Osnat Hakimi
An ontology developed to facilitate information curation in the area of medical devices, experimental scaffolds and biomaterials. The ontology was designed to complement existing medical vocabularies, with emphasis on material procesing, structures and features associated with biomaterials and experimental scaffolds.
Devices, Experimental scaffolds and Biomaterials Ontology (DEB)
funcionalized
functionalised
nanoscale
nanosized
not treated
untreated
true
true
The production of fat, either fatty degeneration or fatty infiltration; also applied to the normal deposition of fat or to the conversion of carbohydrate or protein to fat.
(Source: NCIT)
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20906
true
Adsorption can be defined as the accumulation of a substance or material at an interface between the solid surface and the bathing solution.
From: Encyclopedia of Soils in the Environment, 2005
An unfavorable or unintended disease, sign, or symptom (including an abnormal laboratory finding) that is temporally associated with the use of a medical device or biomaterial
Adverse event
Aligned
mixture of two or more metals or of one or more metals with certain metalloids that are mutually soluble in the molten condition; distinguished as binary, ternary, quaternary, etc., depending on the number of metals in the mixture. [CRISP]
http://purl.bioontology.org/ontology/CSP/1852-6667
http://purl.obolibrary.org/obo/CHEBI_142648
The property of being anisotropic, having a different value when measured in different directions.
ncit:C17442
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17442
A heat treatment that alters the microstructure of a material causing changes in its properties such as strength and hardness
http://purl.obolibrary.org/obo/CHMO_0001465
true
true
Characteristics related to the three dimensional organization, orientation and assembly of a manufactured object or its components.
http://purl.bioontology.org/ontology/SNOMEDCT/257281002
A nerve guidance conduit
Conduit
A cellular or biological process that the manufactured object is designed to cause or support, or is measured to affect
ncit:C17828
Biological Process
PR:000000034
protein
true
Ceramics with biological functionality.
true
true
Bioabsorbable
Biodegradation
Bioresorption
The production of complex biologic products from raw materials such as living cells, matrices, biomaterials, and molecules.
http://purl.jp/bio/4/id/201606009447904933
true
Biofunctionalisation (or biofunctionalization) is the modification of a material to have biological function and/or stimulus, whether permanent or temporary while at the same time being biologically compatible.
(wikipedia)
Biofunctionalisation
Substance, often a peptide or protein included in a manufactured object in order to impart a biological activity
STY: T123
Biologically Active Substance
A non-drug raw material or substance suitable for inclusion in systems which augment or replace the function of bodily tissues or organs
bcteo
Biomaterial
Biomaterials
Classification or nature of biomaterials
Biomaterial Type
true
Occurring in or characterized by two stages or phases.
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25435
A mixture of different substances.
true
The action of mixing or combining substances such as polymers together.
The action of joining things securely by means of adhesive, heat, or pressure or by chemical bonds. There are three primary types of bonding: ionic, covalent, and metallic.
(Source: https://depts.washington.edu/matseed/ces_guide/bonding.htm#Metallic)
adhesively bonded
bonded
true
In textiles, machine or hand method of interlacing three or more yarns or bias-cut cloth strips in such a way that they cross one another and are laid together in diagonal formation, forming a narrow strip of flat or tubular fabric.
bcteo:0000123
http://purl.obolibrary.org/obo/ID_0000123
CPC
Casting is a manufacturing process in which a liquid material is usually poured into a mold, which contains a hollow cavity of the desired shape, and then allowed to solidify. The solidified part is also known as a casting, which is ejected or broken out of the mold to complete the process.
(Wikipedia)
Cell Attachment
Microencapsulated Cells
Refers to the ability of cells or exogenously administered cells to locate and enter an environmental niche.
From: Liesveld, JL, Sharma, N, Aljitawi, OS. Stem cell homing: From physiology to therapeutics. Stem Cells. 2020; 38: 1241– 1253.
Cell attachment
Cell Differentiation
Differentiation
cell infiltration
Cell Spreading
Inorganic, nonmetallic solid prepared by the action of heat and subsequent cooling. [BCTEO]
http://purl.bioontology.org/ontology/SNOMEDCT/261253002
A representation of a substance using symbols for its constituent elements.
ncit:C48808
Chemotactic activity
Chondrocyte Differentiation
chronic inflammatory changes
Coacervation is a chemical method for producing polymer droplets in suspension based on the separation of two liquid phases into one concentrated colloidal phase, being the coacervate, and another highly dilute colloidal phase.
From: Piacentini E. (2016) Coacervation. In: Drioli E., Giorno L. (eds) Encyclopedia of Membranes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44324-8_2019
true
The application of a thin cover to a material. [CHMO]
http://purl.allotrope.org/ontologies/process#AFP_0001986
(CAP) treatment
CAP treatment
CHEBI:3815
chebi_ontology
Materials made from two or more constituent materials with significantly different physical or chemical properties, that when combined, produce a material with characteristics different from the individual components. The individual components remain separate and distinct within the finished structure. [BCTEO]
http://purl.obolibrary.org/obo/ID_0000154
true
true
Corrosion
true
The use of cross-links to promote a change in polymers' physical properties.
The detection and quantification of the amount of amorphous material within a highly crystalline substance.
ncit:C133974
true
true
true
The physical, chemical and/or enzymatic processing of tissue samples to remove cells and leave behind the extracellular matrix or natural scaffold made up of collagen and other fibers and proteins. [NCIT]
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C112947
Tissue Decellularization
dECM
true
Degradation
A process or characteristic related to the long term integrity of a manufactured object or its component.
Degradation Features
Demineralized allograft bone with osteoinductive activity. Demineralized bone matrices are prepared by acid extraction of allograft bone, resulting in loss of most of the mineralized component but retention of collagen and noncollagenous proteins, including growth factors. The efficacy of a demineralized bone matrix (DBM) as a bone-graft substitute or extender may be related to the total amount of bone morphogenetic protein (BMP) present, and the ratios of the different BMPs present. BMPs belong to the transforming growth factor (TGF) superfamily of proteins.
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61085
Dendritic ELPs
OPB:00546
http://purl.obolibrary.org/obo/ID_0000009
DrugRelease
Oedema
Biological effect associated with manufactured object in a specific test system (cells, tissue or organism)
Effect on Biological System
true
A process used to created very fine (μm or nm scale) fibres from a liquid. A high voltage is applied to a droplet of the liquid sample which is drawn out into fibres and cooled in air.
http://purl.obolibrary.org/obo/CHMO_0001620
The emulsion solvent evaporation technique is a method for preparing nanoparticles and nanocapsules that are particularly adapted for applications requiring materials with high purity and low toxicity, such as for biomedicine or electronics.
Definition from: Staff et al 2013. Recent Advances in the Emulsion Solvent Evaporation Technique for the Preparation of Nanoparticles and Nanocapsules
true
A physical object, named by the author of an experimental study, designed and created for in vitro and in vivo evaluation in conjunction with cells or living tissues
Experimental Scaffold
Scaffold
scaffolds
true
true
Fibers
Fibre
Fibres
true
true
Foreign body
freeze-dried
freeze-drying
true
Functionalization can be the decoration of the scaffold surface with bioactive cues interacting with cells and the ECM to trigger tissue-specific phenotypes.
From: Bone Substitute Biomaterials, 2014
true
grooved
substrate
A coccidiostat used in veterinary medicine. Potent type-I collagen inhibitor
CHEBI:28304
chebi_ontology
Histological evaluation
histomorphometric examination
true
A gel which is primarily composed of a network of polymer chains that are hydrophilic, sometimes found as a colloidal gel in which water is the dispersion medium.
http://purl.bioontology.org/ontology/SNOMEDCT/303529009
true
true
HA
Immunohistochemical examination
Immunologic responses
true
ImplantRejection
Rejection of The Implant
true
Impregnating
Impregnation
in-vitro
in-vivo
Inflammation
inflammatory response
IPOM
true
true
true
true
Has a pore size of at least 50nm
A physical object created by hand or machine
STY: T073
Manufactured Object
A part, region or component referred to as a distinct unit, such as surface, layer etc.
Manufactured Object Component
Characteristics inherent or given during processing to a manufactured object or its component
Manufactured Object Features
A planned process which results in physical changes in a specified input material.
CHMO:0001267
OBI:0000094
Material Processing
Matrices
bcteo:0000173
http://purl.obolibrary.org/obo/ID_0000173
BCTEO:0000174
http://purl.obolibrary.org/obo/ID_0000174
MechanicalProperties
Intended use, function or outcome of the manufactured object
Medical Application
A device with direct or indirect therapeutic purpose
sty
Medical Device
Melt blending is a simple method for dispersing nanoparticles in a polymer matrix.
From: Composites Science and Technology, 2012
true
Has a pore size between 2-50 nm
true
true
true
true
Has a pore size of up to 2 nm
true
true
PATO:0001681
quality
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds
http://purl.bioontology.org/ontology/MESH/D015394
A technique developed in the mid-70s of the last century to measure the elastic modulus, hardness, and fracture toughness of solid materials.
From: Membrane Characterization, 2017
Instrumented indentation testing
nano-indentation
Biopolymers formulated and associated with nano-sized fillers, bringing a large range of improved properties (stiffness, permeability, crystallinity, thermal stability).
true
NPs
Nanoscale topography
NeoCollagenesis
Neovasculogenesis
true
Non-degradable
Nondegradable
A technique used to extract topographical data from a surface. This can be done using a physical probe or by using light.
true
Osteoconductivity
Osteoconduction
true
Osteodifferentiation
true
osteoinductivity
chebi_ontology
CHEBI:53200
Polycaprolactone
poly(ethylene-glycol)
Polyethyleneglycol
poly(ethyleneglycol)
Poly D,L lactic co glycolic acid
Poly(glycolide:lactide)
Polylactide-co-glycolide
polylactic-co-glycolic acid
Poly-L-lactic-acid
Poly-L-lactide
http://purl.bioontology.org/ontology/SNOMEDCT/6043006
polystyrene-block-poly(4-vinylpyridine)
true
true
The photoinduced formation of a covalent bond between two macromolecules or between two different parts of one macromolecule.
(https://en.wiktionary.org/wiki/photocrosslinking)
Physical Property
Pick up impression technique
PACVD
true
PDGF
PRP
platelet-rich plasma
true
CHEBI:61607
PPDO
poly(citric acid)
PGS
Poly L phenylalanine
pPhe
PTMC
PHA
PDO
PDS
PDX
Polidioxanone
Polydioxanon
p-dioxanone
poly(dioxanone)
poly-dioxanone
PDA
PEU
Dacron
Mersilene
PEI
PG910
Dexon
PGA
PLA
Poly L lactide
Poly lactic acid
poly(d,l-lactic acid)
Poly L lysine
pLys
true
Polymers
polymeric
true
PTFE
Teflon
PVDF
polyvinylidene difluoride
true
Porosity
true
true
true
The use of a quartz crystal microbalance for measuring weights and forces in the micro- to nanogram range. It is used to study the chemical and mechanical properties of thin layers, such as polymer coatings and lipid membranes; and interactions between molecues.
(from: MESH)
http://purl.bioontology.org/ontology/MESH/D058525
http://purl.obolibrary.org/obo/CHMO_0001077
Quartz crystal microbalance
Radial compression strength
Rapid prototyping is a group of techniques used to quickly fabricate a scale model of a physical part or assembly using three-dimensional computer aided design (CAD) data (Wikipedia).
rhBMP
rhPDGF
true
re-innervation
A laboratory or clinical technique used to evaluate a biomaterial (or implant/device) and their effect.
true
true
true
SEM
self-assembling
self-expanding
true
semi-permeable
The external form, contours, or outline of a manufactured object or a component
CHEBI:26672
http://purl.obolibrary.org/obo/CHEBI_26672
true
small-caliber
The process of the settling of (nm sized) particles from a colloidal suspension onto a pre-existing surface, resulting in ceramic materials. The desired solid particles (e.g. metal alkoxides) are suspended in a liquid, forming the 'sol', which is deposited on a substrate by spinning, dipping or coating, or transferred to a mould. The particles in the sol are polymerised by partial evaporation of the solvent, or addition of an initiator, forming the 'gel', which is then heated at high temperature to give the final solid product.
http://purl.obolibrary.org/obo/CHMO_0001313
sol–gel method
true
A method of producing a dry powder from a liquid or slurry by rapidly drying with a hot gas. This is the preferred method of drying of many thermally-sensitive materials such as foods and pharmaceuticals (wikipedia).
spray-drying
The structure, form or texture associated with a manufactured object or its components.
Structure
The set-up of the study (in vitro, in vivo, etc)
true
Implant
Mechanical strength
true
Titania
Titanium dioxide
Titanium(IV) oxide
TissueAugmentation
Ti
TiAlN
[Ti(C,N,O)]
true
Transparancy
tubes
collagen (Type I)
Vascularization
Vascularisation
water-in-oil-in-waterdouble-emulsion
true
true
true
true
Three dimensional printing
Polyhydroxyethylmethacrylate
pHEMA
Poly(HPMA)
pHPMA
PNAGA
PNIPA
PNIPAM
Ethylene-vinyl acetate
PEVA
PGACL
PVA
Poly vinyl alcohol