An ontology developed to facilitate information curation in the area of medical devices, experimental scaffolds and biomaterials. The ontology was designed to complement existing medical vocabularies, with emphasis on material procesing, structures and features associated with biomaterials and experimental scaffolds.
Devices, Experimental scaffolds and Biomaterials Ontology (DEB)
The production of fat, either fatty degeneration or fatty infiltration; also applied to the normal deposition of fat or to the conversion of carbohydrate or protein to fat. (Source: NCIT)
Adsorption can be defined as the accumulation of a substance or material at an interface between the solid surface and the bathing solution. From: Encyclopedia of Soils in the Environment, 2005
An unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical device or biomaterial
mixture of two or more metals or of one or more metals with certain metalloids that are mutually soluble in the molten condition; distinguished as binary, ternary, quaternary, etc., depending on the number of metals in the mixture. [CRISP]
The property of being anisotropic, having a different value when measured in different directions.
A heat treatment that alters the microstructure of a material causing changes in its properties such as strength and hardness
Characteristics related to the three dimensional organization, orientation and assembly of a manufactured object or its components.
A cellular or biological process that the manufactured object is designed to cause or support, or is measured to affect
The production of complex biologic products from raw materials such as living cells, matrices, biomaterials, and molecules.
Biofunctionalisation (or biofunctionalization) is the modification of a material to have biological function and/or stimulus, whether permanent or temporary while at the same time being biologically compatible. (wikipedia)
Substance, often a peptide or protein included in a manufactured object in order to impart a biological activity
A non-drug raw material or substance suitable for inclusion in systems which augment or replace the function of bodily tissues or organs
Classification or nature of biomaterials
Occurring in or characterized by two stages or phases.
The action of mixing or combining substances such as polymers together.
The action of joining things securely by means of adhesive, heat, or pressure or by chemical bonds. There are three primary types of bonding: ionic, covalent, and metallic. (Source: https://depts.washington.edu/matseed/ces_guide/bonding.htm#Metallic)
In textiles, machine or hand method of interlacing three or more yarns or bias-cut cloth strips in such a way that they cross one another and are laid together in diagonal formation, forming a narrow strip of flat or tubular fabric.
Casting is a manufacturing process in which a liquid material is usually poured into a mold, which contains a hollow cavity of the desired shape, and then allowed to solidify. The solidified part is also known as a casting, which is ejected or broken out of the mold to complete the process. (Wikipedia)
Refers to the ability of cells or exogenously administered cells to locate and enter an environmental niche. From: Liesveld, JL, Sharma, N, Aljitawi, OS. Stem cell homing: From physiology to therapeutics. Stem Cells. 2020; 38: 1241– 1253.
Inorganic, nonmetallic solid prepared by the action of heat and subsequent cooling. [BCTEO]
A representation of a substance using symbols for its constituent elements.
Coacervation is a chemical method for producing polymer droplets in suspension based on the separation of two liquid phases into one concentrated colloidal phase, being the coacervate, and another highly dilute colloidal phase. From: Piacentini E. (2016) Coacervation. In: Drioli E., Giorno L. (eds) Encyclopedia of Membranes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44324-8_2019
The application of a thin cover to a material. [CHMO]
Materials made from two or more constituent materials with significantly different physical or chemical properties, that when combined, produce a material with characteristics different from the individual components. The individual components remain separate and distinct within the finished structure. [BCTEO]
The use of cross-links to promote a change in polymers' physical properties.
The detection and quantification of the amount of amorphous material within a highly crystalline substance.
The physical, chemical and/or enzymatic processing of tissue samples to remove cells and leave behind the extracellular matrix or natural scaffold made up of collagen and other fibers and proteins. [NCIT]
A process or characteristic related to the long term integrity of a manufactured object or its component.
Demineralized allograft bone with osteoinductive activity. Demineralized bone matrices are prepared by acid extraction of allograft bone, resulting in loss of most of the mineralized component but retention of collagen and noncollagenous proteins, including growth factors. The efficacy of a demineralized bone matrix (DBM) as a bone-graft substitute or extender may be related to the total amount of bone morphogenetic protein (BMP) present, and the ratios of the different BMPs present. BMPs belong to the transforming growth factor (TGF) superfamily of proteins.
Biological effect associated with manufactured object in a specific test system (cells, tissue or organism)
A process used to created very fine (μm or nm scale) fibres from a liquid. A high voltage is applied to a droplet of the liquid sample which is drawn out into fibres and cooled in air.
The emulsion solvent evaporation technique is a method for preparing nanoparticles and nanocapsules that are particularly adapted for applications requiring materials with high purity and low toxicity, such as for biomedicine or electronics. Definition from: Staff et al 2013. Recent Advances in the Emulsion Solvent Evaporation Technique for the Preparation of Nanoparticles and Nanocapsules
A physical object, named by the author of an experimental study, designed and created for in vitro and in vivo evaluation in conjunction with cells or living tissues
Functionalization can be the decoration of the scaffold surface with bioactive cues interacting with cells and the ECM to trigger tissue-specific phenotypes. From: Bone Substitute Biomaterials, 2014
A coccidiostat used in veterinary medicine. Potent type-I collagen inhibitor
A gel which is primarily composed of a network of polymer chains that are hydrophilic, sometimes found as a colloidal gel in which water is the dispersion medium.
A physical object created by hand or machine
A part, region or component referred to as a distinct unit, such as surface, layer etc.
Characteristics inherent or given during processing to a manufactured object or its component
A planned process which results in physical changes in a specified input material.
Intended use, function or outcome of the manufactured object
A device with direct or indirect therapeutic purpose
Melt blending is a simple method for dispersing nanoparticles in a polymer matrix. From: Composites Science and Technology, 2012
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds
A technique developed in the mid-70s of the last century to measure the elastic modulus, hardness, and fracture toughness of solid materials. From: Membrane Characterization, 2017
Biopolymers formulated and associated with nano-sized fillers, bringing a large range of improved properties (stiffness, permeability, crystallinity, thermal stability).
A technique used to extract topographical data from a surface. This can be done using a physical probe or by using light.
The photoinduced formation of a covalent bond between two macromolecules or between two different parts of one macromolecule. (https://en.wiktionary.org/wiki/photocrosslinking)
The use of a quartz crystal microbalance for measuring weights and forces in the micro- to nanogram range. It is used to study the chemical and mechanical properties of thin layers, such as polymer coatings and lipid membranes; and interactions between molecues. (from: MESH)
Rapid prototyping is a group of techniques used to quickly fabricate a scale model of a physical part or assembly using three-dimensional computer aided design (CAD) data (Wikipedia).
A laboratory or clinical technique used to evaluate a biomaterial (or implant/device) and their effect.
The external form, contours, or outline of a manufactured object or a component
The process of the settling of (nm sized) particles from a colloidal suspension onto a pre-existing surface, resulting in ceramic materials. The desired solid particles (e.g. metal alkoxides) are suspended in a liquid, forming the 'sol', which is deposited on a substrate by spinning, dipping or coating, or transferred to a mould. The particles in the sol are polymerised by partial evaporation of the solvent, or addition of an initiator, forming the 'gel', which is then heated at high temperature to give the final solid product.
A method of producing a dry powder from a liquid or slurry by rapidly drying with a hot gas. This is the preferred method of drying of many thermally-sensitive materials such as foods and pharmaceuticals (wikipedia).
The structure, form or texture associated with a manufactured object or its components.
The set-up of the study (in vitro, in vivo, etc)