "L-bromohistidine" EXACT RESID-name []
synonym: "MOD_RES Bromohistidine" EXACT UniProt-feature []
xref: DiffAvg: "78.90"
xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0"
xref: DiffMono: "77.910512"
xref: Formula: "Br 1 C 6 H 6 N 3 O 1"
xref: MassAvg: "216.04"
xref: MassMono: "214.969424"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:340"
xref: uniprot.ptm:PTM-0089
is_a: MOD:01049 ! halogenated histidine
is_a: MOD:01912 ! monobrominated residue

[Term]
id: MOD:00183
name: L-2'-bromophenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to L-2'-bromophenylalanine." [DeltaMass:83, PubMed:2059627, PubMed:2076468, PubMed:9033387, RESID:AA0174]
comment: From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa.
synonym: "(S)-2-amino-3-(2-bromophenyl)propanoic acid" EXACT RESID-systematic []
synonym: "2'BrPhe" EXACT PSI-MOD-label []
synonym: "bromination" RELATED Unimod-description []
synonym: "Bromo" RELATED PSI-MS-label []
synonym: "L-2'-bromophenylalanine" EXACT RESID-name []
synonym: "L-o-bromination of Phe with 79Br" EXACT DeltaMass-label []
synonym: "o-bromophenylalanine" EXACT RESID-alternate []
synonym: "ortho-bromophenylalanine" EXACT RESID-alternate []
xref: DiffAvg: "78.90"
xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0"
xref: DiffMono: "77.910512"
xref: Formula: "Br 1 C 9 H 8 N 1 O 1"
xref: MassAvg: "226.07"
xref: MassMono: "224.978926"
xref: Origin: "F"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00972 ! monobrominated L-phenylalanine

[Term]
id: MOD:00184
name: L-3'-bromophenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to L-3'-bromophenylalanine." [PubMed:2076468, PubMed:9033387, RESID:AA0175]
synonym: "(S)-2-amino-3-(3-bromophenyl)propanoic acid" EXACT RESID-systematic []
synonym: "3'BrPhe" EXACT PSI-MOD-label []
synonym: "bromination" RELATED Unimod-description []
synonym: "Bromo" RELATED PSI-MS-label []
synonym: "L-3'-bromophenylalanine" EXACT RESID-name []
synonym: "m-bromophenylalanine" EXACT RESID-alternate []
synonym: "meta-bromophenylalanine" EXACT RESID-alternate []
xref: DiffAvg: "78.90"
xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0"
xref: DiffMono: "77.910512"
xref: Formula: "Br 1 C 9 H 8 N 1 O 1"
xref: MassAvg: "226.07"
xref: MassMono: "224.978926"
xref: Origin: "F"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00972 ! monobrominated L-phenylalanine

[Term]
id: MOD:00185
name: L-4'-bromophenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to L-4'-bromophenylalanine." [PubMed:2076468, PubMed:9033387, RESID:AA0176]
synonym: "(2S)-2-amino-3-(4-bromophenyl)propanoic acid" EXACT RESID-systematic []
synonym: "4'BrPhe" EXACT PSI-MOD-label []
synonym: "bromination" RELATED Unimod-description []
synonym: "Bromo" RELATED PSI-MS-label []
synonym: "L-4'-bromophenylalanine" EXACT RESID-name []
synonym: "p-bromophenylalanine" EXACT RESID-alternate []
synonym: "para-bromophenylalanine" EXACT RESID-alternate []
xref: DiffAvg: "78.90"
xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0"
xref: DiffMono: "77.910512"
xref: Formula: "Br 1 C 9 H 8 N 1 O 1"
xref: MassAvg: "226.07"
xref: MassMono: "224.978926"
xref: Origin: "F"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00972 ! monobrominated L-phenylalanine

[Term]
id: MOD:00186
name: 3,3',5-triiodo-L-thyronine
def: "A protein modification that effectively substitutes an L-tyrosine residue with 3,3',5-triiodo-L-thyronine." [ChEBI:18258, DeltaMass:0, RESID:AA0177, Unimod:397]
comment: From DeltaMass: Average Mass: 470.
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid" EXACT RESID-systematic []
synonym: "3',3'',5'-triiodo-L-thyronine" EXACT RESID-name []
synonym: "3,3',5-triiodo-L-thyronine" EXACT RESID-alternate []
synonym: "3,5,3'-triiodo-L-thyronine" EXACT RESID-alternate []
synonym: "3,5,3'-Triiodothyronine (from Tyrosine)" EXACT DeltaMass-label []
synonym: "4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine" EXACT RESID-alternate []
synonym: "I3Thy" EXACT PSI-MOD-label []
synonym: "liothyronine" EXACT RESID-alternate []
synonym: "MOD_RES Triiodothyronine" EXACT UniProt-feature []
synonym: "O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine" EXACT RESID-alternate []
synonym: "T3" EXACT RESID-alternate []
synonym: "triiodo" RELATED Unimod-description []
synonym: "Triiodothyronine" RELATED PSI-MS-label []
xref: DiffAvg: "469.79"
xref: DiffFormula: "C 6 H 1 I 3 N 0 O 1"
xref: DiffMono: "469.716158"
xref: Formula: "C 15 H 10 I 3 N 1 O 3"
xref: MassAvg: "632.96"
xref: MassMono: "632.779486"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:397"
xref: uniprot.ptm:PTM-0295
is_a: MOD:00998 ! iodinated tyrosine

[Term]
id: MOD:00187
name: L-thyroxine
def: "A protein modification that effectively substitutes an L-tyrosine residue with L-thyroxine." [ChEBI:18332, PubMed:6704086, RESID:AA0178, Unimod:398]
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid" EXACT RESID-systematic []
synonym: "3',3'',5',5''-tetraiodo-L-thyronine" EXACT RESID-alternate []
synonym: "3,3',5,5'-tetraiodo-L-thyronine" EXACT RESID-alternate []
synonym: "3,5,3',5'-tetraiodo-L-thyronine" EXACT RESID-alternate []
synonym: "4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine" EXACT RESID-alternate []
synonym: "I4Thy" EXACT PSI-MOD-label []
synonym: "L-thyroxine" EXACT RESID-name []
synonym: "MOD_RES Thyroxine" EXACT UniProt-feature []
synonym: "O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine" EXACT RESID-alternate []
synonym: "T4" EXACT RESID-alternate []
synonym: "tetraiodo" RELATED Unimod-description []
synonym: "Thyroxine" RELATED PSI-MS-label []
xref: DiffAvg: "595.68"
xref: DiffFormula: "C 6 H 0 I 4 N 0 O 1"
xref: DiffMono: "595.612805"
xref: Formula: "C 15 H 9 I 4 N 1 O 3"
xref: MassAvg: "758.86"
xref: MassMono: "758.676134"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:398"
xref: uniprot.ptm:PTM-0294
is_a: MOD:00998 ! iodinated tyrosine

[Term]
id: MOD:00188
name: 6'-bromo-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to 6'-bromo-L-tryptophan." [PubMed:12118011, PubMed:9030520, PubMed:9033387, PubMed:9434739, RESID:AA0179, Unimod:340#W]
synonym: "(2S)-2-amino-3-(6-bromo-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "6'-bromo-L-tryptophan" EXACT RESID-name []
synonym: "6'-BrTrp" EXACT PSI-MOD-label []
synonym: "bromination" RELATED Unimod-description []
synonym: "Bromo" RELATED PSI-MS-label []
synonym: "MOD_RES 6'-bromotryptophan" EXACT UniProt-feature []
xref: DiffAvg: "78.90"
xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0"
xref: DiffMono: "77.910512"
xref: Formula: "Br 1 C 11 H 9 N 2 O 1"
xref: MassAvg: "265.11"
xref: MassMono: "263.989825"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:398"
xref: uniprot.ptm:PTM-0051
is_a: MOD:01068 ! halogenated tryptophan
is_a: MOD:01912 ! monobrominated residue

[Term]
id: MOD:00189
name: dehydroalanine (Ser)
def: "A protein modification that effectively converts an L-serine residue to dehydroalanine." [DeltaMass:0, OMSSA:140, OMSSA:164, OMSSA:96, PubMed:10220322, PubMed:1547888, PubMed:1815586, PubMed:2914619, PubMed:7947813, PubMed:8239649, RESID:AA0181#SER, Unimod:23#S]
subset: PSI-MOD-slim
synonym: "2,3-didehydroalanine" EXACT RESID-alternate []
synonym: "2-aminoacrylic acid" EXACT RESID-alternate []
synonym: "2-aminopropenoic acid" EXACT RESID-systematic []
synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate []
synonym: "anhydroserine" EXACT RESID-alternate []
synonym: "beta-elim-s" EXACT OMSSA-label []
synonym: "Dehydrated" RELATED PSI-MS-label []
synonym: "dehydro" EXACT OMSSA-label []
synonym: "dehydroalanine" EXACT RESID-name []
synonym: "Dha" EXACT RESID-alternate []
synonym: "Dha(Ser)" EXACT PSI-MOD-label []
synonym: "MOD_RES 2,3-didehydroalanine (Ser)" EXACT UniProt-feature []
synonym: "phospholosss" EXACT OMSSA-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 3 H 3 N 1 O 1"
xref: MassAvg: "69.06"
xref: MassMono: "69.021464"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:23"
xref: uniprot.ptm:PTM-0006
is_a: MOD:00416 ! phosphorylation of an hydroxyl amino acid with prompt loss of phosphate
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01168 ! dehydroalanine

[Term]
id: MOD:00190
name: dehydrobutyrine (Thr)
def: "A protein modification that effectively converts an L-threonine residue to dehydrobutyrine." [DeltaMass:0, OMSSA:141, OMSSA:164, OMSSA:97, PubMed:1547888, PubMed:3769923, RESID:AA0182, Unimod:23#T]
subset: PSI-MOD-slim
synonym: "(2Z)-2-aminobut-2-enoic acid" EXACT RESID-systematic []
synonym: "(Z)-2-amino-2-butenoic acid" EXACT RESID-alternate []
synonym: "(Z)-2-aminobutenoic acid" EXACT RESID-alternate []
synonym: "(Z)-dehydrobutyrine" EXACT RESID-name []
synonym: "2,3-didehydrobutyrine" EXACT RESID-alternate []
synonym: "3-methyldehydroalanine" EXACT RESID-alternate []
synonym: "alpha,beta-dehydroaminobutyric acid" EXACT RESID-alternate []
synonym: "anhydrothreonine" EXACT RESID-alternate []
synonym: "beta-elim-t" EXACT OMSSA-label []
synonym: "Dehydrated" RELATED PSI-MS-label []
synonym: "Dehydrated" RELATED Unimod-interim []
synonym: "Dehydration" RELATED Unimod-description []
synonym: "dehydro" EXACT OMSSA-label []
synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label []
synonym: "Dhb" EXACT RESID-alternate []
synonym: "Dhb(Thr)" EXACT PSI-MOD-label []
synonym: "methyl-dehydroalanine" EXACT RESID-alternate []
synonym: "MOD_RES 2,3-didehydrobutyrine" EXACT UniProt-feature []
synonym: "phospholosst" EXACT OMSSA-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 4 H 5 N 1 O 1"
xref: MassAvg: "83.09"
xref: MassMono: "83.037114"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:23"
xref: uniprot.ptm:PTM-0007
is_a: MOD:00416 ! phosphorylation of an hydroxyl amino acid with prompt loss of phosphate
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:01703 ! dehydrobutyrine

[Term]
id: MOD:00191
name: (Z)-2,3-didehydrotyrosine
def: "A protein modification that effectively converts L-tyrosine to (Z)-2,3-didehydrotyrosine." [PubMed:1347277, PubMed:9631087, RESID:AA0183]
comment: incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381
subset: PSI-MOD-slim
synonym: "(2Z)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid" EXACT RESID-systematic []
synonym: "(Z)-2,3-didehydrogenated tyrosine" EXACT PSI-MOD-alternate []
synonym: "(Z)-2,3-didehydrotyrosine" EXACT RESID-name []
synonym: "2-amino-3-oxo-butanoic_acid" RELATED Unimod-description []
synonym: "amino-(para-hydroxybenzylidenyl)acetic acid" EXACT RESID-alternate []
synonym: "cis-dehydrotyrosine" EXACT RESID-alternate []
synonym: "Didehydro" RELATED PSI-MS-label []
synonym: "green fluorescent protein chromophore" EXACT RESID-alternate []
synonym: "MOD_RES (Z)-2,3-didehydrotyrosine" EXACT UniProt-feature []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
synonym: "red fluorescent protein chromophore" EXACT RESID-alternate []
synonym: "Z-dHTyr" EXACT PSI-MOD-label []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 9 H 7 N 1 O 2"
xref: MassAvg: "161.16"
xref: MassMono: "161.047678"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0002
is_a: MOD:00706 ! dehydrogenated tyrosine

[Term]
id: MOD:00192
name: L-serine 5-imidazolinone glycine
def: "A protein modification that effectively crosslinks an L-serine residue and a glycine residue to form L-serine 5-imidazolinone glycine." [ChEBI:21393, PubMed:1347277, PubMed:9631087, RESID:AA0184]
comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365.
synonym: "(2-[(1R)-1-amino-2-hydroxyethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic []
synonym: "2-[1-amino-2-hydroxyethyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate []
synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate []
synonym: "CROSSLNK 5-imidazolinone (Ser-Gly)" EXACT UniProt-feature []
synonym: "green fluorescent protein chromophore" EXACT RESID-alternate []
synonym: "L-serine 5-imidazolinone glycine" EXACT RESID-name []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
synonym: "seryl-5-imidazolinone glycine" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 5 H 6 N 2 O 2"
xref: MassAvg: "126.11"
xref: MassMono: "126.042927"
xref: Origin: "G, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0049
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly)
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00193
name: L-3-oxoalanine (Cys)
def: "A protein modification that effectively converts an L-cysteine residue to L-oxoalanine." [DeltaMass:350, PubMed:14563551, PubMed:7628016, PubMed:8681943, PubMed:9478923, RESID:AA0185#CYS, Unimod:402#C]
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-oxopropanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-oxopropionic acid" EXACT RESID-alternate []
synonym: "C(alpha)-formylglycine" RELATED RESID-misnomer []
synonym: "L-3-oxoalanine" EXACT RESID-name []
synonym: "L-amino-malonic acid semialdehyde" EXACT RESID-alternate []
synonym: "L-aminomalonaldehydic acid" EXACT RESID-alternate []
synonym: "L-serinesemialdehyde" RELATED RESID-misnomer []
synonym: "MOD_RES 3-oxoalanine (Cys)" EXACT UniProt-feature []
synonym: "Oxala(Cys)" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.08"
xref: DiffFormula: "C 0 H -2 N 0 O 1 S -1"
xref: DiffMono: "-17.992806"
xref: Formula: "C 3 H 3 N 1 O 2"
xref: MassAvg: "85.06"
xref: MassMono: "85.016378"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:402"
xref: uniprot.ptm:PTM-0034
is_a: MOD:01169 ! L-3-oxoalanine

[Term]
id: MOD:00194
name: lactic acid
def: "A protein modification that effectively converts an L-serine residue to an amino-terminal lactic acid." [PubMed:7607233, RESID:AA0186, Unimod:403#S]
synonym: "(2R)-2-hydroxypropanoic acid" EXACT RESID-systematic []
synonym: "2-hydroxypropionic acid" EXACT RESID-alternate []
synonym: "alpha-hydroxypropionic acid" EXACT RESID-alternate []
synonym: "Lac(Ser)" EXACT PSI-MOD-label []
synonym: "lactic acid" EXACT RESID-name []
synonym: "lactic acid from N-term Ser" RELATED Unimod-description []
synonym: "MOD_RES Lactic acid" EXACT UniProt-feature []
synonym: "Ser->LacticAcid" RELATED PSI-MS-label []
xref: DiffAvg: "-15.02"
xref: DiffFormula: "C 0 H -1 N -1 O 0"
xref: DiffMono: "-15.010899"
xref: Formula: "C 3 H 5 O 2"
xref: MassAvg: "73.07"
xref: MassMono: "73.028954"
xref: Origin: "S"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:403"
xref: uniprot.ptm:PTM-0163
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00195
name: L-alanine 5-imidazolinone glycine
def: "A protein modification that effectively crosslinks an L-alanine residue and a glycine residue to form L-alanine 5-imidazolinone glycine." [PubMed:10220322, RESID:AA0187]
comment: Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365.
synonym: "(2-[(1S)-1-aminoethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic []
synonym: "2-[1-aminoethyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate []
synonym: "4-methylidene-imidazole-5-one active site" EXACT RESID-alternate []
synonym: "alanyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "CROSSLNK 5-imidazolinone (Ala-Gly)" EXACT UniProt-feature []
synonym: "L-alanine 5-imidazolinone glycine" EXACT RESID-name []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
synonym: "XLNK-1Ala-NGly(Imidazole)" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 5 H 6 N 2 O 1"
xref: MassAvg: "110.12"
xref: MassMono: "110.048013"
xref: Origin: "A, G"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0045
is_a: MOD:02040 ! crosslinked L-alanine residue
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly)
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00196
name: L-cysteine 5-imidazolinone glycine
def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form L-cysteine 5-imidazolinone glycine." [PubMed:1537807, RESID:AA0188]
comment: Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365.
synonym: "(2-[(1R)-1-amino-2-sulfanylethyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic []
synonym: "2-[1-amino-2-sulfanylethyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate []
synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate []
synonym: "CROSSLNK 5-imidazolinone (Cys-Gly)" EXACT UniProt-feature []
synonym: "cysteinyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "L-cysteine 5-imidazolinone glycine" EXACT RESID-name []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
synonym: "XLNK-1Cys-NGly(Imidazole)" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 5 H 6 N 2 O 1 S 1"
xref: MassAvg: "142.18"
xref: MassMono: "142.020084"
xref: Origin: "C, G"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0047
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly)
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00197
name: 2-imino-glutamine 5-imidazolinone glycine
def: "A protein modification that effectively crosslinks an L-glutamine residue and a glycine residue to form 2-imino-glutamine 5-imidazolinone glycine." [PubMed:11050230, PubMed:11209050, RESID:AA0189]
comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365.
synonym: "2,N-didehydroglutaminyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "2-(3-carbamoyl-1-imino-propyl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate []
synonym: "2-imino-glutamine 5-imidazolinone glycine" EXACT RESID-name []
synonym: "[2-(3-carbamoyl-1-imino-propyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate []
synonym: "[2-(4-amino-4-oxobutanimidoyl)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]acetic acid" EXACT RESID-systematic []
synonym: "CROSSLNK 2-iminomethyl-5-imidazolinone (Gln-Gly)" EXACT UniProt-feature []
synonym: "fluorescent protein FP583 chromophore" EXACT RESID-alternate []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
synonym: "red fluorescent protein chromophore" EXACT RESID-alternate []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1"
xref: DiffMono: "-20.026215"
xref: Formula: "C 7 H 7 N 3 O 2"
xref: MassAvg: "165.15"
xref: MassMono: "165.053826"
xref: Origin: "G, Q"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0013
is_a: MOD:02046 ! crosslinked L-glutamine residue
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly)

[Term]
id: MOD:00198
name: D-alanine (Ala)
def: "A protein modification that effectively converts an L-alanine residue to D-alanine." [PubMed:15023056, PubMed:7287302, PubMed:7961627, RESID:AA0191#ALA]
synonym: "(R)-2-aminopropanoic acid" EXACT RESID-systematic []
synonym: "D-Ala(Ala)" EXACT PSI-MOD-label []
synonym: "D-alanine" EXACT RESID-name []
synonym: "MOD_RES D-alanine (Ala)" EXACT UniProt-feature []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 3 H 5 N 1 O 1"
xref: MassAvg: "71.08"
xref: MassMono: "71.037114"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0112
is_a: MOD:00570 ! residues isobaric at 71.037114 Da
is_a: MOD:00862 ! D-alanine
is_a: MOD:00901 ! modified L-alanine residue

[Term]
id: MOD:00199
name: D-allo-isoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to a D-allo-isoleucine." [ChEBI:30007, PubMed:8223491, RESID:AA0192]
synonym: "(2R,3S)-2-amino-3-methylpentanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-methylpentanoic acid" EXACT RESID-alternate []
synonym: "3-methyl-norvaline" EXACT RESID-alternate []
synonym: "allo-D-isoleucine" EXACT RESID-alternate []
synonym: "alpha-amino-beta-methylvaleric acid" EXACT RESID-alternate []
synonym: "D-allo-isoleucine" EXACT RESID-name []
synonym: "D-Ile" EXACT PSI-MOD-label []
synonym: "D-threo-isoleucine" EXACT RESID-alternate []
synonym: "MOD_RES D-allo-isoleucine" EXACT UniProt-feature []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 6 H 11 N 1 O 1"
xref: MassAvg: "113.16"
xref: MassMono: "113.084064"
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0114
is_a: MOD:00306 ! residues isobaric at 113.084064 Da
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:00910 ! modified L-isoleucine residue

[Term]
id: MOD:00200
name: D-methionine
def: "A protein modification that effectively converts an L-methionine residue to D-methionine." [ChEBI:29984, PubMed:16033333, PubMed:2542051, RESID:AA0193]
synonym: "(2R)-2-amino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "2-amino-4-(methylthio)butanoic acid" EXACT RESID-alternate []
synonym: "2-amino-4-(methylthio)butyric acid" EXACT RESID-alternate []
synonym: "D-Met" EXACT PSI-MOD-label []
synonym: "D-methionine" EXACT RESID-name []
synonym: "MOD_RES D-methionine" EXACT UniProt-feature []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 5 H 9 N 1 O 1 S 1"
xref: MassAvg: "131.19"
xref: MassMono: "131.040485"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0120
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:00201
name: D-phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to D-phenylalanine." [ChEBI:29996, PubMed:1548227, PubMed:1644179, PubMed:2597281, RESID:AA0194]
synonym: "(R)-2-amino-3-phenylpropanoic acid" EXACT RESID-systematic []
synonym: "D-Phe" EXACT PSI-MOD-label []
synonym: "D-phenylalanine" EXACT RESID-name []
synonym: "MOD_RES D-phenylalanine" EXACT UniProt-feature []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 9 H 9 N 1 O 1"
xref: MassAvg: "147.18"
xref: MassMono: "147.068414"
xref: Origin: "F"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0121
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:00914 ! modified L-phenylalanine residue

[Term]
id: MOD:00202
name: D-serine (Ser)
def: "A protein modification that effectively converts an L-serine residue to D-serine." [PubMed:7973665, RESID:AA0195#SER]
synonym: "(R)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic []
synonym: "D-Ser(Ser)" EXACT PSI-MOD-label []
synonym: "D-serine" EXACT RESID-name []
synonym: "MOD_RES D-serine (Ser)" EXACT UniProt-feature []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 3 H 5 N 1 O 2"
xref: MassAvg: "87.08"
xref: MassMono: "87.032028"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0308
is_a: MOD:00891 ! D-serine
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00203
name: D-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to D-asparagine." [ChEBI:29957, PubMed:1859408, RESID:AA0196]
synonym: "(R)-2-amino-4-butanediamic acid" EXACT RESID-systematic []
synonym: "D-alpha-aminosuccinamic acid" EXACT RESID-alternate []
synonym: "D-Asn" EXACT PSI-MOD-label []
synonym: "D-asparagine" EXACT RESID-name []
synonym: "D-aspartic acid beta-amide" EXACT RESID-alternate []
synonym: "MOD_RES D-asparagine" EXACT UniProt-feature []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 4 H 6 N 2 O 2"
xref: MassAvg: "114.10"
xref: MassMono: "114.042927"
xref: Origin: "N"
xref: Source: "natural"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0115
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:00204
name: D-leucine
def: "A protein modification that effectively converts an L-leucine residue to D-leucine." [ChEBI:30005, PubMed:10461743, PubMed:12135762, PubMed:1358533, PubMed:1548227, RESID:AA0197]
synonym: "(2R)-2-amino-4-methylpentanoic acid" EXACT RESID-systematic []
synonym: "alpha-aminoisocaproic acid" EXACT RESID-alternate []
synonym: "D-Leu" EXACT PSI-MOD-label []
synonym: "D-leucine" EXACT RESID-name []
synonym: "MOD_RES D-leucine" EXACT UniProt-feature []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 6 H 11 N 1 O 1"
xref: MassAvg: "113.16"
xref: MassMono: "113.084064"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0119
is_a: MOD:00306 ! residues isobaric at 113.084064 Da
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:00911 ! modified L-leucine residue

[Term]
id: MOD:00205
name: D-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to D-tryptophan." [ChEBI:29955, PubMed:8910408, RESID:AA0198]
synonym: "(R)-2-amino-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "alpha-amino-beta-(3-indolyl)propionoic acid" EXACT RESID-alternate []
synonym: "D-Trp" EXACT PSI-MOD-label []
synonym: "D-tryptophan" EXACT RESID-name []
synonym: "MOD_RES D-tryptophan" EXACT UniProt-feature []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 11 H 10 N 2 O 1"
xref: MassAvg: "186.21"
xref: MassMono: "186.079313"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0123
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:00206
name: L-isoglutamyl-polyglycine
def: "A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine." [ChEBI:21343, PubMed:10074368, PubMed:16368691, PubMed:7992051, RESID:AA0201]
synonym: "gamma-glutamylpolyglycine" EXACT RESID-alternate []
synonym: "L-isoglutamyl-polyglycine" EXACT RESID-name []
synonym: "MOD_RES 5-glutamyl polyglycine" EXACT UniProt-feature []
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0394
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:00207
name: L-isoglutamyl-polyglutamic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid." [PubMed:10747868, PubMed:1680872, RESID:AA0202]
synonym: "gamma-glutamylpolyglutamic acid" EXACT RESID-alternate []
synonym: "L-isoglutamyl-polyglutamic acid" EXACT RESID-name []
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0395
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:00208
name: O4'-(phospho-5'-adenosine)-L-tyrosine
def: "A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphoadenosine through a phosphodiester bond to form O4'-(phospho-5'-adenosine)-L-tyrosine." [DeltaMass:0, PubMed:5543675, RESID:AA0203, Unimod:405#Y]
comment: From DeltaMass: Average Mass: 329.
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-[4-(5'-adenosine phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic []
synonym: "5'-adenylic-O-tyrosine" EXACT RESID-alternate []
synonym: "AMP binding site" RELATED Unimod-description []
synonym: "hydrogen 5'-adenylate tyrosine ester" EXACT RESID-alternate []
synonym: "MOD_RES O-AMP-tyrosine" EXACT UniProt-feature []
synonym: "O-5'-Adenosylation ( of Tyrosine)" EXACT DeltaMass-label []
synonym: "O4'-(phospho-5'-adenosine)-L-tyrosine" EXACT RESID-name []
synonym: "O4'-L-tyrosine 5'-adenosine phosphodiester" EXACT RESID-alternate []
synonym: "OAMPTyr" EXACT PSI-MOD-label []
synonym: "Phosphoadenosine" RELATED PSI-MS-label []
xref: DiffAvg: "329.21"
xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1"
xref: DiffMono: "329.052520"
xref: Formula: "C 19 H 21 N 6 O 8 P 1"
xref: MassAvg: "492.38"
xref: MassMono: "492.115848"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:405"
xref: uniprot.ptm:PTM-0332
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01165 ! adenylated residue

[Term]
id: MOD:00209
name: S-(2-aminovinyl)-D-cysteine (Cys-Ser)
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine." [PubMed:3181159, PubMed:3769923, RESID:AA0204#SER]
comment: Cross-link 2.
synonym: "(2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "(S,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate []
synonym: "CROSSLNK S-(2-aminovinyl)-D-cysteine (Ser-Cys)" EXACT UniProt-feature []
synonym: "S-(2-aminovinyl)-D-cysteine" EXACT RESID-name []
synonym: "XLNK-(D)SCys-VinAm" EXACT PSI-MOD-label []
xref: DiffAvg: "-64.04"
xref: DiffFormula: "C -1 H -4 N 0 O -3 S 0"
xref: DiffMono: "-64.016044"
xref: Formula: "C 5 H 7 N 2 O 1 S 1"
xref: MassAvg: "143.18"
xref: MassMono: "143.027909"
xref: Origin: "C, S"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0268
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01850 ! S-(2-aminovinyl)-D-cysteine

[Term]
id: MOD:00210
name: L-cysteine sulfenic acid
def: "A protein modification that effectively monooxygenates an L-cysteine residue to L-cysteine sulfenic acid." [DeltaMass:41, OMSSA:193, PubMed:10964927, PubMed:2501303, PubMed:8756456, PubMed:9214307, PubMed:9586994, PubMed:9587003, RESID:AA0205, Unimod:35#C]
comment: From DeltaMass: Average Mass: 16 Average Mass Change:16 Notes:Green et al. in J. B. C. 270, 18209-18211 (1995) quote Kim and Raines in Eur. J. Biochem. 224, 109-114 (1994). Kim and Raines using ESI-MS and sulfhydryl group titration found that bovine seminal ribonuclease contains a single oxidized sulfhydryl group, which cannot participate in a disulfide bond. This form of cysteine is called sulfenic acid (-SOH).
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-(hydroxysulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "(2R)-2-amino-3-(oxido-lambda(4)-sulfanyl)propanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "2-amino-2-carboxyethanesulfenic acid" EXACT RESID-alternate []
synonym: "2-amino-3-sulfinylpropanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "3-sulfenoalanine" EXACT RESID-alternate []
synonym: "ACT_SITE Cysteine sulfenic acid (-SOH) intermediate" EXACT UniProt-feature []
synonym: "CysOH" EXACT PSI-MOD-label []
synonym: "cysteine S-oxide [tautomer]" EXACT RESID-alternate []
synonym: "cysteine sulfoxide [tautomer]" EXACT RESID-alternate []
synonym: "cysteine sulphenic acid" EXACT RESID-alternate []
synonym: "L-cysteine sulfenic acid" EXACT RESID-name []
synonym: "mod193" EXACT OMSSA-label []
synonym: "MOD_RES Cysteine sulfenic acid (-SOH)" EXACT UniProt-feature []
synonym: "Oxidation" RELATED PSI-MS-label []
synonym: "S-hydroxycysteine" EXACT RESID-alternate []
synonym: "S-oxocysteine [tautomer]" EXACT RESID-alternate []
synonym: "S-oxycysteine [tautomer]" EXACT RESID-alternate []
synonym: "Sulfenic Acid (from Cysteine)" EXACT DeltaMass-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0"
xref: DiffMono: "15.994915"
xref: Formula: "C 3 H 5 N 1 O 2 S 1"
xref: MassAvg: "119.14"
xref: MassMono: "119.004099"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:35"
xref: uniprot.ptm:PTM-0107
is_a: MOD:00708 ! sulfur oxygenated L-cysteine
is_a: MOD:01854 ! sulfur monooxygenated residue

[Term]
id: MOD:00211
name: S-(glycyl)-L-cysteine (Cys-Gly)
def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine." [ChEBI:22050, PubMed:3306404, RESID:AA0206]
comment: Cross-link 2. For the modification of a C-terminal glycine by formation of a thioester bond with free L-cysteine see MOD:01777 [JSG].
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid" EXACT RESID-systematic []
synonym: "1-(cystein-S-yl)-glycinate" EXACT RESID-alternate []
synonym: "ACT_SITE Glycyl thioester intermediate" EXACT UniProt-feature []
synonym: "glycine cysteine thioester" EXACT RESID-alternate []
synonym: "S-(2-amino-1-oxoethyl)cysteine" EXACT RESID-alternate []
synonym: "S-(glycyl)-L-cysteine" EXACT RESID-name []
synonym: "XLNK-SCys-1Gly" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 5 H 7 N 2 O 2 S 1"
xref: MassAvg: "159.18"
xref: MassMono: "159.022823"
xref: Origin: "C, G"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0429
is_a: MOD:00395 ! thioester crosslinked residues
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00212
name: S-4-hydroxycinnamyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-4-hydroxycinnamyl-L-cysteine." [PubMed:7947803, PubMed:7981196, RESID:AA0207, Unimod:407]
synonym: "(2R)-2-amino-3-([(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "cinnamate cysteine thioester" EXACT RESID-alternate []
synonym: "Hydroxycinnamyl" RELATED PSI-MS-label []
synonym: "hydroxycinnamyl" RELATED Unimod-description []
synonym: "MOD_RES S-(4-hydroxycinnamyl)cysteine" EXACT UniProt-feature []
synonym: "S-4-hydroxycinnamyl-L-cysteine" EXACT RESID-name []
synonym: "S-para-coumaryl-L-cysteine" EXACT RESID-alternate []
xref: DiffAvg: "146.14"
xref: DiffFormula: "C 9 H 6 N 0 O 2 S 0"
xref: DiffMono: "146.036779"
xref: Formula: "C 12 H 11 N 1 O 3 S 1"
xref: MassAvg: "249.28"
xref: MassMono: "249.045964"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:407"
xref: uniprot.ptm:PTM-0414
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00213
name: chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
def: "A protein modification that effectively cross-links an L-serine residue to the polymer chondroitin sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:1794445, PubMed:1898736, PubMed:3472204, RESID:AA0208]
synonym: "chondroitin 4-sulfate (chondroitin sulfate A)" EXACT RESID-alternate []
synonym: "chondroitin 6-sulfate (chondroitin sulfate C)" EXACT RESID-alternate []
synonym: "chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT RESID-name []
synonym: "poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine; poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-6-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine" EXACT RESID-systematic []
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00002 ! O-glycosyl-L-serine

[Term]
id: MOD:00214
name: dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
def: "A protein modification that effectively cross-links an L-serine residue to the polymer dermatan 4-sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:2914936, PubMed:3472204, RESID:AA0209]
synonym: "beta-heparin" EXACT RESID-alternate []
synonym: "chondroitin sulfate B" EXACT RESID-alternate []
synonym: "dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT RESID-name []
synonym: "poly[beta-1,4-L-idopyranuronosyl-alpha-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine" EXACT RESID-systematic []
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00002 ! O-glycosyl-L-serine

[Term]
id: MOD:00215
name: heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
def: "A protein modification that effectively cross-links an L-serine residue to the polymer heparan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:3472204, RESID:AA0210]
synonym: "heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT RESID-name []
synonym: "heparin" EXACT RESID-alternate []
synonym: "heparitin sulfate" EXACT RESID-alternate []
synonym: "poly[alpha-1,4-(2-sulfate D-glucopyranuronosyl)-beta-1,4-(2-sulfamino-2-deoxy-6-sulfate D-glucosyl)]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-serine" EXACT RESID-systematic []
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00002 ! O-glycosyl-L-serine

[Term]
id: MOD:00216
name: N6-formyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-formyl-L-lysine." [OMSSA:43, PubMed:15799070, RESID:AA0211, Unimod:122#K]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-(formylamino)hexanoic acid" EXACT RESID-systematic []
synonym: "epsilon-formyllysine" EXACT RESID-alternate []
synonym: "Formyl" RELATED PSI-MS-label []
synonym: "Formylation" RELATED Unimod-description []
synonym: "formylk" EXACT OMSSA-label []
synonym: "MOD_RES N6-formyllysine" EXACT UniProt-feature []
synonym: "N(zeta)-formyllysine" EXACT RESID-alternate []
synonym: "N6-formyl-L-lysine" EXACT RESID-name []
synonym: "N6-formylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "N6FoLys" EXACT PSI-MOD-label []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 H 0 N 0 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "C 7 H 12 N 2 O 2"
xref: MassAvg: "156.19"
xref: MassMono: "156.089878"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:122"
xref: uniprot.ptm:PTM-0192
is_a: MOD:00409 ! N-formylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:00217
name: O4-arabinosyl-L-hydroxyproline
def: "A protein modification that effectively converts an L-proline residue to O4-arabinosyl-L-hydroxyproline." [DeltaMass:0, PubMed:666730, PubMed:7852316, RESID:AA0212, Unimod:408]
comment: secondary to RESID:AA0030; From DeltaMass: Average Mass: 147.
subset: PSI-MOD-slim
synonym: "(2S,4R)-4-(beta-L-arabinofuranosyloxy)pyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "4-(beta-L-arabinofuranosyloxy)proline" EXACT RESID-alternate []
synonym: "4-Glycosyloxy- (pentosyl,C5) (of Proline)" EXACT DeltaMass-label []
synonym: "beta-arabinofuranosyl-4-hydroxyproline" EXACT RESID-alternate []
synonym: "Glycosyl" RELATED PSI-MS-label []
synonym: "glycosyl-L-hydroxyproline" RELATED Unimod-description []
synonym: "O4-arabinosyl-L-hydroxyproline" EXACT RESID-name []
synonym: "O4-glycosyl-hydroxyproline" EXACT RESID-alternate []
synonym: "OAra4HyPro" EXACT PSI-MOD-label []
xref: DiffAvg: "148.11"
xref: DiffFormula: "C 5 H 8 N 0 O 5"
xref: DiffMono: "148.037173"
xref: Formula: "C 10 H 15 N 1 O 6"
xref: MassAvg: "245.23"
xref: MassMono: "245.089937"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:408"
xref: uniprot.ptm:PTM-0545
is_a: MOD:00396 ! O-glycosylated residue
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:00218
name: O-(phospho-5'-RNA)-L-serine
def: "A protein modification that effectively crosslinks an L-serine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-serine." [PubMed:1705009, RESID:AA0213]
synonym: "(S)-2-amino-3-(5'-ribonucleic acid phosphonoxy)propanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES O-(5'-phospho-RNA)-serine" EXACT UniProt-feature []
synonym: "O-(phospho-5'-RNA)-L-serine" EXACT RESID-name []
synonym: "O3-(phospho-5'-RNA)-L-serine" EXACT RESID-alternate []
synonym: "O3-L-serine 5'-RNA phosphodiester" EXACT RESID-alternate []
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0227
is_a: MOD:00751 ! ribonucleic acid linked residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00219
name: L-citrulline
def: "A protein modification that effectively converts an L-arginine residue to L-citrulline." [DeltaMass:0, OMSSA:33, PubMed:2466844, RESID:AA0214, Unimod:7#R]
comment: This modification is not the result of deamidation, instead the guanidino group is replaced with an ureido group.
subset: PSI-MOD-slim
synonym: "(S)-2-amino-5-(carbamoylamino)pentanoic acid" EXACT RESID-systematic []
synonym: "2-amino-5-(aminocarbonyl)aminopentanoic acid" EXACT RESID-alternate []
synonym: "alpha-amino-delta-ureidovaleric acid" EXACT RESID-alternate []
synonym: "Cit" EXACT PSI-MOD-label []
synonym: "citrullinationr" EXACT OMSSA-label []
synonym: "Citrulline" EXACT DeltaMass-label []
synonym: "Deamidated" RELATED PSI-MS-label []
synonym: "Deamidated" RELATED Unimod-interim []
synonym: "Deamidation" RELATED Unimod-description []
synonym: "delta-ureidonorvaline" EXACT RESID-alternate []
synonym: "L-citrulline" EXACT RESID-name []
synonym: "MOD_RES Citrulline" EXACT UniProt-feature []
synonym: "N5-(aminocarbonyl)ornithine" EXACT RESID-alternate []
synonym: "N5-carbamoylornithine" EXACT RESID-alternate []
synonym: "N5-carbamylornithine" EXACT RESID-alternate []
xref: DiffAvg: "0.98"
xref: DiffFormula: "C 0 H -1 N -1 O 1"
xref: DiffMono: "0.984016"
xref: Formula: "C 6 H 11 N 3 O 2"
xref: MassAvg: "157.17"
xref: MassMono: "157.085127"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:7"
xref: uniprot.ptm:PTM-0092
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00220
name: 4-hydroxy-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to a 4-hydroxy-L-arginine." [PubMed:10966817, PubMed:7650037, RESID:AA0215]
synonym: "(2S,4Xi)-2-amino-5-[(diaminomethylidene)amino]-4-hydroxypentanoic acid" EXACT RESID-systematic []
synonym: "2-amino-5-(carbamimidamido)-4-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "2-amino-5-[(aminoiminomethyl)amino]-4-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "2-amino-5-guanidino-4-hydroxypentanoic acid" EXACT RESID-alternate []
synonym: "4-hydroxy-L-arginine" EXACT RESID-name []
synonym: "4-hydroxylated L-arginine" EXACT PSI-MOD-alternate []
synonym: "4HyArg" EXACT PSI-MOD-label []
synonym: "C(gamma)-hydroxyarginine" EXACT RESID-alternate []
synonym: "gamma-hydroxyarginine" EXACT RESID-alternate []
synonym: "MOD_RES 4-hydroxyarginine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 12 N 4 O 2"
xref: MassAvg: "172.19"
xref: MassMono: "172.096026"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0042
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:00682 ! hydroxylated arginine

[Term]
id: MOD:00221
name: N-(L-isoaspartyl)-L-cysteine
def: "A protein modification that effectively crosslinks L-aspartic acid and L-cysteine residues via an isopeptide bond to form N-(L-isoaspartyl)-L-cysteine." [PubMed:8286361, RESID:AA0216]
comment: Cross-link 2.
synonym: "(S)-2-amino-4-((R)-1-carboxy-2-sulfanylethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "2-(3-amino-3-carboxypropanoyl)amino-3-mercaptopropanoic acid" EXACT RESID-alternate []
synonym: "2-amino-N4-(1-carboxy-2-mercaptoethyl)butanediamic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Isoaspartyl cysteine isopeptide (Cys-Asn)" EXACT UniProt-feature []
synonym: "N-(L-isoaspartyl)-L-cysteine" EXACT RESID-name []
synonym: "N-beta-aspartylcysteine" EXACT RESID-alternate []
synonym: "N-isoaspartyl cysteine" EXACT RESID-alternate []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 7 H 9 N 2 O 3 S 1"
xref: MassAvg: "201.22"
xref: MassMono: "201.033388"
xref: Origin: "C, N"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0151
is_a: MOD:02042 ! crosslinked L-asparagine residue
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:00946 ! crosslinked residues with loss of ammonia
is_a: MOD:00688 ! isopeptide crosslinked residues

[Term]
id: MOD:00222
name: 2'-alpha-mannosyl-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to 2'-alpha-mannosyl-L-tryptophan." [PubMed:15279557, PubMed:7547911, PubMed:7947762, RESID:AA0217, Unimod:41#W]
synonym: "(2S)-2-amino-3-(2-beta-D-mannopyranosyl-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "2'-mannosyl-L-tryptophan" EXACT RESID-name []
synonym: "2'-tryptophan C-mannoside" EXACT RESID-alternate []
synonym: "C2'ManTrp" EXACT PSI-MOD-label []
synonym: "CARBOHYD C-linked (Man) tryptophan" EXACT UniProt-feature []
synonym: "Hex" RELATED PSI-MS-label []
synonym: "Hexose" RELATED Unimod-description []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 17 H 20 N 2 O 6"
xref: MassAvg: "348.36"
xref: MassMono: "348.132136"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:41"
xref: uniprot.ptm:PTM-0505
is_a: MOD:00421 ! C-glycosylated residue
is_a: MOD:00595 ! monomannosylated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:00223
name: N6-mureinyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-mureinyl-L-lysine." [PubMed:4261992, RESID:AA0218]
synonym: "MOD_RES N6-murein peptidoglycan lysine" EXACT UniProt-feature []
synonym: "N6-[(2R,6S)-2-(N-(N-mureinyl-(R)-alanyl)-(S)-glutamyl)amino-6-amino-6-carboxy-1-oxohex-1-yl]lysine" EXACT RESID-alternate []
synonym: "N6-mureinyl-L-lysine" EXACT RESID-name []
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0195
is_a: MOD:01159 ! peptidoglycanated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:00224
name: 1-chondroitin sulfate-L-aspartic acid ester
def: "A protein modification that effectively converts an L-aspartic acid residue to 1-chondroitin sulfate-L-aspartic acid ester" [PubMed:1898736, RESID:AA0219]
synonym: "1-aspartic acid ester with 6-chondroitin 4-sulfate" EXACT RESID-alternate []
synonym: "1-chondroitin sulfate-L-aspartic acid ester" EXACT RESID-name []
synonym: "MOD_RES Aspartate 1-(chondroitin 4-sulfate)-ester" EXACT UniProt-feature []
synonym: "poly[beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate D-galactosyl)]beta-1,4-D-glucopyranuronosyl-beta-1,3-(2-acetamido-2-deoxy-4-sulfate-6-(1-L-aspartyl)-D-galactose)" EXACT RESID-alternate []
synonym: "protein-glycosaminoglycan-protein cross-link" EXACT RESID-alternate []
xref: Origin: "D"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0334
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:00225
name: S-(6-FMN)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(6-FMN)-L-cysteine." [PubMed:10869173, PubMed:1551870, PubMed:620783, RESID:AA0220, Unimod:409#C]
subset: PSI-MOD-slim
synonym: "(R)-2-amino-3-[6-riboflavin 5'-dihydrogen phosphate]sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "6-[S-cysteinyl]flavin mononucleotide" EXACT RESID-alternate []
synonym: "6-[S-cysteinyl]FMN" EXACT RESID-alternate []
synonym: "flavin mononucleotide" RELATED Unimod-description []
synonym: "FMNH" RELATED PSI-MS-label []
synonym: "MOD_RES S-6-FMN cysteine" EXACT UniProt-feature []
synonym: "S-(6-FMN)-L-cysteine" EXACT RESID-name []
synonym: "S6FMNCys" EXACT PSI-MOD-label []
xref: DiffAvg: "454.33"
xref: DiffFormula: "C 17 H 19 N 4 O 9 P 1 S 0"
xref: DiffMono: "454.088965"
xref: Formula: "C 20 H 24 N 5 O 10 P 1 S 1"
xref: MassAvg: "557.47"
xref: MassMono: "557.098150"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:409"
xref: uniprot.ptm:PTM-0271
is_a: MOD:02084 ! 6-FMN modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00226
name: 1'-(8alpha-FAD)-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FAD)-L-histidine." [DeltaMass:0, PubMed:10585424, PubMed:1396672, PubMed:4339951, PubMed:9261083, RESID:AA0221, Unimod:50#H]
comment: From DeltaMass: Average Mass: 784
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-(1-[8alpha riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]imidazol-4-yl)propanoic acid" EXACT RESID-systematic []
synonym: "1'-(8alpha-FAD)-L-histidine" EXACT RESID-name []
synonym: "8alpha-(N(epsilon)-histidyl)FAD" EXACT RESID-alternate []
synonym: "8alpha-(N1'-histidyl)FAD" EXACT RESID-alternate []
synonym: "8alpha-N3-histidyl FAD" RELATED RESID-misnomer []
synonym: "FAD" RELATED PSI-MS-label []
synonym: "Flavin adenine dinucleotide" RELATED Unimod-description []
synonym: "MOD_RES Tele-8alpha-FAD histidine" EXACT UniProt-feature []
synonym: "N theta and N pi-(8alpha-Flavin) (on Histidine)" EXACT DeltaMass-label []
synonym: "N(tau)-(8alpha-FAD)-histidine" EXACT RESID-alternate []
synonym: "Nt8aFADHis" EXACT PSI-MOD-label []
synonym: "tele-(8alpha-FAD)-histidine" EXACT RESID-alternate []
xref: DiffAvg: "783.54"
xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2"
xref: DiffMono: "783.141485"
xref: Formula: "C 33 H 38 N 12 O 16 P 2"
xref: MassAvg: "920.68"
xref: MassMono: "920.200396"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:50"
xref: uniprot.ptm:PTM-0288
is_a: MOD:00895 ! FAD modified residue
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:00227
name: omega-N-phospho-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to omega-N-phospho-L-arginine." [PubMed:8300603, RESID:AA0222, Unimod:21#R]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-([amino(phosphonoamino)methylidene]amino)pentanoic acid" EXACT RESID-systematic []
synonym: "(2S)-2-amino-5-(N'-phosphonocarbamimidamido)pentanoic acid" EXACT RESID-alternate []
synonym: "alpha-amino-delta-phosphonoguanidinovaleric acid" EXACT RESID-alternate []
synonym: "MOD_RES Phosphoarginine" EXACT UniProt-feature []
synonym: "N(gamma)-phosphoarginine" EXACT RESID-alternate []
synonym: "N(omega)-phosphono-L-arginine" EXACT RESID-alternate []
synonym: "N5-[imino(phosphonoamino)methyl]-L-ornithine" EXACT RESID-alternate []
synonym: "omega-N-phospho-L-arginine" EXACT RESID-name []
synonym: "PArg" EXACT PSI-MOD-label []
synonym: "Phospho" RELATED PSI-MS-label []
synonym: "phosphoarginine" EXACT RESID-alternate []
synonym: "Phosphorylation" RELATED Unimod-description []
xref: DiffAvg: "79.98"
xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "C 6 H 13 N 4 O 4 P 1"
xref: MassAvg: "236.17"
xref: MassMono: "236.067442"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:21"
xref: uniprot.ptm:PTM-0250
is_a: MOD:00902 ! modified L-arginine residue
is_a: MOD:01456 ! N-phosphorylated residue

[Term]
id: MOD:00228
name: S-diphytanylglycerol diether-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-diphytanylglycerol diether-L-cysteine." [PubMed:7797461, PubMed:8195126, RESID:AA0223, Unimod:410]
comment: incidental to RESID:AA0043.
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-([(2S)-2,3-bis(3,7,11,15-tetramethylhexadecanyloxy)propyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "Archaeol" RELATED PSI-MS-label []
synonym: "LIPID S-archaeol cysteine" EXACT UniProt-feature []
synonym: "S-(diphytanylglyceryl)-L-cysteine" EXACT RESID-name []
synonym: "S-[2',3'-bis(phytanyloxy)propyl]cysteine" EXACT RESID-alternate []
synonym: "S-archaeol cysteine" EXACT RESID-alternate []
synonym: "S-diphytanylglycerol diether" RELATED Unimod-description []
synonym: "SPhyt2GlyceroCys" EXACT PSI-MOD-label []
xref: DiffAvg: "635.16"
xref: DiffFormula: "C 43 H 86 N 0 O 2 S 0"
xref: DiffMono: "634.662782"
xref: Formula: "C 46 H 91 N 1 O 3 S 1"
xref: MassAvg: "738.30"
xref: MassMono: "737.671967"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:410"
xref: uniprot.ptm:PTM-0273
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00229
name: alpha-1-microglobulin-Ig alpha complex chromophore
def: "A protein modification that effectively converts two L-cysteine residues to form alpha-1-microglobulin-Ig alpha complex chromophore." [PubMed:11058759, PubMed:11877257, PubMed:7506257, PubMed:7535251, RESID:AA0224]
comment: Cross-link 2.
synonym: "alpha-1-microglobulin-Ig alpha complex chromophore" EXACT RESID-name []
synonym: "BINDING Multimeric 3-hydroxykynurenine chromophore (covalent)" EXACT UniProt-feature []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 6 H 8 N 2 O 2 S 2"
xref: MassAvg: "204.26"
xref: MassMono: "204.002720"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02044 ! crosslinked L-cysteine residue

[Term]
id: MOD:00230
name: bis-L-cysteinyl bis-L-histidino diiron disulfide
def: "A protein modification that effectively converts two L-cysteine residues, two L-histidine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bis-L-histidino diiron disulfide." [PubMed:2765515, PubMed:9651245, RESID:AA0225]
comment: Cross-link 4.
synonym: "bis-L-cysteinyl bis-L-histidino diiron disulfide" EXACT RESID-name []
synonym: "di-mu-sulfido(bis-S-cysteinyliron)(bis-N3'-histidinoiron)" EXACT RESID-systematic []
synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature []
synonym: "METAL Iron-sulfur (2Fe-2S); via pros nitrogen" EXACT UniProt-feature []
synonym: "Rieske iron-sulfur cofactor" EXACT RESID-alternate []
xref: DiffAvg: "171.78"
xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2"
xref: DiffMono: "171.783814"
xref: FormalCharge: "2-"
xref: Formula: "C 18 Fe 2 H 20 N 8 O 4 S 4"
xref: MassAvg: "652.34"
xref: MassMono: "651.920007"
xref: Origin: "C, C, H, H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00231
name: hexakis-L-cysteinyl hexairon hexasulfide
def: "A protein modification that effectively converts six L-cysteine residues and a six-iron six-sulfur cluster to hexakis-L-cysteinyl hexairon hexasulfide." [PubMed:1311311, PubMed:1318833, RESID:AA0226]
comment: Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "hexa-mu3-sulfido-hexakis(cysteinato-kappaS)-hexairon" EXACT RESID-systematic []
synonym: "hexa-mu3-sulfido-hexakis(S-cysteinyliron)" EXACT RESID-alternate []
synonym: "hexakis-L-cysteinyl hexairon hexasulfide" EXACT RESID-name []
synonym: "prismane iron-sulfur cofactor" EXACT RESID-alternate []
xref: DiffAvg: "521.38"
xref: DiffFormula: "C 0 Fe 6 H -6 N 0 O 0 S 6"
xref: DiffMono: "521.395649"
xref: FormalCharge: "1-"
xref: Formula: "C 18 Fe 6 H 24 N 6 O 6 S 12"
xref: MassAvg: "1140.22"
xref: MassMono: "1139.450758"
xref: Origin: "C, C, C, C, C, C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00232
name: N6-(phospho-5'-adenosine)-L-lysine
def: "A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form N6-(phospho-5'-adenosine)-L-lysine." [DeltaMass:316, PubMed:3882425, PubMed:4944632, RESID:AA0227, Unimod:405#K]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-(5'-adenosine phosphonamino)hexanoic acid" EXACT RESID-systematic []
synonym: "5'-adenylic-N6-L-lysine" EXACT RESID-alternate []
synonym: "ACT_SITE N6-AMP-lysine intermediate" EXACT UniProt-feature []
synonym: "AMP binding site" RELATED Unimod-description []
synonym: "AMP Lysyl" EXACT DeltaMass-label []
synonym: "epsilon-5'-adenylic-L-lysine" EXACT RESID-alternate []
synonym: "L-lysine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate []
synonym: "N(zeta)-5'-adenylic-L-lysine" EXACT RESID-alternate []
synonym: "N6-(phospho-5'-adenosine)-L-lysine" EXACT RESID-name []
synonym: "N6-L-lysine 5'-adenosine phosphoramidester" EXACT RESID-alternate []
synonym: "N6AMPLys" EXACT PSI-MOD-label []
synonym: "Phosphoadenosine" RELATED PSI-MS-label []
xref: DiffAvg: "329.21"
xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1"
xref: DiffMono: "329.052520"
xref: Formula: "C 16 H 24 N 7 O 7 P 1"
xref: MassAvg: "457.38"
xref: MassMono: "457.147483"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:405"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01165 ! adenylated residue

[Term]
id: MOD:00233
name: N6-(phospho-5'-guanosine)-L-lysine
def: "A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoguanosine through a phosphoramide ester bond to form N6-(phospho-5'-guanosine)-L-lysine." [DeltaMass:304, PubMed:6092377, PubMed:6264433, RESID:AA0228, Unimod:413#K]
comment: From DeltaMass: Average Mass: 345 Formula:C10H12O5N7P1 Monoisotopic Mass Change:345.047 Average Mass Change:345.209 References:PE Sciex
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-(5'-guanosine phosphonamino)hexanoic acid" EXACT RESID-systematic []
synonym: "5'-guanylic-N6-L-lysine" EXACT RESID-alternate []
synonym: "5'phos Guanosyl" EXACT DeltaMass-label []
synonym: "ACT_SITE N6-GMP-lysine intermediate" EXACT UniProt-feature []
synonym: "epsilon-5'-guanylic-L-lysine" EXACT RESID-alternate []
synonym: "L-lysine monoanhydride with 5'-guanylic acid" EXACT RESID-alternate []
synonym: "lysine guanosine-5'-monophosphate" EXACT RESID-alternate []
synonym: "N(zeta)-5'-guanylic-lysine" EXACT RESID-alternate []
synonym: "N6-(5'-guanylyl)-lysine" EXACT RESID-alternate []
synonym: "N6-(phospho-5'-guanosine)-L-lysine" EXACT RESID-name []
synonym: "N6-L-lysine 5'-guanosine phosphoramidester" EXACT RESID-alternate []
synonym: "N6GMPLys" EXACT PSI-MOD-label []
synonym: "phospho-guanosine" RELATED Unimod-description []
synonym: "Phosphoguanosine" RELATED PSI-MS-label []
xref: DiffAvg: "345.21"
xref: DiffFormula: "C 10 H 12 N 5 O 7 P 1"
xref: DiffMono: "345.047434"
xref: Formula: "C 16 H 24 N 7 O 8 P 1"
xref: MassAvg: "473.38"
xref: MassMono: "473.142397"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:413"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01163 ! guanylated residue

[Term]
id: MOD:00234
name: L-cysteine glutathione disulfide
def: "A protein modification that effectively converts an L-cysteine residue to S-glutathionyl-L-cysteine." [ChEBI:21264, DeltaMass:0, OMSSA:51, PubMed:3083866, PubMed:8344916, RESID:AA0229, Unimod:55]
comment: From DeltaMass: Average Mass: 305
comment: Glutamyl-transpeptidase cleaves glutathione into cysteinylglycine (Cys-Gly) and a Glu residue. [PubMed: 28537416]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-((2S)-2-((4R)-4-amino-4-carboxyl-1-oxobutyl)amino-3-(carboxylmethyl)amino-3-oxo-propyl)dithio-propanoic acid" EXACT RESID-systematic []
synonym: "cysteinyl glutathione" EXACT RESID-alternate []
synonym: "Glutathionation" EXACT DeltaMass-label []
synonym: "Glutathione" RELATED PSI-MS-label []
synonym: "glutathione disulfide" RELATED Unimod-description []
synonym: "glutathionec" EXACT OMSSA-label []
synonym: "L-cysteine glutathione disulfide" EXACT RESID-name []
synonym: "L-gamma-glutamyl-L-cysteinyl-glycine (2-1')-disulfide with L-cysteine" EXACT RESID-alternate []
synonym: "MOD_RES S-glutathionyl cysteine" EXACT UniProt-feature []
synonym: "N-(N-gamma-glutamyl-cystinyl)-glycine" EXACT RESID-alternate []
synonym: "SGltCys" EXACT PSI-MOD-label []
xref: DiffAvg: "305.30"
xref: DiffFormula: "C 10 H 15 N 3 O 6 S 1"
xref: DiffMono: "305.068156"
xref: Formula: "C 13 H 20 N 4 O 7 S 2"
xref: MassAvg: "408.44"
xref: MassMono: "408.077341"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:55"
xref: uniprot.ptm:PTM-0311
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01862 ! disulfide conjugated residue
relationship: contains MOD:02026 ! S-(cysteinyl-glycyl)-L-cysteine

[Term]
id: MOD:00235
name: S-nitrosyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-nitrosyl-L-cysteine." [PubMed:10442087, PubMed:11562475, PubMed:15688001, PubMed:8626764, PubMed:8637569, RESID:AA0230, Unimod:275]
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-nitrososulfanyl-propanoic acid" EXACT RESID-systematic []
synonym: "L-cysteine nitrite ester" EXACT RESID-alternate []
synonym: "MOD_RES S-nitrosocysteine" EXACT UniProt-feature []
synonym: "Nitrosyl" RELATED PSI-MS-label []
synonym: "S-nitrosocysteine" EXACT RESID-alternate []
synonym: "S-nitrosyl-L-cysteine" EXACT RESID-name []
synonym: "S-nitrosylation" RELATED Unimod-description []
synonym: "SNOCys" EXACT PSI-MOD-label []
xref: DiffAvg: "29.00"
xref: DiffFormula: "C 0 H -1 N 1 O 1 S 0"
xref: DiffMono: "28.990164"
xref: Formula: "C 3 H 4 N 2 O 2 S 1"
xref: MassAvg: "132.14"
xref: MassMono: "131.999348"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:275"
xref: uniprot.ptm:PTM-0280
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:02077 ! nitrosylated residue

[Term]
id: MOD:00236
name: N4-(ADP-ribosyl)-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to N4-(ADP-ribosyl)-L-asparagine." [PubMed:15842200, PubMed:2498316, RESID:AA0231, Unimod:213#N]
synonym: "(S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "ADP Ribose addition" RELATED Unimod-description []
synonym: "ADP-Ribosyl" RELATED PSI-MS-label []
synonym: "MOD_RES ADP-ribosylasparagine" EXACT UniProt-feature []
synonym: "N4-(ADP-ribosyl)-L-asparagine" EXACT RESID-name []
synonym: "N4-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-asparagine" EXACT RESID-alternate []
synonym: "N4-alpha-D-ribofuranosyl-L-asparagine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate []
xref: DiffAvg: "541.30"
xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2"
xref: DiffMono: "541.061109"
xref: Formula: "C 19 H 27 N 7 O 15 P 2"
xref: MassAvg: "655.41"
xref: MassMono: "655.104036"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:213"
xref: uniprot.ptm:PTM-0054
is_a: MOD:00752 ! monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:00237
name: L-beta-methylthioaspartic acid
def: "A protein modification that effectively converts an L-aspartic acid residue to L-beta-methylthioaspartic acid." [DeltaMass:61, OMSSA:13, OMSSA:26, PubMed:15473684, PubMed:8844851, RESID:AA0232, Unimod:39#D, ChEBI:73599]
subset: PSI-MOD-slim
synonym: "(2R,3Xi)-2-amino-3-(methylsulfanyl)butanedioic acid" EXACT RESID-systematic []
synonym: "3-(methylthio)-L-aspartic acid" EXACT RESID-name []
synonym: "3-carboxy-S-methyl-cysteine" EXACT RESID-alternate []
synonym: "3-methylthio-aspartic acid" EXACT RESID-alternate []
synonym: "3MeSAsp" EXACT PSI-MOD-label []
synonym: "beta-Methylthio-aspartic acid" EXACT DeltaMass-label []
synonym: "beta-methylthio-aspartic acid" EXACT RESID-alternate []
synonym: "Beta-methylthiolation" RELATED Unimod-description []
synonym: "bmethylthiold" EXACT OMSSA-label []
synonym: "Methylthio" RELATED Unimod-interim []
synonym: "methythiold" EXACT OMSSA-label []
synonym: "MOD_RES 3-methylthioaspartic acid" EXACT UniProt-feature []
xref: DiffAvg: "46.09"
xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1"
xref: DiffMono: "45.987721"
xref: Formula: "C 5 H 7 N 1 O 3 S 1"
xref: MassAvg: "161.18"
xref: MassMono: "161.014664"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:39"
xref: uniprot.ptm:PTM-0032
is_a: MOD:00904 ! modified L-aspartic acid residue
is_a: MOD:01153 ! methylthiolated residue

[Term]
id: MOD:00238
name: 5'-(N6-L-lysine)-L-topaquinone
def: "A protein modification that effectively cross-links an L-lysine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 5'-(N6-L-lysine)-L-topaquinone." [PubMed:8688089, RESID:AA0233]
comment: Cross-link 2; secondary to RESID:AA0147.
synonym: "1-[(S)-5-amino-5-carboxypentyl]amino-2-[(S)-2-amino-2-carboxyethyl]-2,6-cyclohexadien-4,5-dione" EXACT RESID-systematic []
synonym: "2'-(L-lys-N6-yl)-L-4',5'-topaquinone" EXACT RESID-name []
synonym: "2'-(L-lysine)-L-tyrosyl-4',5'-quinone" EXACT RESID-alternate []
synonym: "CROSSLNK Lysine tyrosylquinone (Lys-Tyr)" EXACT UniProt-feature []
synonym: "CROSSLNK Lysine tyrosylquinone (Tyr-Lys)" EXACT UniProt-feature []
synonym: "LTQ" EXACT RESID-alternate []
synonym: "lysyl oxidase cofactor" EXACT RESID-alternate []
xref: DiffAvg: "11.97"
xref: DiffFormula: "C 0 H -4 N 0 O 1"
xref: DiffMono: "11.963614"
xref: Formula: "C 15 H 17 N 3 O 4"
xref: MassAvg: "303.32"
xref: MassMono: "303.121906"
xref: Origin: "K, Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0171
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:02058 ! crosslinked L-tyrosine residue

[Term]
id: MOD:00239
name: S-methyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-methyl-L-cysteine." [PubMed:10660523, PubMed:11875433, PubMed:1339288, RESID:AA0234, Unimod:34#C]
subset: PSI-MOD-slim
synonym: "(R)-2-amino-3-(methylsulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "ACT_SITE S-methylcysteine intermediate" EXACT UniProt-feature []
synonym: "L-3-(methylthio)alanine" EXACT RESID-alternate []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES S-methylcysteine" EXACT UniProt-feature []
synonym: "S-methyl-L-cysteine" EXACT RESID-name []
synonym: "S-methylated L-cysteine" EXACT PSI-MOD-alternate []
synonym: "SMeCys" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 4 H 7 N 1 O 1 S 1"
xref: MassAvg: "117.17"
xref: MassMono: "117.024835"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
xref: uniprot.ptm:PTM-0636
is_a: MOD:00654 ! S-methylated residue
is_a: MOD:01682 ! monomethylated L-cysteine

[Term]
id: MOD:00240
name: 4-hydroxy-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 4-hydroxy-L-lysine." [PubMed:4005040, RESID:AA0235, ChEBI:141495]
comment: This modification was not structurally confirmed. Later 5-hydroxy-L-lysine was found at a homologous position in the same protein from closely related species. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "(2S,4R)-2,6-diamino-4-hydroxyhexanoic acid" EXACT RESID-systematic []
synonym: "4-hydroxy-L-lysine" EXACT RESID-name []
synonym: "4-hydroxylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "4HyLys" EXACT PSI-MOD-label []
synonym: "alpha,epsilon-diamino-gamma-hydroxycaproic acid" EXACT RESID-alternate []
synonym: "L-threo-gamma-hydroxylysine" EXACT RESID-alternate []
synonym: "MOD_RES 4-hydroxylysine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 12 N 2 O 2"
xref: MassAvg: "144.17"
xref: MassMono: "144.089878"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0664
is_a: MOD:01047 ! monohydroxylated lysine

[Term]
id: MOD:00241
name: N4-hydroxymethyl-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to N4-hydroxymethyl-L-asparagine." [RESID:AA0236, Unimod:414]
comment: N4-methyl-L-asparagine, see MOD:0079, was found at a homologous position of the same protein in a closely related species. Since the peptide containing this modification was obtained by enzymatic cleavage, not cyanogen bromide cleavage, it could have experienced oxidation of the following methionine residue, leading to the erroneous attribution of a mass of 29 for the modification rather than 14. comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "(2S)-2-amino-4-[(hydroxymethyl)amino]-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "2-amino-N4-hydroxymethylbutanediamic acid" EXACT RESID-alternate []
synonym: "beta-hydroxymethylasparagine" EXACT RESID-alternate []
synonym: "Hydroxymethyl" RELATED PSI-MS-label []
synonym: "hydroxymethyl" RELATED Unimod-description []
synonym: "N(gamma)-hydroxymethylasparagine" EXACT RESID-alternate []
synonym: "N4-hydroxymethyl-L-asparagine" EXACT RESID-name []
synonym: "N4-hydroxymethylasparagine" EXACT RESID-alternate []
xref: DiffAvg: "30.03"
xref: DiffFormula: "C 1 H 2 N 0 O 1"
xref: DiffMono: "30.010565"
xref: Formula: "C 5 H 8 N 2 O 3"
xref: MassAvg: "144.13"
xref: MassMono: "144.053492"
xref: Origin: "N"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:414"
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:00242
name: O-(ADP-ribosyl)-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-(ADP-ribosyl)-L-serine." [PubMed:15842200, PubMed:3141412, RESID:AA0237, Unimod:213#S]
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-propanoic acid" EXACT RESID-systematic []
synonym: "ADP Ribose addition" RELATED Unimod-description []
synonym: "ADP-Ribosyl" RELATED PSI-MS-label []
synonym: "MOD_RES ADP-ribosylserine" EXACT UniProt-feature []
synonym: "O-(ADP-ribosyl)-L-serine" EXACT RESID-name []
synonym: "O3-(ADP-ribosyl)-L-serine" EXACT RESID-alternate []
synonym: "O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-serine" EXACT RESID-alternate []
synonym: "O3-alpha-D-ribofuranosyl-L-serine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate []
synonym: "OADPRibSer" EXACT PSI-MOD-label []
xref: DiffAvg: "541.30"
xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2"
xref: DiffMono: "541.061109"
xref: Formula: "C 18 H 26 N 6 O 15 P 2"
xref: MassAvg: "628.38"
xref: MassMono: "628.093137"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:213"
xref: uniprot.ptm:PTM-0056
is_a: MOD:00752 ! monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00243
name: L-cysteine oxazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid." [PubMed:8183941, PubMed:8895467, RESID:AA0238]
comment: Cross-link 2.
synonym: "2-(1-azanyl-2-sulfanylethyl)-4-oxazolecarboxylic acid" EXACT RESID-alternate []
synonym: "2-[(1R)-1-amino-2-sulfanylethyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Oxazole-4-carboxylic acid (Cys-Ser)" EXACT UniProt-feature []
synonym: "L-cysteine oxazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 6 H 6 N 2 O 2 S 1"
xref: MassAvg: "170.19"
xref: MassMono: "170.014998"
xref: Origin: "C, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0376
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser)
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:00244
name: L-cysteine oxazoline-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazoline-4-carboxylic acid." [PubMed:1880060, RESID:AA0239]
comment: Cross-link 2.
synonym: "(4S)-2-[(1R)-1-amino-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1-azanyl-2-sulfanylethyl]-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Oxazoline-4-carboxylic acid (Cys-Ser)" EXACT UniProt-feature []
synonym: "L-cysteine oxazoline-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 6 H 8 N 2 O 2 S 1"
xref: MassAvg: "172.20"
xref: MassMono: "172.030649"
xref: Origin: "C, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0381
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser)
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00245
name: glycine oxazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks a glycine residue and an L-serine residue to form glycine oxazole-4-carboxylic acid." [PubMed:8183941, PubMed:8895467, RESID:AA0240]
comment: Cross-link 2.
synonym: "2-aminomethyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-azanylmethyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Oxazole-4-carboxylic acid (Gly-Ser)" EXACT UniProt-feature []
synonym: "glycine oxazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1"
xref: DiffMono: "-20.026215"
xref: Formula: "C 5 H 4 N 2 O 2"
xref: MassAvg: "124.10"
xref: MassMono: "124.027277"
xref: Origin: "G, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0377
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser)
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:00246
name: glycine thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form glycine thiazole-4-carboxylic acid." [ChEBI:21276, PubMed:8183941, PubMed:8895467, RESID:AA0241]
comment: Cross-link 2.
synonym: "2-(aminomethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-(azanylmethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Thiazole-4-carboxylic acid (Gly-Cys)" EXACT UniProt-feature []
synonym: "glycine thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 5 H 4 N 2 O 1 S 1"
xref: MassAvg: "140.16"
xref: MassMono: "140.004434"
xref: Origin: "C, G"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0378
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:00247
name: L-serine thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-serine thiazole-4-carboxylic acid." [PubMed:8183941, PubMed:8895467, RESID:AA0242]
comment: Cross-link 2.
synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1-azanyl-2-hydroxyethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Thiazole-4-carboxylic acid (Ser-Cys)" EXACT UniProt-feature []
synonym: "L-serine thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 6 H 6 N 2 O 2 S 1"
xref: MassAvg: "170.19"
xref: MassMono: "170.014998"
xref: Origin: "C, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0363
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:00248
name: L-phenylalanine thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazole-4-carboxylic acid." [PubMed:1880060, RESID:AA0243]
comment: Cross-link 2.
synonym: "2-[(1S)-1-amino-2-phenylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1-azanyl-2-phenylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Thiazole-4-carboxylic acid (Phe-Cys)" EXACT UniProt-feature []
synonym: "L-phenylalanine thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 12 H 10 N 2 O 1 S 1"
xref: MassAvg: "230.29"
xref: MassMono: "230.051384"
xref: Origin: "C, F"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0375
is_a: MOD:02053 ! crosslinked L-phenylalanine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:00249
name: L-cysteine thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks two L-cysteine residues to form L-cysteine thiazole-4-carboxylic acid." [PubMed:1880060, RESID:AA0244]
comment: Cross-link 2.
synonym: "2-[(1S)-1-amino-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1-azanyl-2-sulfanylethyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Thiazole-4-carboxylic acid (Cys-Cys)" EXACT UniProt-feature []
synonym: "L-cysteine thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 6 H 6 N 2 O 1 S 2"
xref: MassAvg: "186.25"
xref: MassMono: "185.992155"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0360
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:00250
name: L-lysine thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to form L-lysine thiazole-4-carboxylic acid." [PubMed:1880060, RESID:AA0245]
comment: Cross-link 2. Lysine is now thought not to be encoded in the peptide sequence modified to produce GE2270. See RESID:AA0470. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "2-[(1S)-1,5-diaminopentyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1,5-bis(azanyl)pentyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "L-lysine thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 9 H 13 N 3 O 1 S 1"
xref: MassAvg: "211.28"
xref: MassMono: "211.077933"
xref: Origin: "C, K"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:00251
name: O-(phospho-5'-DNA)-L-serine
def: "A protein modification that effectively crosslinks an L-serine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-serine." [PubMed:7142163, PubMed:7265205, RESID:AA0246]
synonym: "(S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)propanoic acid" EXACT RESID-systematic []
synonym: "ACT_SITE O-(5'-phospho-DNA)-serine intermediate" EXACT UniProt-feature []
synonym: "MOD_RES O-(5'-phospho-DNA)-serine" EXACT UniProt-feature []
synonym: "O-(phospho-5'-DNA)-L-serine" EXACT RESID-name []
synonym: "O3-(phospho-5'-DNA)-L-serine" EXACT RESID-alternate []
synonym: "O3-L-serine 5'-DNA phosphodiester" EXACT RESID-alternate []
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0226
is_a: MOD:00750 ! deoxyribonucleic acid linked residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00252
name: keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine
def: "A protein modification that effectively cross-links an L-threonine residue to the polymer keratan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide." [PubMed:1417734, PubMed:3472204, RESID:AA0247]
synonym: "keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine" EXACT RESID-name []
synonym: "keratosulfate" EXACT RESID-alternate []
synonym: "poly[beta-1,4-(2-acetamido-2-deoxy-6-sulfate D-glucosyl)-beta-1,3-D-galactosyl]-beta-1,4-D-glucopyranuronosyl-beta-1,3-D-galactosyl-beta-1,3-D-galactosyl-beta-1,4-D-xylosyl-beta-1,3-L-threonine" EXACT RESID-systematic []
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00005 ! O-glycosyl-L-threonine

[Term]
id: MOD:00253
name: L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Sec)
def: "A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [PubMed:14235557, PubMed:2211698, PubMed:8052647, PubMed:9036855, RESID:AA0248#SEC, Unimod:415]
xref: DiffAvg: "1572.02"
xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 Se 0"
xref: DiffMono: "1572.985775"
xref: Formula: "C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1"
xref: MassAvg: "1722.07"
xref: MassMono: "1723.939410"
xref: Origin: "U"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:415"
is_a: MOD:00744 ! molybdenum pterin containing modification
is_a: MOD:01158 ! modified L-selenocysteine residue

[Term]
id: MOD:00254
name: O4'-(phospho-5'-RNA)-L-tyrosine
def: "A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-tyrosine." [PubMed:1702164, PubMed:209034, PubMed:217003, PubMed:6264310, RESID:AA0249]
synonym: "(S)-2-amino-3-[4-(5'-ribonucleic acid phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES O-(5'-phospho-RNA)-tyrosine" EXACT UniProt-feature []
synonym: "O4'-(phospho-5'-RNA)-L-tyrosine" EXACT RESID-name []
synonym: "O4'-L-tyrosine 5'-RNA phosphodiester" EXACT RESID-alternate []
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0229
is_a: MOD:00751 ! ribonucleic acid linked residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00255
name: 3-(3'-L-histidyl)-L-tyrosine
def: "A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3-(3'-L-histidyl)-L-tyrosine." [PubMed:9144772, RESID:AA0250]
comment: Cross-link 2.
synonym: "(2S,3R)-2-amino-3-(5-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "3-(3'-L-histidyl)-L-tyrosine" EXACT RESID-name []
synonym: "3-(N3'-histidyl)tyrosine" EXACT RESID-alternate []
synonym: "3-(pi-histidyl)tyrosine" EXACT RESID-alternate []
synonym: "3-(pros-histidyl)tyrosine" EXACT RESID-alternate []
synonym: "beta-(N(delta)-histidyl)tyrosine" EXACT RESID-alternate []
synonym: "beta-(N3'-histidyl)tyrosine" EXACT RESID-alternate []
synonym: "CROSSLNK 3'-histidyl-3-tyrosine (His-Tyr)" EXACT UniProt-feature []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 15 H 14 N 4 O 3"
xref: MassAvg: "298.30"
xref: MassMono: "298.106590"
xref: Origin: "H, Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0027
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02048 ! crosslinked L-histidine residue
is_a: MOD:02058 ! crosslinked L-tyrosine residue

[Term]
id: MOD:00256
name: L-methionine sulfone
def: "A protein modification that dioxygenates an L-methionine residue to L-methionine sulfone." [DeltaMass:205, OMSSA:115, PubMed:12686488, PubMed:7786407, PubMed:7791219, PubMed:9252331, RESID:AA0251, Unimod:425#M]
comment: DeltaMass gives the formula C 5 H 9 N 3 O 1 S 1 with mass 163
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-4-(methylsulfonyl)butanoic acid" EXACT RESID-systematic []
synonym: "dihydroxy" RELATED Unimod-description []
synonym: "Dioxidation" RELATED PSI-MS-label []
synonym: "L-methionine S,S-dioxide" EXACT RESID-alternate []
synonym: "L-methionine sulfone" EXACT RESID-name []
synonym: "MethionylSulphone" EXACT DeltaMass-label []
synonym: "MetO2" EXACT PSI-MOD-label []
synonym: "MOD_RES Methionine sulfone" EXACT UniProt-feature []
synonym: "Oxidation of Methionine (to Sulphone)" EXACT DeltaMass-label []
synonym: "S,S-dioxymethionine" EXACT RESID-alternate []
synonym: "suphonem" EXACT OMSSA-label []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2 S 0"
xref: DiffMono: "31.989829"
xref: Formula: "C 5 H 9 N 1 O 3 S 1"
xref: MassAvg: "163.19"
xref: MassMono: "163.030314"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:425"
xref: uniprot.ptm:PTM-0175
is_a: MOD:00709 ! sulfur oxygenated L-methionine
is_a: MOD:01855 ! sulfur dioxygenated residue


[Term]
id: MOD:00257
name: dipyrrolylmethanemethyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to dipyrrolylmethanemethyl-L-cysteine." [PubMed:3042456, PubMed:3196304, PubMed:3421931, PubMed:8727319, RESID:AA0252, Unimod:416]
synonym: "(2S)-3-[5-[4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methyl-4-(2-carboxy)ethyl-3-carboxymethyl-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid" EXACT RESID-systematic []
synonym: "3-[5-(3-acetic acid-4-propanoic acid-1-pyrrol-2-yl)methyl-3-acetic acid-4-propanoic acid-1-pyrrol-2-yl]methylthio-2-aminopropanoic acid" EXACT RESID-alternate []
synonym: "dipyrrole cofactor" EXACT RESID-alternate []
synonym: "Dipyrrolylmethanemethyl" RELATED PSI-MS-label []
synonym: "dipyrrolylmethanemethyl" RELATED Unimod-description []
synonym: "dipyrrolylmethanemethyl-L-cysteine" EXACT RESID-name []
synonym: "dipyrrolylmethyl-L-cysteine" EXACT RESID-alternate []
synonym: "dipyrromethane cofactor" EXACT RESID-alternate []
synonym: "MOD_RES S-(dipyrrolylmethanemethyl)cysteine" EXACT UniProt-feature []
synonym: "pyrromethane cofactor" EXACT RESID-alternate []
xref: DiffAvg: "418.40"
xref: DiffFormula: "C 20 H 22 N 2 O 8 S 0"
xref: DiffMono: "418.137616"
xref: Formula: "C 23 H 27 N 3 O 9 S 1"
xref: MassAvg: "521.54"
xref: MassMono: "521.146800"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:416"
xref: uniprot.ptm:PTM-0421
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00258
name: S-(2-aminovinyl)-3-methyl-D-cysteine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form S-(2-aminovinyl)-3-methyl-D-cysteine." [PubMed:9119018, RESID:AA0253]
comment: Cross-link 2.
synonym: "(2S,3S)-2-amino-3-[((Z)-2-aminoethenyl)sulfanyl]butanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-[(2-aminovinyl)sulfanyl]butanoic acid" EXACT RESID-alternate []
synonym: "CROSSLNK S-(2-aminovinyl)-3-methyl-D-cysteine (Thr-Cys)" EXACT UniProt-feature []
synonym: "decarboxylated methyllanthionine" EXACT RESID-alternate []
synonym: "S-(2-aminovinyl)-3-methyl-D-cysteine" EXACT RESID-name []
xref: DiffAvg: "-64.04"
xref: DiffFormula: "C -1 H -4 N 0 O -3 S 0"
xref: DiffMono: "-64.016044"
xref: Formula: "C 6 H 9 N 2 O 1 S 1"
xref: MassAvg: "157.21"
xref: MassMono: "157.043559"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0267
is_a: MOD:00687 ! thioether crosslinked residues
is_a: MOD:02056 ! crosslinked L-threonine residue

[Term]
id: MOD:00259
name: O4'-(phospho-5'-DNA)-L-tyrosine
def: "A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of DNA through a phosphodiester bond to form O4'-(phospho-5'-DNA)-L-tyrosine." [PubMed:1861973, PubMed:2940511, PubMed:3684578, RESID:AA0254]
synonym: "(S)-2-amino-3-[4-(5'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic []
synonym: "ACT_SITE O-(5'-phospho-DNA)-tyrosine intermediate" EXACT UniProt-feature []
synonym: "MOD_RES O-(5'-phospho-DNA)-tyrosine" EXACT UniProt-feature []
synonym: "O4'-(phospho-5'-DNA)-L-tyrosine" EXACT RESID-name []
synonym: "O4'-L-tyrosine 5'-DNA phosphodiester" EXACT RESID-alternate []
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0228
is_a: MOD:00750 ! deoxyribonucleic acid linked residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00260
name: O-(phospho-5'-DNA)-L-threonine
def: "A protein modification that effectively crosslinks an L-threonine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-threonine." [PubMed:3081736, RESID:AA0255]
synonym: "(S)-2-amino-3-(5'-deoxyribonucleic acid phosphonoxy)butanoic acid" EXACT RESID-systematic []
synonym: "O-(phospho-5'-DNA)-L-threonine" EXACT RESID-name []
synonym: "O3-(phospho-5'-DNA)-L-threonine" EXACT RESID-alternate []
synonym: "O3-L-threonine 5'-DNA phosphodiester" EXACT RESID-alternate []
xref: DiffAvg: "78.97"
xref: DiffFormula: "C 0 H 0 N 0 O 3 P 1"
xref: DiffMono: "78.958505"
xref: Formula: "C 4 H 7 N 1 O 5 P 1"
xref: MassAvg: "180.08"
xref: MassMono: "180.006184"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00750 ! deoxyribonucleic acid linked residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:00261
name: O4'-(phospho-5'-uridine)-L-tyrosine
def: "A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphouridine through a phosphodiester bond to form O4'-(phospho-5'-uridine)-L-tyrosine." [DeltaMass:0, PubMed:11467524, PubMed:2885322, RESID:AA0256, Unimod:417#Y]
comment: From DeltaMass: Average Mass: 306.
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-[4-(5'-uridine phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic []
synonym: "5'-uridylic-O-tyrosine" EXACT RESID-alternate []
synonym: "hydrogen 5'-uridylate tyrosine ester" EXACT RESID-alternate []
synonym: "MOD_RES O-UMP-tyrosine" EXACT UniProt-feature []
synonym: "O-Uridinylylation (of Tyrosine)" EXACT DeltaMass-label []
synonym: "O4'-(phospho-5'-uridine)-L-tyrosine" EXACT RESID-name []
synonym: "O4'-L-tyrosine 5'-uridine phosphodiester" EXACT RESID-alternate []
synonym: "OUMPTyr" EXACT PSI-MOD-label []
synonym: "PhosphoUridine" RELATED PSI-MS-label []
synonym: "uridine phosphodiester" RELATED Unimod-description []
xref: DiffAvg: "306.17"
xref: DiffFormula: "C 9 H 11 N 2 O 8 P 1"
xref: DiffMono: "306.025302"
xref: Formula: "C 18 H 20 N 3 O 10 P 1"
xref: MassAvg: "469.34"
xref: MassMono: "469.088630"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:417"
xref: uniprot.ptm:PTM-0333
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01166 ! uridylated residue

[Term]
id: MOD:00262
name: N-(L-glutamyl)-L-tyrosine
def: "A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and a free L-tyrosine." [ChEBI:21477, PubMed:6387372, PubMed:8093886, RESID:AA0257]
comment: Cross-link 2.
synonym: "(S,S)-2-(2-aminopentanedio-1-yl)amino-3-(4-hydoxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "L-glutamyl L-tyrosine" EXACT RESID-name []
synonym: "N-(L-glutamyl)-L-tyrosine" EXACT RESID-alternate []
synonym: "SITE Involved in polymerization" EXACT UniProt-feature []
xref: DiffAvg: "-17.01"
xref: DiffFormula: "C 0 H -1 N 0 O -1"
xref: DiffMono: "-17.002740"
xref: Formula: "C 14 H 16 N 2 O 5"
xref: MassAvg: "292.29"
xref: MassMono: "292.105922"
xref: Origin: "E, Y"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:02045 ! crosslinked L-glutamic acid residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00263
name: S-phycoviolobilin-L-cysteine
def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoviolobilin." [PubMed:2106585, PubMed:3208761, RESID:AA0258, Unimod:387]
synonym: "(4S)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-18-ethyl-4,5-dihydro-2,7,13,17-tetramethyl-(21H,22H,24H)-biladiene-bc-1,19-dione" EXACT RESID-systematic []
synonym: "BINDING Phycoviolobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature []
synonym: "cryptobiliviolin" EXACT RESID-alternate []
synonym: "cryptoviolin" EXACT RESID-alternate []
synonym: "cryptoviolobilin" EXACT RESID-alternate []
synonym: "PBV" EXACT RESID-alternate []
synonym: "Phycocyanobilin" RELATED PSI-MS-label []
synonym: "phycocyanobilin" RELATED Unimod-description []
synonym: "PVB" EXACT RESID-alternate []
synonym: "PXB" EXACT RESID-alternate []
synonym: "S-phycobiliviolin-L-cysteine" EXACT RESID-alternate []
synonym: "S-phycoviolobilin-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "586.69"
xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0"
xref: DiffMono: "586.279135"
xref: Formula: "C 36 H 43 N 5 O 7 S 1"
xref: MassAvg: "689.83"
xref: MassMono: "689.288320"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:387"
is_a: MOD:00700 ! tetrapyrrole modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00264
name: phycoerythrobilin-bis-L-cysteine
def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycoerythrobilin." [PubMed:3208761, PubMed:3838747, RESID:AA0259]
comment: Cross-link 2.
synonym: "(2S,3R,16R)-3,18-bis-[(R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-2,3,15,16-tetrahydrobilin-1,19(21H,22H,24H)-dione" EXACT RESID-systematic []
synonym: "3,18-bis-[1-((2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,3,15,16-tetrahydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-biladiene-ab-8,12-dipropanoic acid" EXACT RESID-alternate []
synonym: "BINDING Phycoerythrobilin chromophore (covalent; via 2 links)" EXACT UniProt-feature []
synonym: "PEB" EXACT RESID-alternate []
synonym: "phycoerythrobilin biscysteine adduct" EXACT RESID-alternate []
synonym: "phycoerythrobilin-bis-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "586.69"
xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0"
xref: DiffMono: "586.279135"
xref: Formula: "C 39 H 48 N 6 O 8 S 2"
xref: MassAvg: "792.97"
xref: MassMono: "792.297505"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00700 ! tetrapyrrole modified residue
is_a: MOD:02044 ! crosslinked L-cysteine residue

[Term]
id: MOD:00265
name: phycourobilin-bis-L-cysteine
def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycourobilin." [PubMed:3208761, PubMed:3838665, PubMed:3838747, PubMed:8876649, RESID:AA0260]
comment: Cross-link 2.
synonym: "3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-2,7,13,17-tetramethyl-1,19-dioxo-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-8,12-dipropanoic acid" EXACT RESID-alternate []
synonym: "3,18-bis(1-[(R)-2-amino-2-carboxyethyl]sulfanylethyl)-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydro-(21H,22H,24H)-bilene-b-1,19(4H,16H)-dione" EXACT RESID-systematic []
synonym: "BINDING Phycourobilin chromophore (covalent; via 2 links)" EXACT UniProt-feature []
synonym: "phycourobilin biscysteine adduct" EXACT RESID-alternate []
synonym: "phycourobilin-bis-L-cysteine" EXACT RESID-name []
synonym: "PUB" EXACT RESID-alternate []
xref: DiffAvg: "586.69"
xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0"
xref: DiffMono: "586.279135"
xref: Formula: "C 39 H 48 N 6 O 8 S 2"
xref: MassAvg: "792.97"
xref: MassMono: "792.297505"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00700 ! tetrapyrrole modified residue
is_a: MOD:02044 ! crosslinked L-cysteine residue

[Term]
id: MOD:00266
name: N-L-glutamyl-poly-L-glutamic acid
def: "A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and one or more free L-glutamic acid molecules to form N-(L-glutamyl)-poly-L-glutamic acid." [PubMed:2570347, PubMed:328274, RESID:AA0261]
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:00267
name: L-cysteine sulfinic acid
def: "A protein modification that effectively dioxygenates an L-cysteine residue to L-cysteine sulfinic acid." [ChEBI:16345, OMSSA:162, PubMed:12686488, PubMed:9252331, PubMed:9586994, RESID:AA0262, Unimod:425#C]
comment: "Hyun Ae Woo, et. al., Science 300 (5619), 653-656"
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-sulfinopropanoic acid" EXACT RESID-systematic []
synonym: "2-amino-2-carboxyethanesulfinic acid" EXACT RESID-alternate []
synonym: "2-amino-3-(dioxido-lambda(6)-sulfanyl)propanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "2-amino-3-sulfonylpropanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "3-sulfinoalanine" EXACT RESID-alternate []
synonym: "3-sulphinoalanine" EXACT RESID-alternate []
synonym: "CysO2H" EXACT PSI-MOD-label []
synonym: "cysteine sulphinic acid" EXACT RESID-alternate []
synonym: "cysteine-S,S-dioxide [tautomer]" EXACT RESID-alternate []
synonym: "dihydroxy" RELATED Unimod-description []
synonym: "Dioxidation" RELATED PSI-MS-label []
synonym: "L-cysteine sulfinic acid" EXACT RESID-name []
synonym: "MOD_RES Cysteine sulfinic acid (-SO2H)" EXACT UniProt-feature []
synonym: "S-cysteinesulfinic acid" EXACT RESID-alternate []
synonym: "S-sulfinocysteine" EXACT RESID-alternate []
synonym: "sulfinicacid" EXACT OMSSA-label []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2 S 0"
xref: DiffMono: "31.989829"
xref: Formula: "C 3 H 5 N 1 O 3 S 1"
xref: MassAvg: "135.14"
xref: MassMono: "134.999014"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:425"
xref: uniprot.ptm:PTM-0108
is_a: MOD:00708 ! sulfur oxygenated L-cysteine
is_a: MOD:01855 ! sulfur dioxygenated residue

[Term]
id: MOD:00268
name: L-3',4',5'-trihydroxyphenylalanine
def: "A protein modification that effectively converts an L-tyrosine residue to L-3',4',5'-trihydroxyphenylalanine." [DeltaMass:0, PubMed:12686488, PubMed:12771378, PubMed:8554314, PubMed:9252331, PubMed:9434739, RESID:AA0263, Unimod:425#Y, ChEBI:141811]
comment: From DeltaMass: Average Mass: 32
synonym: "(S)-2-amino-3-(3,4,5-trihydroxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "3,4,6-Trihydroxy-Phenylalanine (from Tyrosine) (TOPA)" EXACT DeltaMass-label []
synonym: "35Hy2Tyr" EXACT PSI-MOD-label []
synonym: "dihydroxy" RELATED Unimod-description []
synonym: "Dioxidation" RELATED PSI-MS-label []
synonym: "L-3',4',5'-trihydroxyphenylalanine" EXACT RESID-name []
synonym: "L-3,4,5-TOPA" EXACT RESID-alternate []
synonym: "MOD_RES 3',4',5'-trihydroxyphenylalanine" EXACT UniProt-feature []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 9 H 9 N 1 O 4"
xref: MassAvg: "195.17"
xref: MassMono: "195.053158"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:425"
xref: uniprot.ptm:PTM-0667
is_a: MOD:00428 ! dihydroxylated residue
is_a: MOD:00707 ! hydroxylated tyrosine

[Term]
id: MOD:00269
name: O-(sn-1-glycerophosphoryl)-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-(sn-1-glycerophosphoryl)-L-serine." [PubMed:8645220, RESID:AA0264, Unimod:419#S]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-[(2Xi)-2,3-dihydroxypropyl]phosphonoxypropanoic acid" EXACT RESID-systematic []
synonym: "alpha-glycerophosphoryl serine" EXACT RESID-alternate []
synonym: "Glycerophospho" RELATED PSI-MS-label []
synonym: "glycerophospho" RELATED Unimod-description []
synonym: "glycerophosphoserine" EXACT RESID-alternate []
synonym: "MOD_RES O-(sn-1-glycerophosphoryl)serine" EXACT UniProt-feature []
synonym: "O-(sn-1-glycerophosphoryl)-L-serine" EXACT RESID-name []
synonym: "O3-(sn-1-glycerophosphoryl)-L-serine" EXACT RESID-alternate []
synonym: "O3-2,3-dihydroxypropyl hydrogen phosphate-L-serine ester" EXACT RESID-alternate []
synonym: "O3-L-serine glyceryl-1-phosphodiester" EXACT RESID-alternate []
xref: DiffAvg: "154.06"
xref: DiffFormula: "C 3 H 7 N 0 O 5 P 1"
xref: DiffMono: "154.003110"
xref: Formula: "C 6 H 12 N 1 O 7 P 1"
xref: MassAvg: "241.14"
xref: MassMono: "241.035138"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:419"
xref: uniprot.ptm:PTM-0230
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00270
name: 1-thioglycine (internal)
def: "A protein modification that effectively converts a glycine residue to an internal 1-thioglycine." [PubMed:11463785, PubMed:9367957, RESID:AA0265#INT]
comment: This modification occurs naturally in two forms. At an interior peptide location it exists as aminoethanethionic acid (or aminoethanethioic O-acid). At the carboxyl-terminal it exists as aminoethanethiolic acid (or aminoethanethioic S-acid).
subset: PSI-MOD-slim
synonym: "1-thioglycine" EXACT RESID-name []
synonym: "2-amino-1-sulfanylethanone" EXACT RESID-alternate []
synonym: "aminoethanethioic acid" EXACT RESID-systematic []
synonym: "aminoethanethioic O-acid" EXACT RESID-alternate []
synonym: "aminoethanethionic acid" EXACT RESID-alternate []
synonym: "aminothioacetic acid" EXACT RESID-alternate []
synonym: "Carboxy->Thiocarboxy" RELATED PSI-MS-label []
synonym: "MOD_RES 1-thioglycine" EXACT UniProt-feature []
synonym: "S(O)Gly" EXACT PSI-MOD-label []
synonym: "thiocarboxylic acid" RELATED Unimod-description []
xref: DiffAvg: "16.06"
xref: DiffFormula: "C 0 H 0 N 0 O -1 S 1"
xref: DiffMono: "15.977156"
xref: Formula: "C 2 H 3 N 1 S 1"
xref: MassAvg: "73.11"
xref: MassMono: "72.998620"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0004
is_a: MOD:01625 ! 1-thioglycine

[Term]
id: MOD:00271
name: heme P460-bis-L-cysteine-L-tyrosine
def: "A protein modification that effectively results from forming an adduct between two cysteine residues, the C-3' of a tyrosine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:8325841, PubMed:9095195, RESID:AA0266]
comment: Cross-link 3.
synonym: "(10S,11S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-10-(2-hydroxy-5-[(S)-2-amino-2-carboxy]ethylphenyl)-3,8,13,17-tetramethyl-21H,23H-10,11-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic []
synonym: "BINDING Heme (covalent; via 3 links)" EXACT UniProt-feature []
synonym: "bis(S-cysteinyl)-(tyros-3'-yl)-heme" EXACT RESID-alternate []
synonym: "heme P460-bis-L-cysteine-L-tyrosine" EXACT RESID-name []
xref: DiffAvg: "614.48"
xref: DiffFormula: "C 34 Fe 1 H 30 N 4 O 4 S 0"
xref: DiffMono: "614.161643"
xref: Formula: "C 49 Fe 1 H 49 N 7 O 8 S 2"
xref: MassAvg: "983.94"
xref: MassMono: "983.243341"
xref: Origin: "C, C, Y"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00699 ! porphyrin modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02075 ! metal or metal cluster coordinated L-tyrosine residue

[Term]
id: MOD:00272
name: O-(phospho-5'-adenosine)-L-threonine
def: "A protein modification that effectively crosslinks an L-threonine residue and 5'-phosphoadenosine through a phosphodiester bond to form O-(phospho-5'-adenosine)-L-threonine." [PubMed:2989287, PubMed:8917428, RESID:AA0267, Unimod:405#T]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-(5'-adenosine phosphonoxy)butanoic acid" EXACT RESID-systematic []
synonym: "5'-adenylic-O3-L-threonine" EXACT RESID-alternate []
synonym: "ACT_SITE O-AMP-threonine intermediate" EXACT UniProt-feature []
synonym: "AMP binding site" RELATED Unimod-description []
synonym: "beta-5'-adenylic-L-threonine" EXACT RESID-alternate []
synonym: "L-threonine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate []
synonym: "MOD_RES O-AMP-threonine" EXACT UniProt-feature []
synonym: "O(gamma)-5'-adenylic-L-threonine" EXACT RESID-alternate []
synonym: "O-(phospho-5'-adenosine)-L-threonine" EXACT RESID-name []
synonym: "O3-(phospho-5'-adenosine)-L-threonine" EXACT RESID-alternate []
synonym: "O3-L-threonine 5'-adenosine phosphodiester" EXACT RESID-alternate []
synonym: "Phosphoadenosine" RELATED PSI-MS-label []
xref: DiffAvg: "329.21"
xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1"
xref: DiffMono: "329.052520"
xref: Formula: "C 14 H 19 N 6 O 8 P 1"
xref: MassAvg: "430.31"
xref: MassMono: "430.100198"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:405"
xref: uniprot.ptm:PTM-0393
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:01165 ! adenylated residue

[Term]
id: MOD:00273
name: tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide
def: "A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a four-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide." [PubMed:12764602, RESID:AA0268]
comment: Cross-link 7; secondary to RESID:AA0269.
synonym: "4Fe-2S-3O cluster" EXACT RESID-alternate []
synonym: "hybrid four iron cluster 2" EXACT RESID-alternate []
synonym: "METAL Iron-oxo-sulfur (4Fe-2O-2S)" EXACT UniProt-feature []
synonym: "METAL Iron-oxo-sulfur (4Fe-2O-2S); via persulfide group" EXACT UniProt-feature []
synonym: "METAL Iron-oxo-sulfur (4Fe-2O-2S); via tele nitrogen" EXACT UniProt-feature []
synonym: "mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-iron-3,4-bis-(S-cysteinyl iron)" EXACT RESID-systematic []
synonym: "prismane iron-sulfur cofactor" RELATED RESID-misnomer []
synonym: "tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide" EXACT RESID-name []
xref: DiffAvg: "360.50"
xref: DiffFormula: "C 0 Fe 4 H -7 N 0 O 3 S 3"
xref: DiffMono: "360.585932"
xref: Formula: "C 28 Fe 4 H 34 N 9 O 14 S 7"
xref: MassAvg: "1168.43"
xref: MassMono: "1167.766769"
xref: Origin: "C, C, C, C, E, E, H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02068 ! metal or metal cluster coordinated L-glutamic acid residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00274
name: L-cysteine persulfide
def: "A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a sulfanyl group, forming a disulfanyl group, and converting an L-cysteine residue to L-cysteine persulfide." [ChEBI:28839, PubMed:15096637, PubMed:4276457, PubMed:8161529, RESID:AA0269, Unimod:421]
subset: PSI-MOD-slim
synonym: "(R)-2-amino-3-disulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-disulfanylpropanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-hydrodisulfidopropanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-hydropersulfidopropanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-persulfhydrylpropanoic acid" EXACT RESID-alternate []
synonym: "3-(thiosulfeno)-alanine" EXACT RESID-alternate []
synonym: "3-disulfanylalanine" EXACT RESID-alternate []
synonym: "ACT_SITE Cysteine persulfide intermediate" EXACT UniProt-feature []
synonym: "L-cysteine persulfide" EXACT RESID-name []
synonym: "MOD_RES Cysteine persulfide" EXACT UniProt-feature []
synonym: "persulfide" RELATED Unimod-description []
synonym: "S-mercaptocysteine" EXACT RESID-alternate []
synonym: "S-sulfanylcysteine" EXACT RESID-alternate []
synonym: "Sulfide" RELATED PSI-MS-label []
synonym: "thiocysteine" EXACT RESID-alternate []
xref: DiffAvg: "32.06"
xref: DiffFormula: "C 0 H 0 N 0 O 0 S 1"
xref: DiffMono: "31.972071"
xref: Formula: "C 3 H 5 N 1 O 1 S 2"
xref: MassAvg: "135.20"
xref: MassMono: "134.981256"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:421"
xref: uniprot.ptm:PTM-0106
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01886 ! thiolated residue

[Term]
id: MOD:00275
name: 3'-(1'-L-histidyl)-L-tyrosine
def: "A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3'-(1'-L-histidyl)-L-tyrosine." [ChEBI:19837, PubMed:10338009, RESID:AA0270]
comment: Cross-link 2.
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-[1-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenyl)-1H-imidazol-4-yl]propanoic acid" EXACT RESID-systematic []
synonym: "3'-(1'-L-histidyl)-L-tyrosine" EXACT RESID-name []
synonym: "3'-(N(epsilon)-histidyl)tyrosine" EXACT RESID-alternate []
synonym: "3'-(N1'-histidyl)tyrosine" EXACT RESID-alternate []
synonym: "3'-(tau-histidyl)tyrosine" EXACT RESID-alternate []
synonym: "3'-(tele-histidyl)tyrosine" EXACT RESID-alternate []
synonym: "CROSSLNK 1'-histidyl-3'-tyrosine (His-Tyr)" EXACT UniProt-feature []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 15 H 14 N 4 O 3"
xref: MassAvg: "298.30"
xref: MassMono: "298.106590"
xref: Origin: "H, Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0003
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02048 ! crosslinked L-histidine residue
is_a: MOD:02058 ! crosslinked L-tyrosine residue

[Term]
id: MOD:00276
name: heme P460-bis-L-cysteine-L-lysine
def: "A protein modification that effectively results from forming an adduct between two cysteine residues, a lysine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:12709052, PubMed:9237682, RESID:AA0271]
comment: Cross-link 3.
synonym: "(19S,20S)-[7,12-bis((S)-1-[((R)-2-amino-2-carboxy)ethylsulfanyl]ethyl)-20-([(S)-5-amino-5-carboxypentyl]amino)-3,8,13,17-tetramethyl-21H,23H-19,20-dihydroporphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic []
synonym: "BINDING Heme (covalent; via 3 links)" EXACT UniProt-feature []
synonym: "bis(S-cysteinyl)-N6-lysino-heme" EXACT RESID-alternate []
synonym: "heme P460-bis-L-cysteine-L-lysine" EXACT RESID-name []
xref: DiffAvg: "614.48"
xref: DiffFormula: "C 34 Fe 1 H 30 N 4 O 4 S 0"
xref: DiffMono: "614.161643"
xref: Formula: "C 46 Fe 1 H 52 N 8 O 7 S 2"
xref: MassAvg: "948.94"
xref: MassMono: "948.274976"
xref: Origin: "C, C, K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00699 ! porphyrin modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02074 ! metal or metal cluster coordinated L-lysine residue

[Term]
id: MOD:00277
name: 5-methyl-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to 5-methyl-L-arginine." [PubMed:10660523, PubMed:11875433, PubMed:9367957, RESID:AA0272]
synonym: "(2S,5S)-2-amino-5-carbamimidamidohexanoic acid" EXACT RESID-systematic []
synonym: "2-amino-5-guanidinohexanoic acid" EXACT RESID-alternate []
synonym: "4-methylarginine" RELATED RESID-misnomer []
synonym: "5-methyl-L-arginine" EXACT RESID-name []
synonym: "5-methylated L-arginine" EXACT PSI-MOD-alternate []
synonym: "C5Me1Arg" EXACT PSI-MOD-label []
synonym: "delta-methylarginine" EXACT RESID-alternate []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES 5-methylarginine" EXACT UniProt-feature []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 14 N 4 O 1"
xref: MassAvg: "170.22"
xref: MassMono: "170.116761"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0050
is_a: MOD:00414 ! monomethylated L-arginine
is_a: MOD:00656 ! C-methylated residue

[Term]
id: MOD:00278
name: 2-methyl-L-glutamine
def: "A protein modification that effectively converts an L-glutamine residue to 2-methyl-L-glutamine." [PubMed:10660523, PubMed:11875433, PubMed:9367957, RESID:AA0273]
synonym: "(S)-2-amino-2-methylpentanediamic acid" EXACT RESID-systematic []
synonym: "2-methyl-L-glutamine" EXACT RESID-name []
synonym: "2-methylated L-glutamine" EXACT PSI-MOD-alternate []
synonym: "2-methylglutamine" EXACT RESID-alternate []
synonym: "alpha-methylglutamine" EXACT RESID-alternate []
synonym: "C2MeGln" EXACT PSI-MOD-label []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES 2-methylglutamine" EXACT UniProt-feature []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 6 H 10 N 2 O 2"
xref: MassAvg: "142.16"
xref: MassMono: "142.074228"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0016
is_a: MOD:00656 ! C-methylated residue
is_a: MOD:00722 ! monomethylated L-glutamine

[Term]
id: MOD:00279
name: N-pyruvic acid 2-iminyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to N-pyruvic acid 2-iminyl-L-cysteine." [PubMed:1388164, RESID:AA0274, Unimod:422#C]
subset: PSI-MOD-slim
synonym: "(R)-2-(1-carboxy-2-sulfanylethanimino)propanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES N-pyruvate 2-iminyl-cysteine" EXACT UniProt-feature []
synonym: "N-pyruvic acid 2-iminyl" RELATED Unimod-description []
synonym: "N-pyruvic acid 2-iminyl-L-cysteine" EXACT RESID-name []
synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label []
xref: DiffAvg: "70.05"
xref: DiffFormula: "C 3 H 2 N 0 O 2 S 0"
xref: DiffMono: "70.005479"
xref: Formula: "C 6 H 8 N 1 O 3 S 1"
xref: MassAvg: "174.19"
xref: MassMono: "174.022489"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:422"
xref: uniprot.ptm:PTM-0224
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01170 ! pyruvic acid iminylated residue

[Term]
id: MOD:00280
name: N-pyruvic acid 2-iminyl-L-valine
def: "A protein modification that effectively converts an L-valine residue to N-pyruvic acid 2-iminyl-L-valine." [PubMed:2071591, RESID:AA0275, Unimod:422#V]
subset: PSI-MOD-slim
synonym: "(S)-2-(1-carboxy-2-methylpropanimino)propanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES N-pyruvate 2-iminyl-valine" EXACT UniProt-feature []
synonym: "N-pyruvic acid 2-iminyl" RELATED Unimod-description []
synonym: "N-pyruvic acid 2-iminyl-L-valine" EXACT RESID-name []
synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label []
xref: DiffAvg: "70.05"
xref: DiffFormula: "C 3 H 2 N 0 O 2"
xref: DiffMono: "70.005479"
xref: Formula: "C 8 H 12 N 1 O 3"
xref: MassAvg: "170.19"
xref: MassMono: "170.081718"
xref: Origin: "V"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:422"
xref: uniprot.ptm:PTM-0225
is_a: MOD:00920 ! modified L-valine residue
is_a: MOD:01170 ! pyruvic acid iminylated residue

[Term]
id: MOD:00281
name: 3'-heme-L-histidine
def: "A protein modification that effectively results from forming an adduct between the pros nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:12119398, PubMed:12429096, PubMed:12486054, PubMed:9712585, RESID:AA0276]
synonym: "2-[1-(N3'-histidyl)ethyl]protoporphyrin IX" EXACT RESID-alternate []
synonym: "3'-heme-L-histidine" EXACT RESID-name []
synonym: "[7-ethenyl-12-((S)-1-[((R)-2-amino-2-carboxyethyl)-3H-imidazol-3-yl]ethyl)-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic []
synonym: "BINDING Heme (covalent; via pros nitrogen)" EXACT UniProt-feature []
synonym: "N(delta)-histidyl heme" EXACT RESID-alternate []
synonym: "N(pi)-histidyl heme" EXACT RESID-alternate []
synonym: "N3'-histidyl heme" EXACT RESID-alternate []
synonym: "pros-histidyl heme" EXACT RESID-alternate []
xref: DiffAvg: "616.50"
xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4"
xref: DiffMono: "616.177293"
xref: Formula: "C 40 Fe 1 H 39 N 7 O 5"
xref: MassAvg: "753.64"
xref: MassMono: "753.236205"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00699 ! porphyrin modified residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00282
name: S-selenyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-selenyl-L-cysteine." [PubMed:10430865, PubMed:10966817, PubMed:11827487, PubMed:12716131, PubMed:14594807, RESID:AA0277, Unimod:423#C]
synonym: "(R)-2-amino-3-(selanylsulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-hydroselenosulfidopropanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-hydroselenylsulfidopropanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-hydroselenylthiopropanoic acid" EXACT RESID-alternate []
synonym: "ACT_SITE S-selanylcysteine intermediate" EXACT UniProt-feature []
synonym: "cysteine perselenide" RELATED RESID-misnomer []
synonym: "Delta:Se(1)" RELATED PSI-MS-label []
synonym: "MOD_RES S-selenylcysteine" EXACT UniProt-feature []
synonym: "S-selanyl-L-cysteine" EXACT RESID-name []
synonym: "S-selanylcysteine" EXACT RESID-alternate []
synonym: "S-selenylcysteine" EXACT RESID-alternate []
synonym: "selenyl" RELATED Unimod-description []
xref: DiffAvg: "78.97"
xref: DiffFormula: "C 0 H 0 N 0 O 0 S 0 Se 1"
xref: DiffMono: "79.916521"
xref: Formula: "C 3 H 5 N 1 O 1 S 1 Se 1"
xref: MassAvg: "182.11"
xref: MassMono: "182.925706"
xref: Origin: "C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:423"
xref: uniprot.ptm:PTM-0282
is_a: MOD:00745 ! selenium containing residue
is_a: MOD:00778 ! residues isobaric at 182.9-183.0 Da
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00283
name: N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to an N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine." [PubMed:10550045, PubMed:11349130, RESID:AA0278]
synonym: "(alpha)- ([([(5S)-5-amino-5-carboxypentyl]amino)propyl][(methyl)amino])-(omega)-methyl poly[propane-1,3-diyl(methylimino)]" EXACT RESID-systematic []
synonym: "lysine derivative Lys(x)" EXACT RESID-alternate []
synonym: "MOD_RES N6-poly(methylaminopropyl)lysine" EXACT UniProt-feature []
synonym: "N6-[3-([(omega)-(dimethyl)aminopropyl-poly(3-[methylamino]propyl)]amino)propyl]lysine" EXACT RESID-alternate []
synonym: "N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine" EXACT RESID-name []
synonym: "silaffin polycationic lysine derivative" EXACT RESID-alternate []
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0198
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00284
name: dihydroxyheme-L-aspartate ester-L-glutamate ester
def: "A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:10447690, RESID:AA0279]
comment: Cross-link 2.
synonym: "1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester" EXACT RESID-alternate []
synonym: "[13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-7,12-diethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic []
synonym: "BINDING Heme (covalent; via 2 links)" EXACT UniProt-feature []
synonym: "dihydroxyheme-L-aspartate ester-L-glutamate ester" EXACT RESID-name []
synonym: "peroxidase heme cofactor" EXACT RESID-alternate []
xref: DiffAvg: "612.47"
xref: DiffFormula: "C 34 Fe 1 H 28 N 4 O 4"
xref: DiffMono: "612.145993"
xref: Formula: "C 43 Fe 1 H 40 N 6 O 10"
xref: MassAvg: "856.67"
xref: MassMono: "856.215529"
xref: Origin: "D, E"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00699 ! porphyrin modified residue
is_a: MOD:02066 ! metal or metal cluster coordinated L-aspartic acid residue
is_a: MOD:02068 ! metal or metal cluster coordinated L-glutamic acid residue

[Term]
id: MOD:00285
name: dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium
def: "A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, a methionine residue (forming a sulfonium ether), and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:10447690, PubMed:10480885, PubMed:1320128, PubMed:7840679, RESID:AA0280]
comment: Cross-link 3.
synonym: "1,5-bishydroxymethyl protoporphyrin IX 1-glutamate ester 5-aspartate ester 2-methionine sulfonium" EXACT RESID-alternate []
synonym: "[13-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-3-[(S)-(3-amino-3-carboxy)propanoyloxymethyl]-12-[(S)-(3-amino-3-carboxy)propylsulfoniumethyl]-7-ethenyl-8,17-dimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic []
synonym: "BINDING Heme (covalent; via 3 links)" EXACT UniProt-feature []
synonym: "dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium" EXACT RESID-name []
synonym: "myeloperoxidase heme cofactor" EXACT RESID-alternate []
xref: DiffAvg: "613.47"
xref: DiffFormula: "C 34 Fe 1 H 29 N 4 O 4 S 0"
xref: DiffMono: "613.153269"
xref: FormalCharge: "1+"
xref: Formula: "C 48 Fe 1 H 50 N 7 O 11 S 1"
xref: MassAvg: "988.87"
xref: MassMono: "988.263290"
xref: Origin: "D, E, M"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00699 ! porphyrin modified residue
is_a: MOD:02066 ! metal or metal cluster coordinated L-aspartic acid residue
is_a: MOD:02068 ! metal or metal cluster coordinated L-glutamic acid residue
is_a: MOD:02071 ! metal or metal cluster coordinated L-methionine residue

[Term]
id: MOD:00286
name: L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide)
def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0281, Unimod:424#C]
synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate []
synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-cystein-S-yl-molybdenum" EXACT RESID-systematic []
synonym: "L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name []
synonym: "molybdenum bis(molybdopterin guanine dinucleotide)" RELATED Unimod-description []
synonym: "MolybdopterinGD" RELATED PSI-MS-label []
xref: DiffAvg: "1572.02"
xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4"
xref: DiffMono: "1572.985775"
xref: Formula: "C 43 H 52 Mo 1 N 21 O 27 P 4 S 5"
xref: MassAvg: "1675.15"
xref: MassMono: "1675.994960"
xref: Origin: "C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:424"
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:01167 ! molybdopterin guanine dinucleotide

[Term]
id: MOD:00287
name: (2S,3R,4S)-3,4-dihydroxyproline
def: "A protein modification that effectively converts an L-proline residue to a (2S,3R,4S)-3,4-dihydroxyproline." [DeltaMass:0, PubMed:12686488, RESID:AA0282, Unimod:425#P, ChEBI:141803]
comment: From DeltaMass: Average Mass: 32.
synonym: "(2S,3R,4S)-3,4-dihydroxyproline" EXACT RESID-name []
synonym: "(2S,3R,4S)-3,4-dihydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "2,3-trans-3,4-cis-3,4-dihydroxy-L-proline" EXACT RESID-alternate []
synonym: "2-alpha-3-beta-4-beta-3,4-dihydroxyproline" EXACT RESID-alternate []
synonym: "3,4-dihydroxylated L-proline" EXACT PSI-MOD-alternate []
synonym: "3,4-Dihydroxylation (of Proline)" EXACT DeltaMass-label []
synonym: "34Hy2Pro" EXACT PSI-MOD-label []
synonym: "dihydroxy" RELATED Unimod-description []
synonym: "Dioxidation" RELATED PSI-MS-label []
synonym: "MOD_RES (3R,4S)-3,4-dihydroxyproline" EXACT UniProt-feature []
synonym: "trans-2,3-cis-3,4-dihydroxy-L-proline" EXACT RESID-alternate []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:425"
xref: uniprot.ptm:PTM-0306
is_a: MOD:00866 ! dihydroxylated proline

[Term]
id: MOD:00288
name: pyrroloquinoline quinone
def: "A protein modification that effectively doubly cross-links an L-glutamic acid residue and an L-tyrosine residue with a carbon-carbon bond and a carbon-nitrogen bond to form pyrroloquinoline quinone." [ChEBI:18315, PubMed:1310505, PubMed:7665488, RESID:AA0283]
comment: Cross-link 2.
synonym: "2,4,6-tricarboxylic-pyrrolo[2,3-5,6]quinoline 8,9-quinone" EXACT RESID-alternate []
synonym: "2,7,9-tricarboxy-1H-pyrrolo(2,3-f)quinoline-4,5-dione" EXACT RESID-alternate []
synonym: "4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-5,6]quinoline-2,7,9-tricarboxylic acid" EXACT RESID-systematic []
synonym: "coenzyme PQQ" EXACT RESID-alternate []
synonym: "CROSSLNK Pyrroloquinoline quinone (Glu-Tyr)" EXACT UniProt-feature []
synonym: "methoxatin" EXACT RESID-alternate []
synonym: "pyrroloquinoline quinone" EXACT RESID-name []
xref: DiffAvg: "37.92"
xref: DiffFormula: "C 0 H -10 N 0 O 3"
xref: DiffMono: "37.906494"
xref: Formula: "C 14 H 6 N 2 O 8"
xref: MassAvg: "330.21"
xref: MassMono: "330.012415"
xref: Origin: "E, Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0263
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02045 ! crosslinked L-glutamic acid residue
is_a: MOD:02058 ! crosslinked L-tyrosine residue

[Term]
id: MOD:00289
name: tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide
def: "A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide." [PubMed:9836629, RESID:AA0284]
comment: Cross-link 4.
synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature []
synonym: "METAL Iron-sulfur (4Fe-4S); via tele nitrogen" EXACT UniProt-feature []
synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(N1'-histidinoiron)" EXACT RESID-systematic []
synonym: "tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide" EXACT RESID-name []
xref: DiffAvg: "347.59"
xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4"
xref: DiffMono: "347.597831"
xref: FormalCharge: "2-"
xref: Formula: "C 15 Fe 4 H 18 N 6 O 4 S 7"
xref: MassAvg: "794.15"
xref: MassMono: "793.684297"
xref: Origin: "C, C, C, H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00290
name: tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide
def: "A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide." [PubMed:7854413, RESID:AA0285]
comment: Cross-link 4.
synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature []
synonym: "METAL Iron-sulfur (4Fe-4S); via pros nitrogen" EXACT UniProt-feature []
synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(N3'-histidinoiron)" EXACT RESID-systematic []
synonym: "tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide" EXACT RESID-name []
xref: DiffAvg: "347.59"
xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4"
xref: DiffMono: "347.597831"
xref: FormalCharge: "2-"
xref: Formula: "C 15 Fe 4 H 18 N 6 O 4 S 7"
xref: MassAvg: "794.15"
xref: MassMono: "793.684297"
xref: Origin: "C, C, C, H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00291
name: tris-L-cysteinyl L-aspartato tetrairon tetrasulfide
def: "A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-aspartato tetrairon tetrasulfide." [PubMed:7819255, PubMed:9283079, RESID:AA0286]
comment: Cross-link 4.
synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature []
synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(O4-aspartatoiron)" EXACT RESID-systematic []
synonym: "tris-L-cysteinyl L-aspartato tetrairon tetrasulfide" EXACT RESID-name []
xref: DiffAvg: "347.59"
xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4"
xref: DiffMono: "347.597831"
xref: FormalCharge: "2-"
xref: Formula: "C 13 Fe 4 H 16 N 4 O 6 S 7"
xref: MassAvg: "772.09"
xref: MassMono: "771.652328"
xref: Origin: "C, C, C, D"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02066 ! metal or metal cluster coordinated L-aspartic acid residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00292
name: N6-pyruvic acid 2-iminyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-pyruvic acid 2-iminyl-L-lysine." [PubMed:1463470, PubMed:7853400, PubMed:9047371, RESID:AA0287, Unimod:422#K]
synonym: "(2S)-2-amino-6-([1-carboxyethylidene]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "ACT_SITE Schiff-base intermediate with substrate" EXACT UniProt-feature []
synonym: "N-pyruvic acid 2-iminyl" RELATED Unimod-description []
synonym: "N6-pyruvic acid 2-iminyl-L-lysine" EXACT RESID-name []
synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label []
xref: DiffAvg: "70.05"
xref: DiffFormula: "C 3 H 2 N 0 O 2"
xref: DiffMono: "70.005479"
xref: Formula: "C 9 H 14 N 2 O 3"
xref: MassAvg: "198.22"
xref: MassMono: "198.100442"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:422"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01170 ! pyruvic acid iminylated residue

[Term]
id: MOD:00293
name: tris-L-cysteinyl L-serinyl tetrairon tetrasulfide
def: "A protein modification that effectively converts three L-cysteine residues, an L-serine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-serinyl tetrairon tetrasulfide." [RESID:AA0288]
comment: Cross-link 4.
synonym: "tetra-mu3-sulfidotris(S-cysteinyliron)(O3-serinyliron)" EXACT RESID-systematic []
synonym: "tris-L-cysteinyl L-serinyl tetrairon tetrasulfide" EXACT RESID-name []
xref: DiffAvg: "347.59"
xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4"
xref: DiffMono: "347.597831"
xref: FormalCharge: "2-"
xref: Formula: "C 12 Fe 4 H 16 N 4 O 5 S 7"
xref: MassAvg: "744.08"
xref: MassMono: "743.657414"
xref: Origin: "C, C, C, S"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02072 ! metal or metal cluster coordinated L-serine residue

[Term]
id: MOD:00294
name: bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide
def: "A protein modification that effectively converts two L-cysteine residues, an L-histidine residues, an L-serine residue and a four-iron four-sulfur cluster to bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide." [RESID:AA0289]
comment: Cross-link 4.
synonym: "bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide" EXACT RESID-name []
synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature []
synonym: "METAL Iron-sulfur (4Fe-4S); via pros nitrogen" EXACT UniProt-feature []
synonym: "tetra-mu3-sulfidobis(S-cysteinyliron)(N3'-histidinoiron)(O3-serinyliron)" EXACT RESID-systematic []
xref: DiffAvg: "347.59"
xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4"
xref: DiffMono: "347.597831"
xref: FormalCharge: "2-"
xref: Formula: "C 15 Fe 4 H 18 N 6 O 5 S 6"
xref: MassAvg: "778.09"
xref: MassMono: "777.707141"
xref: Origin: "C, C, H, S"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue
is_a: MOD:02072 ! metal or metal cluster coordinated L-serine residue

[Term]
id: MOD:00295
name: O-octanoyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-octanoyl-L-serine." [PubMed:10604470, PubMed:12716131, RESID:AA0290, Unimod:426#S]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(octanoyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "L-serine octanoate ester" EXACT RESID-alternate []
synonym: "LIPID O-octanoyl serine" EXACT UniProt-feature []
synonym: "O-octanoyl-L-serine" EXACT RESID-name []
synonym: "O-octanoylated L-serine" EXACT PSI-MOD-alternate []
synonym: "O3-octanoyl-L-serine" EXACT RESID-alternate []
synonym: "Octanoyl" RELATED PSI-MS-label []
synonym: "octanoyl" RELATED Unimod-description []
synonym: "OOctSer" EXACT PSI-MOD-label []
xref: DiffAvg: "126.20"
xref: DiffFormula: "C 8 H 14 N 0 O 1"
xref: DiffMono: "126.104465"
xref: Formula: "C 11 H 19 N 1 O 3"
xref: MassAvg: "213.28"
xref: MassMono: "213.136493"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:426"
xref: uniprot.ptm:PTM-0239
is_a: MOD:00669 ! O-octanoylated residue
is_a: MOD:02003 ! O3-acylated L-serine

[Term]
id: MOD:00296
name: O-D-glucuronosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-D-glucuronosyl-L-serine." [PubMed:10858503, PubMed:12716131, PubMed:7398618, RESID:AA0291, Unimod:54#S]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(beta-D-glucopyranuronosyl)propanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (GlcA) serine" EXACT UniProt-feature []
synonym: "Glucuronyl" RELATED PSI-MS-label []
synonym: "N-glucuronylation" RELATED Unimod-description []
synonym: "O-D-glucuronosyl-L-serine" EXACT RESID-name []
synonym: "O3-D-glucuronosyl-L-serine" EXACT RESID-alternate []
xref: DiffAvg: "176.12"
xref: DiffFormula: "C 6 H 8 N 0 O 6"
xref: DiffMono: "176.032088"
xref: Formula: "C 9 H 13 N 1 O 8"
xref: MassAvg: "263.20"
xref: MassMono: "263.064116"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:54"
xref: uniprot.ptm:PTM-0577
is_a: MOD:00447 ! N-glucuronylated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00297
name: tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide
def: "A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292]
comment: Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "carbon monoxide dehydrogenase nickel-iron cofactor" EXACT RESID-alternate []
synonym: "hybrid nickel-triiron cluster" EXACT RESID-alternate []
synonym: "mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O5-glutamato 2-nickel-3,4-bis-(S-cysteinyl iron)" EXACT RESID-systematic []
synonym: "Ni-3Fe-2S-3O cluster" EXACT RESID-alternate []
synonym: "tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide" EXACT RESID-name []
xref: DiffAvg: "363.35"
xref: DiffFormula: "C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3"
xref: DiffMono: "362.586337"
xref: Formula: "C 28 Fe 3 H 34 N 9 Ni 1 O 14 S 7"
xref: MassAvg: "1171.28"
xref: MassMono: "1169.767174"
xref: Origin: "C, C, C, C, E, E, H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:00741 ! nickel containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02068 ! metal or metal cluster coordinated L-glutamic acid residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00298
name: tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide
def: "A protein modification that effectively converts four L-cysteine residues, an L-glutamic acid residue, an L-histidine residue, an L-serine residue and a one-nickel three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [PubMed:2550436, RESID:AA0293]
comment: Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "carbon monoxide dehydrogenase nickel-iron cofactor" EXACT RESID-alternate []
synonym: "hybrid nickel-triiron cluster" EXACT RESID-alternate []
synonym: "mu-1:2kappaO-oxido-mu-1:3kappaO-oxido-mu-2:4kappaO-oxido-mu-3:4kappaS-sulfido-mu3-2:3:4kappaS-sulfido-S-cysteinyl-N1'-histidino-O5-glutamato 1-iron-S5-cysteine persulfido-O3-serinyl 2-nickel-3,4-bis-(S-cysteinyl iron)" EXACT RESID-systematic []
synonym: "Ni-3Fe-2S-3O cluster" EXACT RESID-alternate []
synonym: "tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide" EXACT RESID-name []
xref: DiffAvg: "363.35"
xref: DiffFormula: "C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3"
xref: DiffMono: "362.586337"
xref: Formula: "C 26 Fe 3 H 32 N 9 Ni 1 O 13 S 7"
xref: MassAvg: "1129.24"
xref: MassMono: "1127.756609"
xref: Origin: "C, C, C, C, E, H, S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:00741 ! nickel containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02068 ! metal or metal cluster coordinated L-glutamic acid residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue
is_a: MOD:02072 ! metal or metal cluster coordinated L-serine residue

[Term]
id: MOD:00299
name: N6-(L-isoaspartyl)-L-lysine (Asn)
def: "A protein modification that effectively crosslinks an L-asparagine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of ammonia." [ChEBI:21862, DeltaMass:0, PubMed:11000116, PubMed:6503713, RESID:AA0294]
comment: Cross-link 2.
synonym: "(2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "beta-(N6-lysyl)aspartyl acid" EXACT RESID-alternate []
synonym: "CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn)" EXACT UniProt-feature []
synonym: "isoaspartyl N6-lysine" EXACT RESID-alternate []
synonym: "N(epsilon)-(beta-aspartyl)lysine" EXACT RESID-alternate []
synonym: "N-(beta-Aspartyl)-Lysine (Crosslink)" EXACT DeltaMass-label []
synonym: "N6-(L-isoaspartyl)-L-lysine" EXACT RESID-name []
synonym: "XLNK-4Asp-N6Lys(Asn)" EXACT PSI-MOD-label []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 10 H 15 N 3 O 3"
xref: MassAvg: "225.25"
xref: MassMono: "225.111341"
xref: Origin: "K, N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0153
is_a: MOD:02042 ! crosslinked L-asparagine residue
is_a: MOD:00946 ! crosslinked residues with loss of ammonia
is_a: MOD:01929 ! N6-(L-isoaspartyl)-L-lysine

[Term]
id: MOD:00300
name: L-glutamyl-5-poly(ADP-ribose)
def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl-5-poly(ADP-ribose)." [DeltaMass:0, PubMed:11246023, PubMed:15842200, PubMed:8533153, RESID:AA0295, Unimod:213#E]
synonym: "(S)-2-amino-5-poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl]oxy-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "ADP Ribose addition" RELATED Unimod-description []
synonym: "ADP-Ribosyl" RELATED PSI-MS-label []
synonym: "L-glutamyl-5-poly(ADP-ribose)" EXACT RESID-name []
synonym: "L-isoglutamyl-poly(ADP-ribose)" EXACT RESID-alternate []
synonym: "MOD_RES PolyADP-ribosyl glutamic acid" EXACT UniProt-feature []
synonym: "O-ADP-ribosylation (on Glutamate or C terminus)" EXACT DeltaMass-label []
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:213"
is_a: MOD:02087 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:00301
name: O-(N-acetylglucosamine-1-phosphoryl)-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-(N-acetylglucosamine-1-phosphoryl)-L-serine." [DeltaMass:0, PubMed:6438439, PubMed:6993483, PubMed:8631906, RESID:AA0296, Unimod:428]
synonym: "(2S)-2-amino-3-[([(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)oxy][hydroxy]phosphoryl)oxy]propanoic acid" EXACT RESID-systematic []
synonym: "N-acetylglucosamine-1-phosphoryl" RELATED Unimod-description []
synonym: "O-(N-acetylglucosamine-1-phosphoryl)-L-serine" EXACT RESID-name []
synonym: "O-beta(N-acetyl-glucosamine-alpha1-phosphate)serine" EXACT RESID-alternate []
synonym: "O-GlcNAc-1-phosphorylation (of Serine)" EXACT DeltaMass-label []
synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine" EXACT RESID-alternate []
synonym: "O3-L-serine 2-(acetylamino)-2-deoxy-D-glucopyranose 1-phosphodiester" EXACT RESID-alternate []
synonym: "PhosphoHexNAc" RELATED PSI-MS-label []
synonym: "CARBOHYD O-linked (GalNAcP) serine" EXACT UniProt-feature []
xref: DiffAvg: "283.17"
xref: DiffFormula: "C 8 H 14 N 1 O 8 P 1"
xref: DiffMono: "283.045703"
xref: Formula: "C 11 H 19 N 2 O 10 P 1"
xref: MassAvg: "370.25"
xref: MassMono: "370.077731"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:428"
xref: uniprot.ptm:PTM-0586
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01804 ! glycosylphosphorylated residue

[Term]
id: MOD:00302
name: O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine." [PubMed:10037765, PubMed:15649890, RESID:AA0297, Unimod:429]
synonym: "O-(alpha-D-mannosyl-1-phosphoryl)-L-serine" EXACT RESID-alternate []
synonym: "O-(D-mannose-1-phosphoryl)-L-serine" EXACT RESID-name []
synonym: "O-[alpha-D-mannopyranosyloxy(hydroxy)phosphoryl]-L-serine" EXACT RESID-systematic []
synonym: "O3-(D-mannose-1-phosphoryl)-L-serine" EXACT RESID-alternate []
synonym: "O3-L-serine alpha-D-mannopyranose 1-phosphodiester" EXACT RESID-alternate []
synonym: "phosphoglycosyl-D-mannose-1-phosphoryl" RELATED Unimod-description []
synonym: "PhosphoHex" RELATED PSI-MS-label []
synonym: "CARBOHYD O-linked (Man1P) serine" EXACT UniProt-feature []
xref: DiffAvg: "242.12"
xref: DiffFormula: "C 6 H 11 N 0 O 8 P 1"
xref: DiffMono: "242.019154"
xref: Formula: "C 9 H 16 N 1 O 10 P 1"
xref: MassAvg: "329.20"
xref: MassMono: "329.051182"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:429"
xref: uniprot.ptm:PTM-0594
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01804 ! glycosylphosphorylated residue

[Term]
id: MOD:00303
name: heptakis-L-histidino tetracopper mu4-sulfide hydroxide
def: "A protein modification that effectively converts seven L-histidinine residues and a four-copper one-sulfur one-hydroxide cluster to heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [PubMed:11024061, PubMed:11041839, RESID:AA0298]
comment: Cross-link 7.
synonym: "heptakis-L-histidino tetracopper mu4-sulfide hydroxide" EXACT RESID-name []
synonym: "mu4-sulfido bis(bis-N1'-histidino copper)(N1'-histidino-N3'-histidino copper)(N3'-histidino hydroxide copper)" EXACT RESID-systematic []
synonym: "nitrous oxide reductase nosZ CuZ cluster" EXACT RESID-alternate []
synonym: "pentakis-L-N1'-histidino-bis-L-N3'-histidino tetracopper sulfide hydroxide" EXACT RESID-alternate []
xref: DiffAvg: "296.19"
xref: DiffFormula: "C 0 Cu 4 H -6 N 0 O 1 S 1"
xref: DiffMono: "293.638425"
xref: Formula: "C 42 Cu 4 H 43 N 21 O 8 S 1"
xref: MassAvg: "1256.19"
xref: MassMono: "1253.050808"
xref: Origin: "H, H, H, H, H, H, H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00742 ! copper containing modified residue
is_a: MOD:00860 ! sulfur containing modified residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00304
name: L-leucine methyl ester
def: "A protein modification that effectively converts an L-leucine residue to L-leucine methyl ester." [PubMed:10191253, PubMed:11875433, PubMed:8206937, RESID:AA0299, Unimod:34#C-term]
comment: incidental to RESID:AA0039
subset: PSI-MOD-slim
synonym: "2-amino-4-methylpentanoic methyl ester" EXACT RESID-alternate []
synonym: "alpha-aminoisocaproic methyl ester" EXACT RESID-alternate []
synonym: "L-leucine methyl ester" EXACT RESID-name []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "methyl (2S)-2-amino-4-methylpentanoate" EXACT RESID-systematic []
synonym: "methyl esterified L-leucine" EXACT PSI-MOD-alternate []
synonym: "methyl L-leucinate" EXACT RESID-alternate []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES Leucine methyl ester" EXACT UniProt-feature []
synonym: "OMeLeu" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 14 N 1 O 2"
xref: MassAvg: "144.19"
xref: MassMono: "144.102454"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:34"
xref: uniprot.ptm:PTM-0167
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00662 ! methylated leucine
is_a: MOD:01689 ! alpha-carboxyl methylated residue

[Term]
id: MOD:00305
name: hexakis-L-cysteinyl L-serinyl octairon heptasulfide
def: "A protein modification that effectively converts six L-cysteine residues, an L-serine residue and a eight-iron seven-sulfur cluster to hexakis-L-cysteinyl L-serinyl octairon heptasulfide." [PubMed:10525412, PubMed:12215645, PubMed:9063865, RESID:AA0300]
comment: Cross-link 7; incidental to RESID:AA0141.
synonym: "Cys6Ser-[8Fe7S]" EXACT PSI-MOD-label []
synonym: "hexakis-L-cysteinyl L-serinyl octairon heptasulfide" EXACT RESID-name []
synonym: "METAL Iron-sulfur (8Fe-7S)" EXACT UniProt-feature []
synonym: "nitrogenase P-cluster" EXACT RESID-alternate []
xref: DiffAvg: "663.12"
xref: DiffFormula: "C 0 Fe 8 H -8 N 0 O 0 S 7"
xref: DiffMono: "663.223042"
xref: FormalCharge: "3-"
xref: Formula: "C 21 Fe 8 H 27 N 7 O 8 S 13"
xref: MassAvg: "1369.03"
xref: MassMono: "1368.310179"
xref: Origin: "C, C, C, C, C, C, S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02072 ! metal or metal cluster coordinated L-serine residue

[Term]
id: MOD:00306
name: residues isobaric at 113.084064 Da
def: "Natural or modified residues with a mass of 113.084064 Da." [PubMed:10523135, RESID:AA0301]
subset: PSI-MOD-slim
synonym: "L-isoleucine or L-leucine" EXACT RESID-name []
synonym: "Xle" EXACT PSI-MOD-label []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 6 H 11 N 1 O 1"
xref: MassAvg: "113.16"
xref: MassMono: "113.084064"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da
is_a: MOD:00624 ! residues isobaric at 113.0-113.1 Da

[Term]
id: MOD:00307
name: L-aspartimide
def: "A protein modification that effectively cyclizes an L-asparagine residue to form a carboxyl-terminal L-aspartimide." [DeltaMass:18, PubMed:12771378, PubMed:2378679, PubMed:7662664, PubMed:7988548, PubMed:9309583, RESID:AA0302, Unimod:23#N]
comment: From DeltaMass: Average Mass: -17 Average Mass Change:-17 References:Clarke, S., Lability of Aspargine and Aspartic Acid Residues in Protein and Peptides, in: Stability of Protein Pharmaceuticals : Chemical and Physical Paths of Protein Degradation, Part A (T.J. Ahern and M.C. Manning, eds.), 1992,Plenum Press, New York, pp.1-29Xie, M.; Vander Velde, D.; Morton, M.; Borchardt, R.T.; Schowen,R.L.: pH-Induced Change in the Rate-Determining Step for the Hydrolysis of the Asp/Asn-Derived Cyclic-Imide Intermediate in Protein Degradation. (1996) J. Am. Chem. Soc. 118: 8955-8956.
synonym: "(3S)-3-amino-2,5-pyrrolidinedione" EXACT RESID-systematic []
synonym: "2-amino-butanimide" EXACT RESID-alternate []
synonym: "alpha-aminosuccinimide" EXACT RESID-alternate []
synonym: "ASI" EXACT RESID-alternate []
synonym: "Dehydrated" RELATED Unimod-interim []
synonym: "Dehydration" RELATED Unimod-description []
synonym: "L-2-aminosuccinimide" EXACT RESID-alternate []
synonym: "L-3-aminosuccinimide" RELATED RESID-misnomer []
synonym: "L-asparaginimide" EXACT RESID-alternate []
synonym: "L-aspartimide" EXACT RESID-name []
synonym: "Succinimide formation from asparagine" EXACT DeltaMass-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 4 H 5 N 2 O 2"
xref: MassAvg: "113.10"
xref: MassMono: "113.035102"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:23"
is_a: MOD:00601 ! cyclized residue
is_a: MOD:00704 ! dehydrated residue
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:00308
name: L-glutamimide
def: "A protein modification that effectively cyclizes an L-glutamine residue to form a carboxyl-terminal L-glutamimide." [PubMed:12771378, PubMed:14593103, RESID:AA0303, Unimod:23#Q]
synonym: "(3S)-3-aminopiperidine-2,6-dione" EXACT RESID-systematic []
synonym: "2-aminopentanimide" EXACT RESID-alternate []
synonym: "3-amino-2,6-piperidinedione" EXACT RESID-alternate []
synonym: "alpha-aminoglutarimide" EXACT RESID-alternate []
synonym: "Dehydrated" RELATED Unimod-interim []
synonym: "Dehydration" RELATED Unimod-description []
synonym: "L-glutamimide" EXACT RESID-name []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 5 H 7 N 2 O 2"
xref: MassAvg: "127.12"
xref: MassMono: "127.050752"
xref: Origin: "Q"
xref: Source: "hypothetical"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:23"
is_a: MOD:00601 ! cyclized residue
is_a: MOD:00704 ! dehydrated residue
is_a: MOD:00907 ! modified L-glutamine residue

[Term]
id: MOD:00309
name: L-beta-carboxyaspartic acid
def: "A protein modification that effectively converts an L-aspartic acid residue to L-beta-carboxyaspartic acid." [OMSSA:47, PubMed:6390094, PubMed:7138832, PubMed:7457858, PubMed:8135347, RESID:AA0304, Unimod:299#D]
comment: References to this modification as a gamma-carboxylation are in error [JSG].
synonym: "(2S)-2-aminoethane-1,1,2-tricarboxylic acid" EXACT RESID-systematic []
synonym: "2-amino-3-carboxybutanedioic acid" EXACT RESID-alternate []
synonym: "3-carboxy-L-aspartic acid" EXACT RESID-name []
synonym: "3-carboxyaspartic acid" EXACT RESID-alternate []
synonym: "3CbxAsp" EXACT PSI-MOD-label []
synonym: "beta-carboxyaspartic acid" EXACT RESID-alternate []
synonym: "Carboxy" RELATED PSI-MS-label []
synonym: "Carboxy" RELATED Unimod-interim []
synonym: "Carboxylation" RELATED Unimod-description []
synonym: "gammacarboxyld" EXACT OMSSA-label []
xref: DiffAvg: "44.01"
xref: DiffFormula: "C 1 H 0 N 0 O 2"
xref: DiffMono: "43.989829"
xref: Formula: "C 5 H 5 N 1 O 5"
xref: MassAvg: "159.10"
xref: MassMono: "159.016772"
xref: Origin: "D"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:299"
is_a: MOD:00904 ! modified L-aspartic acid residue
is_a: MOD:01152 ! carboxylated residue

[Term]
id: MOD:00310
name: N5-methyl-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to N5-methyl-L-arginine." [PubMed:11875433, PubMed:9792625, PubMed:9873020, RESID:AA0305]
synonym: "(2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic acid" EXACT RESID-systematic []
synonym: "delta-N-methylarginine" EXACT RESID-alternate []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES N5-methylarginine" EXACT UniProt-feature []
synonym: "N5-carbamimidoyl-N5-methyl-L-ornithine" EXACT RESID-alternate []
synonym: "N5-methyl-L-arginine" EXACT RESID-name []
synonym: "N5-methylated L-arginine" EXACT PSI-MOD-alternate []
synonym: "N5Me1Arg" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 14 N 4 O 1"
xref: MassAvg: "170.22"
xref: MassMono: "170.116761"
xref: Origin: "R"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0185
is_a: MOD:00414 ! monomethylated L-arginine
is_a: MOD:00602 ! N-methylated residue

[Term]
id: MOD:00311
name: L-cysteine coenzyme A disulfide
def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine coenzyme A disulfide." [DeltaMass:0, PubMed:1734967, RESID:AA0306, Unimod:281#C]
comment: DeltaMass gives no formula with mass as 454.
synonym: "(2R)-2-amino-3-(2-((3-(((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)amino)-1-oxopropyl)amino)ethyl)dithio-propanoic acid 4'-ester with adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate)" EXACT RESID-systematic []
synonym: "coenzyme A L-cysteine mixed disulfide" EXACT RESID-alternate []
synonym: "CoenzymeA" RELATED PSI-MS-label []
synonym: "Cysteine modified Coenzyme A" RELATED Unimod-description []
synonym: "L-cysteine coenzyme A disulfide" EXACT RESID-name []
synonym: "SCoACys" EXACT PSI-MOD-label []
xref: DiffAvg: "765.52"
xref: DiffFormula: "C 21 H 34 N 7 O 16 P 3 S 1"
xref: DiffMono: "765.099559"
xref: Formula: "C 24 H 39 N 8 O 17 P 3 S 2"
xref: MassAvg: "868.66"
xref: MassMono: "868.108744"
xref: Origin: "C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:281"
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01862 ! disulfide conjugated residue

[Term]
id: MOD:00312
name: S-myristoyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-myristoyl-L-cysteine." [PubMed:10026218, PubMed:10080938, PubMed:8824274, RESID:AA0307, Unimod:45#C]
synonym: "(R)-2-amino-3-(tetradecanoylsulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "LIPID S-myristoyl cysteine" EXACT UniProt-feature []
synonym: "Myristoyl" RELATED PSI-MS-label []
synonym: "Myristoylation" RELATED Unimod-description []
synonym: "S-(C14:1 aliphatic acyl)cysteine" EXACT PSI-MOD-alternate []
synonym: "S-myristoyl-L-cysteine" EXACT RESID-name []
synonym: "S-myristoylated L-cysteine" EXACT PSI-MOD-alternate []
synonym: "SMyrCys" EXACT PSI-MOD-label []
synonym: "tetradecanoate cysteine thioester" EXACT RESID-alternate []
xref: DiffAvg: "210.36"
xref: DiffFormula: "C 14 H 26 N 0 O 1 S 0"
xref: DiffMono: "210.198365"
xref: Formula: "C 17 H 31 N 1 O 2 S 1"
xref: MassAvg: "313.50"
xref: MassMono: "313.207550"
xref: Origin: "C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:45"
is_a: MOD:00655 ! S-myristoylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00313
name: S-palmitoleyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-palmitoleyl-L-cysteine." [OMSSA:187, PubMed:8294460, RESID:AA0308, Unimod:431#C]
synonym: "(R)-2-amino-3-((Z)-9-hexadecenoylsulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "cis-9-hexadecenoate cysteine thioester" EXACT RESID-alternate []
synonym: "mod187" EXACT OMSSA-label []
synonym: "Palmitoleyl" RELATED PSI-MS-label []
synonym: "palmitoleyl" RELATED Unimod-description []
synonym: "S-palmitoleyl-L-cysteine" EXACT RESID-name []
synonym: "S-palmitoleylated L-cysteine" EXACT PSI-MOD-alternate []
synonym: "SPamD1Cys" EXACT PSI-MOD-label []
xref: DiffAvg: "236.40"
xref: DiffFormula: "C 16 H 28 N 0 O 1 S 0"
xref: DiffMono: "236.214016"
xref: Formula: "C 19 H 33 N 1 O 2 S 1"
xref: MassAvg: "339.54"
xref: MassMono: "339.223200"
xref: Origin: "C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:431"
xref: uniprot.ptm:PTM-0645
is_a: MOD:02002 ! S-palmitoleylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00314
name: glycine cholesterol ester
def: "A protein modification that effectively converts a glycine residue to glycine cholesterol ester." [PubMed:11111088, PubMed:8824192, RESID:AA0309, Unimod:432#C-term, ChEBI:143135]
comment: Incidental to RESID:AA0060. Unimod origin corrected [JSG].
subset: PSI-MOD-slim
synonym: "C-cholesterol" RELATED Unimod-interim []
synonym: "cholesterol ester" RELATED Unimod-description []
synonym: "cholesteryl glycinate" EXACT RESID-alternate []
synonym: "glycine cholest-5-en-3beta-ol ester" EXACT RESID-systematic []
synonym: "glycine cholesterol ester" EXACT RESID-name []
synonym: "hedgehog lipophilic adduct" EXACT RESID-alternate []
synonym: "LIPID Cholesterol glycine ester" EXACT UniProt-feature []
xref: DiffAvg: "368.65"
xref: DiffFormula: "C 27 H 44 N 0 O 0"
xref: DiffMono: "368.344301"
xref: Formula: "C 29 H 48 N 1 O 2"
xref: MassAvg: "442.71"
xref: MassMono: "442.368505"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:432"
xref: uniprot.ptm:PTM-0090
is_a: MOD:00908 ! modified glycine residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00315
name: pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide
def: "A protein modification that effectively converts five L-cysteine residues, an L-histidine residue and a one-nickel four-iron five-sulfur cluster to pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide." [PubMed:11509720, PubMed:2550436, RESID:AA0310]
comment: Cross-link 6.
synonym: "carbon monoxide dehydrogenase nickel-iron cofactor" EXACT RESID-alternate []
synonym: "METAL Nickel-iron-sulfur (Ni-4Fe-5S)" EXACT UniProt-feature []
synonym: "METAL Nickel-iron-sulfur (Ni-4Fe-5S); via tele nitrogen" EXACT UniProt-feature []
synonym: "mu-1:2kappaS-sulfido-mu3-1:3:5kappaS-sulfido-mu3-2:3:4kappaS-sulfido-mu3-2:4:5kappaS-sulfido-mu3-3:4:5kappaS-sulfido-N1'-histidino-S-cysteinyl-1-iron-S-cysteinyl-2-nickel-3,4,5-tris-(S-cysteinyl iron)" EXACT RESID-systematic []
synonym: "Ni-4Fe-5S cluster" EXACT RESID-alternate []
synonym: "pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide" EXACT RESID-name []
xref: DiffAvg: "436.33"
xref: DiffFormula: "C 0 Fe 4 H -6 N 0 Ni 1 O 0 S 5"
xref: DiffMono: "435.488498"
xref: Formula: "C 21 Fe 4 H 26 N 8 Ni 1 O 6 S 10"
xref: MassAvg: "1089.16"
xref: MassMono: "1087.593333"
xref: Origin: "C, C, C, C, C, H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:00741 ! nickel containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00316
name: N4,N4-dimethyl-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to N4,N4-dimethyl-L-asparagine." [PubMed:12964758, PubMed:14570711, PubMed:8783012, RESID:AA0311, Unimod:36#N]
synonym: "(2S)-2-amino-4-(dimethylamino)-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "2-amino-N4,N4-dimethylbutanediamic acid" EXACT RESID-alternate []
synonym: "beta-dimethylasparagine" RELATED RESID-misnomer []
synonym: "di-Methylation" RELATED Unimod-description []
synonym: "Dimethyl" RELATED PSI-MS-label []
synonym: "MOD_RES N4,N4-dimethylasparagine" EXACT UniProt-feature []
synonym: "N(gamma),N(gamma)-dimethylasparagine" EXACT RESID-alternate []
synonym: "N4,N4-dimethyl-L-asparagine" EXACT RESID-name []
synonym: "N4,N4-dimethylated L-asparagine" EXACT PSI-MOD-alternate []
synonym: "N4Me2Asn" EXACT PSI-MOD-label []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4 N 0 O 0"
xref: DiffMono: "28.031300"
xref: Formula: "C 6 H 10 N 2 O 2"
xref: MassAvg: "142.16"
xref: MassMono: "142.074228"
xref: Origin: "N"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:36"
xref: uniprot.ptm:PTM-0182
is_a: MOD:00429 ! dimethylated residue
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:00673 ! methylated asparagine

[Term]
id: MOD:00317
name: N6-3,4-didehydroretinylidene-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-3,4-didehydroretinylidene-L-lysine." [PubMed:10717661, PubMed:3257009, PubMed:4056688, RESID:AA0312, Unimod:433#K]
synonym: "(S)-2-amino-6-[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT RESID-systematic []
synonym: "3,4-didehydroretinylidene" RELATED Unimod-description []
synonym: "Didehydroretinylidene" RELATED PSI-MS-label []
synonym: "N6-(3,4-didehydroretinylidene)-L-lysine" EXACT RESID-name []
synonym: "N6-3-dehydroretinal-L-lysine" EXACT RESID-alternate []
synonym: "N6-3-dehydroretinyl-lysine" EXACT RESID-alternate []
xref: DiffAvg: "264.41"
xref: DiffFormula: "C 20 H 24 N 0 O 0"
xref: DiffMono: "264.187801"
xref: Formula: "C 26 H 36 N 2 O 1"
xref: MassAvg: "392.59"
xref: MassMono: "392.282764"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:433"
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00318
name: 4'-(S-L-cysteinyl)-L-tryptophyl quinone
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone." [PubMed:11555656, PubMed:11717396, RESID:AA0313]
comment: Cross-link 2; secondary to RESID:AA0148.
synonym: "(2R)-2-amino-3-[(3-[(2S)-2-amino-2-carboxyethyl]-6,7-dioxo-6,7-dihydro-1H-indol-4-yl)sulfanyl]propanoic acid" EXACT RESID-systematic []
synonym: "3-(2-amino-2-carboxyethyl)-4-[2-amino-2-carboxyethyl]sulfanyl-6,7-indolinedione" EXACT RESID-alternate []
synonym: "4'-(L-cystein-S-yl)-L-tryptophyl quinone" EXACT RESID-name []
synonym: "4-(S-cysteinyl)tryptophan-6,7-dione" EXACT RESID-alternate []
synonym: "CROSSLNK 4'-cysteinyl-tryptophylquinone (Cys-Trp)" EXACT UniProt-feature []
synonym: "CTQ" EXACT RESID-alternate []
synonym: "cysteine tryptophylquinone" EXACT RESID-alternate []
xref: DiffAvg: "27.97"
xref: DiffFormula: "C 0 H -4 N 0 O 2 S 0"
xref: DiffMono: "27.958529"
xref: Formula: "C 14 H 11 N 3 O 4 S 1"
xref: MassAvg: "317.32"
xref: MassMono: "317.047027"
xref: Origin: "C, W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0041
is_a: MOD:00687 ! thioether crosslinked residues
is_a: MOD:02057 ! crosslinked L-tryptophan residue

[Term]
id: MOD:00319
name: 3-(S-L-cysteinyl)-L-aspartic acid
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-aspartic acid residue by a thioether bond to form 2-(S-L-cysteinyl)-L-aspartic acid." [PubMed:11555656, PubMed:11717396, RESID:AA0314]
comment: Cross-link 2.
synonym: "(2R,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanedioic acid" EXACT RESID-systematic []
synonym: "(2R,3S,6R)-2,6-diamino-3-carboxy-4-thiaheptanedioic acid" EXACT RESID-alternate []
synonym: "3-(L-cystein-S-yl)-L-aspartic acid" EXACT RESID-name []
synonym: "3-carboxy-L-lanthionine" EXACT RESID-alternate []
synonym: "CROSSLNK 3-cysteinyl-aspartic acid (Cys-Asp)" EXACT UniProt-feature []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 7 H 8 N 2 O 4 S 1"
xref: MassAvg: "216.21"
xref: MassMono: "216.020478"
xref: Origin: "C, D"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0025
is_a: MOD:02043 ! crosslinked L-aspartic acid residue
is_a: MOD:01993 ! beta-carbon thioether crosslinked residues

[Term]
id: MOD:00320
name: 4-(S-L-cysteinyl)-L-glutamic acid
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-glutamic acid residue by a thioether bond to form 4-(S-L-cysteinyl)-L-glutamic acid." [ChEBI:20293, PubMed:11555656, PubMed:11717396, RESID:AA0315]
comment: Cross-link 2.
synonym: "(2S,3S,7R)-2,7-diamino-4-carboxy-5-thiaoctanedioic acid" EXACT RESID-alternate []
synonym: "(2S,4S)-2-amino-4-[(R)-2-amino-2-carboxyethyl]sulfanylpentanedioic acid" EXACT RESID-systematic []
synonym: "4-(L-cystein-S-yl)-L-glutamic acid" EXACT RESID-name []
synonym: "CROSSLNK 4-cysteinyl-glutamic acid (Cys-Glu)" EXACT UniProt-feature []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 8 H 10 N 2 O 4 S 1"
xref: MassAvg: "230.24"
xref: MassMono: "230.036128"
xref: Origin: "C, E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0040
is_a: MOD:00687 ! thioether crosslinked residues
is_a: MOD:02045 ! crosslinked L-glutamic acid residue

[Term]
id: MOD:00321
name: cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester
def: "A protein modification that effectively converts an L-aspartic acid residue to cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester." [PubMed:11435437, PubMed:7949339, RESID:AA0316, Unimod:434#D]
synonym: "(7Z,14Xi)-14-[(S)-3-amino-3-carboxy-propanoyl]oxy-10,13-dioxo-7-heptadecenoic acid" EXACT RESID-systematic []
synonym: "barley lipid transfer protein modification" EXACT RESID-alternate []
synonym: "CHDH" RELATED PSI-MS-label []
synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester" EXACT RESID-name []
synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic ester" RELATED Unimod-description []
synonym: "LIPID Cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester" EXACT UniProt-feature []
xref: DiffAvg: "294.39"
xref: DiffFormula: "C 17 H 26 N 0 O 4"
xref: DiffMono: "294.183109"
xref: Formula: "C 21 H 31 N 1 O 7"
xref: MassAvg: "409.48"
xref: MassMono: "409.210052"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:434"
xref: uniprot.ptm:PTM-0091
is_a: MOD:00904 ! modified L-aspartic acid residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00322
name: 1'-methyl-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to tele-methyl-L-histidine." [PubMed:10601317, PubMed:11474090, PubMed:11875433, PubMed:6692818, PubMed:8076, PubMed:8645219, RESID:AA0317]
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic []
synonym: "1'-methyl-L-histidine" EXACT RESID-name []
synonym: "3-methylhistidine" RELATED RESID-misnomer []
synonym: "4-methyl-histidine" RELATED RESID-misnomer []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES Tele-methylhistidine" EXACT UniProt-feature []
synonym: "N(epsilon)-methylhistidine" EXACT RESID-alternate []
synonym: "N(tau)-methylhistidine" EXACT RESID-alternate []
synonym: "NteleMeHis" EXACT PSI-MOD-label []
synonym: "tele-methylated L-histidine" EXACT PSI-MOD-alternate []
synonym: "tele-methylhistidine" EXACT RESID-alternate []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 9 N 3 O 1"
xref: MassAvg: "151.17"
xref: MassMono: "151.074562"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0290
is_a: MOD:02038 ! monomethylated L-histidine
is_a: MOD:00724 ! N-methylated L-histidine

[Term]
id: MOD:00323
name: L-lysine methyl ester
def: "A protein modification that effectively converts an L-lysine residue to L-lysine methyl ester." [PubMed:10973948, PubMed:11875433, RESID:AA0318, Unimod:34#C-term]
subset: PSI-MOD-slim
synonym: "2,6-diaminohexanoic methyl ester" EXACT RESID-alternate []
synonym: "alpha,epsilon-diaminocaproic methyl ester" EXACT RESID-alternate []
synonym: "L-lysine methyl ester" EXACT RESID-name []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "methyl (S)-2,6-diaminohexanoate" EXACT RESID-systematic []
synonym: "methyl esterified L-lysine" EXACT PSI-MOD-alternate []
synonym: "methyl L-lysinate" EXACT RESID-alternate []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES Lysine methyl ester" EXACT UniProt-feature []
synonym: "OMeLys" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 15 N 2 O 2"
xref: MassAvg: "159.21"
xref: MassMono: "159.113353"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:34"
xref: uniprot.ptm:PTM-0170
is_a: MOD:01683 ! monomethylated L-lysine
is_a: MOD:01689 ! alpha-carboxyl methylated residue

[Term]
id: MOD:00324
name: L-serinyl molybdenum bis(molybdopterin guanine dinucleotide)
def: "A protein modification that effectively converts an L-serine residue to L-serinyl molybdenum bis(molybdopterin guanine dinucleotide)." [PubMed:8658132, PubMed:8658134, RESID:AA0319]
synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate []
synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-O3-serinyl-molybdenum oxide" EXACT RESID-systematic []
synonym: "L-serinyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name []
xref: DiffAvg: "1588.01"
xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 27 P 4 S 4"
xref: DiffMono: "1588.980690"
xref: Formula: "C 43 H 52 Mo 1 N 21 O 29 P 4 S 4"
xref: MassAvg: "1675.09"
xref: MassMono: "1676.012718"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00744 ! molybdenum pterin containing modification
is_a: MOD:02072 ! metal or metal cluster coordinated L-serine residue

[Term]
id: MOD:00325
name: L-beta-methylthioasparagine
def: "A protein modification that effectively converts an L-asparagine residue to L-beta-methylthioasparagine." [RESID:AA0320, Unimod:39#N]
comment: This modification was predicted for ribosomal protein S12 in Bacillus subtilis when the sequence in the original version of the genome was reported to have asparagine rather than aspartic acid at the position of the methylthioaspartic acid modification (see MOD:00237). Two groups independently confirmed that the genome sequence was incorrect. The sequence in the revised genome has aspartic acid at that position. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "(2R,3Xi)-2-amino-3-(methylsulfanyl)-4-butanediamic acid" EXACT RESID-systematic []
synonym: "2,4-diamino-3-(methylsulfanyl)-4-oxobutanoic acid" EXACT RESID-alternate []
synonym: "3-(methylthio)-L-asparagine" EXACT RESID-name []
synonym: "3-carboxamido-S-methyl-cysteine" EXACT RESID-alternate []
synonym: "beta-(methylthio)asparagine" EXACT RESID-alternate []
synonym: "Beta-methylthiolation" RELATED Unimod-description []
synonym: "Methylthio" RELATED Unimod-interim []
xref: DiffAvg: "46.09"
xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1"
xref: DiffMono: "45.987721"
xref: Formula: "C 5 H 8 N 2 O 2 S 1"
xref: MassAvg: "160.19"
xref: MassMono: "160.030649"
xref: Origin: "N"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:39"
is_a: MOD:00903 ! modified L-asparagine residue
is_a: MOD:01153 ! methylthiolated residue

[Term]
id: MOD:00326
name: L-pyrrolysine (Lys)
def: "A protein modification that effectively converts an L-lysine residue to L-pyrrolysine (not known as a natural, post-translational modification process)." [PubMed:11435424, PubMed:12029131, PubMed:12029132, PubMed:15314242, PubMed:16096277, RESID:AA0321#LYS, Unimod:435#K]
comment: This entry is for the artifactual formation of L-pyrrolysine from lysine. For encoded L-pyrrolysine, use MOD:01187 [JSG].
synonym: "(2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid" EXACT RESID-alternate []
synonym: "L-pyrrolysine" EXACT RESID-name []
synonym: "monomethylamine methyltransferase cofactor lysine adduct" EXACT RESID-alternate []
synonym: "N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine" EXACT RESID-alternate []
synonym: "N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine" EXACT RESID-alternate []
synonym: "N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine" EXACT RESID-alternate []
synonym: "NON_STD Pyrrolysine" EXACT UniProt-feature []
synonym: "Pyl(Lys)" EXACT PSI-MOD-label []
xref: DiffAvg: "109.13"
xref: DiffFormula: "C 6 H 7 N 1 O 1"
xref: DiffMono: "109.052764"
xref: Formula: "C 12 H 19 N 3 O 2"
xref: MassAvg: "237.30"
xref: MassMono: "237.147727"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:435"
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00327
name: 3-hydroxy-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to a 3-hydroxy-L-tryptophan." [PubMed:10024453, PubMed:11457355, RESID:AA0322, ChEBI:141794]
synonym: "(2S,3S)-2-amino-3-hydroxy-3-(1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "3-hydroxy-L-tryptophan" EXACT RESID-name []
synonym: "3-hydroxylated L-tryptophan" EXACT PSI-MOD-alternate []
synonym: "3-hydroxytryptophan" EXACT RESID-alternate []
synonym: "3HyTrp" EXACT PSI-MOD-label []
synonym: "beta-hydroxytryptophan" EXACT RESID-alternate []
synonym: "MOD_RES 3-hydroxytryptophan" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 11 H 10 N 2 O 2"
xref: MassAvg: "202.21"
xref: MassMono: "202.074228"
xref: Origin: "W"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0031
is_a: MOD:01622 ! monohydroxylated tryptophan

[Term]
id: MOD:00328
name: O4'-(phospho-3'-DNA)-L-tyrosine
def: "A protein modification that effectively crosslinks an L-tyrosine residue and the 3'-end of DNA through a phosphodiester bond to form O4'-(phospho-3'-DNA)-L-tyrosine." [PubMed:2211714, RESID:AA0323]
synonym: "(S)-2-amino-3-[4-(3'-deoxyribonucleic acid phosphonoxy)phenyl]propanoic acid" EXACT RESID-systematic []
synonym: "ACT_SITE O-(3'-phospho-DNA)-tyrosine intermediate" EXACT UniProt-feature []
synonym: "O4'-(phospho-3'-DNA)-L-tyrosine" EXACT RESID-name []
synonym: "O4'-L-tyrosine 3'-DNA phosphodiester" EXACT RESID-alternate []
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00750 ! deoxyribonucleic acid linked residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00329
name: hydroxyheme-L-glutamate ester
def: "A protein modification that effectively results from forming an adduct between a glutamic acid residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:11139583, PubMed:11821421, PubMed:11980497, RESID:AA0324, Unimod:436#E]
synonym: "5-hydroxymethyl protoporphyrin IX 5-glutamate ester" EXACT RESID-alternate []
synonym: "[3-[(S)-(4-amino-4-carboxy)butanoyloxymethyl]-7,12-diethenyl-8,13,17-trimethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic []
synonym: "BINDING Heme (covalent; via 1 link)" EXACT UniProt-feature []
synonym: "cytochrome P450 CYP4A family heme cofactor" EXACT RESID-alternate []
synonym: "Hydroxyheme" RELATED PSI-MS-label []
synonym: "hydroxyheme" RELATED Unimod-description []
synonym: "hydroxyheme-L-glutamate ester" EXACT RESID-name []
xref: DiffAvg: "614.48"
xref: DiffFormula: "C 34 Fe 1 H 30 N 4 O 4"
xref: DiffMono: "614.161643"
xref: Formula: "C 39 Fe 1 H 37 N 5 O 7"
xref: MassAvg: "743.60"
xref: MassMono: "743.204236"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:436"
is_a: MOD:00699 ! porphyrin modified residue
is_a: MOD:02068 ! metal or metal cluster coordinated L-glutamic acid residue

[Term]
id: MOD:00330
name: (phospho-5'-guanosine)-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to a (phospho-5'-guanosine)-L-histidine." [PubMed:10529169, PubMed:10869342, PubMed:7559521, RESID:AA0325, Unimod:413#H]
synonym: "(2S)-2-amino-3-(1-(5'-adenosine phosphono)imidazol-4-yl)propanoic acid" EXACT RESID-systematic []
synonym: "1'-(phospho-5'-guanosine)-L-histidine" EXACT RESID-name []
synonym: "ACT_SITE GMP-histidine intermediate" EXACT UniProt-feature []
synonym: "L-histidine 5'-guanosine phosphoramidester" EXACT RESID-alternate []
synonym: "L-histidine monoanhydride with 5'-guanylic acid" EXACT RESID-alternate []
synonym: "N(tau)-5'-guanylic-L-histidine" EXACT RESID-alternate []
synonym: "N1'-guanylylated histidine" EXACT RESID-alternate []
synonym: "phospho-guanosine" RELATED Unimod-description []
synonym: "Phosphoguanosine" RELATED PSI-MS-label []
synonym: "tele-5'-guanylic-L-histidine" EXACT RESID-alternate []
xref: DiffAvg: "345.21"
xref: DiffFormula: "C 10 H 12 N 5 O 7 P 1"
xref: DiffMono: "345.047434"
xref: Formula: "C 16 H 19 N 8 O 8 P 1"
xref: MassAvg: "482.35"
xref: MassMono: "482.106346"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:413"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01163 ! guanylated residue

[Term]
id: MOD:00331
name: tetrakis-L-cysteinyl triiron tetrasulfide
def: "A protein modification that effectively converts four L-cysteine residues and a three-iron four-sulfur cluster to tetrakis-L-cysteinyl triiron tetrasulfide." [PubMed:11592901, PubMed:11941493, PubMed:2511202, PubMed:6094558, RESID:AA0326]
comment: Cross-link 4.
synonym: "bis[bis-L-cysteinyl iron disulfido]iron" EXACT RESID-alternate []
synonym: "di-mu-1:2kappaS-sulfido di-mu-2:3kappaS-sulfido iron bis(bis-S-cysteinyliron)" EXACT RESID-systematic []
synonym: "tetra-mu-sulfido tetrakis-S-L-cysteinyl triiron" EXACT RESID-alternate []
synonym: "tetrakis-L-cysteinyl linear [3Fe-4S] cluster" EXACT RESID-alternate []
synonym: "tetrakis-L-cysteinyl triiron tetrasulfide" EXACT RESID-name []
synonym: "tetrakis-L-cysteinyl triiron tetrasulfide D2 cluster" EXACT RESID-alternate []
xref: DiffAvg: "291.74"
xref: DiffFormula: "C 0 Fe 3 H -4 N 0 O 0 S 4"
xref: DiffMono: "291.663442"
xref: FormalCharge: "3-"
xref: Formula: "C 12 Fe 3 H 16 N 4 O 4 S 8"
xref: MassAvg: "704.30"
xref: MassMono: "703.700181"
xref: Origin: "C, C, C, C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00332
name: omega-N-glucosyl-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to N4-glucosyl-arginine." [PubMed:15279557, PubMed:8521968, PubMed:9536051, RESID:AA0327, Unimod:41#R]
synonym: "(2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid" EXACT RESID-systematic []
synonym: "Hex" RELATED PSI-MS-label []
synonym: "Hexose" RELATED Unimod-description []
synonym: "NG-beta-D-glucosylarginine" EXACT RESID-alternate []
synonym: "omega-N-(beta-D-glucosyl)-L-arginine" EXACT RESID-alternate []
synonym: "omega-N-glucosyl-L-arginine" EXACT RESID-name []
synonym: "omega-N-glycosyl-L-arginine" EXACT RESID-alternate []
synonym: "CARBOHYD N-linked (Glc) arginine" EXACT UniProt-feature []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 12 H 22 N 4 O 6"
xref: MassAvg: "318.33"
xref: MassMono: "318.153934"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:41"
xref: uniprot.ptm:PTM-0515
is_a: MOD:00433 ! monoglucosylated residue
is_a: MOD:01980 ! omega-N-glycosyl-L-arginine

[Term]
id: MOD:00333
name: (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine
def: "A protein modification that effectively converts an L-asparagine residue to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine." [PubMed:7559516, PubMed:7835418, PubMed:8183363, RESID:AA0328, Unimod:437#C-term]
comment: Unimod origin shown as C-term [JSG].
synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine" EXACT RESID-name []
synonym: "(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5-adenosine" RELATED Unimod-description []
synonym: "5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]adenosine" EXACT RESID-systematic []
synonym: "9-(5'-O-[(3-aminopropoxy)(L-aspart-1-ylamino)phosphoryl]-beta-D-ribofuranosyl)adenine" EXACT RESID-alternate []
synonym: "C-Asn-deriv" RELATED Unimod-interim []
synonym: "microcin C7 asparagine modification" EXACT RESID-alternate []
synonym: "MOD_RES Aspartic acid 1-[(3-aminopropyl)(5'-adenosyl)phosphono]amide" EXACT UniProt-feature []
synonym: "N-(aspart-1-yl)-O-(3-aminopropyl)-O-(5'-adenosyl)phosphoramide" EXACT RESID-alternate []
xref: DiffAvg: "386.30"
xref: DiffFormula: "C 13 H 19 N 6 O 6 P 1"
xref: DiffMono: "386.110369"
xref: Formula: "C 17 H 26 N 8 O 9 P 1"
xref: MassAvg: "517.42"
xref: MassMono: "517.156036"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:437"
xref: uniprot.ptm:PTM-0335
is_a: MOD:00701 ! nucleotide or nucleic acid modified residue
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:00334
name: 1'-heme-L-histidine
def: "A protein modification that effectively results from forming an adduct between the tele nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron." [PubMed:12033922, PubMed:12121092, RESID:AA0329, Unimod:390#H]
synonym: "(S)-[7-ethenyl-12-[1-((2-amino-2-carboxyethyl)-1H-imidazol-1-yl)ethyl]-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-bis(2-carboxyethyl)-N21,N22,N23,N24]-ferrate" EXACT RESID-systematic []
synonym: "1'-heme-L-histidine" EXACT RESID-name []
synonym: "2-[1-(N1'-histidyl)ethyl]protoporphyrin IX" EXACT RESID-alternate []
synonym: "BINDING Heme (covalent; via tele nitrogen)" EXACT UniProt-feature []
synonym: "Heme" RELATED PSI-MS-label []
synonym: "heme" RELATED Unimod-description []
synonym: "N(epsilon)-histidyl heme" EXACT RESID-alternate []
synonym: "N(tau)-histidyl heme" EXACT RESID-alternate []
synonym: "N1'-histidyl heme" EXACT RESID-alternate []
synonym: "tele-histidyl heme" EXACT RESID-alternate []
xref: DiffAvg: "616.50"
xref: DiffFormula: "C 34 Fe 1 H 32 N 4 O 4"
xref: DiffMono: "616.177293"
xref: Formula: "C 40 Fe 1 H 39 N 7 O 5"
xref: MassAvg: "753.64"
xref: MassMono: "753.236205"
xref: Origin: "H"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:390"
is_a: MOD:00699 ! porphyrin modified residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00335
name: (2S,3S,2'R)-3-methyllanthionine sulfoxide
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine sulfoxide." [PubMed:7737178, PubMed:9219543, RESID:AA0330]
comment: Cross-link 2.
synonym: "(2S,3S,4Xi,6R)-2,6-diamino-3-methyl-4-oxo-4-thiaheptanedioic acid" EXACT RESID-alternate []
synonym: "(2S,3S,SXi)-2-amino-3-([(R)-2-amino-2-carboxyethyl]sulfinyl)butanoic acid" EXACT RESID-systematic []
synonym: "3-methyl-L-lanthionine S-oxide" EXACT RESID-alternate []
synonym: "3-methyl-L-lanthionine sulfoxide" EXACT RESID-name []
synonym: "CROSSLNK Beta-methyllanthionine sulfoxide (Thr-Cys)" EXACT UniProt-feature []
synonym: "S-oxy-3-methyllanthionine" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 7 H 10 N 2 O 3 S 1"
xref: MassAvg: "202.23"
xref: MassMono: "202.041213"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0069
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:01993 ! beta-carbon thioether crosslinked residues
relationship: has_functional_parent MOD:01981 ! 3-methyllanthionine

[Term]
id: MOD:00336
name: tris-L-cysteinyl L-aspartato diiron disulfide
def: "A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-aspartato diiron disulfide." [PubMed:10968624, PubMed:1312028, PubMed:7947772, RESID:AA0331]
comment: Cross-link 4.
synonym: "di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-O4-aspartatoiron)" EXACT RESID-systematic []
synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature []
synonym: "tris-L-cysteinyl L-aspartato diiron disulfide" EXACT RESID-name []
xref: DiffAvg: "171.78"
xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2"
xref: DiffMono: "171.783814"
xref: FormalCharge: "2-"
xref: Formula: "C 13 Fe 2 H 16 N 4 O 6 S 5"
xref: MassAvg: "596.28"
xref: MassMono: "595.838311"
xref: Origin: "C, C, C, D"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02066 ! metal or metal cluster coordinated L-aspartic acid residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00337
name: S-carbamoyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-carbamoyl-L-cysteine." [PubMed:12586941, PubMed:240389, RESID:AA0332, Unimod:5#C]
synonym: "(R)-2-amino-3-(carbamoylsulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(aminocarbonyl)sulfanylpropanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-(aminocarbonyl)thiopropanoic acid" EXACT RESID-alternate []
synonym: "alpha-amino-beta-carbamylthiopropionic acid" EXACT RESID-alternate []
synonym: "beta-carbamylthioalanine" EXACT RESID-alternate []
synonym: "MOD_RES S-carbamoylcysteine" EXACT UniProt-feature []
synonym: "S-(aminocarbonyl)cysteine" EXACT RESID-alternate []
synonym: "S-carbamoyl-L-cysteine" EXACT RESID-name []
synonym: "S-carbamoylcysteine" EXACT RESID-alternate []
synonym: "S-carbamylcysteine" EXACT RESID-alternate []
synonym: "S-cysteinyl carbamate ester" EXACT RESID-alternate []
synonym: "SCbmCys" EXACT PSI-MOD-label []
xref: DiffAvg: "43.02"
xref: DiffFormula: "C 1 H 1 N 1 O 1 S 0"
xref: DiffMono: "43.005814"
xref: Formula: "C 4 H 6 N 2 O 2 S 1"
xref: MassAvg: "146.16"
xref: MassMono: "146.014998"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:5"
xref: uniprot.ptm:PTM-0649
is_a: MOD:00398 ! carbamoylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00338
name: S-cyano-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-cyano-L-cysteine." [PubMed:12586941, PubMed:4808702, RESID:AA0333, Unimod:438#C]
synonym: "(2R)-2-amino-3-thiocyanatopropanoic acid" EXACT RESID-systematic []
synonym: "alpha-amino-beta-thiocyanatopropionic acid" EXACT RESID-alternate []
synonym: "beta-thiocyanatoalanine" EXACT RESID-alternate []
synonym: "Cyano" RELATED PSI-MS-label []
synonym: "cyano" RELATED Unimod-description []
synonym: "MOD_RES S-cyanocysteine" EXACT UniProt-feature []
synonym: "S-cyano-L-cysteine" EXACT RESID-name []
synonym: "S-cyanocysteine" EXACT RESID-alternate []
synonym: "serine thiocyanic acid ester" EXACT RESID-alternate []
xref: DiffAvg: "25.01"
xref: DiffFormula: "C 1 H -1 N 1 O 0 S 0"
xref: DiffMono: "24.995249"
xref: Formula: "C 4 H 4 N 2 O 1 S 1"
xref: MassAvg: "128.15"
xref: MassMono: "128.004434"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:438"
xref: uniprot.ptm:PTM-0650
is_a: MOD:00893 ! residues isobaric at 128.0-128.1
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00339
name: L-cysteinyl hydrogenase diiron subcluster
def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl hydrogenase diiron subcluster." [PubMed:10694885, PubMed:9836629, RESID:AA0334, Unimod:439#C]
comment: incidental to RESID:AA0140.
synonym: "1,7-biscarbonyl-1-(cystein-S-yl)-8-oxo-4-aza-2lambda(3),6 lambda(3)-dithia-1,7-diferratricyclo[4.2.0.0(2,7)]octane-1,7-dicarbonitrile" EXACT RESID-alternate []
synonym: "Diironsubcluster" RELATED PSI-MS-label []
synonym: "hydrogenase diiron subcluster" RELATED Unimod-description []
synonym: "L-cysteinyl hydrogenase diiron subcluster" EXACT RESID-name []
synonym: "METAL Diiron subcluster" EXACT UniProt-feature []
synonym: "mu-carbonyl-dicarbonyl-1kappaC,2kappaC-dicyanido-1kappaC,2kappaC-cysteinato-1kS-1,2-azadimethanthiol-1kS,2kS'-diiron" EXACT RESID-systematic []
xref: DiffAvg: "342.87"
xref: DiffFormula: "C 5 Fe 2 H -1 N 2 O 5 S 2"
xref: DiffMono: "342.786913"
xref: Formula: "C 8 Fe 2 H 4 N 3 O 6 S 3"
xref: MassAvg: "446.01"
xref: MassMono: "445.796098"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:439"
is_a: MOD:00738 ! iron containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00340
name: S-amidino-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-amidino-L-cysteine." [PubMed:9148748, RESID:AA0335, Unimod:440#C]
synonym: "(2R)-2-amino-3-(carbamimidoylsulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-amidinosulfanylpropanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-amidinothiopropanoic acid" EXACT RESID-alternate []
synonym: "ACT_SITE Amidino-cysteine intermediate" EXACT UniProt-feature []
synonym: "alpha-amino-beta-amidinothiopropionic acid" EXACT RESID-alternate []
synonym: "Amidino" RELATED PSI-MS-label []
synonym: "amidino" RELATED Unimod-description []
synonym: "beta-(S-isothiourea)alanine" EXACT RESID-alternate []
synonym: "beta-amidinothioalanine" EXACT RESID-alternate []
synonym: "S-amidino-L-cysteine" EXACT RESID-name []
synonym: "S-amidinocysteine" EXACT RESID-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 1 H 2 N 2 O 0 S 0"
xref: DiffMono: "42.021798"
xref: Formula: "C 4 H 7 N 3 O 1 S 1"
xref: MassAvg: "145.18"
xref: MassMono: "145.030983"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:440"
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00341
name: N-methyl-L-isoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to N-methyl-L-isoleucine." [PubMed:11875433, RESID:AA0336]
comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].
synonym: "(2S,3S)-2-methylamino-3-methylpentanoic acid" EXACT RESID-systematic []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES N-methylisoleucine" EXACT UniProt-feature []
synonym: "N-methyl-L-isoleucine" EXACT RESID-name []
synonym: "N-methylated L-isoleucine" EXACT PSI-MOD-alternate []
synonym: "N-methylisoleucine" EXACT RESID-alternate []
synonym: "NMe1Ile" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 13 N 1 O 1"
xref: MassAvg: "127.19"
xref: MassMono: "127.099714"
xref: Origin: "I"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0215
is_a: MOD:00715 ! methylated isoleucine
is_a: MOD:01680 ! alpha-amino monomethylated residue

[Term]
id: MOD:00342
name: N-methyl-L-leucine
def: "A protein modification that effectively converts an L-leucine residue to N-methyl-L-leucine." [PubMed:11875433, RESID:AA0337]
comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].
synonym: "(S)-2-methylamino-4-methylpentanoic acid" EXACT RESID-systematic []
synonym: "2-(methylamino)-4-methyl-valeric acid" EXACT RESID-alternate []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "MOD_RES N-methylleucine" EXACT UniProt-feature []
synonym: "N-methyl-L-leucine" EXACT RESID-name []
synonym: "N-methylated L-leucine" EXACT PSI-MOD-alternate []
synonym: "N-methylleucine" EXACT RESID-alternate []
synonym: "NMe1Leu" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 13 N 1 O 1"
xref: MassAvg: "127.19"
xref: MassMono: "127.099714"
xref: Origin: "L"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0216
is_a: MOD:01680 ! alpha-amino monomethylated residue
is_a: MOD:01808 ! N-methylated leucine

[Term]
id: MOD:00343
name: N-methyl-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to N-methyl-L-tyrosine." [DeltaMass:0, RESID:AA0338]
comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].
synonym: "(2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid" EXACT RESID-systematic []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "MOD_RES N-methyltyrosine" EXACT UniProt-feature []
synonym: "N-methyl Tyrosinyl" EXACT DeltaMass-label []
synonym: "N-methyl-L-tyrosine" EXACT RESID-name []
synonym: "N-methylated L-tyrosine" EXACT PSI-MOD-alternate []
synonym: "N-methyltyrosine" EXACT RESID-alternate []
synonym: "NMe1Tyr" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 10 H 11 N 1 O 2"
xref: MassAvg: "177.20"
xref: MassMono: "177.078979"
xref: Origin: "Y"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0220
is_a: MOD:00718 ! methylated tyrosine
is_a: MOD:01680 ! alpha-amino monomethylated residue

[Term]
id: MOD:00344
name: N-palmitoylglycine
def: "A protein modification that effectively converts a glycine residue to N-palmitoylglycine." [PubMed:12574119, RESID:AA0339]
comment: incidental to RESID:AA0060
subset: PSI-MOD-slim
synonym: "(hexadecanamido)acetic acid" EXACT RESID-alternate []
synonym: "(hexadecanoylamino)acetic acid" EXACT RESID-alternate []
synonym: "(hexadecanoylamino)ethanoic acid" EXACT RESID-systematic []
synonym: "LIPID N-palmitoyl glycine" EXACT UniProt-feature []
synonym: "N-(1-oxohexadecyl)glycine" EXACT RESID-alternate []
synonym: "N-palmitoyl-glycine" EXACT RESID-name []
synonym: "N-palmitoylated glycine" EXACT PSI-MOD-alternate []
synonym: "N-hexadecanoylated glycine" EXACT PSI-MOD-alternate []
synonym: "NPamGly" EXACT PSI-MOD-label []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0"
xref: DiffMono: "238.229666"
xref: Formula: "C 18 H 34 N 1 O 2"
xref: MassAvg: "296.47"
xref: MassMono: "296.258954"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0223
is_a: MOD:00908 ! modified glycine residue
is_a: MOD:01685 ! alpha-amino palmitoylated residue

[Term]
id: MOD:00345
name: 2-(S-L-cysteinyl)-L-phenylalanine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-phenylalanine." [PubMed:12696888, PubMed:3936839, RESID:AA0340]
comment: Cross-link 2.
synonym: "(2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid" EXACT RESID-systematic []
synonym: "(2R,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid" EXACT RESID-alternate []
synonym: "2-(L-cystein-S-yl)-L-phenylalanine" EXACT RESID-name []
synonym: "alpha-(L-cystein-S-yl)-L-phenylalanine" EXACT RESID-alternate []
synonym: "CROSSLNK 2-cysteinyl-L-phenylalanine (Cys-Phe)" EXACT UniProt-feature []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 12 H 12 N 2 O 2 S 1"
xref: MassAvg: "248.30"
xref: MassMono: "248.061949"
xref: Origin: "C, F"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0012
is_a: MOD:02053 ! crosslinked L-phenylalanine residue
is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues

[Term]
id: MOD:00346
name: 2-(S-L-cysteinyl)-D-phenylalanine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-phenylalanine." [PubMed:12696888, PubMed:3936839, RESID:AA0341]
comment: Cross-link 2.
synonym: "(2S)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-phenylpropanoic acid" EXACT RESID-systematic []
synonym: "(2S,5R)-2,5-diamino-3-thia-2-phenylmethylhexanedioic acid" EXACT RESID-alternate []
synonym: "2-(L-cystein-S-yl)-D-phenylalanine" EXACT RESID-name []
synonym: "alpha-(L-cystein-S-yl)-D-phenylalanine" EXACT RESID-alternate []
synonym: "CROSSLNK 2-cysteinyl-D-phenylalanine (Cys-Phe)" EXACT UniProt-feature []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 12 H 12 N 2 O 2 S 1"
xref: MassAvg: "248.30"
xref: MassMono: "248.061949"
xref: Origin: "C, F"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0011
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:02053 ! crosslinked L-phenylalanine residue
is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues

[Term]
id: MOD:00347
name: 2-(S-L-cysteinyl)-D-allo-threonine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-allo-threonine." [PubMed:12696888, PubMed:3936839, RESID:AA0342]
comment: Cross-link 2.
synonym: "(2R,5S,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid" EXACT RESID-alternate []
synonym: "(2S,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid" EXACT RESID-systematic []
synonym: "2-(L-cystein-S-yl)-D-allo-threonine" EXACT RESID-name []
synonym: "alpha-(L-cystein-S-yl)-D-allo-threonine" EXACT RESID-alternate []
synonym: "CROSSLNK 2-cysteinyl-D-allo-threonine (Cys-Thr)" EXACT UniProt-feature []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 7 H 10 N 2 O 3 S 1"
xref: MassAvg: "202.23"
xref: MassMono: "202.041213"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0010
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues

[Term]
id: MOD:00348
name: N-carbamoyl-L-alanine
def: "A protein modification that effectively converts an L-alanine residue to N-carbamoyl-L-alanine." [PubMed:12203680, RESID:AA0343]
synonym: "(S)-2-(carbamoylamino)propanoic acid" EXACT RESID-systematic []
synonym: "2-ureidopropanoic acid" EXACT RESID-alternate []
synonym: "MOD_RES N-carbamoylalanine" EXACT UniProt-feature []
synonym: "N-carbamoyl-L-alanine" EXACT RESID-name []
synonym: "N-carbamylalanine" EXACT RESID-alternate []
synonym: "N2CbmAla" EXACT PSI-MOD-label []
xref: DiffAvg: "43.02"
xref: DiffFormula: "C 1 H 1 N 1 O 1"
xref: DiffMono: "43.005814"
xref: Formula: "C 4 H 7 N 2 O 2"
xref: MassAvg: "115.11"
xref: MassMono: "115.050752"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0374
is_a: MOD:00901 ! modified L-alanine residue
is_a: MOD:01679 ! alpha-aminocarbamoylated residue

[Term]
id: MOD:00349
name: 4-amino-3-isothiazolidinone-L-serine
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form 4-amino-3-isothiazolidinone-L-serine." [PubMed:12802338, PubMed:12802339, RESID:AA0344]
comment: Cross-link 2.
synonym: "(2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-hydroxypropanoic acid" EXACT RESID-systematic []
synonym: "2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-hydroxy-propanoic acid" EXACT RESID-alternate []
synonym: "4-amino-3-isothiazolidinone-L-serine" EXACT RESID-alternate []
synonym: "CROSSLNK N,N-(cysteine-1,S-diyl)serine (Cys-Ser)" EXACT UniProt-feature []
synonym: "N,N-(L-cysteine-1,S-diyl)-L-serine" EXACT RESID-name []
synonym: "serine-cysteine sulfenyl amide cross-link" EXACT RESID-alternate []
synonym: "serine-cysteine sulphenyl amide cross-link" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 6 H 8 N 2 O 3 S 1"
xref: MassAvg: "188.20"
xref: MassMono: "188.025563"
xref: Origin: "C, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0037
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01861 ! isothiazolidinone ring crosslinked residues

[Term]
id: MOD:00350
name: L-threonyl-pentaglycyl-murein peptidoglycan
def: "A protein modification that effectively attaches an L-threonine residue to murein peptidoglycan by a pentaglycine linker peptide." [PubMed:10754567, PubMed:1638631, RESID:AA0345]
synonym: "(2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(threonyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine" EXACT RESID-alternate []
synonym: "L-threonyl-pentaglycyl-murein peptidoglycan" EXACT RESID-name []
synonym: "MOD_RES Pentaglycyl murein peptidoglycan amidated threonine" EXACT UniProt-feature []
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0246
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:01159 ! peptidoglycanated residue

[Term]
id: MOD:00351
name: N-glycyl-1-(phosphatidyl)ethanolamine
def: "A protein modification that effectively converts a glycine residue to N-glycyl-1-(phosphatidyl)ethanolamine." [PubMed:11100732, RESID:AA0346]
synonym: "(R)-1-hexadecanoyloxy-2-((Z)-9-octadecenoyloxy)-3-[2-(aminoacetylamino)ethyloxyphospho]propane" EXACT RESID-systematic []
synonym: "LIPID Phosphatidylethanolamine amidated glycine" EXACT UniProt-feature []
synonym: "N-glycyl-1-(phosphatidyl)ethanolamine" EXACT RESID-name []
synonym: "N-glycyl-1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine" EXACT RESID-alternate []
xref: DiffAvg: "699.99"
xref: DiffFormula: "C 39 H 74 N 1 O 7 P 1"
xref: DiffMono: "699.520290"
xref: Formula: "C 41 H 78 N 2 O 9 P 1"
xref: MassAvg: "774.05"
xref: MassMono: "773.544494"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0249
is_a: MOD:00908 ! modified glycine residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00352
name: L-glutamyl 5-omega-hydroxyceramide ester
def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-omega-hydroxyceramide ester." [PubMed:10411887, PubMed:9651377, RESID:AA0347]
synonym: "(S)-2-amino-5-[30-((2S,3R,4E)-1,3-dihydroxyicos-4-en-2-ylamino)-30-oxotriacontan-1-yloxy]-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "2-[30-(isoglutamyloxy)triacontanoyl]icosasphingosine" EXACT RESID-alternate []
synonym: "L-glutamyl 5-omega-hydroxyceramide ester" EXACT RESID-name []
synonym: "LIPID Omega-hydroxyceramide glutamate ester" EXACT UniProt-feature []
xref: DiffAvg: "761.31"
xref: DiffFormula: "C 50 H 96 N 0 O 4"
xref: DiffMono: "760.730862"
xref: Formula: "C 55 H 104 N 2 O 6"
xref: MassAvg: "889.44"
xref: MassMono: "888.789439"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0236
is_a: MOD:00907 ! modified L-glutamine residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00353
name: S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium
def: "A protein modification that effectively cross-links an L-tryptophan residue with an L-tyrosine residue by a carbon-carbon bond, and cross-links the L-tyrosine residue to an L-methionine residue by a thioether bond to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium." [PubMed:12172540, PubMed:16285713, RESID:AA0348]
comment: Cross-link 3.
synonym: "5'-(6'-tryptophyl)-tyrosin-3'-yl-methionin-S-ium" EXACT RESID-alternate []
synonym: "S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium" EXACT RESID-name []
xref: DiffAvg: "-3.02"
xref: DiffFormula: "C 0 H -3 N 0 O 0 S 0"
xref: DiffMono: "-3.024024"
xref: FormalCharge: "1+"
xref: Formula: "C 25 H 25 N 4 O 4 S 1"
xref: MassAvg: "477.56"
xref: MassMono: "477.159103"
xref: Origin: "M, W, Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0328
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02052 ! crosslinked L-methionine residue
is_a: MOD:02057 ! crosslinked L-tryptophan residue
is_a: MOD:02058 ! crosslinked L-tyrosine residue

[Term]
id: MOD:00354
name: O-(riboflavin phosphoryl)-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-(riboflavin phosphoryl)-L-threonine." [PubMed:10587447, PubMed:11163785, PubMed:11248234, RESID:AA0349, Unimod:442#T]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)butanoic acid" EXACT RESID-systematic []
synonym: "FMN" RELATED PSI-MS-label []
synonym: "MOD_RES FMN phosphoryl threonine" EXACT UniProt-feature []
synonym: "O-(riboflavin phosphoryl)-L-threonine" EXACT RESID-name []
synonym: "O3-(riboflavin phosphoryl)" RELATED Unimod-description []
synonym: "O3-threonyl flavin mononucleotide" EXACT RESID-alternate []
synonym: "O3-threonyl FMN" EXACT RESID-alternate []
synonym: "OFMNThr" EXACT PSI-MOD-label []
xref: DiffAvg: "438.33"
xref: DiffFormula: "C 17 H 19 N 4 O 8 P 1"
xref: DiffMono: "438.094050"
xref: Formula: "C 21 H 26 N 5 O 10 P 1"
xref: MassAvg: "539.44"
xref: MassMono: "539.141729"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:442"
xref: uniprot.ptm:PTM-0126
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:01164 ! riboflavin-phosphorylated residue

[Term]
id: MOD:00355
name: O-(riboflavin phosphoryl)-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-(riboflavin phosphoryl)-L-serine." [RESID:AA0350, Unimod:442#S]
subset: PSI-MOD-slim
synonym: "(R)-2-amino-3-(riboflavin 5'-hydrogen phosphonoxy)propanoic acid" EXACT RESID-systematic []
synonym: "FMN" RELATED PSI-MS-label []
synonym: "MOD_RES FMN phosphoryl serine" EXACT UniProt-feature []
synonym: "O-(riboflavin phosphoryl)-L-serine" EXACT RESID-name []
synonym: "O3-(riboflavin phosphoryl)" RELATED Unimod-description []
synonym: "O3-seryl flavin mononucleotide" EXACT RESID-alternate []
synonym: "O3-seryl FMN" EXACT RESID-alternate []
synonym: "OFMNSer" EXACT PSI-MOD-label []
xref: DiffAvg: "438.33"
xref: DiffFormula: "C 17 H 19 N 4 O 8 P 1"
xref: DiffMono: "438.094050"
xref: Formula: "C 20 H 24 N 5 O 10 P 1"
xref: MassAvg: "525.41"
xref: MassMono: "525.126079"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:442"
xref: uniprot.ptm:PTM-0125
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01164 ! riboflavin-phosphorylated residue

[Term]
id: MOD:00356
name: S-(4alpha-FMN)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(4a-FMN)-L-cysteine." [PubMed:12668455, PubMed:12846567, PubMed:7692961, RESID:AA0351, Unimod:443#C]
subset: PSI-MOD-slim
synonym: "(R)-2-amino-3-(4a-riboflavin 5'-dihydrogen phosphate)sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "4a-(S-cysteinyl)flavin mononucleotide" EXACT RESID-alternate []
synonym: "4a-(S-cysteinyl)FMN" EXACT RESID-alternate []
synonym: "FMNC" RELATED PSI-MS-label []
synonym: "MOD_RES S-4a-FMN cysteine" EXACT UniProt-feature []
synonym: "S-(4a-FMN)" RELATED Unimod-description []
synonym: "S-(4a-FMN)-L-cysteine" EXACT RESID-name []
synonym: "S4aFMNCys" EXACT PSI-MOD-label []
xref: DiffAvg: "456.35"
xref: DiffFormula: "C 17 H 21 N 4 O 9 P 1 S 0"
xref: DiffMono: "456.104615"
xref: Formula: "C 20 H 26 N 5 O 10 P 1 S 1"
xref: MassAvg: "559.49"
xref: MassMono: "559.113800"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:443"
xref: uniprot.ptm:PTM-0270
is_a: MOD:02083 ! 4alpha-FMN modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00357
name: 1'-(8alpha-FMN)-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FMN)-L-histidine." [PubMed:11902668, PubMed:8611516, RESID:AA0352, Unimod:409#H]
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-(1-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid" EXACT RESID-systematic []
synonym: "1'-(8alpha-FMN)-L-histidine" EXACT RESID-name []
synonym: "8alpha-(N(epsilon)-histidyl)FMN" EXACT RESID-alternate []
synonym: "8alpha-(N1'-histidyl)FMN" EXACT RESID-alternate []
synonym: "flavin mononucleotide" RELATED Unimod-description []
synonym: "FMNH" RELATED PSI-MS-label []
synonym: "MOD_RES Tele-8alpha-FMN histidine" EXACT UniProt-feature []
synonym: "N(tau)-(8alpha-FMN)-histidine" EXACT RESID-alternate []
synonym: "Ntele8aFMNHis" EXACT PSI-MOD-label []
synonym: "tele-(8alpha-FMN)-histidine" EXACT RESID-alternate []
xref: DiffAvg: "454.33"
xref: DiffFormula: "C 17 H 19 N 4 O 9 P 1"
xref: DiffMono: "454.088965"
xref: Formula: "C 23 H 26 N 7 O 10 P 1"
xref: MassAvg: "591.47"
xref: MassMono: "591.147877"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:409"
xref: uniprot.ptm:PTM-0289
is_a: MOD:02085 ! 8alpha-FMN modified residue
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:00358
name: 3'-(8alpha-FMN)-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FMN)-L-histidine." [PubMed:12417325, RESID:AA0353, Unimod:409#H]
comment: In a later publication, PubMed:19438211, the authors changed the enzyme activity, the connection from a histidine nitrogen to a cysteine sulfur, and the identity of the flavin from FMN to FAD. They now believe the modification is S-(8alpha-FAD)-L-cysteine, see MOD:00152. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-(3-[8alpha riboflavin 5'-dihydrogen phosphate]imidazol-4-yl)propanoic acid" EXACT RESID-systematic []
synonym: "3'-(8alpha-FMN)-L-histidine" EXACT RESID-name []
synonym: "8alpha-(N(delta)-histidyl)FMN" EXACT RESID-alternate []
synonym: "8alpha-(N3'-histidyl)FMN" EXACT RESID-alternate []
synonym: "flavin mononucleotide" RELATED Unimod-description []
synonym: "FMNH" RELATED PSI-MS-label []
synonym: "N(pi)-(8alpha-FMN)-histidine" EXACT RESID-alternate []
synonym: "Npros8aFMNHis" EXACT PSI-MOD-label []
synonym: "pros-(8alpha-FMN)-histidine" EXACT RESID-alternate []
xref: DiffAvg: "454.33"
xref: DiffFormula: "C 17 H 19 N 4 O 9 P 1"
xref: DiffMono: "454.088965"
xref: Formula: "C 23 H 26 N 7 O 10 P 1"
xref: MassAvg: "591.47"
xref: MassMono: "591.147877"
xref: Origin: "H"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:409"
is_a: MOD:02085 ! 8alpha-FMN modified residue
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:00359
name: N2-acetyl-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to N2-acetyl-L-arginine." [PubMed:12883043, PubMed:1894641, RESID:AA0354]
synonym: "(S)-2-acetamido-5-carbamimidamidopentanoic acid" EXACT RESID-systematic []
synonym: "2-acetamido-5-guanidinopentanoic acid" EXACT RESID-alternate []
synonym: "2-acetylamino-5-guanidinopentanoic acid" EXACT RESID-alternate []
synonym: "AcArg" EXACT PSI-MOD-label []
synonym: "acetylarginine" EXACT RESID-alternate []
synonym: "alpha-acetylamino-delta-guanidinovaleric acid" EXACT RESID-alternate []
synonym: "MOD_RES N2-acetylarginine" EXACT UniProt-feature []
synonym: "N(alpha)-acetylarginine" EXACT RESID-alternate []
synonym: "N2-acetyl-L-arginine" EXACT RESID-name []
synonym: "N2-acetylated L-arginine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 8 H 15 N 4 O 2"
xref: MassAvg: "199.23"
xref: MassMono: "199.119501"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0180
is_a: MOD:00902 ! modified L-arginine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00360
name: L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide
def: "A protein modification that effectively converts an L-cysteine residue to L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide." [PubMed:12475995, RESID:AA0355, Unimod:444#C]
synonym: "[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with cytosine)methyl-6-oxo-3,4-dimercapto-pteridino[6,7-5,6]pyranoato-S3,S4]-cysteinyl-S-copper-mu-sulfido-molybdenum hydroxide oxide" EXACT RESID-systematic []
synonym: "copper sulfido molybdopterin cytosine dinuncleotide" RELATED Unimod-description []
synonym: "CuSMo" RELATED PSI-MS-label []
synonym: "cysteinyl copper mu-sulfido Mo-pterin cytosine dinucleotide" EXACT RESID-alternate []
synonym: "L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide" EXACT RESID-name []
xref: DiffAvg: "922.07"
xref: DiffFormula: "C 19 Cu 1 H 24 Mo 1 N 8 O 15 P 2 S 3"
xref: DiffMono: "922.834854"
xref: Formula: "C 22 Cu 1 H 29 Mo 1 N 9 O 16 P 2 S 4"
xref: MassAvg: "1025.20"
xref: MassMono: "1025.844039"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:444"
is_a: MOD:00742 ! copper containing modified residue
is_a: MOD:00744 ! molybdenum pterin containing modification
is_a: MOD:00860 ! sulfur containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00361
name: tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide
def: "A protein modification that effectively converts three L-cysteine residues, an S-adenosylmethionine and a four-iron four-sulfur cluster to tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide." [PubMed:11222759, PubMed:14704425, RESID:AA0356]
comment: Cross-link 3.
synonym: "METAL Iron-sulfur (4Fe-4S-S-AdoMet)" EXACT UniProt-feature []
synonym: "tetra-mu3-sulfido(S-adenosylmethion-N,O-diyliron)tris(S-cysteinyliron)" EXACT RESID-systematic []
synonym: "tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide" EXACT RESID-name []
xref: DiffAvg: "747.03"
xref: DiffFormula: "C 15 Fe 4 H 19 N 6 O 5 S 5"
xref: DiffMono: "746.742346"
xref: FormalCharge: "1-"
xref: Formula: "C 24 Fe 4 H 34 N 9 O 8 S 8"
xref: MassAvg: "1056.45"
xref: MassMono: "1055.769901"
xref: Origin: "C, C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00362
name: tris-L-cysteinyl L-arginyl diiron disulfide
def: "A protein modification that effectively converts three L-cysteine residues, an L-arginine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-arginyl diiron disulfide." [PubMed:14704425, RESID:AA0357]
comment: Cross-link 4.
synonym: "di-mu-sulfido(N(eta1)-arginyl-S-cysteinyliron)(bis-S-cysteinyliron)" EXACT RESID-systematic []
synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature []
synonym: "tris-L-cysteinyl L-arginyl diiron disulfide" EXACT RESID-name []
xref: DiffAvg: "172.79"
xref: DiffFormula: "C 0 Fe 2 H -3 N 0 O 0 S 2"
xref: DiffMono: "172.791639"
xref: FormalCharge: "2-"
xref: Formula: "C 15 Fe 2 H 24 N 7 O 4 S 5"
xref: MassAvg: "638.39"
xref: MassMono: "637.920304"
xref: Origin: "C, C, C, R"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02076 ! metal or metal cluster coordinated L-arginine residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:00363
name: L-cysteinyl-L-selenocysteine (Cys-Sec)
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-selenocysteine residues to form L-cysteinyl-L-selenocystine." [PubMed:12911312, RESID:AA0358#SEC]
comment: Cross-link 2.
subset: PSI-MOD-slim
synonym: "(R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Cysteinyl-selenocysteine (Cys-Sec)" EXACT UniProt-feature []
synonym: "CROSSLNK Cysteinyl-selenocysteine (Sec-Cys)" EXACT UniProt-feature []
synonym: "L-cysteinyl-L-selenocysteine" EXACT RESID-name []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0 Se 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 6 H 8 N 2 O 2 S 1 Se 1"
xref: MassAvg: "251.17"
xref: MassMono: "251.947170"
xref: Origin: "C, U"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0109
is_a: MOD:02061 ! crosslinked L-selenocysteine residue
is_a: MOD:01627 ! L-cysteinyl-L-selenocysteine

[Term]
id: MOD:00364
name: 5-hydroxy-N6,N6,N6-trimethyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 5-hydroxy-N6,N6,N6-trimethyl-L-lysine." [PubMed:11349130, PubMed:14661085, RESID:AA0359, Unimod:445#K]
comment: Incidental to RESID:AA0278; secondary to RESID:AA0028; secondary to RESID:AA0074.
synonym: "(2R,5Xi)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentan-1-aminium" EXACT RESID-systematic []
synonym: "(2Xi,5S)-5-amino-5-carboxy-2-hydroxy-N,N,N-trimethylpentanaminium" EXACT RESID-alternate []
synonym: "(2Xi,5S)-5-azanyl-5-carboxy-2-hydroxy-N,N,N-trimethylpentanazanium" EXACT RESID-alternate []
synonym: "5-hydroxy-N(zeta)-trimethyllysine" EXACT RESID-alternate []
synonym: "5-hydroxy-N6,N6,N6-trimethyl" RELATED Unimod-description []
synonym: "5-hydroxy-N6,N6,N6-trimethyl-L-lysine" EXACT RESID-name []
synonym: "5-hydroxy-N6,N6,N6-trimethyllysin-N6-ium" EXACT RESID-alternate []
synonym: "5-hydroxy-N6,N6,N6-trimethyllysine cation" EXACT RESID-alternate []
synonym: "5-hydroxylated N6,N6,N6-trimethylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "5HyN6Me3Lys" EXACT PSI-MOD-label []
synonym: "alpha-amino-epsilon-dimethylamino-delta-hydroxycaproic acid" EXACT RESID-alternate []
synonym: "delta-hydroxy-epsilon-N,N,N-trimethyllysine" EXACT RESID-alternate []
synonym: "Hydroxytrimethyl" RELATED PSI-MS-label []
synonym: "lysine derivative Lys(z)" EXACT RESID-alternate []
synonym: "MOD_RES N6,N6,N6-trimethyl-5-hydroxylysine" EXACT UniProt-feature []
xref: DiffAvg: "59.09"
xref: DiffFormula: "C 3 H 7 N 0 O 1"
xref: DiffMono: "59.049141"
xref: FormalCharge: "1+"
xref: Formula: "C 9 H 19 N 2 O 2"
xref: MassAvg: "187.26"
xref: MassMono: "187.144104"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:445"
xref: uniprot.ptm:PTM-0186
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:00912 ! modified L-lysine residue
relationship: has_functional_parent MOD:00037 ! 5-hydroxy-L-lysine
relationship: has_functional_parent MOD:00083 ! N6,N6,N6-trimethyl-L-lysine

[Term]
id: MOD:00365
name: N-(L-isoglutamyl)-glycine
def: "A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue by an isopeptide bond to form N-(L-isoglutamyl)-glycine." [PubMed:14531691, RESID:AA0360]
comment: Cross-link 2.
synonym: "(S)-2-amino-5-(carboxymethyl)amino-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "2-amino-N5-(carboxymethyl)-pentanediamic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Isoglutamyl glycine isopeptide (Gly-Glu)" EXACT UniProt-feature []
synonym: "isoglutamyl glycine" EXACT RESID-alternate []
synonym: "N-(L-isoglutamyl)-glycine" EXACT RESID-name []
synonym: "N-gamma-glutamylglycine" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 7 H 9 N 2 O 3"
xref: MassAvg: "169.16"
xref: MassMono: "169.061317"
xref: Origin: "E, G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0157
is_a: MOD:00688 ! isopeptide crosslinked residues
is_a: MOD:02045 ! crosslinked L-glutamic acid residue
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00366
name: O-sulfo-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-sulfo-L-serine." [PubMed:14752058, RESID:AA0361, Unimod:40#S]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(sulfooxy)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-hydroxypropanoic acid 3-sulfate" EXACT RESID-alternate []
synonym: "MOD_RES Sulfoserine" EXACT UniProt-feature []
synonym: "O-sulfo-L-serine" EXACT RESID-name []
synonym: "O-Sulfonation" RELATED Unimod-description []
synonym: "O3-sulfonoserine" EXACT RESID-alternate []
synonym: "O3-sulfoserine" EXACT RESID-alternate []
synonym: "serine sulfate ester" EXACT RESID-alternate []
synonym: "Sulfo" RELATED PSI-MS-label []
xref: DiffAvg: "80.06"
xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1"
xref: DiffMono: "79.956815"
xref: Formula: "C 3 H 5 N 1 O 5 S 1"
xref: MassAvg: "167.13"
xref: MassMono: "166.988843"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:40"
xref: uniprot.ptm:PTM-0284
is_a: MOD:00695 ! sulfated residue
is_a: MOD:00771 ! residues isobaric at 166.98-167.00 Da
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00367
name: O-sulfo-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-sulfo-L-threonine." [PubMed:14752058, RESID:AA0362, Unimod:40#T]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-(sulfooxy)butanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-hydroxybutanoic acid 3-sulfate" EXACT RESID-alternate []
synonym: "MOD_RES Sulfothreonine" EXACT UniProt-feature []
synonym: "O-sulfo-L-threonine" EXACT RESID-name []
synonym: "O-Sulfonation" RELATED Unimod-description []
synonym: "O3-sulfonothreonine" EXACT RESID-alternate []
synonym: "O3-sulfothreonine" EXACT RESID-alternate []
synonym: "Sulfo" RELATED PSI-MS-label []
synonym: "threonine sulfate ester" EXACT RESID-alternate []
xref: DiffAvg: "80.06"
xref: DiffFormula: "C 0 H 0 N 0 O 3 S 1"
xref: DiffMono: "79.956815"
xref: Formula: "C 4 H 7 N 1 O 5 S 1"
xref: MassAvg: "181.16"
xref: MassMono: "181.004493"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:40"
xref: uniprot.ptm:PTM-0285
is_a: MOD:00695 ! sulfated residue
is_a: MOD:00773 ! residues isobaric at 181.00-181.02 Da
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:00368
name: N-carboxy-L-methionine
def: "A protein modification that effectively converts an L-methionine residue to N-carboxy-L-methionine." [PubMed:10368287, PubMed:11120890, PubMed:12595263, PubMed:8312270, RESID:AA0363, Unimod:299#M]
comment: At least three protein crystallographic structures have been reported with this modification. However, no chemical evidence for this modification is provided, there were no reports of this modification before these crystallographic reports, and there is no metabolic explanation for the conversion of a formyl group to a carboxy group. There is confusion in its description, and misnaming is common. This modification is probably a misidentification of N-(dihydroxymethyl)methionine, the hydrated form of N-formylmethionine. See MOD:01446 [JSG].
synonym: "(S)-2-carboxyamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "2-carbamic-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate []
synonym: "2-carbamic-4-(methylthio)butanoic acid" EXACT RESID-alternate []
synonym: "Carboxy" RELATED Unimod-interim []
synonym: "Carboxylation" RELATED Unimod-description []
synonym: "N-carboxy-L-methionine" EXACT RESID-name []
synonym: "N-carboxymethionine" EXACT RESID-alternate []
xref: DiffAvg: "44.01"
xref: DiffFormula: "C 1 H 0 N 0 O 2 S 0"
xref: DiffMono: "43.989829"
xref: Formula: "C 6 H 10 N 1 O 3 S 1"
xref: MassAvg: "176.21"
xref: MassMono: "176.038139"
xref: Origin: "M"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:299"
is_a: MOD:00913 ! modified L-methionine residue
is_a: MOD:01152 ! carboxylated residue

[Term]
id: MOD:00369
name: O-acetyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-acetyl-L-serine." [ChEBI:17981, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, PubMed:16731519, PubMed:489587, PubMed:7309355, RESID:AA0364, Unimod:1#S]
comment: incidental to RESID:AA0051
subset: PSI-MOD-slim
synonym: "(2S)-3-(acetyloxy)-2-aminopropanoic acid" EXACT RESID-systematic []
synonym: "Acetyl" RELATED PSI-MS-label []
synonym: "Acetylation" RELATED Unimod-description []
synonym: "MOD_RES O-acetylserine" EXACT UniProt-feature []
synonym: "O-acetyl-L-serine" EXACT RESID-name []
synonym: "O-acetylated L-serine" EXACT PSI-MOD-alternate []
synonym: "O-acetylserine" EXACT RESID-alternate []
synonym: "OAcSer" EXACT PSI-MOD-label []
synonym: "serine acetate ester" EXACT RESID-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1"
xref: uniprot.ptm:PTM-0232
is_a: MOD:00644 ! mono O-acetylated residue
is_a: MOD:00647 ! monoacetylated L-serine
is_a: MOD:02003 ! O3-acylated L-serine

[Term]
id: MOD:00370
name: (E)-2,3-didehydrotyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to (E)-2,3-didehydrotyrosine." [PubMed:12623015, RESID:AA0365]
comment: incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381
subset: PSI-MOD-slim
synonym: "(2E)-2-amino-3-(4-hydroxyphenyl)prop-2-enoic acid" EXACT RESID-systematic []
synonym: "(E)-2,3-didehydrogenated tyrosine" EXACT PSI-MOD-alternate []
synonym: "(E)-2,3-didehydrotyrosine" EXACT RESID-name []
synonym: "2-amino-3-oxo-butanoic_acid" RELATED Unimod-description []
synonym: "amino-(para-hydroxybenzylidenyl)acetic acid" EXACT RESID-alternate []
synonym: "blue non-fluorescent pocilloporin chromophore" EXACT RESID-alternate []
synonym: "Didehydro" RELATED PSI-MS-label []
synonym: "E-dHTyr" EXACT PSI-MOD-label []
synonym: "MOD_RES (E)-2,3-didehydrotyrosine" EXACT UniProt-feature []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
synonym: "trans-dehydrotyrosine" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 9 H 7 N 1 O 2"
xref: MassAvg: "161.16"
xref: MassMono: "161.047678"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0001
is_a: MOD:00706 ! dehydrogenated tyrosine

[Term]
id: MOD:00371
name: bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide
def: "A protein modification that effectively converts two L-aspartic acid residues, three L-glutamic acid residues, an L-histidine residue, and a one-calcium, four-iron, four-oxygen cluster to bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide." [PubMed:14764885, RESID:AA0366]
comment: Cross-link 6.
synonym: "4Mn-Ca-4O cluster" EXACT RESID-alternate []
synonym: "bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide" EXACT RESID-name []
synonym: "mu3-1:2:3kappaO-oxido-mu3-1:3:4kappaO-oxido-mu3-2:3:4kappaO-oxido-mu4-1:2:4:5kappaO-oxido-N1'-histidino-O5-glutamato 2-manganese-O5,O5-glutamato 3-manganese-O4-aspartato 4-manganese-O4-aspartato-O5-glutamato 5-manganese" EXACT RESID-systematic []
synonym: "photosystem II catalytic cluster" EXACT RESID-alternate []
xref: DiffAvg: "317.78"
xref: DiffFormula: "C 0 Ca 1 H -6 Mn 4 N 0 O 4"
xref: DiffMono: "317.647480"
xref: Formula: "C 29 Ca 1 H 32 Mn 4 N 8 O 20"
xref: MassAvg: "1072.44"
xref: MassMono: "1071.888057"
xref: Origin: "D, D, E, E, E, H"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00740 ! manganese containing modified residue
is_a: MOD:02066 ! metal or metal cluster coordinated L-aspartic acid residue
is_a: MOD:02068 ! metal or metal cluster coordinated L-glutamic acid residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue
is_a: MOD:01482 ! calcium containing modified residue

[Term]
id: MOD:00372
name: 3'-(3'-L-tyrosinyl)-L-tyrosine
def: "A protein modification that effectively cross-links two L-tyrosine residues with a carbon-carbon bond to form 3'-(3'-L-tyrosinyl)-L-tyrosine." [DeltaMass:0, PubMed:14249161, PubMed:637884, PubMed:8702710, PubMed:8937563, RESID:AA0367]
comment: Cross-link 2; From DeltaMass: Average Mass: -2.
synonym: "(2S,2'S)-3,3'-(6,6'-dihydroxybiphenyl-3,3'-diyl)bis(2-aminopropanoic acid)" EXACT RESID-systematic []
synonym: "3'-(L-tyros-3'-yl)-L-tyrosine" EXACT RESID-name []
synonym: "3,3'-BiTyr (Crosslink)" EXACT DeltaMass-label []
synonym: "6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-bis(2-aminopropanoic acid)" EXACT RESID-alternate []
synonym: "alpha,alpha'-diamino-6,6'-dihydroxy-(1,1'-biphenyl)-3,3'-dipropanoic acid" EXACT RESID-alternate []
synonym: "bityrosine" EXACT RESID-alternate []
synonym: "o,o-dityrosine" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 18 H 16 N 2 O 4"
xref: MassAvg: "324.34"
xref: MassMono: "324.111007"
xref: Origin: "Y, Y"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02058 ! crosslinked L-tyrosine residue

[Term]
id: MOD:00373
name: 3'-(O4'-L-tyrosinyl)-L-tyrosine
def: "A protein modification that effectively cross-links L-tyrosine residues with an ether bond to form 3'-(O4'-L-tyrosinyl)-L-tyrosine." [DeltaMass:0, PubMed:12719529, PubMed:7115340, PubMed:8702710, RESID:AA0368]
comment: Cross-link 2; secondary to RESID:AA0146; From DeltaMass: Average Mass: -2.
synonym: "(2S)-2-amino-3-[3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-4-hydroxyphenyl]propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-[4-(5-[(2S)-2-amino-2-carboxyethyl]-2-hydroxyphenoxy)phenyl]propanoic acid" EXACT RESID-alternate []
synonym: "3'-(L-tyros-O4'-yl)-L-tyrosine" EXACT RESID-name []
synonym: "CROSSLNK Isodityrosine (Tyr-Tyr)" EXACT UniProt-feature []
synonym: "IsodiTyr (Crosslink)" EXACT DeltaMass-label []
synonym: "isodityrosine" EXACT RESID-alternate []
synonym: "O-(5-(2-amino-2-carboxyethyl)-2-hydroxyphenyl)-L-tyrosine" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 18 H 16 N 2 O 4"
xref: MassAvg: "324.34"
xref: MassMono: "324.111007"
xref: Origin: "Y, Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0155
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02058 ! crosslinked L-tyrosine residue

[Term]
id: MOD:00374
name: 3,4-dihydroxy-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to 3,4-dihydroxy-L-arginine." [PubMed:10978343, PubMed:12686488, RESID:AA0369, Unimod:425#R, ChEBI:141829]
synonym: "(2S,3Xi,4Xi)-2-amino-5-carbamimidamido-3,4-dihydroxypentanoic acid" EXACT RESID-systematic []
synonym: "2-amino-5-guanidino-3,4-dihydroxypentanoic acid" EXACT RESID-alternate []
synonym: "3,4-dihydroxy-L-arginine" EXACT RESID-name []
synonym: "3,4-dihydroxylated L-arginine" EXACT PSI-MOD-alternate []
synonym: "34Hy2Arg" EXACT PSI-MOD-label []
synonym: "beta,gamma-dihydroxyarginine" EXACT RESID-alternate []
synonym: "dihydroxy" RELATED Unimod-description []
synonym: "Dioxidation" RELATED PSI-MS-label []
synonym: "MOD_RES 3,4-dihydroxyarginine" EXACT UniProt-feature []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 6 H 12 N 4 O 3"
xref: MassAvg: "188.19"
xref: MassMono: "188.090940"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:425"
xref: uniprot.ptm:PTM-0022
is_a: MOD:00428 ! dihydroxylated residue
is_a: MOD:00682 ! hydroxylated arginine

[Term]
id: MOD:00375
name: 4,5-dihydroxy-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 4,5-dihydroxy-L-lysine." [PubMed:10978343, PubMed:12686488, RESID:AA0370, Unimod:425#K]
synonym: "(2S,4Xi,5Xi)-2,6-diamino-4,5-dihydroxyhexanoic acid" EXACT RESID-systematic []
synonym: "4,5-dihydroxy-L-lysine" EXACT RESID-name []
synonym: "4,5-dihydroxylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "45Hy2Lys" EXACT PSI-MOD-label []
synonym: "alpha,epsilon-diamino-delta,gamma-dihydroxycaproic acid" EXACT RESID-alternate []
synonym: "delta,gamma-dihydroxylysine" EXACT RESID-alternate []
synonym: "dihydroxy" RELATED Unimod-description []
synonym: "Dioxidation" RELATED PSI-MS-label []
synonym: "MOD_RES 4,5-dihydroxylysine" EXACT UniProt-feature []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 6 H 12 N 2 O 3"
xref: MassAvg: "160.17"
xref: MassMono: "160.084792"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:425"
xref: uniprot.ptm:PTM-0036
is_a: MOD:00428 ! dihydroxylated residue
is_a: MOD:00681 ! hydroxylated lysine

[Term]
id: MOD:00376
name: 1'-(phospho-5'-adenosine)-L-histidine
def: "A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form 1'-(phospho-5'-adenosine)-L-histidine." [PubMed:15182206, PubMed:9323207, RESID:AA0371, Unimod:405#H]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-[1-(5'-adenosine phosphono)imidazol-4-yl]propanoic acid" EXACT RESID-systematic []
synonym: "1'-(phospho-5'-adenosine)-L-histidine" EXACT RESID-name []
synonym: "ACT_SITE Tele-AMP-histidine intermediate" EXACT UniProt-feature []
synonym: "AMP binding site" RELATED Unimod-description []
synonym: "L-histidine 5'-adenosine phosphoramidester" EXACT RESID-alternate []
synonym: "L-histidine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate []
synonym: "N(tau)-5'-adenylic-L-histidine" EXACT RESID-alternate []
synonym: "N1'-adenylylated histidine" EXACT RESID-alternate []
synonym: "Phosphoadenosine" RELATED PSI-MS-label []
synonym: "tele-5'-adenylic-L-histidine" EXACT RESID-alternate []
xref: DiffAvg: "329.21"
xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1"
xref: DiffMono: "329.052520"
xref: Formula: "C 16 H 19 N 8 O 7 P 1"
xref: MassAvg: "466.35"
xref: MassMono: "466.111432"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:405"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01165 ! adenylated residue

[Term]
id: MOD:00377
name: 1'-(phospho-5'-uridine)-L-histidine
def: "A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphouridine through a phosphoramide ester bond to form 1'-(phospho-5'-uridine)-L-histidine." [PubMed:11467524, PubMed:321007, PubMed:380639, PubMed:8794735, RESID:AA0372, Unimod:417#H]
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-[1-(5'-uridine phosphono)imidazol-4-yl]propanoic acid" EXACT RESID-systematic []
synonym: "1'-(phospho-5'-uridine)-L-histidine" EXACT RESID-name []
synonym: "ACT_SITE Tele-UMP-histidine intermediate" EXACT UniProt-feature []
synonym: "L-histidine 5'-uridine phosphoramidester" EXACT RESID-alternate []
synonym: "L-histidine monoanhydride with 5'-uridylic acid" EXACT RESID-alternate []
synonym: "N(tau)-5'-uridylic-L-histidine" EXACT RESID-alternate []
synonym: "N1'-uridylylated histidine" EXACT RESID-alternate []
synonym: "PhosphoUridine" RELATED PSI-MS-label []
synonym: "tele-5'-uridylic-L-histidine" EXACT RESID-alternate []
synonym: "uridine phosphodiester" RELATED Unimod-description []
synonym: "MOD_RES O-UMP-histidine" EXACT UniProt-feature []
xref: DiffAvg: "306.17"
xref: DiffFormula: "C 9 H 11 N 2 O 8 P 1"
xref: DiffMono: "306.025302"
xref: Formula: "C 15 H 18 N 5 O 9 P 1"
xref: MassAvg: "443.31"
xref: MassMono: "443.084214"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:417"
xref: uniprot.ptm:PTM-0500
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01166 ! uridylated residue

[Term]
id: MOD:00378
name: L-aspartyl semialdehyde
def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl semialdehyde." [PubMed:1093385, PubMed:14235557, PubMed:15237995, RESID:AA0373, Unimod:447#D]
subset: PSI-MOD-slim
synonym: "(S)-2-amino-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "aspartyl 4-semialdehyde" EXACT PSI-MOD-alternate []
synonym: "aspartyl aldehyde" EXACT PSI-MOD-alternate []
synonym: "Deoxy" RELATED PSI-MS-label []
synonym: "L-aminosuccinaldehydic acid" EXACT RESID-alternate []
synonym: "L-aminosuccinic acid semialdehyde" EXACT RESID-alternate []
synonym: "L-aspartate-beta-semialdehyde" EXACT RESID-alternate []
synonym: "L-aspartic beta-semialdehyde" EXACT RESID-alternate []
synonym: "L-aspartyl aldehyde" EXACT RESID-name []
synonym: "L-beta-formylalanine" EXACT RESID-alternate []
synonym: "MOD_RES Aspartyl aldehyde" EXACT UniProt-feature []
synonym: "reduction" RELATED Unimod-description []
xref: DiffAvg: "-16.00"
xref: DiffFormula: "C 0 H 0 N 0 O -1"
xref: DiffMono: "-15.994915"
xref: Formula: "C 4 H 5 N 1 O 2"
xref: MassAvg: "99.09"
xref: MassMono: "99.032028"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:447"
xref: uniprot.ptm:PTM-0064
is_a: MOD:00904 ! modified L-aspartic acid residue
is_a: MOD:01161 ! deoxygenated residue

[Term]
id: MOD:00379
name: L-serine microcin E492 siderophore ester
def: "A protein modification that effectively converts an L-serine residue to L-serine microcin E492 siderophore ester." [PubMed:15102848, RESID:AA0374, Unimod:448#C-term]
comment: Unimod origin corrected [JSG].
synonym: "L-serine microcin E492 siderophore ester" EXACT RESID-name []
synonym: "Microcin" RELATED PSI-MS-label []
synonym: "microcin E492 siderophore ester from serine" RELATED Unimod-description []
synonym: "MOD_RES Serine microcin E492 siderophore ester" EXACT UniProt-feature []
synonym: "N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine" EXACT RESID-systematic []
xref: DiffAvg: "831.69"
xref: DiffFormula: "C 36 H 37 N 3 O 20"
xref: DiffMono: "831.197041"
xref: Formula: "C 39 H 43 N 4 O 23"
xref: MassAvg: "935.78"
xref: MassMono: "935.231809"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:448"
xref: uniprot.ptm:PTM-0276
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00380
name: L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)
def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." [PubMed:12910261, PubMed:14725769, RESID:AA0375, Unimod:424#D]
synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate []
synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-aspartyl-molybdenum" EXACT RESID-systematic []
synonym: "L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name []
synonym: "molybdenum bis(molybdopterin guanine dinucleotide)" RELATED Unimod-description []
synonym: "MolybdopterinGD" RELATED PSI-MS-label []
synonym: "nitrate reductase A aspartyl Mo-bisMGD cofactor" EXACT RESID-alternate []
synonym: "phosphoric acid 4-(2-amino-4-oxo-3,4,5,6,-tetrahydro-pteridin-6-yl)-2-hydroxy-3,4-dimercapto-but-3-en-yl ester guanylate ester" EXACT RESID-alternate []
xref: DiffAvg: "1572.02"
xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4"
xref: DiffMono: "1572.985775"
xref: Formula: "C 44 H 52 Mo 1 N 21 O 29 P 4 S 4"
xref: MassAvg: "1687.10"
xref: MassMono: "1688.012718"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:424"
is_a: MOD:02066 ! metal or metal cluster coordinated L-aspartic acid residue
is_a: MOD:01167 ! molybdopterin guanine dinucleotide

[Term]
id: MOD:00381
name: L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Sec)
def: "A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)." [PubMed:11372198, PubMed:12220497, RESID:AA0376#SEC]
xref: DiffAvg: "1691.97"
xref: DiffFormula: "C 40 H 47 N 20 O 26 P 4 S 5 Se 0 W 1"
xref: DiffMono: "1691.003369"
xref: Formula: "C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1"
xref: MassAvg: "1842.02"
xref: MassMono: "1841.957004"
xref: Origin: "U"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00746 ! tungsten containing modified residue
is_a: MOD:00748 ! pterin modified residue
is_a: MOD:02073 ! metal or metal cluster coordinated L-selenocysteine residue

[Term]
id: MOD:00382
name: 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one
def: "A protein modification that effectively crosslinks an L-methionyl-L-tyrosine dipeptide to form 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one." [PubMed:10852900, PubMed:11259412, PubMed:15491166, RESID:AA0377]
comment: carboxamidine; cross-link 1. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "3-(2-methylsulfanyl)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one" EXACT RESID-systematic []
synonym: "3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-amino-3,6-didehydropyrazin-2-ol" EXACT RESID-alternate []
synonym: "3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one" EXACT RESID-name []
synonym: "GFP-like chromoprotein asFP595 chromophore" EXACT RESID-alternate []
synonym: "L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine" EXACT RESID-alternate []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 14 H 15 N 2 O 2 S 1"
xref: MassAvg: "275.35"
xref: MassMono: "275.085424"
xref: Origin: "M, Y"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
is_a: MOD:02052 ! crosslinked L-methionine residue
is_a: MOD:02058 ! crosslinked L-tyrosine residue

[Term]
id: MOD:00383
name: 2-imino-glutamic acid 5-imidazolinone glycine
def: "A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue to form 2-imino-glutamic acid 5-imidazolinone glycine." [PubMed:11682051, RESID:AA0378]
comment: Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365.
synonym: "2,N-didehydroglutamyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "2-(3-carboxy-1-iminopropyl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate []
synonym: "2-imino-glutamic acid 5-imidazolinone glycine" EXACT RESID-name []
synonym: "2-imino-glutamyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "4-[1-(carboxymethyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-4-iminobutanoic acid" EXACT RESID-systematic []
synonym: "[2-(3-carboxy-1-iminopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate []
synonym: "CROSSLNK 2-iminomethyl-5-imidazolinone (Glu-Gly)" EXACT UniProt-feature []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1"
xref: DiffMono: "-20.026215"
xref: Formula: "C 7 H 6 N 2 O 3"
xref: MassAvg: "166.14"
xref: MassMono: "166.037842"
xref: Origin: "E, G"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0014
is_a: MOD:02045 ! crosslinked L-glutamic acid residue
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly)

[Term]
id: MOD:00384
name: 2-imino-methionine 5-imidazolinone glycine
def: "A protein modification that effectively crosslinks an L-methionine residue and a glycine residue to form 2-imino-methionine 5-imidazolinone glycine." [PubMed:10852900, PubMed:12185250, PubMed:12909624, PubMed:15542608, RESID:AA0379]
comment: Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365.
synonym: "(2-[1-imino-3-(methylsulfanyl)propyl]-5-oxo-4,5-dihydro-imidazol-1-yl)acetic acid" EXACT RESID-alternate []
synonym: "(2-[3-(methylsulfanyl)propanimidoyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic []
synonym: "2,N-didehydromethionyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "2-[1-imino-3-(methylsulfanyl)propyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate []
synonym: "2-imino-methionine 5-imidazolinone glycine" EXACT RESID-name []
synonym: "2-imino-methionyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "CROSSLNK 2-iminomethyl-5-imidazolinone (Met-Gly)" EXACT UniProt-feature []
synonym: "GFP-like chromoprotein asFP595 chromophore" EXACT RESID-alternate []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
synonym: "red fluorescent protein eqFP611 chromophore" EXACT RESID-alternate []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 7 H 8 N 2 O 1 S 1"
xref: MassAvg: "168.21"
xref: MassMono: "168.035734"
xref: Origin: "G, M"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0015
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:02052 ! crosslinked L-methionine residue
is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly)

[Term]
id: MOD:00385
name: L-asparagine 5-imidazolinone glycine
def: "A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue to form L-asparagine 5-imidazolinone glycine." [PubMed:10504696, RESID:AA0380]
comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365.
synonym: "(2-[(1S)-1,3-diamino-3-oxopropyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic []
synonym: "2-[(S)-1,3-diamino-3-oxopropyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate []
synonym: "[2-(1,3-diamino-3-oxopropyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate []
synonym: "asparaginyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "CROSSLNK 5-imidazolinone (Asn-Gly)" EXACT UniProt-feature []
synonym: "L-asparagine 5-imidazolinone glycine" EXACT RESID-name []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
synonym: "Zoanthus sp. fluorescent protein FP506 chromophore" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 6 H 7 N 3 O 2"
xref: MassAvg: "153.14"
xref: MassMono: "153.053826"
xref: Origin: "G, N"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0046
is_a: MOD:02042 ! crosslinked L-asparagine residue
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly)
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00386
name: L-lysine 5-imidazolinone glycine
def: "A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form L-lysine 5-imidazolinone glycine." [PubMed:10504696, RESID:AA0381]
comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365.
synonym: "(2-[(1S)-1,5-diaminopentyl]-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic []
synonym: "2-[(S)-1,5-diaminopentanyl]-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate []
synonym: "[2-(1,5-diaminopentanyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate []
synonym: "Anemonia majano fluorescent protein FP486 chromophore" EXACT RESID-alternate []
synonym: "CROSSLNK 5-imidazolinone (Lys-Gly)" EXACT UniProt-feature []
synonym: "L-lysine 5-imidazolinone glycine" EXACT RESID-name []
synonym: "lysyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 8 H 13 N 3 O 1"
xref: MassAvg: "167.21"
xref: MassMono: "167.105862"
xref: Origin: "G, K"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0048
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly)
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00387
name: 2-tetrahydropyridinyl-5-imidazolinone glycine
def: "A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form 2-tetrahydropyridinyl-5-imidazolinone glycine." [PubMed:10504696, PubMed:15628861, RESID:AA0382]
comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365.
synonym: "2-(3,4,5,6-tetrahydropyridin-2-yl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate []
synonym: "2-(tetrahydropyrid-2-yl)-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "2-tetrahydropyridinyl-5-imidazolinone glycine" EXACT RESID-name []
synonym: "[5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid" EXACT RESID-alternate []
synonym: "[5-oxo-2-(3,4,5,6-tetrahydropyridin-2-yl)-4,5-dihydro-1H-imidazol-1-yl]acetic acid" EXACT RESID-systematic []
synonym: "CROSSLNK 2-tetrahydro-2-pyridyl-5-imidazolinone (Lys-Gly)" EXACT UniProt-feature []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
synonym: "Zoanthus sp. fluorescent protein zFP538 chromophore" EXACT RESID-alternate []
xref: DiffAvg: "-37.06"
xref: DiffFormula: "C 0 H -7 N -1 O -1"
xref: DiffMono: "-37.052764"
xref: Formula: "C 8 H 9 N 2 O 1"
xref: MassAvg: "149.17"
xref: MassMono: "149.071488"
xref: Origin: "G, K"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0018
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly)

[Term]
id: MOD:00388
name: L-alanyl-pentaglycyl-murein peptidoglycan
def: "A protein modification that effectively attaches an L-alanine residue to murein peptidoglycan by a pentaglycine linker peptide." [PubMed:8163519, RESID:AA0383]
synonym: "(2R,6S)-2-(N-mureinyl-(R)-alanyl-(S)-isoglutamyl)amino-6-(alanyl-pentaglycyl)amino-pimeloyl-(S)-alanyl-(S)-alanine" EXACT RESID-alternate []
synonym: "L-alanyl-pentaglycyl-murein peptidoglycan" EXACT RESID-name []
synonym: "MOD_RES Pentaglycyl murein peptidoglycan amidated alanine" EXACT UniProt-feature []
xref: Origin: "A"
xref: Source: "hypothetical"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0245
is_a: MOD:00901 ! modified L-alanine residue
is_a: MOD:01159 ! peptidoglycanated residue

[Term]
id: MOD:00389
name: N-formyl-L-proline
def: "A protein modification that effectively converts an L-proline residue to N-formyl-L-proline." [PubMed:12051774, PubMed:5464655, RESID:AA0384, Unimod:122#N-term]
comment: CAUTION - observations of this modification can be attributed to unintended artifactual production, or to spurious peptide MS identification. This modification is probably not a natural post-translational modification [JSG].
synonym: "(2S)-1-formylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "1-formyl-2-pyrrolidinecarboxylic acid" EXACT RESID-alternate []
synonym: "1-formylproline" EXACT RESID-alternate []
synonym: "N-formyl-L-proline" EXACT RESID-name []
synonym: "N-formylated L-proline" EXACT PSI-MOD-alternate []
synonym: "NFoPro" EXACT PSI-MOD-label []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 H 0 N 0 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "C 6 H 8 N 1 O 2"
xref: MassAvg: "126.14"
xref: MassMono: "126.055504"
xref: Origin: "P"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:122"
is_a: MOD:00409 ! N-formylated residue
is_a: MOD:00915 ! modified L-proline residue
is_a: MOD:01696 ! alpha-amino acylated residue

[Term]
id: MOD:00390
name: O-decanoyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-decanoyl-L-serine." [PubMed:12630926, RESID:AA0385, Unimod:449#S]
synonym: "(2S)-2-amino-3-(decanoyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "Decanoyl" RELATED PSI-MS-label []
synonym: "L-serine decanoate ester" EXACT RESID-alternate []
synonym: "lipid" RELATED Unimod-description []
synonym: "LIPID O-decanoyl serine" EXACT UniProt-feature []
synonym: "O-decanoyl-L-serine" EXACT RESID-name []
synonym: "O-decanoylated L-serine" EXACT PSI-MOD-alternate []
synonym: "O3-decanoyl-L-serine" EXACT RESID-alternate []
synonym: "ODecSer" EXACT PSI-MOD-label []
xref: DiffAvg: "154.25"
xref: DiffFormula: "C 10 H 18 N 0 O 1"
xref: DiffMono: "154.135765"
xref: Formula: "C 13 H 23 N 1 O 3"
xref: MassAvg: "241.33"
xref: MassMono: "241.167794"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:449"
xref: uniprot.ptm:PTM-0234
is_a: MOD:00668 ! O-decanoylated residue
is_a: MOD:02003 ! O3-acylated L-serine

[Term]
id: MOD:00391
name: O-octanoyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-octanoyl-L-threonine." [PubMed:11546772, PubMed:12716131, RESID:AA0386, Unimod:426#T]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(octanoyloxy)butanoic acid" EXACT RESID-systematic []
synonym: "L-threonine octanoate ester" EXACT RESID-alternate []
synonym: "LIPID O-octanoyl threonine" EXACT UniProt-feature []
synonym: "O-octanoyl-L-threonine" EXACT RESID-name []
synonym: "O-octanoylated L-threonine" EXACT PSI-MOD-alternate []
synonym: "O3-octanoyl-L-threonine" EXACT RESID-alternate []
synonym: "Octanoyl" RELATED PSI-MS-label []
synonym: "octanoyl" RELATED Unimod-description []
synonym: "OOctThr" EXACT PSI-MOD-label []
xref: DiffAvg: "126.20"
xref: DiffFormula: "C 8 H 14 N 0 O 1"
xref: DiffMono: "126.104465"
xref: Formula: "C 12 H 21 N 1 O 3"
xref: MassAvg: "227.30"
xref: MassMono: "227.152144"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:426"
xref: uniprot.ptm:PTM-0240
is_a: MOD:00669 ! O-octanoylated residue
is_a: MOD:02004 ! O3-acylated L-threonine

[Term]
id: MOD:00392
name: O-decanoyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-decanoyl-L-threonine." [PubMed:11546772, RESID:AA0387, Unimod:449#T]
synonym: "(2S)-2-amino-3-(decanoyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "Decanoyl" RELATED PSI-MS-label []
synonym: "L-threonine decanoate ester" EXACT RESID-alternate []
synonym: "lipid" RELATED Unimod-description []
synonym: "LIPID O-decanoyl threonine" EXACT UniProt-feature []
synonym: "O-decanoyl-L-threonine" EXACT RESID-name []
synonym: "O-decanoylated L-threonine" EXACT PSI-MOD-alternate []
synonym: "O3-decanoyl-L-threonine" EXACT RESID-alternate []
synonym: "ODecThr" EXACT PSI-MOD-label []
xref: DiffAvg: "154.25"
xref: DiffFormula: "C 10 H 18 N 0 O 1"
xref: DiffMono: "154.135765"
xref: Formula: "C 14 H 25 N 1 O 3"
xref: MassAvg: "255.36"
xref: MassMono: "255.183444"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:449"
xref: uniprot.ptm:PTM-0235
is_a: MOD:00668 ! O-decanoylated residue
is_a: MOD:02004 ! O3-acylated L-threonine

[Term]
id: MOD:00393
name: O-methylated residue
def: "A protein modification that effectively replaces a hydroxyl group hydrogen with a methyl group to produce either an ether from an alcohol or an ester from an acid." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OMeRes" EXACT PSI-MOD-label []
is_a: MOD:00427 ! methylated residue

[Term]
id: MOD:00394
name: monoacetylated residue
def: "A protein modification that effectively replaces one hydrogen atom with one acetyl group." [DeltaMass:0, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, Unimod:1]
comment: Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). From DeltaMass: Average Mass: 42
subset: PSI-MOD-slim
synonym: "Acetyl" RELATED PSI-MS-label []
synonym: "Acetylation" RELATED Unimod-description []
synonym: "Acetylation (N terminus, N epsilon of Lysine, O of Serine) (Ac)" EXACT DeltaMass-label []
synonym: "Ac1Res" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1"
is_a: MOD:02078 ! acetylated residue

[Term]
id: MOD:00395
name: thioester crosslinked residues
def: "A protein modification that crosslinks two residues by formation of a thioester bond between a cysteine thiol and either an alpha-carbonyl, as in S-(L-methionyl-L-cysteine), or a sidechain carbonyl, as in S-(L-isoglutamyl)-L-cysteine." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00033 ! crosslinked residues
is_a: MOD:02044 ! crosslinked L-cysteine residue

[Term]
id: MOD:00396
name: O-glycosylated residue
def: "A protein modification that effectively replaces a residue hydrogen atom on an oxygen with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OGlycoRes" EXACT PSI-MOD-label []
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00397
name: iodoacetamide derivatized residue
def: "A protein modification that is produced by reaction with iodoacetamide, usually replacement of a reactive hydrogen with a methylcarboxamido group." [PubMed:11327326, PubMed:11510821, PubMed:12422359, Unimod:4]
subset: PSI-MOD-slim
synonym: "Carbamidomethyl" RELATED PSI-MS-label []
synonym: "Iodoacetamide derivative" RELATED Unimod-description []
xref: DiffAvg: "57.05"
xref: DiffFormula: "C 2 H 3 N 1 O 1"
xref: DiffMono: "57.021464"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:4"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00398
name: carbamoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a carbamoyl (carboxamido) group. Replacement of an amino hydrogen produces a ureido group." [DeltaMass:56, PubMed:10978403, PubMed:12203680, Unimod:5]
comment: This modification can be produced by hydrogen cyanate, either used as a reagent or as released by urea degradation in solution [JSG].
subset: PSI-MOD-slim
synonym: "Carbamyl" RELATED Unimod-interim []
synonym: "Carbamylation" EXACT DeltaMass-label []
synonym: "Carbamylation" RELATED Unimod-description []
xref: DiffAvg: "43.02"
xref: DiffFormula: "C 1 H 1 N 1 O 1"
xref: DiffMono: "43.005814"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:5"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00399
name: iodoacetic acid derivatized residue
def: "A protein modification that is produced by reaction with iodoacetic acid, usually replacement of a reactive hydrogen with a methylcarboxy group." [DeltaMass:64, Unimod:6]
comment: From DeltaMass: Average Mass: 58 Abbreviation:CmC Average Mass Change:58 Notes:Cysteine reacts with iodoacetic acid to produce carboxymethyl cysteine.
subset: PSI-MOD-slim
synonym: "Carboxymethyl" RELATED PSI-MS-label []
synonym: "Carboxymethyl (on Cysteine)" EXACT DeltaMass-label []
synonym: "Iodoacetic acid derivative" RELATED Unimod-description []
xref: DiffAvg: "58.04"
xref: DiffFormula: "C 2 H 2 O 2"
xref: DiffMono: "58.005479"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:6"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00400
name: deamidated residue
def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group, with both a gain of oxygen and loss of a nitrogen and a hydrogen." [DeltaMass:32, OMSSA:4, Unimod:7]
comment: From DeltaMass: References:Vish Katta.
subset: PSI-MOD-slim
synonym: "Deamidated" RELATED PSI-MS-label []
synonym: "Deamidation" RELATED Unimod-description []
synonym: "Deamidation of Asparagine and Glutamine to Aspartate and Glutamate" EXACT DeltaMass-label []
synonym: "deamidationkq" EXACT OMSSA-label []
synonym: "dNRes" EXACT PSI-MOD-label []
xref: DiffAvg: "0.98"
xref: DiffFormula: "H -1 N -1 O 1"
xref: DiffMono: "0.984016"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:7"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00401
name: Gygi ICAT(TM) d0 modified cysteine
def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d0 reagent." [PubMed:10504701, Unimod:8#C]
synonym: "Gygi ICAT(TM) d0" RELATED Unimod-description []
synonym: "ICAT-G" RELATED PSI-MS-label []
xref: DiffAvg: "486.63"
xref: DiffFormula: "C 22 H 38 N 4 O 6 S 1"
xref: DiffMono: "486.251206"
xref: Formula: "C 25 H 43 N 5 O 7 S 2"
xref: MassAvg: "589.77"
xref: MassMono: "589.260391"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:8"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue
is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine

[Term]
id: MOD:00402
name: Gygi ICAT(TM) d8 modified cysteine
def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d8 reagent." [PubMed:10504701, Unimod:9#C]
synonym: "Gygi ICAT(TM) d8" RELATED Unimod-description []
synonym: "ICAT-G:2H(8)" RELATED PSI-MS-label []
xref: DiffAvg: "494.30"
xref: DiffFormula: "C 22 (1)H 30 (2)H 8 N 4 O 6 S 1"
xref: DiffMono: "494.301420"
xref: Formula: "C 25 (1)H 35 (2)H 8 N 5 O 7 S 2"
xref: MassAvg: "597.31"
xref: MassMono: "597.310605"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:9"
is_a: MOD:01431 ! (2)H deuterium tagged reagent
is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine

[Term]
id: MOD:00403
name: homoserine
def: "A protein modification that effectively converts an L-methionine residue to homoserine." [DeltaMass:113, OMSSA:56, Unimod:10#M]
comment: Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group and the following residue amino group.
subset: PSI-MOD-slim
synonym: "ctermpephsem" EXACT OMSSA-label []
synonym: "Homoserine" RELATED Unimod-description []
synonym: "Homoserine formed from Met by CNBr treatment" EXACT DeltaMass-label []
synonym: "Met->Hse" RELATED PSI-MS-label []
xref: DiffAvg: "-30.09"
xref: DiffFormula: "C -1 H -2 O 1 S -1"
xref: DiffMono: "-29.992806"
xref: Formula: "C 4 H 7 N 1 O 2"
xref: MassAvg: "101.10"
xref: MassMono: "101.047678"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:10"
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:00404
name: homoserine lactone
def: "A protein modification that effectively converts an L-methionine residue to homoserine lactone." [DeltaMass:90, OMSSA:57, Unimod:11#M]
comment: Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group. Under acid conditions the homoserine dehydrates to form the cyclic lactone.
subset: PSI-MOD-slim
synonym: "ctermpephselactm" EXACT OMSSA-label []
synonym: "Homoserine lactone" RELATED Unimod-description []
synonym: "Met->Hsl" RELATED Unimod-interim []
xref: DiffAvg: "-48.10"
xref: DiffFormula: "C -1 H -4 S -1"
xref: DiffMono: "-48.003371"
xref: Formula: "C 4 H 5 N 1 O 1"
xref: MassAvg: "83.09"
xref: MassMono: "83.037114"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:11"
is_a: MOD:00601 ! cyclized residue
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:00405
name: Applied Biosystems original ICAT(TM) d8 modified cysteine
def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d8 reagent." [Unimod:12#C]
subset: PSI-MOD-slim
synonym: "Applied Biosystems original ICAT(TM) d8" RELATED Unimod-description []
synonym: "ICAT-D:2H(8)" RELATED PSI-MS-label []
xref: DiffAvg: "450.28"
xref: DiffFormula: "C 20 (1)H 26 (2)H 8 N 4 O 5 S 1"
xref: DiffMono: "450.275205"
xref: Formula: "C 23 (1)H 31 (2)H 8 N 5 O 6 S 2"
xref: MassAvg: "553.28"
xref: MassMono: "553.284390"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:12"
is_a: MOD:01431 ! (2)H deuterium tagged reagent
is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine


[Term]
id: MOD:00406
name: Applied Biosystems original ICAT(TM) d0 modified cysteine
def: "A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d0 reagent." [Unimod:13#C]
subset: PSI-MOD-slim
synonym: "Applied Biosystems original ICAT(TM) d0" RELATED Unimod-description []
synonym: "ICAT-D" RELATED PSI-MS-label []
xref: DiffAvg: "442.22"
xref: DiffFormula: "C 20 (1)H 34 N 4 O 5 S 1"
xref: DiffMono: "442.224991"
xref: Formula: "C 23 (1)H 39 N 5 O 6 S 2"
xref: MassAvg: "545.23"
xref: MassMono: "545.234176"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:13"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue
is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine

[Term]
id: MOD:00407
name: residue methyl ester
def: "A protein modification that effectively replaces a carboxyl group with a carboxy methyl ester group. OBSOLETE because Unimod:14 merged with entry 34, remap to MOD:00599." [PubMed:18688235]
synonym: "ResOMe" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2"
xref: DiffMono: "14.015650"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:00599"
is_obsolete: true

[Term]
id: MOD:00408
name: mono N-acetylated residue
def: "A protein modification that effectively replaces a residue amino or imino hydrogen with an acetyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "N-Acetyl" EXACT PSI-MOD-alternate []
synonym: "N-Acetylation" EXACT PSI-MOD-alternate []
synonym: "NAcRes" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00394 ! monoacetylated residue
is_a: MOD:00670 ! N-acylated residue

[Term]
id: MOD:00409
name: N-formylated residue
def: "A protein modification that effectively replaces a residue amino group with a formamido group." [OMSSA:44, OMSSA:82]
subset: PSI-MOD-slim
synonym: "Formyl" RELATED PSI-MS-label []
synonym: "NFoRes" EXACT PSI-MOD-label []
synonym: "ntermformyl" EXACT OMSSA-label []
synonym: "ntermpepformyl" EXACT OMSSA-label []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00493 ! formylated residue
is_a: MOD:00670 ! N-acylated residue

[Term]
id: MOD:00410
name: S-(N-isopropylcarboxamidomethyl)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(N-isopropylcarboxamidomethyl)-L-cysteine." [OMSSA:84, PubMed:11465505, PubMed:8465942, Unimod:17#C]
synonym: "N-isopropylcarboxamidomethyl" RELATED Unimod-description []
synonym: "NIPCAM" RELATED PSI-MS-label []
synonym: "nipcam" EXACT OMSSA-label []
xref: DiffAvg: "99.13"
xref: DiffFormula: "C 5 H 9 N 1 O 1 S 0"
xref: DiffMono: "99.068414"
xref: Formula: "C 8 H 14 N 2 O 2 S 1"
xref: MassAvg: "202.27"
xref: MassMono: "202.077599"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:17"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00411
name: O18 label
def: "modification from Unimod Isotopic label. OBSOLETE because Unimod:18 is now merged with entry 258 remap to MOD:00581 'single 018 label'" [PubMed:18688235]
comment: A modification from Unimod:18
xref: DiffAvg: "2.00"
xref: DiffFormula: "(16)O -1 (18)O 1"
xref: DiffMono: "2.004246"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00581"
is_obsolete: true

[Term]
id: MOD:00412
name: oxidation
def: "modification from Unimod artifact. OBSOLETE because Unimod entry 19 is now merged with Unimod 35 remap to MOD:00425 'monohydroxylated residue'." [PubMed:18688235]
xref: DiffAvg: "16.00"
xref: DiffFormula: "O 1"
xref: DiffMono: "15.994915"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:00425"
is_obsolete: true

[Term]
id: MOD:00413
name: biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine derivatized cysteine
def: "A protein modification that is produced by reaction of a cysteine residue with biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine." [Unimod:20#C]
synonym: "Biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine" RELATED Unimod-description []
synonym: "PEO-Iodoacetyl-LC-Biotin" RELATED Unimod-interim []
xref: DiffAvg: "414.52"
xref: DiffFormula: "C 18 H 30 N 4 O 5 S 1"
xref: DiffMono: "414.193691"
xref: Formula: "C 21 H 35 N 5 O 6 S 2"
xref: MassAvg: "517.66"
xref: MassMono: "517.202876"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:20"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00414
name: monomethylated L-arginine
def: "A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with one methyl group." [DeltaMass:215, OMSSA:77, Unimod:34#R]
comment: From DeltaMass: formula incorrect, N and O reversed
subset: PSI-MOD-slim
synonym: "Me1Arg" EXACT PSI-MOD-label []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "methylr" EXACT OMSSA-label []
synonym: "N-methyl Arginyl" EXACT DeltaMass-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 14 N 4 O 1"
xref: MassAvg: "170.22"
xref: MassMono: "170.116761"
xref: Origin: "R"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00658 ! methylated arginine

[Term]
id: MOD:00415
name: phosphorylation without neutral loss
def: "modification from Unimod - OBSOLETE because Unimod entry 22 is now merged with entry 21 remap to MOD:00696 'phosphorylated residue'." [PubMed:18688235]
xref: DiffAvg: "79.98"
xref: DiffFormula: "H 1 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00696"
is_obsolete: true

[Term]
id: MOD:00416
name: phosphorylation of an hydroxyl amino acid with prompt loss of phosphate
def: "A change resulting in an alteration of the measured molecular mass of a peptide or protein hydroxyl amino acid phosphorylated promptly followed by secondary loss of a neutral trihydrogen phosphate molecular fragment." [Unimod:23]
comment: O4-phosphotyrosine does not lose phosphate by this mechanism. Unimod does not provide a citation for this particular modification [JSG].
subset: PSI-MOD-slim
synonym: "Dehydrated" RELATED Unimod-interim []
synonym: "Dehydration" RELATED Unimod-description []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "H -2 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:23"
is_a: MOD:00432 ! modified residue with neutral loss of phosphate
is_a: MOD:00704 ! dehydrated residue

[Term]
id: MOD:00417
name: S-carboxamidoethyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidoethyl-L-cysteine." [DeltaMass:72, OMSSA:5, PubMed:1481983, Unimod:24#C]
comment: From DeltaMass: References: Anal. Biochem. Vol 216 No. 1 p131 (citation not found) Notes: Residual acrylamide in SDS gels can label free cysteines to produce propionamido-Cys (also known as PAM-Cys)
synonym: "Acrylamide adduct" RELATED Unimod-description []
synonym: "PAM-Cys" EXACT DeltaMass-label []
synonym: "Propionamide" RELATED PSI-MS-label []
synonym: "Propionamide or Acrylamide adduct" EXACT DeltaMass-label []
synonym: "propionamidec" EXACT OMSSA-label []
synonym: "S-(3-amino-3-oxopropyl)cysteine" EXACT PSI-MOD-alternate []
synonym: "S-carbamoylethyl-L-cysteine" EXACT PSI-MOD-alternate []
synonym: "S-propanamide-L-cysteine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "71.08"
xref: DiffFormula: "C 3 H 5 N 1 O 1 S 0"
xref: DiffMono: "71.037114"
xref: Formula: "C 6 H 10 N 2 O 2 S 1"
xref: MassAvg: "174.22"
xref: MassMono: "174.046299"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:24"
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00418
name: pyridylacetylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an (pyridin-3-yl)acetyl group." [PubMed:9276974, Unimod:25]
comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG].
synonym: "Pyridylacetyl" RELATED PSI-MS-label []
synonym: "pyridylacetyl" RELATED Unimod-description []
xref: DiffAvg: "119.12"
xref: DiffFormula: "C 7 H 5 N 1 O 1"
xref: DiffMono: "119.037114"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:25"
is_a: MOD:00649 ! acylated residue
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00419
name: (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid
def: "A protein modification that effectively converts an L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid." [DeltaMass:336, PubMed:12643538, Unimod:26#C]
comment: From DeltaMass: A secondary modification affecting peptides with S-carbamoylmethyl-L-cysteine (CamC) at the N-terminus. These exist in enzymatic digests of proteins that have been S-alkylated with iodoacetamide. Cyclization of N-terminal CamC gives a residue of (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid. Peptides in which this has occurred become more hydrophobic, and lose 17 Da from the N-terminal residue.
synonym: "(R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid" EXACT DeltaMass-label []
synonym: "5-oxothiomorpholine-3-carboxylic acid" EXACT PSI-MOD-alternate []
synonym: "Otc" EXACT DeltaMass-label []
synonym: "Pyro-carbamidomethyl" RELATED Unimod-interim []
synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" EXACT DeltaMass-label []
synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" RELATED Unimod-description []
xref: DiffAvg: "40.02"
xref: DiffFormula: "C 2 H 0 N 0 O 1 S 0"
xref: DiffMono: "39.994915"
xref: Formula: "C 5 H 6 N 1 O 2 S 1"
xref: MassAvg: "144.17"
xref: MassMono: "144.011924"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:26"
is_a: MOD:00601 ! cyclized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00420
name: 2-pyrrolidone-5-carboxylic acid (Glu)
def: "A protein modification that effectively converts an L-glutamic acid residue to 2-pyrrolidone-5-carboxylic acid." [DeltaMass:16, OMSSA:109, PubMed:10214721, PubMed:1836357, PubMed:3473473, PubMed:8382902, RESID:AA0031#GLU, Unimod:27#E]
comment: From DeltaMass: References: The conversion of glutamic acid to pyroglutamic was reported for the beta-amyloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52 [DeltaMass]. The modification in amyloid protein is probably an artifact of treatment with strong acid under anhydrous conditions. Peptides with N-terminal glutamic acid isolated from single cells of Aplysia neurons show partial conversion to pyroglutamic acid, possibly dependent on a temperature sensitive factor [JSG].
synonym: "(2S)-5-oxo-2-pyrrolidinecarboxylic acid" EXACT RESID-systematic []
synonym: "2-oxopyrrolidine-5-carboxylic acid" EXACT RESID-alternate []
synonym: "2-pyrrolidone-5-carboxylic acid" EXACT RESID-name []
synonym: "5-oxoproline" EXACT RESID-alternate []
synonym: "5-oxopyrrolidine-2-carboxylic acid" EXACT RESID-alternate []
synonym: "5-pyrrolidone-2-carboxylic acid" EXACT RESID-alternate []
synonym: "Glu->pyro-Glu" RELATED PSI-MS-label []
synonym: "MOD_RES Pyrrolidone carboxylic acid (Glu)" EXACT UniProt-feature []
synonym: "ntermpeppyroe" EXACT OMSSA-label []
synonym: "PCA" EXACT RESID-alternate []
synonym: "PyrGlu(Glu)" EXACT PSI-MOD-label []
synonym: "Pyro-glu from E" RELATED Unimod-description []
synonym: "pyroglutamic acid" EXACT RESID-alternate []
synonym: "Pyroglutamic Acid formed from Glutamic Acid" EXACT DeltaMass-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 5 H 6 N 1 O 2"
xref: MassAvg: "112.11"
xref: MassMono: "112.039853"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:27"
xref: uniprot.ptm:PTM-0262
is_a: MOD:00906 ! modified L-glutamic acid residue
is_a: MOD:01048 ! 2-pyrrolidone-5-carboxylic acid

[Term]
id: MOD:00421
name: C-glycosylated residue
def: "A protein modification that effectively replaces a residue hydrogen atom on a carbon with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "CGlycoRes" EXACT PSI-MOD-label []
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00422
name: alpha-amino morpholine-2-acetylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a morpholine-2-acetyl group." [PubMed:10446193, Unimod:29#N-term]
comment: The Unimod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG].
synonym: "N-Succinimidyl-2-morpholine acetate" RELATED Unimod-description []
synonym: "N-succinimidylmorpholine-2-acetate alpha-amino derivative" EXACT PSI-MOD-alternate []
synonym: "SMA" RELATED PSI-MS-label []
xref: DiffAvg: "127.14"
xref: DiffFormula: "C 6 H 9 N 1 O 2"
xref: DiffMono: "127.063329"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:29"
is_a: MOD:01696 ! alpha-amino acylated residue
is_a: MOD:01813 ! morpholine-2-acetylated residue

[Term]
id: MOD:00423
name: monosodium salt
def: "A protein modification that effectively substitutes one sodium atom for one hydrogen atom." [DeltaMass:0, Unimod:30]
subset: PSI-MOD-slim
synonym: "Cation:Na" RELATED PSI-MS-label []
synonym: "Na1Res" EXACT PSI-MOD-label []
synonym: "Sodium" EXACT DeltaMass-label []
synonym: "Sodium adduct" RELATED Unimod-description []
xref: DiffAvg: "21.98"
xref: DiffFormula: "H -1 Na 1"
xref: DiffMono: "21.981944"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: TermSpec: "none"
xref: Unimod: "Unimod:30"
is_a: MOD:00747 ! sodium containing modified residue

[Term]
id: MOD:00424
name: S-pyridylethyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-pyridylethyl-L-cysteine." [DeltaMass:253, OMSSA:112, PubMed:11760118, PubMed:626389, PubMed:8297018, PubMed:8783016, Unimod:31#C]
comment: From DeltaMass: Formula:C10H12O2N1S1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:208.067 Average Mass Change:208.286 (mass incorrect, aggregate not delta) References:PE Sciex
synonym: "PECys" EXACT DeltaMass-label []
synonym: "Pyridylethyl" RELATED PSI-MS-label []
synonym: "Pyridylethyl Cystenyl" EXACT DeltaMass-label []
synonym: "S-pyridinylethyl-L-cysteine" EXACT PSI-MOD-alternate []
synonym: "S-pyridylethylation" RELATED Unimod-description []
synonym: "spyridylethylc" EXACT OMSSA-label []
synonym: "vinylpyridine derivatized cysteine residue" EXACT PSI-MOD-alternate []
xref: DiffAvg: "105.14"
xref: DiffFormula: "C 7 H 7 N 1"
xref: DiffMono: "105.057849"
xref: Formula: "C 10 H 12 N 2 O 1 S 1"
xref: MassAvg: "208.28"
xref: MassMono: "208.067034"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:31"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00425
name: monohydroxylated residue
def: "A protein modification that effectively replaces one hydrogen atom with a hydroxyl group." [Unimod:35]
subset: PSI-MOD-slim
synonym: "Hy1Res" EXACT PSI-MOD-label []
synonym: "Oxidation" RELATED Unimod-interim []
synonym: "Oxidation or Hydroxylation" RELATED Unimod-description []
xref: DiffAvg: "16.00"
xref: DiffFormula: "O 1"
xref: DiffMono: "15.994915"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:35"
is_a: MOD:00677 ! hydroxylated residue

[Term]
id: MOD:00426
name: S-glycosylated residue
def: "A protein modification that effectively replaces a residue hydrogen atom on a sulfur with a carbohydrate-like group through a glycosidic bond." [PubMed:18688235]
synonym: "SGlycoRes" EXACT PSI-MOD-label []
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00427
name: methylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a methyl group." [DeltaMass:36]
comment: From DeltaMass: Average Mass: 14 Average Mass Change:14 References:Methylation of Asparagine (found in phycobiliproteins) Klotz and Glazer (1987) J. Biol. Chem. 262; 17350-17355
subset: PSI-MOD-slim
synonym: "MeRes" EXACT PSI-MOD-label []
synonym: "Methylation (N terminus, N epsilon of Lysine, O of Serine, Threonine or C terminus, N of Asparagine)" EXACT DeltaMass-label []
is_a: MOD:00001 ! alkylated residue

[Term]
id: MOD:00428
name: dihydroxylated residue
def: "A protein modification that effectively replaces two hydrogen atoms with two hydroxyl groups." [PubMed:12686488, Unimod:425]
subset: PSI-MOD-slim
synonym: "dihydroxy" RELATED Unimod-description []
synonym: "Dioxidation" RELATED PSI-MS-label []
synonym: "Hy2Res" EXACT PSI-MOD-label []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:425"
is_a: MOD:00677 ! hydroxylated residue

[Term]
id: MOD:00429
name: dimethylated residue
def: "A protein modification that effectively replaces two hydrogen atoms with two methyl groups." [DeltaMass:0, PubMed:12964758, PubMed:14570711, Unimod:36]
comment: For amino-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts only for dimethylation and not protonation. The alternative Me2+Res process accounts for both protonation and dimethylation [JSG].
subset: PSI-MOD-slim
synonym: "di-Methylation" RELATED Unimod-description []
synonym: "Dimethyl" RELATED PSI-MS-label []
synonym: "Me2Res" EXACT PSI-MOD-label []
synonym: "N,N dimethylation (of Arginine or Lysine)" EXACT DeltaMass-label []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4"
xref: DiffMono: "28.031300"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:36"
is_a: MOD:00427 ! methylated residue

[Term]
id: MOD:00430
name: trimethylated residue
def: "A protein modification that effectively replaces three hydrogen atoms with three methyl groups." [PubMed:12590383, PubMed:3145979, PubMed:4304194, PubMed:6778808, PubMed:7093227, PubMed:8453381, Unimod:37]
comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative Me3+Res process accounts for both protonation and trimethylation.
subset: PSI-MOD-slim
synonym: "Me3Res" EXACT PSI-MOD-label []
synonym: "tri-Methylation" RELATED Unimod-description []
synonym: "Trimethyl" RELATED PSI-MS-label []
xref: DiffAvg: "42.08"
xref: DiffFormula: "C 3 H 6"
xref: DiffMono: "42.046950"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:37"
is_a: MOD:00427 ! methylated residue

[Term]
id: MOD:00431
name: modified residue with a secondary neutral loss
def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral molecular fragment." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "NLModRes" EXACT PSI-MOD-label []
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00432
name: modified residue with neutral loss of phosphate
def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "dPhosModRes" EXACT PSI-MOD-label []
is_a: MOD:00431 ! modified residue with a secondary neutral loss

[Term]
id: MOD:00433
name: monoglucosylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an glucose group through a glycosidic bond." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "GlcRes" EXACT PSI-MOD-label []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00761 ! monohexosylated residue
is_a: MOD:00726 ! glucosylated residue

[Term]
id: MOD:00434
name: hexosylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexose sugar group through a glycosidic bond." [DeltaMass:203, PubMed:15279557, Unimod:41]
comment: From DeltaMass: Average Mass: 162 Formula:C6 H10 05 Monoisotopic Mass Change:162.053 Average Mass Change:162.143 References:PE Sciex.
subset: PSI-MOD-slim
synonym: "Hex" EXACT PSI-MOD-label []
synonym: "Hex" RELATED PSI-MS-label []
synonym: "Hexose" RELATED Unimod-description []
synonym: "Hexoses (Fru, Gal, Glc, Man)" EXACT DeltaMass-label []
synonym: "O-Glycosyl-" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:41"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00435
name: O-phospho-L-serine with neutral loss of phosphate
def: "Covalent modification of a peptide or protein amino acid phosphorylated serine with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "dPhosOPhosSer" EXACT PSI-MOD-label []
xref: DiffAvg: "-97.99"
xref: DiffFormula: "C 0 H -3 N 0 O -4 P -1"
xref: DiffMono: "-97.976895"
xref: Formula: "C 3 H 3 N 1 O 1"
xref: MassAvg: "69.06"
xref: MassMono: "69.021464"
xref: Origin: "MOD:00046"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01151 ! phosphorylated residue with neutral loss of phosphate
relationship: derives_from MOD:00046 ! O-phospho-L-serine

[Term]
id: MOD:00436
name: N-acetylhexosaminylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylhexosamine group through a glycosidic bond." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "HexNAc" EXACT PSI-MOD-label []
synonym: "N-Acetylhexosamine" RELATED Unimod-description []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: GNOme: "GNO:G29068FM"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00437
name: farnesylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a farnesyl group." [DeltaMass:0, PubMed:15609361, Unimod:44]
comment: From DeltaMass: Average Mass: 204
subset: PSI-MOD-slim
synonym: "Farnesyl" RELATED PSI-MS-label []
synonym: "Farnesylation" EXACT DeltaMass-label []
synonym: "Farnesylation" RELATED Unimod-description []
synonym: "FarnRes" EXACT PSI-MOD-label []
xref: DiffAvg: "204.36"
xref: DiffFormula: "C 15 H 24"
xref: DiffMono: "204.187801"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:44"
is_a: MOD:00703 ! isoprenylated residue

[Term]
id: MOD:00438
name: myristoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a myristoyl group." [DeltaMass:0, Unimod:45]
comment: From DeltaMass: Average Mass: 210
subset: PSI-MOD-slim
synonym: "C14:0 aliphatic acylated residue" EXACT PSI-MOD-alternate []
synonym: "Myristoyl" RELATED PSI-MS-label []
synonym: "Myristoylation" EXACT DeltaMass-label []
synonym: "Myristoylation" RELATED Unimod-description []
synonym: "MyrRes" EXACT PSI-MOD-label []
xref: DiffAvg: "210.36"
xref: DiffFormula: "C 14 H 26 O 1"
xref: DiffMono: "210.198365"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:45"
is_a: MOD:00649 ! acylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00439
name: O-phospho-L-threonine with neutral loss of phosphate
def: "Covalent modification of a peptide or protein amino acid phosphorylated threonine with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "dPhosOPhosThr" EXACT PSI-MOD-label []
xref: DiffAvg: "-97.99"
xref: DiffFormula: "C 0 H -3 N 0 O -4 P -1"
xref: DiffMono: "-97.976895"
xref: Formula: "C 4 H 5 N 1 O 1"
xref: MassAvg: "83.09"
xref: MassMono: "83.037114"
xref: Origin: "MOD:00047"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:01151 ! phosphorylated residue with neutral loss of phosphate
relationship: derives_from MOD:00047 ! O-phospho-L-threonine

[Term]
id: MOD:00440
name: palmitoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a palmitoyl group." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 238
subset: PSI-MOD-slim
synonym: "Palmitoyl" RELATED PSI-MS-label []
synonym: "Palmitoylation" EXACT DeltaMass-label []
synonym: "Palmitoylation" RELATED Unimod-description []
synonym: "PamRes" EXACT PSI-MOD-label []
synonym: "Hexadecanoylated residue" EXACT PSI-MOD-alternate []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 O 1"
xref: DiffMono: "238.229666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00441
name: geranylgeranylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a geranylgeranyl group." [DeltaMass:0, PubMed:15609361, Unimod:48]
comment: From DeltaMass: Average Mass: 272
subset: PSI-MOD-slim
synonym: "Geranyl-geranyl" RELATED Unimod-description []
synonym: "GeranylGeranyl" RELATED PSI-MS-label []
synonym: "Geranylgeranylation" EXACT DeltaMass-label []
synonym: "GergerRes" EXACT PSI-MOD-label []
xref: DiffAvg: "272.48"
xref: DiffFormula: "C 20 H 32"
xref: DiffMono: "272.250401"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:48"
is_a: MOD:00703 ! isoprenylated residue

[Term]
id: MOD:00442
name: protonated omega-N,omega-N'-dimethylated L-arginine with secondary neutral loss of N,N'-carbodiimide
def: "Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N'-dimethylated L-arginine with secondary loss of an N,N'-carbodiimide molecular fragment." [PubMed:15835918, PubMed:18688235]
synonym: "dCDI-NNMe2+Arg" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 1 H 2 N 2 O 0"
xref: DiffMono: "42.021798"
xref: Formula: "C 7 H 14 N 2 O 1"
xref: MassAvg: "142.20"
xref: MassMono: "142.110613"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00431 ! modified residue with a secondary neutral loss
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00443
name: protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of N,N-dimethylamine
def: "Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of an N,N-dimethylamine molecular fragment." [PubMed:15835918, PubMed:18688235]
synonym: "dDMA-NoMe2+Arg" EXACT PSI-MOD-label []
xref: DiffAvg: "59.09"
xref: DiffFormula: "C 2 H 7 N 2"
xref: DiffMono: "59.060923"
xref: Formula: "C 6 H 10 N 3 O 1"
xref: MassAvg: "140.17"
xref: MassMono: "140.082387"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00431 ! modified residue with a secondary neutral loss
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00444
name: N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine
def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine." [OMSSA:118, PubMed:10356335, Unimod:51]
synonym: "N-acyl diglyceride cysteine" RELATED Unimod-description []
synonym: "ntermpeptripalmitatec" EXACT OMSSA-label []
synonym: "Tripalmitate" RELATED PSI-MS-label []
xref: DiffAvg: "789.32"
xref: DiffFormula: "C 51 H 96 O 5"
xref: DiffMono: "788.725776"
xref: Formula: "C 54 H 101 N 1 O 6 S 1"
xref: MassAvg: "892.46"
xref: MassMono: "891.734961"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:51"
is_a: MOD:00899 ! N-palmitoyl-S-diacylglycerol-L-cysteine
relationship: has_functional_parent MOD:01144 ! S-(sn-1-2,3-dipalmitoylglycerol)-L-cysteine

[Term]
id: MOD:00445
name: L-homoarginine
def: "A protein modification that effectively converts an L-lysine residue to L-homoarginine, such as reaction with O-methylisourea." [OMSSA:53, PubMed:11078590, PubMed:11085420, PubMed:11821862, Unimod:52]
subset: PSI-MOD-slim
synonym: "Guanidination" RELATED Unimod-description []
synonym: "guanidinationk" EXACT OMSSA-label []
synonym: "Guanidinyl" RELATED PSI-MS-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 1 H 2 N 2"
xref: DiffMono: "42.021798"
xref: Formula: "C 7 H 14 N 4 O 1"
xref: MassAvg: "170.22"
xref: MassMono: "170.116761"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:52"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00446
name: 4-hydroxynonenal adduct
def: "A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal." [PubMed:11327326, PubMed:15133838, Unimod:53]
comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG].
synonym: "4-hydroxynonenal (HNE)" RELATED Unimod-description []
synonym: "HNE" RELATED PSI-MS-label []
xref: DiffAvg: "156.22"
xref: DiffFormula: "C 9 H 16 O 2"
xref: DiffMono: "156.115030"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:53"
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00447
name: N-glucuronylated residue
def: "A protein modification that effectively results from forming an adduct with a glucuronic acid either through a carboxyl group amide or ester bond, or through C1-glycosylation." [DeltaMass:0, PubMed:7398618, Unimod:54#N-term]
subset: PSI-MOD-slim
synonym: "Glucuronyl" RELATED PSI-MS-label []
synonym: "N-Glucuronyl (N terminus)" EXACT DeltaMass-label []
synonym: "N-glucuronylation" RELATED Unimod-description []
xref: DiffAvg: "176.12"
xref: DiffFormula: "C 6 H 8 O 6"
xref: DiffMono: "176.032088"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:54"
is_a: MOD:00764 ! glycoconjugated residue

[Term]
id: MOD:00448
name: mono-N-acetylaminoglucosylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an N-acetylaminoglucose group through a glycosidic bond." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "GlcNAcRes" EXACT PSI-MOD-label []
synonym: "HexNAc" RELATED PSI-MS-label []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00733 ! N-acetylaminoglucosylated
is_a: MOD:01673 ! N-acetylaminohexosylated residue

[Term]
id: MOD:00449
name: acetate labeling reagent (N-term) (heavy form, +3amu)
def: "modification from Unimod Isotopic label" [PubMed:11857757, PubMed:11999733, PubMed:12175151, Unimod:56]
synonym: "Acetate labeling reagent (N-term & K) (heavy form, +3amu)" RELATED Unimod-description []
synonym: "Acetyl:2H(3)" RELATED PSI-MS-label []
xref: DiffAvg: "45.03"
xref: DiffFormula: "C 2 (1)H -1 (2)H 3 O 1"
xref: DiffMono: "45.029395"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:56"
is_a: MOD:01431 ! (2)H deuterium tagged reagent

[Term]
id: MOD:00450
name: acetate labeling reagent light form (K)
def: "OBSOLETE because this isotopic label from Unimod entry 57 is deprecated" [PubMed:11857757]
xref: DiffAvg: "42.01"
xref: DiffFormula: "C 2 (1)H 2 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:00451
name: alpha-amino propanoylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, Unimod:58#N-term]
synonym: "Propionate labeling reagent light form (N-term & K)" RELATED Unimod-description []
synonym: "Propionyl" RELATED PSI-MS-label []
xref: DiffAvg: "56.06"
xref: DiffFormula: "C 3 H 4 O 1"
xref: DiffMono: "56.026215"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:58"
is_a: MOD:01894 ! propanoylated residue

[Term]
id: MOD:00452
name: alpha-amino 3x(13)C-labeled propanoylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(13)C-labeled propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, Unimod:59#N-term]
synonym: "Propionate labeling reagent heavy form (+3amu), N-term & K" RELATED Unimod-description []
synonym: "Propionyl:13C(3)" RELATED PSI-MS-label []
xref: DiffAvg: "59.04"
xref: DiffFormula: "(13)C 3 H 4 O 1"
xref: DiffMono: "59.036279"
xref: Formula: "(12)C 6 (13)C 3 H 16 N 2 O 2"
xref: MassAvg: "187.13"
xref: MassMono: "187.131242"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:59"
relationship: derives_from MOD:00451 ! alpha-amino propanoylated residue
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01426 ! isotope tagged reagent derivatized residue


[Term]
id: MOD:00453
name: quaternary amine labeling reagent light form (N-term & K)
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent light form group." [PubMed:11857757, Unimod:60]
synonym: "GIST-Quat" RELATED PSI-MS-label []
synonym: "Quaternary amine labeling reagent light form (N-term & K)" RELATED Unimod-description []
xref: DiffAvg: "127.19"
xref: DiffFormula: "C 7 H 13 N 1 O 1"
xref: DiffMono: "127.099714"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:60"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00454
name: quaternary amine labeling reagent heavy form (+3amu) (N-term & K)
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+3amu) form group." [PubMed:11857757, Unimod:61]
synonym: "GIST-Quat:2H(3)" RELATED PSI-MS-label []
synonym: "Quaternary amine labeling reagent heavy (+3amu) form, N-term & K" RELATED Unimod-description []
xref: DiffAvg: "130.12"
xref: DiffFormula: "C 7 (1)H 10 (2)H 3 N 1 O 1"
xref: DiffMono: "130.118544"
xref: Formula: "C 13 (1)H 22 (2)H 3 N 3 O 2"
xref: MassAvg: "258.21"
xref: MassMono: "258.213507"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:61"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00455
name: quaternary amine labeling reagent heavy form (+6amu) (N-term & K)
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+6amu) form group." [PubMed:11857757, Unimod:62]
synonym: "GIST-Quat:2H(6)" RELATED PSI-MS-label []
synonym: "Quaternary amine labeling reagent heavy form (+6amu), N-term & K" RELATED Unimod-description []
xref: DiffAvg: "133.14"
xref: DiffFormula: "C 7 H 7 (2)H 6 N 1 O 1"
xref: DiffMono: "133.137375"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:62"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00456
name: quaternary amine labeling reagent heavy form (+9amu) (N-term & K)
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+9amu) form group." [PubMed:11857757, Unimod:63]
synonym: "GIST-Quat:2H(9)" RELATED PSI-MS-label []
synonym: "Quaternary amine labeling reagent heavy form (+9amu), N-term & K" RELATED Unimod-description []
xref: DiffAvg: "136.16"
xref: DiffFormula: "C 7 (1)H 4 (2)H 9 N 1 O 1"
xref: DiffMono: "136.156205"
xref: Formula: "C 13 (1)H 16 (2)H 9 N 3 O 2"
xref: MassAvg: "264.25"
xref: MassMono: "264.251168"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:63"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00457
name: 4x(12)C, 4x(1)H labeled alpha-amino succinylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a light succinyl group." [PubMed:11857757, PubMed:12175151, Unimod:64#N-term]
synonym: "Succinic anhydride labeling reagent light form (N-term)" RELATED Unimod-description []
synonym: "Succinyl" RELATED PSI-MS-label []
xref: DiffAvg: "100.03"
xref: DiffFormula: "(12)C 4 (1)H 4 O 3"
xref: DiffMono: "100.016044"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:64"
relationship: derives_from MOD:01029 ! succinylated residue
is_a: MOD:01696 ! alpha-amino acylated residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00458
name: 4x(2)H labeled alpha-amino succinylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(2)H labeled succinyl group." [PubMed:11857757, PubMed:12175151, Unimod:65#N-term]
synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term" RELATED Unimod-description []
synonym: "Succinyl:2H(4)" RELATED PSI-MS-label []
xref: DiffAvg: "104.04"
xref: DiffFormula: "C 4 (2)H 4 O 3"
xref: DiffMono: "104.041151"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:65"
relationship: derives_from MOD:01029 ! succinylated residue
is_a: MOD:01696 ! alpha-amino acylated residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00459
name: 4x(13)C labeled alpha-amino succinylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(13)C labeled succinyl group." [PubMed:11857757, PubMed:12175151, Unimod:66#N-term]
synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4C13), N-term & K" RELATED Unimod-description []
synonym: "Succinyl:13C(4)" RELATED PSI-MS-label []
xref: DiffAvg: "104.03"
xref: DiffFormula: "(13)C 4 H 4 O 3"
xref: DiffMono: "104.029463"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: TermSpec: "none"
xref: Unimod: "Unimod:66"
relationship: derives_from MOD:01029 ! succinylated residue
is_a: MOD:01696 ! alpha-amino acylated residue
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00460
name: L-cysteic acid (L-cysteine sulfonic acid)
def: "A protein modification that effectively trioxygenates an L-cysteine residue to L-cysteine sulfonic acid." [ChEBI:17285, DeltaMass:334, OMSSA:34, PubMed:14678012, PubMed:18306178, PubMed:19522542, PubMed:9252331, RESID:AA0556, Unimod:345#C]
comment: From DeltaMass: Notes:Treatment of cysteine by strongly oxidising reagents such as performic acid results in the complete oxidation of the sulphur atom. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure.
subset: PSI-MOD-slim
synonym: "(2R)-2-amino-3-sulfopropanoic acid" EXACT RESID-systematic []
synonym: "2-amino-2-carboxyethanesulfonic acid" EXACT RESID-alternate []
synonym: "2-azanyl-3-sulfopropanoic acid" EXACT RESID-alternate []
synonym: "3-sulfoalanine" EXACT RESID-alternate []
synonym: "Cya" EXACT DeltaMass-label []
synonym: "CysO3H" EXACT PSI-MOD-label []
synonym: "cysteic acid" EXACT RESID-alternate []
synonym: "Cysteic acid, oxidation of cysteine" EXACT DeltaMass-label []
synonym: "cysteicacidc" EXACT OMSSA-label []
synonym: "cysteine oxidation to cysteic acid" RELATED Unimod-description []
synonym: "cysteine sulphonic acid" EXACT RESID-alternate []
synonym: "L-cysteine sulfonic acid" EXACT RESID-name []
synonym: "Trioxidation" RELATED PSI-MS-label []
synonym: "MOD_RES Cysteine sulfonic acid (-SO3H)" EXACT UniProt-feature []
xref: DiffAvg: "48.00"
xref: DiffFormula: "C 0 H 0 N 0 O 3 S 0"
xref: DiffMono: "47.984744"
xref: Formula: "C 3 H 5 N 1 O 4 S 1"
xref: MassAvg: "151.14"
xref: MassMono: "150.993929"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:345"
xref: uniprot.ptm:PTM-0634
is_a: MOD:00708 ! sulfur oxygenated L-cysteine

[Term]
id: MOD:00461
name: nitrated residue
def: "A protein modification that effectively substitutes a nitrite (NO2) group for a hydrogen atom." [DeltaMass:0, PubMed:8839040, PubMed:9252331, Unimod:354]
comment: Note, this is often misrepresented as the introduction of a nitrate (NO3) group [JSG].
subset: PSI-MOD-slim
synonym: "Nitro" RELATED PSI-MS-label []
synonym: "Nitro (NO2)" EXACT DeltaMass-label []
synonym: "Oxidation to nitro" RELATED Unimod-description []
xref: DiffAvg: "45.00"
xref: DiffFormula: "H -1 N 1 O 2"
xref: DiffMono: "44.985078"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: TermSpec: "none"
xref: Unimod: "Unimod:354"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00462
name: L-kynurenine
def: "A protein modification that effectively converts an L-tryptophan residue to L-kynurenine." [DeltaMass:357, OMSSA:66, PubMed:11029593, PubMed:9252331, Unimod:351#W]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-4-(2-aminophenyl)-4-oxo-butanoic acid" EXACT PSI-MOD-alternate []
synonym: "kynureninw" EXACT OMSSA-label []
synonym: "Trp->Kynurenin" RELATED PSI-MS-label []
synonym: "tryptophan oxidation to kynurenin" RELATED Unimod-description []
xref: DiffAvg: "3.99"
xref: DiffFormula: "C -1 O 1"
xref: DiffMono: "3.994915"
xref: Formula: "C 10 H 10 N 2 O 2"
xref: MassAvg: "190.20"
xref: MassMono: "190.074228"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:351"
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:00463
name: 3'-hydroxy-L-kynurenine
def: "A protein modification that effectively converts an L-tryptophan residue to 3'-hydroxy-L-kynurenine." [OMSSA:58, PubMed:9252331, Unimod:350#W]
subset: PSI-MOD-slim
synonym: "hydroxykynureninw" EXACT OMSSA-label []
synonym: "Trp->Hydroxykynurenin" RELATED PSI-MS-label []
synonym: "tryptophan oxidation to hydroxykynurenin" RELATED Unimod-description []
xref: DiffAvg: "19.99"
xref: DiffFormula: "C -1 O 2"
xref: DiffMono: "19.989829"
xref: Formula: "C 10 H 10 N 2 O 3"
xref: MassAvg: "206.20"
xref: MassMono: "206.069142"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:350"
is_a: MOD:00679 ! carbon oxygenated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:00464
name: N'-formyl-L-kynurenine
def: "A protein modification that effectively converts an L-tryptophan residue to N'-formyl-L-kynurenine." [DeltaMass:356, OMSSA:45, PubMed:12124932, PubMed:12686488, PubMed:9252331, Unimod:425#W]
comment: From DeltaMass: References:Willy V. Bienvenut, Catherine Déon, Carla Pasquarello, Jennifer M. Campbell, Jean-Charles Sanchez, Marvin L. Vestal, Denis F. Hochstrasser Matrix-assisted laser desorption/ionization-tandemmass spectrometry with high resolution andsensitivity for identification and characterizationof proteins. Proteomics 2002, 2, 868-876 Notes: A double oxidation of tryptophan for which the N-formylkynurenine (+32) structure can be proposed. Many minor peaks accompanying the main peak might also be attributed to other oxidation products of the tryptophan such as kynurenine (+4), an unknown by-product found in all oxidized tryptophan patterns (+13), hydroxytryptophan (+16), 3-hydroxykynurenine (+20) and hydroxy-N-formylkynurenine (+48). See proposed structures at http://www.abrf.org/images/misc/dmass32.jpg.
subset: PSI-MOD-slim
synonym: "dihydroxy" RELATED Unimod-description []
synonym: "Dioxidation" RELATED PSI-MS-label []
synonym: "Double oxidation of Trp" EXACT DeltaMass-label []
synonym: "formylkynureninw" EXACT OMSSA-label []
synonym: "tryptophan oxidation to formylkynurenin" RELATED Unimod-alternate []
xref: DiffAvg: "32.00"
xref: DiffFormula: "O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 11 H 10 N 2 O 3"
xref: MassAvg: "218.21"
xref: MassMono: "218.069142"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:425"
is_a: MOD:00679 ! carbon oxygenated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:00465
name: dihydroxyphenylalanine (Phe)
def: "A protein modification that effectively converts an L-phenylalanine residue to a dihydroxyphenylalanine." [OMSSA:39, PubMed:1610822, PubMed:1903612, PubMed:3734192, PubMed:9252331, RESID:AA0146#var, Unimod:425#F]
comment: Dihydroxyphenyalanines with a 4'-hydroxyl orginate naturally by a monohydroxylation of tyrosine, and not by dihydroxylation of phenylalanine [JSG].
subset: PSI-MOD-slim
synonym: "dihydroxy" RELATED Unimod-description []
synonym: "dihydroxyf" EXACT OMSSA-label []
synonym: "Dioxidation" RELATED PSI-MS-label []
xref: DiffAvg: "32.00"
xref: DiffFormula: "O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 9 H 9 N 1 O 3"
xref: MassAvg: "179.17"
xref: MassMono: "179.058243"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:425"
is_a: MOD:00428 ! dihydroxylated residue
is_a: MOD:00914 ! modified L-phenylalanine residue

[Term]
id: MOD:00466
name: glycosylsphingolipidinositolated residue
def: "A protein modification that effectively converts a residue to a glycosylsphingolipidinositolethanolamidated." [PubMed:12626404, PubMed:18688235, PubMed:8404891]
synonym: "GSIRes" EXACT PSI-MOD-label []
is_a: MOD:00764 ! glycoconjugated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00467
name: iminobiotinyl modified residue
def: "A protein modification that effectively substitutes an iminobiotinyl group for a hydrogen atom." [PubMed:9750125, Unimod:89]
synonym: "Iminobiotin" RELATED PSI-MS-label []
synonym: "Iminobiotinylation" RELATED Unimod-description []
xref: DiffAvg: "225.31"
xref: DiffFormula: "C 10 H 15 N 3 O 1 S 1"
xref: DiffMono: "225.093583"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:89"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00468
name: ESP-Tag light d0
def: "modification from Unimod Isotopic label" [Unimod:90]
synonym: "ESP" RELATED PSI-MS-label []
synonym: "ESP-Tag light d0" RELATED Unimod-description []
xref: DiffAvg: "338.47"
xref: DiffFormula: "C 16 H 26 N 4 O 2 S 1"
xref: DiffMono: "338.177647"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:90"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00469
name: ESP-Tag heavy d10
def: "modification from Unimod Isotopic label" [Unimod:91]
synonym: "ESP-Tag heavy d10" RELATED Unimod-description []
synonym: "ESP:2H(10)" RELATED PSI-MS-label []
xref: DiffAvg: "348.24"
xref: DiffFormula: "C 16 (1)H 16 (2)H 10 N 4 O 2 S 1"
xref: DiffMono: "348.240415"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:91"
is_a: MOD:01431 ! (2)H deuterium tagged reagent

[Term]
id: MOD:00470
name: NHS-LC-Biotin
def: "modification from Unimod Chemical derivative" [Unimod:92]
synonym: "NHS-LC-Biotin" RELATED Unimod-interim []
synonym: "NHS-LC-Biotin" RELATED Unimod-description []
xref: DiffAvg: "339.45"
xref: DiffFormula: "C 16 H 25 N 3 O 3 S 1"
xref: DiffMono: "339.161663"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:92"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00471
name: EDT-maleimide-PEO-biotin
def: "modification from Unimod Chemical derivative" [Unimod:93]
synonym: "EDT-maleimide-PEO-biotin" RELATED Unimod-interim []
synonym: "EDT-maleimide-PEO-biotin" RELATED Unimod-description []
xref: DiffAvg: "601.80"
xref: DiffFormula: "C 25 H 39 N 5 O 6 S 3"
xref: DiffMono: "601.206247"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:93"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00472
name: IMID d0
def: "modification from Unimod Isotopic label" [PubMed:11746907, Unimod:94, URL:http\://dx.doi.org/10.1002/rcm.517]
synonym: "IMID" RELATED PSI-MS-label []
synonym: "IMID d0" RELATED Unimod-description []
xref: DiffAvg: "68.04"
xref: DiffFormula: "C 3 (1)H 4 N 2"
xref: DiffMono: "68.037448"
xref: Formula: "C 9 H 16 N 4 O 1"
xref: MassAvg: "196.13"
xref: MassMono: "196.132411"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:94"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00473
name: IMID d4
def: "modification from Unimod Isotopic label" [PubMed:11746907, Unimod:95, URL:http\://dx.doi.org/10.1002/rcm.517]
synonym: "IMID d4" RELATED Unimod-description []
synonym: "IMID:2H(4)" RELATED PSI-MS-label []
xref: DiffAvg: "72.06"
xref: DiffFormula: "C 3 (2)H 4 N 2"
xref: DiffMono: "72.062555"
xref: Formula: "C 9 (1)H 12 (2)H 4 N 4 O 1"
xref: MassAvg: "200.16"
xref: MassMono: "200.157518"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:95"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00474
name: S-([1,1,2-(2)H3]-carboxamidoethyl)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(1,1,2-(2)H3)-propanamide-L-cysteine." [Unimod:97#C]
synonym: "Acrylamide d3" RELATED Unimod-description []
synonym: "Propionamide:2H(3)" RELATED PSI-MS-label []
synonym: "S-([1,1,2-(2)H3]-3-amino-3-oxopropyl)cysteine" EXACT PSI-MOD-alternate []
synonym: "S-([1,1,2-(2)H3]-carbamoylethyl)-L-cysteine" EXACT PSI-MOD-alternate []
synonym: "S-([1,1,2-(2)H3]-propanamide)-L-cysteine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "74.06"
xref: DiffFormula: "C 3 (1)H 2 (2)H 3 N 1 O 1"
xref: DiffMono: "74.055944"
xref: Formula: "C 6 (1)H 7 (2)H 3 N 2 O 2 S 1"
xref: MassAvg: "177.07"
xref: MassMono: "177.065129"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:97"
relationship: derives_from MOD:00417 ! S-carboxamidoethyl-L-cysteine
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00475
name: 2-amino-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to 2-amino-L-tyrosine." [PubMed:8839040, PubMed:9252331, Unimod:342#Y]
synonym: "Amino" RELATED PSI-MS-label []
synonym: "Tyrosine oxidation to 2-aminotyrosine" RELATED Unimod-description []
xref: DiffAvg: "15.02"
xref: DiffFormula: "H 1 N 1"
xref: DiffMono: "15.010899"
xref: Formula: "C 9 H 10 N 2 O 2"
xref: MassAvg: "178.19"
xref: MassMono: "178.074228"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:342"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:02039 ! aminated residue

[Term]
id: MOD:00476
name: monogalactosylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an galactose group through a glycosidic bond." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "GalRes" EXACT PSI-MOD-label []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00761 ! monohexosylated residue
is_a: MOD:00728 ! galactosylated residue

[Term]
id: MOD:00477
name: 2-pyrrolidone
def: "A protein modification that effectively converts, by oxidative decarboxylation, an L-proline residue to 2-pyrrolidone with breakage of the peptide chain." [PubMed:2161657, PubMed:9252331, Unimod:360#P]
comment: The oxidative decarboxylation of a proline residue results in breaking of the peptide chain, leaving a peptidyl-2-pyrrolidone at the C-terminus. The difference formula, derived from the result in the original citation, has been corrected from the Unimod entry.
synonym: "Pro->Pyrrolidinone" RELATED PSI-MS-label []
synonym: "Proline oxidation to pyrrolidinone" RELATED Unimod-description []
xref: DiffAvg: "-13.02"
xref: DiffFormula: "C -1 H -1 N 0 O 0"
xref: DiffMono: "-13.007825"
xref: Formula: "C 4 H 6 N 1 O 1"
xref: MassAvg: "84.10"
xref: MassMono: "84.044939"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:360"
is_a: MOD:00683 ! dehydrogenated residue
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:00478
name: glutamyl semialdehyde (Pro)
def: "A protein modification that effectively converts an L-proline residue to L-glutamyl semialdehyde." [DeltaMass:354, PubMed:11120890, PubMed:2563380, PubMed:9252331, Unimod:35#P]
synonym: "gamma-glutamyl semialdehyde" EXACT PSI-MOD-alternate []
synonym: "glutamyl 5-semialdehyde" EXACT PSI-MOD-alternate []
synonym: "glutamyl aldehyde" EXACT PSI-MOD-alternate []
synonym: "Oxidation" RELATED Unimod-interim []
synonym: "Oxidation of proline to gamma-glutamyl semialdehyde" EXACT DeltaMass-label []
synonym: "Oxidation or Hydroxylation" RELATED Unimod-description []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 7 N 1 O 2"
xref: MassAvg: "113.12"
xref: MassMono: "113.047678"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:35"
is_a: MOD:00679 ! carbon oxygenated residue
is_a: MOD:00915 ! modified L-proline residue
is_a: MOD:01440 ! glutamyl semialdehyde

[Term]
id: MOD:00479
name: glutamyl semialdehyde (Arg)
def: "A protein modification that effectively converts an L-arginine residue to L-glutamyl semialdehyde." [DeltaMass:351, PubMed:11120890, PubMed:1680314, PubMed:9252331, Unimod:344#R]
comment: From DeltaMass: Average Mass: -27 Monoisotopic Mass Change:-27.06 Average Mass Change:-27.07 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001.
synonym: "Arg->GluSA" RELATED PSI-MS-label []
synonym: "Arginine oxidation to glutamic semialdehyde" RELATED Unimod-description []
synonym: "Oxidation of arginine (to glutamic acid)" EXACT DeltaMass-label []
xref: DiffAvg: "-43.07"
xref: DiffFormula: "C -1 H -5 N -3 O 1"
xref: DiffMono: "-43.053433"
xref: Formula: "C 5 H 7 N 1 O 2"
xref: MassAvg: "113.12"
xref: MassMono: "113.047678"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:344"
is_a: MOD:00902 ! modified L-arginine residue
is_a: MOD:01440 ! glutamyl semialdehyde

[Term]
id: MOD:00480
name: Applied Biosystems cleavable ICAT(TM) light
def: "modification from Unimod Isotopic label" [OMSSA:129, Unimod:105#C, URL:http\://www.appliedbiosystems.com/products/productdetail.cfm?prod_id=153]
subset: PSI-MOD-slim
synonym: "Applied Biosystems cleavable ICAT(TM) light" RELATED Unimod-description []
synonym: "ICAT-C" RELATED PSI-MS-label []
synonym: "icatlight" EXACT OMSSA-label []
xref: DiffAvg: "227.26"
xref: DiffFormula: "C 10 H 17 N 3 O 3"
xref: DiffMono: "227.126991"
xref: Formula: "C 13 H 22 N 4 O 4 S 1"
xref: MassAvg: "330.40"
xref: MassMono: "330.136176"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:105"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00481
name: Applied Biosystems cleavable ICAT(TM) heavy
def: "modification from Unimod Isotopic label" [OMSSA:130, Unimod:106#C, URL:http\://www.appliedbiosystems.com/products/productdetail.cfm?prod_id=153]
subset: PSI-MOD-slim
synonym: "Applied Biosystems cleavable ICAT(TM) heavy" RELATED Unimod-description []
synonym: "ICAT-C:13C(9)" RELATED PSI-MS-label []
synonym: "icatheavy" EXACT OMSSA-label []
xref: DiffAvg: "236.16"
xref: DiffFormula: "(12)C 1 (13)C 9 H 17 N 3 O 3"
xref: DiffMono: "236.157185"
xref: Formula: "(12)C 4 (13)C 9 H 22 N 4 O 4 S 1"
xref: MassAvg: "339.17"
xref: MassMono: "339.166370"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:106"
is_a: MOD:01428 ! (13)C isotope tagged reagent

[Term]
id: MOD:00482
name: N-formyl-L-methionine (Met)
def: "A protein modification that effectively converts an L-methionine residue to N-formyl-L-methionine (not known as a natural, post-translational modification process)." [PubMed:11152118, PubMed:2165784, PubMed:3042771, Unimod:122#M, RESID:AA0021#MET]
comment: This entry is for the artifactual formation of N-formyl-L-methionine from methionine. For encoded N-formyl-L-methionine, use MOD:00030 [JSG].
synonym: "(2S)-2-formylamino-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "2-formamido-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate []
synonym: "2-formylamino-4-(methylthio)butanoic acid" EXACT RESID-alternate []
synonym: "2-formylazanyl-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate []
synonym: "MOD_RES N-formylmethionine" EXACT UniProt-feature []
synonym: "N-formyl-L-methionine" EXACT RESID-name []
synonym: "N-formylated L-methionine" EXACT PSI-MOD-alternate []
synonym: "NFoMet" EXACT PSI-MOD-label []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 H 0 N 0 O 1 S 0"
xref: DiffMono: "27.994915"
xref: Formula: "C 6 H 10 N 1 O 2 S 1"
xref: MassAvg: "160.21"
xref: MassMono: "160.043225"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:122"
xref: uniprot.ptm:PTM-0212
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:00483
name: N-ethylmaleimide derivatized cysteine
def: "A protein modification that is produced by reaction with N-ethylmaleimide." [OMSSA:83, PubMed:11813307, PubMed:12777388, Unimod:108#C]
synonym: "N-ethylmaleimide on cysteines" RELATED Unimod-description []
synonym: "nemc" EXACT OMSSA-label []
synonym: "Nethylmaleimide" RELATED PSI-MS-label []
xref: DiffAvg: "125.13"
xref: DiffFormula: "C 6 H 7 N 1 O 2"
xref: DiffMono: "125.047678"
xref: Formula: "C 9 H 12 N 2 O 3 S 1"
xref: MassAvg: "228.27"
xref: MassMono: "228.056863"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:108"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00484
name: oxidized lysine biotinylated with biotin-LC-hydrazide, reduced
def: "modification from Unimod Chemical derivative" [Unimod:112#K]
synonym: "Oxidized lysine biotinylated with biotin-LC-hydrazide, reduced" RELATED Unimod-description []
synonym: "OxLysBiotinRed" RELATED Unimod-interim []
xref: DiffAvg: "354.47"
xref: DiffFormula: "C 16 H 26 N 4 O 3 S 1"
xref: DiffMono: "354.172562"
xref: Formula: "C 22 H 38 N 6 O 4 S 1"
xref: MassAvg: "482.64"
xref: MassMono: "482.267525"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:112"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00485
name: oxidized lysine biotinylated with biotin-LC-hydrazide
def: "modification from Unimod Chemical derivative" [Unimod:113#K]
synonym: "Oxidized lysine biotinylated with biotin-LC-hydrazide" RELATED Unimod-description []
synonym: "OxLysBiotin" RELATED Unimod-interim []
xref: DiffAvg: "352.45"
xref: DiffFormula: "C 16 H 24 N 4 O 3 S 1"
xref: DiffMono: "352.156912"
xref: Formula: "C 22 H 36 N 6 O 4 S 1"
xref: MassAvg: "480.63"
xref: MassMono: "480.251875"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:113"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00486
name: oxidized proline biotinylated with biotin-LC-hydrazide, reduced
def: "modification from Unimod Chemical derivative" [Unimod:114#C]
synonym: "Oxidized proline biotinylated with biotin-LC-hydrazide, reduced" RELATED Unimod-description []
synonym: "OxProBiotinRed" RELATED Unimod-interim []
xref: DiffAvg: "371.50"
xref: DiffFormula: "C 16 H 29 N 5 O 3 S 1"
xref: DiffMono: "371.199111"
xref: Formula: "C 21 H 36 N 6 O 4 S 1"
xref: MassAvg: "468.62"
xref: MassMono: "468.251875"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:114"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:00487
name: oxidized proline biotinylated with biotin-LC-hydrazide
def: "modification from Unimod Chemical derivative" [Unimod:115#C]
synonym: "Oxidized Proline biotinylated with biotin-LC-hydrazide" RELATED Unimod-description []
synonym: "OxProBiotin" RELATED Unimod-interim []
xref: DiffAvg: "369.48"
xref: DiffFormula: "C 16 H 27 N 5 O 3 S 1"
xref: DiffMono: "369.183461"
xref: Formula: "C 21 H 34 N 6 O 4 S 1"
xref: MassAvg: "466.60"
xref: MassMono: "466.236225"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:115"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:00488
name: oxidized arginine biotinylated with biotin-LC-hydrazide
def: "modification from Unimod Chemical derivative" [Unimod:116#C]
synonym: "OxArgBiotin" RELATED Unimod-interim []
synonym: "Oxidized arginine biotinylated with biotin-LC-hydrazide" RELATED Unimod-description []
xref: DiffAvg: "310.41"
xref: DiffFormula: "C 15 H 22 N 2 O 3 S 1"
xref: DiffMono: "310.135114"
xref: Formula: "C 21 H 34 N 6 O 4 S 1"
xref: MassAvg: "466.60"
xref: MassMono: "466.236225"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00489
name: oxidized arginine biotinylated with biotin-LC-hydrazide, reduced
def: "modification from Unimod Chemical derivative" [Unimod:117#C]
synonym: "OxArgBiotinRed" RELATED Unimod-interim []
synonym: "Oxidized arginine biotinylated with biotin-LC-hydrazide, reduced" RELATED Unimod-description []
xref: DiffAvg: "312.43"
xref: DiffFormula: "C 15 H 24 N 2 O 3 S 1"
xref: DiffMono: "312.150764"
xref: Formula: "C 21 H 36 N 6 O 4 S 1"
xref: MassAvg: "468.62"
xref: MassMono: "468.251875"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:117"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00490
name: EDT-iodo-PEO-biotin
def: "modification from Unimod Chemical derivative" [Unimod:118]
synonym: "EDT-iodo-PEO-biotin" RELATED Unimod-description []
synonym: "EDT-iodoacetyl-PEO-biotin" RELATED PSI-MS-label []
xref: DiffAvg: "490.70"
xref: DiffFormula: "C 20 H 34 N 4 O 4 S 3"
xref: DiffMono: "490.174219"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: TermSpec: "none"
xref: Unimod: "Unimod:118"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00491
name: thio ether formation - BTP Adduct
def: "modification from Unimod Chemical derivative" [PubMed:11861642, Unimod:119#C]
synonym: "IBTP" RELATED PSI-MS-label []
synonym: "Thio Ether Formation - BTP Adduct" RELATED Unimod-description []
xref: DiffAvg: "316.38"
xref: DiffFormula: "C 22 H 21 P 1"
xref: DiffMono: "316.138087"
xref: Formula: "C 25 H 26 N 1 O 1 P 1 S 1"
xref: MassAvg: "419.52"
xref: MassMono: "419.147272"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:119"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00492
name: ubiquitination signature dipeptidyl lysine
def: "A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of glycylglycine, the two glycine residues left after tryptic digestion of ubiquitin." [OMSSA:52, PubMed:11125103, PubMed:12612601, PubMed:12872131, RESID:AA0125#var, Unimod:121#K]
synonym: "GlyGly" RELATED PSI-MS-label []
synonym: "glyglyk" EXACT OMSSA-label []
synonym: "N6-(glycylglycyl)lysine" EXACT PSI-MOD-alternate []
synonym: "N6-glycylglycyl-L-lysine" EXACT PSI-MOD-alternate []
synonym: "ubiquitinylation residue" RELATED Unimod-description []
xref: DiffAvg: "114.10"
xref: DiffFormula: "C 4 H 6 N 2 O 2"
xref: DiffMono: "114.042927"
xref: Formula: "C 10 H 18 N 4 O 3"
xref: MassAvg: "242.28"
xref: MassMono: "242.137890"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:121"
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01875 ! N6-acylated L-lysine
relationship: derives_from MOD:01148 ! ubiquitinylated lysine

[Term]
id: MOD:00493
name: formylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a formyl group." [DeltaMass:0, PubMed:15799070, Unimod:122]
comment: From DeltaMass: Average Mass: 28
subset: PSI-MOD-slim
synonym: "FoRes" EXACT PSI-MOD-label []
synonym: "Formyl" RELATED PSI-MS-label []
synonym: "Formylation" RELATED Unimod-description []
synonym: "Formylation (CHO)" EXACT DeltaMass-label []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: TermSpec: "none"
xref: Unimod: "Unimod:122"
is_a: MOD:00649 ! acylated residue

[Term]
id: MOD:00494
name: N-iodoacetyl, p-chlorobenzyl-12C6-glucamine
def: "modification from Unimod Isotopic label" [PubMed:12185208, Unimod:123#C]
synonym: "ICAT-H" RELATED PSI-MS-label []
synonym: "N-iodoacetyl, p-chlorobenzyl-12C6-glucamine" RELATED Unimod-description []
xref: DiffAvg: "345.78"
xref: DiffFormula: "C 15 Cl 1 H 20 N 1 O 6 S 0"
xref: DiffMono: "345.097915"
xref: Formula: "C 18 Cl 1 H 25 N 2 O 7 S 1"
xref: MassAvg: "448.91"
xref: MassMono: "448.107100"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:123"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00495
name: N-iodoacetyl, p-chlorobenzyl-13C6-glucamine
def: "modification from Unimod Isotopic label" [PubMed:12185208, Unimod:124#C]
synonym: "ICAT-H:13C(6)" RELATED PSI-MS-label []
synonym: "N-iodoacetyl, p-chlorobenzyl-13C6-glucamine" RELATED Unimod-description []
xref: DiffAvg: "351.12"
xref: DiffFormula: "(12)C 9 (13)C 6 Cl 1 H 20 N 1 O 6 S 0"
xref: DiffMono: "351.118044"
xref: Formula: "(12)C 12 (13)C 6 Cl 1 H 25 N 2 O 7 S 1"
xref: MassAvg: "454.13"
xref: MassMono: "454.127229"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:124"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00496
name: reductive amination-D
def: "OBSOLETE because Unimod entry 125 is merged with entry 199, remap to id: MOD:00552" [Unimod:125]
xref: DiffAvg: "32.06"
xref: DiffFormula: "C 2 (2)H 4"
xref: DiffMono: "32.056407"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00552"
xref: Unimod: "Unimod:125"
is_obsolete: true

[Term]
id: MOD:00497
name: 3-sulfanylpropanoyl (N-term and Lys)
def: "modification from Unimod [(35)S]dithiobis(succinimidyl propionate) crosslinking" [PubMed:957432, Unimod:126]
comment: The name "thioacylation of primary amines" in Unimod was a misdescription [JSG].
synonym: "3,3-Dithio-bis-(sulfosuccinimidyl)propionate" RELATED Unimod-alternate []
synonym: "3-sulfanylpropanoyl" RELATED Unimod-description []
synonym: "Thioacyl" RELATED PSI-MS-label []
xref: DiffAvg: "88.12"
xref: DiffFormula: "C 3 H 4 O 1 S 1"
xref: DiffMono: "87.998286"
xref: Formula: "C 9 H 16 N 2 O 2 S 1"
xref: MassAvg: "216.30"
xref: MassMono: "216.093249"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:126"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00498
name: fluorinated residue
def: "A protein modification that effectively substitutes a hydrogen of a residue with a fluorine atom." [PubMed:18688235]
synonym: "Fluoro" RELATED PSI-MS-label []
synonym: "fluorophenylalanine replacement of phenylalanine" RELATED Unimod-description []
synonym: "Fluorophenylalanyl" EXACT DeltaMass-label []
synonym: "FRes" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00694 ! halogen containing residue

[Term]
id: MOD:00499
name: 5-iodoacetamidofluorescein
def: "modification from Unimod Chemical derivative" [PubMed:3311742, PubMed:3578767, Unimod:128#C]
synonym: "5-Iodoacetamidofluorescein (Molecular Probe, Eugene, OR)" RELATED Unimod-description []
synonym: "Fluorescein" RELATED PSI-MS-label []
xref: DiffAvg: "388.35"
xref: DiffFormula: "C 22 H 14 N 1 O 6"
xref: DiffMono: "388.082112"
xref: Formula: "C 25 H 19 N 2 O 7 S 1"
xref: MassAvg: "491.49"
xref: MassMono: "491.091297"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:128"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00500
name: monoiodinated residue
def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one iodine atom." [DeltaMass:0, PubMed:15627961, PubMed:2026710, Unimod:129]
comment: From DeltaMass: Average Mass: 126
subset: PSI-MOD-slim
synonym: "I1Res" EXACT PSI-MOD-label []
synonym: "Iodination" RELATED Unimod-description []
synonym: "Iodination (of Histidine[C4] or Tyrosine[C3])" EXACT DeltaMass-label []
synonym: "Iodo" RELATED PSI-MS-label []
xref: DiffAvg: "125.90"
xref: DiffFormula: "H -1 I 1"
xref: DiffMono: "125.896648"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: TermSpec: "none"
xref: Unimod: "Unimod:129"
is_a: MOD:00755 ! iodinated residue

[Term]
id: MOD:00501
name: diiodinated residue
def: "A protein modification that effectively substitutes two hydrogen atoms of a residue with two iodine atoms." [Unimod:130]
comment: From DeltaMass: Average Mass: 252
subset: PSI-MOD-slim
synonym: "di-Iodination" RELATED Unimod-description []
synonym: "Diiodo" RELATED PSI-MS-label []
synonym: "I2Res" EXACT PSI-MOD-label []
xref: DiffAvg: "251.79"
xref: DiffFormula: "H -2 I 2"
xref: DiffMono: "251.793295"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: TermSpec: "none"
xref: Unimod: "Unimod:130"
is_a: MOD:00755 ! iodinated residue

[Term]
id: MOD:00502
name: triiodinated residue
def: "A protein modification that effectively substitutes three hydrogen atoms of a residue with three iodine atoms." [OMSSA:116, PubMed:15627961, PubMed:2026710, Unimod:131]
comment: From Unimod. In PubMed:2026710, mono- and diiodination of tyrosine are discussed, but triiodination of tyrosine is not mentioned. In PubMed:15627961, triiodothyronine (see MOD:00186) is discussed, but triiodotyrosine is not mentioned. This modification probably does not exist, and may be a confusion of "tyrosine" for "thyronine", a common error [JSG].
subset: PSI-MOD-slim
synonym: "I3Res" EXACT PSI-MOD-label []
synonym: "tri-Iodination" RELATED Unimod-description []
synonym: "triiodinationy" EXACT OMSSA-label []
synonym: "Triiodo" RELATED PSI-MS-label []
xref: DiffAvg: "377.69"
xref: DiffFormula: "H -3 I 3"
xref: DiffMono: "377.689943"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:131"
is_a: MOD:00755 ! iodinated residue

[Term]
id: MOD:00503
name: N-(cis-delta 5)-tetradecaenoylglycine
def: "A protein modification that effectively converts a glycine residue to N-(cis-delta 5)-tetradecaenoylglycine." [OMSSA:78, PubMed:11955007, PubMed:11955008, PubMed:1326520, PubMed:1386601, PubMed:6436247, PubMed:7543369, RESID:AA0059#var, Unimod:134#G]
synonym: "(cis-delta 5)-tetradecaenoyl" RELATED Unimod-description []
synonym: "Myristoleyl" RELATED PSI-MS-label []
synonym: "myristoleylation (one double bond)" EXACT DeltaMass-label []
synonym: "N-(C14:1 aliphatic acyl)glycine" EXACT PSI-MOD-alternate []
synonym: "ntermpepmyristoyeylationg" EXACT OMSSA-label []
xref: DiffAvg: "208.35"
xref: DiffFormula: "C 14 H 24 N 0 O 1"
xref: DiffMono: "208.182715"
xref: Formula: "C 16 H 27 N 1 O 2"
xref: MassAvg: "265.40"
xref: MassMono: "265.204179"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:134"
is_a: MOD:00908 ! modified glycine residue
is_a: MOD:01696 ! alpha-amino acylated residue

[Term]
id: MOD:00504
name: N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine
def: "A protein modification that effectively converts a glycine residue to N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine." [OMSSA:79, PubMed:11955007, PubMed:11955008, PubMed:1326520, PubMed:1386601, PubMed:6436247, PubMed:7543369, RESID:AA0059#var, Unimod:135#G]
synonym: "(cis,cis-delta 5, delta 8)-tetradecadienoyl" RELATED Unimod-description []
synonym: "Myristoyl+Delta:H(-4)" RELATED PSI-MS-label []
synonym: "myristoylation-4H (two double bonds)" EXACT DeltaMass-label []
synonym: "N-(C14:2 aliphatic acyl)glycine" EXACT PSI-MOD-alternate []
synonym: "ntermpepmyristoyl4hg" EXACT OMSSA-label []
xref: DiffAvg: "206.33"
xref: DiffFormula: "C 14 H 22 O 1"
xref: DiffMono: "206.167065"
xref: Formula: "C 16 H 25 N 1 O 2"
xref: MassAvg: "263.38"
xref: MassMono: "263.188529"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:135"
is_a: MOD:00908 ! modified glycine residue
is_a: MOD:01696 ! alpha-amino acylated residue

[Term]
id: MOD:00505
name: benzoyl labeling reagent light form (N-term and K)
def: "modification from Unimod Isotopic label" [DeltaMass:0, PubMed:15456300, Unimod:136]
comment: From DeltaMass: Average Mass: 104
synonym: "Benzoyl" RELATED PSI-MS-label []
synonym: "Benzoyl (Bz)" EXACT DeltaMass-label []
synonym: "labeling reagent light form (N-term & K)" RELATED Unimod-description []
xref: DiffAvg: "104.11"
xref: DiffFormula: "C 7 H 4 O 1"
xref: DiffMono: "104.026215"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:136"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00506
name: N-linked glycan core N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, Hex(5) HexNAc(2)" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, Unimod:137#N]
synonym: "Hex(5)HexNAc(2)" RELATED PSI-MS-label []
synonym: "N-linked glycan core" RELATED Unimod-description []
xref: DiffAvg: "1217.09"
xref: DiffFormula: "C 46 H 76 N 2 O 35"
xref: DiffMono: "1216.422862"
xref: Formula: "C 50 H 82 N 4 O 37"
xref: MassAvg: "1331.20"
xref: MassMono: "1330.465790"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:137"
xref: GNOme: "GNO:G02815KT"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00507
name: 5-dimethylaminonaphthalene-1-sulfonyl
def: "OBSOLETE because redundant, replaced by MOD:01653. Remap to MOD:01653." [DeltaMass:0, Unimod:139]
comment: From DeltaMass: Average Mass: 233
synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED Unimod-description []
synonym: "Dansyl" RELATED PSI-MS-label []
synonym: "Dansyl (Dns)" EXACT DeltaMass-label []
xref: DiffAvg: "233.29"
xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1"
xref: DiffMono: "233.051050"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:139"
xref: Remap: "MOD:01653"
is_obsolete: true

[Term]
id: MOD:00508
name: ISD a-series (C-Term)
def: "OBSOLETE because this is an ion type and is not a biological or chemical modification to a polypeptide, can be handled by PSI-MS CV term, MS:1001229" [PubMed:14588022, Unimod:140]
comment: Virtual Modification for MS/MS of a-type ions, by decarboxylation of C-terminus as reaction inside the mass spectrometer.
synonym: "a-type-ion" RELATED PSI-MS-label []
synonym: "ISD a-series (C-Term)" RELATED Unimod-description []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:140"
is_obsolete: true


[Term]
id: MOD:00509
name: amidination of lysines or N-terminal amines with methyl acetimidate
def: "modification from Unimod Chemical derivative" [PubMed:12643539, PubMed:6273432, Unimod:141]
synonym: "amidination of lysines or N-terminal amines with methyl acetimidate" RELATED Unimod-description []
synonym: "Amidine" RELATED PSI-MS-label []
xref: DiffAvg: "41.05"
xref: DiffFormula: "C 2 H 3 N 1"
xref: DiffMono: "41.026549"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:141"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00510
name: HexNAc1dHex1 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, dHex HexNAc" [OMSSA:183, PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, Unimod:142]
synonym: "dHexHexNAcN" EXACT OMSSA-label []
synonym: "HexNAc(1)dHex(1)" RELATED PSI-MS-label []
synonym: "HexNAc1dHex1" RELATED Unimod-description []
xref: DiffAvg: "349.34"
xref: DiffFormula: "C 14 H 23 N 1 O 9"
xref: DiffMono: "349.137281"
xref: Formula: "C 18 H 29 N 3 O 11"
xref: MassAvg: "463.44"
xref: MassMono: "463.180209"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:142"
xref: GNOme: "GNO:G00194GV"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00511
name: HexNAc2 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, HexNAc(2)" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, Unimod:143]
synonym: "HexNAc(2)" RELATED PSI-MS-label []
synonym: "HexNAc2" RELATED Unimod-description []
xref: DiffAvg: "406.39"
xref: DiffFormula: "C 16 H 26 N 2 O 10"
xref: DiffMono: "406.158745"
xref: Formula: "C 20 H 32 N 4 O 12"
xref: MassAvg: "520.49"
xref: MassMono: "520.201672"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:143"
xref: GNOme: "GNO:G27391WQ"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00512
name: Hex3 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, Hex3" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, Unimod:144]
synonym: "Hex(3)" RELATED PSI-MS-label []
synonym: "Hex3" RELATED Unimod-description []
xref: DiffAvg: "486.42"
xref: DiffFormula: "C 18 H 30 O 15"
xref: DiffMono: "486.158470"
xref: Formula: "C 22 H 36 N 2 O 17"
xref: MassAvg: "600.53"
xref: MassMono: "600.201398"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:144"
xref: GNOme: "GNO:G39365VM"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00513
name: HexNAc1dHex2 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, dHex(2) HexNAc" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, Unimod:145]
synonym: "HexNAc(1)dHex(2)" RELATED PSI-MS-label []
synonym: "HexNAc1dHex2" RELATED Unimod-description []
xref: DiffAvg: "495.48"
xref: DiffFormula: "C 20 H 33 N 1 O 13"
xref: DiffMono: "495.195190"
xref: Formula: "C 24 H 39 N 3 O 15"
xref: MassAvg: "609.58"
xref: MassMono: "609.238118"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:145"
xref: GNOme: "GNO:G74392IM"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00514
name: Hex1HexNAc1dHex1 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, dHex Hex HexNAc" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, Unimod:146]
synonym: "Hex(1)HexNAc(1)dHex(1)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc1dHex1" RELATED Unimod-description []
xref: DiffAvg: "511.48"
xref: DiffFormula: "C 20 H 33 N 1 O 14"
xref: DiffMono: "511.190105"
xref: Formula: "C 24 H 39 N 3 O 16"
xref: MassAvg: "625.58"
xref: MassMono: "625.233032"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:146"
xref: GNOme: "GNO:G54129SE"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00515
name: HexNAc2dHex1 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, dHex HexNAc(2)" [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var, Unimod:147]
synonym: "HexNAc(2)dHex(1)" RELATED PSI-MS-label []
synonym: "HexNAc2dHex1" RELATED Unimod-description []
xref: DiffAvg: "552.53"
xref: DiffFormula: "C 22 H 36 N 2 O 14"
xref: DiffMono: "552.216654"
xref: Formula: "C 26 H 42 N 4 O 16"
xref: MassAvg: "666.63"
xref: MassMono: "666.259581"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:147"
xref: GNOme: "GNO:G06042JP"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00516
name: Hex1HexNAc2 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [RESID:AA0151#var, Unimod:148]
synonym: "Hex(1)HexNAc(2)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc2" RELATED Unimod-description []
xref: DiffAvg: "568.53"
xref: DiffFormula: "C 22 H 36 N 2 O 15"
xref: DiffMono: "568.211568"
xref: Formula: "C 26 H 42 N 4 O 17"
xref: MassAvg: "682.63"
xref: MassMono: "682.254496"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:148"
xref: GNOme: "GNO:G58001LT"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00517
name: Hex1HexNAc1NeuAc1 glycosylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [DeltaMass:0, Unimod:149]
comment: From DeltaMass: Average Mass: 657
synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc1NeuAc1" RELATED Unimod-description []
synonym: "NeuAc-Hex-HexNAc" EXACT DeltaMass-label []
xref: DiffAvg: "657.60"
xref: DiffFormula: "C 25 H 41 N 2 O 18"
xref: DiffMono: "657.235437"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: GNOme: "GNO:G17015OC"
is_a: MOD:00725 ! complex glycosylation

[Term]
id: MOD:00518
name: HexNAc2dHex2 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [RESID:AA0151#var, Unimod:150]
synonym: "HexNAc(2)dHex(2)" RELATED PSI-MS-label []
synonym: "HexNAc2dHex2" RELATED Unimod-description []
xref: DiffAvg: "698.67"
xref: DiffFormula: "C 28 H 46 N 2 O 18"
xref: DiffMono: "698.274563"
xref: Formula: "C 32 H 52 N 4 O 20"
xref: MassAvg: "812.78"
xref: MassMono: "812.317490"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:150"
xref: GNOme: "GNO:G90423UY"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00519
name: Hex1HexNAc2Pent1 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [RESID:AA0151#var, Unimod:151]
synonym: "Hex(1)HexNAc(2)Pent(1)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc2Pent1" RELATED Unimod-description []
xref: DiffAvg: "700.64"
xref: DiffFormula: "C 27 H 44 N 2 O 19"
xref: DiffMono: "700.253827"
xref: Formula: "C 31 H 50 N 4 O 21"
xref: MassAvg: "814.75"
xref: MassMono: "814.296755"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:151"
xref: GNOme: "GNO:G54968WM"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00520
name: Hex1HexNAc2dHex1 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [RESID:AA0151#var, Unimod:152]
synonym: "Hex(1)HexNAc(2)dHex(1)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc2dHex1" RELATED Unimod-description []
xref: DiffAvg: "714.67"
xref: DiffFormula: "C 28 H 46 N 2 O 19"
xref: DiffMono: "714.269477"
xref: Formula: "C 32 H 52 N 4 O 21"
xref: MassAvg: "828.77"
xref: MassMono: "828.312405"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:152"
xref: GNOme: "GNO:G94583DZ"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00521
name: Hex2HexNAc2 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [RESID:AA0151#var, Unimod:153]
synonym: "Hex(2)HexNAc(2)" RELATED PSI-MS-label []
synonym: "Hex2HexNAc2" RELATED Unimod-description []
xref: DiffAvg: "730.67"
xref: DiffFormula: "C 28 H 46 N 2 O 20"
xref: DiffMono: "730.264392"
xref: Formula: "C 32 H 52 N 4 O 22"
xref: MassAvg: "844.77"
xref: MassMono: "844.307319"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:153"
xref: GNOme: "GNO:G53434XO"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00522
name: Hex3HexNAc1Pent1 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [RESID:AA0151#var, Unimod:154]
synonym: "Hex(3)HexNAc(1)Pent(1)" RELATED PSI-MS-label []
synonym: "Hex3HexNAc1Pent1" RELATED Unimod-description []
xref: DiffAvg: "821.73"
xref: DiffFormula: "C 31 H 51 N 1 O 24"
xref: DiffMono: "821.280102"
xref: Formula: "C 35 H 57 N 3 O 26"
xref: MassAvg: "935.84"
xref: MassMono: "935.323029"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:154"
xref: GNOme: "GNO:G64686LL"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00523
name: Hex1HexNAc2dHex1Pent1 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [RESID:AA0151#var, Unimod:155]
synonym: "Hex(1)HexNAc(2)dHex(1)Pent(1)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc2dHex1Pent1" RELATED Unimod-description []
xref: DiffAvg: "846.79"
xref: DiffFormula: "C 33 H 54 N 2 O 23"
xref: DiffMono: "846.311736"
xref: Formula: "C 35 H 57 N 3 O 26"
xref: MassAvg: "960.89"
xref: MassMono: "960.354663"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:155"
xref: GNOme: "GNO:G84825UQ"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00524
name: Hex1HexNAc2dHex2 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [RESID:AA0151#var, Unimod:156]
synonym: "Hex(1)HexNAc(2)dHex(2)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc2dHex2" RELATED Unimod-description []
xref: DiffAvg: "860.81"
xref: DiffFormula: "C 34 H 56 N 2 O 23"
xref: DiffMono: "860.327386"
xref: Formula: "C 38 H 62 N 4 O 25"
xref: MassAvg: "974.92"
xref: MassMono: "974.370313"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:156"
xref: GNOme: "GNO:G05460KC"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00525
name: Hex2HexNAc2Pent1 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [RESID:AA0151#var, Unimod:157]
synonym: "Hex(2)HexNAc(2)Pent(1)" RELATED PSI-MS-label []
synonym: "Hex2HexNAc2Pent1" RELATED Unimod-description []
xref: DiffAvg: "862.79"
xref: DiffFormula: "C 33 H 54 N 2 O 24"
xref: DiffMono: "862.306651"
xref: Formula: "C 37 H 60 N 4 O 26"
xref: MassAvg: "976.89"
xref: MassMono: "976.349578"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:157"
xref: GNOme: "GNO:G18999EB"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00526
name: Hex2HexNAc2dHex1 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [RESID:AA0151#var, Unimod:158]
synonym: "Hex(2)HexNAc(2)dHex(1)" RELATED PSI-MS-label []
synonym: "Hex2HexNAc2dHex1" RELATED Unimod-description []
xref: DiffAvg: "876.81"
xref: DiffFormula: "C 34 H 56 N 2 O 24"
xref: DiffMono: "876.322301"
xref: Formula: "C 38 H 62 N 4 O 26"
xref: MassAvg: "990.92"
xref: MassMono: "990.365228"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:158"
xref: GNOme: "GNO:G93579XB"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00527
name: Hex3HexNAc2 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [DeltaMass:0, RESID:AA0151#var, Unimod:159]
comment: From DeltaMass: Average Mass: 893
synonym: "(Hex)3-HexNAc-HexNAc" EXACT DeltaMass-label []
synonym: "Hex(3)HexNAc(2)" RELATED PSI-MS-label []
synonym: "Hex3HexNAc2" RELATED Unimod-description []
xref: DiffAvg: "892.81"
xref: DiffFormula: "C 34 H 56 N 2 O 25"
xref: DiffMono: "892.317215"
xref: Formula: "C 38 H 62 N 4 O 27"
xref: MassAvg: "1006.92"
xref: MassMono: "1006.360143"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:159"
xref: GNOme: "GNO:G28681TP"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00528
name: Hex1HexNAc1NeuAc2 glycosylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [Unimod:160]
synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc1NeuAc2" RELATED Unimod-description []
xref: DiffAvg: "947.85"
xref: DiffFormula: "C 36 H 57 N 3 O 26"
xref: DiffMono: "947.323029"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:160"
xref: GNOme: "GNO:G23729WG"
is_a: MOD:00725 ! complex glycosylation

[Term]
id: MOD:00529
name: Hex3HexNAc2P1 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [RESID:AA0151#var, Unimod:161]
synonym: "Hex(3)HexNAc(2)P(1)" RELATED PSI-MS-label []
synonym: "Hex3HexNAc2P1" RELATED Unimod-description []
xref: DiffAvg: "972.79"
xref: DiffFormula: "C 34 H 57 N 2 O 28 P 1"
xref: DiffMono: "972.283546"
xref: Formula: "C 38 H 63 N 4 O 30 P 1"
xref: MassAvg: "1086.89"
xref: MassMono: "1086.326473"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:161"
xref: GNOme: "GNO:G88520YF"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00530
name: L-selenomethionine
def: "A protein modification that effectively converts an L-methionine residue to L-selenomethionine." [OMSSA:113, PubMed:12148805, Unimod:162#M]
synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label []
synonym: "Se(S)Met" EXACT PSI-MOD-label []
synonym: "Selenium replaces sulphur" RELATED Unimod-description []
synonym: "semetm" EXACT OMSSA-label []
xref: DiffAvg: "46.91"
xref: DiffFormula: "C 0 H 0 N 0 S -1 Se 1"
xref: DiffMono: "47.944450"
xref: Formula: "C 5 H 9 N 1 O 1 Se 1"
xref: MassAvg: "178.10"
xref: MassMono: "178.984935"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:162"
is_a: MOD:00007 ! selenium substitution for sulfur
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:00531
name: (18)O labeled deglycosylated asparagine
def: "A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O as the result of having been deglycosylated in (18)O water." [PubMed:14435542, Unimod:170]
subset: PSI-MOD-slim
synonym: "Delta:H(1)O(-1)18O(1)" RELATED PSI-MS-label []
synonym: "glycosylated asparagine 18O labeling" RELATED Unimod-description []
xref: DiffAvg: "2.99"
xref: DiffFormula: "H -1 N -1 (18)O 1"
xref: DiffMono: "2.988262"
xref: Formula: "C 4 H 5 N 1 (16)O 2 (18)O 1"
xref: MassAvg: "117.03"
xref: MassMono: "117.031189"
xref: Origin: "N"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:170"
is_a: MOD:01293 ! 1x(18)O labeled deamidated L-asparagine

[Term]
id: MOD:00532
name: Shimadzu 13CNBS
def: "modification from Unimod Chemical derivative" [PubMed:12845591, Unimod:171]
synonym: "NBS:13C(6)" RELATED Unimod-interim []
synonym: "Shimadzu NBS-13C" RELATED Unimod-description []
xref: DiffAvg: "159.01"
xref: DiffFormula: "(13)C 6 H 3 N 1 O 2 S 1"
xref: DiffMono: "159.008578"
xref: Formula: "(12)C 11 (13)C 6 H 13 N 3 O 3 S 1"
xref: MassAvg: "345.09"
xref: MassMono: "345.087891"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:171"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00533
name: Shimadzu 12CNBS
def: "modification from Unimod Chemical derivative" [PubMed:12845591, Unimod:172]
synonym: "NBS" RELATED Unimod-interim []
synonym: "Shimadzu NBS-12C" RELATED Unimod-description []
xref: DiffAvg: "152.99"
xref: DiffFormula: "(12)C 6 H 3 N 1 O 2 S 1"
xref: DiffMono: "152.988449"
xref: Formula: "(12)C 17 H 13 N 3 O 3 S 1"
xref: MassAvg: "339.07"
xref: MassMono: "339.067762"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:172"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00534
name: Michael addition of BHT quinone methide to cysteine and lysine
def: "modification from Unimod Post-translational" [PubMed:9448752, Unimod:176]
comment: Butylated Hydroxytoluene adduct.
synonym: "BHT" RELATED PSI-MS-label []
synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED Unimod-description []
xref: DiffAvg: "218.34"
xref: DiffFormula: "C 15 H 22 O 1"
xref: DiffMono: "218.167065"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:176"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00535
name: phosphorylation to amine thiol
def: "modification from Unimod Chemical derivative" [PubMed:12216740, Unimod:178]
comment: DAET = 2-(dimethylamino)ethanethiol. The phosphorylation to amine is the beta elimination of phosphate and Michael addition of 2-(dimethylamino)ethanethiol to the site.
synonym: "DAET" RELATED PSI-MS-label []
synonym: "phosphorylation to amine thiol" RELATED Unimod-description []
xref: DiffAvg: "87.18"
xref: DiffFormula: "C 4 H 9 N 1 O -1 S 1"
xref: DiffMono: "87.050656"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:178"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00536
name: L-serine to L-alanine replacement
def: "OBSOLETE because Unimod 179 merged with Unimod 447 remap to ??? a protein modification that replaces an L-serine residue with an L-alanine residue" [Unimod:179]
synonym: "Ser_Ala" EXACT PSI-MOD-label []
xref: DiffAvg: "-16.00"
xref: DiffFormula: "O -1"
xref: DiffMono: "-15.994915"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:179"
is_obsolete: true

[Term]
id: MOD:00537
name: L-alanine residue (Thr)
def: "A protein modification that effectively converts an L-threonine residue to L-alanine." [Unimod:659]
comment: This could represent either an engineered replacement or a chemical modification.
synonym: "Thr(Ala)" EXACT PSI-MOD-label []
synonym: "Thr->Ala" RELATED Unimod-interim []
synonym: "Thr->Ala substitution" RELATED Unimod-description []
xref: DiffAvg: "-30.03"
xref: DiffFormula: "C -1 H -2 O -1"
xref: DiffMono: "-30.010565"
xref: Formula: "C 3 H 5 N 1 O 1"
xref: MassAvg: "71.08"
xref: MassMono: "71.037114"
xref: Origin: "T"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:659"
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:00538
name: protein modification categorized by isobaric sets
def: "Modified amino acid residues groups into isobaric sets at particular mass resolution cut-offs." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00000 ! protein modification

[Term]
id: MOD:00539
name: threonine reduced to aminobutynate
def: "OBSOLETE because Unimod 179 merged wth Unimod 447 remap to ??? modification from Unimod O-linked glycosylation" [Unimod:182]
xref: DiffAvg: "-17.01"
xref: DiffFormula: "H -1 O -1"
xref: DiffMono: "-17.002740"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:182"
is_obsolete: true

[Term]
id: MOD:00540
name: 9x(13)C labeled residue
def: "A protein modification that effectively converts a residue containing common isotopes to a 9x(13)C labeled residue." [PubMed:12716131, Unimod:184]
synonym: "13C(9) Silac label" RELATED Unimod-description []
synonym: "Label:13C(9)" RELATED PSI-MS-label []
xref: DiffAvg: "9.03"
xref: DiffFormula: "(12)C -9 (13)C 9"
xref: DiffMono: "9.030194"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:184"
is_a: MOD:00842 ! (13)C labeled residue

[Term]
id: MOD:00541
name: 9x(13)C labeled L-phosphotyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-phosphotyrosine." [PubMed:12716131, Unimod:185]
synonym: "C13 label (Phosphotyrosine)" RELATED Unimod-description []
synonym: "Label:13C(9)+Phospho" RELATED PSI-MS-label []
xref: DiffAvg: "89.00"
xref: DiffFormula: "(12)C -9 (13)C 9 H 1 O 3 P 1"
xref: DiffMono: "88.996524"
xref: Formula: "(13)C 9 H 10 N 1 O 5 P 1"
xref: MassAvg: "252.06"
xref: MassMono: "252.059853"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:185"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:00842 ! (13)C labeled residue
relationship: derives_from MOD:00540 ! 9x(13)C labeled residue
relationship: derives_from MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: MOD:00542
name: hydroxyphenylglyoxal arginine
def: "modification from Unimod Chemical derivative" [PubMed:11698400, PubMed:11914093, Unimod:186]
synonym: "HPG" RELATED PSI-MS-label []
synonym: "Hydroxyphenylglyoxal arginine" RELATED Unimod-description []
xref: DiffAvg: "132.12"
xref: DiffFormula: "C 8 H 4 O 2"
xref: DiffMono: "132.021129"
xref: Formula: "C 14 H 16 N 4 O 3"
xref: MassAvg: "288.31"
xref: MassMono: "288.122240"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:186"
is_a: MOD:00902 ! modified L-arginine residue
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00543
name: bis(hydroxyphenylglyoxal) arginine
def: "modification from Unimod Chemical derivative" [PubMed:11698400, Unimod:187]
comment: OH-PGO and PGO react with arginine at a stoichiometry of 2:1 [Unimod].
synonym: "2HPG" RELATED PSI-MS-label []
synonym: "bis(hydroxphenylglyoxal) arginine" RELATED Unimod-description []
xref: DiffAvg: "282.25"
xref: DiffFormula: "C 16 H 10 O 5"
xref: DiffMono: "282.052823"
xref: Formula: "C 22 H 22 N 4 O 6"
xref: MassAvg: "438.44"
xref: MassMono: "438.153934"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:187"
is_a: MOD:00902 ! modified L-arginine residue
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00544
name: 6x(13)C labeled residue
def: "A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C labeled residue." [PubMed:12716131, Unimod:188]
subset: PSI-MOD-slim
synonym: "13C(6) Silac label" RELATED Unimod-description []
synonym: "Label:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "6.02"
xref: DiffFormula: "(12)C -6 (13)C 6"
xref: DiffMono: "6.020129"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:188"
is_a: MOD:00842 ! (13)C labeled residue

[Term]
id: MOD:00545
name: deuterated dimethyl labeling (D)
def: "OBSOLETE because redundant with MOD:00927. Remap to MOD:00927." [PubMed:14670044]
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Remap: "MOD:00927"
is_obsolete: true

[Term]
id: MOD:00546
name: (18)O label at both C-terminal oxygens
def: "A protein modification that effectively substitutes two (18)O atom for the two (16)O atoms of an alpha-carboxyl (1-carboxyl) group." [OMSSA:88, PubMed:11467524, Unimod:193]
subset: PSI-MOD-slim
synonym: "ctermpepdio18" EXACT OMSSA-label []
synonym: "Label:18O(2)" RELATED PSI-MS-label []
synonym: "O18 label at both C-terminal oxygens" RELATED Unimod-description []
xref: DiffAvg: "4.01"
xref: DiffFormula: "(16)O -2 (18)O 2"
xref: DiffMono: "4.008493"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:193"
is_a: MOD:00847 ! (18)O disubstituted residue

[Term]
id: MOD:00547
name: 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate
def: "modification from Unimod Chemical derivative used for amino acid analysis" [PubMed:14997490, Unimod:194]
synonym: "6-aminoquinolyl-N-hydroxysuccinimidyl carbamate" RELATED Unimod-description []
synonym: "AccQTag" RELATED PSI-MS-label []
xref: DiffAvg: "170.17"
xref: DiffFormula: "C 10 H 6 N 2 O 1"
xref: DiffMono: "170.048013"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:194"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00548
name: APTA
def: "modification from Unimod Chemical derivative" [PubMed:15283597, Unimod:195]
comment: Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride [JSG].
synonym: "APTA-d0" RELATED Unimod-description []
synonym: "QAT" RELATED PSI-MS-label []
xref: DiffAvg: "171.26"
xref: DiffFormula: "C 9 H 19 N 2 O 1"
xref: DiffMono: "171.149738"
xref: Formula: "C 12 H 24 N 3 O 2 S 1"
xref: MassAvg: "274.40"
xref: MassMono: "274.158923"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:195"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00549
name: APTA d3
def: "modification from Unimod Isotopic label" [PubMed:15283597, Unimod:196]
comment: Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride (difference formula correct) [JSG].
synonym: "(3-acrylamidopropyl)trimethylammonium" RELATED Unimod-description []
synonym: "APTA d3" RELATED Unimod-description []
synonym: "QAT:2H(3)" RELATED PSI-MS-label []
xref: DiffAvg: "174.17"
xref: DiffFormula: "C 9 (1)H 16 (2)H 3 N 2 O 1"
xref: DiffMono: "174.168568"
xref: Formula: "C 12 (1)H 21 (2)H 3 N 3 O 2 S 1"
xref: MassAvg: "277.18"
xref: MassMono: "277.177753"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:196"
is_a: MOD:01431 ! (2)H deuterium tagged reagent

[Term]
id: MOD:00550
name: EAPTA d0
def: "modification from Unimod Chemical derivative" [Unimod:197]
synonym: "EAPTA d0" RELATED Unimod-description []
synonym: "EQAT" RELATED PSI-MS-label []
xref: DiffAvg: "184.28"
xref: DiffFormula: "C 10 H 20 N 2 O 1"
xref: DiffMono: "184.157563"
xref: Formula: "C 13 H 25 N 3 O 2 S 1"
xref: MassAvg: "287.42"
xref: MassMono: "287.166748"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:197"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00551
name: EAPTA d5
def: "modification from Unimod Isotopic label" [Unimod:198]
synonym: "EAPTA d5" RELATED Unimod-description []
synonym: "EQAT:2H(5)" RELATED PSI-MS-label []
xref: DiffAvg: "189.19"
xref: DiffFormula: "C 10 (1)H 15 (2)H 5 N 2 O 1"
xref: DiffMono: "189.188947"
xref: Formula: "C 13 (1)H 20 (2)H 5 N 3 O 2 S 1"
xref: MassAvg: "292.20"
xref: MassMono: "292.198132"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:198"
is_a: MOD:01431 ! (2)H deuterium tagged reagent

[Term]
id: MOD:00552
name: 4x(2)H labeled dimethylated residue
def: "A protein modification that effectively converts a residue containing common isotopes to a 4x(2)H labeled dimethylated residue." [PubMed:14670044, Unimod:199]
comment: Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction.
subset: PSI-MOD-slim
synonym: "DiMethyl-CHD2" RELATED Unimod-description []
synonym: "Dimethyl:2H(4)" RELATED PSI-MS-label []
xref: DiffAvg: "32.06"
xref: DiffFormula: "C 2 (2)H 4"
xref: DiffMono: "32.056407"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:199"
is_a: MOD:00839 ! (2)H deuterium labeled residue

[Term]
id: MOD:00553
name: 1,2-ethanedithiol modified residue
def: "A protein modification that effectively substitutes a (2-sulfanylethyl)sulfanyl (or thioethylthiol) group for a hydroxy group." [DeltaMass:0, PubMed:11507762, Unimod:200]
comment: From DeltaMass: Average Mass: 93; supposed to be derivatization of serine and threonine.
synonym: "1,2-ethanedithiol (EDT)" EXACT DeltaMass-label []
synonym: "EDT" RELATED Unimod-description []
synonym: "Ethanedithiol" RELATED PSI-MS-label []
xref: DiffAvg: "76.18"
xref: DiffFormula: "C 2 H 4 O -1 S 2"
xref: DiffMono: "75.980528"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:200"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00554
name: APTA-d0 with no neutral loss
def: "OBSOLETE because Unimod entry 202 was merged with entry 195, remap to MOD:00548. modification from Unimod Chemical derivative" [Unimod:202]
xref: DiffAvg: "170.26"
xref: DiffFormula: "C 9 H 18 N 2 O 1"
xref: DiffMono: "170.141913"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00548"
xref: Unimod: "Unimod:202"
is_obsolete: true

[Term]
id: MOD:00555
name: APTA-d0 with quaternary amine loss
def: "OBSOLETE because Unimod entry 202 was merged with entry 195, remap to MOD:00548. modification from Unimod Chemical derivative" [Unimod:203]
xref: DiffAvg: "170.26"
xref: DiffFormula: "C 9 H 18 N 2 O 1"
xref: DiffMono: "170.141913"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00548"
xref: Unimod: "Unimod:203"
is_obsolete: true

[Term]
id: MOD:00556
name: acrolein addition +94
def: "OBSOLETE because this modification not supported by any literature that I can find[PMT]" [Unimod:205]
synonym: "Acrolein addition +94" RELATED Unimod-description []
synonym: "Delta:H(6)C(6)O(1)" RELATED PSI-MS-label []
xref: DiffAvg: "94.11"
xref: DiffFormula: "C 6 H 6 O 1"
xref: DiffMono: "94.041865"
xref: Formula: "C 12 H 18 N 2 O 2"
xref: MassAvg: "222.29"
xref: MassMono: "222.136828"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:205"
is_obsolete: true

[Term]
id: MOD:00557
name: acrolein addition +56
def: "OBSOLETE because this modification not supported by the papers listed or any other that I can find[PMT]" [PubMed:10825247, PubMed:15541752, Unimod:206]
synonym: "Acrolein addition +56" RELATED Unimod-description []
synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label []
xref: DiffAvg: "56.06"
xref: DiffFormula: "C 3 H 4 O 1"
xref: DiffMono: "56.026215"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:206"
is_obsolete: true

[Term]
id: MOD:00558
name: acrolein addition +38
def: "OBSOLETE because this modification not supported by any literature that I can find[PMT]" [Unimod:207]
synonym: "Acrolein addition +38" RELATED Unimod-description []
synonym: "Delta:H(2)C(3)" RELATED PSI-MS-label []
xref: DiffAvg: "38.05"
xref: DiffFormula: "C 3 H 2"
xref: DiffMono: "38.015650"
xref: Formula: "C 9 H 14 N 2 O 1"
xref: MassAvg: "166.22"
xref: MassMono: "166.110613"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:207"
is_obsolete: true

[Term]
id: MOD:00559
name: acrolein addition +76
def: "OBSOLETE because this modification not supported by any literature that I can find[PMT]" [Unimod:208]
synonym: "Acrolein addition +76" RELATED Unimod-description []
synonym: "Delta:H(4)C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "76.10"
xref: DiffFormula: "C 6 H 4"
xref: DiffMono: "76.031300"
xref: Formula: "C 12 H 16 N 2 O 1"
xref: MassAvg: "204.27"
xref: MassMono: "204.126263"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:208"
is_obsolete: true

[Term]
id: MOD:00560
name: acrolein addition +112
def: "OBSOLETE because this modification not supported by any literature that I can find[PMT]" [Unimod:209]
synonym: "Acrolein addition +112" RELATED Unimod-description []
synonym: "Delta:H(8)C(6)O(2)" RELATED PSI-MS-label []
xref: DiffAvg: "112.13"
xref: DiffFormula: "C 6 H 8 O 2"
xref: DiffMono: "112.052429"
xref: Formula: "C 12 H 20 N 2 O 3"
xref: MassAvg: "240.30"
xref: MassMono: "240.147393"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:209"
is_obsolete: true

[Term]
id: MOD:00561
name: N-ethyl iodoacetamide-
def: "modification from Unimod Isotopic label" [PubMed:12766232, Unimod:211]
synonym: "N-ethyl iodoacetamide-d0" RELATED Unimod-description []
synonym: "NEIAA" RELATED PSI-MS-label []
xref: DiffAvg: "85.11"
xref: DiffFormula: "C 4 H 7 N 1 O 1"
xref: DiffMono: "85.052764"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:211"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00562
name: N-ethyl iodoacetamide-d5
def: "modification from Unimod Isotopic label" [PubMed:12766232, Unimod:212]
synonym: "N-ethyl iodoacetamide-d5" RELATED Unimod-description []
synonym: "NEIAA:2H(5)" RELATED PSI-MS-label []
xref: DiffAvg: "90.08"
xref: DiffFormula: "C 4 (1)H 2 (2)H 5 N 1 O 1"
xref: DiffMono: "90.084148"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:212"
is_a: MOD:01431 ! (2)H deuterium tagged reagent

[Term]
id: MOD:00563
name: mono-N-acetylaminogalactosylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an N-acetylaminogalactose group through a glycosidic bond." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "GalNAcRes" EXACT PSI-MOD-label []
synonym: "HexNAc" RELATED PSI-MS-label []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00734 ! N-acetylaminogalactosylated
is_a: MOD:01673 ! N-acetylaminohexosylated residue

[Term]
id: MOD:00564
name: Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry
def: "Modification from Unimod Isotopic label. The Unimod term was extracted when it had not been approved. OBSOLETE because redundant to MOD:01505. Remap to MOD:01505, or one of the child terms MOD:01493 or MOD:01497." [Unimod:214, URL:http\://docs.appliedbiosystems.com/pebiodocs/04351918.pdf]
synonym: "iTRAQ4plex" RELATED Unimod-interim []
synonym: "Representative mass and accurate mass for 116 & 117" RELATED Unimod-description []
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:01505"
xref: Unimod: "Unimod:214"
is_obsolete: true

[Term]
id: MOD:00565
name: deglycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [Unimod:7#N]
comment: Conversion of glycosylated asparagine residues upon deglycosylation with PGNase F in H2O. CAUTION - the difference formula appears to be based on a partial structure [JSG].
synonym: "Deamidated" RELATED Unimod-interim []
synonym: "Deamidation" RELATED Unimod-description []
xref: DiffAvg: "0.98"
xref: DiffFormula: "H -1 N -1 O 1"
xref: DiffMono: "0.984016"
xref: Formula: "C 4 H 5 N 1 O 3"
xref: MassAvg: "115.09"
xref: MassMono: "115.026943"
xref: Origin: "N"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:7"
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:00566
name: label cysteine with IGBP reagent
def: "modification from Unimod Chemical derivative" [Unimod:243]
comment: "IDBEST tag for quantitation, http://www.targetdiscovery.com/index.php?topic=prod.idbe"
synonym: "IGBP" RELATED PSI-MS-label []
synonym: "Light IDBEST tag for quantitation" RELATED Unimod-description []
xref: DiffAvg: "297.15"
xref: DiffFormula: "Br 1 C 12 H 13 N 2 O 2"
xref: DiffMono: "296.016040"
xref: Formula: "Br 1 C 15 H 18 N 3 O 3 S 1"
xref: MassAvg: "400.29"
xref: MassMono: "399.025225"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:243"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00567
name: histidine oxidation to asparagine
def: "OBSOLETE because Unimod entry 244 is redundant with Unimod 348. Remap to MOD:00775." [ChEBI:29956, PubMed:15736973, PubMed:5681232, PubMed:6692818, PubMed:9789001, RESID:AA0003, Unimod:244]
xref: DiffAvg: "-23.04"
xref: DiffFormula: "C -2 H -1 N -1 O 1"
xref: DiffMono: "-23.015984"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:244"
is_obsolete: true

[Term]
id: MOD:00568
name: histidine oxidation to aspartic acid
def: "OBSOLETE because Unimod entry 245 is redundant with Unimod 349. Remap to MOD:00776" [PubMed:1097438, PubMed:339692, PubMed:4399050, PubMed:5764436, PubMed:6692818, PubMed:8089117, PubMed:9521123, PubMed:9582379, Unimod:245]
xref: DiffAvg: "-22.05"
xref: DiffFormula: "C -2 H -2 N -2 O 2"
xref: DiffMono: "-22.031969"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00776"
xref: Unimod: "Unimod:245"
is_obsolete: true

[Term]
id: MOD:00569
name: residues isobaric at a resolution below 0.000001 Da
def: "Natural or modified residues that are isobaric at a resolution below 0.000001 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da

[Term]
id: MOD:00570
name: residues isobaric at 71.037114 Da
def: "Natural or modified residues with a mass of 71.037114 Da." [PubMed:18688235]
is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da
is_a: MOD:00769 ! residues isobaric at 71.0-71.1 Da

[Term]
id: MOD:00571
name: 2-pyrrolidone-5-carboxylic acid (Pro)
def: "A modification that effectively oxygenates C5 of an L-proline residue to form a 2-pyrrolidone-5-carboxylic acid, pyroglutamic acid." [OMSSA:111, PubMed:9252331, Unimod:359]
comment: The review article PubMed:9252331 does not provide an original citation for this modification [JSG].
synonym: "Pro->pyro-Glu" RELATED PSI-MS-label []
synonym: "PyrGlu(Pro)" EXACT PSI-MOD-label []
synonym: "Pyroglutamic" RELATED Unimod-interim []
synonym: "pyroglutamicp" EXACT OMSSA-label []
xref: DiffAvg: "13.98"
xref: DiffFormula: "H -2 O 1"
xref: DiffMono: "13.979265"
xref: Formula: "C 5 H 6 N 1 O 2"
xref: MassAvg: "112.11"
xref: MassMono: "112.039853"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:359"
is_a: MOD:00679 ! carbon oxygenated residue
is_a: MOD:00915 ! modified L-proline residue
is_a: MOD:01048 ! 2-pyrrolidone-5-carboxylic acid

[Term]
id: MOD:00572
name: oxidized arginine biotinylated with biotin hydrazide
def: "modification from Unimod Chemical derivative" [PubMed:15174056, PubMed:15828771, Unimod:343]
synonym: "Argbiotinhydrazide" RELATED Unimod-interim []
synonym: "oxidized Arginine biotinylated with biotin hydrazide" RELATED Unimod-description []
xref: DiffAvg: "199.27"
xref: DiffFormula: "C 9 H 13 N 1 O 2 S 1"
xref: DiffMono: "199.066700"
xref: Formula: "C 15 H 25 N 5 O 3 S 1"
xref: MassAvg: "355.46"
xref: MassMono: "355.167811"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:343"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00573
name: oxidized lysine biotinylated with biotin hydrazide
def: "modification from Unimod Chemical derivative" [PubMed:15174056, Unimod:353]
comment: "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB"
synonym: "Lysbiotinhydrazide" RELATED Unimod-interim []
synonym: "oxidized Lysine biotinylated with biotin hydrazide" RELATED Unimod-description []
xref: DiffAvg: "241.31"
xref: DiffFormula: "C 10 H 15 N 3 O 2 S 1"
xref: DiffMono: "241.088498"
xref: Formula: "C 16 H 27 N 5 O 3 S 1"
xref: MassAvg: "369.48"
xref: MassMono: "369.183461"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:353"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00574
name: oxidized proline biotinylated with biotin hydrazide
def: "modification from Unimod Chemical derivative" [PubMed:15174056, Unimod:357]
comment: "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB"
synonym: "oxidized proline biotinylated with biotin hydrazide" RELATED Unimod-description []
synonym: "probiotinhydrazide" RELATED Unimod-interim []
xref: DiffAvg: "258.34"
xref: DiffFormula: "C 10 H 18 N 4 O 2 S 1"
xref: DiffMono: "258.115047"
xref: Formula: "C 15 H 25 N 5 O 3 S 1"
xref: MassAvg: "355.46"
xref: MassMono: "355.167811"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:357"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:00575
name: oxidized threonine biotinylated with biotin hydrazide
def: "modification from Unimod Chemical derivative" [PubMed:15174056, Unimod:361]
comment: "http://www.piercenet.com/Proteomics/browse.cfm?fldID=84EBE112-F871-4CA5-807F-47327153CFCB"
synonym: "oxidized Threonine biotinylated with biotin hydrazide" RELATED Unimod-description []
synonym: "Thrbiotinhydrazide" RELATED Unimod-interim []
xref: DiffAvg: "240.32"
xref: DiffFormula: "C 10 H 16 N 4 O 1 S 1"
xref: DiffMono: "240.104482"
xref: Formula: "C 14 H 23 N 5 O 3 S 1"
xref: MassAvg: "341.43"
xref: MassMono: "341.152161"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:361"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:00576
name: crotonylated residue
def: "modification from Unimod Other" [PubMed:11283024, PubMed:25907603, Unimod:253]
synonym: "Crotonaldehyde" RELATED PSI-MS-label []
synonym: "Crotonaldehyde" RELATED Unimod-description []
xref: DiffAvg: "70.09"
xref: DiffFormula: "C 4 H 6 O 1"
xref: DiffMono: "70.041865"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:253"
is_a: MOD:00649 ! acylated residue

[Term]
id: MOD:00577
name: acetaldehyde crosslinked penta-L-lysine
def: "modification occurs as a Schiff base in the presence of pentalysine" [PubMed:7744761, Unimod:254]
synonym: "Acetaldehyde +26" RELATED Unimod-description []
synonym: "Delta:H(2)C(2)" RELATED PSI-MS-label []
xref: DiffAvg: "26.04"
xref: DiffFormula: "C 2 H 2"
xref: DiffMono: "26.015650"
xref: Formula: "C 8 H 14 N 2 O 1"
xref: MassAvg: "666.91"
xref: MassMono: "666.490465"
xref: Origin: "K, K, K, K, K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:254"
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:00692 ! uncategorized crosslinked residues

[Term]
id: MOD:00578
name: acetaldehyde +28
def: "OBSOLETE because this modification not supported by any literature that I can find [PMT]" [Unimod:255]
synonym: "Acetaldehyde +28" RELATED Unimod-description []
synonym: "Delta:H(4)C(2)" RELATED PSI-MS-label []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4"
xref: DiffMono: "28.031300"
xref: Formula: "C "
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:255"
is_obsolete: true

[Term]
id: MOD:00579
name: propionaldehyde +40
def: "OBSOLETE because not supported by the linked literature [PMT]. modification from Unimod Other" [Unimod:256]
synonym: "Delta:H(4)C(3)" RELATED PSI-MS-label []
synonym: "Propionaldehyde +40" RELATED Unimod-description []
xref: DiffAvg: "40.06"
xref: DiffFormula: "C 3 H 4"
xref: DiffMono: "40.031300"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:256"
is_obsolete: true

[Term]
id: MOD:00580
name: propionaldehyde +42
def: "OBSOLETE because entry removed from Unimod. Remap potentially to MOD:00579 propionaldehyde +40" [Unimod:257]
xref: DiffAvg: "42.08"
xref: DiffFormula: "C 3 H 6"
xref: DiffMono: "42.046950"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00579"
xref: Unimod: "Unimod:257"
is_obsolete: true

[Term]
id: MOD:00581
name: (18)O monosubstituted residue
def: "A protein modification that effectively substitutes one (18)O atom for one (16)O atom." [OMSSA:87, PubMed:11467524, Unimod:258]
subset: PSI-MOD-slim
synonym: "ctermpepo18" EXACT OMSSA-label []
synonym: "Label:18O(1)" RELATED PSI-MS-label []
synonym: "O18 Labeling" RELATED Unimod-description []
xref: DiffAvg: "2.00"
xref: DiffFormula: "(16)O -1 (18)O 1"
xref: DiffMono: "2.004246"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:258"
is_a: MOD:00845 ! (18)O substituted residue

[Term]
id: MOD:00582
name: 6x(13)C,2x(15)N labeled L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 6x(13)C,2x(15)N labeled L-lysine." [OMSSA:181, PubMed:12716131, Unimod:259]
synonym: "13C(6) 15N(2) Silac label" RELATED Unimod-description []
synonym: "Label:13C(6)15N(2)" RELATED PSI-MS-label []
synonym: "lys-13C615N2" EXACT OMSSA-label []
xref: DiffAvg: "8.01"
xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -2 (15)N 2"
xref: DiffMono: "8.014199"
xref: Formula: "(13)C 6 H 12 (15)N 2 O 1"
xref: MassAvg: "136.11"
xref: MassMono: "136.109162"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:259"
is_a: MOD:00842 ! (13)C labeled residue
is_a: MOD:00843 ! (15)N labeled residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00583
name: thiophosphorylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a thiophosphono group (H2PO2S, 'thiophosphate')." [PubMed:12110917, Unimod:260]
synonym: "Thiophospho" RELATED PSI-MS-label []
synonym: "Thiophosphorylation" RELATED Unimod-description []
xref: DiffAvg: "96.04"
xref: DiffFormula: "H 1 O 2 P 1 S 1"
xref: DiffMono: "95.943487"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:260"
is_a: MOD:00860 ! sulfur containing modified residue
is_a: MOD:00861 ! phosphorus containing modified residue

[Term]
id: MOD:00584
name: 4-sulfophenyl isothiocyanate derivatized residue
def: "A protein modification produced by formation of an adduct with 4-sulfophenyl isothiocyanate." [PubMed:14689565, PubMed:14745769, PubMed:16526082, Unimod:261]
synonym: "4-sulfophenyl isothiocyanate" RELATED Unimod-description []
synonym: "SPITC" RELATED PSI-MS-label []
xref: DiffAvg: "215.24"
xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2"
xref: DiffMono: "214.971085"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:261"
is_a: MOD:00841 ! isothiocyanate reagent derivatized residue

[Term]
id: MOD:00585
name: deuterium trisubstituted residue
def: "A protein modification that effectively substitutes three (2)H deuterium atoms for three (1)H protium atoms." [Unimod:262]
synonym: "D(H)3Res" EXACT PSI-MOD-label []
synonym: "Label:2H(3)" RELATED PSI-MS-label []
synonym: "Trideuteration" RELATED Unimod-description []
xref: DiffAvg: "3.02"
xref: DiffFormula: "(1)H -3 (2)H 3"
xref: DiffMono: "3.018830"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:262"
is_a: MOD:00786 ! deuterium substituted residue

[Term]
id: MOD:00586
name: pyridyl thiol modified residue
def: "modification from Unimod Chemical derivative" [Unimod:264]
synonym: "PET" RELATED PSI-MS-label []
synonym: "phosphorylation to pyridyl thiol" RELATED Unimod-description []
xref: DiffAvg: "121.20"
xref: DiffFormula: "C 7 H 7 N 1 O -1 S 1"
xref: DiffMono: "121.035006"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:264"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00587
name: 6x(13)C,4x(15)N labeled L-arginine
def: "A protein modification that effectively converts an L-arginine residue to 6x(13)C, 4x(15)N labeled L-arginine." [OMSSA:137, PubMed:12716131, Unimod:267]
subset: PSI-MOD-slim
synonym: "13C(6) 15N(4) Silac label" RELATED Unimod-description []
synonym: "arg-13c6-15n4" EXACT OMSSA-label []
synonym: "Label:13C(6)15N(4)" RELATED PSI-MS-label []
xref: DiffAvg: "10.01"
xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -4 (15)N 4"
xref: DiffMono: "10.008269"
xref: Formula: "(13)C 6 H 12 (15)N 4 O 1"
xref: MassAvg: "166.11"
xref: MassMono: "166.109380"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:267"
is_a: MOD:00842 ! (13)C labeled residue
is_a: MOD:00843 ! (15)N labeled residue
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00588
name: 5x(13)C,1x(15)N labeled L-valine
def: "A protein modification that effectively converts an L-valine residue to 5x(13)C,1x(15)N labeled L-valine." [PubMed:12771378, Unimod:268#V]
synonym: "13C(5) 15N(1) Silac label" RELATED Unimod-description []
synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label []
xref: DiffAvg: "6.01"
xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1"
xref: DiffMono: "6.013809"
xref: Formula: "(13)C 5 H 9 (15)N 1 O 1"
xref: MassAvg: "105.08"
xref: MassMono: "105.082223"
xref: Origin: "V"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:268"
is_a: MOD:00920 ! modified L-valine residue
is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue

[Term]
id: MOD:00589
name: 9x(13)C,1x(15)N labeled L-phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to (13)C,(15)N labeled L-phenylalanine." [PubMed:12771378, Unimod:269]
synonym: "13C(9) 15N(1) Silac label" RELATED Unimod-description []
synonym: "Label:13C(9)15N(1)" RELATED PSI-MS-label []
xref: DiffAvg: "10.03"
xref: DiffFormula: "(12)C -9 (13)C 9 (14)N -1 (15)N 1"
xref: DiffMono: "10.027228"
xref: Formula: "(13)C 9 H 9 (15)N 1 O 1"
xref: MassAvg: "157.10"
xref: MassMono: "157.095642"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:269"
is_a: MOD:00842 ! (13)C labeled residue
is_a: MOD:00843 ! (15)N labeled residue
is_a: MOD:00914 ! modified L-phenylalanine residue

[Term]
id: MOD:00590
name: nucleophilic addtion to cytopiloyne
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative" [PubMed:15549660, Unimod:270]
synonym: "Cytopiloyne" RELATED PSI-MS-label []
synonym: "nucleophilic addtion to cytopiloyne" RELATED Unimod-description []
xref: DiffAvg: "362.38"
xref: DiffFormula: "C 19 H 22 O 7"
xref: DiffMono: "362.136553"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:270"
is_obsolete: true

[Term]
id: MOD:00591
name: nucleophilic addition to cytopiloyne+H2O
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative" [PubMed:15549660, Unimod:271]
synonym: "Cytopiloyne+water" RELATED PSI-MS-label []
synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED Unimod-description []
xref: DiffAvg: "380.39"
xref: DiffFormula: "C 19 H 24 O 8"
xref: DiffMono: "380.147118"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:271"
is_obsolete: true

[Term]
id: MOD:00592
name: sulfonation of N-terminal
def: "modification from Unimod Chemical derivative" [PubMed:12705581, PubMed:15732931, PubMed:16046801, Unimod:272]
synonym: "CAF" RELATED PSI-MS-label []
synonym: "sulfonation of N-terminus" RELATED Unimod-description []
xref: DiffAvg: "136.12"
xref: DiffFormula: "C 3 H 4 O 4 S 1"
xref: DiffMono: "135.983030"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:272"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00593
name: covalent modification of lysine by omega-maleimido alkanoyl N-hydroxysuccinimido esters
def: "OBSOLETE because removed from Unimod. modification from Unimod Chemical derivative" [Unimod:273]
comment: J. Prot. Chem. 2, 263-277, 1983
synonym: "covalent modification of lysine by cross-linking reagent" RELATED Unimod-description []
synonym: "Xlink:SSD" RELATED PSI-MS-label []
xref: DiffAvg: "253.25"
xref: DiffFormula: "C 12 H 15 N 1 O 5"
xref: DiffMono: "253.095023"
xref: Formula: "C 18 H 27 N 3 O 6"
xref: MassAvg: "381.43"
xref: MassMono: "381.189986"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:273"
is_obsolete: true

[Term]
id: MOD:00594
name: residues isobaric at 113.047678 Da
def: "Natural or modified resiues with a mass of 113.047678 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da
is_a: MOD:00624 ! residues isobaric at 113.0-113.1 Da

[Term]
id: MOD:00595
name: monomannosylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an manose group through a glycosidic bond" [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ManRes" EXACT PSI-MOD-label []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00727 ! mannosylated residue
is_a: MOD:00761 ! monohexosylated residue

[Term]
id: MOD:00596
name: 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue
def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS." [DeltaMass:235, PubMed:8597590, Unimod:276]
comment: From DeltaMass: Average Mass: 183 Average Mass Change:183 References:We have found that AEBSF modifies many proteins by covalent attachment, preferentially on Tyr, and to a lesser extent on Lys, His, and the amino-terminus. These modifications were identified by electrospray MS of the proteins (adds 183 Da per AEBS-group) and by peptide mapping and MS/MS. All the proteins we examined were modified after 24 hrs. at 4 C with 1 mM AEBSF in TRIS, pH 8.0. The reaction is 10-20x slower at pH 7; however AEBSF is quite stable in aqueous solution and the extent of to which the protein is modified continues to increase for several days. We have seen the addition of 10 or more AEBS-groups to proteins after prolonged storage. We found no equivalent modification from PMSF, probably because it degrades so quickly. We no longer use AEBSF, and urge caution to those who do. To address the problem, Boehringer Mannheim (now Roche Molecular Biochemicals) introduced Pefabloc PLUS which includes an additional component to compete for these side reactions. In our limited experience with Pefabloc PLUS, it reduces the +183 modifications, but does not always eliminate them. As a result, we prefer PMSF, despite its own set of drawbacks. We have never found PMSF-induced modification of proteins (except trypsin), probably due to its short half-life in aqeous solution.
synonym: "AEBS" RELATED PSI-MS-label []
synonym: "AEBSF" EXACT DeltaMass-label []
synonym: "Aminoethylbenzenesulfonylation" RELATED Unimod-description []
xref: DiffAvg: "183.23"
xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1"
xref: DiffMono: "183.035400"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:276"
is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue

[Term]
id: MOD:00597
name: methyl methanethiosulfonate
def: "OBSOLETE because Unimod entry 277 redundant with Unimod 39. Remap to MOD:00110." [Unimod:277]
xref: DiffAvg: "46.09"
xref: DiffFormula: "C 1 H 2 S 1"
xref: DiffMono: "45.987721"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00110"
xref: Unimod: "Unimod:277"
is_obsolete: true

[Term]
id: MOD:00598
name: S-(2-hydroxyethyl)cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(2-hydroxyethyl)cysteine" [PubMed:15351294, Unimod:278]
comment: This modification of cysteine is produced by the reagent iodoethanol with triethylphosphine [JSG].
subset: PSI-MOD-slim
synonym: "Ethanolation of Cys" RELATED Unimod-description []
synonym: "Ethanolyl" RELATED PSI-MS-label []
xref: DiffAvg: "44.05"
xref: DiffFormula: "C 2 H 4 O 1"
xref: DiffMono: "44.026215"
xref: Formula: "C 5 H 9 N 1 O 2 S 1"
xref: MassAvg: "147.19"
xref: MassMono: "147.035400"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:278"
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00599
name: monomethylated residue
def: "A protein modification that effectively replaces one hydrogen atom with one methyl group." [PubMed:11875433, Unimod:34]
subset: PSI-MOD-slim
synonym: "Me1Res" EXACT PSI-MOD-label []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2"
xref: DiffMono: "14.015650"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
is_a: MOD:00427 ! methylated residue

[Term]
id: MOD:00600
name: L-glutamic acid 5-ethyl ester
def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-ethyl ester." [DeltaMass:0, PubMed:9629898, Unimod:280#E]
comment: From DeltaMass: Average Mass: 28 with no citation. The Unimod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation. For dimethylated residues, see MOD:00429 and its children [JSG].
synonym: "Ethyl" EXACT DeltaMass-label []
synonym: "Ethyl" RELATED PSI-MS-label []
synonym: "Ethylation" RELATED Unimod-description []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4"
xref: DiffMono: "28.031300"
xref: Formula: "C 7 H 11 N 1 O 3"
xref: MassAvg: "157.17"
xref: MassMono: "157.073893"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:280"
is_a: MOD:00906 ! modified L-glutamic acid residue
is_a: MOD:01339 ! ethylated residue

[Term]
id: MOD:00601
name: cyclized residue
def: "A protein modification that effectively produces an heterocyclic amino acid with a covalent bond between the side chain and either its alpha amino or 1-carboxyl group, possibly breaking the peptide chain." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "CycRes" EXACT PSI-MOD-label []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00602
name: N-methylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with an methyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "NMeRes" EXACT PSI-MOD-label []
is_a: MOD:00427 ! methylated residue

[Term]
id: MOD:00603
name: N-ethylation
def: "OBSOLETE because Unimod entry 283 is redundant with Unimod 280. Remap to MOD:00600" [Unimod:283]
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4"
xref: DiffMono: "28.031300"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Remap: "MOD:00600"
xref: Unimod: "Unimod:283"
is_obsolete: true

[Term]
id: MOD:00604
name: 2x(2)H monomethylated L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 2x(2)H labeled monomethylated L-lysine." [PubMed:15525938, Unimod:284]
synonym: "Deuterium Methylation of Lysine" RELATED Unimod-description []
synonym: "Methyl:2H(2)" RELATED PSI-MS-label []
xref: DiffAvg: "16.03"
xref: DiffFormula: "C 1 (2)H 2"
xref: DiffMono: "16.028204"
xref: Formula: "C 7 (1)H 12 (2)H 2 N 2 O 1"
xref: MassAvg: "144.12"
xref: MassMono: "144.123167"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:284"
is_a: MOD:00839 ! (2)H deuterium labeled residue
is_a: MOD:00912 ! modified L-lysine residue
relationship: derives_from MOD:00085 ! N6-methyl-L-lysine

[Term]
id: MOD:00605
name: Sulfanilic Acid (SA), light C12
def: "modification from Unimod Chemical derivative, C-Terminal/Glutamate/Aspartate sulfonation" [Unimod:285]
synonym: "Light Sulfanilic Acid (SA) C12" RELATED Unimod-description []
synonym: "SulfanilicAcid" RELATED PSI-MS-label []
xref: DiffAvg: "155.00"
xref: DiffFormula: "(12)C 6 H 5 N 1 O 2 S 1"
xref: DiffMono: "155.004099"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:285"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00606
name: Sulfanilic Acid (SA), heavy C13
def: "modification from Unimod Chemical derivative" [PubMed:9254591, Unimod:286]
synonym: "Heavy Sulfanilic Acid (SA) C13" RELATED Unimod-description []
synonym: "SulfanilicAcid:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "161.02"
xref: DiffFormula: "(13)C 6 H 5 N 1 O 2 S 1"
xref: DiffMono: "161.024228"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:286"
is_a: MOD:01428 ! (13)C isotope tagged reagent

[Term]
id: MOD:00607
name: dioxoindolealanine lactone
def: "modification from Unimod Chemical derivative" [PubMed:7949339, Unimod:288]
comment: Unimod name, formula, and terminal specification corrected. Formula corresponded to uncleaved intermediate [JSG].
synonym: "Trp->Oxolactone" RELATED PSI-MS-label []
synonym: "Tryptophan oxidation to oxolactone" RELATED Unimod-description []
xref: DiffAvg: "30.99"
xref: DiffFormula: "H -1 O 2"
xref: DiffMono: "30.982004"
xref: Formula: "C 11 H 9 N 2 O 3"
xref: MassAvg: "217.20"
xref: MassMono: "217.061317"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:288"
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:00608
name: biotin polyethyleneoxide amine
def: "modification from Unimod Chemical derivative" [Unimod:289]
synonym: "Biotin polyethyleneoxide amine" RELATED Unimod-description []
synonym: "Biotin-PEO-Amine" RELATED Unimod-interim []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:289"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00609
name: Pierce EZ-Link Biotin-HPDP modified L-cysteine
def: "modification from Unimod Chemical derivative" [Unimod:290]
synonym: "Biotin-HPDP" RELATED Unimod-interim []
synonym: "Pierce EZ-Link Biotin-HPDP" RELATED Unimod-description []
xref: DiffAvg: "428.61"
xref: DiffFormula: "C 19 H 32 N 4 O 3 S 2"
xref: DiffMono: "428.191583"
xref: Formula: "C 22 H 37 N 5 O 4 S 3"
xref: MassAvg: "531.75"
xref: MassMono: "531.200768"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:290"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00610
name: cysteinyl mercury
def: "modification from Unimod Chemical derivative" [PubMed:10695144, Unimod:291]
synonym: "Delta:Hg(1)" RELATED PSI-MS-label []
synonym: "Mercury Mercaptan" RELATED Unimod-description []
xref: DiffAvg: "200.59"
xref: DiffFormula: "Hg 1"
xref: DiffMono: "201.970643"
xref: Formula: "C 3 H 5 Hg 1 N 1 O 1 S 1"
xref: MassAvg: "303.73"
xref: MassMono: "304.979828"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:291"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:01075 ! mercury containing modified residue

[Term]
id: MOD:00611
name: iodouridine monophosphate derivatized residue
def: "A protein modification that is produced by reaction of iodouridine monophosphate with a residue." [PubMed:11112526, PubMed:11567090, PubMed:6540775, Unimod:292]
synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED Unimod-description []
synonym: "IodoU-AMP" RELATED PSI-MS-label []
xref: DiffAvg: "322.17"
xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1"
xref: DiffMono: "322.020217"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:292"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00612
name: 3-(carboxamidomethylthio)propanoylated residue
def: "A protein modification that is produced by derivatization of a residue with 3,3-dithiobis[sulfosuccinimidyl propanoate], DTSSP, or with Pierce EZ-Link Sulfo-NHS-SS-Biotin reagent, sulfosuccinimidyl 3-[(2-[biotinamido]ethyl)disulfanyl]propanoate, followed by reduction with dithiothreitol and then reaction with iodoacetamide." [PubMed:15121203, Unimod:293]
synonym: "3-(carbamidomethylthio)propanoyl" RELATED Unimod-description []
synonym: "CAMthiopropanoyl" RELATED PSI-MS-label []
xref: DiffAvg: "145.18"
xref: DiffFormula: "C 5 H 7 N 1 O 2 S 1"
xref: DiffMono: "145.019749"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:293"
is_a: MOD:00649 ! acylated residue
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00613
name: biotinoyl-iodoacetyl-ethylenediamine
def: "modification from Unimod Chemical derivative" [PubMed:10906242, Unimod:294]
synonym: "biotinoyl-iodoacetyl-ethylenediamine" RELATED Unimod-description []
synonym: "IED-Biotin" RELATED PSI-MS-label []
xref: DiffAvg: "326.42"
xref: DiffFormula: "C 14 H 22 N 4 O 3 S 1"
xref: DiffMono: "326.141262"
xref: Formula: "C 17 H 27 N 5 O 4 S 2"
xref: MassAvg: "429.55"
xref: MassMono: "429.150446"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:294"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00614
name: fucosylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a fucose (6-deoxy-D-galactose) group through a glycosidic bond." [PubMed:11344537, PubMed:15189151, Unimod:295]
subset: PSI-MOD-slim
synonym: "dHex" RELATED PSI-MS-label []
synonym: "Fuc" EXACT PSI-MOD-label []
synonym: "Fucose" RELATED Unimod-description []
xref: DiffAvg: "146.14"
xref: DiffFormula: "C 6 H 10 O 4"
xref: DiffMono: "146.057909"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:295"
xref: GNOme: "GNO:G49112ZN"
is_a: MOD:00736 ! deoxyhexosylated residue

[Term]
id: MOD:00615
name: 4-sulfophenyl isothiocyante modification to N-term R
def: "OBSOLETE because entry Unimod:261 site N-term R was abandoned. Remap to MOD:00584" [PubMed:14689565, Unimod:261]
xref: DiffAvg: "215.24"
xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2"
xref: DiffMono: "214.971085"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Remap: "MOD:00584"
xref: Unimod: "Unimod:261"
is_obsolete: true

[Term]
id: MOD:00616
name: residues isobaric at a resolution below 0.1 Da
def: "Natural or modified residues that are isobaric at a resolution below 0.1 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00538 ! protein modification categorized by isobaric sets

[Term]
id: MOD:00617
name: 3x(2)H residue methyl ester
def: "A protein modification that effectively converts a residue containing common isotopes to a 3x(2)H labeled residue methyl ester." [OMSSA:21, Unimod:298]
synonym: "ctermpeptrideuteromethyl" EXACT OMSSA-label []
synonym: "deuterated methyl ester" RELATED Unimod-description []
synonym: "Methyl:2H(3)" RELATED PSI-MS-label []
xref: DiffAvg: "17.03"
xref: DiffFormula: "C 1 (1)H -1 (2)H 3"
xref: DiffMono: "17.034480"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:298"
is_a: MOD:00839 ! (2)H deuterium labeled residue

[Term]
id: MOD:00618
name: tryptophan carboxylation
def: "modification from Unimod Chemical derivative" [Unimod:299#W]
comment: There is no literature citation for this Unimod entry [JSG].
synonym: "Carboxy" RELATED Unimod-interim []
synonym: "Carboxylation" RELATED Unimod-description []
xref: DiffAvg: "44.01"
xref: DiffFormula: "C 1 O 2"
xref: DiffMono: "43.989829"
xref: Formula: "C 12 H 10 N 2 O 3"
xref: MassAvg: "230.22"
xref: MassMono: "230.069142"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:299"
is_a: MOD:00918 ! modified L-tryptophan residue
is_a: MOD:01152 ! carboxylated residue

[Term]
id: MOD:00619
name: hydroxylethanone
def: "OBSOLETE because entry 300 is redundant with Unimod 6 remap to MOD:01328" [Unimod:300]
xref: DiffAvg: "58.04"
xref: DiffFormula: "C 2 H 2 O 2"
xref: DiffMono: "58.005479"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:01328"
xref: Unimod: "Unimod:300"
is_obsolete: true

[Term]
id: MOD:00620
name: cysteine monobromobimane derivative
def: "modification from Unimod Chemical derivative" [PubMed:7856876, Unimod:301]
comment: 1-(bromomethyl)-2,6,7-trimethylpyrazolo[1,2-a]pyrazole-3,5-dione, C 10 H 11 Br 1 N 2 O 2.
synonym: "Bromobimane" RELATED PSI-MS-label []
synonym: "Monobromobimane derivative" RELATED Unimod-description []
xref: DiffAvg: "190.20"
xref: DiffFormula: "C 10 H 10 N 2 O 2"
xref: DiffMono: "190.074228"
xref: Formula: "C 13 H 15 N 3 O 3 S 1"
xref: MassAvg: "293.34"
xref: MassMono: "293.083412"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:301"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00621
name: menadione quinone derivative
def: "modification from Unimod Chemical derivative" [PubMed:15939799, Unimod:302]
synonym: "Menadione" RELATED Unimod-interim []
synonym: "Menadione quinone derivative" RELATED Unimod-description []
xref: DiffAvg: "170.17"
xref: DiffFormula: "C 11 H 6 O 2"
xref: DiffMono: "170.036779"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:302"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00622
name: cysteine mercaptoethanol
def: "modification from Unimod Chemical derivative" [DeltaMass:80, PubMed:12442261, Unimod:303]
comment: From DeltaMass: Average Mass: 76 Average Mass Change:76 PubMed:8019414.
synonym: "Beta mercaptoethanol adduct" EXACT DeltaMass-label []
synonym: "Cysteine mercaptoethanol" RELATED Unimod-description []
synonym: "DeStreak" RELATED PSI-MS-label []
xref: DiffAvg: "76.11"
xref: DiffFormula: "C 2 H 4 O 1 S 1"
xref: DiffMono: "75.998286"
xref: Formula: "C 5 H 9 N 1 O 2 S 2"
xref: MassAvg: "179.25"
xref: MassMono: "179.007471"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:303"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00623
name: fucosylated biantennary (-2 galactose) N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [Unimod:305]
synonym: "dHex(1)Hex(3)HexNAc(4)" RELATED PSI-MS-label []
synonym: "Fucosylated biantennary (-2 galactose)" RELATED Unimod-description []
xref: DiffAvg: "1443.33"
xref: DiffFormula: "C 56 H 90 N 4 O 39"
xref: DiffMono: "1442.518219"
xref: Formula: "C 60 H 96 N 6 O 41"
xref: MassAvg: "1557.43"
xref: MassMono: "1556.561147"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:305"
xref: GNOme: "GNO:G25987BV"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00624
name: residues isobaric at 113.0-113.1 Da
def: "Natural or modified residues with a mass of 113.0-113.1 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da

[Term]
id: MOD:00625
name: N-methylmaleimide derivatized residue
def: "modification from Unimod Chemical derivative" [Unimod:314]
synonym: "Nmethylmaleimide" RELATED PSI-MS-label []
synonym: "Nmethylmaleimide" RELATED Unimod-description []
xref: DiffAvg: "111.10"
xref: DiffFormula: "C 5 H 5 N 1 O 2"
xref: DiffMono: "111.032028"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:314"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00626
name: fluorescein-5-thiosemicarbazide modified residue
def: "modification from Unimod Chemical derivative" [PubMed:2883911, Unimod:478]
synonym: "fluorescein-5-thiosemicarbazide" RELATED Unimod-description []
synonym: "FTC" RELATED PSI-MS-label []
xref: DiffAvg: "421.43"
xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1"
xref: DiffMono: "421.073242"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:478"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00627
name: 2,5-dimethylpyrrole lysine from 2,5-hexanedione adduct
def: "modification from Unimod Chemical derivative" [Unimod:316]
comment: There is no citation for this Unimod entry. Add PubMed:7981420, correct spelling [JSG].
synonym: "(2S)-2-amino-6-(2,5-dimethylpyrrolidin-1-yl)hexanoic acid" EXACT PSI-MOD-alternate []
synonym: "2,5-dimethypyrrole" RELATED Unimod-description []
synonym: "6-(2,5-dimethylpyrrolidin-1-yl)norleucine" EXACT PSI-MOD-alternate []
synonym: "DimethylpyrroleAdduct" RELATED PSI-MS-label []
xref: DiffAvg: "78.11"
xref: DiffFormula: "C 6 H 6"
xref: DiffMono: "78.046950"
xref: Formula: "C 12 H 18 N 2 O 1"
xref: MassAvg: "206.29"
xref: MassMono: "206.141913"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:316"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00628
name: Hex2
def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with two hexose sugar groups through glycosidic bonds" [PubMed:18688235]
xref: DiffAvg: "324.28"
xref: DiffFormula: "C 12 H 20 O 10"
xref: DiffMono: "324.105647"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: GNOme: "GNO:G90627TW"
is_a: MOD:00725 ! complex glycosylation

[Term]
id: MOD:00629
name: MDA adduct +62
def: "modification from Unimod Chemical derivative" [Unimod:318]
comment: Usually major adduct formed from malondialdehyde (MDA) with the amino group of lysine residues [UniProt].
synonym: "Delta:H(2)C(5)" RELATED PSI-MS-label []
synonym: "MDA adduct +62" RELATED Unimod-description []
xref: DiffAvg: "62.07"
xref: DiffFormula: "C 5 H 2"
xref: DiffMono: "62.015650"
xref: Formula: "C 11 H 14 N 2 O 1"
xref: MassAvg: "190.25"
xref: MassMono: "190.110613"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:318"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00630
name: C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine.
def: "modification from Unimod Chemical derivative" [PubMed:9328283, Unimod:319]
comment: This is not a legitimate ontological entry and will become obsolete when the children are reassigned [JSG]
synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label []
synonym: "MDA adduct +54" RELATED Unimod-description []
xref: DiffAvg: "54.05"
xref: DiffFormula: "C 3 H 2 O 1"
xref: DiffMono: "54.010565"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:319"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00631
name: hydrolyzed N-ethylmaleimide adduct
def: "modification from Unimod Chemical derivative" [Unimod:320]
comment: N-ethylmaeimide adduct + H20 (a mixture of isobaric products) [JSG].
synonym: "Nethylmaleimide+water" RELATED PSI-MS-label []
synonym: "Nethylmaleimidehydrolysis" RELATED Unimod-description []
xref: DiffAvg: "143.14"
xref: DiffFormula: "C 6 H 9 N 1 O 3"
xref: DiffMono: "143.058243"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:320"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00632
name: N-succinimide
def: "OBSOLETE because this chemical derivative modification from Unimod 321 is deprecated." [Unimod:321]
xref: DiffAvg: "-17.01"
xref: DiffFormula: "H -1 O -1"
xref: DiffMono: "-17.002740"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "N"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:321"
is_obsolete: true

[Term]
id: MOD:00633
name: bis-N-I-sulfonerahodamine
def: "modification from Unimod Chemical derivative" [Unimod:323]
comment: Invitrogen B-10621, a red fluorescent cross-linking reagent (only link to Cys is indicated) [Unimod].
synonym: "bis-((N-iodoacetyl)piperazinyl)sulfonerhodamine" EXACT PSI-MOD-alternate []
synonym: "bis-N-I-sulfonerahodamine" RELATED Unimod-description []
synonym: "Xlink:B10621" RELATED PSI-MS-label []
xref: DiffAvg: "713.57"
xref: DiffFormula: "C 31 H 30 I 1 N 4 O 6 S 1"
xref: DiffMono: "713.093078"
xref: Formula: "C 34 H 35 I 1 N 5 O 7 S 2"
xref: MassAvg: "816.71"
xref: MassMono: "816.102263"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:323"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00634
name: dimethyl 3,3'-dithiobispropionimidate
def: "modification from Unimod Chemical derivative" [PubMed:770170, Unimod:324]
comment: Pierce reagent, needs sites for N, Q, R, K, and N-term [JSG].
synonym: "dimethyl 3,3'-dithiobispropionimidate" RELATED Unimod-description []
synonym: "DTBP" RELATED Unimod-interim []
xref: DiffAvg: "123.60"
xref: DiffFormula: "C 3 Cl 1 H 6 N 1 S 1"
xref: DiffMono: "122.990948"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:324"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00635
name: 10-fluoroethoxyphosphinyl-N-(biotinamidopentyl)decanamide
def: "modification from Unimod Chemical derivative" [PubMed:10611275, Unimod:325]
synonym: "10-ethoxyphosphinyl-N-(biotinamidopentyl)decanamide" RELATED Unimod-description []
synonym: "FP-Biotin" RELATED Unimod-interim []
xref: DiffAvg: "572.75"
xref: DiffFormula: "C 27 H 49 N 4 O 5 P 1 S 1"
xref: DiffMono: "572.316128"
xref: Formula: "C 30 H 54 N 5 O 7 P 1 S 1"
xref: MassAvg: "659.82"
xref: MassMono: "659.348157"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:325"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00636
name: S-ethylcysteine (Ser)
def: "A protein modification that effectively converts an L-serine residue to S-ethylcysteine." [Unimod:327]
comment: Modification from Unimod. Phosphoserine is converted to dehydroalanine then by Michael addition of ethanethiol to S-ethylcysteine. Needs parent and sibling for S-ethyl-cysteine.
synonym: "Delta:H(4)C(2)O(-1)S(1)" RELATED PSI-MS-label []
synonym: "S-Ethylcystine from Serine" RELATED Unimod-description []
xref: DiffAvg: "44.11"
xref: DiffFormula: "C 2 H 4 O -1 S 1"
xref: DiffMono: "44.008457"
xref: Formula: "C 5 H 9 N 1 O 1 S 1"
xref: MassAvg: "131.19"
xref: MassMono: "131.040485"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:327"
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00637
name: 1x(13)C,3x(2)H labeled monomethylated L-arginine
def: "A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with a (13)C,3x(2)H labeled methyl group to form a 1x(13)C,3x(2)H labeled monomethylated L-arginine." [Unimod:329]
synonym: "Methyl:2H(3)13C(1)" RELATED PSI-MS-label []
synonym: "monomethylated arginine" RELATED Unimod-description []
xref: DiffAvg: "18.04"
xref: DiffFormula: "(13)C 1 (1)H -1 (2)H 3"
xref: DiffMono: "18.037835"
xref: Formula: "(12)C 6 (13)C 1 (1)H 11 (2)H 3 N 4 O 1"
xref: MassAvg: "174.14"
xref: MassMono: "174.138946"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:329"
is_a: MOD:00839 ! (2)H deuterium labeled residue
is_a: MOD:00842 ! (13)C labeled residue
is_a: MOD:00902 ! modified L-arginine residue
relationship: derives_from MOD:00414 ! monomethylated L-arginine

[Term]
id: MOD:00638
name: 2x(13)C,6x(2)H labeled dimethylated L-arginine
def: "A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-arginine." [PubMed:15782174, Unimod:330]
synonym: "Dimethyl:2H(6)13C(2)" RELATED PSI-MS-label []
synonym: "dimethylated arginine" RELATED Unimod-description []
xref: DiffAvg: "36.08"
xref: DiffFormula: "(13)C 2 (1)H -2 (2)H 6"
xref: DiffMono: "36.075670"
xref: Formula: "(12)C 6 (13)C 2 (1)H 10 (2)H 6 N 4 O 1"
xref: MassAvg: "192.18"
xref: MassMono: "192.176781"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:330"
is_a: MOD:00839 ! (2)H deuterium labeled residue
is_a: MOD:00842 ! (13)C labeled residue
is_a: MOD:00902 ! modified L-arginine residue
relationship: derives_from MOD:00783 ! dimethylated L-arginine

[Term]
id: MOD:00639
name: thiophosphate labeled with biotin-HPDP
def: "modification from Unimod Chemical derivative" [Unimod:332]
synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label []
synonym: "thiophosphate labeled with biotin-HPDP" RELATED Unimod-description []
xref: DiffAvg: "525.66"
xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3"
xref: DiffMono: "525.142895"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:332"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00861 ! phosphorus containing modified residue

[Term]
id: MOD:00640
name: 6-N-biotinylaminohexyl isopropyl phosphorofluoridate
def: "modification from Unimod Chemical derivative" [Unimod:333]
synonym: "6-N-biotinylaminohexyl isopropyl phosphate" RELATED Unimod-description []
synonym: "Can-FP-biotin" RELATED Unimod-interim []
xref: DiffAvg: "467.54"
xref: DiffFormula: "C 19 F 1 H 35 N 3 O 5 P 1 S 1"
xref: DiffMono: "467.201907"
xref: Formula: "C 22 F 1 H 40 N 4 O 7 P 1 S 1"
xref: MassAvg: "554.62"
xref: MassMono: "554.233935"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:333"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00641
name: CAMthiopropanoyl of Lys
def: "OBSOLETE because Unimod entry 334 is merged with Unimod 293. Remap to MOD:00612" [Unimod:334]
xref: DiffAvg: "146.18"
xref: DiffFormula: "C 5 H 8 N 1 O 2 S 1"
xref: DiffMono: "146.027574"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00612"
xref: Unimod: "Unimod:334"
is_obsolete: true

[Term]
id: MOD:00642
name: reduced 4-hydroxynonenal adduct
def: "A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:15133838, Unimod:335]
comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG].
synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label []
synonym: "reduced 4-Hydroxynonenal" RELATED Unimod-description []
xref: DiffAvg: "158.24"
xref: DiffFormula: "C 9 H 18 O 2"
xref: DiffMono: "158.130680"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:335"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:01155 ! lipoconjugated residue
relationship: derives_from MOD:00446 ! 4-hydroxynonenal adduct

[Term]
id: MOD:00643
name: methylamine Michael addition derivatized residue
def: "modification from Unimod Artifact" [PubMed:11968134, Unimod:337]
synonym: "Methylamine" RELATED PSI-MS-label []
synonym: "Michael addition with methylamine" RELATED Unimod-description []
xref: DiffAvg: "13.04"
xref: DiffFormula: "C 1 H 3 N 1 O -1"
xref: DiffMono: "13.031634"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:337"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00644
name: mono O-acetylated residue
def: "A protein modification that effectively replaces a residue hydroxyl group with an acetoxy group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OAcRes" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00394 ! monoacetylated residue
is_a: MOD:00671 ! O-acylated residue

[Term]
id: MOD:00645
name: mono S-acetylated residue
def: "A protein modification that effectively replaces a residue sulfanyl group with an acetylsulfanyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "SAcRes" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 O 1 S 0"
xref: DiffMono: "42.010565"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00394 ! monoacetylated residue
is_a: MOD:00672 ! S-acylated residue

[Term]
id: MOD:00646
name: monoacetylated L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to either N-acetyl-L-cysteine or S-acetyl-L-cysteine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "AcCys" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1 S 0"
xref: DiffMono: "42.010565"
xref: Formula: "C 5 H 7 N 1 O 2 S 1"
xref: MassAvg: "145.18"
xref: MassMono: "145.019749"
xref: Origin: "C"
xref: Source: "natural"
is_a: MOD:00394 ! monoacetylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00647
name: monoacetylated L-serine
def: "A protein modification that effectively converts an L-serine residue to either N-acetyl-L-serine, O-acetyl-L-serine, or N,O-diacetyl-L-serine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "AcSer" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "S"
xref: Source: "natural"
is_a: MOD:00394 ! monoacetylated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00648
name: N,O-diacetylated L-serine
def: "A protein modification that effectively converts an L-serine residue to N,O-diacetyl-L-serine." [PubMed:16731519, PubMed:489587, PubMed:7309355, RESID:AA0051#var, RESID:AA0364#var]
comment: In one paper, the samples were prepared using glacial acetic acid, and were probably artifactual [JSG].
synonym: "(S)-2-acetamido-3-acetyloxypropanoic acid" EXACT PSI-MOD-alternate []
synonym: "N,O-diacetyl-L-serine" EXACT PSI-MOD-alternate []
synonym: "N,O-diacetylserine" EXACT PSI-MOD-alternate []
synonym: "NOAc2Ser" EXACT PSI-MOD-label []
xref: DiffAvg: "84.07"
xref: DiffFormula: "C 4 H 4 N 0 O 2"
xref: DiffMono: "84.021129"
xref: Formula: "C 7 H 10 N 1 O 4"
xref: MassAvg: "172.16"
xref: MassMono: "172.060983"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:02080 ! diacetylated L-serine
relationship: has_functional_parent MOD:00060 ! N-acetyl-L-serine
relationship: has_functional_parent MOD:00369 ! O-acetyl-L-serine

[Term]
id: MOD:00649
name: acylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an acyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "AcylRes" EXACT PSI-MOD-label []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00650
name: N-myristoylated residue
def: "A protein modification that effectively replaces a residue amino group with a myristoylamino group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "NMyrRes" EXACT PSI-MOD-label []
xref: DiffAvg: "210.36"
xref: DiffFormula: "C 14 H 26 O 1"
xref: DiffMono: "210.198365"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00438 ! myristoylated residue
is_a: MOD:00670 ! N-acylated residue

[Term]
id: MOD:00651
name: N-palmitoylated residue
def: "A protein modification that effectively replaces a residue amino group with a palmitoylamino group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "NPamRes" EXACT PSI-MOD-label []
synonym: "N-hexadecanoylated residue" EXACT PSI-MOD-alternate []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 O 1"
xref: DiffMono: "238.229666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00440 ! palmitoylated residue
is_a: MOD:00670 ! N-acylated residue

[Term]
id: MOD:00652
name: O-palmitoylated residue
def: "A protein modification that effectively replaces a residue hydroxyl group with a palmitoyloxy group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OPamRes" EXACT PSI-MOD-label []
synonym: "O-hexadecanoylated residue" EXACT PSI-MOD-alternate []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 O 1"
xref: DiffMono: "238.229666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00440 ! palmitoylated residue
is_a: MOD:00671 ! O-acylated residue

[Term]
id: MOD:00653
name: S-palmitoylated residue
def: "A protein modification that effectively replaces a residue sulfanyl group with an palmitoylsulfanyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "SPamRes" EXACT PSI-MOD-label []
synonym: "S-hexadecanoylated residue" EXACT PSI-MOD-alternate []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 O 1 S 0"
xref: DiffMono: "238.229666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00440 ! palmitoylated residue
is_a: MOD:00672 ! S-acylated residue

[Term]
id: MOD:00654
name: S-methylated residue
def: "a protein modification that effectively replaces a sulfanyl group with a methylsulfanyl group" [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "SMeRes" EXACT PSI-MOD-label []
is_a: MOD:00427 ! methylated residue

[Term]
id: MOD:00655
name: S-myristoylated residue
def: "A protein modification that effectively replaces a residue sulfanyl group with an myristoylsulfanyl group." [PubMed:18688235]
synonym: "SMyrRes" EXACT PSI-MOD-label []
xref: DiffAvg: "210.36"
xref: DiffFormula: "C 14 H 26 O 1 S 0"
xref: DiffMono: "210.198365"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00438 ! myristoylated residue
is_a: MOD:00672 ! S-acylated residue

[Term]
id: MOD:00656
name: C-methylated residue
def: "A protein modification that effectively replaces a residue hydrocarbyl hydrogen with an methyl group." [PubMed:18688235]
synonym: "CMeRes" EXACT PSI-MOD-label []
is_a: MOD:00427 ! methylated residue

[Term]
id: MOD:00657
name: L-glutamic acid 5-methyl ester (Gln)
def: "A protein modification that effectively converts an L-glutamine residue to L-glutamate 5-methyl ester." [PubMed:16888, PubMed:6300110, RESID:AA0072#GLN, Unimod:528]
comment: This is known to be a natural modification of glutamine in prokaryotes.
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-methoxy-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "(5)-methyl L-hydrogen glutamate" EXACT RESID-alternate []
synonym: "2-aminopentanedioic acid 5-methyl ester" EXACT RESID-alternate []
synonym: "5-methyl L-2-aminoglutarate" EXACT RESID-alternate []
synonym: "5-methyl L-glutamate" EXACT RESID-alternate []
synonym: "deamidated 5-methyl esterified glutamine" EXACT PSI-MOD-alternate []
synonym: "Deamidation followed by a methylation" RELATED Unimod-description []
synonym: "glutamic acid 5-methyl ester" EXACT RESID-alternate []
synonym: "glutamic acid gamma-methyl ester" EXACT RESID-alternate []
synonym: "L-glutamic acid 5-methyl ester" EXACT RESID-name []
synonym: "Methyl+Deamidated" RELATED PSI-MS-label []
synonym: "MOD_RES Glutamate methyl ester (Gln)" EXACT UniProt-feature []
synonym: "O5MeGlu(Gln)" EXACT PSI-MOD-label []
xref: DiffAvg: "15.01"
xref: DiffFormula: "C 1 H 1 N -1 O 1"
xref: DiffMono: "14.999666"
xref: Formula: "C 6 H 9 N 1 O 3"
xref: MassAvg: "143.14"
xref: MassMono: "143.058243"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:528"
xref: uniprot.ptm:PTM-0127
is_a: MOD:01369 ! deamidated and methyl esterified residue
is_a: MOD:01453 ! L-glutamic acid 5-methyl ester
relationship: has_functional_parent MOD:00659 ! methylated glutamine

[Term]
id: MOD:00658
name: methylated arginine
def: "A protein modification that effectively converts an L-arginine residue to a methylated arginine, either 5-methylargine, N5-methylarginine, or an omega-N-methylated L-arginine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeArg" EXACT PSI-MOD-label []
xref: Origin: "R"
xref: uniprot.ptm:PTM-0238
is_a: MOD:00427 ! methylated residue
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00659
name: methylated glutamine
def: "A protein modification that effectively converts an L-glutamine residue to a methylated glutamine, either 2-methylated glutamine, N5-methylated glutamine, or methyl esterified deamidated glutamine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeGln" EXACT PSI-MOD-label []
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00907 ! modified L-glutamine residue

[Term]
id: MOD:00660
name: methylated cysteine
def: "A protein modification that effectively converts an L-cysteine residue to a methylated cysteine, either S-methylcysteine, or cysteine methyl ester." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeCys" EXACT PSI-MOD-label []
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00661
name: methylated histidine
def: "A protein modification that effectively converts an L-histidine residue to a methylated histidine, such as pros-methylhistidine, or tele-methylhistidine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeHis" EXACT PSI-MOD-label []
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:00662
name: methylated leucine
def: "A protein modification that effectively converts an L-leucine residue to a methylated leucine, either N-methylleucine, or leucine methyl ester." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeLeu" EXACT PSI-MOD-label []
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00911 ! modified L-leucine residue

[Term]
id: MOD:00663
name: methylated lysine
def: "A protein modification that effectively converts an L-lysine residue to a methylated lysine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeLys" EXACT PSI-MOD-label []
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0193
is_a: MOD:00427 ! methylated residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00664
name: stereoisomerized residue
def: "A protein modification that effectively replaces a residue L-enantiomer (stereoisomer) with a D-enantiomer or with a different diastereomeric isomer." [PubMed:18688235]
synonym: "D-Res" EXACT PSI-MOD-label []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00665
name: methylated alanine
def: "A protein modification that effectively converts an L-alanine residue to a methylated alanine, such as N-methylalanine, N,N-dimethylalanine, or N,N,N-trimethylalanine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeAla" EXACT PSI-MOD-label []
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00901 ! modified L-alanine residue

[Term]
id: MOD:00666
name: octanoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an octanoyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OctRes" EXACT PSI-MOD-label []
xref: DiffAvg: "126.20"
xref: DiffFormula: "C 8 H 14 N 0 O 1"
xref: DiffMono: "126.104465"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00667
name: decanoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a decanoyl group." [PubMed:18688235]
synonym: "DecRes" EXACT PSI-MOD-label []
xref: DiffAvg: "154.25"
xref: DiffFormula: "C 10 H 18 N 0 O 1"
xref: DiffMono: "154.135765"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00668
name: O-decanoylated residue
def: "A protein modification that effectively replaces a residue hydroxyl group with a decanoyloxy group." [Unimod:449]
synonym: "Decanoyl" RELATED PSI-MS-label []
synonym: "lipid" RELATED Unimod-description []
synonym: "ODecRes" EXACT PSI-MOD-label []
xref: DiffAvg: "154.25"
xref: DiffFormula: "C 10 H 18 N 0 O 1"
xref: DiffMono: "154.135765"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:449"
is_a: MOD:00667 ! decanoylated residue
is_a: MOD:00671 ! O-acylated residue

[Term]
id: MOD:00669
name: O-octanoylated residue
def: "A protein modification that effectively replaces a residue hydroxyl group with a octanoyloxy group." [Unimod:426]
subset: PSI-MOD-slim
synonym: "Octanoyl" RELATED PSI-MS-label []
synonym: "octanoyl" RELATED Unimod-description []
synonym: "OOctRes" EXACT PSI-MOD-label []
xref: DiffAvg: "126.20"
xref: DiffFormula: "C 8 H 14 N 0 O 1"
xref: DiffMono: "126.104465"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:426"
is_a: MOD:00666 ! octanoylated residue
is_a: MOD:00671 ! O-acylated residue

[Term]
id: MOD:00670
name: N-acylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "NAcylRes" EXACT PSI-MOD-label []
is_a: MOD:00649 ! acylated residue

[Term]
id: MOD:00671
name: O-acylated residue
def: "A protein modification that effectively replaces a residue hydroxyl group with a acyloxy group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OAcylRes" EXACT PSI-MOD-label []
is_a: MOD:00649 ! acylated residue

[Term]
id: MOD:00672
name: S-acylated residue
def: "A protein modification that effectively replaces a residue sulfanyl group with an acylsulfanyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "SAcylRes" EXACT PSI-MOD-label []
is_a: MOD:00649 ! acylated residue

[Term]
id: MOD:00673
name: methylated asparagine
def: "A protein modification that effectively converts an L-asparagine residue to a methylated asparagine, such as N4-methyl-L-asparagine, or N4,N4-dimethyl-L-asparagine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeAsn" EXACT PSI-MOD-label []
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:00674
name: amidated residue
def: "A protein modification that effectively replaces a carboxyl group with a carboxamido group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00675
name: oxidized residue
def: "A protein modification that effectively either removes neutral hydrogen atoms (proton and electron), or adds oxygen atoms to a residue with or without the removal of hydrogen atoms." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OxRes" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00676
name: oxygenated residue
def: "A protein modification that effectively adds oxygen atoms to a residue with or without the removal of hydrogen atoms." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OxyRes" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00675 ! oxidized residue

[Term]
id: MOD:00677
name: hydroxylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an hydroxyl group." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 16
subset: PSI-MOD-slim
synonym: "Hydroxylation (of delta C of Lysine, beta C of Tryptophan, C3 or C4 of Proline, beta C of Aspartate)" EXACT DeltaMass-label []
synonym: "HyRes" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00679 ! carbon oxygenated residue

[Term]
id: MOD:00678
name: hydroxylated proline
def: "A protein modification that effectively converts an L-proline residue to an hydroxylated L-proline." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "HyPro" EXACT PSI-MOD-label []
xref: Origin: "P"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00677 ! hydroxylated residue
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:00679
name: carbon oxygenated residue
def: "A protein modification that effectively adds oxygen atoms to a carbon atom of a residue and removes hydrogen atoms." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "COxyRes" EXACT PSI-MOD-label []
is_a: MOD:00676 ! oxygenated residue

[Term]
id: MOD:00680
name: sulfur oxygenated residue
def: "A protein modification that effectively adds oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "SOxyRes" EXACT PSI-MOD-label []
is_a: MOD:00676 ! oxygenated residue

[Term]
id: MOD:00681
name: hydroxylated lysine
def: "A protein modification that effectively converts an L-lysine residue to a hydroxylated L-lysine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "HyLys" EXACT PSI-MOD-label []
xref: Origin: "K"
is_a: MOD:00677 ! hydroxylated residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00682
name: hydroxylated arginine
def: "A protein modification that effectively converts an L-arginine residue to a hydroxylated L-arginine." [PubMed:18688235]
synonym: "HyArg" EXACT PSI-MOD-label []
xref: Origin: "R"
xref: uniprot.ptm:PTM-0498
is_a: MOD:00677 ! hydroxylated residue
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00683
name: dehydrogenated residue
def: "A protein modification that effectively removes neutral hydrogen atoms (proton and electron) from a residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "dHRes" EXACT PSI-MOD-label []
xref: Origin: "X"
is_a: MOD:00675 ! oxidized residue

[Term]
id: MOD:00684
name: deamidated L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to L-aspartic acid." [PubMed:1097438, PubMed:339692, PubMed:4399050, PubMed:5764436, PubMed:6692818, PubMed:8089117, PubMed:9521123, PubMed:9582379, RESID:AA0004#ASN, Unimod:7#N]
comment: incidental to RESID:AA0059
subset: PSI-MOD-slim
synonym: "(2S)-2-aminobutanedioic acid" EXACT RESID-systematic []
synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate []
synonym: "aminosuccinic acid" EXACT RESID-alternate []
synonym: "dNAsn" EXACT PSI-MOD-label []
synonym: "L-aspartic acid" EXACT RESID-name []
synonym: "MOD_RES Deamidated asparagine" EXACT UniProt-feature []
xref: DiffAvg: "0.98"
xref: DiffFormula: "C 0 H -1 N -1 O 1"
xref: DiffMono: "0.984016"
xref: Formula: "C 4 H 5 N 1 O 3"
xref: MassAvg: "115.09"
xref: MassMono: "115.026943"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:7"
xref: uniprot.ptm:PTM-0116
is_a: MOD:00400 ! deamidated residue
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:00685
name: deamidated L-glutamine
def: "A protein modification that effectively converts an L-glutamine residue to L-glutamic acid." [PubMed:1881881, PubMed:4565668, PubMed:4922541, PubMed:6692818, PubMed:9192900, PubMed:957425, RESID:AA0006#GLN, Unimod:7#Q]
subset: PSI-MOD-slim
synonym: "(2S)-2-aminopentanedioic acid" EXACT RESID-systematic []
synonym: "1-aminopropane-1,3-dicarboxylic acid" EXACT RESID-alternate []
synonym: "2-aminoglutaric acid" EXACT RESID-alternate []
synonym: "2-azanylpentanedioic acid" EXACT RESID-alternate []
synonym: "alpha-aminoglutaric acid" EXACT RESID-alternate []
synonym: "dNGln" EXACT PSI-MOD-label []
synonym: "glutaminic acid" EXACT RESID-alternate []
synonym: "L-glutamic acid" EXACT RESID-name []
synonym: "MOD_RES Deamidated glutamine" EXACT UniProt-feature []
xref: DiffAvg: "0.98"
xref: DiffFormula: "C 0 H -1 N -1 O 1"
xref: DiffMono: "0.984016"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:7"
xref: uniprot.ptm:PTM-0117
is_a: MOD:00400 ! deamidated residue
is_a: MOD:00907 ! modified L-glutamine residue

[Term]
id: MOD:00686
name: L-selenocysteine (Cys)
def: "A protein modification that effectively converts an L-cysteine residue to L-selenocysteine (not known as a natural, post-translational modification process)." [PubMed:10523135, PubMed:2037562, PubMed:2963330, PubMed:6217842, PubMed:6714945, RESID:AA0022#CYS, Unimod:162#C]
comment: This entry is for the artifactual formation of L-selenocysteine from cysteine. For encoded L-selenocysteine, use MOD:00031 [JSG].
synonym: "(2R)-2-amino-3-selanylpropanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-selanylpropanoic acid" EXACT RESID-alternate []
synonym: "3-selenylalanine" EXACT RESID-alternate []
synonym: "L-selenocysteine" EXACT RESID-name []
synonym: "NON_STD Selenocysteine" EXACT UniProt-feature []
synonym: "Sec(Cys)" EXACT PSI-MOD-label []
synonym: "SeCys" EXACT RESID-alternate []
synonym: "selenium cysteine" EXACT RESID-alternate []
xref: DiffAvg: "46.91"
xref: DiffFormula: "C 0 H 0 N 0 O 0 S -1 Se 1"
xref: DiffMono: "47.944450"
xref: Formula: "C 3 H 5 N 1 O 1 Se 1"
xref: MassAvg: "150.05"
xref: MassMono: "150.953635"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:162"
is_a: MOD:00007 ! selenium substitution for sulfur
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00687
name: thioether crosslinked residues
def: "A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and either an alkyl C as in lanthionine, or an aryl C as 2'-(S-cysteinyl)-L-histidine." [PubMed:18688235]
is_a: MOD:00033 ! crosslinked residues
is_a: MOD:02044 ! crosslinked L-cysteine residue

[Term]
id: MOD:00688
name: isopeptide crosslinked residues
def: "A protein modification that crosslinks two residues with an amide bond where either the donor amino or carboxyl is not an alpha group." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00033 ! crosslinked residues

[Term]
id: MOD:00689
name: disulfide crosslinked residues
def: "A protein modification that crosslinks two cysteine residues by formation of a disulfide bond." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01619 ! multisulfide crosslinked residues

[Term]
id: MOD:00690
name: oxazole/thiazole ring crosslinked residues
def: "A protein modification that crosslinks two residues by formation of an oxazole or thiazole ring." [PubMed:18688235]
is_a: MOD:00033 ! crosslinked residues

[Term]
id: MOD:00691
name: 5-imidazolinone ring crosslinked residues
def: "A protein modification that crosslinks two residues by formation of an 5-imidazolinone ring." [PubMed:18688235]
is_a: MOD:00033 ! crosslinked residues

[Term]
id: MOD:00692
name: uncategorized crosslinked residues
def: "A protein crosslink modification that is not chemically categorized." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00033 ! crosslinked residues

[Term]
id: MOD:00693
name: glycosylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "GlycoRes" EXACT PSI-MOD-label []
xref: Source: "natural"
is_a: MOD:00764 ! glycoconjugated residue

[Term]
id: MOD:00694
name: halogen containing residue
def: "A protein modification that effectively substitutes a halogen atom for a hydrogen atom." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "halogenated residue" EXACT PSI-MOD-alternate []
synonym: "HalRes" EXACT PSI-MOD-label []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00695
name: sulfated residue
def: "A protein modification that effectively substitutes a sulfonyl group for the hydrogen atom of a hydroxyl or sulfanyl group." [DeltaMass:0, PubMed:14752058, Unimod:40]
comment: From DeltaMass: Average Mass: 80.
subset: PSI-MOD-slim
synonym: "O-Sulfonation" RELATED Unimod-description []
synonym: "Sulfo" RELATED PSI-MS-label []
synonym: "SulfRes" EXACT PSI-MOD-label []
synonym: "Sulphonation (SO3H) (of PMC group)" EXACT DeltaMass-label []
xref: DiffAvg: "80.06"
xref: DiffFormula: "O 3 S 1"
xref: DiffMono: "79.956815"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:40"
is_a: MOD:00860 ! sulfur containing modified residue

[Term]
id: MOD:00696
name: phosphorylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a phosphono group (H2PO3 or 'phosphate')." [DeltaMass:0, Unimod:21]
comment: From DeltaMass: Average Mass: 80.
subset: PSI-MOD-slim
synonym: "Phospho" RELATED PSI-MS-label []
synonym: "Phosphorylation" RELATED Unimod-description []
synonym: "Phosphorylation (O of Serine, Threonine, Tyrosine and Aspartate, N epsilon of Lysine)" EXACT DeltaMass-label []
synonym: "PhosRes" EXACT PSI-MOD-label []
xref: DiffAvg: "79.98"
xref: DiffFormula: "H 1 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:21"
is_a: MOD:00861 ! phosphorus containing modified residue

[Term]
id: MOD:00697
name: flavin modified residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a flavin group." []
subset: PSI-MOD-slim
synonym: "FAD" RELATED PSI-MS-label []
synonym: "Flavin adenine dinucleotide" RELATED Unimod-description []
synonym: "FlavRes" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00698
name: metal or metal cluster containing modified residue
def: "A protein modification that effectively substitutes a metal atom or a metal cluster for hydrogen atoms, or coordinates a metal ion." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MetalRes" EXACT PSI-MOD-label []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00699
name: porphyrin modified residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a porphyrin group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "PorphRes" EXACT PSI-MOD-label []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00700
name: tetrapyrrole modified residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a tetrapyrrole group." [PubMed:18688235]
synonym: "TetrapyrRes" EXACT PSI-MOD-label []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00701
name: nucleotide or nucleic acid modified residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a nucleotide or a polynucleotide through formation of either a phosphodiester bond, a phosphoramide ester bond, or a glycosidic bond." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "NucRes" EXACT PSI-MOD-label []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00702
name: isotope labeled residue
def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms or groups containing isotopes that are not the most common." [PubMed:18688235]
comment: In SILAC (stable isotope labelling of amino acids in cell culture), the label may be introduced either through labeling of an incorporated residue or labeling of the substrates in a metabolic modification. For isotope labeling introduced through a modification reagent see MOD:01426.
subset: PSI-MOD-slim
synonym: "IsoTagRes" EXACT PSI-MOD-label []
synonym: "SILAC" EXACT PSI-MOD-alternate []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00703
name: isoprenylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20) group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "IpRes" EXACT PSI-MOD-label []
is_a: MOD:00001 ! alkylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00704
name: dehydrated residue
def: "A protein modification that effectively forms a double bond by removing a molecule of water from a residue." [DeltaMass:0, Unimod:23]
subset: PSI-MOD-slim
synonym: "Dehydrated" RELATED Unimod-interim []
synonym: "Dehydration" RELATED Unimod-description []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:23"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00705
name: D-valine
def: "A protein modification that effectively converts an L-valine residue to D-valine." [ChEBI:30016, PubMed:15853325, RESID:AA0200]
synonym: "(R)-2-amino-3-methylbutanoic acid" EXACT RESID-systematic []
synonym: "alpha-amino-beta-methylbutyric acid" EXACT RESID-alternate []
synonym: "alpha-aminoisovaleric acid" EXACT RESID-alternate []
synonym: "D-Val" EXACT PSI-MOD-label []
synonym: "D-valine" EXACT RESID-name []
synonym: "MOD_RES D-valine" EXACT UniProt-feature []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 5 H 9 N 1 O 1"
xref: MassAvg: "99.13"
xref: MassMono: "99.068414"
xref: Origin: "V"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0124
is_a: MOD:00664 ! stereoisomerized residue

[Term]
id: MOD:00706
name: dehydrogenated tyrosine
def: "A protein modification that effectively converts L-tyrosine to 2,3-didehydrotyrosine." [Unimod:401#Y]
subset: PSI-MOD-slim
synonym: "dHTyr" EXACT PSI-MOD-label []
synonym: "MOD_RES 2,3-didehydrotyrosine" EXACT UniProt-feature []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 9 H 7 N 1 O 2"
xref: MassAvg: "161.16"
xref: MassMono: "161.047678"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:401"
xref: uniprot.ptm:PTM-0008
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01888 ! didehydrogenated residue

[Term]
id: MOD:00707
name: hydroxylated tyrosine
def: "a protein modification that effectively converts an L-tyrosine residue to a multihydroxylated L-phenylalanine" [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "HyTyr" EXACT PSI-MOD-label []
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00677 ! hydroxylated residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00708
name: sulfur oxygenated L-cysteine
def: "A protein modification that effectively adds oxygen atoms to a sulfur atom of L-cysteine residue without removing hydrogen atoms." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "SOxyCys" EXACT PSI-MOD-label []
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00680 ! sulfur oxygenated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00709
name: sulfur oxygenated L-methionine
def: "A protein modification that effectively adds oxygen atoms to a sulfur atom of L-methionine residue without removing hydrogen atoms." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "SOxyMet" EXACT PSI-MOD-label []
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00680 ! sulfur oxygenated residue
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:00710
name: protonated-dimethylated residue
def: "A protein modification that effectively adds a proton and replaces two hydrogen atoms with two methyl groups." [PubMed:18688235]
comment: For N-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts for both protonation and dimethylation. The alternative Me2Res process accounts only for dimethylation and not protonation.
subset: PSI-MOD-slim
synonym: "Me2+Res" EXACT PSI-MOD-label []
is_a: MOD:00429 ! dimethylated residue

[Term]
id: MOD:00711
name: trimethylated protonated-residue
def: "A protein modification that effectively replaces three hydrogen atoms with three methyl groups, after a proton has been added to form an aminium group." [PubMed:18688235]
comment: For amino acids residues, amine trimethylation can effectively only be accomplished with a protonated primary amino group. This process accounts for both protonation and trimethylation. The alternative Me3Res process accounts only for trimethylation and not protonation.
subset: PSI-MOD-slim
synonym: "Me3+Res" EXACT PSI-MOD-label []
xref: DiffAvg: "43.09"
xref: DiffFormula: "C 3 H 7 N 0 O 0 S 0"
xref: DiffMono: "43.054227"
xref: FormalCharge: "1+"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue

[Term]
id: MOD:00712
name: methylated proline
def: "A protein modification that effectively converts an L-proline residue to a methylated proline, such as N,N-dimethylproline." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MePro" EXACT PSI-MOD-label []
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:00713
name: methylated glutamic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to a methylated glutamic acid, such as L-glutamate 5-methyl ester." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeGlu" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:00714
name: methylated glycine
def: "A protein modification that effectively converts a glycine residue to a methylated glycine, such as N-methylglycine." [PubMed:18688235]
synonym: "MeGly" EXACT PSI-MOD-label []
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00908 ! modified glycine residue

[Term]
id: MOD:00715
name: methylated isoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to a methylated isoleucine residue, such as N-methyl-L-isoleucine." [PubMed:18688235]
synonym: "MeIle" EXACT PSI-MOD-label []
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00910 ! modified L-isoleucine residue

[Term]
id: MOD:00716
name: methylated methionine
def: "A protein modification that effectively converts an L-methionine residue to a methylated methionine, such as N-methyl-L-methionine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeMet" EXACT PSI-MOD-label []
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:00717
name: methylated phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to a methylated phenylalanine, such as N-methyl-L-phenylalanine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MePhe" EXACT PSI-MOD-label []
xref: Origin: "F"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00914 ! modified L-phenylalanine residue

[Term]
id: MOD:00718
name: methylated tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to a methylated tyrosine, such as N-methyl-L-tyrosine." [PubMed:18688235]
synonym: "MeTyr" EXACT PSI-MOD-label []
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00719
name: L-methionine sulfoxide
def: "A protein modification that oxygenates an L-methionine residue to one of the diastereomeric L-methionine sulfoxide residues." [DeltaMass:177, OMSSA:1, PubMed:21406390, PubMed:22116028, RESID:AA0581, Unimod:35#M]
comment: From DeltaMass: Average Mass: 147 Formula:C5H9O1N2S Monoisotopic Mass Change:147.035 Average Mass Change:147.195 (formula incorrect, N and O reversed) References:PE Sciex.
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid" EXACT RESID-systematic []
synonym: "L-methionine (R)-S-oxide" EXACT RESID-alternate []
synonym: "L-methionine (R)-sulfoxide" EXACT RESID-name []
synonym: "L-methionine S-oxide" EXACT PSI-MOD-alternate []
synonym: "L-methionine sulfoxide" EXACT PSI-MOD-alternate []
synonym: "Methionyl Sulfoxide" EXACT DeltaMass-label []
synonym: "MetO" EXACT PSI-MOD-label []
synonym: "MOD_RES Methionine sulfoxide" EXACT UniProt-feature []
synonym: "Oxidation" RELATED PSI-MS-label []
synonym: "oxym" EXACT OMSSA-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 9 N 1 O 2 S 1"
xref: MassAvg: "147.19"
xref: MassMono: "147.035400"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:35"
xref: uniprot.ptm:PTM-0469
is_a: MOD:00709 ! sulfur oxygenated L-methionine
is_a: MOD:01854 ! sulfur monooxygenated residue

[Term]
id: MOD:00720
name: L-methionine (R)-sulfoxide
def: "A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide R-diastereomer." [ChEBI:45764, PubMed:21406390, PubMed:22116028, PubMed:23911929, RESID:AA0581]
synonym: "(2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid" EXACT RESID-systematic []
synonym: "L-methionine (R)-S-oxide" EXACT RESID-alternate []
synonym: "L-methionine (R)-sulfoxide" EXACT RESID-name []
synonym: "MOD_RES Methionine (R)-sulfoxide" EXACT UniProt-feature []
synonym: "R-MetO" EXACT PSI-MOD-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 9 N 1 O 2 S 1"
xref: MassAvg: "147.19"
xref: MassMono: "147.035400"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0480
is_a: MOD:00719 ! L-methionine sulfoxide

[Term]
id: MOD:00721
name: L-methionine (S)-sulfoxide
def: "A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide S-diastereomer." [PubMed:18688235]
synonym: "S-MetO" EXACT PSI-MOD-label []
synonym: "MOD_RES Methionine (S)-sulfoxide" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 9 N 1 O 2 S 1"
xref: MassAvg: "147.19"
xref: MassMono: "147.035400"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0481
is_a: MOD:00719 ! L-methionine sulfoxide

[Term]
id: MOD:00722
name: monomethylated L-glutamine
def: "A protein modification that effectively replaces one hydrogen atom of an L-glutamine residue with one methyl group." [OMSSA:14, Unimod:34#Q]
subset: PSI-MOD-slim
synonym: "Me1Gln" EXACT PSI-MOD-label []
synonym: "methylq" EXACT OMSSA-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 6 H 10 N 2 O 2"
xref: MassAvg: "142.16"
xref: MassMono: "142.074228"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00659 ! methylated glutamine

[Term]
id: MOD:00723
name: N-acetylated L-lysine
def: "A protein modification that effectively converts an L-lysine residue to either N2-acetyl-L-lysine, or N6-acetyl-L-lysine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "NAcLys" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 8 H 15 N 2 O 2"
xref: MassAvg: "171.22"
xref: MassMono: "171.113353"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00408 ! mono N-acetylated residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00724
name: N-methylated L-histidine
def: "A protein modification that effectively replaces one hydrogen atom on a nitrogen of an L-histidine residue with one methyl group." [OMSSA:74, Unimod:34#H]
subset: PSI-MOD-slim
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "methylh" EXACT OMSSA-label []
synonym: "NMeHis" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 9 N 3 O 1"
xref: MassAvg: "151.17"
xref: MassMono: "151.074562"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:00661 ! methylated histidine

[Term]
id: MOD:00725
name: complex glycosylation
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group linked through a glycosidic bond." [PubMed:18688235]
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00726
name: glucosylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a glucose group through a glycosidic bond." [PubMed:18688235]
synonym: "Glc" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:00433"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00727
name: mannosylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a mannose group through a glycosidic bond," [PubMed:18688235]
synonym: "Man" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00728
name: galactosylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a galactose group through a glycosidic bond." [PubMed:18688235]
synonym: "Gal" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00729
name: pentosylated residue
def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a pentose sugar group through a glycosidic bond" [DeltaMass:172]
comment: for Pentoses DeltaMass gives mass 132, for Pentosyl DeltaMass gives formula C 6 H 10 N4 with mass 146
synonym: "Pent" EXACT PSI-MOD-label []
synonym: "Pentoses (Ara, Rib, Xyl)" EXACT DeltaMass-label []
synonym: "Pentosyl" EXACT DeltaMass-label []
xref: DiffAvg: "132.12"
xref: DiffFormula: "C 5 H 8 O 4"
xref: DiffMono: "132.042259"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00730
name: arabinosylated residue
def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a arabinose sugar group through a glycosidic bond" [PubMed:18688235]
synonym: "Ara" EXACT PSI-MOD-label []
xref: DiffAvg: "132.12"
xref: DiffFormula: "C 5 H 8 O 4"
xref: DiffMono: "132.042259"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00729 ! pentosylated residue

[Term]
id: MOD:00731
name: ribosylated residue
def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a ribose sugar group through a glycosidic bond" [PubMed:18688235]
synonym: "Rib" EXACT PSI-MOD-label []
xref: DiffAvg: "132.12"
xref: DiffFormula: "C 5 H 8 O 4"
xref: DiffMono: "132.042259"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00729 ! pentosylated residue

[Term]
id: MOD:00732
name: xylosylated residue
def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a xylose sugar group through a glycosidic bond" [PubMed:18688235]
synonym: "Xyl" EXACT PSI-MOD-label []
xref: DiffAvg: "132.12"
xref: DiffFormula: "C 5 H 8 O 4"
xref: DiffMono: "132.042259"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00729 ! pentosylated residue

[Term]
id: MOD:00733
name: N-acetylaminoglucosylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylglucosamine group through a glycosidic bond." [PubMed:18688235]
synonym: "GlcNAc" EXACT PSI-MOD-label []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00436 ! N-acetylhexosaminylated residue

[Term]
id: MOD:00734
name: N-acetylaminogalactosylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylgalactosamine group through a glycosidic bond." [DeltaMass:247]
comment: From DeltaMass: Average Mass: 203 Formula:C8H13O5N1 Monoisotopic Mass Change:203.079 Average Mass Change:203.196 References:PE Sciex
synonym: "GalNAc" EXACT PSI-MOD-label []
synonym: "N-acetylhexosamines (GalNAc, GlcNAc)" EXACT DeltaMass-label []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00436 ! N-acetylhexosaminylated residue

[Term]
id: MOD:00735
name: hexosuronylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosuronic acid group through a glycosidic bond." [PubMed:18688235]
synonym: "HexA" EXACT PSI-MOD-label []
xref: DiffAvg: "176.12"
xref: DiffFormula: "C 6 H 8 O 6"
xref: DiffMono: "176.032088"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00736
name: deoxyhexosylated residue
def: "a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a deoxyhexose group through a glycosidic bond" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 146
subset: PSI-MOD-slim
synonym: "Deoxyhexoses (Fuc, Rha)" EXACT DeltaMass-label []
synonym: "dHex" EXACT PSI-MOD-label []
xref: DiffAvg: "146.14"
xref: DiffFormula: "C 6 H 10 O 4"
xref: DiffMono: "146.057909"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: GNOme: "GNO:G02438LG"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00737
name: N-acetylneuraminylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylneuraminic acid (sialic acid) group through a glycosidic bond." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 291
synonym: "N-acetylneuraminic acid (Sialic acid, NeuAc, NANA, SA)" EXACT DeltaMass-label []
synonym: "NeuNAc" EXACT PSI-MOD-label []
xref: DiffAvg: "291.26"
xref: DiffFormula: "C 11 H 17 N 1 O 8"
xref: DiffMono: "291.095417"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: GNOme: "GNO:G76685HR"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00738
name: iron containing modified residue
def: "A protein modification that effectively substitutes an iron atom or a cluster containing iron for hydrogen atoms, or that coordinates an iron ion." [PubMed:18688235]
synonym: "FeRes" EXACT PSI-MOD-label []
is_a: MOD:00698 ! metal or metal cluster containing modified residue

[Term]
id: MOD:00739
name: iron-sulfur cluster containing modification
def: "A protein modification that effectively substitutes a cluster of iron and sulfur atoms for hydrogen atoms." [PubMed:18688235]
synonym: "FeSRes" EXACT PSI-MOD-label []
is_a: MOD:00738 ! iron containing modified residue
is_a: MOD:00860 ! sulfur containing modified residue

[Term]
id: MOD:00740
name: manganese containing modified residue
def: "A protein modification that effectively substitutes a manganese atom or a cluster containing manganese for hydrogen atoms, or that coordinates a manganese ion." [PubMed:18688235]
synonym: "MnRes" EXACT PSI-MOD-label []
is_a: MOD:00698 ! metal or metal cluster containing modified residue

[Term]
id: MOD:00741
name: nickel containing modified residue
def: "A protein modification that effectively substitutes a nickel atom or a cluster containing nickel for hydrogen atoms, or that coordinates a nickel ion." [PubMed:18688235]
synonym: "NiRes" EXACT PSI-MOD-label []
is_a: MOD:00698 ! metal or metal cluster containing modified residue

[Term]
id: MOD:00742
name: copper containing modified residue
def: "A protein modification that effectively substitutes a copper atom or a cluster containing copper for hydrogen atoms, or that coordinates a copper ion." [PubMed:18688235]
synonym: "CuRes" EXACT PSI-MOD-label []
is_a: MOD:00698 ! metal or metal cluster containing modified residue

[Term]
id: MOD:00743
name: molybdenum containing modified residue
def: "A protein modification that effectively substitutes a molybdenum atom or a cluster containing molybdenum for hydrogen atoms, or that coordinates a molybdenum ion." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MoRes" EXACT PSI-MOD-label []
is_a: MOD:00698 ! metal or metal cluster containing modified residue

[Term]
id: MOD:00744
name: molybdenum pterin containing modification
def: "A protein modification containing a molybdenum atom in a pterin ring system." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MoPterRes" EXACT PSI-MOD-label []
is_a: MOD:00743 ! molybdenum containing modified residue
is_a: MOD:00748 ! pterin modified residue

[Term]
id: MOD:00745
name: selenium containing residue
def: "A protein modification that effectively substitutes a selenium atom or a cluster containing selenium for hydrogen atoms." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "SeRes" EXACT PSI-MOD-label []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00746
name: tungsten containing modified residue
def: "A protein modification that effectively substitutes a tungsten atom or a cluster containing tungsten for hydrogen atoms, or that coordinates a tungsten ion." [PubMed:18688235]
synonym: "WRes" EXACT PSI-MOD-label []
is_a: MOD:00698 ! metal or metal cluster containing modified residue

[Term]
id: MOD:00747
name: sodium containing modified residue
def: "A protein modification that effectively substitutes a sodium atom for a hydrogen atom." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "NaRes" EXACT PSI-MOD-label []
is_a: MOD:00698 ! metal or metal cluster containing modified residue

[Term]
id: MOD:00748
name: pterin modified residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a pterin group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "PterRes" EXACT PSI-MOD-label []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00749
name: sulfur substitution for oxygen
def: "A protein modification that effectively substitutes a sulfur atom for an oxygen atom." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "S(O)Res" EXACT PSI-MOD-label []
is_a: MOD:00860 ! sulfur containing modified residue

[Term]
id: MOD:00750
name: deoxyribonucleic acid linked residue
def: "A protein modification that effectively crosslinks an amino acid residue and the 3'- or 5'-end of DNA through a phosphodiester bond." [PubMed:18688235]
synonym: "DNARes" EXACT PSI-MOD-label []
is_a: MOD:00701 ! nucleotide or nucleic acid modified residue

[Term]
id: MOD:00751
name: ribonucleic acid linked residue
def: "a protein modification" [PubMed:18688235]
synonym: "RNARes" EXACT PSI-MOD-label []
is_a: MOD:00701 ! nucleotide or nucleic acid modified residue

[Term]
id: MOD:00752
name: monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue
def: "A protein modification that effectively results from forming an adduct with one ADP-ribose through formation of a glycosidic bond." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 541.
subset: PSI-MOD-slim
synonym: "ADP-rybosylation (from NAD)" EXACT DeltaMass-label []
synonym: "ADPRib1Res" EXACT PSI-MOD-label []
xref: DiffAvg: "541.30"
xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2"
xref: DiffMono: "541.061109"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02087 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue

[Term]
id: MOD:00753
name: chlorinated residue
def: "A protein modification that effectively substitutes a chlorine atom for a hydrogen atom." [PubMed:18688235]
synonym: "ClRes" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00694 ! halogen containing residue

[Term]
id: MOD:00754
name: brominated residue
def: "A protein modification that effectively substitutes a bromine atom for a hydrogen atom." [PubMed:18688235]
synonym: "BrRes" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00694 ! halogen containing residue

[Term]
id: MOD:00755
name: iodinated residue
def: "A protein modification that effectively substitutes an iodine atom of a residue for a hydrogen atom." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "IRes" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00694 ! halogen containing residue

[Term]
id: MOD:00756
name: 4-hydroxy-D-valine
def: "A protein modification that effectively converts an L-valine residue to 4-hydroxy-D-valine." [PubMed:15853325, RESID:AA0388]
synonym: "(2R,3Xi)-2-amino-4-hydroxy-3-methylbutanoic acid" EXACT RESID-systematic []
synonym: "4-hydroxy-D-valine" EXACT RESID-name []
synonym: "D-4HyVal" EXACT PSI-MOD-label []
synonym: "D-gamma-hydroxyvaline" EXACT RESID-alternate []
synonym: "MOD_RES D-4-hydroxyvaline" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 9 N 1 O 2"
xref: MassAvg: "115.13"
xref: MassMono: "115.063329"
xref: Origin: "V"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0111
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:00664 ! stereoisomerized residue

[Term]
id: MOD:00757
name: O4-galactosyl-L-hydroxyproline
def: "A protein modification that effectively converts an L-proline residue to O4-galactosyl-L-hydroxyproline." [RESID:AA0389]
comment: secondary to RESID:AA0030
synonym: "(2S,4R)-4-(beta-D-galactopyranosyloxy)pyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "4-(beta-D-galactopyranosyloxy)proline" EXACT RESID-alternate []
synonym: "4-(galactosyloxy)proline" EXACT RESID-alternate []
synonym: "beta-galactopyranosyl-4-hydroxyproline" EXACT RESID-alternate []
synonym: "O4-galactosyl-L-hydroxyproline" EXACT RESID-name []
synonym: "O4-glycosyl-hydroxyproline" EXACT RESID-alternate []
synonym: "CARBOHYD O-linked (Gal) hydroxyproline" EXACT UniProt-feature []
xref: DiffAvg: "178.14"
xref: DiffFormula: "C 6 H 10 N 0 O 6"
xref: DiffMono: "178.047738"
xref: Formula: "C 11 H 17 N 1 O 7"
xref: MassAvg: "275.26"
xref: MassMono: "275.100502"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0558
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:00758
name: O4-(N-acetylamino)glucosyl-L-hydroxyproline
def: "A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)glucosyl-L-hydroxyproline." [PubMed:15238247, PubMed:9660787, RESID:AA0390]
comment: secondary to RESID:AA0030
synonym: "(2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-glucopyranosyloxy]pyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "4-(N-acetylglucosaminyloxy)proline" EXACT RESID-alternate []
synonym: "4-[(2-N-acetylamino)-alpha-D-glucopyranosyl]oxyproline" EXACT RESID-alternate []
synonym: "alpha-2-(N-acetylamino)glucopyranosyl-4-hydroxyproline" EXACT RESID-alternate []
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "O4-(N-acetylamino)glucosyl-L-hydroxyproline" EXACT RESID-name []
synonym: "O4-glycosyl-hydroxyproline" EXACT RESID-alternate []
synonym: "O4GlcNAcHyPro" EXACT PSI-MOD-label []
synonym: "CARBOHYD O-linked (GlcNAc) hydroxyproline" EXACT UniProt-feature []
xref: DiffAvg: "219.19"
xref: DiffFormula: "C 8 H 13 N 1 O 6"
xref: DiffMono: "219.074287"
xref: Formula: "C 13 H 20 N 2 O 7"
xref: MassAvg: "316.31"
xref: MassMono: "316.127051"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0578
is_a: MOD:01677 ! O4-(N-acetylamino)hexosyl-L-hydroxyproline

[Term]
id: MOD:00759
name: fucosylated biantennary (-1 galactose) N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation" [Unimod:307]
synonym: "dHex(1)Hex(4)HexNAc(4)" RELATED PSI-MS-label []
synonym: "Fucosylated biantennary (-1 galactose)" RELATED Unimod-description []
xref: DiffAvg: "1607.48"
xref: DiffFormula: "C 62 H 102 N 4 O 44"
xref: DiffMono: "1606.586693"
xref: Formula: "C 66 H 108 N 6 O 46"
xref: MassAvg: "1721.59"
xref: MassMono: "1720.629620"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:307"
xref: GNOme: "GNO:G59937CP"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00760
name: biantennary N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation - missing ref" [Unimod:311]
synonym: "Biantennary" RELATED Unimod-description []
synonym: "Hex(5)HexNAc(4)" RELATED PSI-MS-label []
xref: DiffAvg: "1623.48"
xref: DiffFormula: "C 62 H 102 N 4 O 45"
xref: DiffMono: "1622.581607"
xref: Formula: "C 66 H 108 N 6 O 47"
xref: MassAvg: "1737.59"
xref: MassMono: "1736.624535"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:311"
xref: GNOme: "GNO:G10486CT"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00761
name: monohexosylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with one hexose sugar group through a glycosidic bond." [PubMed:18688235]
synonym: "Hex1" EXACT PSI-MOD-alternate []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: GNOme: "GNO:G81399MY"
is_a: MOD:00434 ! hexosylated residue

[Term]
id: MOD:00762
name: biantennary (-2 galactose) N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation - missing ref" [Unimod:309]
synonym: "Biantennary (-2 galactose)" RELATED Unimod-description []
synonym: "Hex(3)HexNAc(4)" RELATED PSI-MS-label []
xref: DiffAvg: "1299.20"
xref: DiffFormula: "C 50 H 82 N 4 O 35"
xref: DiffMono: "1298.475960"
xref: Formula: "C 54 H 88 N 6 O 37"
xref: MassAvg: "1413.30"
xref: MassMono: "1412.518888"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:309"
xref: GNOme: "GNO:G35029YA"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00763
name: biantennary (-1 galactose) N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation - missing ref" [Unimod:310]
synonym: "Biantennary (-1 galactose)" RELATED Unimod-description []
synonym: "Hex(4)HexNAc(4)" RELATED PSI-MS-label []
xref: DiffAvg: "1461.34"
xref: DiffFormula: "C 56 H 92 N 4 O 40"
xref: DiffMono: "1460.528784"
xref: Formula: "C 60 H 98 N 6 O 42"
xref: MassAvg: "1575.44"
xref: MassMono: "1574.571711"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:310"
xref: GNOme: "GNO:G72787SB"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:00764
name: glycoconjugated residue
def: "A protein modification that effectively results from forming an adduct with a carbohydrate-like group either through enzymatic formation of a glycosidic bond, or through non-enzymatic glycation formation of a Schiff-base or an Amadori ketosamine residue adduct." [PubMed:18688235, PubMed:3743566]
subset: PSI-MOD-slim
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00765
name: cysteinylation (disulfide with free L-cysteine)
def: "A protein modification that effectively converts an L-cysteine residue to S-(L-cysteinyl)-L-cysteine, forming a disulfide bond with free cysteine." [DeltaMass:260, PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, RESID:AA0025#CYS1, Unimod:312]
comment: This entry is for formation of a disulfide bond between a peptide cysteine and a free cysteine. For the cystine cross-link, see MOD:00234. From DeltaMass: (name misspelled and formula incorrect, N and O reversed) Formula: C6H10O2N3S2 Monoisotopic Mass Change: 222.013 Average Mass Change: 222.283
subset: PSI-MOD-slim
synonym: "(2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic []
synonym: "2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid" RELATED RESID-misnomer []
synonym: "3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid)" EXACT RESID-alternate []
synonym: "3,3'-dithiobis(2-aminopropanoic acid)" EXACT RESID-alternate []
synonym: "3,3'-dithiobisalanine" EXACT RESID-alternate []
synonym: "3,3'-dithiodialanine" EXACT RESID-alternate []
synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide" EXACT RESID-alternate []
synonym: "beta,beta'-dithiodialanine" EXACT RESID-alternate []
synonym: "bis(alpha-aminopropionic acid)-beta-disulfide" EXACT RESID-alternate []
synonym: "bis(beta-amino-beta-carboxyethyl)disulfide" EXACT RESID-alternate []
synonym: "Cysteinylation" EXACT DeltaMass-label []
synonym: "dicysteine" EXACT RESID-alternate []
synonym: "L-cystine" EXACT RESID-name []
synonym: "MOD_RES S-cysteinyl cysteine" EXACT UniProt-feature []
synonym: "S-cystenyl cystenyl" EXACT DeltaMass-label []
synonym: "SCysCys" EXACT PSI-MOD-label []
xref: DiffAvg: "119.14"
xref: DiffFormula: "C 3 H 5 N 1 O 2 S 1"
xref: DiffMono: "119.004099"
xref: Formula: "C 6 H 10 N 2 O 3 S 2"
xref: MassAvg: "222.28"
xref: MassMono: "222.013284"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:312"
xref: uniprot.ptm:PTM-0415
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01862 ! disulfide conjugated residue

[Term]
id: MOD:00766
name: C terminal -K from HC of MAb
def: "modification from Unimod Post-translational - C-terminal loss of lysine OBSOLETE because the idenical to MOD:01642. Remap to MOD:01642" [PubMed:16078144, Unimod:313]
synonym: "Loss of C-terminal K from Heavy Chain of MAb" RELATED Unimod-description []
synonym: "Lys-loss" RELATED PSI-MS-label []
xref: DiffAvg: "-128.18"
xref: DiffFormula: "C -6 H -12 N -2 O -1"
xref: DiffMono: "-128.094963"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:313"
xref: Remap: "MOD:01642"
is_obsolete: true

[Term]
id: MOD:00767
name: glycated residue
def: "A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein amino group to form a Schiff-base or an Amadori ketosamine residue adduct." [PubMed:18688235]
xref: Source: "artifact"
is_a: MOD:00764 ! glycoconjugated residue

[Term]
id: MOD:00768
name: methionine oxidation with neutral loss of 80 Da
def: "Oxidation of methionine to methionine sulfone with neutral loss of CH3SO2H." [PubMed:18688235, PubMed:9004526]
comment: Originally created from Unimod:508 that was later deleted.
xref: DiffAvg: "-80.10"
xref: DiffFormula: "C -1 H -4 N 0 O -2 S -1"
xref: DiffMono: "-79.993200"
xref: Formula: "C 4 H 5 N 1 O 1 S 0"
xref: MassAvg: "83.09"
xref: MassMono: "83.037114"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00431 ! modified residue with a secondary neutral loss

[Term]
id: MOD:00769
name: residues isobaric at 71.0-71.1 Da
def: "Natural or modified residues with a mass of 71.0-71.1 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da

[Term]
id: MOD:00770
name: residues isobaric at a resolution below 0.01 Da
def: "Natural or modified residues that are isobaric at a resolution below 0.01 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da

[Term]
id: MOD:00771
name: residues isobaric at 166.98-167.00 Da
def: "Natural or modified residues with a mass of 166.98-167.00 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da

[Term]
id: MOD:00772
name: vanadium containing modified residue
def: "A protein modification that effectively substitutes a vanadium atom or a cluster containing vanadium for hydrogen atoms, or that coordinates a vanadium ion." [PubMed:18688235]
synonym: "VRes" EXACT PSI-MOD-label []
is_a: MOD:00698 ! metal or metal cluster containing modified residue

[Term]
id: MOD:00773
name: residues isobaric at 181.00-181.02 Da
def: "Natural or modified residues with a mass of 181.00-181.02 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da

[Term]
id: MOD:00774
name: residues isobaric at 243.02-243.03 Da
def: "Natural or modified residues with a mass of 243.02-243.03 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da

[Term]
id: MOD:00775
name: L-asparagine (His)
def: "An artifactual protein modification that converts an L-histidine residue to L-asparagine by oxidative degradation." [OMSSA:54, PubMed:9252331, Unimod:348]
synonym: "His->Asn" RELATED PSI-MS-label []
synonym: "his2asnh" EXACT OMSSA-label []
synonym: "histidine oxidation to aspargine" RELATED Unimod-description []
xref: DiffAvg: "-23.04"
xref: DiffFormula: "C -2 H -1 N -1 O 1"
xref: DiffMono: "-23.015984"
xref: Formula: "C 4 H 6 N 2 O 2"
xref: MassAvg: "114.10"
xref: MassMono: "114.042927"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:348"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:02088 ! natural, standard, encoded residue substitution

[Term]
id: MOD:00776
name: L-aspartic acid (His)
def: "An artifactual protein modification that converts an L-histidine residue to L-aspartic acid by oxidative degradation." [OMSSA:55, PubMed:9252331, Unimod:349]
comment: From OMSSA: desc="oxidation of H to D" monomass= -23.015984 (this is the same mass difference as OMSSA:54, his2asnh) [JSG].
synonym: "His->Asp" RELATED PSI-MS-label []
synonym: "his2asph" EXACT OMSSA-label []
synonym: "histidine oxidation to aspartic acid" RELATED Unimod-description []
xref: DiffAvg: "-22.05"
xref: DiffFormula: "C -2 H -2 N -2 O 2"
xref: DiffMono: "-22.031969"
xref: Formula: "C 4 H 5 N 1 O 3"
xref: MassAvg: "115.09"
xref: MassMono: "115.026943"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:349"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:02088 ! natural, standard, encoded residue substitution

[Term]
id: MOD:00777
name: residues isobaric at 182.96-182.98 Da
def: "Natural or modified residues with a mass of 182.96-182.98 Da." [PubMed:18688235]
is_a: MOD:00770 ! residues isobaric at a resolution below 0.01 Da
is_a: MOD:00778 ! residues isobaric at 182.9-183.0 Da

[Term]
id: MOD:00778
name: residues isobaric at 182.9-183.0 Da
def: "Natural or modified residues with a mass of 182.9-183.0 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da

[Term]
id: MOD:00779
name: lysine oxidation to aminoadipic semialdehyde
def: "OBSOLETE because redundant with MOD:00130. Remap to MOD:00130." [DeltaMass:352, PubMed:11332453, PubMed:358196, PubMed:5337886, PubMed:5529814, Unimod:352]
comment: From DeltaMass: Average Mass: -1 Average Mass Change:-1 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001.
synonym: "Oxidation of lysine (to aminoadipic semialdehyde)" EXACT DeltaMass-label []
xref: DiffAvg: "-1.03"
xref: DiffFormula: "H -3 N -1 O 1"
xref: DiffMono: "-1.031634"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:00130"
xref: Unimod: "Unimod:352"
is_obsolete: true

[Term]
id: MOD:00780
name: N-acetyl-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to N-acetyl-L-asparagine." [PubMed:18688235]
comment: This modification has not been observed to occur naturally.
synonym: "AcAsn" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 6 H 8 N 2 O 3"
xref: MassAvg: "156.14"
xref: MassMono: "156.053492"
xref: Origin: "N"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00903 ! modified L-asparagine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00781
name: N2-acetyl-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to N2-acetyl-L-histidine." [PubMed:18688235]
comment: This modification has not been observed to occur naturally.
synonym: "AcHis" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 8 H 9 N 3 O 2"
xref: MassAvg: "179.18"
xref: MassMono: "179.069477"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00782
name: N-acetyl-L-leucine
def: "A protein modification that effectively converts an L-leucine residue to N-acetyl-L-leucine." [PubMed:18688235]
comment: This modification has not been observed to occur naturally.
synonym: "AcLeu" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 8 H 14 N 1 O 2"
xref: MassAvg: "156.20"
xref: MassMono: "156.102454"
xref: Origin: "L"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00911 ! modified L-leucine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00783
name: dimethylated L-arginine
def: "A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two methyl groups." [OMSSA:37, Unimod:36#R]
subset: PSI-MOD-slim
synonym: "Dimethyl" RELATED PSI-MS-label []
synonym: "dimethylr" EXACT OMSSA-label []
synonym: "NNMe2Arg" EXACT PSI-MOD-label []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4 N 0 O 0"
xref: DiffMono: "28.031300"
xref: Formula: "C 8 H 16 N 4 O 1"
xref: MassAvg: "184.24"
xref: MassMono: "184.132411"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:36"
xref: uniprot.ptm:PTM-0341
is_a: MOD:00429 ! dimethylated residue
is_a: MOD:00658 ! methylated arginine

[Term]
id: MOD:00784
name: N-acetyl-L-phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to N-acetyl-L-phenylalanine." [PubMed:18688235]
comment: This modification has not been observed to occur naturally.
synonym: "AcPhe" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 11 H 11 N 1 O 2"
xref: MassAvg: "189.21"
xref: MassMono: "189.078979"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00914 ! modified L-phenylalanine residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00785
name: N2-acetyl-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to N2-acetyl-L-tryptophan." [PubMed:18688235]
comment: This modification has not been observed to occur naturally.
synonym: "AcTrp" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 13 H 12 N 2 O 2"
xref: MassAvg: "228.25"
xref: MassMono: "228.089878"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00918 ! modified L-tryptophan residue
is_a: MOD:01458 ! alpha-amino acetylated residue

[Term]
id: MOD:00786
name: deuterium substituted residue
def: "A protein modification that effectively substitutes one or more (2)H deuterium atoms for (1)H protium atoms." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "D(H)Res" EXACT PSI-MOD-label []
is_a: MOD:00839 ! (2)H deuterium labeled residue

[Term]
id: MOD:00787
name: diisopropylphosphoserine
def: "modification from Unimod - label for the active site serine of the serine esterase/protease family also shown to label tyrosine in serum albumin" [Unimod:362]
synonym: "Diisopropylphosphate" RELATED Unimod-interim []
synonym: "O-Diisopropylphosphorylation" RELATED Unimod-description []
xref: DiffAvg: "164.14"
xref: DiffFormula: "C 6 H 13 O 3 P 1"
xref: DiffMono: "164.060231"
xref: Formula: "C 9 H 18 N 1 O 5 P 1"
xref: MassAvg: "251.22"
xref: MassMono: "251.092259"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:362"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00788
name: isopropylphosphotyrosine
def: "modification from Unimod" [Unimod:363]
synonym: "Isopropylphospho" RELATED Unimod-interim []
synonym: "O-Isopropylphosphorylation" RELATED Unimod-description []
xref: DiffAvg: "122.06"
xref: DiffFormula: "C 3 H 7 O 3 P 1"
xref: DiffMono: "122.013281"
xref: Formula: "C 12 H 16 N 1 O 5 P 1"
xref: MassAvg: "285.24"
xref: MassMono: "285.076609"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:363"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00789
name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form
def: "modification from Unimod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied." [PubMed:15602776, Unimod:364, URL:http\://www.serva.de/products/sheets/39230-E.pdf]
synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form" RELATED Unimod-description []
synonym: "ICPL:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "111.04"
xref: DiffFormula: "(13)C 6 H 3 N 1 O 1"
xref: DiffMono: "111.041593"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:364"
is_a: MOD:01428 ! (13)C isotope tagged reagent

[Term]
id: MOD:00790
name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form
def: "modification from Unimod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied." [PubMed:15602776, Unimod:365, URL:http\://www.serva.de/products/sheets/39230-E.pdf]
synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form" RELATED Unimod-description []
synonym: "ICPL" RELATED PSI-MS-label []
xref: DiffAvg: "105.02"
xref: DiffFormula: "(12)C 6 H 3 N 1 O 1"
xref: DiffMono: "105.021464"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:365"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:00791
name: 1x(18)O labeled deamidated L-glutamine
def: "A protein modification that effectively converts an L-glutamine residue to L-glutamic acid with one (18)O." [PubMed:8382902, Unimod:366#Q]
subset: PSI-MOD-slim
synonym: "Deamidated:18O(1)" RELATED PSI-MS-label []
synonym: "Deamidation in presence of O18" RELATED Unimod-description []
xref: DiffAvg: "2.99"
xref: DiffFormula: "H -1 N -1 (18)O 1"
xref: DiffMono: "2.988262"
xref: Formula: "C 5 H 7 N 1 (16)O 2 (18)O 1"
xref: MassAvg: "131.05"
xref: MassMono: "131.046839"
xref: Origin: "Q"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:366"
relationship: derives_from MOD:00685 ! deamidated L-glutamine
is_a: MOD:00852 ! 1x(18)O labeled deamidated residue

[Term]
id: MOD:00792
name: deuterium monosubstituted residue
def: "A protein modification that effectively substitutes one (2)H deuterium atom for one (1)H protium atom." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "D(H)1Res" EXACT PSI-MOD-label []
is_a: MOD:00786 ! deuterium substituted residue

[Term]
id: MOD:00793
name: dehydroalanine (Cys)
def: "A protein modification that effectively converts an L-cysteine residue to dehydroalanine." [ChEBI:17123, DeltaMass:8, PubMed:10220322, PubMed:11212008, PubMed:1547888, PubMed:15799070, PubMed:1815586, PubMed:20805503, PubMed:2914619, PubMed:7947813, PubMed:8239649, RESID:AA0181#CYS, Unimod:368]
comment: From DeltaMass: In an attempt to clarfiy the difference between the modification of cysteine to lanthionine and cysteine to dehydroalanine, the following contributions from the ABRF email forum are presented:Structurally speaking lanthionine is like cystine but lacks one S atom. I imagine one can think of it as a condensation of cysteine and dehydroalanine but I do not know how it is made biologically. Dehydroalanine could be derived from either serine or cysteine. If I recall Biochem 101 correctly lanthionine was first found in wool.-Lowell Ericsson (ERICSSONLH@U.WASHINGTON.EDU)As far as I know, the structure of lanthionine is two Ala's joined by a single sulphur with the loss of two hydrogens from the methyl group of the Ala.Stephen Bayne (sbay@novo.dk)Regarding the structure of lanthionine and dehydroalanine: dehydroalanine is formed by the loss of one sulfur atom and two hydrogen atoms from ONE cysteine residue. lanthionine is formed from TWO cysteines, is a thioether, and contains one sulfur atom less than the amino acid cystine. Dan McCormick (MCCORMICK@rcf.mayo.edu) [DeltaMass]. Most bacterially produced lanthionine crosslinks are made by dehydration of L-serine to dehydroalanine, and then reaction with L-cysteine so as to produce chiral inversion at the alpha-carbon of the original L-serine; the lanthionine is a meso-diastereomer with L-configuration of the original cysteine alpha-carbon and D-configuration of the original L-serine alpha-carbon. In cypemycin dehydroalanine has been shown to be produced by loss of hydrogen sulfide from cysteine. Beta-elimination of hydrogen sulfide does occur during treatment with performic acid [JSG].
subset: PSI-MOD-slim
synonym: "2,3-didehydroalanine" EXACT RESID-alternate []
synonym: "2-aminoacrylic acid" EXACT RESID-alternate []
synonym: "2-aminopropenoic acid" EXACT RESID-systematic []
synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate []
synonym: "anhydroserine" EXACT RESID-alternate []
synonym: "Cys->Dha" RELATED PSI-MS-label []
synonym: "dehydroalanine" EXACT RESID-name []
synonym: "Dehydroalanine (from Cysteine)" EXACT DeltaMass-label []
synonym: "Dehydroalanine (from Cysteine)" RELATED Unimod-description []
synonym: "Dha" EXACT RESID-alternate []
synonym: "dHAla(Cys)" EXACT PSI-MOD-label []
synonym: "MOD_RES 2,3-didehydroalanine (Cys)" EXACT UniProt-feature []
xref: DiffAvg: "-34.08"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1"
xref: DiffMono: "-33.987721"
xref: Formula: "C 3 H 3 N 1 O 1"
xref: MassAvg: "69.06"
xref: MassMono: "69.021464"
xref: Origin: "C"
xref: Source: "natural"
xref: Unimod: "Unimod:368"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0468
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01168 ! dehydroalanine

[Term]
id: MOD:00794
name: pyrrolidone from proline
def: "OBSOLETE because redundant and identical to MOD:00477. Remap to MOD:00477." [PubMed:9252331, Unimod:369]
comment: This Unimod entry appears to have come from the same description in PubMed:9252331 as Unimod:360. This entry was not annotated as being approved. Neither difference formula corresponds to the result described in the original citation PubMed:2161657.
synonym: "Pro->Pyrrolidone" RELATED Unimod-interim []
synonym: "Pyrrolidone from Proline" RELATED Unimod-description []
xref: DiffAvg: "-28.01"
xref: DiffFormula: "C -1 O -1"
xref: DiffMono: "-27.994915"
xref: Formula: "C 4 H 7 N 1 O 0"
xref: MassAvg: "69.11"
xref: MassMono: "69.057849"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00477"
xref: Unimod: "Unimod:369"
is_obsolete: true

[Term]
id: MOD:00795
name: Michael addition of hydroxymethylvinyl ketone to cysteine
def: "modification from Unimod" [PubMed:11743741, Unimod:371]
synonym: "HMVK" RELATED PSI-MS-label []
synonym: "Michael addition of hydroxymethylvinyl ketone to cysteine" RELATED Unimod-description []
xref: DiffAvg: "86.09"
xref: DiffFormula: "C 4 H 6 O 2"
xref: DiffMono: "86.036779"
xref: Formula: "C 7 H 11 N 1 O 3 S 1"
xref: MassAvg: "189.23"
xref: MassMono: "189.045964"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:371"
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00796
name: L-ornithine (Arg)
def: "A protein modification that effectively converts an L-arginine residue to L-ornithine." [DeltaMass:129, OMSSA:163, PubMed:15489230, Unimod:372]
subset: PSI-MOD-slim
synonym: "Arg->Orn" RELATED PSI-MS-label []
synonym: "arg2orn" EXACT OMSSA-label []
synonym: "Ornithine (from Arginine)" EXACT DeltaMass-label []
synonym: "Ornithine from Arginine" RELATED Unimod-description []
synonym: "Ornithyl" EXACT DeltaMass-label []
xref: DiffAvg: "-42.04"
xref: DiffFormula: "C -1 H -2 N -2"
xref: DiffMono: "-42.021798"
xref: Formula: "C 5 H 10 N 2 O 1"
xref: MassAvg: "114.15"
xref: MassMono: "114.079313"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:372"
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00797
name: 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal
def: "a protein modification that effectively converts an L-cysteine residue to the PEP adduct, 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal" [PubMed:4696757, PubMed:7999765, PubMed:8664284, RESID:AA0391, ChEBI:149496]
synonym: "(2R)-2-amino-3-[1-carboxy-1-(phosphonooxy)ethyl]sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid" EXACT RESID-alternate []
synonym: "2-([(2R)-2-azanyl-2-carboxyethyl]sulfanyl)-2-(phosphonooxy)propanoic acid" EXACT RESID-alternate []
synonym: "2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal" EXACT RESID-name []
synonym: "cysteinyl pyruvate O-phosphothioketal" EXACT RESID-alternate []
synonym: "MOD_RES 2-(S-cysteinyl)pyruvic acid O-phosphothioketal" EXACT UniProt-feature []
synonym: "phosphoenolpyruvate cysteine adduct" EXACT RESID-alternate []
synonym: "phospholactoyl cysteine adduct" EXACT RESID-alternate []
synonym: "S-[1-carboxy-1-(phosphonooxy)ethyl]cysteine" EXACT RESID-alternate []
synonym: "SPEPCys" EXACT PSI-MOD-label []
xref: DiffAvg: "168.04"
xref: DiffFormula: "C 3 H 5 N 0 O 6 P 1 S 0"
xref: DiffMono: "167.982375"
xref: Formula: "C 6 H 10 N 1 O 7 P 1 S 1"
xref: MassAvg: "271.18"
xref: MassMono: "270.991559"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0424
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00798
name: half cystine
def: "A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed." [PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, Unimod:374]
synonym: "Dehydro" RELATED PSI-MS-label []
synonym: "Half of a disulfide bridge" RELATED Unimod-description []
xref: DiffAvg: "-1.01"
xref: DiffFormula: "C 0 H -1 N 0 O 0 S 0"
xref: DiffMono: "-1.007825"
xref: Formula: "C 3 H 4 N 1 O 1 S 1"
xref: MassAvg: "102.13"
xref: MassMono: "102.001360"
xref: Origin: "C"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:374"
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00799
name: S-galactosyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-galactosyl-L-cysteine." [PubMed:11945907, RESID:AA0392]
comment: The reported peptide has not been isolated or characterized in subsequent work, and the peptide sequence has not been found in the human proteome. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "(2R)-2-amino-3-(D-galactopyranosylsulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "S-(beta-D-galactopyranosyl)cysteine" EXACT RESID-alternate []
synonym: "S-galactosyl-L-cysteine" EXACT RESID-name []
synonym: "S-glycosyl-cysteine" EXACT RESID-alternate []
synonym: "SGalCys" EXACT PSI-MOD-label []
synonym: "CARBOHYD S-linked (Gal) cysteine" EXACT UniProt-feature []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5 S 0"
xref: DiffMono: "162.052823"
xref: Formula: "C 9 H 15 N 1 O 6 S 1"
xref: MassAvg: "265.28"
xref: MassMono: "265.062008"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0624
is_a: MOD:00426 ! S-glycosylated residue
is_a: MOD:00476 ! monogalactosylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00800
name: L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide
def: "A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-vanadium seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide." [PubMed:2345152, RESID:AA0393]
comment: Cross-link 2; incidental to RESID:AA0300.
synonym: "CysHis-[V7Fe9S]" EXACT PSI-MOD-label []
synonym: "L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide carbide" EXACT RESID-name []
synonym: "nitrogenase iron-vanadium cofactor" EXACT RESID-alternate []
xref: DiffAvg: "932.51"
xref: DiffFormula: "C 7 Fe 7 H 6 N 0 O 7 S 9 V 1"
xref: DiffMono: "932.248513"
xref: Formula: "C 16 Fe 7 H 18 N 4 O 9 S 10 V 1"
xref: MassAvg: "1172.80"
xref: MassMono: "1172.316610"
xref: Origin: "C, H"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:00772 ! vanadium containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00801
name: L-cysteinyl-L-histidino-homocitryl octairon nonasulfide
def: "A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and an eight-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl octairon nonasulfide." [PubMed:8392330, RESID:AA0394]
comment: Cross-link 2; incidental to RESID:AA0300.
synonym: "CysHis-[8Fe9S]" EXACT PSI-MOD-label []
synonym: "L-cysteinyl-L-histidino-homocitryl octairon nonasulfide carbide" EXACT RESID-name []
synonym: "nitrogenase iron-iron cofactor" EXACT RESID-alternate []
xref: DiffAvg: "937.42"
xref: DiffFormula: "C 7 Fe 8 H 6 N 0 O 7 S 9"
xref: DiffMono: "937.240588"
xref: FormalCharge: "2-"
xref: Formula: "C 16 Fe 8 H 18 N 4 O 9 S 10"
xref: MassAvg: "1177.70"
xref: MassMono: "1177.308685"
xref: Origin: "C, H"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00802
name: L-histidino vanadium tetraoxide
def: "a protein modification that effectively converts an L-histidine residue to L-histidino vanadium tetraoxide" [PubMed:10543953, PubMed:16494433, PubMed:8552646, RESID:AA0395]
synonym: "(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (dihydroxy)dioxovanadium" EXACT RESID-alternate []
synonym: "1'-vanadato-L-histidine" EXACT RESID-alternate []
synonym: "bromoperoxidase vanadium cofactor" EXACT RESID-alternate []
synonym: "chloroperoxidase vanadium cofactor" EXACT RESID-alternate []
synonym: "dihydrogen (4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl) (tetraoxido)vanadate" EXACT RESID-systematic []
synonym: "haloperoxidase vanadium cofactor" EXACT RESID-alternate []
synonym: "histidine-1-vanadate" EXACT RESID-alternate []
synonym: "histidine-N(epsilon)-vanadate" EXACT RESID-alternate []
synonym: "histidine-N1'-vanadate" EXACT RESID-alternate []
synonym: "L-histidino vanadium tetraoxide" EXACT RESID-name []
synonym: "N(tau)-vanadatohistidine" EXACT RESID-alternate []
synonym: "NtauH2VO4His" EXACT PSI-MOD-label []
synonym: "tele-vanadatohistidine" EXACT RESID-alternate []
xref: DiffAvg: "116.95"
xref: DiffFormula: "C 0 H 2 N 0 O 4 V 1"
xref: DiffMono: "116.939268"
xref: Formula: "C 6 H 9 N 3 O 5 V 1"
xref: MassAvg: "254.10"
xref: MassMono: "253.998180"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00772 ! vanadium containing modified residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00803
name: 3-(S-L-cysteinyl)-L-tyrosine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 3-(S-L-cysteinyl)-L-tyrosine." [PubMed:15342250, RESID:AA0396]
comment: Cross-link 2.
synonym: "(2S,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(2-amino-2-carboxyethylthio)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-alternate []
synonym: "3-(L-cystein-S-yl)-L-tyrosine" EXACT RESID-name []
synonym: "CROSSLNK 3-(S-cysteinyl)-tyrosine (Cys-Tyr)" EXACT UniProt-feature []
synonym: "S-(tyros-3'-yl)cysteine" EXACT RESID-alternate []
synonym: "XLNKSCys3Tyr" EXACT PSI-MOD-label []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 12 H 12 N 2 O 3 S 1"
xref: MassAvg: "264.30"
xref: MassMono: "264.056863"
xref: Origin: "C, Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0020
is_a: MOD:02058 ! crosslinked L-tyrosine residue
is_a: MOD:01993 ! beta-carbon thioether crosslinked residues

[Term]
id: MOD:00804
name: O-glucosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine." [PubMed:10734111, PubMed:2105311, PubMed:2511201, RESID:AA0397]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(beta-D-glucopyranosyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (Glc) serine" EXACT UniProt-feature []
synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature []
synonym: "O-glucosyl-L-serine" EXACT RESID-name []
synonym: "O-glycosylserine" EXACT RESID-alternate []
synonym: "O3-glucosylserine" EXACT RESID-alternate []
synonym: "OGlcSer" EXACT PSI-MOD-label []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 9 H 15 N 1 O 7"
xref: MassAvg: "249.22"
xref: MassMono: "249.084852"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0573
is_a: MOD:00002 ! O-glycosyl-L-serine
is_a: MOD:00433 ! monoglucosylated residue

[Term]
id: MOD:00805
name: O-(N-acetylamino)glucosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminoglucosyl)-L-serine." [PubMed:3086323, PubMed:8404891, RESID:AA0398]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (GlcNAc) serine" EXACT UniProt-feature []
synonym: "CARBOHYD O-linked (HexNAc)" EXACT UniProt-feature []
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate []
synonym: "O-(N-acetylamino)glucosyl-L-serine" EXACT RESID-name []
synonym: "O-(N-acetylglucosaminyl)serine" EXACT RESID-alternate []
synonym: "O-glycosylserine" EXACT RESID-alternate []
synonym: "O-seryl-beta-N-acetylglucosaminide" EXACT RESID-alternate []
synonym: "O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate []
synonym: "O3-(N-acetylglucosaminyl)serine" EXACT RESID-alternate []
synonym: "OGlcNAcSer" EXACT PSI-MOD-label []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "C 11 H 18 N 2 O 7"
xref: MassAvg: "290.27"
xref: MassMono: "290.111401"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0580
is_a: MOD:00448 ! mono-N-acetylaminoglucosylated residue
is_a: MOD:01675 ! O-(N-acetylamino)hexosyl-L-serine

[Term]
id: MOD:00806
name: O-(N-acetylamino)glucosyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminoglucosyl)-L-threonine." [PubMed:3086323, PubMed:8404891, RESID:AA0399]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosyloxy)butanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (GlcNAc) threonine" EXACT UniProt-feature []
synonym: "CARBOHYD O-linked (HexNAc)" EXACT UniProt-feature []
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-L-threonine" EXACT RESID-alternate []
synonym: "O-(N-acetylamino)glucosyl-L-threonine" EXACT RESID-name []
synonym: "O-(N-acetylglucosaminyl)-L-threonine" EXACT RESID-alternate []
synonym: "O-glycosylthreonine" EXACT RESID-alternate []
synonym: "O-threonyl-beta-N-acetylglucosaminide" EXACT RESID-alternate []
synonym: "O3-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-threonine" EXACT RESID-alternate []
synonym: "O3-(N-acetylglucosaminyl)threonine" EXACT RESID-alternate []
synonym: "OGlcNAcThr" EXACT PSI-MOD-label []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "C 12 H 20 N 2 O 7"
xref: MassAvg: "304.30"
xref: MassMono: "304.127051"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0582
is_a: MOD:00448 ! mono-N-acetylaminoglucosylated residue
is_a: MOD:01676 ! O-(N-acetylamino)hexosyl-L-threonine

[Term]
id: MOD:00807
name: pyruvic acid (Ser)
def: "A protein modification that effectively converts an L-serine residue to pyruvic acid." [DeltaMass:23, PubMed:10085076, PubMed:3042771, PubMed:8464063, RESID:AA0127#SER, Unimod:385#S]
comment: DeltaMass gives mass 70 and difference mass -16 with no formula
subset: PSI-MOD-slim
synonym: "2-oxopropanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES Pyruvic acid (Ser)" EXACT UniProt-feature []
synonym: "Pyruvate" EXACT DeltaMass-label []
synonym: "pyruvic acid" EXACT RESID-name []
synonym: "Pyruvoyl- (Serine)" EXACT DeltaMass-label []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 3 H 3 O 2"
xref: MassAvg: "71.06"
xref: MassMono: "71.013304"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:385"
xref: uniprot.ptm:PTM-0266
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01154 ! pyruvic acid
is_a: MOD:01160 ! deaminated residue

[Term]
id: MOD:00808
name: O-galactosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O3-galactosylserine." [PubMed:666730, RESID:AA0400]
synonym: "(2S)-2-amino-3-(alpha-D-galactopyranosyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (Gal) serine" EXACT UniProt-feature []
synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature []
synonym: "O-galactosyl-L-serine" EXACT RESID-name []
synonym: "O-glycosylserine" EXACT RESID-alternate []
synonym: "O3-galactosylserine" EXACT RESID-alternate []
synonym: "OGalSer" EXACT PSI-MOD-label []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 9 H 15 N 1 O 7"
xref: MassAvg: "249.22"
xref: MassMono: "249.084852"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0560
is_a: MOD:00002 ! O-glycosyl-L-serine
is_a: MOD:00476 ! monogalactosylated residue

[Term]
id: MOD:00809
name: O-galactosyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O3-galactosylthreonine." [PubMed:2673008, RESID:AA0401]
synonym: "(2S,3R)-2-amino-3-(alpha-D-galactopyranosyloxy)butanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (Gal) threonine" EXACT UniProt-feature []
synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature []
synonym: "O-galactosyl-L-threonine" EXACT RESID-name []
synonym: "O-glycosylthreonine" EXACT RESID-alternate []
synonym: "O3-galactosylthreonine" EXACT RESID-alternate []
synonym: "OGalThr" EXACT PSI-MOD-label []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 10 H 17 N 1 O 7"
xref: MassAvg: "263.25"
xref: MassMono: "263.100502"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0562
is_a: MOD:00476 ! monogalactosylated residue
is_a: MOD:01348 ! O-hexosylated threonine

[Term]
id: MOD:00810
name: O-mannosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O3-mannosylserine." [PubMed:391559, RESID:AA0402]
synonym: "(2S)-2-amino-3-(alpha-D-mannopyranosyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature []
synonym: "CARBOHYD O-linked (Man) serine" EXACT UniProt-feature []
synonym: "O-glycosylserine" EXACT RESID-alternate []
synonym: "O-mannopyranosylserine" EXACT RESID-alternate []
synonym: "O-mannosyl-L-serine" EXACT RESID-name []
synonym: "O3-mannosylserine" EXACT RESID-alternate []
synonym: "OManSer" EXACT PSI-MOD-label []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 9 H 15 N 1 O 7"
xref: MassAvg: "249.22"
xref: MassMono: "249.084852"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0588
is_a: MOD:00002 ! O-glycosyl-L-serine
is_a: MOD:00595 ! monomannosylated residue

[Term]
id: MOD:00811
name: O-mannosyl-L-threonine
def: "a protein modification that effectively forms a O3-mannosylthreonine" [PubMed:391559, RESID:AA0403]
synonym: "(2S,3R)-2-amino-3-(alpha-D-mannopyranosyloxy)butanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (Hex)" EXACT UniProt-feature []
synonym: "CARBOHYD O-linked (Man) threonine" EXACT UniProt-feature []
synonym: "O-glycosylthreonine" EXACT RESID-alternate []
synonym: "O-mannosyl-L-threonine" EXACT RESID-name []
synonym: "O3-mannosylthreonine" EXACT RESID-alternate []
synonym: "OManThr" EXACT PSI-MOD-label []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 10 H 17 N 1 O 7"
xref: MassAvg: "263.25"
xref: MassMono: "263.100502"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0591
is_a: MOD:00595 ! monomannosylated residue
is_a: MOD:01348 ! O-hexosylated threonine

[Term]
id: MOD:00812
name: O-fucosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to an O-fucosylserine." [PubMed:10734111, PubMed:11067851, PubMed:11344537, PubMed:12096136, PubMed:1517205, PubMed:15189151, PubMed:1904059, PubMed:3311742, PubMed:3578767, RESID:AA0404, Unimod:295#S]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (dHex)" EXACT UniProt-feature []
synonym: "CARBOHYD O-linked (Fuc)" EXACT UniProt-feature []
synonym: "dHex" RELATED PSI-MS-label []
synonym: "Fucose" RELATED Unimod-description []
synonym: "O-fucosyl-L-serine" EXACT RESID-name []
synonym: "O-glycosylserine" EXACT RESID-alternate []
synonym: "O3-fucosylserine" EXACT RESID-alternate []
synonym: "OFucSer" EXACT PSI-MOD-label []
synonym: "CARBOHYD O-linked (Fuc) serine" EXACT UniProt-feature []
xref: DiffAvg: "146.14"
xref: DiffFormula: "C 6 H 10 N 0 O 4"
xref: DiffMono: "146.057909"
xref: Formula: "C 9 H 15 N 1 O 6"
xref: MassAvg: "233.22"
xref: MassMono: "233.089937"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:295"
xref: uniprot.ptm:PTM-0550
is_a: MOD:00002 ! O-glycosyl-L-serine
is_a: MOD:00614 ! fucosylated residue

[Term]
id: MOD:00813
name: O-fucosyl-L-threonine
def: "A protein modification that effectively converts an threonine residue to an O-fucosylthreonine." [PubMed:11344537, PubMed:11857757, PubMed:15189151, PubMed:1740125, PubMed:1900431, RESID:AA0405, Unimod:295#T]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-(6-deoxy-alpha-D-galactopyranosyloxy)butanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (dHex)" EXACT UniProt-feature []
synonym: "CARBOHYD O-linked (Fuc) threonine" EXACT UniProt-feature []
synonym: "dHex" RELATED PSI-MS-label []
synonym: "Fucose" RELATED Unimod-description []
synonym: "O-fucosyl-L-threonine" EXACT RESID-name []
synonym: "O-glycosylthreonine" EXACT RESID-alternate []
synonym: "O3-fucosylthreonine" EXACT RESID-alternate []
synonym: "OFucThr" EXACT PSI-MOD-label []
xref: DiffAvg: "146.14"
xref: DiffFormula: "C 6 H 10 N 0 O 4"
xref: DiffMono: "146.057909"
xref: Formula: "C 10 H 17 N 1 O 6"
xref: MassAvg: "247.25"
xref: MassMono: "247.105587"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:295"
xref: uniprot.ptm:PTM-0552
is_a: MOD:00005 ! O-glycosyl-L-threonine
is_a: MOD:00614 ! fucosylated residue

[Term]
id: MOD:00814
name: O-xylosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O3-xylosylserine." [PubMed:8747463, RESID:AA0406]
comment: One glycosylated serine with weak electron density was modeled as O3-alpha-xylosylserine, while O3-alpha-mannosyl serine and threonine were modeled at ten other positions. The authors do not discuss this exception or provide chemical evidence for it. Since an O3-xylosyl serine modification has not been reported in any other fungal proteins, the modification is probably also an O3-alpha-mannosyl serine, see MOD:00810 [JSG].
synonym: "(2S)-2-amino-3-(alpha-D-xylopyranosyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "O-(beta-D-xylopyranosyl)-L-serine" EXACT RESID-alternate []
synonym: "O-glycosylserine" EXACT RESID-alternate []
synonym: "O-xylosyl-L-serine" EXACT RESID-name []
synonym: "O3-xylosylserine" EXACT RESID-alternate []
synonym: "OXylSer" EXACT PSI-MOD-label []
synonym: "CARBOHYD O-linked (Xyl) serine" EXACT UniProt-feature []
xref: DiffAvg: "132.12"
xref: DiffFormula: "C 5 H 8 N 0 O 4"
xref: DiffMono: "132.042259"
xref: Formula: "C 8 H 13 N 1 O 6"
xref: MassAvg: "219.19"
xref: MassMono: "219.074287"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0598
is_a: MOD:00002 ! O-glycosyl-L-serine

[Term]
id: MOD:00815
name: molybdopterin
def: "OBSOLETE because redundant with MOD:00151. Remap to MOD:00151." [PubMed:14527393, PubMed:7878465, PubMed:9428520]
xref: DiffAvg: "520.27"
xref: DiffFormula: "C 10 H 11 Mo 1 N 5 O 8 P 1 S 2"
xref: DiffMono: "521.884074"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:00151"
is_obsolete: true

[Term]
id: MOD:00816
name: S-stearoyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-stearoyl-L-cysteine." [DeltaMass:0, PubMed:2371783, PubMed:3143715, PubMed:8761467, RESID:AA0407]
comment: From DeltaMass: Average Mass: 266
subset: PSI-MOD-slim
synonym: "(R)-2-amino-3-(octadecanoylsulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(octadecanoylthio)propanoic acid" EXACT RESID-alternate []
synonym: "cysteine octadecanoate thioester" EXACT RESID-alternate []
synonym: "cysteine stearate thioester" EXACT RESID-alternate []
synonym: "LIPID S-stearoyl cysteine" EXACT UniProt-feature []
synonym: "S-stearoyl-L-cysteine" EXACT RESID-name []
synonym: "SSteCys" EXACT PSI-MOD-label []
synonym: "Stearoylation" EXACT DeltaMass-label []
xref: DiffAvg: "266.47"
xref: DiffFormula: "C 18 H 34 N 0 O 1 S 0"
xref: DiffMono: "266.260966"
xref: Formula: "C 21 H 39 N 1 O 2 S 1"
xref: MassAvg: "369.61"
xref: MassMono: "369.270150"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0283
is_a: MOD:02005 ! S-acylated L-cysteine
is_a: MOD:02006 ! S-stearoylated residue

[Term]
id: MOD:00817
name: 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan." [ChEBI:35304, PubMed:16407988, PubMed:8168130, RESID:AA0408]
synonym: "(2S,3aR,8aS)-3a-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid" EXACT RESID-systematic []
synonym: "(2S,3R)-3-geranyl-2,3-dihydro-2,N(alpha)-cyclo-L-tryptophan" EXACT RESID-alternate []
synonym: "3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan" EXACT RESID-name []
synonym: "3'Ger2'N2cycTrp" EXACT PSI-MOD-label []
synonym: "LIPID 3'-geranyl-2',N2-cyclotryptophan" EXACT UniProt-feature []
xref: DiffAvg: "136.24"
xref: DiffFormula: "C 10 H 16 N 0 O 0"
xref: DiffMono: "136.125201"
xref: Formula: "C 21 H 26 N 2 O 1"
xref: MassAvg: "322.45"
xref: MassMono: "322.204513"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0026
is_a: MOD:00601 ! cyclized residue
is_a: MOD:01115 ! isoprenylated tryptophan

[Term]
id: MOD:00818
name: glycosylphosphatidylinositolated residue
def: "A protein modification that effectively converts a residue to a glycosylphosphatidylinositolethanolamidated." [PubMed:12643538, Unimod:394#C-term]
synonym: "glycosylphosphatidylinositol" RELATED Unimod-description []
synonym: "GPIanchor" RELATED Unimod-interim []
synonym: "GPIRes" EXACT PSI-MOD-label []
synonym: "LIPID GPI-anchor amidated carboxyl end" EXACT UniProt-feature []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:394"
xref: uniprot.ptm:PTM-0139
is_a: MOD:00764 ! glycoconjugated residue
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:00819
name: L-2-aminobutanoic acid (Glu)
def: "A protein modification that effectively converts an L-glutamic acid residue to L-2-aminobutanoic acid." [ChEBI:35619, DeltaMass:0, PubMed:11740505, RESID:AA0409]
synonym: "(S)-2-aminobutanoic acid" EXACT RESID-systematic []
synonym: "Abu" EXACT DeltaMass-label []
synonym: "Abu" EXACT PSI-MOD-label []
synonym: "alpha-amino-n-butyric acid" EXACT PSI-MOD-alternate []
synonym: "alpha-aminobutyric acid" EXACT PSI-MOD-alternate []
synonym: "butyrine" EXACT PSI-MOD-alternate []
synonym: "dCbxGlu" EXACT PSI-MOD-alternate []
synonym: "L-2-amino-n-butyric acid" EXACT RESID-alternate []
synonym: "L-2-aminobutanoic acid" EXACT RESID-name []
synonym: "L-2-aminobutyric acid" EXACT RESID-alternate []
synonym: "L-alpha-amino-n-butyric acid" EXACT RESID-alternate []
synonym: "L-alpha-aminobutyric acid" EXACT RESID-alternate []
synonym: "L-butyrine" EXACT RESID-alternate []
xref: DiffAvg: "-44.01"
xref: DiffFormula: "C -1 H 0 N 0 O -2"
xref: DiffMono: "-43.989829"
xref: Formula: "C 4 H 7 N 1 O 1"
xref: MassAvg: "85.11"
xref: MassMono: "85.052764"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:00820
name: 2-imino-alanine 5-imidazolinone glycine
def: "A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue to form 2-imino-alanine 5-imidazolinone glycine." [PubMed:16627946, RESID:AA0410]
comment: Cross-link 2; carboxamidine.
synonym: "(2-ethanimidoyl-5-oxo-4,5-dihydro-1H-imidazol-1-yl)acetic acid" EXACT RESID-systematic []
synonym: "2,N-didehydroalanyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "2-(1-iminoethyl)-1-carboxymethyl-1-imidazolin-5-one" EXACT RESID-alternate []
synonym: "2-imino-alanine 5-imidazolinone glycine" EXACT RESID-name []
synonym: "2-imino-alanyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "[2-(1-iminoethyl)-5-oxo-4,5-dihydro-imidazol-1-yl]-acetic acid" EXACT RESID-alternate []
synonym: "alanyl-5-imidazolinone glycine" EXACT RESID-alternate []
synonym: "para-hydroxybenzylidene-imidazolidinone chromophore" EXACT RESID-alternate []
synonym: "red fluorescent protein zRFP574 chromophore" EXACT RESID-alternate []
xref: DiffAvg: "-64.04"
xref: DiffFormula: "C -1 H -4 N 0 O -3"
xref: DiffMono: "-64.016044"
xref: Formula: "C 5 H 4 N 2 O 1"
xref: MassAvg: "108.10"
xref: MassMono: "108.032363"
xref: Origin: "D, G"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02043 ! crosslinked L-aspartic acid residue
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:01882 ! 5-imidazolinone ring crosslinked residues (Gly)

[Term]
id: MOD:00821
name: S-(L-alanyl)-L-cysteine
def: "A protein modification that effectively crosslinks an L-alanine residue and an L-cysteine residue by a thioester bond to form S-(L-alanyl)-L-cysteine." [PubMed:11807079, RESID:AA0411]
comment: Cross-link 2.
synonym: "(2R)-2-amino-3-([(2S)-2-aminopropanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "alanine cysteine thioester" EXACT RESID-alternate []
synonym: "CROSSLNK Alanyl cysteine thioester (Cys-Ala)" EXACT UniProt-feature []
synonym: "S-(2-aminopropanoyl)cysteine" EXACT RESID-alternate []
synonym: "S-(L-alanyl)-L-cysteine" EXACT RESID-name []
synonym: "XLNK1AlaSCys" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 6 H 9 N 2 O 2 S 1"
xref: MassAvg: "173.21"
xref: MassMono: "173.038474"
xref: Origin: "A, C"
xref: Source: "hypothetical"
xref: TermSpec: "C-term"
is_a: MOD:00395 ! thioester crosslinked residues
is_a: MOD:02040 ! crosslinked L-alanine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00822
name: S-(L-leucyl)-L-cysteine
def: "A protein modification that effectively crosslinks an L-leucine residue and an L-cysteine residue by a thioester bond to form S-(L-leucyl)-L-cysteine." [PubMed:12591958, RESID:AA0412]
comment: Cross-link 2.
synonym: "(2R)-2-amino-3-([(2S)-2-amino-4-methylpentanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Leucyl cysteine thioester (Cys-Leu)" EXACT UniProt-feature []
synonym: "leucine cysteine thioester" EXACT RESID-alternate []
synonym: "S-(2-amino-4-methylpentanoyl)cysteine" EXACT RESID-alternate []
synonym: "S-(L-leucyl)-L-cysteine" EXACT RESID-name []
synonym: "XLNK1LeuSCys" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 9 H 15 N 2 O 2 S 1"
xref: MassAvg: "215.29"
xref: MassMono: "215.085424"
xref: Origin: "C, L"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00395 ! thioester crosslinked residues
is_a: MOD:02050 ! crosslinked L-leucine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00823
name: S-(L-methionyl)-L-cysteine
def: "A protein modification that effectively crosslinks an L-methionine residue and an L-cysteine residue by a thioester bond to form S-(L-methionyl)-L-cysteine." [PubMed:12146974, RESID:AA0413]
comment: Cross-link 2.
synonym: "(2R)-2-amino-3-([(2S)-2-amino-4-(methylsulfanyl)butanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Methionyl cysteine thioester (Cys-Met)" EXACT UniProt-feature []
synonym: "methionine cysteine thioester" EXACT RESID-alternate []
synonym: "S-(2-amino-4-methylthiobutanoyl)cysteine" EXACT RESID-alternate []
synonym: "S-(L-methionyl)-L-cysteine" EXACT RESID-name []
synonym: "XLNK1MetSCys" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 8 H 13 N 2 O 2 S 2"
xref: MassAvg: "233.32"
xref: MassMono: "233.041845"
xref: Origin: "C, M"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00395 ! thioester crosslinked residues
is_a: MOD:02052 ! crosslinked L-methionine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00824
name: dehydroalanine (Tyr)
def: "A protein modification that effectively converts an L-tyrosine residue to dehydroalanine." [PubMed:10220322, PubMed:1547888, PubMed:1815586, PubMed:2914619, PubMed:6838602, PubMed:7947813, PubMed:8239649, RESID:AA0181#TYR, Unimod:400]
comment: incidental to RESID:AA0178
synonym: "2,3-didehydroalanine" EXACT RESID-alternate []
synonym: "2-aminoacrylic acid" EXACT RESID-alternate []
synonym: "2-aminopropenoic acid" EXACT RESID-systematic []
synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate []
synonym: "anhydroserine" EXACT RESID-alternate []
synonym: "dehydroalanine" EXACT RESID-name []
synonym: "Dha" EXACT RESID-alternate []
synonym: "dHAla(Tyr)" EXACT PSI-MOD-label []
xref: DiffAvg: "-94.11"
xref: DiffFormula: "C -6 H -6 N 0 O -1"
xref: DiffMono: "-94.041865"
xref: Formula: "C 3 H 3 N 1 O 1"
xref: MassAvg: "69.06"
xref: MassMono: "69.021464"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:400"
xref: uniprot.ptm:PTM-0647
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01168 ! dehydroalanine

[Term]
id: MOD:00825
name: S-(L-phenylalanyl)-L-cysteine
def: "A protein modification that effectively crosslinks an L-phenylalanine residue and an L-cysteine residue by a thioester bond to form S-(L-phenylalaninyl)-L-cysteine." [PubMed:12591958, RESID:AA0414]
comment: Cross-link 2.
synonym: "(2R)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Phenylalanyl cysteine thioester (Cys-Phe)" EXACT UniProt-feature []
synonym: "phenylalanine cysteine thioester" EXACT RESID-alternate []
synonym: "S-(2-amino-3-phenylpropanoyl)cysteine" EXACT RESID-alternate []
synonym: "S-(L-phenylalanyl)-L-cysteine" EXACT RESID-name []
synonym: "XLNK1PheSCys" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 12 H 13 N 2 O 2 S 1"
xref: MassAvg: "249.31"
xref: MassMono: "249.069774"
xref: Origin: "C, F"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00395 ! thioester crosslinked residues
is_a: MOD:02053 ! crosslinked L-phenylalanine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00826
name: S-(L-threonyl)-L-cysteine
def: "A protein modification that effectively crosslinks an L-threonine residue and an L-cysteine residue by a thioester bond to form S-(L-threonyl)-L-cysteine." [PubMed:15268951, RESID:AA0415]
comment: Cross-link 2.
synonym: "(2R)-2-amino-3-([(2S,3R)-2-amino-3-hydroxybutanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Threonyl cysteine thioester (Cys-Thr)" EXACT UniProt-feature []
synonym: "S-(2-amino-3-hydroxybutanoyl)cysteine" EXACT RESID-alternate []
synonym: "S-(L-threonyl)-L-cysteine" EXACT RESID-name []
synonym: "threonine cysteine thioester" EXACT RESID-alternate []
synonym: "XLNK1ThrSCys" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 7 H 11 N 2 O 3 S 1"
xref: MassAvg: "203.24"
xref: MassMono: "203.049038"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00395 ! thioester crosslinked residues
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00827
name: S-(L-tyrosyl)-L-cysteine
def: "A protein modification that effectively crosslinks an L-tyrosine residue and an L-cysteine residue by a thioester bond to form S-(L-tyrosyl)-L-cysteine." [PubMed:11807079, RESID:AA0416]
comment: Cross-link 2.
synonym: "(2R)-2-amino-3-([(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Tyrosyl cysteine thioester (Cys-Tyr)" EXACT UniProt-feature []
synonym: "S-(L-tyrosyl)-L-cysteine" EXACT RESID-name []
synonym: "S-[2-amino-3-(4-hydoxyphenyl)propanoyl]cysteine" EXACT RESID-alternate []
synonym: "tyrosine cysteine thioester" EXACT RESID-alternate []
synonym: "XLNK1TyrSCys" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 12 H 13 N 2 O 3 S 1"
xref: MassAvg: "265.31"
xref: MassMono: "265.064688"
xref: Origin: "C, Y"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00395 ! thioester crosslinked residues
is_a: MOD:02058 ! crosslinked L-tyrosine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00828
name: S-(L-tryptophanyl)-L-cysteine
def: "A protein modification that effectively crosslinks an L-tryptophan residue and an L-cysteine residue by a thioester bond to form S-(L-tryptophanyl)-L-cysteine." [PubMed:16030216, RESID:AA0417]
comment: Cross-link 2.
synonym: "(2R)-2-amino-3-([(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Tryptophanyl cysteine thioester (Cys-Trp)" EXACT UniProt-feature []
synonym: "S-(L-tryptophanyl)-L-cysteine" EXACT RESID-name []
synonym: "S-[2-amino-3-(1H-indol-3-yl)propanoyl]cysteine" EXACT RESID-alternate []
synonym: "tryptophan cysteine thioester" EXACT RESID-alternate []
synonym: "XLNK1TrpSCys" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 14 H 14 N 3 O 2 S 1"
xref: MassAvg: "288.35"
xref: MassMono: "288.080673"
xref: Origin: "C, W"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00395 ! thioester crosslinked residues
is_a: MOD:02057 ! crosslinked L-tryptophan residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00829
name: O-(L-phenylalanyl)-L-serine
def: "A protein modification that effectively crosslinks an L-phenylalanine residue and an L-serine residue by an ester bond to form S-(L-phenylalaninyl)-L-serine." [PubMed:12591958, RESID:AA0418]
comment: Cross-link 2.
synonym: "(2S)-2-amino-3-([(2S)-2-amino-3-phenylpropanoyl]oxy)propanoic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Phenylalanyl serine ester (Ser-Phe)" EXACT UniProt-feature []
synonym: "O-(2-amino-3-phenylpropanoyl)serine" EXACT RESID-alternate []
synonym: "O-(L-phenylalanyl)-L-serine" EXACT RESID-name []
synonym: "phenylalanine serine ester" EXACT RESID-alternate []
synonym: "XLNK1PheOSer" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 12 H 13 N 2 O 3"
xref: MassAvg: "233.25"
xref: MassMono: "233.092617"
xref: Origin: "F, S"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00885 ! ester crosslinked residues
is_a: MOD:02053 ! crosslinked L-phenylalanine residue
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00830
name: N-methyl-L-proline
def: "A protein modification that effectively converts an L-proline residue to an N-methyl-L-proline." [PubMed:3127388, RESID:AA0419]
comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].
subset: PSI-MOD-slim
synonym: "(S)-1-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "1-methylpyrrolidine-2-carboxylic acid" EXACT RESID-alternate []
synonym: "hygric acid" EXACT RESID-alternate []
synonym: "MOD_RES N-methylproline" EXACT UniProt-feature []
synonym: "N-methyl-L-proline" EXACT RESID-name []
synonym: "N-methylated L-proline" EXACT PSI-MOD-alternate []
synonym: "NMePro" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 6 H 10 N 1 O 1"
xref: MassAvg: "112.15"
xref: MassMono: "112.076239"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0219
is_a: MOD:01417 ! monomethylated proline
is_a: MOD:01462 ! N-methylated proline
is_a: MOD:01680 ! alpha-amino monomethylated residue

[Term]
id: MOD:00831
name: N4-(N-acetylamino)glucosyl-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine." [PubMed:111247, PubMed:1694179, PubMed:5490222, RESID:AA0151#var]
subset: PSI-MOD-slim
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "N4GlcNAcAsn" EXACT PSI-MOD-label []
synonym: "CARBOHYD N-linked (GlcNAc) asparagine" EXACT UniProt-feature []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "C 12 H 19 N 3 O 7"
xref: MassAvg: "317.30"
xref: MassMono: "317.122300"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0527
is_a: MOD:00448 ! mono-N-acetylaminoglucosylated residue
is_a: MOD:01674 ! N4-(N-acetylamino)hexosyl-L-asparagine

[Term]
id: MOD:00832
name: N4-(N-acetylamino)galactosyl-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminogalactosyl)-L-asparagine." [PubMed:8262914, RESID:AA0420]
synonym: "(2S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "N4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)-L-asparagine" EXACT RESID-alternate []
synonym: "N4-(2-acetylamino-2-deoxy-beta-D-galactopyranosyl)-L-asparagine" EXACT RESID-alternate []
synonym: "N4-(N-acetylamino)galactosyl-L-asparagine" EXACT RESID-name []
synonym: "N4-(N-acetylgalactosaminyl)asparagine" EXACT RESID-alternate []
synonym: "N4-asparagine-beta-N-acetylgalactosaminide" EXACT RESID-alternate []
synonym: "N4-glycosyl-L-asparagine" EXACT RESID-alternate []
synonym: "N4-glycosylasparagine" EXACT RESID-alternate []
synonym: "N4GalNAcAsn" EXACT PSI-MOD-label []
synonym: "CARBOHYD N-linked (GalNAc) asparagine" EXACT UniProt-feature []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "C 12 H 19 N 3 O 7"
xref: MassAvg: "317.30"
xref: MassMono: "317.122300"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0512
is_a: MOD:00563 ! mono-N-acetylaminogalactosylated residue
is_a: MOD:01674 ! N4-(N-acetylamino)hexosyl-L-asparagine

[Term]
id: MOD:00833
name: N4-glucosyl-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to N4-glucosyl-asparagine." [PubMed:1569073, PubMed:3410849, RESID:AA0421]
synonym: "(2S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD N-linked (Glc)" EXACT UniProt-feature []
synonym: "N4-(D-glucopyranosyl)-L-asparagine" EXACT RESID-alternate []
synonym: "N4-asparagine-glucoside" EXACT RESID-alternate []
synonym: "N4-glucosyl-L-asparagine" EXACT RESID-name []
synonym: "N4-glucosylasparagine" EXACT RESID-alternate []
synonym: "N4-glycosyl-L-asparagine" EXACT RESID-alternate []
synonym: "N4-glycosylasparagine" EXACT RESID-alternate []
synonym: "N4GlcAsn" EXACT PSI-MOD-label []
synonym: "CARBOHYD N-linked (Glc) asparagine" EXACT UniProt-feature []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 10 H 16 N 2 O 7"
xref: MassAvg: "276.25"
xref: MassMono: "276.095751"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0517
is_a: MOD:00433 ! monoglucosylated residue
is_a: MOD:01346 ! N4-hexosylated asparagine

[Term]
id: MOD:00834
name: O-(N-acetylamino)fucosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O3-(N-acetamino)fucosylserine." [PubMed:11342554, PubMed:12010970, RESID:AA0422]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-fucopyranosyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "O-(2-acetylamino-2-deoxy-beta-D-fucopyranosyl)-L-serine" EXACT RESID-alternate []
synonym: "O-(N-acetylamino)fucosyl-L-serine" EXACT RESID-name []
synonym: "O-(N-acetylfucosaminyl)serine" EXACT RESID-alternate []
synonym: "O-seryl-beta-N-acetylfucosaminide" EXACT RESID-alternate []
synonym: "O3-(2-acetamido-2-deoxy-beta-D-fucopyranosyl)-L-serine" EXACT RESID-alternate []
synonym: "O3-(N-acetylfucosaminyl)serine" EXACT RESID-alternate []
synonym: "OFucNAcSer" EXACT PSI-MOD-label []
synonym: "CARBOHYD O-linked (FucNAc) serine" EXACT UniProt-feature []
xref: DiffAvg: "187.19"
xref: DiffFormula: "C 8 H 13 N 1 O 4"
xref: DiffMono: "187.084458"
xref: Formula: "C 11 H 18 N 2 O 6"
xref: MassAvg: "274.27"
xref: MassMono: "274.116486"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0553
is_a: MOD:00002 ! O-glycosyl-L-serine

[Term]
id: MOD:00835
name: L-3-oxoalanine (Ser)
def: "A protein modification that effectively converts an L-serine residue to L-oxoalanine." [DeltaMass:349, PubMed:14563551, PubMed:7628016, PubMed:8681943, PubMed:9276974, PubMed:9478923, RESID:AA0185#SER, Unimod:401#S]
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-oxopropanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-oxopropionic acid" EXACT RESID-alternate []
synonym: "C(alpha)-formylglycine" RELATED RESID-misnomer []
synonym: "dehydrogenated serine residue" RELATED Unimod-description []
synonym: "Didehydro" RELATED PSI-MS-label []
synonym: "formylglycine" RELATED Unimod-alternate []
synonym: "formylglycine (from serine)" EXACT DeltaMass-label []
synonym: "L-3-oxoalanine" EXACT RESID-name []
synonym: "L-amino-malonic acid semialdehyde" EXACT RESID-alternate []
synonym: "L-aminomalonaldehydic acid" EXACT RESID-alternate []
synonym: "L-serinesemialdehyde" RELATED RESID-misnomer []
synonym: "MOD_RES 3-oxoalanine (Ser)" EXACT UniProt-feature []
synonym: "oxoalanine" RELATED Unimod-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 3 H 3 N 1 O 2"
xref: MassAvg: "85.06"
xref: MassMono: "85.016378"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:401"
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01169 ! L-3-oxoalanine
is_a: MOD:01888 ! didehydrogenated residue

[Term]
id: MOD:00836
name: deuterium disubstituted residue
def: "A protein modification that effectively substitutes two (2)H deuterium atoms for two (1)H protium atoms." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "D(H)2Res" EXACT PSI-MOD-label []
is_a: MOD:00786 ! deuterium substituted residue

[Term]
id: MOD:00837
name: deuterium tetrasubstituted residue
def: "A protein modification that effectively substitutes four (2)H deuterium atoms for four (1)H protium atoms." [PubMed:18688235]
synonym: "D(H)4Res" EXACT PSI-MOD-label []
is_a: MOD:00786 ! deuterium substituted residue

[Term]
id: MOD:00838
name: 3x(2)H labeled L-leucine
def: "A protein modification that effectively substitutes three (1)H protium atoms with three (2)H deuterium atoms to produce 3x(2)H labeled L-leucine." [Unimod:262#L]
synonym: "D(H)3Leu" EXACT PSI-MOD-label []
synonym: "Label:2H(3)" RELATED PSI-MS-label []
synonym: "Trideuteration" RELATED Unimod-description []
xref: DiffAvg: "3.02"
xref: DiffFormula: "(1)H -3 (2)H 3"
xref: DiffMono: "3.018830"
xref: Formula: "C 6 (1)H 8 (2)H 3 N 1 O 1"
xref: MassAvg: "116.10"
xref: MassMono: "116.102894"
xref: Origin: "L"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:262"
is_a: MOD:00585 ! deuterium trisubstituted residue
is_a: MOD:00911 ! modified L-leucine residue

[Term]
id: MOD:00839
name: (2)H deuterium labeled residue
def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing deuteriumm, (2)H." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00702 ! isotope labeled residue

[Term]
id: MOD:00840
name: isocyanate reagent derivatized residue
def: "A protein modification produced by formation of an adduct with an isocyanate compound." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00841
name: isothiocyanate reagent derivatized residue
def: "A protein modification produced by formation of an adduct with an isothiocyanate compound." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00842
name: (13)C labeled residue
def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (13)C." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00702 ! isotope labeled residue

[Term]
id: MOD:00843
name: (15)N labeled residue
def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (15)N." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00702 ! isotope labeled residue

[Term]
id: MOD:00844
name: (18)O labeled residue
def: "A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (18)O." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00702 ! isotope labeled residue

[Term]
id: MOD:00845
name: (18)O substituted residue
def: "A protein modification that effectively substitutes one or more (18)O atoms for (16)O atoms." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00844 ! (18)O labeled residue

[Term]
id: MOD:00846
name: levuglandinyl (prostaglandin H2) adduct
def: "stub" [PubMed:18688235]
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00847
name: (18)O disubstituted residue
def: "A protein modification that effectively substitutes two (18)O atom for two (16)O atoms." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00845 ! (18)O substituted residue

[Term]
id: MOD:00848
name: reagent derivatized residue
def: "A protein modification that is produced by formation of an adduct with a particular compound used as a reagent." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00849
name: potassium containing modified residue
def: "A protein modification that effectively substitutes a potassium atom for a hydrogen atom." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "KRes" EXACT PSI-MOD-label []
is_a: MOD:00698 ! metal or metal cluster containing modified residue

[Term]
id: MOD:00850
name: unnatural residue
def: "A protein modification that inserts or replaces a residue with an unnatural residue that is not considered to be derived from a natural residue by some chemical process." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00851
name: (18)O labeled deamidated residue
def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with (18)O." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00400 ! deamidated residue
is_a: MOD:00844 ! (18)O labeled residue

[Term]
id: MOD:00852
name: 1x(18)O labeled deamidated residue
def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with one (18)O." [PubMed:8382902, Unimod:366]
subset: PSI-MOD-slim
xref: DiffAvg: "2.99"
xref: DiffFormula: "H -1 N -1 (18)O 1"
xref: DiffMono: "2.988262"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:366"
is_a: MOD:00851 ! (18)O labeled deamidated residue

[Term]
id: MOD:00853
name: 2x(18)O labeled deamidated residue
def: "A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with two (18)O." [PubMed:18688235]
subset: PSI-MOD-slim
xref: DiffAvg: "4.99"
xref: DiffFormula: "H -1 N -1 (16)O -1 (18)O 2"
xref: DiffMono: "4.992508"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00851 ! (18)O labeled deamidated residue

[Term]
id: MOD:00854
name: protonated L-lysine (L-lysinium) residue
def: "A protein modification that effectively converts an L-lysine to L-lysinium (protonated L-lysine)." [PubMed:18688235]
comment: Some sources compute the difference formula for charged, quatenary modified lysine based on protonated lysine rather than neutral lysine residue. In such cases, a comparable difference formula can be calculated based on this derivative.
subset: PSI-MOD-slim
xref: DiffAvg: "1.01"
xref: DiffFormula: "C 0 H 1 N 0 O 0"
xref: DiffMono: "1.007276"
xref: FormalCharge: "1+"
xref: Formula: "C 6 H 13 N 2 O 1"
xref: MassAvg: "129.18"
xref: MassMono: "129.102239"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01699 ! protonated residue

[Term]
id: MOD:00855
name: N6,N6,N6-trimethyl-L-lysine (from L-lysinium residue)
def: "A protein modification that effectively converts an L-lysinium (N6-protonated L-lysine) residue to an N6,N6,N6-trimethyl-L-lysine." [DeltaMass:0, OMSSA:15, PubMed:12590383, PubMed:3145979, PubMed:4304194, PubMed:6778808, PubMed:7093227, PubMed:8453381, Unimod:37#K]
comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N6Me3+Lys process (MOD:00083) accounts for both protonation and trimethylation.
subset: PSI-MOD-slim
synonym: "N6Me3Lys" EXACT PSI-MOD-label []
synonym: "trimethylk" EXACT OMSSA-label []
xref: DiffAvg: "42.08"
xref: DiffFormula: "C 3 H 6 N 0 O 0"
xref: DiffMono: "42.046402"
xref: FormalCharge: "1+"
xref: Formula: "C 9 H 19 N 2 O 1"
xref: MassAvg: "171.26"
xref: MassMono: "171.149190"
xref: Origin: "MOD:00854"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:37"
is_a: MOD:00430 ! trimethylated residue
relationship: derives_from MOD:00854 ! protonated L-lysine (L-lysinium) residue

[Term]
id: MOD:00856
name: protonated L-alanine (L-alaninium) residue
def: "A protein modification that effectively converts an L-alanine residue to an L-alaninium (protonated L-alanine)." [PubMed:18688235]
subset: PSI-MOD-slim
xref: DiffAvg: "1.01"
xref: DiffFormula: "C 0 H 1 N 0 O 0"
xref: DiffMono: "1.007276"
xref: FormalCharge: "1+"
xref: Formula: "C 3 H 7 N 1 O 1"
xref: MassAvg: "73.09"
xref: MassMono: "73.052215"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00901 ! modified L-alanine residue
is_a: MOD:01700 ! alpha-amino protonated residue

[Term]
id: MOD:00857
name: N,N,N-trimethyl-L-alanine (from L-alaninium)
def: "A protein modification that effectively converts an L-alaninium (protonated L-alanine) residue to an N,N,N-trimethyl-L-alanine." [PubMed:12590383, PubMed:332162, PubMed:3979397, PubMed:6778808, PubMed:7715456, Unimod:37#A]
comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ala process (MOD:00071) accounts for both protonation and trimethylation.
subset: PSI-MOD-slim
synonym: "N2Me3Ala" EXACT PSI-MOD-label []
xref: DiffAvg: "42.08"
xref: DiffFormula: "C 3 H 6 N 0 O 0"
xref: DiffMono: "42.046402"
xref: FormalCharge: "1+"
xref: Formula: "C 6 H 13 N 1 O 1"
xref: MassAvg: "115.18"
xref: MassMono: "115.099165"
xref: Origin: "MOD:00856"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:37"
is_a: MOD:01687 ! alpha-amino trimethylated residue
relationship: derives_from MOD:00856 ! protonated L-alanine (L-alaninium) residue

[Term]
id: MOD:00858
name: D-alanine (Ser)
def: "A protein modification that effectively converts an L-serine residue to D-alanine." [PubMed:7961627, RESID:AA0191#SER]
synonym: "(R)-2-aminopropanoic acid" EXACT RESID-systematic []
synonym: "D-Ala(Ser)" EXACT PSI-MOD-label []
synonym: "D-alanine" EXACT RESID-name []
synonym: "MOD_RES D-alanine (Ser)" EXACT UniProt-feature []
xref: DiffAvg: "-16.00"
xref: DiffFormula: "C 0 H 0 N 0 O -1"
xref: DiffMono: "-15.994915"
xref: Formula: "C 3 H 5 N 1 O 1"
xref: MassAvg: "71.08"
xref: MassMono: "71.037114"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0113
is_a: MOD:00862 ! D-alanine
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01161 ! deoxygenated residue

[Term]
id: MOD:00859
name: modified residue that can arise from different natural residues
def: "A protein modification that can be derived from different natural residues by different chemical processes." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00860
name: sulfur containing modified residue
def: "A protein modification that produces an amino acid residue containing an exogenous sulfur atom." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00861
name: phosphorus containing modified residue
def: "A protein modification that produces an amino acid residue containing a phosphorus atom." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00862
name: D-alanine
def: "A protein modification that effectively converts a source amino acid residue to D-alanine." [ChEBI:29949, PubMed:7287302, PubMed:7961627, RESID:AA0191]
synonym: "(R)-2-aminopropanoic acid" EXACT RESID-systematic []
synonym: "D-alanine" EXACT RESID-name []
synonym: "MOD_RES D-alanine (Ala)" EXACT UniProt-feature []
synonym: "MOD_RES D-alanine (Ser)" EXACT UniProt-feature []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 3 H 5 N 1 O 1"
xref: MassAvg: "71.08"
xref: MassMono: "71.037114"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:00863
name: D-allo-threonine
def: "A protein modification that effectively converts an L-threonine residue to D-allo-threonine." [ChEBI:32826, PubMed:18025465, PubMed:6893271, RESID:AA0199]
synonym: "(2R,3R)-2-amino-3-hydroxybutanoic acid" EXACT RESID-systematic []
synonym: "D-Thr" EXACT PSI-MOD-label []
synonym: "D-threonine" EXACT RESID-name []
synonym: "MOD_RES D-threonine" EXACT UniProt-feature []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 4 H 7 N 1 O 2"
xref: MassAvg: "101.10"
xref: MassMono: "101.047678"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0310
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:00864
name: tris-L-cysteinyl L-histidino diiron disulfide
def: "A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-histidino diiron disulfide." [PubMed:17766439, PubMed:17766440, RESID:AA0438]
comment: Cross-link 4.
synonym: "CDGSH domain iron-sulfur cluster" EXACT RESID-alternate []
synonym: "di-mu-sulfido(bis-S-cysteinyliron)(S-cysteinyl-N3'-histidinoiron)" EXACT RESID-systematic []
synonym: "METAL Iron-sulfur (2Fe-2S)" EXACT UniProt-feature []
synonym: "METAL Iron-sulfur (2Fe-2S); via pros nitrogen" EXACT UniProt-feature []
synonym: "tris-L-cysteinyl L-histidino diiron disulfide" EXACT RESID-name []
xref: DiffAvg: "171.78"
xref: DiffFormula: "C 0 Fe 2 H -4 N 0 O 0 S 2"
xref: DiffMono: "171.783814"
xref: FormalCharge: "2-"
xref: Formula: "C 15 Fe 2 H 18 N 6 O 4 S 5"
xref: MassAvg: "618.34"
xref: MassMono: "617.870280"
xref: Origin: "C, C, C, H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:00865
name: N-aspartyl-glycosylsphingolipidinositolethanolamine
def: "A protein modification that effectively converts an L-aspartic acid residue to N-aspartyl-glycosylsphingolipidinositolethanolamine." [RESID:AA0439]
synonym: "GSIAsp" EXACT PSI-MOD-label []
synonym: "LIPID GPI-like-anchor amidated aspartate" EXACT UniProt-feature []
synonym: "N-aspartyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 6 H 12 N 2 O 7 P 1"
xref: MassAvg: "255.14"
xref: MassMono: "255.038212"
xref: Origin: "D"
xref: Source: "hypothetical"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0322
is_a: MOD:00466 ! glycosylsphingolipidinositolated residue
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:00866
name: dihydroxylated proline
def: "A protein modification that effectively converts an L-proline residue to one of several dihydroxylated proline residues, such as (2S,3R,4R)-3,4-dihydroxyproline or (2S,3R,4S)-3,4-dihydroxyproline." [PubMed:18688235]
synonym: "Hy2Pro" EXACT PSI-MOD-label []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0024
is_a: MOD:00428 ! dihydroxylated residue
is_a: MOD:00678 ! hydroxylated proline

[Term]
id: MOD:00867
name: L-cysteinyl-L-selenocysteine (Cys-Cys)
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-cysteine converted to an L-selenocysteine residue to form L-cysteinyl-L-selenocystine." [PubMed:10801974, PubMed:12911312, PubMed:17177418, RESID:AA0358#CYS]
comment: Cross-link 2.
synonym: "(R,R)-2-amino-3-[3-(2-aminopropanoic acid)sulfanyl]selanylpropanoic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Cysteinyl-selenocysteine (Cys-Sec)" EXACT UniProt-feature []
synonym: "CROSSLNK Cysteinyl-selenocysteine (Sec-Cys)" EXACT UniProt-feature []
synonym: "L-cysteinyl-L-selenocysteine" EXACT RESID-name []
xref: DiffAvg: "44.90"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1 Se 1"
xref: DiffMono: "45.928800"
xref: Formula: "C 6 H 8 N 2 O 2 S 1 Se 1"
xref: MassAvg: "251.17"
xref: MassMono: "251.947170"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01627 ! L-cysteinyl-L-selenocysteine

[Term]
id: MOD:00868
name: natural, non-standard encoded residue
def: "A protein modification that inserts or replaces a residue with a natural, non-standard encoded residue, such as N-formyl-L-methionine, L-selenocysteine, or L-pyrrolysine." [PubMed:18688235]
comment: These are produced exclusively by modification of amino acids acylated to special tRNA before incorporation by ribosomes into proteins. For this reason, they have also been referred to as pre-translational modifications.
subset: PSI-MOD-slim
xref: Origin: "X"
xref: Source: "natural"
is_a: MOD:00009 ! natural residue

[Term]
id: MOD:00869
name: L-alanine residue (Asp)
def: "A protein modification that effectively converts an L-aspartic acid residue to L-alanine." [PubMed:17138938, RESID:AA0001#ASP]
comment: This has been reported to occur by a natural process of beta-decarboxylation.
synonym: "(2S)-2-aminopropanoic acid" EXACT RESID-systematic []
synonym: "2-aminopropionic acid" EXACT RESID-alternate []
synonym: "2-azanylpropanoic acid" EXACT RESID-alternate []
synonym: "alpha-alanine" EXACT RESID-alternate []
synonym: "alpha-aminopropionic acid" EXACT RESID-alternate []
synonym: "Asp(Ala)" EXACT PSI-MOD-label []
synonym: "L-alanine" EXACT RESID-name []
synonym: "MOD_RES Beta-decarboxylated aspartate" EXACT UniProt-feature []
xref: DiffAvg: "-44.01"
xref: DiffFormula: "C -1 H 0 N 0 O -2"
xref: DiffMono: "-43.989829"
xref: Formula: "C 3 H 5 N 1 O 1"
xref: MassAvg: "71.08"
xref: MassMono: "71.037114"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0314
is_a: MOD:00904 ! modified L-aspartic acid residue
is_a: MOD:02088 ! natural, standard, encoded residue substitution

[Term]
id: MOD:00870
name: phenyl isocyanate derivatized residue
def: "A protein modification produced by formation of an adduct with phenyl isocyanate." [Unimod:411]
comment: From Unimod with no citation.
subset: PSI-MOD-slim
synonym: "phenyl isocyanate" RELATED Unimod-description []
synonym: "Phenylisocyanate" RELATED PSI-MS-label []
xref: DiffAvg: "119.12"
xref: DiffFormula: "C 7 H 5 N 1 O 1"
xref: DiffMono: "119.037114"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:411"
is_a: MOD:00840 ! isocyanate reagent derivatized residue

[Term]
id: MOD:00871
name: (2)H5-phenyl isocyanate derivatized residue
def: "A protein modification produced by formation of an adduct with (2)H5-phenyl isocyanate." [Unimod:412]
comment: From Unimod with no citation.
subset: PSI-MOD-slim
synonym: "d5-phenyl isocyanate" RELATED Unimod-description []
synonym: "Phenylisocyanate:2H(5)" RELATED PSI-MS-label []
xref: DiffAvg: "124.07"
xref: DiffFormula: "C 7 (2)H 5 N 1 O 1"
xref: DiffMono: "124.068498"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:412"
relationship: derives_from MOD:00870 ! phenyl isocyanate derivatized residue
is_a: MOD:01431 ! (2)H deuterium tagged reagent

[Term]
id: MOD:00872
name: L-isoglutamyl monoglutamic acid
def: "OBSOLETE because redundant and identical to MOD:01970. Remap to MOD:01970." [PubMed:10747868, PubMed:15525938, PubMed:1680872, RESID:AA0202#var, Unimod:450]
synonym: "Glu" RELATED Unimod-interim []
synonym: "monoglutamyl" RELATED Unimod-description []
synonym: "N alpha -(gamma-Glutamyl)-Glu" EXACT DeltaMass-label []
xref: DiffAvg: "129.12"
xref: DiffFormula: "C 5 H 7 N 1 O 3"
xref: DiffMono: "129.042593"
xref: Formula: "C 10 H 14 N 2 O 6"
xref: MassAvg: "258.23"
xref: MassMono: "258.085186"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:01970"
xref: Unimod: "Unimod:450"
is_obsolete: true

[Term]
id: MOD:00873
name: L-isoglutamyl diglutamic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamic acid, forming an isopeptide bond with a diglutamic acid." [DeltaMass:0, PubMed:10747868, PubMed:1680872, RESID:AA0202#var, Unimod:451]
synonym: "diglutamyl" RELATED Unimod-description []
synonym: "GluGlu" RELATED Unimod-interim []
xref: DiffAvg: "258.23"
xref: DiffFormula: "C 10 H 14 N 2 O 6"
xref: DiffMono: "258.085186"
xref: Formula: "C 15 H 21 N 3 O 9"
xref: MassAvg: "387.35"
xref: MassMono: "387.127779"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:451"
is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid

[Term]
id: MOD:00874
name: L-isoglutamyl triglutamic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a triglutamic acid." [DeltaMass:0, PubMed:10747868, PubMed:1680872, RESID:AA0202#var, Unimod:452]
comment: From DeltaMass: Average Mass: 388.
synonym: "GluGluGlu" RELATED Unimod-interim []
synonym: "N alpha -(gamma-Glutamyl)-Glu3" EXACT DeltaMass-label []
synonym: "triglutamyl" RELATED Unimod-description []
xref: DiffAvg: "387.35"
xref: DiffFormula: "C 15 H 21 N 3 O 9"
xref: DiffMono: "387.127779"
xref: Formula: "C 20 H 28 N 4 O 12"
xref: MassAvg: "516.46"
xref: MassMono: "516.170372"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:452"
is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid

[Term]
id: MOD:00875
name: L-isoglutamyl tetraglutamic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a tetraglutamic acid." [PubMed:10747868, PubMed:1680872, RESID:AA0202#var, Unimod:453]
synonym: "GluGluGluGlu" RELATED Unimod-interim []
synonym: "tetraglutamyl" RELATED Unimod-description []
xref: DiffAvg: "516.46"
xref: DiffFormula: "C 20 H 28 N 4 O 12"
xref: DiffMono: "516.170372"
xref: Formula: "C 25 H 35 N 5 O 15"
xref: MassAvg: "645.57"
xref: MassMono: "645.212965"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:453"
is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid

[Term]
id: MOD:00876
name: hexosaminylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosamine sugar group through a glycosidic bond." [Unimod:454]
synonym: "HexN" RELATED PSI-MS-label []
synonym: "Hexosamine" RELATED Unimod-description []
synonym: "Hexosamines (GalN, GlcN)" EXACT DeltaMass-label []
xref: DiffAvg: "161.16"
xref: DiffFormula: "C 6 H 11 N 1 O 4"
xref: DiffMono: "161.068808"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:454"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00877
name: imidoester crosslink dimethyl pimelimidate singly attached
def: "dimethyl pimelimidate modification from Unimod" [Unimod:455, URL:http\://www.piercenet.com/files/0668ss5.pdf]
synonym: "One end of crosslink attached, one end free" RELATED Unimod-description []
synonym: "Xlink:DMP-s" RELATED Unimod-interim []
xref: DiffAvg: "154.21"
xref: DiffFormula: "C 8 H 14 N 2 O 1"
xref: DiffMono: "154.110613"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:455"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00878
name: imidoester crosslink dimethyl pimelimidate doubly attached
def: "dimethyl pimelimidate modification from Unimod - Mechanism of the reaction of imidoesters with amines" [PubMed:7171546, Unimod:456, URL:http\://dx.doi.org/10.1021/ja00877a017]
synonym: "Both ends of crosslink attached to same peptide" RELATED Unimod-description []
synonym: "Xlink:DMP" RELATED Unimod-interim []
xref: DiffAvg: "122.17"
xref: DiffFormula: "C 7 H 10 N 2"
xref: DiffMono: "122.084398"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:456"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00879
name: naphthalene-2,3-dicarboxaldehyde
def: "modification from Unimod" [PubMed:2081203, Unimod:457]
synonym: "naphthalene-2,3-dicarboxaldehyde" RELATED Unimod-description []
synonym: "NDA" RELATED Unimod-interim []
xref: DiffAvg: "175.19"
xref: DiffFormula: "C 13 H 5 N 1"
xref: DiffMono: "175.042199"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:457"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00880
name: 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue
def: "A protein modification produced by formation of an adduct with 6x(13)C labeled 4-sulfophenyl isothiocyanate." [PubMed:15536630, PubMed:16526082, Unimod:464]
synonym: "4-sulfophenyl isothiocyanate (Heavy C13)" RELATED Unimod-description []
synonym: "SPITC:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "220.99"
xref: DiffFormula: "(12)C 1 (13)C 6 H 5 N 1 O 3 S 2"
xref: DiffMono: "220.991214"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:464"
relationship: derives_from MOD:00584 ! 4-sulfophenyl isothiocyanate derivatized residue
is_a: MOD:01428 ! (13)C isotope tagged reagent

[Term]
id: MOD:00881
name: N-reductive amination-D
def: "OBSOLETE because Unimod entry 465 megerd with 199. Remap to MOD:00552 DiMethyl-CH2D." [PubMed:9252331, Unimod:465]
xref: DiffAvg: "32.06"
xref: DiffFormula: "C 2 (2)H 4"
xref: DiffMono: "32.056407"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00552"
xref: Unimod: "Unimod:465"
is_obsolete: true

[Term]
id: MOD:00882
name: S-(2-aminoethyl)cysteine (Ser)
def: "A protein modification that effectively converts an L-serine residue to S-(2-aminoethyl)cysteine." [DeltaMass:171, PubMed:12923550, Unimod:472#S]
comment: From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex.
synonym: "AEC-MAEC" RELATED Unimod-interim []
synonym: "Aminoethyl Cysteinyl (AECys)" EXACT DeltaMass-label []
synonym: "aminoethylcysteine" RELATED Unimod-description []
xref: DiffAvg: "59.13"
xref: DiffFormula: "C 2 H 5 N 1 O -1 S 1"
xref: DiffMono: "59.019356"
xref: Formula: "C 5 H 10 N 2 O 1 S 1"
xref: MassAvg: "146.21"
xref: MassMono: "146.051384"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:472"
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:00883
name: C1-amidated residue
def: "A protein modification that effectively replaces a 1-carboxyl group (usually referred to as the alpha-carboxyl) with a carboxamido group." [DeltaMass:0, OMSSA:25, Unimod:2]
comment: The normal biological process involves formation of an amide of an amino acid residue in a peptide sequence where it is followed by a glycine and two basic residues, either arginine or lysine, although in some taxa only one basic residue is required. The peptide is cleaved after the basic residues, glycine is oxidized to hydroxyglycine, which decomposes to release a carboxamide C-terminal [JSG].
subset: PSI-MOD-slim
synonym: "alpha-amidated residue" EXACT PSI-MOD-alternate []
synonym: "Amidated" RELATED PSI-MS-label []
synonym: "Amidation" RELATED Unimod-description []
synonym: "Amide formation (C terminus)" EXACT DeltaMass-label []
synonym: "ctermamide" EXACT OMSSA-label []
synonym: "ResN" EXACT PSI-MOD-label []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:2"
is_a: MOD:00674 ! amidated residue

[Term]
id: MOD:00884
name: S-aminoethylcysteine (Cys)
def: "A protein modification that effectively converts an L-cysteine residue to S-2-aminoethylcysteine." [PubMed:1175632, PubMed:18688235]
comment: This modified residue is a chemical isolog of L-lysine for trypsin hydolysis produced from L-cysteine by aziridine.
subset: PSI-MOD-slim
synonym: "4-thialysine" EXACT PSI-MOD-alternate []
synonym: "L-cysteine aziridine adduct" EXACT PSI-MOD-alternate []
synonym: "S-(2-aminoethyl)-L-cysteine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "43.07"
xref: DiffFormula: "C 2 H 5 N 1 O 0 S 0"
xref: DiffMono: "43.042199"
xref: Formula: "C 5 H 10 N 2 O 1 S 1"
xref: MassAvg: "146.21"
xref: MassMono: "146.051384"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00885
name: ester crosslinked residues
def: "A protein modification that crosslinks two residues by formation of an ester bond." [PubMed:18688235]
is_a: MOD:00033 ! crosslinked residues

[Term]
id: MOD:00886
name: 6'-chloro-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to 6'-chloro-L-tryptophan." [PubMed:9033387, RESID:AA0180, Unimod:936#W]
comment: The Unimod:340 cross-reference to RESID:AA0180 is incorrect. RESID:AA0180 should be cross-referenced by Unimod:936 [JSG].
synonym: "(2S)-2-amino-3-(6-chloro-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "6'-chloro-L-tryptophan" EXACT RESID-name []
synonym: "6'-ClTrp" EXACT PSI-MOD-label []
synonym: "MOD_RES 6'-chlorotryptophan" EXACT UniProt-feature []
xref: DiffAvg: "34.44"
xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0"
xref: DiffMono: "33.961028"
xref: Formula: "C 11 Cl 1 H 9 N 2 O 1"
xref: MassAvg: "220.66"
xref: MassMono: "220.040341"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:936"
xref: uniprot.ptm:PTM-0052
is_a: MOD:01913 ! monochlorinated L-tryptophan

[Term]
id: MOD:00887
name: methylated aspartic acid
def: "A protein modification that effectively converts an L-aspartic acid residue to a methylated aspartic acid, such as aspartic acid 4-methyl ester." [PubMed:18688235]
is_a: MOD:00427 ! methylated residue
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:00888
name: protonated L-proline (L-prolinium) residue
def: "A protein modification that effectively converts an L-proline to an L-prolinium (protonated L-proline)." [PubMed:18688235]
subset: PSI-MOD-slim
xref: DiffAvg: "1.01"
xref: DiffFormula: "C 0 H 1 N 0 O 0"
xref: DiffMono: "1.007276"
xref: FormalCharge: "1+"
xref: Formula: "C 5 H 9 N 1 O 1"
xref: MassAvg: "99.13"
xref: MassMono: "99.067865"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00915 ! modified L-proline residue
is_a: MOD:01700 ! alpha-amino protonated residue

[Term]
id: MOD:00889
name: N,N-dimethyl-L-proline (from L-prolinium)
def: "A protein modification that effectively converts an L-prolinium (charged L-proline) residue to N,N-dimethyl-L-proline." [Unimod:36#P]
subset: PSI-MOD-slim
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4 N 0 O 0"
xref: DiffMono: "28.030752"
xref: FormalCharge: "1+"
xref: Formula: "C 7 H 13 N 1 O 1"
xref: MassAvg: "127.19"
xref: MassMono: "127.099165"
xref: Origin: "MOD:00888"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:36"
relationship: derives_from MOD:00075 ! N,N-dimethyl-L-proline
relationship: derives_from MOD:00888 ! protonated L-proline (L-prolinium) residue
is_a: MOD:00712 ! methylated proline
is_a: MOD:00710 ! protonated-dimethylated residue
is_a: MOD:01686 ! alpha-amino dimethylated residue

[Term]
id: MOD:00890
name: phosphorylated L-histidine
def: "A protein modification that effectively converts an L-histidine residue to a phosphorylated L-histidine, such as pros-phosphohistidine, or tele-phosphohistidine." [OMSSA:192, Unimod:21#H]
subset: PSI-MOD-slim
synonym: "mod192" EXACT OMSSA-label []
synonym: "NPhosHis" EXACT PSI-MOD-label []
synonym: "Phospho" RELATED PSI-MS-label []
synonym: "phosphohistidine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "79.98"
xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "C 6 H 8 N 3 O 4 P 1"
xref: MassAvg: "217.12"
xref: MassMono: "217.025242"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:21"
xref: uniprot.ptm:PTM-0252
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01456 ! N-phosphorylated residue

[Term]
id: MOD:00891
name: D-serine
def: "A protein modification that effectively converts a source amino acid residue to D-serine." [ChEBI:29998, PubMed:6893271, PubMed:7973665, RESID:AA0195]
synonym: "(R)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic []
synonym: "D-Ser" EXACT PSI-MOD-label []
synonym: "D-serine" EXACT RESID-name []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 3 H 5 N 1 O 2"
xref: MassAvg: "87.08"
xref: MassMono: "87.032028"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:00892
name: D-serine (Cys)
def: "A protein modification that effectively converts an L-cysteine residue to D-serine." [PubMed:18025465, PubMed:6893271, RESID:AA0195#CYS]
synonym: "(R)-2-amino-3-hydroxypropanoic acid" EXACT RESID-systematic []
synonym: "D-serine" EXACT RESID-name []
synonym: "MOD_RES D-serine (Cys)" EXACT UniProt-feature []
xref: DiffAvg: "-16.06"
xref: DiffFormula: "C 0 H 0 N 0 O 1 S -1"
xref: DiffMono: "-15.977156"
xref: Formula: "C 3 H 5 N 1 O 2"
xref: MassAvg: "87.08"
xref: MassMono: "87.032028"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0309
is_a: MOD:00891 ! D-serine
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00893
name: residues isobaric at 128.0-128.1
def: "Natural or modified residues with a mass of 128.0-128.1 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00616 ! residues isobaric at a resolution below 0.1 Da

[Term]
id: MOD:00894
name: residues isobaric at 128.058578 Da
def: "Natural or modified resiues with a mass of 128.058578 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00569 ! residues isobaric at a resolution below 0.000001 Da
is_a: MOD:00893 ! residues isobaric at 128.0-128.1

[Term]
id: MOD:00895
name: FAD modified residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a flavin adenine dinucleotide (FAD) group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "FADRes" EXACT PSI-MOD-label []
xref: DiffAvg: "783.54"
xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2"
xref: DiffMono: "783.141485"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00697 ! flavin modified residue
is_a: MOD:00861 ! phosphorus containing modified residue

[Term]
id: MOD:00896
name: FMN modified residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "FMNRes" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00697 ! flavin modified residue
is_a: MOD:00861 ! phosphorus containing modified residue

[Term]
id: MOD:00897
name: N-acetyl-S-archeol-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to N-acetyl-S-archeol-L-cysteine." [RESID:AA0043#var, RESID:AA0223#var]
xref: DiffAvg: "677.20"
xref: DiffFormula: "C 45 H 88 N 0 O 3 S 0"
xref: DiffMono: "676.673347"
xref: Formula: "C 48 H 93 N 1 O 4 S 1"
xref: MassAvg: "780.34"
xref: MassMono: "779.682531"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00905 ! modified L-cysteine residue
relationship: has_functional_parent MOD:00052 ! N-acetyl-L-cysteine
relationship: has_functional_parent MOD:00228 ! S-diphytanylglycerol diether-L-cysteine

[Term]
id: MOD:00898
name: S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine." [PubMed:10896212, PubMed:4575979, PubMed:9056182, RESID:AA0107#var, Unimod:377]
comment: Incidental to RESID:AA0060.
synonym: "Diacylglycerol" RELATED PSI-MS-label []
synonym: "diacylglycerol" RELATED Unimod-description []
xref: DiffAvg: "576.95"
xref: DiffFormula: "C 37 H 68 N 0 O 4 S 0"
xref: DiffMono: "576.511761"
xref: Formula: "C 40 H 73 N 1 O 5 S 1"
xref: MassAvg: "680.09"
xref: MassMono: "679.520945"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:377"
is_a: MOD:00116 ! S-diacylglycerol-L-cysteine

[Term]
id: MOD:00899
name: N-palmitoyl-S-diacylglycerol-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-diacylglycerol-L-cysteine." [RESID:AA0069#var, RESID:AA0107#var]
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00905 ! modified L-cysteine residue
relationship: has_functional_parent MOD:00069 ! N-palmitoyl-L-cysteine
relationship: has_functional_parent MOD:00116 ! S-diacylglycerol-L-cysteine

[Term]
id: MOD:00900
name: N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine
def: "A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine." [PubMed:18688235]
synonym: "(R)-2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid" EXACT PSI-MOD-alternate []
synonym: "2-hexadecanoylamino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid" EXACT PSI-MOD-alternate []
xref: DiffAvg: "815.36"
xref: DiffFormula: "C 53 H 98 N 0 O 5 S 0"
xref: DiffMono: "814.741426"
xref: Formula: "C 56 H 103 N 1 O 6 S 1"
xref: MassAvg: "918.50"
xref: MassMono: "917.750611"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00899 ! N-palmitoyl-S-diacylglycerol-L-cysteine
relationship: has_functional_parent MOD:00069 ! N-palmitoyl-L-cysteine
relationship: has_functional_parent MOD:00898 ! S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine

[Term]
id: MOD:00901
name: modified L-alanine residue
def: "A protein modification that modifies an L-alanine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModAla" EXACT PSI-MOD-label []
xref: Origin: "A"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00902
name: modified L-arginine residue
def: "A protein modification that modifies an L-arginine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModArg" EXACT PSI-MOD-label []
xref: Origin: "R"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00903
name: modified L-asparagine residue
def: "A protein modification that modifies an L-asparagine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModAsn" EXACT PSI-MOD-label []
xref: Origin: "N"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00904
name: modified L-aspartic acid residue
def: "A protein modification that modifies an L-aspartic acid residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModAsp" EXACT PSI-MOD-label []
xref: Origin: "D"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00905
name: modified L-cysteine residue
def: "A protein modification that modifies an L-cysteine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModCys" EXACT PSI-MOD-label []
xref: Origin: "C"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00906
name: modified L-glutamic acid residue
def: "A protein modification that modifies an L-glutamic acid residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModGlu" EXACT PSI-MOD-label []
xref: Origin: "E"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00907
name: modified L-glutamine residue
def: "A protein modification that modifies an L-glutamine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModGln" EXACT PSI-MOD-label []
xref: Origin: "Q"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00908
name: modified glycine residue
def: "A protein modification that modifies a glycine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModGly" EXACT PSI-MOD-label []
xref: Origin: "G"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00909
name: modified L-histidine residue
def: "A protein modification that modifies an L-histidine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModHis" EXACT PSI-MOD-label []
xref: Origin: "H"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00910
name: modified L-isoleucine residue
def: "A protein modification that modifies an L-isoleucine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModIle" EXACT PSI-MOD-label []
xref: Origin: "I"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00911
name: modified L-leucine residue
def: "A protein modification that modifies an L-leucine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModLeu" EXACT PSI-MOD-label []
xref: Origin: "L"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00912
name: modified L-lysine residue
def: "A protein modification that modifies an L-lysine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModLys" EXACT PSI-MOD-label []
xref: Origin: "K"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00913
name: modified L-methionine residue
def: "A protein modification that modifies an L-methionine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModMet" EXACT PSI-MOD-label []
xref: Origin: "M"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00914
name: modified L-phenylalanine residue
def: "A protein modification that modifies an L-phenylalanine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModPhe" EXACT PSI-MOD-label []
xref: Origin: "F"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00915
name: modified L-proline residue
def: "A protein modification that modifies an L-proline residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModPro" EXACT PSI-MOD-label []
xref: Origin: "P"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00916
name: modified L-serine residue
def: "A protein modification that modifies an L-serine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModSer" EXACT PSI-MOD-label []
xref: Origin: "S"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00917
name: modified L-threonine residue
def: "A protein modification that modifies an L-threonine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModThr" EXACT PSI-MOD-label []
xref: Origin: "T"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00918
name: modified L-tryptophan residue
def: "A protein modification that modifies an L-tryptophan residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModTrp" EXACT PSI-MOD-label []
xref: Origin: "W"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00919
name: modified L-tyrosine residue
def: "A protein modification that modifies an L-tyrosine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModTyr" EXACT PSI-MOD-label []
xref: Origin: "Y"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00920
name: modified L-valine residue
def: "A protein modification that modifies an L-valine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModVal" EXACT PSI-MOD-label []
xref: Origin: "V"
is_a: MOD:01157 ! protein modification categorized by amino acid modified

[Term]
id: MOD:00921
name: new uncategorized Unimod entries
def: "New uncategorized Unimod. OBSOLETE because organizational use is no longer required." [PubMed:18688235]
is_obsolete: true

[Term]
id: MOD:00922
name: Cy3 CyDye DIGE Fluor saturation dye
def: "modification from Unimod Chemical derivative" [Unimod:494]
synonym: "Cy3 CyDye DIGE Fluor saturation dye" RELATED Unimod-description []
synonym: "CyDye-Cy3" RELATED Unimod-interim []
xref: DiffAvg: "672.84"
xref: DiffFormula: "C 37 H 44 N 4 O 6 S 1"
xref: DiffMono: "672.298156"
xref: Formula: "C 40 H 49 N 5 O 7 S 2"
xref: MassAvg: "775.98"
xref: MassMono: "775.307341"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:494"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00923
name: Cy5 CyDye DIGE Fluor saturation dye
def: "modification from Unimod Chemical derivative" [Unimod:495]
synonym: "Cy5 CyDye DIGE Fluor saturation dye" RELATED Unimod-description []
synonym: "CyDye-Cy5" RELATED Unimod-interim []
xref: DiffAvg: "684.85"
xref: DiffFormula: "C 38 H 44 N 4 O 6 S 1"
xref: DiffMono: "684.298156"
xref: Formula: "C 41 H 49 N 5 O 7 S 2"
xref: MassAvg: "787.99"
xref: MassMono: "787.307341"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:495"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00924
name: N6-(L-threonyl)-L-lysine
def: "A protein modification that effectively crosslinks an L-lysine residue and an L-threonine residue by an isopeptide bond to form N6-(L-threonyl)-L-lysine." [PubMed:18063774, RESID:AA0440]
comment: Cross-link 2.
synonym: "(2S)-2-amino-6-([(2S,3R)-2-amino-3-hydroxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "N6-(L-threonyl)-L-lysine" EXACT RESID-name []
synonym: "N6-threonyl-lysine" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 10 H 18 N 3 O 3"
xref: MassAvg: "228.27"
xref: MassMono: "228.134816"
xref: Origin: "K, T"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0326
is_a: MOD:00688 ! isopeptide crosslinked residues
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:00925
name: heptosylated residue
def: "A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a heptose sugar group through a glycosidic bond." [Unimod:490]
comment: From Unimod with no citation [JSG].
synonym: "Hep" RELATED PSI-MS-label []
synonym: "Heptose" RELATED Unimod-description []
xref: DiffAvg: "192.17"
xref: DiffFormula: "C 7 H 12 O 6"
xref: DiffMono: "192.063388"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:490"
is_a: MOD:00693 ! glycosylated residue

[Term]
id: MOD:00926
name: Bisphenol A diglycidyl ether derivative
def: "Modification from Unimod Non-standard residue. OBSOLETE because not an amino acid modification. From Unimod not an approved entry." [PubMed:11225353, Unimod:493]
synonym: "BADGE" RELATED Unimod-interim []
synonym: "Bisphenol A diglycidyl ether derivative" RELATED Unimod-description []
xref: DiffAvg: "340.42"
xref: DiffFormula: "C 21 H 24 O 4"
xref: DiffMono: "340.167459"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:493"
is_obsolete: true

[Term]
id: MOD:00927
name: 2x(13)C,4x(2)H labeled dimethylated residue
def: "A protein modification that effectively replaces two hydrogen atoms of a residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated residue." [PubMed:16335955, PubMed:3802193, Unimod:510]
synonym: "DiMethyl-C13HD2" RELATED Unimod-description []
synonym: "Dimethyl:2H(4)13C(2)" RELATED PSI-MS-label []
xref: DiffAvg: "34.06"
xref: DiffFormula: "(13)C 2 (2)H 4"
xref: DiffMono: "34.063117"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:510"
is_a: MOD:00839 ! (2)H deuterium labeled residue
is_a: MOD:00842 ! (13)C labeled residue

[Term]
id: MOD:00928
name: [3-(2,5)-dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium
def: "modification from Unimod Chemical derivative" [PubMed:16771548, Unimod:513]
comment: Should have children for K and X-N-term [JSG].
synonym: "[3-(2,5)-Dioxopyrrolidin-1-yloxycarbonyl)-propyl]dimethyloctylammonium" RELATED Unimod-description []
synonym: "C8-QAT" RELATED Unimod-interim []
xref: DiffAvg: "227.39"
xref: DiffFormula: "C 14 H 29 N 1 O 1"
xref: DiffMono: "227.224915"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:513"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00929
name: lactose glycated lysine
def: "A modification produced in a non-enzymatic reaction between a lactose carbonyl group and an L-lysine to form a Schiff-base or an Amadori ketosamine lysine adduct." [PubMed:9606156, Unimod:512]
comment: The term lactosylation used with this meaning is a misnomer [JSG].
synonym: "Hex(2)" RELATED Unimod-interim []
synonym: "Lactosylation" RELATED Unimod-description []
synonym: "CARBOHYD N-linked (Lac) (glycation) lysine" EXACT UniProt-feature []
xref: DiffAvg: "342.30"
xref: DiffFormula: "C 12 H 22 O 11"
xref: DiffMono: "342.116212"
xref: Formula: "C 18 H 34 N 2 O 12"
xref: MassAvg: "470.47"
xref: MassMono: "470.211175"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:512"
xref: uniprot.ptm:PTM-0511
is_a: MOD:00767 ! glycated residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00930
name: propyl-NAG tyrosine adduct
def: "tyrosine adduct with substrate analog inhibitor 1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-Delta2'-thiazoline." [PubMed:15795231, Unimod:514]
xref: DiffAvg: "232.27"
xref: DiffFormula: "C 9 H 14 N 1 O 4 S 1"
xref: DiffMono: "232.064354"
xref: Formula: "C 18 H 23 N 2 O 6 S 1"
xref: MassAvg: "395.45"
xref: MassMono: "395.127682"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:514"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00931
name: Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K
def: "modification from Unimod Other - BHTOH is formed upon metabolism of BHT with P450 enzymes. The BHTOH is further metabolized to its quinone methide (electrophile) which reacts with -SH and -NH2 groups" [PubMed:11085420, Unimod:498]
synonym: "BHTOH" RELATED Unimod-interim []
synonym: "Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K" RELATED Unimod-description []
xref: DiffAvg: "234.34"
xref: DiffFormula: "C 15 H 22 O 2"
xref: DiffMono: "234.161980"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:498"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00932
name: IDBEST tag for quantitation
def: "modification from Unimod Isotopic label" [PubMed:11821862, Unimod:499]
synonym: "Heavy IDBEST tag for quantitation" RELATED Unimod-description []
synonym: "IGBP:13C(2)" RELATED PSI-MS-label []
xref: DiffAvg: "298.02"
xref: DiffFormula: "Br 1 (12)C 10 (13)C 2 H 13 N 2 O 2"
xref: DiffMono: "298.022749"
xref: Formula: "Br 1 (12)C 13 (13)C 2 H 18 N 3 O 3 S 1"
xref: MassAvg: "401.03"
xref: MassMono: "401.031934"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:499"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01428 ! (13)C isotope tagged reagent

[Term]
id: MOD:00933
name: methylglyoxal arginine adduct (+54 amu)
def: "modification from Unimod Chemical derivative - 5-hydro-5-methylimidazol-4-one, arginine methylglyoxal arginine adduct (+54 amu)" [Unimod:319#R]
comment: Ref. Uchida K, Sakai K, Itakura K, Osawa T, Toyokuni S. 1977. Protein modification by lipid peroxidation products: formation of malondialdehyde-derived N(epsilon)-(2-propenol)lysine in proteins. Arch Biochem Biophys. 346(1):45-52.
synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label []
synonym: "MDA adduct +54" RELATED Unimod-description []
xref: DiffAvg: "54.05"
xref: DiffFormula: "C 3 H 2 O 1"
xref: DiffMono: "54.010565"
xref: Formula: "C 9 H 14 N 4 O 2"
xref: MassAvg: "210.24"
xref: MassMono: "210.111676"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:319"
is_a: MOD:00630 ! C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine.
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00934
name: Levuglandinyl - arginine hydroxylactam adduct
def: "modification from Unimod Post-translational" [Unimod:506]
synonym: "Levuglandinyl - arginine hydroxylactam adduct" RELATED Unimod-description []
synonym: "LG-Hlactam-R" RELATED Unimod-interim []
xref: DiffAvg: "306.40"
xref: DiffFormula: "C 19 H 26 N -2 O 5"
xref: DiffMono: "306.171876"
xref: Formula: "C 25 H 38 N 2 O 6"
xref: MassAvg: "462.59"
xref: MassMono: "462.272987"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:506"
is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00935
name: methionine oxidation with neutral loss of 64 Da
def: "Oxidation of methionine to methionine sulfoxide with neutral loss of CH3SOH." [PubMed:18688235, PubMed:9004526]
comment: Originally created from Unimod:507 that was later deleted.
xref: DiffAvg: "-64.10"
xref: DiffFormula: "C -1 H -4 N 0 O -1 S -1"
xref: DiffMono: "-63.998286"
xref: Formula: "C 4 H 5 N 1 O 1 S 0"
xref: MassAvg: "83.09"
xref: MassMono: "83.037114"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00431 ! modified residue with a secondary neutral loss
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:00936
name: Levuglandinyl - hydroxylactam adduct, K and N-term
def: "modification from Unimod Post-translational" [Unimod:504]
synonym: "Levuglandinyl - lysine hydroxylactam adduct" RELATED Unimod-description []
synonym: "LG-Hlactam-K" RELATED Unimod-interim []
xref: DiffAvg: "348.44"
xref: DiffFormula: "C 20 H 28 O 5"
xref: DiffMono: "348.193674"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:504"
is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct

[Term]
id: MOD:00937
name: Levuglandinyl - arginine lactam adduct
def: "modification from Unimod Post-translational" [Unimod:505]
synonym: "Levuglandinyl - arginine lactam adduct" RELATED Unimod-description []
synonym: "LG-lactam-R" RELATED Unimod-interim []
xref: DiffAvg: "290.40"
xref: DiffFormula: "C 19 H 26 N -2 O 4"
xref: DiffMono: "290.176961"
xref: Formula: "C 25 H 38 N 2 O 5"
xref: MassAvg: "446.59"
xref: MassMono: "446.278072"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:505"
is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:00938
name: Levuglandinyl - lactam adduct, K and N-term
def: "modification from Unimod Post-translational" [PubMed:12590383, Unimod:503]
synonym: "Levuglandinyl - lysine lactam adduct" RELATED Unimod-description []
synonym: "LG-lactam-K" RELATED Unimod-interim []
xref: DiffAvg: "332.44"
xref: DiffFormula: "C 20 H 28 O 4"
xref: DiffMono: "332.198759"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:503"
is_a: MOD:00846 ! levuglandinyl (prostaglandin H2) adduct

[Term]
id: MOD:00939
name: hydrolyzed N-methylmaleimide cysteine adduct
def: "modification from Unimod Chemical derivative" [Unimod:500]
synonym: "Nmethylmaleimide+water" RELATED Unimod-interim []
synonym: "Nmethylmaleimidehydrolysis" RELATED Unimod-description []
xref: DiffAvg: "129.12"
xref: DiffFormula: "C 5 H 7 N 1 O 3"
xref: DiffMono: "129.042593"
xref: Formula: "C 8 H 12 N 2 O 4 S 1"
xref: MassAvg: "232.25"
xref: MassMono: "232.051778"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:500"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00940
name: 3-methyl-2-pyridyl isocyanate derivatized residue
def: "A protein modification produced by formation of an adduct with 3-methyl-2-pyridyl isocyanate." [PubMed:11078590, Unimod:501]
synonym: "3-methyl-2-pyridyl isocyanate" RELATED Unimod-description []
synonym: "PyMIC" RELATED Unimod-interim []
xref: DiffAvg: "134.14"
xref: DiffFormula: "C 7 H 6 N 2 O 1"
xref: DiffMono: "134.048013"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:501"
is_a: MOD:00840 ! isocyanate reagent derivatized residue

[Term]
id: MOD:00941
name: dehydropyrrolizidine alkaloid (dehydroretronecine) derivatized cysteine
def: "modification from Unimod Chemical derivative" [PubMed:12175151, Unimod:488]
synonym: "Dehydropyrrolizidine alkaloid (dehydroretronecine) on cysteines" RELATED Unimod-description []
synonym: "DHP" RELATED Unimod-interim []
xref: DiffAvg: "118.16"
xref: DiffFormula: "C 8 H 8 N 1"
xref: DiffMono: "118.065674"
xref: Formula: "C 11 H 13 N 2 S 1"
xref: MassAvg: "205.30"
xref: MassMono: "205.079944"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:488"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00942
name: (4,4,5,5-(2)H4)-L-lysine
def: "A protein modification that effectively substitutes four (1)H protium atoms with four (2)H deuterium atoms to produce (4,4,5,5-(2)H4)-L-lysine." [OMSSA:180, Unimod:481]
comment: For SILAC experiments.
synonym: "4,4,5,5-D4 Lysine" RELATED Unimod-description []
synonym: "4,4,5,5-tetradeuterolysine" EXACT PSI-MOD-alternate []
synonym: "Label:2H(4)" RELATED Unimod-interim []
synonym: "lys-2H4" EXACT OMSSA-label []
xref: DiffAvg: "4.03"
xref: DiffFormula: "(1)H -4 (2)H 4"
xref: DiffMono: "4.025107"
xref: Formula: "C 6 (1)H 8 (2)H 4 N 2 O 1"
xref: MassAvg: "132.12"
xref: MassMono: "132.120070"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:481"
is_a: MOD:00837 ! deuterium tetrasubstituted residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:00943
name: 4-trimethylammoniumbutanoyl derivatized residue
def: "modification from Unimod Isotopic label" [PubMed:12643539, Unimod:476]
synonym: "4-trimethyllammoniumbutyryl-" RELATED Unimod-description []
synonym: "TMAB" RELATED Unimod-interim []
xref: DiffAvg: "128.19"
xref: DiffFormula: "C 7 H 14 N 1 O 1"
xref: DiffMono: "128.107539"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:476"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00944
name: d9-4-trimethylammoniumbutanoyl derivatized residue
def: "modification from Unimod Isotopic label" [Unimod:477]
synonym: "d9-4-trimethyllammoniumbutyryl-" RELATED Unimod-description []
synonym: "TMAB:2H(9)" RELATED Unimod-interim []
xref: DiffAvg: "137.16"
xref: DiffFormula: "C 7 (1)H 5 (2)H 9 N 1 O 1"
xref: DiffMono: "137.164030"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:477"
relationship: derives_from MOD:00943 ! 4-trimethylammoniumbutanoyl derivatized residue
is_a: MOD:01431 ! (2)H deuterium tagged reagent

[Term]
id: MOD:00945
name: fluorescein-5-thiosemicarbazide adduct
def: "OBSOLETE because redundant and identical to MOD:00626. Remap to MOD:00626." [PubMed:18688235]
xref: DiffAvg: "421.43"
xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1"
xref: DiffMono: "421.073242"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00626"
is_obsolete: true

[Term]
id: MOD:00946
name: crosslinked residues with loss of ammonia
def: "A protein modification that crosslinks two residues with a covalent bond and the loss of ammonia." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00033 ! crosslinked residues

[Term]
id: MOD:00947
name: DeltaMass
def: "Entries from DeltaMass see http://www.abrf.org/index.cfm/dm.home?AvgMass=all." [PubMed:18688235]
is_a: MOD:00032 ! uncategorized protein modification

[Term]
id: MOD:00948
name: 5'-dephospho
def: "OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: -79
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:00949
name: desmosine
def: "OBSOLETE because redundant and identical to MOD:01933. Remap to MOD:01933." [DeltaMass:0]
comment: From DeltaMass: Average Mass: -58
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "K"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:01933"
is_obsolete: true

[Term]
id: MOD:00950
name: decomposed carboxymethylated methionine
def: "OBSOLETE because this modification has not been seen/reported on since this original publication in 1994 and carboxymethylation of proteins is common enough for this mass shift to have been seen in the intervening 25+ years. modification from DeltaMass" [DeltaMass:3]
comment: From DeltaMass: Average Mass: -48 Average Mass Change:-48 References:Anal. Biochem. Vol 216 No.1 p141
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "M"
xref: Source: "none"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:00951
name: L-gamma-carboxyglutamic acid with neutral loss of carbon dioxide
def: "Covalent modification of a peptide or protein L-glutamic acid residue to gamma-carboxyglutamic acid with secondary loss of a neutral carbon dioxide molecular fragment." [DeltaMass:58]
comment: From DeltaMass: Average Mass: -44 Formula:CO2 Average Mass Change:-44 References:Nakamura T, Yu Z, Fainzilber M, Burlingame AL. Protein Sci (1996) 5, 524-530 Mass spectrometric-based revision of the structure of a cysteine-rich peptide toxin with gamma-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile. Notes: The elimination of CO2 will regenerate glutamate as if there was no modification. However, peaks appearing with an interval of 44 is quite characteristic. It would be noteworthy to remind that loss of 44 from a gamma-carboxyglutamate-containing peptide may be observed not only as a result of spontaneous decarboxylation but also as an artifact under some ionization conditions such as negative ion mode MALDI.
synonym: "d4CbxGlu" EXACT PSI-MOD-label []
xref: DiffAvg: "-44.01"
xref: DiffFormula: "C -1 H 0 N 0 O -2"
xref: DiffMono: "-43.989829"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00906 ! modified L-glutamic acid residue
is_a: MOD:00957 ! modified residue with neutral loss of carbon dioxide
is_a: MOD:00960 ! decarboxylated residue

[Term]
id: MOD:00952
name: (2-aminosuccinimidyl)acetic acid (Asp)
def: "A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the loss of a water molecule." [PubMed:10801322, RESID:AA0441#ASP]
comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue with the alpha-amido of the following residue.
subset: PSI-MOD-slim
synonym: "(2-aminosuccinimidyl)acetic acid" EXACT RESID-name []
synonym: "(3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid" EXACT RESID-alternate []
synonym: "[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid" EXACT RESID-systematic []
synonym: "anhydroaspartyl glycine" EXACT RESID-alternate []
synonym: "aspartimide glycine" EXACT RESID-alternate []
synonym: "CROSSLNK (2-aminosuccinimidyl)acetic acid (Asp-Gly)" EXACT UniProt-feature []
synonym: "N-(2-aminosuccinyl)glycine" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 6 H 6 N 2 O 3"
xref: MassAvg: "154.13"
xref: MassMono: "154.037842"
xref: Origin: "D, G"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0312
is_a: MOD:02043 ! crosslinked L-aspartic acid residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01628 ! (2-aminosuccinimidyl)acetic acid

[Term]
id: MOD:00953
name: O-(L-isoglutamyl)-L-serine (Glu-Ser)
def: "A protein modification that effectively crosslinks an L-glutamic acid residue and an L-serine residue by an ester bond and releasing water to form O-(L-isoglutamyl)-L-serine." [DeltaMass:0, PubMed:19035375, RESID:AA0597#ESX]
comment: Cross-link 2; From DeltaMass: with no citation.
synonym: "(2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "CROSSLNK isoglutamyl serine ester (Ser-Glu)" EXACT UniProt-feature []
synonym: "O(beta)-(gamma-glutamyl)serine" EXACT RESID-alternate []
synonym: "O-(L-isoglutamyl)-L-serine" EXACT RESID-name []
synonym: "O-gamma-Glutamyl- (Crosslink to Serine)" EXACT DeltaMass-label []
synonym: "O3-(isoglutamyl)-serine" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 8 H 10 N 2 O 4"
xref: MassAvg: "198.18"
xref: MassMono: "198.064057"
xref: Origin: "E, S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02045 ! crosslinked L-glutamic acid residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01977 ! O-(L-isoglutamyl)-L-serine

[Term]
id: MOD:00954
name: crosslinked residues with loss of water
def: "A protein modification that crosslinks two residues with a covalent bond and the loss of water." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00033 ! crosslinked residues

[Term]
id: MOD:00955
name: alaninohistidine (serine crosslinked to tele or pros nitrogen of histidine)
def: "A protein modification that effectively crosslinks an L-serine residue and an L-histidine residue to release water and form tele- or pros-(2-amino-2-carboxyethyl)histidine." [DeltaMass:0]
comment: Cross-link 2; From DeltaMass with no citation or formula: Average Mass: -18. The DeltaMass description "Serine crosslinked to theta or pi carbon of Histidine" is incorrect. The histidine ring nitrogens (not carbons) are designated tele or N-tau (not theta), and pros or N-pi [JSG].
synonym: "beta-alaninohistidine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 9 H 10 N 4 O 2"
xref: MassAvg: "206.20"
xref: MassMono: "206.080376"
xref: Origin: "H, S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02048 ! crosslinked L-histidine residue
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:00956
name: misincorporation of norleucine for methionine
def: "modification from DeltaMass" [DeltaMass:10]
comment: From DeltaMass: Average Mass: -18 Average Mass Change:-18 Notes: It has the same mass as leucine or isoleucine and can be charged on the methionyl t-RNA. This often happens in minimal media-prepared fermentations that are not supplemented with enough free methionine. It gives a mass change of -18 and can often be confused with dehydration.
xref: DiffAvg: "-18.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0 S -1"
xref: DiffMono: "-17.956421"
xref: Formula: "C 6 H 11 N 1 O 1"
xref: MassAvg: "113.16"
xref: MassMono: "113.084064"
xref: Origin: "M"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:01026 ! norleucine residue (Nle)

[Term]
id: MOD:00957
name: modified residue with neutral loss of carbon dioxide
def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral carbon dioxide molecular fragment." [PubMed:18688235]
synonym: "dCO2ModRes" EXACT PSI-MOD-label []
xref: DiffAvg: "-44.01"
xref: DiffFormula: "C -1 H 0 N 0 O -2"
xref: DiffMono: "-43.989829"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00431 ! modified residue with a secondary neutral loss

[Term]
id: MOD:00958
name: crosslink between Arg and His sidechains
def: "modification from DeltaMass" [DeltaMass:0]
comment: Cross-link 2; From DeltaMass: Average Mass: -5
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "H, R"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00692 ! uncategorized crosslinked residues

[Term]
id: MOD:00959
name: 3,3',5,5'-TerTyr (Crosslink)
def: "modification from DeltaMass" [DeltaMass:0]
comment: Cross-link 4; From DeltaMass: Average Mass: -4
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "Y, Y, Y, Y"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00692 ! uncategorized crosslinked residues

[Term]
id: MOD:00960
name: decarboxylated residue
def: "A protein modification that effectively replaces a carboxylic acid group with a hydrogen atom." [PubMed:18688235]
xref: DiffAvg: "-44.01"
xref: DiffFormula: "C -1 H 0 N 0 O -2"
xref: DiffMono: "-43.989829"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:00961
name: reduction of disulfide crosslink in cystine to two cysteines
def: "A protein modification that effectively reduces the disulfide bond of cystine to form two cysteine residues." [DeltaMass:333]
comment: Cross-link 2; this modification destroys the cross-link. From DeltaMass: Treatment of cystine (cys-cys) by reducing agents such as dithiothreitol (DTT) or triscarboxyethylphosphine (TCEP) results in cleavage of the disulphide bond and reduction of the sulphur atom of each molecule to create cysteine.
subset: PSI-MOD-slim
xref: DiffAvg: "2.02"
xref: DiffFormula: "C 0 H 2 N 0 O 0 S 0"
xref: DiffMono: "2.015650"
xref: Formula: "C 6 H 10 N 2 O 2 S 2"
xref: MassAvg: "206.28"
xref: MassMono: "206.018370"
xref: Origin: "MOD:00034"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01473 ! hydrogenated residue
relationship: derives_from MOD:00034 ! L-cystine (cross-link)

[Term]
id: MOD:00962
name: 2',3'-dihydrotryptophan
def: "A protein modification that by reducing the indole ring system of tryptophan to indoline effectively converts an L-tryptophan residue to 2',3'-dihydrotryptophan." [DeltaMass:343, URL:http\://dx.doi.org/10.1016/S0040-4039(00)99113-5]
comment: From DeltaMass: References:1. Pearson,D.A., Blanchette,M., Baker,M.L. and Guindon,C.A. (1989) Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking ofprotecting groups in peptide synthesis. Tetrahedron Lett., 30(21), 2739-2742 Notes: Reduction of indole double bond of Trp which occurs when triethylsilane (TES) is used as a scavenger and Trp is incorporated without protection of indole nitrogen [1]. This side reaction is likely to be accompanied by oxidation of indoline ring with formation of intensively colored peptide by-products. Triisopropylsilane (TIPS) does not give this side reaction. See structure at http://www.abrf.org/images/misc/dmass2.gif. [However, the pictured indoline structure is incorrect - JSG].
xref: DiffAvg: "2.02"
xref: DiffFormula: "C 0 H 2 N 0 O 0 S 0"
xref: DiffMono: "2.015650"
xref: Formula: "C 11 H 12 N 2 O 1"
xref: MassAvg: "188.23"
xref: MassMono: "188.094963"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00918 ! modified L-tryptophan residue
is_a: MOD:01473 ! hydrogenated residue

[Term]
id: MOD:00963
name: Oxidation of Trp to kynurenine
def: "Modification from DeltaMass. OBSOLETE because redundant and identical to MOD:00462. Remap to MOD:00462." [DeltaMass:357]
comment: From DeltaMass: Average Mass: 4 Monoisotopic Mass Change:3.995 Average Mass Change:3.989 References:Ruoppolo M, Amoresano A, Pucci P, Pascarella S, Polticelli F, Trovato M,Menegatti E, Ascenzi P.Characterization of five new low-molecular-mass trypsin inhibitors fromwhite mustard (Sinapis alba L.) seed.Eur J Biochem. 2000 267:6486-92. Notes: See structure at http://www.abrf.org/images/misc/dmass32.jpg.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00462"
is_obsolete: true

[Term]
id: MOD:00964
name: lysine epsilon amino to imine + 12 amu
def: "modification from DeltaMass" [DeltaMass:34]
comment: From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Mathews, W. Rodney; Runge, Thomas A.; Haroldsen, Peter E.; Gaskell, Simon J. (1989) Characterization of impurities in a synthetic renin substrate peptide by fast-atom bombardment mass spectrometry and hybrid tandem mass spectrometry. Rapid Commun. Mass Spectrom. 3(9), 314-19 Notes: Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side products, including a component 12 Da higher in mass. Low-energy collisionally activated ***decompn*** analyses were performed using a hybrid tandem instrument and demonstrated that the heavier side product had two components, in which the structural modification was either at the N- or the C-terminus. Addnl. analyses of the N-acetyl deriv. indicated that for each component the structural modification blocked a site of N-acetylation. It is suggested that the formation of these side products is attributable to the generation of formaldehyde, during removal of the histidine protecting group (benzyloxymethyl), which reacts with the N-terminus of the peptide to give an imidazolidinone structure or with the D- ***lysine***.epsilon.-amine group to yield an ***imine*** . While the precise genesis of the side-products remains speculative, it is clear that the combined strategy of derivatization and tandem mass spectrometry has allowed structural conclusions concerning individual components of an isobaric mixt.
synonym: "N6-(methylidene)-lysine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "12.01"
xref: DiffFormula: "C 1 H 0 N 0 O 0"
xref: DiffMono: "12.000000"
xref: Formula: "C 7 H 12 N 2 O 1"
xref: MassAvg: "140.19"
xref: MassMono: "140.094963"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:00965
name: 4-thiazolidinecarboxylic acid
def: "A protein modification that effectively converts an N-terminal L-cysteine residue by a formadehyde adduct to 4-thiazolidinecarboxylic acid." [DeltaMass:342]
comment: From DeltaMass: References: Mitchell, M.A., Runge, T.A., Mathews, W.R., Ichhpurani, A.K., Harn, N.K., Dobrowolski, P.J. and Eckenrrrode, F.M. Problems associated with use of the benzylozymethyl protecting group for histidines. Formaldehyde adducts formed during cleavage by hydrogen fluoride. Int. J. Pept. Protein Res. 1990, 36(4), 350-355. Gesquiere, J.-C., Diesis, E. and Tartar, A. Conversion of N-terminal cysteine to thiazolidine carboxylic acid during hydrogen fluoride deprotection of peptides containing pi-N-Bom protected histidine. J. Chem. Soc. Chem. Commun. 1990, (20), 1402-1403. Kumagaye, K.Y., Inui, T., Nakajima, K., Kimura,T. and Sakakibara, S. Suppression of a side reaction associated with Nim-benzyloxymethyl group during synthesis of peptides containing cysteinyl residue at the N-terminus. Pept. Res. 1991, 4(2), 84-87. Colombo, R., Colombo, F. and Jones, J.H. Acid-labile histidine side-chain protection. The N(pi)-t-butoxymethyl group. J. Chem. Soc. Chem. Commun. 1984, (5), 292-293. Notes: Conversion of N-term Cys to thiazolidine during HF deprotection of His(Bom)-containing peptides [1-3]. See structure at http://www.abrf.org/images/misc/dmass12b.gif; modification in red. This modification cannot be excluded during final deprotection/cleavage in Fmoc-chemistry in cases when His(Bum) was employed [4]. For formation of free imino acid see PubMed:1527501.
synonym: "thioproline" EXACT DeltaMass-label []
xref: DiffAvg: "12.01"
xref: DiffFormula: "C 1 H 0 N 0 O 0 S 0"
xref: DiffMono: "12.000000"
xref: Formula: "C 4 H 6 N 1 O 1 S 1"
xref: MassAvg: "116.16"
xref: MassMono: "116.017010"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:00966
name: 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
def: "A protein modification that effectively converts an N-terminal L-tryptophan residue by a formadehyde adduct to 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid." [DeltaMass:339]
comment: From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Lippke, K. P., W. G. Schunack, W. Wenning, W. E. Mueller. 1983..beta.-Carbolines as benzodiazepine receptor ligands. 1. Synthesis andbenzodiazepine receptor interaction of esters of.beta.-carboline-3-carboxylic acid. J. Med. Chem.26: 499-503 Cain, M., R. W. Weber, F. Guzman, J. M. Cook, S. A. Barker, K. C.Rice, J. N. Crawley, S. M. Paul, P. Skolnick. 1982. .beta.-Carbolines:synthesis and neurochemical and pharmacological actions on brainbenzodiazepine receptors.J. Med. Chem. 25: 1081-91 Notes: +12 Da modification corresponds to formaldehyde adduct of Trp having beta-carboline structure (methylene bridge links carbon-2 of indole ring and alfa-N. See structure at http://www.abrf.org/images/misc/dmass12a.gif; modification in red.
xref: DiffAvg: "12.01"
xref: DiffFormula: "C 1 H 0 N 0 O 0 S 0"
xref: DiffMono: "12.000000"
xref: Formula: "C 12 H 10 N 2 O 1"
xref: MassAvg: "198.22"
xref: MassMono: "198.079313"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:00967
name: syndesine
def: "A protein modification that effectively cross-links two L-lysine residues to form syndesine, hydroxylysinohydroxynorleucine." [DeltaMass:35, PubMed:75151974]
comment: Cross-link 2; From DeltaMass: Average Mass: 13 Average Mass Change: 13 (incorrect) [JSG].
synonym: "hydroxylysinohydroxynorleucine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "16.96"
xref: DiffFormula: "C 0 H -3 N -2 O 3"
xref: DiffMono: "16.955121"
xref: Formula: "C 12 H 21 N 2 O 5"
xref: MassAvg: "273.31"
xref: MassMono: "273.145047"
xref: Origin: "K, K"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:02051 ! crosslinked L-lysine residue

[Term]
id: MOD:00968
name: CM-Cys vs PAM-Cys
def: "OBSOLETE because this isn't a protein modification, but rather the difference between two known modifications. modification from DeltaMass" [DeltaMass:347]
comment: From DeltaMass: Average Mass: 13 Formula:C2H2O2 vs C3H5ON Monoisotopic Mass Change:13.03 Average Mass Change:13.05 Notes:Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetic acid e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxymethyl-Cys (CM-Cys, DeltaMass +58Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 13Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:00969
name: CAM-Cys vs PAM-Cys
def: "OBSOLETE because this isn't a protein modification, but rather the difference between two known modifications. modification from DeltaMass" [DeltaMass:346]
comment: From DeltaMass: Average Mass: 14 Formula:CH2 Monoisotopic Mass Change:14.016 Average Mass Change:14.027 Notes: Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetamide e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxamidomethyl-Cys (CAM-Cys, DeltaMass +57Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 14Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:00970
name: delta-hydroxy-allysine (Lys)
def: "modification from DeltaMass" [DeltaMass:37]
comment: From DeltaMass: Average Mass: 15 Average Mass Change:15 Notes:In going from Lys to hydroxy-allysine, two separate reactions are involved:1. the oxidative deamination converting Lys to allysine (-CH2NH2 being converted to -CHO) with a net mass change of -1;2.conversion of allysine to delta-hydroxy-allysine (-CH2-CHO being converted to -CH(OH)-CHO) with a mass change of +16. The net change from Lys to hydroxyallysine thus is +15.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:00971
name: 2-Oxohistidine
def: "A protein modification that effectively converts an L-histidine residue to 2-oxohistidine." [PubMed:8405458, DeltaMass:38]
comment: From DeltaMass: Average Mass: 16 Average Mass Change:16 References:Lewisch, S. A. and Levine, R. L. (1995) Anal. Biochem. 231, 440-446. Determination of 2-oxo-histidine by amino acid analysis Notes:Rod LevineNIHBldg 3, Room 106 MSC 0320Bethesda, MD 20892-0320email: rlevine@nih.govvoice: 1 (301) 496-2310fax: 1 (301) 496-0599
xref: DiffAvg: "16"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 7 N 3 O 2"
xref: MassAvg: "153.14"
xref: MassMono: "153.053826"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:00677 ! hydroxylated residue

[Term]
id: MOD:00972
name: monobrominated L-phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to a monobrominated L-phenylalanine, such as L-2'-bromophenylalanine." [Unimod:340#F]
comment: From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa
synonym: "Br1Phe" EXACT PSI-MOD-label []
synonym: "bromination" RELATED Unimod-description []
synonym: "Bromo" RELATED PSI-MS-label []
xref: DiffAvg: "78.90"
xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0"
xref: DiffMono: "77.910512"
xref: Formula: "Br 1 C 9 H 8 N 1 O 1"
xref: MassAvg: "226.07"
xref: MassMono: "224.978926"
xref: Origin: "F"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:340"
is_a: MOD:02086 ! brominated phenylalanine
is_a: MOD:01912 ! monobrominated residue

[Term]
id: MOD:00973
name: Oxidation of proline (to glutamic acid)
def: "modification from DeltaMass" [DeltaMass:355]
comment: From DeltaMass: Average Mass: 32 Monoisotopic Mass Change:31.99 Average Mass Change:32 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Rod Levine (unpublished)
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:00974
name: (35)Cl labeled 3'-chlorotyrosine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 34
xref: DiffAvg: "33.96"
xref: DiffFormula: "(35)Cl 1 H -1"
xref: DiffMono: "33.961028"
xref: Formula: "C 9 (35)Cl 1 H 8 N 1 O 2"
xref: MassAvg: "197.02"
xref: MassMono: "197.024356"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:01046 ! 3'-chloro-L-tyrosine
is_a: MOD:00987 ! chlorinated tyrosine

[Term]
id: MOD:00975
name: (37)Cl labeled 3'-chlorotyrosine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 36
xref: DiffAvg: "35.96"
xref: DiffFormula: "(37)Cl 1 H -1"
xref: DiffMono: "35.958078"
xref: Formula: "C 9 (37)Cl 1 H 8 N 1 O 2"
xref: MassAvg: "199.02"
xref: MassMono: "199.021406"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:01046 ! 3'-chloro-L-tyrosine
is_a: MOD:00987 ! chlorinated tyrosine

[Term]
id: MOD:00976
name: potassium salt
def: "modification from DeltaMass - OBSOLETE because redundant and identical to MOD:01072. Remap to MOD:01072." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 38
xref: DiffAvg: "38.09"
xref: DiffFormula: "H -1 K 1"
xref: DiffMono: "37.955882"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:01072"
is_obsolete: true

[Term]
id: MOD:00977
name: disodium salt
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 44
subset: PSI-MOD-slim
xref: DiffAvg: "43.96"
xref: DiffFormula: "H -2 Na 2"
xref: DiffMono: "43.963888"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00747 ! sodium containing modified residue

[Term]
id: MOD:00978
name: piperidine adduct to C-terminal Cys
def: "modification from DeltaMass" [DeltaMass:345]
comment: From DeltaMass: Average Mass: 51 Average Mass Change: 51 References:Lukszo, Patterson, Albericio, and Kates, Letters in Peptide Science 3, 157-166(1996) Notes:The side reaction can be very significant, and the level to which it occurs depends on how the C-terminal Cys is anchored and what the side-chain protecting group is. The mechanism involves piperidine-mediated beta-elimination of sulfur (with the protecting group on), followed by addition of piperidine across the C-terminaldehydroalanine. Since this last-mentioned step creates a chiral center, a mixture of diastereomers is formed which in special cases can be separatedby HPLC. Another problem with C-terminal Cys is racemization; some references in the review article by Andreu, Albericio, Sole, Munson, Ferrer, and Barany in Pennington-Dunn Peptide Synthesis and Purification Protocols, vol 35, 1994, pp. 91-169.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:00979
name: t-butyl ester (OtBu) and t-butyl (tBu)
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 56
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:00980
name: Carboxamidomethyl (on Cysteine)
def: "modification from DeltaMass - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060." [DeltaMass:337]
comment: From DeltaMass: Average Mass: 57 Abbreviation:CamCys Formula:C2H3NO Monoisotopic Mass Change:57.021 Average Mass Change:57.051 Notes:Cysteine reacts with iodoacetamide to produce carboxamidomethyl cysteine. Alternative names are often used, such as amidocarboxymethylcysteine and carbamoylmethylcysteine
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:01060"
is_obsolete: true

[Term]
id: MOD:00981
name: sodium and potassium salt
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 60
subset: PSI-MOD-slim
xref: DiffAvg: "60.07"
xref: DiffFormula: "H -2 K 1 Na 1"
xref: DiffMono: "59.937826"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00747 ! sodium containing modified residue
is_a: MOD:00849 ! potassium containing modified residue

[Term]
id: MOD:00982
name: L-selenocysteine (Ser)
def: "A protein modification that effectively converts an L-serine residue to L-selenocysteine (not known as a natural post-translational modification process)." [DeltaMass:0]
comment: [From DeltaMass: Average Mass: 64.] Although selenocysteine-charged tRNA(Sec) is biosynthesized from serine-charged tRNA(Sec), in peptide work selenocysteine is usually considered as either a natural residue or as a modified cysteine residue. This entry is for the artifactual formation of L-selenocysteine from serine. For encoded L-selenocysteine, use MOD:00031 [JSG].
synonym: "Sec(Ser)" EXACT PSI-MOD-label []
synonym: "Selenocysteine (from Serine)" EXACT DeltaMass-label []
xref: DiffAvg: "62.97"
xref: DiffFormula: "C 0 H 0 N 0 O -1 Se 1"
xref: DiffMono: "63.921607"
xref: Formula: "C 3 H 5 N 1 O 1 Se 1"
xref: MassAvg: "150.05"
xref: MassMono: "150.953635"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:02088 ! natural, standard, encoded residue substitution

[Term]
id: MOD:00983
name: Asp transamidation with piperidine
def: "modification from DeltaMass" [DeltaMass:67]
comment: From DeltaMass: Average Mass: 67 Average Mass Change:67 References:http://www.abrf.org/archives/hmail/0008/0007.html Notes:1.) Get rid of the DBU. It can cause piperidine amides at Asp residues. The tbu ester side chain comes off during synthesis and the residue is trans-amidated with piperidine (+67Da by MS). If you haven't yet seen this, you will. Even "normal" 20% pip/DMF (NMP) will cause this, but less frequently. Literature exists for this; I don't remember the exact reference. David H. Singleton Scientist Pfizer Central Research PO Box 8118-101 Eastern Point Road Groton, CT 06340 (860)441-4404.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "D"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:00984
name: (35)Cl labeled 3',5'-dichlorotyrosine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 68
xref: DiffAvg: "67.92"
xref: DiffFormula: "(35)Cl 2 H -2"
xref: DiffMono: "67.922055"
xref: Formula: "C 9 (35)Cl 2 H 7 N 1 O 2"
xref: MassAvg: "230.99"
xref: MassMono: "230.985384"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:01045 ! 3',5'-dichloro-L-tyrosine
is_a: MOD:00987 ! chlorinated tyrosine

[Term]
id: MOD:00985
name: halogenated tyrosine
def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a halogen atom." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "HalTyr" EXACT PSI-MOD-label []
xref: Origin: "Y"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00694 ! halogen containing residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:00986
name: (35)Cl and (37)Cl labeled 3',5'-dichlorotyrosine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 70.
xref: DiffAvg: "69.92"
xref: DiffFormula: "(35)Cl 1 (37)Cl 1 H -2"
xref: DiffMono: "69.919105"
xref: Formula: "C 9 (35)Cl 1 (37)Cl 1 H 7 N 1 O 2"
xref: MassAvg: "232.98"
xref: MassMono: "232.982434"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:01045 ! 3',5'-dichloro-L-tyrosine
is_a: MOD:00987 ! chlorinated tyrosine

[Term]
id: MOD:00987
name: chlorinated tyrosine
def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a chlorine atom." [PubMed:18688235]
synonym: "ClTyr" EXACT PSI-MOD-label []
xref: Origin: "Y"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00753 ! chlorinated residue
is_a: MOD:00985 ! halogenated tyrosine

[Term]
id: MOD:00988
name: brominated tyrosine
def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a bromine atom." [PubMed:18688235]
synonym: "BrTyr" EXACT PSI-MOD-label []
xref: Origin: "Y"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00754 ! brominated residue
is_a: MOD:00985 ! halogenated tyrosine

[Term]
id: MOD:00989
name: acetamidomethyl (Acm)
def: "OBSOLETE because redundant, the difference component of MOD:01079. Remap to MOD:01079." [DeltaMass:0]
comment: From DeltaMass with no citation or formula.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:01079"
is_obsolete: true

[Term]
id: MOD:00990
name: (37)Cl labeled 3',5'-dichlorotyrosine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 72
xref: DiffAvg: "71.92"
xref: DiffFormula: "(37)Cl 2 H -2"
xref: DiffMono: "71.916155"
xref: Formula: "C 9 (37)Cl 2 H 7 N 1 O 2"
xref: MassAvg: "234.98"
xref: MassMono: "234.979484"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:01045 ! 3',5'-dichloro-L-tyrosine
is_a: MOD:00987 ! chlorinated tyrosine

[Term]
id: MOD:00991
name: S-(sn-1-glyceryl)-L-cysteine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 74 with no citation.
xref: DiffAvg: "74.08"
xref: DiffFormula: "C 3 H 6 O 2"
xref: DiffMono: "74.036779"
xref: Formula: "C 6 H 11 N 1 O 3 S 1"
xref: MassAvg: "177.22"
xref: MassMono: "177.045964"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:00992
name: glutamate 5-glycerol ester
def: "modification from DeltaMass" [DeltaMass:78, PubMed:18767873]
comment: From DeltaMass: Average Mass: 74 Average Mass Change: 74 References: Anal. Biochem. 1993 Vol 208 No. 2 382-386, PubMed:8452236. [DeltaMass] This article only suggests this as a possible modification and does no characterization. Isolation and stuctural evidence for artifactual modification are found in PubMed:18767873 [JSG].
xref: DiffAvg: "74.08"
xref: DiffFormula: "C 3 H 6 O 2"
xref: DiffMono: "74.036779"
xref: Formula: "C 8 H 13 N 1 O 5"
xref: MassAvg: "203.19"
xref: MassMono: "203.079373"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:00993
name: phenyl ester
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 76, on acidic amino acids
synonym: "OPh" EXACT DeltaMass-label []
xref: DiffAvg: "76.10"
xref: DiffFormula: "C 6 H 4"
xref: DiffMono: "76.031300"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00994
name: (79)Br labeled 3'-bromotyrosine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 78
xref: DiffAvg: "77.91"
xref: DiffFormula: "(79)Br 1 H -1"
xref: DiffMono: "77.910512"
xref: Formula: "(79)Br 1 C 9 H 8 N 1 O 2"
xref: MassAvg: "240.97"
xref: MassMono: "240.973841"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:01025 ! 3'-bromo-L-tyrosine
is_a: MOD:01000 ! monobrominated tyrosine

[Term]
id: MOD:00995
name: (81)Br labeled 2'-bromophenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to (81)Br-L-2'-bromophenylalanine." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 80
xref: DiffAvg: "79.91"
xref: DiffFormula: "(81)Br 1 H -1"
xref: DiffMono: "79.908466"
xref: Formula: "(81)Br 1 C 9 H 8 N 1 O 1"
xref: MassAvg: "226.98"
xref: MassMono: "226.976879"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:00183 ! L-2'-bromophenylalanine
is_a: MOD:02086 ! brominated phenylalanine

[Term]
id: MOD:00996
name: (81)Br labeled 3'-bromotyrosine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 80
xref: DiffAvg: "79.91"
xref: DiffFormula: "(81)Br 1 H -1"
xref: DiffMono: "79.908466"
xref: Formula: "(81)Br 1 C 9 H 8 N 1 O 2"
xref: MassAvg: "242.97"
xref: MassMono: "242.971794"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:01025 ! 3'-bromo-L-tyrosine
is_a: MOD:01000 ! monobrominated tyrosine

[Term]
id: MOD:00997
name: cyclohexyl ester
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 82
synonym: "OcHex" EXACT DeltaMass-label []
xref: DiffAvg: "82.15"
xref: DiffFormula: "C 6 H 10"
xref: DiffMono: "82.078250"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:00998
name: iodinated tyrosine
def: "A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with an iodine atom." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ITyr" EXACT PSI-MOD-label []
xref: Origin: "Y"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00755 ! iodinated residue
is_a: MOD:00985 ! halogenated tyrosine

[Term]
id: MOD:00999
name: homoseryl lactone
def: "OBSOLETE because redundant and identical to MOD:00404. Remap to MOD:00404." [DeltaMass:90]
comment: From DeltaMass: Average Mass: 83 Formula:C4H5O1N1 Monoisotopic Mass Change:83.037 Average Mass Change:83.09
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00404"
is_obsolete: true

[Term]
id: MOD:01000
name: monobrominated tyrosine
def: "A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one bromine atom." [PubMed:18688235]
synonym: "Br1Tyr" EXACT PSI-MOD-label []
xref: Origin: "Y"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00988 ! brominated tyrosine

[Term]
id: MOD:01001
name: 2-aminoisobutyric acid residue (Aib)
def: "A protein modification that inserts or replaces a residue with a 2-aminoisobutyric acid." [DeltaMass:0]
comment: Modification from DeltaMass: Average Mass: 85.
synonym: "2-amino-2-methylpropanoic acid" EXACT PSI-MOD-alternate []
synonym: "2-amino-2-methylpropionic acid" EXACT PSI-MOD-alternate []
synonym: "2-methylalanine" EXACT PSI-MOD-alternate []
synonym: "Aib" EXACT PSI-MOD-alternate []
synonym: "alpha,alpha-dimethylglycine" EXACT PSI-MOD-alternate []
synonym: "alpha-aminoisobutyric acid" EXACT PSI-MOD-alternate []
synonym: "alpha-methylalanine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 4 H 7 N 1 O 1"
xref: MassAvg: "85.11"
xref: MassMono: "85.052764"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00850 ! unnatural residue

[Term]
id: MOD:01002
name: gamma-aminobutyryl
def: "modification from DeltaMass" [DeltaMass:92]
comment: From DeltaMass: Average Mass: 85 Formula: C 4 H 7 O 1 N 1 Monoisotopic Mass Change: 85.053 Average Mass Change: 85.106
xref: DiffAvg: "85.11"
xref: DiffFormula: "C 4 H 7 N 1 O 1"
xref: DiffMono: "85.052764"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01003
name: t-butyloxymethyl (Bum)
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 86
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01004
name: diaminopropionyl
def: "modification from DeltaMass" [DeltaMass:95]
comment: From DeltaMass: Average Mass: 86 Formula: C 3 H 6 O 2 N 1 Monoisotopic Mass Change: 86.048 Average Mass Change: 86.094
xref: DiffAvg: "86.09"
xref: DiffFormula: "C 3 H 6 N 2 O 1"
xref: DiffMono: "86.048013"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01005
name: t-butylsulfenyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 88
synonym: "StBu" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01006
name: dibrominated tyrosine
def: "A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two bromine atoms." [Unimod:534]
synonym: "Br2Tyr" EXACT PSI-MOD-label []
synonym: "Dibromo" RELATED PSI-MS-label []
synonym: "Dibromo" RELATED Unimod-description []
xref: Origin: "Y"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:534"
is_a: MOD:00988 ! brominated tyrosine

[Term]
id: MOD:01007
name: anisyl modified residue
def: "A protein modification that effectively substitutes an anisyl (methoxyphenyl) group for a hydroxyl group, typically at the 4 or para position." [DeltaMass:0]
comment: From DeltaMass with no citation or formula: Average Mass: 90.
xref: DiffAvg: "90.13"
xref: DiffFormula: "C 7 H 6"
xref: DiffMono: "90.046950"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01008
name: benzyl (Bzl) and benzyl ester (OBzl) modified residue
def: "A protein modification that effectively substitutes a benzyl (phenylmethyl) group for a hydrogen atom." [DeltaMass:0]
comment: From DeltaMass with no citation or formula: Average Mass: 90
xref: DiffAvg: "90.13"
xref: DiffFormula: "C 7 H 6"
xref: DiffMono: "90.046950"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01009
name: dehydrogenated proline
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass with no citation.
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 5 H 5 N 1 O 1"
xref: MassAvg: "95.10"
xref: MassMono: "95.037114"
xref: Origin: "P"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00915 ! modified L-proline residue
is_a: MOD:01888 ! didehydrogenated residue

[Term]
id: MOD:01010
name: trifluoroacetylated residue
def: "A protein modification that effectively substitutes a trifluoroacetyl group for a hydrogen atom." [DeltaMass:0]
synonym: "TFA" EXACT DeltaMass-label []
xref: DiffAvg: "96.01"
xref: DiffFormula: "C 2 F 3 H -1 O 1"
xref: DiffMono: "95.982299"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00498 ! fluorinated residue
is_a: MOD:00649 ! acylated residue
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01011
name: N-hydroxysuccinimide (ONSu, OSu)
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 97
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01012
name: oxidation of disulfide crosslink in cystine to two cysteic acids
def: "A protein modification that effectively oxidizes the disulfide bond of a cystine crosslink to form two cysteic acid residues." [DeltaMass:335]
comment: Cross-link 2. This modification destroys a cross-link. From DeltaMass: Average Mass: 98 Abbreviation: Cya Average Mass Change: 98 Notes: Treatment of cystine by strongly oxidising reagents such as performic acid results in the breakage of the disulphide bond and complete oxidation of the sulphur atoms on each molecule. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure.
xref: DiffAvg: "98.01"
xref: DiffFormula: "C 0 H 2 N 0 O 6 S 0"
xref: DiffMono: "97.985138"
xref: Formula: "C 6 H 10 N 2 O 8 S 2"
xref: MassAvg: "302.27"
xref: MassMono: "301.987857"
xref: Origin: "MOD:00034"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:00034 ! L-cystine (cross-link)
is_a: MOD:00675 ! oxidized residue

[Term]
id: MOD:01013
name: tetramethylguanidinium termination by-product on amine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 98
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01014
name: phosphate/sulphate adduct of proteins
def: "modification from DeltaMass" [DeltaMass:358]
comment: From DeltaMass: Average Mass: 98 Formula:H3PO4 or H2SO4 Monoisotopic Mass Change:97.97 Average Mass Change:98 Notes:Proteins may pick up non-covalent salt adducts during purification. Phosphate and sulphate salts are commonly used and may be observed as +98 amu adducts (or multiples thereof) forming ion pairs with basic residues. Monoisotopic masses H2SO4 97.967, H3PO4 97.977
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01015
name: isovaline residue (Iva)
def: "A protein modification that inserts or replaces a residue with an isovaline." [DeltaMass:110]
synonym: "2-amino-2-methylbutanoic acid" EXACT PSI-MOD-alternate []
synonym: "Isovalyl (-I-,-Iva-)" EXACT DeltaMass-label []
synonym: "Iva" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 5 H 9 N 1 O 1"
xref: MassAvg: "99.13"
xref: MassMono: "99.068414"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00850 ! unnatural residue

[Term]
id: MOD:01016
name: t-butyloxycarbonyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 100
synonym: "tBoc" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01017
name: homoseryl (-Hse-)
def: "OBSOLETE because redundant and identical to MOD:00403. Remap to MOD:00403." [DeltaMass:113]
comment: From DeltaMass: Average Mass: 101 Abbreviation:-Hse- Formula:C4H7O2N Monoisotopic Mass Change:101.048 Average Mass Change:101.105
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00403"
is_obsolete: true

[Term]
id: MOD:01018
name: 4-methylbenzyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 104
synonym: "Meb" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01019
name: hydroxymethylphenyl linker
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 106
synonym: "HMP" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01020
name: thioanisyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 106
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01021
name: thiocresyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 106
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01022
name: 2-piperidinecarboxylic acid
def: "A protein modification that effectively converts an L-lysine residue to 2-piperidinecarboxylic acid." [DeltaMass:0]
synonym: "Pip" EXACT DeltaMass-label []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 6 H 9 N 1 O 1"
xref: MassAvg: "111.14"
xref: MassMono: "111.068414"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00601 ! cyclized residue
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01160 ! deaminated residue

[Term]
id: MOD:01023
name: 3',5'-dibromo-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to 3',5'-dibromo-L-tyrosine." [DeltaMass:156]
synonym: "3',5'-Br2Tyr" EXACT PSI-MOD-label []
xref: DiffAvg: "157.79"
xref: DiffFormula: "Br 2 C 0 H -2 N 0 O 0"
xref: DiffMono: "155.821024"
xref: Formula: "Br 2 C 9 H 7 N 1 O 2"
xref: MassAvg: "320.97"
xref: MassMono: "318.884353"
xref: Origin: "Y"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:01006 ! dibrominated tyrosine

[Term]
id: MOD:01024
name: monohydroxylated proline
def: "A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline." [DeltaMass:0, OMSSA:62, Unimod:35#P]
comment: From DeltaMass: Average Mass: 131. This is the mass of the free amino acid [JSG].
subset: PSI-MOD-slim
synonym: "Hy1Pro" EXACT PSI-MOD-label []
synonym: "hydroxylationp" EXACT OMSSA-label []
synonym: "Hydroxyproline" EXACT DeltaMass-label []
synonym: "Hyp" EXACT DeltaMass-label []
synonym: "Oxidation" RELATED PSI-MS-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 7 N 1 O 2"
xref: MassAvg: "113.12"
xref: MassMono: "113.047678"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:35"
xref: uniprot.ptm:PTM-0149
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:00594 ! residues isobaric at 113.047678 Da
is_a: MOD:00678 ! hydroxylated proline

[Term]
id: MOD:01025
name: 3'-bromo-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to 3'-bromo-L-tyrosine." [PubMed:18688235]
synonym: "3'-BrTyr" EXACT PSI-MOD-label []
xref: DiffAvg: "78.90"
xref: DiffFormula: "Br 1 H -1"
xref: DiffMono: "77.910512"
xref: Formula: "Br 1 C 9 H 8 N 1 O 2"
xref: MassAvg: "242.07"
xref: MassMono: "240.973841"
xref: Origin: "Y"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:01000 ! monobrominated tyrosine

[Term]
id: MOD:01026
name: norleucine residue (Nle)
def: "A protein modification that inserts or replaces a residue with a norleucine." [DeltaMass:126]
synonym: "Nle" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 6 H 11 N 1 O 1"
xref: MassAvg: "113.16"
xref: MassMono: "113.084064"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00850 ! unnatural residue
is_a: MOD:00306 ! residues isobaric at 113.084064 Da

[Term]
id: MOD:01027
name: t-amyloxycarbonyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 114
synonym: "Aoc" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01028
name: monochlorinated L-tyrosine
def: "A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one chlorine atom." [PubMed:18688235]
synonym: "Cl1Tyr" EXACT PSI-MOD-label []
xref: DiffAvg: "34.44"
xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0"
xref: DiffMono: "33.961028"
xref: Formula: "C 9 Cl 1 H 8 N 1 O 2"
xref: MassAvg: "197.62"
xref: MassMono: "197.024356"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00987 ! chlorinated tyrosine
is_a: MOD:01911 ! monochlorinated residue

[Term]
id: MOD:01029
name: succinylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a succinyl group linked through a carbonyl carbon." [DeltaMass:0, Unimod:64]
comment: From DeltaMass with no citation or formula, Average Mass: 117 [JSG].
subset: PSI-MOD-slim
synonym: "Succinic anhydride labeling reagent light form (N-term & K)" RELATED Unimod-description []
xref: DiffAvg: "100.07"
xref: DiffFormula: "C 4 H 4 O 3"
xref: DiffMono: "100.016044"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:64"
is_a: MOD:00649 ! acylated residue

[Term]
id: MOD:01030
name: hydroxybenzotriazole ester
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 117
synonym: "HOBt" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01031
name: dimethylbenzyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 118
synonym: "diMeBzl" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01032
name: benzyloxymethyl modified residue
def: "A protein modification that effectively substitutes a benzyloxymethyl group for a hydrogen atom." [DeltaMass:0]
synonym: "Bom" EXACT DeltaMass-label []
xref: DiffAvg: "120.15"
xref: DiffFormula: "C 8 H 8 O 1"
xref: DiffMono: "120.057515"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01033
name: p-methoxybenzyl modified residue
def: "A protein modification that effectively substitutes a p-methoxybenzyl group for a hydrogen atom." [DeltaMass:0]
synonym: "Mbzl" EXACT DeltaMass-label []
synonym: "Mob" EXACT DeltaMass-label []
xref: DiffAvg: "120.15"
xref: DiffFormula: "C 8 H 8 O 1"
xref: DiffMono: "120.057515"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01034
name: 4-nitrophenyl modified residue
def: "A protein modification that effectively substitutes a 4-nitrophenyl group for a hydrogen atom." [DeltaMass:0]
synonym: "ONp" EXACT DeltaMass-label []
synonym: "p-nitrophenyl" EXACT DeltaMass-label []
xref: DiffAvg: "121.10"
xref: DiffFormula: "C 6 H 3 N 1 O 2"
xref: DiffMono: "121.016378"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01035
name: chlorobenzyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 125
synonym: "ClBzl" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01036
name: O-methyl aspartyl
def: "OBSOLETE because redundant and identical to MOD:01181. Remap to MOD:01181." [PubMed:18688235]
comment: From DeltaMass:148 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 129 Formula: C5H7O1N3 Monoisotopic Mass Change: 129.042 Average Mass Change: 129.116
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "D"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:01181"
is_obsolete: true

[Term]
id: MOD:01037
name: dichlorinated tyrosine
def: "A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two chlorine atoms." [PubMed:18688235]
synonym: "Cl2Tyr" EXACT PSI-MOD-label []
xref: DiffAvg: "68.88"
xref: DiffFormula: "C 0 Cl 2 H -2 N 0 O 0"
xref: DiffMono: "67.922055"
xref: Formula: "C 9 Cl 2 H 7 N 1 O 2"
xref: MassAvg: "232.06"
xref: MassMono: "230.985384"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00987 ! chlorinated tyrosine

[Term]
id: MOD:01038
name: norleucine (Nle)
def: "OBSOLETE because this represents a free amino acid and the corresponding residue is MOD:01026." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 131.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:01039
name: hydroxy aspartyl
def: "OBSOLETE because redundant and identical to MOD:00036. Remap to MOD:00036." [PubMed:18688235]
comment: From DeltaMass:152 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 131 Formula:C4H5O1N4 Monoisotopic Mass Change:131.022 Average Mass Change:131.088
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 4 H 5 N 1 O 4"
xref: MassAvg: "131.09"
xref: MassMono: "131.021858"
xref: Origin: "D"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:00036"
is_obsolete: true

[Term]
id: MOD:01040
name: penicillamine residue
def: "A protein modification that inserts or replaces a residue with a penicillamine." [DeltaMass:154]
comment: From DeltaMass: Name misspelled 'bb-dimethyl cystenyl'. No citation provided.
synonym: "2-amino-3-mercapto-3-methylbutanoic acid" EXACT PSI-MOD-alternate []
synonym: "2-amino-3-methyl-3-sulfanylbutanoic acid" EXACT PSI-MOD-alternate []
synonym: "3,3-dimethylcysteine" EXACT PSI-MOD-alternate []
synonym: "3-mercapto-L-valine" EXACT PSI-MOD-alternate []
synonym: "beta,beta-dimethylcysteine" EXACT DeltaMass-label []
synonym: "Pen" EXACT DeltaMass-label []
synonym: "Pen" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 5 H 9 N 1 O 1 S 1"
xref: MassAvg: "131.19"
xref: MassMono: "131.040485"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00850 ! unnatural residue

[Term]
id: MOD:01041
name: benzyloxycarbonyl modified residue
def: "A protein modification that effectively substitutes a benzyloxycarbonyl group for a hydrogen atom." [DeltaMass:0]
synonym: "Z" EXACT DeltaMass-label []
xref: DiffAvg: "134.13"
xref: DiffFormula: "C 8 H 6 O 2"
xref: DiffMono: "134.036779"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01042
name: adamantyl modified residue
def: "A protein modification that effectively substitutes a adamantyl group for a hydrogen atom." [DeltaMass:0]
synonym: "Ada" EXACT DeltaMass-label []
xref: DiffAvg: "134.22"
xref: DiffFormula: "C 10 H 14"
xref: DiffMono: "134.109550"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01043
name: p-nitrobenzyl ester modified residue
def: "A protein modification that effectively substitutes a p-nitrobenzyl group for the hydrogen atom of a carboxyl group." [DeltaMass:0]
synonym: "ONb" EXACT DeltaMass-label []
xref: DiffAvg: "135.12"
xref: DiffFormula: "C 7 H 5 N 1 O 2"
xref: DiffMono: "135.032028"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01044
name: N-methyl glutamyl
def: "OBSOLETE because redundant and identical to MOD:00080. Remap to MOD:00080." [DeltaMass:166]
comment: From DeltaMass with no citation. Formula:C6H10O2N2 (name misspelled, formula for N5-methylglutaminyl, rather than N2-methylglutamyl)
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "Q"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:00080"
is_obsolete: true

[Term]
id: MOD:01045
name: 3',5'-dichloro-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to 3',5'-dichloro-L-tyrosine." [PubMed:18688235]
synonym: "3',5'-Cl2Tyr" EXACT PSI-MOD-label []
xref: DiffAvg: "68.88"
xref: DiffFormula: "C 0 Cl 2 H -2 N 0 O 0"
xref: DiffMono: "67.922055"
xref: Formula: "C 9 Cl 2 H 7 N 1 O 2"
xref: MassAvg: "232.06"
xref: MassMono: "230.985384"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01037 ! dichlorinated tyrosine

[Term]
id: MOD:01046
name: 3'-chloro-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to 3'-chloro-L-tyrosine." [PubMed:18688235]
synonym: "3'-ClTyr" EXACT PSI-MOD-label []
xref: DiffAvg: "34.44"
xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0"
xref: DiffMono: "33.961028"
xref: Formula: "C 9 Cl 1 H 8 N 1 O 2"
xref: MassAvg: "197.62"
xref: MassMono: "197.024356"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01028 ! monochlorinated L-tyrosine

[Term]
id: MOD:01047
name: monohydroxylated lysine
def: "A protein modification that effectively converts an L-lysine residue to a monohydroxylated lysine." [DeltaMass:168, OMSSA:60, Unimod:35#K]
comment: From DeltaMass: Average Mass: 144 Abbreviation:-Hyl- Formula:C6H12N2O2 Monoisotopic Mass Change:144.09 Average Mass Change:144.174.
subset: PSI-MOD-slim
synonym: "Hy1Lys" EXACT PSI-MOD-label []
synonym: "Hydroxy Lysyl (-Hyl-)" EXACT DeltaMass-label []
synonym: "hydroxylationk" EXACT OMSSA-label []
synonym: "Oxidation" RELATED PSI-MS-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 12 N 2 O 2"
xref: MassAvg: "144.17"
xref: MassMono: "144.089878"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:35"
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:00681 ! hydroxylated lysine

[Term]
id: MOD:01048
name: 2-pyrrolidone-5-carboxylic acid
def: "A protein modification that effectively converts a source amino acid residue to 2-pyrrolidone-5-carboxylic acid." [PubMed:18688235]
comment: From DeltaMass: Average Mass: -18 Average Mass Change: -18.01 References:The conversion of glutamic acid to pyroglutamic was reported for the beta-amiloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52.
subset: PSI-MOD-slim
synonym: "PyrGlu" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 5 H 6 N 1 O 2"
xref: MassAvg: "112.11"
xref: MassMono: "112.039853"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "N-term"
is_a: MOD:00601 ! cyclized residue
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:01049
name: halogenated histidine
def: "A protein modification that effectively substitutes a hydrogen atom of an L-histidine residue with a halogen atom." [PubMed:18688235]
synonym: "HalHis" EXACT PSI-MOD-label []
xref: Origin: "H"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00694 ! halogen containing residue
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:01050
name: pyridyl alanyl
def: "modification from DeltaMass" [DeltaMass:180]
comment: From DeltaMass: Average Mass: 148 Formula:C8H8O2N1 Monoisotopic Mass Change:148.064 Average Mass Change:148.165
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "A"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01051
name: 2-nitrobenzoyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 149
synonym: "NBz" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01052
name: dimethoxybenzyl Trp
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 150
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01053
name: 2-nitrophenylsulphenyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 153
synonym: "Nps" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01054
name: 4-toluenesulfonyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 154
synonym: "4-toluenesulphonyl" EXACT DeltaMass-label []
synonym: "Tos" EXACT DeltaMass-label []
synonym: "Tosyl" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01055
name: 3-nitro-2-pyridinesulfenyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 154
synonym: "Npys" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01056
name: (79)Br labeled 3',5'-dibromotyrosine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 156
xref: DiffAvg: "155.82"
xref: DiffFormula: "(79)Br 2 C 0 H -2 N 0 O 0"
xref: DiffMono: "155.821024"
xref: Formula: "(79)Br 2 C 9 H 7 N 1 O 2"
xref: MassAvg: "318.88"
xref: MassMono: "318.884353"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:01023 ! 3',5'-dibromo-L-tyrosine
is_a: MOD:01006 ! dibrominated tyrosine

[Term]
id: MOD:01057
name: (79)Br and (81)Br labeled 3',5'-dibromotyrosine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 158
xref: DiffAvg: "157.82"
xref: DiffFormula: "(79)Br 1 (81)Br 1 C 0 H -2 N 0 O 0"
xref: DiffMono: "157.818978"
xref: Formula: "(79)Br 1 (81)Br 1 C 9 H 7 N 1 O 2"
xref: MassAvg: "320.88"
xref: MassMono: "320.882306"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:01023 ! 3',5'-dibromo-L-tyrosine
is_a: MOD:01006 ! dibrominated tyrosine

[Term]
id: MOD:01058
name: dichlorobenzyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 159
synonym: "Dcb" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01059
name: (81)Br labeled 3',5'-dibromotyrosine
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 160
xref: DiffAvg: "159.82"
xref: DiffFormula: "(81)Br 2 C 0 H -2 N 0 O 0"
xref: DiffMono: "159.816931"
xref: Formula: "(81)Br 2 C 9 H 7 N 1 O 2"
xref: MassAvg: "322.88"
xref: MassMono: "322.880260"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:01023 ! 3',5'-dibromo-L-tyrosine
is_a: MOD:01006 ! dibrominated tyrosine

[Term]
id: MOD:01060
name: S-carboxamidomethyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine." [DeltaMass:196, DeltaMass:337, OMSSA:3, PubMed:10504701, PubMed:11510821, PubMed:12422359, PubMed:18306178, Unimod:4#C]
comment: From DeltaMass: (name misspelled "Carboxyamidomethyl Cystenyl") [JSG].
subset: PSI-MOD-slim
synonym: "amidocarboxymethylcysteine" EXACT DeltaMass-label []
synonym: "CamC" EXACT PSI-MOD-alternate []
synonym: "CamCys" EXACT DeltaMass-label []
synonym: "Carbamidomethyl" RELATED PSI-MS-label []
synonym: "carbamidomethylc" EXACT OMSSA-label []
synonym: "carbamoylmethylcysteine" EXACT DeltaMass-label []
synonym: "Carboxamidomethyl (on Cysteine)" EXACT DeltaMass-label []
synonym: "Carboxyamidomethyl Cystenyl" EXACT DeltaMass-label []
synonym: "Iodoacetamide derivative" RELATED Unimod-description []
synonym: "S-carbamoylmethyl-L-cysteine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "57.05"
xref: DiffFormula: "C 2 H 3 N 1 O 1 S 0"
xref: DiffMono: "57.021464"
xref: Formula: "C 5 H 8 N 2 O 2 S 1"
xref: MassAvg: "160.19"
xref: MassMono: "160.030649"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:4"
is_a: MOD:00397 ! iodoacetamide derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01061
name: S-carboxymethyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine." [DeltaMass:0, DeltaMass:197, OMSSA:2, Unimod:6#C]
comment: From DeltaMass with no citation, name misspelled "Carboxymethyl Cystenyl", and formula incorrect, N and O reversed: Average Mass: 161 Abbreviation: -Cmc- Formula: C5H7O1N3S1 Monoisotopic Mass Change: 161.015 Average Mass Change: 161.179 [JSG].
subset: PSI-MOD-slim
synonym: "Carboxymethyl" RELATED PSI-MS-label []
synonym: "Carboxymethyl cysteine" EXACT DeltaMass-label []
synonym: "Carboxymethyl Cystenyl" EXACT DeltaMass-label []
synonym: "carboxymethylc" EXACT OMSSA-label []
synonym: "CmC" EXACT PSI-MOD-alternate []
synonym: "Iodoacetic acid derivative" RELATED Unimod-description []
xref: DiffAvg: "58.04"
xref: DiffFormula: "C 2 H 2 N 0 O 2 S 0"
xref: DiffMono: "58.005479"
xref: Formula: "C 5 H 7 N 1 O 3 S 1"
xref: MassAvg: "161.18"
xref: MassMono: "161.014664"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:6"
is_a: MOD:00399 ! iodoacetic acid derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01062
name: carboxymethyl cysteinyl
def: "OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061" [DeltaMass:197]
comment: From DeltaMass:197 (Name misspelled "cystenyl", and formula incorrect, N and O reversed) Abbreviation:-Cmc- Formula:C5H7O1N3S1 Monoisotopic Mass Change:161.015 Average Mass Change:161.179
synonym: "Carboxymethyl Cystenyl" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 5 H 7 N 3 O 1 S 1"
xref: MassAvg: "157.19"
xref: MassMono: "157.030983"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:01061"
is_obsolete: true

[Term]
id: MOD:01063
name: monomethylated phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to a monomethylated phenylalanine." [DeltaMass:198]
comment: From DeltaMass: Average Mass: 161 Formula: C10H11O1N1 Monoisotopic Mass Change: 161.084 Average Mass Change: 161.205. No citation provided. It is not obvious whether the DeltaMass entry is supposed to represent N-methylphenylalanine, alpha-methylphenylalanine, 2'-, 3'-, or 4'-methylphenylalanine [JSG].
subset: PSI-MOD-slim
synonym: "NMePhe" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 10 H 11 N 1 O 1"
xref: MassAvg: "161.20"
xref: MassMono: "161.084064"
xref: Origin: "F"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00717 ! methylated phenylalanine

[Term]
id: MOD:01064
name: inositol
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 162
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01065
name: hexose glycated N-terminal
def: "A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein N-terminal amino group to form a Schiff-base or an Amadori ketosamine  (or aminoketose) residue adduct." [DeltaMass:0, Unimod:41#N-term]
comment: From DeltaMass: Average Mass: 162
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:41"
is_a: MOD:00767 ! glycated residue

[Term]
id: MOD:01066
name: halogenated phenylalanine
def: "A protein modification that effectively substitutes a hydrogen atom of an L-phenylalanine residue with a halogen atom." [PubMed:18688235]
synonym: "HalPhe" EXACT PSI-MOD-label []
xref: Origin: "F"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00694 ! halogen containing residue
is_a: MOD:00914 ! modified L-phenylalanine residue

[Term]
id: MOD:01067
name: linker attached to peptide in Fmoc peptide synthesis
def: "modification from DeltaMass" [DeltaMass:341]
comment: From DeltaMass: Average Mass: 162 Average Mass Change:162 Notes: (from the ABRF discussion list archive) There may be ... things in the reagent K that would allow cleavage of the peptide to occur at the wrong place...in this case it removes the dimethoxybenzyl group first inactivating that site for cleavage, and it goes after tne next amide bond closer to the resin. Try the TFA/TIS/water/EDT cocktail...TFA = 92%, TIS =3%, and water is at 5%. .. had this issue on longer peptides.. and by increasing the amount of water a little bit... able to elminate this problem.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01068
name: halogenated tryptophan
def: "A protein modification that effectively substitutes a hydrogen atom of an L-tryptophan residue with a halogen atom." [PubMed:18688235]
synonym: "HalTrp" EXACT PSI-MOD-label []
xref: Origin: "W"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00694 ! halogen containing residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:01069
name: 2,4-dinitrophenyl modified residue
def: "A protein modification that effectively substitutes a 2,4-dinitrophenyl group for a hydrogen atom." [DeltaMass:0]
synonym: "Dnp" EXACT DeltaMass-label []
xref: DiffAvg: "166.09"
xref: DiffFormula: "C 6 H 2 N 2 O 4"
xref: DiffMono: "166.001457"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01070
name: pentafluorophenyl modified residue
def: "A protein modification that effectively substitutes a pentafluorophenyl group for a hydrogen atom." [DeltaMass:0]
comment: From DeltaMass: name mispelled "pentaflourophenyl"
synonym: "Pfp" EXACT DeltaMass-label []
xref: DiffAvg: "166.05"
xref: DiffFormula: "C 6 F 5 H -1"
xref: DiffMono: "165.984191"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01071
name: diphenylmethyl modified residue
def: "A protein modification that effectively substitutes a diphenylmethyl group for a hydrogen atom." [DeltaMass:0]
synonym: "Dpm" EXACT DeltaMass-label []
xref: DiffAvg: "166.22"
xref: DiffFormula: "C 13 H 10"
xref: DiffMono: "166.078250"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01072
name: monopotassium salt
def: "A protein modification that effectively substitutes one potassium atom for one hydrogen atom." [DeltaMass:0]
subset: PSI-MOD-slim
synonym: "K1Res" EXACT PSI-MOD-label []
xref: DiffAvg: "38.09"
xref: DiffFormula: "H -1 K 1"
xref: DiffMono: "37.955882"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00849 ! potassium containing modified residue

[Term]
id: MOD:01073
name: 2-chlorobenzyloxycarbonyl modified residue
def: "A protein modification that effectively substitutes a 2-chlorobenzyloxycarbonyl group for a hydrogen atom." [DeltaMass:0]
synonym: "Clz" EXACT DeltaMass-label []
xref: DiffAvg: "169.58"
xref: DiffFormula: "C 8 Cl 1 H 6 O 2"
xref: DiffMono: "169.005632"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01074
name: napthylacetyl modified residue
def: "A protein modification that effectively substitutes a napthylacetyl group for a hydrogen atom." [DeltaMass:0]
xref: DiffAvg: "169.20"
xref: DiffFormula: "C 12 H 9 O 1"
xref: DiffMono: "169.065340"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01075
name: mercury containing modified residue
def: "A protein modification that effectively substitutes a mercury atom or a cluster containing mercury for hydrogen atoms, or that coordinates a mercury ion." [PubMed:18688235]
synonym: "HgRes" EXACT PSI-MOD-label []
is_a: MOD:00698 ! metal or metal cluster containing modified residue

[Term]
id: MOD:01076
name: N-methyl arginyl
def: "modification from DeltaMass - OBSOLETE because redundant and identical to MOD:00414. Remap to MOD:00414." [DeltaMass:215]
comment: From DeltaMass: Average Mass: 170 Formula:C7H14O4N1 Monoisotopic Mass Change:170.117 Average Mass Change:170.215
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 7 H 14 N 4 O 1"
xref: MassAvg: "170.22"
xref: MassMono: "170.116761"
xref: Origin: "R"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:00414"
is_obsolete: true

[Term]
id: MOD:01077
name: ethanedithiol/TFA cyclic adduct
def: "modification from DeltaMass" [DeltaMass:216]
comment: From DeltaMass: Average Mass: 172 Average Mass Change:172 References:[1]. Sieber,P.(1987) Modification of tryptophan residues during acidolysis of4-methoxy-2,3,6-trimethylbenzenesulfonyl groups. Effects of scavengers. Tetrahedron Lett., 28(15),1637-1640. Notes: TFA-cyclic dithioketal by-product is formed when Trp-containing peptide is subjected to prolonged TFA/EDT treatment [1]. See structure at http://www.abrf.org/images/misc/dmass172.gif. Additional discussion of this adduct, and how to avoid it, can befound in Methods in Enzymology 289, 67 (1997)
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01078
name: S-(2-aminoethyl)-3-methylcysteine (Thr)
def: "A protein modification that effectively converts an L-threonine residue to S-(2-aminoethyl)-3-methylcysteine." [PubMed:12923550, Unimod:472#T]
comment: From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex.
synonym: "2-amino-3-(2-aminoethyl)sulfanyl-3-methylbutanoic acid" EXACT PSI-MOD-alternate []
synonym: "AEC-MAEC" RELATED Unimod-interim []
synonym: "beta-methylaminoethylcysteine" RELATED Unimod-description []
synonym: "S-aminoethyl-3-methylcysteine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "59.13"
xref: DiffFormula: "C 2 H 5 N 1 O -1 S 1"
xref: DiffMono: "59.019356"
xref: Formula: "C 6 H 12 N 2 O 1 S 1"
xref: MassAvg: "160.24"
xref: MassMono: "160.067034"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:472"
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01079
name: S-(acetylamino)methyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-[(acetylamino)methyl]-L-cysteine." [DeltaMass:218, PubMed:8572278]
comment: From DeltaMass: (name misspelled "Acetamidomethyl Cystenyl") Average Mass: 174 Formula: C 6 H 10 O 2 N 2 S 1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221. [These are aggregate masses, not delta masses.] See Organic Syntheses, Coll. Vol. 6, p.5 (1988); Vol. 59, p.190 (1979); http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv6p0005 [JSG].
synonym: "Acetamidomethyl Cystenyl" EXACT DeltaMass-label []
synonym: "Acm-Cys" EXACT PSI-MOD-alternate []
synonym: "N-(hydroxymethyl)acetamide derivatized L-cysteine" EXACT PSI-MOD-alternate []
synonym: "S-(acetamido)methyl-L-cysteine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "71.08"
xref: DiffFormula: "C 3 H 5 N 1 O 1 S 0"
xref: DiffMono: "71.037114"
xref: Formula: "C 6 H 10 N 2 O 2 S 1"
xref: MassAvg: "174.22"
xref: MassMono: "174.046299"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01080
name: acrylamidyl cysteinyl
def: "OBSOLETE because this is identical to MOD:00417.  modification from DeltaMass" [DeltaMass:219]
comment: From DeltaMass: (name misspelled "Acrylamidyl Cystenyl") Average Mass: 174 Formula: C6H10O2N2S1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221
synonym: "Acrylamidyl Cystenyl" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 6 H 10 N 2 O 2 S 1"
xref: MassAvg: "174.22"
xref: MassMono: "174.046299"
xref: Origin: "C"
xref: Source: "artifact"
xref: Remap: "MOD:00417"
is_obsolete: true

[Term]
id: MOD:01081
name: delta-glycosyloxy- (of lysine) or beta-glycosyloxy- (of phenylalanine or tyrosine)
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 177. CAUTION - mass does not match formula.
xref: DiffAvg: "178.14"
xref: DiffFormula: "C 6 H 10 O 6"
xref: DiffMono: "178.047738"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01082
name: 4-glycosyloxy- (hexosyl, C6) (of proline)
def: "OBSOLETE because redundant with MOD:00757, remap. modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 177. Caution: Formula does not match mass. The natural glycosylating sugar of hydroxyproline is galactose.
xref: DiffAvg: "178.14"
xref: DiffFormula: "C 6 H 10 O 6"
xref: DiffMono: "178.047738"
xref: Formula: "C 11 H 17 N 1 O 6"
xref: MassAvg: "259.26"
xref: MassMono: "259.105587"
xref: Origin: "P"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:00757"
is_obsolete: true

[Term]
id: MOD:01083
name: O-benzyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-benzyl-L-serine." [DeltaMass:0]
xref: DiffAvg: "90.13"
xref: DiffFormula: "C 7 H 6"
xref: DiffMono: "90.046950"
xref: Formula: "C 10 H 11 N 1 O 2"
xref: MassAvg: "177.20"
xref: MassMono: "177.078979"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue

[Term]
id: MOD:01084
name: iodoacetic acid derivatized amino-terminal residue
def: "A protein modification that by reaction of iodoacetic acid effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxymethyl group." [Unimod:6#N-term]
subset: PSI-MOD-slim
synonym: "Carboxymethyl" RELATED PSI-MS-label []
synonym: "Carboxymethyl (on Cysteine)" EXACT DeltaMass-label []
synonym: "Iodoacetic acid derivative" RELATED Unimod-description []
xref: DiffAvg: "58.04"
xref: DiffFormula: "C 2 H 2 O 2"
xref: DiffMono: "58.005479"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:6"
is_a: MOD:00399 ! iodoacetic acid derivatized residue

[Term]
id: MOD:01085
name: alpha-N-gluconoylated L-histidine
def: "A protein modification that effectively replaces the N-terminal hydrogen atom of a N-terminal histidine residue with a gluconoyl group linked through a glycosidic bond. modification from DeltaMass" [PubMed:9918669, DeltaMass:226]
comment: Occurs on His-tagged proteins expresssed in E. coli. From DeltaMass: Average Mass: 178 Formula: C6H10O6 Monoisotopic Mass Change: 178.05 Average Mass Change: 178.14 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. Mass listed here is 179 because it's N-terminal.
xref: DiffAvg: "179.15"
xref: DiffFormula: "C 6 H 11 O 6"
xref: DiffMono: "179.055563"
xref: Formula: "C 12 H 18 N 3 O 7"
xref: MassAvg: "316.29"
xref: MassMono: "316.114475"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:00006 ! N-glycosylated residue

[Term]
id: MOD:01086
name: p-nitrobenzyloxycarbonyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 179
synonym: "4Nz" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01087
name: 2,4,5-trichlorophenyl modified residue
def: "A protein modification that effectively substitutes a 2,4,5-trichlorophenyl group for a hydrogen atom." [DeltaMass:0]
xref: DiffAvg: "179.42"
xref: DiffFormula: "C 6 Cl 3 H 1"
xref: DiffMono: "177.914383"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01088
name: 2,4,6-trimethyloxybenzyl modified residue
def: "A protein modification that effectively substitutes a 2,4,6-trimethyloxybenzyl group for a hydrogen atom." [DeltaMass:0]
synonym: "Tmob" EXACT DeltaMass-label []
xref: DiffAvg: "180.20"
xref: DiffFormula: "C 10 H 12 O 3"
xref: DiffMono: "180.078644"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01089
name: xanthyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 180
synonym: "Xan" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01090
name: iodoacetamide derivatized amino-terminal residue
def: "A protein modification that by reaction of iodoacetamide effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxamidomethyl group." [PubMed:11327326, PubMed:11510821, PubMed:12422359, Unimod:4#N-term]
subset: PSI-MOD-slim
synonym: "(carbamoylmethyl)amino" EXACT PSI-MOD-alternate []
synonym: "Carbamidomethyl" RELATED PSI-MS-label []
synonym: "Iodoacetamide derivative" RELATED Unimod-description []
xref: DiffAvg: "57.05"
xref: DiffFormula: "C 2 H 3 N 1 O 1"
xref: DiffMono: "57.021464"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:4"
is_a: MOD:00397 ! iodoacetamide derivatized residue

[Term]
id: MOD:01091
name: monochlorinated L-phenylalanine
def: "A protein modification that effectively substitutes one hydrogen atom of an L-phenylalanine residue with one chlorine atom." [DeltaMass:233]
comment: From DeltaMass: Average Mass: 182 Formula:C9H8O1N1Cl1 Monoisotopic Mass Change:181.029 Average Mass Change:181.623
synonym: "Cl1Phe" EXACT PSI-MOD-label []
xref: DiffAvg: "34.44"
xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0"
xref: DiffMono: "33.961028"
xref: Formula: "C 9 Cl 1 H 8 N 1 O 1"
xref: MassAvg: "181.62"
xref: MassMono: "181.029442"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01066 ! halogenated phenylalanine
is_a: MOD:01911 ! monochlorinated residue

[Term]
id: MOD:01092
name: mesitylene-2-sulfonyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 182
synonym: "Mts" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01093
name: isopropyl lysyl
def: "modification from DeltaMass" [DeltaMass:236]
comment: From DeltaMass: Average Mass: 184 Formula: C9H16O2N2 Monoisotopic Mass Change: 184.12 Average Mass Change: 184.24 with no citation.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 9 H 16 N 2 O 2"
xref: MassAvg: "184.24"
xref: MassMono: "184.121178"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01094
name: N6-carboxymethyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-carboxymethyl-L-lysine." [DeltaMass:237, Unimod:6#K]
comment: From DeltaMass:237 (with no citation, formula incorrect, N and O reversed) Average Mass: 186 Formula: C8H14O2N3 Monoisotopic Mass Change: 186.1 Average Mass Change: 186.211 [JSG].
subset: PSI-MOD-slim
synonym: "Carboxymethyl" RELATED PSI-MS-label []
synonym: "Carboxymethyl Lysyl" EXACT DeltaMass-label []
synonym: "Iodoacetic acid derivative" RELATED Unimod-description []
xref: DiffAvg: "58.04"
xref: DiffFormula: "C 2 H 2 O 2"
xref: DiffMono: "58.005479"
xref: Formula: "C 8 H 14 N 2 O 3"
xref: MassAvg: "186.21"
xref: MassMono: "186.100442"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:6"
is_a: MOD:00399 ! iodoacetic acid derivatized residue

[Term]
id: MOD:01095
name: Matrix alpha cyano MH+
def: "Modification from DeltaMass. OBSOLETE because not an amino acid modification." [DeltaMass:240]
comment: From DeltaMass with no citation, formula incorrect, N and O reversed: Formula: C10H8O1N3 Monoisotopic Mass Change: 190.05 Average Mass Change: 190.18.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 10 H 8 N 1 O 3"
xref: MassAvg: "190.18"
xref: MassMono: "190.050418"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:01096
name: O-benzyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-benzyl-L-threonine." [DeltaMass:0]
xref: DiffAvg: "90.13"
xref: DiffFormula: "C 7 H 6"
xref: DiffMono: "90.046950"
xref: Formula: "C 11 H 13 N 1 O 2"
xref: MassAvg: "191.23"
xref: MassMono: "191.094629"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue

[Term]
id: MOD:01097
name: S-benzyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-benzyl-L-cysteine." [DeltaMass:242]
comment: From DeltaMass: misspelled "Benzyl Cystenyl".
xref: DiffAvg: "90.13"
xref: DiffFormula: "C 7 H 6"
xref: DiffMono: "90.046950"
xref: Formula: "C 10 H 11 N 1 O 1 S 1"
xref: MassAvg: "193.26"
xref: MassMono: "193.056135"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue

[Term]
id: MOD:01098
name: naphthylalanine residue
def: "A protein modification that inserts or replaces a residue with a naphthylalanine." [DeltaMass:243]
comment: From DeltaMass: Average Mass: 197 Formula: C13H11O1N1 Monoisotopic Mass Change: 197.084 Average Mass Change: 197.238. No citation provided. It is not obvious which isomer of naphthylalanine this DeltaMass entry is supposed to represent [JSG].
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 13 H 11 N 1 O 1"
xref: MassAvg: "197.24"
xref: MassMono: "197.084064"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00850 ! unnatural residue

[Term]
id: MOD:01099
name: succinyl beta-aspartyl anhydride
def: "A protein modification that effectively converts an L-aspartic acid residue to succinyl beta-aspartyl anhydride." [DeltaMass:244]
comment: From DeltaMass with no citation (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 198 Formula: C8H8O1N5 Monoisotopic Mass Change: 198.04 Average Mass Change: 198.156 [JSG].
synonym: "succinyl aspartamyl" EXACT DeltaMass-label []
xref: DiffAvg: "82.06"
xref: DiffFormula: "C 4 H 2 N 0 O 2"
xref: DiffMono: "82.005479"
xref: Formula: "C 8 H 8 N 1 O 5"
xref: MassAvg: "198.15"
xref: MassMono: "198.040247"
xref: Origin: "D"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:01100
name: HMP (hydroxymethylphenyl)/TFA adduct
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 201 with no citation.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01101
name: S-Farnesyl-
def: "OBSOLETE because erroneous and apparently redundant to MOD:00111. Remap to MOD:00111." [DeltaMass:0]
comment: Modification from DeltaMass: Average Mass: 206. This entry with no other information available appears to be the same as the entry at 204 for "Farnesylation" but with an incorrect mass.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:00111"
is_obsolete: true

[Term]
id: MOD:01102
name: myristoylation-4H (two double bonds)
def: "OBSOLETE because redundant and identical to MOD:00504. Remap to MOD:00504." [DeltaMass:348]
comment: From DeltaMass: Average Mass: 206 Formula: C14 H22 O1 Monoisotopic Mass Change: 206.167 Average Mass Change: 206.324 References: Neubert TA, Johnson RS, Hurley JB, Walsh KA (1992). The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated. J Biol Chem. 267(26), 18274-7. Notes: Modification of protein N-terminus with (cis,cis-delta 5, delta 8)-tetradecadienoyl group (myristoylation with 2 double bonds)
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:00504"
is_obsolete: true

[Term]
id: MOD:01103
name: myristoleylation (one double bond)
def: "OBSOLETE because redundant and identical to MOD:00503. Remap to MOD:00503." [DeltaMass:0]
comment: From DeltaMass with no citation or formula: Average Mass: 208.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:00503"
is_obsolete: true

[Term]
id: MOD:01104
name: 4-methoxy-2,3,6-trimethylbenzenesulfonyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 212 with no citation.
synonym: "Mtr" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01105
name: 2-bromobenzyloxycarbonyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 213 with no citation.
synonym: "BrZ" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01106
name: N-formyl-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to N-formyl-L-tryptophan." [DeltaMass:0]
comment: From DeltaMass with no citation or formula: Average Mass: 214. It is not clear what this is supposed to represent. The mass corresponds to an N-formyl tryptophan (either N2 or N1'), but neither of these modifications has been reported as commonly encountered. It may have been confused with N'-formyl-L-kynurenine, see MOD:00464 [JSG]
synonym: "formyl tryptophanyl" EXACT DeltaMass-label []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 H 0 N 0 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "C 12 H 10 N 2 O 2"
xref: MassAvg: "214.22"
xref: MassMono: "214.074228"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00409 ! N-formylated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:01107
name: O5-benzyl-L-glutamate
def: "A protein modification that effectively converts an L-glutamic acid residue to O5-benzyl-L-glutamate." [DeltaMass:258]
comment: From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG].
xref: DiffAvg: "90.13"
xref: DiffFormula: "C 7 H 6"
xref: DiffMono: "90.046950"
xref: Formula: "C 12 H 13 N 1 O 3"
xref: MassAvg: "219.24"
xref: MassMono: "219.089543"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00906 ! modified L-glutamic acid residue
is_a: MOD:01008 ! benzyl (Bzl) and benzyl ester (OBzl) modified residue

[Term]
id: MOD:01108
name: 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid (Glu)
def: "A protein modification that effectively converts an L-glutamic acid residue to 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid, glutamtic acid anisole adduct." [DeltaMass:259]
comment: From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG].
synonym: "anisole adducted glutamyl" EXACT DeltaMass-label []
xref: DiffAvg: "90.13"
xref: DiffFormula: "C 7 H 6"
xref: DiffMono: "90.046950"
xref: Formula: "C 12 H 13 N 1 O 3"
xref: MassAvg: "219.24"
xref: MassMono: "219.089543"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00906 ! modified L-glutamic acid residue
is_a: MOD:01007 ! anisyl modified residue

[Term]
id: MOD:01109
name: 9-fluorenylmethyloxycarbonyl (Fmoc)
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 222 with no citation.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01110
name: isoprenylated cysteine
def: "A protein modification that effectively replaces a hydrogen atom of an L-cysteine residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20)." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "IpCys" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00703 ! isoprenylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01111
name: dimethoxybenzhydryl modified residue
def: "A protein modification that effectively substitutes a dimethoxybenzhydryl group for a hydrogen atom." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 226 with no citation. A reagent, typically 4,4'-dimethoxybenzhydryl chloride, used as a protecting group for the carboxamido group of asparagine and glutamine during chemical peptide synthesis [JSG].
synonym: "4,4'-dimethoxybenzhydryl" EXACT PSI-MOD-alternate []
synonym: "bis(4-methoxyphenyl)methyl" EXACT PSI-MOD-alternate []
synonym: "Mbh" EXACT DeltaMass-label []
xref: DiffAvg: "226.27"
xref: DiffFormula: "C 15 H 14 O 2"
xref: DiffMono: "226.099380"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01112
name: nicotinoyl lysine
def: "modification from DeltaMass" [DeltaMass:266]
comment: From DeltaMass: (name misspelled "nicotinyl"; formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 233 Formula: C12H15O3N2 Monoisotopic Mass Change: 233.116 Average Mass Change: 233.271
synonym: "nicotinyl lysyl" EXACT DeltaMass-label []
xref: DiffAvg: "105.10"
xref: DiffFormula: "C 6 H 3 N 1 O 1"
xref: DiffMono: "105.021464"
xref: Formula: "C 12 H 15 N 3 O 2"
xref: MassAvg: "233.27"
xref: MassMono: "233.116427"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01113
name: 2-(p-biphenyl)isopropyl-oxycarbonyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 238 with no citation.
synonym: "Bpoc" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01114
name: triphenylmethyl
def: "modification from DeltaMass" [DeltaMass:270]
comment: From DeltaMass: Average Mass: 242 Average Mass Change: 242.3 Notes: blocking group used in peptide synthesis for C,H,Q,N
synonym: "Trityl" EXACT DeltaMass-label []
synonym: "Trt" EXACT DeltaMass-label []
xref: DiffAvg: "242.32"
xref: DiffFormula: "C 19 H 14"
xref: DiffMono: "242.109550"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01115
name: isoprenylated tryptophan
def: "A protein modification that effectively replaces a hydrogen atom of an L-tryptophan residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20)." [PubMed:18688235]
synonym: "IpTrp" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "W"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00703 ! isoprenylated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:01116
name: S-farnesyl-L-cysteine methyl ester
def: "A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester." [PubMed:15609361, RESID:AA0102#var, RESID:AA0105#var]
subset: PSI-MOD-slim
synonym: "SFarnOMeCys" EXACT PSI-MOD-label []
xref: DiffAvg: "218.38"
xref: DiffFormula: "C 16 H 26 N 0 O 0 S 0"
xref: DiffMono: "218.203451"
xref: Formula: "C 19 H 32 N 1 O 2 S 1"
xref: MassAvg: "338.53"
xref: MassMono: "338.215375"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00905 ! modified L-cysteine residue
relationship: has_functional_parent MOD:00111 ! S-farnesyl-L-cysteine
relationship: has_functional_parent MOD:00114 ! L-cysteine methyl ester

[Term]
id: MOD:01117
name: pentamethyldihydrobenzofuransulfonyl
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 252 with no citation.
synonym: "Pbf" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01118
name: alpha-N-6-phosphogluconoylated L-histidine
def: "A protein modification that effectively replaces the N-terminal hydrogen atom of a N-terminal histidine residue with a 6-phosphogluconoyl group linked through a glycosidic bond. modification from DeltaMass" [PubMed:9918669, DeltaMass:275]
comment: Occurs on His-tagged proteins expresssed in E. coli.From DeltaMass: Average Mass: 258 Formula: C6H10O6HPO3 Monoisotopic Mass Change: 258.01 Average Mass Change: 258.12 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84. Mass is one Da higher because this is an N-terminal modification
xref: DiffAvg: "259.12"
xref: DiffFormula: "C 6 H 12 O 9 P 1"
xref: DiffMono: "259.021894"
xref: Formula: "C 12 H 19 N 3 O 10 P 1"
xref: MassAvg: "396.27"
xref: MassMono: "396.080806"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:00006 ! N-glycosylated residue

[Term]
id: MOD:01119
name: S-geranylgeranyl-L-cysteine methyl ester
def: "A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine methyl ester." [PubMed:1483450, PubMed:15609361, RESID:AA0104#var, RESID:AA0105#var]
subset: PSI-MOD-slim
synonym: "SGergerOMeCys" EXACT PSI-MOD-label []
xref: DiffAvg: "286.50"
xref: DiffFormula: "C 21 H 34 N 0 O 0 S 0"
xref: DiffMono: "286.266051"
xref: Formula: "C 24 H 40 N 1 O 2 S 1"
xref: MassAvg: "406.65"
xref: MassMono: "406.277976"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00905 ! modified L-cysteine residue
relationship: has_functional_parent MOD:00113 ! S-geranylgeranyl-L-cysteine
relationship: has_functional_parent MOD:00114 ! L-cysteine methyl ester

[Term]
id: MOD:01120
name: 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue
def: "A protein modification that is produced by formation of an adduct with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 266 Notes: blocking group for Arg in peptide synthesis. CAS:112160-39-1 [JSG].
synonym: "2,2,5,7,8-pentamethyl-3,4-dihydro-2H-chromene-6-sulfonyl" EXACT PSI-MOD-alternate []
synonym: "2,2,5,7,8-pentamethyl-6-chromansulfonyl" EXACT PSI-MOD-alternate []
synonym: "2,2,5,7,8-pentamethyl-chromane-6-sulfonyl" EXACT PSI-MOD-alternate []
synonym: "2,2,5,7,8-pentamethylchroman-6-sulfonyl" EXACT PSI-MOD-alternate []
synonym: "2,2,5,7,8-pentamethylchroman-6-sulphonyl" EXACT PSI-MOD-alternate []
synonym: "3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-sulfonyl" EXACT PSI-MOD-alternate []
synonym: "Pmc" EXACT DeltaMass-label []
synonym: "PmcRes" EXACT PSI-MOD-label []
xref: DiffAvg: "266.36"
xref: DiffFormula: "C 14 H 18 O 3 S 1"
xref: DiffMono: "266.097665"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue

[Term]
id: MOD:01121
name: monomethoxytrityl
def: "modification from DeltaMass" [DeltaMass:280]
comment: From DeltaMass: Average Mass: 272 Average Mass Change: 272
synonym: "Mmt" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01122
name: 5'phos dCytidinyl
def: "OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 289 with no citation.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:01123
name: monoiodated tyrosine
def: "OBSOLETE because redundant and identical to MOD:01123. Remap to MOD:01123." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 289
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "Y"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:01123"
is_obsolete: true

[Term]
id: MOD:01124
name: aldohexosyl lysyl
def: "modification from DeltaMass" [DeltaMass:285]
comment: From DeltaMass: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 290 Formula: C12H22O2N6 Monoisotopic Mass Change: 290.148 Average Mass Change: 290.317
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 N 0 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 12 H 22 N 2 O 6"
xref: MassAvg: "290.32"
xref: MassMono: "290.147786"
xref: Origin: "K"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01125
name: 5'phos dThymidinyl
def: "OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 304 with no citation.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:01126
name: 5'phos Cytidinyl
def: "OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 305 with no citation.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:01127
name: 5'phos Uridinyl
def: "OBSOLETE because redundant and identical to MOD:01166. Remap to MOD:01166." [DeltaMass:292]
comment: From DeltaMass: Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:01166"
is_obsolete: true

[Term]
id: MOD:01128
name: N-glycolneuraminic acid
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 307 with no citation.
synonym: "NeuGc" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01129
name: 5'phos dAdenosyl
def: "OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass" [DeltaMass:295]
comment: From DeltaMass: Average Mass: 313 Formula: C10H12O5N5P1 Monoisotopic Mass Change: 313.058 Average Mass Change: 313.211
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:01130
name: SucPhencarb Lysyl
def: "modification from DeltaMass" [DeltaMass:297]
comment: From DeltaMass: Average Mass: 327 Formula: C17H17O3N4 Monoisotopic Mass Change: 327.122 Average Mass Change: 327.342
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01131
name: 5'phos dGuanosyl
def: "OBSOLETE because this is a modification that occurs to DNA/RNA and not proteins. modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 329
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:01132
name: 5'phos Adenosinyl
def: "OBSOLETE because redundant and identical to MOD:01165. Remap to MOD:01165." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 329
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:01165"
is_obsolete: true

[Term]
id: MOD:01133
name: S-12-hydroxyfarnesyl-L-cysteine methyl ester
def: "A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine methyl ester." [PubMed:17790543, RESID:AA0103#var, RESID:AA0105#var]
synonym: "S12HyFarnOMeCys" EXACT PSI-MOD-label []
xref: DiffAvg: "234.38"
xref: DiffFormula: "C 16 H 26 N 0 O 1 S 0"
xref: DiffMono: "234.198365"
xref: Formula: "C 19 H 32 N 1 O 3 S 1"
xref: MassAvg: "354.53"
xref: MassMono: "354.210290"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00905 ! modified L-cysteine residue
relationship: has_functional_parent MOD:00112 ! S-12-hydroxyfarnesyl-L-cysteine
relationship: has_functional_parent MOD:00114 ! L-cysteine methyl ester

[Term]
id: MOD:01134
name: fluorescein labelling of peptide N-terminal using NHS ester
def: "modification from DeltaMass" [DeltaMass:306]
comment: From DeltaMass: Average Mass: 359 Formula: C21H11O6 Monoisotopic Mass Change: 359.055 Average Mass Change: 359.315 Notes: Using the DHB matrix at low pH the carboxyl group and one of the oxygens on the flurorescein molecule are protinated so the delta mass is 2Da higher than most text book illustrations would indicate. See Bioconjugate Techniques by Greg Hermanson, Academic Press, page 305, figure 204. Text books of course just show the coupling reaction at neutral or basic pH.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01135
name: Hex-HexNAc
def: "modification from DeltaMass" [DeltaMass:0]
comment: From DeltaMass: Average Mass: 365 with no citation.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00947 ! DeltaMass

[Term]
id: MOD:01136
name: dioctyl phthalate
def: "OBSOLETE because this is a small molecule contaminant and not a modification to a polypeptide. modification from DeltaMass" [DeltaMass:309]
comment: From DeltaMass: Average Mass: 391 Average Mass Change: 391 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:01137
name: N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine
def: "A protein modification that is produced by reaction of a lysine residue with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine." [DeltaMass:310]
comment: From DeltaMass: Average Mass: Formula: C20H30O2N4S1 Monoisotopic Mass Change: 394.192 Average Mass Change: 394.534
synonym: "PMC lysyl" EXACT DeltaMass-label []
synonym: "PmcLys" EXACT PSI-MOD-label []
xref: DiffAvg: "266.36"
xref: DiffFormula: "C 14 H 18 O 3 S 1"
xref: DiffMono: "266.097665"
xref: Formula: "C 20 H 30 N 2 O 4 S 1"
xref: MassAvg: "394.53"
xref: MassMono: "394.192628"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00902 ! modified L-arginine residue
is_a: MOD:01120 ! 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue

[Term]
id: MOD:01138
name: Aedans Cystenyl
def: "OBSOLETE because no evidence has been seen for this protein modification. modification from DeltaMass" [DeltaMass:311]
comment: [probably aminoethyldansyl, JSG] From DeltaMass: (name misspelled "Aedans Cystenyl", and formula incorrect, N and O reversed) Average Mass: 409 Abbreviation: Aedans-Cys Formula: C17H19O3N5S2 Monoisotopic Mass Change: 409.077 Average Mass Change: 409.482
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:01139
name: dioctyl phthalate sodium adduct
def: "OBSOLETE because this is a MS contaminant, not a known modification to a polypeptide. modification from DeltaMass" [DeltaMass:312]
comment: From DeltaMass: Mass: Average Mass Change: 413 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "artifact"
xref: TermSpec: "none"
is_obsolete: true

[Term]
id: MOD:01140
name: diiodinated tyrosine
def: "A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two iodine atoms." [DeltaMass:0, OMSSA:35, PubMed:15627961, Unimod:130#Y]
subset: PSI-MOD-slim
synonym: "3,5-Diiodination (of Tyrosine)" EXACT DeltaMass-label []
synonym: "di-Iodination" RELATED Unimod-description []
synonym: "diiodinationy" EXACT OMSSA-label []
synonym: "Diiodo" RELATED PSI-MS-label []
synonym: "I2Tyr" EXACT PSI-MOD-label []
xref: DiffAvg: "251.79"
xref: DiffFormula: "C 0 H -2 I 2 N 0 O 0"
xref: DiffMono: "251.793295"
xref: Formula: "C 9 H 7 I 2 N 1 O 2"
xref: MassAvg: "414.97"
xref: MassMono: "414.856624"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:130"
is_a: MOD:00501 ! diiodinated residue
is_a: MOD:00998 ! iodinated tyrosine

[Term]
id: MOD:01141
name: omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine
def: "A protein modification that is produced by reaction with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine." [DeltaMass:314]
comment: From DeltaMass: Average Mass: Formula: C20H30O4N4S1 Monoisotopic Mass Change: 422.199 Average Mass Change: 422.547
synonym: "PMC arginyl" EXACT DeltaMass-label []
synonym: "PmcArg" EXACT PSI-MOD-label []
xref: DiffAvg: "266.36"
xref: DiffFormula: "C 14 H 18 O 3 S 1"
xref: DiffMono: "266.097665"
xref: Formula: "C 20 H 30 N 4 O 4 S 1"
xref: MassAvg: "422.54"
xref: MassMono: "422.198776"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00902 ! modified L-arginine residue
is_a: MOD:01120 ! 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue

[Term]
id: MOD:01142
name: S-15,16-dihydrobiliverdin-L-cysteine
def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound 15,16-dihydrobiliverdin." [PubMed:10430868, PubMed:15504407, PubMed:1559975, PubMed:3208761, RESID:AA0428]
synonym: "(16R)-18-ethenyl-8,12-bis(2-carboxyethyl)-3-[(1R)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione" EXACT RESID-systematic []
synonym: "15,16-Dhbv" EXACT RESID-alternate []
synonym: "15,16-dihydrobiliverdin cysteine adduct" EXACT RESID-alternate []
synonym: "15,16-dihydrobiliverdin IXalpha" EXACT RESID-alternate []
synonym: "18-ethenyl-8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione" EXACT RESID-alternate []
synonym: "3'-cysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate []
synonym: "3alpha-cysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate []
synonym: "BINDING 15,16-dihydrobiliverdin (covalent; via 1 link)" EXACT UniProt-feature []
synonym: "DBV" EXACT RESID-alternate []
synonym: "S-15,16-dihydrobiliverdin-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "584.67"
xref: DiffFormula: "C 33 H 36 N 4 O 6 S 0"
xref: DiffMono: "584.263485"
xref: Formula: "C 36 H 41 N 5 O 7 S 1"
xref: MassAvg: "687.81"
xref: MassMono: "687.272670"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00700 ! tetrapyrrole modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01143
name: 15,16-dihydrobiliverdin-bis-L-cysteine
def: "A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound 15,16-dihydrobiliverdin." [PubMed:1559975, PubMed:2222853, PubMed:3208761, PubMed:8420941, RESID:AA0429]
comment: Cross-link 2.
synonym: "(16R)-8,12-bis(2-carboxyethyl)-3-[2-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-18-[(1Xi)-1-(((2R)-2-amino-2-carboxy)ethylsulfanyl)ethyl]-2,7,13,17-tetramethyl-15,16-dihydrobilin-1,19(21H,24H)-dione" EXACT RESID-systematic []
synonym: "15,16-Dhbv" EXACT RESID-alternate []
synonym: "15,16-dihydrobiliverdin cysteine adduct" EXACT RESID-alternate []
synonym: "15,16-dihydrobiliverdin IXalpha" EXACT RESID-alternate []
synonym: "15,16-dihydrobiliverdin-bis-L-cysteine" EXACT RESID-name []
synonym: "3'',18'-biscysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate []
synonym: "3beta,18alpha-biscysteinyl-15,16-dihydrobiliverdin" EXACT RESID-alternate []
synonym: "8,12-bis(2-carboxyethyl)-3-(2-(cysteinyl-S)-ethyl)-18-(1-(cysteinyl-S)-ethyl)-2,7,13,17-tetramethylbiladiene-ab-1,19(16H,21H)-dione" EXACT RESID-alternate []
synonym: "BINDING  15,16-dihydrobiliverdin (covalent; via 2 links)" EXACT UniProt-feature []
synonym: "DBV" EXACT RESID-alternate []
xref: DiffAvg: "584.67"
xref: DiffFormula: "C 33 H 36 N 4 O 6 S 0"
xref: DiffMono: "584.263485"
xref: Formula: "C 39 H 46 N 6 O 8 S 2"
xref: MassAvg: "790.95"
xref: MassMono: "790.281854"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00700 ! tetrapyrrole modified residue
is_a: MOD:02044 ! crosslinked L-cysteine residue

[Term]
id: MOD:01144
name: S-(sn-1-2,3-dipalmitoylglycerol)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine." [DeltaMass:0, PubMed:10896212, PubMed:4575979, PubMed:9056182, RESID:AA0107#var]
comment: From DeltaMass: Average Mass: 524
subset: PSI-MOD-slim
synonym: "S-(sn-1-Dipalmitoyl-glyceryl)- (on Cysteine)" EXACT DeltaMass-label []
xref: DiffAvg: "550.91"
xref: DiffFormula: "C 35 H 66 N 0 O 4 S 0"
xref: DiffMono: "550.496111"
xref: Formula: "C 38 H 71 N 1 O 5 S 1"
xref: MassAvg: "654.05"
xref: MassMono: "653.505295"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00116 ! S-diacylglycerol-L-cysteine

[Term]
id: MOD:01145
name: N-tau-(ADP-ribosyl)diphthamide
def: "A protein modification that effectively converts an L-histidine residue to N-tau-(ADP-ribosyl)diphthamide." [DeltaMass:0, ChEBI:82697]
comment: From DeltaMass: (name misspelled "N theta -(ADP-ribosyl) diphthamide (of Histidine)") Average Mass: 648
synonym: "MOD_RES ADP-ribosyldiphthamide" EXACT UniProt-feature []
xref: DiffAvg: "684.51"
xref: DiffFormula: "C 22 H 36 N 7 O 14 P 2"
xref: DiffMono: "684.178999"
xref: FormalCharge: "1+"
xref: Formula: "C 28 H 43 N 10 O 15 P 2"
xref: MassAvg: "821.65"
xref: MassMono: "821.237910"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0672
is_a: MOD:02087 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue
is_a: MOD:00909 ! modified L-histidine residue
relationship: derives_from MOD:00049 ! 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine

[Term]
id: MOD:01146
name: S-(6-FAD)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(6-FAD)-L-cystine." [DeltaMass:0]
comment: From DeltaMass: Average Mass: 784 with no citation. This modification has not been reported [JSG].
subset: PSI-MOD-slim
synonym: "FAD" RELATED PSI-MS-label []
synonym: "S6FADCys" EXACT PSI-MOD-label []
xref: DiffAvg: "783.54"
xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2 S 0"
xref: DiffMono: "783.141485"
xref: Formula: "C 30 H 36 N 10 O 16 P 2 S 1"
xref: MassAvg: "886.68"
xref: MassMono: "886.150669"
xref: Origin: "C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00895 ! FAD modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01147
name: dHex1Hex3HexNAc2 N4-glycosylated asparagine
def: "modification from DeltaMass" [DeltaMass:0, Unimod:1761]
comment: From DeltaMass: Average Mass: 1,039
xref: DiffAvg: "1038.95"
xref: DiffFormula: "C 40 H 66 N 2 O 29"
xref: DiffMono: "1038.375124"
xref: Formula: "C 44 H 72 N 4 O 31"
xref: MassAvg: "1153.06"
xref: MassMono: "1152.418052"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1761"
xref: GNOme: "GNO:G20956ZV"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:01148
name: ubiquitinylated lysine
def: "A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin." [PubMed:11125103, PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01875 ! N6-acylated L-lysine
relationship: contains MOD:00134 ! N6-glycyl-L-lysine

[Term]
id: MOD:01149
name: sumoylated lysine
def: "A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein." [PubMed:12612601, PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01875 ! N6-acylated L-lysine
relationship: contains MOD:00134 ! N6-glycyl-L-lysine

[Term]
id: MOD:01150
name: neddylated lysine
def: "A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein." [PubMed:11125103, PubMed:12612601, PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:01875 ! N6-acylated L-lysine
relationship: contains MOD:00134 ! N6-glycyl-L-lysine

[Term]
id: MOD:01151
name: phosphorylated residue with neutral loss of phosphate
def: "Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid phosphorylated residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment." [PubMed:18688235]
subset: PSI-MOD-slim
xref: DiffAvg: "-97.99"
xref: DiffFormula: "C 0 H -3 N 0 O -4 P -1"
xref: DiffMono: "-97.976895"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00432 ! modified residue with neutral loss of phosphate

[Term]
id: MOD:01152
name: carboxylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a carboxylic acid group." [Unimod:299]
subset: PSI-MOD-slim
synonym: "Carboxy" RELATED Unimod-interim []
synonym: "Carboxylation" RELATED Unimod-description []
xref: DiffAvg: "44.01"
xref: DiffFormula: "C 1 H 0 N 0 O 2"
xref: DiffMono: "43.989829"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:299"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:01153
name: methylthiolated residue
def: "A protein modification that effectively replaces a hydrogen atom with an methylsulfanyl group (thiomethyl group)." [Unimod:39]
subset: PSI-MOD-slim
synonym: "Beta-methylthiolation" RELATED Unimod-description []
synonym: "Methylthio" RELATED Unimod-interim []
xref: DiffAvg: "46.09"
xref: DiffFormula: "C 1 H 2 N 0 O 0 S 1"
xref: DiffMono: "45.987721"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:39"
is_a: MOD:01886 ! thiolated residue

[Term]
id: MOD:01154
name: pyruvic acid
def: "A protein modification that effectively converts a source amino acid to pyruvic acid." [PubMed:10085076, PubMed:3042771, PubMed:8464063, RESID:AA0127]
subset: PSI-MOD-slim
synonym: "2-oxopropanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES Pyruvic acid (Cys)" EXACT UniProt-feature []
synonym: "MOD_RES Pyruvic acid (Ser)" EXACT UniProt-feature []
synonym: "pyruvic acid" EXACT RESID-name []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 3 H 3 O 2"
xref: MassAvg: "71.06"
xref: MassMono: "71.013304"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "N-term"
is_a: MOD:00769 ! residues isobaric at 71.0-71.1 Da
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:01155
name: lipoconjugated residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a lipid-like group either through acylation, alkylation, or amidation." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:01156
name: protein modification categorized by chemical process
def: "Modified amino acid residue derived from a natural amino acid by a real or hypothetical chemical process." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00000 ! protein modification

[Term]
id: MOD:01157
name: protein modification categorized by amino acid modified
def: "A protein modification considered either as modified amino acid residues derived from natural amino acids, as a replacement by another natural amino acid, or as a replacement by an unnatural amino acid." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00000 ! protein modification

[Term]
id: MOD:01158
name: modified L-selenocysteine residue
def: "A protein modification that modifies an L-selenocysteine residue." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "U"
is_a: MOD:00745 ! selenium containing residue
is_a: MOD:01157 ! protein modification categorized by amino acid modified
relationship: derives_from MOD:00031 ! L-selenocysteine residue

[Term]
id: MOD:01159
name: peptidoglycanated residue
def: "A protein modification that effectively attaches a residue to murein peptidoglycan by either a pentaglycine linker peptide or a peptide-like L-alanyl-D-glutamyl-2,6-diaminopimelic acid linkage." [PubMed:18688235]
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00764 ! glycoconjugated residue

[Term]
id: MOD:01160
name: deaminated residue
def: "A protein modification that effectively results in the loss of an ammonia, usually by a process of vicinal dehydration, rearrangement, and rehydration with release of ammonia, resulting in a loss of nitrogen with no gain of oxygen." [Unimod:385]
subset: PSI-MOD-slim
synonym: "Ammonia-loss" RELATED Unimod-interim []
synonym: "Loss of ammonia" RELATED Unimod-description []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:385"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:01161
name: deoxygenated residue
def: "A protein modification that effectively removes oxygen atoms from a residue without the removal of hydrogen atoms." [PubMed:14235557, Unimod:447]
subset: PSI-MOD-slim
synonym: "Deoxy" RELATED PSI-MS-label []
synonym: "dOxyRes" EXACT PSI-MOD-label []
synonym: "reduction" RELATED Unimod-description []
xref: DiffAvg: "-16.00"
xref: DiffFormula: "C 0 H 0 N 0 O -1"
xref: DiffMono: "-15.994915"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:447"
is_a: MOD:01472 ! reduced residue

[Term]
id: MOD:01162
name: fucosylated biantennary
def: "modification from Unimod N-linked glycosylation" [Unimod:308]
synonym: "dHex(1)Hex(5)HexNAc(4)" RELATED PSI-MS-label []
synonym: "Fucosylated biantennary" RELATED Unimod-description []
xref: DiffAvg: "1769.62"
xref: DiffFormula: "C 68 H 112 N 4 O 49"
xref: DiffMono: "1768.639516"
xref: Formula: "C 72 H 118 N 6 O 51"
xref: MassAvg: "1883.73"
xref: MassMono: "1882.682443"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:308"
xref: GNOme: "GNO:G83555HU"
is_a: MOD:00725 ! complex glycosylation

[Term]
id: MOD:01163
name: guanylated residue
def: "A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoguanosine through either a phosphodiester or a phosphoramide bond." [DeltaMass:304, Unimod:413]
comment: From DeltaMass: (formula incorrect, N and O reversed) Average Mass: 345 Formula: C10H12O5N7P1 Monoisotopic Mass Change: 345.047 Average Mass Change: 345.209.
synonym: "5'phos Guanosyl" EXACT DeltaMass-label []
synonym: "phospho-guanosine" RELATED Unimod-description []
synonym: "Phosphoguanosine" RELATED PSI-MS-label []
xref: DiffAvg: "345.21"
xref: DiffFormula: "C 10 H 12 N 5 O 7 P 1"
xref: DiffMono: "345.047434"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:413"
is_a: MOD:00701 ! nucleotide or nucleic acid modified residue

[Term]
id: MOD:01164
name: riboflavin-phosphorylated residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through a phosphodiester bond." [Unimod:442]
subset: PSI-MOD-slim
synonym: "FMN" RELATED PSI-MS-label []
synonym: "O3-(riboflavin phosphoryl)" RELATED Unimod-description []
xref: DiffAvg: "438.33"
xref: DiffFormula: "C 17 H 19 N 4 O 8 P 1"
xref: DiffMono: "438.094050"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:442"
is_a: MOD:00697 ! flavin modified residue

[Term]
id: MOD:01165
name: adenylated residue
def: "A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoadenosine through either a phosphodiester or a phosphoramide bond." [DeltaMass:0, Unimod:405]
comment: From DeltaMass: (name misspelled "5'phos adenosinyl") Average Mass: 329
subset: PSI-MOD-slim
synonym: "5'phos Adenosinyl" EXACT DeltaMass-label []
synonym: "AMP binding site" RELATED Unimod-description []
synonym: "Phosphoadenosine" RELATED PSI-MS-label []
xref: DiffAvg: "329.21"
xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1"
xref: DiffMono: "329.052520"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:405"
is_a: MOD:00701 ! nucleotide or nucleic acid modified residue

[Term]
id: MOD:01166
name: uridylated residue
def: "A protein modification that effectively crosslinks an amino acid residue and 5'-phosphouridine through either a phosphodiester or a phosphoramide bond." [DeltaMass:292, Unimod:417]
comment: From DeltaMass: (name misspelled "5'phos Uridinyl" and formula incorrect, N and O reversed) Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17
synonym: "5'phos Uridinyl" EXACT DeltaMass-label []
synonym: "PhosphoUridine" RELATED PSI-MS-label []
synonym: "uridine phosphodiester" RELATED Unimod-description []
xref: DiffAvg: "306.17"
xref: DiffFormula: "C 9 H 11 N 2 O 8 P 1"
xref: DiffMono: "306.025302"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:417"
is_a: MOD:00701 ! nucleotide or nucleic acid modified residue

[Term]
id: MOD:01167
name: molybdopterin guanine dinucleotide
def: "modification from Unimod" [Unimod:424]
synonym: "molybdenum bis(molybdopterin guanine dinucleotide)" RELATED Unimod-description []
synonym: "MolybdopterinGD" RELATED PSI-MS-label []
xref: DiffAvg: "1572.02"
xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 4"
xref: DiffMono: "1572.985775"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:424"
is_a: MOD:00744 ! molybdenum pterin containing modification

[Term]
id: MOD:01168
name: dehydroalanine
def: "A protein modification that effectively converts a source amino acid residue to dehydroalanine." [PubMed:10220322, PubMed:1547888, PubMed:1815586, PubMed:2914619, PubMed:6838602, PubMed:7947813, PubMed:8239649, RESID:AA0181]
subset: PSI-MOD-slim
synonym: "2,3-didehydroalanine" EXACT RESID-alternate []
synonym: "2-aminoacrylic acid" EXACT RESID-alternate []
synonym: "2-aminopropenoic acid" EXACT RESID-systematic []
synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate []
synonym: "anhydroserine" EXACT RESID-alternate []
synonym: "dehydroalanine" EXACT RESID-name []
synonym: "Dha" EXACT RESID-alternate []
synonym: "dHAla" EXACT PSI-MOD-label []
synonym: "MOD_RES 2,3-didehydroalanine (Cys)" EXACT UniProt-feature []
synonym: "MOD_RES 2,3-didehydroalanine (Ser)" EXACT UniProt-feature []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 3 H 3 N 1 O 1"
xref: MassAvg: "69.06"
xref: MassMono: "69.021464"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:01169
name: L-3-oxoalanine
def: "A protein modification that effectively converts a source amino acid residue to L-oxoalanine." [DeltaMass:349, PubMed:14563551, PubMed:7628016, PubMed:8681943, PubMed:9478923, RESID:AA0185]
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-oxopropanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-oxopropionic acid" EXACT RESID-alternate []
synonym: "C(alpha)-formylglycine" RELATED RESID-misnomer []
synonym: "L-3-oxoalanine" EXACT RESID-name []
synonym: "L-amino-malonic acid semialdehyde" EXACT RESID-alternate []
synonym: "L-aminomalonaldehydic acid" EXACT RESID-alternate []
synonym: "L-serinesemialdehyde" RELATED RESID-misnomer []
synonym: "MOD_RES 3-oxoalanine (Cys)" EXACT UniProt-feature []
synonym: "MOD_RES 3-oxoalanine (Ser)" EXACT UniProt-feature []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 3 H 3 N 1 O 2"
xref: MassAvg: "85.06"
xref: MassMono: "85.016378"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:01170
name: pyruvic acid iminylated residue
def: "A protein modification that effectively forms a 2-ketoimine of pyruvicacid with a residue amino group." [Unimod:422]
synonym: "N-pyruvic acid 2-iminyl" RELATED Unimod-description []
synonym: "PyruvicAcidIminyl" RELATED PSI-MS-label []
xref: DiffAvg: "70.05"
xref: DiffFormula: "C 3 H 2 N 0 O 2"
xref: DiffMono: "70.005479"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:422"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:01171
name: O-acetyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-acetyl-L-threonine." [PubMed:16728640, RESID:AA0423, Unimod:1#T]
subset: PSI-MOD-slim
synonym: "(2S,3R)-3-(acetyloxy)-2-aminobutanoic acid" EXACT RESID-systematic []
synonym: "Acetylation" RELATED Unimod-description []
synonym: "ACT_SITE O-acetylthreonine intermediate" EXACT UniProt-feature []
synonym: "MOD_RES O-acetylthreonine" EXACT UniProt-feature []
synonym: "O-acetyl-L-threonine" EXACT RESID-name []
synonym: "O-acetylthreonine" EXACT RESID-alternate []
synonym: "OAcThr" EXACT PSI-MOD-label []
synonym: "threonine acetate ester" EXACT RESID-alternate []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "C 6 H 9 N 1 O 3"
xref: MassAvg: "143.14"
xref: MassMono: "143.058243"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1"
xref: uniprot.ptm:PTM-0233
is_a: MOD:00644 ! mono O-acetylated residue
is_a: MOD:01186 ! monoacetylated L-threonine

[Term]
id: MOD:01172
name: N-alanyl-glycosylsphingolipidinositolethanolamine
def: "A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, RESID:AA0424]
synonym: "GSIAla" EXACT PSI-MOD-label []
synonym: "LIPID GPI-like-anchor amidated alanine" EXACT UniProt-feature []
synonym: "N-alanyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 5 H 12 N 2 O 5 P 1"
xref: MassAvg: "211.13"
xref: MassMono: "211.048383"
xref: Origin: "A"
xref: Source: "hypothetical"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0144
is_a: MOD:00466 ! glycosylsphingolipidinositolated residue
is_a: MOD:00901 ! modified L-alanine residue

[Term]
id: MOD:01173
name: N-asparaginyl-glycosylsphingolipidinositolethanolamine
def: "A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylsphingolipidinositolethanolamine." [PubMed:12626404, RESID:AA0425]
synonym: "GSIAsn" EXACT PSI-MOD-label []
synonym: "LIPID GPI-like-anchor amidated asparagine" EXACT UniProt-feature []
synonym: "N-asparaginyl-glycosylsphingolipidinositolethanolamine" EXACT RESID-name []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 6 H 13 N 3 O 6 P 1"
xref: MassAvg: "254.16"
xref: MassMono: "254.054197"
xref: Origin: "N"
xref: Source: "hypothetical"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0145
is_a: MOD:00466 ! glycosylsphingolipidinositolated residue
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:01174
name: S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine." [ChEBI:27485, PubMed:11466314, PubMed:12684535, RESID:AA0426]
synonym: "(2R)-2-amino-3-([(5Z,9Xi,12E,14Z)-1-hydroxy-1,11-oxoprosta-5,12,14-trien-9-yl]sulfanyl)propanoic acid" EXACT RESID-alternate []
synonym: "(5Z,9Xi,12E,14Z)-9-([(2R)-2-amino-3-carboxyethyl]sulfanyl)-11-oxoprosta-5,12,14-trien-1-oic acid" EXACT RESID-systematic []
synonym: "LIPID S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine" EXACT UniProt-feature []
synonym: "PG-J2Cys" EXACT PSI-MOD-label []
synonym: "S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "316.44"
xref: DiffFormula: "C 20 H 28 N 0 O 3 S 0"
xref: DiffMono: "316.203845"
xref: Formula: "C 23 H 33 N 1 O 4 S 1"
xref: MassAvg: "419.58"
xref: MassMono: "419.213030"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0447
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:01175
name: S-phycourobilin-L-cysteine
def: "A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycourobilin." [PubMed:1903388, PubMed:3208761, PubMed:3838747, RESID:AA0427]
synonym: "(2S,3R,16R)-18-ethenyl-3-[(1R)-1-([(R)-2-amino-2-carboxyethyl]sulfanyl)ethyl]-8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-4,5,15,16-tetrahydrobiline-1,19(21H,22H,24H)-dione" EXACT RESID-systematic []
synonym: "18-ethenyl-3-[1-(2-amino-2-carboxyethylsulfanyl)ethyl]-2,3,15,16-dihydro-2,7,13,17-tetramethyl-1,19-dioxo-(21H,22H,24H)-bilin-8,12-dipropanoic acid" EXACT RESID-alternate []
synonym: "BINDING Phycourobilin chromophore (covalent; via 1 link)" EXACT UniProt-feature []
synonym: "phycourobilin cysteine adduct" EXACT RESID-alternate []
synonym: "PUB" EXACT RESID-alternate []
synonym: "PUBCys" EXACT PSI-MOD-label []
synonym: "S-phycourobilin-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "586.69"
xref: DiffFormula: "C 33 H 38 N 4 O 6 S 0"
xref: DiffMono: "586.279135"
xref: Formula: "C 36 H 43 N 5 O 7 S 1"
xref: MassAvg: "689.83"
xref: MassMono: "689.288320"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00700 ! tetrapyrrole modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01176
name: L-dehydrolysinonorleucine
def: "A protein modification that effectively cross-links an L-lysine residue and an L-lysine residue converted to allysine with a carbon-nitrogen bond to form L-dehydrolysinonorleucine." [PubMed:16929109, RESID:AA0430]
comment: Cross-link 2.
synonym: "(2S)-2-amino-6-([(5S)-5-amino-5-carboxypentylidene]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "6-(N6-L-didehydrolysino)-L-norleucine" EXACT RESID-alternate []
synonym: "CROSSLNK Dehydrolysinonorleucine (Lys-Lys)" EXACT UniProt-feature []
synonym: "dehydrolysinorleucine [misspelling]" EXACT RESID-alternate []
synonym: "dehydrolysylnorleucine" EXACT RESID-alternate []
synonym: "didehydrolysinonorleucine" EXACT RESID-alternate []
synonym: "L-dehydrolysinonorleucine" EXACT RESID-name []
synonym: "N6-[(5S)-5-amino-5-carboxypentylidene]-L-lysine" EXACT RESID-alternate []
synonym: "XLNK6NleN6Lys" EXACT PSI-MOD-label []
xref: DiffAvg: "-19.05"
xref: DiffFormula: "C 0 H -5 N -1 O 0"
xref: DiffMono: "-19.042199"
xref: Formula: "C 12 H 19 N 3 O 2"
xref: MassAvg: "237.30"
xref: MassMono: "237.147727"
xref: Origin: "K, K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02051 ! crosslinked L-lysine residue

[Term]
id: MOD:01177
name: 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine." [PubMed:16760471, RESID:AA0431]
synonym: "(S)-2-amino-3-[1-(1,2,3-trihydroxypropan-2-yl)-1H-imidazol-4-yl]propanoic acid" EXACT RESID-systematic []
synonym: "1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine" EXACT RESID-name []
synonym: "1-[1,2-dihydroxy-1-(hydroxymethyl)ethyl]-L-histidine" EXACT RESID-alternate []
synonym: "MOD_RES Tele-(1,2,3-trihydroxypropan-2-yl)histidine" EXACT UniProt-feature []
synonym: "N(epsilon)-histidine dihydroxyacetone adduct" EXACT RESID-alternate []
synonym: "N(tau)-(1,2,3-trihydroxypropan-2-yl)histidine" EXACT RESID-alternate []
synonym: "NtauDHAHis" EXACT PSI-MOD-label []
synonym: "tele-(1,2,3-trihydroxypropan-2-yl)histidine" EXACT RESID-alternate []
xref: DiffAvg: "90.08"
xref: DiffFormula: "C 3 H 6 N 0 O 3"
xref: DiffMono: "90.031694"
xref: Formula: "C 9 H 13 N 3 O 4"
xref: MassAvg: "227.22"
xref: MassMono: "227.090606"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0416
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:01178
name: S-(aspart-4-yloxy) thiocarbonate
def: "A protein modification that effectively converts an L-aspartic acid residue to S-(aspart-4-yloxy) thiocarbonate." [PubMed:16627948, RESID:AA0432]
comment: This modification was originally observed in an Entamoeba histolytica enzyme expressed in Escherichia coli. It was not chemically confirmed or characterized. It did not appear in a later model at higher resolution by the same group. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
synonym: "(2S)-2-amino-4-(carboxysulfanyl)oxy-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "4-aspartyloxysulfanylcarbonate" EXACT RESID-alternate []
synonym: "AspOSCO2H" EXACT PSI-MOD-label []
synonym: "O-carboxysulfanyl-4-oxo-L-homoserine" EXACT RESID-alternate []
synonym: "S-(aspart-4-yloxy) thiocarbonate" EXACT RESID-name []
xref: DiffAvg: "76.07"
xref: DiffFormula: "C 1 H 0 N 0 O 2 S 1"
xref: DiffMono: "75.961900"
xref: Formula: "C 5 H 5 N 1 O 5 S 1"
xref: MassAvg: "191.16"
xref: MassMono: "190.988843"
xref: Origin: "D"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:01179
name: N,N-dimethyl-L-alanine
def: "A protein modification that effectively converts an L-alanine residue to N,N-dimethyl-L-alanine." [PubMed:17691833, PubMed:387091, RESID:AA0433]
synonym: "(S)-1-carboxy-N,N-dimethylaminoethane" EXACT RESID-alternate []
synonym: "(S)-2-(dimethylamino)propanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES N,N-dimethylalanine" EXACT UniProt-feature []
synonym: "N,N-dimethyl-L-alanine" EXACT RESID-name []
synonym: "N,N-dimethylalanine" EXACT RESID-alternate []
synonym: "NMe2Ala" EXACT PSI-MOD-label []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4 N 0 O 0"
xref: DiffMono: "28.031300"
xref: Formula: "C 5 H 10 N 1 O 1"
xref: MassAvg: "100.14"
xref: MassMono: "100.076239"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0178
is_a: MOD:01461 ! N-methylated alanine
is_a: MOD:01686 ! alpha-amino dimethylated residue

[Term]
id: MOD:01180
name: 2-hydroxyglycine observational artifact
def: "A protein modification that effectively converts a glycine residue to 2-hydroxyglycine." [ChEBI:38048, PubMed:16178056, PubMed:17431180, PubMed:17823333, RESID:AA0434]
comment: CAUTION - peptides of 2-hydroxyglycine are known to be unstable, decaying to break the peptide backbone or to form peptidyl amides [see J. Am. Chem. Soc. 111, 1933-1934, 1989, and J. Org. Chem. 57, 3916-3921, 1992]. If computer analysis of tandem mass-spectrometric results predicts this modification, then it is most probable that there are multiple isobaric peptides differing in the location of multiple hydroxylation modifications [JSG].
synonym: "2-hydroxyglycine" EXACT RESID-name []
synonym: "2HyGly" EXACT PSI-MOD-label []
synonym: "alpha-hydroxyglycine" EXACT RESID-alternate []
synonym: "amino(hydroxy)acetic acid" EXACT RESID-systematic []
synonym: "aminohydroxyacetic acid" EXACT RESID-alternate []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 2 H 3 N 1 O 2"
xref: MassAvg: "73.05"
xref: MassMono: "73.016378"
xref: Origin: "G"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:00908 ! modified glycine residue

[Term]
id: MOD:01181
name: L-aspartic acid 4-methyl ester
def: "A protein modification that effectively converts an L-aspartic acid residue to L-aspartate 4-methyl ester." [OMSSA:69, PubMed:1556110, PubMed:16888766, PubMed:9629898, RESID:AA0435, Unimod:34#D]
comment: CAUTION - observations of this modifation are attributable to artifacts produced in preparation. It is extremely unlikely that eukaryotes produce this modification, because an enzyme acting to form the methyl ester of L-aspartyl peptides would interfere with the D-aspartyl peptide repair mechanism [JSG].
synonym: "(2S)-2-amino-4-methoxy-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "2-aminobutanedioic acid 4-methyl ester" EXACT RESID-alternate []
synonym: "4-methyl L-2-aminosuccinic acid" EXACT RESID-alternate []
synonym: "4-methyl L-aspartate" EXACT RESID-alternate []
synonym: "4-methyl L-hydrogen aspartate" EXACT RESID-alternate []
synonym: "aspartic acid 4-methyl ester" EXACT RESID-alternate []
synonym: "aspartic acid beta-methyl ester" EXACT RESID-alternate []
synonym: "L-aspartic acid 4-methyl ester" EXACT RESID-name []
synonym: "meesterd" EXACT OMSSA-label []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "O4MeAsp" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "D"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
is_a: MOD:00393 ! O-methylated residue
is_a: MOD:01681 ! monomethylated L-aspartic acid

[Term]
id: MOD:01182
name: 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD
def: "A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD." [PubMed:, RESID:AA0436]
comment: Cross-link 2.
subset: PSI-MOD-slim
synonym: "6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine" EXACT RESID-systematic []
synonym: "6-(S-cysteinyl)-8alpha-(N(delta1)-histidyl)-FAD" EXACT RESID-alternate []
synonym: "6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FAD" EXACT RESID-alternate []
synonym: "6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FAD" EXACT RESID-alternate []
synonym: "6-(S-cysteinyl)-8alpha-(pros-histidyl)-FAD" EXACT RESID-alternate []
synonym: "6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FAD" EXACT RESID-name []
synonym: "BINDING FAD (covalent; via 2 links)" EXACT UniProt-feature []
synonym: "BINDING FAD (covalent; via 2 links, pros nitrogen)" EXACT UniProt-feature []
synonym: "CROSSLNK 6-(S-cysteinyl)-8alpha-(pros-histidyl)-FAD (His-Cys)" EXACT UniProt-feature []
synonym: "SCys6-NprosHis8a-FAD" EXACT PSI-MOD-label []
xref: DiffAvg: "781.52"
xref: DiffFormula: "C 27 H 29 N 9 O 15 P 2 S 0"
xref: DiffMono: "781.125835"
xref: Formula: "C 36 H 41 N 13 O 17 P 2 S 1"
xref: MassAvg: "1021.81"
xref: MassMono: "1021.193931"
xref: Origin: "C, H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0681
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02048 ! crosslinked L-histidine residue
is_a: MOD:01621 ! flavin crosslinked residues

[Term]
id: MOD:01183
name: L-selenocystine (oxidized selenocysteine) (Sec-Sec)
def: "A protein modification that effectively cross-links two L-selenocysteine residues to form L-selenocystine," [ChEBI:28553, PubMed:17715293, PubMed:6076213, RESID:AA0437]
comment: Cross-link 2; for formation of the same modification by substitution of 2 selenium for 2 sulfur atoms in L-cystine, see MOD:01184.
subset: PSI-MOD-slim
synonym: "(R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic []
synonym: "3,3'-diselenobis(2-aminopropanoic acid)" EXACT RESID-alternate []
synonym: "3,3'-diselenobisalanine" EXACT RESID-alternate []
synonym: "3,3'-diselenodialanine" EXACT RESID-alternate []
synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide" EXACT RESID-alternate []
synonym: "beta,beta'-diselenodialanine" EXACT RESID-alternate []
synonym: "bis(alpha-aminopropionic acid)-beta-diselenide" EXACT RESID-alternate []
synonym: "bis(beta-amino-beta-carboxyethyl)diselenide" EXACT RESID-alternate []
synonym: "CROSSLNK Selenocystine (Sec-Sec)" EXACT UniProt-feature []
synonym: "diselenocysteine" EXACT RESID-alternate []
synonym: "L-selenocystine" EXACT RESID-name []
synonym: "Sec2" EXACT PSI-MOD-label []
synonym: "selenium cystine" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 Se 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 6 H 8 N 2 O 2 Se 2"
xref: MassAvg: "298.08"
xref: MassMono: "299.891620"
xref: Origin: "U, U"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:01158 ! modified L-selenocysteine residue

[Term]
id: MOD:01184
name: L-selenocystine (selenium disubstituted L-cystine)
def: "A protein modification that effectively substitutes two selenium atoms for two sulfur atoms in L-cystine to form L-selenocystine." [PubMed:17715293, RESID:AA0437#CYS2]
comment: Cross-link 2; for formation of the same modification by oxidation of two L-selenocysteine residues, see MOD:01183.
synonym: "(R,R)-3,3'-diselane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic []
synonym: "3,3'-diselenobis(2-aminopropanoic acid)" EXACT RESID-alternate []
synonym: "3,3'-diselenobisalanine" EXACT RESID-alternate []
synonym: "3,3'-diselenodialanine" EXACT RESID-alternate []
synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldiselenide" EXACT RESID-alternate []
synonym: "beta,beta'-diselenodialanine" EXACT RESID-alternate []
synonym: "bis(alpha-aminopropionic acid)-beta-diselenide" EXACT RESID-alternate []
synonym: "bis(beta-amino-beta-carboxyethyl)diselenide" EXACT RESID-alternate []
synonym: "CROSSLNK Selenocystine (Sec-Sec)" EXACT UniProt-feature []
synonym: "diselenocysteine" EXACT RESID-alternate []
synonym: "L-selenocystine" EXACT RESID-name []
synonym: "Se2(S2)Cys2" EXACT PSI-MOD-label []
synonym: "selenium cystine" EXACT RESID-alternate []
xref: DiffAvg: "91.81"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S -2 Se 2"
xref: DiffMono: "93.873250"
xref: Formula: "C 6 H 8 N 2 O 2 Se 2"
xref: MassAvg: "298.08"
xref: MassMono: "299.891620"
xref: Origin: "C, C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01185
name: 4-amidated L-aspartic acid
def: "A protein modification that effectively converts an L-aspartic acid residue to L-asparagine." [PubMed:17962566, RESID:AA0003#ASP]
synonym: "(2S)-2-amino-4-butanediamic acid" EXACT RESID-systematic []
synonym: "2,4-bis(azanyl)-4-oxobutanoic acid" EXACT RESID-alternate []
synonym: "2,4-diamino-4-oxobutanoic acid" EXACT RESID-alternate []
synonym: "2-amino-3-carbamoylpropanoic acid" EXACT RESID-alternate []
synonym: "2-amino-4-butanediamic acid" EXACT RESID-alternate []
synonym: "2-aminosuccinamic acid" EXACT RESID-alternate []
synonym: "2-aminosuccinic acid 4-amide" EXACT RESID-alternate []
synonym: "4NAsp" EXACT PSI-MOD-label []
synonym: "alpha-amino-beta-carbamylpropionic acid" EXACT RESID-alternate []
synonym: "alpha-aminosuccinamic acid" EXACT RESID-alternate []
synonym: "aspartic acid 4-amide" EXACT RESID-alternate []
synonym: "aspartic acid beta-amide" EXACT RESID-alternate []
synonym: "beta-asparagine" EXACT RESID-alternate []
synonym: "L-asparagine" EXACT RESID-name []
synonym: "MOD_RES Amidated aspartic acid" EXACT UniProt-feature []
xref: DiffAvg: "-0.98"
xref: DiffFormula: "C 0 H 1 N 1 O -1"
xref: DiffMono: "-0.984016"
xref: Formula: "C 4 H 6 N 2 O 2"
xref: MassAvg: "114.10"
xref: MassMono: "114.042927"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00674 ! amidated residue
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:01186
name: monoacetylated L-threonine
def: "A protein modification that effectively converts an L-threonine residue to either N-acetyl-L-threonne, or O-acetyl-Lthreonine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "AcThr" EXACT PSI-MOD-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "T"
xref: Source: "natural"
is_a: MOD:00394 ! monoacetylated residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01187
name: L-pyrrolysine residue
def: "A protein modification that inserts or replaces a residue with an L-pyrrolysine residue, a natural pretranslational modification." [ChEBI:21860, PubMed:11435424, PubMed:12029131, PubMed:12029132, PubMed:15314242, PubMed:16096277, RESID:AA0321, Unimod:435]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]aminohexanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-6-[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-ylcarbonyl]azanylhexanoic acid" EXACT RESID-alternate []
synonym: "L-pyrrolysine" EXACT RESID-name []
synonym: "monomethylamine methyltransferase cofactor lysine adduct" EXACT RESID-alternate []
synonym: "N6-(4-methyl-1,2-didehydropyrrolidine-5-carboxyl)-L-lysine" EXACT RESID-alternate []
synonym: "N6-(4-methyl-delta-1-pyrroline-5-carboxyl)-L-lysine" EXACT RESID-alternate []
synonym: "N6-([(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl)-L-lysine" EXACT RESID-alternate []
synonym: "NON_STD Pyrrolysine" EXACT UniProt-feature []
synonym: "Pyl" EXACT PSI-MOD-label []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 12 H 19 N 3 O 2"
xref: MassAvg: "237.30"
xref: MassMono: "237.147727"
xref: Origin: "O"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:435"
is_a: MOD:00868 ! natural, non-standard encoded residue

[Term]
id: MOD:01188
name: N-ethyl iodoacetamide-d5 - site Y
def: "modification from Unimod Isotopic label -" [PubMed:11710128, PubMed:12766232, PubMed:3155470, PubMed:957432, Unimod:212#Y]
synonym: "N-ethyl iodoacetamide-d5" RELATED Unimod-description []
synonym: "NEIAA:2H(5)" RELATED PSI-MS-label []
xref: DiffAvg: "90.08"
xref: DiffFormula: "C 4 (1)H 2 (2)H 5 N 1 O 1"
xref: DiffMono: "90.084148"
xref: Formula: "C 13 (1)H 11 (2)H 5 N 2 O 3"
xref: MassAvg: "253.15"
xref: MassMono: "253.147476"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:212"
is_a: MOD:00562 ! N-ethyl iodoacetamide-d5

[Term]
id: MOD:01189
name: N-ethyl iodoacetamide-d5 - site C
def: "modification from Unimod Isotopic label -" [PubMed:12766232, Unimod:212#C]
synonym: "N-ethyl iodoacetamide-d5" RELATED Unimod-description []
synonym: "NEIAA:2H(5)" RELATED PSI-MS-label []
xref: DiffAvg: "90.08"
xref: DiffFormula: "C 4 (1)H 2 (2)H 5 N 1 O 1"
xref: DiffMono: "90.084148"
xref: Formula: "C 7 (1)H 7 (2)H 5 N 2 O 2 S 1"
xref: MassAvg: "193.09"
xref: MassMono: "193.093332"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:212"
is_a: MOD:00562 ! N-ethyl iodoacetamide-d5

[Term]
id: MOD:01190
name: dibromo
def: "Modification from Unimod Chemical derivative. OBSOLETE because duplicate and redundant with MOD:01006. Remap to MOD:01006." [Unimod:534]
synonym: "Dibromo" RELATED PSI-MS-label []
synonym: "Dibromo" RELATED Unimod-description []
xref: DiffAvg: "157.79"
xref: DiffFormula: "Br 2 H -2"
xref: DiffMono: "155.821024"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "Y"
xref: Source: "none"
xref: TermSpec: "none"
xref: Remap: "MOD:01006"
xref: Unimod: "Unimod:534"
is_obsolete: true

[Term]
id: MOD:01191
name: N-ethyl iodoacetamide-d0 - site C
def: "modification from Unimod Isotopic label -" [PubMed:12766232, Unimod:211#C]
synonym: "N-ethyl iodoacetamide-d0" RELATED Unimod-description []
synonym: "NEIAA" RELATED PSI-MS-label []
xref: DiffAvg: "85.11"
xref: DiffFormula: "C 4 H 7 N 1 O 1"
xref: DiffMono: "85.052764"
xref: Formula: "C 7 H 12 N 2 O 2 S 1"
xref: MassAvg: "188.25"
xref: MassMono: "188.061949"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:211"
is_a: MOD:00561 ! N-ethyl iodoacetamide-d0

[Term]
id: MOD:01192
name: N-ethyl iodoacetamide-d0 - site Y
def: "modification from Unimod Isotopic label -" [PubMed:11760118, PubMed:12766232, Unimod:211#Y]
synonym: "N-ethyl iodoacetamide-d0" RELATED Unimod-description []
synonym: "NEIAA" RELATED PSI-MS-label []
xref: DiffAvg: "85.11"
xref: DiffFormula: "C 4 H 7 N 1 O 1"
xref: DiffMono: "85.052764"
xref: Formula: "C 13 H 16 N 2 O 3"
xref: MassAvg: "248.28"
xref: MassMono: "248.116092"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:211"
is_a: MOD:00561 ! N-ethyl iodoacetamide-d0

[Term]
id: MOD:01193
name: pyridyl thiol modified L-threonine
def: "modification from Unimod Chemical derivative -" [PubMed:1093385, Unimod:264#T]
synonym: "PET" RELATED PSI-MS-label []
synonym: "phosphorylation to pyridyl thiol" RELATED Unimod-description []
xref: DiffAvg: "121.20"
xref: DiffFormula: "C 7 H 7 N 1 O -1 S 1"
xref: DiffMono: "121.035006"
xref: Formula: "C 11 H 14 N 2 O 1 S 1"
xref: MassAvg: "222.31"
xref: MassMono: "222.082684"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:264"
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:00586 ! pyridyl thiol modified residue

[Term]
id: MOD:01194
name: pyridyl thiol modified L-serine
def: "modification from Unimod Chemical derivative -" [PubMed:15279557, Unimod:264#S]
synonym: "PET" RELATED PSI-MS-label []
synonym: "phosphorylation to pyridyl thiol" RELATED Unimod-description []
xref: DiffAvg: "121.20"
xref: DiffFormula: "C 7 H 7 N 1 O -1 S 1"
xref: DiffMono: "121.035006"
xref: Formula: "C 10 H 12 N 2 O 1 S 1"
xref: MassAvg: "208.28"
xref: MassMono: "208.067034"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:264"
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:00586 ! pyridyl thiol modified residue

[Term]
id: MOD:01195
name: benzoyl labeling reagent light form - site K
def: "modification from Unimod Isotopic label -" [PubMed:11813307, PubMed:12777388, PubMed:15456300, Unimod:136#K]
synonym: "Benzoyl" RELATED PSI-MS-label []
synonym: "labeling reagent light form (N-term & K)" RELATED Unimod-description []
xref: DiffAvg: "104.11"
xref: DiffFormula: "C 7 H 4 O 1"
xref: DiffMono: "104.026215"
xref: Formula: "C 13 H 16 N 2 O 2"
xref: MassAvg: "232.28"
xref: MassMono: "232.121178"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:136"
is_a: MOD:00505 ! benzoyl labeling reagent light form (N-term and K)

[Term]
id: MOD:01196
name: 5-dimethylaminonaphthalene-1-sulfonyl - site K
def: "OBSOLETE because redundant, replaced with MOD:01654. Remap to MOD:01654." [Unimod:139]
synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED Unimod-description []
synonym: "Dansyl" RELATED PSI-MS-label []
xref: DiffAvg: "233.29"
xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1"
xref: DiffMono: "233.051050"
xref: Formula: "C 18 H 23 N 3 O 3 S 1"
xref: MassAvg: "361.46"
xref: MassMono: "361.146013"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:01654"
xref: Unimod: "Unimod:139"
is_obsolete: true

[Term]
id: MOD:01197
name: N-heptosyl-L-glutamine
def: "A protein modification that effectively converts an L-glutamine residue to N-heptosyl-L-glutamine." [Unimod:490#Q]
comment: From Unimod with no citation [JSG].
synonym: "Hep" RELATED PSI-MS-label []
synonym: "Heptose" RELATED Unimod-description []
xref: DiffAvg: "192.17"
xref: DiffFormula: "C 7 H 12 O 6"
xref: DiffMono: "192.063388"
xref: Formula: "C 12 H 20 N 2 O 8"
xref: MassAvg: "320.30"
xref: MassMono: "320.121966"
xref: Origin: "Q"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:490"
is_a: MOD:00925 ! heptosylated residue

[Term]
id: MOD:01198
name: O-heptosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-heptosyl-L-serine." [Unimod:490#S]
comment: From Unimod with no citation [JSG].
synonym: "Hep" RELATED PSI-MS-label []
synonym: "Heptose" RELATED Unimod-description []
xref: DiffAvg: "192.17"
xref: DiffFormula: "C 7 H 12 O 6"
xref: DiffMono: "192.063388"
xref: Formula: "C 10 H 17 N 1 O 8"
xref: MassAvg: "279.25"
xref: MassMono: "279.095417"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:490"
is_a: MOD:00925 ! heptosylated residue

[Term]
id: MOD:01199
name: N-heptosyl-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to an N-heptosyl-L-arginine." [Unimod:490#R]
comment: From Unimod with no citation [JSG].
synonym: "Hep" RELATED PSI-MS-label []
synonym: "Heptose" RELATED Unimod-description []
xref: DiffAvg: "192.17"
xref: DiffFormula: "C 7 H 12 O 6"
xref: DiffMono: "192.063388"
xref: Formula: "C 13 H 24 N 4 O 7"
xref: MassAvg: "348.36"
xref: MassMono: "348.164499"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:490"
is_a: MOD:00925 ! heptosylated residue

[Term]
id: MOD:01200
name: O-heptosyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-heptosyl-L-threonine." [Unimod:490#T]
comment: From Unimod with no citation [JSG].
synonym: "Hep" RELATED PSI-MS-label []
synonym: "Heptose" RELATED Unimod-description []
xref: DiffAvg: "192.17"
xref: DiffFormula: "C 7 H 12 O 6"
xref: DiffMono: "192.063388"
xref: Formula: "C 11 H 19 N 1 O 8"
xref: MassAvg: "293.27"
xref: MassMono: "293.111067"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:490"
is_a: MOD:00925 ! heptosylated residue

[Term]
id: MOD:01201
name: N6-heptosyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-heptosyl-L-lysine." [Unimod:490#K]
comment: From Unimod with no citation [JSG].
synonym: "Hep" RELATED PSI-MS-label []
synonym: "Heptose" RELATED Unimod-description []
xref: DiffAvg: "192.17"
xref: DiffFormula: "C 7 H 12 O 6"
xref: DiffMono: "192.063388"
xref: Formula: "C 13 H 24 N 2 O 7"
xref: MassAvg: "320.34"
xref: MassMono: "320.158351"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:490"
is_a: MOD:00925 ! heptosylated residue

[Term]
id: MOD:01202
name: N-heptosyl-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to N-heptosyl-L-asparagine." [Unimod:490#N]
comment: From Unimod with no citation [JSG].
synonym: "Hep" RELATED PSI-MS-label []
synonym: "Heptose" RELATED Unimod-description []
xref: DiffAvg: "192.17"
xref: DiffFormula: "C 7 H 12 O 6"
xref: DiffMono: "192.063388"
xref: Formula: "C 11 H 18 N 2 O 8"
xref: MassAvg: "306.27"
xref: MassMono: "306.106316"
xref: Origin: "N"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:490"
is_a: MOD:00925 ! heptosylated residue

[Term]
id: MOD:01203
name: N6-(pyridylacetyl)lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-[(pyrid-3-yl)acetyl]lysine." [PubMed:9276974, Unimod:25#K]
comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG].
synonym: "Pyridylacetyl" RELATED PSI-MS-label []
synonym: "pyridylacetyl" RELATED Unimod-description []
xref: DiffAvg: "119.12"
xref: DiffFormula: "C 7 H 5 N 1 O 1"
xref: DiffMono: "119.037114"
xref: Formula: "C 13 H 17 N 3 O 2"
xref: MassAvg: "247.30"
xref: MassMono: "247.132077"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:25"
is_a: MOD:00418 ! pyridylacetylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01204
name: prompt loss of methanethiol from oxidixed methionine
def: "modification from Unimod Artifact -" [PubMed:9004526, Unimod:526]
synonym: "Dethiomethyl" RELATED PSI-MS-label []
synonym: "Prompt loss of side chain from oxidised Met" RELATED Unimod-description []
xref: DiffAvg: "-48.10"
xref: DiffFormula: "C -1 H -4 S -1"
xref: DiffMono: "-48.003371"
xref: Formula: "C 4 H 5 N 1 O 1 S 0"
xref: MassAvg: "83.09"
xref: MassMono: "83.037114"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:526"
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:01205
name: Hex1HexNAc1NeuAc2 O-glycosylated serine
def: "A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [PubMed:7949339, Unimod:160#S]
synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc1NeuAc2" RELATED Unimod-description []
xref: DiffAvg: "947.85"
xref: DiffFormula: "C 36 H 57 N 3 O 26"
xref: DiffMono: "947.323029"
xref: Formula: "C 39 H 62 N 4 O 28"
xref: MassAvg: "1034.93"
xref: MassMono: "1034.355057"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:160"
is_a: MOD:00528 ! Hex1HexNAc1NeuAc2 glycosylated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01206
name: Hex1HexNAc1NeuAc2 O-glycosylated threonine
def: "A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [Unimod:160#T]
synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc1NeuAc2" RELATED Unimod-description []
xref: DiffAvg: "947.85"
xref: DiffFormula: "C 36 H 57 N 3 O 26"
xref: DiffMono: "947.323029"
xref: Formula: "C 40 H 64 N 4 O 28"
xref: MassAvg: "1048.95"
xref: MassMono: "1048.370707"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:160"
is_a: MOD:00528 ! Hex1HexNAc1NeuAc2 glycosylated residue
is_a: MOD:00005 ! O-glycosyl-L-threonine

[Term]
id: MOD:01207
name: Hex1HexNAc1NeuAc2 N4-glycosylated asparagine
def: "A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond." [Unimod:160#N]
synonym: "Hex(1)HexNAc(1)NeuAc(2)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc1NeuAc2" RELATED Unimod-description []
xref: DiffAvg: "947.85"
xref: DiffFormula: "C 36 H 57 N 3 O 26"
xref: DiffMono: "947.323029"
xref: Formula: "C 40 H 63 N 5 O 28"
xref: MassAvg: "1061.95"
xref: MassMono: "1061.365956"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:160"
is_a: MOD:00528 ! Hex1HexNAc1NeuAc2 glycosylated residue
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:01208
name: copper(1+) carboxylate C-terminal residue
def: "A protein modification that effectively converts a C-terminal residue to the copper(1+) carboxylate salt." [Unimod:531#C-term]
synonym: "Cation:Cu[I]" RELATED PSI-MS-label []
synonym: "cuprous salt" EXACT PSI-MOD-alternate []
synonym: "Replacement of proton by copper" RELATED Unimod-description []
xref: DiffAvg: "62.54"
xref: DiffFormula: "Cu 1 H -1"
xref: DiffMono: "61.921772"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:531"
is_a: MOD:00742 ! copper containing modified residue

[Term]
id: MOD:01209
name: copper(1+) L-aspartate
def: "A protein modification that effectively converts an L-aspartic acid residue to the copper(1+) aspartate salt." [Unimod:531#D]
synonym: "Cation:Cu[I]" RELATED PSI-MS-label []
synonym: "cuprous salt" EXACT PSI-MOD-alternate []
synonym: "Replacement of proton by copper" RELATED Unimod-description []
xref: DiffAvg: "62.54"
xref: DiffFormula: "Cu 1 H -1"
xref: DiffMono: "61.921772"
xref: Formula: "C 4 Cu 1 H 4 N 1 O 3"
xref: MassAvg: "177.63"
xref: MassMono: "176.948715"
xref: Origin: "D"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:531"
is_a: MOD:00742 ! copper containing modified residue
is_a: MOD:02066 ! metal or metal cluster coordinated L-aspartic acid residue

[Term]
id: MOD:01210
name: copper(1+) L-glutamate
def: "A protein modification that effectively converts an L-glutamic acid residue to the copper(1+) glutamate salt." [Unimod:531#E]
synonym: "Cation:Cu[I]" RELATED PSI-MS-label []
synonym: "cuprous salt" EXACT PSI-MOD-alternate []
synonym: "Replacement of proton by copper" RELATED Unimod-description []
xref: DiffAvg: "62.54"
xref: DiffFormula: "Cu 1 H -1"
xref: DiffMono: "61.921772"
xref: Formula: "C 5 Cu 1 H 6 N 1 O 3"
xref: MassAvg: "191.65"
xref: MassMono: "190.964366"
xref: Origin: "E"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:531"
is_a: MOD:00742 ! copper containing modified residue
is_a: MOD:02068 ! metal or metal cluster coordinated L-glutamic acid residue

[Term]
id: MOD:01211
name: N6-(morpholine-2-acetyl)-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-(morpholine-2-acetyl)-lysine." [PubMed:10446193, Unimod:29#K]
comment: The Unimod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG].
synonym: "N-Succinimidyl-2-morpholine acetate" RELATED Unimod-description []
synonym: "N-succinimidylmorpholine-2-acetate N6-derivatized lysine" EXACT PSI-MOD-alternate []
synonym: "SMA" RELATED PSI-MS-label []
xref: DiffAvg: "127.14"
xref: DiffFormula: "C 6 H 9 N 1 O 2"
xref: DiffMono: "127.063329"
xref: Formula: "C 12 H 21 N 3 O 3"
xref: MassAvg: "255.32"
xref: MassMono: "255.158292"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:29"
is_a: MOD:01813 ! morpholine-2-acetylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01212
name: iodoacetamide N6-derivatized lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-(carboxamidomethyl)lysine." [OMSSA:27, PubMed:11510821, PubMed:12422359, PubMed:12686488, Unimod:4#K]
subset: PSI-MOD-slim
synonym: "Carbamidomethyl" RELATED PSI-MS-label []
synonym: "carbamidomethylk" EXACT OMSSA-label []
synonym: "Iodoacetamide derivative" RELATED Unimod-description []
synonym: "N6-(2-amino-2-oxoethyl)lysine" EXACT PSI-MOD-alternate []
synonym: "N6-(carbamoylmethyl)lysine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "57.05"
xref: DiffFormula: "C 2 H 3 N 1 O 1"
xref: DiffMono: "57.021464"
xref: Formula: "C 8 H 15 N 3 O 2"
xref: MassAvg: "185.23"
xref: MassMono: "185.116427"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:4"
is_a: MOD:00397 ! iodoacetamide derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01213
name: iodoacetamide derivatized histidine
def: "A protein modification that effectively converts an L-histidine residue to an iodoacetamide derivatized histidine, either 1'- or 3'-(carboxamidolmethyl)histidine." [OMSSA:28, PubMed:11510821, PubMed:12422359, PubMed:15627961, PubMed:2026710, Unimod:4#H]
subset: PSI-MOD-slim
synonym: "Carbamidomethyl" RELATED PSI-MS-label []
synonym: "carbamidometylh" EXACT OMSSA-label []
synonym: "Iodoacetamide derivative" RELATED Unimod-description []
xref: DiffAvg: "57.05"
xref: DiffFormula: "C 2 H 3 N 1 O 1"
xref: DiffMono: "57.021464"
xref: Formula: "C 8 H 10 N 4 O 2"
xref: MassAvg: "194.19"
xref: MassMono: "194.080376"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:4"
is_a: MOD:00397 ! iodoacetamide derivatized residue
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:01214
name: iodoacetamide - site C
def: "modification from Unimod Chemical derivative - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060." [PubMed:10504701, PubMed:11510821, PubMed:12422359, Unimod:4#C]
synonym: "Carbamidomethyl" RELATED PSI-MS-label []
synonym: "Iodoacetamide derivative" RELATED Unimod-description []
xref: DiffAvg: "57.05"
xref: DiffFormula: "C 2 H 3 N 1 O 1"
xref: DiffMono: "57.021464"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:01060"
xref: Unimod: "Unimod:4"
is_obsolete: true

[Term]
id: MOD:01215
name: iodoacetamide derivatized aspartic acid
def: "A protein modification that effectively converts an L-aspartic acid residue to O4-(carboxamidomethyl)aspartate." [OMSSA:29, PubMed:11510821, PubMed:12422359, PubMed:16526082, Unimod:4#D]
subset: PSI-MOD-slim
synonym: "Carbamidomethyl" RELATED PSI-MS-label []
synonym: "carbamidomethyld" EXACT OMSSA-label []
synonym: "Iodoacetamide derivative" RELATED Unimod-description []
xref: DiffAvg: "57.05"
xref: DiffFormula: "C 2 H 3 N 1 O 1"
xref: DiffMono: "57.021464"
xref: Formula: "C 6 H 8 N 2 O 4"
xref: MassAvg: "172.14"
xref: MassMono: "172.048407"
xref: Origin: "D"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:4"
is_a: MOD:00397 ! iodoacetamide derivatized residue
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:01216
name: iodoacetamide derivatized glutamic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to O5-(carboxamidomethyl)glutamate." [OMSSA:30, PubMed:11510821, PubMed:12422359, Unimod:4#E]
subset: PSI-MOD-slim
synonym: "Carbamidomethyl" RELATED PSI-MS-label []
synonym: "carbamidomethyle" EXACT OMSSA-label []
synonym: "Iodoacetamide derivative" RELATED Unimod-description []
xref: DiffAvg: "57.05"
xref: DiffFormula: "C 2 H 3 N 1 O 1"
xref: DiffMono: "57.021464"
xref: Formula: "C 7 H 10 N 2 O 4"
xref: MassAvg: "186.17"
xref: MassMono: "186.064057"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:4"
is_a: MOD:00397 ! iodoacetamide derivatized residue
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:01217
name: Sulfanilic Acid (SA), light C12 - site D
def: "modification from Unimod Isotopic label -" [PubMed:12872131, Unimod:285#D]
synonym: "Light Sulfanilic Acid (SA) C12" RELATED Unimod-description []
synonym: "SulfanilicAcid" RELATED PSI-MS-label []
xref: DiffAvg: "155.00"
xref: DiffFormula: "(12)C 6 H 5 N 1 O 2 S 1"
xref: DiffMono: "155.004099"
xref: Formula: "(12)C 10 H 10 N 2 O 5 S 1"
xref: MassAvg: "270.03"
xref: MassMono: "270.031042"
xref: Origin: "D"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:285"
is_a: MOD:00605 ! Sulfanilic Acid (SA), light C12

[Term]
id: MOD:01218
name: Sulfanilic Acid (SA), light C12 - site E
def: "modification from Unimod Isotopic label -" [PubMed:15283597, Unimod:285#E]
synonym: "Light Sulfanilic Acid (SA) C12" RELATED Unimod-description []
synonym: "SulfanilicAcid" RELATED PSI-MS-label []
xref: DiffAvg: "155.00"
xref: DiffFormula: "(12)C 6 H 5 N 1 O 2 S 1"
xref: DiffMono: "155.004099"
xref: Formula: "(12)C 11 H 12 N 2 O 5 S 1"
xref: MassAvg: "284.05"
xref: MassMono: "284.046692"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:285"
is_a: MOD:00605 ! Sulfanilic Acid (SA), light C12

[Term]
id: MOD:01219
name: Sulfanilic Acid (SA), heavy C13 - site D
def: "modification from Unimod Chemical derivative -" [PubMed:9254591, PubMed:9750125, Unimod:286#D]
synonym: "Heavy Sulfanilic Acid (SA) C13" RELATED Unimod-description []
synonym: "SulfanilicAcid:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "161.02"
xref: DiffFormula: "(13)C 6 H 5 N 1 O 2 S 1"
xref: DiffMono: "161.024228"
xref: Formula: "(12)C 4 (13)C 6 H 10 N 2 O 5 S 1"
xref: MassAvg: "276.05"
xref: MassMono: "276.051171"
xref: Origin: "D"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:286"
is_a: MOD:00606 ! Sulfanilic Acid (SA), heavy C13

[Term]
id: MOD:01220
name: Sulfanilic Acid (SA), heavy C13 - site E
def: "modification from Unimod Chemical derivative -" [PubMed:15121203, PubMed:9254591, Unimod:286#E]
synonym: "Heavy Sulfanilic Acid (SA) C13" RELATED Unimod-description []
synonym: "SulfanilicAcid:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "161.02"
xref: DiffFormula: "(13)C 6 H 5 N 1 O 2 S 1"
xref: DiffMono: "161.024228"
xref: Formula: "(12)C 5 (13)C 6 H 12 N 2 O 5 S 1"
xref: MassAvg: "290.07"
xref: MassMono: "290.066822"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:286"
is_a: MOD:00606 ! Sulfanilic Acid (SA), heavy C13

[Term]
id: MOD:01221
name: O-formyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-formyl-L-threonine." [PubMed:11861642, PubMed:15799070, Unimod:122#T]
comment: From Unimod: Can occur under CNBr cleavage conditions (70% HCOOH).
synonym: "Formyl" RELATED PSI-MS-label []
synonym: "Formylation" RELATED Unimod-description []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:122"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01483 ! O-formylated residue

[Term]
id: MOD:01222
name: O-formyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-formyl-L-serine." [PubMed:15627961, PubMed:15799070, Unimod:122#S]
comment: From Unimod: Can occur under CNBr cleavage conditions (70% HCOOH).
synonym: "Formyl" RELATED PSI-MS-label []
synonym: "Formylation" RELATED Unimod-description []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "C 4 H 5 N 1 O 3"
xref: MassAvg: "115.09"
xref: MassMono: "115.026943"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:122"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01483 ! O-formylated residue

[Term]
id: MOD:01223
name: thioacylation of primary amines - site N-term
def: "modification from Unimod Other -" [OMSSA:41, PubMed:11710128, PubMed:3155470, PubMed:957432, Unimod:126#N-term]
comment: This Unimod entry is misdescribed as "thioacylation" [JSG].
synonym: "3,3-Dithio-bis-(sulfosuccinimidyl)propionate" RELATED Unimod-alternate []
synonym: "ntermpeptioacetyl" EXACT OMSSA-label []
synonym: "Thioacyl" RELATED PSI-MS-label []
synonym: "thioacylation of primary amines (N-term and Lys)" RELATED Unimod-description []
xref: DiffAvg: "88.12"
xref: DiffFormula: "C 3 H 4 O 1 S 1"
xref: DiffMono: "87.998286"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:126"
is_a: MOD:00497 ! 3-sulfanylpropanoyl (N-term and Lys)

[Term]
id: MOD:01224
name: thioacylation of primary amines - site K
def: "modification from Unimod Other -" [OMSSA:40, PubMed:11710128, PubMed:3155470, PubMed:957432, Unimod:126#K]
comment: This Unimod entry is misdescribed as "thioacylation" [JSG].
synonym: "3,3-Dithio-bis-(sulfosuccinimidyl)propionate" RELATED Unimod-alternate []
synonym: "thioacetylk" EXACT OMSSA-label []
synonym: "Thioacyl" RELATED PSI-MS-label []
synonym: "thioacylation of primary amines (N-term and Lys)" RELATED Unimod-description []
xref: DiffAvg: "88.12"
xref: DiffFormula: "C 3 H 4 O 1 S 1"
xref: DiffMono: "87.998286"
xref: Formula: "C 9 H 16 N 2 O 2 S 1"
xref: MassAvg: "216.30"
xref: MassMono: "216.093249"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:126"
is_a: MOD:00497 ! 3-sulfanylpropanoyl (N-term and Lys)

[Term]
id: MOD:01225
name: monofluorinated L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue into an L-fluorotyrosine." [OMSSA:46, PubMed:8069568, Unimod:127#Y]
comment: From Unimod: the citation appears to be correct, but the PMID is not and has been corrected [JSG].
synonym: "Fluoro" RELATED PSI-MS-label []
synonym: "fluorophenylalanine replacement of phenylalanine" RELATED Unimod-description []
synonym: "phef" EXACT OMSSA-label []
xref: DiffAvg: "17.99"
xref: DiffFormula: "F 1 H -1"
xref: DiffMono: "17.990578"
xref: Formula: "C 9 F 1 H 8 N 1 O 2"
xref: MassAvg: "181.17"
xref: MassMono: "181.053907"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:127"
is_a: MOD:00498 ! fluorinated residue
is_a: MOD:00985 ! halogenated tyrosine

[Term]
id: MOD:01226
name: monofluorinated L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to an L-fluorotryptophan." [PubMed:8069568, Unimod:127#W]
comment: From Unimod: the citation appears to be correct, but the PMID is not and has been corrected [JSG].
synonym: "Fluoro" RELATED PSI-MS-label []
synonym: "fluorophenylalanine replacement of phenylalanine" RELATED Unimod-description []
xref: DiffAvg: "17.99"
xref: DiffFormula: "F 1 H -1"
xref: DiffMono: "17.990578"
xref: Formula: "C 11 F 1 H 9 N 2 O 1"
xref: MassAvg: "204.20"
xref: MassMono: "204.069891"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:127"
is_a: MOD:00498 ! fluorinated residue
is_a: MOD:01068 ! halogenated tryptophan

[Term]
id: MOD:01227
name: monofluorinated L-phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to an L-fluorophenylalanine." [DeltaMass:181, OMSSA:46, PubMed:8069568, Unimod:127#F]
comment: From Unimod: the citation appears to be correct, but the PMID is not and has been corrected. From DeltaMass: (element abbreviation in formula incorrect, mass incorrect, and aggregate not delta) Average Mass: 149 Formula: C9H8O1N1Fl1 Average Mass Change: 149 References:PE Sciex with no citation [JSG].
synonym: "Fluoro" RELATED PSI-MS-label []
synonym: "fluorophenylalanine replacement of phenylalanine" RELATED Unimod-description []
synonym: "phef" EXACT OMSSA-label []
xref: DiffAvg: "17.99"
xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0"
xref: DiffMono: "17.990578"
xref: Formula: "C 9 F 1 H 8 N 1 O 1"
xref: MassAvg: "165.17"
xref: MassMono: "165.058992"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:127"
is_a: MOD:00498 ! fluorinated residue
is_a: MOD:01066 ! halogenated phenylalanine

[Term]
id: MOD:01228
name: monoiodinated tyrosine
def: "A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one iodine atom." [DeltaMass:0, OMSSA:65, PubMed:1326520, PubMed:15627961, PubMed:2026710, Unimod:129#Y]
comment: From DeltaMass: Average Mass: 289 [name misspelled "monoiodated" - JSG].
subset: PSI-MOD-slim
synonym: "I1Tyr" EXACT PSI-MOD-label []
synonym: "Iodination" RELATED Unimod-description []
synonym: "iodinationy" EXACT OMSSA-label []
synonym: "Iodo" RELATED PSI-MS-label []
xref: DiffAvg: "125.90"
xref: DiffFormula: "H -1 I 1"
xref: DiffMono: "125.896648"
xref: Formula: "C 9 H 8 I 1 N 1 O 2"
xref: MassAvg: "289.07"
xref: MassMono: "288.959976"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:129"
is_a: MOD:00500 ! monoiodinated residue
is_a: MOD:00998 ! iodinated tyrosine

[Term]
id: MOD:01229
name: L-iodohistidine
def: "A protein modification that effectively converts an L-histidine residue to an L-iodohistidine." [PubMed:15627961, PubMed:2026710, Unimod:129#H]
synonym: "I1His" EXACT PSI-MOD-label []
synonym: "Iodination" RELATED Unimod-description []
synonym: "Iodo" RELATED PSI-MS-label []
xref: DiffAvg: "125.90"
xref: DiffFormula: "C 0 H -1 I 1 N 0 O 0"
xref: DiffMono: "125.896648"
xref: Formula: "C 6 H 6 I 1 N 3 O 1"
xref: MassAvg: "263.04"
xref: MassMono: "262.955560"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:129"
is_a: MOD:00500 ! monoiodinated residue
is_a: MOD:01049 ! halogenated histidine

[Term]
id: MOD:01230
name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form - site K
def: "modification from Unimod Isotopic label -" [PubMed:15602776, Unimod:365#K]
synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form" RELATED Unimod-description []
synonym: "ICPL" RELATED PSI-MS-label []
xref: DiffAvg: "105.02"
xref: DiffFormula: "(12)C 6 H 3 N 1 O 1"
xref: DiffMono: "105.021464"
xref: Formula: "(12)C 12 H 15 N 3 O 2"
xref: MassAvg: "233.12"
xref: MassMono: "233.116427"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:365"
is_a: MOD:00790 ! Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, light form

[Term]
id: MOD:01231
name: 3x(13)C labeled N6-propanoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 3x(13)C labeled N6-propanoyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:12442261, Unimod:59#K]
subset: PSI-MOD-slim
synonym: "Propionate labeling reagent heavy form (+3amu), N-term & K" RELATED Unimod-description []
synonym: "Propionyl:13C(3)" RELATED PSI-MS-label []
xref: DiffAvg: "59.04"
xref: DiffFormula: "(13)C 3 H 4 O 1"
xref: DiffMono: "59.036279"
xref: Formula: "(12)C 6 (13)C 3 H 16 N 2 O 2"
xref: MassAvg: "187.13"
xref: MassMono: "187.131242"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:59"
relationship: derives_from MOD:01398 ! N6-propanoyl-L-lysine
is_a: MOD:01428 ! (13)C isotope tagged reagent

[Term]
id: MOD:01232
name: 3x(12)C labeled N6-propanoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 3x(12)C labeled N6-propanoyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, Unimod:58#K]
subset: PSI-MOD-slim
synonym: "Propionate labeling reagent light form (N-term & K)" RELATED Unimod-description []
synonym: "Propionyl" RELATED PSI-MS-label []
xref: DiffAvg: "56.03"
xref: DiffFormula: "(12)C 3 H 4 O 1"
xref: DiffMono: "56.026215"
xref: Formula: "(12)C 9 H 16 N 2 O 2"
xref: MassAvg: "184.12"
xref: MassMono: "184.121178"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:58"
relationship: derives_from MOD:01398 ! N6-propanoyl-L-lysine
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:01233
name: 3x(2)H labeled N6-acetyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled N6-acetyl-L-lysine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, Unimod:56#K]
subset: PSI-MOD-slim
synonym: "Acetate labeling reagent (N-term & K) (heavy form, +3amu)" RELATED Unimod-description []
synonym: "Acetyl:2H(3)" RELATED PSI-MS-label []
xref: DiffAvg: "45.03"
xref: DiffFormula: "C 2 (1)H -1 (2)H 3 O 1"
xref: DiffMono: "45.029395"
xref: Formula: "C 8 (1)H 11 (2)H 3 N 2 O 2"
xref: MassAvg: "173.12"
xref: MassMono: "173.124358"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:56"
relationship: derives_from MOD:00064 ! N6-acetyl-L-lysine
is_a: MOD:00449 ! acetate labeling reagent (N-term) (heavy form, +3amu)

[Term]
id: MOD:01234
name: (18)O monosubstituted L-serine
def: "modification from Unimod Isotopic label - alkaline phosphatase to dephosphorylate" [PubMed:11467524, Unimod:258#S]
subset: PSI-MOD-slim
synonym: "Label:18O(1)" RELATED PSI-MS-label []
synonym: "O18 Labeling" RELATED Unimod-description []
xref: DiffAvg: "2.00"
xref: DiffFormula: "(16)O -1 (18)O 1"
xref: DiffMono: "2.004246"
xref: Formula: "C 3 H 5 N 1 (16)O 1 (18)O 1"
xref: MassAvg: "89.04"
xref: MassMono: "89.036275"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:258"
is_a: MOD:00581 ! (18)O monosubstituted residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01235
name: (18)O monosubstituted L-threonine
def: "modification from Unimod Isotopic label - alkaline phosphatase to dephosphorylate" [PubMed:11467524, PubMed:15549660, Unimod:258#T]
subset: PSI-MOD-slim
synonym: "Label:18O(1)" RELATED PSI-MS-label []
synonym: "O18 Labeling" RELATED Unimod-description []
xref: DiffAvg: "2.00"
xref: DiffFormula: "(16)O -1 (18)O 1"
xref: DiffMono: "2.004246"
xref: Formula: "C 4 H 7 N 1 (16)O 1 (18)O 1"
xref: MassAvg: "103.05"
xref: MassMono: "103.051925"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:258"
is_a: MOD:00581 ! (18)O monosubstituted residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01236
name: (18)O monosubstituted L-tyrosine
def: "modification from Unimod Isotopic label - alkaline phosphatase to dephosphorylate" [PubMed:11467524, PubMed:15549660, Unimod:258#Y]
subset: PSI-MOD-slim
synonym: "Label:18O(1)" RELATED PSI-MS-label []
synonym: "O18 Labeling" RELATED Unimod-description []
xref: DiffAvg: "2.00"
xref: DiffFormula: "(16)O -1 (18)O 1"
xref: DiffMono: "2.004246"
xref: Formula: "C 9 H 9 N 1 (16)O 1 (18)O 1"
xref: MassAvg: "165.07"
xref: MassMono: "165.067575"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:258"
is_a: MOD:00581 ! (18)O monosubstituted residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:01237
name: cysteine 4-hydroxynonenal adduct
def: "A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal." [PubMed:11327326, PubMed:15133838, PubMed:9629898, Unimod:53#C]
comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG].
synonym: "4-hydroxynonenal (HNE)" RELATED Unimod-description []
synonym: "HNE" RELATED PSI-MS-label []
xref: DiffAvg: "156.22"
xref: DiffFormula: "C 9 H 16 O 2"
xref: DiffMono: "156.115030"
xref: Formula: "C 12 H 21 N 1 O 3 S 1"
xref: MassAvg: "259.36"
xref: MassMono: "259.124215"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:53"
is_a: MOD:00446 ! 4-hydroxynonenal adduct

[Term]
id: MOD:01238
name: lysine 4-hydroxynonenal adduct
def: "A protein modification produced by formation of an adduct of an L-lysine residue with 4-hydroxynonenal." [PubMed:11327326, PubMed:15133838, PubMed:9629898, Unimod:53#K]
comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG].
synonym: "4-hydroxynonenal (HNE)" RELATED Unimod-description []
synonym: "HNE" RELATED PSI-MS-label []
xref: DiffAvg: "156.22"
xref: DiffFormula: "C 9 H 16 O 2"
xref: DiffMono: "156.115030"
xref: Formula: "C 15 H 28 N 2 O 3"
xref: MassAvg: "284.40"
xref: MassMono: "284.209993"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:53"
is_a: MOD:00446 ! 4-hydroxynonenal adduct

[Term]
id: MOD:01239
name: histidine 4-hydroxynonenal adduct
def: "A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal." [PubMed:10717661, PubMed:11327326, PubMed:15133838, Unimod:53#H]
comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG].
synonym: "4-hydroxynonenal (HNE)" RELATED Unimod-description []
synonym: "HNE" RELATED PSI-MS-label []
xref: DiffAvg: "156.22"
xref: DiffFormula: "C 9 H 16 O 2"
xref: DiffMono: "156.115030"
xref: Formula: "C 15 H 23 N 3 O 3"
xref: MassAvg: "293.37"
xref: MassMono: "293.173942"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:53"
is_a: MOD:00446 ! 4-hydroxynonenal adduct

[Term]
id: MOD:01240
name: ubiquitination signature tetrapeptidyl lysine
def: "A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of leucyl-arginyl-glycyl-glycine, the C-terminal tetrapeptide of ubiquitin." [PubMed:10504701, Unimod:535]
synonym: "LeuArgGlyGly" RELATED PSI-MS-label []
synonym: "Ubiquitination" RELATED Unimod-description []
xref: DiffAvg: "383.45"
xref: DiffFormula: "C 16 H 29 N 7 O 4"
xref: DiffMono: "383.228102"
xref: Formula: "C 22 H 41 N 9 O 5"
xref: MassAvg: "511.63"
xref: MassMono: "511.323065"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:535"
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01875 ! N6-acylated L-lysine
relationship: derives_from MOD:01148 ! ubiquitinylated lysine

[Term]
id: MOD:01241
name: 3x(2)H labeled L-aspartic acid 4-methyl ester
def: "A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-aspartic acid 4-methyl ester." [OMSSA:19, PubMed:12185208, Unimod:298#D]
synonym: "deuterated methyl ester" RELATED Unimod-description []
synonym: "Methyl:2H(3)" RELATED PSI-MS-label []
synonym: "trideuteromethyld" EXACT OMSSA-label []
xref: DiffAvg: "17.03"
xref: DiffFormula: "C 1 (1)H -1 (2)H 3"
xref: DiffMono: "17.034480"
xref: Formula: "C 5 (1)H 4 (2)H 3 N 1 O 3"
xref: MassAvg: "132.06"
xref: MassMono: "132.061423"
xref: Origin: "D"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:298"
is_a: MOD:00617 ! 3x(2)H residue methyl ester
is_a: MOD:00904 ! modified L-aspartic acid residue
relationship: derives_from MOD:01181 ! L-aspartic acid 4-methyl ester

[Term]
id: MOD:01242
name: 3x(2)H labeled L-glutamic acid 5-methyl ester
def: "A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-glutamic acid 5-methyl ester." [OMSSA:20, PubMed:1326520, Unimod:298#E]
synonym: "deuterated methyl ester" RELATED Unimod-description []
synonym: "Methyl:2H(3)" RELATED PSI-MS-label []
synonym: "trideuteromethyle" EXACT OMSSA-label []
xref: DiffAvg: "17.03"
xref: DiffFormula: "C 1 (1)H -1 (2)H 3"
xref: DiffMono: "17.034480"
xref: Formula: "C 6 (1)H 6 (2)H 3 N 1 O 3"
xref: MassAvg: "146.08"
xref: MassMono: "146.077073"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:298"
is_a: MOD:00617 ! 3x(2)H residue methyl ester
is_a: MOD:00906 ! modified L-glutamic acid residue
relationship: derives_from MOD:00081 ! L-glutamic acid 5-methyl ester (Glu)

[Term]
id: MOD:01243
name: potassium carboxylate C-terminal residue
def: "A protein modification that effectively converts a C-terminal residue to the potassium carboxylate salt." [Unimod:530#C-term]
synonym: "Cation:K" RELATED PSI-MS-label []
synonym: "Replacement of proton by potassium" RELATED Unimod-description []
xref: DiffAvg: "38.09"
xref: DiffFormula: "H -1 K 1"
xref: DiffMono: "37.955882"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:530"
is_a: MOD:01072 ! monopotassium salt

[Term]
id: MOD:01244
name: potassium L-glutamate
def: "A protein modification that effectively converts an L-glutamioc acid residue to the potassium glutamate salt." [Unimod:530#E]
synonym: "Cation:K" RELATED PSI-MS-label []
synonym: "Replacement of proton by potassium" RELATED Unimod-description []
xref: DiffAvg: "38.09"
xref: DiffFormula: "H -1 K 1"
xref: DiffMono: "37.955882"
xref: Formula: "C 5 H 6 K 1 N 1 O 3"
xref: MassAvg: "167.21"
xref: MassMono: "166.998475"
xref: Origin: "E"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:530"
is_a: MOD:00906 ! modified L-glutamic acid residue
is_a: MOD:01072 ! monopotassium salt

[Term]
id: MOD:01245
name: potassium L-aspartate
def: "A protein modification that effectively converts an L-aspartic acid residue to the potassium aspartate salt." [Unimod:530#D]
synonym: "Cation:K" RELATED PSI-MS-label []
synonym: "Replacement of proton by potassium" RELATED Unimod-description []
xref: DiffAvg: "38.09"
xref: DiffFormula: "H -1 K 1"
xref: DiffMono: "37.955882"
xref: Formula: "C 4 H 4 K 1 N 1 O 3"
xref: MassAvg: "153.18"
xref: MassMono: "152.982825"
xref: Origin: "D"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:530"
is_a: MOD:00904 ! modified L-aspartic acid residue
is_a: MOD:01072 ! monopotassium salt

[Term]
id: MOD:01246
name: fucosylated -site S
def: "OBSOLETE because redundant and identical to MOD:00812 after formula correction. Remap to MOD:00812." [PubMed:11344537, PubMed:15189151, PubMed:3311742, PubMed:3578767, Unimod:295#S]
synonym: "dHex" RELATED PSI-MS-label []
synonym: "Fucose" RELATED Unimod-description []
xref: DiffAvg: "147.15"
xref: DiffFormula: "C 6 H 11 O 4"
xref: DiffMono: "147.065734"
xref: Formula: "C 9 H 16 N 1 O 6"
xref: MassAvg: "234.23"
xref: MassMono: "234.097762"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:00812"
xref: Unimod: "Unimod:295"
is_obsolete: true

[Term]
id: MOD:01247
name: fucosylated -site T
def: "OBSOLETE because redundant and identical to MOD:00813 after formula correction. Remap to MOD:00813." [PubMed:11344537, PubMed:11857757, PubMed:15189151, Unimod:295#T]
synonym: "dHex" RELATED PSI-MS-label []
synonym: "Fucose" RELATED Unimod-description []
xref: DiffAvg: "147.15"
xref: DiffFormula: "C 6 H 11 O 4"
xref: DiffMono: "147.065734"
xref: Formula: "C 10 H 18 N 1 O 6"
xref: MassAvg: "248.26"
xref: MassMono: "248.113412"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:00813"
xref: Unimod: "Unimod:295"
is_obsolete: true

[Term]
id: MOD:01248
name: iodouridine monophosphate derivatized tyrosine
def: "A protein modification that is produced by reaction of iodouridine monophosphate with an L-tyrosine residue to form an ether linkage." [PubMed:11112526, PubMed:11567090, PubMed:6540775, Unimod:292#Y]
comment: This has an ether linkage and not a phosphodiester linkage with UMP.
synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED Unimod-description []
synonym: "IodoU-AMP" RELATED PSI-MS-label []
xref: DiffAvg: "322.17"
xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1"
xref: DiffMono: "322.020217"
xref: Formula: "C 18 H 20 N 3 O 11 P 1"
xref: MassAvg: "485.34"
xref: MassMono: "485.083545"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:292"
is_a: MOD:00611 ! iodouridine monophosphate derivatized residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:01249
name: iodouridine monophosphate derivatized tryptophan
def: "A protein modification that is produced by reaction of iodouridine monophosphate with an L-tryptophan residue." [PubMed:11112526, PubMed:11567090, PubMed:6540775, Unimod:292#W]
comment: This has a carbon-nitrogen linkage and not a phosphodiester linkage with UMP.
synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED Unimod-description []
synonym: "IodoU-AMP" RELATED PSI-MS-label []
xref: DiffAvg: "322.17"
xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1"
xref: DiffMono: "322.020217"
xref: Formula: "C 20 H 21 N 4 O 10 P 1"
xref: MassAvg: "508.38"
xref: MassMono: "508.099530"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:292"
is_a: MOD:00611 ! iodouridine monophosphate derivatized residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:01250
name: iodouridine monophosphate derivatized phenylalanine
def: "A protein modification that is produced by reaction of iodouridine monophosphate with an L-phenylalanine residue." [PubMed:11112526, PubMed:11567090, PubMed:6540775, Unimod:292#F]
comment: This has a carbon-carbon linkage and not a phosphodiester linkage with UMP.
synonym: "Cross-link of (Iodo)-uracil MP with W,F,Y" RELATED Unimod-description []
synonym: "IodoU-AMP" RELATED PSI-MS-label []
xref: DiffAvg: "322.17"
xref: DiffFormula: "C 9 H 11 N 2 O 9 P 1"
xref: DiffMono: "322.020217"
xref: Formula: "C 18 H 20 N 3 O 10 P 1"
xref: MassAvg: "469.34"
xref: MassMono: "469.088630"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:292"
is_a: MOD:00611 ! iodouridine monophosphate derivatized residue
is_a: MOD:00914 ! modified L-phenylalanine residue

[Term]
id: MOD:01251
name: N6-[3-(carboxamidomethylthio)propanoyl]lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-[3-(carboxamidomethylthio)propanoyl]lysine." [PubMed:15121203, Unimod:293#K]
synonym: "3-(carbamidomethylthio)propanoyl" RELATED Unimod-description []
synonym: "CAMthiopropanoyl" RELATED PSI-MS-label []
xref: DiffAvg: "145.18"
xref: DiffFormula: "C 5 H 7 N 1 O 2 S 1"
xref: DiffMono: "145.019749"
xref: Formula: "C 11 H 19 N 3 O 3 S 1"
xref: MassAvg: "273.35"
xref: MassMono: "273.114712"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:293"
is_a: MOD:00612 ! 3-(carboxamidomethylthio)propanoylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01252
name: 5-hydro-5-methylimidazol-4-one, methylglyoxal arginine adduct (+54 amu)
def: "OBSOLETE because redundant and identical to MOD:00933. Remap to MOD:00933." [PubMed:9448752, Unimod:319#R]
synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label []
synonym: "MDA adduct +54" RELATED Unimod-description []
xref: DiffAvg: "54.05"
xref: DiffFormula: "C 3 H 2 O 1"
xref: DiffMono: "54.010565"
xref: Formula: "C 9 H 14 N 4 O 2"
xref: MassAvg: "210.24"
xref: MassMono: "210.111676"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00933"
xref: Unimod: "Unimod:319"
is_obsolete: true

[Term]
id: MOD:01253
name: malondialdehyde lysine adduct (+54 amu)
def: "modification from Unimod Chemical derivative - Malondialdehyde (MDA) adduct" [Unimod:319#K]
synonym: "Delta:H(2)C(3)O(1)" RELATED PSI-MS-label []
synonym: "MDA adduct +54" RELATED Unimod-description []
xref: DiffAvg: "54.05"
xref: DiffFormula: "C 3 H 2 O 1"
xref: DiffMono: "54.010565"
xref: Formula: "C 9 H 14 N 2 O 2"
xref: MassAvg: "182.22"
xref: MassMono: "182.105528"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:319"
is_a: MOD:00630 ! C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine.
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01254
name: 4x(2)H labeled dimethylated L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 4x(2)H labeled dimethylated L-lysine." [OMSSA:189, PubMed:14670044, Unimod:199#K]
subset: PSI-MOD-slim
synonym: "DiMethyl-CHD2" RELATED Unimod-description []
synonym: "Dimethyl:2H(4)" RELATED PSI-MS-label []
synonym: "mod189" EXACT OMSSA-label []
xref: DiffAvg: "32.06"
xref: DiffFormula: "C 2 (2)H 4"
xref: DiffMono: "32.056407"
xref: Formula: "C 8 H 12 (2)H 4 N 2 O 1"
xref: MassAvg: "160.15"
xref: MassMono: "160.151370"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:199"
is_a: MOD:00552 ! 4x(2)H labeled dimethylated residue
is_a: MOD:00912 ! modified L-lysine residue
relationship: derives_from MOD:00084 ! N6,N6-dimethyl-L-lysine

[Term]
id: MOD:01255
name: S-(2-sulfanylethyl)cysteine (Ser)
def: "A protein modification that effectively converts an L-serine residue to S-(2-sulfanylethyl)cysteine." [PubMed:11507762, Unimod:200#S]
synonym: "EDT" RELATED Unimod-description []
synonym: "Ethanedithiol" RELATED PSI-MS-label []
synonym: "S-(2-mercaptoethyl)cysteine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "76.18"
xref: DiffFormula: "C 2 H 4 O -1 S 2"
xref: DiffMono: "75.980528"
xref: Formula: "C 5 H 9 N 1 O 1 S 2"
xref: MassAvg: "163.25"
xref: MassMono: "163.012556"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:200"
is_a: MOD:00553 ! 1,2-ethanedithiol modified residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01256
name: 3-methyl-S-(2-sulfanylethyl)cysteine (Thr)
def: "A protein modification that effectively converts an L-threonine residue to 3-methyl-S-(2-sulfanylethyl)cysteine." [PubMed:11507762, Unimod:200#T]
synonym: "beta-methyl-S-(2-mercaptoethyl)cysteine" EXACT PSI-MOD-alternate []
synonym: "EDT" RELATED Unimod-description []
synonym: "Ethanedithiol" RELATED PSI-MS-label []
xref: DiffAvg: "76.18"
xref: DiffFormula: "C 2 H 4 O -1 S 2"
xref: DiffMono: "75.980528"
xref: Formula: "C 6 H 11 N 1 O 1 S 2"
xref: MassAvg: "177.28"
xref: MassMono: "177.028206"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:200"
is_a: MOD:00553 ! 1,2-ethanedithiol modified residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01257
name: 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate - site K
def: "modification from Unimod Chemical derivative -" [PubMed:12716131, PubMed:14997490, Unimod:194#K]
synonym: "6-aminoquinolyl-N-hydroxysuccinimidyl carbamate" RELATED Unimod-description []
synonym: "AccQTag" RELATED PSI-MS-label []
xref: DiffAvg: "170.17"
xref: DiffFormula: "C 10 H 6 N 2 O 1"
xref: DiffMono: "170.048013"
xref: Formula: "C 16 H 18 N 4 O 2"
xref: MassAvg: "298.35"
xref: MassMono: "298.142976"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:194"
is_a: MOD:00547 ! 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate

[Term]
id: MOD:01258
name: N-methylmaleimide modified L-cysteine
def: "modification from Unimod Chemical derivative -" [PubMed:9448752, Unimod:314#C]
synonym: "Nmethylmaleimide" RELATED PSI-MS-label []
synonym: "Nmethylmaleimide" RELATED Unimod-description []
xref: DiffAvg: "111.10"
xref: DiffFormula: "C 5 H 5 N 1 O 2"
xref: DiffMono: "111.032028"
xref: Formula: "C 8 H 10 N 2 O 3 S 1"
xref: MassAvg: "214.24"
xref: MassMono: "214.041213"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:314"
is_a: MOD:00625 ! N-methylmaleimide derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01259
name: N-methylmaleimide modified L-lysine
def: "modification from Unimod Chemical derivative -" [PubMed:9448752, Unimod:314#K]
synonym: "Nmethylmaleimide" RELATED PSI-MS-label []
synonym: "Nmethylmaleimide" RELATED Unimod-description []
xref: DiffAvg: "111.10"
xref: DiffFormula: "C 5 H 5 N 1 O 2"
xref: DiffMono: "111.032028"
xref: Formula: "C 11 H 17 N 3 O 3"
xref: MassAvg: "239.27"
xref: MassMono: "239.126991"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:314"
is_a: MOD:00625 ! N-methylmaleimide derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01260
name: nucleophilic addtion to cytopiloyne - site Y
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:15549660, Unimod:270#Y]
synonym: "Cytopiloyne" RELATED PSI-MS-label []
synonym: "nucleophilic addtion to cytopiloyne" RELATED Unimod-description []
xref: DiffAvg: "362.38"
xref: DiffFormula: "C 19 H 22 O 7"
xref: DiffMono: "362.136553"
xref: Formula: "C 28 H 31 N 1 O 9"
xref: MassAvg: "525.55"
xref: MassMono: "525.199882"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:270"
is_obsolete: true

[Term]
id: MOD:01261
name: nucleophilic addtion to cytopiloyne - site S
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:15549660, Unimod:270#C]
synonym: "Cytopiloyne" RELATED PSI-MS-label []
synonym: "nucleophilic addtion to cytopiloyne" RELATED Unimod-description []
xref: DiffAvg: "362.38"
xref: DiffFormula: "C 19 H 22 O 7"
xref: DiffMono: "362.136553"
xref: Formula: "C 22 H 27 N 1 O 9"
xref: MassAvg: "449.46"
xref: MassMono: "449.168581"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:270"
is_obsolete: true

[Term]
id: MOD:01262
name: nucleophilic addition to cytopiloyne - site R
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:12590383, PubMed:15549660, Unimod:270#R]
synonym: "Cytopiloyne" RELATED PSI-MS-label []
synonym: "nucleophilic addtion to cytopiloyne" RELATED Unimod-description []
xref: DiffAvg: "362.38"
xref: DiffFormula: "C 19 H 22 O 7"
xref: DiffMono: "362.136553"
xref: Formula: "C 25 H 34 N 4 O 8"
xref: MassAvg: "518.57"
xref: MassMono: "518.237664"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:270"
is_obsolete: true

[Term]
id: MOD:01263
name: nucleophilic addtion to cytopiloyne - site K
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:15549660, Unimod:270#K]
synonym: "Cytopiloyne" RELATED PSI-MS-label []
synonym: "nucleophilic addtion to cytopiloyne" RELATED Unimod-description []
xref: DiffAvg: "362.38"
xref: DiffFormula: "C 19 H 22 O 7"
xref: DiffMono: "362.136553"
xref: Formula: "C 25 H 34 N 2 O 8"
xref: MassAvg: "490.55"
xref: MassMono: "490.231516"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:270"
is_obsolete: true

[Term]
id: MOD:01264
name: nucleophilic addtion to cytopiloyne - site C
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:15549660, Unimod:270#C]
synonym: "Cytopiloyne" RELATED PSI-MS-label []
synonym: "nucleophilic addtion to cytopiloyne" RELATED Unimod-description []
xref: DiffAvg: "362.38"
xref: DiffFormula: "C 19 H 22 O 7"
xref: DiffMono: "362.136553"
xref: Formula: "C 22 H 27 N 1 O 8 S 1"
xref: MassAvg: "465.52"
xref: MassMono: "465.145738"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:270"
is_obsolete: true

[Term]
id: MOD:01265
name: nucleophilic addtion to cytopiloyne - site P
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:15549660, Unimod:270#P]
synonym: "Cytopiloyne" RELATED PSI-MS-label []
synonym: "nucleophilic addtion to cytopiloyne" RELATED Unimod-description []
xref: DiffAvg: "362.38"
xref: DiffFormula: "C 19 H 22 O 7"
xref: DiffMono: "362.136553"
xref: Formula: "C 24 H 29 N 1 O 8"
xref: MassAvg: "459.50"
xref: MassMono: "459.189317"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:270"
is_obsolete: true

[Term]
id: MOD:01266
name: nucleophilic addition to cytopiloyne+H2O - site C
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:15549660, Unimod:271#C]
synonym: "Cytopiloyne+water" RELATED PSI-MS-label []
synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED Unimod-description []
xref: DiffAvg: "380.39"
xref: DiffFormula: "C 19 H 24 O 8"
xref: DiffMono: "380.147118"
xref: Formula: "C 22 H 29 N 1 O 9 S 1"
xref: MassAvg: "483.53"
xref: MassMono: "483.156303"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:271"
is_obsolete: true

[Term]
id: MOD:01267
name: nucleophilic addition to cytopiloyne+H2O - site K
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:11746907, PubMed:15549660, Unimod:271#K]
synonym: "Cytopiloyne+water" RELATED PSI-MS-label []
synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED Unimod-description []
xref: DiffAvg: "380.39"
xref: DiffFormula: "C 19 H 24 O 8"
xref: DiffMono: "380.147118"
xref: Formula: "C 25 H 36 N 2 O 9"
xref: MassAvg: "508.57"
xref: MassMono: "508.242081"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:271"
is_obsolete: true

[Term]
id: MOD:01268
name: nucleophilic addition to cytopiloyne+H2O - site T
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:15549660, Unimod:271#T]
synonym: "Cytopiloyne+water" RELATED PSI-MS-label []
synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED Unimod-description []
xref: DiffAvg: "380.39"
xref: DiffFormula: "C 19 H 24 O 8"
xref: DiffMono: "380.147118"
xref: Formula: "C 23 H 31 N 1 O 10"
xref: MassAvg: "481.50"
xref: MassMono: "481.194796"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:271"
is_obsolete: true

[Term]
id: MOD:01269
name: nucleophilic addition to cytopiloyne+H2O - site R
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:15549660, Unimod:271#R]
synonym: "Cytopiloyne+water" RELATED PSI-MS-label []
synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED Unimod-description []
xref: DiffAvg: "380.39"
xref: DiffFormula: "C 19 H 24 O 8"
xref: DiffMono: "380.147118"
xref: Formula: "C 25 H 36 N 4 O 9"
xref: MassAvg: "536.58"
xref: MassMono: "536.248229"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:271"
is_obsolete: true

[Term]
id: MOD:01270
name: nucleophilic addition to cytopiloyne+H2O - site S
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:14670044, PubMed:15549660, Unimod:271#S]
synonym: "Cytopiloyne+water" RELATED PSI-MS-label []
synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED Unimod-description []
xref: DiffAvg: "380.39"
xref: DiffFormula: "C 19 H 24 O 8"
xref: DiffMono: "380.147118"
xref: Formula: "C 22 H 29 N 1 O 10"
xref: MassAvg: "467.47"
xref: MassMono: "467.179146"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:271"
is_obsolete: true

[Term]
id: MOD:01271
name: nucleophilic addition to cytopiloyne+H2O - site Y
def: "OBSOLETE because there is no evidence in the literature of covalent modification of polypeptides with cytopiloyne or cytopiloyne+H2O.  Modifications could potentially happen, but are not experimentally verified. [PMT] modification from Unimod Chemical derivative -" [PubMed:15549660, Unimod:271#Y]
synonym: "Cytopiloyne+water" RELATED PSI-MS-label []
synonym: "nucleophilic addition to cytopiloyne+H2O" RELATED Unimod-description []
xref: DiffAvg: "380.39"
xref: DiffFormula: "C 19 H 24 O 8"
xref: DiffMono: "380.147118"
xref: Formula: "C 28 H 33 N 1 O 10"
xref: MassAvg: "543.57"
xref: MassMono: "543.210446"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:271"
is_obsolete: true

[Term]
id: MOD:01272
name: iminobiotinylation - site K
def: "modification from Unimod Chemical derivative -" [PubMed:9750125, Unimod:89#K]
synonym: "Iminobiotin" RELATED PSI-MS-label []
synonym: "Iminobiotinylation" RELATED Unimod-description []
xref: DiffAvg: "225.31"
xref: DiffFormula: "C 10 H 15 N 3 O 1 S 1"
xref: DiffMono: "225.093583"
xref: Formula: "C 16 H 27 N 5 O 2 S 1"
xref: MassAvg: "353.49"
xref: MassMono: "353.188546"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:89"
is_a: MOD:00467 ! iminobiotinyl modified residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01273
name: O-[4-(2-aminoethyl)benzenesulfonyl] serine
def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-serine residue." [PubMed:15283597, PubMed:8597590, Unimod:276#S]
synonym: "AEBS" RELATED PSI-MS-label []
synonym: "Aminoethylbenzenesulfonylation" RELATED Unimod-description []
xref: DiffAvg: "183.23"
xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1"
xref: DiffMono: "183.035400"
xref: Formula: "C 11 H 14 N 2 O 4 S 1"
xref: MassAvg: "270.30"
xref: MassMono: "270.067428"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:276"
is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01274
name: N'-[4-(2-aminoethyl)benzenesulfonyl] derivatized histidine
def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-histidine residue." [PubMed:8597590, Unimod:276#H]
synonym: "AEBS" RELATED PSI-MS-label []
synonym: "Aminoethylbenzenesulfonylation" RELATED Unimod-description []
xref: DiffAvg: "183.23"
xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1"
xref: DiffMono: "183.035400"
xref: Formula: "C 14 H 16 N 4 O 3 S 1"
xref: MassAvg: "320.37"
xref: MassMono: "320.094311"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:276"
is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:01275
name: N6-[4-(2-aminoethyl)benzenesulfonyl]lysine
def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-lysine residue." [PubMed:8597590, Unimod:276#K]
synonym: "AEBS" RELATED PSI-MS-label []
synonym: "Aminoethylbenzenesulfonylation" RELATED Unimod-description []
xref: DiffAvg: "183.23"
xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1"
xref: DiffMono: "183.035400"
xref: Formula: "C 14 H 21 N 3 O 3 S 1"
xref: MassAvg: "311.40"
xref: MassMono: "311.130363"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:276"
is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01276
name: O4'-[4-(2-aminoethyl)benzenesulfonyl]tyrosine
def: "A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-tyrosine residue." [PubMed:10906242, PubMed:8597590, Unimod:276#Y]
synonym: "AEBS" RELATED PSI-MS-label []
synonym: "Aminoethylbenzenesulfonylation" RELATED Unimod-description []
xref: DiffAvg: "183.23"
xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1"
xref: DiffMono: "183.035400"
xref: Formula: "C 17 H 18 N 2 O 4 S 1"
xref: MassAvg: "346.40"
xref: MassMono: "346.098728"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:276"
is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:01277
name: crotonylated L-cysteine
def: "modification from Unimod Other -" [PubMed:11283024, Unimod:253#C]
synonym: "Crotonaldehyde" RELATED PSI-MS-label []
synonym: "Crotonaldehyde" RELATED Unimod-description []
xref: DiffAvg: "70.09"
xref: DiffFormula: "C 4 H 6 O 1"
xref: DiffMono: "70.041865"
xref: Formula: "C 7 H 11 N 1 O 2 S 1"
xref: MassAvg: "173.23"
xref: MassMono: "173.051050"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:253"
is_a: MOD:00576 ! crotonylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01278
name: crotonylated L-lysine
def: "modification from Unimod Other -" [PubMed:11283024, Unimod:253#K]
synonym: "Crotonaldehyde" RELATED PSI-MS-label []
synonym: "Crotonaldehyde" RELATED Unimod-description []
xref: DiffAvg: "70.09"
xref: DiffFormula: "C 4 H 6 O 1"
xref: DiffMono: "70.041865"
xref: Formula: "C 10 H 18 N 2 O 2"
xref: MassAvg: "198.27"
xref: MassMono: "198.136828"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:253"
is_a: MOD:00576 ! crotonylated residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01279
name: crotonylated L-histidine
def: "modification from Unimod Other -" [PubMed:11283024, PubMed:1443554, Unimod:253#H]
synonym: "Crotonaldehyde" RELATED PSI-MS-label []
synonym: "Crotonaldehyde" RELATED Unimod-description []
xref: DiffAvg: "70.09"
xref: DiffFormula: "C 4 H 6 O 1"
xref: DiffMono: "70.041865"
xref: Formula: "C 10 H 13 N 3 O 2"
xref: MassAvg: "207.23"
xref: MassMono: "207.100777"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:253"
is_a: MOD:00576 ! crotonylated residue
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:01280
name: EDT-iodo-PEO-biotin - site T
def: "modification from Unimod Chemical derivative -" [PubMed:11857757, PubMed:12175151, Unimod:118#T]
synonym: "EDT-iodo-PEO-biotin" RELATED Unimod-description []
synonym: "EDT-iodoacetyl-PEO-biotin" RELATED PSI-MS-label []
xref: DiffAvg: "490.70"
xref: DiffFormula: "C 20 H 34 N 4 O 4 S 3"
xref: DiffMono: "490.174219"
xref: Formula: "C 24 H 41 N 5 O 6 S 3"
xref: MassAvg: "591.80"
xref: MassMono: "591.221897"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:118"
is_a: MOD:00490 ! EDT-iodo-PEO-biotin
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01281
name: EDT-iodo-PEO-biotin - site S
def: "modification from Unimod Chemical derivative -" [PubMed:16335955, Unimod:118#S]
synonym: "EDT-iodo-PEO-biotin" RELATED Unimod-description []
synonym: "EDT-iodoacetyl-PEO-biotin" RELATED PSI-MS-label []
xref: DiffAvg: "490.70"
xref: DiffFormula: "C 20 H 34 N 4 O 4 S 3"
xref: DiffMono: "490.174219"
xref: Formula: "C 23 H 39 N 5 O 6 S 3"
xref: MassAvg: "577.77"
xref: MassMono: "577.206247"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:118"
is_a: MOD:00490 ! EDT-iodo-PEO-biotin
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01282
name: acrolein addition +56 - site H
def: "OBSOLETE because this modification is not supported by the linked literature [PMT]" [PubMed:10825247, PubMed:15541752, Unimod:206#H]
synonym: "Acrolein addition +56" RELATED Unimod-description []
synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label []
xref: DiffAvg: "56.06"
xref: DiffFormula: "C 3 H 4 O 1"
xref: DiffMono: "56.026215"
xref: Formula: "C 9 H 11 N 3 O 2"
xref: MassAvg: "193.21"
xref: MassMono: "193.085127"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:206"
is_obsolete: true

[Term]
id: MOD:01283
name: acrolein addition +56 - site K
def: "OBSOLETE because this modification is not supported by the linked literature [PMT]" [PubMed:10825247, PubMed:15541752, Unimod:206#K]
synonym: "Acrolein addition +56" RELATED Unimod-description []
synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label []
xref: DiffAvg: "56.06"
xref: DiffFormula: "C 3 H 4 O 1"
xref: DiffMono: "56.026215"
xref: Formula: "C 9 H 16 N 2 O 2"
xref: MassAvg: "184.24"
xref: MassMono: "184.121178"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:206"
is_obsolete: true

[Term]
id: MOD:01284
name: acrolein addition +56 - site C
def: "OBSOLETE because this modification is not supported by the linked literature [PMT]" [PubMed:10825247, PubMed:15541752, PubMed:9254591, Unimod:206#C]
synonym: "Acrolein addition +56" RELATED Unimod-description []
synonym: "Delta:H(4)C(3)O(1)" RELATED PSI-MS-label []
xref: DiffAvg: "56.06"
xref: DiffFormula: "C 3 H 4 O 1"
xref: DiffMono: "56.026215"
xref: Formula: "C 6 H 9 N 1 O 2 S 1"
xref: MassAvg: "159.20"
xref: MassMono: "159.035400"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:206"
is_obsolete: true

[Term]
id: MOD:01285
name: 6x(13)C,1x(15)N labeled L-leucine
def: "A protein modification that effectively converts an L-leucine residue to 6x(13)C,1x(15)N isotope labeled L-leucine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, Unimod:695#L]
synonym: "13C(6) 15N(1) Silac label" RELATED Unimod-description []
synonym: "Label:13C(6)15N(1)" RELATED PSI-MS-label []
xref: DiffAvg: "7.02"
xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -1 (15)N 1"
xref: DiffMono: "7.017164"
xref: Formula: "(13)C 6 H 11 (15)N 1 O 1"
xref: MassAvg: "120.10"
xref: MassMono: "120.101228"
xref: Origin: "L"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:695"
is_a: MOD:00911 ! modified L-leucine residue
is_a: MOD:01370 ! 6x(13)C,1x(15)N labeled residue

[Term]
id: MOD:01286
name: 6x(13)C,1x(15)N labeled L-isoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to 6x(13)C,1x(15)N isotope labeled L-isoleucine." [PubMed:11857757, PubMed:11999733, PubMed:12175151, Unimod:695#I]
synonym: "13C(6) 15N(1) Silac label" RELATED Unimod-description []
synonym: "Label:13C(6)15N(1)" RELATED PSI-MS-label []
xref: DiffAvg: "7.02"
xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -1 (15)N 1"
xref: DiffMono: "7.017164"
xref: Formula: "(13)C 6 H 11 (15)N 1 O 1"
xref: MassAvg: "120.10"
xref: MassMono: "120.101228"
xref: Origin: "I"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:695"
is_a: MOD:00910 ! modified L-isoleucine residue
is_a: MOD:01370 ! 6x(13)C,1x(15)N labeled residue

[Term]
id: MOD:01287
name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form - site K
def: "modification from Unimod Isotopic label -" [PubMed:11857757, PubMed:15602776, Unimod:364#K]
synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form" RELATED Unimod-description []
synonym: "ICPL:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "111.04"
xref: DiffFormula: "(13)C 6 H 3 N 1 O 1"
xref: DiffMono: "111.041593"
xref: Formula: "C 6 (13)C 6 H 15 N 3 O 2"
xref: MassAvg: "239.14"
xref: MassMono: "239.136556"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:364"
is_a: MOD:00789 ! Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01288
name: acetaldehyde +28 - site H
def: "OBSOLETE because this is not supported by the literature [PMT]" [Unimod:255#H]
synonym: "Acetaldehyde +28" RELATED Unimod-description []
synonym: "Delta:H(4)C(2)" RELATED PSI-MS-label []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4"
xref: DiffMono: "28.031300"
xref: Formula: "C 8 H 11 N 3 O 1"
xref: MassAvg: "165.20"
xref: MassMono: "165.090212"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:255"
is_obsolete: true

[Term]
id: MOD:01289
name: acetaldehyde +28 - site K
def: "OBSOLETE because this is not supported by the literature [PMT]" [Unimod:255#K]
synonym: "Acetaldehyde +28" RELATED Unimod-description []
synonym: "Delta:H(4)C(2)" RELATED PSI-MS-label []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4"
xref: DiffMono: "28.031300"
xref: Formula: "C 8 H 16 N 2 O 1"
xref: MassAvg: "156.23"
xref: MassMono: "156.126263"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:255"
is_obsolete: true

[Term]
id: MOD:01290
name: dihydroxylated residue - site F
def: "OBSOLETE because redundant and identical to MOD:00465. Remap to MOD:00465." [PubMed:11857757, PubMed:12175151, PubMed:12686488, PubMed:9252331, Unimod:425]
synonym: "dihydroxy" RELATED Unimod-description []
synonym: "Dioxidation" RELATED PSI-MS-label []
xref: DiffAvg: "32.00"
xref: DiffFormula: "O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 9 H 9 N 1 O 3"
xref: MassAvg: "179.17"
xref: MassMono: "179.058243"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:425"
xref: Remap: "MOD:00465"
is_obsolete: true

[Term]
id: MOD:01291
name: dihydroxylated residue - site W
def: "OBSOLETE because redundant and identical to MOD:00464. Remap to MOD:00464." [PubMed:12643539, PubMed:12686488, PubMed:6273432, PubMed:9252331, Unimod:425]
synonym: "dihydroxy" RELATED Unimod-description []
synonym: "Dioxidation" RELATED PSI-MS-label []
xref: DiffAvg: "32.00"
xref: DiffFormula: "O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 11 H 10 N 2 O 3"
xref: MassAvg: "218.21"
xref: MassMono: "218.069142"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00464"
xref: Unimod: "Unimod:425"
is_obsolete: true

[Term]
id: MOD:01292
name: dimethylation of proline residue
def: "OBSOLETE because redundant and identical to MOD:00075. Map to MOD:00075." [Unimod:529]
synonym: "Delta:H(5)C(2)" RELATED PSI-MS-label []
synonym: "Dimethylation of proline residue" RELATED Unimod-description []
xref: DiffAvg: "29.06"
xref: DiffFormula: "C 2 H 5"
xref: DiffMono: "29.039125"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:00075"
xref: Unimod: "Unimod:529"
is_obsolete: true

[Term]
id: MOD:01293
name: 1x(18)O labeled deamidated L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O." [OMSSA:139, PubMed:8382902, Unimod:366#N]
subset: PSI-MOD-slim
synonym: "Deamidated:18O(1)" RELATED PSI-MS-label []
synonym: "Deamidation in presence of O18" RELATED Unimod-description []
synonym: "oxy18" EXACT OMSSA-label []
xref: DiffAvg: "2.99"
xref: DiffFormula: "H -1 N -1 (18)O 1"
xref: DiffMono: "2.988262"
xref: Formula: "C 4 H 5 N 1 (16)O 2 (18)O 1"
xref: MassAvg: "117.03"
xref: MassMono: "117.031189"
xref: Origin: "N"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:366"
is_a: MOD:00852 ! 1x(18)O labeled deamidated residue
relationship: derives_from MOD:00684 ! deamidated L-asparagine

[Term]
id: MOD:01294
name: deamidation in presence of O18 -site Q
def: "OBSOLETE identical and redundant with MOD:00791. Remap to MOD:00791." [PubMed:8382902]
synonym: "Deamidated:18O(1)" RELATED PSI-MS-label []
synonym: "Deamidation in presence of O18" RELATED Unimod-description []
xref: DiffAvg: "2.99"
xref: DiffFormula: "H -1 N -1 (18)O 1"
xref: DiffMono: "2.988262"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "Q"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00791"
is_obsolete: true

[Term]
id: MOD:01295
name: monosodium L-aspartate
def: "A protein modification that effectively converts an L-aspartic acid residue to monosodium L-aspartate." [PubMed:12216740, Unimod:30#D]
subset: PSI-MOD-slim
synonym: "Cation:Na" RELATED PSI-MS-label []
synonym: "Na1Asp" EXACT PSI-MOD-label []
synonym: "Sodium adduct" RELATED Unimod-description []
xref: DiffAvg: "21.98"
xref: DiffFormula: "H -1 Na 1"
xref: DiffMono: "21.981944"
xref: Formula: "C 4 H 4 N 1 Na 1 O 3"
xref: MassAvg: "137.07"
xref: MassMono: "137.008887"
xref: Origin: "D"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:30"
is_a: MOD:00423 ! monosodium salt
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:01296
name: monosodium L-glutamate
def: "A protein modification that effectively converts an L-glutamic acid residue to monosodium L-glutamate." [PubMed:12216740, Unimod:30#E]
subset: PSI-MOD-slim
synonym: "Cation:Na" RELATED PSI-MS-label []
synonym: "MSG" EXACT PSI-MOD-alternate []
synonym: "Na1Glu" EXACT PSI-MOD-label []
synonym: "Sodium adduct" RELATED Unimod-description []
xref: DiffAvg: "21.98"
xref: DiffFormula: "H -1 Na 1"
xref: DiffMono: "21.981944"
xref: Formula: "C 5 H 6 N 1 Na 1 O 3"
xref: MassAvg: "151.10"
xref: MassMono: "151.024537"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:30"
is_a: MOD:00423 ! monosodium salt
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:01297
name: 5x(13)C labeled L-proline
def: "A protein modification that effectively converts an L-proline residue to 5x(13)C labeled L-proline." [PubMed:12716131, Unimod:772#P]
comment: In PubMed:12716131, fully (13)C labeled proline apparently resulted from the catabolic conversion of (13)C labeled L-arginine during SILAC.
synonym: "13C(5) Silac label" RELATED Unimod-description []
synonym: "Label:13C(5)" RELATED PSI-MS-label []
xref: DiffAvg: "5.02"
xref: DiffFormula: "(12)C -5 (13)C 5"
xref: DiffMono: "5.016774"
xref: Formula: "(13)C 5 H 7 N 1 O 1"
xref: MassAvg: "102.07"
xref: MassMono: "102.069538"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:772"
is_a: MOD:00915 ! modified L-proline residue
is_a: MOD:01832 ! 5x(13)C-labeled residue

[Term]
id: MOD:01298
name: reduced cysteine 4-hydroxynonenal adduct
def: "A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:15133838, Unimod:335#C]
comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG].
synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label []
synonym: "reduced 4-Hydroxynonenal" RELATED Unimod-description []
xref: DiffAvg: "158.24"
xref: DiffFormula: "C 9 H 18 O 2"
xref: DiffMono: "158.130680"
xref: Formula: "C 12 H 23 N 1 O 3 S 1"
xref: MassAvg: "261.38"
xref: MassMono: "261.139865"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:335"
is_a: MOD:00642 ! reduced 4-hydroxynonenal adduct
is_a: MOD:00905 ! modified L-cysteine residue
relationship: derives_from MOD:01237 ! cysteine 4-hydroxynonenal adduct

[Term]
id: MOD:01299
name: reduced lysine 4-hydroxynonenal adduct
def: "A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:12148805, PubMed:15133838, Unimod:335#K]
comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG].
synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label []
synonym: "reduced 4-Hydroxynonenal" RELATED Unimod-description []
xref: DiffAvg: "158.24"
xref: DiffFormula: "C 9 H 18 O 2"
xref: DiffMono: "158.130680"
xref: Formula: "C 15 H 30 N 2 O 3"
xref: MassAvg: "286.42"
xref: MassMono: "286.225643"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:335"
is_a: MOD:00642 ! reduced 4-hydroxynonenal adduct
is_a: MOD:00912 ! modified L-lysine residue
relationship: derives_from MOD:01238 ! lysine 4-hydroxynonenal adduct

[Term]
id: MOD:01300
name: reduced histidine 4-hydroxynonenal adduct
def: "A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4." [PubMed:11910026, PubMed:12148805, PubMed:15133838, Unimod:335#H]
comment: 4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG].
synonym: "HNE+Delta:H(2)" RELATED PSI-MS-label []
synonym: "reduced 4-Hydroxynonenal" RELATED Unimod-description []
xref: DiffAvg: "158.24"
xref: DiffFormula: "C 9 H 18 O 2"
xref: DiffMono: "158.130680"
xref: Formula: "C 15 H 25 N 3 O 3"
xref: MassAvg: "295.38"
xref: MassMono: "295.189592"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:335"
is_a: MOD:00642 ! reduced 4-hydroxynonenal adduct
is_a: MOD:00909 ! modified L-histidine residue
relationship: derives_from MOD:01239 ! histidine 4-hydroxynonenal adduct

[Term]
id: MOD:01301
name: methylamine Michael addition derivatized threonine
def: "A protein modification that effectively converts an L-threonine residue to 2-amino-3-(methylamino)butanoic acid." [PubMed:11743741, Unimod:337#T]
comment: In PubMed:11743741 phosphothreonine is converted to dehydrobutyrine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)butanoic acid.
synonym: "Methylamine" RELATED PSI-MS-label []
synonym: "Michael addition with methylamine" RELATED Unimod-description []
xref: DiffAvg: "13.04"
xref: DiffFormula: "C 1 H 3 N 1 O -1"
xref: DiffMono: "13.031634"
xref: Formula: "C 5 H 10 N 2 O 1"
xref: MassAvg: "114.15"
xref: MassMono: "114.079313"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:337"
is_a: MOD:00643 ! methylamine Michael addition derivatized residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01302
name: methylamine Michael addition derivatized serine
def: "A protein modification that effectively converts an L-serine residue to 2-amino-3-(methylamino)propanoic acid." [PubMed:11743741, Unimod:337#S]
comment: In PubMed:11743741 phosphoserine is converted to dehydroalanine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)propanoic acid.
synonym: "Methylamine" RELATED PSI-MS-label []
synonym: "Michael addition with methylamine" RELATED Unimod-description []
xref: DiffAvg: "13.04"
xref: DiffFormula: "C 1 H 3 N 1 O -1"
xref: DiffMono: "13.031634"
xref: Formula: "C 4 H 8 N 2 O 1"
xref: MassAvg: "100.12"
xref: MassMono: "100.063663"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:337"
is_a: MOD:00643 ! methylamine Michael addition derivatized residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01303
name: N4-hexosaminylated asparagine
def: "A protein modification that effectively converts an L-asparagine residue to an N4-hexosaminyl-L-asparagine." [PubMed:11467524, Unimod:454#N]
comment: The natural modifications are N4-(N-acetylamino)galactosyl-L-asparagine (MOD:00832) or N4-(N-acetylamino)glucosyl-L-asparagine (MOD:00831) [JSG].
synonym: "HexN" RELATED PSI-MS-label []
synonym: "Hexosamine" RELATED Unimod-description []
xref: DiffAvg: "161.16"
xref: DiffFormula: "C 6 H 11 N 1 O 4"
xref: DiffMono: "161.068808"
xref: Formula: "C 10 H 17 N 3 O 6"
xref: MassAvg: "275.26"
xref: MassMono: "275.111735"
xref: Origin: "N"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:454"
is_a: MOD:00160 ! N4-glycosyl-L-asparagine
is_a: MOD:00876 ! hexosaminylated residue

[Term]
id: MOD:01304
name: N6-hexosaminylated lysine
def: "A protein modification that effectively converts an L-lysine residue to an N4-hexosaminyl-L-lysine, as a synthetic peptide protectting group." [Unimod:454#K]
synonym: "HexN" RELATED PSI-MS-label []
synonym: "Hexosamine" RELATED Unimod-description []
xref: DiffAvg: "161.16"
xref: DiffFormula: "C 6 H 11 N 1 O 4"
xref: DiffMono: "161.068808"
xref: Formula: "C 12 H 23 N 3 O 5"
xref: MassAvg: "289.33"
xref: MassMono: "289.163771"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:454"
is_a: MOD:00876 ! hexosaminylated residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01305
name: N1'-hexosaminylated tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to N1'-hexosaminyl-L-tryptophan." [Unimod:454#W]
comment: The natural modification is N1'-mannosyl-L-tryptophan (MOD:00165) [JSG].
synonym: "HexN" RELATED PSI-MS-label []
synonym: "Hexosamine" RELATED Unimod-description []
xref: DiffAvg: "161.16"
xref: DiffFormula: "C 6 H 11 N 1 O 4"
xref: DiffMono: "161.068808"
xref: Formula: "C 17 H 21 N 3 O 5"
xref: MassAvg: "347.37"
xref: MassMono: "347.148121"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:454"
is_a: MOD:00876 ! hexosaminylated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:01306
name: O-hexosaminylated threonine
def: "A protein modification that effectively converts an L-threonine residue to O-hexosaminyl-L-threonine." [Unimod:454#T]
comment: The natural modifications are O-(N-acetylaminogalactosyl)-L-threonine (MOD:00164) or O-(N-acetylaminoglucosyl)-L-threonine (MOD:00806) [JSG].
synonym: "HexN" RELATED PSI-MS-label []
synonym: "Hexosamine" RELATED Unimod-description []
xref: DiffAvg: "161.16"
xref: DiffFormula: "C 6 H 11 N 1 O 4"
xref: DiffMono: "161.068808"
xref: Formula: "C 10 H 18 N 2 O 6"
xref: MassAvg: "262.26"
xref: MassMono: "262.116486"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:454"
is_a: MOD:00005 ! O-glycosyl-L-threonine
is_a: MOD:00876 ! hexosaminylated residue

[Term]
id: MOD:01307
name: thiophosphate labeled with biotin-HPDP -site S
def: "modification from Unimod Chemical derivative -" [Unimod:332#S]
synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label []
synonym: "thiophosphate labeled with biotin-HPDP" RELATED Unimod-description []
xref: DiffAvg: "525.66"
xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3"
xref: DiffMono: "525.142895"
xref: Formula: "C 22 H 39 N 5 O 7 P 1 S 3"
xref: MassAvg: "612.74"
xref: MassMono: "612.174923"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:332"
is_a: MOD:00639 ! thiophosphate labeled with biotin-HPDP
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01308
name: thiophosphate labeled with biotin-HPDP -site T
def: "modification from Unimod Chemical derivative -" [Unimod:332#T]
synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label []
synonym: "thiophosphate labeled with biotin-HPDP" RELATED Unimod-description []
xref: DiffAvg: "525.66"
xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3"
xref: DiffMono: "525.142895"
xref: Formula: "C 23 H 41 N 5 O 7 P 1 S 3"
xref: MassAvg: "626.76"
xref: MassMono: "626.190573"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:332"
is_a: MOD:00639 ! thiophosphate labeled with biotin-HPDP
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01309
name: thiophosphate labeled with biotin-HPDP - site Y
def: "modification from Unimod Chemical derivative - " [Unimod:332#Y]
synonym: "Thiophos-S-S-biotin" RELATED PSI-MS-label []
synonym: "thiophosphate labeled with biotin-HPDP" RELATED Unimod-description []
xref: DiffAvg: "525.66"
xref: DiffFormula: "C 19 H 34 N 4 O 5 P 1 S 3"
xref: DiffMono: "525.142895"
xref: Formula: "C 28 H 43 N 5 O 7 P 1 S 3"
xref: MassAvg: "688.83"
xref: MassMono: "688.206223"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:332"
is_a: MOD:00639 ! thiophosphate labeled with biotin-HPDP
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:01310
name: quaternary amine labeling reagent light form N6-L-lysine
def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent light form group." [PubMed:11857757, Unimod:60#K]
synonym: "GIST-Quat" RELATED PSI-MS-label []
synonym: "Quaternary amine labeling reagent light form (N-term & K)" RELATED Unimod-description []
xref: DiffAvg: "59.07"
xref: DiffFormula: "C 3 (1)H 9 N 1"
xref: DiffMono: "59.073499"
xref: Formula: "C 9 (1)H 21 N 3 O 1"
xref: MassAvg: "187.17"
xref: MassMono: "187.168462"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:60"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:01311
name: quaternary amine labeling reagent heavy form (+3amu) N6-L-lysine
def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+3amu) form group." [PubMed:11698400, PubMed:11857757, PubMed:11914093, Unimod:61#K]
synonym: "GIST-Quat:2H(3)" RELATED PSI-MS-label []
synonym: "Quaternary amine labeling reagent heavy (+3amu) form, N-term & K" RELATED Unimod-description []
xref: DiffAvg: "62.09"
xref: DiffFormula: "C 3 (1)H 6 (2)H 3 N 1"
xref: DiffMono: "62.092330"
xref: Formula: "C 9 (1)H 18 (2)H 3 N 3 O 1"
xref: MassAvg: "190.19"
xref: MassMono: "190.187293"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:61"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:01312
name: quaternary amine labeling reagent heavy form (+6amu) N6-L-lysine
def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+6amu) form group." [PubMed:11857757, Unimod:62#K]
comment: Apparently incorrect parent [JSG].
synonym: "GIST-Quat:2H(6)" RELATED PSI-MS-label []
synonym: "Quaternary amine labeling reagent heavy form (+6amu), N-term & K" RELATED Unimod-description []
xref: DiffAvg: "65.11"
xref: DiffFormula: "C 3 (1)H 3 (2)H 6 N 1"
xref: DiffMono: "65.111160"
xref: Formula: "C 9 (1)H 15 (2)H 6 N 3 O 1"
xref: MassAvg: "193.21"
xref: MassMono: "193.206123"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:62"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:01313
name: quaternary amine labeling reagent heavy form (+9amu) N6-L-lysine
def: "A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+9amu) form group." [PubMed:11857757, Unimod:63#K]
synonym: "GIST-Quat:2H(9)" RELATED PSI-MS-label []
synonym: "Quaternary amine labeling reagent heavy form (+9amu), N-term & K" RELATED Unimod-description []
xref: DiffAvg: "68.13"
xref: DiffFormula: "C 3 (2)H 9 N 1"
xref: DiffMono: "68.129990"
xref: Formula: "C 9 (1)H 12 (2)H 9 N 3 O 1"
xref: MassAvg: "196.22"
xref: MassMono: "196.224953"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:63"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:01314
name: 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine." [PubMed:11857757, PubMed:12175151, PubMed:12716131, Unimod:64#K]
synonym: "Succinic anhydride labeling reagent light form (K)" RELATED Unimod-description []
synonym: "Succinyl" RELATED PSI-MS-label []
xref: DiffAvg: "100.02"
xref: DiffFormula: "(12)C 4 (1)H 4 O 3"
xref: DiffMono: "100.016044"
xref: Formula: "(12)C 10 H 16 N 2 O 4"
xref: MassAvg: "228.11"
xref: MassMono: "228.111007"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:64"
relationship: derives_from MOD:01819 ! N6-succinyl-L-lysine
is_a: MOD:00670 ! N-acylated residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:01315
name: 4x(2)H labeled N6-succinyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 4x(2)H-labeled N6-succinyl-L-lysine." [PubMed:11344537, PubMed:11857757, PubMed:12175151, PubMed:15189151, Unimod:65#K]
synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4H2), N-term & K" RELATED Unimod-description []
synonym: "Succinyl:2H(4)" RELATED PSI-MS-label []
xref: DiffAvg: "104.04"
xref: DiffFormula: "C 4 (2)H 4 O 3"
xref: DiffMono: "104.041151"
xref: Formula: "C 10 (1)H 12 (2)H 4 N 2 O 4"
xref: MassAvg: "232.14"
xref: MassMono: "232.136114"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:65"
relationship: derives_from MOD:01819 ! N6-succinyl-L-lysine
is_a: MOD:00670 ! N-acylated residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:01316
name: 4x(13)C labeled N6-succinyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 4x(13)C labeled N6-succinyl-L-lysine." [PubMed:11344537, PubMed:11857757, PubMed:12175151, PubMed:15189151, Unimod:66#K]
synonym: "Succinic anhydride labeling reagent, heavy form (+4amu, 4C13),  K" RELATED Unimod-description []
synonym: "Succinyl:13C(4)" RELATED PSI-MS-label []
xref: DiffAvg: "104.03"
xref: DiffFormula: "(13)C 4 H 4 O 3"
xref: DiffMono: "104.029463"
xref: Formula: "(12)C 6 (13)C 4 H 16 N 2 O 4"
xref: MassAvg: "232.12"
xref: MassMono: "232.124426"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:66"
relationship: derives_from MOD:01819 ! N6-succinyl-L-lysine
is_a: MOD:00670 ! N-acylated residue
is_a: MOD:01428 ! (13)C isotope tagged reagent

[Term]
id: MOD:01317
name: phosphorylation to amine thiol - site T
def: "modification from Unimod Chemical derivative -" [PubMed:12216740, Unimod:178#T]
synonym: "DAET" RELATED PSI-MS-label []
synonym: "phosphorylation to amine thiol" RELATED Unimod-description []
xref: DiffAvg: "87.18"
xref: DiffFormula: "C 4 H 9 N 1 O -1 S 1"
xref: DiffMono: "87.050656"
xref: Formula: "C 8 H 16 N 2 O 1 S 1"
xref: MassAvg: "188.29"
xref: MassMono: "188.098334"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:178"
is_a: MOD:00535 ! phosphorylation to amine thiol
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01318
name: phosphorylation to amine thiol - site S
def: "modification from Unimod Chemical derivative -" [PubMed:11510821, PubMed:12216740, PubMed:12422359, Unimod:178#S]
synonym: "DAET" RELATED PSI-MS-label []
synonym: "phosphorylation to amine thiol" RELATED Unimod-description []
xref: DiffAvg: "87.18"
xref: DiffFormula: "C 4 H 9 N 1 O -1 S 1"
xref: DiffMono: "87.050656"
xref: Formula: "C 7 H 14 N 2 O 1 S 1"
xref: MassAvg: "174.26"
xref: MassMono: "174.082684"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:178"
is_a: MOD:00535 ! phosphorylation to amine thiol
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01319
name: Michael addition of BHT quinone methide to histidine
def: "modification from Unimod Other" [PubMed:11510821, PubMed:12422359, PubMed:9448752, Unimod:176#H]
comment: Secondary adduct, much less common than cysteine. [Unimod]
synonym: "BHT" RELATED PSI-MS-label []
synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED Unimod-description []
xref: DiffAvg: "218.34"
xref: DiffFormula: "C 15 H 22 O 1"
xref: DiffMono: "218.167065"
xref: Formula: "C 21 H 29 N 3 O 2"
xref: MassAvg: "355.48"
xref: MassMono: "355.225977"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:176"
is_a: MOD:00534 ! Michael addition of BHT quinone methide to cysteine and lysine
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:01320
name: Michael addition of BHT quinone methide to lysine
def: "modification from Unimod Other" [PubMed:16078144, PubMed:9448752, Unimod:176#K]
comment: Secondary adduct, much less common than cysteine. [Unimod]
synonym: "BHT" RELATED PSI-MS-label []
synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED Unimod-description []
xref: DiffAvg: "218.34"
xref: DiffFormula: "C 15 H 22 O 1"
xref: DiffMono: "218.167065"
xref: Formula: "C 21 H 34 N 2 O 2"
xref: MassAvg: "346.51"
xref: MassMono: "346.262028"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:176"
is_a: MOD:00534 ! Michael addition of BHT quinone methide to cysteine and lysine
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01321
name: Michael addition of BHT quinone methide to cysteine
def: "modification from Unimod Other" [PubMed:11510821, PubMed:12422359, PubMed:9448752, Unimod:176#C]
comment: Primary adduct formed. [Unimod]
synonym: "BHT" RELATED PSI-MS-label []
synonym: "Michael addition of BHT quinone methide to Cysteine and Lysine" RELATED Unimod-description []
xref: DiffAvg: "218.34"
xref: DiffFormula: "C 15 H 22 O 1"
xref: DiffMono: "218.167065"
xref: Formula: "C 18 H 27 N 1 O 2 S 1"
xref: MassAvg: "321.48"
xref: MassMono: "321.176250"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:176"
is_a: MOD:00534 ! Michael addition of BHT quinone methide to cysteine and lysine
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01322
name: propionaldehyde +40 - site K
def: "OBSOLETE because not supported by the linked literature [PMT]. modification from Unimod Other -" [PubMed:15549660, Unimod:256#K]
synonym: "Delta:H(4)C(3)" RELATED PSI-MS-label []
synonym: "Propionaldehyde +40" RELATED Unimod-description []
xref: DiffAvg: "40.06"
xref: DiffFormula: "C 3 H 4"
xref: DiffMono: "40.031300"
xref: Formula: "C 9 H 16 N 2 O 1"
xref: MassAvg: "168.24"
xref: MassMono: "168.126263"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:256"
is_obsolete: true

[Term]
id: MOD:01323
name: propionaldehyde +40 - site H
def: "OBSOLETE because not supported by the linked literature [PMT]. modification from Unimod Other -" [Unimod:256#H]
synonym: "Delta:H(4)C(3)" RELATED PSI-MS-label []
synonym: "Propionaldehyde +40" RELATED Unimod-description []
xref: DiffAvg: "40.06"
xref: DiffFormula: "C 3 H 4"
xref: DiffMono: "40.031300"
xref: Formula: "C 9 H 11 N 3 O 1"
xref: MassAvg: "177.21"
xref: MassMono: "177.090212"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:256"
is_obsolete: true

[Term]
id: MOD:01324
name: acetaldehyde +26 - site H
def: "OBSOLETE because this is not supported by the linked literature [PMT]" [PubMed:7744761, Unimod:254#H]
synonym: "Acetaldehyde +26" RELATED Unimod-description []
synonym: "Delta:H(2)C(2)" RELATED PSI-MS-label []
xref: DiffAvg: "26.04"
xref: DiffFormula: "C 2 H 2"
xref: DiffMono: "26.015650"
xref: Formula: "C 8 H 9 N 3 O 1"
xref: MassAvg: "163.18"
xref: MassMono: "163.074562"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:254"
is_obsolete: true

[Term]
id: MOD:01325
name: acetaldehyde +26 - site K
def: "OBSOLETE because this is not supported by the linked literature [PMT]" [PubMed:7744761, Unimod:254#K]
synonym: "Acetaldehyde +26" RELATED Unimod-description []
synonym: "Delta:H(2)C(2)" RELATED PSI-MS-label []
xref: DiffAvg: "26.04"
xref: DiffFormula: "C 2 H 2"
xref: DiffMono: "26.015650"
xref: Formula: "C 8 H 14 N 2 O 1"
xref: MassAvg: "154.21"
xref: MassMono: "154.110613"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:254"
is_obsolete: true

[Term]
id: MOD:01326
name: 9x(13)C labeled L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-tyrosine." [PubMed:11510821, PubMed:12422359, PubMed:12716131, Unimod:184#Y]
synonym: "13C(9) Silac label" RELATED Unimod-description []
synonym: "Label:13C(9)" RELATED PSI-MS-label []
xref: DiffAvg: "9.03"
xref: DiffFormula: "(12)C -9 (13)C 9"
xref: DiffMono: "9.030194"
xref: Formula: "(13)C 9 H 9 N 1 O 2"
xref: MassAvg: "172.09"
xref: MassMono: "172.093522"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:184"
is_a: MOD:00540 ! 9x(13)C labeled residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:01327
name: 9x(13)C labeled L-phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to 9x(13)C labeled L-phenylalanine." [PubMed:12716131, Unimod:184#F]
synonym: "13C(9) Silac label" RELATED Unimod-description []
synonym: "Label:13C(9)" RELATED PSI-MS-label []
xref: DiffAvg: "9.03"
xref: DiffFormula: "(12)C -9 (13)C 9"
xref: DiffMono: "9.030194"
xref: Formula: "(13)C 9 H 9 N 1 O 1"
xref: MassAvg: "156.10"
xref: MassMono: "156.098607"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:184"
is_a: MOD:00540 ! 9x(13)C labeled residue
is_a: MOD:00914 ! modified L-phenylalanine residue

[Term]
id: MOD:01328
name: iodoacetic acid - site W
def: "modification from Unimod Chemical derivative - hydroxylethanone" [PubMed:17525468, Unimod:6#W]
comment: There is no citation for this Unimod entry. Iodoacetic acid derivatization of tryptophan is not mentioned in the citation [JSG].
synonym: "Carboxymethyl" RELATED PSI-MS-label []
synonym: "Iodoacetic acid derivative" RELATED Unimod-description []
xref: DiffAvg: "58.04"
xref: DiffFormula: "C 2 H 2 O 2"
xref: DiffMono: "58.005479"
xref: Formula: "C 13 H 12 N 2 O 3"
xref: MassAvg: "244.25"
xref: MassMono: "244.084792"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:6"
is_a: MOD:00399 ! iodoacetic acid derivatized residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:01329
name: iodoacetic acid - site C
def: "OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061" [DeltaMass:197]
comment: Modification from Unimod Chemical derivative, Unimod:6 site C
synonym: "Carboxymethyl" RELATED PSI-MS-label []
synonym: "Iodoacetic acid derivative" RELATED Unimod-description []
xref: DiffAvg: "58.04"
xref: DiffFormula: "C 2 H 2 O 2"
xref: DiffMono: "58.005479"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:01061"
xref: Unimod: "Unimod:6"
is_obsolete: true

[Term]
id: MOD:01330
name: iodoacetic acid -site K
def: "OBSOLETE because identical with MOD:01094. Remap to MOD:01094" [PubMed:18688235]
comment: a modification from Unimod:6
synonym: "Carboxymethyl" RELATED PSI-MS-label []
synonym: "Iodoacetic acid derivative" RELATED Unimod-description []
xref: DiffAvg: "58.04"
xref: DiffFormula: "C 2 H 2 O 2"
xref: DiffMono: "58.005479"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:01094"
xref: Unimod: "Unimod:6"
is_obsolete: true

[Term]
id: MOD:01331
name: 6x(13)C labeled L-arginine
def: "A protein modification that effectively converts an L-arginine residue to 6x(13)C labeled L-arginine." [OMSSA:136, PubMed:12716131, Unimod:188#R]
subset: PSI-MOD-slim
synonym: "13C(6) Silac label" RELATED Unimod-description []
synonym: "arg-13c6" EXACT OMSSA-label []
synonym: "Label:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "6.02"
xref: DiffFormula: "(12)C -6 (13)C 6"
xref: DiffMono: "6.020129"
xref: Formula: "(13)C 6 H 12 N 4 O 1"
xref: MassAvg: "162.12"
xref: MassMono: "162.121240"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:188"
is_a: MOD:00544 ! 6x(13)C labeled residue

[Term]
id: MOD:01332
name: 6x(13)C labeled L-leucine
def: "A protein modification that effectively converts an L-leucine residue to 6x(13)C labeled L-leucine." [PubMed:12716131, Unimod:188#L]
subset: PSI-MOD-slim
synonym: "13C(6) Silac label" RELATED Unimod-description []
synonym: "Label:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "6.02"
xref: DiffFormula: "(12)C -6 (13)C 6"
xref: DiffMono: "6.020129"
xref: Formula: "(13)C 6 H 11 N 1 O 1"
xref: MassAvg: "119.10"
xref: MassMono: "119.104193"
xref: Origin: "L"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:188"
is_a: MOD:00544 ! 6x(13)C labeled residue

[Term]
id: MOD:01333
name: 6x(13)C labeled L-isoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to 6x(13)C labeled L-isoleucine." [PubMed:12716131, PubMed:12766232, Unimod:188#I]
subset: PSI-MOD-slim
synonym: "13C(6) Silac label" RELATED Unimod-description []
synonym: "Label:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "6.02"
xref: DiffFormula: "(12)C -6 (13)C 6"
xref: DiffMono: "6.020129"
xref: Formula: "(13)C 6 H 11 N 1 O 1"
xref: MassAvg: "119.10"
xref: MassMono: "119.104193"
xref: Origin: "I"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:188"
is_a: MOD:00544 ! 6x(13)C labeled residue

[Term]
id: MOD:01334
name: 6x(13)C labeled L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 6x(13)C labeled L-lysine." [OMSSA:138, PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:12716131, Unimod:188#K]
subset: PSI-MOD-slim
synonym: "13C(6) Silac label" RELATED Unimod-description []
synonym: "Label:13C(6)" RELATED PSI-MS-label []
synonym: "lys-13c6" EXACT OMSSA-label []
xref: DiffAvg: "6.02"
xref: DiffFormula: "(12)C -6 (13)C 6"
xref: DiffMono: "6.020129"
xref: Formula: "(13)C 6 H 12 N 2 O 1"
xref: MassAvg: "134.12"
xref: MassMono: "134.115092"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:188"
is_a: MOD:00544 ! 6x(13)C labeled residue

[Term]
id: MOD:01335
name: 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized lysine
def: "modification from Unimod Chemical derivative -" [PubMed:11467524, PubMed:16526082, Unimod:464#K]
synonym: "4-sulfophenyl isothiocyanate (Heavy C13)" RELATED Unimod-description []
synonym: "SPITC:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "220.99"
xref: DiffFormula: "(12)C 1 (13)C 6 H 5 N 1 O 3 S 2"
xref: DiffMono: "220.991214"
xref: Formula: "(12)C 7 (13)C 6 H 17 N 3 O 4 S 2"
xref: MassAvg: "349.09"
xref: MassMono: "349.086177"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:464"
is_a: MOD:00880 ! 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01336
name: deamidation followed by a methylation -site Q
def: "OBSOLETE - identical and redundant with MOD:00657. Remap to MOD:00657." [PubMed:18688235]
comment: Modification from Unimod Post-translational - Unimod:528.
synonym: "Deamidation followed by a methylation" RELATED Unimod-description []
synonym: "Methyl+Deamidated" RELATED PSI-MS-label []
xref: DiffAvg: "15.01"
xref: DiffFormula: "C 1 H 1 N -1 O 1"
xref: DiffMono: "14.999666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:00657"
xref: Unimod: "Unimod:528"
is_obsolete: true

[Term]
id: MOD:01337
name: deamidated 4-methyl esterified asparagine
def: "A protein modification that effectively converts an L-asparagine residue to L-aspartate 4-methyl ester." [Unimod:528#N]
comment: The deamidation and methylation of L-asparagine has not been reported as a natural modification. It is extremely unlikely that eukaryotes produce this modification, because a natural process that would form L-aspartic acid 4-methyl ester from either L-aspartic acid or L-asparagine would interfere with the D-aspartyl peptide repair mechanism [JSG].
synonym: "Deamidation followed by a methylation" RELATED Unimod-description []
synonym: "Methyl+Deamidated" RELATED PSI-MS-label []
xref: DiffAvg: "15.01"
xref: DiffFormula: "C 1 H 1 N -1 O 1"
xref: DiffMono: "14.999666"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "N"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:528"
relationship: derives_from MOD:01181 ! L-aspartic acid 4-methyl ester
is_a: MOD:01369 ! deamidated and methyl esterified residue

[Term]
id: MOD:01338
name: N6-ethyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-ethyl-L-lysine." [PubMed:9629898, Unimod:280#K]
comment: The Unimod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG].
synonym: "Ethyl" RELATED PSI-MS-label []
synonym: "Ethylation" RELATED Unimod-description []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4"
xref: DiffMono: "28.031300"
xref: Formula: "C 8 H 16 N 2 O 1"
xref: MassAvg: "156.23"
xref: MassMono: "156.126263"
xref: Origin: "K"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:280"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01339 ! ethylated residue

[Term]
id: MOD:01339
name: ethylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an ethyl group." [PubMed:9629898, Unimod:280]
comment: From DeltaMass: Average Mass: 28 with no citation. The Unimod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG].
synonym: "Ethyl" RELATED PSI-MS-label []
synonym: "Ethylation" RELATED Unimod-description []
synonym: "EtRes" EXACT PSI-MOD-label []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4"
xref: DiffMono: "28.031300"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:280"
is_a: MOD:00001 ! alkylated residue

[Term]
id: MOD:01340
name: ESP-Tag heavy d10 - site K
def: "modification from Unimod Isotopic label -" [PubMed:11078590, PubMed:11085420, PubMed:11821862, Unimod:91#K]
synonym: "ESP-Tag heavy d10" RELATED Unimod-description []
synonym: "ESP:2H(10)" RELATED PSI-MS-label []
xref: DiffAvg: "348.24"
xref: DiffFormula: "C 16 (1)H 16 (2)H 10 N 4 O 2 S 1"
xref: DiffMono: "348.240415"
xref: Formula: "C 22 (1)H 28 (2)H 10 N 6 O 3 S 1"
xref: MassAvg: "476.34"
xref: MassMono: "476.335378"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:91"
is_a: MOD:00469 ! ESP-Tag heavy d10
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01341
name: ESP-Tag light d0 - site K
def: "modification from Unimod Isotopic label -" [Unimod:90#K]
synonym: "ESP" RELATED PSI-MS-label []
synonym: "ESP-Tag light d0" RELATED Unimod-description []
xref: DiffAvg: "338.47"
xref: DiffFormula: "C 16 H 26 N 4 O 2 S 1"
xref: DiffMono: "338.177647"
xref: Formula: "C 22 H 38 N 6 O 3 S 1"
xref: MassAvg: "466.64"
xref: MassMono: "466.272610"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:90"
is_a: MOD:00468 ! ESP-Tag light d0
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01342
name: selenium substitution for sulfur - site M
def: "OBSOLETE because redundant and identical to MOD:00530. Remap to MOD:00530." [PubMed:12148805, Unimod:162]
synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label []
synonym: "Selenium replaces sulphur" RELATED Unimod-description []
xref: DiffAvg: "46.91"
xref: DiffFormula: "S -1 Se 1"
xref: DiffMono: "47.944450"
xref: Formula: "C 5 H 9 N 1 O 1 S 0 Se 1"
xref: MassAvg: "178.10"
xref: MassMono: "178.984935"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00530"
xref: Unimod: "Unimod:162"
is_obsolete: true

[Term]
id: MOD:01343
name: selenium substitution for sulfur - site C
def: "OBSOLETE because redundant and identical to MOD:00686. Remap to MOD:00686." [PubMed:12148805, Unimod:162]
synonym: "Delta:S(-1)Se(1)" RELATED PSI-MS-label []
synonym: "Selenium replaces sulphur" RELATED Unimod-description []
xref: DiffAvg: "46.91"
xref: DiffFormula: "S -1 Se 1"
xref: DiffMono: "47.944450"
xref: Formula: "C 3 H 5 N 1 O 1 S 0 Se 1"
xref: MassAvg: "150.05"
xref: MassMono: "150.953635"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00686"
xref: Unimod: "Unimod:162"
is_obsolete: true

[Term]
id: MOD:01344
name: dehydrogenated residue - site S
def: "OBSOLETE because redundant and identical with MOD:00835. Remap to MOD:00835." [PubMed:9252331, PubMed:9276974, Unimod:401]
synonym: "2-amino-3-oxo-butanoic_acid" RELATED Unimod-description []
synonym: "Didehydro" RELATED PSI-MS-label []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "H -2"
xref: DiffMono: "-2.015650"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:00835"
xref: Unimod: "Unimod:401"
is_obsolete: true

[Term]
id: MOD:01345
name: 2-amino-3-oxobutanoic acid
def: "A protein modification that effectively converts an L-threonine residue to 2-amino-3-oxobutanoic acid." [OMSSA:23, PubMed:12716131, PubMed:9252331, Unimod:401#T]
comment: There is no citation for this modification in the Unimod entry. Although mentioned in PubMed:9252331, there is no citation for it there [JSG].
synonym: "2-amino-3-ketobutyric acid" EXACT PSI-MOD-alternate []
synonym: "2-amino-3-oxo-butanoic_acid" RELATED Unimod-description []
synonym: "3-ketobutyrine" EXACT PSI-MOD-alternate []
synonym: "Didehydro" RELATED PSI-MS-label []
synonym: "twoamino3oxobutanoicacid" EXACT OMSSA-label []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "H -2"
xref: DiffMono: "-2.015650"
xref: Formula: "C 4 H 5 N 1 O 2"
xref: MassAvg: "99.09"
xref: MassMono: "99.032028"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:401"
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:01888 ! didehydrogenated residue

[Term]
id: MOD:01346
name: N4-hexosylated asparagine
def: "A protein modification that effectively converts an L-asparagine residue to an N4-hexosyl-L-asparagine." [PubMed:11112526, PubMed:11567090, PubMed:15279557, PubMed:6540775, Unimod:41#N]
synonym: "Hex" RELATED PSI-MS-label []
synonym: "Hexose" RELATED Unimod-description []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 10 H 16 N 2 O 7"
xref: MassAvg: "276.25"
xref: MassMono: "276.095751"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:41"
is_a: MOD:00160 ! N4-glycosyl-L-asparagine
is_a: MOD:00434 ! hexosylated residue

[Term]
id: MOD:01347
name: hexose glycated L-lysine
def: "A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and an L-lysine residue to form a Schiff-base or an Amadori ketosamine lysine adduct." [DeltaMass:0, PubMed:15279557, Unimod:41#K]
synonym: "Hex" RELATED PSI-MS-label []
synonym: "Hexose" RELATED Unimod-description []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 12 H 22 N 2 O 6"
xref: MassAvg: "290.32"
xref: MassMono: "290.147786"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:41"
is_a: MOD:00767 ! glycated residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01348
name: O-hexosylated threonine
def: "A protein modification that effectively converts an L-threonine residue to an O-hexosyl-L-threonine." [PubMed:15279557, PubMed:8597590, Unimod:41#T]
synonym: "Hex" RELATED PSI-MS-label []
synonym: "Hexose" RELATED Unimod-description []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 10 H 17 N 1 O 7"
xref: MassAvg: "263.25"
xref: MassMono: "263.100502"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:41"
is_a: MOD:00005 ! O-glycosyl-L-threonine
is_a: MOD:00434 ! hexosylated residue

[Term]
id: MOD:01349
name: hydrolyzed N-ethylmaleimide cysteine adduct
def: "modification from Unimod Chemical derivative -" [Unimod:320#C]
comment: Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(S-cysteinyl)-4-(ethylamino)-4-oxobutanoic acid [JSG].
synonym: "Nethylmaleimide+water" RELATED PSI-MS-label []
synonym: "Nethylmaleimidehydrolysis" RELATED Unimod-description []
xref: DiffAvg: "143.14"
xref: DiffFormula: "C 6 H 9 N 1 O 3"
xref: DiffMono: "143.058243"
xref: Formula: "C 9 H 14 N 2 O 4 S 1"
xref: MassAvg: "246.28"
xref: MassMono: "246.067428"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:320"
is_a: MOD:00631 ! hydrolyzed N-ethylmaleimide adduct
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01350
name: hydrolyzed N-ethylmaleimide lysine adduct
def: "modification from Unimod Chemical derivative -" [Unimod:320#K]
comment: Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(N6-lysyl)-4-(ethylamino)-4-oxobutanoic acid [JSG].
synonym: "Nethylmaleimide+water" RELATED PSI-MS-label []
synonym: "Nethylmaleimidehydrolysis" RELATED Unimod-description []
xref: DiffAvg: "143.14"
xref: DiffFormula: "C 6 H 9 N 1 O 3"
xref: DiffMono: "143.058243"
xref: Formula: "C 12 H 21 N 3 O 4"
xref: MassAvg: "271.32"
xref: MassMono: "271.153206"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:320"
is_a: MOD:00631 ! hydrolyzed N-ethylmaleimide adduct

[Term]
id: MOD:01351
name: nitrated L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to a nitrated L-tryptophan." [OMSSA:85, PubMed:8839040, PubMed:9252331, Unimod:354#W]
comment: One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG].
synonym: "Nitro" RELATED PSI-MS-label []
synonym: "nitrow" EXACT OMSSA-label []
synonym: "Oxidation to nitro" RELATED Unimod-description []
xref: DiffAvg: "45.00"
xref: DiffFormula: "H -1 N 1 O 2"
xref: DiffMono: "44.985078"
xref: Formula: "C 11 H 9 N 3 O 3"
xref: MassAvg: "231.21"
xref: MassMono: "231.064391"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:354"
is_a: MOD:00461 ! nitrated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:01352
name: nitrated L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to a nitrated L-tyrosine." [OMSSA:86, PubMed:14678012, PubMed:8839040, PubMed:9252331, Unimod:354#Y]
comment: One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG].
subset: PSI-MOD-slim
synonym: "Nitro" RELATED PSI-MS-label []
synonym: "nitroy" EXACT OMSSA-label []
synonym: "Oxidation to nitro" RELATED Unimod-description []
xref: DiffAvg: "45.00"
xref: DiffFormula: "H -1 N 1 O 2"
xref: DiffMono: "44.985078"
xref: Formula: "C 9 H 8 N 2 O 4"
xref: MassAvg: "208.17"
xref: MassMono: "208.048407"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:354"
xref: uniprot.ptm:PTM-0213
is_a: MOD:00461 ! nitrated residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:01353
name: amidination of lysines or N-terminal amines with methyl acetimidate - site K
def: "modification from Unimod Chemical derivative -" [PubMed:12643539, PubMed:15602776, PubMed:6273432, Unimod:141#K]
synonym: "amidination of lysines or N-terminal amines with methyl acetimidate" RELATED Unimod-description []
synonym: "Amidine" RELATED PSI-MS-label []
xref: DiffAvg: "41.05"
xref: DiffFormula: "C 2 H 3 N 1"
xref: DiffMono: "41.026549"
xref: Formula: "C 8 H 15 N 3 O 1"
xref: MassAvg: "169.23"
xref: MassMono: "169.121512"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:141"
is_a: MOD:00509 ! amidination of lysines or N-terminal amines with methyl acetimidate
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01354
name: Hex1HexNAc1NeuAc1 N4-glycosylated asparagine
def: "A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [PubMed:11698400, Unimod:149#N]
synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc1NeuAc1" RELATED Unimod-description []
xref: DiffAvg: "657.60"
xref: DiffFormula: "C 25 H 41 N 2 O 18"
xref: DiffMono: "657.235437"
xref: Formula: "C 29 H 47 N 4 O 20"
xref: MassAvg: "771.70"
xref: MassMono: "771.278365"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:149"
is_a: MOD:00517 ! Hex1HexNAc1NeuAc1 glycosylated residue
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:01355
name: Hex1HexNAc1NeuAc1 O-glycosylated threonine
def: "A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [Unimod:149#T]
synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc1NeuAc1" RELATED Unimod-description []
xref: DiffAvg: "657.60"
xref: DiffFormula: "C 25 H 41 N 2 O 18"
xref: DiffMono: "657.235437"
xref: Formula: "C 29 H 48 N 3 O 20"
xref: MassAvg: "758.70"
xref: MassMono: "758.283116"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:149"
is_a: MOD:00517 ! Hex1HexNAc1NeuAc1 glycosylated residue
is_a: MOD:00005 ! O-glycosyl-L-threonine

[Term]
id: MOD:01356
name: Hex1HexNAc1NeuAc1 O-glycosylated serine
def: "A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond." [PubMed:7856876, Unimod:149#S]
synonym: "Hex(1)HexNAc(1)NeuAc(1)" RELATED PSI-MS-label []
synonym: "Hex1HexNAc1NeuAc1" RELATED Unimod-description []
xref: DiffAvg: "657.60"
xref: DiffFormula: "C 25 H 41 N 2 O 18"
xref: DiffMono: "657.235437"
xref: Formula: "C 28 H 46 N 3 O 20"
xref: MassAvg: "744.68"
xref: MassMono: "744.267466"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:149"
is_a: MOD:00517 ! Hex1HexNAc1NeuAc1 glycosylated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01357
name: 2x(13)C,4x(2)H labeled dimethylated L-lysine
def: "A protein modification that effectively replaces two hydrogen atoms of an L-lysine residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-lysine." [PubMed:12686488, PubMed:16335955, Unimod:510#K]
synonym: "DiMethyl-C13HD2" RELATED Unimod-description []
synonym: "Dimethyl:2H(4)13C(2)" RELATED PSI-MS-label []
xref: DiffAvg: "34.06"
xref: DiffFormula: "(13)C 2 (2)H 4"
xref: DiffMono: "34.063117"
xref: Formula: "(12)C 6 (13)C 2 (1)H 12 (2)H 4 N 2 O 1"
xref: MassAvg: "162.16"
xref: MassMono: "162.158080"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:510"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:00927 ! 2x(13)C,4x(2)H labeled dimethylated residue
relationship: derives_from MOD:00084 ! N6,N6-dimethyl-L-lysine

[Term]
id: MOD:01358
name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site N-term
def: "modification from Unimod Isotopic label - Use when labelling post-digest" [PubMed:15602776, Unimod:687#N-term]
synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form" RELATED Unimod-description []
synonym: "ICPL:2H(4)" RELATED PSI-MS-label []
xref: DiffAvg: "109.05"
xref: DiffFormula: "C 6 (1)H -1 (2)H 4 N 1 O 1"
xref: DiffMono: "109.046571"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:687"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:01359
name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form - site K
def: "modification from Unimod Isotopic label - Use when labelling post-digest" [PubMed:15602776, Unimod:687#K]
synonym: "Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, medium form" RELATED Unimod-description []
synonym: "ICPL:2H(4)" RELATED PSI-MS-label []
xref: DiffAvg: "109.05"
xref: DiffFormula: "C 6 (1)H -1 (2)H 4 N 1 O 1"
xref: DiffMono: "109.046571"
xref: Formula: "C 12 (1)H 11 (2)H 4 N 3 O 2"
xref: MassAvg: "237.14"
xref: MassMono: "237.141534"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:687"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:01360
name: 4-sulfophenyl isothiocyanate N6-derivatized lysine
def: "A protein modification that effectively converts an L-lysine residue to the 4-sulfophenyl isothiocyanate adduct, N6-[(4-sulfophenyl)carbamothioyl]lysine." [PubMed:14689565, PubMed:14745769, PubMed:15549660, PubMed:16526082, Unimod:261#K]
synonym: "4-sulfophenyl isothiocyanate" RELATED Unimod-description []
synonym: "N6-[(4-sulfophenyl)carbamothioyl]lysine" EXACT PSI-MOD-alternate []
synonym: "SPITC" RELATED PSI-MS-label []
xref: DiffAvg: "215.24"
xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2"
xref: DiffMono: "214.971085"
xref: Formula: "C 13 H 17 N 3 O 4 S 2"
xref: MassAvg: "343.42"
xref: MassMono: "343.066048"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:261"
is_a: MOD:00584 ! 4-sulfophenyl isothiocyanate derivatized residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01361
name: O-thiophospho-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-thiophospho-L-threonine." [PubMed:11507762, PubMed:12110917, Unimod:260#T]
synonym: "Thiophospho" RELATED PSI-MS-label []
synonym: "Thiophosphorylation" RELATED Unimod-description []
xref: DiffAvg: "96.04"
xref: DiffFormula: "H 1 O 2 P 1 S 1"
xref: DiffMono: "95.943487"
xref: Formula: "C 4 H 8 N 1 O 4 P 1 S 1"
xref: MassAvg: "197.14"
xref: MassMono: "196.991165"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:260"
is_a: MOD:00583 ! thiophosphorylated residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01362
name: O-thiophospho-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-thiophospho-L-serine." [PubMed:11507762, PubMed:12110917, Unimod:260#S]
synonym: "Thiophospho" RELATED PSI-MS-label []
synonym: "Thiophosphorylation" RELATED Unimod-description []
xref: DiffAvg: "96.04"
xref: DiffFormula: "H 1 O 2 P 1 S 1"
xref: DiffMono: "95.943487"
xref: Formula: "C 3 H 6 N 1 O 4 P 1 S 1"
xref: MassAvg: "183.12"
xref: MassMono: "182.975515"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:260"
is_a: MOD:00583 ! thiophosphorylated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01363
name: O4'-thiophospho-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to O4'-thiophospho-L-tyrosine." [PubMed:12110917, PubMed:15549660, Unimod:260#Y]
synonym: "Thiophospho" RELATED PSI-MS-label []
synonym: "Thiophosphorylation" RELATED Unimod-description []
xref: DiffAvg: "96.04"
xref: DiffFormula: "H 1 O 2 P 1 S 1"
xref: DiffMono: "95.943487"
xref: Formula: "C 9 H 10 N 1 O 4 P 1 S 1"
xref: MassAvg: "259.22"
xref: MassMono: "259.006815"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:260"
is_a: MOD:00583 ! thiophosphorylated residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:01364
name: fluorescein-5-thiosemicarbazide - site S
def: "modification from Unimod Chemical derivative -" [PubMed:11467524, Unimod:478#S]
synonym: "fluorescein-5-thiosemicarbazide" RELATED Unimod-description []
synonym: "FTC" RELATED PSI-MS-label []
xref: DiffAvg: "421.43"
xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1"
xref: DiffMono: "421.073242"
xref: Formula: "C 24 H 20 N 4 O 7 S 1"
xref: MassAvg: "508.51"
xref: MassMono: "508.105270"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:478"
is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide modified residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01365
name: fluorescein-5-thiosemicarbazide - site C
def: "modification from Unimod Chemical derivative -" [Unimod:478#C]
synonym: "fluorescein-5-thiosemicarbazide" RELATED Unimod-description []
synonym: "FTC" RELATED PSI-MS-label []
xref: DiffAvg: "421.43"
xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1"
xref: DiffMono: "421.073242"
xref: Formula: "C 24 H 20 N 4 O 6 S 2"
xref: MassAvg: "524.57"
xref: MassMono: "524.082426"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:478"
is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01366
name: fluorescein-5-thiosemicarbazide - site K
def: "modification from Unimod Chemical derivative -" [Unimod:478#K]
synonym: "fluorescein-5-thiosemicarbazide" RELATED Unimod-description []
synonym: "FTC" RELATED PSI-MS-label []
xref: DiffAvg: "421.43"
xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1"
xref: DiffMono: "421.073242"
xref: Formula: "C 27 H 27 N 5 O 6 S 1"
xref: MassAvg: "549.60"
xref: MassMono: "549.168205"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:478"
is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide modified residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01367
name: fluorescein-5-thiosemicarbazide - site P
def: "modification from Unimod Chemical derivative -" [Unimod:478#P]
synonym: "fluorescein-5-thiosemicarbazide" RELATED Unimod-description []
synonym: "FTC" RELATED PSI-MS-label []
xref: DiffAvg: "421.43"
xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1"
xref: DiffMono: "421.073242"
xref: Formula: "C 26 H 22 N 4 O 6 S 1"
xref: MassAvg: "518.54"
xref: MassMono: "518.126005"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:478"
is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide modified residue
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:01368
name: fluorescein-5-thiosemicarbazide - site R
def: "modification from Unimod Chemical derivative -" [PubMed:15525938, Unimod:478#R]
synonym: "fluorescein-5-thiosemicarbazide" RELATED Unimod-description []
synonym: "FTC" RELATED PSI-MS-label []
xref: DiffAvg: "421.43"
xref: DiffFormula: "C 21 H 15 N 3 O 5 S 1"
xref: DiffMono: "421.073242"
xref: Formula: "C 27 H 27 N 7 O 6 S 1"
xref: MassAvg: "577.62"
xref: MassMono: "577.174353"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:478"
is_a: MOD:00626 ! fluorescein-5-thiosemicarbazide modified residue
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:01369
name: deamidated and methyl esterified residue
def: "A protein modification that effectively replaces a carboxamido group with a carboxyl methyl ester group." [Unimod:528]
subset: PSI-MOD-slim
synonym: "Deamidation followed by a methylation" RELATED Unimod-description []
synonym: "Methyl+Deamidated" RELATED PSI-MS-label []
xref: DiffAvg: "15.01"
xref: DiffFormula: "C 1 H 1 N -1 O 1"
xref: DiffMono: "14.999666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:528"
is_a: MOD:00393 ! O-methylated residue
relationship: contains MOD:00400 ! deamidated residue

[Term]
id: MOD:01370
name: 6x(13)C,1x(15)N labeled residue
def: "A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C,1x(15)N labeled residue." [PubMed:11857757, PubMed:11999733, PubMed:12175151, Unimod:695]
synonym: "13C(6) 15N(1) Silac label" RELATED Unimod-description []
synonym: "Label:13C(6)15N(1)" RELATED PSI-MS-label []
xref: DiffAvg: "7.02"
xref: DiffFormula: "(12)C -6 (13)C 6 (14)N -1 (15)N 1"
xref: DiffMono: "7.017164"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:695"
is_a: MOD:00842 ! (13)C labeled residue
is_a: MOD:00843 ! (15)N labeled residue

[Term]
id: MOD:01371
name: deamidation in presence of O18
def: "OBSOLETE bcecause identical and redundant with MOD:00851. Remap to MOD:00851." [PubMed:8382902]
synonym: "Deamidated:18O(1)" RELATED PSI-MS-label []
synonym: "Deamidation in presence of O18" RELATED Unimod-description []
xref: DiffAvg: "2.99"
xref: DiffFormula: "H -1 N -1 (18)O 1"
xref: DiffMono: "2.988262"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00851"
is_obsolete: true

[Term]
id: MOD:01372
name: (2S)-4-hydroxyleucine
def: "A protein modification that effectively converts an L-leucine residue to a (2S)-4-hydroxyleucine." [PubMed:363352, PubMed:9164839, RESID:AA0442, ChEBI:141825]
synonym: "(2S)-2-amino-4-hydroxy-4-methylpentanoic acid" EXACT RESID-systematic []
synonym: "(2S)-4-hydroxyleucine" EXACT RESID-name []
synonym: "gamma-hydroxyleucine" EXACT RESID-alternate []
synonym: "MOD_RES (2S)-4-hydroxyleucine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 11 N 1 O 2"
xref: MassAvg: "129.16"
xref: MassMono: "129.078979"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0665
is_a: MOD:01411 ! monohydroxylated leucine

[Term]
id: MOD:01373
name: (2S,4R)-5-hydroxyleucine
def: "A protein modification that effectively converts an L-leucine residue to a (2S,4R)-5-hydroxyleucine." [PubMed:16858410, PubMed:7690768, PubMed:9164839, RESID:AA0443, ChEBI:141824]
synonym: "(2S,4R)-2-amino-5-hydroxy-4-methylpentanoic acid" EXACT RESID-systematic []
synonym: "(2S,4R)-5-hydroxyleucine" EXACT RESID-name []
synonym: "(4R)-5-hydroxyleucine" EXACT RESID-alternate []
synonym: "delta-hydroxyleucine" EXACT RESID-alternate []
synonym: "MOD_RES (4R)-5-hydroxyleucine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 11 N 1 O 2"
xref: MassAvg: "129.16"
xref: MassMono: "129.078979"
xref: Origin: "L"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0491
is_a: MOD:01411 ! monohydroxylated leucine

[Term]
id: MOD:01374
name: (2S,4R)-5-oxoleucine
def: "A modification that effectively oxygenates C5 of an L-leucine residue to form a (2S,4R)-5-oxoleucine." [ChEBI:43739, PubMed:16858410, RESID:AA0444]
synonym: "(2S,4R)-2-amino-4-methyl-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "(2S,4R)-5-oxoleucine" EXACT RESID-name []
synonym: "(4R)-5-oxo-L-leucine" EXACT RESID-alternate []
xref: DiffAvg: "13.98"
xref: DiffFormula: "C 0 H -2 N 0 O 1"
xref: DiffMono: "13.979265"
xref: Formula: "C 6 H 9 N 1 O 2"
xref: MassAvg: "127.14"
xref: MassMono: "127.063329"
xref: Origin: "L"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0492
is_a: MOD:00679 ! carbon oxygenated residue
is_a: MOD:00911 ! modified L-leucine residue

[Term]
id: MOD:01375
name: (2S,4R)-4,5-dihydroxyleucine
def: "A protein modification that effectively converts an L-leucine residue to a (2S,4R)-4,5-dihydroxyleucine." [PubMed:6010785, PubMed:6893271, RESID:AA0445, ChEBI:141823]
synonym: "(2S,4R)-2-amino-4,5-dihydroxy-4-methylpentanoic acid" EXACT RESID-systematic []
synonym: "(2S,4R)-4,5-dihydroxyleucine" EXACT RESID-name []
synonym: "(4R)-4,5-dihydroxyleucine" EXACT RESID-alternate []
synonym: "gamma,delta-dihydroxyleucine" EXACT RESID-alternate []
synonym: "MOD_RES (4R)-4,5-dihydroxyleucine" EXACT UniProt-feature []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 6 H 11 N 1 O 3"
xref: MassAvg: "145.16"
xref: MassMono: "145.073893"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0340
is_a: MOD:01412 ! dihydroxylated leucine

[Term]
id: MOD:01376
name: (2S,3S,4R)-3,4-dihydroxyisoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to a (2S,3S,4R)-3,4-dihydroxyisoleucine." [PubMed:11320328, RESID:AA0447, ChEBI:141827]
synonym: "(2S,3S,4R)-2-amino-3,4-dihydroxy-3-methylpentanoic acid" EXACT RESID-systematic []
synonym: "(2S,3S,4R)-3,4-dihydroxyisoleucine" EXACT RESID-name []
synonym: "(3S,4R)-3,4-dihydroxyisoleucine" EXACT RESID-alternate []
synonym: "beta,gamma-dihydroxyisoleucine" EXACT RESID-alternate []
synonym: "MOD_RES (3S,4R)-3,4-dihydroxyisoleucine" EXACT UniProt-feature []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 6 H 11 N 1 O 3"
xref: MassAvg: "145.16"
xref: MassMono: "145.073893"
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0343
is_a: MOD:01416 ! dihydroxylated isoleucine

[Term]
id: MOD:01377
name: (2S,3R,4S)-4-hydroxyisoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4S)-4-hydroxyisoleucine." [PubMed:363352, RESID:AA0448, ChEBI:141844]
synonym: "(2S,3R,4S)-2-amino-3-methyl-4-hydroxyvaleric acid" EXACT RESID-alternate []
synonym: "(2S,3R,4S)-2-amino-4-hydroxy-3-methylpentanoic acid" EXACT RESID-systematic []
synonym: "(2S,3R,4S)-4-hydroxyisoleucine" EXACT RESID-name []
synonym: "(3R,4S)-4-hydroxyisoleucine" EXACT RESID-alternate []
synonym: "gamma-hydroxyisoleucine" EXACT RESID-alternate []
synonym: "MOD_RES (3R,4S)-4-hydroxyisoleucine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 11 N 1 O 2"
xref: MassAvg: "129.16"
xref: MassMono: "129.078979"
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0337
is_a: MOD:01415 ! monohydroxylated isoleucine

[Term]
id: MOD:01378
name: (2S,3R,4R)-4,5-dihydroxyisoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4R)-4,5-dihydroxyisoleucine." [PubMed:11805306, PubMed:18552824, PubMed:363352, RESID:AA0449, ChEBI:141826]
synonym: "(2S,3R,4R)-2-amino-4,5-dihydroxy-3-methylpentanoic acid" EXACT RESID-systematic []
synonym: "(2S,3R,4R)-4,5-dihydroxyisoleucine" EXACT RESID-name []
synonym: "(3R,4R)-4,5-dihydroxyisoleucine" EXACT RESID-alternate []
synonym: "gamma,delta-dihydroxyisoleucine" EXACT RESID-alternate []
synonym: "MOD_RES (3R,4R)-4,5-dihydroxyisoleucine" EXACT UniProt-feature []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 6 H 11 N 1 O 3"
xref: MassAvg: "145.16"
xref: MassMono: "145.073893"
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0336
is_a: MOD:01416 ! dihydroxylated isoleucine

[Term]
id: MOD:01379
name: 2'-methylsulfonyl-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to 2'-methylsulfonyl-L-tryptophan." [PubMed:6893271, RESID:AA0450]
synonym: "2'-methylsulfonyl-L-tryptophan" EXACT RESID-name []
synonym: "2-methylsulfonyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole" EXACT RESID-systematic []
synonym: "MOD_RES 2'-methylsulfonyltryptophan" EXACT UniProt-feature []
xref: DiffAvg: "78.09"
xref: DiffFormula: "C 1 H 2 N 0 O 2 S 1"
xref: DiffMono: "77.977550"
xref: Formula: "C 12 H 12 N 2 O 3 S 1"
xref: MassAvg: "264.30"
xref: MassMono: "264.056863"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0304
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:01380
name: 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide." [PubMed:11805306, PubMed:18552824, PubMed:363352, PubMed:4865716, RESID:AA0451]
comment: Cross-link 2.
synonym: "2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide" EXACT RESID-name []
synonym: "2-((2R)-2-amino-2carboxyethyl)sulfinyl-3-((2S)-2-amino-2-carboxyethyl)-1H-indole" EXACT RESID-systematic []
synonym: "6'-hydroxy-S-oxo-tryptathionine" EXACT RESID-alternate []
synonym: "CROSSLNK 2'-cysteinyl-6'-hydroxytryptophan sulfoxide (Trp-Cys)" EXACT UniProt-feature []
xref: DiffAvg: "29.98"
xref: DiffFormula: "C 0 H -2 N 0 O 2 S 0"
xref: DiffMono: "29.974179"
xref: Formula: "C 14 H 13 N 3 O 4 S 1"
xref: MassAvg: "319.33"
xref: MassMono: "319.062677"
xref: Origin: "C, W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0338
is_a: MOD:00687 ! thioether crosslinked residues
is_a: MOD:02057 ! crosslinked L-tryptophan residue

[Term]
id: MOD:01381
name: O-palmitoleyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-palmitoleyl-L-serine." [OMSSA:186, PubMed:17141155, RESID:AA0455]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-((9Z)-9-hexadecenoyloxy)propanoic acid" EXACT RESID-systematic []
synonym: "L-serine cis-9-hexadecenoate ester" EXACT RESID-alternate []
synonym: "LIPID O-palmitoleyl serine" EXACT UniProt-feature []
synonym: "mod186" EXACT OMSSA-label []
synonym: "O-palmitoleyl-L-serine" EXACT RESID-name []
synonym: "O3-palmitoleyl-serine" EXACT RESID-alternate []
xref: DiffAvg: "236.40"
xref: DiffFormula: "C 16 H 28 N 0 O 1"
xref: DiffMono: "236.214016"
xref: Formula: "C 19 H 33 N 1 O 3"
xref: MassAvg: "323.48"
xref: MassMono: "323.246044"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0493
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01768 ! O-palmitoleylated residue

[Term]
id: MOD:01382
name: N,N,N-trimethyl-L-methionine
def: "A protein modification that effectively converts an L-methionine residue to N,N,N-trimethyl-L-methionine." [PubMed:18611379, RESID:AA0456]
subset: PSI-MOD-slim
synonym: "(1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanaminium" EXACT RESID-systematic []
synonym: "(1S)-1-carboxy-N,N,N-trimethyl-3-(methylsulfanyl)propanazanium" EXACT RESID-alternate []
synonym: "2-trimethylammonio-4-(methylthio)butanoic acid" EXACT RESID-alternate []
synonym: "MOD_RES N,N,N-trimethylmethionine" EXACT UniProt-feature []
synonym: "N,N,N-trimethyl-L-methionine" EXACT RESID-name []
synonym: "N,N,N-trimethylmethionine cation" EXACT RESID-alternate []
synonym: "N,N,N-trimethylmethioninium" EXACT RESID-alternate []
synonym: "N2Me3+Met" EXACT PSI-MOD-label []
xref: DiffAvg: "43.09"
xref: DiffFormula: "C 3 H 7 N 0 O 0 S 0"
xref: DiffMono: "43.054227"
xref: FormalCharge: "1+"
xref: Formula: "C 8 H 17 N 1 O 1 S 1"
xref: MassAvg: "175.29"
xref: MassMono: "175.102537"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0503
is_a: MOD:01463 ! N-methylated methionine
is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue

[Term]
id: MOD:01383
name: L-cystine S-oxide
def: "A protein modification that effectively cross-links two L-cysteine residues and oxidizes a sulfur to form L-cystine S-oxide." [RESID:AA0457]
comment: Cross-link 2.
synonym: "(2R)-2-amino-3-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)sulfinyl]propanoic acid" EXACT RESID-systematic []
synonym: "CROSSLNK S-cysteinyl 3-(oxidosulfanyl)alanine (Cys-Cys)" EXACT UniProt-feature []
synonym: "cystine sulfoxide" EXACT RESID-alternate []
synonym: "L-cystine S-oxide" EXACT RESID-name []
synonym: "S-[(2R)-2-amino-3-oxopropyl] (2R)-2-amino-3-oxopropane-1-sulfinothioate" EXACT RESID-alternate []
synonym: "S-cysteinyl 3-(oxidosulfanyl)alanine" EXACT RESID-alternate []
xref: DiffAvg: "13.98"
xref: DiffFormula: "C 0 H -2 N 0 O 1 S 0"
xref: DiffMono: "13.979265"
xref: Formula: "C 6 H 8 N 2 O 3 S 2"
xref: MassAvg: "220.26"
xref: MassMono: "219.997634"
xref: Origin: "C, C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0324
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:00689 ! disulfide crosslinked residues

[Term]
id: MOD:01384
name: aminomalonic acid (Ser)
def: "A protein modification that effectively converts an L-serine residue to an aminomalonic acid." [PubMed:1621954, PubMed:5415959, PubMed:6366787, PubMed:7457858, RESID:AA0458]
synonym: "2-carboxyglycine" EXACT RESID-alternate []
synonym: "Ama" EXACT RESID-alternate []
synonym: "aminomalonic acid" EXACT RESID-name []
synonym: "aminopropanedioic acid" EXACT RESID-systematic []
synonym: "MOD_RES Aminomalonic acid (Ser)" EXACT UniProt-feature []
xref: DiffAvg: "13.98"
xref: DiffFormula: "C 0 H -2 N 0 O 1 S 0"
xref: DiffMono: "13.979265"
xref: Formula: "C 3 H 3 N 1 O 3"
xref: MassAvg: "101.06"
xref: MassMono: "101.011293"
xref: Origin: "S"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0321
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01385
name: 3-hydroxy-L-phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to 3-hydroxy-L-phenylalanine." [ChEBI:16795, OMSSA:63, PubMed:10625477, PubMed:15651011, PubMed:16734421, PubMed:1880060, PubMed:7398618, PubMed:7844053, RESID:AA0462]
synonym: "(2S,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid" EXACT RESID-systematic []
synonym: "3-hydoxyphenylalanine" EXACT RESID-alternate []
synonym: "3-hydroxy-L-phenylalanine" EXACT RESID-name []
synonym: "3-phenyl-L-serine" EXACT RESID-alternate []
synonym: "3HyPhe" EXACT PSI-MOD-label []
synonym: "beta-hydroxyphenylalanine" EXACT RESID-alternate []
synonym: "beta-phenylserine" EXACT RESID-alternate []
synonym: "hydroxylationf" EXACT OMSSA-label []
synonym: "L-threo-3-phenylserine" EXACT RESID-alternate []
synonym: "MOD_RES 3-hydroxyphenylalanine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 9 H 9 N 1 O 2"
xref: MassAvg: "163.18"
xref: MassMono: "163.063329"
xref: Origin: "F"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0346
is_a: MOD:00677 ! hydroxylated residue
is_a: MOD:00914 ! modified L-phenylalanine residue

[Term]
id: MOD:01386
name: 3-hydroxy-L-valine
def: "A protein modification that effectively converts an L-valine residue to 3-hydroxy-L-valine." [PubMed:7328054, RESID:AA0463, ChEBI:141793]
synonym: "(2S)-2-amino-3-hydroxy-3-methylbutanoic acid" EXACT RESID-systematic []
synonym: "3-hydroxy-L-valine" EXACT RESID-name []
synonym: "3-hydroxyvaline" EXACT RESID-alternate []
synonym: "3HyVal" EXACT PSI-MOD-label []
synonym: "MOD_RES 3-hydroxyvaline" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 9 N 1 O 2"
xref: MassAvg: "115.13"
xref: MassMono: "115.063329"
xref: Origin: "V"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0347
is_a: MOD:00677 ! hydroxylated residue
is_a: MOD:00920 ! modified L-valine residue

[Term]
id: MOD:01387
name: O-methyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-methyl-L-threonine." [PubMed:7328054, RESID:AA0464]
synonym: "(2S,3R)-2-amino-3-methoxybutanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES O-methylthreonine" EXACT UniProt-feature []
synonym: "O-methyl threonine" EXACT RESID-alternate []
synonym: "O-methyl-L-threonine" EXACT RESID-name []
synonym: "OMeThr" EXACT PSI-MOD-label []
synonym: "threonine methyl ether" EXACT RESID-alternate []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 5 H 9 N 1 O 2"
xref: MassAvg: "115.13"
xref: MassMono: "115.063329"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0356
is_a: MOD:01803 ! O-methylated threonine

[Term]
id: MOD:01388
name: 1-amino-2-propanol
def: "A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanol." [ChEBI:15675, PubMed:7328054, RESID:AA0465]
synonym: "(2R)-1-aminopropan-2-ol" EXACT RESID-systematic []
synonym: "1-amino-2-hydroxypropane" EXACT RESID-alternate []
synonym: "1-amino-2-propanol" EXACT RESID-name []
synonym: "1-methyl-2-aminoethanol" EXACT RESID-alternate []
synonym: "2-amino-1-methylethanol" EXACT RESID-alternate []
synonym: "2-hydroxy-1-propylamine" EXACT RESID-alternate []
synonym: "2-hydroxypropanamine" EXACT RESID-alternate []
synonym: "2-hydroxypropylamine" EXACT RESID-alternate []
synonym: "alpha-aminoisopropyl alcohol" EXACT RESID-alternate []
synonym: "dCbxThr" EXACT PSI-MOD-label []
synonym: "decarboxylated threonine" EXACT RESID-alternate []
synonym: "isopropanolamine" EXACT RESID-alternate []
synonym: "MOD_RES Decarboxylated threonine" EXACT UniProt-feature []
synonym: "threamine" EXACT RESID-alternate []
xref: DiffAvg: "-44.01"
xref: DiffFormula: "C -1 H 0 N 0 O -2"
xref: DiffMono: "-43.989829"
xref: Formula: "C 3 H 8 N 1 O 1"
xref: MassAvg: "74.10"
xref: MassMono: "74.060589"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0354
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:00960 ! decarboxylated residue

[Term]
id: MOD:01389
name: L-isoleucine thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-isoleucine residue to form L-isoleucine thiazole-4-carboxylic acid." [PubMed:11320328, RESID:AA0466]
comment: Cross-link 2.
synonym: "2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1-zanyl-2-methylbutyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Thiazole-4-carboxylic acid (Ile-Cys)" EXACT UniProt-feature []
synonym: "L-isoleucine thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 9 H 12 N 2 O 1 S 1"
xref: MassAvg: "196.27"
xref: MassMono: "196.067034"
xref: Origin: "C, I"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0361
is_a: MOD:02049 ! crosslinked L-isoleucine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01390
name: L-valine thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue to form L-valine thiazole-4-carboxylic acid." [PubMed:7328054, RESID:AA0467]
comment: Cross-link 2.
synonym: "2-[(1S)-1-amino-2-methylpropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1-azanyl-2-methylpropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Thiazole-4-carboxylic acid (Val-Cys)" EXACT UniProt-feature []
synonym: "L-valine thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 8 H 10 N 2 O 1 S 1"
xref: MassAvg: "182.24"
xref: MassMono: "182.051384"
xref: Origin: "C, V"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0365
is_a: MOD:02059 ! crosslinked L-valine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01391
name: L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue, and C-5 methoxymethylates to form L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid." [PubMed:10625477, PubMed:1880060, PubMed:7844053, RESID:AA0468]
comment: Cross-link 2.
synonym: "2-[(1S)-1-amino-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1-azanyl-2-methylpropyl]-5-(methoxymethyl)-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK 5-(methoxymethyl)thiazole-4-carboxylic acid (Val-Cys)" EXACT UniProt-feature []
synonym: "L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "24.02"
xref: DiffFormula: "C 2 H 0 N 0 O 0 S 0"
xref: DiffMono: "24.000000"
xref: Formula: "C 10 H 14 N 2 O 2 S 1"
xref: MassAvg: "226.29"
xref: MassMono: "226.077599"
xref: Origin: "C, V"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0373
is_a: MOD:02059 ! crosslinked L-valine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues

[Term]
id: MOD:01392
name: L-asparagine 5-methylthiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue, and C-4 methylates to form L-asparagine 5-methylthiazole-4-carboxylic acid." [PubMed:10625477, PubMed:1880060, PubMed:7844053, RESID:AA0469]
comment: Cross-link 2.
synonym: "2-[(1S)-1,3-bisazanyl-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "2-[(1S)-1,3-diamino-3-oxopropyl]-5-methyl-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "CROSSLNK 5-methylthiazole-4-carboxylic acid (Asn-Cys)" EXACT UniProt-feature []
synonym: "L-asparagine 5-methylthiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-6.00"
xref: DiffFormula: "C 1 H -2 N 0 O -1 S 0"
xref: DiffMono: "-6.010565"
xref: Formula: "C 8 H 9 N 3 O 2 S 1"
xref: MassAvg: "211.24"
xref: MassMono: "211.041548"
xref: Origin: "C, N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0352
is_a: MOD:02042 ! crosslinked L-asparagine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
relationship: derives_from MOD:00656 ! C-methylated residue

[Term]
id: MOD:01393
name: L-cysteine pyridine-2,5-dicarboxylic acid
def: "A protein modification that crosslinks two serine residues and a cysteine residue by formation of a pyridine-2,5-dicarboxylic acid." [PubMed:10625477, PubMed:1880060, PubMed:7844053, RESID:AA0470]
comment: Cross-link 3.
synonym: "6-[(1R)-1-amino-2-sulfanylethyl]pyridine-2,5-dicarboxylic acid" EXACT RESID-systematic []
synonym: "L-cysteine pyridine-2,5-dicarboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-70.07"
xref: DiffFormula: "C 0 H -8 N -1 O -3 S 0"
xref: DiffMono: "-70.050418"
xref: Formula: "C 9 H 7 N 2 O 2 S 1"
xref: MassAvg: "207.23"
xref: MassMono: "207.022823"
xref: Origin: "C, S, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0358
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01425 ! pyridinyl ring crosslinked residues

[Term]
id: MOD:01394
name: L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid
def: "A protein modification that crosslinks two serine residues and a cysteine residue by formation of a 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid." [PubMed:11320328, RESID:AA0471]
comment: Cross-link 3.
synonym: "(5R,6R)-5-amino-6-[(1R)-1-amino-2-sulfanylethyl]-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid" EXACT RESID-systematic []
synonym: "L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid" EXACT RESID-name []
synonym: "L-cysteine 5-aminopiperideine-2,5-dicarboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK 5-amino-piperideine-2,5-dicarboxylic acid" RELATED UniProt-feature []
xref: DiffAvg: "-53.04"
xref: DiffFormula: "C 0 H -5 N 0 O -3 S 0"
xref: DiffMono: "-53.023869"
xref: Formula: "C 9 H 11 N 3 O 2 S 1"
xref: MassAvg: "225.27"
xref: MassMono: "225.057198"
xref: Origin: "C, S, S"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0348
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01425 ! pyridinyl ring crosslinked residues

[Term]
id: MOD:01395
name: 4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol
def: "A protein modification that effectively results from forming an adduct between an isoleucine residue, a threonine residue and the quinaldate compound 2-carboxy-4-(1-hydroxyethyl)--7,8-dihydroquinolin-8-ol." [PubMed:11320328, RESID:AA0472]
comment: Cross-link 2.
synonym: "(7R,8S)-7-[(1S,2S)-1-carboxy-2-methylbutyl]amino-2-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)carbonyl-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7,8-dihydroquinoline" EXACT RESID-systematic []
synonym: "4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol" EXACT RESID-name []
synonym: "BINDING 4-(1-hydroxyethyl)-7,8-dihydroquinolin-8-ol (covalent; via 2 links)" EXACT UniProt-feature []
xref: DiffAvg: "215.21"
xref: DiffFormula: "C 12 H 9 N 1 O 3"
xref: DiffMono: "215.058243"
xref: Formula: "C 22 H 28 N 3 O 6"
xref: MassAvg: "430.48"
xref: MassMono: "430.197811"
xref: Origin: "I, T"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:02049 ! crosslinked L-isoleucine residue
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:01424 ! quinaldate modified residue

[Term]
id: MOD:01396
name: 5-hydroxy-3-methyl-L-proline (Pro)
def: "A protein modification that effectively converts an L-proline residue to a 5-hydroxy-3-methyl-L-proline." [PubMed:7592021, PubMed:8557573, RESID:AA0473]
comment: This entry is for the hypothetical formation of 5-hydroxy-3-methyl-L-proline from proline. For the natural production from L-isoleucine, use MOD:01897 [JSG].
synonym: "(2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "5-hydroxy-3-methyl-L-proline" EXACT RESID-name []
synonym: "5-hydroxy-3-methylproline" EXACT RESID-alternate []
synonym: "5Hy3MePro" EXACT PSI-MOD-label []
synonym: "beta-methyl-delta-hydroxyproline" EXACT RESID-alternate []
synonym: "MOD_RES 5-hydroxy-3-methylproline (Ile)" EXACT UniProt-feature []
xref: DiffAvg: "30.03"
xref: DiffFormula: "C 1 H 2 N 0 O 1"
xref: DiffMono: "30.010565"
xref: Formula: "C 6 H 9 N 1 O 2"
xref: MassAvg: "127.14"
xref: MassMono: "127.063329"
xref: Origin: "P"
xref: Source: "artifactual"
xref: TermSpec: "none"
is_a: MOD:00915 ! modified L-proline residue
relationship: has_functional_parent MOD:01024 ! monohydroxylated proline
relationship: has_functional_parent MOD:01417 ! monomethylated proline

[Term]
id: MOD:01397
name: L-serine 5-methyloxazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazole-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0474]
comment: Cross-link 2.
synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1-azanyl-2-hydroxyethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK 5-methyloxazole-4-carboxylic acid (Ser-Thr)" EXACT UniProt-feature []
synonym: "L-serine 5-methyloxazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1"
xref: DiffMono: "-20.026215"
xref: Formula: "C 7 H 8 N 2 O 3"
xref: MassAvg: "168.15"
xref: MassMono: "168.053492"
xref: Origin: "S, T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0386
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr)
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01398
name: N6-propanoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-propanoyl-L-lysine." [PubMed:17267393, PubMed:17684016, PubMed:20715035, RESID:AA0475, Unimod:58#K]
comment: The binding of histone peptides with propanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG].
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-(propanoylamino)hexanoic acid" EXACT RESID-systematic []
synonym: "2-amino-6-propionylaminocaproic acid" EXACT RESID-alternate []
synonym: "epsilon-propanoyl-L-lysine" EXACT RESID-alternate []
synonym: "epsilon-propionyl-L-lysine" EXACT RESID-alternate []
synonym: "N(zeta)-propanoyllysine" EXACT RESID-alternate []
synonym: "N6-(1-oxopropyl)-L-lysine" EXACT RESID-alternate []
synonym: "N6-propanoyl-L-lysine" EXACT RESID-name []
synonym: "N6-propionyllysine" EXACT RESID-alternate []
synonym: "MOD_RES N6-propionyllysine" EXACT UniProt-feature []
xref: DiffAvg: "56.06"
xref: DiffFormula: "C 3 H 4 N 0 O 1"
xref: DiffMono: "56.026215"
xref: Formula: "C 9 H 16 N 2 O 2"
xref: MassAvg: "184.24"
xref: MassMono: "184.121178"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:58"
xref: uniprot.ptm:PTM-0642
is_a: MOD:01155 ! lipoconjugated residue
is_a: MOD:01875 ! N6-acylated L-lysine
is_a: MOD:01894 ! propanoylated residue

[Term]
id: MOD:01399
name: N6-(ADP-ribosyl)-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to an N6-(ADP-ribosyl)-L-lysine." [PubMed:18436469, RESID:AA0476]
synonym: "(S)-2-amino-6-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "2-amino-6-(ADP-ribosyl)amino-hexanoic acid" EXACT RESID-alternate []
synonym: "epsilon-ADP-ribosyllysine" EXACT RESID-alternate []
synonym: "MOD_RES N6-(ADP-ribosyl)lysine" EXACT UniProt-feature []
synonym: "N(zeta)-ADP-ribosyllysine" EXACT RESID-alternate []
synonym: "N6-(ADP-ribosyl)-L-lysine" EXACT RESID-name []
synonym: "N6-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-lysine" EXACT RESID-alternate []
synonym: "N6-alpha-D-ribofuranosyl-L-lysine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate []
xref: DiffAvg: "541.30"
xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2"
xref: DiffMono: "541.061109"
xref: Formula: "C 21 H 33 N 7 O 14 P 2"
xref: MassAvg: "669.48"
xref: MassMono: "669.156072"
xref: Origin: "K"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0355
is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01400
name: L-lysyl-poly(ADP-ribose)
def: "A protein modification that effectively converts an L-lysine residue to an L-lysyl-poly(ADP-ribose)." [PubMed:6772638, RESID:AA0477]
synonym: "L-lysyl-poly(ADP-ribose)" EXACT RESID-name []
synonym: "MOD_RES Lysyl poly(ADP-ribose)" EXACT UniProt-feature []
synonym: "poly[2'-adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with 1alpha-D-ribofuranosyl] (2S)-2,6-diaminohexanoate" EXACT RESID-systematic []
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:02087 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01401
name: (2S,3S)-3-hydroxyasparagine
def: "A protein modification that effectively converts an L-asparagine residue to a (2S,3S)-3-hydroxyasparagine." [ChEBI:50789, PubMed:11823643, PubMed:12042299, PubMed:12215170, PubMed:17573339, RESID:AA0478, ChEBI:138107]
subset: PSI-MOD-slim
synonym: "(2S,3S)-2,4-diamino-3-hydroxy-4-oxobutanoic acid" EXACT RESID-alternate []
synonym: "(2S,3S)-2-amino-3-hydroxy-4-butanediamic acid" EXACT RESID-systematic []
synonym: "(2S,3S)-3-hydroxyasparagine" EXACT RESID-name []
synonym: "(3S)3HyAsn" EXACT PSI-MOD-label []
synonym: "L-threo-beta-hydroxyasparagine" EXACT RESID-alternate []
synonym: "MOD_RES (3S)-3-hydroxyasparagine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 4 H 6 N 2 O 3"
xref: MassAvg: "130.10"
xref: MassMono: "130.037842"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0370
is_a: MOD:01688 ! 3-hydroxy-L-asparagine

[Term]
id: MOD:01402
name: (2S,3R,4R)-3,4-dihydroxyproline
def: "A protein modification that effectively converts an L-proline residue to a (2S,3R,4R)-3,4-dihydroxyproline." [PubMed:6893271, RESID:AA0479, ChEBI:141805]
synonym: "(2S,3R,4R)-3,4-dihydroxyproline" EXACT RESID-name []
synonym: "(2S,3R,4R)-3,4-dihydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "2,3-trans-3,4-trans-3,4-dihydroxy-L-proline" EXACT RESID-alternate []
synonym: "2-alpha-3-beta-4-alpha-3,4-dihydroxyproline" EXACT RESID-alternate []
synonym: "MOD_RES (3R,4R)-3,4-dihydroxyproline" EXACT UniProt-feature []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0368
is_a: MOD:00866 ! dihydroxylated proline

[Term]
id: MOD:01403
name: (2S)-4,5,5'-trihydroxyleucine
def: "A protein modification that effectively converts an L-leucine residue to a (2S)-4,5,5'-trihydroxyleucine." [PubMed:6893271, RESID:AA0480]
synonym: "(2S)-2-amino-4,5-dihydroxy-4-(hydroxymethyl)pentanoic acid" EXACT RESID-systematic []
synonym: "(2S)-4,5,5'-trihydroxyleucine" EXACT RESID-name []
synonym: "4,5,5'-trihydroxyleucine" EXACT RESID-alternate []
synonym: "gamma,delta,delta'-trihydroxyleucine" EXACT RESID-alternate []
synonym: "MOD_RES 4,5,4'-trihydroxyleucine" EXACT UniProt-feature []
xref: DiffAvg: "48.00"
xref: DiffFormula: "C 0 H 0 N 0 O 3"
xref: DiffMono: "47.984744"
xref: Formula: "C 6 H 11 N 1 O 4"
xref: MassAvg: "161.16"
xref: MassMono: "161.068808"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0372
is_a: MOD:01413 ! trihydroxylated leucine

[Term]
id: MOD:01404
name: L-asparagine thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue to form L-asparagine thiazole-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0481]
comment: Cross-link 2.
synonym: "2-[(1S)-1,3-diamino-3-oxopropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1,3-bisazanyl-3-oxopropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Thiazole-4-carboxylic acid (Asn-Cys)" EXACT UniProt-feature []
synonym: "L-asparagine thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 7 H 7 N 3 O 2 S 1"
xref: MassAvg: "197.21"
xref: MassMono: "197.025897"
xref: Origin: "C, N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0359
is_a: MOD:02042 ! crosslinked L-asparagine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01405
name: L-proline thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-proline residue to form L-proline thiazole-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0482]
comment: Cross-link 2.
synonym: "2-[(2S)-pyrrolidin-2-yl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Thiazole-4-carboxylic acid (Pro-Cys)" EXACT UniProt-feature []
synonym: "L-proline thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 8 H 8 N 2 O 1 S 1"
xref: MassAvg: "180.22"
xref: MassMono: "180.035734"
xref: Origin: "C, P"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02054 ! crosslinked L-proline residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01406
name: L-threonine thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazole-4-carboxylic acid." [PubMed:11320328, RESID:AA0483]
comment: Cross-link 2.
synonym: "2-[(1S,2R)-1-amino-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1-azanyl-2-hydroxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Thiazole-4-carboxylic acid (Thr-Cys)" EXACT UniProt-feature []
synonym: "L-threonine thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 7 H 8 N 2 O 2 S 1"
xref: MassAvg: "184.21"
xref: MassMono: "184.030649"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0364
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01407
name: L-phenylalanine thiazoline-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazoline-4-carboxylic acid." [PubMed:7592021, PubMed:8557573, RESID:AA0484]
comment: Cross-link 2.
synonym: "(4R)-2-[(1S)-1-amino-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1-azanyl-2-phenylethyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Thiazoline-4-carboxylic acid (Phe-Cys)" EXACT UniProt-feature []
synonym: "L-phenylalanine thiazoline-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 12 H 12 N 2 O 1 S 1"
xref: MassAvg: "232.30"
xref: MassMono: "232.067034"
xref: Origin: "C, F"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0366
is_a: MOD:02053 ! crosslinked L-phenylalanine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01408
name: L-threonine thiazoline-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazoline-4-carboxylic acid." [PubMed:11320328, RESID:AA0485]
comment: Cross-link 2.
synonym: "(4S)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[1-azanyl-2-hydroxypropyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK (4S)-thiazoline-4-carboxylic acid (Thr-Cys)" EXACT UniProt-feature []
synonym: "L-threonine (4S)-thiazoline-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 7 H 10 N 2 O 2 S 1"
xref: MassAvg: "186.23"
xref: MassMono: "186.046299"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0392
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01409
name: trihydroxylated residue
def: "A protein modification that effectively replaces three hydrogen atoms with three hydroxyl groups." [PubMed:18688235]
synonym: "Hy3Res" EXACT PSI-MOD-label []
xref: DiffAvg: "48.00"
xref: DiffFormula: "C 0 H 0 N 0 O 3"
xref: DiffMono: "47.984744"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00677 ! hydroxylated residue

[Term]
id: MOD:01410
name: hydroxylated leucine
def: "A protein modification that effectively converts an L-leucine residue to an hydroxylated leucine." [PubMed:18688235]
synonym: "HyLeu" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "L"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00677 ! hydroxylated residue
is_a: MOD:00911 ! modified L-leucine residue

[Term]
id: MOD:01411
name: monohydroxylated leucine
def: "A protein modification that effectively converts an L-leucine residue to a monohydroxylated leucine." [PubMed:18688235]
synonym: "Hy1Leu" EXACT PSI-MOD-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 11 N 1 O 2"
xref: MassAvg: "129.16"
xref: MassMono: "129.078979"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:01410 ! hydroxylated leucine

[Term]
id: MOD:01412
name: dihydroxylated leucine
def: "A protein modification that effectively converts an L-leucine residue to a dihydroxylated leucine." [PubMed:18688235]
synonym: "Hy2Leu" EXACT PSI-MOD-label []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 6 H 11 N 1 O 3"
xref: MassAvg: "145.16"
xref: MassMono: "145.073893"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00428 ! dihydroxylated residue
is_a: MOD:01410 ! hydroxylated leucine

[Term]
id: MOD:01413
name: trihydroxylated leucine
def: "A protein modification that effectively converts an L-leucine residue to a trihydroxylated leucine." [PubMed:18688235]
synonym: "Hy3Leu" EXACT PSI-MOD-label []
xref: DiffAvg: "48.00"
xref: DiffFormula: "C 0 H 0 N 0 O 3"
xref: DiffMono: "47.984744"
xref: Formula: "C 6 H 11 N 1 O 4"
xref: MassAvg: "161.16"
xref: MassMono: "161.068808"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01409 ! trihydroxylated residue
is_a: MOD:01410 ! hydroxylated leucine

[Term]
id: MOD:01414
name: hydroxylated isoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to an hydroxylated isoleucine." [PubMed:18688235]
synonym: "HyIle" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "I"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00677 ! hydroxylated residue
is_a: MOD:00910 ! modified L-isoleucine residue

[Term]
id: MOD:01415
name: monohydroxylated isoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to a monohydroxylated isoleucine." [PubMed:18688235]
synonym: "Hy1Ile" EXACT PSI-MOD-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 11 N 1 O 2"
xref: MassAvg: "129.16"
xref: MassMono: "129.078979"
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:01414 ! hydroxylated isoleucine

[Term]
id: MOD:01416
name: dihydroxylated isoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to a dihydroxylated isoleucine." [PubMed:18688235]
synonym: "Hy2Ile" EXACT PSI-MOD-label []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 6 H 11 N 1 O 3"
xref: MassAvg: "145.16"
xref: MassMono: "145.073893"
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00428 ! dihydroxylated residue
is_a: MOD:01414 ! hydroxylated isoleucine

[Term]
id: MOD:01417
name: monomethylated proline
def: "A protein modification that effectively converts an L-proline residue to a monomethylated proline." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "Me1Pro" EXACT PSI-MOD-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 6 H 10 N 1 O 1"
xref: MassAvg: "112.15"
xref: MassMono: "112.076239"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00712 ! methylated proline

[Term]
id: MOD:01418
name: methylated threonine
def: "A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine." [PubMed:18688235]
synonym: "MeThr" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01419
name: oxazole/oxazoline ring crosslinked residues
def: "A protein modification that crosslinks two residues by condensation of a serine or threonine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring, or by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid." [PubMed:18688235]
is_a: MOD:00690 ! oxazole/thiazole ring crosslinked residues

[Term]
id: MOD:01420
name: thiazole/thiazoline ring crosslinked residues
def: "A protein modification that crosslinks two residues by condensation of a cysteine thiol with the carbonyl of the preceding residue to form a thiazole or thiazoline ring." [PubMed:18688235]
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00687 ! thioether crosslinked residues
is_a: MOD:00690 ! oxazole/thiazole ring crosslinked residues

[Term]
id: MOD:01421
name: oxazole/oxazoline ring crosslinked residues (Ser)
def: "A protein modification that crosslinks two residues by condensation of a serine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring." [PubMed:18688235]
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01419 ! oxazole/oxazoline ring crosslinked residues

[Term]
id: MOD:01422
name: oxazole/oxazoline ring crosslinked residues (Thr)
def: "A protein modification that crosslinks two residues by condensation of a threonine hydroxyl with the carbonyl of the preceding residue to form a 5-methyloxazole or 5-methyloxazoline ring." [PubMed:18688235]
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:01419 ! oxazole/oxazoline ring crosslinked residues

[Term]
id: MOD:01423
name: palmitoleylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a palmitoleyl group." [Unimod:431]
subset: PSI-MOD-slim
xref: DiffAvg: "236.40"
xref: DiffFormula: "C 16 H 28 N 0 O 1"
xref: DiffMono: "236.214016"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:431"
is_a: MOD:00649 ! acylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:01424
name: quinaldate modified residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a quinaldate, kynurenate, or xanthurenate group." [PubMed:18688235]
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:01425
name: pyridinyl ring crosslinked residues
def: "A protein modification that crosslinks three residues by formation of a pyridinyl ring, such as pyridine-2,5-dicarboxylic acid or 5-aminopiperideine-2,5-dicarboxylic acid." [PubMed:18688235]
comment: Cross-link 3.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00033 ! crosslinked residues

[Term]
id: MOD:01426
name: isotope tagged reagent derivatized residue
def: "A protein modification that forms an adduct with a particular isotope labeled compound used as a reagent." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01427
name: 2-aminobutanoic acid (Abu)
def: "OBSOLETE because redundant and identical to MOD:00819. Remap to MOD:00819." [PubMed:18688235]
synonym: "Abu" EXACT DeltaMass-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 4 H 7 N 1 O 1"
xref: MassAvg: "85.11"
xref: MassMono: "85.052764"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Remap: "MOD:00819"
is_obsolete: true

[Term]
id: MOD:01428
name: (13)C isotope tagged reagent
def: "A protein modification that forms an adduct with a (13)C labeled compound used as a reagent." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01426 ! isotope tagged reagent derivatized residue
is_a: MOD:00842 ! (13)C labeled residue

[Term]
id: MOD:01429
name: (15)N isotope tagged reagent
def: "A protein modification that forms an adduct with a (15)N labeled compound used as a reagent." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01426 ! isotope tagged reagent derivatized residue
is_a: MOD:00843 ! (15)N labeled residue

[Term]
id: MOD:01430
name: (18)O isotope tagged reagent
def: "A protein modification that forms an adduct with a (13)C labeled compound used as a reagent." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01426 ! isotope tagged reagent derivatized residue
is_a: MOD:00844 ! (18)O labeled residue

[Term]
id: MOD:01431
name: (2)H deuterium tagged reagent
def: "A protein modification that forms an adduct with a (2)H labeled compound used as a reagent." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01426 ! isotope tagged reagent derivatized residue
is_a: MOD:00839 ! (2)H deuterium labeled residue

[Term]
id: MOD:01432
name: (2S,4S)-4,5-dihydroxyleucine
def: "A protein modification that effectively converts an L-leucine residue to a (2S,4S)-4,5-dihydroxyleucine." [PubMed:3718926, RESID:AA0446, ChEBI:141819]
synonym: "(2S,4S)-2-amino-4,5-dihydroxy-4-methylpentanoic acid" EXACT RESID-systematic []
synonym: "(2S,4S)-4,5-dihydroxyleucine" EXACT RESID-name []
synonym: "(4S)-4,5-dihydroxyleucine" EXACT RESID-alternate []
synonym: "gamma,delta-dihydroxyleucine" EXACT RESID-alternate []
synonym: "MOD_RES (4S)-4,5-dihydroxyleucine" EXACT UniProt-feature []
xref: DiffAvg: "32.00"
xref: DiffFormula: "C 0 H 0 N 0 O 2"
xref: DiffMono: "31.989829"
xref: Formula: "C 6 H 11 N 1 O 3"
xref: MassAvg: "145.16"
xref: MassMono: "145.073893"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0666
is_a: MOD:01412 ! dihydroxylated leucine

[Term]
id: MOD:01433
name: 1-amino-2-propanone
def: "A protein modification that effectively converts an L-threonine residue into 1-amino-2-propanone." [ChEBI:17906, PubMed:12715872, PubMed:19196969, RESID:AA0486]
synonym: "1-amino-2-propanone" EXACT RESID-name []
synonym: "1-aminopropan-2-one" EXACT RESID-alternate []
synonym: "1-aminopropanone" EXACT RESID-systematic []
synonym: "aminoacetone" EXACT RESID-alternate []
synonym: "MOD_RES 1-amino-2-propanone" EXACT UniProt-feature []
xref: DiffAvg: "-46.03"
xref: DiffFormula: "C -1 H -2 N 0 O -2"
xref: DiffMono: "-46.005479"
xref: Formula: "C 3 H 6 N 1 O 1"
xref: MassAvg: "72.09"
xref: MassMono: "72.044939"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0379
is_a: MOD:00683 ! dehydrogenated residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01434
name: 4-hydroxy-L-glutamic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to a 4-hydroxy-L-glutamic acid." [PubMed:893891, RESID:AA0487, ChEBI:141845]
synonym: "(2S,4Xi)-2-amino-4-hydroxypentanedioic acid" EXACT RESID-systematic []
synonym: "4-hydroxy-L-glutamic acid" EXACT RESID-name []
synonym: "gamma-hydroxy glutaminic acid" EXACT RESID-alternate []
synonym: "MOD_RES 4-hydroxyglutamate" EXACT UniProt-feature []
synonym: "threo-4-hydroxy-L-glutamic acid" EXACT RESID-alternate []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 7 N 1 O 4"
xref: MassAvg: "145.11"
xref: MassMono: "145.037508"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0453
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:01435
name: 2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole
def: "A protein modification that effectively results from forming an adduct between a cysteine residue, a glutamic acid residue and the indole compound 2-carboxy-3-methyl-4-hydroxymethyl--indole." [PubMed:893891, RESID:AA0488]
comment: Cross-link 2.
synonym: "2-([(1R)-1-amino-1-carboxyeth-2-yl]sulfanyl)carbonyl-3-methyl-4-([(1S)-1-amino-1-carboxy-4-oxobutan-4-yl]oxy)methyl-1H-indole" EXACT RESID-systematic []
synonym: "2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole" EXACT RESID-name []
synonym: "2-(cystein-S-ylcarbonyl)-4-[(glutam-5-yloxy)methyl]-3-methyl-1H-indole" EXACT RESID-alternate []
synonym: "BINDING 3-methyl-4-hydroxymethylindole-2-carboxylic acid (covalent; via 2 links)" EXACT UniProt-feature []
xref: DiffAvg: "169.18"
xref: DiffFormula: "C 11 H 7 N 1 O 1 S 0"
xref: DiffMono: "169.052764"
xref: Formula: "C 19 H 19 N 3 O 5 S 1"
xref: MassAvg: "401.44"
xref: MassMono: "401.104542"
xref: Origin: "C, E"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00672 ! S-acylated residue
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02045 ! crosslinked L-glutamic acid residue

[Term]
id: MOD:01436
name: cyclo[(prolylserin)-O-yl] cysteinate (Cys)
def: "A protein modification that effectively converts an L-cysteine residue to cyclo[(prolylserin)-O-yl] cysteinate." [PubMed:7961166, RESID:AA0489#CYS]
synonym: "(3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate" EXACT RESID-alternate []
synonym: "[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic []
synonym: "cyclo[(prolylserin)-O-yl] cysteinate" EXACT RESID-name []
synonym: "MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate" EXACT UniProt-feature []
xref: DiffAvg: "166.18"
xref: DiffFormula: "C 8 H 10 N 2 O 2 S 0"
xref: DiffMono: "166.074228"
xref: Formula: "C 11 H 16 N 3 O 4 S 1"
xref: MassAvg: "286.33"
xref: MassMono: "286.086152"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:01629 ! cyclo[(prolylserin)-O-yl] cysteinate

[Term]
id: MOD:01437
name: cyclo[(prolylserin)-O-yl] cysteinate (Cys-Pro-Ser cross-link)
def: "A protein modification that effectively converts an L-cysteine residue, an L-proline residue, and an L-serine residue to cyclo[(prolylserin)-O-yl] cysteinate." [PubMed:7961166, RESID:AA0489#TRI]
comment: Cross-link 3.
synonym: "(3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate" EXACT RESID-alternate []
synonym: "[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic []
synonym: "cyclo[(prolylserin)-O-yl] cysteinate" EXACT RESID-name []
synonym: "MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate" EXACT UniProt-feature []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 11 H 16 N 3 O 4 S 1"
xref: MassAvg: "286.33"
xref: MassMono: "286.086152"
xref: Origin: "C, P, S"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0380
is_a: MOD:02054 ! crosslinked L-proline residue
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01629 ! cyclo[(prolylserin)-O-yl] cysteinate
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01438
name: S-[2-(pyridin-2-yl)ethyl]-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-2-yl)ethyl]-L-cysteine." [PubMed:18369855, PubMed:18688235]
comment: From DeltaMass: (name misspelled "Pyridylethyl Cystenyl", and formula incorrect, N and O reversed) Formula: C10H12O2N1S1 Monoisotopic Mass Change: 208.067 Average Mass Change: 208.286
synonym: "2-PEC" EXACT PSI-MOD-alternate []
synonym: "2-vinylpyridine derivatized cysteine residue" EXACT PSI-MOD-alternate []
synonym: "Pyridylethyl" RELATED PSI-MS-label []
synonym: "Pyridylethyl Cystenyl" EXACT DeltaMass-label []
synonym: "S-(pyridin-2-ylethyl)-L-cysteine" EXACT PSI-MOD-alternate []
synonym: "S-pyridylethylation" RELATED Unimod-description []
xref: DiffAvg: "105.14"
xref: DiffFormula: "C 7 H 7 N 1"
xref: DiffMono: "105.057849"
xref: Formula: "C 10 H 12 N 2 O 1 S 1"
xref: MassAvg: "208.28"
xref: MassMono: "208.067034"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00424 ! S-pyridylethyl-L-cysteine

[Term]
id: MOD:01439
name: S-[2-(pyridin-4-yl)ethyl]-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-4-yl)ethyl]-L-cysteine." [PubMed:18688235, PubMed:6528972]
synonym: "4-PEC" EXACT PSI-MOD-alternate []
synonym: "Pyridylethyl" RELATED PSI-MS-label []
synonym: "Pyridylethyl Cystenyl" EXACT DeltaMass-label []
synonym: "S-(pyridin-4-ylethyl)-L-cysteine" EXACT PSI-MOD-alternate []
synonym: "S-pyridylethylation" RELATED Unimod-description []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00424 ! S-pyridylethyl-L-cysteine

[Term]
id: MOD:01440
name: glutamyl semialdehyde
def: "A protein modification that effectively converts a source amino acid residue to an L-glutamyl semialdehyde." [PubMed:18688235]
synonym: "(S)-2-amino-5-oxopentanoic acid" EXACT PSI-MOD-alternate []
synonym: "L-glutamic gamma-semialdehyde" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 5 H 7 N 1 O 2"
xref: MassAvg: "113.12"
xref: MassMono: "113.047678"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:00594 ! residues isobaric at 113.047678 Da

[Term]
id: MOD:01441
name: natural, standard, encoded residue
def: "A protein modification that inserts or replaces a residue with a natural, standard, encoded residue." [PubMed:18688235, PubMed:6692818]
subset: PSI-MOD-slim
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00009 ! natural residue

[Term]
id: MOD:01442
name: 3-(O4'-L-tyrosyl)-L-valine
def: "A protein modification that effectively cross-links an L-valine residue and an L-tyrosine residue by an ether bond to form 3-(O4'-L-tyrosyl)-L-valine." [PubMed:19321420, RESID:AA0490]
comment: Cross-link 2.
synonym: "(2S)-2-amino-3-(4-[(2S)-2-amino-2-carboxyethyl]phenoxy)-3-methylbutanoic acid" EXACT RESID-systematic []
synonym: "3-(O4'-L-tyrosyl)-L-valine" EXACT RESID-name []
synonym: "CROSSLNK 3-(O4'-tyrosyl)-valine (Val-Tyr)" EXACT UniProt-feature []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 14 H 16 N 2 O 3"
xref: MassAvg: "260.29"
xref: MassMono: "260.116092"
xref: Origin: "V, Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0390
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02058 ! crosslinked L-tyrosine residue
is_a: MOD:02059 ! crosslinked L-valine residue

[Term]
id: MOD:01443
name: tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide
def: "A protein modification that effectively converts four L-glutamic acid residues and two L-histidine residues to tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide." [PubMed:19321420, RESID:AA0491]
comment: Cross-link 6. It is not clear whether the lipid carboxylate is a cofactor or a substrate, and its identity is not certain. It was modeled as myristic acid [JSG].
xref: DiffAvg: "350.12"
xref: DiffFormula: "C 14 Fe 1 H 23 Mn 1 N 0 O 3"
xref: DiffMono: "350.038251"
xref: FormalCharge: "1-"
xref: Formula: "C 46 Fe 1 H 65 Mn 1 N 10 O 17"
xref: MassAvg: "1140.86"
xref: MassMono: "1140.326447"
xref: Origin: "E, E, E, E, H, H"
xref: Source: "natural"
xref: TermSpec: "none"
relationship: contains MOD:00438 ! myristoylated residue
is_a: MOD:00738 ! iron containing modified residue
is_a: MOD:00740 ! manganese containing modified residue
is_a: MOD:02068 ! metal or metal cluster coordinated L-glutamic acid residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:01444
name: L-3,3-dihydroxyoalanine (Cys)
def: "A protein modification that effectively converts an L-cysteine residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, RESID:AA0492#CYS]
synonym: "(S)-2-amino-3,3-dihydroxypropanoic acid" EXACT RESID-systematic []
synonym: "2-(dihydroxymethyl)glycine" EXACT RESID-alternate []
synonym: "3,3-dihydroxy-L-alanine" EXACT RESID-name []
synonym: "3,3-dihydroxyalanine" EXACT RESID-alternate []
synonym: "3-hydroxy-L-serine" EXACT RESID-alternate []
synonym: "3-oxoalanine hydrate" EXACT RESID-alternate []
synonym: "C(alpha)-formylglycine hydrate" RELATED RESID-misnomer []
xref: DiffAvg: "-0.06"
xref: DiffFormula: "C 0 H 0 N 0 O 2 S -1"
xref: DiffMono: "0.017758"
xref: Formula: "C 3 H 5 N 1 O 3"
xref: MassAvg: "103.08"
xref: MassMono: "103.026943"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01448 ! L-3,3-dihydroxyoalanine

[Term]
id: MOD:01445
name: L-3,3-dihydroxyoalanine (Ser)
def: "A protein modification that effectively converts an L-serine residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, RESID:AA0492#SER]
synonym: "(S)-2-amino-3,3-dihydroxypropanoic acid" EXACT RESID-systematic []
synonym: "2-(dihydroxymethyl)glycine" EXACT RESID-alternate []
synonym: "3,3-dihydroxy-L-alanine" EXACT RESID-name []
synonym: "3,3-dihydroxyalanine" EXACT RESID-alternate []
synonym: "3-hydroxy-L-serine" EXACT RESID-alternate []
synonym: "3-oxoalanine hydrate" EXACT RESID-alternate []
synonym: "C(alpha)-formylglycine hydrate" RELATED RESID-misnomer []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 3 H 5 N 1 O 3"
xref: MassAvg: "103.08"
xref: MassMono: "103.026943"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01448 ! L-3,3-dihydroxyoalanine

[Term]
id: MOD:01446
name: N-(dihydroxymethyl)-L-methionine (fMet)
def: "A protein modification that effectively converts an N-formyl-Lmethionine residue to N-(dihydroxymethyl)-L-methionine." [PubMed:12595263, PubMed:9159480, RESID:AA0493]
synonym: "(2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "N-(dihydroxymethyl)-L-methionine" EXACT RESID-name []
synonym: "N-formyl-L-methionine hydrate" EXACT RESID-alternate []
synonym: "N-orthoformylmethionine" EXACT RESID-alternate []
xref: DiffAvg: "18.02"
xref: DiffFormula: "C 0 H 2 N 0 O 1 S 0"
xref: DiffMono: "18.010565"
xref: Formula: "C 6 H 12 N 1 O 3 S 1"
xref: MassAvg: "178.23"
xref: MassMono: "178.053789"
xref: Origin: "MOD:00030"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
is_a: MOD:01450 ! modified N-formyl-L-methionine residue
relationship: derives_from MOD:00030 ! N-formyl-L-methionine residue

[Term]
id: MOD:01447
name: N-(dihydroxymethyl)-L-methionine (Met)
def: "A protein modification that effectively converts an L-methionine residue to N-(dihydroxymethyl)-L-methionine (not known as a natural, post-translational modification process)." [PubMed:12595263, PubMed:9159480, RESID:AA0493]
comment: This entry is for the artifactual formation of N-(dihydroxymethyl)-L-methionine from methionine. For N-(dihydroxymethyl)-L-methionine derived from encoded N-formyl-L-methionine, use MOD:01446.
synonym: "(2S)-2-[(dihydroxymethyl)amino]-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "N-(dihydroxymethyl)-L-methionine" EXACT RESID-name []
synonym: "N-formyl-L-methionine hydrate" EXACT RESID-alternate []
synonym: "N-orthoformylmethionine" EXACT RESID-alternate []
xref: DiffAvg: "46.03"
xref: DiffFormula: "C 1 H 2 N 0 O 2 S 0"
xref: DiffMono: "46.005479"
xref: Formula: "C 6 H 12 N 1 O 3 S 1"
xref: MassAvg: "178.23"
xref: MassMono: "178.053789"
xref: Origin: "M"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:01448
name: L-3,3-dihydroxyoalanine
def: "A protein modification that effectively converts a source amino acid residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, RESID:AA0492]
synonym: "(S)-2-amino-3,3-dihydroxypropanoic acid" EXACT RESID-systematic []
synonym: "2-(dihydroxymethyl)glycine" EXACT RESID-alternate []
synonym: "3,3-dihydroxy-L-alanine" EXACT RESID-name []
synonym: "3,3-dihydroxyalanine" EXACT RESID-alternate []
synonym: "3-hydroxy-L-serine" EXACT RESID-alternate []
synonym: "3-oxoalanine hydrate" EXACT RESID-alternate []
synonym: "C(alpha)-formylglycine hydrate" RELATED RESID-misnomer []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 3 H 5 N 1 O 3"
xref: MassAvg: "103.08"
xref: MassMono: "103.026943"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:01449
name: L-3,3-dihydroxyoalanine (Oxoalanine)
def: "A protein modification that effectively converts an L-3-oxoalanine residue to L-3,3-dihydroxyoalanine." [PubMed:11435113, PubMed:17558559, PubMed:18688235]
xref: DiffAvg: "18.02"
xref: DiffFormula: "C 0 H 2 N 0 O 1"
xref: DiffMono: "18.010565"
xref: Formula: "C 3 H 5 N 1 O 3"
xref: MassAvg: "103.08"
xref: MassMono: "103.026943"
xref: Origin: "MOD:01169"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01448 ! L-3,3-dihydroxyoalanine
relationship: derives_from MOD:01169 ! L-3-oxoalanine

[Term]
id: MOD:01450
name: modified N-formyl-L-methionine residue
def: "A protein modification that modifies an N-formyl-L-methionine residue." [PubMed:18688235]
xref: Origin: "MOD:00030"
xref: TermSpec: "N-term"
is_a: MOD:01157 ! protein modification categorized by amino acid modified
relationship: derives_from MOD:00030 ! N-formyl-L-methionine residue

[Term]
id: MOD:01451
name: O-phospho-L-serine arising from O-phosphopantetheine-L-serine after neutral loss of pantetheine
def: "A protein modification that converts an L-serine residue to O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine." [PubMed:17042494, PubMed:18688235]
comment: Phosphoserine is generated and detected after the facile elimination of pantetheine from the phosphopantetheine tertiary phosphodiester. See MOD:01452 for alternate origin.
subset: PSI-MOD-slim
xref: DiffAvg: "79.98"
xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "C 3 H 6 N 1 O 5 P 1"
xref: MassAvg: "167.06"
xref: MassMono: "166.998359"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00916 ! modified L-serine
is_a: MOD:00431 ! modified residue with a secondary neutral loss
relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine

[Term]
id: MOD:01452
name: O-phosphopantetheine-L-serine with neutral loss of pantetheine
def: "Covalent modification of a peptide or protein amino acid O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine." [PubMed:17042494, PubMed:18688235]
comment: Phosphoserine is generated and detected after the facile elimination of pantethiene from the phosphopantethiene tertiary phosphodiester. See MOD:01451 for alternate origin.
subset: PSI-MOD-slim
xref: DiffAvg: "-260.35"
xref: DiffFormula: "C -11 H -20 N -2 O -3 P 0 S -1"
xref: DiffMono: "-260.119464"
xref: Formula: "C 3 H 6 N 1 O 5 P 1"
xref: MassAvg: "167.06"
xref: MassMono: "166.998359"
xref: Origin: "MOD:00159"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00916 ! modified L-serine
is_a: MOD:00431 ! modified residue with a secondary neutral loss
relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine

[Term]
id: MOD:01453
name: L-glutamic acid 5-methyl ester
def: "A protein modification that effectively converts a source amino acid residue to L-glutamate 5-methyl ester." [RESID:AA0072]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-5-methoxy-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "(5)-methyl L-hydrogen glutamate" EXACT RESID-alternate []
synonym: "2-aminopentanedioic acid 5-methyl ester" EXACT RESID-alternate []
synonym: "5-methyl esterified L-glutamic acid" EXACT PSI-MOD-alternate []
synonym: "5-methyl L-2-aminoglutarate" EXACT RESID-alternate []
synonym: "5-methyl L-glutamate" EXACT RESID-alternate []
synonym: "glutamic acid 5-methyl ester" EXACT RESID-alternate []
synonym: "glutamic acid gamma-methyl ester" EXACT RESID-alternate []
synonym: "L-glutamic acid 5-methyl ester" EXACT RESID-name []
synonym: "O-methyl Glutamyl" EXACT DeltaMass-label []
synonym: "O5MeGlu" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 6 H 9 N 1 O 3"
xref: MassAvg: "143.14"
xref: MassMono: "143.058243"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00393 ! O-methylated residue
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00713 ! methylated glutamic acid
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:01454
name: N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium
def: "A protein modification that effectively crosslinks an N-terminal L-proline residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium." [PubMed:10833024, PubMed:11847126, PubMed:9030608, RESID:AA0494]
comment: This linkage is not a Schiff-base [JSG].
synonym: "(1Z,2S)-2-carboxy-1-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]pyrrolidinium" EXACT RESID-systematic []
synonym: "DNA glycosylase proline Schiff base intermediate" RELATED RESID-misnomer []
synonym: "N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium" EXACT RESID-name []
xref: FormalCharge: "1+"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00750 ! deoxyribonucleic acid linked residue
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:01455
name: O-phosphorylated residue
def: "A protein modification that effectively replaces a residue hydroxyl or carboxyl hydrogen with a phosphono group (H2PO3 or 'phosphate')." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OPhosRes" EXACT PSI-MOD-label []
xref: DiffAvg: "79.98"
xref: DiffFormula: "H 1 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00696 ! phosphorylated residue

[Term]
id: MOD:01456
name: N-phosphorylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with a phosphono group (H2PO3 or 'phosphate')." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "NPhosRes" EXACT PSI-MOD-label []
xref: DiffAvg: "79.98"
xref: DiffFormula: "H 1 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00696 ! phosphorylated residue

[Term]
id: MOD:01457
name: L-cysteine (Ser)
def: "A protein modification that effectively converts an L-serine residue to L-cysteine (not known as a natural, post-translational modification process)." [PubMed:1849824, PubMed:18688235]
synonym: "Cys(Ser)" EXACT PSI-MOD-label []
xref: DiffAvg: "-16.06"
xref: DiffFormula: "C 0 H 0 N 0 O 1 S -1"
xref: DiffMono: "-15.977156"
xref: Formula: "C 3 H 5 N 1 O 1 S 1"
xref: MassAvg: "103.14"
xref: MassMono: "103.009185"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00749 ! sulfur substitution for oxygen
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:02088 ! natural, standard, encoded residue substitution

[Term]
id: MOD:01458
name: alpha-amino acetylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acetyl group." [OMSSA:10, Unimod:1#N-term]
subset: PSI-MOD-slim
synonym: "N2AcRes" EXACT PSI-MOD-label []
synonym: "ntermacetyl" EXACT OMSSA-label []
xref: DiffAvg: "42.04"
xref: DiffFormula: "C 2 H 2 N 0 O 1"
xref: DiffMono: "42.010565"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:1"
is_a: MOD:00408 ! mono N-acetylated residue
is_a: MOD:01696 ! alpha-amino acylated residue

[Term]
id: MOD:01459
name: 4x(2)H labeled alpha-dimethylamino N-terminal residue
def: "A protein modification that effectively converts an N-terminal residue to an 4x(2)H labeled alpha-dimethylamino N-terminal residue." [OMSSA:190, PubMed:14670044, Unimod:199#N-term]
comment: Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction.
subset: PSI-MOD-slim
synonym: "DiMethyl-CHD2" RELATED Unimod-description []
synonym: "Dimethyl:2H(4)" RELATED PSI-MS-label []
synonym: "mod190" EXACT OMSSA-label []
xref: DiffAvg: "32.06"
xref: DiffFormula: "C 2 (2)H 4"
xref: DiffMono: "32.056407"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:199"
is_a: MOD:00552 ! 4x(2)H labeled dimethylated residue

[Term]
id: MOD:01460
name: alpha-amino methylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a methyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "N2MeRes" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00602 ! N-methylated residue

[Term]
id: MOD:01461
name: N-methylated alanine
def: "A protein modification that effectively replaces an L-alanine alpha amino hydrogen with a methyl group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00665 ! methylated alanine
is_a: MOD:01460 ! alpha-amino methylated residue

[Term]
id: MOD:01462
name: N-methylated proline
def: "A protein modification that effectively replaces an L-proline alpha imino hydrogen with a methyl group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00712 ! methylated proline
is_a: MOD:01460 ! alpha-amino methylated residue

[Term]
id: MOD:01463
name: N-methylated methionine
def: "A protein modification that effectively replaces an L-methionine alpha amino hydrogen with a methyl group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00716 ! methylated methionine
is_a: MOD:01460 ! alpha-amino methylated residue

[Term]
id: MOD:01464
name: protonated L-methionine (L-methioninium) residue
def: "A protein modification that effectively converts an L-methionine residue to an L-methioninium (protonated L-methionine)." [PubMed:18688235]
subset: PSI-MOD-slim
xref: DiffAvg: "1.01"
xref: DiffFormula: "C 0 H 1 N 0 O 0 S 0"
xref: DiffMono: "1.007276"
xref: FormalCharge: "1+"
xref: Formula: "C 5 H 11 N 1 O 1 S 1"
xref: MassAvg: "133.21"
xref: MassMono: "133.055586"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00913 ! modified L-methionine residue
is_a: MOD:01700 ! alpha-amino protonated residue

[Term]
id: MOD:01465
name: N,N,N-trimethyl-L-methionine (from L-methioninium)
def: "A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to an N6,N6,N6-trimethyl-L-methionine." [PubMed:18688235]
comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Met process (MOD:01382) accounts for both protonation and trimethylation.
subset: PSI-MOD-slim
synonym: "N2Me3Met" EXACT PSI-MOD-label []
xref: DiffAvg: "42.08"
xref: DiffFormula: "C 3 H 6 N 0 O 0 S 0"
xref: DiffMono: "42.046402"
xref: FormalCharge: "1+"
xref: Formula: "C 8 H 17 N 1 O 1 S 1"
xref: MassAvg: "175.29"
xref: MassMono: "175.102537"
xref: Origin: "MOD:001464"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:01687 ! alpha-amino trimethylated residue
relationship: derives_from MOD:01464 ! protonated L-methionine (L-methioninium) residue

[Term]
id: MOD:01466
name: menadione quinone derivative - site C
def: "modification from Unimod Chemical derivative" [PubMed:15939799, Unimod:302#K]
synonym: "Menadione" RELATED Unimod-interim []
synonym: "Menadione quinone derivative" RELATED Unimod-description []
xref: DiffAvg: "170.17"
xref: DiffFormula: "C 11 H 6 O 2"
xref: DiffMono: "170.036779"
xref: Formula: "C 14 H 11 N 1 O 3 S 1"
xref: MassAvg: "273.31"
xref: MassMono: "273.045964"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:302"
is_a: MOD:00621 ! menadione quinone derivative
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01467
name: menadione quinone derivative - site K
def: "modification from Unimod Chemical derivative" [PubMed:15939799, Unimod:302#K]
synonym: "Menadione" RELATED Unimod-interim []
synonym: "Menadione quinone derivative" RELATED Unimod-description []
xref: DiffAvg: "170.17"
xref: DiffFormula: "C 11 H 6 O 2"
xref: DiffMono: "170.036779"
xref: Formula: "C 17 H 18 N 2 O 3"
xref: MassAvg: "298.34"
xref: MassMono: "298.131742"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:302"
is_a: MOD:00621 ! menadione quinone derivative
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01468
name: L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Cys)
def: "A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process)." [PubMed:14235557, PubMed:2211698, PubMed:8052647, PubMed:9036855, RESID:AA0248#CYS, Unimod:415]
comment: This entry is for the artifactual formation of L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00253.
synonym: "2-amino-5,6-dimercapto-7-methyl-3,7,8a,9-tetrahydro-8-oxa-1,3,9,10-tetraazaanthracen-4-one guanosine dinucleotide" EXACT RESID-alternate []
synonym: "bis[8-amino-1a,2,4a,5,6,7,10-heptahydro-2-(trihydrogen diphosphate 5'-ester with guanosine)methyl-6-oxo-3,4-disulfanyl-pteridino[6,7-5,6]pyranoato-S3,S4]-selenocysteinyl-Se-molybdenum" EXACT RESID-systematic []
synonym: "formate dehydrogenase selenocysteine molybdenum cofactor" EXACT RESID-alternate []
synonym: "L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)" RELATED Unimod-description []
synonym: "L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)" EXACT RESID-name []
synonym: "molybdopterin-se" RELATED Unimod-interim []
synonym: "MolybdopterinGD+Delta:S(-1)Se(1)" RELATED PSI-MS-label []
xref: DiffAvg: "1618.93"
xref: DiffFormula: "C 40 H 47 Mo 1 N 20 O 26 P 4 S 3 Se 1"
xref: DiffMono: "1620.930226"
xref: Formula: "C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1"
xref: MassAvg: "1722.07"
xref: MassMono: "1723.939410"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:415"
is_a: MOD:00744 ! molybdenum pterin containing modification
is_a: MOD:02073 ! metal or metal cluster coordinated L-selenocysteine residue

[Term]
id: MOD:01469
name: L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Cys)
def: "A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process)." [PubMed:11372198, PubMed:12220497, RESID:AA0376#CYS]
comment: This entry is for the artifactual formation of L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00381.
xref: DiffAvg: "1738.88"
xref: DiffFormula: "C 40 H 47 N 20 O 26 P 4 S 4 Se 1 W 1"
xref: DiffMono: "1738.947820"
xref: Formula: "C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1"
xref: MassAvg: "1842.02"
xref: MassMono: "1841.957004"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00746 ! tungsten containing modified residue
is_a: MOD:00748 ! pterin modified residue
is_a: MOD:02073 ! metal or metal cluster coordinated L-selenocysteine residue

[Term]
id: MOD:01470
name: (E)-dehydrobutyrine (Thr)
def: "A protein modification that effectively converts an L-threonine residue to (E)-dehydrobutyrine." [DeltaMass:0, PubMed:1547888, PubMed:20805503, PubMed:3769923, RESID:AA0547]
subset: PSI-MOD-slim
synonym: "(2E)-2-aminobut-2-enoic acid" EXACT RESID-systematic []
synonym: "(E)-2-amino-2-butenoic acid" EXACT RESID-alternate []
synonym: "(E)-2-aminobutenoic acid" EXACT RESID-alternate []
synonym: "(E)-dehydrobutyrine" EXACT RESID-name []
synonym: "(E)dHAbu" EXACT PSI-MOD-label []
synonym: "2,3-didehydrobutyrine" EXACT RESID-alternate []
synonym: "3-methyldehydroalanine" EXACT RESID-alternate []
synonym: "alpha,beta-dehydroaminobutyric acid" EXACT RESID-alternate []
synonym: "anhydrothreonine" EXACT RESID-alternate []
synonym: "Dehydrated" RELATED Unimod-interim []
synonym: "Dehydration" RELATED Unimod-description []
synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label []
synonym: "Dhb" EXACT RESID-alternate []
synonym: "methyl-dehydroalanine" EXACT RESID-alternate []
synonym: "MOD_RES (E)-2,3-didehydrobutyrine" EXACT UniProt-feature []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 4 H 5 N 1 O 1"
xref: MassAvg: "83.09"
xref: MassMono: "83.037114"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0441
is_a: MOD:00190 ! dehydrobutyrine (Thr)

[Term]
id: MOD:01471
name: (Z)-dehydrobutyrine (Thr)
def: "A protein modification that effectively converts an L-threonine residue to (Z)-dehydrobutyrine." [DeltaMass:0, PubMed:1547888, PubMed:3769923, RESID:AA0182]
subset: PSI-MOD-slim
synonym: "(2Z)-2-aminobut-2-enoic acid" EXACT RESID-systematic []
synonym: "(Z)-2-amino-2-butenoic acid" EXACT RESID-alternate []
synonym: "(Z)-2-aminobutenoic acid" EXACT RESID-alternate []
synonym: "(Z)-dehydrobutyrine" EXACT RESID-name []
synonym: "(Z)dHAbu" EXACT PSI-MOD-label []
synonym: "2,3-didehydrobutyrine" EXACT RESID-alternate []
synonym: "3-methyldehydroalanine" EXACT RESID-alternate []
synonym: "alpha,beta-dehydroaminobutyric acid" EXACT RESID-alternate []
synonym: "anhydrothreonine" EXACT RESID-alternate []
synonym: "Dehydrated" RELATED Unimod-interim []
synonym: "Dehydration" RELATED Unimod-description []
synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label []
synonym: "Dhb" EXACT RESID-alternate []
synonym: "methyl-dehydroalanine" EXACT RESID-alternate []
synonym: "MOD_RES (Z)-2,3-didehydrobutyrine" EXACT UniProt-feature []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 4 H 5 N 1 O 1"
xref: MassAvg: "83.09"
xref: MassMono: "83.037114"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0440
is_a: MOD:00190 ! dehydrobutyrine (Thr)

[Term]
id: MOD:01472
name: reduced residue
def: "A protein modification that effectively either adds neutral hydrogen atoms (proton and electron), or removes oxygen atoms from a residue with or without the addition of hydrogen atoms." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "RedRes" EXACT PSI-MOD-label []
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:01473
name: hydrogenated residue
def: "A protein modification that effectively adds neutral hydrogen atoms (proton and electron) to a residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "HRes" EXACT PSI-MOD-label []
is_a: MOD:01472 ! reduced residue

[Term]
id: MOD:01474
name: O-[S-(carboxymethyl)phosphopantetheine]-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-[S-(carboxymethyl)phosphopantetheine]-L-serine." [PubMed:18688235]
comment: This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetic acid [JSG].
xref: DiffAvg: "398.37"
xref: DiffFormula: "C 13 H 23 N 2 O 8 P 1 S 1"
xref: DiffMono: "398.091273"
xref: Formula: "C 16 H 28 N 3 O 10 P 1 S 1"
xref: MassAvg: "485.44"
xref: MassMono: "485.123302"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:00399 ! iodoacetic acid derivatized residue
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00916 ! modified L-serine residue
relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine

[Term]
id: MOD:01475
name: O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine." [PubMed:18688235]
comment: This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetamide [JSG].
xref: DiffAvg: "397.38"
xref: DiffFormula: "C 13 H 24 N 3 O 7 P 1 S 1"
xref: DiffMono: "397.107258"
xref: Formula: "C 16 H 29 N 4 O 9 P 1 S 1"
xref: MassAvg: "484.46"
xref: MassMono: "484.139286"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:00397 ! iodoacetamide derivatized residue
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00916 ! modified L-serine residue
relationship: derives_from MOD:00159 ! O-phosphopantetheine-L-serine

[Term]
id: MOD:01476
name: 2'-fluoro-L-phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to an 2'-fluoro-L-fluorophenylalanine." [PubMed:18688235, PubMed:8172898]
synonym: "2-fluorophenylalanine" EXACT PSI-MOD-alternate []
synonym: "o-fluorophenylalanine" EXACT PSI-MOD-alternate []
synonym: "ortho-fluorophenylalanine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "17.99"
xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0"
xref: DiffMono: "17.990578"
xref: Formula: "C 9 F 1 H 8 N 1 O 1"
xref: MassAvg: "165.17"
xref: MassMono: "165.058992"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01227 ! monofluorinated L-phenylalanine

[Term]
id: MOD:01477
name: 3'-fluoro-L-phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue to an 3'-fluoro-L-fluorophenylalanine." [PubMed:18688235, PubMed:8172898]
synonym: "3-fluorophenylalanine" EXACT PSI-MOD-alternate []
synonym: "m-fluorophenylalanine" EXACT PSI-MOD-alternate []
synonym: "meta-fluorophenylalanine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "17.99"
xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0"
xref: DiffMono: "17.990578"
xref: Formula: "C 9 F 1 H 8 N 1 O 1"
xref: MassAvg: "165.17"
xref: MassMono: "165.058992"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01227 ! monofluorinated L-phenylalanine

[Term]
id: MOD:01478
name: 4'-fluoro-L-phenylalanine
def: "A protein modification that effectively converts an L-phenylalanine residue into an 4'-fluoro-L-fluorophenylalanine." [PubMed:18688235, PubMed:8172898]
synonym: "4-fluorophenylalanine" EXACT PSI-MOD-alternate []
synonym: "p-fluorophenylalanine" EXACT PSI-MOD-alternate []
synonym: "para-fluorophenylalanine" EXACT PSI-MOD-alternate []
synonym: "rho-fluorophenylalanine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "17.99"
xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0"
xref: DiffMono: "17.990578"
xref: Formula: "C 9 F 1 H 8 N 1 O 1"
xref: MassAvg: "165.17"
xref: MassMono: "165.058992"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01227 ! monofluorinated L-phenylalanine

[Term]
id: MOD:01479
name: 4'-fluoro-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue into an 4'-fluoro-L-tryptophan." [PubMed:18688235, PubMed:8172898]
synonym: "4-fluorotryptophan" EXACT PSI-MOD-alternate []
xref: DiffAvg: "17.99"
xref: DiffFormula: "F 1 H -1"
xref: DiffMono: "17.990578"
xref: Formula: "C 11 F 1 H 9 N 2 O 1"
xref: MassAvg: "204.20"
xref: MassMono: "204.069891"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01226 ! monofluorinated L-tryptophan

[Term]
id: MOD:01480
name: 5'-fluoro-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue into an 5'-fluoro-L-tryptophan." [PubMed:18688235, PubMed:8172898]
synonym: "5-fluorotryptophan" EXACT PSI-MOD-alternate []
xref: DiffAvg: "17.99"
xref: DiffFormula: "F 1 H -1"
xref: DiffMono: "17.990578"
xref: Formula: "C 11 F 1 H 9 N 2 O 1"
xref: MassAvg: "204.20"
xref: MassMono: "204.069891"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01226 ! monofluorinated L-tryptophan

[Term]
id: MOD:01481
name: 6'-fluoro-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue into an 6'-fluoro-L-tryptophan." [PubMed:18688235, PubMed:8172898]
synonym: "6-fluorotryptophan" EXACT PSI-MOD-alternate []
xref: DiffAvg: "17.99"
xref: DiffFormula: "F 1 H -1"
xref: DiffMono: "17.990578"
xref: Formula: "C 11 F 1 H 9 N 2 O 1"
xref: MassAvg: "204.20"
xref: MassMono: "204.069891"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01226 ! monofluorinated L-tryptophan

[Term]
id: MOD:01482
name: calcium containing modified residue
def: "A protein modification that effectively substitutes a calcium atom or a cluster containing calcium for hydrogen atoms, or that coordinates a calcium ion." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "CaRes" EXACT PSI-MOD-label []
is_a: MOD:00698 ! metal or metal cluster containing modified residue

[Term]
id: MOD:01483
name: O-formylated residue
def: "A protein modification that effectively replaces a residue hydroxyl group with a formyloxy group." [PubMed:18688235]
synonym: "OFoRes" EXACT PSI-MOD-label []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00493 ! formylated residue
is_a: MOD:00671 ! O-acylated residue

[Term]
id: MOD:01484
name: N6-(L-isoglutamyl)-L-lysine (Glu)
def: "A protein modification that effectively crosslinks an L-glutamic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine and the release of water." [ChEBI:21863, PubMed:19015515, RESID:AA0124#GLU]
comment: Cross-link 2. This cross-link is usually made by glutamine and releases ammonia, rather than glutamic acid and requiring the consumption of ATP.
synonym: "(2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid" EXACT RESID-alternate []
synonym: "5-glutamyl N6-lysine" EXACT RESID-alternate []
synonym: "N alpha -(gamma-Glutamyl)-lysine" EXACT DeltaMass-label []
synonym: "N(epsilon)-(gamma-glutamyl)lysine" EXACT RESID-alternate []
synonym: "N6-(L-isoglutamyl)-L-lysine" EXACT RESID-name []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 11 H 17 N 3 O 3"
xref: MassAvg: "239.27"
xref: MassMono: "239.126991"
xref: Origin: "K, E"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02045 ! crosslinked L-glutamic acid residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01630 ! N6-(L-isoglutamyl)-L-lysine

[Term]
id: MOD:01485
name: iTRAQ4plex-114 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [Unimod:532]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 114" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ114" RELATED Unimod-interim []
synonym: "iTRAQ4plex114" RELATED PSI-MS-label []
xref: DiffAvg: "144.11"
xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1"
xref: DiffMono: "144.105919"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:532"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01430 ! (18)O isotope tagged reagent
is_a: MOD:01516 ! modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da.
is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue

[Term]
id: MOD:01486
name: iTRAQ4plex-114 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [OMSSA:167, Unimod:532#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 114" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ114" RELATED Unimod-interim []
synonym: "iTRAQ114nterm" EXACT OMSSA-label []
synonym: "iTRAQ4plex114" RELATED PSI-MS-label []
xref: DiffAvg: "144.11"
xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1"
xref: DiffMono: "144.105919"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:532"
is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue
is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01487
name: iTRAQ4plex-114 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [OMSSA:168, Unimod:532#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 114" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ114" RELATED Unimod-interim []
synonym: "iTRAQ114K" EXACT OMSSA-label []
synonym: "iTRAQ4plex114" RELATED PSI-MS-label []
xref: DiffAvg: "144.11"
xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1"
xref: DiffMono: "144.105919"
xref: Formula: "(12)C 11 (13)C 2 H 24 N 4 (16)O 1 (18)O 1"
xref: MassAvg: "272.20"
xref: MassMono: "272.200882"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:532"
is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent ac ylated residue
is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01488
name: iTRAQ4plex-114 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [OMSSA:169, Unimod:532#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 114" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ114" RELATED Unimod-interim []
synonym: "iTRAQ114Y" EXACT OMSSA-label []
synonym: "iTRAQ4plex114" RELATED PSI-MS-label []
xref: DiffAvg: "144.11"
xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1"
xref: DiffMono: "144.105919"
xref: Formula: "(12)C 14 (13)C 2 H 21 N 3 (16)O 2 (18)O 1"
xref: MassAvg: "307.17"
xref: MassMono: "307.169248"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:532"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01489
name: iTRAQ4plex-114 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex114" RELATED PSI-MS-label []
xref: DiffAvg: "144.11"
xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1"
xref: DiffMono: "144.105919"
xref: Formula: "(12)C 11 (13)C 2 H 19 N 5 O 1 (18)O 1"
xref: MassAvg: "281.16"
xref: MassMono: "281.164831"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue
is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01490
name: iTRAQ4plex-114 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex114" RELATED PSI-MS-label []
xref: DiffAvg: "144.11"
xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1"
xref: DiffMono: "144.105919"
xref: Formula: "(12)C 8 (13)C 2 H 17 N 3 O 2 (18)O 1"
xref: MassAvg: "231.14"
xref: MassMono: "231.137947"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01491
name: iTRAQ4plex-114 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex114" RELATED PSI-MS-label []
xref: DiffAvg: "144.11"
xref: DiffFormula: "(12)C 5 (13)C 2 H 12 N 2 (18)O 1"
xref: DiffMono: "144.105919"
xref: Formula: "(12)C 9 (13)C 2 H 19 N 3 O 2 (18)O 1"
xref: MassAvg: "245.15"
xref: MassMono: "245.153598"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01492
name: iTRAQ4plex-115 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [Unimod:533]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ115" RELATED Unimod-interim []
synonym: "iTRAQ4plex115" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1"
xref: DiffMono: "144.099599"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:533"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01430 ! (18)O isotope tagged reagent
is_a: MOD:01516 ! modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da.
is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue

[Term]
id: MOD:01493
name: iTRAQ4plex-115 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [OMSSA:170, Unimod:533#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ115" RELATED Unimod-interim []
synonym: "iTRAQ115nterm" EXACT OMSSA-label []
synonym: "iTRAQ4plex115" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1"
xref: DiffMono: "144.099599"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:533"
is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue
is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01494
name: iTRAQ4plex-115 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [OMSSA:171, Unimod:533#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ115" RELATED Unimod-interim []
synonym: "iTRAQ115K" EXACT OMSSA-label []
synonym: "iTRAQ4plex115" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1"
xref: DiffMono: "144.099599"
xref: Formula: "(12)C 12 (13)C 1 H 24 (14)N 3 (15)N 1 (16)O 1 (18)O 1"
xref: MassAvg: "272.19"
xref: MassMono: "272.194562"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:533"
is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue
is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01495
name: iTRAQ4plex-115 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [OMSSA:172, Unimod:533#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ115" RELATED Unimod-interim []
synonym: "iTRAQ115Y" EXACT OMSSA-label []
synonym: "iTRAQ4plex115" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1"
xref: DiffMono: "144.099599"
xref: Formula: "(12)C 15 (13)C 1 H 21 (14)N 2 (15)N 1 (16)O 2 (18)O 1"
xref: MassAvg: "307.16"
xref: MassMono: "307.162928"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:533"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01496
name: iTRAQ4plex-115 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex115" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1"
xref: DiffMono: "144.099599"
xref: Formula: "(12)C 12 (13)C 1 H 19 (14)N 4 (15)N 1 (16)O 1 (18)O 1"
xref: MassAvg: "281.16"
xref: MassMono: "281.158511"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue
is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01497
name: iTRAQ4plex-115 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex115" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1"
xref: DiffMono: "144.099599"
xref: Formula: "(12)C 9 (13)C 1 H 17 N 1 (14)N 1 (15)N 1 (16)O 2 (18)O 1"
xref: MassAvg: "231.13"
xref: MassMono: "231.131628"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01498
name: iTRAQ4plex-115 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex115" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1"
xref: DiffMono: "144.099599"
xref: Formula: "(12)C 10 (13)C 1 H 19 (14)N 2 (15)N 1 (16)O 2 (18)O 1"
xref: MassAvg: "245.15"
xref: MassMono: "245.147278"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01499
name: iTRAQ4plex-116 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [Unimod:214]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ" RELATED Unimod-interim []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
synonym: "Representative mass and accurate mass for 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:214"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01517 ! modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da
is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue

[Term]
id: MOD:01500
name: iTRAQ4plex-116 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [OMSSA:173, Unimod:214#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ" RELATED Unimod-interim []
synonym: "iTRAQ116nterm" EXACT OMSSA-label []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
synonym: "Representative mass and accurate mass for 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:214"
is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue
is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01501
name: iTRAQ4plex-116 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [OMSSA:174, Unimod:214#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ" RELATED Unimod-interim []
synonym: "iTRAQ116K" EXACT OMSSA-label []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
synonym: "Representative mass and accurate mass for 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "(12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1"
xref: MassAvg: "272.20"
xref: MassMono: "272.197025"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:214"
is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue
is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01502
name: iTRAQ4plex-116 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [OMSSA:175, Unimod:214#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ" RELATED Unimod-interim []
synonym: "iTRAQ116Y" EXACT OMSSA-label []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
synonym: "Representative mass and accurate mass for 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "(12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1"
xref: MassAvg: "307.17"
xref: MassMono: "307.165391"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:214"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01503
name: iTRAQ4plex-116 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "(12)C 10 (13)C 3 H 19 N 3 (14)N 1 (15)N 1 (16)O 2"
xref: MassAvg: "281.16"
xref: MassMono: "281.160974"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue
is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01504
name: iTRAQ4plex-116 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "(12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3"
xref: MassAvg: "231.13"
xref: MassMono: "231.134091"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01505
name: iTRAQ4plex-116 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "(12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3"
xref: MassAvg: "245.15"
xref: MassMono: "245.149741"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01506
name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [Unimod:214, Unimod:889]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED Unimod-alternate []
synonym: "iTRAQ" RELATED Unimod-interim []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
synonym: "mTRAQ heavy" RELATED Unimod-description []
synonym: "Representative mass and accurate mass for 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:214"
xref: Unimod: "Unimod:889"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01517 ! modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da
is_a: MOD:01518 ! iTRAQ4plex reporter+balance reagent acylated residue
is_a: MOD:01863 ! mTRAQ reporter+balance reagent acylated residue

[Term]
id: MOD:01507
name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [OMSSA:176, OMSSA:211, Unimod:214#N-term, Unimod:889#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED Unimod-alternate []
synonym: "iTRAQ" RELATED Unimod-interim []
synonym: "iTRAQ117nterm" EXACT OMSSA-label []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
synonym: "mTRAQ heavy" RELATED Unimod-description []
synonym: "mTRAQ heavy on nterm" EXACT OMSSA-label []
synonym: "Representative mass and accurate mass for 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:214"
xref: Unimod: "Unimod:889"
is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue
is_a: MOD:01711 ! iTRAQ4plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01508
name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [OMSSA:177, OMSSA:212, Unimod:214#K, Unimod:889#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED Unimod-alternate []
synonym: "iTRAQ" RELATED Unimod-interim []
synonym: "iTRAQ117K" EXACT OMSSA-label []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
synonym: "mTRAQ heavy" RELATED Unimod-description []
synonym: "mTRAQ heavy on K" EXACT OMSSA-label []
synonym: "Representative mass and accurate mass for 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "(12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1"
xref: MassAvg: "272.20"
xref: MassMono: "272.197025"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:214"
is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue
is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01509
name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [OMSSA:178, OMSSA:213, Unimod:214#Y, Unimod:889#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED Unimod-alternate []
synonym: "iTRAQ" RELATED Unimod-interim []
synonym: "iTRAQ117Y" EXACT OMSSA-label []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
synonym: "mTRAQ heavy" RELATED Unimod-description []
synonym: "mTRAQ heavy on Y" EXACT OMSSA-label []
synonym: "Representative mass and accurate mass for 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "(12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1"
xref: MassAvg: "307.17"
xref: MassMono: "307.165391"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:214"
xref: Unimod: "Unimod:889"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01510
name: iTRAQ4plex-117 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "(12)C 10 (13)C 3 H 19 (14)N 4 (15)N 1 (16)O 2"
xref: MassAvg: "281.16"
xref: MassMono: "281.160974"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue
is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01511
name: iTRAQ4plex-117 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "(12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3"
xref: MassAvg: "231.13"
xref: MassMono: "231.134091"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01512
name: iTRAQ4plex-117 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ4plex" RELATED PSI-MS-label []
xref: DiffAvg: "144.10"
xref: DiffFormula: "(12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1"
xref: DiffMono: "144.102062"
xref: Formula: "(12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3"
xref: MassAvg: "245.15"
xref: MassMono: "245.149741"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue
is_a: MOD:01713 ! iTRAQ4plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01513
name: modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.1 Da
def: "Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.1 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00538 ! protein modification categorized by isobaric sets

[Term]
id: MOD:01514
name: modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da
def: "Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.01 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01513 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.1 Da

[Term]
id: MOD:01515
name: modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da
def: "Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.000001 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01514 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da

[Term]
id: MOD:01516
name: modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da.
def: "Modifications that have monoisotopic mass differences from their respective origins of 144.099-144.106 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01514 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da

[Term]
id: MOD:01517
name: modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da
def: "Modifications that have monoisotopic mass differences from their respective origins of 144.102062 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da
is_a: MOD:01516 ! modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da.

[Term]
id: MOD:01518
name: iTRAQ4plex reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups." [Unimod:214]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:214"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue
is_a: MOD:01705 ! isotope tagged reagent acylated residue

[Term]
id: MOD:01519
name: reporter fragment
def: "A distinct molecular entity produced from a protein or a protein modification as the result of a fragmentation process." [PubMed:18688235]
comment: The reporter fragment is either itself a modification consisting of atoms derived from the original amino acid residues, or its detection can be taken as evidence that particular modified residues had been present.
subset: PSI-MOD-slim
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:01520
name: modification reporter fragment
def: "A distinct molecular entity produced as the result of a fragmentation process performed on a particular modified residue." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01519 ! reporter fragment

[Term]
id: MOD:01521
name: iTRAQ4plex reporter fragment
def: "A protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01520 ! modification reporter fragment

[Term]
id: MOD:01522
name: iTRAQ4plex-114 reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 114 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 2"
xref: MassAvg: "114.11"
xref: MassMono: "114.110680"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01521 ! iTRAQ4plex reporter fragment
relationship: derives_from MOD:01485 ! iTRAQ4plex-114 reporter+balance reagent acylated residue

[Term]
id: MOD:01523
name: iTRAQ4plex-115 reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 115 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1"
xref: MassAvg: "115.11"
xref: MassMono: "115.107715"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01521 ! iTRAQ4plex reporter fragment
relationship: derives_from MOD:01492 ! iTRAQ4plex-115 reporter+balance reagent acylated residue

[Term]
id: MOD:01524
name: iTRAQ4plex-116 reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 116 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1"
xref: MassAvg: "116.11"
xref: MassMono: "116.111069"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01521 ! iTRAQ4plex reporter fragment
relationship: derives_from MOD:01499 ! iTRAQ4plex-116 reporter+balance reagent acylated residue

[Term]
id: MOD:01525
name: iTRAQ4plex-117, mTRAQ heavy, reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 117 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1"
xref: MassAvg: "117.11"
xref: MassMono: "117.114424"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01521 ! iTRAQ4plex reporter fragment
is_a: MOD:01870 ! mTRAQ reporter fragment
relationship: derives_from MOD:01506 ! iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue

[Term]
id: MOD:01526
name: iTRAQ8plex reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups." [Unimod:730]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue
is_a: MOD:01705 ! isotope tagged reagent acylated residue

[Term]
id: MOD:01527
name: residue reporter fragment
def: "A distinct molecular entity produced from a particular amino acid residue as the result of a fragmentation process." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01519 ! reporter fragment

[Term]
id: MOD:01528
name: iTRAQ8plex-113 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [Unimod:730]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue
is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da

[Term]
id: MOD:01529
name: iTRAQ8plex-113 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [Unimod:730#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:730"
is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue
is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01530
name: iTRAQ8plex-113 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [Unimod:730#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4"
xref: MassAvg: "432.30"
xref: MassMono: "432.300322"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01531
name: iTRAQ8plex-113 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [Unimod:730#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "467.27"
xref: MassMono: "467.268688"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01532
name: iTRAQ8plex-113 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4"
xref: MassAvg: "441.26"
xref: MassMono: "441.264271"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01533
name: iTRAQ8plex-113 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "391.24"
xref: MassMono: "391.237388"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01534
name: iTRAQ8plex-113 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "405.25"
xref: MassMono: "405.253038"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01535
name: iTRAQ8plex-114 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [Unimod:730]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue
is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da

[Term]
id: MOD:01536
name: iTRAQ8plex-114 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [Unimod:730#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:730"
is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue
is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01537
name: iTRAQ8plex-114 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [Unimod:730#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4"
xref: MassAvg: "432.30"
xref: MassMono: "432.300322"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01538
name: iTRAQ8plex-114 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [Unimod:730#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "467.27"
xref: MassMono: "467.268688"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01539
name: iTRAQ8plex-114 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4"
xref: MassAvg: "441.26"
xref: MassMono: "441.264271"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01540
name: iTRAQ8plex-114 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "391.24"
xref: MassMono: "391.237388"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01541
name: iTRAQ8plex-114 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "405.25"
xref: MassMono: "405.253038"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01542
name: iTRAQ8plex-115 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [Unimod:731]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue
is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da

[Term]
id: MOD:01543
name: iTRAQ8plex-115 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [Unimod:731#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:731"
is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue
is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01544
name: iTRAQ8plex-115 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [Unimod:731#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4"
xref: MassAvg: "432.29"
xref: MassMono: "432.294002"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01545
name: iTRAQ8plex-115 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [Unimod:731#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "467.26"
xref: MassMono: "467.262368"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01546
name: iTRAQ8plex-115 reporter+balance reagent N'-derivatized histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4"
xref: MassAvg: "441.26"
xref: MassMono: "441.257951"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01547
name: iTRAQ8plex-115 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "391.23"
xref: MassMono: "391.231068"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01548
name: iTRAQ8plex-115 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "405.25"
xref: MassMono: "405.246718"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01549
name: iTRAQ8plex-116 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [Unimod:730]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue
is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da

[Term]
id: MOD:01550
name: iTRAQ8plex-116 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [Unimod:730#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:730"
is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue
is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01551
name: iTRAQ8plex-116 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [Unimod:730#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4"
xref: MassAvg: "432.30"
xref: MassMono: "432.300322"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01552
name: iTRAQ8plex-116 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [Unimod:730#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "467.27"
xref: MassMono: "467.268688"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01553
name: iTRAQ8plex-116 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4"
xref: MassAvg: "441.26"
xref: MassMono: "441.264271"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01554
name: iTRAQ8plex-116 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "391.24"
xref: MassMono: "391.237388"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01555
name: iTRAQ8plex-116 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "405.25"
xref: MassMono: "405.253038"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01556
name: iTRAQ8plex-117 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [Unimod:730]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue
is_a: MOD:01591 ! modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da

[Term]
id: MOD:01557
name: iTRAQ8plex-117 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [Unimod:730#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:730"
is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue
is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01558
name: iTRAQ8plex-117 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [Unimod:730#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4"
xref: MassAvg: "432.30"
xref: MassMono: "432.300322"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01559
name: iTRAQ8plex-117 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [Unimod:730#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex" RELATED Unimod-interim []
synonym: "iTRAQ8plex:13C(7)15N(1)" RELATED Unimod-alternate []
synonym: "Representative mass and accurate mass for 113, 114, 116 & 117" RELATED Unimod-description []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "467.27"
xref: MassMono: "467.268688"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:730"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01560
name: iTRAQ8plex-117 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4"
xref: MassAvg: "441.26"
xref: MassMono: "441.264271"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01561
name: iTRAQ8plex-117 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "391.24"
xref: MassMono: "391.237388"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01562
name: iTRAQ8plex-117 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.21"
xref: DiffFormula: "(12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3"
xref: DiffMono: "304.205359"
xref: Formula: "(12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5"
xref: MassAvg: "405.25"
xref: MassMono: "405.253038"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01563
name: iTRAQ8plex-118 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [Unimod:731]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue
is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da

[Term]
id: MOD:01564
name: iTRAQ8plex-118 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [Unimod:731#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:731"
is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue
is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01565
name: iTRAQ8plex-118 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [Unimod:731#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4"
xref: MassAvg: "432.29"
xref: MassMono: "432.294002"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01566
name: iTRAQ8plex-118 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [Unimod:731#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "467.26"
xref: MassMono: "467.262368"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01567
name: iTRAQ8plex-118 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4"
xref: MassAvg: "441.26"
xref: MassMono: "441.257951"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01568
name: iTRAQ8plex-118 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "391.23"
xref: MassMono: "391.231068"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01569
name: iTRAQ8plex-118 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "405.25"
xref: MassMono: "405.246718"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01570
name: iTRAQ8plex-119 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [Unimod:731]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue
is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da

[Term]
id: MOD:01571
name: iTRAQ8plex-119 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [Unimod:731#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:731"
is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue
is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01572
name: iTRAQ8plex-119 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [Unimod:731#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4"
xref: MassAvg: "432.29"
xref: MassMono: "432.294002"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01573
name: iTRAQ8plex-119 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [Unimod:731#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "467.26"
xref: MassMono: "467.262368"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01574
name: iTRAQ8plex-119 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4"
xref: MassAvg: "441.26"
xref: MassMono: "441.257951"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01575
name: iTRAQ8plex-119 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "391.23"
xref: MassMono: "391.231068"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01576
name: iTRAQ8plex-119 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "405.25"
xref: MassMono: "405.246718"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01577
name: iTRAQ8plex-121 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [Unimod:731]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01526 ! iTRAQ8plex reporter+balance reagent acylated residue
is_a: MOD:01584 ! modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da

[Term]
id: MOD:01578
name: iTRAQ8plex-121 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [Unimod:731#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:731"
is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue
is_a: MOD:01712 ! iTRAQ8plex reporter+balance reagent acylated N-terminal

[Term]
id: MOD:01579
name: iTRAQ8plex-121 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [Unimod:731#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4"
xref: MassAvg: "432.29"
xref: MassMono: "432.294002"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01580
name: iTRAQ8plex-121 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [Unimod:731#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Accurate mass for 115, 118, 119 & 121" RELATED Unimod-description []
synonym: "Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry" RELATED Unimod-alternate []
synonym: "iTRAQ8plex:13C(6)15N(2)" RELATED Unimod-interim []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "467.26"
xref: MassMono: "467.262368"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:731"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01581
name: iTRAQ8plex-121 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4"
xref: MassAvg: "441.26"
xref: MassMono: "441.257951"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01582
name: iTRAQ8plex-121 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "391.23"
xref: MassMono: "391.231068"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01583
name: iTRAQ8plex-121 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.20"
xref: DiffFormula: "(12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3"
xref: DiffMono: "304.199039"
xref: Formula: "(12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5"
xref: MassAvg: "405.25"
xref: MassMono: "405.246718"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue
is_a: MOD:01714 ! iTRAQ8plex reporter+balance reagent O-acylated residue

[Term]
id: MOD:01584
name: modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da
def: "Modifications that have monoisotopic mass differences from their respective origins of 304.199039 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da
is_a: MOD:01592 ! modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da

[Term]
id: MOD:01585
name: O-glycyl-L-serine
def: "A protein modification that effectively crosslinks an L-serine residue and a glycine residue by an ester bond to form O-glycyl-L-serine." [PubMed:17502423, RESID:AA0495]
comment: Cross-link 2.
synonym: "(2S)-2-amino-3-[(aminoacetyl)oxy]propanoic acid" EXACT RESID-systematic []
synonym: "O-(glycyl)-L-serine" EXACT RESID-name []
synonym: "O3-(aminoacetyl)serine" EXACT RESID-alternate []
synonym: "serine glycinate ester" EXACT RESID-alternate []
synonym: "CROSSLNK Glycyl serine ester (Ser-Gly) (interchain with G-...)" EXACT UniProt-feature []
synonym: "CROSSLNK Glycyl serine ester (Gly-Ser) (interchain with S-...)" EXACT UniProt-feature []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 5 H 7 N 2 O 3"
xref: MassAvg: "143.12"
xref: MassMono: "143.045667"
xref: Origin: "G, S"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0422
is_a: MOD:00885 ! ester crosslinked residues
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01586
name: O-glycyl-L-threonine
def: "A protein modification that effectively crosslinks an L-threonine residue and a glycine residue by an ester bond to form O-glycyl-L-threonine." [PubMed:17502423, RESID:AA0496]
comment: Cross-link 2.
synonym: "(2S,3R)-2-amino-3-[(aminoacetyl)oxy]butanoic acid" EXACT RESID-systematic []
synonym: "O-(glycyl)-L-threonine" EXACT RESID-name []
synonym: "O3-(2-aminoacetyl)threonine" EXACT RESID-alternate []
synonym: "threonine glycinate ester" EXACT RESID-alternate []
synonym: "CROSSLNK Glycyl threonine ester (Thr-Gly) (interchain with G-...)" EXACT UniProt-feature []
synonym: "CROSSLNK Glycyl threonine ester (Gly-Thr) (interchain with T-...)" EXACT UniProt-feature []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 6 H 9 N 2 O 3"
xref: MassAvg: "157.15"
xref: MassMono: "157.061317"
xref: Origin: "G, T"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0423
is_a: MOD:00885 ! ester crosslinked residues
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01587
name: O-(2-aminoethylphosphoryl)-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-(2-aminoethylphosphoryl)-L-serine." [PubMed:15249686, PubMed:16825186, PubMed:16949362, RESID:AA0497]
synonym: "(2S)-2-amino-3-([(2-aminoethoxy)(hydroxy)phosphoryl]oxy)propanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES O-(2-aminoethylphosphoryl)serine" EXACT UniProt-feature []
synonym: "O-(2-aminoethylphosphoryl)-L-serine" EXACT RESID-name []
synonym: "O3-(2-aminoethylphosphoryl)-L-serine" EXACT RESID-alternate []
synonym: "O3-(phosphoethanolamine)-L-serine" EXACT RESID-alternate []
synonym: "serine ethanolamine phosphate" EXACT RESID-alternate []
synonym: "serine ethanolamine phosphodiester" EXACT RESID-alternate []
xref: DiffAvg: "123.05"
xref: DiffFormula: "C 2 H 6 N 1 O 3 P 1"
xref: DiffMono: "123.008530"
xref: Formula: "C 5 H 11 N 2 O 5 P 1"
xref: MassAvg: "210.13"
xref: MassMono: "210.040558"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0399
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01588
name: O-cholinephosphoryl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-cholinephosphoryl-L-serine." [PubMed:15249686, PubMed:16825186, PubMed:16949362, RESID:AA0498]
synonym: "2-[([(2S)-2-amino-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanaminium" EXACT RESID-systematic []
synonym: "2-[([(2S)-2-azanyl-2-carboxyethoxy][hydroxy]phosphoryl)oxy]-N,N,N-trimethylethanazanium" EXACT RESID-alternate []
synonym: "MOD_RES O-(2-cholinephosphoryl)serine" EXACT UniProt-feature []
synonym: "O-cholinephosphoryl-L-serine" EXACT RESID-name []
synonym: "O3-[(2-[trimethylammonio]ethyl)phosphoryl]-L-serine" EXACT RESID-alternate []
synonym: "O3-phosphocholine-L-serine" EXACT RESID-alternate []
synonym: "serine choline phosphate" EXACT RESID-alternate []
synonym: "serine choline phosphodiester" EXACT RESID-alternate []
xref: DiffAvg: "166.14"
xref: DiffFormula: "C 5 H 13 N 1 O 3 P 1"
xref: DiffMono: "166.062756"
xref: FormalCharge: "1+"
xref: Formula: "C 8 H 18 N 2 O 5 P 1"
xref: MassAvg: "253.21"
xref: MassMono: "253.094785"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0400
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01589
name: O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine." [PubMed:15249686, PubMed:16949362, RESID:AA0499]
synonym: "(2S)-2-amino-3-[(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)oxy]propanoic acid" EXACT RESID-systematic []
synonym: "DADDGlc" EXACT RESID-alternate []
synonym: "O-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate []
synonym: "O-(2,4-diacetamido-2,4-dideoxy-D-glucosyl)-L-serine" EXACT RESID-name []
synonym: "O-[2,4-bis(acetylamino)]glucosyl-L-serine" EXACT RESID-alternate []
synonym: "O-seryl-beta-2,4-bis(acetylamino)glucoside" EXACT RESID-alternate []
synonym: "O3-(2,4-diacetamido-2,4-dideoxy-beta-D-glucopyranosyl)-L-serine" EXACT RESID-alternate []
synonym: "CARBOHYD O-linked (DADDGlc) serine" EXACT UniProt-feature []
xref: DiffAvg: "244.25"
xref: DiffFormula: "C 10 H 16 N 2 O 5"
xref: DiffMono: "244.105922"
xref: Formula: "C 13 H 21 N 3 O 7"
xref: MassAvg: "331.33"
xref: MassMono: "331.137950"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0547
is_a: MOD:00002 ! O-glycosyl-L-serine

[Term]
id: MOD:01590
name: 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan." [ChEBI:52950, PubMed:18323630, RESID:AA0500]
synonym: "(2S,3aR,8aS)-3a-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid" EXACT RESID-systematic []
synonym: "3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan" EXACT RESID-name []
synonym: "LIPID 3'-farnesyl-2',N2-cyclotryptophan" EXACT UniProt-feature []
xref: DiffAvg: "204.36"
xref: DiffFormula: "C 15 H 24 N 0 O 0"
xref: DiffMono: "204.187801"
xref: Formula: "C 26 H 34 N 2 O 1"
xref: MassAvg: "390.57"
xref: MassMono: "390.267114"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00437 ! farnesylated residue
is_a: MOD:00601 ! cyclized residue
is_a: MOD:01115 ! isoprenylated tryptophan

[Term]
id: MOD:01591
name: modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da
def: "Modifications that have monoisotopic mass differences from their respective origins of 304.205359 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da
is_a: MOD:01592 ! modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da

[Term]
id: MOD:01592
name: modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da
def: "Modifications that have monoisotopic mass differences from their respective origins of 304.199-304.206 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01514 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da

[Term]
id: MOD:01593
name: iTRAQ8plex reporter fragment
def: "A protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
is_a: MOD:01520 ! modification reporter fragment

[Term]
id: MOD:01594
name: iTRAQ8plex-113 reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-113 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 6 H 13 (14)N 2"
xref: MassAvg: "113.11"
xref: MassMono: "113.107325"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01593 ! iTRAQ8plex reporter fragment
relationship: derives_from MOD:01528 ! iTRAQ8plex-113 reporter+balance reagent acylated residue

[Term]
id: MOD:01595
name: iTRAQ8plex-114 reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-114 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 2"
xref: MassAvg: "114.11"
xref: MassMono: "114.110680"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01593 ! iTRAQ8plex reporter fragment
relationship: derives_from MOD:01535 ! iTRAQ8plex-114 reporter+balance reagent acylated residue

[Term]
id: MOD:01596
name: iTRAQ8plex-115 reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-115 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1"
xref: MassAvg: "115.11"
xref: MassMono: "115.107715"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01593 ! iTRAQ8plex reporter fragment
relationship: derives_from MOD:01542 ! iTRAQ8plex-115 reporter+balance reagent acylated residue

[Term]
id: MOD:01597
name: iTRAQ8plex-116 reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-116 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1"
xref: MassAvg: "116.11"
xref: MassMono: "116.111069"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01593 ! iTRAQ8plex reporter fragment
relationship: derives_from MOD:01549 ! iTRAQ8plex-116 reporter+balance reagent acylated residue

[Term]
id: MOD:01598
name: iTRAQ8plex-117 reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-117 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1"
xref: MassAvg: "117.11"
xref: MassMono: "117.114424"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01593 ! iTRAQ8plex reporter fragment
relationship: derives_from MOD:01556 ! iTRAQ8plex-117 reporter+balance reagent acylated residue

[Term]
id: MOD:01599
name: iTRAQ8plex-118 reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-118 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 3 (13)C 3 H 13 (15)N 2"
xref: MassAvg: "118.11"
xref: MassMono: "118.111459"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01593 ! iTRAQ8plex reporter fragment
relationship: derives_from MOD:01563 ! iTRAQ8plex-118 reporter+balance reagent acylated residue

[Term]
id: MOD:01600
name: iTRAQ8plex-119 reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-119 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 2 (13)C 4 H 13 (15)N 2"
xref: MassAvg: "119.11"
xref: MassMono: "119.114814"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01593 ! iTRAQ8plex reporter fragment
relationship: derives_from MOD:01570 ! iTRAQ8plex-119 reporter+balance reagent acylated residue

[Term]
id: MOD:01601
name: iTRAQ8plex-121 reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-121 reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(13)C 6 H 13 (15)N 2"
xref: MassAvg: "121.12"
xref: MassMono: "121.121524"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01593 ! iTRAQ8plex reporter fragment
relationship: derives_from MOD:01577 ! iTRAQ8plex-121 reporter+balance reagent acylated residue

[Term]
id: MOD:01602
name: S-(L-lysyl)-L-methionine sulfilimine
def: "A protein modification that effectively converts an L-lysine residue, and an L-methionine residue to S-(L-lysyl)-L-methionine sulfilimine." [PubMed:12011424, PubMed:15951440, PubMed:19729652, RESID:AA0501]
comment: Cross-link 2.
synonym: "(2S)-2-amino-6-([(E)-[(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "(E)-N6-([(3S)-3-amino-3-carboxypropyl](methyl)-lambda(4)-sulfanylidene)-L-lysine" EXACT RESID-alternate []
synonym: "S-(L-lysyl)-L-methionine sulfilimine" EXACT RESID-name []
synonym: "S-lysyl-methionine" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 11 H 19 N 3 O 2 S 1"
xref: MassAvg: "257.35"
xref: MassMono: "257.119798"
xref: Origin: "K, M"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0401
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:02052 ! crosslinked L-methionine residue

[Term]
id: MOD:01603
name: 2x(15)N labeled L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 2x(15)N labeled L-lysine." [PubMed:18688235, URL:http\://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=609021|ALDRICH&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC&lang=en_US0.000000E+000]
subset: PSI-MOD-slim
xref: DiffAvg: "1.99"
xref: DiffFormula: "(14)N -2 (15)N 2"
xref: DiffMono: "1.994070"
xref: Formula: "C 6 H 12 (15)N 2 O 1"
xref: MassAvg: "130.09"
xref: MassMono: "130.089033"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:995"
is_a: MOD:00843 ! (15)N labeled residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01604
name: 4x(15)N labeled L-arginine
def: "A protein modification that effectively converts an L-arginine residue to 4x(15)N labeled L-arginine." [PubMed:18688235, URL:http\://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=600113|ALDRICH&N5=SEARCH_CONCAT_PNO|BRAND_KEY&F=SPEC&lang=en_US0.000000E+000]
subset: PSI-MOD-slim
xref: DiffAvg: "3.99"
xref: DiffFormula: "(14)N -4 (15)N 4"
xref: DiffMono: "3.988140"
xref: Formula: "C 6 H 12 (15)N 4 O 1"
xref: MassAvg: "160.09"
xref: MassMono: "160.089251"
xref: Origin: "R"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00843 ! (15)N labeled residue
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:01605
name: 5-glutamyl 2-aminoadipic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic acid." [PubMed:19620981, RESID:AA0502, ChEBI:78503]
synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanedioic acid" EXACT RESID-systematic []
synonym: "5-glutamyl 2-aminoadipic acid" EXACT RESID-name []
synonym: "MOD_RES 5-glutamyl 2-aminoadipic acid" EXACT UniProt-feature []
synonym: "N2-(gamma-glutamyl)-2-aminoadipic acid" EXACT RESID-alternate []
synonym: "N2-(isoglutamyl)-2-aminoadipic acid" EXACT RESID-alternate []
xref: DiffAvg: "143.14"
xref: DiffFormula: "C 6 H 9 N 1 O 3"
xref: DiffMono: "143.058243"
xref: Formula: "C 11 H 16 N 2 O 6"
xref: MassAvg: "272.26"
xref: MassMono: "272.100836"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0406
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:01606
name: 5-glutamyl 2-aminoadipic 6-phosphoric anhydride
def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic 6-phosphoric anhydride." [PubMed:19620981, RESID:AA0503]
synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxo-6-(phosphonooxy)hexanoic acid" EXACT RESID-systematic []
synonym: "5-glutamyl 2-aminoadipic 6-phosphoric anhydride" EXACT RESID-name []
xref: DiffAvg: "223.12"
xref: DiffFormula: "C 6 H 10 N 1 O 6 P 1"
xref: DiffMono: "223.024574"
xref: Formula: "C 11 H 17 N 2 O 9 P 1"
xref: MassAvg: "352.24"
xref: MassMono: "352.067167"
xref: Origin: "E"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:01607
name: 5-glutamyl allysine
def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl allysine." [PubMed:19620981, RESID:AA0504]
synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-6-oxohexanoic acid" EXACT RESID-systematic []
synonym: "2-(5-glutamyl)amino-6-oxohexanoic acid" EXACT RESID-alternate []
synonym: "5-glutamyl allysine" EXACT RESID-name []
synonym: "alpha-(gamma-glutamyl)allysine" EXACT RESID-alternate []
synonym: "N2-(gamma-glutamyl)allysine" EXACT RESID-alternate []
synonym: "N2-(isoglutamyl)allysine" EXACT RESID-alternate []
xref: DiffAvg: "127.14"
xref: DiffFormula: "C 6 H 9 N 1 O 2"
xref: DiffMono: "127.063329"
xref: Formula: "C 11 H 16 N 2 O 5"
xref: MassAvg: "256.26"
xref: MassMono: "256.105922"
xref: Origin: "E"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:01608
name: N2-(L-isoglutamyl)-L-lysine
def: "A protein modification that effectively converts an L-glutamic acid residue to N2-(L-isoglutamyl)-L-lysine. This is not an isopeptide cross-link." [PubMed:19620981, RESID:AA0505]
synonym: "(2S)-6-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "5-glutamyl N2-lysine" EXACT RESID-alternate []
synonym: "alpha-(gamma-glutamyl)lysine" EXACT RESID-alternate []
synonym: "gamma-glutamyl N2-lysine" EXACT RESID-alternate []
synonym: "MOD_RES 5-glutamyl N2-lysine" EXACT UniProt-feature []
synonym: "N2-(gamma-glutamyl)lysine" EXACT RESID-alternate []
synonym: "N2-(L-isoglutamyl)-L-lysine" EXACT RESID-name []
xref: DiffAvg: "128.18"
xref: DiffFormula: "C 6 H 12 N 2 O 1"
xref: DiffMono: "128.094963"
xref: Formula: "C 11 H 19 N 3 O 4"
xref: MassAvg: "257.29"
xref: MassMono: "257.137556"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0407
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:01609
name: 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan." [PubMed:19584055, RESID:AA0506]
synonym: "(2S)-2-amino-3-[7-hydroxy-2-(alpha-D-mannopyranosyl)-1H-indol-3-yl]propanoic acid" EXACT RESID-systematic []
synonym: "7'-hydroxy-2'-alpha-mannosyl-L-tryptophan" EXACT RESID-name []
synonym: "CARBOHYD C-linked (Man) hydroxytryptophan" EXACT UniProt-feature []
xref: DiffAvg: "178.14"
xref: DiffFormula: "C 6 H 10 N 0 O 6"
xref: DiffMono: "178.047738"
xref: Formula: "C 17 H 20 N 2 O 7"
xref: MassAvg: "364.35"
xref: MassMono: "364.127051"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0504
is_a: MOD:00918 ! modified L-tryptophan residue
relationship: has_functional_parent MOD:00222 ! 2'-alpha-mannosyl-L-tryptophan
relationship: has_functional_parent MOD:01664 ! 7'-hydroxy-L-tryptophan

[Term]
id: MOD:01610
name: L-threonine methyl ester
def: "A protein modification that effectively converts an L-threonine residue to L-threonine methyl ester." [PubMed:19745839, RESID:AA0507]
synonym: "L-threonine methyl ester" EXACT RESID-name []
synonym: "methyl (2S,3R)-2-amino-3-hydroxybutanoate" EXACT RESID-systematic []
synonym: "methyl L-threoninate" EXACT RESID-alternate []
synonym: "MOD_RES Threonine methyl ester" EXACT UniProt-feature []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 5 H 10 N 1 O 3"
xref: MassAvg: "132.14"
xref: MassMono: "132.066068"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0412
is_a: MOD:01689 ! alpha-carboxyl methylated residue
is_a: MOD:01803 ! O-methylated threonine

[Term]
id: MOD:01611
name: 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN
def: "A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN." [PubMed:17935335, RESID:AA0508]
comment: Cross-link 2.
subset: PSI-MOD-slim
synonym: "6-((R)-2-amino-2-carboxyethyl)sulfanyl-8alpha-[4-((S)-2-amino-2-carboxyethyl)imidazol-3-yl]-riboflavin 5'-trihydrogen phosphate" EXACT RESID-systematic []
synonym: "6-(S-cysteinyl)-8alpha-(N(delta)-histidyl)-FMN" EXACT RESID-alternate []
synonym: "6-(S-cysteinyl)-8alpha-(N(pi)-histidyl)-FMN" EXACT RESID-alternate []
synonym: "6-(S-cysteinyl)-8alpha-(N3'-histidyl)-FMN" EXACT RESID-alternate []
synonym: "6-(S-cysteinyl)-8alpha-(pros-histidyl)-FMN" EXACT RESID-alternate []
synonym: "6-(S-L-cysteinyl)-8alpha-(N3'-L-histidino)-FMN" EXACT RESID-name []
synonym: "BINDING FMN (covalent; via 2 links)" EXACT UniProt-feature []
synonym: "BINDING FMN (covalent; via 2 links, pros nitrogen)" EXACT UniProt-feature []
xref: DiffAvg: "452.32"
xref: DiffFormula: "C 17 H 17 N 4 O 9 P 1 S 0"
xref: DiffMono: "452.073315"
xref: Formula: "C 26 H 29 N 8 O 11 P 1 S 1"
xref: MassAvg: "692.60"
xref: MassMono: "692.141411"
xref: Origin: "C, H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02048 ! crosslinked L-histidine residue
is_a: MOD:01621 ! flavin crosslinked residues

[Term]
id: MOD:01612
name: 3'-iodo-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to 3'-iodo-L-tyrosine." [ChEBI:27847, PubMed:8995307, RESID:AA0509]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid" EXACT RESID-systematic []
synonym: "3'-iodo-L-tyrosine" EXACT RESID-name []
synonym: "3-iodo-L-tyrosine" EXACT RESID-alternate []
synonym: "3-iodotyrosine" EXACT RESID-alternate []
synonym: "4-hydroxy-3-iodo-phenylalanine" EXACT RESID-alternate []
synonym: "MIT" EXACT RESID-alternate []
synonym: "MOD_RES Iodotyrosine" EXACT UniProt-feature []
xref: DiffAvg: "125.90"
xref: DiffFormula: "C 0 H -1 I 1 N 0 O 0"
xref: DiffMono: "125.896648"
xref: Formula: "C 9 H 8 I 1 N 1 O 2"
xref: MassAvg: "289.07"
xref: MassMono: "288.959976"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0411
is_a: MOD:01228 ! monoiodinated tyrosine

[Term]
id: MOD:01613
name: 3',5'-diiodo-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to 3',5'-diiodo-L-tyrosine." [ChEBI:15768, PubMed:8995307, RESID:AA0510]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid" EXACT RESID-systematic []
synonym: "3',5'-diiodo-L-tyrosine" EXACT RESID-name []
synonym: "3,5-diiodo-L-tyrosine" EXACT RESID-alternate []
synonym: "3,5-diiodotyrosine" EXACT RESID-alternate []
synonym: "DIT" EXACT RESID-alternate []
synonym: "iodogorgoic acid" EXACT RESID-alternate []
synonym: "MOD_RES Diiodotyrosine" EXACT UniProt-feature []
xref: DiffAvg: "251.79"
xref: DiffFormula: "C 0 H -2 I 2 N 0 O 0"
xref: DiffMono: "251.793295"
xref: Formula: "C 9 H 7 I 2 N 1 O 2"
xref: MassAvg: "414.97"
xref: MassMono: "414.856624"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0408
is_a: MOD:01140 ! diiodinated tyrosine

[Term]
id: MOD:01614
name: glycyl phospho-5'-adenosine
def: "A protein modification that effectively converts a glycine residue to glycyl phospho-5'-adenosine." [PubMed:16388576, PubMed:9632726, RESID:AA0511]
synonym: "(2-aminoacetyl)oxy-([(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy)phosphinic acid" EXACT RESID-alternate []
synonym: "([(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl)-2-aminoethanoate" EXACT RESID-alternate []
synonym: "5'-adenylic-glyinate" EXACT RESID-alternate []
synonym: "aminoacetyl [5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl hydrogen phosphate" EXACT RESID-systematic []
synonym: "glycine monoanhydride with 5'-adenylic acid" EXACT RESID-alternate []
synonym: "glycyl 5'-adenylate" EXACT RESID-alternate []
synonym: "glycyl adenosine-5'-phosphate" EXACT RESID-alternate []
synonym: "glycyl phospho-5'-adenosine" EXACT RESID-name []
synonym: "glycyladenylate" EXACT RESID-alternate []
synonym: "MOD_RES Glycyl adenylate" EXACT UniProt-feature []
xref: DiffAvg: "329.21"
xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1"
xref: DiffMono: "329.052520"
xref: Formula: "C 12 H 16 N 6 O 8 P 1"
xref: MassAvg: "403.27"
xref: MassMono: "403.076723"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0409
is_a: MOD:00908 ! modified glycine residue
is_a: MOD:01165 ! adenylated residue

[Term]
id: MOD:01615
name: glycyl cysteine dithioester
def: "A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a dithioester bond to form glycyl cysteine dithioester." [PubMed:11438688, PubMed:16388576, RESID:AA0512]
comment: Cross-link 2.
synonym: "(2R)-2-amino-3-[(aminoacetyl)disulfanyl]propanoic acid" EXACT RESID-systematic []
synonym: "2-(glycyldithio)alanine" EXACT RESID-alternate []
synonym: "glycyl cysteine dithioester" EXACT RESID-name []
synonym: "S-glycyl cysteine persulfide" EXACT RESID-alternate []
synonym: "S-glycyl thiocysteine" EXACT RESID-alternate []
synonym: "thioglycine cysteine disulfide" EXACT RESID-alternate []
xref: DiffAvg: "14.05"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 1"
xref: DiffMono: "13.961506"
xref: Formula: "C 5 H 7 N 2 O 2 S 2"
xref: MassAvg: "191.24"
xref: MassMono: "190.994894"
xref: Origin: "C, G"
xref: Source: "hypothetical"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0410
is_a: MOD:00395 ! thioester crosslinked residues
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01616
name: trithiocystine
def: "A protein modification that effectively cross-links two L-cysteine residues and adds three sulfur atoms to form trithiocystine." [PubMed:19438211, RESID:AA0513]
comment: Cross-link 2.
synonym: "(2R,2'R)-3,3'-pentasulfane-1,5-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic []
synonym: "3,3'-pentathiobisalanine" EXACT RESID-alternate []
synonym: "bis(2-amino-2-carboxyethyl)pentasulfide" EXACT RESID-alternate []
synonym: "trithiocystine" EXACT RESID-name []
xref: DiffAvg: "94.16"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 3"
xref: DiffMono: "93.900563"
xref: Formula: "C 6 H 8 N 2 O 2 S 5"
xref: MassAvg: "300.44"
xref: MassMono: "299.918933"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0417
is_a: MOD:01620 ! polysulfide crosslinked residues

[Term]
id: MOD:01617
name: O-(6-phosphomannosyl)-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-(6-phosphomannosyl)-L-threonine." [PubMed:20044576, RESID:AA0514]
synonym: "(2S,3R)-2-amino-3-[6-phosphonooxy-alpha-D-mannopyranosyloxy]butanoic acid" EXACT RESID-systematic []
synonym: "O-(6-phosphomannosyl)-L-threonine" EXACT RESID-name []
synonym: "O3-(6-phosphomannosyl)threonine" EXACT RESID-alternate []
synonym: "CARBOHYD O-linked (Man6P) threonine" EXACT UniProt-feature []
xref: DiffAvg: "242.12"
xref: DiffFormula: "C 6 H 11 N 0 O 8 P 1"
xref: DiffMono: "242.019154"
xref: Formula: "C 10 H 18 N 1 O 10 P 1"
xref: MassAvg: "343.22"
xref: MassMono: "343.066832"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0596
is_a: MOD:00005 ! O-glycosyl-L-threonine
is_a: MOD:01804 ! glycosylphosphorylated residue

[Term]
id: MOD:01618
name: L-alanyl-L-isoaspartyl cyclopeptide
def: "A protein modification that effectively converts an L-alaine residue and an L-asparagine residue to L-alanyl-L-isoaspartyl cyclopeptide." [PubMed:19928958, PubMed:3207697, RESID:AA0515]
comment: Cross-link 2.
synonym: "(2S,5S)-2-methyl-3,7-dioxo-1,4-diazepane-5-carboxylic acid" EXACT RESID-systematic []
synonym: "1,4.2-anhydro(L-alanyl-L-aspartic acid)" EXACT RESID-alternate []
synonym: "CROSSLNK Alanine isoaspartyl cyclopeptide (Ala-Asn)" EXACT UniProt-feature []
synonym: "L-alanyl-L-isoaspartyl cyclopeptide" EXACT RESID-name []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 7 H 9 N 2 O 3"
xref: MassAvg: "169.16"
xref: MassMono: "169.061317"
xref: Origin: "A, N"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0418
is_a: MOD:00688 ! isopeptide crosslinked residues
is_a: MOD:02040 ! crosslinked L-alanine residue
is_a: MOD:02042 ! crosslinked L-asparagine residue
is_a: MOD:00946 ! crosslinked residues with loss of ammonia

[Term]
id: MOD:01619
name: multisulfide crosslinked residues
def: "A protein modification that crosslinks two cysteine residues by formation of a chain of two or more bonded sulfur atoms." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00033 ! crosslinked residues
is_a: MOD:02044 ! crosslinked L-cysteine residue

[Term]
id: MOD:01620
name: polysulfide crosslinked residues
def: "A protein modification that crosslinks two cysteine residues by formation of a chain of three or more bonded sulfur atoms." [PubMed:18688235]
is_a: MOD:00860 ! sulfur containing modified residue
is_a: MOD:01619 ! multisulfide crosslinked residues

[Term]
id: MOD:01621
name: flavin crosslinked residues
def: "A protein modification that crosslinks two or more amino acid residues by forming an adduct with a compound containing a flavin group." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00033 ! crosslinked residues
is_a: MOD:00697 ! flavin modified residue

[Term]
id: MOD:01622
name: monohydroxylated tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to one of several monohydroxylated tryptophan residues, including 3-hydroxy-L-tryptophan and 7'-hydroxy-L-tryptophan." [OMSSA:90, Unimod:35#W]
synonym: "Oxidation" RELATED PSI-MS-label []
synonym: "oxyw" EXACT OMSSA-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 11 H 10 N 2 O 2"
xref: MassAvg: "202.21"
xref: MassMono: "202.074228"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:35"
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:01623
name: 1-thioglycine (C-terminal)
def: "A protein modification that effectively converts a glycine residue to a C-terminal 1-thioglycine." [PubMed:11463785, PubMed:19145231, PubMed:9367957, RESID:AA0265#var]
subset: PSI-MOD-slim
xref: DiffAvg: "16.06"
xref: DiffFormula: "C 0 H 0 N 0 O -1 S 1"
xref: DiffMono: "15.977156"
xref: Formula: "C 2 H 3 N 1 S 1"
xref: MassAvg: "73.11"
xref: MassMono: "72.998620"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:01625 ! 1-thioglycine

[Term]
id: MOD:01624
name: (2-aminosuccinimidyl)acetic acid (Asn)
def: "A protein modification that crosslinks an asparagine and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the release of ammonia." [PubMed:10801322, PubMed:2015294, RESID:AA0441#ASN]
comment: Cross-link 2.
subset: PSI-MOD-slim
synonym: "(2-aminosuccinimidyl)acetic acid" EXACT RESID-name []
synonym: "(3-amino-2,5-dioxo-1-pyrrolidinyl)acetic acid" EXACT RESID-alternate []
synonym: "[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]acetic acid" EXACT RESID-systematic []
synonym: "anhydroaspartyl glycine" EXACT RESID-alternate []
synonym: "aspartimide glycine" EXACT RESID-alternate []
synonym: "CROSSLNK (2-aminosuccinimidyl)acetic acid (Asn-Gly)" EXACT UniProt-feature []
synonym: "N-(2-aminosuccinyl)glycine" EXACT RESID-alternate []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 6 H 6 N 2 O 3"
xref: MassAvg: "154.13"
xref: MassMono: "154.037842"
xref: Origin: "G, N"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0450
is_a: MOD:02042 ! crosslinked L-asparagine residue
is_a: MOD:00946 ! crosslinked residues with loss of ammonia
is_a: MOD:01628 ! (2-aminosuccinimidyl)acetic acid

[Term]
id: MOD:01625
name: 1-thioglycine
def: "A protein modification that effectively converts a glycine residue to 1-thioglycine." [PubMed:11463785, PubMed:9367957, RESID:AA0265]
comment: This modification occurs naturally in two forms. At an interior peptide location (MOD:00270) it exists as aminoethanethionic acid, or aminoethanethioic O-acid. At the C-terminal (MOD:01623) it exists as aminoethanethiolic acid, or aminoethanethioic S-acid [JSG].
subset: PSI-MOD-slim
synonym: "1-thioglycine" EXACT RESID-name []
synonym: "2-amino-1-sulfanylethanone" EXACT RESID-alternate []
synonym: "aminoethanethioic acid" EXACT RESID-systematic []
synonym: "aminothioacetic acid" EXACT RESID-alternate []
synonym: "Carboxy->Thiocarboxy" RELATED PSI-MS-label []
synonym: "MOD_RES 1-thioglycine" EXACT UniProt-feature []
synonym: "S(O)Gly" EXACT PSI-MOD-label []
synonym: "thiocarboxylic acid" RELATED Unimod-description []
xref: DiffAvg: "16.06"
xref: DiffFormula: "C 0 H 0 N 0 O -1 S 1"
xref: DiffMono: "15.977156"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "G"
xref: Source: "natural"
is_a: MOD:00749 ! sulfur substitution for oxygen
is_a: MOD:00908 ! modified glycine residue

[Term]
id: MOD:01626
name: L-cystine
def: "A protein modification that forms L-cystine by forming a disulfide bond that either cross-links two peptidyl L-cysteine residues, or modifies a peptidyl cysteine with a free cysteine." [ChEBI:16283, PubMed:1988019, PubMed:2001356, PubMed:2076469, PubMed:3083866, PubMed:366603, PubMed:7918467, PubMed:8344916, RESID:AA0025]
comment: This modification occurs naturally in two forms. It exists as a disulfide cross-link of two cysteine residues (MOD:00034), or as a disulfide cross-link of a cysteine residues and a free cysteine (MOD:00765).
subset: PSI-MOD-slim
synonym: "(2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid)" EXACT RESID-systematic []
synonym: "2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid" RELATED RESID-misnomer []
synonym: "3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid)" EXACT RESID-alternate []
synonym: "3,3'-dithiobis(2-aminopropanoic acid)" EXACT RESID-alternate []
synonym: "3,3'-dithiobisalanine" EXACT RESID-alternate []
synonym: "3,3'-dithiodialanine" EXACT RESID-alternate []
synonym: "beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide" EXACT RESID-alternate []
synonym: "beta,beta'-dithiodialanine" EXACT RESID-alternate []
synonym: "bis(alpha-aminopropionic acid)-beta-disulfide" EXACT RESID-alternate []
synonym: "bis(beta-amino-beta-carboxyethyl)disulfide" EXACT RESID-alternate []
synonym: "Cys2" EXACT PSI-MOD-label []
synonym: "Cystine ((Cys)2)" EXACT DeltaMass-label []
synonym: "dicysteine" EXACT RESID-alternate []
synonym: "L-cystine" EXACT RESID-name []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "none"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01627
name: L-cysteinyl-L-selenocysteine
def: "A protein modification that forms L-cysteinyl-L-selenocysteine either by the natural process of cross-linking an L-cysteine residue and an L-selenocysteine residue, or by the hypothetical process of substituting a selenium for a sulfur atom in cystine." [PubMed:12911312, PubMed:18688235]
comment: Cross-link 2.
subset: PSI-MOD-slim
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 6 H 8 N 2 O 2 S 1 Se 1"
xref: MassAvg: "251.17"
xref: MassMono: "251.947170"
xref: Origin: "C, X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:02044 ! crosslinked L-cysteine residue

[Term]
id: MOD:01628
name: (2-aminosuccinimidyl)acetic acid
def: "A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following glycine residue." [PubMed:10801322, PubMed:18688235]
comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue.
subset: PSI-MOD-slim
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 6 H 6 N 2 O 3"
xref: MassAvg: "154.13"
xref: MassMono: "154.037842"
xref: Origin: "G, X"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:01944 ! 2-aminosuccinimide ring crosslinked residues

[Term]
id: MOD:01629
name: cyclo[(prolylserin)-O-yl] cysteinate
def: "A protein modification that forms cyclo[(prolylserin)-O-yl] cysteinate by the natural process of cross-linking an L-cysteine residue an L-proline residue, and an L-serine residue, or by effectively modifying a cysteine residue." [PubMed:7961166, RESID:AA0489]
synonym: "(3,6-dioxopyrrolo[4,5-a]piperazin-2-yl)methyl cysteinate" EXACT RESID-alternate []
synonym: "[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]methyl (2R)-2-amino-3-sulfanylpropanoate" EXACT RESID-systematic []
synonym: "cyclo[(prolylserin)-O-yl] cysteinate" EXACT RESID-name []
synonym: "MOD_RES Cyclo[(prolylserin)-O-yl] cysteinate" EXACT UniProt-feature []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 11 H 16 N 3 O 4 S 1"
xref: MassAvg: "286.33"
xref: MassMono: "286.086152"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:02044 ! crosslinked L-cysteine residue

[Term]
id: MOD:01630
name: N6-(L-isoglutamyl)-L-lysine
def: "A protein modification that effectively crosslinks either an  L-glutamine residue or an L-glutamic acid residue with an L-lysine residue by an isopeptide bond to form  N6-(L-isoglutamyl)-L-lysine ." [ChEBI:21863, DeltaMass:0, PubMed:2461365, PubMed:5637041, PubMed:5656070, PubMed:8598899, RESID:AA0124]
comment: Cross-link 2.
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-([(4S)-4-amino-4-carboxybutanoyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-6-([4-azanyl-4-carboxybutanoyl]azanyl)hexanoic acid" EXACT RESID-alternate []
synonym: "5-glutamyl N6-lysine" EXACT RESID-alternate []
synonym: "N alpha -(gamma-Glutamyl)-lysine" EXACT DeltaMass-label []
synonym: "N(epsilon)-(gamma-glutamyl)lysine" EXACT RESID-alternate []
synonym: "N6-(L-isoglutamyl)-L-lysine" EXACT RESID-name []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 11 H 17 N 3 O 3"
xref: MassAvg: "239.27"
xref: MassMono: "239.126991"
xref: Origin: "K, X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0397
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01875 ! N6-acylated L-lysine
is_a: MOD:00688 ! isopeptide crosslinked residues
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:01631
name: L-alanine removal
def: "A protein modification that effectively removes or replaces an L-alanine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-alanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-71.08"
xref: DiffFormula: "C -3 H -5 N -1 O -1"
xref: DiffMono: "-71.037114"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00901 ! modified L-alanine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01632
name: L-arginine removal
def: "A protein modification that effectively removes or replaces an L-arginine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-arginine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-156.19"
xref: DiffFormula: "C -6 H -12 N -4 O -1"
xref: DiffMono: "-156.101111"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00902 ! modified L-arginine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01633
name: L-asparagine removal
def: "A protein modification that effectively removes or replaces an L-asparagine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-asparagine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-114.10"
xref: DiffFormula: "C -4 H -6 N -2 O -2"
xref: DiffMono: "-114.042927"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00903 ! modified L-asparagine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01634
name: L-aspartic acid removal
def: "A protein modification that effectively removes or replaces an L-aspartic acid." [PubMed:18688235]
comment: This represents the loss or replacement of an L-aspartic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-115.09"
xref: DiffFormula: "C -4 H -5 N -1 O -3"
xref: DiffMono: "-115.026943"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00904 ! modified L-aspartic acid residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01635
name: L-cysteine removal
def: "A protein modification that effectively removes or replaces an L-cysteine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-cysteine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-103.14"
xref: DiffFormula: "C -3 H -5 N -1 O -1 S -1"
xref: DiffMono: "-103.009185"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01636
name: L-glutamic acid removal
def: "A protein modification that effectively removes or replaces an L-glutamic acid." [PubMed:18688235]
comment: This represents the loss or replacement of an L-glutamic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-129.12"
xref: DiffFormula: "C -5 H -7 N -1 O -3"
xref: DiffMono: "-129.042593"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00906 ! modified L-glutamic acid residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01637
name: L-glutamine removal
def: "A protein modification that effectively removes or replaces an L-glutamine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-glutamine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-128.13"
xref: DiffFormula: "C -5 H -8 N -2 O -2"
xref: DiffMono: "-128.058578"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00907 ! modified L-glutamine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01638
name: glycine removal
def: "A protein modification that effectively removes or replaces a glycine." [PubMed:18688235]
comment: This represents the loss or replacement of an glycine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-57.05"
xref: DiffFormula: "C -2 H -3 N -1 O -1"
xref: DiffMono: "-57.021464"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00908 ! modified glycine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01639
name: L-histidine removal
def: "A protein modification that effectively removes or replaces an L-histidine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-histidine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-137.14"
xref: DiffFormula: "C -6 H -7 N -3 O -1"
xref: DiffMono: "-137.058912"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01640
name: L-isoleucine removal
def: "A protein modification that effectively removes or replaces an L-isoleucine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-isoleucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-113.16"
xref: DiffFormula: "C -6 H -11 N -1 O -1"
xref: DiffMono: "-113.084064"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00910 ! modified L-isoleucine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01641
name: L-leucine removal
def: "A protein modification that effectively removes or replaces an L-leucine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-leucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-113.16"
xref: DiffFormula: "C -6 H -11 N -1 O -1"
xref: DiffMono: "-113.084064"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "L"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00911 ! modified L-leucine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01642
name: L-lysine removal
def: "A protein modification that effectively removes or replaces an L-lysine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-lysine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-128.18"
xref: DiffFormula: "C -6 H -12 N -2 O -1"
xref: DiffMono: "-128.094963"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01643
name: L-methionine removal
def: "A protein modification that effectively removes or replaces an L-methionine." [OMSSA:9, PubMed:3327521, Unimod:765]
comment: This represents the loss or replacement of an L-methionine residue in a polypeptide, including initiator methionine removal in eukaryotes. It may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution [JSG].
subset: PSI-MOD-slim
synonym: "Met-loss" RELATED Unimod-interim []
synonym: "ntermmcleave" EXACT OMSSA-label []
xref: DiffAvg: "-131.19"
xref: DiffFormula: "C -5 H -9 N -1 O -1 S -1"
xref: DiffMono: "-131.040485"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:765"
is_a: MOD:00913 ! modified L-methionine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01644
name: L-phenylalanine removal
def: "A protein modification that effectively removes or replaces an L-phenylalanine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-phenylalanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-147.18"
xref: DiffFormula: "C -9 H -9 N -1 O -1"
xref: DiffMono: "-147.068414"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "F"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00914 ! modified L-phenylalanine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01645
name: L-proline removal
def: "A protein modification that effectively removes or replaces an L-proline." [PubMed:18688235]
comment: This represents the loss or replacement of an L-proline residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-97.12"
xref: DiffFormula: "C -5 H -7 N -1 O -1"
xref: DiffMono: "-97.052764"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00915 ! modified L-proline residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01646
name: L-serine removal
def: "A protein modification that effectively removes or replaces an L-serine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-serine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-87.08"
xref: DiffFormula: "C -3 H -5 N -1 O -2"
xref: DiffMono: "-87.032028"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01647
name: L-threonine removal
def: "A protein modification that effectively removes or replaces an L-threonine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-threonine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-101.10"
xref: DiffFormula: "C -4 H -7 N -1 O -2"
xref: DiffMono: "-101.047678"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01648
name: L-tryptophan removal
def: "A protein modification that effectively removes or replaces an L-tryptophan." [PubMed:18688235]
comment: This represents the loss or replacement of an L-tryptophan residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-186.21"
xref: DiffFormula: "C -11 H -10 N -2 O -1"
xref: DiffMono: "-186.079313"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00918 ! modified L-tryptophan residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01649
name: L-tyrosine removal
def: "A protein modification that effectively removes or replaces an L-tyrosine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-tyrosine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-163.18"
xref: DiffFormula: "C -9 H -9 N -1 O -2"
xref: DiffMono: "-163.063329"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01650
name: L-valine removal
def: "A protein modification that effectively removes or replaces an L-valine." [PubMed:18688235]
comment: This represents the loss or replacement of an L-valine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: DiffAvg: "-99.13"
xref: DiffFormula: "C -5 H -9 N -1 O -1"
xref: DiffMono: "-99.068414"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "V"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00920 ! modified L-valine residue
is_a: MOD:01651 ! natural, standard, encoded residue removal

[Term]
id: MOD:01651
name: natural, standard, encoded residue removal
def: "A protein modification that effectively removes a natural, standard, encoded residue." [PubMed:18688235]
comment: This represents the loss of an encoded residue in a polypeptide.
subset: PSI-MOD-slim
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00009 ! natural residue
is_a: MOD:01156 ! protein modification characterized by chemical process

[Term]
id: MOD:01652
name: sulfonyl halide reagent derivatized residue
def: "A protein modification that is produced by formation of an adduct with a sulfonyl halide compound used as a reagent." [PubMed:18688235]
comment: These reagents typically react with N6-amino group of lysine residues and a free alpha-amino group of a peptide.
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01653
name: dansyl chloride derivatized residue
def: "A protein modification that is produced by formation of an adduct with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride." [DeltaMass:0, Unimod:139]
synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED Unimod-description []
synonym: "Dansyl" RELATED PSI-MS-label []
synonym: "Dansyl (Dns)" EXACT DeltaMass-label []
synonym: "DansylRes" EXACT PSI-MOD-label []
xref: DiffAvg: "233.29"
xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1"
xref: DiffMono: "233.051050"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:139"
is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue

[Term]
id: MOD:01654
name: N6-Dansyl derivatized lysine
def: "A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form N6-Dansyl-lysine." [Unimod:139#K]
synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED Unimod-description []
synonym: "Dansyl" RELATED PSI-MS-label []
synonym: "N6DansylLys" EXACT PSI-MOD-label []
xref: DiffAvg: "233.29"
xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1"
xref: DiffMono: "233.051050"
xref: Formula: "C 18 H 23 N 3 O 3 S 1"
xref: MassAvg: "361.46"
xref: MassMono: "361.146013"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:139"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01653 ! dansyl chloride derivatized residue

[Term]
id: MOD:01655
name: alpha-amino-Dansyl derivatized residue
def: "A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form an alpha-amino-Dansyl-derivatized residue." [Unimod:139#N-term]
synonym: "5-dimethylaminonaphthalene-1-sulfonyl" RELATED Unimod-description []
synonym: "Dansyl" RELATED PSI-MS-label []
synonym: "N2DansylRes" EXACT PSI-MOD-label []
xref: DiffAvg: "233.29"
xref: DiffFormula: "C 12 H 11 N 1 O 2 S 1"
xref: DiffMono: "233.051050"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:139"
is_a: MOD:01653 ! dansyl chloride derivatized residue

[Term]
id: MOD:01656
name: Dabsyl chloride derivatized residue
def: "A protein modification that is produced by formation of an adduct with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, Dabsyl chloride." [PubMed:18688235]
synonym: "4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl" EXACT PSI-MOD-alternate []
synonym: "DabsylRes" EXACT PSI-MOD-label []
xref: DiffAvg: "287.34"
xref: DiffFormula: "C 14 H 13 N 3 O 2 S 1"
xref: DiffMono: "287.072848"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01652 ! sulfonyl halide reagent derivatized residue

[Term]
id: MOD:01657
name: N6-Dabsyl derivatized lysine
def: "A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form N6-Dabsyl-lysine." [PubMed:18688235]
synonym: "N6-[4-([4-(dimethylamino)phenyl]diazenyl)benzenesulfonyl]lysine" EXACT PSI-MOD-alternate []
synonym: "N6DabsylLys" EXACT PSI-MOD-label []
xref: DiffAvg: "287.34"
xref: DiffFormula: "C 14 H 13 N 3 O 2 S 1"
xref: DiffMono: "287.072848"
xref: Formula: "C 20 H 25 N 5 O 3 S 1"
xref: MassAvg: "415.51"
xref: MassMono: "415.167811"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01656 ! Dabsyl chloride derivatized residue

[Term]
id: MOD:01658
name: alpha-amino-Dabsyl derivatized residue
def: "A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form an alpha-amino-Dabsyl-derivatized residue." [PubMed:18688235]
synonym: "N2DabsylRes" EXACT PSI-MOD-label []
xref: DiffAvg: "287.34"
xref: DiffFormula: "C 14 H 13 N 3 O 2 S 1"
xref: DiffMono: "287.072848"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:01656 ! Dabsyl chloride derivatized residue

[Term]
id: MOD:01659
name: Uniblue A derivatized residue
def: "A protein modification that is produced by formation of an adduct with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A." [PubMed:18688235]
comment: This reagent has a reactive sulfonyl vinyl and typically reacts with the free thiol group of cysteine residues.
synonym: "1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid" EXACT PSI-MOD-alternate []
synonym: "1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonic acid" EXACT PSI-MOD-alternate []
synonym: "Uniblue A" EXACT PSI-MOD-alternate []
synonym: "UniblueARes" EXACT PSI-MOD-label []
xref: DiffAvg: "484.50"
xref: DiffFormula: "C 22 H 16 N 2 O 7 S 2"
xref: DiffMono: "484.039893"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01660
name: Uniblue A derivatized cysteine
def: "A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A cysteine adduct." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate []
synonym: "1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate []
synonym: "SUniblueACys" EXACT PSI-MOD-label []
synonym: "Uniblue A" EXACT PSI-MOD-alternate []
xref: DiffAvg: "484.50"
xref: DiffFormula: "C 22 H 16 N 2 O 7 S 2"
xref: DiffMono: "484.039893"
xref: Formula: "C 25 H 21 N 3 O 8 S 3"
xref: MassAvg: "587.64"
xref: MassMono: "587.049078"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01659 ! Uniblue A derivatized residue

[Term]
id: MOD:01661
name: pyruvic acid (Tyr)
def: "A protein modification that effectively converts an L-tyrosine residue to pyruvic acid." [PubMed:10085076, PubMed:3042771, PubMed:500639, PubMed:8464063, RESID:AA0127#TYR]
synonym: "2-oxopropanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES Pyruvic acid (Tyr)" EXACT UniProt-feature []
synonym: "pyruvic acid" EXACT RESID-name []
xref: DiffAvg: "-93.13"
xref: DiffFormula: "C -6 H -7 N -1 O 0"
xref: DiffMono: "-93.057849"
xref: Formula: "C 3 H 3 O 2"
xref: MassAvg: "71.06"
xref: MassMono: "71.013304"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0662
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01154 ! pyruvic acid

[Term]
id: MOD:01662
name: N5-(ADP-ribosyl)-L-glutamine
def: "A protein modification that effectively converts an L-glutamine residue to N5-(ADP-ribosyl)-L-glutamine." [PubMed:20185726, RESID:AA0518]
synonym: "(S)-2-amino-4-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]amino)-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "N5-(ADP-ribosyl)-L-glutamine" EXACT RESID-name []
synonym: "N5-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-glutamine" EXACT RESID-alternate []
synonym: "N5-alpha-D-ribofuranosyl-L-glutamine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate []
xref: DiffAvg: "541.30"
xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2"
xref: DiffMono: "541.061109"
xref: Formula: "C 20 H 29 N 7 O 15 P 2"
xref: MassAvg: "669.43"
xref: MassMono: "669.119687"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue
is_a: MOD:00907 ! modified L-glutamine residue

[Term]
id: MOD:01663
name: O-(ADP-ribosyl)-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-(ADP-ribosyl)-L-threonine." [PubMed:20185726, RESID:AA0519]
synonym: "(S)-2-amino-3-([adenosine 5'-(trihydrogen diphosphate) 5'->5'-ester with alpha-D-ribofuranosyl]oxy)-butanoic acid" EXACT RESID-systematic []
synonym: "O-(ADP-ribosyl)-L-threonine" EXACT RESID-name []
synonym: "O3-(ADP-ribosyl)-L-threonine" EXACT RESID-alternate []
synonym: "O3-[alpha-D-ribofuranoside 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)]-L-threonine" EXACT RESID-alternate []
synonym: "O3-alpha-D-ribofuranosyl-L-threonine 5'->5'-ester with adenosine 5'-(trihydrogen diphosphate)" EXACT RESID-alternate []
xref: DiffAvg: "541.30"
xref: DiffFormula: "C 15 H 21 N 5 O 13 P 2"
xref: DiffMono: "541.061109"
xref: Formula: "C 19 H 28 N 6 O 15 P 2"
xref: MassAvg: "642.41"
xref: MassMono: "642.108787"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00752 ! adenosine diphosphoribosyl (ADP-ribosyl) modified residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:01664
name: 7'-hydroxy-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to a 7'-hydroxy-L-tryptophan." [PubMed:20223990, RESID:AA0520]
synonym: "(2S)-2-amino-3-(7-hydroxy-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "7'-hydroxy-L-tryptophan" EXACT RESID-name []
synonym: "7-hydroxy-L-tryptophan" EXACT RESID-alternate []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 11 H 10 N 2 O 2"
xref: MassAvg: "202.21"
xref: MassMono: "202.074228"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0427
is_a: MOD:01622 ! monohydroxylated tryptophan

[Term]
id: MOD:01665
name: N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine
def: "A protein modification that effectively crosslinks an N-terminal L-valine residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine." [PubMed:20185759, RESID:AA0521]
synonym: "(2S)-2-[(3R,4R)-3,4-dihydroxy-5-(phosphonooxy)pentylidene]amino-3-methylbutanoic acid" EXACT RESID-systematic []
synonym: "ACT_SITE Schiff-base intermediate with DNA; via amino nitrogen" EXACT UniProt-feature []
synonym: "DNA glycosylase valine Schiff base intermediate" EXACT RESID-alternate []
synonym: "N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine" EXACT RESID-name []
xref: Origin: "V"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
is_a: MOD:00750 ! deoxyribonucleic acid linked residue
is_a: MOD:00920 ! modified L-valine residue

[Term]
id: MOD:01666
name: epicocconone derivatized residue
def: "A protein modification that is produced by formation of an adduct with epicocconone." [PubMed:18688235]
synonym: "(6S,9aS)-6-(hydroxymethyl)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-9a-methyl-5,6-dihydro-2H-furo[3,2-g]isochromene-2,9(9aH)-dione" EXACT PSI-MOD-alternate []
synonym: "Deep Purple" EXACT PSI-MOD-alternate []
synonym: "LavaPurple" EXACT PSI-MOD-alternate []
synonym: "Lightning Fast" EXACT PSI-MOD-alternate []
xref: DiffAvg: "410.42"
xref: DiffFormula: "C 23 H 22 O 7"
xref: DiffMono: "410.136553"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01667
name: N6-epicoccononyl lysine adduct
def: "A protein modification that is produced by formation of an adduct with epicocconone." [PubMed:18688235]
synonym: "(6Z,7aS)-3-[(1Z,4E,6E,8E)-1-hydroxy-3-oxodeca-1,4,6,8-tetraen-1-yl]-7a-methyl-6-[([(1S)-1-amino-1-carboxylpentyl]amino)methylidene]-5-[(2S)-2,3-dihydroxypropyl]-1-benzofuran-2,7(6H,7aH)-dione" EXACT PSI-MOD-alternate []
synonym: "DeepPurple" EXACT PSI-MOD-alternate []
synonym: "LavaPurple" EXACT PSI-MOD-alternate []
synonym: "Lightning Fast" EXACT PSI-MOD-alternate []
xref: DiffAvg: "410.42"
xref: DiffFormula: "C 23 H 22 O 7"
xref: DiffMono: "410.136553"
xref: Formula: "C 29 H 34 N 2 O 8"
xref: MassAvg: "538.60"
xref: MassMono: "538.231516"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01666 ! epicocconone derivatized residue

[Term]
id: MOD:01668
name: O4-(8alpha-FAD)-L-aspartate
def: "A protein modification that effectively converts an L-aspartic acid residue to O4-(8alpha-FAD)-L-aspartate." [PubMed:20080101, RESID:AA0522]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-4-oxo-4-[8alpha-riboflavin 5'-(trihydrogen diphosphate) 5'->5'-ester with adenosine]oxybutanoic acid" EXACT RESID-systematic []
synonym: "8alpha-[(4-aspartyl)oxy]FAD" EXACT RESID-alternate []
synonym: "O4-(8alpha-FAD)-L-aspartate" EXACT RESID-name []
xref: DiffAvg: "783.54"
xref: DiffFormula: "C 27 H 31 N 9 O 15 P 2"
xref: DiffMono: "783.141485"
xref: Formula: "C 31 H 36 N 10 O 18 P 2"
xref: MassAvg: "898.63"
xref: MassMono: "898.168428"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00895 ! FAD modified residue
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:01669
name: trimethyl-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to N(omega),N(omega),N'(omega)-trimethyl-L-arginine." [OMSSA:117, PubMed:11704273, PubMed:602668, RESID:AA0523, Unimod:37#R]
synonym: "(2S)-2-amino-5-([(dimethylamino)(methylamino)methylidene]amino)pentanoic acid" EXACT RESID-systematic []
synonym: "(2S)-2-amino-5-([(dimethylamino)(methylimino)methyl]amino)pentanoic acid" EXACT RESID-alternate []
synonym: "2-[(4S)-4-amino-5-oxopentyl]-1,1,3-trimethylguanidine" EXACT RESID-alternate []
synonym: "N(G)-trimethylarginine" EXACT RESID-alternate []
synonym: "N5-[(dimethylamino)(imino)methyl]ornithine" EXACT RESID-alternate []
synonym: "NoNoNo'Me3Arg" EXACT PSI-MOD-label []
synonym: "omega-N,omega-N,omega-N'-trimethyl-L-arginine" EXACT RESID-name []
synonym: "tri-Methylation" RELATED Unimod-description []
synonym: "Trimethyl" RELATED PSI-MS-label []
synonym: "trimethylationr" EXACT OMSSA-label []
xref: DiffAvg: "42.08"
xref: DiffFormula: "C 3 H 6 N 0 O 0"
xref: DiffMono: "42.046950"
xref: Formula: "C 9 H 18 N 4 O 1"
xref: MassAvg: "198.27"
xref: MassMono: "198.148061"
xref: Origin: "R"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:37"
is_a: MOD:00430 ! trimethylated residue
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:00658 ! methylated arginine

[Term]
id: MOD:01670
name: N6-chloro-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine." [PubMed:16091367, PubMed:16195462, PubMed:17260957, RESID:AA0524]
synonym: "(2S)-2-amino-6-(chloroamino)hexanoic acid" EXACT RESID-systematic []
synonym: "epsilon-chlorolysine" EXACT RESID-alternate []
synonym: "lysine chloramine" EXACT RESID-alternate []
synonym: "N(zeta)-chlorolysine" EXACT RESID-alternate []
synonym: "N6-chloro-L-lysine" EXACT RESID-name []
synonym: "N6ClLys" EXACT PSI-MOD-label []
xref: DiffAvg: "34.44"
xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0"
xref: DiffMono: "33.961028"
xref: Formula: "C 6 Cl 1 H 11 N 2 O 1"
xref: MassAvg: "162.62"
xref: MassMono: "162.055991"
xref: Origin: "K"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01672 ! halogenated lysine
is_a: MOD:01911 ! monochlorinated residue

[Term]
id: MOD:01671
name: O-(L-isoaspartyl)-L-threonine (active site intermediate)
def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using free L-asparagine and releasing ammonia." [PubMed:8706862, RESID:AA0525#THR]
comment: This is a threonine active intermediate and not an ester cross-link of peptides [JSG].
synonym: "(2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "(2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid" EXACT RESID-alternate []
synonym: "ACT_SITE O-isoaspartyl threonine intermediate" EXACT UniProt-feature []
synonym: "O(beta)-(beta-aspartyl)threonine" EXACT RESID-alternate []
synonym: "O-(L-isoaspartyl)-L-threonine" EXACT RESID-name []
synonym: "O3-(isoaspartyl)-threonine" EXACT RESID-alternate []
xref: DiffAvg: "115.09"
xref: DiffFormula: "C 4 H 5 N 1 O 3"
xref: DiffMono: "115.026943"
xref: Formula: "C 8 H 12 N 2 O 5"
xref: MassAvg: "216.19"
xref: MassMono: "216.074621"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00671 ! O-acylated residue
is_a: MOD:01978 ! O-(L-isoaspartyl)-L-threonine

[Term]
id: MOD:01672
name: halogenated lysine
def: "A protein modification that effectively substitutes a hydrogen atom of an L-lysine residue with a halogen atom." [PubMed:18688235]
xref: Origin: "K"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00694 ! halogen containing residue

[Term]
id: MOD:01673
name: N-acetylaminohexosylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an N-acetylaminohexose group through a glycosidic bond." [Unimod:43]
subset: PSI-MOD-slim
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "HexNAcRes" EXACT PSI-MOD-label []
synonym: "N-Acetylhexosamine" RELATED Unimod-description []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:43"
is_a: MOD:00436 ! N-acetylhexosaminylated residue

[Term]
id: MOD:01674
name: N4-(N-acetylamino)hexosyl-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminohexosyl)-L-asparagine." [OMSSA:182, Unimod:43#N]
subset: PSI-MOD-slim
synonym: "(S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)amino-4-oxobutanoic acid" EXACT PSI-MOD-alternate []
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "HexNAcAsn" EXACT PSI-MOD-label []
synonym: "hexNAcN" EXACT OMSSA-label []
synonym: "N-Acetylhexosamine" RELATED Unimod-description []
synonym: "N4-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-asparagine" EXACT PSI-MOD-alternate []
synonym: "N4-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-asparagine" EXACT PSI-MOD-alternate []
synonym: "N4-(N-acetylhexosaminyl)asparagine" EXACT PSI-MOD-alternate []
synonym: "N4-asparagine-beta-N-acetylhexosaminide" EXACT PSI-MOD-alternate []
synonym: "N4-glycosyl-L-asparagine" EXACT PSI-MOD-alternate []
synonym: "N4-glycosylasparagine" EXACT PSI-MOD-alternate []
synonym: "N4HexNAcAsn" EXACT PSI-MOD-label []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "C 12 H 19 N 3 O 7"
xref: MassAvg: "317.30"
xref: MassMono: "317.122300"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:43"
is_a: MOD:00160 ! N4-glycosyl-L-asparagine
is_a: MOD:01673 ! N-acetylaminohexosylated residue

[Term]
id: MOD:01675
name: O-(N-acetylamino)hexosyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminohexosyl)-L-serine." [OMSSA:184, Unimod:43#S]
subset: PSI-MOD-slim
synonym: "(S)-2-amino-3-(2-acetamido-2-deoxy-beta-D-hexopyranosyloxy)propanoic acid" EXACT PSI-MOD-alternate []
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "hexNAcS" EXACT OMSSA-label []
synonym: "N-Acetylhexosamine" RELATED Unimod-description []
synonym: "O-(2-acetylamino-2-deoxy-beta-D-hexopyranosyl)-L-serine" EXACT PSI-MOD-alternate []
synonym: "O-(N-acetylhexosaminyl)serine" EXACT PSI-MOD-alternate []
synonym: "O-glycosylserine" EXACT PSI-MOD-alternate []
synonym: "O-seryl-beta-N-acetylhexosaminide" EXACT PSI-MOD-alternate []
synonym: "O3-(2-acetamido-2-deoxy-beta-D-hexopyranosyl)-L-serine" EXACT PSI-MOD-alternate []
synonym: "OHexNAcSer" EXACT PSI-MOD-label []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "C 11 H 18 N 2 O 7"
xref: MassAvg: "290.27"
xref: MassMono: "290.111401"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:43"
is_a: MOD:00002 ! O-glycosyl-L-serine
is_a: MOD:01673 ! N-acetylaminohexosylated residue

[Term]
id: MOD:01676
name: O-(N-acetylamino)hexosyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminohexosyl)-L-threonine." [OMSSA:185, Unimod:43#T]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-(alpha-D-2-acetamido-2-deoxyhexopyranosyloxy)butanoic acid" EXACT PSI-MOD-alternate []
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "hexNAcT" EXACT OMSSA-label []
synonym: "N-Acetylhexosamine" RELATED Unimod-description []
synonym: "O-(N-acetylhexcosaminyl)-L-threonine" EXACT PSI-MOD-alternate []
synonym: "O-glycosylthreonine" EXACT PSI-MOD-alternate []
synonym: "O3-(N-acetylhexosaminyl)threonine" EXACT PSI-MOD-alternate []
synonym: "OHexNAcThr" EXACT PSI-MOD-label []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "C 12 H 20 N 2 O 7"
xref: MassAvg: "304.30"
xref: MassMono: "304.127051"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:43"
is_a: MOD:00005 ! O-glycosyl-L-threonine
is_a: MOD:01673 ! N-acetylaminohexosylated residue

[Term]
id: MOD:01677
name: O4-(N-acetylamino)hexosyl-L-hydroxyproline
def: "A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)hexosyl-L-hydroxyproline." [PubMed:18688235]
comment: secondary to RESID:AA0030
subset: PSI-MOD-slim
synonym: "(2S,4R)-4-[2-acetamido-2-deoxy-alpha-D-hexopyranosyloxy]pyrrolidine-2-carboxylic acid" EXACT PSI-MOD-alternate []
synonym: "4-(N-acetylhexosaminyloxy)proline" EXACT PSI-MOD-alternate []
synonym: "4-[(2-N-acetylamino)-alpha-D-hexopyranosyl]oxyproline" EXACT PSI-MOD-alternate []
synonym: "alpha-2-(N-acetylamino)hexopyranosyl-4-hydroxyproline" EXACT PSI-MOD-alternate []
synonym: "HexNAc" RELATED PSI-MS-label []
synonym: "O4-glycosyl-hydroxyproline" EXACT PSI-MOD-alternate []
synonym: "O4HexNAcHyPro" EXACT PSI-MOD-label []
xref: DiffAvg: "219.19"
xref: DiffFormula: "C 8 H 13 N 1 O 6"
xref: DiffMono: "219.074287"
xref: Formula: "C 13 H 20 N 2 O 7"
xref: MassAvg: "316.31"
xref: MassMono: "316.127051"
xref: Origin: "P"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00915 ! modified L-proline residue
relationship: contains MOD:01673 ! N-acetylaminohexosylated residue

[Term]
id: MOD:01678
name: N6-carbamoyl-L-lysine
def: "A protein modification that effectively coverts L-lysine to N6-carbamoyl-L-lysine." [DeltaMass:56, OMSSA:31, PubMed:10978403, PubMed:12203680, Unimod:5#K, ChEBI:144369]
comment: This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation in solution [JSG].
subset: PSI-MOD-slim
synonym: "2-amino-6-ureido-hexanoic acid" EXACT PSI-MOD-alternate []
synonym: "Carbamyl" RELATED Unimod-interim []
synonym: "Carbamylation" RELATED Unimod-description []
synonym: "carbamylk" EXACT OMSSA-label []
synonym: "homocitrulline" EXACT PSI-MOD-alternate []
synonym: "N6-(aminocarbonyl)-L-lysine" EXACT PSI-MOD-alternate []
synonym: "N6CbmLys" EXACT PSI-MOD-label []
synonym: "MOD_RES N6-carbamoyllysine" EXACT UniProt-feature []
xref: DiffAvg: "43.02"
xref: DiffFormula: "C 1 H 1 N 1 O 1"
xref: DiffMono: "43.005814"
xref: Formula: "C 7 H 13 N 3 O 2"
xref: MassAvg: "171.20"
xref: MassMono: "171.100777"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:5"
xref: uniprot.ptm:PTM-0675
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:00398 ! carbamoylated residue

[Term]
id: MOD:01679
name: alpha-aminocarbamoylated residue
def: "A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a carbamoyl group." [DeltaMass:56, OMSSA:32, PubMed:10978403, PubMed:12203680, Unimod:5#N-term]
comment: This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation. This modification effectively blocks Edman degradation, and because it can dehydrate to a cyanate group and react with another peptide N-terminal, it can effectively block two peptide molecules [JSG].
subset: PSI-MOD-slim
synonym: "Carbamyl" RELATED Unimod-interim []
synonym: "Carbamylation" RELATED Unimod-description []
synonym: "N2CbmRes" EXACT PSI-MOD-label []
synonym: "ntermcarbamyl" EXACT OMSSA-label []
xref: DiffAvg: "43.02"
xref: DiffFormula: "C 1 H 1 N 1 O 1"
xref: DiffMono: "43.005814"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:5"
is_a: MOD:00398 ! carbamoylated residue

[Term]
id: MOD:01680
name: alpha-amino monomethylated residue
def: "A protein modification that effectively replaces one residue alpha amino or imino hydrogen with one methyl group." [OMSSA:11, OMSSA:76, Unimod:34#N-term]
comment: Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].
subset: PSI-MOD-slim
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "N2Me1Res" EXACT PSI-MOD-label []
synonym: "ntermmethyl" EXACT OMSSA-label []
synonym: "ntermpepmethyl" EXACT OMSSA-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:34"
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:01460 ! alpha-amino methylated residue

[Term]
id: MOD:01681
name: monomethylated L-aspartic acid
def: "A protein modification that effectively replaces one hydrogen atom of an L-aspartic acid residue with one methyl group." [OMSSA:16, Unimod:34#D]
synonym: "Me1Asp" EXACT PSI-MOD-label []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "methyld" EXACT OMSSA-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 5 H 7 N 1 O 3"
xref: MassAvg: "129.12"
xref: MassMono: "129.042593"
xref: Origin: "D"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00887 ! methylated aspartic acid

[Term]
id: MOD:01682
name: monomethylated L-cysteine
def: "A protein modification that effectively replaces one hydrogen atom of an L-cysteine residue with one methyl group." [OMSSA:73, Unimod:34#C]
subset: PSI-MOD-slim
synonym: "Me1Cys" EXACT PSI-MOD-label []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "methylc" EXACT OMSSA-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 4 H 7 N 1 O 1 S 1"
xref: MassAvg: "117.17"
xref: MassMono: "117.024835"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00660 ! methylated cysteine

[Term]
id: MOD:01683
name: monomethylated L-lysine
def: "A protein modification that effectively replaces one hydrogen atom of an L-lysine residue with one methyl group." [OMSSA:0]
subset: PSI-MOD-slim
synonym: "Me1Lys" EXACT PSI-MOD-label []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methylation" RELATED Unimod-description []
synonym: "methylk" EXACT OMSSA-label []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 15 N 2 O 2"
xref: MassAvg: "159.21"
xref: MassMono: "159.113353"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00663 ! methylated lysine

[Term]
id: MOD:01684
name: palmitoylated-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine." [OMSSA:92, Unimod:47]
subset: PSI-MOD-slim
synonym: "Palmitoyl" RELATED PSI-MS-label []
synonym: "Palmitoylation" RELATED Unimod-description []
synonym: "palmitoylationc" EXACT OMSSA-label []
synonym: "PamCys" EXACT PSI-MOD-label []
synonym: "Hexadecanoylated L-cysteine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0"
xref: DiffMono: "238.229666"
xref: Formula: "C 19 H 35 N 1 O 2 S 1"
xref: MassAvg: "341.55"
xref: MassMono: "341.238850"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:47"
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01685
name: alpha-amino palmitoylated residue
def: "A protein modification that effectively replaces a residue alpha-amino group with a alpha-palmitoylamino group." [Unimod:47#N-term]
subset: PSI-MOD-slim
synonym: "N2PamRes" EXACT PSI-MOD-label []
synonym: "Palmitoyl" RELATED PSI-MS-label []
synonym: "Palmitoylation" RELATED Unimod-description []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0"
xref: DiffMono: "238.229666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:47"
is_a: MOD:00651 ! N-palmitoylated residue
is_a: MOD:01696 ! alpha-amino acylated residue

[Term]
id: MOD:01686
name: alpha-amino dimethylated residue
def: "A protein modification that effectively replaces two alpha amino hydrogen atoms with two methyl group." [OMSSA:38, Unimod:36#N-term]
comment: For alpha-amino acids, both N-alpha-monomethylation and complete N-alpha protonation and trimethylation have been observed, but incomplete dimethylation has not been reported as a natural process. For N-terminal proline residues, dimethylation can only be effectively accomplished with a protonated imino group, whereas this process accounts only for dimethylation and not protonation. See MOD:00889.
synonym: "di-Methylation" RELATED Unimod-description []
synonym: "Dimethyl" RELATED PSI-MS-label []
synonym: "N2Me2Res" EXACT PSI-MOD-label []
synonym: "ntermpepdimethyl" EXACT OMSSA-label []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4"
xref: DiffMono: "28.031300"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:36"
is_a: MOD:00429 ! dimethylated residue
is_a: MOD:01460 ! alpha-amino methylated residue

[Term]
id: MOD:01687
name: alpha-amino trimethylated residue
def: "A protein modification that effectively replaces an alpha-aminium group with a trimethylaminium group." [OMSSA:12, Unimod:37#N-term]
comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Res process (MOD:01698) accounts for both protonation and trimethylation.
subset: PSI-MOD-slim
synonym: "N2Me3Res" EXACT PSI-MOD-label []
synonym: "ntermtrimethyl" EXACT OMSSA-label []
synonym: "tri-Methylation" RELATED Unimod-description []
synonym: "Trimethyl" RELATED PSI-MS-label []
xref: DiffAvg: "42.08"
xref: DiffFormula: "C 3 H 6 N 0 O 0"
xref: DiffMono: "42.046402"
xref: FormalCharge: "1+"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:37"
is_a: MOD:00430 ! trimethylated residue
is_a: MOD:01460 ! alpha-amino methylated residue
relationship: derives_from MOD:01700 ! alpha-amino protonated residue

[Term]
id: MOD:01688
name: 3-hydroxy-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to one of the diastereomeric 3-hydroxy-L-asparagine residues." [OMSSA:61, Unimod:35#N]
subset: PSI-MOD-slim
synonym: "3HyAsn" EXACT PSI-MOD-label []
synonym: "hydroxylationn" EXACT OMSSA-label []
synonym: "monohydroxylated asparagine" EXACT PSI-MOD-alternate []
synonym: "Oxidation" RELATED PSI-MS-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 4 H 6 N 2 O 3"
xref: MassAvg: "130.10"
xref: MassMono: "130.037842"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:35"
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:01689
name: alpha-carboxyl methylated residue
def: "A protein modification that effectively converts a carboxyl-terminal residue to an alpha-carboxyl (1-carboxyl) methyl ester." [OMSSA:18, OMSSA:68, Unimod:34#C-term]
subset: PSI-MOD-slim
synonym: "C1OMeRes" EXACT PSI-MOD-label []
synonym: "ctermpepmeester" EXACT OMSSA-label []
synonym: "ctermpepmethyl" EXACT OMSSA-label []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "Methyl" RELATED Unimod-alternate []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0 S 0"
xref: DiffMono: "14.015650"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: Unimod: "Unimod:34"
is_a: MOD:00393 ! O-methylated residue

[Term]
id: MOD:01690
name: N-[(12R)-12-hydroxymyristoyl]-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to N-[(12R)-12-hydroxymyristoyl]-L-cysteine." [RESID:AA0516]
synonym: "2-[(12R)-12-hydroxytetradecanoyl]amino-3-sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "LIPID N-[(12R)-12-hydroxymyristoyl]cysteine" EXACT UniProt-feature []
synonym: "N-[(12R)-12-hydroxymyristoyl]-L-cysteine" EXACT RESID-name []
synonym: "N-[(12R)-12-hydroxytetradecanoyl]cysteine" EXACT RESID-alternate []
xref: DiffAvg: "226.36"
xref: DiffFormula: "C 14 H 26 N 0 O 2 S 0"
xref: DiffMono: "226.193280"
xref: Formula: "C 17 H 32 N 1 O 3 S 1"
xref: MassAvg: "330.51"
xref: MassMono: "330.210290"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0419
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01696 ! alpha-amino acylated residue

[Term]
id: MOD:01691
name: N-(12-ketomyristoyl)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to N-(12-ketomyristoyl)-L-cysteine." [PubMed:19053188, RESID:AA0517]
synonym: "2-(12-oxotetradecanoyl)amino-3-sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "LIPID N-(12-oxomyristoyl)cysteine" EXACT UniProt-feature []
synonym: "N-(12-ketomyristoyl)-L-cysteine" EXACT RESID-name []
synonym: "N-(12-oxotetradecanoyl)cysteine" EXACT RESID-alternate []
xref: DiffAvg: "224.34"
xref: DiffFormula: "C 14 H 24 N 0 O 2 S 0"
xref: DiffMono: "224.177630"
xref: Formula: "C 17 H 30 N 1 O 3 S 1"
xref: MassAvg: "328.49"
xref: MassMono: "328.194640"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0420
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01696 ! alpha-amino acylated residue

[Term]
id: MOD:01692
name: glutamyl semialdehyde (Glu)
def: "A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl semialdehyde." [PubMed:18688235, PubMed:743268]
synonym: "Deoxy" RELATED PSI-MS-label []
synonym: "gamma-glutamyl semialdehyde" EXACT PSI-MOD-alternate []
synonym: "glutamyl 5-semialdehyde" EXACT PSI-MOD-alternate []
synonym: "glutamyl aldehyde" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-16.00"
xref: DiffFormula: "C 0 H 0 N 0 O -1"
xref: DiffMono: "-15.994915"
xref: Formula: "C 5 H 7 N 1 O 2"
xref: MassAvg: "113.12"
xref: MassMono: "113.047678"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00906 ! modified L-glutamic acid residue
is_a: MOD:01161 ! deoxygenated residue
is_a: MOD:01440 ! glutamyl semialdehyde

[Term]
id: MOD:01693
name: alpha-amino pyridylacetylated residue
def: "A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a (pyrid-3-yl)acetyl group." [OMSSA:107, PubMed:9276974, Unimod:25#N-term]
comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG].
synonym: "ntermpeppyridyl" EXACT OMSSA-label []
synonym: "Pyridylacetyl" RELATED PSI-MS-label []
synonym: "pyridylacetyl" RELATED Unimod-description []
xref: DiffAvg: "119.12"
xref: DiffFormula: "C 7 H 5 N 1 O 1"
xref: DiffMono: "119.037114"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:25"
is_a: MOD:00418 ! pyridylacetylated residue
is_a: MOD:01696 ! alpha-amino acylated residue

[Term]
id: MOD:01694
name: S-(coelenterazin-3a-yl)-L-cysteine
def: "A protein modification that effectively results from forming an adduct between an L-cysteine residue and the bioluminescent compound didehydrocoelenterazine to form S-(coelenterazin-3a-yl)-L-cysteine." [ChEBI:2311, PubMed:18997450, RESID:AA0526]
synonym: "(2R)-2-amino-3-([(4-hydroxyphenyl)(8-benzyl-3-oxo-6-[4-hydroxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-2-yl)methyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "dehydrocoelenterazine cysteine adduct" EXACT RESID-alternate []
synonym: "MOD_RES S-(coelenterazin-3a-yl)cysteine" EXACT UniProt-feature []
synonym: "S-(coelenterazin-3a-yl)-L-cysteine" EXACT RESID-name []
synonym: "symplectin chromophore" EXACT RESID-alternate []
xref: DiffAvg: "421.46"
xref: DiffFormula: "C 26 H 19 N 3 O 3 S 0"
xref: DiffMono: "421.142641"
xref: Formula: "C 29 H 24 N 4 O 4 S 1"
xref: MassAvg: "524.60"
xref: MassMono: "524.151826"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0428
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01695
name: alpha-amino 3-(carboxamidomethylthio)propanoylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 3-(carboxamidomethylthio)propanoyl group." [PubMed:15121203, Unimod:293#N-term]
synonym: "3-(carbamidomethylthio)propanoyl" RELATED Unimod-description []
synonym: "CAMthiopropanoyl" RELATED PSI-MS-label []
xref: DiffAvg: "145.18"
xref: DiffFormula: "C 5 H 7 N 1 O 2 S 1"
xref: DiffMono: "145.019749"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:293"
is_a: MOD:00612 ! 3-(carboxamidomethylthio)propanoylated residue
is_a: MOD:01696 ! alpha-amino acylated residue

[Term]
id: MOD:01696
name: alpha-amino acylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00670 ! N-acylated residue

[Term]
id: MOD:01697
name: alpha-amino 4-(2-aminoethyl)benzenesulfonylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 4-(2-aminoethyl)benzenesulfonyl group." [DeltaMass:235, PubMed:8597590, Unimod:276#N-term]
comment: See the comment for MOD:00596 [JSG].
synonym: "AEBS" RELATED PSI-MS-label []
synonym: "Aminoethylbenzenesulfonylation" RELATED Unimod-description []
xref: DiffAvg: "183.23"
xref: DiffFormula: "C 8 H 9 N 1 O 2 S 1"
xref: DiffMono: "183.035400"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:276"
is_a: MOD:00596 ! 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue

[Term]
id: MOD:01698
name: alpha-amino trimethylated protonated-residue
def: "A protein modification that effectively replaces an amino group with a trimethylaminium group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "N2Me3+Res" EXACT PSI-MOD-label []
synonym: "tri-Methylation" RELATED Unimod-description []
synonym: "Trimethyl" RELATED PSI-MS-label []
xref: DiffAvg: "43.09"
xref: DiffFormula: "C 3 H 7 N 0 O 0 S 0"
xref: DiffMono: "43.054227"
xref: FormalCharge: "1+"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00711 ! trimethylated protonated-residue
is_a: MOD:01460 ! alpha-amino methylated residue

[Term]
id: MOD:01699
name: protonated residue
def: "A protein modification that effectively adds a hydrogen cation, a proton, forming a cationic residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "H+NRes" EXACT PSI-MOD-label []
xref: DiffAvg: "1.01"
xref: DiffFormula: "C 0 H 1 N 0 O 0"
xref: DiffMono: "1.007276"
xref: FormalCharge: "1+"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:01700
name: alpha-amino protonated residue
def: "A protein modification that effectively adds a proton to a residue alpha-amnino or alpha-imino group forming an alpha-aminium or alpha-iminium group, respectively." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "N2H+NRes" EXACT PSI-MOD-label []
xref: DiffAvg: "1.01"
xref: DiffFormula: "C 0 H 1 N 0 O 0"
xref: DiffMono: "1.007276"
xref: FormalCharge: "1+"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:01699 ! protonated residue

[Term]
id: MOD:01701
name: deprotonated residue
def: "A protein modification that effectively removes a hydrogen cation, a proton, forming an anionic residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "H-NRes" EXACT PSI-MOD-label []
xref: DiffAvg: "-1.01"
xref: DiffFormula: "C 0 H -1 N 0 O 0"
xref: DiffMono: "-1.007276"
xref: FormalCharge: "1-"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:01702
name: alpha-carboxyl deprotonated residue
def: "A protein modification that effectively removes a proton from a residue 1-carboxyl group (referred to as the alpha-carboxyl), forming a carboxylate anion." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "C1H-NRes" EXACT PSI-MOD-label []
xref: DiffAvg: "-1.01"
xref: DiffFormula: "C 0 H -1 N 0 O 0"
xref: DiffMono: "-1.007276"
xref: FormalCharge: "1-"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:01701 ! deprotonated residue

[Term]
id: MOD:01703
name: dehydrobutyrine
def: "A protein modification that effectively converts a source amino acid residue to dehydrobutyrine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "beta-elim-t" EXACT OMSSA-label []
synonym: "Dehydrated" RELATED PSI-MS-label []
synonym: "Dehydrated" RELATED Unimod-interim []
synonym: "Dehydration" RELATED Unimod-description []
synonym: "dehydro" EXACT OMSSA-label []
synonym: "Dehydroamino butyric acid" EXACT DeltaMass-label []
synonym: "dHAbu" EXACT PSI-MOD-label []
synonym: "phospholosst" EXACT OMSSA-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 4 H 5 N 1 O 1"
xref: MassAvg: "83.09"
xref: MassMono: "83.037114"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:01704
name: dehydrobutyrine (Met)
def: "A protein modification that effectively converts an L-methionine residue to dehydrobutyrine, by neutral loss of methyl sulfide." [PubMed:18688235]
comment: It is expected that this neutral loss will produce a mix of (E)- and (Z)-isomers [JSG].
subset: PSI-MOD-slim
synonym: "dHAbu(Met)" EXACT PSI-MOD-label []
xref: DiffAvg: "-48.10"
xref: DiffFormula: "C -1 H -4 N 0 O 0 S -1"
xref: DiffMono: "-48.003371"
xref: Formula: "C 4 H 5 N 1 O 1"
xref: MassAvg: "83.09"
xref: MassMono: "83.037114"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00913 ! modified L-methionine residue
is_a: MOD:01703 ! dehydrobutyrine

[Term]
id: MOD:01705
name: isotope tagged reagent acylated residue
def: "A protein modification that effectively replaces a residue hydrogen with an isotope tagged reagent acyl group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue

[Term]
id: MOD:01706
name: isotope tagged reagent N-acylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00670 ! N-acylated residue

[Term]
id: MOD:01707
name: isotope tagged reagent O-acylated residue
def: "A protein modification that effectively replaces a residue hydroxyl group with an isotope tagged reagent acyloxy group." [PubMed:18688235]
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00671 ! O-acylated residue

[Term]
id: MOD:01708
name: isotope tagged reagent alpha-amino acylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:01696 ! alpha-amino acylated residue
is_a: MOD:01705 ! isotope tagged reagent acylated residue
is_a: MOD:01706 ! isotope tagged reagent N-acylated residue

[Term]
id: MOD:01709
name: iTRAQ4plex reporter+balance reagent N-acylated residue
def: "A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01706 ! isotope tagged reagent N-acylated residue

[Term]
id: MOD:01710
name: iTRAQ8plex reporter+balance reagent N-acylated residue
def: "A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01706 ! isotope tagged reagent N-acylated residue

[Term]
id: MOD:01711
name: iTRAQ4plex reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups." [Unimod:214#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:214"
is_a: MOD:01708 ! isotope tagged reagent alpha-amino acylated residue
is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01712
name: iTRAQ8plex reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups." [Unimod:214#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:214"
is_a: MOD:01708 ! isotope tagged reagent alpha-amino acylated residue
is_a: MOD:01710 ! iTRAQ8plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01713
name: iTRAQ4plex reporter+balance reagent O-acylated residue
def: "A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance acyloxy groups." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01707 ! isotope tagged reagent O-acylated residue

[Term]
id: MOD:01714
name: iTRAQ8plex reporter+balance reagent O-acylated residue
def: "A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance acyloxy groups." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01707 ! isotope tagged reagent O-acylated residue

[Term]
id: MOD:01715
name: TMT6plex reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with a Proteome Sciences TMT6plex reporter+balance group." [Unimod:214]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:214"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01705 ! isotope tagged reagent acylated residue

[Term]
id: MOD:01716
name: TMT6plex reporter fragment
def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate []
synonym: "cysTMT6plex reporter fragment" EXACT PSI-MOD-alternate []
is_a: MOD:01520 ! modification reporter fragment
relationship: derives_from MOD:01715 ! TMT6plex reporter+balance reagent acylated residue
relationship: derives_from MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01717
name: TMT6plex reporter+balance reagent N-acylated residue
def: "A protein modification that effectively replaces a residue amino- or imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01706 ! isotope tagged reagent N-acylated residue

[Term]
id: MOD:01718
name: TMT6plex reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group." [Unimod:214#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:214"
is_a: MOD:01708 ! isotope tagged reagent alpha-amino acylated residue
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue

[Term]
id: MOD:01719
name: TMT6plex reporter+balance reagent O-acylated residue
def: "A protein modification that effectively replaces a residue hydroxyl with one of the Proteome Sciences TMT6plex reagent reporter+balance acyloxy groups." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01707 ! isotope tagged reagent O-acylated residue

[Term]
id: MOD:01720
name: TMT6plex-126 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [Unimod:737]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue

[Term]
id: MOD:01721
name: TMT6plex-126 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-126 reporter+balance group." [Unimod:737#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:737"
is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal
is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue

[Term]
id: MOD:01722
name: TMT6plex-126 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [Unimod:737#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3"
xref: MassAvg: "357.26"
xref: MassMono: "357.257895"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01723
name: TMT6plex-126 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [Unimod:737#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "392.23"
xref: MassMono: "392.226261"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue

[Term]
id: MOD:01724
name: TMT6plex-126 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3"
xref: MassAvg: "366.22"
xref: MassMono: "366.221844"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue

[Term]
id: MOD:01725
name: TMT6plex-126 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "316.19"
xref: MassMono: "316.194961"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue

[Term]
id: MOD:01726
name: TMT6plex-126 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-126 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "330.21"
xref: MassMono: "330.210611"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue

[Term]
id: MOD:01727
name: TMT6plex-126 reporter fragment
def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate []
synonym: "cysTMT6plex-126 reporter fragment" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 8 H 16 (14)N 1"
xref: MassAvg: "126.13"
xref: MassMono: "126.127726"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01716 ! TMT6plex reporter fragment
relationship: derives_from MOD:01720 ! TMT6plex-126 reporter+balance reagent acylated residue
relationship: derives_from MOD:01822 ! cysTMT6plex-zero reporter+balance reagent cysteine disulfide
relationship: derives_from MOD:01823 ! cysTMT6plex-126 reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01728
name: TMT6plex-127 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [Unimod:737]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue

[Term]
id: MOD:01729
name: TMT6plex-127 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-127 reporter+balance group." [Unimod:737#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal
is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue

[Term]
id: MOD:01730
name: TMT6plex-127 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [Unimod:737#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3"
xref: MassAvg: "357.26"
xref: MassMono: "357.257895"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01731
name: TMT6plex-127 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [Unimod:737#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: MassAvg: "229.16"
xref: MassMono: "229.162932"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue

[Term]
id: MOD:01732
name: TMT6plex-127 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3"
xref: MassAvg: "366.22"
xref: MassMono: "366.221844"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue

[Term]
id: MOD:01733
name: TMT6plex-127 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "316.19"
xref: MassMono: "316.194961"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue

[Term]
id: MOD:01734
name: TMT6plex-127 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-127 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "330.21"
xref: MassMono: "330.210611"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue

[Term]
id: MOD:01735
name: TMT6plex-127 reporter fragment
def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-127 reagent acylated residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate []
synonym: "cysTMT6plex-127 reporter fragment" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 7 (13)C 1 H 16 (14)N 1"
xref: MassAvg: "127.13"
xref: MassMono: "127.131081"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01716 ! TMT6plex reporter fragment
relationship: derives_from MOD:01728 ! TMT6plex-127 reporter+balance reagent acylated residue
relationship: derives_from MOD:01824 ! cysTMT6plex-127 reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01736
name: TMT6plex-128 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [Unimod:737]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue

[Term]
id: MOD:01737
name: TMT6plex-128 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-128 reporter+balance group." [Unimod:737#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:737"
is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal
is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue

[Term]
id: MOD:01738
name: TMT6plex-128 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [Unimod:737#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3"
xref: MassAvg: "357.26"
xref: MassMono: "357.257895"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01739
name: TMT6plex-128 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [Unimod:737#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "392.23"
xref: MassMono: "392.226261"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue

[Term]
id: MOD:01740
name: TMT6plex-128 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3"
xref: MassAvg: "366.22"
xref: MassMono: "366.221844"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue

[Term]
id: MOD:01741
name: TMT6plex-128 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "316.19"
xref: MassMono: "316.194961"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue

[Term]
id: MOD:01742
name: TMT6plex-128 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-128 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "330.21"
xref: MassMono: "330.210611"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue

[Term]
id: MOD:01743
name: TMT6plex-128 reporter fragment
def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-128 reagent acylated residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate []
synonym: "cysTMT6plex-128 reporter fragment" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 6 (13)C 2 H 16 (14)N 1"
xref: MassAvg: "128.13"
xref: MassMono: "128.134436"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01716 ! TMT6plex reporter fragment
relationship: derives_from MOD:01736 ! TMT6plex-128 reporter+balance reagent acylated residue
relationship: derives_from MOD:01825 ! cysTMT6plex-128 reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01744
name: TMT6plex-129 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [Unimod:737]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue

[Term]
id: MOD:01745
name: TMT6plex-129 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-129 reporter+balance group." [Unimod:737#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:737"
is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal
is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue

[Term]
id: MOD:01746
name: TMT6plex-129 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [Unimod:737#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3"
xref: MassAvg: "357.26"
xref: MassMono: "357.257895"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01747
name: TMT6plex-129 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [Unimod:737#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "392.23"
xref: MassMono: "392.226261"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue

[Term]
id: MOD:01748
name: TMT6plex-129 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3"
xref: MassAvg: "366.22"
xref: MassMono: "366.221844"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue

[Term]
id: MOD:01749
name: TMT6plex-129 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "316.19"
xref: MassMono: "316.194961"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue

[Term]
id: MOD:01750
name: TMT6plex-129 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-129 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "330.21"
xref: MassMono: "330.210611"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue

[Term]
id: MOD:01751
name: TMT6plex-129 reporter fragment
def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-129 reagent acylated residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate []
synonym: "cysTMT6plex-129 reporter fragment" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 5 (13)C 3 H 16 (14)N 1"
xref: MassAvg: "129.14"
xref: MassMono: "129.137790"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01716 ! TMT6plex reporter fragment
relationship: derives_from MOD:01744 ! TMT6plex-129 reporter+balance reagent acylated residue
relationship: derives_from MOD:01826 ! cysTMT6plex-129 reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01752
name: TMT6plex-130 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [Unimod:737]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue
relationship: derives_from MOD:01827 ! cysTMT6plex-130 reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01753
name: TMT6plex-130 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-130 reporter+balance group." [Unimod:737#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:737"
is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal
is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue

[Term]
id: MOD:01754
name: TMT6plex-130 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [Unimod:737#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3"
xref: MassAvg: "357.26"
xref: MassMono: "357.257895"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01755
name: TMT6plex-130 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [Unimod:737#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "392.23"
xref: MassMono: "392.226261"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue

[Term]
id: MOD:01756
name: TMT6plex-130 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3"
xref: MassAvg: "366.22"
xref: MassMono: "366.221844"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue

[Term]
id: MOD:01757
name: TMT6plex-130 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "316.19"
xref: MassMono: "316.194961"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue

[Term]
id: MOD:01758
name: TMT6plex-130 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-130 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "330.21"
xref: MassMono: "330.210611"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue

[Term]
id: MOD:01759
name: TMT6plex-130 reporter fragment
def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-130 reagent acylated residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate []
synonym: "cysTMT6plex-130 reporter fragment" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 4 (13)C 4 H 16 (14)N 1"
xref: MassAvg: "130.14"
xref: MassMono: "130.141145"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01716 ! TMT6plex reporter fragment
relationship: derives_from MOD:01752 ! TMT6plex-130 reporter+balance reagent acylated residue

[Term]
id: MOD:01760
name: TMT6plex-131 reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [Unimod:737]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "cysTMT6plex-131 reporter fragment" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01715 ! TMT6plex reporter+balance reagent acylated residue
relationship: derives_from MOD:01828 ! cysTMT6plex-131 reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01761
name: TMT6plex-131 reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-131 reporter+balance group." [Unimod:737#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:737"
is_a: MOD:01718 ! TMT6plex reporter+balance reagent acylated N-terminal
is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue

[Term]
id: MOD:01762
name: TMT6plex-131 reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [Unimod:737#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3"
xref: MassAvg: "357.26"
xref: MassMono: "357.257895"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01763
name: TMT6plex-131 reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [Unimod:737#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "392.23"
xref: MassMono: "392.226261"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:737"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue

[Term]
id: MOD:01764
name: TMT6plex-131 reporter+balance reagent N'-acylated histidine
def: "A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3"
xref: MassAvg: "366.22"
xref: MassMono: "366.221844"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01717 ! TMT6plex reporter+balance reagent N-acylated residue
is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue

[Term]
id: MOD:01765
name: TMT6plex-131 reporter+balance reagent O3-acylated serine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "316.19"
xref: MassMono: "316.194961"
xref: Origin: "S"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02003 ! O3-acylated L-serine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue

[Term]
id: MOD:01766
name: TMT6plex-131 reporter+balance reagent O3-acylated threonine
def: "A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-131 reporter+balance group." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "3-[(2,6-dimethylpiperidin-1-yl)acetyl]amino)propanoyl" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "229.16"
xref: DiffFormula: "(12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2"
xref: DiffMono: "229.162932"
xref: Formula: "(12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4"
xref: MassAvg: "330.21"
xref: MassMono: "330.210611"
xref: Origin: "T"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01719 ! TMT6plex reporter+balance reagent O-acylated residue
is_a: MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue

[Term]
id: MOD:01767
name: TMT6plex-131 reporter fragment
def: "The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-131 reagent acylated residue." [PubMed:18688235]
synonym: "2,6-dimethyl-1-methylidenepiperidinium" EXACT PSI-MOD-alternate []
synonym: "Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "TMT6plex" RELATED Unimod-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 4 (13)C 4 H 16 (15)N 1"
xref: MassAvg: "131.14"
xref: MassMono: "131.138180"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01716 ! TMT6plex reporter fragment
relationship: derives_from MOD:01760 ! TMT6plex-131 reporter+balance reagent acylated residue

[Term]
id: MOD:01768
name: O-palmitoleylated residue
def: "A protein modification that effectively replaces a residue hydroxyl group with a palmitoleyloxy group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: DiffAvg: "236.40"
xref: DiffFormula: "C 16 H 28 N 0 O 1"
xref: DiffMono: "236.214016"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00671 ! O-acylated residue
is_a: MOD:01423 ! palmitoleylated residue

[Term]
id: MOD:01769
name: O-palmitoleyl-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-palmitoleyl-L-threonine." [OMSSA:188, PubMed:6642431, PubMed:8413602, RESID:AA0079#var, Unimod:431#T]
subset: PSI-MOD-slim
synonym: "(2S,3R)-2-amino-3-((Z)-9-hexadecenoyloxy)butanoic acid" EXACT PSI-MOD-alternate []
synonym: "L-threonine cis-9-hexadecenoate ester" EXACT PSI-MOD-alternate []
synonym: "mod188" EXACT OMSSA-label []
synonym: "O-palmitoleylated L-threonine" EXACT PSI-MOD-alternate []
synonym: "O3-palmitoleyl-threonine" EXACT PSI-MOD-alternate []
synonym: "Palmitoleyl" RELATED PSI-MS-label []
synonym: "palmitoleyl" RELATED Unimod-description []
xref: DiffAvg: "236.40"
xref: DiffFormula: "C 16 H 28 N 0 O 1"
xref: DiffMono: "236.214016"
xref: Formula: "C 20 H 35 N 1 O 3"
xref: MassAvg: "337.50"
xref: MassMono: "337.261694"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:431"
is_a: MOD:02004 ! O3-acylated L-threonine
is_a: MOD:01768 ! O-palmitoleylated residue

[Term]
id: MOD:01770
name: O-palmitoyl-L-threonine amide
def: "A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine amide." [PubMed:8413602, RESID:AA0079#var, RESID:AA0097#var]
synonym: "(2S,3R)-2-amino-3-(hexadecanoyloxy)butanamide" EXACT PSI-MOD-alternate []
synonym: "OPamThrN" EXACT PSI-MOD-label []
xref: DiffAvg: "254.44"
xref: DiffFormula: "C 16 H 32 N 1 O 1"
xref: DiffMono: "254.248390"
xref: Formula: "C 20 H 39 N 2 O 3"
xref: MassAvg: "355.54"
xref: MassMono: "355.296068"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:02004 ! O3-acylated L-threonine
relationship: has_functional_parent MOD:00088 ! O-palmitoyl-L-threonine
relationship: has_functional_parent MOD:00106 ! L-threonine amide

[Term]
id: MOD:01771
name: farnesyl reporter fragment
def: "The farnesyl cation protein modification reporter fragment produced by fragmentation of some farnesyl modified residues." [PubMed:15609361, PubMed:18688235]
subset: PSI-MOD-slim
synonym: "(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ylium" EXACT PSI-MOD-alternate []
synonym: "Farn+" EXACT PSI-MOD-label []
synonym: "farnesyl cation" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "C 15 H 25"
xref: MassAvg: "205.36"
xref: MassMono: "205.195077"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01520 ! modification reporter fragment
relationship: derives_from MOD:00437 ! farnesylated residue

[Term]
id: MOD:01772
name: palmityl reporter fragment
def: "The palmityl cation protein modification reporter fragment produced by fragmentation of some palmitoyl modified residues." [PubMed:18688235, PubMed:8413602]
subset: PSI-MOD-slim
synonym: "palmityl cation" RELATED PSI-MS-label []
synonym: "Pam+" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "C 16 H 31 O 1"
xref: MassAvg: "239.42"
xref: MassMono: "239.236942"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01520 ! modification reporter fragment
relationship: derives_from MOD:00440 ! palmitoylated residue

[Term]
id: MOD:01773
name: N6,N6,N6-trimethyl-L-lysine with neutral loss of trimethylamine
def: "Covalent modification of a trimethyllysine residue with secondary loss of a neutral trimethylamine molecular fragment." [PubMed:17205979, PubMed:18688235]
subset: PSI-MOD-slim
synonym: "dMe3N6Me3+Lys" EXACT PSI-MOD-label []
xref: DiffAvg: "-59.11"
xref: DiffFormula: "C -3 H -9 N -1 O 0"
xref: DiffMono: "-59.074048"
xref: FormalCharge: "1+"
xref: Formula: "C 6 H 10 N 1 O 1"
xref: MassAvg: "112.15"
xref: MassMono: "112.075690"
xref: Origin: "MOD:00083"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00431 ! modified residue with a secondary neutral loss
is_a: MOD:00912 ! modified L-lysine residue
relationship: derives_from MOD:00083 ! N6,N6,N6-trimethyl-L-lysine

[Term]
id: MOD:01774
name: N6-octanoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-octanoyl-L-lysine." [PubMed:12591875, PubMed:2215217, RESID:AA0527]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-(octanoylamino)hexanoic acid" EXACT RESID-systematic []
synonym: "epsilon-octanoyllysine" EXACT RESID-alternate []
synonym: "N(zeta)-octanoyllysine" EXACT RESID-alternate []
synonym: "N6-(1-oxooctyl)-L-lysine" EXACT RESID-alternate []
synonym: "N6-octanoyl-L-lysine" EXACT RESID-name []
xref: DiffAvg: "126.20"
xref: DiffFormula: "C 8 H 14 N 0 O 1"
xref: DiffMono: "126.104465"
xref: Formula: "C 14 H 26 N 2 O 2"
xref: MassAvg: "254.37"
xref: MassMono: "254.199428"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00666 ! octanoylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01775
name: 5-glutamyl serotonin
def: "A protein modification that effectively converts an L-glutamine residue to 5-glutamyl serotonin." [PubMed:11805836, PubMed:14697203, RESID:AA0528]
synonym: "(2S)-2-amino-5-([2-(5-hydroxy-1H-indol-3-yl)ethyl]amino)-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "5-glutamyl serotonin" EXACT RESID-name []
synonym: "N2-(gamma-glutamyl)-5-hydoxytryptamine" EXACT RESID-alternate []
synonym: "N5-[2-(5-hydroxy-3-indolyl)ethyl]glutamine" EXACT RESID-alternate []
xref: DiffAvg: "159.19"
xref: DiffFormula: "C 10 H 9 N 1 O 1"
xref: DiffMono: "159.068414"
xref: Formula: "C 15 H 17 N 3 O 3"
xref: MassAvg: "287.32"
xref: MassMono: "287.126991"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00907 ! modified L-glutamine residue

[Term]
id: MOD:01776
name: S-methylthiocarbonylaminoethylcysteine (Cys)
def: "A protein modification that effectively converts an L-cysteine residue to S-methylthiocarbonylaminoethylcysteine." [PubMed:18688235, PubMed:20608637]
comment: This modified residue is a chemical analog of N6-acetyl-L-lysine produced from L-cysteine by methylthiocarbonylaziridine (MTCA, S-methyl aziridine-1-carbothioate).
synonym: "(2R)-2-amino-3-([2-([(methylsulfanyl)carbonyl]amino)ethyl]sulfanyl)propanoic acid" EXACT PSI-MOD-alternate []
synonym: "L-cysteine N-(methylthiocarbonyl)aziridine adduct" EXACT PSI-MOD-alternate []
synonym: "MTCTK" EXACT PSI-MOD-alternate []
synonym: "N6-methylthiocarbonyl-4-thialysine" EXACT PSI-MOD-alternate []
synonym: "S-[2-([(methylthio)carbonyl]amino)ethyl]-L-cysteine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "117.17"
xref: DiffFormula: "C 4 H 7 N 1 O 1 S 1"
xref: DiffMono: "117.024835"
xref: Formula: "C 7 H 12 N 2 O 2 S 2"
xref: MassAvg: "220.31"
xref: MassMono: "220.034020"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01777
name: S-(glycyl)-L-cysteine (Gly)
def: "A protein modification that effectively converts a C-terminal glycine residue to S-(glycyl)-L-cysteine by forming a thioester bond with a free L-cysteine." [ChEBI:22050, PubMed:17726030, PubMed:18359941, PubMed:18771296, PubMed:18799456, PubMed:18842002, PubMed:3306404, RESID:AA0206]
comment: This is not the cross-linking of two peptides, but the modification of a C-terminal glycine by formation of an thioester bond with a free cysteine. For the cross-linking of two peptide see MOD:00211 [JSG].
synonym: "(2R)-2-amino-3-[(aminoacetyl)sulfanyl]propanoic acid" EXACT RESID-systematic []
synonym: "1-(cystein-S-yl)-glycinate" EXACT RESID-alternate []
synonym: "glycine cysteine thioester" EXACT RESID-alternate []
synonym: "MOD_RES CysO-cysteine adduct" EXACT UniProt-feature []
synonym: "S-(2-amino-1-oxoethyl)cysteine" EXACT RESID-alternate []
synonym: "S-(glycyl)-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "103.14"
xref: DiffFormula: "C 3 H 5 N 1 O 1 S 1"
xref: DiffMono: "103.009185"
xref: Formula: "C 5 H 9 N 2 O 3 S 1"
xref: MassAvg: "177.20"
xref: MassMono: "177.033388"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00908 ! modified glycine residue

[Term]
id: MOD:01778
name: N-(glycyl)-L-cysteine
def: "A protein modification that effectively converts a C-terminal glycine residue to N-(glycyl)-L-cysteine by forming a peptide bond with a free L-cysteine." [PubMed:18771296, PubMed:18799456, PubMed:18842002, RESID:AA0529]
synonym: "(2R)-2-[(aminoacetyl)amino]-3-sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES CysO-cysteine adduct" EXACT UniProt-feature []
synonym: "N-(2-amino-1-oxoethyl)cysteine" EXACT RESID-alternate []
synonym: "N-(glycyl)-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "103.14"
xref: DiffFormula: "C 3 H 5 N 1 O 1 S 1"
xref: DiffMono: "103.009185"
xref: Formula: "C 5 H 9 N 2 O 3 S 1"
xref: MassAvg: "177.20"
xref: MassMono: "177.033388"
xref: Origin: "G"
xref: Source: "hypothetical"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0433
is_a: MOD:00908 ! modified glycine residue

[Term]
id: MOD:01779
name: N6-(L-lysyl)-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-(L-lysyl)-L-lysine by formation of an isopeptide bond between the carboxyl group of a free lysine and the N6-amino group of the peptidyl L-lysine." [PubMed:18201202, PubMed:20729861, RESID:AA0530]
comment: This is not the cross-linking of two peptides, but the modification of a peptidyl lysine by formation of an isopeptide bond with a free lysine [JSG].
synonym: "(2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "N6-(alpha-lysyl)-lysine" EXACT RESID-alternate []
synonym: "N6-(L-lysyl)-L-lysine" EXACT RESID-name []
xref: DiffAvg: "128.18"
xref: DiffFormula: "C 6 H 12 N 2 O 1"
xref: DiffMono: "128.094963"
xref: Formula: "C 12 H 24 N 4 O 2"
xref: MassAvg: "256.35"
xref: MassMono: "256.189926"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01780
name: N6-(beta-lysyl)-L-5-hydroxylysine
def: "A protein modification that effectively converts an L-lysine residue to N6-(beta-lysyl)-L-5-hydroxylysine by formation of an isopeptide bond between the carboxyl group of a free beta-lysine and the N6-amino group of a peptidyl L-lysine." [PubMed:18201202, PubMed:20729861, RESID:AA0531]
synonym: "(2S)-2-amino-6-([(3R)-3,6-diaminohexanoyl]amino)-5-hydroxyhexanoic acid" EXACT RESID-systematic []
synonym: "5-hydroxy-N6-(beta-lysyl)-L-lysine" EXACT RESID-name []
synonym: "5-hydroxy-N6-[(3R)-beta-lysyl]lysine" EXACT RESID-alternate []
synonym: "EF-P lysine derivative" EXACT RESID-alternate []
synonym: "lysyl spermidine derivative [misidentification]" EXACT RESID-alternate []
synonym: "MOD_RES N6-(3,6-diaminohexanoyl)-5-hydroxylysine" EXACT UniProt-feature []
synonym: "N6-[(3R)-3,6-diaminohexanoyl]-L-5-hydroxylysine" EXACT RESID-alternate []
xref: DiffAvg: "144.17"
xref: DiffFormula: "C 6 H 12 N 2 O 2"
xref: DiffMono: "144.089878"
xref: Formula: "C 12 H 24 N 4 O 3"
xref: MassAvg: "272.35"
xref: MassMono: "272.184841"
xref: Origin: "K"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0474
relationship: derives_from MOD:00037 ! 5-hydroxy-L-lysine
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01781
name: N6-butanoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-butanoyl-L-lysine." [PubMed:17267393, PubMed:20715035, RESID:AA0532, Unimod:1289]
comment: The binding of histone peptides with butanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG].
synonym: "(2S)-2-amino-6-(butanoylamino)hexanoic acid" EXACT RESID-systematic []
synonym: "(2S)-2-azanyl-6-(butanoylamino)hexanoic acid" EXACT RESID-alternate []
synonym: "2-amino-6-butyrylaminocaproic acid" EXACT RESID-alternate []
synonym: "epsilon-butanoyl-L-lysine" EXACT RESID-alternate []
synonym: "epsilon-butyryl-L-lysine" EXACT RESID-alternate []
synonym: "N(zeta)-butanoyllysine" EXACT RESID-alternate []
synonym: "N6-(1-oxobutyl)-L-lysine" EXACT RESID-alternate []
synonym: "N6-butanoyl-L-lysine" EXACT RESID-name []
synonym: "N6-butyryllysine" EXACT RESID-alternate []
synonym: "MOD_RES N6-butyryllysine" EXACT UniProt-feature []
xref: DiffAvg: "70.09"
xref: DiffFormula: "C 4 H 6 N 0 O 1"
xref: DiffMono: "70.041865"
xref: Formula: "C 10 H 18 N 2 O 2"
xref: MassAvg: "198.27"
xref: MassMono: "198.136828"
xref: Origin: "K"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1289"
xref: uniprot.ptm:PTM-0637
is_a: MOD:01875 ! N6-acylated L-lysine
is_a: MOD:01997 ! N-butanoylated residue

[Term]
id: MOD:01782
name: N-methyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to N-methyl-L-serine." [PubMed:20668449, RESID:AA0533]
subset: PSI-MOD-slim
synonym: "(2S)-3-hydroxy-2-(methylamino)propanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES N-methylserine" EXACT UniProt-feature []
synonym: "N-methyl-L-serine" EXACT RESID-name []
synonym: "N-methylserine" EXACT RESID-alternate []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 4 H 7 N 1 O 2"
xref: MassAvg: "101.10"
xref: MassMono: "101.047678"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0432
is_a: MOD:01680 ! alpha-amino monomethylated residue
is_a: MOD:01800 ! N-methylated serine

[Term]
id: MOD:01783
name: N,N-dimethyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to N,N-dimethyl-L-serine." [PubMed:20668449, RESID:AA0534]
synonym: "(2S)-2-(dimethylamino)propanoic acid" EXACT RESID-systematic []
synonym: "MOD_RES N,N-dimethylserine" EXACT UniProt-feature []
synonym: "N,N-dimethyl-L-serine" EXACT RESID-name []
synonym: "N,N-dimethylserine" EXACT RESID-alternate []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4 N 0 O 0"
xref: DiffMono: "28.031300"
xref: Formula: "C 5 H 10 N 1 O 2"
xref: MassAvg: "116.14"
xref: MassMono: "116.071154"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0431
is_a: MOD:01686 ! alpha-amino dimethylated residue
is_a: MOD:01800 ! N-methylated serine

[Term]
id: MOD:01784
name: N,N,N-trimethyl-L-serine
def: "A protein modification that effectively converts an L-serine residue to N,N,N-trimethyl-L-serine." [PubMed:20668449, PubMed:3979397, RESID:AA0535]
subset: PSI-MOD-slim
synonym: "(1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanaminium" EXACT RESID-systematic []
synonym: "(1S)-1-carboxy-2-hydroxy-N,N,N-trimethylethanazanium" EXACT RESID-alternate []
synonym: "(2S)-2-trimethylammonio-3-hydroxypropanoic acid" EXACT RESID-alternate []
synonym: "MOD_RES N,N,N-trimethylserine" EXACT UniProt-feature []
synonym: "N,N,N-trimethyl-L-serine" EXACT RESID-name []
synonym: "N,N,N-trimethylserine cation" EXACT RESID-alternate []
synonym: "N,N,N-trimethylserinium" EXACT RESID-alternate []
xref: DiffAvg: "43.09"
xref: DiffFormula: "C 3 H 7 N 0 O 0"
xref: DiffMono: "43.054227"
xref: FormalCharge: "1+"
xref: Formula: "C 6 H 13 N 1 O 2"
xref: MassAvg: "131.17"
xref: MassMono: "131.094080"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0430
is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue
is_a: MOD:01800 ! N-methylated serine

[Term]
id: MOD:01785
name: O-(L-isoglutamyl)-L-threonine (active site intermediate)
def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia." [PubMed:8706862, RESID:AA0536#THR]
comment: This is not an ester cross-link of peptides [JSG].
synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate []
synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate []
synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate []
synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name []
synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate []
xref: DiffAvg: "129.12"
xref: DiffFormula: "C 5 H 7 N 1 O 3"
xref: DiffMono: "129.042593"
xref: Formula: "C 9 H 14 N 2 O 5"
xref: MassAvg: "230.22"
xref: MassMono: "230.090272"
xref: Origin: "T"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00671 ! O-acylated residue
is_a: MOD:01979 ! O-(L-isoglutamyl)-L-threonine

[Term]
id: MOD:01786
name: 3'-nitro-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to 3'-nitro-L-tyrosine." [ChEBI:44454, PubMed:16944230, PubMed:5339594, RESID:AA0537]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid" EXACT RESID-systematic []
synonym: "3'-nitro-L-tyrosine" EXACT RESID-name []
synonym: "3-nitro-L-tyrosine" EXACT RESID-alternate []
synonym: "3-nitrotyrosine" EXACT RESID-alternate []
synonym: "m-nitrotyrosine" EXACT RESID-alternate []
synonym: "meta-nitrotyrosine" EXACT RESID-alternate []
synonym: "MOD_RES 3'-Nitrotyrosine" EXACT UniProt-feature []
xref: DiffAvg: "45.00"
xref: DiffFormula: "C 0 H -1 N 1 O 2"
xref: DiffMono: "44.985078"
xref: Formula: "C 9 H 8 N 2 O 4"
xref: MassAvg: "208.17"
xref: MassMono: "208.048407"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0434
is_a: MOD:01352 ! nitrated L-tyrosine

[Term]
id: MOD:01787
name: 5'-(L-tyros-5'-yl)amino-L-tyrosine
def: "A protein modification that effectively cross-links two L-tyrosine residues through their 5' positions by amine nitrogen to form 5'-(L-tyros-5'-yl)amino-L-tyrosine." [PubMed:18781570, RESID:AA0459]
comment: Cross-link 2.
synonym: "(2S,2'S)-3,3'-[iminobis(4-hydroxybenzene-3,1-diyl)]bis(2-aminopropanoic acid)" EXACT RESID-systematic []
synonym: "5'-(L-tyros-5'-yl)amino-L-tyrosine" EXACT RESID-name []
synonym: "5'-[(tyros-5'-yl)amino]tyrosine" EXACT RESID-alternate []
synonym: "5'-tyrosyl-5'-aminotyrosine" EXACT RESID-alternate []
synonym: "bis(LTQ) linkage" EXACT RESID-alternate []
synonym: "CROSSLNK 5'-tyrosyl-5'-aminotyrosine (Tyr-Tyr) (interchain)" EXACT UniProt-feature []
xref: DiffAvg: "13.00"
xref: DiffFormula: "C 0 H -1 N 1 O 0"
xref: DiffMono: "12.995249"
xref: Formula: "C 18 H 17 N 3 O 4"
xref: MassAvg: "339.35"
xref: MassMono: "339.121906"
xref: Origin: "Y, Y"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0320
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02058 ! crosslinked L-tyrosine residue

[Term]
id: MOD:01788
name: histidine immonium ion
def: "A protein modification that effectively converts an N-terminal L-histidine residue to histidine immonium ion." [PubMed:17074506, PubMed:18688235]
comment: This fragment corresponds to the first ion in an a+ series.
subset: PSI-MOD-slim
synonym: "2-(1H-imidazolyl)ethaniminium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-27.00"
xref: DiffFormula: "C -1 H 1 N 0 O -1"
xref: DiffMono: "-26.987638"
xref: FormalCharge: "1+"
xref: Formula: "C 5 H 8 N 3 O 0"
xref: MassAvg: "110.14"
xref: MassMono: "110.071274"
xref: Origin: "H"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01527 ! residue reporter fragment

[Term]
id: MOD:01789
name: phenylalanine immonium ion
def: "A protein modification that effectively converts an N-terminal L-phenylalanine residue to phenylalanine immonium ion." [PubMed:17074506, PubMed:18688235]
comment: This fragment corresponds to the first ion in an a+ series.
subset: PSI-MOD-slim
synonym: "2-phenylethaniminium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-27.00"
xref: DiffFormula: "C -1 H 1 N 0 O -1"
xref: DiffMono: "-26.987638"
xref: FormalCharge: "1+"
xref: Formula: "C 8 H 10 N 1 O 0"
xref: MassAvg: "120.17"
xref: MassMono: "120.080776"
xref: Origin: "F"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00914 ! modified L-phenylalanine residue
is_a: MOD:01527 ! residue reporter fragment

[Term]
id: MOD:01790
name: tyrosine immonium ion
def: "A protein modification that effectively converts an an N-terminal L-tyrosine residue to tyrosine immonium ion." [PubMed:17074506, PubMed:18688235]
comment: This fragment corresponds to the first ion in an a+ series.
subset: PSI-MOD-slim
synonym: "2-(4-hydroxyphenyl)ethaniminium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-27.00"
xref: DiffFormula: "C -1 H 1 N 0 O -1"
xref: DiffMono: "-26.987638"
xref: FormalCharge: "1+"
xref: Formula: "C 8 H 10 N 1 O 1"
xref: MassAvg: "136.17"
xref: MassMono: "136.075690"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01527 ! residue reporter fragment

[Term]
id: MOD:01791
name: phosphohistidine immonium ion
def: "A protein modification that effectively converts an N-terminal phosphohistidine residue to phosphohistidine immonium ion." [PubMed:17690871, PubMed:18688235, PubMed:20847263]
comment: This fragment corresponds to the first ion in an a+ series.
subset: PSI-MOD-slim
synonym: "2-(1H-imidazolyl)ethaniminium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-27.00"
xref: DiffFormula: "C -1 H 1 N 0 O -1"
xref: DiffMono: "-26.987638"
xref: FormalCharge: "1+"
xref: Formula: "C 5 H 9 N 3 O 3 P 1"
xref: MassAvg: "190.12"
xref: MassMono: "190.037604"
xref: Origin: "MOD:00890"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:01527 ! residue reporter fragment
relationship: derives_from MOD:00890 ! phosphorylated L-histidine

[Term]
id: MOD:01792
name: phosphotyrosine immonium ion
def: "A protein modification that effectively converts an N-terminal O4'-phospho-L-tyrosine residue to tyrosine immonium ion." [PubMed:17690871, PubMed:18688235]
comment: This fragment corresponds to the first ion in an a+ series.
subset: PSI-MOD-slim
synonym: "2-(4-phosphonoxyphenyl)ethaniminium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-27.00"
xref: DiffFormula: "C -1 H 1 N 0 O -1"
xref: DiffMono: "-26.987638"
xref: FormalCharge: "1+"
xref: Formula: "C 8 H 11 N 1 O 4 P 1"
xref: MassAvg: "216.15"
xref: MassMono: "216.042021"
xref: Origin: "MOD:00048"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01527 ! residue reporter fragment
relationship: derives_from MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: MOD:01793
name: S-carboxamidomethyl-L-cysteine sulfoxide
def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfoxide." [PubMed:11212008, PubMed:17689096, PubMed:18306178, PubMed:18688235]
synonym: "CamCO" EXACT PSI-MOD-alternate []
synonym: "S-carbamoylmethyl-L-cysteine sulfoxide" EXACT PSI-MOD-alternate []
xref: DiffAvg: "73.05"
xref: DiffFormula: "C 2 H 3 N 1 O 2"
xref: DiffMono: "73.016378"
xref: Formula: "C 5 H 8 N 2 O 3 S 1"
xref: MassAvg: "176.19"
xref: MassMono: "176.025563"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00708 ! sulfur oxygenated L-cysteine
is_a: MOD:01854 ! sulfur monooxygenated residue
relationship: derives_from MOD:01060 ! S-carboxamidomethyl-L-cysteine

[Term]
id: MOD:01794
name: 1x(13)C,3x(2)H labeled monomethylated residue
def: "A protein modification that effectively replaces the methyl group of a residue containing common isotopes with a 1x(13)C,3x(2)H labeled monomethylated residue." [PubMed:18688235]
synonym: "Methyl:2H(3)13C(1)" RELATED PSI-MS-label []
xref: DiffAvg: "18.04"
xref: DiffFormula: "(13)C 1 (1)H -1 (2)H 3"
xref: DiffMono: "18.037835"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00839 ! (2)H deuterium labeled residue
is_a: MOD:00842 ! (13)C labeled residue

[Term]
id: MOD:01795
name: 1x(13)C,3x(2)H C(6)-labeled L-methionine
def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine." [PubMed:15782174, PubMed:18688235]
synonym: "Methyl:2H(3)13C(1)" RELATED PSI-MS-label []
xref: DiffAvg: "4.02"
xref: DiffFormula: "(12)C -1 (13)C 1 (1)H -3 (2)H 3"
xref: DiffMono: "4.022185"
xref: Formula: "(12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 1 S 1"
xref: MassAvg: "135.06"
xref: MassMono: "135.062670"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00839 ! (2)H deuterium labeled residue
is_a: MOD:00842 ! (13)C labeled residue
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:01796
name: 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide
def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 1x(13)C,3x(2)H C(6)-labeled L-methionine sulfoxide." [PubMed:15782174, PubMed:18688235]
xref: DiffAvg: "20.02"
xref: DiffFormula: "(12)C -1 (13)C 1 (1)H -3 (2)H 3 O 1"
xref: DiffMono: "20.017100"
xref: Formula: "(12)C 4 (13)C 1 (1)H 6 (2)H 3 N 1 O 2 S 1"
xref: MassAvg: "151.06"
xref: MassMono: "151.057585"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00839 ! (2)H deuterium labeled residue
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:01797
name: 1'-phosphohistidine immonium ion
def: "A protein modification that effectively converts an N-terminal 1'-phosphohistidine residue to 1'-phosphohistidine immonium ion." [PubMed:17690871, PubMed:18688235, PubMed:20847263]
comment: This fragment corresponds to the first ion in an a+ series.
synonym: "2-((1-phosphono-1H-imidazol-4-yl)ethaniminium" EXACT PSI-MOD-alternate []
synonym: "Ntau-phosphorylated L-histidine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-27.00"
xref: DiffFormula: "C -1 H 1 N 0 O -1"
xref: DiffMono: "-26.987638"
xref: FormalCharge: "1+"
xref: Formula: "C 5 H 9 N 3 O 3 P 1"
xref: MassAvg: "190.12"
xref: MassMono: "190.037604"
xref: Origin: "MOD:00044"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01791 ! phosphohistidine immonium ion
relationship: derives_from MOD:00044 ! 1'-phospho-L-histidine

[Term]
id: MOD:01798
name: 3'-phosphohistidine immonium ion
def: "A protein modification that effectively converts an N-terminal 3'-phosphohistidine residue to 3'-phosphohistidine immonium ion." [PubMed:18688235]
comment: This fragment corresponds to the first ion in an a+ series.
synonym: "2-(1-phosphono-1H-imidazol-5-yl)ethaniminium" EXACT PSI-MOD-alternate []
synonym: "Npi-phosphorylated L-histidine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-27.00"
xref: DiffFormula: "C -1 H 1 N 0 O -1"
xref: DiffMono: "-26.987638"
xref: FormalCharge: "1+"
xref: Formula: "C 5 H 9 N 3 O 3 P 1"
xref: MassAvg: "190.12"
xref: MassMono: "190.037604"
xref: Origin: "MOD:00045"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01791 ! phosphohistidine immonium ion
relationship: derives_from MOD:00045 ! 3'-phospho-L-histidine

[Term]
id: MOD:01799
name: methylated serine
def: "A protein modification that effectively converts an L-alanine residue to a methylated serine, such as N-methylserine, N,N-dimethylserine, or N,N,N-trimethylserine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeSer" EXACT PSI-MOD-label []
xref: Origin: "S"
is_a: MOD:00427 ! methylated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01800
name: N-methylated serine
def: "A protein modification that effectively replaces an L-serine alpha amino hydrogen with a methyl group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:01460 ! alpha-amino methylated residue
is_a: MOD:01799 ! methylated serine

[Term]
id: MOD:01801
name: protonated L-serine (L-serinium) residue
def: "A protein modification that effectively converts an L-serine residue to an L-serinium (protonated L-serine)." [PubMed:18688235]
subset: PSI-MOD-slim
xref: DiffAvg: "1.01"
xref: DiffFormula: "C 0 H 1 N 0 O 0"
xref: DiffMono: "1.007276"
xref: FormalCharge: "1+"
xref: Formula: "C 3 H 7 N 1 O 2"
xref: MassAvg: "89.09"
xref: MassMono: "89.047130"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01700 ! alpha-amino protonated residue

[Term]
id: MOD:01802
name: N,N,N-trimethyl-L-serine (from L-serinium)
def: "A protein modification that effectively converts an L-serinium (protonated L-serine) residue to an N,N,N-trimethyl-L-serine." [PubMed:18688235]
comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ser process (MOD:00071) accounts for both protonation and trimethylation.
subset: PSI-MOD-slim
synonym: "N2Me3Ala" EXACT PSI-MOD-label []
xref: DiffAvg: "42.08"
xref: DiffFormula: "C 3 H 6 N 0 O 0"
xref: DiffMono: "42.046402"
xref: FormalCharge: "1+"
xref: Formula: "C 6 H 13 N 1 O 2"
xref: MassAvg: "131.17"
xref: MassMono: "131.094080"
xref: Origin: "MOD:01801"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:01687 ! alpha-amino trimethylated residue
relationship: derives_from MOD:01801 ! protonated L-serine (L-serinium) residue

[Term]
id: MOD:01803
name: O-methylated threonine
def: "A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine or L-threonine methyl ester." [PubMed:18688235]
synonym: "OMeThr" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00393 ! O-methylated residue
is_a: MOD:01418 ! methylated threonine

[Term]
id: MOD:01804
name: glycosylphosphorylated residue
def: "A protein modification that effectively results from forming an adduct with a glycosylphosphate through a phosphodiester bond." [PubMed:18688235]
is_a: MOD:00764 ! glycoconjugated residue
is_a: MOD:00861 ! phosphorus containing modified residue

[Term]
id: MOD:01805
name: N-(L-isoaspartyl)-glycine (Asp)
def: "A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)-glycine and the release of water." [ChEBI:21479, PubMed:1826288, PubMed:18671394, RESID:AA0126]
comment: Cross-link 2.
synonym: "(2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "2-amino-N4-(carboxymethyl)-butanediamic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Asp-Gly)" EXACT UniProt-feature []
synonym: "CROSSLNK Isoaspartyl glycine isopeptide (Gly-Asp)" EXACT UniProt-feature []
synonym: "isoaspartyl glycine" EXACT RESID-alternate []
synonym: "N-(L-isoaspartyl)-glycine" EXACT RESID-name []
synonym: "N-beta-aspartylglycine" EXACT RESID-alternate []
synonym: "N4-(carboxymethyl)-asparagine" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 6 H 7 N 2 O 3"
xref: MassAvg: "155.13"
xref: MassMono: "155.045667"
xref: Origin: "D, G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0490
is_a: MOD:02043 ! crosslinked L-aspartic acid residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01928 ! N-(L-isoaspartyl)-glycine

[Term]
id: MOD:01806
name: N,N-dimethyl-L-leucine
def: "A protein modification that effectively converts an L-leucine residue to N,N-dimethyl-L-leucine." [PubMed:19522542, RESID:AA0538]
synonym: "(2S)-2-(dimethylamino)-4-methylpentanoic acid" EXACT RESID-systematic []
synonym: "2-(dimethylamino)-4-methylvaleric acid" EXACT RESID-alternate []
synonym: "2-(dimethylazanyl)-4-methylpentanoic acid" EXACT RESID-alternate []
synonym: "MOD_RES N,N-dimethylleucine" EXACT UniProt-feature []
synonym: "N,N-dimethyl-L-leucine" EXACT RESID-name []
synonym: "N,N-dimethylleucine" EXACT RESID-alternate []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4 N 0 O 0"
xref: DiffMono: "28.031300"
xref: Formula: "C 8 H 16 N 1 O 1"
xref: MassAvg: "142.22"
xref: MassMono: "142.123189"
xref: Origin: "L"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0435
is_a: MOD:01686 ! alpha-amino dimethylated residue
is_a: MOD:01808 ! N-methylated leucine

[Term]
id: MOD:01807
name: N-formyl-L-glutamic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to N-formyl-L-glutamic acid." [PubMed:18001127, RESID:AA0539]
synonym: "(2S)-2-(formylamino)pentanedioic acid" EXACT RESID-systematic []
synonym: "2-(formylazanyl)pentanedioic acid" EXACT RESID-alternate []
synonym: "2-formamidopentanedioic acid" EXACT RESID-alternate []
synonym: "2-formylaminopentanedioic acid" EXACT RESID-alternate []
synonym: "N-formyl-L-glutamic acid" EXACT RESID-name []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 H 0 N 0 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "C 6 H 8 N 1 O 4"
xref: MassAvg: "158.13"
xref: MassMono: "158.045333"
xref: Origin: "E"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00409 ! N-formylated residue
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:01808
name: N-methylated leucine
def: "A protein modification that effectively replaces an L-leucine alpha amino hydrogen with a methyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "MeLeu" EXACT PSI-MOD-label []
xref: Origin: "L"
is_a: MOD:00662 ! methylated leucine
is_a: MOD:01460 ! alpha-amino methylated residue

[Term]
id: MOD:01809
name: 5x(13)C,1x(15)N labeled residue
def: "A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C,1x(15)N labeled residue." [PubMed:12771378, Unimod:268]
synonym: "13C(5) 15N(1) Silac label" RELATED Unimod-description []
synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label []
xref: DiffAvg: "6.01"
xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1"
xref: DiffMono: "6.013809"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:268"
is_a: MOD:00842 ! (13)C labeled residue
is_a: MOD:00843 ! (15)N labeled residue

[Term]
id: MOD:01810
name: 5x(13)C,1x(15)N labeled L-proline
def: "A protein modification that effectively converts an L-proline residue to 5x(13)C,1x(15)N labeled L-proline." [PubMed:12771378, Unimod:268#P]
synonym: "13C(5) 15N(1) Silac label" RELATED Unimod-description []
synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label []
xref: DiffAvg: "6.01"
xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1"
xref: DiffMono: "6.013809"
xref: Formula: "(13)C 5 H 7 (15)N 1 O 1"
xref: MassAvg: "103.07"
xref: MassMono: "103.066573"
xref: Origin: "P"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:268"
is_a: MOD:00915 ! modified L-proline residue
is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue

[Term]
id: MOD:01811
name: 5x(13)C,1x(15)N labeled L-methionine
def: "A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine." [PubMed:12771378, Unimod:268#M]
synonym: "13C(5) 15N(1) Silac label" RELATED Unimod-description []
synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label []
xref: DiffAvg: "6.01"
xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1"
xref: DiffMono: "6.013809"
xref: Formula: "(13)C 5 H 9 (15)N 1 O 1 S 1"
xref: MassAvg: "137.05"
xref: MassMono: "137.054294"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:268"
is_a: MOD:00913 ! modified L-methionine residue
is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue

[Term]
id: MOD:01812
name: 5x(13)C,1x(15)N labeled L-methionine sulfoxide
def: "A protein modification that effectively converts an L-methionine residue to 5x(13)C,1x(15)N labeled L-methionine sulfoxide." [PubMed:12771378, Unimod:268#M]
synonym: "13C(5) 15N(1) Silac label" RELATED Unimod-description []
synonym: "Label:13C(5)15N(1)" RELATED PSI-MS-label []
xref: DiffAvg: "6.01"
xref: DiffFormula: "(12)C -5 (13)C 5 (14)N -1 (15)N 1"
xref: DiffMono: "6.013809"
xref: Formula: "(13)C 5 H 9 (15)N 1 O 2 S 1"
xref: MassAvg: "153.05"
xref: MassMono: "153.049209"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:268"
relationship: derives_from MOD:00719 ! L-methionine sulfoxide
is_a: MOD:01809 ! 5x(13)C,1x(15)N labeled residue

[Term]
id: MOD:01813
name: morpholine-2-acetylated residue
def: "A protein modification that effectively substitutes a morpholine-2-acetyl group for a hydrogen atom." [PubMed:10446193, Unimod:29]
comment: The Unimod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG].
synonym: "N-Succinimidyl-2-morpholine acetate" RELATED Unimod-description []
synonym: "N-succinimidylmorpholine-2-acetate derivative" EXACT PSI-MOD-alternate []
synonym: "SMA" RELATED PSI-MS-label []
xref: DiffAvg: "127.14"
xref: DiffFormula: "C 6 H 9 N 1 O 2"
xref: DiffMono: "127.063329"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: Unimod: "Unimod:29"
is_a: MOD:00649 ! acylated residue
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01814
name: L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid
def: "A protein modification that effectively cross-links a cysteine and two serine residues to form L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid." [PubMed:18406324, PubMed:19678698, PubMed:893891, RESID:AA0540]
comment: Cross-link 3.
synonym: "6-[(1R)-1-amino-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid" EXACT RESID-systematic []
synonym: "6-[1-azanyl-2-sulfanylethyl]-3-hydroxypyridine-2,5-dicarboxylic acid" EXACT RESID-alternate []
synonym: "L-cysteine 3-hydroxy-2,5-pyridinedicarboxylic acid" EXACT RESID-name []
synonym: "CROSSLNK 3-hydroxypyridine-2,5-dicarboxylic acid (Ser-Cys)" RELATED UniProt-feature []
xref: DiffAvg: "-54.07"
xref: DiffFormula: "C 0 H -8 N -1 O -2 S 0"
xref: DiffMono: "-54.055504"
xref: Formula: "C 9 H 7 N 2 O 3 S 1"
xref: MassAvg: "223.23"
xref: MassMono: "223.017738"
xref: Origin: "C, S, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0454
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01425 ! pyridinyl ring crosslinked residues

[Term]
id: MOD:01815
name: L-glutamate thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamic acid residue to form L-glutamate thiazole-4-carboxylic acid." [PubMed:18406324, PubMed:19678698, PubMed:893891, RESID:AA0541]
comment: Cross-link 2.
synonym: "2-[(1S)-1-amino-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[-1-azanyl-3-carboxypropyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Thiazole-4-carboxylic acid (Glu-Cys)" EXACT UniProt-feature []
synonym: "L-glutamate thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 8 H 8 N 2 O 3 S 1"
xref: MassAvg: "212.22"
xref: MassMono: "212.025563"
xref: Origin: "C, E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0456
is_a: MOD:02045 ! crosslinked L-glutamic acid residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01816
name: 2'-hydroxy-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to a 2'-hydroxy-L-tryptophan." [PubMed:11714714, RESID:AA0542]
synonym: "(2S)-2-amino-3-(2-hydroxy-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "2'-hydroxy-L-tryptophan" EXACT RESID-name []
synonym: "2-azanyl-3-(2-hydroxy-1H-indol-3-yl)propanoic acid" EXACT RESID-alternate []
synonym: "2-hydroxy-L-tryptophan" EXACT RESID-alternate []
synonym: "2-hydroxy-tryptophan" EXACT RESID-alternate []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 11 H 10 N 2 O 2"
xref: MassAvg: "202.21"
xref: MassMono: "202.074228"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01622 ! monohydroxylated tryptophan

[Term]
id: MOD:01817
name: 2'-oxo-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to a 2'-oxo-L-tryptophan." [PubMed:9461080, RESID:AA0543]
synonym: "(2S)-2-amino-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid" EXACT RESID-systematic []
synonym: "2'-oxo-L-tryptophan" EXACT RESID-name []
synonym: "2-azanyl-3-[(3S)-2-oxo-2,3-dihydro-1H-indol-3-yl]propanoic acid" EXACT RESID-alternate []
synonym: "2-oxo-L-tryptophan" EXACT RESID-alternate []
synonym: "2-oxotryptophan" EXACT RESID-alternate []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 11 H 10 N 2 O 2"
xref: MassAvg: "202.21"
xref: MassMono: "202.074228"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00679 ! carbon oxygenated residue
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:01818
name: 1'-(L-tryptophan-3'-yl)-L-tryptophan
def: "A protein modification that effectively cross-links two tryptophan residues to form 1'-(L-tryptophan-3'-yl)-L-tryptophan." [PubMed:20600836, RESID:AA0544]
comment: Cross-link 2.
synonym: "(2S,2'S)-3,3'-(3'H-1,3'-biindole-3,3'-diyl)bis(2-aminopropanoic acid)" EXACT RESID-alternate []
synonym: "1-(L-tryptophan-3-yl)-L-tryptophan" EXACT RESID-name []
synonym: "2-amino-3-[2-[2-amino-3-(2-carboxyethyl)-1H-indol-4-yl]-1H-indol-3-yl]propanoic acid" EXACT RESID-alternate []
synonym: "3-[(2S)-2-amino-2-carboxyethyl]-3-(3-[(2S)-2-amino-2-carboxyethyl]-1H-indol-2-yl)-1H-indole" EXACT RESID-systematic []
synonym: "3-[2-azanyl-2-carboxyethyl]-3-(3-[2-azanyl-2-carboxyethyl]-1H-indol-2-yl)-1H-indole" EXACT RESID-alternate []
synonym: "ditryptophan" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 22 H 18 N 4 O 2"
xref: MassAvg: "370.41"
xref: MassMono: "370.142976"
xref: Origin: "W, W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0544
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02057 ! crosslinked L-tryptophan residue

[Term]
id: MOD:01819
name: N6-succinyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-succinyl-L-lysine." [PubMed:16582421, PubMed:21151122, RESID:AA0545]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-6-[(3-carboxypropanoyl)amino]hexanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-6-[(3-carboxypropanoyl)azanyl]hexanoic acid" EXACT RESID-alternate []
synonym: "4-[[(5S)-5-amino-6-hydroxy-6-oxohexyl]amino]-4-oxobutanoate" EXACT RESID-alternate []
synonym: "MOD_RES N6-succinyllysine" EXACT UniProt-feature []
synonym: "N(epsilon)-(succinyl)lysine" EXACT RESID-alternate []
synonym: "N6-succinyl-L-lysine" EXACT RESID-name []
synonym: "succinyllysine" EXACT RESID-alternate []
xref: DiffAvg: "100.07"
xref: DiffFormula: "C 4 H 4 N 0 O 3"
xref: DiffMono: "100.016044"
xref: Formula: "C 10 H 16 N 2 O 4"
xref: MassAvg: "228.25"
xref: MassMono: "228.111007"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0438
is_a: MOD:01029 ! succinylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01820
name: isotope tagged sufhydryl reagent modified cysteine
def: "A protein modification that effectively replaces a cysteine sulhydryl hydrogen with an isotope tagged sulfhydryl reagent group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:01821
name: cysTMT6plex reporter+balance reagent cysteine disulfide
def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex reporter+balance group." [Unimod:985, URL:http\://www.piercenet.com/files/2162220.pdf]
comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "cysTMT6plex" RELATED Unimod-interim []
synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:985"
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01429 ! (15)N isotope tagged reagent
is_a: MOD:01820 ! isotope tagged sufhydryl reagent modified cysteine

[Term]
id: MOD:01822
name: cysTMT6plex-zero reporter+balance reagent cysteine disulfide
def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-zero reporter+balance group." [Unimod:984, URL:http\://www.piercenet.com/files/2162220.pdf]
comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "cysTMT" RELATED Unimod-interim []
synonym: "Native cysteine-reactive Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "299.17"
xref: DiffFormula: "(12)C 14 H 25 (14)N 3 O 2 S 1"
xref: DiffMono: "299.166748"
xref: Formula: "(12)C 17 H 32 (14)N 4 O 4 S 2"
xref: MassAvg: "420.19"
xref: MassMono: "420.186498"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:984"
is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01823
name: cysTMT6plex-126 reporter+balance reagent cysteine disulfide
def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-126 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf]
comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "cysTMT6plex" RELATED Unimod-interim []
synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.18"
xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1"
xref: DiffMono: "304.177202"
xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2"
xref: MassAvg: "425.20"
xref: MassMono: "425.196952"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:985"
is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01824
name: cysTMT6plex-127 reporter+balance reagent cysteine disulfide
def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-127 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf]
comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "cysTMT6plex" RELATED Unimod-interim []
synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.18"
xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1"
xref: DiffMono: "304.177202"
xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2"
xref: MassAvg: "425.20"
xref: MassMono: "425.196952"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01825
name: cysTMT6plex-128 reporter+balance reagent cysteine disulfide
def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-128 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf]
comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "cysTMT6plex" RELATED Unimod-interim []
synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.18"
xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1"
xref: DiffMono: "304.177202"
xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2"
xref: MassAvg: "425.20"
xref: MassMono: "425.196952"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01826
name: cysTMT6plex-129 reporter+balance reagent cysteine disulfide
def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-129 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf]
comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "cysTMT6plex" RELATED Unimod-interim []
synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.18"
xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1"
xref: DiffMono: "304.177202"
xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2"
xref: MassAvg: "425.20"
xref: MassMono: "425.196952"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01827
name: cysTMT6plex-130 reporter+balance reagent cysteine disulfide
def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-130 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf]
comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "cysTMT6plex" RELATED Unimod-interim []
synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.18"
xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1"
xref: DiffMono: "304.177202"
xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2"
xref: MassAvg: "425.20"
xref: MassMono: "425.196952"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01828
name: cysTMT6plex-131 reporter+balance reagent cysteine disulfide
def: "A protein modification that effectively replaces a residue sulfhydryl hydrogen with a Thermo Scientific cysTMT6plex-131 reporter+balance group." [PubMed:18688235, URL:http\://www.piercenet.com/files/2162220.pdf]
comment: The reagent consists of a reporter group, a balance group and a protein sulfhydryl reactive pyridine disulfanyl group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "cysteine-reactive Sixplex Tandem Mass Tag(TM)" RELATED Unimod-description []
synonym: "cysTMT6plex" RELATED Unimod-interim []
synonym: "S-(2-{3-[2-(2,6-dimethylpiperidin-1-yl)acetamido]propanamido}ethyl)sulfanyl" EXACT PSI-MOD-alternate []
xref: DiffAvg: "304.18"
xref: DiffFormula: "(12)C 10 (13)C 4 H 25 (14)N 2 (15)N 1 O 2 S 1"
xref: DiffMono: "304.177202"
xref: Formula: "(12)C 13 (13)C 4 H 32 (14)N 3 (15)N 1 O 4 S 2"
xref: MassAvg: "425.20"
xref: MassMono: "425.196952"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01821 ! cysTMT6plex reporter+balance reagent cysteine disulfide

[Term]
id: MOD:01829
name: S-carboxymethyl-L-cysteine sulfoxide
def: "A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfoxide." [PubMed:17689096, PubMed:18688235]
synonym: "CmCO" EXACT PSI-MOD-alternate []
xref: DiffAvg: "58.04"
xref: DiffFormula: "C 2 H 2 N 0 O 2 S 0"
xref: DiffMono: "58.005479"
xref: Formula: "C 5 H 7 N 1 O 3 S 1"
xref: MassAvg: "161.18"
xref: MassMono: "161.014664"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00399 ! iodoacetic acid derivatized residue
is_a: MOD:00708 ! sulfur oxygenated L-cysteine
is_a: MOD:01854 ! sulfur monooxygenated residue
relationship: derives_from MOD:01061 ! S-carboxymethyl-L-cysteine

[Term]
id: MOD:01830
name: S-carboxymethyl-L-cysteine sulfone
def: "A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine sulfone." [PubMed:18688235]
synonym: "CmCO2" EXACT PSI-MOD-label []
xref: DiffAvg: "74.03"
xref: DiffFormula: "C 2 H 2 N 0 O 3 S 0"
xref: DiffMono: "74.000394"
xref: Formula: "C 5 H 7 N 1 O 4 S 1"
xref: MassAvg: "177.17"
xref: MassMono: "177.009579"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00708 ! sulfur oxygenated L-cysteine
is_a: MOD:01855 ! sulfur dioxygenated residue
relationship: derives_from MOD:01061 ! S-carboxymethyl-L-cysteine

[Term]
id: MOD:01831
name: S-carboxamidomethyl-L-cysteine sulfone
def: "A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine sulfone." [PubMed:18688235]
synonym: "CamCO2" EXACT PSI-MOD-label []
synonym: "S-carbamoylmethyl-L-cysteine sulfone" EXACT PSI-MOD-alternate []
xref: DiffAvg: "89.05"
xref: DiffFormula: "C 2 H 3 N 1 O 3"
xref: DiffMono: "89.011293"
xref: Formula: "C 5 H 8 N 2 O 4 S 1"
xref: MassAvg: "192.19"
xref: MassMono: "192.020478"
xref: Origin: "C"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00708 ! sulfur oxygenated L-cysteine
is_a: MOD:01855 ! sulfur dioxygenated residue
relationship: derives_from MOD:01060 ! S-carboxamidomethyl-L-cysteine

[Term]
id: MOD:01832
name: 5x(13)C-labeled residue
def: "A protein modification that effectively converts a residue containing common isotopes to a 5x(13)C-labeled residue." [PubMed:12771378, Unimod:772]
synonym: "13C(5) Silac label" RELATED Unimod-description []
synonym: "Label:13C(5)" RELATED PSI-MS-label []
xref: DiffAvg: "5.02"
xref: DiffFormula: "(12)C -5 (13)C 5"
xref: DiffMono: "5.016774"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:772"
is_a: MOD:00842 ! (13)C labeled residue

[Term]
id: MOD:01833
name: 5x(13)C-labeled L-methionine
def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine." [PubMed:18688235, url:]
xref: DiffAvg: "5.02"
xref: DiffFormula: "(12)C -5 (13)C 5 H 0 N 0 O 0 S 0"
xref: DiffMono: "5.016774"
xref: Formula: "(13)C 5 H 9 N 1 O 1 S 1"
xref: MassAvg: "136.06"
xref: MassMono: "136.057259"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00913 ! modified L-methionine residue
is_a: MOD:01832 ! 5x(13)C-labeled residue

[Term]
id: MOD:01834
name: 5x(13)C-labeled L-methionine sulfoxide
def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfoxide." [PubMed:18688235]
xref: DiffAvg: "5.02"
xref: DiffFormula: "(12)C -5 (13)C 5 H 0 N 0 O 0 S 0"
xref: DiffMono: "5.016774"
xref: Formula: "(13)C 5 H 9 N 1 O 2 S 1"
xref: MassAvg: "152.05"
xref: MassMono: "152.052174"
xref: Origin: "MOD:00719"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:00719 ! L-methionine sulfoxide
is_a: MOD:01832 ! 5x(13)C-labeled residue

[Term]
id: MOD:01835
name: 5x(13)C-labeled L-methionine sulfone
def: "A protein modification that effectively converts an L-methionine residue containing common isotopes to 5x(13)C-labeled L-methionine sulfone." [PubMed:18688235]
xref: DiffAvg: "5.02"
xref: DiffFormula: "(12)C -5 (13)C 5 H 0 N 0 O 0 S 0"
xref: DiffMono: "5.016774"
xref: Formula: "(13)C 5 H 9 N 1 O 3 S 1"
xref: MassAvg: "168.05"
xref: MassMono: "168.047088"
xref: Origin: "MOD:00256"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:00256 ! L-methionine sulfone
is_a: MOD:01832 ! 5x(13)C-labeled residue

[Term]
id: MOD:01836
name: N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-[([1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethoxy]carbonyl]lysine." [PubMed:18688235, PubMed:20218600, PubMed:21271704]
synonym: "(2S)-2-amino-6-[([1-(6-nitro-1,3-benzodioxol-5-yl)ethoxy]carbonyl)amino]hexanoic acid" EXACT PSI-MOD-alternate []
synonym: "[(alpha-methyl-6-nitro-piperonyloxy)carbonyl]lysine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "237.17"
xref: DiffFormula: "C 10 H 7 N 1 O 6"
xref: DiffMono: "237.027337"
xref: Formula: "C 16 H 19 N 3 O 7"
xref: MassAvg: "365.34"
xref: MassMono: "365.122300"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00848 ! reagent derivatized residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01837
name: L-lanthionine (Cys-Cys)
def: "A protein modification that effectively cross-links two L-cysteine residues with a thioether bond to form L-lanthionine." [ChEBI:21347, PubMed:20805503, PubMed:6007887, RESID:AA0110#CYS2]
comment: Cross-link 2.
synonym: "(2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid)" EXACT RESID-systematic []
synonym: "(R)-S-(2-amino-2-carboxyethyl)-L-cysteine" EXACT RESID-alternate []
synonym: "(R,R)-2,6-diamino-4-thiaheptanedioic acid" EXACT RESID-alternate []
synonym: "(R,R)-3,3'-thiobis-(2-aminopropanoic acid)" EXACT RESID-alternate []
synonym: "(R,R)-bis(2-amino-2-carboxyethyl)sulfide" EXACT RESID-alternate []
synonym: "2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid" EXACT RESID-alternate []
synonym: "3,3'-thiobis-L-alanine" EXACT RESID-alternate []
synonym: "L-lanthionine" EXACT RESID-name []
xref: DiffAvg: "-34.08"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1"
xref: DiffMono: "-33.987721"
xref: Formula: "C 6 H 8 N 2 O 2 S 1"
xref: MassAvg: "172.20"
xref: MassMono: "172.030649"
xref: Origin: "C, C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00687 ! thioether crosslinked residues

[Term]
id: MOD:01838
name: L-lysinoalanine (Lys)
def: "A protein modification that effectively converts an L-lysine residue to L-lysinoalanine." [PubMed:19155267, PubMed:2544544, RESID:AA0123#LYS]
comment: This entry is for the modification of peptidyl lysine by a free serine. For the crosslink of peptidyl serine and peptidyl lysine see MOD:00132.
synonym: "(2R,9S)-lysinoalanine" EXACT RESID-alternate []
synonym: "(2S)-2-amino-6-([(2R)-2-amino-2-carboxyethyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "alaninolysine" EXACT RESID-alternate []
synonym: "L-lysinoalanine" EXACT RESID-name []
synonym: "LAL" EXACT RESID-alternate []
synonym: "lysino-D-alanine" EXACT RESID-alternate []
synonym: "MOD_RES Lysino-D-alanine (Lys)" EXACT UniProt-feature []
synonym: "N-epsilon-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate []
synonym: "N6-(2-amino-2-carboxyethyl)-L-lysine" EXACT RESID-alternate []
xref: DiffAvg: "87.08"
xref: DiffFormula: "C 3 H 5 N 1 O 2"
xref: DiffMono: "87.032028"
xref: Formula: "C 9 H 17 N 3 O 3"
xref: MassAvg: "215.25"
xref: MassMono: "215.126991"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0439
is_a: MOD:01853 ! L-lysinoalanine

[Term]
id: MOD:01839
name: L-lanthionine
def: "A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine." [PubMed:18688235]
comment: Cross-link 2. For the natural form of the lanthionine cross-link see MOD:00120 meso-lanthionine [JSG].
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 6 H 8 N 2 O 2 S 1"
xref: MassAvg: "172.20"
xref: MassMono: "172.030649"
xref: Origin: "C, X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:01841 ! lanthionine
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01840
name: L-allo-isoleucine
def: "A protein modification that effectively converts an L-isoleucine residue to L-allo-isoleucine." [ChEBI:43433, PubMed:20805503, RESID:AA0546]
synonym: "(2S,3R)-2-amino-3-methylpentanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-3-methylpentanoic acid" EXACT RESID-alternate []
synonym: "3-methyl-norvaline" EXACT RESID-alternate []
synonym: "allo-L-isoleucine" EXACT RESID-alternate []
synonym: "alpha-amino-beta-methylvaleric acid" EXACT RESID-alternate []
synonym: "L-allo-isoleucine" EXACT RESID-name []
synonym: "L-threo-isoleucine" EXACT RESID-alternate []
synonym: "MOD_RES L-allo-isoleucine" EXACT UniProt-feature []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 6 H 11 N 1 O 1"
xref: MassAvg: "113.16"
xref: MassMono: "113.084064"
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0442
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:00910 ! modified L-isoleucine residue
is_a: MOD:00306 ! residues isobaric at 113.084064 Da

[Term]
id: MOD:01841
name: lanthionine
def: "A protein modification that effectively cross-links either two or an L-cysteine residue and an L-serine residue by a thioether bond to form a lanthionine, either D- or L- or meso-lanthionine." [PubMed:18688235]
comment: Cross-link 2. [JSG].
synonym: "2,6-diamino-4-thiaheptanedioic acid" EXACT PSI-MOD-alternate []
synonym: "2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid" EXACT PSI-MOD-alternate []
synonym: "3,3'-thiobis-(2-aminopropanoic acid)" EXACT PSI-MOD-alternate []
synonym: "3,3'-thiobis-L-alanine" EXACT PSI-MOD-alternate []
synonym: "bis(2-amino-2-carboxyethyl)sulfanediyl" EXACT PSI-MOD-alternate []
synonym: "bis(2-amino-2-carboxyethyl)sulfide" EXACT PSI-MOD-alternate []
synonym: "S-(2-amino-2-carboxyethyl)-L-cysteine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 6 H 8 N 2 O 2 S 1"
xref: MassAvg: "172.20"
xref: MassMono: "172.030649"
xref: Origin: "C, X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01993 ! beta-carbon thioether crosslinked residues
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01842
name: S-(2-aminovinyl)-L-cysteine
def: "A protein modification that effectively converts two L-cysteine residues to S-(2-aminovinyl)-L-cysteine." [PubMed:20805503, RESID:AA0548]
comment: Cross-link 2.
synonym: "(2R)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "(R,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate []
synonym: "S-(2-aminovinyl)-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "-80.10"
xref: DiffFormula: "C -1 H -4 N 0 O -2 S -1"
xref: DiffMono: "-79.993200"
xref: Formula: "C 5 H 7 N 2 O 1 S 1"
xref: MassAvg: "143.18"
xref: MassMono: "143.027909"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0443
is_a: MOD:01851 ! S-(2-aminovinyl)-cysteine

[Term]
id: MOD:01843
name: 5'-chloro-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to 5'-chloro-L-tryptophan." [PubMed:18215770, RESID:AA0549]
synonym: "(2S)-2-amino-3-(5-chloro-1H-indol-3-yl)propanoic acid" EXACT RESID-systematic []
synonym: "5'-chloro-L-tryptophan" EXACT RESID-name []
synonym: "MOD_RES 5'-chlorotryptophan" EXACT UniProt-feature []
xref: DiffAvg: "34.44"
xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0"
xref: DiffMono: "33.961028"
xref: Formula: "C 11 Cl 1 H 9 N 2 O 1"
xref: MassAvg: "220.66"
xref: MassMono: "220.040341"
xref: Origin: "W"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0444
is_a: MOD:01913 ! monochlorinated L-tryptophan

[Term]
id: MOD:01844
name: 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid
def: "A protein modification that effectively converts an L-cysteine residue and an L-leucine residue to 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid." [PubMed:15361623, PubMed:18729522, PubMed:20961038, PubMed:21254756, RESID:AA0550]
comment: Cross-link 2.
synonym: "(4Z)-4-[hydroxy(sulfanyl)methylidene]-2-(3-methylbutanoyl)-1,3-oxazol-5(4H)-one [tautomer]" EXACT RESID-alternate []
synonym: "2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid" EXACT RESID-name []
synonym: "5-hydroxy-2-(3-methylbutanoyl)-1,3-oxazole-4-carbothioic O-acid" EXACT RESID-systematic []
synonym: "MOD_RES 2-(3-methylbutanoyl)-5-hydroxyoxazole-4-carbothionic acid (Leu-Cys)" EXACT UniProt-feature []
xref: DiffAvg: "-5.06"
xref: DiffFormula: "C 0 H -7 N -1 O 1 S 0"
xref: DiffMono: "-5.062935"
xref: Formula: "C 9 H 10 N 1 O 3 S 1"
xref: MassAvg: "212.24"
xref: MassMono: "212.038139"
xref: Origin: "C, L"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0448
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02050 ! crosslinked L-leucine residue
is_a: MOD:01856 ! oxazole/oxazoline ring crosslinked residues (Cys)

[Term]
id: MOD:01845
name: L-proline 5-hydroxyoxazole-4-carbothionic acid
def: "A protein modification that effectively converts an L-cysteine residue and an L-proline residue to L-proline 5-hydroxyoxazole-4-carbothionic acid." [PubMed:15361623, PubMed:18729522, PubMed:20961038, PubMed:21254756, RESID:AA0551]
comment: Cross-link 2.
synonym: "(4Z)-4-[hydroxy(sulfanyl)methylidene]-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazol-5(4H)-one [tautomer]" EXACT RESID-alternate []
synonym: "5-hydroxy-2-[(2S)-pyrrolidin-2-yl]-1,3-oxazole-4-carbothioic O-acid" EXACT RESID-systematic []
synonym: "CROSSLNK Proline 5-hydroxy-oxazole-4-carbothionic acid (Pro-Cys)" EXACT UniProt-feature []
synonym: "L-proline 5-hydroxy-oxazole-4-carbothionic acid" EXACT RESID-name []
xref: DiffAvg: "-4.03"
xref: DiffFormula: "C 0 H -4 N 0 O 0 S 0"
xref: DiffMono: "-4.031300"
xref: Formula: "C 8 H 8 N 2 O 2 S 1"
xref: MassAvg: "196.22"
xref: MassMono: "196.030649"
xref: Origin: "C, P"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0449
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02054 ! crosslinked L-proline residue
is_a: MOD:01856 ! oxazole/oxazoline ring crosslinked residues (Cys)

[Term]
id: MOD:01846
name: methanobactin OB3b copper complex
def: "A protein modification that effectively converts two L-cysteine residues, and a copper atom to the methanobactin OB3b copper complex." [PubMed:15361623, PubMed:18729522, PubMed:20961038, PubMed:21254756, RESID:AA0552]
comment: Cross-link 2.
synonym: "bis[4-(hydroxy[sulfanyl-kappaS]methylidene)-1,3-oxazol-5(4H)-onato-kappaN]copper" EXACT RESID-systematic []
synonym: "METAL copper [Cu-methanobactin OB3b complex]" EXACT UniProt-feature []
synonym: "methanobactin OB3b copper complex" EXACT RESID-name []
xref: DiffAvg: "85.46"
xref: DiffFormula: "C 0 Cu 1 H -10 N 0 O 2 S 0"
xref: DiffMono: "84.841176"
xref: Formula: "C 6 Cu 1 H 0 N 2 O 4 S 2"
xref: MassAvg: "291.74"
xref: MassMono: "290.859546"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00742 ! copper containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:01847
name: L-cysteine sulfinyl phosphate
def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine sulfinyl phosphate." [PubMed:16565085, RESID:AA0557]
synonym: "(2R)-2-amino-3-[(phosphonooxy)sulfinyl]propanoic acid" EXACT RESID-systematic []
synonym: "cysteine sulfinic phosphoryl ester" EXACT RESID-alternate []
synonym: "L-cysteine sulfinyl phosphate" EXACT RESID-name []
xref: DiffAvg: "111.98"
xref: DiffFormula: "C 0 H 1 N 0 O 5 P 1 S 0"
xref: DiffMono: "111.956160"
xref: Formula: "C 3 H 6 N 1 O 6 P 1 S 1"
xref: MassAvg: "215.12"
xref: MassMono: "214.965345"
xref: Origin: "C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00708 ! sulfur oxygenated L-cysteine
is_a: MOD:00861 ! phosphorus containing modified residue

[Term]
id: MOD:01848
name: S-(spermidinoglutathion-S-yl)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(spermidinoglutathion-S-yl)-L-cysteine." [ChEBI:16613, PubMed:20530482, RESID:AA0558]
synonym: "(2R)-2-amino-3-([(2R)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)-2-([2-([3-([4-aminobutyl]amino)propyl]carbamoyl)methyl]carbamoyl)ethyl]disulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "cysteine glutathionylspermidine disulfide" EXACT RESID-alternate []
synonym: "L-gamma-glutamyl-[S-(L-cystein-S-yl)]-L-cysteinyl-N-{3-[(4-aminobutyl)amino]propyl}glycinamide" EXACT RESID-alternate []
synonym: "S-(spermidinoglutathion-S-yl)-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "432.54"
xref: DiffFormula: "C 17 H 32 N 6 O 5 S 1"
xref: DiffMono: "432.215489"
xref: Formula: "C 20 H 37 N 7 O 6 S 2"
xref: MassAvg: "535.68"
xref: MassMono: "535.224674"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01862 ! disulfide conjugated residue

[Term]
id: MOD:01849
name: S-(2-aminovinyl)-D-cysteine (Cys-Cys)
def: "A protein modification that effectively cross-links two L-cysteine residues by a thioether bond to form S-(2-aminovinyl)-D-cysteine." [PubMed:20805503, RESID:AA0204#CYS2]
comment: Cross-link 2.
synonym: "(2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "(S,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate []
synonym: "CROSSLNK S-(2-aminovinyl)-D-cysteine (Cys-Cys)" EXACT UniProt-feature []
synonym: "S-(2-aminovinyl)-D-cysteine" EXACT RESID-name []
xref: DiffAvg: "-80.10"
xref: DiffFormula: "C -1 H -4 N 0 O -2 S -1"
xref: DiffMono: "-79.993200"
xref: Formula: "C 5 H 7 N 2 O 1 S 1"
xref: MassAvg: "143.18"
xref: MassMono: "143.027909"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "C-term"
xref: uniprot.ptm:PTM-0446
is_a: MOD:01850 ! S-(2-aminovinyl)-D-cysteine

[Term]
id: MOD:01850
name: S-(2-aminovinyl)-D-cysteine
def: "A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine." [RESID:AA0204]
comment: Cross-link 2.
synonym: "(2S)-2-amino-3-([(Z)-2-aminoethenyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "(S,Z)-S-(2-aminovinyl)cysteine" EXACT RESID-alternate []
synonym: "S-(2-aminovinyl)-D-cysteine" EXACT RESID-name []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 5 H 7 N 2 O 1 S 1"
xref: MassAvg: "143.18"
xref: MassMono: "143.027909"
xref: Origin: "C, X"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:01851 ! S-(2-aminovinyl)-cysteine

[Term]
id: MOD:01851
name: S-(2-aminovinyl)-cysteine
def: "A protein modification that effectively cross-links either two L-cysteine residues, or an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-cysteine." [PubMed:18688235]
comment: Cross-link 2.
synonym: "2-amino-3-([2-aminoethenyl]sulfanyl)propanoic acid" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 5 H 7 N 2 O 1 S 1"
xref: MassAvg: "143.18"
xref: MassMono: "143.027909"
xref: Origin: "C, X"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00687 ! thioether crosslinked residues
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:01852
name: L-lysinoalanine (Lys-Cys)
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to release hydrogen sulfide and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid." [DeltaMass:0]
comment: Cross-link 2. This entry is for a crosslink of peptidyl cysteine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34 with no citation or formula. [JSG]
synonym: "Lysinoalanine (from Cysteine)" EXACT DeltaMass-label []
xref: DiffAvg: "-34.08"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S -1"
xref: DiffMono: "-33.987721"
xref: Formula: "C 9 H 15 N 3 O 2"
xref: MassAvg: "197.24"
xref: MassMono: "197.116427"
xref: Origin: "C, K"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01853 ! L-lysinoalanine

[Term]
id: MOD:01853
name: L-lysinoalanine
def: "A protein modification that effectively converts an L-lysine residue to L-lysinoalanine either by forming a cross-link with peptidyl-cysteine or peptidyl-serine, or by condensation with free serine." [PubMed:18688235]
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01854
name: sulfur monooxygenated residue
def: "A protein modification that effectively adds one oxygen atom to a sulfur atom of a residue without removing hydrogen atoms." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00680 ! sulfur oxygenated residue

[Term]
id: MOD:01855
name: sulfur dioxygenated residue
def: "A protein modification that effectively adds two oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:00680 ! sulfur oxygenated residue

[Term]
id: MOD:01856
name: oxazole/oxazoline ring crosslinked residues (Cys)
def: "A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid." [PubMed:18688235]
is_a: MOD:01419 ! oxazole/oxazoline ring crosslinked residues

[Term]
id: MOD:01857
name: 2-(L-cystein-S-yl)-methionine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-methionine residue by a thioether bond to form 2-(L-cystein-S-yl)-methionine." [PubMed:20805502, RESID:AA0559]
comment: Cross-link 2. The chirality around the methionine alpha-carbon has not been determined.
synonym: "(2R)-2-amino-2-([2-amino-2-carboxyethyl]sulfanyl)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "2-(L-cystein-S-yl)-methionine" EXACT RESID-name []
synonym: "CROSSLNK 2-(S-cysteinyl)-methionine (Cys-Met)" EXACT UniProt-feature []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 8 H 12 N 2 O 2 S 2"
xref: MassAvg: "232.32"
xref: MassMono: "232.034020"
xref: Origin: "C, M"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0495
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02052 ! crosslinked L-methionine residue
is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues

[Term]
id: MOD:01858
name: S-(N-acetylamino)glucosyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(N-acetylamino)glucosyl-L-cysteine." [ChEBI:61631, PubMed:21251913, PubMed:21395300, RESID:AA0560]
synonym: "(2R)-2-amino-3-(2-acetamido-2-deoxy-beta-D-glucopyranosylsulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD S-linked (GlcNAc) cysteine" EXACT UniProt-feature []
synonym: "S-(N-acetylamino)glucosyl-L-cysteine" EXACT RESID-name []
synonym: "S-[(N-acetylamino)glycosyl]cysteine" EXACT RESID-alternate []
synonym: "S-[beta-D-(N-acetylamino)glucopyranosyl]cysteine" EXACT RESID-alternate []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5 S 0"
xref: DiffMono: "203.079373"
xref: Formula: "C 11 H 18 N 2 O 6 S 1"
xref: MassAvg: "306.33"
xref: MassMono: "306.088557"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0628
is_a: MOD:00426 ! S-glycosylated residue
is_a: MOD:00448 ! mono-N-acetylaminoglucosylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01859
name: 4-amino-3-isothiazolidinone-L-phenylalanine
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form 4-amino-3-isothiazolidinone-L-phenylalanine." [PubMed:17502599, RESID:AA0562]
comment: Cross-link 2.
synonym: "(2S)-2-[(4R)-4-amino-3-oxo-1,2-thiazolidin-2-yl]-3-phenylpropanoic acid" EXACT RESID-systematic []
synonym: "2-(4-amino-3-oxo-isothiazolidin-2-yl)-3-phenylpropanoic acid" EXACT RESID-alternate []
synonym: "4-amino-3-isothiazolidinone-L-phenylalanine" EXACT RESID-alternate []
synonym: "CROSSLNK N,N-(cysteine-1,S-diyl)phenylalanine (Cys-Phe)" EXACT UniProt-feature []
synonym: "cysteinyl phenylalanine sulfenamide" EXACT RESID-alternate []
synonym: "N,N-(L-cysteine-1,S-diyl)-L-phenylalanine" EXACT RESID-name []
synonym: "phenylalanine-cysteine sulfenyl amide cross-link" EXACT RESID-alternate []
synonym: "phenylalanine-cysteine sulphenyl amide cross-link" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 12 H 12 N 2 O 2 S 1"
xref: MassAvg: "248.30"
xref: MassMono: "248.061949"
xref: Origin: "C, F"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0451
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02053 ! crosslinked L-phenylalanine residue
is_a: MOD:01861 ! isothiazolidinone ring crosslinked residues

[Term]
id: MOD:01860
name: L-cysteine bacillithiol disulfide
def: "A protein modification that effectively converts an L-cysteine residue to L-cysteine bacillithiol disulfide." [ChEBI:61338, PubMed:19578333, RESID:AA0563]
synonym: "(2S)-(2-[S-(L-cystein-S-yl)-L-cysteinyl]amino-2-deoxy-alpha-D-glucopyranosyloxy)-butanedioic acid" EXACT RESID-systematic []
synonym: "BSH" EXACT RESID-alternate []
synonym: "L-cysteine bacillithiol disulfide" EXACT RESID-name []
synonym: "MOD_RES S-bacillithiol cysteine disulfide" EXACT UniProt-feature []
xref: DiffAvg: "396.37"
xref: DiffFormula: "C 13 H 20 N 2 O 10 S 1"
xref: DiffMono: "396.083866"
xref: Formula: "C 16 H 25 N 3 O 11 S 2"
xref: MassAvg: "499.51"
xref: MassMono: "499.093051"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0452
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01862 ! disulfide conjugated residue

[Term]
id: MOD:01861
name: isothiazolidinone ring crosslinked residues
def: "A protein modification that crosslinks two residues by condensation of a cysteine thiol with the amido nitrogen of the following residue to form an isothiazolidinone ring." [PubMed:18688235]
comment: The isothiazolidinone ring is usually formed by the reaction of a cysteine sulfenic acid with the amido nitrogen releasing water.
is_a: MOD:00033 ! crosslinked residues

[Term]
id: MOD:01862
name: disulfide conjugated residue
def: "A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a substituted sulfanyl group, forming a disulfide bond that does not cross-link two encoded peptide chains." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "S-thiolation" EXACT PSI-MOD-alternate []
xref: Origin: "C"
xref: TermSpec: "none"
is_a: MOD:01886 ! thiolated residue

[Term]
id: MOD:01863
name: mTRAQ reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems mTRAQ reagent reporter+balance groups." [PubMed:18688235]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED Unimod-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue
is_a: MOD:01705 ! isotope tagged reagent acylated residue

[Term]
id: MOD:01864
name: mTRAQ light reporter+balance reagent acylated residue
def: "A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems mTRAQ light reporter+balance group." [Unimod:888]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED Unimod-alternate []
synonym: "mTRAQ heavy" RELATED Unimod-description []
xref: DiffAvg: "140.09"
xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1"
xref: DiffMono: "140.094963"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:888"
is_a: MOD:01863 ! mTRAQ reporter+balance reagent acylated residue
is_a: MOD:01868 ! modifications with monoisotopic mass differences that are nominally equal at 140.094963 Da

[Term]
id: MOD:01865
name: mTRAQ light reporter+balance reagent acylated N-terminal
def: "A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems mTRAQ light reporter+balance group." [OMSSA:208, Unimod:888#N-term]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED Unimod-alternate []
synonym: "mTRAQ light" RELATED Unimod-description []
synonym: "mTRAQ light on nterm" EXACT OMSSA-label []
xref: DiffAvg: "140.09"
xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1"
xref: DiffMono: "140.094963"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:888"
is_a: MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue

[Term]
id: MOD:01866
name: mTRAQ light reporter+balance reagent N6-acylated lysine
def: "A protein modification that effectively replaces the N6-amino hydrogen atom of a lysine residue with the Applied Biosystems mTRAQ light reporter+balance group." [OMSSA:209, Unimod:888#K]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED Unimod-alternate []
synonym: "mTRAQ light" RELATED Unimod-description []
synonym: "mTRAQ light on K" EXACT OMSSA-label []
xref: DiffAvg: "140.09"
xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1"
xref: DiffMono: "140.094963"
xref: Formula: "(12)C 13 H 24 N 2 (14)N 2 O 1 (16)O 1"
xref: MassAvg: "268.19"
xref: MassMono: "268.189926"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:888"
is_a: MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01867
name: mTRAQ light reporter+balance reagent O4'-acylated tyrosine
def: "A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems mTRAQ light reporter+balance group." [OMSSA:210, Unimod:888#Y]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "Applied Biosystems mTRAQ(TM) reagent" RELATED Unimod-alternate []
synonym: "mTRAQ light" RELATED Unimod-description []
synonym: "mTRAQ light on Y" EXACT OMSSA-label []
xref: DiffAvg: "140.09"
xref: DiffFormula: "(12)C 7 H 12 (14)N 2 (16)O 1"
xref: DiffMono: "140.094963"
xref: Formula: "(12)C 16 H 21 (14)N 3 O 2 (16)O 1"
xref: MassAvg: "303.16"
xref: MassMono: "303.158292"
xref: Origin: "Y"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:888"
is_a: MOD:00919 ! modified L-tyrosine residue
is_a: MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue

[Term]
id: MOD:01868
name: modifications with monoisotopic mass differences that are nominally equal at 140.094963 Da
def: "Modifications that have monoisotopic mass differences from their respective origins of 140.094963 Da." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01515 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da

[Term]
id: MOD:01869
name: mTRAQ light reporter fragment
def: "The protein modification reporter fragment produced by an Applied Biosystems mTRAQ light reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4-methyl-1-methylidenepiperazin-1-ium" EXACT PSI-MOD-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: FormalCharge: "1+"
xref: Formula: "(12)C 6 H 13 (14)N 2"
xref: MassAvg: "113.11"
xref: MassMono: "113.107325"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01870 ! mTRAQ reporter fragment
relationship: derives_from MOD:01864 ! mTRAQ light reporter+balance reagent acylated residue

[Term]
id: MOD:01870
name: mTRAQ reporter fragment
def: "A protein modification reporter fragment produced by an Applied Biosystems mTRAQ reagent derivatized residue." [PubMed:18688235]
subset: PSI-MOD-slim
is_a: MOD:01520 ! modification reporter fragment

[Term]
id: MOD:01871
name: cyclized N-terminal S-carboxamidomethyl-L-cysteine
def: "A protein modification that effectively cyclizes an S-carboxamidomethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of ammonia." [DeltaMass:336, PubMed:12643538, Unimod:26]
subset: PSI-MOD-slim
synonym: "(R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid" EXACT DeltaMass-label []
synonym: "5-oxothiomorpholine-3-carboxylic acid" EXACT PSI-MOD-alternate []
synonym: "Otc" EXACT DeltaMass-label []
synonym: "Pyro-carbamidomethyl" RELATED Unimod-interim []
synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" RELATED Unimod-description []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 5 H 6 N 1 O 2 S 1"
xref: MassAvg: "144.17"
xref: MassMono: "144.011924"
xref: Origin: "MOD:01060"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:26"
is_a: MOD:01160 ! deaminated residue
relationship: contains MOD:00419 ! (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid
relationship: derives_from MOD:01060 ! S-carboxamidomethyl-L-cysteine

[Term]
id: MOD:01872
name: cyclized N-terminal S-carboxymethyl-L-cysteine
def: "A protein modification that effectively cyclizes an S-carboxymethyl-L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid with the loss of water." [PubMed:12643538, Unimod:26]
comment: Contrary to the impression given in Unimod entry 26, the cyclization of N-terminal S-carboxymethyl-L-cysteine is not reported in PubMed:1263538. The cyclization would be expected to proceed under strongly acidic conditions [JSG].
subset: PSI-MOD-slim
synonym: "(R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid" EXACT DeltaMass-label []
synonym: "5-oxothiomorpholine-3-carboxylic acid" EXACT PSI-MOD-alternate []
synonym: "Otc" EXACT DeltaMass-label []
synonym: "Pyro-carbamidomethyl" RELATED Unimod-interim []
synonym: "S-carbamoylmethylcysteine cyclization (N-terminus)" RELATED Unimod-description []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 5 H 6 N 1 O 2 S 1"
xref: MassAvg: "144.17"
xref: MassMono: "144.011924"
xref: Origin: "MOD:01061"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:26"
is_a: MOD:00704 ! dehydrated residue
relationship: contains MOD:00419 ! (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid
relationship: derives_from MOD:01061 ! S-carboxymethyl-L-cysteine

[Term]
id: MOD:01873
name: N-carboxy-L-alanine
def: "A protein modification that effectively converts an L-alanine residue to N-carboxy-L-alanine." [PubMed:18688235, PubMed:4593770, PubMed:4647257, PubMed:8312270]
comment: This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG].
synonym: "(S)-2-carboxyamino-propanoic acid" EXACT PSI-MOD-alternate []
synonym: "2-carbamic-propanoic acid" EXACT PSI-MOD-alternate []
synonym: "N-carboxymethionine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "44.01"
xref: DiffFormula: "C 1 H 0 N 0 O 2"
xref: DiffMono: "43.989829"
xref: Formula: "C 4 H 6 N 1 O 3"
xref: MassAvg: "116.10"
xref: MassMono: "116.034768"
xref: Origin: "A"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00901 ! modified L-alanine residue
is_a: MOD:01152 ! carboxylated residue

[Term]
id: MOD:01874
name: N-carboxy-L-valine
def: "A protein modification that effectively converts an L-alanine residue to N-carboxy-L-valine." [PubMed:18688235, PubMed:4593770, PubMed:4647257, PubMed:8312270]
comment: This metastable modification can be formed by a protein N-terminal in solutions with a high concentration of dissolved carbon dioxide [JSG].
synonym: "(S)-2-carboxyamino-propanoic acid" EXACT PSI-MOD-alternate []
synonym: "2-carbamic-propanoic acid" EXACT PSI-MOD-alternate []
synonym: "N-carboxymethionine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "44.01"
xref: DiffFormula: "C 1 H 0 N 0 O 2"
xref: DiffMono: "43.989829"
xref: Formula: "C 6 H 10 N 1 O 3"
xref: MassAvg: "144.15"
xref: MassMono: "144.066068"
xref: Origin: "V"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00920 ! modified L-valine residue
is_a: MOD:01152 ! carboxylated residue

[Term]
id: MOD:01875
name: N6-acylated L-lysine
def: "A protein modification that effectively replaces an N6-amino hydrogen atom of L-lysine with an acyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "N6AcylLys" EXACT PSI-MOD-label []
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00670 ! N-acylated residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01876
name: 4x(1)H,4x(12)C-labeled alpha-amino succinylated residue
def: "OBSOLETE because identical to MOD:00457" [PubMed:18688235]
xref: DiffAvg: "100.02"
xref: DiffFormula: "(12)C 4 (1)H 4 O 3"
xref: DiffMono: "100.016044"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
xref: Remap: "MOD:00457"
is_obsolete: true

[Term]
id: MOD:01877
name: 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid
def: "A protein modification that effectively converts an L-cysteine residue and an L-arginine residue to 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid." [PubMed:20961038, RESID:AA0553]
comment: Cross-link 2.
synonym: "(4Z)-2-(4-guanidinobutanoyl)-5-oxo-4-(sulfanylmethylidene)-4,5-dihydro-1H-imidazole" EXACT RESID-alternate []
synonym: "2-(4-guanidinobutanoyl)-5-hydroxy-1H-imidazole-4-carbothioic O-acid" EXACT RESID-systematic []
synonym: "2-(4-guanidinobutanoyl)-5-hydroxy-4-thioformyl-1H-imidazole [tautomer]" EXACT RESID-alternate []
synonym: "2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid" EXACT RESID-name []
synonym: "CROSSLNK 2-(4-guanidinobutanoyl)-5-hydroxyimidazole-4-carbothionic acid (Arg-Cys)" EXACT UniProt-feature []
xref: DiffAvg: "-6.05"
xref: DiffFormula: "C 0 H -6 N 0 O 0 S 0"
xref: DiffMono: "-6.046950"
xref: Formula: "C 9 H 12 N 5 O 2 S 1"
xref: MassAvg: "254.29"
xref: MassMono: "254.071171"
xref: Origin: "C, R"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0457
is_a: MOD:02041 ! crosslinked L-arginine residue
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:01883 ! 5-imidazolinone ring crosslinked residues (Cys)

[Term]
id: MOD:01878
name: L-threonine 5-hydroxyoxazole-4-carbonthionic acid
def: "A protein modification that effectively converts an L-cysteine residue and an L-threonine residue to L-threonine 5-hydroxyoxazole-4-carbothionic acid." [PubMed:20961038, RESID:AA0554]
comment: Cross-link 2.
synonym: "(4Z)-2-[(1S,2R)-1-amino-2-hydroxypropyl]-4-(sulfanylmethylidene)-1,3-oxazol-5(4H)-one [tautomer]" EXACT RESID-alternate []
synonym: "2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-hydroxy-1,3-oxazole-4-carbothioic O-acid" EXACT RESID-systematic []
synonym: "CROSSLNK Threonine 5-hydroxy-oxazole-4-carbonthionic acid (Thr-Cys)" EXACT UniProt-feature []
synonym: "L-threonine 5-hydroxy-oxazole-4-carbonthionic acid" EXACT RESID-name []
xref: DiffAvg: "-4.03"
xref: DiffFormula: "C 0 H -4 N 0 O 0 S 0"
xref: DiffMono: "-4.031300"
xref: Formula: "C 7 H 8 N 2 O 3 S 1"
xref: MassAvg: "200.21"
xref: MassMono: "200.025563"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0458
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:01856 ! oxazole/oxazoline ring crosslinked residues (Cys)

[Term]
id: MOD:01879
name: methanobactin SB2 copper complex
def: "A protein modification that effectively converts two L-cysteine residues, an L-arginine residue, an L-threonine residue and a copper atom to the methanobactin SB2 copper complex." [PubMed:20961038, RESID:AA0555]
comment: Cross-link 2.
synonym: "[5-(hydroxy[sulfanyl-kappaS]methylene)-3,5-dihydro-4H-imidazol-4-onato-kappaN1][4-(hydroxy[sulfanyl-kappaS]methylene)-1,3-oxazol-5(4H)-onato-kappaN]copper" EXACT RESID-systematic []
synonym: "METAL copper [Cu-methanobactin SB2 complex]" EXACT UniProt-feature []
synonym: "methanobactin SB2 copper complex" EXACT RESID-name []
xref: DiffAvg: "84.48"
xref: DiffFormula: "C 0 Cu 1 H -9 N 1 O 1 S 0"
xref: DiffMono: "83.857161"
xref: Formula: "C 6 Cu 1 H 1 N 3 O 3 S 2"
xref: MassAvg: "290.76"
xref: MassMono: "289.875530"
xref: Origin: "C, C, R, T"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00742 ! copper containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:01880
name: L-deoxyhypusine
def: "modification from RESID" [ChEBI:50038, PubMed:16452303, RESID:AA0564]
synonym: "(2S)-2-amino-6-[(4-aminobutyl)amino]hexanoic acid" EXACT RESID-systematic []
synonym: "deoxyhypusine" EXACT RESID-alternate []
synonym: "L-deoxyhypusine" EXACT RESID-name []
synonym: "N6-(4-aminobutyl)lysine" EXACT RESID-alternate []
synonym: "MOD_RES Deoxyhypusine" EXACT UniProt-feature []
xref: DiffAvg: "71.12"
xref: DiffFormula: "C 4 H 9 N 1 O 0"
xref: DiffMono: "71.073499"
xref: Formula: "C 10 H 21 N 3 O 1"
xref: MassAvg: "199.30"
xref: MassMono: "199.168462"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0684
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01884 ! 4-aminobutylated residue

[Term]
id: MOD:01881
name: 3-(L-phenylalan-2'-yl)-L-valine
def: "A protein modification that effectively crosslinks an L-phenylalanine residue and an L-valine residue by a free radical process effectively releasing a hydrogen molecule and forming 3-(L-phenylalan-2'-yl)-L-valine." [PubMed:21596985, RESID:AA0565]
comment: Cross-link 2.
synonym: "(2S)-2-amino-4-(2-[(2S)-2-amino-2-carboxyethyl]phenyl)-3-methylbutanoic acid" EXACT RESID-systematic []
synonym: "3-(L-phenylalan-2'-yl)-L-valine" EXACT RESID-name []
synonym: "symerythrin valine-phenylalanine cross-link" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 14 H 16 N 2 O 2"
xref: MassAvg: "244.29"
xref: MassMono: "244.121178"
xref: Origin: "F, V"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00692 ! uncategorized crosslinked residues
is_a: MOD:02053 ! crosslinked L-phenylalanine residue
is_a: MOD:02059 ! crosslinked L-valine residue

[Term]
id: MOD:01882
name: 5-imidazolinone ring crosslinked residues (Gly)
def: "A protein modification that effectively crosslinks the carbonyl of an amino acid residue at position n with the alpha amino of a glycine residue at position n+2 to form a 5-imidazolinone ring." [PubMed:18688235]
is_a: MOD:00691 ! 5-imidazolinone ring crosslinked residues

[Term]
id: MOD:01883
name: 5-imidazolinone ring crosslinked residues (Cys)
def: "A protein modification that crosslinks two residues by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 5-imidazolinone ring." [PubMed:18688235]
is_a: MOD:00691 ! 5-imidazolinone ring crosslinked residues

[Term]
id: MOD:01884
name: 4-aminobutylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a 4-aminobutyl group, usually derived from spermidine." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "X"
xref: TermSpec: "none"
is_a: MOD:00001 ! alkylated residue

[Term]
id: MOD:01885
name: biotinylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a biotinyl group." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl" EXACT PSI-MOD-alternate []
synonym: "Biotinylation" EXACT PSI-MOD-alternate []
synonym: "BtnRes" EXACT PSI-MOD-label []
xref: DiffAvg: "226.29"
xref: DiffFormula: "C 10 H 14 N 2 O 2 S 1"
xref: DiffMono: "226.077599"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue

[Term]
id: MOD:01886
name: thiolated residue
def: "A protein modification that effectively replaces a hydrogen atom with an sulfanyl or substituted sulfanyl group." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "X"
xref: TermSpec: "none"
is_a: MOD:00860 ! sulfur containing modified residue

[Term]
id: MOD:01887
name: Uniblue A derivatized lysine
def: "A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A lysine adduct." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate []
synonym: "1-amino-9,10-dioxo-4-{[3-(vinylsulfonyl)phenyl]amino}-9,10-dihydroanthracene-2-sulfonate" EXACT PSI-MOD-alternate []
synonym: "N6UniblueALys" EXACT PSI-MOD-label []
synonym: "Uniblue A" EXACT PSI-MOD-alternate []
xref: DiffAvg: "484.50"
xref: DiffFormula: "C 22 H 16 N 2 O 7 S 2"
xref: DiffMono: "484.039893"
xref: Formula: "C 28 H 28 N 4 O 8 S 2"
xref: MassAvg: "612.67"
xref: MassMono: "612.134856"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01659 ! Uniblue A derivatized residue

[Term]
id: MOD:01888
name: didehydrogenated residue
def: "A protein modification that effectively removes two neutral hydrogen atoms (proton and electron) from a residue." [Unimod:401]
subset: PSI-MOD-slim
synonym: "2dHRes" EXACT PSI-MOD-label []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0"
xref: DiffMono: "-2.015650"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
xref: Unimod: "Unimod:401"
is_a: MOD:00683 ! dehydrogenated residue

[Term]
id: MOD:01889
name: S-(2-succinyl)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(2-succinyl)-L-cysteine, by addition of either fumaric acid or maleic acid." [PubMed:16624247, PubMed:18448829, PubMed:20677745, RESID:AA0561, Unimod:957]
synonym: "(2R)-2-amino-3-([(1R)-1,2-dicarboxyethyl]sulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "(2R)-2-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanedioic acid" EXACT RESID-alternate []
synonym: "2-((2-amino-2-carboxyethyl)thio)butanedioic acid" EXACT RESID-alternate []
synonym: "2-amino-3-(1,2-dicarboxyethylthio)propanoic acid" EXACT RESID-alternate []
synonym: "S-(1,2-dicarboxyethyl)cysteine" EXACT RESID-alternate []
synonym: "S-(2-succinyl)-L-cysteine" EXACT RESID-name []
synonym: "S-(2-succinyl)cysteine" EXACT RESID-alternate []
synonym: "S-[(2R)-2-succinyl]-L-cysteine" EXACT RESID-alternate []
synonym: "MOD_RES S-(2-succinyl)cysteine" EXACT UniProt-feature []
xref: DiffAvg: "116.07"
xref: DiffFormula: "C 4 H 4 N 0 O 4 S 0"
xref: DiffMono: "116.010959"
xref: Formula: "C 7 H 9 N 1 O 5 S 1"
xref: MassAvg: "219.21"
xref: MassMono: "219.020143"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:957"
xref: uniprot.ptm:PTM-0674
is_a: MOD:00001 ! alkylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01890
name: N-[(L-histidin-1'-yl)methyl]-L-methionine (fMet)
def: "A protein modification that effectively crosslinks an N-formyl-L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine." [PubMed:19622680, RESID:AA0566#FMET]
comment: Cross-link 2.
synonym: "(2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "N-[(L-histidin-1'-yl)methyl]-L-methionine" EXACT RESID-name []
xref: DiffAvg: "-16.00"
xref: DiffFormula: "C 0 H 0 N 0 O -1 S 0"
xref: DiffMono: "-15.994915"
xref: Formula: "C 12 H 17 N 4 O 2 S 1"
xref: MassAvg: "281.35"
xref: MassMono: "281.107222"
xref: Origin: "H, MOD:00030"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
is_a: MOD:02048 ! crosslinked L-histidine residue
is_a: MOD:02062 ! crosslinked N-formyl-L-methionine residue

[Term]
id: MOD:01891
name: N-[(L-histidin-1'-yl)methyl]-L-methionine (Met)
def: "A protein modification that effectively crosslinks an L-methionine residue and an L-histidine residue to form N-[(L-histidin-1'-yl)methyl]-L-methionine." [PubMed:19622680, RESID:AA0566#MET]
comment: Cross-link 2.
synonym: "(2S)-2-([(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-1-yl)methyl]amino)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "N-[(L-histidin-1'-yl)methyl]-L-methionine" EXACT RESID-name []
xref: DiffAvg: "12.01"
xref: DiffFormula: "C 1 H 0 N 0 O 0 S 0"
xref: DiffMono: "12.000000"
xref: Formula: "C 12 H 17 N 4 O 2 S 1"
xref: MassAvg: "281.35"
xref: MassMono: "281.107222"
xref: Origin: "H, M"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
is_a: MOD:02048 ! crosslinked L-histidine residue
is_a: MOD:02052 ! crosslinked L-methionine residue

[Term]
id: MOD:01892
name: N6-crotonyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-crotonyl-L-lysine." [PubMed:21925322, RESID:AA0567]
synonym: "(2S)-2-amino-6-[(2E)-but-2-enamido]hexanoic acid" EXACT RESID-alternate []
synonym: "(2S)-2-amino-6-[(2E)-but-2-enoylamino]hexanoic acid" EXACT RESID-systematic []
synonym: "(2S)-2-azanyl-6-[(2E)-but-2-enoylazanyl]hexanoic acid" EXACT RESID-alternate []
synonym: "MOD_RES N6-crotonyl-L-lysine" EXACT UniProt-feature []
synonym: "N(epsilon)-crotonyllysine" EXACT RESID-alternate []
synonym: "N6-(E)-crotonyllysine" EXACT RESID-alternate []
synonym: "N6-[(2E)-2-butenoyl]-L-lysine" EXACT RESID-alternate []
synonym: "N6-crotonyl-L-lysine" EXACT RESID-name []
synonym: "N6-crotonyllysine" EXACT RESID-alternate []
synonym: "N6-trans-crotonyllysine" EXACT RESID-alternate []
xref: DiffAvg: "68.07"
xref: DiffFormula: "C 4 H 4 N 0 O 1"
xref: DiffMono: "68.026215"
xref: Formula: "C 10 H 16 N 2 O 2"
xref: MassAvg: "196.25"
xref: MassMono: "196.121178"
xref: Origin: "K"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0475
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01893
name: N6-malonyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-malonyl-L-lysine." [PubMed:21908771, PubMed:8349414, RESID:AA0568]
synonym: "(2S)-2-amino-6-[(carboxyacetyl)amino]hexanoic acid" EXACT RESID-systematic []
synonym: "2-azanyl-6-[(carboxyacetyl)azanyl]hexanoic acid" EXACT RESID-alternate []
synonym: "malonyllysine" EXACT RESID-alternate []
synonym: "MOD_RES N6-malonyllysine" EXACT UniProt-feature []
synonym: "N(epsilon)-(malonyl)lysine" EXACT RESID-alternate []
synonym: "N6-(carboxyacetyl)lysine" EXACT RESID-alternate []
synonym: "N6-malonyl-L-lysine" EXACT RESID-name []
synonym: "N6-malonyllysine" EXACT RESID-alternate []
xref: DiffAvg: "86.05"
xref: DiffFormula: "C 3 H 2 N 0 O 3"
xref: DiffMono: "86.000394"
xref: Formula: "C 9 H 14 N 2 O 4"
xref: MassAvg: "214.22"
xref: MassMono: "214.095357"
xref: Origin: "K"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0467
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01894
name: propanoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, Unimod:58]
synonym: "Propionate labeling reagent light form (N-term & K)" RELATED Unimod-description []
synonym: "Propionyl" RELATED PSI-MS-label []
xref: DiffAvg: "56.06"
xref: DiffFormula: "C 3 H 4 O 1"
xref: DiffMono: "56.026215"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:58"
is_a: MOD:00649 ! acylated residue

[Term]
id: MOD:01895
name: alpha-amino 3x(12)C-labeled propanoylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(12)C-labeled propanoyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, Unimod:58#N-term]
synonym: "Propionate labeling reagent light form (N-term & K)" RELATED Unimod-description []
synonym: "Propionyl" RELATED PSI-MS-label []
xref: DiffAvg: "56.03"
xref: DiffFormula: "(12)C 3 H 4 O 1"
xref: DiffMono: "56.026215"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:58"
relationship: derives_from MOD:00451 ! alpha-amino propanoylated residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:01896
name: trifluoroacetic acid adduct
def: "A protein modification produced by trifluoroacetic acid forming an adduct, either a salt or a hydrogen bonded carboxylic acid dimer, with an amino acid residue." [PubMed:18688235]
comment: Trifluoroacetic acid has been observed to form adducts in both negative and positive mode analysis (Mark Collins, private communication) [JSG].
synonym: "TFA" EXACT DeltaMass-label []
xref: DiffAvg: "114.02"
xref: DiffFormula: "C 2 F 3 H 1 O 2"
xref: DiffMono: "113.992864"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00498 ! fluorinated residue
is_a: MOD:00848 ! reagent derivatized residue

[Term]
id: MOD:01897
name: 5-hydroxy-3-methyl-L-proline (Ile)
def: "A protein modification that effectively converts an L-isoleucine residue to 5-hydroxy-3-methyl-L-proline." [PubMed:21788474, PubMed:7592021, PubMed:8557573, RESID:AA0473]
synonym: "(2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "5-hydroxy-3-methyl-L-proline" EXACT RESID-name []
synonym: "5-hydroxy-3-methylproline" EXACT RESID-alternate []
synonym: "5Hy3MePro(Ile)" EXACT PSI-MOD-label []
synonym: "beta-methyl-delta-hydroxyproline" EXACT RESID-alternate []
synonym: "MOD_RES 5-hydroxy-3-methylproline (Ile)" EXACT UniProt-feature []
xref: DiffAvg: "13.98"
xref: DiffFormula: "C 0 H -2 N 0 O 1"
xref: DiffMono: "13.979265"
xref: Formula: "C 6 H 9 N 1 O 2"
xref: MassAvg: "127.14"
xref: MassMono: "127.063329"
xref: Origin: "I"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0466
is_a: MOD:00601 ! cyclized residue
is_a: MOD:00679 ! carbon oxygenated residue
is_a: MOD:00910 ! modified L-isoleucine residue
is_a: MOD:01905 ! 5-hydroxy-3-methyl-L-proline

[Term]
id: MOD:01898
name: N2,N2-dimethyl-L-arginine
def: "modification from RESID" [PubMed:21568297, PubMed:21950656, RESID:AA0569]
synonym: "(2S)-5-[(diaminomethylidene)amino]-2-(dimethylamino)pentanoic acid" EXACT RESID-systematic []
synonym: "(2S)-5-carbamimidamido-2-(dimethylamino)pentanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "MOD_RES N2,N2-dimethylarginine" EXACT UniProt-feature []
synonym: "N(alpha),N(alpha)-dimethylarginine" EXACT RESID-alternate []
synonym: "N2,N2-dimethyl-L-arginine" EXACT RESID-name []
synonym: "N2,N2-dimethylarginine" EXACT RESID-alternate []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4 N 0 O 0"
xref: DiffMono: "28.031300"
xref: Formula: "C 8 H 17 N 4 O 1"
xref: MassAvg: "185.25"
xref: MassMono: "185.140236"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0459
is_a: MOD:00783 ! dimethylated L-arginine

[Term]
id: MOD:01899
name: L-arginine thiazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-arginine residue and an L-cysteine residue to form arginine thiazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0570]
comment: Cross-link 2.
synonym: "2-[(1S)-1-amino-4-([diaminomethylidene]amino)butyl]-1,3-thiazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "CROSSLNK Thiazole-4-carboxylic acid (Arg-Cys)" EXACT UniProt-feature []
synonym: "L-arginine thiazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 9 H 13 N 5 O 1 S 1"
xref: MassAvg: "239.30"
xref: MassMono: "239.084081"
xref: Origin: "C, R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0460
is_a: MOD:02041 ! crosslinked L-arginine residue
is_a: MOD:01420 ! thiazole/thiazoline ring crosslinked residues
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01900
name: L-cysteine 5-methyloxazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-cysteine 5-methyloxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0571]
comment: Cross-link 2.
synonym: "2-[(1R)-1-amino-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[(1R)-1-azanyl-2-sulfanylethyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK 5-methyloxazole-4-carboxylic acid (Cys-Thr)" EXACT UniProt-feature []
synonym: "L-cysteine 5-methyloxazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1 S 0"
xref: DiffMono: "-20.026215"
xref: Formula: "C 7 H 8 N 2 O 2 S 1"
xref: MassAvg: "184.21"
xref: MassMono: "184.030649"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0461
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr)
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01901
name: L-threonine 5-methyloxazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks two L-threonine residues to form L-threonine 5-methyloxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0572]
comment: Cross-link 2.
synonym: "2-[(1S,2R)-1-amino-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[(1S,2R)-1-azanyl-2-hydroxypropyl]-5-methyl-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK 5-methyloxazole-4-carboxylic acid (Thr-Thr)" EXACT UniProt-feature []
synonym: "L-threonine 5-methyloxazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1"
xref: DiffMono: "-20.026215"
xref: Formula: "C 8 H 10 N 2 O 3"
xref: MassAvg: "182.18"
xref: MassMono: "182.069142"
xref: Origin: "T, T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0462
is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr)
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01902
name: L-isoleucine oxazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-isoleucine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0573]
comment: Cross-link 2.
synonym: "2-[(1S,2S)-1-amino-2-methylbutyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[(1S,2S)-1-azanyl-2-methylbutyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Oxazole-4-carboxylic acid (Ile-Ser)" EXACT UniProt-feature []
synonym: "L-isoleucine oxazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1"
xref: DiffMono: "-20.026215"
xref: Formula: "C 9 H 12 N 2 O 2"
xref: MassAvg: "180.21"
xref: MassMono: "180.089878"
xref: Origin: "I, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0463
is_a: MOD:02049 ! crosslinked L-isoleucine residue
is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser)
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01903
name: L-serine oxazole-4-carboxylic acid
def: "A protein modification that effectively crosslinks two L-serine residues to form serine oxazole-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0574]
comment: Cross-link 2.
synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[(1S)-1-azanyl-2-hydroxyethyl]-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK Oxazole-4-carboxylic acid (Ser-Ser)" EXACT UniProt-feature []
synonym: "L-serine oxazole-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1"
xref: DiffMono: "-20.026215"
xref: Formula: "C 6 H 6 N 2 O 3"
xref: MassAvg: "154.13"
xref: MassMono: "154.037842"
xref: Origin: "S, S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0464
is_a: MOD:01421 ! oxazole/oxazoline ring crosslinked residues (Ser)
is_a: MOD:02082 ! didehydrogenated and dehydrated residue

[Term]
id: MOD:01904
name: L-serine 5-methyloxazoline-4-carboxylic acid
def: "A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazoline-4-carboxylic acid." [PubMed:21568297, PubMed:21950656, RESID:AA0575]
comment: Cross-link 2.
synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-1,3-oxazoline-4-carboxylic acid" EXACT RESID-alternate []
synonym: "2-[(1S)-1-amino-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-systematic []
synonym: "2-[(1S)-1-azanyl-2-hydroxyethyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid" EXACT RESID-alternate []
synonym: "CROSSLNK 5-methyloxazoline-4-carboxylic acid (Ser-Thr)" EXACT UniProt-feature []
synonym: "L-serine 5-methyloxazoline-4-carboxylic acid" EXACT RESID-name []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 7 H 10 N 2 O 3"
xref: MassAvg: "170.17"
xref: MassMono: "170.069142"
xref: Origin: "S, T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0465
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01422 ! oxazole/oxazoline ring crosslinked residues (Thr)
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01905
name: 5-hydroxy-3-methyl-L-proline
def: "A protein modification that effectively converts a source amino acid residue to 5-hydroxy-3-methyl-L-proline." [PubMed:7592021, PubMed:8557573, RESID:AA0473]
synonym: "(2S,3S,5Xi)-5-hydroxy-3-methylpyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "5-hydroxy-3-methyl-L-proline" EXACT RESID-name []
synonym: "5-hydroxy-3-methylproline" EXACT RESID-alternate []
synonym: "5Hy3MePro" EXACT PSI-MOD-label []
synonym: "beta-methyl-delta-hydroxyproline" EXACT RESID-alternate []
synonym: "MOD_RES 5-hydroxy-3-methylproline (Ile)" EXACT UniProt-feature []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 6 H 9 N 1 O 2"
xref: MassAvg: "127.14"
xref: MassMono: "127.063329"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
relationship: has_functional_parent MOD:01024 ! monohydroxylated proline

[Term]
id: MOD:01906
name: dehydromethionine
def: "A protein modification that effectively converts an L-methionine residue to dehydromethionine." [PubMed:18688235, PubMed:19775156]
synonym: "(3S)-3-carboxy-1-methylisothiazolidin-1-ium" EXACT PSI-MOD-alternate []
synonym: "L-dehydromethionine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-1.01"
xref: DiffFormula: "C 0 H -1 N 0 O 0 S 0"
xref: DiffMono: "-1.008374"
xref: FormalCharge: "1+"
xref: Formula: "C 5 H 9 N 1 O 1 S 1"
xref: MassAvg: "131.19"
xref: MassMono: "131.039936"
xref: Origin: "M"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00601 ! cyclized residue
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:01907
name: dehydromethionine (from L-methioninium)
def: "A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to dehydromethionine." [PubMed:18688235, PubMed:19775156]
comment: This process accounts only for cyclizaation and not protonation. The alternative process (MOD:01906) accounts for both protonation and cyclization.
synonym: "(3S)-3-carboxy-1-methylisothiazolidin-1-ium" EXACT PSI-MOD-alternate []
synonym: "L-dehydromethionine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.016199"
xref: FormalCharge: "1+"
xref: Formula: "C 5 H 9 N 1 O 1 S 1"
xref: MassAvg: "131.19"
xref: MassMono: "131.039936"
xref: Origin: "MOD:001464"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:00601 ! cyclized residue
is_a: MOD:00913 ! modified L-methionine residue
relationship: derives_from MOD:01464 ! protonated L-methionine (L-methioninium) residue

[Term]
id: MOD:01908
name: 4-sulfophenyl isothiocyanate alpha-amino derivatized residue
def: "A protein modification that effectively converts a residue to the 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue." [PubMed:14689565, PubMed:14745769, PubMed:15549660, PubMed:16526082, Unimod:261#N-term]
synonym: "4-sulfophenyl isothiocyanate" RELATED Unimod-description []
synonym: "alpha-amino-[(4-sulfophenyl)carbamothioyl] residue" EXACT PSI-MOD-alternate []
synonym: "SPITC" RELATED PSI-MS-label []
xref: DiffAvg: "215.24"
xref: DiffFormula: "C 7 H 5 N 1 O 3 S 2"
xref: DiffMono: "214.971085"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:261"
is_a: MOD:00584 ! 4-sulfophenyl isothiocyanate derivatized residue

[Term]
id: MOD:01909
name: 6x(13)C labeled 4-sulfophenyl isothiocyanate alpha-amino derivatized residue
def: "A protein modification that effectively converts a residue to the 6x(13)C labeled 4-sulfophenyl isothiocyanate adduct, alpha-amino-[(4-sulfophenyl)carbamothioyl] residue." [PubMed:11467524, PubMed:16526082, Unimod:464#N-term]
synonym: "4-sulfophenyl isothiocyanate (Heavy C13)" RELATED Unimod-description []
synonym: "SPITC:13C(6)" RELATED PSI-MS-label []
xref: DiffAvg: "220.99"
xref: DiffFormula: "(12)C 1 (13)C 6 H 5 N 1 O 3 S 2"
xref: DiffMono: "220.991214"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:464"
is_a: MOD:00880 ! 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue

[Term]
id: MOD:01910
name: monofluorinated residue
def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one fluorine atom." [Unimod:127]
synonym: "F1Res" EXACT PSI-MOD-label []
xref: DiffAvg: "17.99"
xref: DiffFormula: "C 0 F 1 H -1 N 0 O 0"
xref: DiffMono: "17.990578"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:127"
is_a: MOD:00498 ! fluorinated residue

[Term]
id: MOD:01911
name: monochlorinated residue
def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one chlorine atom." [Unimod:936]
synonym: "Cl1Res" EXACT PSI-MOD-label []
xref: DiffAvg: "34.44"
xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0"
xref: DiffMono: "33.961028"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:936"
is_a: MOD:00753 ! chlorinated residue

[Term]
id: MOD:01912
name: monobrominated residue
def: "A protein modification that effectively substitutes one hydrogen atom of a residue with one bromine atom." [Unimod:340]
synonym: "Br1Res" EXACT PSI-MOD-label []
xref: DiffAvg: "78.90"
xref: DiffFormula: "Br 1 C 0 H -1 N 0 O 0"
xref: DiffMono: "77.910512"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
xref: Unimod: "Unimod:340"
is_a: MOD:00754 ! brominated residue

[Term]
id: MOD:01913
name: monochlorinated L-tryptophan
def: "A protein modification that effectively substitutes one hydrogen atom of an L-tryptophan residue with one chlorine atom." [PubMed:18688235]
synonym: "Cl1Trp" EXACT PSI-MOD-label []
xref: DiffAvg: "34.44"
xref: DiffFormula: "C 0 Cl 1 H -1 N 0 O 0"
xref: DiffMono: "33.961028"
xref: Formula: "C 11 Cl 1 H 9 N 2 O 1"
xref: MassAvg: "220.66"
xref: MassMono: "220.040341"
xref: Origin: "W"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01068 ! halogenated tryptophan
is_a: MOD:01911 ! monochlorinated residue

[Term]
id: MOD:01914
name: O5-galactosyl-L-hydroxylysine
def: "A protein modification that effectively converts a 5-hydroxy-L-lysine residue to O5-galactosyl-L-hydroxylysine." [PMID:743239, PubMed:17516569, Unimod:907]
comment: Secondary to RESID:AA0028. This intermediate is rarely observed [JSG].
subset: PSI-MOD-slim
synonym: "Galactosyl hydroxylysine" RELATED Unimod-description []
synonym: "OGal5HyLys" EXACT PSI-MOD-label []
synonym: "CARBOHYD O-linked (Gal) hydroxylysine" EXACT UniProt-feature []
xref: DiffAvg: "162.14"
xref: DiffFormula: "C 6 H 10 O 5"
xref: DiffMono: "162.052823"
xref: Formula: "C 16 H 22 N 2 O 7"
xref: MassAvg: "354.36"
xref: MassMono: "354.142701"
xref: Origin: "MOD:00037"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:907"
xref: uniprot.ptm:PTM-0556
is_a: MOD:00476 ! monogalactosylated residue
is_a: MOD:00396 ! O-glycosylated residue

[Term]
id: MOD:01915
name: N-formyl-L-alanine
def: "A protein modification that effectively converts an L-alanine residue to N-formyl-L-alanine." [PubMed:9334739, RESID:AA0576]
synonym: "(2S)-2-(formylamino)propanoic acid" EXACT RESID-systematic []
synonym: "2-formamidopropanoic acid" EXACT RESID-alternate []
synonym: "2-formamidopropionic acid" EXACT RESID-alternate []
synonym: "N-formyl-L-alanine" EXACT RESID-name []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 H 0 N 0 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "C 4 H 6 N 1 O 2"
xref: MassAvg: "100.10"
xref: MassMono: "100.039853"
xref: Origin: "A"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
is_a: MOD:00409 ! N-formylated residue
is_a: MOD:00901 ! modified L-alanine residue

[Term]
id: MOD:01916
name: O4'-(N-acetylamino)galactosyl-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to O4'-(N-acetylamino)galactosyl-L-tyrosine." [PubMed:21712440, PubMed:21983924, RESID:AA0577]
synonym: "(2S)-2-amino-3-(D-2-acetamido-2-deoxygalactopyranosyloxy)phenylpropanoic acid" EXACT RESID-systematic []
synonym: "CARBOHYD O-linked (GalNAc) tyrosine" EXACT UniProt-feature []
synonym: "mucin type O-glycosyltyrosine" EXACT RESID-alternate []
synonym: "O4'-(N-acetylamino)galactosyl-L-tyrosine" EXACT RESID-name []
synonym: "O4'-(N-acetylgalactosaminyl)tyrosine" EXACT RESID-alternate []
synonym: "O4'-glycosyl-L-tyrosine" EXACT RESID-alternate []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "C 17 H 22 N 2 O 7"
xref: MassAvg: "366.37"
xref: MassMono: "366.142701"
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0570
is_a: MOD:00563 ! mono-N-acetylaminogalactosylated residue
is_a: MOD:01927 ! O-glycosyl-L-tyrosine

[Term]
id: MOD:01917
name: N6-(L-isoaspartyl)-L-lysine (Asp)
def: "A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of water." [ChEBI:21862, PubMed:11000116, PubMed:15044436, PubMed:18063798, PubMed:6503713, RESID:AA0294#ASP]
comment: Cross-link 2.
synonym: "(2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "beta-(N6-lysyl)aspartyl acid" EXACT RESID-alternate []
synonym: "CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn)" EXACT UniProt-feature []
synonym: "isoaspartyl N6-lysine" EXACT RESID-alternate []
synonym: "N(epsilon)-(beta-aspartyl)lysine" EXACT RESID-alternate []
synonym: "N6-(L-isoaspartyl)-L-lysine" EXACT RESID-name []
synonym: "XLNK-4Asp-N6Lys(Asp)" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 10 H 15 N 3 O 3"
xref: MassAvg: "225.25"
xref: MassMono: "225.111341"
xref: Origin: "D, K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0486
is_a: MOD:02043 ! crosslinked L-aspartic acid residue
is_a: MOD:01929 ! N6-(L-isoaspartyl)-L-lysine
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01918
name: (2S,5S)-5-hydroxylysine
def: "A protein modification that effectively converts an L-lysine residue to (2S,5S)-5-hydroxylysine." [PubMed:19574390, PubMed:22238144, RESID:AA0578]
subset: PSI-MOD-slim
synonym: "(2S,5S)-2,6-diamino-5-hydroxyhexanoic acid" EXACT RESID-systematic []
synonym: "(2S,5S)-5-hydroxylysine" EXACT RESID-name []
synonym: "2,6-bisazanyl-5-hydroxyhexanoic acid" EXACT RESID-alternate []
synonym: "2,6-diamino-2,3,4,6-tetradeoxyhexonic acid" EXACT RESID-alternate []
synonym: "alpha,epsilon-diamino-delta-hydroxycaproic acid" EXACT RESID-alternate []
synonym: "L-allo-delta-hydroxylysine" EXACT RESID-alternate []
synonym: "L-threo-delta-hydroxylysine" EXACT RESID-alternate []
synonym: "MOD_RES (5S)-5-hydroxylysine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 12 N 2 O 2"
xref: MassAvg: "144.17"
xref: MassMono: "144.089878"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0472
is_a: MOD:00037 ! 5-hydroxy-L-lysine

[Term]
id: MOD:01919
name: (2S,3S)-3-hydroxyaspartic acid
def: "A protein modification that effectively converts an L-aspartic acid residue to (2S,3S)-3-hydroxyaspartic acid." [ChEBI:10696, PubMed:21177872, RESID:AA0579, ChEBI:138111]
subset: PSI-MOD-slim
synonym: "(2S,3S)-2-amino-3-hydroxybutanedioic acid" EXACT RESID-systematic []
synonym: "(2S,3S)-3-hydroxyaspartic acid" EXACT RESID-name []
synonym: "(3S)-3-hydroxy-L-aspartic acid" EXACT RESID-alternate []
synonym: "2-amino-3-hydroxysuccinic acid" EXACT RESID-alternate []
synonym: "2-azanyl-3-hydroxybutanedioic acid" EXACT RESID-alternate []
synonym: "3-hydroxyaspartic acid" EXACT RESID-alternate []
synonym: "L-threo-3-hydroxyaspartic acid" EXACT RESID-alternate []
synonym: "L-threo-beta-hydroxyaspartic acid" EXACT RESID-alternate []
synonym: "MOD_RES (3S)-3-hydroxyaspartate" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 4 H 5 N 1 O 4"
xref: MassAvg: "131.09"
xref: MassMono: "131.021858"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0473
is_a: MOD:01926 ! 3-hydroxy-L-aspartic acid

[Term]
id: MOD:01920
name: 3-hydroxy-L-histidine
def: "A protein modification that effectively converts an L-histidine residue to 3-hydroxy-L-histidine." [PubMed:21251231, RESID:AA0580, ChEBI:138021]
synonym: "(2S)-2-amino-3-hydroxy-3-(1H-imidazol-4-yl)propanoic acid" EXACT RESID-systematic []
synonym: "3-hydroxy-L-histidine" EXACT RESID-name []
synonym: "MOD_RES (3S)-3-hydroxyhistidine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 7 N 3 O 2"
xref: MassAvg: "153.14"
xref: MassMono: "153.053826"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0477
is_a: MOD:00909 ! modified L-histidine residue
is_a: MOD:00677 ! hydroxylated residue

[Term]
id: MOD:01921
name: D-aspartic acid (Asp)
def: "A protein modification that effectively converts an L-aspartic acid residue to D-aspartic acid." [ChEBI:48094, PubMed:9384562, RESID:AA0190#ASP]
synonym: "(2R)-2-aminobutanedioic acid" EXACT RESID-systematic []
synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate []
synonym: "aminosuccinic acid" EXACT RESID-alternate []
synonym: "D-aspartic acid" EXACT RESID-name []
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Formula: "C 4 H 5 N 1 O 3"
xref: MassAvg: "115.09"
xref: MassMono: "115.026943"
xref: Origin: "D"
xref: Source: "artifactual"
xref: TermSpec: "none"
is_a: MOD:00904 ! modified L-aspartic acid residue
is_a: MOD:01942 ! D-aspartic acid

[Term]
id: MOD:01922
name: 3-methoxydehydroalanine
def: "A protein modification that effectively converts an L-serine residue to 3-methoxydehydroalanine." [PubMed:19745839, RESID:AA0582]
synonym: "2-amino-3-methoxyprop-2-enoic acid" EXACT RESID-systematic []
synonym: "3-methoxydehydroalanine" EXACT RESID-name []
synonym: "3-methoxydidehydroalanine" EXACT RESID-alternate []
xref: DiffAvg: "12.01"
xref: DiffFormula: "C 1 H 0 N 0 O 0"
xref: DiffMono: "12.000000"
xref: Formula: "C 4 H 5 N 1 O 2"
xref: MassAvg: "99.09"
xref: MassMono: "99.032028"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00916 ! modified L-serine residue
relationship: has_functional_parent MOD:00189 ! dehydroalanine (Ser)

[Term]
id: MOD:01923
name: N6-(L-aspartyl)-L-lysine
def: "A protein modification that effectively crosslinks an L-aspartic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-aspartyl)-L-lysine and the release of water." [PubMed:15044436, RESID:AA0583]
comment: Cross-link 2.
synonym: "(2S)-2-amino-6-([(2S)-2-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "alpha-(N6-lysyl)aspartyl acid" EXACT RESID-alternate []
synonym: "aspartyl N6-lysine" EXACT RESID-alternate []
synonym: "N(epsilon)-(alpha-aspartyl)lysine" EXACT RESID-alternate []
synonym: "N6-(L-aspartyl)-L-lysine" EXACT RESID-name []
synonym: "XLNK-4Asp-N6Lys(Asp)" EXACT PSI-MOD-label []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 10 H 16 N 3 O 4"
xref: MassAvg: "242.26"
xref: MassMono: "242.114081"
xref: Origin: "D, K"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00688 ! isopeptide crosslinked residues
is_a: MOD:02043 ! crosslinked L-aspartic acid residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01924
name: S-octanoyl-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-octanoyl-L-cysteine." [PubMed:12591875, PubMed:16342964, RESID:AA0584]
synonym: "(2S)-2-amino-3-(octanoylsulfanyl)propanoic acid" EXACT RESID-systematic []
synonym: "2-amino-3-(octanoylthio)propanoic acid" EXACT RESID-alternate []
synonym: "ACT_SITE Acyl-thioester intermediate" EXACT UniProt-feature []
synonym: "cysteine octanoate thioester" EXACT RESID-alternate []
synonym: "S-octanoyl-L-cysteine" EXACT RESID-name []
xref: DiffAvg: "126.20"
xref: DiffFormula: "C 8 H 14 N 0 O 1 S 0"
xref: DiffMono: "126.104465"
xref: Formula: "C 11 H 19 N 1 O 2 S 1"
xref: MassAvg: "229.34"
xref: MassMono: "229.113650"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00666 ! octanoylated residue
is_a: MOD:00672 ! S-acylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01925
name: (2S,5R)-5-hydroxylysine
def: "A protein modification that effectively converts an L-lysine residue to (2S,5R)-5-hydroxylysine." [ChEBI:18040, PubMed:13375629, PubMed:15504407, PubMed:16101297, PubMed:2857489, RESID:AA0028]
subset: PSI-MOD-slim
synonym: "(2S,5R)-2,6-diamino-5-hydroxyhexanoic acid" EXACT RESID-systematic []
synonym: "(2S,5R)-5-hydroxylysine" EXACT RESID-name []
synonym: "2,6-bisazanyl-5-hydroxyhexanoic acid" EXACT RESID-alternate []
synonym: "2,6-diamino-2,3,4,6-tetradeoxyhexonic acid" EXACT RESID-alternate []
synonym: "5-hydroxylated L-lysine" EXACT PSI-MOD-alternate []
synonym: "5HyLys" EXACT PSI-MOD-label []
synonym: "alpha,epsilon-diamino-delta-hydroxycaproic acid" EXACT RESID-alternate []
synonym: "L-erythro-delta-hydroxylysine" EXACT RESID-alternate []
synonym: "MOD_RES (2S,5R)-5-hydroxylysine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 12 N 2 O 2"
xref: MassAvg: "144.17"
xref: MassMono: "144.089878"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0471
is_a: MOD:00037 ! 5-hydroxy-L-lysine

[Term]
id: MOD:01926
name: 3-hydroxy-L-aspartic acid
def: "A protein modification that effectively converts an L-aspartic acid residue to one of the diastereomeric 3-hydroxy-L-aspartic acid residues." [OMSSA:59, Unimod:35#D]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-hydroxybutanedioic acid" EXACT PSI-MOD-alternate []
synonym: "(2S)-3-hydroxyaspartic acid" EXACT PSI-MOD-alternate []
synonym: "3HyAsp" EXACT PSI-MOD-label []
synonym: "erythro-beta-hydroxylated L-aspartic acid" EXACT PSI-MOD-alternate []
synonym: "hydroxylationd" EXACT OMSSA-label []
synonym: "monohydroxylated aspartic acid" EXACT PSI-MOD-alternate []
synonym: "Oxidation" RELATED PSI-MS-label []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 4 H 5 N 1 O 4"
xref: MassAvg: "131.09"
xref: MassMono: "131.021858"
xref: Origin: "D"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:35"
is_a: MOD:00425 ! monohydroxylated residue
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:01927
name: O-glycosyl-L-tyrosine
def: "A protein modification that effectively converts an L-tyrosine residue to O4'-glycosyltyrosine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "OGlycoTyr" EXACT PSI-MOD-label []
xref: Origin: "Y"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00396 ! O-glycosylated residue
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:01928
name: N-(L-isoaspartyl)-glycine
def: "A protein modification that effectively crosslinks either an L-asparagine residue or an L-aspartic acid residue with a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine." [ChEBI:21479, PubMed:1826288, RESID:AA0126]
comment: Cross-link 2.
synonym: "(2S)-2-amino-4-(carboxymethyl)amino-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "2-amino-N4-(carboxymethyl)-butanediamic acid" EXACT RESID-alternate []
synonym: "isoaspartyl glycine" EXACT RESID-alternate []
synonym: "N-(L-isoaspartyl)-glycine" EXACT RESID-name []
synonym: "N-beta-aspartylglycine" EXACT RESID-alternate []
synonym: "N4-(carboxymethyl)-asparagine" EXACT RESID-alternate []
synonym: "XLNK-4Asp-NGly" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 6 H 7 N 2 O 3"
xref: MassAvg: "155.13"
xref: MassMono: "155.045667"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00688 ! isopeptide crosslinked residues
is_a: MOD:02047 ! crosslinked glycine residue

[Term]
id: MOD:01929
name: N6-(L-isoaspartyl)-L-lysine
def: "A protein modification that effectively crosslinks an either an L-asparagine residue or an L-aspartic acid residue with an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine." [ChEBI:21862, DeltaMass:0, PubMed:11000116, PubMed:6503713, RESID:AA0294]
comment: Cross-link 2.
synonym: "(2S)-2-amino-6-([(3S)-3-amino-3-carboxypropanoyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "beta-(N6-lysyl)aspartyl acid" EXACT RESID-alternate []
synonym: "CROSSLNK Isoaspartyl lysine isopeptide (Lys-Asn)" EXACT UniProt-feature []
synonym: "isoaspartyl N6-lysine" EXACT RESID-alternate []
synonym: "N(epsilon)-(beta-aspartyl)lysine" EXACT RESID-alternate []
synonym: "N-(beta-Aspartyl)-Lysine (Crosslink)" EXACT DeltaMass-label []
synonym: "N6-(L-isoaspartyl)-L-lysine" EXACT RESID-name []
synonym: "XLNK-4Asp-N6Lys" EXACT PSI-MOD-label []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 10 H 15 N 3 O 3"
xref: MassAvg: "225.25"
xref: MassMono: "225.111341"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00688 ! isopeptide crosslinked residues
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01930
name: D-aspartic acid (Asn)
def: "A protein modification that effectively converts an L-asparagine residue to D-aspartic acid." [ChEBI:48094, PubMed:9384562, RESID:AA0190#ASN]
synonym: "(2R)-2-aminobutanedioic acid" EXACT RESID-systematic []
synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate []
synonym: "aminosuccinic acid" EXACT RESID-alternate []
synonym: "D-aspartic acid" EXACT RESID-name []
xref: DiffAvg: "0.98"
xref: DiffFormula: "C 0 H -1 N -1 O 1"
xref: DiffMono: "0.984016"
xref: Formula: "C 4 H 5 N 1 O 3"
xref: MassAvg: "115.09"
xref: MassMono: "115.026943"
xref: Origin: "N"
xref: Source: "artifactual"
xref: TermSpec: "none"
is_a: MOD:00903 ! modified L-asparagine residue
is_a: MOD:01942 ! D-aspartic acid

[Term]
id: MOD:01931
name: N6-phospho-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-phospho-L-lysine." [PubMed:20144148, RESID:AA0585]
synonym: "(2S)-2-amino-6-(phosphonoamino)hexanoic acid" EXACT RESID-systematic []
synonym: "(2S)-2-azanyl-6-(phosphonoamino)hexanoic acid" EXACT RESID-alternate []
synonym: "6-phospholysine" EXACT RESID-alternate []
synonym: "N(6)-phosphonolysine" EXACT RESID-alternate []
synonym: "N(epsilon)-phospholysine" EXACT RESID-alternate []
synonym: "N(epsilon)-phosphonolysine" EXACT RESID-alternate []
synonym: "N(epsilon)-phosphonyllysine" EXACT RESID-alternate []
synonym: "N(epsilon)-phosphoryllysine" EXACT RESID-alternate []
synonym: "N6-phospho-L-lysine" EXACT RESID-name []
xref: DiffAvg: "79.98"
xref: DiffFormula: "C 0 H 1 N 0 O 3 P 1"
xref: DiffMono: "79.966331"
xref: Formula: "C 6 H 13 N 2 O 4 P 1"
xref: MassAvg: "208.15"
xref: MassMono: "208.061294"
xref: Origin: "K"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00912 ! modified L-lysine residue
is_a: MOD:01456 ! N-phosphorylated residue

[Term]
id: MOD:01932
name: L-lysinonorleucine
def: "A protein modification that effectively cross-links two lysine residues with a carbon-nitrogen bond to form L-lysinonorleucine.." [PubMed:5117030, PubMed:5817620, PubMed:5879466, PubMed:6030254, RESID:AA0586]
comment: Cross-link 2.
synonym: "(2S)-2-amino-6-([(5S)-5-amino-5-carboxypentyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "(2S,2'S)-6,6'-iminobis(2-aminohexanoic acid)" EXACT RESID-alternate []
synonym: "6-(N6-L-lysino)-L-norleucine" EXACT RESID-alternate []
synonym: "L-lysinonorleucine" EXACT RESID-name []
synonym: "lysinonorleucine" EXACT RESID-alternate []
synonym: "lysinorleucine [misspelling]" EXACT RESID-alternate []
synonym: "lysylnorleucine" EXACT RESID-alternate []
synonym: "N6-[(5S)-5-amino-5-carboxypentyl]-L-lysine" EXACT RESID-alternate []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 12 H 21 N 3 O 2"
xref: MassAvg: "239.32"
xref: MassMono: "239.163377"
xref: Origin: "K, K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:00946 ! crosslinked residues with loss of ammonia

[Term]
id: MOD:01933
name: desmosine
def: "A protein modification that effectively cross-links four L-lysine residues to form desmosine." [ChEBI:37629, PubMed:13941623, PubMed:14109938, PubMed:14109939, PubMed:5839176, RESID:AA0587]
comment: Cross-link 4.
synonym: "4-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium" EXACT RESID-systematic []
synonym: "6-[4-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine" EXACT RESID-alternate []
synonym: "desmosine" EXACT RESID-name []
xref: DiffAvg: "-58.15"
xref: DiffFormula: "C 0 H -16 N -3 O 0"
xref: DiffMono: "-58.134971"
xref: FormalCharge: "1+"
xref: Formula: "C 24 H 32 N 5 O 4"
xref: MassAvg: "454.55"
xref: MassMono: "454.244881"
xref: Origin: "K, K, K, K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01425 ! pyridinyl ring crosslinked residues

[Term]
id: MOD:01934
name: isodesmosine
def: "A protein modification that effectively cross-links four L-lysine residues to form isodesmosine." [ChEBI:37629, PubMed:13941623, PubMed:14109938, PubMed:14109939, PubMed:5839176, RESID:AA0588]
comment: Cross-link 4.
synonym: "2-[(4S)-4-amino-4-carboxybutyl]-1-[(5S)-5-amino-5-carboxypentyl]-3,5-bis[(3S)-3-amino-3-carboxypropyl]pyridinium" EXACT RESID-systematic []
synonym: "6-[2-(4-amino-4-carboxybutyl)-3,5-bis(3-amino-3-carboxypropyl)pyridinio]norleucine" EXACT RESID-alternate []
synonym: "isodesmosine" EXACT RESID-name []
xref: DiffAvg: "-58.15"
xref: DiffFormula: "C 0 H -16 N -3 O 0"
xref: DiffMono: "-58.134971"
xref: FormalCharge: "1+"
xref: Formula: "C 24 H 32 N 5 O 4"
xref: MassAvg: "454.55"
xref: MassMono: "454.244881"
xref: Origin: "K, K, K, K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01425 ! pyridinyl ring crosslinked residues

[Term]
id: MOD:01935
name: O-glucosyl-L-hydroxylysine
def: "modification from RESID" [PubMed:22045808, RESID:AA0589]
synonym: "(D-glucopyranosyl)oxy-L-lysine" EXACT RESID-systematic []
synonym: "O-glucosyl-L-hydroxylysine" EXACT RESID-name []
synonym: "CARBOHYD O-linked (Glc) hydroxylysine" EXACT UniProt-feature []
xref: DiffAvg: "178.14"
xref: DiffFormula: "C 6 H 10 N 0 O 6"
xref: DiffMono: "178.047738"
xref: Formula: "C 12 H 22 N 2 O 7"
xref: MassAvg: "306.32"
xref: MassMono: "306.142701"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0572
relationship: derives_from MOD:01047 ! monohydroxylated lysine
is_a: MOD:00396 ! O-glycosylated residue
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:01936
name: N6-oleoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-oleoyl-L-lysine." [PubMed:20942504, RESID:AA0590]
synonym: "(2S)-2-amino-6-([(9Z)-octadec-9-enoyl]amino)hexanoic acid" EXACT RESID-systematic []
synonym: "N6-[(9Z)-1-oxo-9-octadecenyl]lysine" EXACT RESID-alternate []
synonym: "N6-oleoyl-L-lysine" EXACT RESID-name []
xref: DiffAvg: "264.45"
xref: DiffFormula: "C 18 H 32 N 0 O 1"
xref: DiffMono: "264.245316"
xref: Formula: "C 24 H 44 N 2 O 2"
xref: MassAvg: "392.63"
xref: MassMono: "392.340279"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01875 ! N6-acylated L-lysine
is_a: MOD:02011 ! N-oleoylated residue

[Term]
id: MOD:01937
name: N-palmitoyl-L-methionine
def: "A protein modification that effectively converts an L-methionine residue to N-palmitoyl-L-methionine." [PubMed:20942504, RESID:AA0591]
synonym: "(2S)-2-(hexadecanoylamino)-4-(methylsulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "2-(hexadecanamido)-4-(methylsulfanyl)butanoic acid" EXACT RESID-alternate []
synonym: "LIPID N-palmitoyl methionine" EXACT UniProt-feature []
synonym: "N-(1-oxohexadecyl)methionine" EXACT RESID-alternate []
synonym: "N-palmitoyl-L-methionine" EXACT RESID-name []
xref: DiffAvg: "238.41"
xref: DiffFormula: "C 16 H 30 N 0 O 1 S 0"
xref: DiffMono: "238.229666"
xref: Formula: "C 21 H 40 N 1 O 2 S 1"
xref: MassAvg: "370.62"
xref: MassMono: "370.277976"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00913 ! modified L-methionine residue
is_a: MOD:01685 ! alpha-amino palmitoylated residue

[Term]
id: MOD:01938
name: 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asn)
def: "A protein modification that crosslinks an asparagine and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the release of ammonia." [RESID:AA0592#ASN]
comment: Cross-link 2.
synonym: "(2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid" EXACT RESID-name []
synonym: "aspartimide cysteine" EXACT RESID-alternate []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0 S 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 7 H 8 N 2 O 3 S 1"
xref: MassAvg: "200.21"
xref: MassMono: "200.025563"
xref: Origin: "C, N"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02042 ! crosslinked L-asparagine residue
is_a: MOD:01945 ! 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid
is_a: MOD:00946 ! crosslinked residues with loss of ammonia

[Term]
id: MOD:01939
name: 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid (Asp)
def: "A protein modification that crosslinks an aspartic acid and the following cysteine residue with the formation of (2-aminosuccinimidyl)-3-sulfanylpropanoic acid and the loss of a water molecule." [RESID:AA0592#ASP]
comment: Cross-link 2.
synonym: "(2R)-2-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-3-sulfanylpropanoic acid" EXACT RESID-systematic []
synonym: "2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid" EXACT RESID-name []
synonym: "aspartimide cysteine" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 7 H 8 N 2 O 3 S 1"
xref: MassAvg: "200.21"
xref: MassMono: "200.025563"
xref: Origin: "C, D"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02043 ! crosslinked L-aspartic acid residue
is_a: MOD:01945 ! 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01940
name: 2-(2-aminosuccinimidyl)pentanedioic acid (Asn)
def: "A protein modification that crosslinks an asparagine and the following glutamic acid residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the release of ammonia." [RESID:AA0593#ASN]
comment: Cross-link 2.
synonym: "(4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "2-(2-aminosuccinimidyl)pentanedioic acid" EXACT RESID-name []
synonym: "aspartimide glutamic acid" EXACT RESID-alternate []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 9 H 10 N 2 O 5"
xref: MassAvg: "226.19"
xref: MassMono: "226.058971"
xref: Origin: "E, N"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02042 ! crosslinked L-asparagine residue
is_a: MOD:01946 ! 2-(2-aminosuccinimidyl)pentanedioic acid
is_a: MOD:00946 ! crosslinked residues with loss of ammonia

[Term]
id: MOD:01941
name: 2-(2-aminosuccinimidyl)pentanedioic acid (Asp)
def: "A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)pentanedioic acid and the loss of a water molecule." [RESID:AA0593#ASP]
comment: Cross-link 2.
synonym: "(4S)-4-[(3S)-3-amino-2,5-dioxopyrrolidin-1-yl]-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "2-(2-aminosuccinimidyl)pentanedioic acid" EXACT RESID-name []
synonym: "aspartimide glutamic acid" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 9 H 10 N 2 O 5"
xref: MassAvg: "226.19"
xref: MassMono: "226.058971"
xref: Origin: "D, E"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02043 ! crosslinked L-aspartic acid residue
is_a: MOD:01946 ! 2-(2-aminosuccinimidyl)pentanedioic acid
is_a: MOD:00954 ! crosslinked residues with loss of water

[Term]
id: MOD:01942
name: D-aspartic acid
def: "A protein modification that effectively converts a source amino acid residue to D-aspartic acid." [ChEBI:48094, PubMed:9384562, RESID:AA0190]
synonym: "(2R)-2-aminobutanedioic acid" EXACT RESID-systematic []
synonym: "2-azanylbutanedioic acid" EXACT RESID-alternate []
synonym: "aminosuccinic acid" EXACT RESID-alternate []
synonym: "D-aspartic acid" EXACT RESID-name []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 4 H 5 N 1 O 3"
xref: MassAvg: "115.09"
xref: MassMono: "115.026943"
xref: Origin: "X"
xref: Source: "artifactual"
xref: TermSpec: "none"
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:01943
name: pyrrolidione ring crosslinked residues
def: "A protein modification that crosslinks two adjacent residues by formation of a pyrrolidione ring." [PubMed:18688235]
is_a: MOD:00033 ! crosslinked residues

[Term]
id: MOD:01944
name: 2-aminosuccinimide ring crosslinked residues
def: "A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following residue." [PubMed:18688235]
comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue.
subset: PSI-MOD-slim
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00033 ! crosslinked residues
is_a: MOD:00859 ! modified residue that can arise from different natural residues

[Term]
id: MOD:01945
name: 2-(2-aminosuccinimidyl)-3-sulfanylpropanoic acid
def: "A protein modification that forms (2-aminosuccinimidyl)-3-sulfanylpropanoic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following cysteine residue." [PubMed:18688235]
comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 6 H 6 N 2 O 3"
xref: MassAvg: "154.13"
xref: MassMono: "154.037842"
xref: Origin: "C, X"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:02044 ! crosslinked L-cysteine residue
is_a: MOD:01944 ! 2-aminosuccinimide ring crosslinked residues

[Term]
id: MOD:01946
name: 2-(2-aminosuccinimidyl)pentanedioic acid
def: "A protein modification that forms (2-aminosuccinimidyl)pentanedioicacid by crosslinking either an aspartic acid residue or an asparagine residue with the following glutamic acid\n residue." [PubMed:18688235]
comment: Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue.
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 6 H 6 N 2 O 3"
xref: MassAvg: "154.13"
xref: MassMono: "154.037842"
xref: Origin: "E, X"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:02045 ! crosslinked L-glutamic acid residue
is_a: MOD:01944 ! 2-aminosuccinimide ring crosslinked residues

[Term]
id: MOD:01947
name: O-(L-isoaspartyl)-L-threonine (cross-link)
def: "A protein modification that effectively cross-links an L-threonine residue and an L-aspartic acid residue with an ester bond to form  O-(L-isoaspartyl)-L-threonine." [PubMed:17157318, PubMed:8706862, RESID:AA0525#TDX]
comment: Cross-link 2.
synonym: "(2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "(2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid" EXACT RESID-alternate []
synonym: "CROSSLNK isoaspartyl threonine ester (Thr-Asp)" EXACT UniProt-feature []
synonym: "O(beta)-(beta-aspartyl)threonine" EXACT RESID-alternate []
synonym: "O-(L-isoaspartyl)-L-threonine" EXACT RESID-name []
synonym: "O3-(isoaspartyl)-threonine" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1"
xref: DiffMono: "-18.010565"
xref: Formula: "C 8 H 10 N 2 O 4"
xref: MassAvg: "198.18"
xref: MassMono: "198.064057"
xref: Origin: "D, T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00885 ! ester crosslinked residues
is_a: MOD:02043 ! crosslinked L-aspartic acid residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01978 ! O-(L-isoaspartyl)-L-threonine

[Term]
id: MOD:01948
name: labionin
def: "A protein modification that effectively cross-links an L-cysteine residue and two L-serine residues by a thioether bond and a carbon-carbon bond to form labionin." [PubMed:20082397, RESID:AA0594]
comment: Cross-link 3.
synonym: "(2S,4S)-2,4-diamino-2-[([(2R)-2-amino-2-carboxyethyl]sulfanyl)methyl]pentanedioic acid" EXACT RESID-systematic []
synonym: "(2S,4S,8R)-2,4,8-triamino-4-carboxy-6-thianonanedioic acid" EXACT RESID-alternate []
synonym: "(2S,4S,8R)-labionin" EXACT RESID-alternate []
synonym: "labionin" EXACT RESID-name []
xref: DiffAvg: "-36.03"
xref: DiffFormula: "C 0 H -4 N 0 O -2 S 0"
xref: DiffMono: "-36.021129"
xref: Formula: "C 9 H 11 N 3 O 3 S 1"
xref: MassAvg: "241.26"
xref: MassMono: "241.052112"
xref: Origin: "C, S, S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01993 ! beta-carbon thioether crosslinked residues

[Term]
id: MOD:01949
name: coelenterazine
def: "A protein modification that effectively cross-links a phenylalanine and two tyrosine residues to form coelenterazine." [ChEBI:2311, PubMed:10830969, PubMed:11572972, PubMed:19833098, RESID:AA0595]
comment: Cross-link 3.
synonym: "8-benzyl-2-(4-hydroxybenzyl)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one" EXACT RESID-systematic []
synonym: "coelenterazine" EXACT RESID-name []
synonym: "Oplophorus luciferin" EXACT RESID-alternate []
xref: DiffAvg: "-50.06"
xref: DiffFormula: "C -1 H -6 N 0 O -2"
xref: DiffMono: "-50.036779"
xref: Formula: "C 26 H 21 N 3 O 3"
xref: MassAvg: "423.47"
xref: MassMono: "423.158292"
xref: Origin: "F, Y, Y"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
is_a: MOD:00033 ! crosslinked residues
is_a: MOD:02053 ! crosslinked L-phenylalanine residue
is_a: MOD:02058 ! crosslinked L-tyrosine residue

[Term]
id: MOD:01950
name: L-isoglutamyl histamine
def: "A protein modification that effectively converts an L-glutamine residue to L-isoglutamyl histamine." [PubMed:23022564, RESID:AA0596]
synonym: "(2S)-2-amino-5-([2-(1H-imidazol-5-yl)ethyl]amino)-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "(gamma-glutamyl)histamine" EXACT RESID-alternate []
synonym: "L-isoglutamyl histamine" EXACT RESID-name []
xref: DiffAvg: "94.12"
xref: DiffFormula: "C 5 H 6 N 2 O 0"
xref: DiffMono: "94.053098"
xref: Formula: "C 10 H 14 N 4 O 2"
xref: MassAvg: "222.25"
xref: MassMono: "222.111676"
xref: Origin: "Q"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0488
is_a: MOD:00907 ! modified L-glutamine residue

[Term]
id: MOD:01951
name: O-(L-isoglutamyl)-L-serine (Gln-Ser)
def: "A protein modification that effectively crosslinks an L-glutamine residue and an L-serine residue by an ester bond and releasing ammonia to form O-(L-isoglutamyl)-L-serine." [PubMed:17051152, RESID:AA0597#QSX]
comment: Cross-link 2.
synonym: "(2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "O(beta)-(gamma-glutamyl)serine" EXACT RESID-alternate []
synonym: "O-(L-isoglutamyl)-L-serine" EXACT RESID-name []
synonym: "O3-(isoglutamyl)-serine" EXACT RESID-alternate []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 8 H 10 N 2 O 4"
xref: MassAvg: "198.18"
xref: MassMono: "198.064057"
xref: Origin: "Q, S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02046 ! crosslinked L-glutamine residue
is_a: MOD:00946 ! crosslinked residues with loss of ammonia
is_a: MOD:01977 ! O-(L-isoglutamyl)-L-serine

[Term]
id: MOD:01952
name: O-(L-isoglutamyl)-L-threonine (Gln-Thr)
def: "A protein modification that effectively cross-links an L-threonine residue and an L-glutamine residue with an ester bond releasing ammonia to form O-(L-isoglutamyl)-L-threonine." [PubMed:17051152, RESID:AA0536#TQX]
comment: Cross-link 2.
synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate []
synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate []
synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate []
synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name []
synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate []
xref: DiffAvg: "-17.03"
xref: DiffFormula: "C 0 H -3 N -1 O 0"
xref: DiffMono: "-17.026549"
xref: Formula: "C 9 H 12 N 2 O 4"
xref: MassAvg: "212.20"
xref: MassMono: "212.079707"
xref: Origin: "Q, T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02046 ! crosslinked L-glutamine residue
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:01979 ! O-(L-isoglutamyl)-L-threonine
is_a: MOD:00885 ! ester crosslinked residues
is_a: MOD:00946 ! crosslinked residues with loss of ammonia

[Term]
id: MOD:01953
name: tetrakis-L-cysteinyl tetrairon octanitrosyl
def: "A protein modification that effectively converts four L-cysteine residues and a four-iron cluster to tetrakis-L-cysteinyl tetrairon octanitrosyl." [PubMed:21182249, RESID:AA0599]
comment: Cross-link 4.
xref: DiffAvg: "459.40"
xref: DiffFormula: "C 0 Fe 4 H -4 N 8 O 8 S 0"
xref: DiffMono: "459.692359"
xref: Formula: "C 12 Fe 4 H 16 N 12 O 12 S 4"
xref: MassAvg: "871.95"
xref: MassMono: "871.729098"
xref: Origin: "C, C, C, C"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00738 ! iron containing modified residue
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:01954
name: dehydroalanine (Sec)
def: "A protein modification that effectively converts an L-selenocysteine residue to dehydroalanine." [ChEBI:17123, PubMed:10220322, PubMed:12781460, PubMed:1547888, PubMed:1815586, PubMed:20805503, PubMed:21420488, PubMed:22031445, PubMed:2914619, PubMed:7947813, PubMed:8239649, RESID:AA0181]
synonym: "2,3-didehydroalanine" EXACT RESID-alternate []
synonym: "2-aminoacrylic acid" EXACT RESID-alternate []
synonym: "2-aminopropenoic acid" EXACT RESID-systematic []
synonym: "4-methylidene-imidazole-5-one (MIO) active site" EXACT RESID-alternate []
synonym: "anhydroserine" EXACT RESID-alternate []
synonym: "dehydroalanine" EXACT RESID-name []
synonym: "Dha" EXACT RESID-alternate []
xref: DiffAvg: "-80.99"
xref: DiffFormula: "C 0 H -2 N 0 O 0 Se -1"
xref: DiffMono: "-81.932171"
xref: Formula: "C 3 H 3 N 1 O 1"
xref: MassAvg: "69.06"
xref: MassMono: "69.021464"
xref: Origin: "U"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01158 ! modified L-selenocysteine residue
is_a: MOD:01168 ! dehydroalanine

[Term]
id: MOD:01955
name: L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide
def: "modification from RESID" [PubMed:21499260, RESID:AA0600]
comment: Cross-link 7.
synonym: "4Mn-Ca-5O cluster" EXACT RESID-alternate []
synonym: "L-alaninato bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese pentoxide" EXACT RESID-name []
synonym: "mu2-alaninato-1kappaO(1),3kappaO(1')-mu2-aspartato-1kappaO(4),5kappaO(4')-mu2-aspartato-2kappaO(4),3kappaO(4')-mu2-glutamato-3kappaO(5),4kappaO(5')-mu2-glutamato-4kappaO(5),5kappaO(5')-mu-glutamato-2kappaO(5)-mu-histidino-2kappaN(tau)-mu4-oxido-1:2:4:5kappa(4)O-tri-mu3-oxido-1:2:3kappa(3)O;1:3:4kappa(3)O;2:3:4kappa(3)O;mu-oxido-4:5kappa(2)O-calciumtetramanganese" EXACT RESID-systematic []
synonym: "photosystem II catalytic cluster" EXACT RESID-alternate []
xref: DiffAvg: "333.78"
xref: DiffFormula: "C 0 Ca 1 H -6 Mn 4 N 0 O 5"
xref: DiffMono: "333.642394"
xref: Formula: "C 32 Ca 1 H 38 Mn 4 N 9 O 23"
xref: MassAvg: "1176.53"
xref: MassMono: "1175.922825"
xref: Origin: "A, D, D, E, E, E, H"
xref: Source: "natural"
xref: TermSpec: "C-term"
is_a: MOD:00740 ! manganese containing modified residue
is_a: MOD:01482 ! calcium containing modified residue
is_a: MOD:02065 ! metal or metal cluster coordinated L-alanine residue
is_a: MOD:02066 ! metal or metal cluster coordinated L-aspartic acid residue
is_a: MOD:02068 ! metal or metal cluster coordinated L-glutamic acid residue
is_a: MOD:02070 ! metal or metal cluster coordinated L-histidine residue

[Term]
id: MOD:01956
name: (3R)-3-hydroxy-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to (3R)-3-hydroxy-L-arginine." [PubMed:10094780, PubMed:23103944, PubMed:786730, RESID:AA0601]
synonym: "(2S,3R)-2-amino-5-[(diaminomethylidene)amino]-3-hydroxypentanoic acid" EXACT RESID-systematic []
synonym: "(3R)-3-hydroxy-L-arginine" EXACT RESID-name []
synonym: "2-amino-5-(carbamimidamido)-3-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "2-amino-5-[(aminoiminomethyl)amino]-3-hydroxypentanoic acid [tautomer]" EXACT RESID-alternate []
synonym: "2-amino-5-guanidino-3-hydroxypentanoic acid" EXACT RESID-alternate []
synonym: "beta-hydroxyarginine" EXACT RESID-alternate []
synonym: "C(beta)-hydroxyarginine" EXACT RESID-alternate []
synonym: "MOD_RES (3R)-3-hydroxyarginine" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 6 H 12 N 4 O 2"
xref: MassAvg: "172.19"
xref: MassMono: "172.096026"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0476
is_a: MOD:00682 ! hydroxylated arginine

[Term]
id: MOD:01957
name: 2-hydroxyproline
def: "A protein modification that effectively converts an L-proline residue to 2-hydroxyproline." [PubMed:23385463, RESID:AA0602, ChEBI:141809]
synonym: "(2R)-2-hydroxypyrrolidine-2-carboxylic acid" EXACT RESID-systematic []
synonym: "2-hydroxyproline" EXACT RESID-name []
synonym: "2-oxidanylpyrrolidine-2-carboxylic acid" EXACT RESID-alternate []
synonym: "alpha-hydroxyproline" EXACT RESID-alternate []
synonym: "MOD_RES 2-hydroxyproline" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 7 N 1 O 2"
xref: MassAvg: "113.12"
xref: MassMono: "113.047678"
xref: Origin: "P"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0668
is_a: MOD:01024 ! monohydroxylated proline

[Term]
id: MOD:01958
name: bis-L-cysteinyl bisglutathion-S-yl diiron disulfide
def: "A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bisglutathion-S-yl diiron disulfide." [PubMed:17121859, RESID:AA0603]
comment: Cross-link 2.
synonym: "bis-L-cysteinyl bisglutathion-S-yl diiron disulfide" EXACT RESID-name []
synonym: "di-mu-sulfido-bis(cysteinato)-1kappaS,2kappaS-bis(glutathionato)-1kappaS,2kappaS-diiron" EXACT RESID-systematic []
synonym: "mitochondrial glutaredoxin 2 dimer iron-sulfur cluster" EXACT RESID-alternate []
synonym: "plant glutaredoxin C1 dimer iron-sulfur cluster" EXACT RESID-alternate []
xref: DiffAvg: "786.42"
xref: DiffFormula: "C 20 Fe 2 H 30 N 6 O 12 S 4"
xref: DiffMono: "785.950329"
xref: Formula: "C 26 Fe 2 H 40 N 8 O 14 S 6"
xref: MassAvg: "992.70"
xref: MassMono: "991.968699"
xref: Origin: "C, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue

[Term]
id: MOD:01959
name: tris-L-cysteinyl L-glutamato tetrairon tetrasulfide
def: "A protein modification that effectively converts three L-cysteine residues, an L-glutamic acid and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamato tetrairon tetrasulfide." [PubMed:21167158, RESID:AA0604]
comment: Cross-link 4.
synonym: "tris-L-cysteinyl L-glutamato tetrairon tetrasulfide" EXACT RESID-name []
synonym: "tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutamato-4kappaO(5),4kappaO(5')-tetrairon" EXACT RESID-systematic []
xref: DiffAvg: "347.59"
xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4"
xref: DiffMono: "347.596734"
xref: Formula: "C 14 Fe 4 H 18 N 4 O 6 S 7"
xref: MassAvg: "786.12"
xref: MassMono: "785.666881"
xref: Origin: "C, C, C, E"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02068 ! metal or metal cluster coordinated L-glutamic acid residue

[Term]
id: MOD:01960
name: tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide
def: "A protein modification that effectively converts three L-cysteine residues, an L-glutamine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide." [PubMed:11796730, RESID:AA0605]
comment: Cross-link 4.
synonym: "METAL Iron-sulfur (4Fe-4S)" EXACT UniProt-feature []
synonym: "tris-L-cysteinyl L-glutamin-O6-yl tetrairon tetrasulfide" EXACT RESID-name []
synonym: "tris-mu3-sulfido-tris(cysteinato)-1kappaS,2kappaS,3kappaS-glutaminato-4kappaN(5)-tetrairon" EXACT RESID-systematic []
xref: DiffAvg: "347.59"
xref: DiffFormula: "C 0 Fe 4 H -4 N 0 O 0 S 4"
xref: DiffMono: "347.596734"
xref: Formula: "C 14 Fe 4 H 19 N 5 O 5 S 7"
xref: MassAvg: "785.14"
xref: MassMono: "784.682866"
xref: Origin: "C, C, C, Q"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00739 ! iron-sulfur cluster containing modification
is_a: MOD:02067 ! metal or metal cluster coordinated L-cysteine residue
is_a: MOD:02069 ! metal or metal cluster coordinated L-glutamine residue

[Term]
id: MOD:01961
name: O-(L-isoglutamyl)-L-threonine (THR)
def: "OBSOLETE because redundant and identical to MOD:01785. Remap to MOD:01785." [PubMed:16618936, PubMed:17051152, PubMed:17687277, PubMed:18555071, RESID:AA0536#THR]
synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate []
synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate []
synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate []
synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name []
synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate []
xref: DiffAvg: "129.12"
xref: DiffFormula: "C 5 H 7 N 1 O 3"
xref: DiffMono: "129.042593"
xref: Formula: "C 9 H 14 N 2 O 5"
xref: MassAvg: "230.22"
xref: MassMono: "230.090272"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:01785"
is_obsolete: true

[Term]
id: MOD:01962
name: N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine
def: "A protein modification that effectively converts an L-asparagine residue to N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine." [PubMed:12186869, PubMed:19236052, RESID:AA0606]
synonym: "(2S)-2-amino-4-[(2,4-diacetylamino-2,4,6-trideoxy-beta-D-glucopyranosyl)amino]-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "DABA" EXACT RESID-alternate []
synonym: "DATDH" EXACT RESID-alternate []
synonym: "DiNAcBac" EXACT RESID-alternate []
synonym: "N4-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-asparagine" EXACT RESID-name []
synonym: "N4-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-asparagine" EXACT RESID-alternate []
synonym: "N4-[N,N-diacetylbacillosaminyl]asparagine" EXACT RESID-alternate []
synonym: "N4-[N2,N4-diacetylbacillosaminyl]asparagine" EXACT RESID-alternate []
synonym: "CARBOHYD N-linked (DATDGlc) asparagine" EXACT UniProt-feature []
xref: DiffAvg: "228.25"
xref: DiffFormula: "C 10 H 16 N 2 O 4"
xref: DiffMono: "228.111007"
xref: Formula: "C 14 H 22 N 4 O 6"
xref: MassAvg: "342.35"
xref: MassMono: "342.153934"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0506
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:01963
name: O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine." [PubMed:23030644, RESID:AA0607]
synonym: "(2S)-2-amino-4-[(2,4-diacetamido-2,4,6-trideoxy-beta-D-glucopyranosyl)oxy]propanoic acid" EXACT RESID-systematic []
synonym: "DABA" EXACT RESID-alternate []
synonym: "DATDH" EXACT RESID-alternate []
synonym: "DiNAcBac" EXACT RESID-alternate []
synonym: "O-(2,4-diacetamido-2,4,6-trideoxy-D-glucosyl)-L-serine" EXACT RESID-name []
synonym: "O-[2,4-bis(acetylamino)-2,4,6-trideoxy-beta-D-glucopyranosyl]-L-serine" EXACT RESID-alternate []
synonym: "O-[N,N-diacetylbacillosaminyl]serine" EXACT RESID-alternate []
synonym: "O-[N2,N4-diacetylbacillosaminyl]serine" EXACT RESID-alternate []
synonym: "CARBOHYD O-linked (DATDGlc) serine" EXACT UniProt-feature []
xref: DiffAvg: "228.25"
xref: DiffFormula: "C 10 H 16 N 2 O 4"
xref: DiffMono: "228.111007"
xref: Formula: "C 13 H 21 N 3 O 6"
xref: MassAvg: "315.33"
xref: MassMono: "315.143035"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0548
is_a: MOD:00002 ! O-glycosyl-L-serine

[Term]
id: MOD:01964
name: O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine
def: "A protein modification that effectively converts an L-serine residue to O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine." [PubMed:17804791, RESID:AA0608]
synonym: "(2S)-2-amino-3-[(2-acetamido-4-glycerylamino-2,4,6-trideoxy-D-glucopyranosyl)oxy]propanoic acid" EXACT RESID-systematic []
synonym: "GATDH" EXACT RESID-alternate []
synonym: "O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucopyranosyl)-L-serine" EXACT RESID-alternate []
synonym: "O-(2-acetamido-4-glyceramido-2,4,6-trideoxy-D-glucosyl)-L-serine" EXACT RESID-name []
synonym: "O-(N2-acetyl-N4-glycerylbacillosaminyl)-L-serine" EXACT RESID-alternate []
synonym: "CARBOHYD O-linked (GATDGlc) serine" EXACT UniProt-feature []
xref: DiffAvg: "274.27"
xref: DiffFormula: "C 11 H 18 N 2 O 6"
xref: DiffMono: "274.116486"
xref: Formula: "C 14 H 23 N 3 O 8"
xref: MassAvg: "361.35"
xref: MassMono: "361.148515"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0549
is_a: MOD:00002 ! O-glycosyl-L-serine

[Term]
id: MOD:01965
name: 2xC(13),3x(2)H labeled N6-acetyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to 2xC(13),3x(2)H labeled N6-acetyl-L-lysine." [PubMed:18688235]
synonym: "Acetate labeling reagent (K) (heavy form, +5amu)" EXACT PSI-MOD-alternate []
synonym: "COFRADIC heavy acetyl 13C2 2H3" EXACT PSI-MOD-alternate []
xref: DiffAvg: "47.04"
xref: DiffFormula: "(13)C 2 (1)H -1 (2)H 3 O 1"
xref: DiffMono: "47.036105"
xref: Formula: "(12)C 6 (13)C 2 (1)H 11 (2)H 3 N 2 O 2"
xref: MassAvg: "175.13"
xref: MassMono: "175.131068"
xref: Origin: "K"
xref: Source: "artifact"
xref: TermSpec: "none"
relationship: derives_from MOD:00064 ! N6-acetyl-L-lysine
is_a: MOD:01428 ! (13)C isotope tagged reagent
is_a: MOD:01431 ! (2)H deuterium tagged reagent

[Term]
id: MOD:01966
name: L-methionine (R)-sulfoxide
def: "OBSOLETE because redundant and identical to MOD:00720. Remap to MOD:00720." [ChEBI:45764, PubMed:21406390, PubMed:22116028, PubMed:23911929, RESID:AA0581]
synonym: "(2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid" EXACT RESID-systematic []
synonym: "L-methionine (R)-S-oxide" EXACT RESID-alternate []
synonym: "L-methionine (R)-sulfoxide" EXACT RESID-name []
synonym: "MOD_RES Methionine (R)-sulfoxide" EXACT UniProt-feature []
xref: DiffAvg: "16.00"
xref: DiffFormula: "C 0 H 0 N 0 O 1 S 0"
xref: DiffMono: "15.994915"
xref: Formula: "C 5 H 9 N 1 O 2 S 1"
xref: MassAvg: "147.19"
xref: MassMono: "147.035400"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Remap: "MOD:00720"
is_obsolete: true

[Term]
id: MOD:01967
name: omega-N-(N-acetylamino)glucosyl-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to  omega-N-(N-acetylamino)glucosyl-L-arginine." [PubMed:23955153, RESID:AA0609]
synonym: "(2S)-2-amino-5-[(amino[(2-N-acetylamino-2-deoxy-D-glucopyranosyl)amino]methylidene)amino]pentanoic acid" EXACT RESID-systematic []
synonym: "N(omega)-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate []
synonym: "N(omega)-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate []
synonym: "N(omega)-(2-N-acetylaminoglucosyl)arginine" EXACT RESID-alternate []
synonym: "NG-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate []
synonym: "NG-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate []
synonym: "NG-(2-N-acetylaminoglucosyl)arginine" EXACT RESID-alternate []
synonym: "omega-N-(2-acetamido-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate []
synonym: "omega-N-(2-acetylamino-2-deoxy-D-glucopyranosyl)-L-arginine" EXACT RESID-alternate []
synonym: "omega-N-(2-N-acetylaminoglucosyl)arginine" EXACT RESID-alternate []
synonym: "omega-N-(N-acetylamino)glucosyl-L-arginine" EXACT RESID-name []
synonym: "CARBOHYD N-linked (GlcNAc) arginine" EXACT UniProt-feature []
xref: DiffAvg: "203.19"
xref: DiffFormula: "C 8 H 13 N 1 O 5"
xref: DiffMono: "203.079373"
xref: Formula: "C 14 H 25 N 5 O 6"
xref: MassAvg: "359.38"
xref: MassMono: "359.180484"
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0518
is_a: MOD:00448 ! mono-N-acetylaminoglucosylated residue
is_a: MOD:01980 ! omega-N-glycosyl-L-arginine

[Term]
id: MOD:01968
name: (2R,3R,2'R)-3-methyllanthionine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2R,3R,2'R)-3-methyllanthionine." [PubMed:23314913, RESID:AA0610]
comment: Cross-link 2.
synonym: "(2R,3R)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid" EXACT RESID-systematic []
synonym: "(2R,3R,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT RESID-alternate []
synonym: "(2R,3R,2'R)-3-methyllanthionine" EXACT RESID-name []
synonym: "(2R,3R,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid" EXACT RESID-alternate []
synonym: "(2R,3R,6R)-3-methyllanthionine" EXACT RESID-alternate []
synonym: "2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid" EXACT RESID-alternate []
synonym: "3-methyl-L,L-lanthionine" EXACT RESID-alternate []
synonym: "cysteine-3-L-butyrine thioether" EXACT RESID-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 7 H 10 N 2 O 2 S 1"
xref: MassAvg: "186.23"
xref: MassMono: "186.046299"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01981 ! 3-methyllanthionine

[Term]
id: MOD:01969
name: S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine." [PubMed:9398217, RESID:AA0611]
synonym: "(2S)-2-amino-5-([(2R)-1-([2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-2-oxoethyl]amino)-1-oxo-3-sulfanylpropan-2-yl]amino)-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "ACT_SITE S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine intermediate" EXACT UniProt-feature []
synonym: "S-(gamma-glutamyl-cysteinyl-glycyl)-cysteine" EXACT RESID-name []
synonym: "S-(glutathion-1-yl)-L-cysteine" EXACT RESID-alternate []
xref: DiffAvg: "289.31"
xref: DiffFormula: "C 10 H 15 N 3 O 5 S 1"
xref: DiffMono: "289.073242"
xref: Formula: "C 13 H 20 N 4 O 6 S 2"
xref: MassAvg: "392.44"
xref: MassMono: "392.082426"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00860 ! sulfur containing modified residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01970
name: 5-glutamyl glutamic acid
def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl glutamic acid, forming an isopeptide bond with a free glutamic acid." [PubMed:10747868, PubMed:15525938, PubMed:1680872, PubMed:23434852, RESID:AA0612, Unimod:450]
synonym: "(2S)-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanedioic acid" EXACT RESID-systematic []
synonym: "(2S)-2-[(4S)-4-amino-4-carboxybutanamido]pentanedioic acid" EXACT RESID-alternate []
synonym: "2-([4-azanyl-4-carboxybutanoyl]azanyl)pentanedioic acid" EXACT RESID-alternate []
synonym: "5-glutamyl glutamic acid" EXACT RESID-name []
synonym: "gamma-glutamylglutamate" EXACT RESID-alternate []
synonym: "Glu" RELATED Unimod-interim []
synonym: "isoglutamyl glutamic acid" EXACT RESID-alternate []
synonym: "isoglutamyl monoglutamic acid" EXACT RESID-alternate []
synonym: "MOD_RES 5-glutamyl glutamate" EXACT UniProt-feature []
synonym: "monoglutamyl" RELATED Unimod-description []
synonym: "N alpha -(gamma-Glutamyl)-Glu" EXACT DeltaMass-label []
synonym: "N-(gamma-L-glutamyl)-L-glutamic acid" EXACT RESID-alternate []
xref: DiffAvg: "129.12"
xref: DiffFormula: "C 5 H 7 N 1 O 3"
xref: DiffMono: "129.042593"
xref: Formula: "C 10 H 14 N 2 O 6"
xref: MassAvg: "258.23"
xref: MassMono: "258.085186"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:450"
xref: uniprot.ptm:PTM-0479
is_a: MOD:00207 ! L-isoglutamyl-polyglutamic acid

[Term]
id: MOD:01971
name: 5-glutamyl N2-ornithine
def: "A protein modification that effectively converts an L-glutamic acid residue to N2-ornithine." [PubMed:23434852, RESID:AA0613, ChEBI:136763]
synonym: "(2S)-5-amino-2-([(4S)-4-amino-4-carboxybutanoyl]amino)pentanoic acid" EXACT RESID-alternate []
synonym: "(2S)-5-amino-2-[(4S)-4-amino-4-carboxybutanamido]pentanoic acid" EXACT RESID-systematic []
synonym: "4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-ketovaleric acid" EXACT RESID-alternate []
synonym: "4-amino-5-[(4-amino-1-carboxy-butyl)amino]-5-oxopentanoic acid" EXACT RESID-alternate []
synonym: "5-glutamyl N2-ornithine" EXACT RESID-name []
synonym: "gamma-glutamylornithine" EXACT RESID-alternate []
synonym: "MOD_RES 5-glutamyl N2-ornithine" EXACT UniProt-feature []
synonym: "N2-(gamma-glutamyl)ornithine" EXACT RESID-alternate []
synonym: "N2-(L-isoglutamyl)-L-ornithine" EXACT RESID-alternate []
xref: DiffAvg: "114.15"
xref: DiffFormula: "C 5 H 10 N 2 O 1"
xref: DiffMono: "114.079313"
xref: Formula: "C 10 H 17 N 3 O 4"
xref: MassAvg: "243.26"
xref: MassMono: "243.121906"
xref: Origin: "E"
xref: Source: "hypothetical"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0478
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:01972
name: 5-glutamyl coenzyme A thioester
def: "A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl coenzyme A thioester." [PubMed:16253988, PubMed:20977214, PubMed:7915164, RESID:AA0614]
synonym: "(2S)-2-amino-5-(2-[([3-([(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanoyl]-amino)-propanoyl]-amino)-ethyl]-sulfanyl)-5-oxopentanoic acid" EXACT RESID-alternate []
synonym: "(2S)-2-amino-5-([2-(3-[(2R)-2-hydroxy-3,3-dimethyl-4-([3'-phospho-adenosyl-5'-diphosphoryl]-oxy)-butanamido]-propanamido)-ethyl]-sulfanyl)-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "5-glutamyl 4-[(3'-phospho-adenosyl-5'-diphosphoryl)oxy]pantetheine thioester" EXACT RESID-alternate []
synonym: "5-glutamyl coenzyme A thioester" EXACT RESID-name []
synonym: "5-glutamyl coenzyme A thioester intermediate" EXACT UniProt-feature []
xref: DiffAvg: "749.52"
xref: DiffFormula: "C 21 H 34 N 7 O 15 P 3 S 1"
xref: DiffMono: "749.104644"
xref: Formula: "C 26 H 41 N 8 O 18 P 3 S 1"
xref: MassAvg: "878.63"
xref: MassMono: "878.147237"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00860 ! sulfur containing modified residue
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:01973
name: N6-(3-phosphoglyceryl)-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-(3-phosphoglyceryl)-L-lysine." [PubMed:23908237, RESID:AA0615]
synonym: "(2S)-2-amino-6-([(2R)-2-hydroxy-3-(phosphonooxy)propanoyl]amino)hexanoic acid" EXACT RESID-alternate []
synonym: "(2S)-2-amino-6-[(2R)-2-hydroxy-3-(phosphonooxy)propanamido]hexanoic acid" EXACT RESID-systematic []
synonym: "3-phosphoglyceryl-lysine" EXACT RESID-alternate []
synonym: "N6-(3-phosphoglyceryl)-L-lysine" EXACT RESID-name []
xref: DiffAvg: "168.04"
xref: DiffFormula: "C 3 H 5 N 0 O 6 P 1"
xref: DiffMono: "167.982375"
xref: Formula: "C 9 H 17 N 2 O 7 P 1"
xref: MassAvg: "296.22"
xref: MassMono: "296.077338"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00861 ! phosphorus containing modified residue
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:01974
name: S-methyl-L-methionine
def: "A protein modification that effectively converts an L-methionine residue to S-methyl-L-methionine." [ChEBI:17728, PubMed:23532849, RESID:AA0616]
synonym: "(2S)-2-amino-4-(dimethylsulfonio)butanoate" EXACT RESID-alternate []
synonym: "(3S)-(3-amino-3-carboxypropyl)dimethylsulfanium" EXACT RESID-systematic []
synonym: "[(3S)-3-amino-3-carboxypropyl](dimethyl)sulfonium" EXACT RESID-alternate []
synonym: "S-methyl-L-methionine" EXACT RESID-name []
synonym: "S-methylmethionine" EXACT RESID-alternate []
synonym: "S-methylmethioninium" EXACT RESID-alternate []
synonym: "vitamin U" EXACT RESID-alternate []
xref: DiffAvg: "15.03"
xref: DiffFormula: "C 1 H 3 N 0 O 0 S 0"
xref: DiffMono: "15.022927"
xref: FormalCharge: "1+"
xref: Formula: "C 6 H 12 N 1 O 1 S 1"
xref: MassAvg: "146.23"
xref: MassMono: "146.063411"
xref: Origin: "M"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0636
is_a: MOD:00716 ! methylated methionine

[Term]
id: MOD:01975
name: S-poly(3-hydroxybutyrate)-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to S-(poly-3-hydroxybutyrate)-L-cysteine." [PubMed:19711985, PubMed:9888824, RESID:AA0617]
synonym: "(alpha)-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-(omega)-[(3R)-3-hydroxybutanoyl]-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy)" EXACT RESID-systematic []
synonym: "S-poly(3-hydroxybutanoate)cysteine" EXACT RESID-alternate []
synonym: "S-poly(3-hydroxybutanoic acid)cysteine" EXACT RESID-alternate []
synonym: "S-poly(3-hydroxybutyrate)-L-cysteine" EXACT RESID-name []
synonym: "S-poly(3-hydroxybutyrate)cysteine" EXACT RESID-alternate []
synonym: "S-poly(3-hydroxybutyric acid)cysteine" EXACT RESID-alternate []
synonym: "S-poly(beta-hydroxybutyrate)cysteine" EXACT RESID-alternate []
synonym: "S-poly[(R)-3-hydroxybutyrate]cysteine" EXACT RESID-alternate []
synonym: "MOD_RES S-poly(beta-hydroxybutyryl)lysine" EXACT UniProt-feature []
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0641
is_a: MOD:00672 ! S-acylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:01976
name: O3-(poly-3-hydroxybutyrate)-L-serine
def: "A protein modification that effectively converts an L-serine residue to O3-(poly-3-hydroxybutyrate)-L-serine." [PubMed:17659252, PubMed:20004640, RESID:AA0618]
subset: PSI-MOD-slim
synonym: "(2S)-2-amino-3-[([(3R)-3-hydroxybutanoyl]oxy)-poly([(3R)-3-methyl-1-oxopropane-1,3-diyl]oxy)]propanoic acid" EXACT RESID-systematic []
synonym: "O3-(poly-3-hydroxybutyrate)-L-serine" EXACT RESID-name []
synonym: "O3-poly(3-hydroxybutanoate)serine" EXACT RESID-alternate []
synonym: "O3-poly(3-hydroxybutanoic acid)serine" EXACT RESID-alternate []
synonym: "O3-poly(3-hydroxybutyrate)serine" EXACT RESID-alternate []
synonym: "O3-poly(3-hydroxybutyric acid)serine" EXACT RESID-alternate []
synonym: "O3-poly(beta-hydroxybutyrate)serine" EXACT RESID-alternate []
synonym: "O3-poly[(R)-3-hydroxybutyrate]serine" EXACT RESID-alternate []
synonym: "MOD_RES O3-poly(beta-hydroxybutyryl)lysine" EXACT UniProt-feature []
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0640
is_a: MOD:00671 ! O-acylated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:01977
name: O-(L-isoglutamyl)-L-serine
def: "A protein modification that effectively crosslinks either an L-glutamine residue or an L-glutamic acid residue with an L-serine residue by an ester bond  to form O-(L-isoglutamyl)-L-serine." [PubMed:17051152, RESID:AA0597]
comment: Cross-link 2.
synonym: "(2S)-2-amino-5-[(2S)-2-amino-2-carboxyethoxy]-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "O(beta)-(gamma-glutamyl)serine" EXACT RESID-alternate []
synonym: "O-(L-isoglutamyl)-L-serine" EXACT RESID-name []
synonym: "O3-(isoglutamyl)-serine" EXACT RESID-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 8 H 10 N 2 O 4"
xref: MassAvg: "198.18"
xref: MassMono: "198.064057"
xref: Origin: "S, X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:00885 ! ester crosslinked residues
is_a: MOD:02055 ! crosslinked L-serine residue

[Term]
id: MOD:01978
name: O-(L-isoaspartyl)-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using either free L-asparagine and releasing ammonia or using a peptidyl L-aspartic acid residue and releasing water." [PubMed:8706862, RESID:AA0525]
comment: This is a threonine active intermediate and not an ester cross-link of peptides [JSG].
synonym: "(2S)-2-amino-4-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "(2S,3R)-2-amino-3-([(4S)-3-amino-3-carboxypropanoyl]oxy)propanoic acid" EXACT RESID-alternate []
synonym: "O(beta)-(beta-aspartyl)threonine" EXACT RESID-alternate []
synonym: "O-(L-isoaspartyl)-L-threonine" EXACT RESID-name []
synonym: "O3-(isoaspartyl)-threonine" EXACT RESID-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 8 H 12 N 2 O 5"
xref: MassAvg: "216.19"
xref: MassMono: "216.074621"
xref: Origin: "T, X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:02056 ! crosslinked L-threonine residue

[Term]
id: MOD:01979
name: O-(L-isoglutamyl)-L-threonine
def: "A protein modification that effectively converts an L-threonine residue to O-(L-isoglutamyl)-L-threonine, using free L-glutamine and releasing ammonia, or using a peptidyl L-glutamine and releasing ammonia." [PubMed:8706862, RESID:AA0536]
comment: This is not an ester cross-link of peptides [JSG].
synonym: "(2S)-2-amino-5-([(1S,2R)-1-amino-1-carboxypropan-2-yl]oxy)-5-oxopentanoic acid" EXACT RESID-systematic []
synonym: "(2S,3R)-2-amino-3-([(4S)-4-amino-4-carboxybutanoyl]oxy)-propanoic acid" EXACT RESID-alternate []
synonym: "5-(threon-O3-yl)glutamate" EXACT RESID-alternate []
synonym: "O(beta)-(gamma-glutamyl)threonine" EXACT RESID-alternate []
synonym: "O-(L-isoglutamyl)-L-threonine" EXACT RESID-name []
synonym: "O3-(isoglutamyl)threonine" EXACT RESID-alternate []
xref: DiffAvg: "none"
xref: DiffFormula: "none"
xref: DiffMono: "none"
xref: Formula: "C 9 H 14 N 2 O 5"
xref: MassAvg: "230.22"
xref: MassMono: "230.090272"
xref: Origin: "T, X"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:00859 ! modified residue that can arise from different natural residues
is_a: MOD:02056 ! crosslinked L-threonine residue

[Term]
id: MOD:01980
name: omega-N-glycosyl-L-arginine
def: "A protein modification that effectively converts an L-arginine residue to N4-glycosyl-arginine." [PubMed:15279557, PubMed:8521968, PubMed:9536051, RESID:AA0327, Unimod:41#R]
synonym: "(2S)-2-amino-5-(beta-D-glucopyranosyl[imino(methylamino)methyl]amino)pentanoic acid" EXACT RESID-systematic []
synonym: "Hex" RELATED PSI-MS-label []
synonym: "Hexose" RELATED Unimod-description []
synonym: "NG-beta-D-glucosylarginine" EXACT RESID-alternate []
synonym: "omega-N-(beta-D-glucosyl)-L-arginine" EXACT RESID-alternate []
synonym: "omega-N-glucosyl-L-arginine" EXACT RESID-name []
synonym: "omega-N-glycosyl-L-arginine" EXACT RESID-alternate []
xref: Origin: "R"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:41"
is_a: MOD:00006 ! N-glycosylated residue
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:01981
name: 3-methyllanthionine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 3-methyllanthionine with unresolved stereospecificity." [PubMed:18688235]
comment: Cross-link 2.
synonym: "2,6-diamino-3-methyl-4-thiaheptanedioic acid" EXACT PSI-MOD-alternate []
synonym: "2-amino-3-([2-amino-2-carboxyethyl]sulfanyl)butanoic acid" EXACT PSI-MOD-alternate []
synonym: "2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid" EXACT PSI-MOD-alternate []
synonym: "2-azanyl-3-[(2-azanyl-2-carboxyethyl)sulfanyl]butanoic acid" EXACT PSI-MOD-alternate []
synonym: "3-methyllanthionine" EXACT PSI-MOD-alternate []
synonym: "cysteine-3-L-butyrine thioether" EXACT PSI-MOD-alternate []
xref: DiffAvg: "-18.02"
xref: DiffFormula: "C 0 H -2 N 0 O -1 S 0"
xref: DiffMono: "-18.010565"
xref: Formula: "C 7 H 10 N 2 O 2 S 1"
xref: MassAvg: "186.23"
xref: MassMono: "186.046299"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:00954 ! crosslinked residues with loss of water
is_a: MOD:01993 ! beta-carbon thioether crosslinked residues

[Term]
id: MOD:01982
name: N,N,N-trimethylglycine
def: "modification from RESID" [ChEBI:17750, PubMed:23818633, PubMed:23978223, RESID:AA0619]
subset: PSI-MOD-slim
synonym: "(trimethylammonio)ethanoic acid" EXACT RESID-alternate []
synonym: "1-carboxy-N,N,N-trimethylmethanazanium" EXACT RESID-alternate []
synonym: "2-trimethylammonioacetate" EXACT RESID-alternate []
synonym: "betaine" EXACT RESID-alternate []
synonym: "carboxy-N,N,N-trimethylmethanaminium" EXACT RESID-systematic []
synonym: "carboxymethyl-trimethylazanium" EXACT RESID-alternate []
synonym: "glycine betaine" EXACT RESID-alternate []
synonym: "MOD_RES N,N,N-trimethylglycine" EXACT UniProt-feature []
synonym: "N,N,N-trimethylglycine cation" EXACT RESID-alternate []
synonym: "N,N,N-trimethylglycinium" EXACT RESID-alternate []
synonym: "N2Me3+Gly" EXACT PSI-MOD-label []
xref: DiffAvg: "43.09"
xref: DiffFormula: "C 3 H 7 N 0 O 0"
xref: DiffMono: "43.054775"
xref: FormalCharge: "1+"
xref: Formula: "C 5 H 11 N 1 O 1"
xref: MassAvg: "101.15"
xref: MassMono: "101.084064"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0485
is_a: MOD:00714 ! methylated glycine
is_a: MOD:01698 ! alpha-amino trimethylated protonated-residue

[Term]
id: MOD:01983
name: N,N-dimethylglycine
def: "A protein modification that effectively converts a glycine residue to N,N-dimethyllglycine." [ChEBI:17724, PubMed:23818633, PubMed:23978223, RESID:AA0620]
synonym: "(dimethylamino)ethanoic acid" EXACT RESID-systematic []
synonym: "1-carboxy-N,N-dimethylaminomethane" EXACT RESID-alternate []
synonym: "2-(dimethylamino)acetic acid" EXACT RESID-alternate []
synonym: "MOD_RES N,N-dimethylglycine" EXACT UniProt-feature []
synonym: "vitamin B16" EXACT RESID-alternate []
xref: DiffAvg: "28.05"
xref: DiffFormula: "C 2 H 4 N 0 O 0"
xref: DiffMono: "28.031300"
xref: Formula: "C 4 H 8 N 1 O 1"
xref: MassAvg: "86.11"
xref: MassMono: "86.060589"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: uniprot.ptm:PTM-0484
is_a: MOD:00714 ! methylated glycine
is_a: MOD:01686 ! alpha-amino dimethylated residue

[Term]
id: MOD:01984
name: 2-(L-cystein-S-yl)-L-alanine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-alanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-alanine." [PubMed:21526839, RESID:AA0621]
comment: Cross-link 2.
synonym: "(2R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid" EXACT RESID-systematic []
synonym: "(2R,5R)-2,5-diamino-5-methyl-4-thiahexanedioic acid" EXACT RESID-alternate []
synonym: "alpha-(L-cystein-S-yl)-L-alanine" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 6 H 8 N 2 O 2 S 1"
xref: MassAvg: "172.20"
xref: MassMono: "172.030649"
xref: Origin: "A, C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02040 ! crosslinked L-alanine residue
is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues

[Term]
id: MOD:01985
name: 2-(L-cystein-S-yl)-D-asparagine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-asparagine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-asparagine." [PubMed:21786372, RESID:AA0622]
comment: Cross-link 2.
synonym: "(2S)-2,4-diamino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-4-oxobutanoic acid" EXACT RESID-systematic []
synonym: "alpha-(L-cystein-S-yl)-D-asparagine" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 7 H 9 N 3 O 3 S 1"
xref: MassAvg: "215.23"
xref: MassMono: "215.036462"
xref: Origin: "C, N"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:02060 ! crosslinked D-asparagine residue
is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues

[Term]
id: MOD:01986
name: 2-(L-cystein-S-yl)-L-serine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-serine." [PubMed:21526839, RESID:AA0623]
comment: Cross-link 2.
synonym: "(2R)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid" EXACT RESID-systematic []
synonym: "(2R,5R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 6 H 8 N 2 O 3 S 1"
xref: MassAvg: "188.20"
xref: MassMono: "188.025563"
xref: Origin: "C, S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02055 ! crosslinked L-serine residue
is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues

[Term]
id: MOD:01987
name: 2-(L-cystein-S-yl)-D-serine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-serine." [PubMed:21786372, RESID:AA0624]
comment: Cross-link 2.
synonym: "(2R,5S)-2,5-diamino-5-carboxy-6-hydroxy-4-thiahexanoic acid" EXACT RESID-alternate []
synonym: "(2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-hydroxypropanoic acid" EXACT RESID-systematic []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 6 H 8 N 2 O 3 S 1"
xref: MassAvg: "188.20"
xref: MassMono: "188.025563"
xref: Origin: "C, S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:02064 ! crosslinked D-serine residue
is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues

[Term]
id: MOD:01988
name: 2-(L-cystein-S-yl)-L-threonine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-threonine." [PubMed:21526839, RESID:AA0625]
comment: Cross-link 2.
synonym: "(2R,3R)-2-amino-2-[(2R)-2-amino-2-carboxyethyl]sulfanyl-3-hydroxybutanoic acid" EXACT RESID-systematic []
synonym: "(2R,5R,6R)-2,5-diamino-5-carboxy-6-hydroxy-4-thiaheptanoic acid" EXACT RESID-alternate []
synonym: "alpha-(L-cystein-S-yl)-L-threonine" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 7 H 10 N 2 O 3 S 1"
xref: MassAvg: "202.23"
xref: MassMono: "202.041213"
xref: Origin: "C, T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02056 ! crosslinked L-threonine residue
is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues

[Term]
id: MOD:01989
name: 2-(L-cystein-S-yl)-D-tyrosine
def: "A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-tyrosine." [PubMed:21526839, RESID:AA0626]
comment: Cross-link 2.
synonym: "(2R,5S)-2,5-diamino-5-carboxyl-6-(hydroxyphenyl)-4-thiahexanoic acid" EXACT RESID-alternate []
synonym: "(2S)-2-amino-2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-3-(4-hydroxyphenyl)propanoic acid" EXACT RESID-systematic []
synonym: "alpha-(L-cystein-S-yl)-D-tyrosine" EXACT RESID-alternate []
xref: DiffAvg: "-2.02"
xref: DiffFormula: "C 0 H -2 N 0 O 0 S 0"
xref: DiffMono: "-2.015650"
xref: Formula: "C 12 H 12 N 2 O 3 S 1"
xref: MassAvg: "264.30"
xref: MassMono: "264.056863"
xref: Origin: "C, Y"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00664 ! stereoisomerized residue
is_a: MOD:02058 ! crosslinked L-tyrosine residue
is_a: MOD:01992 ! alpha-carbon thioether crosslinked residues

[Term]
id: MOD:01990
name: protonated glycine (glycinium) residue
def: "A protein modification that effectively converts a glycine residue to a glycinium (protonated glycine)." [ChEBI:64723, PubMed:18688235]
subset: PSI-MOD-slim
xref: DiffAvg: "1.01"
xref: DiffFormula: "C 0 H 1 N 0 O 0"
xref: DiffMono: "1.007276"
xref: FormalCharge: "1+"
xref: Formula: "C 2 H 5 N 1 O 1"
xref: MassAvg: "59.07"
xref: MassMono: "59.036565"
xref: Origin: "G"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:00908 ! modified glycine residue
is_a: MOD:01700 ! alpha-amino protonated residue

[Term]
id: MOD:01991
name: N,N,N-trimethylglycine (from glycinium)
def: "A protein modification that effectively converts a glycinium (protonated glycine) residue to an N,N,N-trimethylglycine." [ChEBI:17750, PubMed:23818633, PubMed:23978223, RESID:AA0619]
comment: For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Gly process (MOD:01982) accounts for both protonation and trimethylation.
subset: PSI-MOD-slim
synonym: "N2Me3Gly" EXACT PSI-MOD-label []
xref: DiffAvg: "42.08"
xref: DiffFormula: "C 3 H 6 N 0 O 0"
xref: DiffMono: "42.046402"
xref: FormalCharge: "1+"
xref: Formula: "C 5 H 11 N 1 O 1"
xref: MassAvg: "101.15"
xref: MassMono: "101.083515"
xref: Origin: "MOD:01990"
xref: Source: "natural"
xref: TermSpec: "N-term"
is_a: MOD:01687 ! alpha-amino trimethylated residue
relationship: derives_from MOD:01990 ! protonated glycine (glycinium) residue

[Term]
id: MOD:01992
name: alpha-carbon thioether crosslinked residues
def: "A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the alpha-carbon of another amino acid residue." [PubMed:18688235]
is_a: MOD:00687 ! thioether crosslinked residues

[Term]
id: MOD:01993
name: beta-carbon thioether crosslinked residues
def: "A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and the beta-carbon of another amino acid residue." [PubMed:18688235]
comment: These are typical lanthionine-like crosslinks.
is_a: MOD:00687 ! thioether crosslinked residues

[Term]
id: MOD:01994
name: N1'-formyl-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to N1'-formyl-L-tryptophan." [PubMed:18688235]
comment: This modifications has not been reported as commonly encountered [JSG].
synonym: "N1'FoTrp" EXACT PSI-MOD-label []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 H 0 N 0 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "C 12 H 10 N 2 O 2"
xref: MassAvg: "214.22"
xref: MassMono: "214.074228"
xref: Origin: "W"
xref: Source: "hypothetical"
xref: TermSpec: "none"
is_a: MOD:01106 ! N-formyl-L-tryptophan

[Term]
id: MOD:01995
name: N2-formyl-L-tryptophan
def: "A protein modification that effectively converts an L-tryptophan residue to N2-formyl-L-tryptophan." [PubMed:18688235]
comment: This modifications has not been reported as commonly encountered [JSG].
synonym: "N2FoTrp" EXACT PSI-MOD-label []
xref: DiffAvg: "28.01"
xref: DiffFormula: "C 1 H 0 N 0 O 1"
xref: DiffMono: "27.994915"
xref: Formula: "C 12 H 11 N 2 O 2"
xref: MassAvg: "215.23"
xref: MassMono: "215.082053"
xref: Origin: "W"
xref: Source: "hypothetical"
xref: TermSpec: "N-term"
is_a: MOD:01106 ! N-formyl-L-tryptophan

[Term]
id: MOD:01996
name: butanoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an butanoyl group." [PubMed:18688235]
comment: Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters).
synonym: "ButRes" EXACT PSI-MOD-label []
synonym: "Butyryl" RELATED Unimod-interim []
synonym: "butyrylation" EXACT PSI-MOD-alternate []
xref: DiffAvg: "70.09"
xref: DiffFormula: "C 4 H 6 O 1"
xref: DiffMono: "70.041865"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue

[Term]
id: MOD:01997
name: N-butanoylated residue
def: "A protein modification that effectively replaces a residue amino or imino hydrogen with a butanoyl group." [PubMed:18688235]
synonym: "N-butanoyl" EXACT PSI-MOD-alternate []
synonym: "N-butanoylation" EXACT PSI-MOD-alternate []
synonym: "N-butyryl" EXACT PSI-MOD-alternate []
synonym: "N-butyrylation" EXACT PSI-MOD-alternate []
synonym: "NButRes" EXACT PSI-MOD-label []
xref: DiffAvg: "70.09"
xref: DiffFormula: "C 4 H 6 N 0 O 1"
xref: DiffMono: "70.041865"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:01996 ! butanoylated residue

[Term]
id: MOD:01998
name: alpha-amino butanoylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a butanoyl group." [PubMed:18688235]
synonym: "N2ButRes" EXACT PSI-MOD-label []
xref: DiffAvg: "70.09"
xref: DiffFormula: "C 4 H 6 N 0 O 1"
xref: DiffMono: "70.041865"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "N-term"
is_a: MOD:01997 ! N-butanoylated residue

[Term]
id: MOD:01999
name: N6-(11-cis)-retinylidene-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-retinylidene-(11-cis)-L-lysine." [PubMed:18688235]
synonym: "(2S)-2-amino-6-[(2E,4Z,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT PSI-MOD-alternate []
xref: DiffAvg: "266.43"
xref: DiffFormula: "C 20 H 26 N 0 O 0"
xref: DiffMono: "266.203451"
xref: Formula: "C 26 H 38 N 2 O 1"
xref: MassAvg: "394.60"
xref: MassMono: "394.298414"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02000 ! N6-retinylidene-L-lysine (unspecified geometric isomer)

[Term]
id: MOD:02000
name: N6-retinylidene-L-lysine (unspecified geometric isomer)
def: "A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine (unspecified geometric isomer)." [PubMed:18688235]
synonym: "(2S)-2-amino-6-[3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)-2,4,6,8-nonatetraenylidene]aminohexanoic acid" EXACT PSI-MOD-alternate []
xref: DiffAvg: "266.43"
xref: DiffFormula: "C 20 H 26 N 0 O 0"
xref: DiffMono: "266.203451"
xref: Formula: "C 26 H 38 N 2 O 1"
xref: MassAvg: "394.60"
xref: MassMono: "394.298414"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:02001
name: stearoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a stearoyl group." []
subset: PSI-MOD-slim
xref: DiffAvg: "266.47"
xref: DiffFormula: "C 18 H 34 O 1"
xref: DiffMono: "266.260966"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:02002
name: S-palmitoleylated residue
def: "A protein modification that effectively replaces a residue sulfanyl group with a palmitoleylsulfanyl group." []
subset: PSI-MOD-slim
xref: DiffAvg: "236.40"
xref: DiffFormula: "C 16 H 28 N 0 O 1"
xref: DiffMono: "236.214016"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00672 ! S-acylated residue
is_a: MOD:01423 ! palmitoleylated residue

[Term]
id: MOD:02003
name: O3-acylated L-serine
def: "A protein modification that effectively replaces an O3-hydroxy hydrogen atom of L-serine with an acyl group." []
subset: PSI-MOD-slim
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00671 ! O-acylated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:02004
name: O3-acylated L-threonine
def: "A protein modification that effectively replaces an O3-hydroxy hydrogen atom of L-threonine with an acyl group." []
subset: PSI-MOD-slim
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00671 ! O-acylated residue
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:02005
name: S-acylated L-cysteine
def: "A protein modification that effectively replaces an sulfanyl hydrogen atom of L-cysteine with an acyl group." []
subset: PSI-MOD-slim
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00672 ! S-acylated residue
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:02006
name: S-stearoylated residue
def: "A protein modification that effectively replaces a residue sulfanyl group with a stearoylsulfanyl group." []
subset: PSI-MOD-slim
xref: DiffAvg: "266.47"
xref: DiffFormula: "C 18 H 34 O 1"
xref: DiffMono: "266.260966"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00672 ! S-acylated residue
is_a: MOD:02001 ! stearoylated residue

[Term]
id: MOD:02007
name: N6-palmitoleyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-palmitoleyl-L-lysine." []
subset: PSI-MOD-slim
xref: DiffAvg: "236.40"
xref: DiffFormula: "C 16 H 28 N 0 O 1"
xref: DiffMono: "236.214016"
xref: Formula: "C 22 H 40 N 2 O 2"
xref: MassAvg: "364.58"
xref: MassMono: "364.308979"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01875 ! N6-acylated L-lysine
is_a: MOD:02008 ! N-palmitoleylated residue

[Term]
id: MOD:02008
name: N-palmitoleylated residue
def: "A protein modification that effectively replaces a residue amino group with a palmitoleylamino group." []
subset: PSI-MOD-slim
xref: DiffAvg: "236.40"
xref: DiffFormula: "C 16 H 28 N 0 O 1"
xref: DiffMono: "236.214016"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00670 ! N-acylated residue
is_a: MOD:01423 ! palmitoleylated residue

[Term]
id: MOD:02009
name: N6-stearoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-stearoyl-L-lysine." []
subset: PSI-MOD-slim
xref: DiffAvg: "266.47"
xref: DiffFormula: "C 18 H 34 O 1"
xref: DiffMono: "266.260966"
xref: Formula: "C 24 H 46 N 2 O 2"
xref: MassAvg: "394.65"
xref: MassMono: "394.355929"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01875 ! N6-acylated L-lysine
is_a: MOD:02010 ! N-stearoylated residue

[Term]
id: MOD:02010
name: N-stearoylated residue
def: "A protein modification that effectively replaces a residue amino group with a stearoylamino group." []
subset: PSI-MOD-slim
xref: DiffAvg: "266.47"
xref: DiffFormula: "C 18 H 34 O 1"
xref: DiffMono: "266.260966"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00670 ! N-acylated residue
is_a: MOD:02001 ! stearoylated residue

[Term]
id: MOD:02011
name: N-oleoylated residue
def: "A protein modification that effectively replaces a residue amino group with a oleoylamino group." []
subset: PSI-MOD-slim
xref: DiffAvg: "264.45"
xref: DiffFormula: "C 18 H 32 N 0 O 1"
xref: DiffMono: "264.245316"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00670 ! N-acylated residue
is_a: MOD:02012 ! oleoylated residue

[Term]
id: MOD:02012
name: oleoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a oleoyl group." []
subset: PSI-MOD-slim
xref: DiffAvg: "264.45"
xref: DiffFormula: "C 18 H 32 N 0 O 1"
xref: DiffMono: "264.245316"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:02013
name: N6-linoloyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-linoloyl-L-lysine." []
subset: PSI-MOD-slim
xref: DiffAvg: "262.45"
xref: DiffFormula: "C 18 H 30 N 0 O 1"
xref: DiffMono: "262.229666"
xref: Formula: "C 24 H 42 N 2 O 2"
xref: MassAvg: "390.63"
xref: MassMono: "390.324629"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01875 ! N6-acylated L-lysine
is_a: MOD:02014 ! N-linoloylated residue

[Term]
id: MOD:02014
name: N-linoloylated residue
def: "A protein modification that effectively replaces a residue amino group with a linoloylamino group." []
subset: PSI-MOD-slim
xref: DiffAvg: "262.45"
xref: DiffFormula: "C 18 H 30 N 0 O 1"
xref: DiffMono: "262.229666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00670 ! N-acylated residue
is_a: MOD:02015 ! linoloylated residue

[Term]
id: MOD:02015
name: linoloylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a linoloyl group." []
subset: PSI-MOD-slim
xref: DiffAvg: "262.45"
xref: DiffFormula: "C 18 H 30 N 0 O 1"
xref: DiffMono: "262.229666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:02016
name: N6-arachidonoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-arachidonoyl-L-lysine." []
subset: PSI-MOD-slim
xref: DiffAvg: "286.49"
xref: DiffFormula: "C 20 H 30 N 0 O 1"
xref: DiffMono: "286.229666"
xref: Formula: "C 26 H 42 N 2 O 2"
xref: MassAvg: "414.67"
xref: MassMono: "414.324629"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01875 ! N6-acylated L-lysine
is_a: MOD:02017 ! N-arachidonoylated residue

[Term]
id: MOD:02017
name: N-arachidonoylated residue
def: "A protein modification that effectively replaces a residue amino group with an arachidonoylamino group." []
subset: PSI-MOD-slim
xref: DiffAvg: "286.49"
xref: DiffFormula: "C 20 H 30 N 0 O 1"
xref: DiffMono: "286.229666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00670 ! N-acylated residue
is_a: MOD:02018 ! arachidonoylated residue

[Term]
id: MOD:02018
name: arachidonoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an arachidonoyl group." []
subset: PSI-MOD-slim
xref: DiffAvg: "286.49"
xref: DiffFormula: "C 20 H 30 N 0 O 1"
xref: DiffMono: "286.229666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:02019
name: N6-timnodonoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-timnodonoyl-L-lysine." []
subset: PSI-MOD-slim
xref: DiffAvg: "284.48"
xref: DiffFormula: "C 20 H 28 N 0 O 1"
xref: DiffMono: "284.214016"
xref: Formula: "C 26 H 40 N 2 O 2"
xref: MassAvg: "412.66"
xref: MassMono: "412.308979"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01875 ! N6-acylated L-lysine
is_a: MOD:02020 ! N-timnodonoylated residue

[Term]
id: MOD:02020
name: N-timnodonoylated residue
def: "A protein modification that effectively replaces a residue amino group with a timnodonoylamino group." []
subset: PSI-MOD-slim
xref: DiffAvg: "284.48"
xref: DiffFormula: "C 20 H 28 N 0 O 1"
xref: DiffMono: "284.214016"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00670 ! N-acylated residue
is_a: MOD:02021 ! timnodonoylated residue

[Term]
id: MOD:02021
name: timnodonoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a timnodonoyl group." []
subset: PSI-MOD-slim
xref: DiffAvg: "284.48"
xref: DiffFormula: "C 20 H 28 N 0 O 1"
xref: DiffMono: "284.214016"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:02022
name: N6-cervonoyl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-cervonoyl-L-lysine." []
subset: PSI-MOD-slim
xref: DiffAvg: "310.53"
xref: DiffFormula: "C 22 H 30 N 0 O 1"
xref: DiffMono: "310.229666"
xref: Formula: "C 28 H 42 N 2 O 2"
xref: MassAvg: "438.71"
xref: MassMono: "438.324629"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:01875 ! N6-acylated L-lysine
is_a: MOD:02023 ! N-cervonoylated residue

[Term]
id: MOD:02023
name: N-cervonoylated residue
def: "A protein modification that effectively replaces a residue amino group with a cervonoylamino group." []
subset: PSI-MOD-slim
xref: DiffAvg: "310.53"
xref: DiffFormula: "C 22 H 30 N 0 O 1"
xref: DiffMono: "310.229666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00670 ! N-acylated residue
is_a: MOD:02024 ! cervonoylated residue

[Term]
id: MOD:02024
name: cervonoylated residue
def: "A protein modification that effectively replaces a hydrogen atom with a cervonoyl group." []
subset: PSI-MOD-slim
xref: DiffAvg: "310.53"
xref: DiffFormula: "C 22 H 30 N 0 O 1"
xref: DiffMono: "310.229666"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue
is_a: MOD:01155 ! lipoconjugated residue

[Term]
id: MOD:02025
name: 5-glutaminyl glutamic acid
def: "A protein modification that effectively converts the alpha amino group of a glutamine residue to glutaminyl glutamic acid by forming an isopeptide bond with the side chain carboxyl group of a free glutamic acid." [PubMed:28801462]
xref: DiffAvg: "128.13"
xref: DiffFormula: "C 5 H 8 N 2 O 2"
xref: DiffMono: "128.058576"
xref: Formula: "C 10 H 15 N 3 O 5"
xref: MassAvg: "257.24"
xref: MassMono: "257.101167"
xref: Origin: "E"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:02026
name: S-(cysteinyl-glycyl)-L-cysteine
def: "A protein modification that effectively cross-links an L-cysteinyl-L-glycine dipeptide and an L-cysteine residue by a disulfide bond to form S-(cysteinyl-glycyl)-L-cysteine." [PubMed:27936627, PubMed:20594348, PubMed:29627744]
comment: Glutamyl-transpeptidase cleaves glutathione into cysteinylglycine (Cys-Gly) and a Glu residue. [PubMed:28537416]
xref: DiffAvg: "176.17"
xref: DiffFormula: "C 5 H 8 N 2 O 3 S 1"
xref: DiffMono: "176.025563"
xref: Formula: "C 8 H 13 N 3 O 4 S 2"
xref: MassAvg: "279.33"
xref: MassMono: "279.034748"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:01862 ! disulfide conjugated residue
relationship: part_of MOD:00234 ! L-cysteine glutathione disulfide

[Term]
id: MOD:02027
name: urmylated lysine
def: "A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a URM1 protein." [PubMed:10713047, PubMed:21209336]
subset: PSI-MOD-slim
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:02047 ! crosslinked glycine residue
is_a: MOD:02051 ! crosslinked L-lysine residue
is_a: MOD:01875 ! N6-acylated L-lysine
relationship: contains MOD:00134 ! N6-glycyl-L-lysine

[Term]
id: MOD:02028
name: iTRAQ4plex reporter+balance reagent acylated residue, average mass modification
def: "A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups." [Unimod:214]
comment: The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification. Four versions of chemically identical iTRAQ4plex moyeties, but with different isotope distribution. This modification is calculated as the average of the four species. It has no isotopic distribution reality, the exact mass does not correspond to any real isotopic distribution.
subset: PSI-MOD-slim
synonym: "(4-methylpiperazin-1-yl)acetyl" EXACT PSI-MOD-alternate []
synonym: "iTRAQ" RELATED Unimod-interim []
xref: DiffAvg: "144.10"
xref: DiffFormula: "none"
xref: DiffMono: "144.102411"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:01426 ! isotope tagged reagent derivatized residue
is_a: MOD:01705 ! isotope tagged reagent acylated residue
is_a: MOD:01709 ! iTRAQ4plex reporter+balance reagent N-acylated residue
is_a: MOD:01513 ! modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.1 Da

[Term]
id: MOD:02029
name: cis-peptidyl-L-proline
def: "A protein modification that effectively specifies the boundary conformation of two adjacent source amino acid residues, the second (C-term side) being a L-proline, where the carbonyl group of the amide bond of the N-side of the L-proline is positioned such that the organodiyl group is in the cis orientation (omega=0)" [ChEBI:83833, PubMed:15735342, PubMed:15311922, PubMed:24116866, PubMed:5485910]
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Origin: "X, P"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:02030
name: trans-peptidyl-L-proline
def: "A protein modification that effectively specifies the boundary conformation of two adjacent source amino acid residues, the second (C-term side) being a L-proline, where the carbonyl group of the amide bond of the N-side of the L-proline is positioned such that the organodiyl group is in the trans orientation (omega=180)" [ChEBI:83834, PubMed:15735342, PubMed:15311922, PubMed:24116866, PubMed:5485910]
xref: DiffAvg: "0.00"
xref: DiffFormula: "C 0 H 0 N 0 O 0"
xref: DiffMono: "0.000000"
xref: Origin: "X, P"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:02031
name: dHex1Hex4HexNAc5 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, dHex Hex(4) HexNAc(5)" [PubMed:33135055, Unimod:1519]
synonym: "dHex Hex(4) HexNAc(5)" RELATED Unimod-description []
xref: DiffAvg: "1810.68"
xref: DiffFormula: "C 70 H 115 N 5 O 49"
xref: DiffMono: "1809.666065"
xref: Formula: "C 74 H 121 N 7 O 51"
xref: MassAvg: "1924.78"
xref: MassMono: "1923.708993"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1519"
xref: GNOme: "GNO:G03382KH"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:02032
name: dHex2Hex4HexNAc5 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, dHex(2) Hex(4) HexNAc(5)" [PubMed:33135055, Unimod:1785]
synonym: "dHex(2) Hex(4) HexNAc(5)" RELATED Unimod-description []
xref: DiffAvg: "1956.82"
xref: DiffFormula: "C 76 H 125 N 5 O 53"
xref: DiffMono: "1955.723974"
xref: Formula: "C 80 H 131 N 7 O 55"
xref: MassAvg: "2070.92"
xref: MassMono: "2069.766901"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1785"
xref: GNOme: "GNO:G70418MS"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:02033
name: dHex1Hex5HexNAc3 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, dHex Hex(5) HexNAc(3)" [PubMed:33135055, Unimod:1484]
synonym: "dHex Hex(5) HexNAc(3)" RELATED Unimod-description []
xref: DiffAvg: "1566.43"
xref: DiffFormula: "C 60 H 99 N 3 O 44"
xref: DiffMono: "1565.560143"
xref: Formula: "C 64 H 105 N 5 O 46"
xref: MassAvg: "1680.53"
xref: MassMono: "1679.603071"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1484"
xref: GNOme: "GNO:G82119TF"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:02034
name: dHex1Hex3HexNAc6 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, dHex Hex(3) HexNAc(6)" [PubMed:33135055, Unimod:1781]
synonym: "dHex Hex(3) HexNAc(6)" RELATED Unimod-description []
xref: DiffAvg: "1851.73"
xref: DiffFormula: "C 72 H 118 N 6 O 49"
xref: DiffMono: "1850.692614"
xref: Formula: "C 76 H 124 N 8 O 51"
xref: MassAvg: "1965.83"
xref: MassMono: "1964.735542"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1781"
xref: GNOme: "GNO:G50757KG"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:02035
name: dHex1Hex6HexNAc3 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, dHex Hex(6) HexNAc(3)" [PubMed:33135055, Unimod:1509]
synonym: "dHex Hex(6) HexNAc(3)" RELATED Unimod-description []
xref: DiffAvg: "1728.57"
xref: DiffFormula: "C 66 H 109 N 3 O 49"
xref: DiffMono: "1727.612967"
xref: Formula: "C 70 H 115 N 5 O 51"
xref: MassAvg: "1842.67"
xref: MassMono: "1841.655894"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1509"
xref: GNOme: "GNO:G84820NF"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:02036
name: Hex9HexNAc2 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, Hex(9)HexNAc(2)" [PubMed:33135055, Unimod:1531]
synonym: "M9/Man9" RELATED Unimod-description []
xref: DiffAvg: "1865.66"
xref: DiffFormula: "C 70 H 116 N 2 O 55"
xref: DiffMono: "1864.634156"
xref: Formula: "C 74 H 122 N 4 O 57"
xref: MassAvg: "1979.76"
xref: MassMono: "1978.677083"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1531"
xref: GNOme: "GNO:G70101JE"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:02037
name: Hex7HexNAc2 N4-glycosylated asparagine
def: "modification from Unimod N-linked glycosylation, Hex(7) HexNAc(2)" [PubMed:33135055, Unimod:1480]
synonym: "M7/Man7" RELATED Unimod-description []
xref: DiffAvg: "1541.38"
xref: DiffFormula: "C 58 H 96 N 2 O 45"
xref: DiffMono: "1540.528509"
xref: Formula: "C 62 H 102 N 4 O 47"
xref: MassAvg: "1655.48"
xref: MassMono: "1654.571436"
xref: MassMono: "1654.571436"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1480"
xref: GNOme: "GNO:G05724UK"
is_a: MOD:00725 ! complex glycosylation
is_a: MOD:00160 ! N4-glycosyl-L-asparagine

[Term]
id: MOD:02038
name: monomethylated L-histidine
def: "A protein modification that effectively replaces one hydrogen atom of an L-histidine residue with one methyl group." [DeltaMass:215, OMSSA:77, Unimod:34#H]
subset: PSI-MOD-slim
synonym: "Me1His" EXACT PSI-MOD-label []
synonym: "Methyl" RELATED PSI-MS-label []
synonym: "methylh" EXACT OMSSA-label []
synonym: "MOD_RES Methylhistidine" EXACT UniProt-feature []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 7 H 9 N 3 O 1"
xref: MassAvg: "151.17"
xref: MassMono: "151.074562"
xref: Origin: "H"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:34"
xref: uniprot.ptm:PTM-0176
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00661 ! methylated histidine

[Term]
id: MOD:02039
name: aminated residue
def: "A protein modification that effectively replaces a hydrogen group with a amino group" []
synonym: "AmRes" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:02040
name: crosslinked L-alanine residue
def: "A protein modification that contains an L-alanine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkAla" EXACT PSI-MOD-label []
xref: Origin: "A"
is_a: MOD:00901 ! modified L-alanine residue

[Term]
id: MOD:02041
name: crosslinked L-arginine residue
def: "A protein modification that contains an L-arginine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkArg" EXACT PSI-MOD-label []
xref: Origin: "R"
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:02042
name: crosslinked L-asparagine residue
def: "A protein modification that contains an L-asparagine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkAsn" EXACT PSI-MOD-label []
xref: Origin: "N"
is_a: MOD:00903 ! modified L-asparagine residue

[Term]
id: MOD:02043
name: crosslinked L-aspartic acid residue
def: "A protein modification that contains an L-aspartic acid residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkAsp" EXACT PSI-MOD-label []
xref: Origin: "D"
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:02044
name: crosslinked L-cysteine residue
def: "A protein modification that contains an L-cysteine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkCys" EXACT PSI-MOD-label []
xref: Origin: "C"
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:02045
name: crosslinked L-glutamic acid residue
def: "A protein modification that contains an L-glutamic acid residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkGlu" EXACT PSI-MOD-label []
xref: Origin: "E"
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:02046
name: crosslinked L-glutamine residue
def: "A protein modification that contains an L-glutamine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkGln" EXACT PSI-MOD-label []
xref: Origin: "Q"
is_a: MOD:00907 ! modified L-glutamine residue

[Term]
id: MOD:02047
name: crosslinked glycine residue
def: "A protein modification that contains a glycine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkGly" EXACT PSI-MOD-label []
xref: Origin: "G"
is_a: MOD:00908 ! modified glycine residue

[Term]
id: MOD:02048
name: crosslinked L-histidine residue
def: "A protein modification that contains an L-histidine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkHis" EXACT PSI-MOD-label []
xref: Origin: "H"
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:02049
name: crosslinked L-isoleucine residue
def: "A protein modification that contains an L-isoleucine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkIle" EXACT PSI-MOD-label []
xref: Origin: "I"
is_a: MOD:00910 ! modified L-isoleucine residue

[Term]
id: MOD:02050
name: crosslinked L-leucine residue
def: "A protein modification that contains an L-leucine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkLeu" EXACT PSI-MOD-label []
xref: Origin: "L"
is_a: MOD:00911 ! modified L-leucine residue

[Term]
id: MOD:02051
name: crosslinked L-lysine residue
def: "A protein modification that contains an L-lysine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkLys" EXACT PSI-MOD-label []
xref: Origin: "K"
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:02052
name: crosslinked L-methionine residue
def: "A protein modification that contains an L-methionine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkMet" EXACT PSI-MOD-label []
xref: Origin: "M"
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:02053
name: crosslinked L-phenylalanine residue
def: "A protein modification that contains an L-phenylalanine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkPhe" EXACT PSI-MOD-label []
xref: Origin: "F"
is_a: MOD:00914 ! modified L-phenylalanine residue

[Term]
id: MOD:02054
name: crosslinked L-proline residue
def: "A protein modification that contains an L-proline residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkPro" EXACT PSI-MOD-label []
xref: Origin: "P"
is_a: MOD:00915 ! modified L-proline residue

[Term]
id: MOD:02055
name: crosslinked L-serine residue
def: "A protein modification that contains an L-serine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkSer" EXACT PSI-MOD-label []
xref: Origin: "S"
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:02056
name: crosslinked L-threonine residue
def: "A protein modification that contains an L-threonine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkThr" EXACT PSI-MOD-label []
xref: Origin: "T"
is_a: MOD:00917 ! modified L-threonine residue

[Term]
id: MOD:02057
name: crosslinked L-tryptophan residue
def: "A protein modification that contains an L-tryptophan residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkTrp" EXACT PSI-MOD-label []
xref: Origin: "W"
is_a: MOD:00918 ! modified L-tryptophan residue

[Term]
id: MOD:02058
name: crosslinked L-tyrosine residue
def: "A protein modification that contains an L-tyrosine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkTyr" EXACT PSI-MOD-label []
xref: Origin: "Y"
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:02059
name: crosslinked L-valine residue
def: "A protein modification that contains an L-valine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkVal" EXACT PSI-MOD-label []
xref: Origin: "V"
is_a: MOD:00920 ! modified L-valine residue

[Term]
id: MOD:02060
name: crosslinked D-asparagine residue
def: "A protein modification that contains an D-asparagine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkDAsn" EXACT PSI-MOD-label []
xref: Origin: "MOD:00203"
is_a: MOD:02097 ! modified D-asparagine residue

[Term]
id: MOD:02061
name: crosslinked L-selenocysteine residue
def: "A protein modification that contains an L-selenocysteine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "U"
is_a: MOD:01158 ! modified L-selenocysteine residue

[Term]
id: MOD:02062
name: crosslinked N-formyl-L-methionine residue
def: "A protein modification that contains an N-formyl-L-methionine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "MOD:00030"
is_a: MOD:01450 ! modified N-formyl-L-methionine residue

[Term]
id: MOD:02063
name: crosslinked D-phenylalanine residue
def: "A protein modification that contains an D-phenylalanine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkDPhe" EXACT PSI-MOD-label []
xref: Origin: "F"
is_a: MOD:00201 ! D-phenylalanine

[Term]
id: MOD:02064
name: crosslinked D-serine residue
def: "A protein modification that contains an D-serine residue crosslinked to one or more amino acid residues." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "XlnkDSer" EXACT PSI-MOD-label []
xref: Origin: "S"
is_a: MOD:00202 ! D-serine (Ser)

[Term]
id: MOD:02065
name: metal or metal cluster coordinated L-alanine residue
def: "A protein modification that contains an L-alanine residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "A"
is_a: MOD:00901 ! modified L-alanine residue

[Term]
id: MOD:02066
name: metal or metal cluster coordinated L-aspartic acid residue
def: "A protein modification that contains an L-aspartic acid residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "D"
is_a: MOD:00904 ! modified L-aspartic acid residue

[Term]
id: MOD:02067
name: metal or metal cluster coordinated L-cysteine residue
def: "A protein modification that contains an L-cysteine residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "C"
is_a: MOD:00905 ! modified L-cysteine residue

[Term]
id: MOD:02068
name: metal or metal cluster coordinated L-glutamic acid residue
def: "A protein modification that contains an L-glutamic acid residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "E"
is_a: MOD:00906 ! modified L-glutamic acid residue

[Term]
id: MOD:02069
name: metal or metal cluster coordinated L-glutamine residue
def: "A protein modification that contains an L-glutamine residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "Q"
is_a: MOD:00907 ! modified L-glutamine residue

[Term]
id: MOD:02070
name: metal or metal cluster coordinated L-histidine residue
def: "A protein modification that contains an L-histidine residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "H"
is_a: MOD:00909 ! modified L-histidine residue

[Term]
id: MOD:02071
name: metal or metal cluster coordinated L-methionine residue
def: "A protein modification that contains an L-methionine residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "M"
is_a: MOD:00913 ! modified L-methionine residue

[Term]
id: MOD:02072
name: metal or metal cluster coordinated L-serine residue
def: "A protein modification that contains an L-serine residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "S"
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:02073
name: metal or metal cluster coordinated L-selenocysteine residue
def: "A protein modification that contains an L-selenocysteine residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "U"
is_a: MOD:01158 ! modified L-selenocysteine residue

[Term]
id: MOD:02074
name: metal or metal cluster coordinated L-lysine residue
def: "A protein modification that contains an L-lysine residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "K"
is_a: MOD:00912 ! modified L-lysine residue

[Term]
id: MOD:02075
name: metal or metal cluster coordinated L-tyrosine residue
def: "A protein modification that contains an L-tyrosine residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "Y"
is_a: MOD:00919 ! modified L-tyrosine residue

[Term]
id: MOD:02076
name: metal or metal cluster coordinated L-arginine residue
def: "A protein modification that contains an L-arginine residue coordinated to one or more metal atoms or metal clusters." [PubMed:18688235]
subset: PSI-MOD-slim
xref: Origin: "R"
is_a: MOD:00902 ! modified L-arginine residue

[Term]
id: MOD:02077
name: nitrosylated residue
def: "A protein modification that effectively replaces a hydrogen atom with an nitrosyl (NO) group." [PubMed:10442087, PubMed:11562475, PubMed:15688001, PubMed:8626764, PubMed:8637569, Unimod:275]
subset: PSI-MOD-slim
synonym: "Nitrosyl" RELATED PSI-MS-label []
xref: DiffAvg: "29.00"
xref: DiffFormula: "C 0 H -1 N 1 O 1 S 0"
xref: DiffMono: "28.990164"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:275"
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:02078
name: acetylated residue
def: "A protein modification that effectively replaces one or more hydrogen atoms with one or more acetyl groups." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136]
subset: PSI-MOD-slim
synonym: "Acetyl" RELATED PSI-MS-label []
synonym: "AcRes" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:00649 ! acylated residue

[Term]
id: MOD:02079
name: diacetylated residue
def: "A protein modification that effectively replaces one hydrogen atom with one acetyl group." [PubMed:11857757, PubMed:11999733, PubMed:12175151, PubMed:14730666, PubMed:15350136, Unimod:1]
comment: Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). From DeltaMass: Average Mass: 42
subset: PSI-MOD-slim
synonym: "Diacetyl" RELATED PSI-MS-label []
synonym: "Ac2Res" EXACT PSI-MOD-label []
xref: DiffAvg: "84.07"
xref: DiffFormula: "C 4 H 4 N 0 O 2"
xref: DiffMono: "84.021129"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "artifact"
xref: TermSpec: "none"
is_a: MOD:02078 ! acetylated residue

[Term]
id: MOD:02080
name: diacetylated L-serine
def: "A protein modification that effectively converts an L-serine residue to either N-acetyl-L-serine, O-acetyl-L-serine, or N,O-diacetyl-L-serine." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "Ac2Ser" EXACT PSI-MOD-label []
xref: DiffAvg: "84.07"
xref: DiffFormula: "C 4 H 4 N 0 O 2"
xref: DiffMono: "84.021129"
xref: Formula: "C 7 H 10 N 1 O 4"
xref: MassAvg: "172.16"
xref: MassMono: "172.060983"
xref: Origin: "S"
xref: Source: "natural"
is_a: MOD:02079 ! diacetylated residue
is_a: MOD:00916 ! modified L-serine residue

[Term]
id: MOD:02081
name: alpha-amino succinylated residue
def: "A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a succinyl group." [PubMed:11857757, PubMed:12175151, Unimod:64#N-term]
synonym: "Succinyl" RELATED PSI-MS-label []
xref: DiffAvg: "100.07"
xref: DiffFormula: "C 4 H 4 O 3"
xref: DiffMono: "100.016044"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "N-term"
xref: Unimod: "Unimod:64"
is_a: MOD:01029 ! succinylated residue
is_a: MOD:01696 ! alpha-amino acylated residue
is_a: MOD:01426 ! isotope tagged reagent derivatized residue

[Term]
id: MOD:02082
name: didehydrogenated and dehydrated residue
def: "A protein modification that effectively removes two neutral hydrogen atoms (proton and electron) and a water moiety from a residue." [Unimod:401]
subset: PSI-MOD-slim
synonym: "2dHdH2ORes" EXACT PSI-MOD-label []
xref: DiffAvg: "-20.03"
xref: DiffFormula: "C 0 H -4 N 0 O -1"
xref: DiffMono: "-20.026215"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00683 ! dehydrogenated residue

[Term]
id: MOD:02083
name: 4alpha-FMN modified residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through the 4-alpha position of FMN." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "4aFMNRes" EXACT PSI-MOD-label []
xref: DiffFormula: "C 17 H 21 N 4 O 9 P 1"
xref: DiffAvg: "456.35"
xref: DiffMono: "456.104615"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00896 ! FMN modified residue

[Term]
id: MOD:02084
name: 6-FMN modified residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through the 6 position of FMN." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "6-FMNRes" EXACT PSI-MOD-label []
xref: DiffAvg: "454.33"
xref: DiffFormula: "C 17 H 19 N 4 O 9 P 1"
xref: DiffMono: "454.088965"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00896 ! FMN modified residue

[Term]
id: MOD:02085
name: 8alpha-FMN modified residue
def: "A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through the 8-alpha position of FMN." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "8a-FMNRes" EXACT PSI-MOD-label []
xref: DiffAvg: "454.33"
xref: DiffFormula: "C 17 H 19 N 4 O 9 P 1"
xref: DiffMono: "454.088965"
xref: Formula: "none"
xref: MassAvg: "none"
xref: MassMono: "none"
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00896 ! FMN modified residue

[Term]
id: MOD:02086
name: brominated phenylalanine
def: "A protein modification that effectively substitutes a hydrogen atom of an L-phenylalanine residue with a bromine atom." [PubMed:18688235]
synonym: "BrPhe" EXACT PSI-MOD-label []
xref: Origin: "F"
xref: Source: "none"
xref: TermSpec: "none"
is_a: MOD:00754 ! brominated residue
is_a: MOD:01066 ! halogenated phenylalanine

[Term]
id: MOD:02087
name: adenosine diphosphoribosyl (ADP-ribosyl) modified residue
def: "A protein modification that effectively results from forming an adduct with one or more ADP-ribose moieties or to modified residues through formation of a glycosidic bond." [DeltaMass:0]
subset: PSI-MOD-slim
synonym: "ADPRibRes" EXACT PSI-MOD-label []
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00701 ! nucleotide or nucleic acid modified residue

[Term]
id: MOD:02088
name: natural, standard, encoded residue substitution
def: "A protein modification that effectively replaces a natural, standard, encoded residue." [PubMed:18688235]
comment: This represents the replacement of an encoded residue in a polypeptide, and must be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.
subset: PSI-MOD-slim
xref: Origin: "X"
xref: Source: "natural"
xref: TermSpec: "none"
is_a: MOD:00009 ! natural residue
is_a: MOD:01156 ! protein modification categorized by chemical process

[Term]
id: MOD:02089
name: O-(phospho-5'-uridine)-L-serine
def: "A protein modification that effectively crosslinks an L-serine residue and 5'-phosphouridine through a phosphodiester bond to form O-(phospho-5'-uridine)-L-serine." [DeltaMass:0, PubMed:22504181, Unimod:417#S, ChEBI:156051]
subset: PSI-MOD-slim
synonym: "MOD_RES O-UMP-serine" EXACT UniProt-feature []
synonym: "OUMPSer" EXACT PSI-MOD-label []
synonym: "PhosphoUridine" RELATED PSI-MS-label []
xref: DiffAvg: "306.17"
xref: DiffFormula: "C 9 H 11 N 2 O 8 P 1"
xref: DiffMono: "306.025302"
xref: Formula: "C 12 H 16 N 3 O 9 P 1"
xref: MassAvg: "377.24"
xref: MassMono: "377.062416"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:417"
xref: uniprot.ptm:PTM-0501
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01166 ! uridylated residue

[Term]
id: MOD:02090
name: O-(phospho-5'-uridine)-L-threonine
def: "A protein modification that effectively modifies an L-threonine residue with 5'-phosphouridine through a phosphodiester bond to form O-(phospho-5'-uridine)-L-threonine." [DeltaMass:0, PubMed:22504181, Unimod:417#T, ChEBI:156052]
subset: PSI-MOD-slim
synonym: "MOD_RES O-UMP-threonine" EXACT UniProt-feature []
synonym: "OUMPThr" EXACT PSI-MOD-label []
synonym: "PhosphoUridine" RELATED PSI-MS-label []
xref: DiffAvg: "306.17"
xref: DiffFormula: "C 9 H 11 N 2 O 8 P 1"
xref: DiffMono: "306.025302"
xref: Formula: "C 13 H 18 N 3 O 9 P 1"
xref: MassAvg: "391.27"
xref: MassMono: "391.078066"
xref: Origin: "T"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:417"
xref: uniprot.ptm:PTM-0502
is_a: MOD:00917 ! modified L-threonine residue
is_a: MOD:01166 ! uridylated residue

[Term]
id: MOD:02091
name: O-(phospho-5'-adenosine)-L-serine
def: "A protein modification that effectively modifies an L-serine residue with 5'-phosphoadenosine through a phosphodiester bond to form O-(phospho-5'-adenosine)-L-serine." [PubMed:21472612, Unimod:405#S]
subset: PSI-MOD-slim
synonym: "MOD_RES O-AMP-serine" EXACT UniProt-feature []
synonym: "Phosphoadenosine" RELATED PSI-MS-label []
xref: DiffAvg: "329.21"
xref: DiffFormula: "C 10 H 12 N 5 O 6 P 1"
xref: DiffMono: "329.052520"
xref: Formula: "C 13 H 17 N 6 O 8 P 1"
xref: MassAvg: "416.28"
xref: MassMono: "416.084549"
xref: Origin: "S"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:405"
xref: uniprot.ptm:PTM-0651
is_a: MOD:00916 ! modified L-serine residue
is_a: MOD:01165 ! adenylated residue

[Term]
id: MOD:02092
name: S-methylbutanedioic acid-L-cysteine
def: "A protein modification that effectively converts an L-cysteine residue to form S-methylbutanedioic acid-L-cysteine by alkylation with itaconate through a thioether bond." [PubMed:29590092]
subset: PSI-MOD-slim
synonym: "MOD_RES S-(2,3-dicarboxypropyl)cysteine" EXACT UniProt-feature []
xref: DiffAvg: "130.10"
xref: DiffFormula: "C 5 H 6 N 0 O 4 P 0 S 0"
xref: DiffMono: "130.026609"
xref: Formula: "C 8 H 11 N 1 O 5 P 0 S 1"
xref: MassAvg: "233.24"
xref: MassMono: "233.035793"
xref: Origin: "C"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0676
is_a: MOD:00905 ! modified L-cysteine residue
is_a: MOD:00001 ! alkylated residue

[Term]
id: MOD:02093
name: N6-(2-hydroxyisobutanoyl)-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-(2-hydroxyisobutanoyl)-L-lysine." [PubMed:29775581, PubMed:24681537, ChEBI:144968, Unimod:1849]
synonym: "MOD_RES N6-(2-hydroxyisobutyryl)lysine" EXACT UniProt-feature []
xref: DiffAvg: "86.09"
xref: DiffFormula: "C 4 H 6 N 0 O 2"
xref: DiffMono: "86.036779"
xref: Formula: "C 10 H 18 N 2 O 3"
xref: MassAvg: "214.27"
xref: MassMono: "214.131742"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: Unimod: "Unimod:1849"
xref: uniprot.ptm:PTM-0638
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:02094
name: N6-((3R)-3-hydroxybutanoyl)-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-((3R)-3-hydroxybutanoyl)-L-lysine." [PubMed:27105115, ChEBI:149490]
synonym: "MOD_RES N6-(beta-hydroxybutyryl)lysine" EXACT UniProt-feature []
xref: DiffAvg: "86.09"
xref: DiffFormula: "C 4 H 6 N 0 O 2"
xref: DiffMono: "86.036779"
xref: Formula: "C 10 H 18 N 2 O 3"
xref: MassAvg: "214.27"
xref: MassMono: "214.131742"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0499
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:02095
name: N6-glutaryl-L-lysine
def: "A protein modification that effectively converts an L-lysine residue to N6-glutaryl-L-lysine." [PubMed:24703693, ChEBI:87828]
synonym: "MOD_RES N6-glutaryllysine" EXACT UniProt-feature []
xref: DiffAvg: "114.10"
xref: DiffFormula: "C 5 H 6 N 0 O 3"
xref: DiffMono: "114.031694"
xref: Formula: "C 11 H 18 N 2 O 4"
xref: MassAvg: "242.28"
xref: MassMono: "242.126657"
xref: Origin: "K"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0487
is_a: MOD:01875 ! N6-acylated L-lysine

[Term]
id: MOD:02096
name: N4-methyl-D-asparagine
def: "A protein modification that effectively converts a D-asparagine residue to N4-methyl-D-asparagine." [PubMed:22983711, ChEBI:149514]
subset: PSI-MOD-slim
synonym: "MOD_RES N4-methyl-D-asparagine" EXACT UniProt-feature []
synonym: "N4-methylated D-asparagine" EXACT PSI-MOD-alternate []
xref: DiffAvg: "14.03"
xref: DiffFormula: "C 1 H 2 N 0 O 0"
xref: DiffMono: "14.015650"
xref: Formula: "C 5 H 8 N 2 O 2"
xref: MassAvg: "128.13"
xref: MassMono: "128.058578"
xref: Origin: "N"
xref: Source: "natural"
xref: TermSpec: "none"
xref: uniprot.ptm:PTM-0691
is_a: MOD:00599 ! monomethylated residue
is_a: MOD:00602 ! N-methylated residue
is_a: MOD:00673 ! methylated asparagine
is_a: MOD:02097 ! modified D-asparagine residue
is_a: MOD:00894 ! residues isobaric at 128.058578 Da

[Term]
id: MOD:02097
name: modified D-asparagine residue
def: "A protein modification that modifies a D-asparagine residue." [PubMed:18688235]
subset: PSI-MOD-slim
synonym: "ModDAsn" EXACT PSI-MOD-label []
is_a: MOD:00203 ! D-asparagine

[Typedef]
id: contains
name: contains
def: "'Entity A' contains 'Entity B' implies that 'Entity B' is a part of the structure of 'Entity A'." [PubMed:18688235]
comment: The inverse relationship to "part of".
is_transitive: true

[Typedef]
id: derives_from
name: derives from
def: "'Entity A' derives_from 'Entity B' implies that 'Entity A' is chemically derived from 'Entity B'." [PubMed:18688235]
is_transitive: true

[Typedef]
id: has_functional_parent
name: has functional parent
def: "'Entity A' has_functional_parent 'Entity B' implies that 'Entity B' has at least one chacteristic group from which 'Entity A' can be derived by functional modification." [PubMed:18688235]
comment: This relationship indicates that the formula and mass of the child are not inherited from the mass of the parent.
is_transitive: true

[Typedef]
id: part_of
name: part of
def: "'Entity A' part_of 'Entity B' implies that 'Entity A' is a part of the structure of 'Entity B'." [PubMed:18688235]
is_transitive: true