{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "# ISA Create Mode example"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Abstract:\n",
    "    \n",
    "In this notebook, we'll show how to generate an ISA-Tab and an ISA JSON representation of a metabolomics study.\n",
    "The study uses GC-MS and 13C NMR on 3 distinct sample types (liver, blood and heart) collected from study subjects assigned to 3 distinct study arms.\n",
    "\n",
    "GC-MS acquisition were carried out in duplicate, extracts were derivatized using BSA and acquired on an Agilent QTOF in both positive and negative modes.\n",
    "13C NMR free induction decays were acquired on a Bruker Avance, using CPMG and PSEQ pulse sequences in duplicates.\n",
    "\n"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### 1. Loading ISA-API model and relevant library"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "# If executing the notebooks on `Google Colab`,uncomment the following command \n",
    "# and run it to install the required python libraries. Also, make the test datasets available.\n",
    "\n",
    "# !pip install -r requirements.txt"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "from isatools import isatab\n",
    "from isatools.isajson import ISAJSONEncoder\n",
    "from collections import OrderedDict\n",
    "from isatools.model import (\n",
    "    Investigation,\n",
    "    OntologyAnnotation,\n",
    "    FactorValue,\n",
    "    Characteristic\n",
    ")\n",
    "from isatools.create.model import (\n",
    "    Treatment,\n",
    "    NonTreatment,\n",
    "    StudyCell,\n",
    "    StudyArm,\n",
    "    ProductNode,\n",
    "    SampleAndAssayPlan,\n",
    "    StudyDesign,\n",
    "    QualityControl\n",
    ")\n",
    "from isatools.create.constants import (\n",
    "    BASE_FACTORS,\n",
    "    SCREEN,\n",
    "    RUN_IN,\n",
    "    WASHOUT,\n",
    "    FOLLOW_UP,\n",
    "    SAMPLE,\n",
    "    EXTRACT,\n",
    "    LABELED_EXTRACT,\n",
    "    DATA_FILE\n",
    ")\n",
    "from isatools.isatab import dump_tables_to_dataframes as dumpdf\n",
    "import os\n",
    "import json"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### 2. Setting variables:"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [],
   "source": [
    "NAME = 'name'\n",
    "FACTORS_0_VALUE = OntologyAnnotation(term='nitroglycerin')\n",
    "FACTORS_0_VALUE_ALT = OntologyAnnotation(term='alcohol')\n",
    "FACTORS_0_VALUE_THIRD = OntologyAnnotation(term='water')\n",
    "\n",
    "FACTORS_1_VALUE = 5\n",
    "FACTORS_1_UNIT = OntologyAnnotation(term='kg/m^3')\n",
    "\n",
    "FACTORS_2_VALUE = 100.0\n",
    "FACTORS_2_VALUE_ALT = 50.0\n",
    "FACTORS_2_UNIT = OntologyAnnotation(term='s')\n",
    "\n",
    "TEST_EPOCH_0_NAME = 'test epoch 0'\n",
    "TEST_EPOCH_1_NAME = 'test epoch 1'\n",
    "TEST_EPOCH_2_NAME = 'test epoch 2'\n",
    "\n",
    "TEST_STUDY_ARM_NAME_00 = 'test arm'\n",
    "TEST_STUDY_ARM_NAME_01 = 'another arm'\n",
    "TEST_STUDY_ARM_NAME_02 = 'yet another arm'\n",
    "\n",
    "TEST_STUDY_DESIGN_NAME = 'test study design'\n",
    "\n",
    "TEST_EPOCH_0_RANK = 0\n",
    "\n",
    "SCREEN_DURATION_VALUE = 100\n",
    "FOLLOW_UP_DURATION_VALUE = 5*366\n",
    "WASHOUT_DURATION_VALUE = 30\n",
    "DURATION_UNIT = OntologyAnnotation(term='day')"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### 3. Declaration of ISA Sample / Biomaterial templates for liver, blood and heart"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [],
   "source": [
    "sample_list = [\n",
    "        {\n",
    "            'node_type': SAMPLE,\n",
    "            'characteristics_category': OntologyAnnotation(term='organism part'),\n",
    "            'characteristics_value': OntologyAnnotation(term='liver'),\n",
    "            'size': 1,\n",
    "            'technical_replicates': None,\n",
    "            'is_input_to_next_protocols': True\n",
    "        },\n",
    "        {\n",
    "            'node_type': SAMPLE,\n",
    "            'characteristics_category': OntologyAnnotation(term='organism part'),\n",
    "            'characteristics_value': OntologyAnnotation(term='blood'),\n",
    "            'size': 1,\n",
    "            'technical_replicates': None,\n",
    "            'is_input_to_next_protocols': True\n",
    "        },\n",
    "        {\n",
    "            'node_type': SAMPLE,\n",
    "            'characteristics_category': OntologyAnnotation(term='organism part'),\n",
    "            'characteristics_value': OntologyAnnotation(term='heart'),\n",
    "            'size': 1,\n",
    "            'technical_replicates': None,\n",
    "            'is_input_to_next_protocols': True\n",
    "        }\n",
    "]"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### 4. Declaration of ISA Assay templates as Python `OrderedDict`"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [],
   "source": [
    "# A Mass Spectrometry based metabolite profiling assay\n",
    "\n",
    "ms_assay_dict = OrderedDict([\n",
    "    ('measurement_type', OntologyAnnotation(term='metabolite profiling')),\n",
    "    ('technology_type', OntologyAnnotation(term='mass spectrometry')),\n",
    "    ('extraction', {}),\n",
    "    ('extract', [\n",
    "        {\n",
    "            'node_type': EXTRACT,\n",
    "            'characteristics_category': OntologyAnnotation(term='extract type'),\n",
    "            'characteristics_value': OntologyAnnotation(term='polar fraction'),\n",
    "            'size': 1,\n",
    "            'is_input_to_next_protocols': True\n",
    "        },\n",
    "        {\n",
    "            'node_type': EXTRACT,\n",
    "            'characteristics_category': OntologyAnnotation(term='extract type'),\n",
    "            'characteristics_value': OntologyAnnotation(term='lipids'),\n",
    "            'size': 1,\n",
    "            'is_input_to_next_protocols': True\n",
    "        }\n",
    "    ]),\n",
    "    ('derivatization', {\n",
    "        '#replicates': 1,\n",
    "        OntologyAnnotation(term='derivatization'): ['sylalation'],\n",
    "        OntologyAnnotation(term='derivatization'): ['bis(trimethylsilyl)acetamide'],\n",
    "    }),\n",
    "    ('labeled extract', [\n",
    "        {\n",
    "            'node_type': LABELED_EXTRACT,\n",
    "            'characteristics_category': OntologyAnnotation(term='labeled extract type'),\n",
    "            'characteristics_value': '',\n",
    "            'size': 1,\n",
    "            'is_input_to_next_protocols': True\n",
    "        }\n",
    "    ]),\n",
    "    ('mass spectrometry', {\n",
    "        '#replicates': 2,\n",
    "        OntologyAnnotation(term='instrument'): ['Agilent QTOF'],\n",
    "        OntologyAnnotation(term='injection_mode'): ['GC'],\n",
    "        OntologyAnnotation(term='acquisition_mode'): ['positive mode','negative mode']\n",
    "    }),\n",
    "    ('raw spectral data file', [\n",
    "        {\n",
    "            'node_type': DATA_FILE,\n",
    "            'size': 1,\n",
    "            'is_input_to_next_protocols': False\n",
    "        }\n",
    "    ])\n",
    "])\n",
    "\n",
    "\n",
    "# A high-throughput phenotyping imaging based phenotyping assay\n",
    "\n",
    "phti_assay_dict = OrderedDict([\n",
    "    ('measurement_type', OntologyAnnotation(term='phenotyping')),\n",
    "    ('technology_type', OntologyAnnotation(term='high-throughput imaging')),\n",
    "            ('extraction', {}),\n",
    "            ('extract', [\n",
    "                {\n",
    "                    'node_type': EXTRACT,\n",
    "                    'characteristics_category': OntologyAnnotation(term='extract type'),\n",
    "                    'characteristics_value': OntologyAnnotation(term='supernatant'),\n",
    "                    'size': 1,\n",
    "                    'technical_replicates': None,\n",
    "                    'is_input_to_next_protocols': True\n",
    "                },\n",
    "                {\n",
    "                    'node_type': EXTRACT,\n",
    "                    'characteristics_category': OntologyAnnotation(term='extract type'),\n",
    "                    'characteristics_value': OntologyAnnotation(term='pellet'),\n",
    "                    'size': 1,\n",
    "                    'technical_replicates': None,\n",
    "                    'is_input_to_next_protocols': True\n",
    "                }\n",
    "            ]),\n",
    "            ('phenotyping by high throughput imaging', {\n",
    "                'OntologyAnnotation(term=instrument)': ['lemnatech gigant'],\n",
    "                'OntologyAnnotation(term=acquisition_mode)': ['UV light','near-IR light','far-IR light','visible light'],\n",
    "                'OntologyAnnotation(term=camera position)': ['top','120 degree','240 degree','360 degree'],\n",
    "                'OntologyAnnotation(term=imaging daily schedule)': ['06.00','19.00']\n",
    "            }),\n",
    "            ('raw_spectral_data_file', [\n",
    "                {\n",
    "                    'node_type': DATA_FILE,\n",
    "                    'size': 1,\n",
    "                    'technical_replicates': 2,\n",
    "                    'is_input_to_next_protocols': False\n",
    "                }\n",
    "            ])\n",
    "        ])\n",
    "\n",
    "# A liquid chromatography diode-array based metabolite profiling assay\n",
    "\n",
    "lcdad_assay_dict = OrderedDict([\n",
    "    ('measurement_type', OntologyAnnotation(term='metabolite identification')),\n",
    "    ('technology_type', OntologyAnnotation(term='liquid chromatography diode-array detector')),\n",
    "            ('extraction', {}),\n",
    "            ('extract', [\n",
    "                {\n",
    "                    'node_type': EXTRACT,\n",
    "                    'characteristics_category': OntologyAnnotation(term='extract type'),\n",
    "                    'characteristics_value': OntologyAnnotation(term='supernatant'),\n",
    "                    'size': 1,\n",
    "                    'technical_replicates': None,\n",
    "                    'is_input_to_next_protocols': True\n",
    "                },\n",
    "                {\n",
    "                    'node_type': EXTRACT,\n",
    "                    'characteristics_category': OntologyAnnotation(term='extract type'),\n",
    "                    'characteristics_value': OntologyAnnotation(term='pellet'),\n",
    "                    'size': 1,\n",
    "                    'technical_replicates': None,\n",
    "                    'is_input_to_next_protocols': True\n",
    "                }\n",
    "            ]),\n",
    "            ('lcdad_spectroscopy', {\n",
    "                'OntologyAnnotation(term=instrument)': ['Shimadzu DAD 400'],\n",
    "            }),\n",
    "            ('raw_spectral_data_file', [\n",
    "                {\n",
    "                    'node_type': DATA_FILE,\n",
    "                    'size': 1,\n",
    "                    'technical_replicates': 2,\n",
    "                    'is_input_to_next_protocols': False\n",
    "                }\n",
    "            ])\n",
    "        ])\n",
    "\n",
    "\n",
    "# A NMR spectroscopy based metabolite profiling assay:\n",
    "nmr_assay_dict = OrderedDict([\n",
    "    ('measurement_type', OntologyAnnotation(term='metabolite profiling')),\n",
    "    ('technology_type', OntologyAnnotation(term='nmr spectroscopy')),\n",
    "            ('extraction', {}),\n",
    "            ('extract', [\n",
    "                {\n",
    "                    'node_type': EXTRACT,\n",
    "                    'characteristics_category':  OntologyAnnotation(term='extract type'),\n",
    "                    'characteristics_value': OntologyAnnotation(term='supernatant'),\n",
    "                    'size': 1,\n",
    "                    'technical_replicates': None,\n",
    "                    'is_input_to_next_protocols': True\n",
    "                },\n",
    "                {\n",
    "                    'node_type': EXTRACT,\n",
    "                    'characteristics_category':  OntologyAnnotation(term='extract type'),\n",
    "                    'characteristics_value': OntologyAnnotation(term='pellet'),\n",
    "                    'size': 1,\n",
    "                    'technical_replicates': None,\n",
    "                    'is_input_to_next_protocols': True\n",
    "                }\n",
    "            ]),\n",
    "            ('nmr spectroscopy', {\n",
    "                OntologyAnnotation(term='instrument'): [OntologyAnnotation(term='Bruker AvanceII 1 GHz')],\n",
    "                OntologyAnnotation(term='acquisition_mode'): [OntologyAnnotation(term='1D 13C NMR')],\n",
    "                OntologyAnnotation(term='pulse_sequence'): [OntologyAnnotation(term='CPMG')]\n",
    "            }),\n",
    "            ('raw_spectral_data_file', [\n",
    "                {\n",
    "                    'node_type': DATA_FILE,\n",
    "                    'size': 1,\n",
    "                    'technical_replicates': 1,\n",
    "                    'is_input_to_next_protocols': False\n",
    "                }\n",
    "            ])\n",
    "    ])"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### 5. Declaring Study Design key elements in terms of Treatments and Non-Treatment elements, Study Cell & Arms"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [],
   "source": [
    "first_treatment = Treatment(factor_values=(\n",
    "    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE),\n",
    "    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),\n",
    "    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE, unit=FACTORS_2_UNIT)\n",
    "))\n",
    "second_treatment = Treatment(factor_values=(\n",
    "    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE_ALT),\n",
    "    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),\n",
    "    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE, unit=FACTORS_2_UNIT)\n",
    "))\n",
    "third_treatment = Treatment(factor_values=(\n",
    "    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE_ALT),\n",
    "    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),\n",
    "    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE_ALT, unit=FACTORS_2_UNIT)\n",
    "))\n",
    "fourth_treatment = Treatment(factor_values=(\n",
    "    FactorValue(factor_name=BASE_FACTORS[0], value=FACTORS_0_VALUE_THIRD),\n",
    "    FactorValue(factor_name=BASE_FACTORS[1], value=FACTORS_1_VALUE, unit=FACTORS_1_UNIT),\n",
    "    FactorValue(factor_name=BASE_FACTORS[2], value=FACTORS_2_VALUE, unit=FACTORS_2_UNIT)\n",
    "))\n",
    "screen = NonTreatment(element_type=SCREEN, duration_value=SCREEN_DURATION_VALUE, duration_unit=DURATION_UNIT)\n",
    "run_in = NonTreatment(element_type=RUN_IN, duration_value=WASHOUT_DURATION_VALUE, duration_unit=DURATION_UNIT)\n",
    "washout = NonTreatment(element_type=WASHOUT, duration_value=WASHOUT_DURATION_VALUE, duration_unit=DURATION_UNIT)\n",
    "follow_up = NonTreatment(element_type=FOLLOW_UP, duration_value=FOLLOW_UP_DURATION_VALUE, duration_unit=DURATION_UNIT)\n",
    "potential_concomitant_washout = NonTreatment(element_type=WASHOUT, duration_value=FACTORS_2_VALUE,\n",
    "                                                          duration_unit=FACTORS_2_UNIT)\n",
    "cell_screen = StudyCell(SCREEN, elements=(screen,))\n",
    "cell_run_in = StudyCell(RUN_IN, elements=(run_in,))\n",
    "cell_other_run_in = StudyCell('OTHER RUN-IN', elements=(run_in,))\n",
    "cell_screen_and_run_in = StudyCell('SCREEN AND RUN-IN', elements=[screen, run_in])\n",
    "cell_concomitant_treatments = StudyCell('CONCOMITANT TREATMENTS',\n",
    "                                                     elements=([{second_treatment, fourth_treatment}]))\n",
    "cell_washout_00 = StudyCell(WASHOUT, elements=(washout,))\n",
    "cell_washout_01 = StudyCell('ANOTHER WASHOUT', elements=(washout,))\n",
    "cell_single_treatment_00 = StudyCell('SINGLE TREATMENT FIRST', elements=[first_treatment])\n",
    "cell_single_treatment_01 = StudyCell('SINGLE TREATMENT SECOND', elements=[second_treatment])\n",
    "cell_single_treatment_02 = StudyCell('SINGLE TREATMENT THIRD', elements=[third_treatment])\n",
    "cell_multi_elements = StudyCell('MULTI ELEMENTS',\n",
    "                                             elements=[{first_treatment, second_treatment,\n",
    "                                                        fourth_treatment}, washout, second_treatment])\n",
    "cell_multi_elements_padded = StudyCell('MULTI ELEMENTS PADDED',\n",
    "                                                    elements=[first_treatment, washout, {\n",
    "                                                        second_treatment,\n",
    "                                                        fourth_treatment\n",
    "                                                    }, washout, third_treatment, washout])\n",
    "cell_follow_up = StudyCell(FOLLOW_UP, elements=(follow_up,))\n",
    "cell_follow_up_01 = StudyCell('ANOTHER FOLLOW_UP', elements=(follow_up,))\n",
    "qc = QualityControl()\n",
    "\n",
    "ms_sample_assay_plan = SampleAndAssayPlan.from_sample_and_assay_plan_dict(\"ms_sap\", sample_list, ms_assay_dict)\n",
    "nmr_sample_assay_plan = SampleAndAssayPlan.from_sample_and_assay_plan_dict(\"nmr_sap\", sample_list, nmr_assay_dict)\n",
    "\n",
    "first_arm = StudyArm(name=TEST_STUDY_ARM_NAME_00, group_size=3, arm_map=OrderedDict([\n",
    "    (cell_screen, None), (cell_run_in, None),\n",
    "    (cell_single_treatment_00, ms_sample_assay_plan),\n",
    "    (cell_follow_up, ms_sample_assay_plan)\n",
    "]))\n",
    "second_arm = StudyArm(name=TEST_STUDY_ARM_NAME_01, group_size=5, arm_map=OrderedDict([\n",
    "    (cell_screen, None), (cell_run_in, None),\n",
    "    (cell_multi_elements, ms_sample_assay_plan),\n",
    "    (cell_follow_up, ms_sample_assay_plan)\n",
    "]))\n",
    "third_arm = StudyArm(name=TEST_STUDY_ARM_NAME_02, group_size=3, arm_map=OrderedDict([\n",
    "    (cell_screen, None), (cell_run_in, None),\n",
    "    (cell_multi_elements_padded, ms_sample_assay_plan),\n",
    "    (cell_follow_up, ms_sample_assay_plan)\n",
    "]))\n",
    "third_arm_no_run_in = StudyArm(name=TEST_STUDY_ARM_NAME_02, group_size=3, arm_map=OrderedDict([\n",
    "    (cell_screen, None),\n",
    "    (cell_multi_elements_padded, ms_sample_assay_plan),\n",
    "    (cell_follow_up, ms_sample_assay_plan)\n",
    "]))\n",
    "arm_same_name_as_third = StudyArm(name=TEST_STUDY_ARM_NAME_02, group_size=5, arm_map=OrderedDict([\n",
    "    (cell_screen, None), (cell_run_in, None),\n",
    "    (cell_single_treatment_01, ms_sample_assay_plan),\n",
    "    (cell_follow_up, ms_sample_assay_plan)\n",
    "]))\n",
    "        # Sample QC (for mass spectroscopy and other)\n",
    "pre_run_sample_type = ProductNode(\n",
    "    id_='pre/00', node_type=SAMPLE, name='water', size=2, characteristics=(\n",
    "        Characteristic(category='dilution', value=10, unit='mg/L'),\n",
    "    )\n",
    ")\n",
    "post_run_sample_type = ProductNode(\n",
    "    id_='post/00', node_type=SAMPLE, name='ethanol', size=2, characteristics=(\n",
    "        Characteristic(category='dilution', value=1000, unit='mg/L'),\n",
    "        Characteristic(category='dilution', value=100, unit='mg/L'),\n",
    "        Characteristic(category='dilution', value=10, unit='mg/L'),\n",
    "        Characteristic(category='dilution', value=1, unit='mg/L'),\n",
    "        Characteristic(category='dilution', value=0.1, unit='mg/L')\n",
    "    ))\n",
    "dummy_sample_type = ProductNode(id_='dummy/01', node_type=SAMPLE, name='dummy')\n",
    "more_dummy_sample_type = ProductNode(id_='dummy/02', node_type=SAMPLE, name='more dummy')\n",
    "interspersed_sample_types = [(dummy_sample_type, 20)]\n",
    "qc = QualityControl(\n",
    "    interspersed_sample_type=interspersed_sample_types,\n",
    "    pre_run_sample_type=pre_run_sample_type,\n",
    "    post_run_sample_type=post_run_sample_type\n",
    ")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [],
   "source": [
    "single_arm = StudyArm(name=TEST_STUDY_ARM_NAME_00, group_size=10, arm_map=OrderedDict([\n",
    "    (cell_screen, ms_sample_assay_plan), (cell_run_in,ms_sample_assay_plan),\n",
    "    (cell_single_treatment_00, nmr_sample_assay_plan),\n",
    "    (cell_follow_up, nmr_sample_assay_plan)\n",
    "]))\n",
    "study_design = StudyDesign(study_arms=(single_arm,))\n"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### 6. Generated ISA Study from ISA Study Design Object"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {},
   "outputs": [],
   "source": [
    "study = study_design.generate_isa_study()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
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       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S1-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S1-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S2-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S2-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S3-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S3-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S4-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S4-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S5-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S5-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S6-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S6-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S7-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S7-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S8-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S8-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S9-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S9-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S10-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S10-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S11-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S11-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S12-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S12-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S13-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S13-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S14-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S14-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S15-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S15-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S16-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S16-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S17-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S17-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S17-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S17-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S17-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S17-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S18-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S18-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S18-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S18-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S18-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S18-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S19-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S19-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S19-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S19-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S19-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S19-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S20-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S20-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S20-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S20-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S20-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S20-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S21-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S21-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S21-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S21-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S21-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S21-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S22-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S22-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S22-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S22-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S22-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S22-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S23-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S23-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S23-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S23-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S23-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S23-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S24-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S24-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S24-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S24-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S24-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S24-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S25-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S25-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S25-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S25-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S25-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S25-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S26-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S26-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S26-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S26-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S26-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S26-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S27-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S27-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S27-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S27-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S27-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S27-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S28-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S28-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S28-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S28-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S28-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S28-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S29-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S29-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S29-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S29-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S29-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S29-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])], outputs=[isatools.model.Extract(name='AT0-S30-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S30-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S30-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S30-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S30-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S30-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S31-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S31-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S31-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S31-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S31-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S31-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S32-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S32-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S32-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S32-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S32-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S32-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S33-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S33-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S33-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S33-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S33-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S33-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S34-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S34-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S34-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S34-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S34-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S34-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S35-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S35-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S35-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S35-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S35-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S35-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S36-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S36-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S36-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S36-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S36-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S36-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S37-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S37-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S37-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S37-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S37-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S37-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S38-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S38-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S38-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S38-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S38-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S38-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S39-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S39-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S39-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S39-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S39-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S39-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S40-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S40-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S40-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S40-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S40-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S40-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S41-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S41-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S41-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S41-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S41-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S41-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S42-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S42-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S42-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S42-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S42-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S42-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S43-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S43-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S43-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S43-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S43-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S43-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S44-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S44-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S44-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S44-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S44-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S44-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S45-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S45-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S45-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S45-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S45-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S45-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S46-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S46-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S46-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S46-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S46-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S46-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S47-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S47-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S47-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S47-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S47-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S47-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S48-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S48-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S48-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S48-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S48-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S48-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S49-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S49-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S49-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S49-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S49-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S49-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S50-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S50-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S50-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S50-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S50-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S50-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S51-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S51-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S51-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S51-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S51-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S51-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S52-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S52-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S52-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S52-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S52-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S52-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S53-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S53-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S53-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S53-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S53-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S53-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S54-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S54-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S54-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S54-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S54-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S54-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S55-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S55-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S55-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S55-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S55-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S55-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S56-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S56-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S56-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S56-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S56-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S56-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S57-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S57-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S57-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S57-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S57-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S57-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S58-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S58-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S58-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S58-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S58-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S58-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S59-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S59-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S59-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S59-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S59-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S59-raw_spectral_data_file-R2-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S60-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S60-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---nmr-spectroscopy-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_001, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S60-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S60-raw_spectral_data_file-R1-', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---nmr-spectroscopy-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=nmr_spectroscopy_000_000, \n",
       "        name=assay0 - nmr spectroscopy, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - nmr spectroscopy\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='Bruker AvanceII 1 GHz', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='1D 13C NMR', term_source=None, term_accession='', comments=[]), unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='pulse_sequence', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='CPMG', term_source=None, term_accession='', comments=[]), unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S60-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='supernatant', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawDataFile(filename='AT0-S60-raw_spectral_data_file-R2-', generated_from=[], comments=[])])], other_material=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='pellet', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), 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isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R8', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R1', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R2', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R3', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R4', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R5', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R6', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R7', generated_from=[], comments=[]), isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R8', generated_from=[], comments=[])], samples=[], process_sequence=[isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S1-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S1-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S2-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S2-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S3-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S3-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S4-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S4-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S5-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S5-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S6-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S6-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S7-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S7-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S7-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S7-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S8-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S8-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S8-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S8-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S9-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S9-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S9-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S9-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S10-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S10-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S10-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S10-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S11-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S11-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S11-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S11-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S12-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S12-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S12-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S12-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S13-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S13-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S13-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S13-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S14-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S14-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S14-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S14-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S15-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S15-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S15-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S15-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S16-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S16-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S16-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S16-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S17-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S17-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S17-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S17-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S17-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S17-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S17-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S18-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S18-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S18-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S18-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S18-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S18-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S18-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S19-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S19-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S19-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S19-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S19-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S19-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S19-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S20-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S20-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S20-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S20-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S20-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S20-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S20-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S21-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S21-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S21-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S21-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S21-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S21-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S21-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S22-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S22-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S22-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S22-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S22-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S22-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S22-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S23-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S23-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S23-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S23-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S23-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S23-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S23-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S24-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S24-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S24-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S24-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S24-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S24-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S24-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S25-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S25-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S25-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S25-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S25-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S25-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S25-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S26-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S26-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S26-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S26-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S26-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S26-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S26-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S27-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S27-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S27-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S27-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S27-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S27-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S27-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S28-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S28-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S28-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S28-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S28-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S28-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S28-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S29-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S29-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S29-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S29-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S29-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S29-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S29-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S30-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S30-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S30-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S30-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S30-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S30-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S30-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S31-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S31-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S31-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S31-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S31-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S31-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S31-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S32-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S32-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S32-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S32-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S32-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S32-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S32-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S33-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S33-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S33-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S33-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S33-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S33-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S33-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S34-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S34-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S34-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S34-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S34-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S34-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S34-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S35-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S35-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S35-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S35-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S35-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S35-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S35-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S36-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S36-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S36-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S36-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S36-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S36-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S36-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S37-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S37-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S37-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S37-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S37-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S37-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S37-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S38-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S38-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S38-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S38-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S38-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S38-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S38-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S39-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S39-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S39-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S39-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S39-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S39-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S39-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S40-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S40-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S40-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S40-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S40-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S40-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S40-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S41-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S41-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S41-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S41-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S41-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S41-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S41-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S42-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S42-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S42-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S42-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S42-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S42-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S42-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S43-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S43-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S43-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S43-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S43-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S43-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S43-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S44-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S44-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S44-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S44-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S44-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S44-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S44-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S45-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S45-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S45-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S45-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S45-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S45-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S45-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S46-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S46-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S46-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S46-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S46-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S46-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S46-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S47-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S47-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S47-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S47-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S47-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S47-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S47-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S48-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S48-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S48-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S48-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S48-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S48-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S48-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S49-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S49-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S49-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S49-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S49-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S49-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S49-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S50-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S50-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S50-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S50-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S50-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S50-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S50-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S51-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S51-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S51-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S51-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S51-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S51-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S51-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S52-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S52-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S52-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S52-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S52-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S52-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S52-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S53-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S53-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S53-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S53-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S53-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S53-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S53-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S54-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S54-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S54-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S54-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S54-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S54-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S54-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S55-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S55-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S55-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S55-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S55-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S55-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S55-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S56-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S56-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S56-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S56-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S56-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S56-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S56-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S57-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S57-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S57-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S57-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S57-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S57-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S57-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S58-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S58-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S58-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S58-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S58-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S58-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S58-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S59-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S59-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S59-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S59-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S59-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S59-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S59-raw-spectral-data-file-R8', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---extraction-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=extraction_000, \n",
       "        name=assay0 - extraction, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - extraction\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], outputs=[isatools.model.Extract(name='AT0-S60-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S60-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---derivatization-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_000, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S60-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---mass-spectrometry-Acquisition-R1\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R1', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---mass-spectrometry-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R2', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---mass-spectrometry-Acquisition-R3\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R3', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---mass-spectrometry-Acquisition-R4\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_000, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R4', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---derivatization-Acquisition-R2\", executes_protocol=ProtocolNode(\n",
       "        id=derivatization_000_001, \n",
       "        name=assay0 - derivatization, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - derivatization\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='derivatization', term_source=None, term_accession='', comments=[]), comments=[]), value='bis(trimethylsilyl)acetamide', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.Extract(name='AT0-S60-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---mass-spectrometry-Acquisition-R5\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R5', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---mass-spectrometry-Acquisition-R6\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_001_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='negative mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R6', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---mass-spectrometry-Acquisition-R7\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R7', generated_from=[], comments=[])]), isatools.model.Process(id=\"\". name=\"AT0-S60-assay0---mass-spectrometry-Acquisition-R8\", executes_protocol=ProtocolNode(\n",
       "        id=mass_spectrometry_000_001, \n",
       "        name=assay0 - mass spectrometry, \n",
       "        protocol_type=OntologyAnnotation(\n",
       "    term=assay0 - mass spectrometry\n",
       "    term_source=\n",
       "    term_accession=\n",
       "    comments=0 Comment objects\n",
       "), \n",
       "        uri=, \n",
       "        description=, \n",
       "        version=, \n",
       "        parameter_values=[isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='instrument', term_source=None, term_accession='', comments=[]), comments=[]), value='Agilent QTOF', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='injection_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='GC', unit=None, comments=[]), isatools.model.ParameterValue(category=isatools.model.ProtocolParameter(parameter_name=isatools.model.OntologyAnnotation(term='acquisition_mode', term_source=None, term_accession='', comments=[]), comments=[]), value='positive mode', unit=None, comments=[])])\n",
       "        , date=\"None\", performer=\"Unknown\", inputs=[isatools.model.LabeledExtract(name='AT0-S60-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[])], outputs=[isatools.model.RawSpectralDataFile(filename='AT0-S60-raw-spectral-data-file-R8', generated_from=[], comments=[])])], other_material=[isatools.model.Extract(name='AT0-S1-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S1-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S1-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S1-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S2-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S2-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S2-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S2-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S3-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S3-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S3-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S3-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S4-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S4-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S4-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S4-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S5-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S5-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S5-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S5-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S6-Extract-R1', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='polar fraction', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S6-LE-R1', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S6-Extract-R2', type='Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='extract type', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='lipids', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], comments=[]), isatools.model.LabeledExtract(name='AT0-S6-LE-R2', type='Labeled Extract Name', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='labeled extract type', term_source=None, term_accession='', comments=[]), value='', unit=None, comments=[])], comments=[]), isatools.model.Extract(name='AT0-S7-Extract-R1', type='Extract Name', 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characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')]), isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')]), isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')]), isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')]), isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])], process_sequence=[isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_screen_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=0, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_run-in_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=1, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=30, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_SINGLE-TREATMENT-FIRST_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=2, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='AGENT', factor_type=isatools.model.OntologyAnnotation(term='perturbation agent', term_source=None, term_accession='', comments=[]), comments=[]), value=isatools.model.OntologyAnnotation(term='nitroglycerin', term_source=None, term_accession='', comments=[]), unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=100.0, unit=isatools.model.OntologyAnnotation(term='s', term_source=None, term_accession='', comments=[])), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='INTENSITY', factor_type=isatools.model.OntologyAnnotation(term='intensity', term_source=None, term_accession='', comments=[]), comments=[]), value=5, unit=isatools.model.OntologyAnnotation(term='kg/m^3', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='YES')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-blood-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='blood', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-liver-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='liver', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ02_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ02', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ09_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ09', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ03_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ03', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ04_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ04', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ07_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ07', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ08_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ08', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ10_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ10', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ01_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ01', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ06_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ06', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])]), isatools.model.Process(id=\"\". name=\"None\", executes_protocol=Protocol(\n",
       "    name=sample collection\n",
       "    protocol_type=sample_collection\n",
       "    uri=\n",
       "    version=\n",
       "    parameters=2 ProtocolParameter objects\n",
       "    components=0 OntologyAnnotation objects\n",
       "    comments=0 Comment objects\n",
       "), date=\"2021-12-03\", performer=\"Unknown\", inputs=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], outputs=[isatools.model.Sample(name='GRP1_SBJ05_follow-up_SMP-heart-1', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='organism part', term_source=None, term_accession='', comments=[]), value=isatools.model.OntologyAnnotation(term='heart', term_source=None, term_accession='', comments=[]), unit=None, comments=[])], factor_values=[isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='Sequence Order', factor_type=isatools.model.OntologyAnnotation(term='sequence order', term_source=None, term_accession='', comments=[]), comments=[]), value=3, unit=None), isatools.model.FactorValue(factor_name=isatools.model.StudyFactor(name='DURATION', factor_type=isatools.model.OntologyAnnotation(term='time', term_source=None, term_accession='', comments=[]), comments=[]), value=1830, unit=isatools.model.OntologyAnnotation(term='day', term_source=None, term_accession='', comments=[]))], derives_from=[isatools.model.Source(name='GRP1_SBJ05', characteristics=[isatools.model.Characteristic(category=isatools.model.OntologyAnnotation(term='Study Subject', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C41189', comments=[]), value=isatools.model.OntologyAnnotation(term='Human', term_source=isatools.model.OntologySource(name='NCIT', file='http://purl.obolibrary.org/obo/ncit/releases/2019-03-02/ncit.owl', version='19.02d', description='NCI Thesaurus OBO Edition', comments=[]), term_accession='http://purl.obolibrary.org/obo/NCIT_C14225', comments=[]), unit=None, comments=[])], comments=[])], comments=[isatools.model.Comment(name='study step with treatment', value='NO')])])], other_material=[], characteristic_categories=[], comments=[], units=[])"
      ]
     },
     "execution_count": 9,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "study"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {},
   "outputs": [],
   "source": [
    "treatment_assay = next(iter(study.assays))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "<networkx.classes.digraph.DiGraph at 0x12ffa49a0>"
      ]
     },
     "execution_count": 11,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "treatment_assay.graph"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[('AT0-S1-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S1-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S1-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S1-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S1-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S1-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S2-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S2-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S2-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S2-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S2-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S2-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S3-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S3-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S3-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S3-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S3-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S3-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S4-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S4-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S4-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S4-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S4-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S4-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S5-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S5-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S5-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S5-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S5-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S5-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S6-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S6-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S6-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S6-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S6-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S6-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S7-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S7-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S7-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S7-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S7-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S7-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S8-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S8-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S8-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S8-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S8-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S8-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S9-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S9-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S9-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S9-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S9-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S9-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S10-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S10-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S10-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S10-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S10-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S10-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S11-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S11-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S11-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S11-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S11-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S11-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S12-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S12-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S12-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S12-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S12-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S12-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S13-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S13-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S13-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S13-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S13-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S13-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S14-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S14-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S14-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S14-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S14-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S14-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S15-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S15-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S15-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S15-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S15-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S15-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S16-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S16-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S16-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S16-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S16-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S16-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S17-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S17-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S17-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S17-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S17-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S17-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S18-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S18-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S18-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S18-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S18-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S18-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S19-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S19-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S19-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S19-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S19-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S19-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S20-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S20-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S20-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S20-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S20-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S20-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S21-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S21-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S21-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S21-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S21-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S21-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S22-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S22-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S22-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S22-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S22-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S22-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S23-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S23-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S23-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S23-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S23-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S23-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S24-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S24-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S24-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S24-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S24-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S24-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S25-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S25-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S25-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S25-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S25-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S25-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S26-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S26-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S26-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S26-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S26-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S26-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S27-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S27-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S27-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S27-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S27-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S27-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S28-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S28-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S28-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S28-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S28-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S28-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S29-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S29-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S29-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S29-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S29-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S29-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S30-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S30-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S30-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S30-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S30-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S30-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S31-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S31-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S31-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S31-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S31-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S31-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S32-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S32-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S32-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S32-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S32-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S32-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S33-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S33-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S33-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S33-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S33-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S33-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S34-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S34-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S34-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S34-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S34-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S34-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S35-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S35-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S35-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S35-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S35-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S35-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S36-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S36-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S36-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S36-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S36-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S36-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S37-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S37-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S37-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S37-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S37-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S37-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S38-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S38-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S38-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S38-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S38-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S38-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S39-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S39-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S39-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S39-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S39-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S39-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S40-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S40-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S40-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S40-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S40-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S40-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S41-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S41-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S41-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S41-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S41-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S41-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S42-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S42-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S42-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S42-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S42-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S42-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S43-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S43-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S43-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S43-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S43-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S43-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S44-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S44-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S44-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S44-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S44-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S44-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S45-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S45-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S45-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S45-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S45-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S45-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S46-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S46-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S46-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S46-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S46-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S46-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S47-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S47-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S47-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S47-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S47-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S47-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S48-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S48-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S48-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S48-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S48-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S48-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S49-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S49-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S49-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S49-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S49-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S49-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S50-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S50-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S50-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S50-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S50-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S50-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S51-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S51-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S51-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S51-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S51-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S51-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S52-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S52-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S52-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S52-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S52-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S52-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S53-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S53-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S53-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S53-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S53-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S53-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S54-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S54-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S54-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S54-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S54-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S54-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S55-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S55-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S55-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S55-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S55-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S55-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S56-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S56-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S56-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S56-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S56-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S56-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S57-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S57-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S57-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S57-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S57-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S57-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S58-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S58-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S58-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S58-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S58-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S58-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S59-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S59-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S59-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S59-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S59-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S59-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S60-assay0---extraction-Acquisition-R1',\n",
       "  None,\n",
       "  'AT0-S60-assay0---nmr-spectroscopy-Acquisition-R2'),\n",
       " ('AT0-S60-assay0---nmr-spectroscopy-Acquisition-R1',\n",
       "  'AT0-S60-assay0---extraction-Acquisition-R1',\n",
       "  None),\n",
       " ('AT0-S60-assay0---nmr-spectroscopy-Acquisition-R2',\n",
       "  'AT0-S60-assay0---extraction-Acquisition-R1',\n",
       "  None)]"
      ]
     },
     "execution_count": 12,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "[(process.name, getattr(process.prev_process, 'name', None), getattr(process.next_process, 'name', None)) for process in treatment_assay.process_sequence]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {},
   "outputs": [],
   "source": [
    "a_graph = treatment_assay.graph"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "360"
      ]
     },
     "execution_count": 14,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(a_graph.nodes)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [],
   "source": [
    "isa_investigation = Investigation(studies=[study])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 24,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "2021-12-03 16:20:00,430 [INFO]: isatab.py(_all_end_to_end_paths:1131) >> [0]\n",
      "2021-12-03 16:20:00,520 [WARNING]: isatab.py(write_study_table_files:1194) >> [2, 1, 0, 4, 3, 6, 5, 8, 7, 10, 9, 12, 11, 14, 13, 16, 15, 18, 17, 20, 19, 22, 21, 24, 23, 26, 25, 28, 27, 30, 29, 32, 31, 34, 33, 36, 35, 38, 37, 40, 39, 42, 41, 44, 43, 46, 45, 48, 47, 50, 49, 52, 51, 54, 53, 56, 55, 58, 57, 60, 59, 62, 61, 64, 63, 66, 65, 68, 67, 70, 69, 72, 71, 74, 73, 76, 75, 78, 77, 80, 79, 82, 81, 84, 83, 86, 85, 88, 87, 90, 89, 92, 91, 94, 93, 96, 95, 98, 97, 100, 99, 102, 101, 104, 103, 106, 105, 108, 107, 110, 109, 112, 111, 114, 113, 116, 115, 118, 117, 120, 119, 122, 121, 124, 123, 126, 125, 128, 127, 130, 129, 132, 131, 134, 133, 136, 135, 138, 137, 140, 139, 142, 141, 144, 143, 146, 145, 148, 147, 150, 149, 152, 151, 154, 153, 156, 155, 158, 157, 160, 159, 162, 161, 164, 163, 166, 165, 168, 167, 170, 169, 172, 171, 174, 173, 176, 175, 178, 177, 180, 179, 182, 181, 184, 183, 186, 185, 188, 187, 190, 189, 192, 191, 194, 193, 196, 195, 198, 197, 200, 199, 202, 201, 204, 203, 206, 205, 208, 207, 210, 209, 212, 211, 214, 213, 216, 215, 218, 217, 220, 219, 222, 221, 224, 223, 226, 225, 228, 227, 230, 229, 232, 231, 234, 233, 236, 235, 238, 237, 240, 239]\n",
      "2021-12-03 16:20:00,523 [INFO]: isatab.py(_longest_path_and_attrs:1091) >> [[0, 2, 1], [0, 4, 3], [0, 6, 5], [0, 8, 7], [0, 10, 9], [0, 12, 11], [0, 14, 13], [0, 16, 15], [0, 18, 17], [0, 20, 19], [0, 22, 21], [0, 24, 23], [0, 26, 25], [0, 28, 27], [0, 30, 29], [0, 32, 31], [0, 34, 33], [0, 36, 35], [0, 38, 37], [0, 40, 39], [0, 42, 41], [0, 44, 43], [0, 46, 45], [0, 48, 47], [0, 50, 49], [0, 52, 51], [0, 54, 53], [0, 56, 55], [0, 58, 57], [0, 60, 59], [0, 62, 61], [0, 64, 63], [0, 66, 65], [0, 68, 67], [0, 70, 69], [0, 72, 71], [0, 74, 73], [0, 76, 75], [0, 78, 77], [0, 80, 79], [0, 82, 81], [0, 84, 83], [0, 86, 85], [0, 88, 87], [0, 90, 89], [0, 92, 91], [0, 94, 93], [0, 96, 95], [0, 98, 97], [0, 100, 99], [0, 102, 101], [0, 104, 103], [0, 106, 105], [0, 108, 107], [0, 110, 109], [0, 112, 111], [0, 114, 113], [0, 116, 115], [0, 118, 117], [0, 120, 119], [0, 122, 121], [0, 124, 123], [0, 126, 125], [0, 128, 127], [0, 130, 129], [0, 132, 131], [0, 134, 133], [0, 136, 135], [0, 138, 137], [0, 140, 139], [0, 142, 141], [0, 144, 143], [0, 146, 145], [0, 148, 147], [0, 150, 149], [0, 152, 151], [0, 154, 153], [0, 156, 155], [0, 158, 157], [0, 160, 159], [0, 162, 161], [0, 164, 163], [0, 166, 165], [0, 168, 167], [0, 170, 169], [0, 172, 171], [0, 174, 173], [0, 176, 175], [0, 178, 177], [0, 180, 179], [0, 182, 181], [0, 184, 183], [0, 186, 185], [0, 188, 187], [0, 190, 189], [0, 192, 191], [0, 194, 193], [0, 196, 195], [0, 198, 197], [0, 200, 199], [0, 202, 201], [0, 204, 203], [0, 206, 205], [0, 208, 207], [0, 210, 209], [0, 212, 211], [0, 214, 213], [0, 216, 215], [0, 218, 217], [0, 220, 219], [0, 222, 221], [0, 224, 223], [0, 226, 225], [0, 228, 227], [0, 230, 229], [0, 232, 231], [0, 234, 233], [0, 236, 235], [0, 238, 237], [0, 240, 239]]\n",
      "2021-12-03 16:20:01,546 [INFO]: isatab.py(_all_end_to_end_paths:1131) >> [121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159, 161, 163, 165, 167, 169, 171, 173, 175, 177, 179, 181, 183, 185, 187, 189, 191, 193, 195, 197, 199, 201, 203, 205, 207, 209, 211, 213, 215, 217, 219, 221, 223, 225, 227, 229, 231, 233, 235, 237, 239]\n",
      "2021-12-03 16:20:01,550 [INFO]: isatab.py(_longest_path_and_attrs:1091) >> [[121, 241, 242, 243], [121, 241, 245, 246], [123, 248, 249, 250], [123, 248, 252, 253], [125, 255, 256, 257], [125, 255, 259, 260], [127, 262, 263, 264], [127, 262, 266, 267], [129, 269, 270, 271], [129, 269, 273, 274], [131, 276, 277, 278], [131, 276, 280, 281], [133, 283, 287, 288], [133, 283, 284, 285], [135, 290, 291, 292], [135, 290, 294, 295], [137, 297, 298, 299], [137, 297, 301, 302], [139, 304, 305, 306], [139, 304, 308, 309], [141, 311, 312, 313], [141, 311, 315, 316], [143, 318, 319, 320], [143, 318, 322, 323], [145, 325, 326, 327], [145, 325, 329, 330], [147, 332, 333, 334], [147, 332, 336, 337], [149, 339, 340, 341], [149, 339, 343, 344], [151, 346, 347, 348], [151, 346, 350, 351], [153, 353, 354, 355], [153, 353, 357, 358], [155, 360, 361, 362], [155, 360, 364, 365], [157, 367, 368, 369], [157, 367, 371, 372], [159, 374, 375, 376], [159, 374, 378, 379], [161, 381, 385, 386], [161, 381, 382, 383], [163, 388, 389, 390], [163, 388, 392, 393], [165, 395, 396, 397], [165, 395, 399, 400], [167, 402, 403, 404], [167, 402, 406, 407], [169, 409, 410, 411], [169, 409, 413, 414], [171, 416, 417, 418], [171, 416, 420, 421], [173, 423, 424, 425], [173, 423, 427, 428], [175, 430, 431, 432], [175, 430, 434, 435], [177, 437, 438, 439], [177, 437, 441, 442], [179, 444, 448, 449], [179, 444, 445, 446], [181, 451, 452, 453], [181, 451, 455, 456], [183, 458, 459, 460], [183, 458, 462, 463], [185, 465, 466, 467], [185, 465, 469, 470], [187, 472, 473, 474], [187, 472, 476, 477], [189, 479, 480, 481], [189, 479, 483, 484], [191, 486, 487, 488], [191, 486, 490, 491], [193, 493, 494, 495], [193, 493, 497, 498], [195, 500, 501, 502], [195, 500, 504, 505], [197, 507, 511, 512], [197, 507, 508, 509], [199, 514, 515, 516], [199, 514, 518, 519], [201, 521, 522, 523], [201, 521, 525, 526], [203, 528, 529, 530], [203, 528, 532, 533], [205, 535, 536, 537], [205, 535, 539, 540], [207, 542, 543, 544], [207, 542, 546, 547], [209, 549, 550, 551], [209, 549, 553, 554], [211, 556, 557, 558], [211, 556, 560, 561], [213, 563, 564, 565], [213, 563, 567, 568], [215, 570, 571, 572], [215, 570, 574, 575], [217, 577, 578, 579], [217, 577, 581, 582], [219, 584, 585, 586], [219, 584, 588, 589], [221, 591, 592, 593], [221, 591, 595, 596], [223, 598, 599, 600], [223, 598, 602, 603], [225, 605, 609, 610], [225, 605, 606, 607], [227, 612, 613, 614], [227, 612, 616, 617], [229, 619, 620, 621], [229, 619, 623, 624], [231, 626, 627, 628], [231, 626, 630, 631], [233, 633, 634, 635], [233, 633, 637, 638], [235, 640, 641, 642], [235, 640, 644, 645], [237, 647, 648, 649], [237, 647, 651, 652], [239, 654, 655, 656], [239, 654, 658, 659]]\n",
      "2021-12-03 16:20:01,554 [INFO]: isatab.py(_longest_path_and_attrs:1091) >> [[121, 241, 242, 243], [121, 241, 245, 246], [123, 248, 249, 250], [123, 248, 252, 253], [125, 255, 256, 257], [125, 255, 259, 260], [127, 262, 263, 264], [127, 262, 266, 267], [129, 269, 270, 271], [129, 269, 273, 274], [131, 276, 277, 278], [131, 276, 280, 281], [133, 283, 287, 288], [133, 283, 284, 285], [135, 290, 291, 292], [135, 290, 294, 295], [137, 297, 298, 299], [137, 297, 301, 302], [139, 304, 305, 306], [139, 304, 308, 309], [141, 311, 312, 313], [141, 311, 315, 316], [143, 318, 319, 320], [143, 318, 322, 323], [145, 325, 326, 327], [145, 325, 329, 330], [147, 332, 333, 334], [147, 332, 336, 337], [149, 339, 340, 341], [149, 339, 343, 344], [151, 346, 347, 348], [151, 346, 350, 351], [153, 353, 354, 355], [153, 353, 357, 358], [155, 360, 361, 362], [155, 360, 364, 365], [157, 367, 368, 369], [157, 367, 371, 372], [159, 374, 375, 376], [159, 374, 378, 379], [161, 381, 385, 386], [161, 381, 382, 383], [163, 388, 389, 390], [163, 388, 392, 393], [165, 395, 396, 397], [165, 395, 399, 400], [167, 402, 403, 404], [167, 402, 406, 407], [169, 409, 410, 411], [169, 409, 413, 414], [171, 416, 417, 418], [171, 416, 420, 421], [173, 423, 424, 425], [173, 423, 427, 428], [175, 430, 431, 432], [175, 430, 434, 435], [177, 437, 438, 439], [177, 437, 441, 442], [179, 444, 448, 449], [179, 444, 445, 446], [181, 451, 452, 453], [181, 451, 455, 456], [183, 458, 459, 460], [183, 458, 462, 463], [185, 465, 466, 467], [185, 465, 469, 470], [187, 472, 473, 474], [187, 472, 476, 477], [189, 479, 480, 481], [189, 479, 483, 484], [191, 486, 487, 488], [191, 486, 490, 491], [193, 493, 494, 495], [193, 493, 497, 498], [195, 500, 501, 502], [195, 500, 504, 505], [197, 507, 511, 512], [197, 507, 508, 509], [199, 514, 515, 516], [199, 514, 518, 519], [201, 521, 522, 523], [201, 521, 525, 526], [203, 528, 529, 530], [203, 528, 532, 533], [205, 535, 536, 537], [205, 535, 539, 540], [207, 542, 543, 544], [207, 542, 546, 547], [209, 549, 550, 551], [209, 549, 553, 554], [211, 556, 557, 558], [211, 556, 560, 561], [213, 563, 564, 565], [213, 563, 567, 568], [215, 570, 571, 572], [215, 570, 574, 575], [217, 577, 578, 579], [217, 577, 581, 582], [219, 584, 585, 586], [219, 584, 588, 589], [221, 591, 592, 593], [221, 591, 595, 596], [223, 598, 599, 600], [223, 598, 602, 603], [225, 605, 609, 610], [225, 605, 606, 607], [227, 612, 613, 614], [227, 612, 616, 617], [229, 619, 620, 621], [229, 619, 623, 624], [231, 626, 627, 628], [231, 626, 630, 631], [233, 633, 634, 635], [233, 633, 637, 638], [235, 640, 641, 642], [235, 640, 644, 645], [237, 647, 648, 649], [237, 647, 651, 652], [239, 654, 655, 656], [239, 654, 658, 659]]\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "2021-12-03 16:20:05,844 [INFO]: isatab.py(_all_end_to_end_paths:1131) >> [1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119]\n",
      "2021-12-03 16:20:05,869 [INFO]: isatab.py(_longest_path_and_attrs:1091) >> [[1, 661, 662, 663, 664, 665], [1, 661, 662, 663, 664, 667], [1, 661, 662, 663, 664, 669], [1, 661, 662, 663, 664, 671], [1, 661, 673, 674, 675, 676], [1, 661, 673, 674, 675, 678], [1, 661, 673, 674, 675, 680], [1, 661, 673, 674, 675, 682], [3, 684, 696, 697, 698, 705], [3, 684, 685, 686, 687, 688], [3, 684, 685, 686, 687, 690], [3, 684, 685, 686, 687, 692], [3, 684, 685, 686, 687, 694], [3, 684, 696, 697, 698, 699], [3, 684, 696, 697, 698, 701], [3, 684, 696, 697, 698, 703], [5, 707, 708, 709, 710, 711], [5, 707, 708, 709, 710, 713], [5, 707, 708, 709, 710, 715], [5, 707, 708, 709, 710, 717], [5, 707, 719, 720, 721, 722], [5, 707, 719, 720, 721, 724], [5, 707, 719, 720, 721, 726], [5, 707, 719, 720, 721, 728], [7, 730, 731, 732, 733, 734], [7, 730, 731, 732, 733, 736], [7, 730, 731, 732, 733, 738], [7, 730, 731, 732, 733, 740], [7, 730, 742, 743, 744, 745], [7, 730, 742, 743, 744, 747], [7, 730, 742, 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      "2021-12-03 16:20:05,881 [INFO]: isatab.py(_longest_path_and_attrs:1091) >> [[1, 661, 662, 663, 664, 665], [1, 661, 662, 663, 664, 667], [1, 661, 662, 663, 664, 669], [1, 661, 662, 663, 664, 671], [1, 661, 673, 674, 675, 676], [1, 661, 673, 674, 675, 678], [1, 661, 673, 674, 675, 680], [1, 661, 673, 674, 675, 682], [3, 684, 696, 697, 698, 705], [3, 684, 685, 686, 687, 688], [3, 684, 685, 686, 687, 690], [3, 684, 685, 686, 687, 692], [3, 684, 685, 686, 687, 694], [3, 684, 696, 697, 698, 699], [3, 684, 696, 697, 698, 701], [3, 684, 696, 697, 698, 703], [5, 707, 708, 709, 710, 711], [5, 707, 708, 709, 710, 713], [5, 707, 708, 709, 710, 715], [5, 707, 708, 709, 710, 717], [5, 707, 719, 720, 721, 722], [5, 707, 719, 720, 721, 724], [5, 707, 719, 720, 721, 726], [5, 707, 719, 720, 721, 728], [7, 730, 731, 732, 733, 734], [7, 730, 731, 732, 733, 736], [7, 730, 731, 732, 733, 738], [7, 730, 731, 732, 733, 740], [7, 730, 742, 743, 744, 745], [7, 730, 742, 743, 744, 747], [7, 730, 742, 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1972, 1984, 1985, 1986, 1989], [115, 1972, 1984, 1985, 1986, 1991], [115, 1972, 1984, 1985, 1986, 1993], [115, 1972, 1973, 1974, 1975, 1976], [115, 1972, 1973, 1974, 1975, 1978], [115, 1972, 1973, 1974, 1975, 1980], [115, 1972, 1973, 1974, 1975, 1982], [117, 1995, 1996, 1997, 1998, 1999], [117, 1995, 1996, 1997, 1998, 2001], [117, 1995, 1996, 1997, 1998, 2003], [117, 1995, 1996, 1997, 1998, 2005], [117, 1995, 2007, 2008, 2009, 2010], [117, 1995, 2007, 2008, 2009, 2012], [117, 1995, 2007, 2008, 2009, 2014], [117, 1995, 2007, 2008, 2009, 2016], [119, 2018, 2019, 2020, 2021, 2022], [119, 2018, 2019, 2020, 2021, 2024], [119, 2018, 2019, 2020, 2021, 2026], [119, 2018, 2019, 2020, 2021, 2028], [119, 2018, 2030, 2031, 2032, 2033], [119, 2018, 2030, 2031, 2032, 2035], [119, 2018, 2030, 2031, 2032, 2037], [119, 2018, 2030, 2031, 2032, 2039]]\n"
     ]
    }
   ],
   "source": [
    "isa_tables = dumpdf(isa_investigation)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "metadata": {},
   "outputs": [],
   "source": [
    "#[type(x) for x in study.assays[0].graph.nodes()]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "metadata": {},
   "outputs": [],
   "source": [
    "#[(getattr(el, 'name', None), type(el))for el in treatment_assay.graph.nodes()]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {},
   "outputs": [],
   "source": [
    "from isatools.model import _build_assay_graph"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "metadata": {},
   "outputs": [],
   "source": [
    "gph = _build_assay_graph(treatment_assay.process_sequence)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 25,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['s_study_01.txt',\n",
       " 'a_AT0_metabolite-profiling_mass-spectrometry.txt',\n",
       " 'a_AT0_metabolite-profiling_nmr-spectroscopy.txt']"
      ]
     },
     "execution_count": 25,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "[key for key in isa_tables.keys()]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 26,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
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       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Source Name</th>\n",
       "      <th>Characteristics[Study Subject]</th>\n",
       "      <th>Term Source REF</th>\n",
       "      <th>Term Accession Number</th>\n",
       "      <th>Protocol REF</th>\n",
       "      <th>Parameter Value[Sampling order]</th>\n",
       "      <th>Parameter Value[Study cell]</th>\n",
       "      <th>Date</th>\n",
       "      <th>Performer</th>\n",
       "      <th>Sample Name</th>\n",
       "      <th>Characteristics[organism part]</th>\n",
       "      <th>Comment[study step with treatment]</th>\n",
       "      <th>Factor Value[Sequence Order]</th>\n",
       "      <th>Factor Value[AGENT]</th>\n",
       "      <th>Factor Value[DURATION]</th>\n",
       "      <th>Unit</th>\n",
       "      <th>Factor Value[INTENSITY]</th>\n",
       "      <th>Unit.1</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>GRP1_SBJ05</td>\n",
       "      <td>Human</td>\n",
       "      <td>NCIT</td>\n",
       "      <td>http://purl.obolibrary.org/obo/NCIT_C14225</td>\n",
       "      <td>sample collection</td>\n",
       "      <td>001</td>\n",
       "      <td>screen</td>\n",
       "      <td>2021-12-03</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>GRP1_SBJ02_screen_SMP-blood-1</td>\n",
       "      <td>blood</td>\n",
       "      <td>NO</td>\n",
       "      <td>0</td>\n",
       "      <td></td>\n",
       "      <td>100.0</td>\n",
       "      <td>day</td>\n",
       "      <td></td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>GRP1_SBJ05</td>\n",
       "      <td>Human</td>\n",
       "      <td>NCIT</td>\n",
       "      <td>http://purl.obolibrary.org/obo/NCIT_C14225</td>\n",
       "      <td>sample collection</td>\n",
       "      <td>088</td>\n",
       "      <td>SINGLE TREATMENT FIRST</td>\n",
       "      <td>2021-12-03</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1</td>\n",
       "      <td>heart</td>\n",
       "      <td>YES</td>\n",
       "      <td>2</td>\n",
       "      <td>nitroglycerin</td>\n",
       "      <td>100.0</td>\n",
       "      <td>s</td>\n",
       "      <td>5.0</td>\n",
       "      <td>kg/m^3</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>GRP1_SBJ05</td>\n",
       "      <td>Human</td>\n",
       "      <td>NCIT</td>\n",
       "      <td>http://purl.obolibrary.org/obo/NCIT_C14225</td>\n",
       "      <td>sample collection</td>\n",
       "      <td>087</td>\n",
       "      <td>SINGLE TREATMENT FIRST</td>\n",
       "      <td>2021-12-03</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-heart-1</td>\n",
       "      <td>heart</td>\n",
       "      <td>YES</td>\n",
       "      <td>2</td>\n",
       "      <td>nitroglycerin</td>\n",
       "      <td>100.0</td>\n",
       "      <td>s</td>\n",
       "      <td>5.0</td>\n",
       "      <td>kg/m^3</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>GRP1_SBJ05</td>\n",
       "      <td>Human</td>\n",
       "      <td>NCIT</td>\n",
       "      <td>http://purl.obolibrary.org/obo/NCIT_C14225</td>\n",
       "      <td>sample collection</td>\n",
       "      <td>086</td>\n",
       "      <td>SINGLE TREATMENT FIRST</td>\n",
       "      <td>2021-12-03</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-heart-1</td>\n",
       "      <td>heart</td>\n",
       "      <td>YES</td>\n",
       "      <td>2</td>\n",
       "      <td>nitroglycerin</td>\n",
       "      <td>100.0</td>\n",
       "      <td>s</td>\n",
       "      <td>5.0</td>\n",
       "      <td>kg/m^3</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>GRP1_SBJ05</td>\n",
       "      <td>Human</td>\n",
       "      <td>NCIT</td>\n",
       "      <td>http://purl.obolibrary.org/obo/NCIT_C14225</td>\n",
       "      <td>sample collection</td>\n",
       "      <td>085</td>\n",
       "      <td>SINGLE TREATMENT FIRST</td>\n",
       "      <td>2021-12-03</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-heart-1</td>\n",
       "      <td>heart</td>\n",
       "      <td>YES</td>\n",
       "      <td>2</td>\n",
       "      <td>nitroglycerin</td>\n",
       "      <td>100.0</td>\n",
       "      <td>s</td>\n",
       "      <td>5.0</td>\n",
       "      <td>kg/m^3</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>115</th>\n",
       "      <td>GRP1_SBJ05</td>\n",
       "      <td>Human</td>\n",
       "      <td>NCIT</td>\n",
       "      <td>http://purl.obolibrary.org/obo/NCIT_C14225</td>\n",
       "      <td>sample collection</td>\n",
       "      <td>034</td>\n",
       "      <td>run-in</td>\n",
       "      <td>2021-12-03</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>GRP1_SBJ04_run-in_SMP-blood-1</td>\n",
       "      <td>blood</td>\n",
       "      <td>NO</td>\n",
       "      <td>1</td>\n",
       "      <td></td>\n",
       "      <td>30.0</td>\n",
       "      <td>day</td>\n",
       "      <td></td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>116</th>\n",
       "      <td>GRP1_SBJ05</td>\n",
       "      <td>Human</td>\n",
       "      <td>NCIT</td>\n",
       "      <td>http://purl.obolibrary.org/obo/NCIT_C14225</td>\n",
       "      <td>sample collection</td>\n",
       "      <td>033</td>\n",
       "      <td>run-in</td>\n",
       "      <td>2021-12-03</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>GRP1_SBJ03_run-in_SMP-blood-1</td>\n",
       "      <td>blood</td>\n",
       "      <td>NO</td>\n",
       "      <td>1</td>\n",
       "      <td></td>\n",
       "      <td>30.0</td>\n",
       "      <td>day</td>\n",
       "      <td></td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>117</th>\n",
       "      <td>GRP1_SBJ05</td>\n",
       "      <td>Human</td>\n",
       "      <td>NCIT</td>\n",
       "      <td>http://purl.obolibrary.org/obo/NCIT_C14225</td>\n",
       "      <td>sample collection</td>\n",
       "      <td>032</td>\n",
       "      <td>run-in</td>\n",
       "      <td>2021-12-03</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>GRP1_SBJ09_run-in_SMP-blood-1</td>\n",
       "      <td>blood</td>\n",
       "      <td>NO</td>\n",
       "      <td>1</td>\n",
       "      <td></td>\n",
       "      <td>30.0</td>\n",
       "      <td>day</td>\n",
       "      <td></td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>118</th>\n",
       "      <td>GRP1_SBJ05</td>\n",
       "      <td>Human</td>\n",
       "      <td>NCIT</td>\n",
       "      <td>http://purl.obolibrary.org/obo/NCIT_C14225</td>\n",
       "      <td>sample collection</td>\n",
       "      <td>119</td>\n",
       "      <td>follow-up</td>\n",
       "      <td>2021-12-03</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>GRP1_SBJ06_follow-up_SMP-heart-1</td>\n",
       "      <td>heart</td>\n",
       "      <td>NO</td>\n",
       "      <td>3</td>\n",
       "      <td></td>\n",
       "      <td>1830.0</td>\n",
       "      <td>day</td>\n",
       "      <td></td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>119</th>\n",
       "      <td>GRP1_SBJ05</td>\n",
       "      <td>Human</td>\n",
       "      <td>NCIT</td>\n",
       "      <td>http://purl.obolibrary.org/obo/NCIT_C14225</td>\n",
       "      <td>sample collection</td>\n",
       "      <td>120</td>\n",
       "      <td>follow-up</td>\n",
       "      <td>2021-12-03</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>GRP1_SBJ05_follow-up_SMP-heart-1</td>\n",
       "      <td>heart</td>\n",
       "      <td>NO</td>\n",
       "      <td>3</td>\n",
       "      <td></td>\n",
       "      <td>1830.0</td>\n",
       "      <td>day</td>\n",
       "      <td></td>\n",
       "      <td></td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>120 rows × 18 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "    Source Name Characteristics[Study Subject] Term Source REF  \\\n",
       "0    GRP1_SBJ05                          Human            NCIT   \n",
       "1    GRP1_SBJ05                          Human            NCIT   \n",
       "2    GRP1_SBJ05                          Human            NCIT   \n",
       "3    GRP1_SBJ05                          Human            NCIT   \n",
       "4    GRP1_SBJ05                          Human            NCIT   \n",
       "..          ...                            ...             ...   \n",
       "115  GRP1_SBJ05                          Human            NCIT   \n",
       "116  GRP1_SBJ05                          Human            NCIT   \n",
       "117  GRP1_SBJ05                          Human            NCIT   \n",
       "118  GRP1_SBJ05                          Human            NCIT   \n",
       "119  GRP1_SBJ05                          Human            NCIT   \n",
       "\n",
       "                          Term Accession Number       Protocol REF  \\\n",
       "0    http://purl.obolibrary.org/obo/NCIT_C14225  sample collection   \n",
       "1    http://purl.obolibrary.org/obo/NCIT_C14225  sample collection   \n",
       "2    http://purl.obolibrary.org/obo/NCIT_C14225  sample collection   \n",
       "3    http://purl.obolibrary.org/obo/NCIT_C14225  sample collection   \n",
       "4    http://purl.obolibrary.org/obo/NCIT_C14225  sample collection   \n",
       "..                                          ...                ...   \n",
       "115  http://purl.obolibrary.org/obo/NCIT_C14225  sample collection   \n",
       "116  http://purl.obolibrary.org/obo/NCIT_C14225  sample collection   \n",
       "117  http://purl.obolibrary.org/obo/NCIT_C14225  sample collection   \n",
       "118  http://purl.obolibrary.org/obo/NCIT_C14225  sample collection   \n",
       "119  http://purl.obolibrary.org/obo/NCIT_C14225  sample collection   \n",
       "\n",
       "    Parameter Value[Sampling order] Parameter Value[Study cell]        Date  \\\n",
       "0                               001                      screen  2021-12-03   \n",
       "1                               088      SINGLE TREATMENT FIRST  2021-12-03   \n",
       "2                               087      SINGLE TREATMENT FIRST  2021-12-03   \n",
       "3                               086      SINGLE TREATMENT FIRST  2021-12-03   \n",
       "4                               085      SINGLE TREATMENT FIRST  2021-12-03   \n",
       "..                              ...                         ...         ...   \n",
       "115                             034                      run-in  2021-12-03   \n",
       "116                             033                      run-in  2021-12-03   \n",
       "117                             032                      run-in  2021-12-03   \n",
       "118                             119                   follow-up  2021-12-03   \n",
       "119                             120                   follow-up  2021-12-03   \n",
       "\n",
       "    Performer                                    Sample Name  \\\n",
       "0     Unknown                  GRP1_SBJ02_screen_SMP-blood-1   \n",
       "1     Unknown  GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1   \n",
       "2     Unknown  GRP1_SBJ10_SINGLE-TREATMENT-FIRST_SMP-heart-1   \n",
       "3     Unknown  GRP1_SBJ08_SINGLE-TREATMENT-FIRST_SMP-heart-1   \n",
       "4     Unknown  GRP1_SBJ07_SINGLE-TREATMENT-FIRST_SMP-heart-1   \n",
       "..        ...                                            ...   \n",
       "115   Unknown                  GRP1_SBJ04_run-in_SMP-blood-1   \n",
       "116   Unknown                  GRP1_SBJ03_run-in_SMP-blood-1   \n",
       "117   Unknown                  GRP1_SBJ09_run-in_SMP-blood-1   \n",
       "118   Unknown               GRP1_SBJ06_follow-up_SMP-heart-1   \n",
       "119   Unknown               GRP1_SBJ05_follow-up_SMP-heart-1   \n",
       "\n",
       "    Characteristics[organism part] Comment[study step with treatment]  \\\n",
       "0                            blood                                 NO   \n",
       "1                            heart                                YES   \n",
       "2                            heart                                YES   \n",
       "3                            heart                                YES   \n",
       "4                            heart                                YES   \n",
       "..                             ...                                ...   \n",
       "115                          blood                                 NO   \n",
       "116                          blood                                 NO   \n",
       "117                          blood                                 NO   \n",
       "118                          heart                                 NO   \n",
       "119                          heart                                 NO   \n",
       "\n",
       "    Factor Value[Sequence Order] Factor Value[AGENT] Factor Value[DURATION]  \\\n",
       "0                              0                                      100.0   \n",
       "1                              2       nitroglycerin                  100.0   \n",
       "2                              2       nitroglycerin                  100.0   \n",
       "3                              2       nitroglycerin                  100.0   \n",
       "4                              2       nitroglycerin                  100.0   \n",
       "..                           ...                 ...                    ...   \n",
       "115                            1                                       30.0   \n",
       "116                            1                                       30.0   \n",
       "117                            1                                       30.0   \n",
       "118                            3                                     1830.0   \n",
       "119                            3                                     1830.0   \n",
       "\n",
       "    Unit Factor Value[INTENSITY]  Unit.1  \n",
       "0    day                                  \n",
       "1      s                     5.0  kg/m^3  \n",
       "2      s                     5.0  kg/m^3  \n",
       "3      s                     5.0  kg/m^3  \n",
       "4      s                     5.0  kg/m^3  \n",
       "..   ...                     ...     ...  \n",
       "115  day                                  \n",
       "116  day                                  \n",
       "117  day                                  \n",
       "118  day                                  \n",
       "119  day                                  \n",
       "\n",
       "[120 rows x 18 columns]"
      ]
     },
     "execution_count": 26,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "isa_tables['s_study_01.txt']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 27,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
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       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Sample Name</th>\n",
       "      <th>Comment[study step with treatment]</th>\n",
       "      <th>Protocol REF</th>\n",
       "      <th>Performer</th>\n",
       "      <th>Extract Name</th>\n",
       "      <th>Characteristics[extract type]</th>\n",
       "      <th>Protocol REF.1</th>\n",
       "      <th>Parameter Value[instrument]</th>\n",
       "      <th>Parameter Value[acquisition_mode]</th>\n",
       "      <th>Parameter Value[pulse_sequence]</th>\n",
       "      <th>Performer.1</th>\n",
       "      <th>Raw Data File</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-blood-1</td>\n",
       "      <td>YES</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S8-Extract-R2</td>\n",
       "      <td>supernatant</td>\n",
       "      <td>assay0 - nmr spectroscopy</td>\n",
       "      <td>Bruker AvanceII 1 GHz</td>\n",
       "      <td>1D 13C NMR</td>\n",
       "      <td>CPMG</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S8-raw_spectral_data_file-R2-</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-blood-1</td>\n",
       "      <td>YES</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S8-Extract-R1</td>\n",
       "      <td>pellet</td>\n",
       "      <td>assay0 - nmr spectroscopy</td>\n",
       "      <td>Bruker AvanceII 1 GHz</td>\n",
       "      <td>1D 13C NMR</td>\n",
       "      <td>CPMG</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S8-raw_spectral_data_file-R1-</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1</td>\n",
       "      <td>YES</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S28-Extract-R1</td>\n",
       "      <td>pellet</td>\n",
       "      <td>assay0 - nmr spectroscopy</td>\n",
       "      <td>Bruker AvanceII 1 GHz</td>\n",
       "      <td>1D 13C NMR</td>\n",
       "      <td>CPMG</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S28-raw_spectral_data_file-R1-</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1</td>\n",
       "      <td>YES</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S28-Extract-R2</td>\n",
       "      <td>supernatant</td>\n",
       "      <td>assay0 - nmr spectroscopy</td>\n",
       "      <td>Bruker AvanceII 1 GHz</td>\n",
       "      <td>1D 13C NMR</td>\n",
       "      <td>CPMG</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S28-raw_spectral_data_file-R2-</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-liver-1</td>\n",
       "      <td>YES</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S18-Extract-R2</td>\n",
       "      <td>supernatant</td>\n",
       "      <td>assay0 - nmr spectroscopy</td>\n",
       "      <td>Bruker AvanceII 1 GHz</td>\n",
       "      <td>1D 13C NMR</td>\n",
       "      <td>CPMG</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S18-raw_spectral_data_file-R2-</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>115</th>\n",
       "      <td>GRP1_SBJ10_follow-up_SMP-blood-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S37-Extract-R2</td>\n",
       "      <td>supernatant</td>\n",
       "      <td>assay0 - nmr spectroscopy</td>\n",
       "      <td>Bruker AvanceII 1 GHz</td>\n",
       "      <td>1D 13C NMR</td>\n",
       "      <td>CPMG</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S37-raw_spectral_data_file-R2-</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>116</th>\n",
       "      <td>GRP1_SBJ10_follow-up_SMP-heart-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S57-Extract-R1</td>\n",
       "      <td>pellet</td>\n",
       "      <td>assay0 - nmr spectroscopy</td>\n",
       "      <td>Bruker AvanceII 1 GHz</td>\n",
       "      <td>1D 13C NMR</td>\n",
       "      <td>CPMG</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S57-raw_spectral_data_file-R1-</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>117</th>\n",
       "      <td>GRP1_SBJ10_follow-up_SMP-heart-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S57-Extract-R2</td>\n",
       "      <td>supernatant</td>\n",
       "      <td>assay0 - nmr spectroscopy</td>\n",
       "      <td>Bruker AvanceII 1 GHz</td>\n",
       "      <td>1D 13C NMR</td>\n",
       "      <td>CPMG</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S57-raw_spectral_data_file-R2-</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>118</th>\n",
       "      <td>GRP1_SBJ10_follow-up_SMP-liver-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S47-Extract-R2</td>\n",
       "      <td>supernatant</td>\n",
       "      <td>assay0 - nmr spectroscopy</td>\n",
       "      <td>Bruker AvanceII 1 GHz</td>\n",
       "      <td>1D 13C NMR</td>\n",
       "      <td>CPMG</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S47-raw_spectral_data_file-R2-</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>119</th>\n",
       "      <td>GRP1_SBJ10_follow-up_SMP-liver-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S47-Extract-R1</td>\n",
       "      <td>pellet</td>\n",
       "      <td>assay0 - nmr spectroscopy</td>\n",
       "      <td>Bruker AvanceII 1 GHz</td>\n",
       "      <td>1D 13C NMR</td>\n",
       "      <td>CPMG</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S47-raw_spectral_data_file-R1-</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>120 rows × 12 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                                       Sample Name  \\\n",
       "0    GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-blood-1   \n",
       "1    GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-blood-1   \n",
       "2    GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1   \n",
       "3    GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-heart-1   \n",
       "4    GRP1_SBJ01_SINGLE-TREATMENT-FIRST_SMP-liver-1   \n",
       "..                                             ...   \n",
       "115               GRP1_SBJ10_follow-up_SMP-blood-1   \n",
       "116               GRP1_SBJ10_follow-up_SMP-heart-1   \n",
       "117               GRP1_SBJ10_follow-up_SMP-heart-1   \n",
       "118               GRP1_SBJ10_follow-up_SMP-liver-1   \n",
       "119               GRP1_SBJ10_follow-up_SMP-liver-1   \n",
       "\n",
       "    Comment[study step with treatment]         Protocol REF Performer  \\\n",
       "0                                  YES  assay0 - extraction   Unknown   \n",
       "1                                  YES  assay0 - extraction   Unknown   \n",
       "2                                  YES  assay0 - extraction   Unknown   \n",
       "3                                  YES  assay0 - extraction   Unknown   \n",
       "4                                  YES  assay0 - extraction   Unknown   \n",
       "..                                 ...                  ...       ...   \n",
       "115                                 NO  assay0 - extraction   Unknown   \n",
       "116                                 NO  assay0 - extraction   Unknown   \n",
       "117                                 NO  assay0 - extraction   Unknown   \n",
       "118                                 NO  assay0 - extraction   Unknown   \n",
       "119                                 NO  assay0 - extraction   Unknown   \n",
       "\n",
       "           Extract Name Characteristics[extract type]  \\\n",
       "0     AT0-S8-Extract-R2                   supernatant   \n",
       "1     AT0-S8-Extract-R1                        pellet   \n",
       "2    AT0-S28-Extract-R1                        pellet   \n",
       "3    AT0-S28-Extract-R2                   supernatant   \n",
       "4    AT0-S18-Extract-R2                   supernatant   \n",
       "..                  ...                           ...   \n",
       "115  AT0-S37-Extract-R2                   supernatant   \n",
       "116  AT0-S57-Extract-R1                        pellet   \n",
       "117  AT0-S57-Extract-R2                   supernatant   \n",
       "118  AT0-S47-Extract-R2                   supernatant   \n",
       "119  AT0-S47-Extract-R1                        pellet   \n",
       "\n",
       "                Protocol REF.1 Parameter Value[instrument]  \\\n",
       "0    assay0 - nmr spectroscopy       Bruker AvanceII 1 GHz   \n",
       "1    assay0 - nmr spectroscopy       Bruker AvanceII 1 GHz   \n",
       "2    assay0 - nmr spectroscopy       Bruker AvanceII 1 GHz   \n",
       "3    assay0 - nmr spectroscopy       Bruker AvanceII 1 GHz   \n",
       "4    assay0 - nmr spectroscopy       Bruker AvanceII 1 GHz   \n",
       "..                         ...                         ...   \n",
       "115  assay0 - nmr spectroscopy       Bruker AvanceII 1 GHz   \n",
       "116  assay0 - nmr spectroscopy       Bruker AvanceII 1 GHz   \n",
       "117  assay0 - nmr spectroscopy       Bruker AvanceII 1 GHz   \n",
       "118  assay0 - nmr spectroscopy       Bruker AvanceII 1 GHz   \n",
       "119  assay0 - nmr spectroscopy       Bruker AvanceII 1 GHz   \n",
       "\n",
       "    Parameter Value[acquisition_mode] Parameter Value[pulse_sequence]  \\\n",
       "0                          1D 13C NMR                            CPMG   \n",
       "1                          1D 13C NMR                            CPMG   \n",
       "2                          1D 13C NMR                            CPMG   \n",
       "3                          1D 13C NMR                            CPMG   \n",
       "4                          1D 13C NMR                            CPMG   \n",
       "..                                ...                             ...   \n",
       "115                        1D 13C NMR                            CPMG   \n",
       "116                        1D 13C NMR                            CPMG   \n",
       "117                        1D 13C NMR                            CPMG   \n",
       "118                        1D 13C NMR                            CPMG   \n",
       "119                        1D 13C NMR                            CPMG   \n",
       "\n",
       "    Performer.1                       Raw Data File  \n",
       "0       Unknown   AT0-S8-raw_spectral_data_file-R2-  \n",
       "1       Unknown   AT0-S8-raw_spectral_data_file-R1-  \n",
       "2       Unknown  AT0-S28-raw_spectral_data_file-R1-  \n",
       "3       Unknown  AT0-S28-raw_spectral_data_file-R2-  \n",
       "4       Unknown  AT0-S18-raw_spectral_data_file-R2-  \n",
       "..          ...                                 ...  \n",
       "115     Unknown  AT0-S37-raw_spectral_data_file-R2-  \n",
       "116     Unknown  AT0-S57-raw_spectral_data_file-R1-  \n",
       "117     Unknown  AT0-S57-raw_spectral_data_file-R2-  \n",
       "118     Unknown  AT0-S47-raw_spectral_data_file-R2-  \n",
       "119     Unknown  AT0-S47-raw_spectral_data_file-R1-  \n",
       "\n",
       "[120 rows x 12 columns]"
      ]
     },
     "execution_count": 27,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "isa_tables['a_AT0_metabolite-profiling_nmr-spectroscopy.txt']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 28,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
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       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>Sample Name</th>\n",
       "      <th>Comment[study step with treatment]</th>\n",
       "      <th>Protocol REF</th>\n",
       "      <th>Performer</th>\n",
       "      <th>Extract Name</th>\n",
       "      <th>Characteristics[extract type]</th>\n",
       "      <th>Protocol REF.1</th>\n",
       "      <th>Parameter Value[derivatization]</th>\n",
       "      <th>Performer.1</th>\n",
       "      <th>Labeled Extract Name</th>\n",
       "      <th>Protocol REF.2</th>\n",
       "      <th>Parameter Value[instrument]</th>\n",
       "      <th>Parameter Value[injection_mode]</th>\n",
       "      <th>Parameter Value[acquisition_mode]</th>\n",
       "      <th>Performer.2</th>\n",
       "      <th>Raw Spectral Data File</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>GRP1_SBJ01_run-in_SMP-blood-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-Extract-R2</td>\n",
       "      <td>lipids</td>\n",
       "      <td>assay0 - derivatization</td>\n",
       "      <td>bis(trimethylsilyl)acetamide</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-LE-R2</td>\n",
       "      <td>assay0 - mass spectrometry</td>\n",
       "      <td>Agilent QTOF</td>\n",
       "      <td>GC</td>\n",
       "      <td>negative mode</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-raw-spectral-data-file-R6</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>GRP1_SBJ01_run-in_SMP-blood-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-Extract-R1</td>\n",
       "      <td>polar fraction</td>\n",
       "      <td>assay0 - derivatization</td>\n",
       "      <td>bis(trimethylsilyl)acetamide</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-LE-R1</td>\n",
       "      <td>assay0 - mass spectrometry</td>\n",
       "      <td>Agilent QTOF</td>\n",
       "      <td>GC</td>\n",
       "      <td>negative mode</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-raw-spectral-data-file-R4</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>GRP1_SBJ01_run-in_SMP-blood-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-Extract-R1</td>\n",
       "      <td>polar fraction</td>\n",
       "      <td>assay0 - derivatization</td>\n",
       "      <td>bis(trimethylsilyl)acetamide</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-LE-R1</td>\n",
       "      <td>assay0 - mass spectrometry</td>\n",
       "      <td>Agilent QTOF</td>\n",
       "      <td>GC</td>\n",
       "      <td>negative mode</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-raw-spectral-data-file-R3</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>GRP1_SBJ01_run-in_SMP-blood-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-Extract-R1</td>\n",
       "      <td>polar fraction</td>\n",
       "      <td>assay0 - derivatization</td>\n",
       "      <td>bis(trimethylsilyl)acetamide</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-LE-R1</td>\n",
       "      <td>assay0 - mass spectrometry</td>\n",
       "      <td>Agilent QTOF</td>\n",
       "      <td>GC</td>\n",
       "      <td>positive mode</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-raw-spectral-data-file-R2</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>GRP1_SBJ01_run-in_SMP-blood-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-Extract-R1</td>\n",
       "      <td>polar fraction</td>\n",
       "      <td>assay0 - derivatization</td>\n",
       "      <td>bis(trimethylsilyl)acetamide</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-LE-R1</td>\n",
       "      <td>assay0 - mass spectrometry</td>\n",
       "      <td>Agilent QTOF</td>\n",
       "      <td>GC</td>\n",
       "      <td>positive mode</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S38-raw-spectral-data-file-R1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>...</th>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "      <td>...</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>475</th>\n",
       "      <td>GRP1_SBJ10_screen_SMP-liver-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-Extract-R2</td>\n",
       "      <td>lipids</td>\n",
       "      <td>assay0 - derivatization</td>\n",
       "      <td>bis(trimethylsilyl)acetamide</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-LE-R2</td>\n",
       "      <td>assay0 - mass spectrometry</td>\n",
       "      <td>Agilent QTOF</td>\n",
       "      <td>GC</td>\n",
       "      <td>negative mode</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-raw-spectral-data-file-R6</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>476</th>\n",
       "      <td>GRP1_SBJ10_screen_SMP-liver-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-Extract-R2</td>\n",
       "      <td>lipids</td>\n",
       "      <td>assay0 - derivatization</td>\n",
       "      <td>bis(trimethylsilyl)acetamide</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-LE-R2</td>\n",
       "      <td>assay0 - mass spectrometry</td>\n",
       "      <td>Agilent QTOF</td>\n",
       "      <td>GC</td>\n",
       "      <td>negative mode</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-raw-spectral-data-file-R5</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>477</th>\n",
       "      <td>GRP1_SBJ10_screen_SMP-liver-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-Extract-R1</td>\n",
       "      <td>polar fraction</td>\n",
       "      <td>assay0 - derivatization</td>\n",
       "      <td>bis(trimethylsilyl)acetamide</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-LE-R1</td>\n",
       "      <td>assay0 - mass spectrometry</td>\n",
       "      <td>Agilent QTOF</td>\n",
       "      <td>GC</td>\n",
       "      <td>negative mode</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-raw-spectral-data-file-R4</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>478</th>\n",
       "      <td>GRP1_SBJ10_screen_SMP-liver-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-Extract-R1</td>\n",
       "      <td>polar fraction</td>\n",
       "      <td>assay0 - derivatization</td>\n",
       "      <td>bis(trimethylsilyl)acetamide</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-LE-R1</td>\n",
       "      <td>assay0 - mass spectrometry</td>\n",
       "      <td>Agilent QTOF</td>\n",
       "      <td>GC</td>\n",
       "      <td>positive mode</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-raw-spectral-data-file-R2</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>479</th>\n",
       "      <td>GRP1_SBJ10_screen_SMP-liver-1</td>\n",
       "      <td>NO</td>\n",
       "      <td>assay0 - extraction</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-Extract-R1</td>\n",
       "      <td>polar fraction</td>\n",
       "      <td>assay0 - derivatization</td>\n",
       "      <td>bis(trimethylsilyl)acetamide</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-LE-R1</td>\n",
       "      <td>assay0 - mass spectrometry</td>\n",
       "      <td>Agilent QTOF</td>\n",
       "      <td>GC</td>\n",
       "      <td>negative mode</td>\n",
       "      <td>Unknown</td>\n",
       "      <td>AT0-S17-raw-spectral-data-file-R3</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "<p>480 rows × 16 columns</p>\n",
       "</div>"
      ],
      "text/plain": [
       "                       Sample Name Comment[study step with treatment]  \\\n",
       "0    GRP1_SBJ01_run-in_SMP-blood-1                                 NO   \n",
       "1    GRP1_SBJ01_run-in_SMP-blood-1                                 NO   \n",
       "2    GRP1_SBJ01_run-in_SMP-blood-1                                 NO   \n",
       "3    GRP1_SBJ01_run-in_SMP-blood-1                                 NO   \n",
       "4    GRP1_SBJ01_run-in_SMP-blood-1                                 NO   \n",
       "..                             ...                                ...   \n",
       "475  GRP1_SBJ10_screen_SMP-liver-1                                 NO   \n",
       "476  GRP1_SBJ10_screen_SMP-liver-1                                 NO   \n",
       "477  GRP1_SBJ10_screen_SMP-liver-1                                 NO   \n",
       "478  GRP1_SBJ10_screen_SMP-liver-1                                 NO   \n",
       "479  GRP1_SBJ10_screen_SMP-liver-1                                 NO   \n",
       "\n",
       "            Protocol REF Performer        Extract Name  \\\n",
       "0    assay0 - extraction   Unknown  AT0-S38-Extract-R2   \n",
       "1    assay0 - extraction   Unknown  AT0-S38-Extract-R1   \n",
       "2    assay0 - extraction   Unknown  AT0-S38-Extract-R1   \n",
       "3    assay0 - extraction   Unknown  AT0-S38-Extract-R1   \n",
       "4    assay0 - extraction   Unknown  AT0-S38-Extract-R1   \n",
       "..                   ...       ...                 ...   \n",
       "475  assay0 - extraction   Unknown  AT0-S17-Extract-R2   \n",
       "476  assay0 - extraction   Unknown  AT0-S17-Extract-R2   \n",
       "477  assay0 - extraction   Unknown  AT0-S17-Extract-R1   \n",
       "478  assay0 - extraction   Unknown  AT0-S17-Extract-R1   \n",
       "479  assay0 - extraction   Unknown  AT0-S17-Extract-R1   \n",
       "\n",
       "    Characteristics[extract type]           Protocol REF.1  \\\n",
       "0                          lipids  assay0 - derivatization   \n",
       "1                  polar fraction  assay0 - derivatization   \n",
       "2                  polar fraction  assay0 - derivatization   \n",
       "3                  polar fraction  assay0 - derivatization   \n",
       "4                  polar fraction  assay0 - derivatization   \n",
       "..                            ...                      ...   \n",
       "475                        lipids  assay0 - derivatization   \n",
       "476                        lipids  assay0 - derivatization   \n",
       "477                polar fraction  assay0 - derivatization   \n",
       "478                polar fraction  assay0 - derivatization   \n",
       "479                polar fraction  assay0 - derivatization   \n",
       "\n",
       "    Parameter Value[derivatization] Performer.1 Labeled Extract Name  \\\n",
       "0      bis(trimethylsilyl)acetamide     Unknown        AT0-S38-LE-R2   \n",
       "1      bis(trimethylsilyl)acetamide     Unknown        AT0-S38-LE-R1   \n",
       "2      bis(trimethylsilyl)acetamide     Unknown        AT0-S38-LE-R1   \n",
       "3      bis(trimethylsilyl)acetamide     Unknown        AT0-S38-LE-R1   \n",
       "4      bis(trimethylsilyl)acetamide     Unknown        AT0-S38-LE-R1   \n",
       "..                              ...         ...                  ...   \n",
       "475    bis(trimethylsilyl)acetamide     Unknown        AT0-S17-LE-R2   \n",
       "476    bis(trimethylsilyl)acetamide     Unknown        AT0-S17-LE-R2   \n",
       "477    bis(trimethylsilyl)acetamide     Unknown        AT0-S17-LE-R1   \n",
       "478    bis(trimethylsilyl)acetamide     Unknown        AT0-S17-LE-R1   \n",
       "479    bis(trimethylsilyl)acetamide     Unknown        AT0-S17-LE-R1   \n",
       "\n",
       "                 Protocol REF.2 Parameter Value[instrument]  \\\n",
       "0    assay0 - mass spectrometry                Agilent QTOF   \n",
       "1    assay0 - mass spectrometry                Agilent QTOF   \n",
       "2    assay0 - mass spectrometry                Agilent QTOF   \n",
       "3    assay0 - mass spectrometry                Agilent QTOF   \n",
       "4    assay0 - mass spectrometry                Agilent QTOF   \n",
       "..                          ...                         ...   \n",
       "475  assay0 - mass spectrometry                Agilent QTOF   \n",
       "476  assay0 - mass spectrometry                Agilent QTOF   \n",
       "477  assay0 - mass spectrometry                Agilent QTOF   \n",
       "478  assay0 - mass spectrometry                Agilent QTOF   \n",
       "479  assay0 - mass spectrometry                Agilent QTOF   \n",
       "\n",
       "    Parameter Value[injection_mode] Parameter Value[acquisition_mode]  \\\n",
       "0                                GC                     negative mode   \n",
       "1                                GC                     negative mode   \n",
       "2                                GC                     negative mode   \n",
       "3                                GC                     positive mode   \n",
       "4                                GC                     positive mode   \n",
       "..                              ...                               ...   \n",
       "475                              GC                     negative mode   \n",
       "476                              GC                     negative mode   \n",
       "477                              GC                     negative mode   \n",
       "478                              GC                     positive mode   \n",
       "479                              GC                     negative mode   \n",
       "\n",
       "    Performer.2             Raw Spectral Data File  \n",
       "0       Unknown  AT0-S38-raw-spectral-data-file-R6  \n",
       "1       Unknown  AT0-S38-raw-spectral-data-file-R4  \n",
       "2       Unknown  AT0-S38-raw-spectral-data-file-R3  \n",
       "3       Unknown  AT0-S38-raw-spectral-data-file-R2  \n",
       "4       Unknown  AT0-S38-raw-spectral-data-file-R1  \n",
       "..          ...                                ...  \n",
       "475     Unknown  AT0-S17-raw-spectral-data-file-R6  \n",
       "476     Unknown  AT0-S17-raw-spectral-data-file-R5  \n",
       "477     Unknown  AT0-S17-raw-spectral-data-file-R4  \n",
       "478     Unknown  AT0-S17-raw-spectral-data-file-R2  \n",
       "479     Unknown  AT0-S17-raw-spectral-data-file-R3  \n",
       "\n",
       "[480 rows x 16 columns]"
      ]
     },
     "execution_count": 28,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "isa_tables['a_AT0_metabolite-profiling_mass-spectrometry.txt']"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 29,
   "metadata": {},
   "outputs": [],
   "source": [
    "final_dir = os.path.abspath(os.path.join('notebook-output', 'sd-test'))"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### 7. Serialization as ISA-JSON and ISA-Tab"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "isa_j = json.dumps(isa_investigation, cls=ISAJSONEncoder, sort_keys=True, indent=4, separators=(',', ': '))\n",
    "open(os.path.join(final_dir,\"isa_as_json_from_dumps2.json\"),\"w\").write(isa_j) # this call write the string 'isa_j' to the file called 'isa_as_json_from_dumps.json'"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "isatab.dump(isa_obj=isa_investigation, output_path=final_dir)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### 8. Performing syntactic validation by invoking ISA Validator"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "with open(os.path.join(final_dir,'i_investigation.txt')) as isa:\n",
    "    validation_report=isatab.validate(isa)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": [
    "validation_report[\"errors\"]"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Conclusion:\n",
    "\n",
    "With this notebook, we have shown how to use study design information to generate a populated instance of ISA Study object and write it to file.\n",
    "\n"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## About this notebook\n",
    "\n",
    "- authors: philippe.rocca-serra@oerc.ox.ac.uk, massimiliano.izzo@oerc.ox.ac.uk\n",
    "- license: CC-BY 4.0\n",
    "- support: isatools@googlegroups.com\n",
    "- issue tracker: https://github.com/ISA-tools/isa-api/issues"
   ]
  }
 ],
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