{
  "schema_version": "2.0",
  "artifact_kind": "randomized_trial_protocol_reporting_manifest",
  "draft_status": "BLOCKED_INCOMPLETE_REPORTING_CHECKLIST_NOT_A_PROTOCOL_OR_ETHICS_APPROVAL",
  "safety_notice": "This manifest tracks SPIRIT reporting-item coverage only. It does not design, approve, register, conduct, amend, or submit a trial protocol.",
  "data_classification": "aggregate",
  "authorized_purpose": null,
  "authorization_verified": false,
  "guidance": {
    "base": "SPIRIT 2025",
    "item_count": 34,
    "statement_and_explanation_checked": false,
    "applicable_extensions": [],
    "applicable_extensions_reviewed": false,
    "extension_conflicts_resolved_by_methodologist": false
  },
  "protocol_metadata": {
    "authorized_protocol_reference": null,
    "protocol_version": null,
    "registry_reference": null,
    "ethics_record_reference": null
  },
  "checklist_items": {
    "S01": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S02": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S03": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S04": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S05": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S06": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S07": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S08": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S09": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S10": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S11": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S12": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S13": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S14": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S15": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S16": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S17": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S18": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S19": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S20": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S21": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S22": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S23": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S24": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S25": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S26": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S27": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S28": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S29": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S30": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S31": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S32": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S33": {"status": "missing", "source_fact_ids": [], "official_item_locator": null},
    "S34": {"status": "missing", "source_fact_ids": [], "official_item_locator": null}
  },
  "not_applicable_rationales": {},
  "participant_timeline_source_fact_ids": [],
  "provenance_manifest": null,
  "review": {
    "investigator_sponsor_review": "pending",
    "methodologist_review": "pending",
    "statistical_review": "pending",
    "safety_review": "pending",
    "ethics_regulatory_review": "pending",
    "protocol_approved": false
  }
}