Osnat Hakimi An ontology developed to facilitate information curation in the area of medical devices, experimental scaffolds and biomaterials. The ontology was designed to complement existing medical vocabularies, with emphasis on material procesing, structures and features associated with biomaterials and experimental scaffolds. Devices, Experimental scaffolds and Biomaterials Ontology (DEB) funcionalized functionalised nanoscale nanosized not treated untreated true true The production of fat, either fatty degeneration or fatty infiltration; also applied to the normal deposition of fat or to the conversion of carbohydrate or protein to fat. (Source: NCIT) http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20906 true Adsorption can be defined as the accumulation of a substance or material at an interface between the solid surface and the bathing solution. From: Encyclopedia of Soils in the Environment, 2005 An unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical device or biomaterial Adverse event Aligned mixture of two or more metals or of one or more metals with certain metalloids that are mutually soluble in the molten condition; distinguished as binary, ternary, quaternary, etc., depending on the number of metals in the mixture. [CRISP] http://purl.bioontology.org/ontology/CSP/1852-6667 http://purl.obolibrary.org/obo/CHEBI_142648 The property of being anisotropic, having a different value when measured in different directions. ncit:C17442 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17442 A heat treatment that alters the microstructure of a material causing changes in its properties such as strength and hardness http://purl.obolibrary.org/obo/CHMO_0001465 true true Characteristics related to the three dimensional organization, orientation and assembly of a manufactured object or its components. http://purl.bioontology.org/ontology/SNOMEDCT/257281002 A nerve guidance conduit Conduit A cellular or biological process that the manufactured object is designed to cause or support, or is measured to affect ncit:C17828 Biological Process PR:000000034 protein true Ceramics with biological functionality. true true Bioabsorbable Biodegradation Bioresorption The production of complex biologic products from raw materials such as living cells, matrices, biomaterials, and molecules. http://purl.jp/bio/4/id/201606009447904933 true Biofunctionalisation (or biofunctionalization) is the modification of a material to have biological function and/or stimulus, whether permanent or temporary while at the same time being biologically compatible. (wikipedia) Biofunctionalisation Substance, often a peptide or protein included in a manufactured object in order to impart a biological activity STY: T123 Biologically Active Substance A non-drug raw material or substance suitable for inclusion in systems which augment or replace the function of bodily tissues or organs bcteo Biomaterial Biomaterials Classification or nature of biomaterials Biomaterial Type true Occurring in or characterized by two stages or phases. http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25435 A mixture of different substances. true The action of mixing or combining substances such as polymers together. The action of joining things securely by means of adhesive, heat, or pressure or by chemical bonds. There are three primary types of bonding: ionic, covalent, and metallic. (Source: https://depts.washington.edu/matseed/ces_guide/bonding.htm#Metallic) adhesively bonded bonded true In textiles, machine or hand method of interlacing three or more yarns or bias-cut cloth strips in such a way that they cross one another and are laid together in diagonal formation, forming a narrow strip of flat or tubular fabric. bcteo:0000123 http://purl.obolibrary.org/obo/ID_0000123 CPC Casting is a manufacturing process in which a liquid material is usually poured into a mold, which contains a hollow cavity of the desired shape, and then allowed to solidify. The solidified part is also known as a casting, which is ejected or broken out of the mold to complete the process. (Wikipedia) Cell Attachment Microencapsulated Cells Refers to the ability of cells or exogenously administered cells to locate and enter an environmental niche. From: Liesveld, JL, Sharma, N, Aljitawi, OS. Stem cell homing: From physiology to therapeutics. Stem Cells. 2020; 38: 1241– 1253. Cell attachment Cell Differentiation Differentiation cell infiltration Cell Spreading Inorganic, nonmetallic solid prepared by the action of heat and subsequent cooling. [BCTEO] http://purl.bioontology.org/ontology/SNOMEDCT/261253002 A representation of a substance using symbols for its constituent elements. ncit:C48808 Chemotactic activity Chondrocyte Differentiation chronic inflammatory changes Coacervation is a chemical method for producing polymer droplets in suspension based on the separation of two liquid phases into one concentrated colloidal phase, being the coacervate, and another highly dilute colloidal phase. From: Piacentini E. (2016) Coacervation. In: Drioli E., Giorno L. (eds) Encyclopedia of Membranes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44324-8_2019 true The application of a thin cover to a material. [CHMO] http://purl.allotrope.org/ontologies/process#AFP_0001986 (CAP) treatment CAP treatment CHEBI:3815 chebi_ontology Materials made from two or more constituent materials with significantly different physical or chemical properties, that when combined, produce a material with characteristics different from the individual components. The individual components remain separate and distinct within the finished structure. [BCTEO] http://purl.obolibrary.org/obo/ID_0000154 true true Corrosion true The use of cross-links to promote a change in polymers' physical properties. The detection and quantification of the amount of amorphous material within a highly crystalline substance. ncit:C133974 true true true The physical, chemical and/or enzymatic processing of tissue samples to remove cells and leave behind the extracellular matrix or natural scaffold made up of collagen and other fibers and proteins. [NCIT] http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112947 Tissue Decellularization dECM true Degradation A process or characteristic related to the long term integrity of a manufactured object or its component. Degradation Features Demineralized allograft bone with osteoinductive activity. Demineralized bone matrices are prepared by acid extraction of allograft bone, resulting in loss of most of the mineralized component but retention of collagen and noncollagenous proteins, including growth factors. The efficacy of a demineralized bone matrix (DBM) as a bone-graft substitute or extender may be related to the total amount of bone morphogenetic protein (BMP) present, and the ratios of the different BMPs present. BMPs belong to the transforming growth factor (TGF) superfamily of proteins. http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61085 Dendritic ELPs OPB:00546 http://purl.obolibrary.org/obo/ID_0000009 DrugRelease Oedema Biological effect associated with manufactured object in a specific test system (cells, tissue or organism) Effect on Biological System true A process used to created very fine (μm or nm scale) fibres from a liquid. A high voltage is applied to a droplet of the liquid sample which is drawn out into fibres and cooled in air. http://purl.obolibrary.org/obo/CHMO_0001620 The emulsion solvent evaporation technique is a method for preparing nanoparticles and nanocapsules that are particularly adapted for applications requiring materials with high purity and low toxicity, such as for biomedicine or electronics. Definition from: Staff et al 2013. Recent Advances in the Emulsion Solvent Evaporation Technique for the Preparation of Nanoparticles and Nanocapsules true A physical object, named by the author of an experimental study, designed and created for in vitro and in vivo evaluation in conjunction with cells or living tissues Experimental Scaffold Scaffold scaffolds true true Fibers Fibre Fibres true true Foreign body freeze-dried freeze-drying true Functionalization can be the decoration of the scaffold surface with bioactive cues interacting with cells and the ECM to trigger tissue-specific phenotypes. From: Bone Substitute Biomaterials, 2014 true grooved substrate A coccidiostat used in veterinary medicine. Potent type-I collagen inhibitor CHEBI:28304 chebi_ontology Histological evaluation histomorphometric examination true A gel which is primarily composed of a network of polymer chains that are hydrophilic, sometimes found as a colloidal gel in which water is the dispersion medium. http://purl.bioontology.org/ontology/SNOMEDCT/303529009 true true HA Immunohistochemical examination Immunologic responses true ImplantRejection Rejection of The Implant true Impregnating Impregnation in-vitro in-vivo Inflammation inflammatory response IPOM true true true true Has a pore size of at least 50nm A physical object created by hand or machine STY: T073 Manufactured Object A part, region or component referred to as a distinct unit, such as surface, layer etc. Manufactured Object Component Characteristics inherent or given during processing to a manufactured object or its component Manufactured Object Features A planned process which results in physical changes in a specified input material. CHMO:0001267 OBI:0000094 Material Processing Matrices bcteo:0000173 http://purl.obolibrary.org/obo/ID_0000173 BCTEO:0000174 http://purl.obolibrary.org/obo/ID_0000174 MechanicalProperties Intended use, function or outcome of the manufactured object Medical Application A device with direct or indirect therapeutic purpose sty Medical Device Melt blending is a simple method for dispersing nanoparticles in a polymer matrix. From: Composites Science and Technology, 2012 true Has a pore size between 2-50 nm true true true true Has a pore size of up to 2 nm true true PATO:0001681 quality The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds http://purl.bioontology.org/ontology/MESH/D015394 A technique developed in the mid-70s of the last century to measure the elastic modulus, hardness, and fracture toughness of solid materials. From: Membrane Characterization, 2017 Instrumented indentation testing nano-indentation Biopolymers formulated and associated with nano-sized fillers, bringing a large range of improved properties (stiffness, permeability, crystallinity, thermal stability). true NPs Nanoscale topography NeoCollagenesis Neovasculogenesis true Non-degradable Nondegradable A technique used to extract topographical data from a surface. This can be done using a physical probe or by using light. true Osteoconductivity Osteoconduction true Osteodifferentiation true osteoinductivity chebi_ontology CHEBI:53200 Polycaprolactone poly(ethylene-glycol) Polyethyleneglycol poly(ethyleneglycol) Poly D,L lactic co glycolic acid Poly(glycolide:lactide) Polylactide-co-glycolide polylactic-co-glycolic acid Poly-L-lactic-acid Poly-L-lactide http://purl.bioontology.org/ontology/SNOMEDCT/6043006 polystyrene-block-poly(4-vinylpyridine) true true The photoinduced formation of a covalent bond between two macromolecules or between two different parts of one macromolecule. (https://en.wiktionary.org/wiki/photocrosslinking) Physical Property Pick up impression technique PACVD true PDGF PRP platelet-rich plasma true CHEBI:61607 PPDO poly(citric acid) PGS Poly L phenylalanine pPhe PTMC PHA PDO PDS PDX Polidioxanone Polydioxanon p-dioxanone poly(dioxanone) poly-dioxanone PDA PEU Dacron Mersilene PEI PG910 Dexon PGA PLA Poly L lactide Poly lactic acid poly(d,l-lactic acid) Poly L lysine pLys true Polymers polymeric true PTFE Teflon PVDF polyvinylidene difluoride true Porosity true true true The use of a quartz crystal microbalance for measuring weights and forces in the micro- to nanogram range. It is used to study the chemical and mechanical properties of thin layers, such as polymer coatings and lipid membranes; and interactions between molecues. (from: MESH) http://purl.bioontology.org/ontology/MESH/D058525 http://purl.obolibrary.org/obo/CHMO_0001077 Quartz crystal microbalance Radial compression strength Rapid prototyping is a group of techniques used to quickly fabricate a scale model of a physical part or assembly using three-dimensional computer aided design (CAD) data (Wikipedia). rhBMP rhPDGF true re-innervation A laboratory or clinical technique used to evaluate a biomaterial (or implant/device) and their effect. true true true SEM self-assembling self-expanding true semi-permeable The external form, contours, or outline of a manufactured object or a component CHEBI:26672 http://purl.obolibrary.org/obo/CHEBI_26672 true small-caliber The process of the settling of (nm sized) particles from a colloidal suspension onto a pre-existing surface, resulting in ceramic materials. The desired solid particles (e.g. metal alkoxides) are suspended in a liquid, forming the 'sol', which is deposited on a substrate by spinning, dipping or coating, or transferred to a mould. The particles in the sol are polymerised by partial evaporation of the solvent, or addition of an initiator, forming the 'gel', which is then heated at high temperature to give the final solid product. http://purl.obolibrary.org/obo/CHMO_0001313 sol–gel method true A method of producing a dry powder from a liquid or slurry by rapidly drying with a hot gas. This is the preferred method of drying of many thermally-sensitive materials such as foods and pharmaceuticals (wikipedia). spray-drying The structure, form or texture associated with a manufactured object or its components. Structure The set-up of the study (in vitro, in vivo, etc) true Implant Mechanical strength true Titania Titanium dioxide Titanium(IV) oxide TissueAugmentation Ti TiAlN [Ti(C,N,O)] true Transparancy tubes collagen (Type I) Vascularization Vascularisation water-in-oil-in-waterdouble-emulsion true true true true Three dimensional printing Polyhydroxyethylmethacrylate pHEMA Poly(HPMA) pHPMA PNAGA PNIPA PNIPAM Ethylene-vinyl acetate PEVA PGACL PVA Poly vinyl alcohol