20:02:2021 14:36 PSI-MOD 1.2 Joshua Klein Annotation note 01 - "[PSI-MOD:ref]" has been replaced by PubMed:18688235. Annotation note 02 - When an entry in the RESID Database is annotated with different sources because the same modification can arise from different encoded amino acids, then the PSI-MOD definition for each different source instance carries the RESID cross-reference followed by a hash symbol "#" and a 3 or 4 character label. When an entry in the RESID Database is annotated as a general modification with the same enzymatic activity producing different chemical structures depending on natural variation in the nonproteinaceous substrate, on secondary modifications that do not change the nature of the primary modification, or on a combination of a primary and one or more secondary modifications on the same residue, then the PSI-MOD definition for each different instance carries the RESID cross-reference followed by the special tag "#var". Annotation note 03 - When an entry in the Unimod database is annotated as a general modification, and one or more instance sites are listed, then the PSI-MOD definition for each different site instance carries the Unimod cross-reference followed by a hash symbol and an amino acid code, "N-term" or "C-term". Annotation note 04 - The elemental formulas are in strict alphabetical order, not in CAS ("C" and "H" first) order. Isotope numbers are in parentheses before the element symbol, and an element should not occur in a formula both with and without an isotope number. In difference formulas, counts can be zero or negative. Annotation note 05 - In entries with an isotope indicator in the formula, average masses are meaningless and are assigned the value equal to the monoisotopic mass, but rounded to a lower precision; monoisotopic masses are calculated by using the masses for the indicated isotopes and the most common isotopes for other elements without isotope indicators in the formulas. Annotation note 06 - For cross-link modifications, the number following "Cross-link" in the comment record indicates the number of amino acid residues that appear in the origin record, used to check the difference formula and masses. This usage differs from RESID, where the cross-link number indicates the maximum number of peptide chains that can be cross-linked. Annotation note 07 - The synonym cross-reference "MOD:old name" has been replaced by "MOD:alternate name". Annotation note 08 - The DeltaMass listings for free amino acids have been removed. Most Unimod entries that have not been "approved" have by general agreement not been incorporated unless there has been a request for a specific term by a PRIDE submitter. Annotation note 09 - The Open Mass Spectrometry Search Algorithm, OMSSA, enumerated list of modifications are being incorporated. The string values are synonyms with the synonymtypedef "OMSSA-label", and their integer values (which are supposed to be stable) are definition cross-references. Annotation note 10 - GNOme is the Glycan Naming and Subsumption Ontology (https://gnome.glyomics.org/), an ontology for the support of glycomics. PSI-MOD does not have all possible glycans in its entries, just the ones that are noted to be on proteins and have been requested for addition. GNOme uses GlyTouCan (http://glytoucan.org/) to provide stable accessions for glycans described at varyious degrees of characterization, including compositions (no linkage) and topologies (no carbon bond positions or anomeric configurations). ISO-8601 date: 2022-02-20 20:36Z PSI-MOD version: 1.031.4 RESID release: 75.00 definition term replaced by Label from MS DeltaMass Short label from OMSSA Alternate name curated by PSI-MOD Short label curated by PSI-MOD subset of protein modifications Agreed label from MS community Alternate name from RESID Misnomer tagged alternate name from RESID Name from RESID Systematic name from RESID Protein feature description from UniProtKB Alternate name from Unimod Description (full_name) from Unimod Interim label from Unimod subset_property synonym_type_property database_cross_reference has_exact_synonym has_obo_format_version has_obo_namespace has_related_synonym has_scope has_synonym_type in_subset 'Entity A' contains 'Entity B' implies that 'Entity B' is a part of the structure of 'Entity A'. PSI-MOD contains The inverse relationship to "part of". contains 'Entity A' contains 'Entity B' implies that 'Entity B' is a part of the structure of 'Entity A'. PubMed:18688235 'Entity A' derives_from 'Entity B' implies that 'Entity A' is chemically derived from 'Entity B'. PSI-MOD derives_from derives from 'Entity A' derives_from 'Entity B' implies that 'Entity A' is chemically derived from 'Entity B'. PubMed:18688235 'Entity A' has_functional_parent 'Entity B' implies that 'Entity B' has at least one chacteristic group from which 'Entity A' can be derived by functional modification. PSI-MOD has_functional_parent This relationship indicates that the formula and mass of the child are not inherited from the mass of the parent. has functional parent 'Entity A' has_functional_parent 'Entity B' implies that 'Entity B' has at least one chacteristic group from which 'Entity A' can be derived by functional modification. PubMed:18688235 'Entity A' part_of 'Entity B' implies that 'Entity A' is a part of the structure of 'Entity B'. PSI-MOD part_of part of 'Entity A' part_of 'Entity B' implies that 'Entity A' is a part of the structure of 'Entity B'. PubMed:18688235 Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue. ModRes PSI-MOD MOD:00000 protein modification Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue. PubMed:18688235 ModRes A protein modification that effectively replaces a hydrogen atom with an alkyl group. AlkylRes PSI-MOD MOD:00001 alkylated residue A protein modification that effectively replaces a hydrogen atom with an alkyl group. PubMed:18688235 AlkylRes A protein modification that effectively converts an L-serine residue to O3-glycosylserine. S natural OGlycoSer PSI-MOD MOD:00002 O-glycosyl-L-serine OGlycoSer A protein modification that effectively converts an L-serine residue to O3-glycosylserine. PubMed:18688235 Entry from Unimod. PSI-MOD MOD:00003 This term is for organizational use only and should not be assigned. [JSG] Unimod Entry from Unimod. PubMed:18688235 Artifact entry from Unimod - OBSOLETE because organizational use is no longer required. PSI-MOD MOD:00004 artifact true Artifact entry from Unimod - OBSOLETE because organizational use is no longer required. PubMed:18688235 A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine. T natural OGlycoThr PSI-MOD MOD:00005 O-glycosyl-L-threonine A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine. PubMed:18688235 OGlycoThr A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond. NGlycoRes PSI-MOD MOD:00006 N-glycosylated residue A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond. PubMed:18688235 NGlycoRes A protein modification that effectively substitutes a selenium atom for a sulfur atom. 46.91 C 0 H 0 N 0 O 0 S -1 Se 1 47.94445 X natural Unimod:162 Se(S)Res PSI-MOD Delta:S(-1)Se(1) Selenium replaces sulphur MOD:00007 selenium substitution for sulfur A protein modification that effectively substitutes a selenium atom for a sulfur atom. PubMed:12148805 Unimod:162 Se(S)Res Delta:S(-1)Se(1) Selenium replaces sulphur Entry from Unimod representing one or more entries in RESID. OBSOLETE because organizational use is no longer required. PSI-MOD MOD:00008 common true Entry from Unimod representing one or more entries in RESID. OBSOLETE because organizational use is no longer required. PubMed:18688235 A protein modification that removes a residue, or inserts or replaces a residue with a natural, standard or nonstandard, encoded residue. X natural Res alpha-amino acid PSI-MOD MOD:00009 natural residue A protein modification that removes a residue, or inserts or replaces a residue with a natural, standard or nonstandard, encoded residue. PubMed:6692818 RESID:AA0000 Res alpha-amino acid A protein modification that effectively converts a source amino acid residue to an L-alanine. 0.0 C 0 H 0 N 0 O 0 0.0 C 3 H 5 N 1 O 1 71.08 71.03712 A natural (2S)-2-aminopropanoic acid 2-aminopropionic acid 2-azanylpropanoic acid Ala L-alanine alpha-alanine alpha-aminopropionic acid PSI-MOD MOD:00010 L-alanine residue A protein modification that effectively converts a source amino acid residue to an L-alanine. ChEBI:29948 DeltaMass:0 PubMed:6692818 RESID:AA0001 (2S)-2-aminopropanoic acid 2-aminopropionic acid 2-azanylpropanoic acid Ala L-alanine alpha-alanine alpha-aminopropionic acid A protein modification that effectively converts a source amino acid residue to an L-arginine. 0.0 C 0 H 0 N 0 O 0 0.0 C 6 H 12 N 4 O 1 156.19 156.1011 R natural (2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid 2-amino-5-(carbamimidamido)pentanoic acid [tautomer] 2-amino-5-[(aminoiminomethyl)amino]pentanoic acid [tautomer] 2-amino-5-guanidinopentanoic acid 2-amino-5-guanidinovaleric acid 2-azanyl-5-[bis(azanyl)methylideneazanyl]pentanoic acid Arg L-arginine alpha-amino-delta-guanidinovaleric acid PSI-MOD MOD:00011 L-arginine residue A protein modification that effectively converts a source amino acid residue to an L-arginine. ChEBI:29952 DeltaMass:0 PubMed:518876 PubMed:6692818 RESID:AA0002 (2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid 2-amino-5-(carbamimidamido)pentanoic acid [tautomer] 2-amino-5-[(aminoiminomethyl)amino]pentanoic acid [tautomer] 2-amino-5-guanidinopentanoic acid 2-amino-5-guanidinovaleric acid 2-azanyl-5-[bis(azanyl)methylideneazanyl]pentanoic acid Arg L-arginine alpha-amino-delta-guanidinovaleric acid A protein modification that effectively converts a source amino acid residue to an L-asparagine. 0.0 C 0 H 0 N 0 O 0 0.0 C 4 H 6 N 2 O 2 114.1 114.04293 N natural (2S)-2-amino-4-butanediamic acid 2,4-bis(azanyl)-4-oxobutanoic acid 2,4-diamino-4-oxobutanoic acid 2-amino-3-carbamoylpropanoic acid 2-amino-4-butanediamic acid 2-aminosuccinamic acid 2-aminosuccinic acid 4-amide Asn L-asparagine alpha-amino-beta-carbamylpropionic acid alpha-aminosuccinamic acid aspartic acid 4-amide aspartic acid beta-amide beta-asparagine PSI-MOD MOD:00012 L-asparagine residue A protein modification that effectively converts a source amino acid residue to an L-asparagine. ChEBI:29956 DeltaMass:0 PubMed:15736973 PubMed:5681232 PubMed:6692818 PubMed:9789001 RESID:AA0003 (2S)-2-amino-4-butanediamic acid 2,4-bis(azanyl)-4-oxobutanoic acid 2,4-diamino-4-oxobutanoic acid 2-amino-3-carbamoylpropanoic acid 2-amino-4-butanediamic acid 2-aminosuccinamic acid 2-aminosuccinic acid 4-amide Asn L-asparagine alpha-amino-beta-carbamylpropionic acid alpha-aminosuccinamic acid aspartic acid 4-amide aspartic acid beta-amide beta-asparagine A protein modification that effectively converts a source amino acid residue to an L-aspartic acid. 0.0 C 0 H 0 N 0 O 0 0.0 C 4 H 5 N 1 O 3 115.09 115.02694 D natural (2S)-2-aminobutanedioic acid 2-azanylbutanedioic acid Asp L-aspartic acid aminosuccinic acid PSI-MOD MOD:00013 L-aspartic acid residue A protein modification that effectively converts a source amino acid residue to an L-aspartic acid. ChEBI:29958 DeltaMass:0 PubMed:1097438 PubMed:339692 PubMed:4399050 PubMed:5764436 PubMed:6692818 PubMed:8089117 PubMed:9521123 PubMed:9582379 RESID:AA0004 (2S)-2-aminobutanedioic acid 2-azanylbutanedioic acid Asp L-aspartic acid aminosuccinic acid A protein modification that effectively converts a source amino acid residue to an L-cysteine. 0.0 C 0 H 0 N 0 O 0 S 0 0.0 C 3 H 5 N 1 O 1 S 1 103.14 103.009186 C natural (2R)-2-amino-3-sulfanylpropanoic acid (R)-cysteine 2-amino-3-mercaptopropanoic acid 2-amino-3-mercaptopropionic acid 2-azanyl-3-sulfanylpropanoic acid 3-mercapto-L-alanine Cys Cysteine (C, Cys) L-(+)-cysteine L-cysteine alpha-amino-beta-mercaptopropanoic acid alpha-amino-beta-mercaptopropionic acid alpha-amino-beta-thiolpropionic acid beta-mercaptoalanine half-cystine thioserine PSI-MOD MOD:00014 From DeltaMass: Average Mass: 121. L-cysteine residue A protein modification that effectively converts a source amino acid residue to an L-cysteine. ChEBI:29950 DeltaMass:0 PubMed:1310545 PubMed:15790858 PubMed:3447159 PubMed:6692818 PubMed:7338899 RESID:AA0005 (2R)-2-amino-3-sulfanylpropanoic acid (R)-cysteine 2-amino-3-mercaptopropanoic acid 2-amino-3-mercaptopropionic acid 2-azanyl-3-sulfanylpropanoic acid 3-mercapto-L-alanine Cys Cysteine (C, Cys) L-(+)-cysteine L-cysteine alpha-amino-beta-mercaptopropanoic acid alpha-amino-beta-mercaptopropionic acid alpha-amino-beta-thiolpropionic acid beta-mercaptoalanine half-cystine thioserine A protein modification that effectively converts a source amino acid residue to an L-glutamic acid. 0.0 C 0 H 0 N 0 O 0 0.0 C 5 H 7 N 1 O 3 129.12 129.04259 E natural (2S)-2-aminopentanedioic acid 1-aminopropane-1,3-dicarboxylic acid 2-aminoglutaric acid 2-azanylpentanedioic acid Glu L-glutamic acid alpha-aminoglutaric acid glutaminic acid PSI-MOD MOD:00015 L-glutamic acid residue A protein modification that effectively converts a source amino acid residue to an L-glutamic acid. ChEBI:29972 DeltaMass:0 PubMed:1881881 PubMed:4565668 PubMed:4922541 PubMed:6692818 PubMed:9326660 PubMed:957425 RESID:AA0006 (2S)-2-aminopentanedioic acid 1-aminopropane-1,3-dicarboxylic acid 2-aminoglutaric acid 2-azanylpentanedioic acid Glu L-glutamic acid alpha-aminoglutaric acid glutaminic acid A protein modification that effectively converts a source amino acid residue to an L-glutamine. 0.0 C 0 H 0 N 0 O 0 0.0 C 5 H 8 N 2 O 2 128.13 128.05858 Q natural (2S)-2-amino-5-pentanediamic acid 2,5-bis(azanyl)-5-oxopentanoic acid 2,5-diamino-5-oxopentanoic acid 2-amino-4-carbamoylbutanoic acid 2-aminoglutaramic acid Gln L-glutamine alpha-amino-gamma-carbamylbutyric acid glutamic acid 5-amide glutamic acid gamma-amide glutamide PSI-MOD MOD:00016 L-glutamine residue glutamic acid gamma-amide glutamide A protein modification that effectively converts a source amino acid residue to an L-glutamine. ChEBI:30011 DeltaMass:0 PubMed:3340166 PubMed:6692818 PubMed:9342308 RESID:AA0007 (2S)-2-amino-5-pentanediamic acid 2,5-bis(azanyl)-5-oxopentanoic acid 2,5-diamino-5-oxopentanoic acid 2-amino-4-carbamoylbutanoic acid 2-aminoglutaramic acid Gln L-glutamine alpha-amino-gamma-carbamylbutyric acid glutamic acid 5-amide A protein modification that effectively converts a source amino acid residue to a glycine. 0.0 C 0 H 0 N 0 O 0 0.0 C 2 H 3 N 1 O 1 57.05 57.021465 G natural Gly aminoacetic acid aminoethanoic acid azanylethanoic acid glycine glycocoll PSI-MOD MOD:00017 glycine residue A protein modification that effectively converts a source amino acid residue to a glycine. ChEBI:29947 DeltaMass:0 PubMed:1310545 PubMed:6692818 RESID:AA0008 Gly aminoacetic acid aminoethanoic acid azanylethanoic acid glycine glycocoll A protein modification that effectively converts a source amino acid residue to an L-histidine. 0.0 C 0 H 0 N 0 O 0 0.0 C 6 H 7 N 3 O 1 137.14 137.05891 H natural (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid [tautomer] 2-azanyl-3-(1H-imidazol-4-yl)propanoic acid 2-azanyl-3-(1H-imidazol-5-yl)propanoic acid [tautomer] 4-(2-amino-2-carboxyethyl)imidazole His L-histidine alpha-amino-beta-(4-imidazole)propionic acid glyoxaline-5-alanine PSI-MOD MOD:00018 L-histidine residue A protein modification that effectively converts a source amino acid residue to an L-histidine. ChEBI:29979 DeltaMass:0 PubMed:14342316 PubMed:2722967 PubMed:512 PubMed:5460889 PubMed:6129252 PubMed:6692818 PubMed:6876174 RESID:AA0009 (2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid [tautomer] 2-azanyl-3-(1H-imidazol-4-yl)propanoic acid 2-azanyl-3-(1H-imidazol-5-yl)propanoic acid [tautomer] 4-(2-amino-2-carboxyethyl)imidazole His L-histidine alpha-amino-beta-(4-imidazole)propionic acid glyoxaline-5-alanine A protein modification that effectively converts a source amino acid residue to an L-isoleucine. 0.0 C 0 H 0 N 0 O 0 0.0 C 6 H 11 N 1 O 1 113.16 113.08406 I natural (2S,3S)-2-amino-3-methylpentanoic acid 2-azanyl-3-methylpentanoic acid 3-methyl-norvaline Ile Isoleucyl L-erythro-isoleucine L-isoleucine alpha-amino-beta-methylvaleric acid PSI-MOD MOD:00019 L-isoleucine residue A protein modification that effectively converts a source amino acid residue to an L-isoleucine. ChEBI:30009 DeltaMass:0 PubMed:6692818 RESID:AA0010 (2S,3S)-2-amino-3-methylpentanoic acid 2-azanyl-3-methylpentanoic acid 3-methyl-norvaline Ile Isoleucyl L-erythro-isoleucine L-isoleucine alpha-amino-beta-methylvaleric acid A protein modification that effectively converts a source amino acid residue to an L-leucine. 0.0 C 0 H 0 N 0 O 0 0.0 C 6 H 11 N 1 O 1 113.16 113.08406 L natural (2S)-2-amino-4-methylpentanoic acid 2-azanyl-4-methylpentanoic acid 4-methyl-norvaline L-leucine Leu alpha-amino-gamma-methylvaleric acid alpha-aminoisocaproic acid PSI-MOD MOD:00020 L-leucine residue A protein modification that effectively converts a source amino acid residue to an L-leucine. ChEBI:30006 DeltaMass:0 PubMed:11478885 PubMed:6692818 RESID:AA0011 (2S)-2-amino-4-methylpentanoic acid 2-azanyl-4-methylpentanoic acid 4-methyl-norvaline L-leucine Leu alpha-amino-gamma-methylvaleric acid alpha-aminoisocaproic acid A protein modification that effectively converts a source amino acid residue to L-lysine. 0.0 C 0 H 0 N 0 O 0 0.0 C 6 H 12 N 2 O 1 128.18 128.09496 K natural (2S)-2,6-diaminohexanoic acid 2,6-bis(azanyl)hexanoic acid 6-amino-L-norleucine ACT_SITE Schiff-base intermediate with substrate L-lysine Lys alpha,epsilon-diaminocaproic acid PSI-MOD MOD:00021 L-lysine residue A protein modification that effectively converts a source amino acid residue to L-lysine. ChEBI:29967 DeltaMass:0 PubMed:3106962 PubMed:6120171 PubMed:6692818 RESID:AA0012 (2S)-2,6-diaminohexanoic acid 2,6-bis(azanyl)hexanoic acid 6-amino-L-norleucine ACT_SITE Schiff-base intermediate with substrate L-lysine Lys alpha,epsilon-diaminocaproic acid A protein modification that effectively converts a source amino acid residue to L-methionine. 0.0 C 0 H 0 N 0 O 0 S 0 0.0 C 5 H 9 N 1 O 1 S 1 131.19 131.04048 M natural (2S)-2-amino-4-(methylsulfanyl)butanoic acid 2-amino-4-(methylthio)butanoic acid 2-amino-4-(methylthio)butyric acid 2-azanyl-4-(methylsulfanyl)butanoic acid L-(-)-methionine L-methionine Met S-methyl-L-homocysteine alpha-amino-gamma-methylmercaptobutyric acid alpha-amino-gamma-methylthiobutyric acid gamma-methylthio-alpha-aminobutyric acid PSI-MOD MOD:00022 From DeltaMass: Average Mass: 149 L-methionine residue A protein modification that effectively converts a source amino acid residue to L-methionine. ChEBI:29983 DeltaMass:0 PubMed:6411710 PubMed:6692818 RESID:AA0013 (2S)-2-amino-4-(methylsulfanyl)butanoic acid 2-amino-4-(methylthio)butanoic acid 2-amino-4-(methylthio)butyric acid 2-azanyl-4-(methylsulfanyl)butanoic acid L-(-)-methionine L-methionine Met S-methyl-L-homocysteine alpha-amino-gamma-methylmercaptobutyric acid alpha-amino-gamma-methylthiobutyric acid gamma-methylthio-alpha-aminobutyric acid A protein modification that effectively converts a source amino acid residue to L-phenylalanine. 0.0 C 0 H 0 N 0 O 0 0.0 C 9 H 9 N 1 O 1 147.18 147.06842 F natural (2S)-2-amino-3-phenylpropanoic acid 2-azanyl-3-phenylpropanoic acid L-phenylalanine Phe alpha-amino-beta-phenylpropionic acid PSI-MOD MOD:00023 L-phenylalanine residue A protein modification that effectively converts a source amino acid residue to L-phenylalanine. ChEBI:29997 DeltaMass:0 PubMed:6692818 RESID:AA0014 (2S)-2-amino-3-phenylpropanoic acid 2-azanyl-3-phenylpropanoic acid L-phenylalanine Phe alpha-amino-beta-phenylpropionic acid A protein modification that effectively converts a source amino acid residue to L-proline. 0.0 C 0 H 0 N 0 O 0 0.0 C 5 H 7 N 1 O 1 97.12 97.052765 P natural (2S)-2-pyrrolidinecarboxylic acid L-proline Pro pyrrolidine-2-carboxylic acid PSI-MOD MOD:00024 L-proline residue A protein modification that effectively converts a source amino acid residue to L-proline. ChEBI:30017 DeltaMass:0 PubMed:6692818 PubMed:8547259 RESID:AA0015 (2S)-2-pyrrolidinecarboxylic acid L-proline Pro pyrrolidine-2-carboxylic acid A protein modification that effectively converts a source amino acid residue to L-serine. 0.0 C 0 H 0 N 0 O 0 0.0 C 3 H 5 N 1 O 2 87.08 87.03203 S natural (2S)-2-amino-3-hydroxypropanoic acid 2-azanyl-3-hydroxypropanoic acid 3-hydroxy-L-alanine L-serine Ser alpha-amino-beta-hydroxypropionic acid beta-hydroxyalanine PSI-MOD MOD:00025 L-serine residue A protein modification that effectively converts a source amino acid residue to L-serine. ChEBI:29999 DeltaMass:0 PubMed:4399050 PubMed:6692818 RESID:AA0016 (2S)-2-amino-3-hydroxypropanoic acid 2-azanyl-3-hydroxypropanoic acid 3-hydroxy-L-alanine L-serine Ser alpha-amino-beta-hydroxypropionic acid beta-hydroxyalanine A protein modification that effectively converts a source amino acid residue to L-threonine. 0.0 C 0 H 0 N 0 O 0 0.0 C 4 H 7 N 1 O 2 101.1 101.047676 T natural (2S,3R)-2-amino-3-hydroxybutanoic acid 2-azanyl-3-hydroxybutanoic acid L-threo-threonine L-threonine Thr alpha-amino-beta-hydroxybutyric acid beta-methylserine PSI-MOD MOD:00026 L-threonine residue A protein modification that effectively converts a source amino acid residue to L-threonine. ChEBI:30013 DeltaMass:0 PubMed:2989287 PubMed:6692818 RESID:AA0017 (2S,3R)-2-amino-3-hydroxybutanoic acid 2-azanyl-3-hydroxybutanoic acid L-threo-threonine L-threonine Thr alpha-amino-beta-hydroxybutyric acid beta-methylserine A protein modification that effectively converts a source amino acid residue to L-tryptophan. 0.0 C 0 H 0 N 0 O 0 0.0 C 11 H 10 N 2 O 1 186.21 186.07932 W natural (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid 2-azanyl-3-(1H-indol-3-yl)propanoic acid L-tryptophan Trp alpha-amino-beta-(3-indolyl)propionoic acid beta(3-indolyl)alanine PSI-MOD MOD:00027 L-tryptophan residue A protein modification that effectively converts a source amino acid residue to L-tryptophan. ChEBI:29954 DeltaMass:0 PubMed:2059637 PubMed:6692818 PubMed:9324768 RESID:AA0018 (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid 2-azanyl-3-(1H-indol-3-yl)propanoic acid L-tryptophan Trp alpha-amino-beta-(3-indolyl)propionoic acid beta(3-indolyl)alanine A protein modification that effectively converts a source amino acid residue to L-tyrosine. 0.0 C 0 H 0 N 0 O 0 0.0 C 9 H 9 N 1 O 2 163.18 163.06332 Y natural (2S)-2-amino-3-(4-hydoxyphenyl)propanoic acid 2-azanyl-3-(4-hydoxyphenyl)propanoic acid L-tyrosine Tyr alpha-amino-beta-(para-hydroxyphenyl)propionic acid p-tyrosine para-hydroxyphenylalanine PSI-MOD MOD:00028 L-tyrosine residue A protein modification that effectively converts a source amino acid residue to L-tyrosine. ChEBI:29975 DeltaMass:0 PubMed:2190093 PubMed:2542938 PubMed:5550972 PubMed:6061414 PubMed:6120171 PubMed:6692818 RESID:AA0019 (2S)-2-amino-3-(4-hydoxyphenyl)propanoic acid 2-azanyl-3-(4-hydoxyphenyl)propanoic acid L-tyrosine Tyr alpha-amino-beta-(para-hydroxyphenyl)propionic acid p-tyrosine para-hydroxyphenylalanine A protein modification that effectively converts a source amino acid residue to an L-valine. 0.0 C 0 H 0 N 0 O 0 0.0 C 5 H 9 N 1 O 1 99.13 99.06841 V natural (2S)-2-amino-3-methylbutanoic acid 2-azanyl-3-methylbutanoic acid L-valine Val alpha-amino-beta-methylbutyric acid alpha-aminoisovaleric acid PSI-MOD MOD:00029 L-valine residue A protein modification that effectively converts a source amino acid residue to an L-valine. ChEBI:30015 DeltaMass:0 PubMed:6692818 RESID:AA0020 (2S)-2-amino-3-methylbutanoic acid 2-azanyl-3-methylbutanoic acid L-valine Val alpha-amino-beta-methylbutyric acid alpha-aminoisovaleric acid A protein modification that effectively converts a source amino acid residue to an N-formyl-L-methionine, a natural pretranslational modification. 0.0 C 0 H 0 N 0 O 0 S 0 0.0 C 6 H 10 N 1 O 2 S 1 160.21 160.04323 M natural N-term (2S)-2-formylamino-4-(methylsulfanyl)butanoic acid 2-formamido-4-(methylsulfanyl)butanoic acid 2-formylamino-4-(methylthio)butanoic acid 2-formylazanyl-4-(methylsulfanyl)butanoic acid MOD_RES N-formylmethionine N-formyl-L-methionine N-formylated L-methionine fMet nformylmet PSI-MOD FormylMet MOD:00030 N-formyl-L-methionine residue A protein modification that effectively converts a source amino acid residue to an N-formyl-L-methionine, a natural pretranslational modification. ChEBI:33718 OMSSA:22 PubMed:10825024 PubMed:11152118 PubMed:2165784 PubMed:3042771 PubMed:8758896 RESID:AA0021#FMET (2S)-2-formylamino-4-(methylsulfanyl)butanoic acid 2-formamido-4-(methylsulfanyl)butanoic acid 2-formylamino-4-(methylthio)butanoic acid 2-formylazanyl-4-(methylsulfanyl)butanoic acid MOD_RES N-formylmethionine N-formyl-L-methionine N-formylated L-methionine fMet nformylmet FormylMet A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification. 0.0 C 0 H 0 N 0 O 0 Se 0 0.0 C 3 H 5 N 1 O 1 Se 1 150.05 150.95363 U natural (2R)-2-amino-3-selanylpropanoic acid 2-azanyl-3-selanylpropanoic acid 3-selenylalanine L-selenocysteine NON_STD Selenocysteine SeCys Sec selenium cysteine PSI-MOD MOD:00031 L-selenocysteine residue A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification. ChEBI:30000 PubMed:10523135 PubMed:1066676 PubMed:2037562 PubMed:2963330 PubMed:4734725 PubMed:6076213 PubMed:6217842 PubMed:6714945 RESID:AA0022 (2R)-2-amino-3-selanylpropanoic acid 2-azanyl-3-selanylpropanoic acid 3-selenylalanine L-selenocysteine NON_STD Selenocysteine SeCys Sec selenium cysteine A protein modification that is not chemically categorized. PSI-MOD MOD:00032 This term is for organizational use only and should not be assigned. [JSG] uncategorized protein modification A protein modification that is not chemically categorized. PubMed:18688235 A protein modification that crosslinks two or more amino acid residues with covalent bonds. XLNK-Res-Res PSI-MOD MOD:00033 The covalent bond is formed directly between sidechain atoms. If non-aminoacid atoms are involved in connecting two or more peptide chain residues peptide chain, the connection is classified as a multivalent binding site. crosslinked residues A protein modification that crosslinks two or more amino acid residues with covalent bonds. PubMed:18688235 XLNK-Res-Res A protein modification that effectively cross-links two L-cysteine residues to form L-cystine. -2.02 C 0 H -2 N 0 O 0 S 0 -2.01565 C 6 H 8 N 2 O 2 S 2 204.26 204.00272 C, C natural (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) 3,3'-dithiobis(2-aminopropanoic acid) 3,3'-dithiobisalanine 3,3'-dithiodialanine Cys2 Cystine ((Cys)2) DISULFID DISULFID Interchain L-cystine XLNK-SCys-SCys beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide beta,beta'-dithiodialanine bis(alpha-aminopropionic acid)-beta-disulfide bis(beta-amino-beta-carboxyethyl)disulfide dicysteine PSI-MOD 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid MOD:00034 Cross-link 2; for formation of a disulfide bond between a peptide cysteine and a free cysteine, see MOD:00765. L-cystine (cross-link) A protein modification that effectively cross-links two L-cysteine residues to form L-cystine. ChEBI:16283 DeltaMass:0 PubMed:1988019 PubMed:2001356 PubMed:2076469 PubMed:3083866 PubMed:366603 PubMed:7918467 PubMed:8344916 RESID:AA0025#CYS2 (2R,2'R)-3,3'-disulfane-1,2-diylbis(2-aminopropanoic acid) 3,3'-disulfane-1,2-diylbis(2-azanylpropanoic acid) 3,3'-dithiobis(2-aminopropanoic acid) 3,3'-dithiobisalanine 3,3'-dithiodialanine Cys2 Cystine ((Cys)2) DISULFID DISULFID Interchain L-cystine XLNK-SCys-SCys beta,beta'-diamino-beta,beta'-dicarboxydiethyldisulfide beta,beta'-dithiodialanine bis(alpha-aminopropionic acid)-beta-disulfide bis(beta-amino-beta-carboxyethyl)disulfide dicysteine 2-amino-3-(2-amino-2-carboxy-ethyl)disulfanyl-propanoic acid A protein modification that effectively converts an L-asparagine residue to (2S,3R)-3-hydroxyasparagine. 16.0 C 0 H 0 N 0 O 1 15.994915 C 4 H 6 N 2 O 3 130.1 130.03784 N natural PTM-0369 (2S,3R)-2,4-diamino-3-hydroxy-4-oxobutanoic acid (2S,3R)-2-amino-3-hydroxy-4-butanediamic acid (2S,3R)-3-hydroxyasparagine (3R)3HyAsn 2-azanyl-3-hydroxy-4-butanediamic acid L-erythro-beta-hydroxyasparagine MOD_RES (3R)-3-hydroxyasparagine erythro-beta-hydroxylated L-asparagine PSI-MOD MOD:00035 (2S,3R)-3-hydroxyasparagine A protein modification that effectively converts an L-asparagine residue to (2S,3R)-3-hydroxyasparagine. ChEBI:141853 PubMed:11823643 PubMed:2820791 RESID:AA0026 (2S,3R)-2,4-diamino-3-hydroxy-4-oxobutanoic acid (2S,3R)-2-amino-3-hydroxy-4-butanediamic acid (2S,3R)-3-hydroxyasparagine (3R)3HyAsn 2-azanyl-3-hydroxy-4-butanediamic acid L-erythro-beta-hydroxyasparagine MOD_RES (3R)-3-hydroxyasparagine erythro-beta-hydroxylated L-asparagine A protein modification that effectively converts an L-aspartic acid residue to (2S,3R)-3-hydroxyaspartic acid. 16.0 C 0 H 0 N 0 O 1 15.994915 C 4 H 5 N 1 O 4 131.09 131.02185 D natural PTM-0371 Unimod:35 (2S,3R)-2-amino-3-hydroxybutanedioic acid (2S,3R)-3-hydroxyaspartic acid (3R)3HyAsp 2-amino-3-hydroxysuccinic acid 2-azanyl-3-hydroxybutanedioic acid 3-hydroxyaspartic acid L-erythro-beta-hydroxyaspartic acid MOD_RES (3R)-3-hydroxyaspartate erythro-beta-hydroxylated L-aspartic acid hydroxylationd PSI-MOD Oxidation MOD:00036 (2S,3R)-3-hydroxyaspartic acid A protein modification that effectively converts an L-aspartic acid residue to (2S,3R)-3-hydroxyaspartic acid. ChEBI:141848 OMSSA:59 PubMed:6572939 PubMed:6871167 PubMed:8355279 RESID:AA0027 Unimod:35#D (2S,3R)-2-amino-3-hydroxybutanedioic acid (2S,3R)-3-hydroxyaspartic acid (3R)3HyAsp 2-amino-3-hydroxysuccinic acid 2-azanyl-3-hydroxybutanedioic acid 3-hydroxyaspartic acid L-erythro-beta-hydroxyaspartic acid MOD_RES (3R)-3-hydroxyaspartate erythro-beta-hydroxylated L-aspartic acid hydroxylationd Oxidation A protein modification that effectively converts an L-lysine residue to one of the diastereomeric 5-hydroxy-L-lysine residues. 16.0 C 0 H 0 N 0 O 1 15.994915 C 6 H 12 N 2 O 2 144.17 144.08987 K natural PTM-0044 5-hydroxylated L-lysine 5HyLys PSI-MOD MOD:00037 5-hydroxy-L-lysine A protein modification that effectively converts an L-lysine residue to one of the diastereomeric 5-hydroxy-L-lysine residues. ChEBI:60175 PubMed:18688235 5-hydroxylated L-lysine 5HyLys A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline. 16.0 C 0 H 0 N 0 O 1 15.994915 C 5 H 7 N 1 O 2 113.12 113.047676 P natural PTM-0030 (2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid 3-hydroxy-L-proline 3-hydroxylated L-proline 3-trans-hydroxy-L-proline 3HyPro L-threo-3-hydroxyproline MOD_RES 3-hydroxyproline beta-hydroxypyrrolidine-alpha-carboxylic acid PSI-MOD MOD:00038 3-hydroxy-L-proline A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline. ChEBI:16889 PubMed:2400108 PubMed:3734192 PubMed:4343807 RESID:AA0029 (2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid 3-hydroxy-L-proline 3-hydroxylated L-proline 3-trans-hydroxy-L-proline 3HyPro L-threo-3-hydroxyproline MOD_RES 3-hydroxyproline beta-hydroxypyrrolidine-alpha-carboxylic acid A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline 16.0 C 0 H 0 N 0 O 1 15.994915 C 5 H 7 N 1 O 2 113.12 113.047676 P natural PTM-0043 (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid 4-hydroxy-L-proline 4-hydroxylated L-proline 4-hydroxyproline 4-trans-hydroxy-L-proline 4HyPro L-threo-4-hydroxyproline MOD_RES 4-hydroxyproline gamma-hydroxypyrrolidine-alpha-carboxylic acid PSI-MOD MOD:00039 4-hydroxy-L-proline A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline ChEBI:18095 PubMed:11292863 PubMed:2400108 PubMed:3734192 RESID:AA0030 (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid 4-hydroxy-L-proline 4-hydroxylated L-proline 4-hydroxyproline 4-trans-hydroxy-L-proline 4HyPro L-threo-4-hydroxyproline MOD_RES 4-hydroxyproline gamma-hydroxypyrrolidine-alpha-carboxylic acid A protein modification that effectively converts an L-glutamine residue to 2-pyrrolidone-5-carboxylic acid. -17.03 C 0 H -3 N -1 O 0 -17.026548 C 5 H 6 N 1 O 2 112.11 112.039856 Q natural N-term PTM-0261 Unimod:28 (2S)-5-oxo-2-pyrrolidinecarboxylic acid 2-oxopyrrolidine-5-carboxylic acid 2-pyrrolidone-5-carboxylic acid 5-oxoproline 5-oxopyrrolidine-2-carboxylic acid 5-pyrrolidone-2-carboxylic acid MOD_RES Pyrrolidone carboxylic acid N-pyrrolidone carboxyl (N terminus) PCA PyrGlu(Gln) Pyroglutamic Acid formed from Gln Pyroglutamyl ntermpeppyroq pyroglutamic acid PSI-MOD Gln->pyro-Glu Pyro-glu from Q MOD:00040 DeltaMass gives a formula C 5 H 5 N 1 O 2 with mass 111.1 2-pyrrolidone-5-carboxylic acid (Gln) A protein modification that effectively converts an L-glutamine residue to 2-pyrrolidone-5-carboxylic acid. ChEBI:30652 DeltaMass:123 OMSSA:110 PubMed:10214721 PubMed:1836357 PubMed:26343 PubMed:3473473 RESID:AA0031#GLN Unimod:28#Q (2S)-5-oxo-2-pyrrolidinecarboxylic acid 2-oxopyrrolidine-5-carboxylic acid 2-pyrrolidone-5-carboxylic acid 5-oxoproline 5-oxopyrrolidine-2-carboxylic acid 5-pyrrolidone-2-carboxylic acid MOD_RES Pyrrolidone carboxylic acid N-pyrrolidone carboxyl (N terminus) PCA PyrGlu(Gln) Pyroglutamic Acid formed from Gln Pyroglutamyl ntermpeppyroq pyroglutamic acid Gln->pyro-Glu Pyro-glu from Q A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid. 44.01 C 1 H 0 N 0 O 2 43.98983 C 6 H 7 N 1 O 5 173.12 173.03242 E natural PTM-0039 Unimod:299 (3S)-3-aminopropane-1,1,3-tricarboxylic acid (3S)-3-azanylpropane-1,1,3-tricarboxylic acid 3-amino-1,1,3-propanetricarboxylic acid 3-azanylpropane-1,1,3-tricarboxylic acid 4-carboxyglutamic acid 4CbxGlu Carboxy Glutamyl L-gamma-carboxyglutamic acid MOD_RES 4-carboxyglutamate gamma-carboxylated L-glutamic acid gammacarboxyle PSI-MOD 1-carboxyglutamic acid Carboxy Carboxylation MOD:00041 DeltaMass has an incorrect formula C 6 H 7 N 5 O 1 (N and O reversed) with mass 173. L-gamma-carboxyglutamic acid A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid. DeltaMass:217 OMSSA:48 PubMed:10517147 PubMed:1807167 PubMed:3263814 PubMed:4528109 PubMed:7457858 PubMed:8135347 PubMed:8868490 PubMed:9188685 RESID:AA0032 Unimod:299#E (3S)-3-aminopropane-1,1,3-tricarboxylic acid (3S)-3-azanylpropane-1,1,3-tricarboxylic acid 3-amino-1,1,3-propanetricarboxylic acid 3-azanylpropane-1,1,3-tricarboxylic acid 4-carboxyglutamic acid 4CbxGlu Carboxy Glutamyl L-gamma-carboxyglutamic acid MOD_RES 4-carboxyglutamate gamma-carboxylated L-glutamic acid gammacarboxyle 1-carboxyglutamic acid Carboxy Carboxy Carboxylation A protein modification that effectively converts an L-aspartic acid residue to L-aspartic 4-phosphoric anhydride. 79.98 C 0 H 1 N 0 O 3 P 1 79.96633 C 4 H 6 N 1 O 6 P 1 195.07 194.99327 D natural PTM-0038 Unimod:21 (2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acid 2-aminobutanedioic 4-phosphoric anhydride 2-azanyl-4-oxo-4-(phosphonooxy)butanoic acid 4-oxo-O-phosphono-L-homoserine 4-phosphoaspartic acid 4-phosphorylated L-aspartatic acid ACT_SITE 4-aspartylphosphate intermediate L-aspartic 4-phosphoric anhydride MOD_RES 4-aspartylphosphate PAsp beta-aspartyl phosphate PSI-MOD Phospho Phosphorylation MOD:00042 L-aspartic 4-phosphoric anhydride A protein modification that effectively converts an L-aspartic acid residue to L-aspartic 4-phosphoric anhydride. ChEBI:15836 PubMed:4357737 RESID:AA0033 Unimod:21#D (2S)-2-amino-4-oxo-4-(phosphonooxy)butanoic acid 2-aminobutanedioic 4-phosphoric anhydride 2-azanyl-4-oxo-4-(phosphonooxy)butanoic acid 4-oxo-O-phosphono-L-homoserine 4-phosphoaspartic acid 4-phosphorylated L-aspartatic acid ACT_SITE 4-aspartylphosphate intermediate L-aspartic 4-phosphoric anhydride MOD_RES 4-aspartylphosphate PAsp beta-aspartyl phosphate Phospho Phosphorylation A protein modification that effectively converts an L-cysteine residue to S-phospho-L-cysteine. 79.98 C 0 H 1 N 0 O 3 P 1 S 0 79.96633 C 3 H 6 N 1 O 4 P 1 S 1 183.12 182.97551 C natural PTM-0251 Unimod:21 (2R)-2-amino-3-(phosphonosulfanyl)propanoic acid 2-azanyl-3-(phosphonosulfanyl)propanoic acid ACT_SITE Phosphocysteine intermediate MOD_RES Phosphocysteine PCys S-phospho-L-cysteine S-phosphonocysteine S-phosphorylated L-cysteine S3-phosphocysteine cysteine phosphate thioester PSI-MOD Phospho Phosphorylation MOD:00043 S-phospho-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-phospho-L-cysteine. PubMed:3142516 PubMed:7961745 PubMed:8128219 RESID:AA0034 Unimod:21#C (2R)-2-amino-3-(phosphonosulfanyl)propanoic acid 2-azanyl-3-(phosphonosulfanyl)propanoic acid ACT_SITE Phosphocysteine intermediate MOD_RES Phosphocysteine PCys S-phospho-L-cysteine S-phosphonocysteine S-phosphorylated L-cysteine S3-phosphocysteine cysteine phosphate thioester Phospho Phosphorylation A protein modification that effectively converts an L-histidine residue to tele-phospho-L-histidine (N-tau-phospho-L-histidine, 1'-phospho-L-histidine). 79.98 C 0 H 1 N 0 O 3 P 1 79.96633 C 6 H 8 N 3 O 4 P 1 217.12 217.02524 H natural PTM-0325 (2S)-2-amino-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid 1'-phospho-L-histidine 2-azanyl-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid ACT_SITE Tele-phosphohistidine intermediate MOD_RES Tele-phosphohistidine N(tau)-phosphohistidine N1-phosphonohistidine NE2-phosphonohistidine NtPHis Ntau-phosphorylated L-histidine histidine-N(epsilon)-phosphate histidine-N1'-phosphate tele-phosphohistidine PSI-MOD Phospho Phosphorylation histidine-3-phosphate MOD:00044 1'-phospho-L-histidine A protein modification that effectively converts an L-histidine residue to tele-phospho-L-histidine (N-tau-phospho-L-histidine, 1'-phospho-L-histidine). PubMed:11038361 PubMed:5642389 PubMed:6692818 RESID:AA0035 (2S)-2-amino-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid 1'-phospho-L-histidine 2-azanyl-3-(1-phosphono-1H-imidazol-4-yl)propanoic acid ACT_SITE Tele-phosphohistidine intermediate MOD_RES Tele-phosphohistidine N(tau)-phosphohistidine N1-phosphonohistidine NE2-phosphonohistidine NtPHis Ntau-phosphorylated L-histidine histidine-N(epsilon)-phosphate histidine-N1'-phosphate tele-phosphohistidine Phospho Phosphorylation histidine-3-phosphate A protein modification that effectively converts an L-histidine residue to pros-phospho-L-histidine (N-pi-phospho-L-histidine, 3'-phospho-L-histidine). 79.98 C 0 H 1 N 0 O 3 P 1 79.96633 C 6 H 8 N 3 O 4 P 1 217.12 217.02524 H natural PTM-0260 (2S)-2-amino-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid 2-azanyl-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid 3'-phospho-L-histidine ACT_SITE Pros-phosphohistidine intermediate MOD_RES Pros-phosphohistidine N(pi)-phosphohistidine N3-phosphonohistidine ND1-phosphonohistidine NpPHis Npi-phosphorylated L-histidine histidine-N(delta)-phosphate histidine-N3'-phosphate pros-phosphohistidine PSI-MOD Phospho Phosphorylation histidine-1-phosphate MOD:00045 3'-phospho-L-histidine A protein modification that effectively converts an L-histidine residue to pros-phospho-L-histidine (N-pi-phospho-L-histidine, 3'-phospho-L-histidine). PubMed:1549615 PubMed:5642389 PubMed:6692818 PubMed:7669763 PubMed:7803390 RESID:AA0036 (2S)-2-amino-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid 2-azanyl-3-(3-phosphono-3H-imidazol-4-yl)propanoic acid 3'-phospho-L-histidine ACT_SITE Pros-phosphohistidine intermediate MOD_RES Pros-phosphohistidine N(pi)-phosphohistidine N3-phosphonohistidine ND1-phosphonohistidine NpPHis Npi-phosphorylated L-histidine histidine-N(delta)-phosphate histidine-N3'-phosphate pros-phosphohistidine Phospho Phosphorylation histidine-1-phosphate A protein modification that effectively converts an L-serine residue to O-phospho-L-serine. 79.98 C 0 H 1 N 0 O 3 P 1 79.96633 C 3 H 6 N 1 O 5 P 1 167.06 166.99835 S natural PTM-0253 Unimod:21 (2S)-2-amino-3-(phosphonooxy)propanoic acid 2-amino-3-hydroxypropanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)propanoic acid ACT_SITE Phosphoserine intermediate MOD_RES Phosphoserine O-phospho-L-serine O-phosphonoserine O-phosphorylated L-serine O3-phosphoserine OPSer Phospho Seryl phosphorylations serine phosphate ester PSI-MOD Phospho Phosphorylation MOD:00046 O-phospho-L-serine A protein modification that effectively converts an L-serine residue to O-phospho-L-serine. ChEBI:15811 DeltaMass:0 OMSSA:6 PubMed:12923550 PubMed:4065410 PubMed:8061611 RESID:AA0037 Unimod:21#S (2S)-2-amino-3-(phosphonooxy)propanoic acid 2-amino-3-hydroxypropanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)propanoic acid ACT_SITE Phosphoserine intermediate MOD_RES Phosphoserine O-phospho-L-serine O-phosphonoserine O-phosphorylated L-serine O3-phosphoserine OPSer Phospho Seryl phosphorylations serine phosphate ester Phospho Phosphorylation A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine. 79.98 C 0 H 1 N 0 O 3 P 1 79.96633 C 4 H 8 N 1 O 5 P 1 181.08 181.014 T natural PTM-0254 Unimod:21 (2S,3R)-2-amino-3-(phosphonooxy)butanoic acid 2-amino-3-hydroxybutanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)butanoic acid MOD_RES Phosphothreonine O-phospho-L-threonine O-phosphorylated L-threonine O3-phosphothreonine OPThr Phospho Threonyl phosphorylationt threonine phosphate ester PSI-MOD Phospho Phosphorylation MOD:00047 O-phospho-L-threonine A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine. ChEBI:21967 DeltaMass:0 OMSSA:7 PubMed:12923550 PubMed:7678926 RESID:AA0038 Unimod:21#T (2S,3R)-2-amino-3-(phosphonooxy)butanoic acid 2-amino-3-hydroxybutanoic acid 3-phosphate 2-azanyl-3-(phosphonooxy)butanoic acid MOD_RES Phosphothreonine O-phospho-L-threonine O-phosphorylated L-threonine O3-phosphothreonine OPThr Phospho Threonyl phosphorylationt threonine phosphate ester Phospho Phosphorylation A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine. 79.98 C 0 H 1 N 0 O 3 P 1 79.96633 C 9 H 10 N 1 O 5 P 1 243.15 243.02966 Y natural PTM-0255 Unimod:21 (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine O4-phosphotyrosine OPTyr Phospho Tyrosinyl phosphorylationy tyrosine phosphate PSI-MOD Phospho Phosphorylation MOD:00048 O4'-phospho-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine. DeltaMass:0 OMSSA:8 PubMed:10226369 PubMed:1725475 RESID:AA0039 Unimod:21#Y (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid 2-amino-3-(4-hydroxyphenyl)propanoic acid 4'-phosphate 2-azanyl-3-(4-phosphonooxyphenyl)propanoic acid MOD_RES Phosphotyrosine O4'-phospho-L-tyrosine O4'-phosphorylated L-tyrosine O4-phosphotyrosine OPTyr Phospho Tyrosinyl phosphorylationy tyrosine phosphate Phospho Phosphorylation A protein modification that effectively converts an L-histidine residue to diphthamide. 143.21 C 7 H 15 N 2 O 1 143.11789 1+ C 13 H 22 N 5 O 2 280.35 280.1768 H natural PTM-0118 Unimod:375 (2R)-1-amino-4-(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-aminium (3-[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]-1-carbamoyl-propyl)-trimethylammonium 1-azanyl-4-(4-[2-azanyl-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-azanium 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine 2-[(R)-3-carboxamido-3-(trimethylammonio)propyl]-4-((S)-2-amino-2-carboxyethyl)-1H-imidazole 2-[3-carboxamido-3-(trimethylammonio)propyl]histidine 2-amino-3-[[2-(3-amino-3-carbamoyl-prop-1-enyl)-1,1,3-trimethyl-2,3-dihydroimidazol-5-yl]]propanoic acid 2-amino-4-[[5-(2-amino-2-carboxylato-ethyl)-1,1,3-trimethyl-2,3-dihydroimidazol-2-yl]]but-3-enamide Diphth MOD_RES Diphthamide alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-1H-imidazole-2-propanaminium diphthamide diphthamide (from histidine) PSI-MOD Diphthamide MOD:00049 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine A protein modification that effectively converts an L-histidine residue to diphthamide. ChEBI:16692 DeltaMass:122 PubMed:15316019 PubMed:7430147 RESID:AA0040 Unimod:375#H (2R)-1-amino-4-(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-aminium (3-[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]-1-carbamoyl-propyl)-trimethylammonium 1-azanyl-4-(4-[2-azanyl-2-carboxyethyl]-1H-imidazol-2-yl)-N,N,N-trimethyl-1-oxobutan-2-azanium 2'-[3-carboxamido-3-(trimethylammonio)propyl]-L-histidine 2-[(R)-3-carboxamido-3-(trimethylammonio)propyl]-4-((S)-2-amino-2-carboxyethyl)-1H-imidazole 2-[3-carboxamido-3-(trimethylammonio)propyl]histidine 2-amino-3-[[2-(3-amino-3-carbamoyl-prop-1-enyl)-1,1,3-trimethyl-2,3-dihydroimidazol-5-yl]]propanoic acid 2-amino-4-[[5-(2-amino-2-carboxylato-ethyl)-1,1,3-trimethyl-2,3-dihydroimidazol-2-yl]]but-3-enamide Diphth MOD_RES Diphthamide alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-1H-imidazole-2-propanaminium diphthamide diphthamide (from histidine) Diphthamide Diphthamide A protein modification that effectively converts an L-alanine residue to N-acetyl-L-alanine. 42.04 C 2 H 2 N 0 O 1 42.010567 C 5 H 8 N 1 O 2 114.12 114.055504 A natural N-term PTM-0199 (2S)-2-(acetamido)propanoic acid 2-(acetylamino)propanoic acid 2-(acetylazanyl)propanoic acid AcAla MOD_RES N-acetylalanine N-acetyl-L-alanine N-acetylated L-alanine acetylalanine PSI-MOD MOD:00050 N-acetyl-L-alanine A protein modification that effectively converts an L-alanine residue to N-acetyl-L-alanine. PubMed:363452 PubMed:4700463 RESID:AA0041 (2S)-2-(acetamido)propanoic acid 2-(acetylamino)propanoic acid 2-(acetylazanyl)propanoic acid AcAla MOD_RES N-acetylalanine N-acetyl-L-alanine N-acetylated L-alanine acetylalanine A protein modification that effectively converts an L-aspartic acid residue to N-acetyl-L-aspartic acid. 42.04 C 2 H 2 N 0 O 1 42.010567 C 6 H 8 N 1 O 4 158.13 158.04533 D natural N-term PTM-0200 (2S)-2-(acetamido)butanedioic acid 2-(acetylamino)butanedioic acid 2-(acetylazanyl)butanedioic acid AcAsp MOD_RES N-acetylaspartate N-acetyl-L-aspartic acid N-acetylated L-aspartic acid acetylaspartic acid PSI-MOD MOD:00051 N-acetyl-L-aspartic acid A protein modification that effectively converts an L-aspartic acid residue to N-acetyl-L-aspartic acid. ChEBI:21547 PubMed:1560020 PubMed:2395459 RESID:AA0042 (2S)-2-(acetamido)butanedioic acid 2-(acetylamino)butanedioic acid 2-(acetylazanyl)butanedioic acid AcAsp MOD_RES N-acetylaspartate N-acetyl-L-aspartic acid N-acetylated L-aspartic acid acetylaspartic acid A protein modification that effectively converts an L-cysteine residue to N-acetyl-L-cysteine. 42.04 C 2 H 2 N 0 O 1 S 0 42.010567 C 5 H 8 N 1 O 2 S 1 146.18 146.02757 C natural N-term PTM-0201 (2R)-2-acetamido-3-sulfanylpropanoic acid 2-acetylamino-3-mercaptopropanoic acid 2-acetylamino-3-sulfanylpropanoic acid 2-acetylazanyl-3-sulfanylpropanoic acid MOD_RES N-acetylcysteine N-acetyl-L-cysteine N-acetylated cysteine N-acetylcysteine NAcCys PSI-MOD Acetyl MOD:00052 incidental to RESID:AA0223 N-acetyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to N-acetyl-L-cysteine. ChEBI:28939 PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:1500421 PubMed:15350136 PubMed:6725286 RESID:AA0043 (2R)-2-acetamido-3-sulfanylpropanoic acid 2-acetylamino-3-mercaptopropanoic acid 2-acetylamino-3-sulfanylpropanoic acid 2-acetylazanyl-3-sulfanylpropanoic acid MOD_RES N-acetylcysteine N-acetyl-L-cysteine N-acetylated cysteine N-acetylcysteine NAcCys Acetyl A protein modification that effectively converts an L-glutamic acid residue to N-acetyl-L-glutamic acid. 42.04 C 2 H 2 N 0 O 1 42.010567 C 7 H 10 N 1 O 4 172.16 172.06099 E natural N-term PTM-0202 (2S)-2-(acetamido)pentanedioic acid 2-(acetylamino)pentanedioic acid 2-(acetylazanyl)pentanedioic acid AcGlu MOD_RES N-acetylglutamate N-acetyl-L-glutamic acid N-acetylated L-glutamic acid acetylglutamic acid PSI-MOD MOD:00053 N-acetyl-L-glutamic acid A protein modification that effectively converts an L-glutamic acid residue to N-acetyl-L-glutamic acid. ChEBI:17533 PubMed:6725286 RESID:AA0044 (2S)-2-(acetamido)pentanedioic acid 2-(acetylamino)pentanedioic acid 2-(acetylazanyl)pentanedioic acid AcGlu MOD_RES N-acetylglutamate N-acetyl-L-glutamic acid N-acetylated L-glutamic acid acetylglutamic acid A protein modification that effectively converts an L-glutamine residue to N-acetyl-L-glutamine. 42.04 C 2 H 2 N 0 O 1 42.010567 C 7 H 11 N 2 O 3 171.18 171.07697 Q artifact N-term (2S)-2-acetamido-5-pentanediamic acid 2-acetylamino-5-amino-5-oxopentanoic acid 2-acetylamino-5-pentanediamic acid 2-acetylazanyl-5-azanyl-5-oxopentanoic acid AcGln N-acetyl-L-glutamine N-acetylated L-glutamine acetylglutamine PSI-MOD MOD:00054 This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. N-acetyl-L-glutamine A protein modification that effectively converts an L-glutamine residue to N-acetyl-L-glutamine. RESID:AA0045 (2S)-2-acetamido-5-pentanediamic acid 2-acetylamino-5-amino-5-oxopentanoic acid 2-acetylamino-5-pentanediamic acid 2-acetylazanyl-5-azanyl-5-oxopentanoic acid AcGln N-acetyl-L-glutamine N-acetylated L-glutamine acetylglutamine A protein modification that effectively converts a glycine residue to N-acetylglycine. 42.04 C 2 H 2 N 0 O 1 42.010567 C 4 H 6 N 1 O 2 100.1 100.039856 G natural N-term PTM-0203 (acetylamino)acetic acid (acetylazanyl)ethanoic acid 2-(acetamido)ethanoic acid 2-(acetylamino)ethanoic acid AcGly MOD_RES N-acetylglycine N-acetylated glycine N-acetylglycine aceturic acid PSI-MOD MOD:00055 N-acetylglycine A protein modification that effectively converts a glycine residue to N-acetylglycine. PubMed:272676 PubMed:5545094 PubMed:6754709 RESID:AA0046 (acetylamino)acetic acid (acetylazanyl)ethanoic acid 2-(acetamido)ethanoic acid 2-(acetylamino)ethanoic acid AcGly MOD_RES N-acetylglycine N-acetylated glycine N-acetylglycine aceturic acid A protein modification that effectively converts an L-isoleucine residue to N-acetyl-L-isoleucine. 42.04 C 2 H 2 N 0 O 1 42.010567 C 8 H 14 N 1 O 2 156.2 156.10245 I artifact N-term PTM-0204 (2S,3S)-2-acetamido-3-methylpentanoic acid 2-acetylamino-3-methylpentanoic acid 2-acetylazanyl-3-methylpentanoic acid AcIle N-acetyl-L-isoleucine N-acetylated L-isoleucine acetylisoleucine PSI-MOD MOD:00056 This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. N-acetyl-L-isoleucine A protein modification that effectively converts an L-isoleucine residue to N-acetyl-L-isoleucine. PubMed:8034631 RESID:AA0047 (2S,3S)-2-acetamido-3-methylpentanoic acid 2-acetylamino-3-methylpentanoic acid 2-acetylazanyl-3-methylpentanoic acid AcIle N-acetyl-L-isoleucine N-acetylated L-isoleucine acetylisoleucine A protein modification that effectively converts an L-lysine residue to N2-acetyl-L-lysine. 42.04 C 2 H 2 N 0 O 1 42.010567 C 8 H 15 N 2 O 2 171.22 171.11336 K artifact N-term (2S)-2-acetamido-6-aminohexanoic acid 2-acetylamino-6-aminohexanoic acid 2-acetylazanyl-6-azanylhexanoic acid N2-acetyl-L-lysine N2-acetylated L-lysine N2-acetyllysine N2AcLys PSI-MOD Acetyl MOD:00057 This is a deprecated entry in RESID. It probably does not occur naturally [JSG]. N2-acetyl-L-lysine A protein modification that effectively converts an L-lysine residue to N2-acetyl-L-lysine. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 RESID:AA0048 (2S)-2-acetamido-6-aminohexanoic acid 2-acetylamino-6-aminohexanoic acid 2-acetylazanyl-6-azanylhexanoic acid N2-acetyl-L-lysine N2-acetylated L-lysine N2-acetyllysine N2AcLys Acetyl A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine. 42.04 C 2 H 2 N 0 O 1 S 0 42.010567 C 7 H 12 N 1 O 2 S 1 174.24 174.05887 M natural N-term PTM-0205 (2S)-2-acetamido-4-(methylsulfanyl)butanoic acid 2-acetylamino-4-(methylsulfanyl)butanoic acid 2-acetylamino-4-(methylthio)butanoic acid 2-acetylazanyl-4-(methylsulfanyl)butanoic acid AcMet MOD_RES N-acetylmethionine N-acetyl-L-methionine N-acetylated L-methionine acetylmethionine methionamine PSI-MOD MOD:00058 N-acetyl-L-methionine A protein modification that effectively converts an L-methionine to N-acetyl-L-methionine. PubMed:7944406 RESID:AA0049 (2S)-2-acetamido-4-(methylsulfanyl)butanoic acid 2-acetylamino-4-(methylsulfanyl)butanoic acid 2-acetylamino-4-(methylthio)butanoic acid 2-acetylazanyl-4-(methylsulfanyl)butanoic acid AcMet MOD_RES N-acetylmethionine N-acetyl-L-methionine N-acetylated L-methionine acetylmethionine methionamine A protein modification that effectively converts an L-proline residue to N-acetyl-L-proline. 42.04 C 2 H 2 N 0 O 1 42.010567 C 7 H 10 N 1 O 2 140.16 140.07115 P natural N-term PTM-0206 (2S)-1-acetyl-2-pyrrolidinecarboxylic acid 1-acetylproline MOD_RES N-acetylproline N-acetyl-L-proline N-acetylated L-proline N-acetylproline NAcPro acetylproline PSI-MOD MOD:00059 N-acetyl-L-proline A protein modification that effectively converts an L-proline residue to N-acetyl-L-proline. PubMed:2928307 RESID:AA0050 (2S)-1-acetyl-2-pyrrolidinecarboxylic acid 1-acetylproline MOD_RES N-acetylproline N-acetyl-L-proline N-acetylated L-proline N-acetylproline NAcPro acetylproline A protein modification that effectively converts an L-serine residue to N-acetyl-L-serine. 42.04 C 2 H 2 N 0 O 1 42.010567 C 5 H 8 N 1 O 3 130.12 130.05042 S natural N-term PTM-0207 (2S)-2-acetamido-3-hydroxypropanoic acid 2-acetylamino-3-hydroxypropanoic acid 2-acetylazanyl-3-hydroxypropanoic acid MOD_RES N-acetylserine N-acetyl-L-serine N-acetylated L-serine N-acetylserine NAcSer PSI-MOD Acetyl MOD:00060 N-acetyl-L-serine A protein modification that effectively converts an L-serine residue to N-acetyl-L-serine. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 PubMed:1880797 PubMed:2106685 PubMed:6997045 RESID:AA0051 (2S)-2-acetamido-3-hydroxypropanoic acid 2-acetylamino-3-hydroxypropanoic acid 2-acetylazanyl-3-hydroxypropanoic acid MOD_RES N-acetylserine N-acetyl-L-serine N-acetylated L-serine N-acetylserine NAcSer Acetyl A protein modification that effectively converts an L-threonine residue to N-acetyl-L-threonine. 42.04 C 2 H 2 N 0 O 1 42.010567 C 6 H 10 N 1 O 3 144.15 144.06607 T natural N-term PTM-0208 (2S,3R)-2-acetamido-3-hydroxybutanoic acid 2-acetylamino-3-hydroxybutanoic acid 2-acetylazanyl-3-hydroxybutanoic acid MOD_RES N-acetylthreonine N-acetyl-L-threonine N-acetylated L-threonine N-acetylthreonine N-methylcarbonylthreonine NAcThr PSI-MOD Acetyl Acetylation MOD:00061 N-acetyl-L-threonine A protein modification that effectively converts an L-threonine residue to N-acetyl-L-threonine. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 PubMed:2106685 PubMed:6997045 RESID:AA0052 (2S,3R)-2-acetamido-3-hydroxybutanoic acid 2-acetylamino-3-hydroxybutanoic acid 2-acetylazanyl-3-hydroxybutanoic acid MOD_RES N-acetylthreonine N-acetyl-L-threonine N-acetylated L-threonine N-acetylthreonine N-methylcarbonylthreonine NAcThr Acetyl Acetylation A protein modification that effectively converts an L-tyrosine residue to N-acetyl-L-tyrosine. 42.04 C 2 H 2 N 0 O 1 42.010567 C 11 H 12 N 1 O 3 206.22 206.08171 Y natural N-term PTM-0209 (2S)-2-acetamido-3-(4-hydoxyphenyl)propanoic acid 2-acetylamino-3-(4-hydoxyphenyl)propanoic acid 2-acetylazanyl-3-(4-hydoxyphenyl)propanoic acid AcTyr MOD_RES N-acetyltyrosine N-acetyl-L-tyrosine N-acetylated L-tyrosine N-acetyltyrosine PSI-MOD Acetyl MOD:00062 N-acetyl-L-tyrosine A protein modification that effectively converts an L-tyrosine residue to N-acetyl-L-tyrosine. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 PubMed:2506074 PubMed:475783 RESID:AA0053 (2S)-2-acetamido-3-(4-hydoxyphenyl)propanoic acid 2-acetylamino-3-(4-hydoxyphenyl)propanoic acid 2-acetylazanyl-3-(4-hydoxyphenyl)propanoic acid AcTyr MOD_RES N-acetyltyrosine N-acetyl-L-tyrosine N-acetylated L-tyrosine N-acetyltyrosine Acetyl A protein modification that effectively converts an L-valine residue to N-acetyl-L-valine. 42.04 C 2 H 2 N 0 O 1 42.010567 C 7 H 12 N 1 O 2 142.18 142.0868 V natural N-term PTM-0210 (2S)-2-acetamido-3-methylbutanoic acid 2-acetylamino-3-methylbutanoic acid 2-acetylazanyl-3-methylbutanoic acid AcVal MOD_RES N-acetylvaline N-acetyl-L-valine N-acetylated L-valine N-acetylvaline PSI-MOD MOD:00063 N-acetyl-L-valine A protein modification that effectively converts an L-valine residue to N-acetyl-L-valine. PubMed:1735421 RESID:AA0054 (2S)-2-acetamido-3-methylbutanoic acid 2-acetylamino-3-methylbutanoic acid 2-acetylazanyl-3-methylbutanoic acid AcVal MOD_RES N-acetylvaline N-acetyl-L-valine N-acetylated L-valine N-acetylvaline A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine. 42.04 C 2 H 2 N 0 O 1 42.010567 C 8 H 14 N 2 O 2 170.21 170.10553 K natural PTM-0190 Unimod:1 (2S)-6-acetamido-2-aminohexanoic acid 6-acetylamino-2-aminohexanoic acid 6-acetylazanyl-2-aminohexanoic acid MOD_RES N6-acetyllysine N(zeta)-acetyllysine N6-acetyl-L-lysine N6-acetylated L-lysine N6AcLys acetylk epsilon-acetyllysine PSI-MOD Acetyl Acetylation MOD:00064 N6-acetyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine. ChEBI:17752 DeltaMass:214 OMSSA:24 PubMed:11369851 PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:14730666 PubMed:15350136 PubMed:1680872 PubMed:670159 RESID:AA0055 Unimod:1#K (2S)-6-acetamido-2-aminohexanoic acid 6-acetylamino-2-aminohexanoic acid 6-acetylazanyl-2-aminohexanoic acid MOD_RES N6-acetyllysine N(zeta)-acetyllysine N6-acetyl-L-lysine N6-acetylated L-lysine N6AcLys acetylk epsilon-acetyllysine Acetyl Acetylation A protein modification that effectively converts an L-cysteine residue to S-acetyl-L-cysteine. 42.04 C 2 H 2 N 0 O 1 S 0 42.010567 C 5 H 7 N 1 O 2 S 1 145.18 145.01974 C natural Unimod:1 (2R)-3-acetylsulfanyl-2-aminopropanoic acid 2-amino-3-(acetylthio)propanoic acid 2-azanyl-3-(acetylsulfanyl)propanoic acid ACT_SITE S-acetylcysteine intermediate S-acetyl-L-cysteine S-acetylcysteine SAcCys cysteine acetate thioester PSI-MOD Acetyl Acetylation MOD:00065 S-acetyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-acetyl-L-cysteine. PubMed:11857757 PubMed:11999733 PubMed:12175151 PubMed:1310545 PubMed:14730666 PubMed:15350136 RESID:AA0056 Unimod:1#C (2R)-3-acetylsulfanyl-2-aminopropanoic acid 2-amino-3-(acetylthio)propanoic acid 2-azanyl-3-(acetylsulfanyl)propanoic acid ACT_SITE S-acetylcysteine intermediate S-acetyl-L-cysteine S-acetylcysteine SAcCys cysteine acetate thioester Acetyl Acetylation A protein modification that effectively converts a glycine residue to N-formylglycine. 28.01 C 1 H 0 N 0 O 1 27.994915 C 3 H 4 N 1 O 2 86.07 86.0242 G natural N-term PTM-0211 (formylamino)acetic acid (formylamino)ethanoic acid (formylazanyl)ethanoic acid 2-formamidoacetic acid 2-formamidoethanoic acid MOD_RES N-formylglycine N(alpha)-formylglycine N-formylated glycine N-formylglycine NFoGly PSI-MOD MOD:00066 N-formylglycine A protein modification that effectively converts a glycine residue to N-formylglycine. PubMed:5139483 RESID:AA0057 (formylamino)acetic acid (formylamino)ethanoic acid (formylazanyl)ethanoic acid 2-formamidoacetic acid 2-formamidoethanoic acid MOD_RES N-formylglycine N(alpha)-formylglycine N-formylated glycine N-formylglycine NFoGly A protein modification that effectively converts a glycine residue to N-D-glucuronoylglycine. 176.12 C 6 H 8 N 0 O 6 176.03209 C 8 H 12 N 1 O 7 234.18 234.06137 G natural N-term PTM-0331 2-(glucuronoylamino)ethanoic acid MOD_RES N-D-glucuronoyl glycine N-D-glucuronoyl-glycine N-D-glucuronyl-glycine NGlcAGly ntermpepglucuronylg PSI-MOD Glucuronyl MOD:00067 N-D-glucuronoylglycine A protein modification that effectively converts a glycine residue to N-D-glucuronoylglycine. OMSSA:50 PubMed:10858503 PubMed:12716131 PubMed:6493057 PubMed:7398618 RESID:AA0058 2-(glucuronoylamino)ethanoic acid MOD_RES N-D-glucuronoyl glycine N-D-glucuronoyl-glycine N-D-glucuronyl-glycine NGlcAGly ntermpepglucuronylg Glucuronyl A protein modification that effectively converts a glycine residue to N-myristoylglycine. 210.36 C 14 H 26 N 0 O 1 210.19836 C 16 H 30 N 1 O 2 268.42 268.22766 G natural N-term PTM-0221 Unimod:45 (tetradecanoylamino)ethanoic acid LIPID N-myristoyl glycine N-(1-oxotetradecyl)glycine N-(C14:0 aliphatic acyl)glycine N-myristoyl-glycine N-myristoylated glycine N-myristylglycine N-tetradecanoylglycine NMyrGly ntermpepmyristoylationg PSI-MOD Myristoyl Myristoylation MOD:00068 N-myristoylglycine A protein modification that effectively converts a glycine residue to N-myristoylglycine. OMSSA:80 PubMed:11955007 PubMed:11955008 PubMed:1326520 PubMed:1386601 PubMed:6436247 PubMed:7543369 RESID:AA0059 Unimod:45#G (tetradecanoylamino)ethanoic acid LIPID N-myristoyl glycine N-(1-oxotetradecyl)glycine N-(C14:0 aliphatic acyl)glycine N-myristoyl-glycine N-myristoylated glycine N-myristylglycine N-tetradecanoylglycine NMyrGly ntermpepmyristoylationg Myristoyl Myristoylation A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine. 238.41 C 16 H 30 N 0 O 1 S 0 238.22966 C 19 H 36 N 1 O 2 S 1 342.56 342.24667 C natural N-term PTM-0222 (2R)-2-hexadecanoylamino-3-sulfanylpropanoic acid 2-hexadecanamido-3-sulfanylpropanoic acid 2-hexadecanoylamino-3-mercaptopropanoic acid LIPID N-palmitoyl cysteine N-(1-oxahexadecyl)-L-cysteine N-hexadecanoylated L-cysteine N-palmitoyl-L-cysteine N-palmitoylated L-cysteine NPamCys PSI-MOD Palmitoyl Palmitoylation MOD:00069 incidental to RESID:AA0107 incidental to RESID:AA0309 N-palmitoyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-L-cysteine. PubMed:10896212 PubMed:4575979 PubMed:9056182 PubMed:9593755 RESID:AA0060 (2R)-2-hexadecanoylamino-3-sulfanylpropanoic acid 2-hexadecanamido-3-sulfanylpropanoic acid 2-hexadecanoylamino-3-mercaptopropanoic acid LIPID N-palmitoyl cysteine N-(1-oxahexadecyl)-L-cysteine N-hexadecanoylated L-cysteine N-palmitoyl-L-cysteine N-palmitoylated L-cysteine NPamCys Palmitoyl Palmitoylation A protein modification that effectively converts an L-alanine residue to N-methyl-L-alanine. 14.03 C 1 H 2 N 0 O 0 14.01565 C 4 H 7 N 1 O 1 85.11 85.052765 A natural N-term PTM-0214 (2S)-2-methylaminopropanoic acid 2-methylazanylpropanoic acid MOD_RES N-methylalanine N-methyl-L-alanine N-methylalanine N-methylated L-alanine NMe1Ala PSI-MOD Methyl Methylation MOD:00070 Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methyl-L-alanine A protein modification that effectively converts an L-alanine residue to N-methyl-L-alanine. ChEBI:17519 PubMed:323502 PubMed:337304 PubMed:7007074 RESID:AA0061 (2S)-2-methylaminopropanoic acid 2-methylazanylpropanoic acid MOD_RES N-methylalanine N-methyl-L-alanine N-methylalanine N-methylated L-alanine NMe1Ala Methyl Methylation A protein modification that effectively converts an L-alanine residue to N,N,N-trimethyl-L-alanine. 43.09 C 3 H 7 N 0 O 0 43.054226 1+ C 6 H 13 N 1 O 1 115.18 115.09917 A natural N-term PTM-0177 (1S)-1-carboxy-N,N,N-trimethylethanaminium (1S)-1-carboxy-N,N,N-trimethylethanazanium (2S)-2-(trimethylammonio)propanoic acid MOD_RES N,N,N-trimethylalanine N,N,N-trimethyl-L-alanine N,N,N-trimethylalanine cation N,N,N-trimethylalaninium N,N,N-trimethylated L-alanine N2Me3+Ala NMe3Ala PSI-MOD Trimethyl tri-Methylation MOD:00071 N,N,N-trimethyl-L-alanine A protein modification that effectively converts an L-alanine residue to N,N,N-trimethyl-L-alanine. PubMed:12590383 PubMed:332162 PubMed:3979397 PubMed:6778808 PubMed:7715456 RESID:AA0062 (1S)-1-carboxy-N,N,N-trimethylethanaminium (1S)-1-carboxy-N,N,N-trimethylethanazanium (2S)-2-(trimethylammonio)propanoic acid MOD_RES N,N,N-trimethylalanine N,N,N-trimethyl-L-alanine N,N,N-trimethylalanine cation N,N,N-trimethylalaninium N,N,N-trimethylated L-alanine N2Me3+Ala NMe3Ala Trimethyl tri-Methylation A protein modification that effectively converts a glycine residue to N-methylglycine. 14.03 C 1 H 2 N 0 O 0 14.01565 C 3 H 5 N 1 O 1 71.08 71.03712 G natural N-term PTM-0483 L-sarcosine MOD_RES N-methylglycine N-methylated glycine N-methylglycine NMe1Gly Sar Sarcosine Sarcosyl methylaminoacetic acid methylaminoethanoic acid PSI-MOD Methyl Methylation MOD:00072 DeltaMass also has an entry for the free amino acid. Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methylglycine A protein modification that effectively converts a glycine residue to N-methylglycine. ChEBI:15611 DeltaMass:0 PubMed:1593629 RESID:AA0063 L-sarcosine MOD_RES N-methylglycine N-methylated glycine N-methylglycine NMe1Gly Sar Sarcosine Sarcosyl methylaminoacetic acid methylaminoethanoic acid Methyl Methylation A protein modification that effectively converts an L-methionine residue to N-methyl-L-methionine. 14.03 C 1 H 2 N 0 O 0 S 0 14.01565 C 6 H 11 N 1 O 1 S 1 145.22 145.05614 M natural N-term PTM-0217 (2S)-2-methylamino-4-(methylsulfanyl)butanoic acid 2-methylamino-4-(methylthio)butanoic acid MOD_RES N-methylmethionine Methyl Methionyl N-methyl-L-methionine N-methylated L-methionine N-methylmethionine NMe1Met PSI-MOD Methyl Methylation MOD:00073 Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methyl-L-methionine A protein modification that effectively converts an L-methionine residue to N-methyl-L-methionine. DeltaMass:169 PubMed:323502 PubMed:3298225 RESID:AA0064 (2S)-2-methylamino-4-(methylsulfanyl)butanoic acid 2-methylamino-4-(methylthio)butanoic acid MOD_RES N-methylmethionine Methyl Methionyl N-methyl-L-methionine N-methylated L-methionine N-methylmethionine NMe1Met Methyl Methylation A protein modification that effectively converts an L-phenylalanine residue to N-methyl-L-phenylalanine. 14.03 C 1 H 2 N 0 O 0 14.01565 C 10 H 11 N 1 O 1 161.2 161.08406 F natural N-term PTM-0218 (2S)-2-methylamino-3-phenylpropanoic acid MOD_RES N-methylphenylalanine N-methyl-L-phenylalanine N-methylated L-phenylalanine N-methylphenylalanine NMe1Phe PSI-MOD Methyl Methylation MOD:00074 Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG]. N-methyl-L-phenylalanine A protein modification that effectively converts an L-phenylalanine residue to N-methyl-L-phenylalanine. PubMed:2577730 PubMed:413571 RESID:AA0065 (2S)-2-methylamino-3-phenylpropanoic acid MOD_RES N-methylphenylalanine N-methyl-L-phenylalanine N-methylated L-phenylalanine N-methylphenylalanine NMe1Phe Methyl Methylation A protein modification that effectively converts an L-proline residue to N,N-dimethyl-L-proline. 29.06 C 2 H 5 N 0 O 0 29.038576 1+ C 7 H 13 N 1 O 1 127.19 127.09917 P natural N-term PTM-0179 Unimod:529 (2S)-2-carboxy-1,1-dimethylpyrrolidinium 1,1-dimethyl-L-prolinium MOD_RES N,N-dimethylproline N,N-dimethyl-L-proline N,N-dimethyl-L-prolinium N,N-dimethylated L-proline NMe2Pro stachydrin PSI-MOD Delta:H(5)C(2) Dimethyl Dimethylation of proline residue MOD:00075 Unimod terminal specification corrected [JSG]. N,N-dimethyl-L-proline A protein modification that effectively converts an L-proline residue to N,N-dimethyl-L-proline. ChEBI:21451 PubMed:12964758 PubMed:14570711 PubMed:193025 PubMed:3882426 PubMed:6254758 RESID:AA0066 Unimod:529 (2S)-2-carboxy-1,1-dimethylpyrrolidinium 1,1-dimethyl-L-prolinium MOD_RES N,N-dimethylproline N,N-dimethyl-L-proline N,N-dimethyl-L-prolinium N,N-dimethylated L-proline NMe2Pro stachydrin Delta:H(5)C(2) Dimethyl Dimethylation of proline residue A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine. 28.05 C 2 H 4 N 0 O 0 28.0313 C 8 H 16 N 4 O 1 184.24 184.13242 R natural PTM-0287 Unimod:36 (2S)-2-amino-5-[((methylamino)(methylimino)methyl)amino]pentanoic acid MOD_RES Omega-N-methylated arginine MOD_RES Symmetric dimethylarginine N3,N4-dimethylarginine N5-[(methylamino)(methylimino)methyl]ornithine NG,N'G-dimethylarginine NoNo'Me2Arg omega-N,omega-N'-dimethyl-L-arginine omega-N,omega-N'-dimethylated L-arginine symmetric dimethylarginine PSI-MOD Dimethyl di-Methylation MOD:00076 symmetric dimethyl-L-arginine A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine. PubMed:12964758 PubMed:14570711 PubMed:15835918 PubMed:2426402 PubMed:5128665 RESID:AA0067 Unimod:36#R (2S)-2-amino-5-[((methylamino)(methylimino)methyl)amino]pentanoic acid MOD_RES Omega-N-methylated arginine MOD_RES Symmetric dimethylarginine N3,N4-dimethylarginine N5-[(methylamino)(methylimino)methyl]ornithine NG,N'G-dimethylarginine NoNo'Me2Arg omega-N,omega-N'-dimethyl-L-arginine omega-N,omega-N'-dimethylated L-arginine symmetric dimethylarginine Dimethyl di-Methylation A protein modification that effectively converts an L-arginine residue to asymmetric dimethylarginine, N(omega),N(omega)-dimethyl-L-arginine. 28.05 C 2 H 4 N 0 O 0 28.0313 C 8 H 16 N 4 O 1 184.24 184.13242 R natural PTM-0066 Unimod:36 (2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid MOD_RES Asymmetric dimethylarginine MOD_RES Omega-N-methylated arginine N5-[(dimethylamino)(imino)methyl]ornithine NG,NG-dimethylarginine NoNoMe2Arg asymmetric dimethylarginine omega-N,omega-N-dimethlyated L-arginine omega-N,omega-N-dimethyl-L-arginine PSI-MOD Dimethyl di-Methylation MOD:00077 asymmetric dimethyl-L-arginine A protein modification that effectively converts an L-arginine residue to asymmetric dimethylarginine, N(omega),N(omega)-dimethyl-L-arginine. ChEBI:17929 PubMed:11152131 PubMed:12964758 PubMed:14570711 PubMed:15835918 PubMed:3032834 RESID:AA0068 Unimod:36#R (2S)-2-amino-5-([(dimethylamino)(imino)methyl]amino)pentanoic acid MOD_RES Asymmetric dimethylarginine MOD_RES Omega-N-methylated arginine N5-[(dimethylamino)(imino)methyl]ornithine NG,NG-dimethylarginine NoNoMe2Arg asymmetric dimethylarginine omega-N,omega-N-dimethlyated L-arginine omega-N,omega-N-dimethyl-L-arginine Dimethyl di-Methylation A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine. 14.03 C 1 H 2 N 0 O 0 14.01565 C 7 H 14 N 4 O 1 170.22 170.11676 R natural PTM-0237 (2S)-2-amino-5-[(imino(methylamino)methyl)amino]pentanoic acid MOD_RES Omega-N-methylarginine MOD_RES Omega-N-methylated arginine NG-methylarginine NoMeArg omega-N-methyl-L-arginine omega-N-methylated L-arginine PSI-MOD Methyl Methylation MOD:00078 omega-N-methyl-L-arginine A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine. PubMed:11875433 PubMed:15835918 PubMed:2426402 PubMed:5128665 RESID:AA0069 (2S)-2-amino-5-[(imino(methylamino)methyl)amino]pentanoic acid MOD_RES Omega-N-methylarginine MOD_RES Omega-N-methylated arginine NG-methylarginine NoMeArg omega-N-methyl-L-arginine omega-N-methylated L-arginine Methyl Methylation A protein modification that effectively converts an L-asparagine residue to N4-methyl-L-asparagine. 14.03 C 1 H 2 N 0 O 0 14.01565 C 5 H 8 N 2 O 2 128.13 128.05858 N natural PTM-0183 Unimod:34 (2S)-2-amino-N4-methylbutanediamic acid MOD_RES N4-methylasparagine N(gamma)-methylasparagine N-methylasparagine N4-methyl-L-asparagine N4-methylated L-asparagine N4Me1Asn beta-aspartyl methylamide methyln PSI-MOD Methyl Methylation beta-methylasparagine MOD:00079 N4-methyl-L-asparagine A protein modification that effectively converts an L-asparagine residue to N4-methyl-L-asparagine. OMSSA:75 PubMed:11875433 PubMed:2356973 PubMed:3782095 RESID:AA0070 Unimod:34#N (2S)-2-amino-N4-methylbutanediamic acid MOD_RES N4-methylasparagine N(gamma)-methylasparagine N-methylasparagine N4-methyl-L-asparagine N4-methylated L-asparagine N4Me1Asn beta-aspartyl methylamide methyln Methyl Methylation beta-methylasparagine A protein modification that effectively converts an L-glutamine residue to N5-methyl-L-glutamine. 14.03 C 1 H 2 N 0 O 0 14.01565 C 6 H 10 N 2 O 2 142.16 142.07423 Q natural PTM-0185 (2S)-2-amino-5-methylamino-5-oxopentanoic acid 2-amino-N5-methylpentanediamic acid MOD_RES N5-methylglutamine N(delta)-methylglutamine N-methylglutamine N5-methyl-L-glutamine N5-methylated L-glutamine N5Me1Gln gamma-methylglutamine PSI-MOD Methyl Methylation MOD:00080 N5-methyl-L-glutamine A protein modification that effectively converts an L-glutamine residue to N5-methyl-L-glutamine. ChEBI:17592 DeltaMass:166 PubMed:11118225 PubMed:11875433 PubMed:365579 RESID:AA0071 (2S)-2-amino-5-methylamino-5-oxopentanoic acid 2-amino-N5-methylpentanediamic acid MOD_RES N5-methylglutamine N(delta)-methylglutamine N-methylglutamine N5-methyl-L-glutamine N5-methylated L-glutamine N5Me1Gln gamma-methylglutamine Methyl Methylation A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-methyl ester. 14.03 C 1 H 2 N 0 O 0 14.01565 C 6 H 9 N 1 O 3 143.14 143.05824 E natural PTM-0128 Unimod:34 (2S)-2-amino-5-methoxy-5-oxopentanoic acid (5)-methyl L-hydrogen glutamate 2-aminopentanedioic acid 5-methyl ester 5-methyl L-2-aminoglutarate 5-methyl L-glutamate 5-methyl esterified L-glutamic acid L-glutamic acid 5-methyl ester MOD_RES Glutamate methyl ester (Glu) O-methyl Glutamyl O5MeGlu glutamic acid 5-methyl ester glutamic acid gamma-methyl ester meestere methyle PSI-MOD Methyl Methylation methyl ester MOD:00081 DeltaMass gives the formula "C 6 H 9 O 1 N 3" with mass 143 (formula incorrect, N and O reversed) [JSG]. L-glutamic acid 5-methyl ester (Glu) A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-methyl ester. DeltaMass:167 OMSSA:17 OMSSA:70 PubMed:16888 PubMed:6300110 RESID:AA0072#GLU Unimod:34#E (2S)-2-amino-5-methoxy-5-oxopentanoic acid (5)-methyl L-hydrogen glutamate 2-aminopentanedioic acid 5-methyl ester 5-methyl L-2-aminoglutarate 5-methyl L-glutamate 5-methyl esterified L-glutamic acid L-glutamic acid 5-methyl ester MOD_RES Glutamate methyl ester (Glu) O-methyl Glutamyl O5MeGlu glutamic acid 5-methyl ester glutamic acid gamma-methyl ester meestere methyle Methyl Methylation methyl ester A protein modification that effectively converts an L-histidine residue to pros-methyl-L-histidine (N-pi-methyl-L-histidine, 3'-methyl-L-histidine). 14.03 C 1 H 2 N 0 O 0 14.01565 C 7 H 9 N 3 O 1 151.17 151.07455 H natural PTM-0259 (2S)-2-amino-3-(3-methyl-3H-imidazol-4-yl)propanoic acid 3'-methyl-L-histidine MOD_RES Pros-methylhistidine N(delta)-methylhistidine N(pi)-methylhistidine NpMeHis pros-methylated L-histidine pros-methylhistidine PSI-MOD 1-methylhistidine Methyl Methylation MOD:00082 3'-methyl-L-histidine A protein modification that effectively converts an L-histidine residue to pros-methyl-L-histidine (N-pi-methyl-L-histidine, 3'-methyl-L-histidine). PubMed:10660523 PubMed:11875433 PubMed:3467365 PubMed:6692818 PubMed:8076 PubMed:8645219 RESID:AA0073 (2S)-2-amino-3-(3-methyl-3H-imidazol-4-yl)propanoic acid 3'-methyl-L-histidine MOD_RES Pros-methylhistidine N(delta)-methylhistidine N(pi)-methylhistidine NpMeHis pros-methylated L-histidine pros-methylhistidine 1-methylhistidine Methyl Methylation A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine. 43.09 C 3 H 7 N 0 O 0 43.054226 1+ C 9 H 19 N 2 O 1 171.26 171.14919 K natural PTM-0187 (5S)-5-amino-5-carboxy-N,N,N-trimethylpentan-1-aminium 2-amino-6-(trimethylammonio)hexanoic acid 5-azanyl-5-carboxy-N,N,N-trimethylpentanazanium MOD_RES N6,N6,N6-trimethyllysine N(zeta)-trimethyllysine N-trimethylation (of lysine) N6,N6,N6-trimethyl-L-lysine N6,N6,N6-trimethylated L-lysine N6,N6,N6-trimethyllysin-N6-ium N6,N6,N6-trimethyllysine cation N6Me3+Lys epsilon-trimethyllysine PSI-MOD Trimethyl tri-Methylation MOD:00083 DeltaMass calculates the mass difference from protonated lysine rather than neutral lysine; for trimethylated lysine starting from protonated lysine see MOD:00855 N6,N6,N6-trimethyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine. ChEBI:17311 PubMed:12590383 PubMed:3145979 PubMed:4304194 PubMed:6778808 PubMed:7093227 PubMed:8453381 RESID:AA0074 (5S)-5-amino-5-carboxy-N,N,N-trimethylpentan-1-aminium 2-amino-6-(trimethylammonio)hexanoic acid 5-azanyl-5-carboxy-N,N,N-trimethylpentanazanium MOD_RES N6,N6,N6-trimethyllysine N(zeta)-trimethyllysine N-trimethylation (of lysine) N6,N6,N6-trimethyl-L-lysine N6,N6,N6-trimethylated L-lysine N6,N6,N6-trimethyllysin-N6-ium N6,N6,N6-trimethyllysine cation N6Me3+Lys epsilon-trimethyllysine Trimethyl tri-Methylation A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine. 28.05 C 2 H 4 N 0 O 0 28.0313 C 8 H 16 N 2 O 1 156.23 156.12627 K natural PTM-0188 Unimod:36 (2S)-2-amino-6-(dimethylamino)hexanoic acid MOD_RES N6,N6-dimethyllysine N(zeta)-dimethyllysine N6,N6-dimethyl-L-lysine N6,N6-dimethylated L-lysine N6Me2Lys dimethylk epsilon-dimethyllysine lysine derivative Lys(y) PSI-MOD Dimethyl di-Methylation MOD:00084 N6,N6-dimethyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6,N6-dimethyl-L-lysine. OMSSA:36 PubMed:10550045 PubMed:12964758 PubMed:14570711 PubMed:3100523 PubMed:8453381 RESID:AA0075 Unimod:36#K (2S)-2-amino-6-(dimethylamino)hexanoic acid MOD_RES N6,N6-dimethyllysine N(zeta)-dimethyllysine N6,N6-dimethyl-L-lysine N6,N6-dimethylated L-lysine N6Me2Lys dimethylk epsilon-dimethyllysine lysine derivative Lys(y) Dimethyl di-Methylation A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine. 14.03 C 1 H 2 N 0 O 0 14.01565 C 7 H 14 N 2 O 1 142.2 142.11061 K natural PTM-0194 Unimod:34 (2S)-2-amino-6-methylaminohexanoic acid MOD_RES N6-methyllysine N(zeta)-methyllysine N-methyl Lysyl N6-methyl-L-lysine N6-methylated L-lysine N6Me1Lys epsilon-methyllysine PSI-MOD Methyl Methylation MOD:00085 N6-methyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-methyl-L-lysine. ChEBI:17604 DeltaMass:165 PubMed:11875433 PubMed:3926756 RESID:AA0076 Unimod:34#K (2S)-2-amino-6-methylaminohexanoic acid MOD_RES N6-methyllysine N(zeta)-methyllysine N-methyl Lysyl N6-methyl-L-lysine N6-methylated L-lysine N6Me1Lys epsilon-methyllysine Methyl Methylation A protein modification that effectively converts an L-lysine residue to N6-palmitoyl-L-lysine. 238.41 C 16 H 30 N 0 O 1 238.22966 C 22 H 42 N 2 O 2 366.59 366.32462 K natural PTM-0197 Unimod:47 (2S)-2-amino-6-(hexadecanoylamino)hexanoic acid 2-amino-6-(hexadecanamido)hexanoic acid LIPID N6-palmitoyl lysine N(zeta)-palmitoyllysine N6-(1-oxohexadecyl)-L-lysine N6-hexadecanoylated L-lysine N6-palmitoyl-L-lysine N6-palmitoylated L-lysine N6PamLys epsilon-palmitoyllysine palmitoylationk PSI-MOD Palmitoyl Palmitoylation MOD:00086 N6-palmitoyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-palmitoyl-L-lysine. OMSSA:93 PubMed:2498336 PubMed:7801126 PubMed:7939682 RESID:AA0077 Unimod:47#K (2S)-2-amino-6-(hexadecanoylamino)hexanoic acid 2-amino-6-(hexadecanamido)hexanoic acid LIPID N6-palmitoyl lysine N(zeta)-palmitoyllysine N6-(1-oxohexadecyl)-L-lysine N6-hexadecanoylated L-lysine N6-palmitoyl-L-lysine N6-palmitoylated L-lysine N6PamLys epsilon-palmitoyllysine palmitoylationk Palmitoyl Palmitoylation A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine. 210.36 C 14 H 26 N 0 O 1 210.19836 C 20 H 38 N 2 O 2 338.54 338.29333 K natural PTM-0196 Unimod:45 (2S)-2-amino-6-(tetradecanoylamino)hexanoic acid 2-amino-6-(tetradecanamido)hexanoic acid LIPID N6-myristoyl lysine N(zeta)-myristoyllysine N6-(1-oxotetradecyl)-L-lysine N6-(C14:0 aliphatic acyl)lysine N6-myristoyl-L-lysine N6-myristoylated L-lysine N6MyrLys epsilon-myristoyllysine myristoylationk PSI-MOD Myristoyl Myristoylation MOD:00087 N6-myristoyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-myristoyl-L-lysine. OMSSA:81 PubMed:1402651 PubMed:8346241 RESID:AA0078 Unimod:45#K (2S)-2-amino-6-(tetradecanoylamino)hexanoic acid 2-amino-6-(tetradecanamido)hexanoic acid LIPID N6-myristoyl lysine N(zeta)-myristoyllysine N6-(1-oxotetradecyl)-L-lysine N6-(C14:0 aliphatic acyl)lysine N6-myristoyl-L-lysine N6-myristoylated L-lysine N6MyrLys epsilon-myristoyllysine myristoylationk Myristoyl Myristoylation A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine. 238.41 C 16 H 30 N 0 O 1 238.22966 C 20 H 37 N 1 O 3 339.52 339.27734 T natural PTM-0242 Unimod:47 (2S,3R)-2-amino-3-(hexadecanoyloxy)butanoic acid L-threonine hexadecanoate ester LIPID O-palmitoyl threonine O-hexadecanoylated L-threonine O-palmitoyl-L-threonine O-palmitoylated L-threonine O3-palmitoyl-threonine OPamThr palmitoylationt threonine palmitate ester PSI-MOD Palmitoyl Palmitoylation MOD:00088 O-palmitoyl-L-threonine A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine. OMSSA:95 PubMed:6642431 PubMed:8413602 RESID:AA0079 Unimod:47#T (2S,3R)-2-amino-3-(hexadecanoyloxy)butanoic acid L-threonine hexadecanoate ester LIPID O-palmitoyl threonine O-hexadecanoylated L-threonine O-palmitoyl-L-threonine O-palmitoylated L-threonine O3-palmitoyl-threonine OPamThr palmitoylationt threonine palmitate ester Palmitoyl Palmitoylation A protein modification that effectively converts an L-serine residue to O-palmitoyl-L-serine. 238.41 C 16 H 30 N 0 O 1 238.22966 C 19 H 35 N 1 O 3 325.49 325.2617 S natural PTM-0241 Unimod:47 (2S)-2-amino-3-(hexadecanoyloxy)propanoic acid ACT_SITE O-palmitoyl serine intermediate L-serine hexadecanoate ester LIPID O-palmitoyl serine O-hexadecanoylated L-serine O-palmitoyl-L-serine O-palmitoylated L-serine O3-palmitoyl-serine OPamSer palmitoylations serine palmitate ester PSI-MOD Palmitoyl Palmitoylation MOD:00089 O-palmitoyl-L-serine A protein modification that effectively converts an L-serine residue to O-palmitoyl-L-serine. OMSSA:94 PubMed:3467339 RESID:AA0080 Unimod:47#S (2S)-2-amino-3-(hexadecanoyloxy)propanoic acid ACT_SITE O-palmitoyl serine intermediate L-serine hexadecanoate ester LIPID O-palmitoyl serine O-hexadecanoylated L-serine O-palmitoyl-L-serine O-palmitoylated L-serine O3-palmitoyl-serine OPamSer palmitoylations serine palmitate ester Palmitoyl Palmitoylation A protein modification that effectively converts an L-alanine residue to L-alanine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 3 H 7 N 2 O 1 87.1 87.05584 A natural C-term PTM-0057 (2S)-2-aminopropanamide AlaN L-alanine amide MOD_RES Alanine amide alaninamide amidated L-alanine PSI-MOD MOD:00090 L-alanine amide A protein modification that effectively converts an L-alanine residue to L-alanine amide. PubMed:1377792 PubMed:2069951 PubMed:8472537 PubMed:952951 RESID:AA0081 (2S)-2-aminopropanamide AlaN L-alanine amide MOD_RES Alanine amide alaninamide amidated L-alanine A protein modification that effectively converts an L-arginine residue to L-arginine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 6 H 14 N 5 O 1 172.21 172.11984 R natural C-term PTM-0060 (2S)-2-amino-5-[(diaminomethylidene)amino]pentanamide 2-amino-5-carbamimidamidopentanamide 2-amino-5-guanidinopentanamide ArgN L-arginine amide MOD_RES Arginine amide amidated L-arginine argininamide PSI-MOD MOD:00091 L-arginine amide A protein modification that effectively converts an L-arginine residue to L-arginine amide. ChEBI:145897 PubMed:2229025 PubMed:2753890 PubMed:743209 RESID:AA0082 (2S)-2-amino-5-[(diaminomethylidene)amino]pentanamide 2-amino-5-carbamimidamidopentanamide 2-amino-5-guanidinopentanamide ArgN L-arginine amide MOD_RES Arginine amide amidated L-arginine argininamide A protein modification that effectively converts an L-asparagine residue to L-asparagine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 4 H 8 N 3 O 2 130.13 130.06165 N natural C-term PTM-0062 (2S)-2-aminobutanediamide AsnN L-asparagine amide MOD_RES Asparagine amide amidated L-asparagine asparaginamide PSI-MOD MOD:00092 L-asparagine amide A protein modification that effectively converts an L-asparagine residue to L-asparagine amide. ChEBI:145898 PubMed:2753132 PubMed:279902 PubMed:3415690 RESID:AA0083 (2S)-2-aminobutanediamide AsnN L-asparagine amide MOD_RES Asparagine amide amidated L-asparagine asparaginamide A protein modification that effectively converts an L-aspartic acid residue to L-aspartic acid 1-amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 4 H 7 N 2 O 3 131.11 131.04567 D natural C-term PTM-0063 (2S)-2-amino-1-butanediamic acid 1-amidated L-aspartic acid 3,4-diamino-4-oxobutanoic acid 3-amino-succinamic acid AspN L-aspartic acid 1-amide MOD_RES Aspartic acid 1-amide alpha-asparagine isoasparagine PSI-MOD MOD:00093 L-aspartic acid 1-amide A protein modification that effectively converts an L-aspartic acid residue to L-aspartic acid 1-amide. PubMed:2542051 RESID:AA0084 (2S)-2-amino-1-butanediamic acid 1-amidated L-aspartic acid 3,4-diamino-4-oxobutanoic acid 3-amino-succinamic acid AspN L-aspartic acid 1-amide MOD_RES Aspartic acid 1-amide alpha-asparagine isoasparagine A protein modification that effectively converts an L-cysteine residue to L-cysteine amide. -0.98 C 0 H 1 N 1 O -1 S 0 -0.984016 C 3 H 7 N 2 O 1 S 1 119.16 119.02791 C natural C-term PTM-0102 (2R)-2-amino-3-sulfanylpropanamide 2-amino-3-mercaptopropanamide CysN L-cysteine amide MOD_RES Cysteine amide amidated L-cysteine cysteinamide PSI-MOD MOD:00094 L-cysteine amide A protein modification that effectively converts an L-cysteine residue to L-cysteine amide. PubMed:1892838 PubMed:7149738 RESID:AA0085 (2R)-2-amino-3-sulfanylpropanamide 2-amino-3-mercaptopropanamide CysN L-cysteine amide MOD_RES Cysteine amide amidated L-cysteine cysteinamide A protein modification that effectively converts an L-glutamine residue to L-glutamine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 5 H 10 N 3 O 2 144.15 144.0773 Q natural C-term PTM-0130 (2S)-2-aminopentanediamide GlnN L-glutamine amide MOD_RES Glutamine amide amidated L-glutamine glutaminamide PSI-MOD MOD:00095 L-glutamine amide A protein modification that effectively converts an L-glutamine residue to L-glutamine amide. PubMed:7673220 PubMed:9048550 RESID:AA0086 (2S)-2-aminopentanediamide GlnN L-glutamine amide MOD_RES Glutamine amide amidated L-glutamine glutaminamide A protein modification that effectively converts an L-glutamic acid residue to L-glutamic acid 1-amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 5 H 9 N 2 O 3 145.14 145.06131 E natural C-term PTM-0129 (2S)-2-amino-1-pentanediamic acid 1-amidated L-glutamic acid 4,5-diamino-5-oxopentanoic acid GluN L-glutamic acid 1-amide MOD_RES Glutamic acid 1-amide isoglutamine PSI-MOD MOD:00096 L-glutamic acid 1-amide A protein modification that effectively converts an L-glutamic acid residue to L-glutamic acid 1-amide. PubMed:1093875 PubMed:14550575 RESID:AA0087 (2S)-2-amino-1-pentanediamic acid 1-amidated L-glutamic acid 4,5-diamino-5-oxopentanoic acid GluN L-glutamic acid 1-amide MOD_RES Glutamic acid 1-amide isoglutamine A protein modification that effectively converts a glycine residue to glycine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 2 H 5 N 2 O 1 73.07 73.04019 G natural C-term PTM-0132 2-aminoacetamide 2-aminoethanamide 2-azanylethanamide GlyN MOD_RES Glycine amide amidated glycine glycinamide glycine amide PSI-MOD MOD:00097 glycine amide A protein modification that effectively converts a glycine residue to glycine amide. PubMed:13591312 RESID:AA0088 2-aminoacetamide 2-aminoethanamide 2-azanylethanamide GlyN MOD_RES Glycine amide amidated glycine glycinamide glycine amide A protein modification that effectively converts an L-histidine residue to L-histidine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 6 H 9 N 4 O 1 153.16 153.07764 H natural C-term PTM-0148 (2S)-2-amino-3-(1H-imidazol-4-yl)propanamide HisN L-histidine amide MOD_RES Histidine amide amidated L-histidine histidinamide PSI-MOD MOD:00098 L-histidine amide A protein modification that effectively converts an L-histidine residue to L-histidine amide. PubMed:2153586 PubMed:2307683 PubMed:2839478 RESID:AA0089 (2S)-2-amino-3-(1H-imidazol-4-yl)propanamide HisN L-histidine amide MOD_RES Histidine amide amidated L-histidine histidinamide A protein modification that effectively converts an L-isoleucine residue to L-isoleucine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 6 H 13 N 2 O 1 129.18 129.10278 I natural C-term PTM-0161 (2S,3S)-2-amino-3-methylpentanamide IleN L-isoleucine amide MOD_RES Isoleucine amide amidated L-isoleucine isoleucinamide PSI-MOD MOD:00099 L-isoleucine amide A protein modification that effectively converts an L-isoleucine residue to L-isoleucine amide. RESID:AA0090 (2S,3S)-2-amino-3-methylpentanamide IleN L-isoleucine amide MOD_RES Isoleucine amide amidated L-isoleucine isoleucinamide A protein modification that effectively converts an L-leucine residue to L-leucine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 6 H 13 N 2 O 1 129.18 129.10278 L natural C-term PTM-0166 (2S)-2-amino-4-methylpentanamide 2-amino-4-methylvaleramide 2-azanyl-4-methylpentanamide L-leucine amide LeuN MOD_RES Leucine amide alpha-aminoisocaproamide amidated L-leucine leucinamide PSI-MOD MOD:00100 L-leucine amide A protein modification that effectively converts an L-leucine residue to L-leucine amide. PubMed:2578459 RESID:AA0091 (2S)-2-amino-4-methylpentanamide 2-amino-4-methylvaleramide 2-azanyl-4-methylpentanamide L-leucine amide LeuN MOD_RES Leucine amide alpha-aminoisocaproamide amidated L-leucine leucinamide A protein modification that effectively converts an L-lysine residue to L-lysine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 6 H 14 N 3 O 1 144.2 144.1137 K natural C-term PTM-0168 (2S)-2,6-diaminohexanamide L-lysine amide LysN MOD_RES Lysine amide amidated L-lysine lysinamide PSI-MOD MOD:00101 L-lysine amide A protein modification that effectively converts an L-lysine residue to L-lysine amide. PubMed:6579533 RESID:AA0092 (2S)-2,6-diaminohexanamide L-lysine amide LysN MOD_RES Lysine amide amidated L-lysine lysinamide A protein modification that effectively converts an L-methionine residue to L-methionine amide. -0.98 C 0 H 1 N 1 O -1 S 0 -0.984016 C 5 H 11 N 2 O 1 S 1 147.22 147.0592 M natural C-term PTM-0164 (2S)-2-amino-4-(methylsulfanyl)butanamide 2-amino-4-(methylthio)butanamide L-methionine amide MOD_RES Methionine amide MetN amidated L-methionine methioninamide PSI-MOD MOD:00102 L-methionine amide methioninamide A protein modification that effectively converts an L-methionine residue to L-methionine amide. PubMed:4375977 RESID:AA0093 (2S)-2-amino-4-(methylsulfanyl)butanamide 2-amino-4-(methylthio)butanamide L-methionine amide MOD_RES Methionine amide MetN amidated L-methionine A protein modification that effectively converts an L-phenylalanine residue to L-phenylalanine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 9 H 11 N 2 O 1 163.2 163.08714 F natural C-term PTM-0248 (2S)-2-amino-3-phenylpropanamide L-phenylalanine amide MOD_RES Phenylalanine amide PheN amidated L-phenylalanine phenylalaninamide PSI-MOD MOD:00103 L-phenylalanine amide A protein modification that effectively converts an L-phenylalanine residue to L-phenylalanine amide. PubMed:2905621 PubMed:8868490 RESID:AA0094 (2S)-2-amino-3-phenylpropanamide L-phenylalanine amide MOD_RES Phenylalanine amide PheN amidated L-phenylalanine phenylalaninamide A protein modification that effectively converts an L-proline residue to L-proline amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 5 H 9 N 2 O 1 113.14 113.07149 P natural C-term PTM-0257 (2S)-pyrrolidine-2-carboxamide L-proline amide MOD_RES Proline amide ProN amidated L-proline prolinamide PSI-MOD MOD:00104 L-proline amide A protein modification that effectively converts an L-proline residue to L-proline amide. PubMed:4982117 PubMed:5760861 RESID:AA0095 (2S)-pyrrolidine-2-carboxamide L-proline amide MOD_RES Proline amide ProN amidated L-proline prolinamide A protein modification that effectively converts an L-serine residue to L-serine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 3 H 7 N 2 O 2 103.1 103.05075 S natural C-term PTM-0275 (2S)-2-amino-3-hydroxypropanamide L-serine amide MOD_RES Serine amide SerN amidated L-serine serinamide PSI-MOD MOD:00105 L-serine amide A protein modification that effectively converts an L-serine residue to L-serine amide. PubMed:743209 RESID:AA0096 (2S)-2-amino-3-hydroxypropanamide L-serine amide MOD_RES Serine amide SerN amidated L-serine serinamide A protein modification that effectively converts an L-threonine residue to L-threonine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 4 H 9 N 2 O 2 117.13 117.06641 T natural C-term PTM-0293 (2S,3R)-2-amino-3-hydroxybutanamide L-threonine amide MOD_RES Threonine amide ThrN amidated L-threonine threoninamide PSI-MOD MOD:00106 L-threonine amide A protein modification that effectively converts an L-threonine residue to L-threonine amide. PubMed:1390774 RESID:AA0097 (2S,3R)-2-amino-3-hydroxybutanamide L-threonine amide MOD_RES Threonine amide ThrN amidated L-threonine threoninamide A protein modification that effectively converts an L-tryptophan residue to L-tryptophan amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 11 H 12 N 3 O 1 202.24 202.09804 W natural C-term PTM-0296 (2S)-2-amino-3-(1H-indol-3-yl)propanamide L-tryptophan amide MOD_RES Tryptophan amide TrpN amidated L-tryptophan tryptophanamide PSI-MOD MOD:00107 L-tryptophan amide A protein modification that effectively converts an L-tryptophan residue to L-tryptophan amide. PubMed:3947348 RESID:AA0098 (2S)-2-amino-3-(1H-indol-3-yl)propanamide L-tryptophan amide MOD_RES Tryptophan amide TrpN amidated L-tryptophan tryptophanamide A protein modification that effectively converts an L-tyrosine residue to L-tyrosine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 9 H 11 N 2 O 2 179.2 179.08205 Y natural C-term PTM-0302 (2S)-2-amino-3-(4-hydoxyphenyl)propanamide L-tyrosine amide MOD_RES Tyrosine amide TyrN amidated L-tyrosine tyrosinamide PSI-MOD MOD:00108 L-tyrosine amide A protein modification that effectively converts an L-tyrosine residue to L-tyrosine amide. PubMed:1377792 PubMed:3562898 PubMed:6509012 RESID:AA0099 (2S)-2-amino-3-(4-hydoxyphenyl)propanamide L-tyrosine amide MOD_RES Tyrosine amide TyrN amidated L-tyrosine tyrosinamide A protein modification that effectively converts an L-valine residue to L-valine amide. -0.98 C 0 H 1 N 1 O -1 -0.984016 C 5 H 11 N 2 O 1 115.16 115.087135 V natural C-term PTM-0303 (2S)-2-amino-3-methylbutanamide L-valine amide MOD_RES Valine amide ValN valinamide PSI-MOD MOD:00109 L-valine amide A protein modification that effectively converts an L-valine residue to L-valine amide. PubMed:2578459 PubMed:5465996 RESID:AA0100 (2S)-2-amino-3-methylbutanamide L-valine amide MOD_RES Valine amide ValN valinamide A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl disulfide. 46.09 C 1 H 2 N 0 O 0 S 1 45.98772 C 4 H 7 N 1 O 1 S 2 149.23 148.9969 C natural PTM-0104 Unimod:39 (2R)-2-amino-3-(methyldisulfanediyl)propanoic acid 2-amino-3-(methyldisulfanediyl)propanoic acid 2-amino-3-(methyldithio)propanoic acid 2-amino-3-methyldisulfanylpropanoic acid 2-azanyl-3-(methyldisulfanediyl)-propanoic acid L-3-(methyldithio)alanine L-cysteine methyl disulfide MOD_RES Cysteine methyl disulfide S-methylthio-L-cysteine S-methylthiocysteine methyl methanethiolsulfonate derivatized cysteine methyl methanethiosulfonate derivatized cysteine mmts PSI-MOD Beta-methylthiolation Methylthio MOD:00110 Produced artifactually by reaction of cysteine residues with methyl methanethiosulfonate (MMTS) [JSG], but also naturally in bacteria [PMT]. L-cysteine methyl disulfide A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl disulfide. OMSSA:179 PubMed:10555576 PubMed:163643 PubMed:2056535 PubMed:6381494 RESID:AA0101 Unimod:39#C (2R)-2-amino-3-(methyldisulfanediyl)propanoic acid 2-amino-3-(methyldisulfanediyl)propanoic acid 2-amino-3-(methyldithio)propanoic acid 2-amino-3-methyldisulfanylpropanoic acid 2-azanyl-3-(methyldisulfanediyl)-propanoic acid L-3-(methyldithio)alanine L-cysteine methyl disulfide MOD_RES Cysteine methyl disulfide S-methylthio-L-cysteine S-methylthiocysteine methyl methanethiolsulfonate derivatized cysteine methyl methanethiosulfonate derivatized cysteine mmts Beta-methylthiolation Methylthio Methylthio A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine. 204.36 C 15 H 24 N 0 O 0 S 0 204.1878 C 18 H 29 N 1 O 1 S 1 307.5 307.197 C natural PTM-0277 Unimod:44 (2R)-2-amino-3-([(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(3,7,11-trimethyl-2,6,10-dodecatrienylthio)propanoic acid LIPID S-farnesyl cysteine S-farnesyl Cystenyl S-farnesyl-L-cysteine SFarnCys farnesylationc PSI-MOD Farnesyl Farnesylation MOD:00111 From DeltaMass: (name misspelled "S-farnesyl cystenyl") S-farnesyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine. DeltaMass:293 OMSSA:42 PubMed:1409665 PubMed:15609361 PubMed:1872463 PubMed:2684976 RESID:AA0102 Unimod:44#C (2R)-2-amino-3-([(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(3,7,11-trimethyl-2,6,10-dodecatrienylthio)propanoic acid LIPID S-farnesyl cysteine S-farnesyl Cystenyl S-farnesyl-L-cysteine SFarnCys farnesylationc Farnesyl Farnesylation A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine. 220.36 C 15 H 24 N 0 O 1 S 0 220.18271 C 18 H 29 N 1 O 2 S 1 323.5 323.1919 C natural PTM-0269 Unimod:376 (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(12-hydroxy-3,7,11-trimethyl-3,6,10-dodecatrienylthio)propanoic acid LIPID S-12-hydroxyfarnesyl cysteine S-12-hydroxyfarnesyl-L-cysteine S12HyFarnCys PSI-MOD Hydroxyfarnesyl hydroxyfarnesyl MOD:00112 S-12-hydroxyfarnesyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine. PubMed:17790543 RESID:AA0103 Unimod:376 (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(12-hydroxy-3,7,11-trimethyl-3,6,10-dodecatrienylthio)propanoic acid LIPID S-12-hydroxyfarnesyl cysteine S-12-hydroxyfarnesyl-L-cysteine S12HyFarnCys Hydroxyfarnesyl hydroxyfarnesyl A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine. 272.48 C 20 H 32 N 0 O 0 S 0 272.2504 C 23 H 37 N 1 O 1 S 1 375.62 375.25958 C natural PTM-0278 Unimod:48 (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenylthio)propanoic acid LIPID S-geranylgeranyl cysteine S-geranylgeranyl S-geranylgeranyl-L-cysteine SGergerCys geranylgeranylc PSI-MOD Geranyl-geranyl GeranylGeranyl MOD:00113 DeltaMass calculates the mass with two double bonds rather than four S-geranylgeranyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine. DeltaMass:0 OMSSA:49 PubMed:1483450 PubMed:15609361 RESID:AA0104 Unimod:48#C (2R)-2-amino-3-([(2E,6E,10Z)-12-hydroxy-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]sulfanyl)propanoic acid 2-amino-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenylthio)propanoic acid LIPID S-geranylgeranyl cysteine S-geranylgeranyl S-geranylgeranyl-L-cysteine SGergerCys geranylgeranylc Geranyl-geranyl GeranylGeranyl A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl ester. 14.03 C 1 H 2 N 0 O 0 S 0 14.01565 C 4 H 8 N 1 O 2 S 1 134.17 134.02757 C natural C-term PTM-0105 Unimod:34 2-amino-3-mercaptopropanoic methyl ester 2-amino-3-sulfanylpropanoic methyl ester L-cysteine methyl ester MOD_RES Cysteine methyl ester OMeCys mecysteine methyl (2R)-2-amino-3-sulfanylpropanoate methyl L-cysteinate methyl esterified L-cysteine PSI-MOD Methyl Methylation MOD:00114 Secondary to RESID:AA0102; secondary to RESID:AA0103; secondary to RESID:AA0104. L-cysteine methyl ester A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl ester. PubMed:11875433 PubMed:1872463 RESID:AA0105 Unimod:34#C-term 2-amino-3-mercaptopropanoic methyl ester 2-amino-3-sulfanylpropanoic methyl ester L-cysteine methyl ester MOD_RES Cysteine methyl ester OMeCys mecysteine methyl (2R)-2-amino-3-sulfanylpropanoate methyl L-cysteinate methyl esterified L-cysteine Methyl Methylation A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine. 238.41 C 16 H 30 N 0 O 1 S 0 238.22966 C 19 H 35 N 1 O 2 S 1 341.55 341.23886 C natural PTM-0281 Unimod:47 (2R)-2-amino-3-(hexadecanoylsulfanyl)propanoic acid 2-amino-3-(hexadecanoylthio)propanoic acid ACT_SITE S-palmitoyl cysteine intermediate LIPID S-palmitoyl cysteine S-hexadecanoylated L-cysteine S-palmitoyl-L-cysteine S-palmitoylated L-cysteine S-palmityl Cystenyl SPamCys cysteine hexadecanoate thioester cysteine palmitate thioester PSI-MOD Palmitoyl Palmitoylation MOD:00115 From DeltaMass: (name misspelled "S-palmityl Cystenyl" and formula incorrect, N and O reversed) Formula: C19H35O1N2S1 Monoisotopic Mass Change: 341.239 Average Mass Change: 341.556 S-palmitoyl-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine. DeltaMass:303 PubMed:1872406 PubMed:3166978 PubMed:8180229 PubMed:8824274 RESID:AA0106 Unimod:47#C (2R)-2-amino-3-(hexadecanoylsulfanyl)propanoic acid 2-amino-3-(hexadecanoylthio)propanoic acid ACT_SITE S-palmitoyl cysteine intermediate LIPID S-palmitoyl cysteine S-hexadecanoylated L-cysteine S-palmitoyl-L-cysteine S-palmitoylated L-cysteine S-palmityl Cystenyl SPamCys cysteine hexadecanoate thioester cysteine palmitate thioester Palmitoyl Palmitoylation A protein modification that effectively converts an L-cysteine residue to S-diacylglycerol-L-cysteine. C natural PTM-0274 (2R)-2-amino-3-[(2S)-2-((9Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid 2-amino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid LIPID S-diacylglycerol cysteine S-(1-2'-oleoyl-3'-palmitoyl-glycerol)cysteine S-(2',3'-diacylglycerol)-L-cysteine S-diacylglycerol-L-cysteine SAcyl2GlyceroCys PSI-MOD Diacylglycerol diacylglycerol MOD:00116 Incidental to RESID:AA0060. S-diacylglycerol-L-cysteine A protein modification that effectively converts an L-cysteine residue to S-diacylglycerol-L-cysteine. PubMed:10896212 PubMed:4575979 PubMed:9056182 RESID:AA0107 Unimod:377#C (2R)-2-amino-3-[(2S)-2-((9Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]sulfanylpropanoic acid 2-amino-3-[(S)-2-((Z)-9-octadecenoyloxy)-3-(hexadecanoyloxy)propyl]thiopropanoic acid LIPID S-diacylglycerol cysteine S-(1-2'-oleoyl-3'-palmitoyl-glycerol)cysteine S-(2',3'-diacylglycerol)-L-cysteine S-diacylglycerol-L-cysteine SAcyl2GlyceroCys Diacylglycerol diacylglycerol A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia. -17.03 C 0 H -3 N -1 O 0 S 0 -17.026548 C 8 H 10 N 2 O 3 S 1 214.24 214.04121 C, Q natural PTM-0156 (2S)-2-amino-5-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-oxopentanoic acid (S,R)-2-amino-4-[S-(2-amino-2-carboxyethyl)thiocarboxy]butanoic acid 2-amino-5-(2-amino-2-carboxyethyl)thio-5-oxopentanoic acid CROSSLNK Isoglutamyl cysteine thioester (Cys-Gln) S-(L-isoglutamyl)-L-cysteine S-gamma-glutamyl (crosslinked to cysteine) XLNK-SCys-5Glu(Gln) gamma-(S-cysteinyl)glutamic acid PSI-MOD MOD:00117 Cross-link 2; DeltaMass calculates the mass difference from glutamic acid rather than glutamine. S-(L-isoglutamyl)-L-cysteine A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia. ChEBI:22021 DeltaMass:0 PubMed:6838833 RESID:AA0108 (2S)-2-amino-5-[(2R)-2-amino-2-carboxyethyl]sulfanyl-5-oxopentanoic acid (S,R)-2-amino-4-[S-(2-amino-2-carboxyethyl)thiocarboxy]butanoic acid 2-amino-5-(2-amino-2-carboxyethyl)thio-5-oxopentanoic acid CROSSLNK Isoglutamyl cysteine thioester (Cys-Gln) S-(L-isoglutamyl)-L-cysteine S-gamma-glutamyl (crosslinked to cysteine) XLNK-SCys-5Glu(Gln) gamma-(S-cysteinyl)glutamic acid A protein modification that effectively cross-links an L-cysteine residue and an L-histidine residue by a thioether bond to form 2'-(S-L-cysteinyl)-L-histidine. -2.02 C 0 H -2 N 0 O 0 S 0 -2.01565 C 9 H 10 N 4 O 2 S 1 238.26 238.05244 C, H natural PTM-0005 (2R)-2-amino-3-[(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)sulfanyl]propanoic acid (2S)-2-amino-3-[2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-1H-imidazol-4-yl]propanoic acid 2'-(L-cystein-S-yl)-L-histidine CROSSLNK 2'-(S-cysteinyl)-histidine (Cys-His) S-(2'-histidyl)cysteine S-(2-histidyl)- (crosslinked to cysteine) XLNK-SCys-2'His PSI-MOD MOD:00118 Cross-link 2. 2'-(S-L-cysteinyl)-L-histidine A protein modification that effectively cross-links an L-cysteine residue and an L-histidine residue by a thioether bond to form 2'-(S-L-cysteinyl)-L-histidine. DeltaMass:0 PubMed:6210696 RESID:AA0109 (2R)-2-amino-3-[(4-[(2S)-2-amino-2-carboxyethyl]-1H-imidazol-2-yl)sulfanyl]propanoic acid (2S)-2-amino-3-[2-([(2R)-2-amino-2-carboxyethyl]sulfanyl)-1H-imidazol-4-yl]propanoic acid 2'-(L-cystein-S-yl)-L-histidine CROSSLNK 2'-(S-cysteinyl)-histidine (Cys-His) S-(2'-histidyl)cysteine S-(2-histidyl)- (crosslinked to cysteine) XLNK-SCys-2'His A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine. -18.02 C 0 H -2 N 0 O -1 S 0 -18.010565 C 6 H 8 N 2 O 2 S 1 172.2 172.03065 C, S artifact (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) (R)-S-(2-amino-2-carboxyethyl)-L-cysteine (R,R)-2,6-diamino-4-thiaheptanedioic acid (R,R)-3,3'-thiobis-(2-aminopropanoic acid) (R,R)-bis(2-amino-2-carboxyethyl)sulfide 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid 3,3'-thiobis-L-alanine L-lanthionine XLNK-SCys-(L)3Dha PSI-MOD MOD:00119 Cross-link 2. The natural occurrence of this modification is rare. For the more common modification see MOD:00120 meso-lanthionine [JSG]. L-lanthionine (Cys-Ser) A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine. ChEBI:21347 DeltaMass:7 RESID:AA0110#CSX (2R,2'R)-3,3'-sulfanediylbis(2-aminopropanoic acid) (R)-S-(2-amino-2-carboxyethyl)-L-cysteine (R,R)-2,6-diamino-4-thiaheptanedioic acid (R,R)-3,3'-thiobis-(2-aminopropanoic acid) (R,R)-bis(2-amino-2-carboxyethyl)sulfide 2-amino-3-(2-amino-2-carboxyethyl)sulfanylpropanoic acid 3,3'-thiobis-L-alanine L-lanthionine XLNK-SCys-(L)3Dha A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form meso-lanthionine. -18.02 C 0 H -2 N 0 O -1 S 0 -18.010565 C 6 H 8 N 2 O 2 S 1 172.2 172.03065 C, S natural PTM-0164 (2R,2'S)-3,3'-sulfanediylbis(2-aminopropanoic acid) (2R,2'S)-3,3'-thiobis-(2-aminopropanoic acid) (2R,6S)-2,6-diamino-4-thiaheptanedioic acid (2R,6S)-meso-lanthionine (2S)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]sulfanyl]propanoic acid (R)-S-(2-amino-2-carboxyethyl)-D-cysteine (R,S)-bis(2-amino-2-carboxyethyl)sulfide 3,3'-thiobis-meso-alanine CROSSLNK Lanthionine (Cys-Ser) CROSSLNK Lanthionine (Ser-Cys) XLNK-SCys-(D)3Dha cysteine-3-D-alanine thioether meso-lanthionine PSI-MOD (2S,6R)-meso-lanthionine MOD:00120 Cross-link 2. meso-lanthionine A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form meso-lanthionine. PubMed:15023056 PubMed:3769923 RESID:AA0111 (2R,2'S)-3,3'-sulfanediylbis(2-aminopropanoic acid) (2R,2'S)-3,3'-thiobis-(2-aminopropanoic acid) (2R,6S)-2,6-diamino-4-thiaheptanedioic acid (2R,6S)-meso-lanthionine (2S)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]sulfanyl]propanoic acid (R)-S-(2-amino-2-carboxyethyl)-D-cysteine (R,S)-bis(2-amino-2-carboxyethyl)sulfide 3,3'-thiobis-meso-alanine CROSSLNK Lanthionine (Cys-Ser) CROSSLNK Lanthionine (Ser-Cys) XLNK-SCys-(D)3Dha cysteine-3-D-alanine thioether meso-lanthionine (2S,6R)-meso-lanthionine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine. -18.02 C 0 H -2 N 0 O -1 S 0 -18.010565 C 7 H 10 N 2 O 2 S 1 186.23 186.0463 C, T natural PTM-0067 (2S,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid (2S,3S,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid (2S,3S,2'R)-3-methyllanthionine (2S,3S,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid (2S,3S,6R)-3-methyllanthionine (2S-[2R*,3R*(S*)])-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid 3-methyl-D,L-lanthionine CROSSLNK Beta-methyllanthionine (Cys-Thr) CROSSLNK Beta-methyllanthionine (Thr-Cys) XLNK-SCys-3Dhb cysteine-3-D-butyrine thioether PSI-MOD MOD:00121 Cross-link 2. (2S,3S,2'R)-3-methyllanthionine A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine. PubMed:3769923 RESID:AA0112 (2S,3S)-2-amino-3-([(2R)-2-amino-2-carboxyethyl]sulfanyl)butanoic acid (2S,3S,2'R)-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid (2S,3S,2'R)-3-methyllanthionine (2S,3S,6R)-2,6-diamino-3-methyl-4-thiaheptanedioic acid (2S,3S,6R)-3-methyllanthionine (2S-[2R*,3R*(S*)])-2-amino-3-[(2-amino-2-carboxyethyl)thio]butanoic acid 3-methyl-D,L-lanthionine CROSSLNK Beta-methyllanthionine (Cys-Thr) CROSSLNK Beta-methyllanthionine (Thr-Cys) XLNK-SCys-3Dhb cysteine-3-D-butyrine thioether A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-tyrosine. -2.02 C 0 H -2 N 0 O 0 S 0 -2.01565 C 12 H 12 N 2 O 3 S 1 264.3 264.05685 C, Y natural PTM-0019 (2S)-2-amino-3-(3-[(2R)2-amino-2-carboxyethylsulfanyl]-4-hydroxyphenyl)propanoic acid 2-amino-3-[3-(2-amino-2-carboxyethylthio)-4-hydroxyphenyl]propanoic acid 3'-(L-cystein-S-yl)-L-tyrosine 3'-(cystein-S-yl)tyrosine CROSSLNK 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) CROSSLNK 3'-(S-cysteinyl)-tyrosine (Tyr-Cys) S-(3-Tyr) (Crosslinked to Cysteine) S-(tyros-3'-yl)cysteine XLNK-SCys-3'Tyr PSI-MOD MOD:00122 Cross-link 2. 3'-(S-L-cysteinyl)-L-tyrosine A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-tyrosine. DeltaMass:0 PubMed:15917234 PubMed:2002850 RESID:AA0113 (2S)-2-amino-3-(3-[(2R)2-amino-2-carboxyethylsulfanyl]-4-hydroxyphenyl)propanoic acid 2-amino-3-[3-(2-amino-2-carboxyethylthio)-4-hydroxyphenyl]propanoic acid 3'-(L-cystein-S-yl)-L-tyrosine 3'-(cystein-S-yl)tyrosine CROSSLNK 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) CROSSLNK 3'-(S-cysteinyl)-tyrosine (Tyr-Cys) S-(3-Tyr) (Crosslinked to Cysteine) S-(tyros-3'-yl)cysteine XLNK-SCys-3'Tyr A protein modification that effectively converts an L-lysine residue to N6-carboxy-L-lysine. 44.01 C 1 H 0 N 0 O 2 43.98983 C 7 H 12 N 2 O 3 172.18 172.0848 K natural PTM-0191 Unimod:299 (2S)-2-amino-6-(carboxyamino)hexanoic acid 2-amino-6-carbamic hexanoic acid MOD_RES N6-carboxylysine N6-carboxy-L-lysine N6-carboxylysine N6CbxLys lysine NZ-carboxylic acid PSI-MOD Carboxy Carboxylation N6-carbamyllysine MOD:00123 N6-carboxy-L-lysine A protein modification that effectively converts an L-lysine residue to N6-carboxy-L-lysine. PubMed:11369851 PubMed:4436319 PubMed:637859 PubMed:7754395 RESID:AA0114 Unimod:299#K (2S)-2-amino-6-(carboxyamino)hexanoic acid 2-amino-6-carbamic hexanoic acid MOD_RES N6-carboxylysine N6-carboxy-L-lysine N6-carboxylysine N6CbxLys lysine NZ-carboxylic acid Carboxy Carboxylation N6-carbamyllysine A protein modification that effectively converts an L-lysine residue to N6-1-carboxyethyl-L-lysine. 72.06 C 3 H 4 N 0 O 2 72.021126 C 9 H 16 N 2 O 3 200.24 200.11609 K natural PTM-0189 Unimod:378 (2S)-2-amino-6-([(1S)-1-carboxyethyl]amino)hexanoic acid MOD_RES N6-1-carboxyethyl lysine N6-(1-carboxyethyl)-L-lysine N6-(1-carboxyethyl)lysine N6CbzEtLys NZ-(1-carboxyethyl)lysine PSI-MOD Carboxyethyl carboxyethyl MOD:00124 N6-1-carboxyethyl-L-lysine A protein modification that effectively converts an L-lysine residue to N6-1-carboxyethyl-L-lysine. PubMed:3123486 PubMed:8253186 PubMed:8421682 RESID:AA0115 Unimod:378#K (2S)-2-amino-6-([(1S)-1-carboxyethyl]amino)hexanoic acid MOD_RES N6-1-carboxyethyl lysine N6-(1-carboxyethyl)-L-lysine N6-(1-carboxyethyl)lysine N6CbzEtLys NZ-(1-carboxyethyl)lysine Carboxyethyl carboxyethyl A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. 87.12 C 4 H 9 N 1 O 1 87.06841 C 10 H 21 N 3 O 2 215.3 215.16338 K natural PTM-0150 Unimod:379 (2S)-2-amino-6-([(2R)-4-amino-2-hydroxybutyl]amino)hexanoic acid (2S,9R)-2,11-diazanyl-9-hydroxy-7-azaundecanoic acid (2S,9R)-hypusine 2-azanyl-6-[(4-azanyl-2-hydroxybutyl)azanyl]hexanoic acid Hypu L-hypusine MOD_RES Hypusine N-(4-NH2-2-OH-butyl)- (of Lysine) N6-(4-amino-2-hydroxybutyl)-L-lysine PSI-MOD Hypusine hypusine MOD:00125 This modification occurs uniquely in translation initiation factor eIF-5A [JSG]. hypusine A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. DeltaMass:0 PubMed:6806267 PubMed:8108861 RESID:AA0116 Unimod:379#K (2S)-2-amino-6-([(2R)-4-amino-2-hydroxybutyl]amino)hexanoic acid (2S,9R)-2,11-diazanyl-9-hydroxy-7-azaundecanoic acid (2S,9R)-hypusine 2-azanyl-6-[(4-azanyl-2-hydroxybutyl)azanyl]hexanoic acid Hypu L-hypusine MOD_RES Hypusine N-(4-NH2-2-OH-butyl)- (of Lysine) N6-(4-amino-2-hydroxybutyl)-L-lysine Hypusine hypusine A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine. 226.29 C 10 H 14 N 2 O 2 S 1 226.0776 C 16 H 26 N 4 O 3 S 1 354.47 354.17258 K natural PTM-0382 Unimod:3 (2S)-2-amino-6-(5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoylamino)hexanoic acid (3aS-(3aalpha,4beta,6aalpha))-N6-(5-(hexahydro-2-oxo-1H-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)-L-lysine MOD_RES N6-biotinyllysine N6-[5-((3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-L-lysine N6-biotinyl-L-lysine N6-biotinyllysine N6BtnLys biocytin