KTAO: Kidney Tissue Atlas Ontology
type: Ontology
Contributor: Becky Steck
Contributor: Chrysta Lienczewski
Contributor: Deborah Hoshizaki
Contributor: Evren Azeloglu
Contributor: George Oliver
Contributor: John F. Bertram
Contributor: John O'Toole
Contributor: Jonathan Himmelfarb
Contributor: Laura Mariani
Contributor: Matthias Kretzler
Contributor: Michael Todd Valerius
Contributor: Ravi Iyengar
Contributor: Sean Mooney
Contributor: The KPMP Consortium
Contributor: Ulysses Balis
creator: Edison Ong
creator: Ghida Arnous
creator: Jennifer Schaub
creator: Lia Papageorge
creator: Ling Wan
creator: Yingtong Liu
creator: Yongqun "Oliver" He
date: 2024-03-16
description: KTAO (Kidney Tissue Atlas Ontology) is a community-based biomedical ontology. Its development is supported by the NIH-NIDDK supported Kidney Precision Medicine Project (KPMP).
Format: OWL-DL
subject: KTAO: A biomedical ontology that represents kidney tissue atlas.
version info: Vision Release: 1.0.121

Class_Code
type: AnnotationProperty
range: string
type: DatatypeProperty
imported from: NDF-RT.owl
code: C130

Class_Description
type: AnnotationProperty
range: string
type: DatatypeProperty
imported from: NDF-RT.owl
code: C262717

Display_Name
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C264
imported from: NDF-RT.owl

FDA_UNII
type: AnnotationProperty
range: string
type: DatatypeProperty
imported from: NDF-RT.owl
code: C12847068852884

Level
type: AnnotationProperty
type: DatatypeProperty
range: Datatype
  one of: Ingredient
  one of: Ingredient Strength
  one of: Packaged Product
  one of: VA Class
  one of: VA Product
imported from: NDF-RT.owl
code: C98

MeSH_CUI
type: AnnotationProperty
range: string
type: DatatypeProperty
imported from: NDF-RT.owl
code: C176

MeSH_DUI
type: AnnotationProperty
range: string
type: DatatypeProperty
imported from: NDF-RT.owl
code: C134

MeSH_Definition
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C142
imported from: NDF-RT.owl

MeSH_Name
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C287
imported from: NDF-RT.owl

NUI
type: AnnotationProperty
range: string
type: DatatypeProperty
imported from: NDF-RT.owl
code: C10490107818172

Print_Name
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C114
imported from: NDF-RT.owl

Product_Component
type: AnnotationProperty
type: ObjectProperty
imported from: NDF-RT.owl
code: C28035649040869

RxNorm_CUI
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C818
imported from: NDF-RT.owl

RxNorm_Name
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C819
imported from: NDF-RT.owl

SNOMED_CID
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C28502475289736
imported from: NDF-RT.owl

Status
type: AnnotationProperty
type: DatatypeProperty
range: Datatype
  one of: Active
  one of: Inactive
imported from: NDF-RT.owl
code: C27489601424203

Strength
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C100
imported from: NDF-RT.owl

Synonym
type: AnnotationProperty
range: string
type: DatatypeProperty
imported from: NDF-RT.owl
code: C136

UMLS_CUI
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C140
imported from: NDF-RT.owl

Units
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C102
imported from: NDF-RT.owl

VANDF_Record
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C262721
imported from: NDF-RT.owl

VA_National_Formulary_Name
type: AnnotationProperty
range: string
type: DatatypeProperty
code: C68
imported from: NDF-RT.owl

VUID
type: AnnotationProperty
range: string
type: DatatypeProperty
imported from: NDF-RT.owl
code: C262777

code
type: AnnotationProperty
range: string
type: DatatypeProperty
imported from: NDF-RT.owl
code: AHC0
read only: true

BFO OWL specification label
type: AnnotationProperty
editor preferred label: BFO OWL specification label
textual definition: Relates an entity in the ontology to the name of the variable that is used to represent it in the code that generates the BFO OWL file from the lispy specification.
curator note: Really of interest to developers only
sub property of: label

BFO CLIF specification label
type: AnnotationProperty
editor preferred label: BFO CLIF specification label
textual definition: Relates an entity in the ontology to the term that is used to represent it in the the CLIF specification of BFO2
definition source: Person:Alan Ruttenberg
curator note: Really of interest to developers only
sub property of: label

editor preferred label
type: AnnotationProperty
editor preferred label: editor preferred label
editor preferred label: editor preferred term
editor preferred label: editor preferred term~editor preferred label
has curation status: IAO_0000122
textual definition: The concise, meaningful, and human-friendly name for a class or property preferred by the ontology developers. (US-English)
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: editor preferred term
label: editor preferred term~editor preferred label

example of usage
type: AnnotationProperty
editor preferred label: example
editor preferred label: example of usage
has curation status: IAO_0000122
textual definition: A phrase describing how a class name should be used. May also include other kinds of examples that facilitate immediate understanding of a class semantics, such as widely known prototypical subclasses or instances of the class. Although essential for high level terms, examples for low level terms (e.g., Affymetrix HU133 array) are not
textual definition: A phrase describing how a term should be used and/or a citation to a work which uses it. May also include other kinds of examples that facilitate immediate understanding, such as widely know prototypes or instances of a class, or cases where a relation is said to hold.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

has curation status
type: AnnotationProperty
editor preferred label: has curation status
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Bill Bug
definition editor: PERSON:Melanie Courtot
definition source: OBI_0000281

textual definition
type: AnnotationProperty
editor preferred label: definition
editor preferred label: textual definition
has curation status: IAO_0000122
textual definition: English language definitions of what NCI means by the concept. These are limited to 1024 characters. They may also include information about the definition's source and attribution in a form that can easily be interpreted by software.
textual definition: The official OBI definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
textual definition: The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
editor note: 2012-04-05: Barry Smith The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. Can you fix to something like: A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. Alan Ruttenberg Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. On the specifics of the proposed definition: We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
has_exact_synonym: DEFINITION
label: definition

editor note
type: AnnotationProperty
editor preferred label: editor note
has curation status: IAO_0000122
textual definition: An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obfoundry.org/obo/obi>
definition source: GROUP:OBI:<http://purl.obofoundry.org/obo/obi>
database_cross_reference: IAO:0000116
has_obo_namespace: uberon
id: editor_note
is metadata tag: 1
is metadata tag: true
shorthand: editor_note

definition editor
type: AnnotationProperty
editor preferred label: definition editor
editor preferred label: term editor
has curation status: IAO_0000122
textual definition: Name of editor entering the definition in the file. The definition editor is a point of contact for information regarding the term. The definition editor may be, but is not always, the author of the definition, which may have been worked upon by several people
textual definition: Name of editor entering the term in the file. The term editor is a point of contact for information regarding the term. The term editor may be, but is not always, the author of the definition, which may have been worked upon by several people
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See http://code.google.com/p/information-artifact-ontology/issues/detail?id=115.
editor note: 20110707, MC: label update to term editor and definition modified accordingly. See https://github.com/information-artifact-ontology/IAO/issues/115.
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
label: term editor

alternative term
type: AnnotationProperty
editor preferred label: alternative term
has curation status: IAO_0000125
textual definition: An alternative name for a class or property which means the same thing as the preferred name (semantically equivalent)
definition editor: PERSON:Daniel Schober
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

definition source
type: AnnotationProperty
editor preferred label: definition source
has curation status: IAO_0000122
textual definition: Formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
textual definition: formal citation, e.g. identifier in external database to indicate / attribute source(s) for the definition. Free text indicate / attribute source(s) for the definition. EXAMPLE: Author Name, URI, MeSH Term C04, PUBMED ID, Wiki uri on 31.01.2007
definition editor: PERSON:Daniel Schober
definition source: Discussion on obo-discuss mailing-list, see http://bit.ly/hgm99w
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

has obsolescence reason
type: AnnotationProperty
editor preferred label: has obsolescence reason
textual definition: Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification.
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Melanie Courtot

curator note
type: AnnotationProperty
editor preferred label: curator note
has curation status: IAO_0000122
textual definition: An administrative note of use for a curator but of no use for a user
definition editor: PERSON:Alan Ruttenberg
database_cross_reference: IAO:0000232
has_obo_namespace: uberon
id: curator_notes
is metadata tag: 1
shorthand: curator_notes
label: curator notes

term tracker item
type: AnnotationProperty
editor preferred label: term tracker item
example of usage: the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/
has curation status: IAO_0000125
textual definition: An IRI or similar locator for a request or discussion of an ontology term.
definition editor: Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
definition source: Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
database_cross_reference: IAO:0000233
has_obo_namespace: external
has_obo_namespace: uberon
id: term_tracker_item
is class level: true
is metadata tag: true
shorthand: term_tracker_item
comment: The 'tracker item' can associate a tracker with a specific ontology term.

ontology term requester
type: AnnotationProperty
editor preferred label: ontology term requester
has curation status: IAO_0000125
textual definition: The name of the person, project, or organization that motivated inclusion of an ontology term by requesting its addition.
definition editor: Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
definition source: Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
comment: The 'term requester' can credit the person, organization or project who request the ontology term.

imported from
type: AnnotationProperty
editor preferred label: imported from
has curation status: IAO_0000125
textual definition: For external terms/classes, the ontology from which the term was imported
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Melanie Courtot
definition source: GROUP:OBI:<http://purl.obolibrary.org/obo/obi>

expand expression to
type: AnnotationProperty
editor preferred label: expand expression to
example of usage: ObjectProperty: RO_0002104 Label: has plasma membrane part Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)"
textual definition: A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones
definition editor: Chris Mungall

expand assertion to
type: AnnotationProperty

OBO foundry unique label
type: AnnotationProperty
editor preferred label: OBO foundry unique label
has curation status: IAO_0000125
textual definition: An alternative name for a class or property which is unique across the OBO Foundry.
editor note: The intended usage of that property is as follow: OBO foundry unique labels are automatically generated based on regular expressions provided by each ontology, so that SO could specify unique label = 'sequence ' + [label], etc. , MA could specify 'mouse + [label]' etc. Upon importing terms, ontology developers can choose to use the 'OBO foundry unique label' for an imported term or not. The same applies to tools .
definition editor: PERSON:Alan Ruttenberg
definition editor: PERSON:Bjoern Peters
definition editor: PERSON:Chris Mungall
definition editor: PERSON:Melanie Courtot
definition source: GROUP:OBO Foundry <http://obofoundry.org/>

elucidation
type: AnnotationProperty
editor preferred label: elucidation
definition editor: person:Alan Ruttenberg
definition source: Person:Barry Smith
elucidation: Primitive terms in a highest-level ontology such as BFO are terms which are so basic to our understanding of reality that there is no way of defining them in a non-circular fashion. For these, therefore, we can provide only elucidations, supplemented by examples and by axioms

has associated axiom(nl)
type: AnnotationProperty
editor preferred label: has associated axiom(nl)
definition editor: Person:Alan Ruttenberg
definition source: Person:Alan Ruttenberg
elucidation: An axiom associated with a term expressed using natural language

has associated axiom(fol)
type: AnnotationProperty
editor preferred label: has associated axiom(fol)
definition editor: Person:Alan Ruttenberg
definition source: Person:Alan Ruttenberg
elucidation: An axiom expressed in first order logic using CLIF syntax

has ontology root term
type: AnnotationProperty
editor preferred label: has ontology root term
textual definition: Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root.
definition editor: Nicolas Matentzoglu
database_cross_reference: IAO:0000700
has_obo_namespace: external
has_obo_namespace: uberon
id: has_ontology_root_term
is class level: true
is metadata tag: true
shorthand: has_ontology_root_term
label: preferred_root

term replaced by
type: AnnotationProperty

term_mapping_to_UMLS
type: AnnotationProperty
term_mapping_to_UMLS: C3829466
term_mapping_to_NCIT: NCIT_C106180
sub property of: seeAlso

term_mapping_to_NCIT
type: AnnotationProperty
sub property of: seeAlso

Has_NICHD_Parent
type: AnnotationProperty
textual definition: A property created to allow the source NICHD to assign a parent to each concept with the intent of creating a hierarchy that includes only terms in which they are the contributing source.
code: A11
Semantic_Type: Conceptual Entity
Preferred_Name: Has_NICHD_Parent
has_exact_synonym: Has_NICHD_Parent

code
type: AnnotationProperty
read only: true
code: NHC0
Preferred_Name: code
has_exact_synonym: code

Semantic_Type
type: AnnotationProperty
textual definition: The semantic type describes the sort of thing or category to which a concept belongs in the context of the UMLS semantic network.
code: P106
Semantic_Type: Conceptual Entity
Display_Name: Semantic Type
Preferred_Name: Semantic_Type
DesignNote: In general, applying semantic types aids in allowing users (or computer programs) to draw conclusions about concepts by virtue of the categories to which they have been assigned. We use a set of semantic types developed for the UMLS Metathesaurus. There are currently 134 semantic types in the UMLS.
has_exact_synonym: Semantic_Type

Display_Name
type: AnnotationProperty
textual definition: Provides an alternative Preferred Name for use in some NCI systems.
code: P107
Semantic_Type: Conceptual Entity
Display_Name: Display Name
Preferred_Name: Display_Name
has_exact_synonym: Display Name
has_exact_synonym: Display_Name

Preferred_Name
type: AnnotationProperty
textual definition: The word or phrase that NCI uses by preference to refer to the concept.
code: P108
Semantic_Type: Conceptual Entity
Display_Name: Preferred Name
Preferred_Name: Preferred_Name
has_exact_synonym: Preferred Name
has_exact_synonym: Preferred Term
has_exact_synonym: Preferred_Name

UMLS_CUI
type: AnnotationProperty
textual definition: Concept Unique Identifiers, or CUIs, are concept numbers assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept.
code: P207
Semantic_Type: Conceptual Entity
Display_Name: UMLS CUI
Preferred_Name: UMLS_CUI
has_exact_synonym: UMLS_CUI

NCI_META_CUI
type: AnnotationProperty
textual definition: Contains a Concept Unique Identifier for those concepts that appear in NCI Metathesaurus but not in the NLM UMLS.
code: P208
Semantic_Type: Conceptual Entity
Display_Name: NCI Metathesaurus CUI
Preferred_Name: NCI_META_CUI
has_exact_synonym: NCI_META_CUI

Concept_Status
type: AnnotationProperty
textual definition: An NCI Thesaurus property used to indicate the standing of a concept in relation to currently accepted classifications and concepts. In NCI Thesaurus concept status subtype indicates concepts with unusual and problematic characteristics that should be evaluated by people and/or programs before those concept are used.
code: P310
Semantic_Type: Conceptual Entity
Display_Name: Concept Status
Preferred_Name: Concept_Status
has_exact_synonym: Concept_Status

Contributing_Source
type: AnnotationProperty
textual definition: This property is used to indicate when a non-EVS entity has contributed to, and has a stake in, a concept. This is used where such entities, within or outside NCI, have indicated the need to be able to track their own concepts. A single concept can have multiple instances of this property if multiple entities have such a defined stake.
code: P322
Semantic_Type: Conceptual Entity
Display_Name: Contributing Source
Preferred_Name: Contributing_Source
has_exact_synonym: Contributing_Source

ALT_DEFINITION
type: AnnotationProperty
textual definition: English language definitions of what a source other than NCI means by the concept. These are limited to 1024 characters. They include information about the definition's source in a form that can easily be interpreted by software.
code: P325
Semantic_Type: Conceptual Entity
Display_Name: [source] Definition
Preferred_Name: ALT_DEFINITION
has_exact_synonym: ALT_DEFINITION

Legacy_Concept_Name
type: AnnotationProperty
read only: true
textual definition: A retired unique concept identifier created and stored as Concept Name by legacy EVS software. Use of these values was long discouraged, but continued as late as 2009 when creation of new values ceased and Concept Name was retired. Legacy values are intended solely to help resolve and update earlier coding.
code: P366
Semantic_Type: Conceptual Entity
Preferred_Name: Legacy Concept Name
has_exact_synonym: Legacy Concept Name

NICHD_Hierarchy_Term
type: AnnotationProperty
code: P371
Semantic_Type: Conceptual Entity
Preferred_Name: NICHD_Hierarchy_Term
Contributing_Source: NICHD
has_exact_synonym: NICHD_Hierarchy_Term

DesignNote
type: AnnotationProperty
textual definition: Design notes are notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept.
code: P98
Semantic_Type: Conceptual Entity
Display_Name: DesignNote
Preferred_Name: DesignNote
has_exact_synonym: DesignNote

has_MedDRA_id
type: AnnotationProperty
label: has_meddra_id

ISA alternative term
type: AnnotationProperty
editor preferred label: ISA alternative term
has curation status: IAO_0000122
textual definition: An alternative term used by the ISA tools project (http://isa-tools.org).
editor note: Requested by Alejandra Gonzalez-Beltran https://sourceforge.net/tracker/?func=detail&aid=3603413&group_id=177891&atid=886178
definition editor: Person: Alejandra Gonzalez-Beltran
definition editor: Person: Philippe Rocca-Serra
definition source: ISA tools project (http://isa-tools.org)
sub property of: alternative term

NIAID GSCID-BRC alternative term
type: AnnotationProperty
editor preferred label: NIAID GSCID-BRC alternative term
has curation status: IAO_0000122
textual definition: An alternative term used by the National Institute of Allergy and Infectious Diseases (NIAID) Genomic Sequencing Centers for Infectious Diseases (GSCID) and Bioinformatics Resource Centers (BRC).
definition editor: PERSON: Chris Stoeckert, Jie Zheng
definition source: NIAID GSCID-BRC metadata working group
sub property of: alternative term

IEDB alternative term
type: AnnotationProperty
editor preferred label: IEDB alternative term
has curation status: IAO_0000122
textual definition: An alternative term used by the IEDB.
definition editor: PERSON:Randi Vita, Jason Greenbaum, Bjoern Peters
definition source: IEDB
sub property of: alternative term

symbol from nomenclature authority
type: AnnotationProperty
textual definition: the symbol assigned by the nomenclature authority
definition editor: Oliver He, Yue Liu

full name from nomenclature authority
type: AnnotationProperty
textual definition: the full name assigned by the nomenclature authority
definition editor: Oliver He, Yue Liu

NCBI GeneID
type: AnnotationProperty
textual definition: A GeneID in the NCBI Gene database
definition editor: Oliver He, Yue Liu

NCBI LocusTag
type: AnnotationProperty
textual definition: the NCBI LocusTag name of a gene
definition editor: Oliver He, Yue Liu

gene map location
type: AnnotationProperty
textual definition: the map location of a gene
definition editor: Oliver He, Yue Liu

modification date
type: AnnotationProperty
textual definition: a date of content modification
definition editor: Oliver He, Yue Liu

organism NCBITaxon ID
type: AnnotationProperty
textual definition: The NCBITaxon ontology ID of an organism.
definition editor: Oliver He, Yue Liu

chromosome ID of gene
type: AnnotationProperty
textual definition: A chromosome ID where a gene is located.
definition editor: Oliver He

type of gene
type: AnnotationProperty
textual definition: an annotation property that specifies the type of a gene
definition editor: Oliver He

nomenclature status
type: AnnotationProperty
textual definition: an annotation property that specifies a nomenclature status
definition editor: Oliver He

has GO association
type: AnnotationProperty
textual definition: an annotation property that shows the GO information associated with a specific gene.
definition editor: Yongqun He
comment: YH: use the convention: GO_ID (EC: xx; Qualifier: xx; PMID: xxxxx;) where GO_ID is a GO ID, EC is the Evidence Code, Qualifier is a specific association type, and PMID is a PubMed ID of a paper that supports the gene-GO association.
domain: OGG_0000000002

has PubMed association
type: AnnotationProperty
textual definition: An annotation property that represents a gene's association with PubMed publication(s).
definition editor: Yongqun He
comment: YH: use the format: PMID: pmid1, pmid2, ... where pmid1 and pmid2 are specfic PubMed IDs (PMIDs).

defined by construct
type: AnnotationProperty
example of usage: 'part disjoint with' 'defined by construct' """ PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX : <http://example.org/ CONSTRUCT { [ a owl:Restriction ; owl:onProperty :part_of ; owl:someValuesFrom ?a ; a owl:Restriction ; owl:onProperty :part_of ; owl:someValuesFrom ?b ] ] } WHERE { ?a :part_disjoint_with ?b . }
textual definition: Links an annotation property to a SPARQL CONSTRUCT query which is meant to provide semantics for a shortcut relation.
term tracker item: https://github.com/ontodev/robot/issues/963
Contributor: https://orcid.org/0000-0002-7356-1779
Contributor: https://orcid.org/0000-0002-8688-6599

term mapping to NCIT ID
type: AnnotationProperty
textual definition: A subproperty of seeAlso that represents a NCIT identifier mapped to the specified term
definition editor: Oliver He
sub property of: see also

term mapping to UMLS CUI
type: AnnotationProperty
textual definition: A subproperty of seeAlso that represents a UMLS CUI identifier mapped to the specified term
definition editor: Oliver He
sub property of: see also

NCIT code
type: AnnotationProperty
textual definition: An annotation property that refers to a code defined by NCIT

alternative term in Chinese
type: AnnotationProperty
sub property of: alternative term

temporal interpretation
type: AnnotationProperty
textual definition: An assertion that holds between an OWL Object Property and a temporal interpretation that elucidates how OWL Class Axioms that use this property are to be interpreted in a temporal context.
sub property of: logical macro assertion on an object property

never in taxon
type: AnnotationProperty
example of usage: tooth SubClassOf 'never in taxon' value 'Aves'
textual definition: S never_in_taxon T iff: S SubClassOf in_taxon only not T.
textual definition: x never in taxon T if and only if T is a class, and x does not instantiate the class expression "in taxon some T". Note that this is a shortcut relation, and should be used as a hasValue restriction in OWL.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/17921072
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20973947
expand assertion to: ?X DisjointWith RO_0002162 some ?Y
expand assertion to: Class: <http://www.w3.org/2002/07/owl#Nothing> EquivalentTo: ?X and (RO_0002162 some ?Y)
expand assertion to: Class: ?X DisjointWith: RO_0002162 some ?Y
defined by construct: PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#> PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX in_taxon: <http://purl.obolibrary.org/obo/RO_0002162> PREFIX never_in_taxon: <http://purl.obolibrary.org/obo/RO_0002161> CONSTRUCT { in_taxon: a owl:ObjectProperty . a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom ?taxon ] . ?x rdfs:subClassOf [ a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom [ a owl:Class ; owl:complementOf ?taxon ] ] . } WHERE { ?x never_in_taxon: ?taxon . }
database_cross_reference: RO:0002161
has_obo_namespace: uberon
id: never_in_taxon
is class level: true
is metadata tag: true
shorthand: never_in_taxon
label: never_in_taxon
sub property of: taxonomic class assertion

taxonomic class assertion
type: AnnotationProperty
textual definition: An assertion that holds between an ontology class and an organism taxon class, which is intepreted to yield some relationship between instances of the ontology class and the taxon.
sub property of: logical macro assertion on a class

dubious_for_taxon
type: AnnotationProperty
textual definition: S dubious_for_taxon T if it is probably the case that no instances of S can be found in any instance of T.
database_cross_reference: RO:0002174
has_obo_namespace: uberon
id: dubious_for_taxon
is class level: 1
is metadata tag: 1
shorthand: dubious_for_taxon
comment: this relation lacks a strong logical interpretation, but can be used in place of never_in_taxon where it is desirable to state that the definition of the class is too strict for the taxon under consideration, but placing a never_in_taxon link would result in a chain of inconsistencies that will take time to resolve. Example: metencephalon in teleost

present_in_taxon
type: AnnotationProperty
textual definition: S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S
textual definition: S present_in_taxon T if some instance of T has some S. This does not means that all instances of T have an S - it may only be certain life stages or sexes that have S.
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
defined by construct: PREFIX rdfs: <http://www.w3.org/2000/01/rdf-schema#> PREFIX owl: <http://www.w3.org/2002/07/owl#> PREFIX in_taxon: <http://purl.obolibrary.org/obo/RO_0002162> PREFIX present_in_taxon: <http://purl.obolibrary.org/obo/RO_0002175> CONSTRUCT { in_taxon: a owl:ObjectProperty . ?witness rdfs:label ?label . ?witness rdfs:subClassOf ?x . ?witness rdfs:subClassOf [ a owl:Restriction ; owl:onProperty in_taxon: ; owl:someValuesFrom ?taxon ] . } WHERE { ?x present_in_taxon: ?taxon . BIND(IRI(CONCAT( "http://purl.obolibrary.org/obo/RO_0002175#", MD5(STR(?x)), "-", MD5(STR(?taxon)) )) as ?witness) BIND(CONCAT(STR(?x), " in taxon ", STR(?taxon)) AS ?label) }
database_cross_reference: RO:0002175
has_exact_synonym: applicable for taxon
has_obo_namespace: uberon
id: present_in_taxon
is class level: 1
is class level: true
is metadata tag: 1
is metadata tag: true
shorthand: present_in_taxon
comment: The SPARQL expansion for this relation introduces new named classes into the ontology. For this reason it is likely that the expansion should only be performed during a QC pipeline; the expanded output should usually not be included in a published version of the ontology.
label: present in taxon

logical macro assertion
type: AnnotationProperty
textual definition: An assertion that involves at least one OWL object that is intended to be expanded into one or more logical axioms. The logical expansion can yield axioms expressed using any formal logical system, including, but not limited to OWL2-DL.

logical macro assertion on a class
type: AnnotationProperty
textual definition: A logical macro assertion whose domain is an IRI for a class
editor note: The domain for this class can be considered to be owl:Class, but we cannot assert this in OWL2-DL
sub property of: logical macro assertion

logical macro assertion on a property
type: AnnotationProperty
textual definition: A logical macro assertion whose domain is an IRI for a property
sub property of: logical macro assertion

logical macro assertion on an object property
type: AnnotationProperty
textual definition: Used to annotate object properties to describe a logical meta-property or characteristic of the object property.
sub property of: logical macro assertion on a property

logical macro assertion on an annotation property
type: AnnotationProperty
sub property of: logical macro assertion on a property

is direct form of
type: AnnotationProperty
textual definition: relation p is the direct form of relation q iff p is a subPropertyOf q, p does not have the Transitive characteristic, q does have the Transitive characteristic, and for all x, y: x q y -> exists z1, z2, ..., zn such that x p z1 ... z2n y
logical macro assertion on an annotation property: If we have the annotation P is-direct-form-of Q, and we have inverses P' and Q', then it follows that P' is-direct-form-of Q'
creator: Chris Mungall
sub property of: logical macro assertion on an object property

is a defining property chain axiom
type: AnnotationProperty
textual definition: If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL

is negative form of
type: AnnotationProperty
created by: https://orcid.org/0000-0002-6601-2165
creation date: 2018-03-14T00:03:24Z

external_definition
type: AnnotationProperty
textual definition: An alternate textual definition for a class taken unmodified from an external source. This definition may have been used to derive a generalized definition for the new class.
database_cross_reference: UBPROP:0000001
has_obo_namespace: uberon
id: external_definition
is metadata tag: 1
is metadata tag: true
shorthand: external_definition
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

axiom_lost_from_external_ontology
type: AnnotationProperty
textual definition: A textual description of an axiom loss in this ontology compared to an external ontology.
database_cross_reference: UBPROP:0000002
has_obo_namespace: uberon
id: axiom_lost_from_external_ontology
is metadata tag: 1
shorthand: axiom_lost_from_external_ontology
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

homology_notes
type: AnnotationProperty
textual definition: Notes on the homology status of this class.
database_cross_reference: UBPROP:0000003
has_obo_namespace: uberon
id: homology_notes
is metadata tag: 1
is metadata tag: true
shorthand: homology_notes
comment: This annotation property may be replaced with an annotation property from an external ontology such as IAO

has_relational_adjective
type: AnnotationProperty
curator note: Used to connect a class to an adjectival form of its label. For example, a class with label 'intestine' may have a relational adjective 'intestinal'.
database_cross_reference: UBPROP:0000007
has_obo_namespace: uberon
id: has_relational_adjective
is metadata tag: 1
shorthand: has_relational_adjective

taxon_notes
type: AnnotationProperty
textual definition: Notes on the how instances of this class vary across species.
database_cross_reference: UBPROP:0000008
has_obo_namespace: uberon
id: taxon_notes
is metadata tag: 1
shorthand: taxon_notes

structure_notes
type: AnnotationProperty
textual definition: Notes on the structure, composition or histology of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000010
has_obo_namespace: uberon
id: structure_notes
is metadata tag: 1
shorthand: structure_notes

development_notes
type: AnnotationProperty
textual definition: Notes on the ontogenic development of instances of this class.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000011
has_obo_namespace: uberon
id: development_notes
is metadata tag: 1
shorthand: development_notes

external_ontology_notes
type: AnnotationProperty
textual definition: Notes on how similar or equivalent classes are represented in other ontologies.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000012
has_obo_namespace: uberon
id: external_ontology_notes
is metadata tag: 1
shorthand: external_ontology_notes

terminology_notes
type: AnnotationProperty
textual definition: Notes on how lexical conventions regarding this class, in particular any issues that may arise due to homonyny or synonymy.
editor note: This annotation property may be replaced with an annotation property from an external ontology such as IAO
database_cross_reference: UBPROP:0000013
has_obo_namespace: uberon
id: terminology_notes
is metadata tag: 1
shorthand: terminology_notes

trade name
type: AnnotationProperty
textual definition: An annotation property that represents the trade name of a product.
definition editor: YH

vaccine proper name
type: AnnotationProperty
example of usage: The vaccine Prevnar (trade name) has a FDA-defined proper name: Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein). Reference: https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm180017.htm
textual definition: An annotation property that represents the proper name of a vaccine, which is defined in an official way such as one defined by FDA.
definition editor: Oliver He, Kallan Roan

manufacturer
type: AnnotationProperty
example of usage: The vaccine Prevnar has the manufacturer: Wyeth Pharmaceuticals Inc. Reference: https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm180017.htm
textual definition: An annotation property that represents the manufacturer of a product such as vaccine
definition editor: Oliver He, Kallan Roan

FDA vaccine indications
type: AnnotationProperty
example of usage: The vaccine Prevnar has the indications: - Immunization of infants 2, 4, 6 and 12-15 months of age to prevent invasive pneumococcal disease. - Immunization of infants and toddlers against otitis media caused by vaccine serotypes. Reference: https://www.fda.gov/biologicsbloodvaccines/vaccines/approvedproducts/ucm180017.htm
textual definition: An annotation property that represents the indications of a vaccine defined by the USA FDA.
definition editor: Oliver He, Kallan Roan

vaccine package insert PDF URL
type: AnnotationProperty
example of usage: Prevnar has the package insert PDF URL: https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM137038.pdf . Recorded on 11/26/2018.
textual definition: An annotation property that represents a URL of the package insert PDF document of a licensed vaccine
definition editor: Oliver He, Kallan Roan

vaccine STN
type: AnnotationProperty
textual definition: A number that is generated by FDA based on a request from an applicant of a product licensing.
definition editor: Oliver He, Kallan Roan
alternative term: vaccine submission’s tracking number
definition source: https://www.fda.gov/downloads/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/ProceduresSOPPs/UCM461225.pdf
vaccine STN: BLA 101094

excluded from QC check
type: AnnotationProperty
id: excluded_from_qc_check
is metadata tag: true

excluded subClassOf
type: AnnotationProperty
id: excluded_subClassOf
is metadata tag: true

has_rank
type: AnnotationProperty
textual definition: A metadata relation between a class and its taxonomic rank (eg species, family)
has_obo_namespace: ncbi_taxonomy

Contributor
type: AnnotationProperty
description: Examples of a Contributor include a person, an organisation, or a service. Typically, the name of a Contributor should be used to indicate the entity.
has_obo_namespace: uberon
id: dc-contributor
is metadata tag: 1
is metadata tag: true
shorthand: dc-contributor
comment: An entity responsible for making contributions to the content of the resource.
label: contributor

Creator
type: AnnotationProperty
description: Examples of a Creator include a person, an organisation, or a service. Typically, the name of a Creator should be used to indicate the entity.
id: dc-creator
shorthand: dc-creator
comment: An entity primarily responsible for making the content of the resource.
label: creator

Date
type: AnnotationProperty
description: Typically, Date will be associated with the creation or availability of the resource. Recommended best practice for encoding the date value is defined in a profile of ISO 8601 [W3CDTF] and follows the YYYY-MM-DD format.
comment: A date associated with an event in the life cycle of the resource.

Description
type: AnnotationProperty
description: Description may include but is not limited to: an abstract, table of contents, reference to a graphical representation of content or a free-text account of the content.
has_obo_namespace: uberon
id: dc-description
is metadata tag: true
shorthand: dc-description
comment: An account of the content of the resource.
label: description

Format
type: AnnotationProperty
description: Typically, Format may include the media-type or dimensions of the resource. Format may be used to determine the software, hardware or other equipment needed to display or operate the resource. Examples of dimensions include size and duration. Recommended best practice is to select a value from a controlled vocabulary (for example, the list of Internet Media Types [MIME] defining computer media formats).
comment: The physical or digital manifestation of the resource.

Source
type: AnnotationProperty
description: The present resource may be derived from the Source resource in whole or in part. Recommended best practice is to reference the resource by means of a string or number conforming to a formal identification system.
comment: A reference to a resource from which the present resource is derived.

Subject and Keywords
type: AnnotationProperty
description: Typically, a Subject will be expressed as keywords, key phrases or classification codes that describe a topic of the resource. Recommended best practice is to select a value from a controlled vocabulary or formal classification scheme.
comment: The topic of the content of the resource.

title
type: AnnotationProperty
has_obo_namespace: uberon
id: dc-title
is metadata tag: true
shorthand: dc-title

contributor
type: AnnotationProperty
has_obo_namespace: uberon
id: dc-contributor
is metadata tag: true
shorthand: dc-contributor

date
type: AnnotationProperty
has_obo_namespace: uberon
id: dcterms-date
is metadata tag: true
shorthand: dcterms-date

license
type: AnnotationProperty
definition editor: Mark Miller
date: 2018-05-11T13:47:29Z
has_obo_namespace: uberon
id: dcterms-license
is metadata tag: true
shorthand: dcterms-license

consider
type: AnnotationProperty

created by
type: AnnotationProperty

creation date
type: AnnotationProperty

has_alternative_id
type: AnnotationProperty

has_broad_synonym
type: AnnotationProperty
textual definition: An alternative label for a class or property which has a more general meaning than the preferred name/primary label.
definition editor: http://orcid.org/0000-0001-5208-3432
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/18
label: has broad synonym

database_cross_reference
type: AnnotationProperty

has_exact_synonym
type: AnnotationProperty
textual definition: An alternative label for a class or property which has the exact same meaning than the preferred name/primary label.
textual definition: Fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software.
definition editor: http://orcid.org/0000-0001-5208-3432
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/20
has_exact_synonym: FULL_SYN
has_exact_synonym: Synonym with Source Data
label: has exact synonym

has_narrow_synonym
type: AnnotationProperty
textual definition: An alternative label for a class or property which has a more specific meaning than the preferred name/primary label.
definition editor: http://orcid.org/0000-0001-5208-3432
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/19
label: has narrow synonym

has_obo_format_version
type: AnnotationProperty

has_obo_namespace
type: AnnotationProperty

has_related_synonym
type: AnnotationProperty
textual definition: An alternative label for a class or property that has been used synonymously with the primary term name, but the usage is not strictly correct.
definition editor: http://orcid.org/0000-0001-5208-3432
term tracker item: https://github.com/information-artifact-ontology/ontology-metadata/issues/21
label: has related synonym

id
type: AnnotationProperty

in subset
type: AnnotationProperty
textual definition: Used to associate the concept defining a particular terminology subset with concepts that belong to this subset.
has_exact_synonym: Concept_In_Subset
label: in_subset

shorthand
type: AnnotationProperty

label
type: AnnotationProperty
editor preferred label: label

see also
type: AnnotationProperty
has_obo_namespace: uberon
id: seeAlso
is class level: true
is metadata tag: true
shorthand: seeAlso
label: seeAlso

depicted_by
type: AnnotationProperty
has_obo_namespace: uberon
id: foaf-depicted_by
is metadata tag: 1
shorthand: foaf-depicted_by

depiction
type: AnnotationProperty
has_obo_namespace: uberon
id: depiction
is metadata tag: true
shorthand: depiction

CI_ChemClass
type: ObjectProperty
range: Chemical Ingredients [Chemical/Ingredient]
code: C26
imported from: NDF-RT.owl

CI_with
type: ObjectProperty
range: Diseases, Manifestations or Physiologic States [Disease/Finding]
code: C36
imported from: NDF-RT.owl

has_Ingredient
type: ObjectProperty
range: Chemical Ingredients [Chemical/Ingredient]
code: C24
imported from: NDF-RT.owl

has_MoA
type: ObjectProperty
range: Cellular or Molecular Interactions [MoA]
code: C28
imported from: NDF-RT.owl

has_PE
type: ObjectProperty
range: Physiological Effects [PE]
code: C20
imported from: NDF-RT.owl

has_PK
type: ObjectProperty
range: Clinical Kinetics [PK]
code: C32
imported from: NDF-RT.owl

induces
type: ObjectProperty
range: Diseases, Manifestations or Physiologic States [Disease/Finding]
code: C40
imported from: NDF-RT.owl

may_prevent
type: ObjectProperty
range: Diseases, Manifestations or Physiologic States [Disease/Finding]
code: C38
imported from: NDF-RT.owl

may_treat
type: ObjectProperty
range: Diseases, Manifestations or Physiologic States [Disease/Finding]
code: C34
imported from: NDF-RT.owl

part of
type: ObjectProperty
sub property of: overlaps
inverse of: has part
type: TransitiveProperty
editor preferred label: is part of
example of usage: my brain is part of my body (continuant parthood, two material entities)
example of usage: my stomach cavity is part of my stomach (continuant parthood, immaterial entity is part of material entity)
example of usage: this day is part of this year (occurrent parthood)
textual definition: a core relation that holds between a part and its whole
editor note: Everything is part of itself. Any part of any part of a thing is itself part of that thing. Two distinct things cannot be part of each other.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent can be part of an occurrent; only a process can be part of a process; only a continuant can be part of a continuant; only an independent continuant can be part of an independent continuant; only an immaterial entity can be part of an immaterial entity; only a specifically dependent continuant can be part of a specifically dependent continuant; only a generically dependent continuant can be part of a generically dependent continuant. (This list is not exhaustive.) A continuant cannot be part of an occurrent: use 'participates in'. An occurrent cannot be part of a continuant: use 'has participant'. A material entity cannot be part of an immaterial entity: use 'has location'. A specifically dependent continuant cannot be part of an independent continuant: use 'inheres in'. An independent continuant cannot be part of a specifically dependent continuant: use 'bearer of'.
alternative term: part_of
imported from: BFO
imported from: cl.owl
imported from: envo.owl
imported from: go.owl
imported from: hp.owl
imported from: iao.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: omrse.owl
imported from: pr.owl
imported from: ro.owl
imported from: uberon.owl
imported from: vo.owl
temporal interpretation: RO_0001901
RO_0040042: continuant
RO_0040042: occurrent
RO_0040042: independent continuant
RO_0040042: realizable entity
RO_0040042: quality
RO_0040042: specifically dependent continuant
RO_0040042: generically dependent continuant
database_cross_reference: BFO:0000050
has_obo_namespace: external
has_obo_namespace: protein
has_obo_namespace: quality
has_obo_namespace: uberon
id: part_of
in subset: valid for go annotation extension
in subset: valid for go gp2term
in subset: valid for go ontology
in subset: valid for gocam
shorthand: part_of
label: part_of

has part
type: ObjectProperty
equivalent property:
  inverse of: part of
sub property of: overlaps
sub property of: determined by
type: TransitiveProperty
editor preferred label: has part
example of usage: my body has part my brain (continuant parthood, two material entities)
example of usage: my stomach has part my stomach cavity (continuant parthood, material entity has part immaterial entity)
example of usage: this year has part this day (occurrent parthood)
textual definition: Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2.
textual definition: a core relation that holds between a whole and its part
editor note: Everything has itself as a part. Any part of any part of a thing is itself part of that thing. Two distinct things cannot have each other as a part.
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
editor note: Occurrents are not subject to change and so parthood between occurrents holds for all the times that the part exists. Many continuants are subject to change, so parthood between continuants will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
editor note: Parthood requires the part and the whole to have compatible classes: only an occurrent have an occurrent as part; only a process can have a process as part; only a continuant can have a continuant as part; only an independent continuant can have an independent continuant as part; only a specifically dependent continuant can have a specifically dependent continuant as part; only a generically dependent continuant can have a generically dependent continuant as part. (This list is not exhaustive.) A continuant cannot have an occurrent as part: use 'participates in'. An occurrent cannot have a continuant as part: use 'has participant'. An immaterial entity cannot have a material entity as part: use 'location of'. An independent continuant cannot have a specifically dependent continuant as part: use 'bearer of'. A specifically dependent continuant cannot have an independent continuant as part: use 'inheres in'.
alternative term: has_part
imported from: BFO
imported from: cl.owl
imported from: dron.owl
imported from: envo.owl
imported from: go.owl
imported from: hp.owl
imported from: iao.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
imported from: omrse.owl
imported from: pr.owl
imported from: ro.owl
imported from: uberon.owl
imported from: vo.owl
temporal interpretation: RO_0001901
database_cross_reference: BFO:0000051
has_obo_namespace: external
has_obo_namespace: protein
has_obo_namespace: quality
has_obo_namespace: uberon
id: has_part
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: has_part
label: has_part

inheres in at all times
type: ObjectProperty
sub property of: specifically depends on at all times
domain: specifically dependent continuant
range: Class
  intersection of: independent continuant
  intersection of: Class
    complement of: spatial region
BFO OWL specification label: inheres-in_at
BFO CLIF specification label: inheresInAt
textual definition: b inheres_in c at t =Def. b is a dependent continuant & c is an independent continuant that is not a spatial region & b s-depends_on c at t. (axiom label in BFO2 Reference: [051-002])
editor note: Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'inheres in at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'inheres in@en(x,y,t)'.
editor note: BFO 2 Reference: Inherence is a subrelation of s-depends_on which holds between a dependent continuant and an independent continuant that is not a spatial region. Since dependent continuants cannot migrate from one independent continuant bearer to another, it follows that if b s-depends_on independent continuant c at some time, then b s-depends_on c at all times at which a exists. Inherence is in this sense redundantly time-indexed.For example, consider the particular instance of openness inhering in my mouth at t as I prepare to take a bite out of a donut, followed by a closedness at t+1 when I bite the donut and start chewing. The openness instance is then shortlived, and to say that it s-depends_on my mouth at all times at which this openness exists, means: at all times during this short life. Every time you make a fist, you make a new (instance of the universal) fist. (Every time your hand has the fist-shaped quality, there is created a new instance of the universal fist-shaped quality.)
editor note: BFO2 Reference: independent continuant that is not a spatial region
editor note: BFO2 Reference: specifically dependent continuant
imported from: ogg.owl
has associated axiom(fol): (iff (inheresInAt a b t) (and (DependentContinuant a) (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))) // axiom label in BFO2 CLIF: [051-002]

is_bearer_of
type: ObjectProperty
sub property of: topObjectProperty
alternative term: bearer of
alternative term: bearer_of
imported from: dron.owl
imported from: http://purl.obolibrary.org/obo/omrse.owl
label: is bearer of

realized in
type: ObjectProperty
sub property of: topObjectProperty
inverse of: realizes
domain: realizable entity
range: process
editor preferred label: realized in
example of usage: this disease is realized in this disease course
example of usage: this fragility is realized in this shattering
example of usage: this investigator role is realized in this investigation
alternative term: is realized by
alternative term: realized_in
imported from: dron.owl
imported from: mondo.owl
imported from: obi.owl
imported from: omrse.owl
imported from: ro.owl
imported from: vo.owl
elucidation: [copied from inverse property 'realizes'] to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
database_cross_reference: BFO:0000054
id: realized_in
shorthand: realized_in
comment: Paraphrase of elucidation: a relation between a realizable entity and a process, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process

realizes
type: ObjectProperty
domain: process
range: realizable entity
TV pl: BFO_0000055
TV sg: BFO_0000055s
TV vbg: BFO_0000055ed
editor preferred label: realizes
example of usage: this disease course realizes this disease
example of usage: this investigation realizes this investigator role
example of usage: this shattering realizes this fragility
imported from: envo.owl
imported from: mondo.owl
imported from: obi.owl
imported from: obib.owl
imported from: omrse.owl
imported from: ro.owl
imported from: vo.owl
elucidation: to say that b realizes c at t is to assert that there is some material entity d & b is a process which has participant d at t & c is a disposition or role of which d is bearer_of at t& the type instantiated by b is correlated with the type instantiated by c. (axiom label in BFO2 Reference: [059-003])
comment: Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process

concretized by at some time
type: ObjectProperty
inverse of: concretizes at some time
domain: generically dependent continuant
range: specifically dependent continuant
BFO OWL specification label: concretized-by_st
example of usage: [copied from inverse property 'concretizes at some time'] You may concretize a piece of software by installing it in your computer
example of usage: [copied from inverse property 'concretizes at some time'] You may concretize a recipe that you find in a cookbook by turning it into a plan which exists as a realizable dependent continuant in your head.
example of usage: [copied from inverse property 'concretizes at some time'] you may concretize a poem as a pattern of memory traces in your head
editor note: [copied from inverse property 'concretizes at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'concretizes at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'concretizes@en'(x,y,t)
imported from: ogg.owl
elucidation: [copied from inverse property 'concretizes at some time'] b concretizes c at t means: b is a specifically dependent continuant & c is a generically dependent continuant & for some independent continuant that is not a spatial region d, b s-depends_on d at t & c g-depends on d at t & if c migrates from bearer d to another bearer e than a copy of b will be created in e. (axiom label in BFO2 Reference: [075-002])

concretizes at some time
type: ObjectProperty
domain: specifically dependent continuant
range: generically dependent continuant
BFO OWL specification label: concretizes_st
BFO CLIF specification label: concretizesAt
example of usage: You may concretize a piece of software by installing it in your computer
example of usage: You may concretize a recipe that you find in a cookbook by turning it into a plan which exists as a realizable dependent continuant in your head.
example of usage: you may concretize a poem as a pattern of memory traces in your head
editor note: Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'concretizes at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'concretizes@en'(x,y,t)
imported from: ogg.owl
elucidation: b concretizes c at t means: b is a specifically dependent continuant & c is a generically dependent continuant & for some independent continuant that is not a spatial region d, b s-depends_on d at t & c g-depends on d at t & if c migrates from bearer d to another bearer e than a copy of b will be created in e. (axiom label in BFO2 Reference: [075-002])
has associated axiom(nl): if b g-depends on c at some time t, then there is some d, such that d concretizes b at t and d s-depends_on c at t. (axiom label in BFO2 Reference: [076-001])
has associated axiom(fol): (forall (x y t) (if (concretizesAt x y t) (and (SpecificallyDependentContinuant x) (GenericallyDependentContinuant y) (exists (z) (and (IndependentContinuant z) (specificallyDependsOnAt x z t) (genericallyDependsOnAt y z t)))))) // axiom label in BFO2 CLIF: [075-002]
has associated axiom(fol): (forall (x y t) (if (genericallyDependsOnAt x y t) (exists (z) (and (concretizesAt z x t) (specificallyDependsOnAt z y t))))) // axiom label in BFO2 CLIF: [076-001]

preceded by
type: ObjectProperty
sub property of: ends after
inverse of: precedes
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: starts during
property chain axiom: happens during
editor preferred label: preceded by
textual definition: X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)
textual definition: x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
editor note: An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other.
alternative term: is preceded by
alternative term: preceded_by
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
Source: http://www.obofoundry.org/ro/#OBO_REL:preceded_by
source: http://www.obofoundry.org/ro/#OBO_REL:preceded_by
database_cross_reference: BFO:0000062
has_exact_synonym: is preceded by
has_exact_synonym: takes place after
has_obo_namespace: external
has_obo_namespace: uberon
id: preceded_by
in subset: ro-eco
shorthand: preceded_by
label: preceded_by

precedes
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
domain: occurrent
range: occurrent
property chain axiom: part of
property chain axiom: happens during
editor preferred label: precedes
textual definition: x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: BFO:0000063
has_obo_namespace: external
has_obo_namespace: uberon
id: precedes
in subset: ro-eco
shorthand: precedes

occurs in
type: ObjectProperty
inverse of: contains process
domain: occurrent
range: independent continuant
property chain axiom: part of
editor preferred label: occurs in
textual definition: b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
alternative term: occurs_in
alternative term: unfolds in
alternative term: unfolds_in
imported from: cl.owl
imported from: go.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
imported from: vo.owl
database_cross_reference: BFO:0000066
has_obo_namespace: external
id: occurs_in
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: occurs_in
comment: Paraphrase of definition: a relation between a process and an independent continuant, in which the process takes place entirely within the independent continuant

contains process
type: ObjectProperty
editor preferred label: site of
textual definition: [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
database_cross_reference: BFO:0000067
has_obo_namespace: uberon
id: contains_process
shorthand: contains_process
comment: Paraphrase of definition: a relation between an independent continuant and a process, in which the process takes place entirely within the independent continuant

specifically depends on at all times
type: ObjectProperty
sub property of: specifically depends on at some time
BFO OWL specification label: s-depends-on_at
BFO CLIF specification label: specificallyDependsOn
example of usage: A pain s-depends_on the organism that is experiencing the pain
example of usage: a gait s-depends_on the walking object. (All at some specific time.)
example of usage: a shape s-depends_on the shaped object
example of usage: one-sided s-dependence of a dependent continuant on an independent continuant: an instance of headache s-depends_on some head
example of usage: one-sided s-dependence of a dependent continuant on an independent continuant: an instance of temperature s-depends_on some organism
example of usage: one-sided s-dependence of a process on something: a process of cell death s-depends_on a cell
example of usage: one-sided s-dependence of a process on something: an instance of seeing (a relational process) s-depends_on some organism and on some seen entity, which may be an occurrent or a continuant
example of usage: one-sided s-dependence of one occurrent on another: a process of answering a question is dependent on a prior process of asking a question
example of usage: one-sided s-dependence of one occurrent on another: a process of obeying a command is dependent on a prior process of issuing a command
example of usage: one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of hitting a ball with a cricket bat
example of usage: one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of paying cash to a merchant in exchange for a bag of figs
example of usage: reciprocal s-dependence between occurrents: a process of buying and the associated process of selling
example of usage: reciprocal s-dependence between occurrents: a process of increasing the volume of a portion of gas while temperature remains constant and the associated process of decreasing the pressure exerted by the gas
example of usage: reciprocal s-dependence between occurrents: in a game of chess the process of playing with the white pieces is mutually dependent on the process of playing with the black pieces
example of usage: the one-sided dependence of an occurrent on an independent continuant: football match on the players, the ground, the ball
example of usage: the one-sided dependence of an occurrent on an independent continuant: handwave on a hand
example of usage: the three-sided reciprocal s-dependence of the hue, saturation and brightness of a color [45
example of usage: the three-sided reciprocal s-dependence of the pitch, timbre and volume of a tone [45
example of usage: the two-sided reciprocal s-dependence of the roles of husband and wife [20
editor note: Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'specifically depends on at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'specifically depends on@en(x,y,t)'.
editor note: BFO 2 Reference: An entity – for example an act of communication or a game of football – can s-depends_on more than one entity. Complex phenomena for example in the psychological and social realms (such as inferring, commanding and requesting) or in the realm of multi-organismal biological processes (such as infection and resistance), will involve multiple families of dependence relations, involving both continuants and occurrents [1, 4, 28
editor note: BFO 2 Reference: S-dependence is just one type of dependence among many; it is what, in the literature, is referred to as ‘existential dependence’ [87, 46, 65, 20
editor note: BFO 2 Reference: the relation of s-depends_on does not in every case require simultaneous existence of its relata. Note the difference between such cases and the cases of continuant universals defined historically: the act of answering depends existentially on the prior act of questioning; the human being who was baptized or who answered a question does not himself depend existentially on the prior act of baptism or answering. He would still exist even if these acts had never taken place.
editor note: BFO2 Reference: specifically dependent continuant\; process; process boundary
imported from: ogg.owl
elucidation: To say that b s-depends_on a at t is to say that b and c do not share common parts & b is of its nature such that it cannot exist unless c exists & b is not a boundary of c and b is not a site of which c is the host [64
has associated axiom(nl): If b is s-depends_on something at some time, then b is not a material entity. (axiom label in BFO2 Reference: [052-001])
has associated axiom(nl): If b s-depends_on something at t, then there is some c, which is an independent continuant and not a spatial region, such that b s-depends_on c at t. (axiom label in BFO2 Reference: [136-001])
has associated axiom(nl): If occurrent b s-depends_on some independent continuant c at t, then b s-depends_on c at every time at which b exists. (axiom label in BFO2 Reference: [015-002])
has associated axiom(nl): an entity does not s-depend_on any of its (continuant or occurrent) parts or on anything it is part of. (axiom label in BFO2 Reference: [013-002])
has associated axiom(nl): if b s-depends_on c at t & c s-depends_on d at t then b s-depends_on d at t. (axiom label in BFO2 Reference: [054-002])
has associated axiom(fol): (forall (x y t) (if (and (Entity x) (or (continuantPartOfAt y x t) (continuantPartOfAt x y t) (occurrentPartOf x y) (occurrentPartOf y x))) (not (specificallyDependsOnAt x y t)))) // axiom label in BFO2 CLIF: [013-002]
has associated axiom(fol): (forall (x y t) (if (and (Occurrent x) (IndependentContinuant y) (specificallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (specificallyDependsOnAt x y t_1))))) // axiom label in BFO2 CLIF: [015-002]
has associated axiom(fol): (forall (x y t) (if (specificallyDependsOnAt x y t) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [136-001]
has associated axiom(fol): (forall (x y z t) (if (and (specificallyDependsOnAt x y t) (specificallyDependsOnAt y z t)) (specificallyDependsOnAt x z t))) // axiom label in BFO2 CLIF: [054-002]
has associated axiom(fol): (forall (x) (if (exists (y t) (specificallyDependsOnAt x y t)) (not (MaterialEntity x)))) // axiom label in BFO2 CLIF: [052-001]

occupies spatial region at some time
type: ObjectProperty
inverse of: has spatial occupant at some time
domain: independent continuant
range: spatial region
BFO OWL specification label: located-at-r_st
BFO CLIF specification label: occupiesSpatialRegionAt
editor note: Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'occupies spatial region at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'occupies spatial region@en'(x,y,t)
editor note: BFO2 Reference: independent continuant
editor note: BFO2 Reference: spatial region
imported from: ogg.owl
elucidation: b occupies_spatial_region r at t means that r is a spatial region in which independent continuant b is exactly located (axiom label in BFO2 Reference: [041-002])
has associated axiom(nl): every region r is occupies_spatial_region r at all times. (axiom label in BFO2 Reference: [042-002])
has associated axiom(nl): if b occupies_spatial_region r at t & b continuant_part_of b at t, then there is some r which is continuant_part_of r at t such that b occupies_spatial_region r at t. (axiom label in BFO2 Reference: [043-001])
has associated axiom(fol): (forall (r t) (if (Region r) (occupiesSpatialRegionAt r r t))) // axiom label in BFO2 CLIF: [042-002]
has associated axiom(fol): (forall (x r t) (if (occupiesSpatialRegionAt x r t) (and (SpatialRegion r) (IndependentContinuant x)))) // axiom label in BFO2 CLIF: [041-002]
has associated axiom(fol): (forall (x y r_1 t) (if (and (occupiesSpatialRegionAt x r_1 t) (continuantPartOfAt y x t)) (exists (r_2) (and (continuantPartOfAt r_2 r_1 t) (occupiesSpatialRegionAt y r_2 t))))) // axiom label in BFO2 CLIF: [043-001]

exists at
type: ObjectProperty
inverse of: during which exists
domain: entity
range: temporal region
BFO OWL specification label: exists-at
BFO CLIF specification label: existsAt
editor note: BFO2 Reference: entity
editor note: BFO2 Reference: temporal region
imported from: ogg.owl
elucidation: b exists_at t means: b is an entity which exists at some temporal region t. (axiom label in BFO2 Reference: [118-002])

has occurrent part
type: ObjectProperty
inverse of: part of occurrent
type: TransitiveProperty
domain: occurrent
range: occurrent
TV pl: BFO_0000117
TV sg: BFO_0000117s
TV vbg: BFO_0000117ed
BFO OWL specification label: o-has-part
BFO CLIF specification label: hasOccurrentPart
example of usage: [copied from inverse property 'part of occurrent'] Mary’s 5th birthday occurrent_part_of Mary’s life
example of usage: [copied from inverse property 'part of occurrent'] The process of a footballer’s heart beating once is an occurrent part but not a temporal_part of a game of football.
example of usage: [copied from inverse property 'part of occurrent'] the first set of the tennis match occurrent_part_of the tennis match.
textual definition: b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001])
editor note: [copied from inverse property 'part of occurrent'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion.
editor note: [copied from inverse property 'part of occurrent'] BFO2 Reference: occurrent
imported from: mondo.owl
imported from: ogg.owl
elucidation: [copied from inverse property 'part of occurrent'] b occurrent_part_of c =Def. b is a part of c & b and c are occurrents. (axiom label in BFO2 Reference: [003-002])
has associated axiom(fol): (iff (hasOccurrentPart a b) (occurrentPartOf b a)) // axiom label in BFO2 CLIF: [007-001]

has proper occurrent part
type: ObjectProperty
sub property of: has occurrent part
inverse of: proper part of occurrent
type: TransitiveProperty
domain: occurrent
range: occurrent
BFO OWL specification label: o-has-ppart
BFO CLIF specification label: hasProperOccurrentPart
textual definition: [copied from inverse property 'proper part of occurrent'] b proper_occurrent_part_of c =Def. b occurrent_part_of c & b and c are not identical. (axiom label in BFO2 Reference: [005-001])
textual definition: b has_proper_occurrent_part c = Def. c proper_occurrent_part_of b. [XXX-001
imported from: ogg.owl

has spatial occupant at some time
type: ObjectProperty
domain: spatial region
range: independent continuant
BFO OWL specification label: r-location-of_st
editor note: [copied from inverse property 'occupies spatial region at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'occupies spatial region at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'occupies spatial region@en'(x,y,t)
editor note: [copied from inverse property 'occupies spatial region at some time'] BFO2 Reference: independent continuant
editor note: [copied from inverse property 'occupies spatial region at some time'] BFO2 Reference: spatial region
imported from: ogg.owl
elucidation: [copied from inverse property 'occupies spatial region at some time'] b occupies_spatial_region r at t means that r is a spatial region in which independent continuant b is exactly located (axiom label in BFO2 Reference: [041-002])

has specific dependent at some time
type: ObjectProperty
inverse of: specifically depends on at some time
domain: Class
  union of: process
  union of: specifically dependent continuant
  union of: Class
    intersection of: independent continuant
    intersection of: Class
      complement of: spatial region
range: Class
  union of: process
  union of: specifically dependent continuant
BFO OWL specification label: has-s-dep_st
example of usage: [copied from inverse property 'specifically depends on at some time'] A pain s-depends_on the organism that is experiencing the pain
example of usage: [copied from inverse property 'specifically depends on at some time'] a gait s-depends_on the walking object. (All at some specific time.)
example of usage: [copied from inverse property 'specifically depends on at some time'] a shape s-depends_on the shaped object
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a dependent continuant on an independent continuant: an instance of headache s-depends_on some head
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a dependent continuant on an independent continuant: an instance of temperature s-depends_on some organism
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a process on something: a process of cell death s-depends_on a cell
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of a process on something: an instance of seeing (a relational process) s-depends_on some organism and on some seen entity, which may be an occurrent or a continuant
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on another: a process of answering a question is dependent on a prior process of asking a question
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on another: a process of obeying a command is dependent on a prior process of issuing a command
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of hitting a ball with a cricket bat
example of usage: [copied from inverse property 'specifically depends on at some time'] one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of paying cash to a merchant in exchange for a bag of figs
example of usage: [copied from inverse property 'specifically depends on at some time'] reciprocal s-dependence between occurrents: a process of buying and the associated process of selling
example of usage: [copied from inverse property 'specifically depends on at some time'] reciprocal s-dependence between occurrents: a process of increasing the volume of a portion of gas while temperature remains constant and the associated process of decreasing the pressure exerted by the gas
example of usage: [copied from inverse property 'specifically depends on at some time'] reciprocal s-dependence between occurrents: in a game of chess the process of playing with the white pieces is mutually dependent on the process of playing with the black pieces
example of usage: [copied from inverse property 'specifically depends on at some time'] the one-sided dependence of an occurrent on an independent continuant: football match on the players, the ground, the ball
example of usage: [copied from inverse property 'specifically depends on at some time'] the one-sided dependence of an occurrent on an independent continuant: handwave on a hand
example of usage: [copied from inverse property 'specifically depends on at some time'] the three-sided reciprocal s-dependence of the hue, saturation and brightness of a color [45
example of usage: [copied from inverse property 'specifically depends on at some time'] the three-sided reciprocal s-dependence of the pitch, timbre and volume of a tone [45
example of usage: [copied from inverse property 'specifically depends on at some time'] the two-sided reciprocal s-dependence of the roles of husband and wife [20
editor note: [copied from inverse property 'specifically depends on at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'specifically depends on at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'specifically depends on@en'(x,y,t)
editor note: [copied from inverse property 'specifically depends on at some time'] BFO 2 Reference: An entity – for example an act of communication or a game of football – can s-depends_on more than one entity. Complex phenomena for example in the psychological and social realms (such as inferring, commanding and requesting) or in the realm of multi-organismal biological processes (such as infection and resistance), will involve multiple families of dependence relations, involving both continuants and occurrents [1, 4, 28
editor note: [copied from inverse property 'specifically depends on at some time'] BFO 2 Reference: S-dependence is just one type of dependence among many; it is what, in the literature, is referred to as ‘existential dependence’ [87, 46, 65, 20
editor note: [copied from inverse property 'specifically depends on at some time'] BFO 2 Reference: the relation of s-depends_on does not in every case require simultaneous existence of its relata. Note the difference between such cases and the cases of continuant universals defined historically: the act of answering depends existentially on the prior act of questioning; the human being who was baptized or who answered a question does not himself depend existentially on the prior act of baptism or answering. He would still exist even if these acts had never taken place.
editor note: [copied from inverse property 'specifically depends on at some time'] BFO2 Reference: specifically dependent continuant\; process; process boundary
imported from: ogg.owl
elucidation: [copied from inverse property 'specifically depends on at some time'] To say that b s-depends_on a at t is to say that b and c do not share common parts & b is of its nature such that it cannot exist unless c exists & b is not a boundary of c and b is not a site of which c is the host [64

has spatiotemporal occupant
type: ObjectProperty
inverse of: occupies spatiotemporal region
domain: spatiotemporal region
range: occurrent
BFO OWL specification label: occupied-by
editor note: [copied from inverse property 'occupies spatiotemporal region'] BFO 2 Reference: The occupies_spatiotemporal_region and occupies_temporal_region relations are the counterpart, on the occurrent side, of the relation occupies_spatial_region.
imported from: ogg.owl
elucidation: [copied from inverse property 'occupies spatiotemporal region'] p occupies_spatiotemporal_region s. This is a primitive relation between an occurrent p and the spatiotemporal region s which is its spatiotemporal extent. (axiom label in BFO2 Reference: [082-003])

occupies spatiotemporal region
type: ObjectProperty
domain: occurrent
range: spatiotemporal region
BFO OWL specification label: occupies
BFO CLIF specification label: occupiesSpatiotemporalRegion
editor note: BFO 2 Reference: The occupies_spatiotemporal_region and occupies_temporal_region relations are the counterpart, on the occurrent side, of the relation occupies_spatial_region.
imported from: ogg.owl
elucidation: p occupies_spatiotemporal_region s. This is a primitive relation between an occurrent p and the spatiotemporal region s which is its spatiotemporal extent. (axiom label in BFO2 Reference: [082-003])

part of occurrent
type: ObjectProperty
type: TransitiveProperty
domain: occurrent
range: occurrent
TV pl: BFO_0000132
TV sg: BFO_0000132s
TV vbg: BFO_0000132ed
BFO OWL specification label: o-part-of
BFO CLIF specification label: occurrentPartOf
example of usage: Mary’s 5th birthday occurrent_part_of Mary’s life
example of usage: The process of a footballer’s heart beating once is an occurrent part but not a temporal_part of a game of football.
example of usage: the first set of the tennis match occurrent_part_of the tennis match.
textual definition: [copied from inverse property 'has occurrent part'] b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001])
editor note: BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion.
editor note: BFO2 Reference: occurrent
imported from: mondo.owl
imported from: ogg.owl
elucidation: b occurrent_part_of c =Def. b is a part of c & b and c are occurrents. (axiom label in BFO2 Reference: [003-002])
has associated axiom(nl): occurrent_part_of is antisymmetric. (axiom label in BFO2 Reference: [123-001])
has associated axiom(nl): occurrent_part_of is reflexive (every occurrent entity is an occurrent_part_of itself). (axiom label in BFO2 Reference: [113-002])
has associated axiom(nl): occurrent_part_of is transitive. (axiom label in BFO2 Reference: [112-001])
has associated axiom(nl): occurrent_part_of satisfies unique product. (axiom label in BFO2 Reference: [125-001])
has associated axiom(nl): occurrent_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [124-001])
has associated axiom(fol): (forall (x y t) (if (and (occurrentPartOf x y t) (not (= x y))) (exists (z) (and (occurrentPartOf z y t) (not (exists (w) (and (occurrentPartOf w x t) (occurrentPartOf w z t)))))))) // axiom label in BFO2 CLIF: [124-001]
has associated axiom(fol): (forall (x y t) (if (and (occurrentPartOf x y t) (occurrentPartOf y x t)) (= x y))) // axiom label in BFO2 CLIF: [123-001]
has associated axiom(fol): (forall (x y t) (if (exists (v) (and (occurrentPartOf v x t) (occurrentPartOf v y t))) (exists (z) (forall (u w) (iff (iff (occurrentPartOf w u t) (and (occurrentPartOf w x t) (occurrentPartOf w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [125-001]
has associated axiom(fol): (forall (x y z) (if (and (occurrentPartOf x y) (occurrentPartOf y z)) (occurrentPartOf x z))) // axiom label in BFO2 CLIF: [112-001]
has associated axiom(fol): (forall (x) (if (Occurrent x) (occurrentPartOf x x))) // axiom label in BFO2 CLIF: [113-002]

proper part of occurrent
type: ObjectProperty
sub property of: part of occurrent
type: TransitiveProperty
domain: occurrent
range: occurrent
BFO OWL specification label: o-ppart-of
BFO CLIF specification label: properOccurrentPartOf
textual definition: [copied from inverse property 'has proper occurrent part'] b has_proper_occurrent_part c = Def. c proper_occurrent_part_of b. [XXX-001
textual definition: b proper_occurrent_part_of c =Def. b occurrent_part_of c & b and c are not identical. (axiom label in BFO2 Reference: [005-001])
imported from: ogg.owl
has associated axiom(fol): (iff (properOccurrentPartOf a b) (and (occurrentPartOf a b) (not (= a b)))) // axiom label in BFO2 CLIF: [005-001]

temporal part of
type: ObjectProperty
sub property of: part of occurrent
type: TransitiveProperty
domain: occurrent
range: occurrent
BFO OWL specification label: t-part-of
BFO CLIF specification label: temporalPartOf
example of usage: the 4th year of your life is a temporal part of your life\. The first quarter of a game of football is a temporal part of the whole game\. The process of your heart beating from 4pm to 5pm today is a temporal part of the entire process of your heart beating.\ The 4th year of your life is a temporal part of your life
example of usage: the process boundary which separates the 3rd and 4th years of your life.
example of usage: your heart beating from 4pm to 5pm today is a temporal part of the process of your heart beating
textual definition: b proper_temporal_part_of c =Def. b temporal_part_of c & not (b = c). (axiom label in BFO2 Reference: [116-001])
textual definition: b temporal_part_of c =Def.b occurrent_part_of c & & for some temporal region t, b occupies_temporal_region t & for all occurrents d, t (if d occupies_temporal_region t & t? occurrent_part_of t then (d occurrent_part_of a iff d occurrent_part_of b)). (axiom label in BFO2 Reference: [078-003])
imported from: ogg.owl
has associated axiom(nl): if b proper_temporal_part_of c, then there is some d which is a proper_temporal_part_of c and which shares no parts with b. (axiom label in BFO2 Reference: [117-002])
has associated axiom(fol): (forall (x y) (if (properTemporalPartOf x y) (exists (z) (and (properTemporalPartOf z y) (not (exists (w) (and (temporalPartOf w x) (temporalPartOf w z)))))))) // axiom label in BFO2 CLIF: [117-002]
has associated axiom(fol): (iff (properTemporalPartOf a b) (and (temporalPartOf a b) (not (= a b)))) // axiom label in BFO2 CLIF: [116-001]
has associated axiom(fol): (iff (temporalPartOf a b) (and (occurrentPartOf a b) (exists (t) (and (TemporalRegion t) (occupiesSpatioTemporalRegion a t))) (forall (c t_1) (if (and (Occurrent c) (occupiesSpatioTemporalRegion c t_1) (occurrentPartOf t_1 r)) (iff (occurrentPartOf c a) (occurrentPartOf c b)))))) // axiom label in BFO2 CLIF: [078-003]

projects onto spatial region at some time
type: ObjectProperty
inverse of: spatial projection of spatiotemporal at some time
domain: spatiotemporal region
range: spatial region
BFO OWL specification label: st-projects-onto-s_st
imported from: ogg.owl

spatial projection of spatiotemporal at some time
type: ObjectProperty
domain: spatial region
range: spatiotemporal region
BFO OWL specification label: s-projection-of-st_st
imported from: ogg.owl

projects onto temporal region
type: ObjectProperty
sub property of: exists at
inverse of: temporal projection of spatiotemporal
domain: spatiotemporal region
range: temporal region
BFO OWL specification label: st-projects-onto-t
imported from: ogg.owl

temporal projection of spatiotemporal
type: ObjectProperty
sub property of: during which exists
domain: temporal region
range: spatiotemporal region
BFO OWL specification label: t-projection-of-st
imported from: ogg.owl

occupies temporal region
type: ObjectProperty
sub property of: exists at
inverse of: has temporal occupant
domain: occurrent
range: temporal region
BFO OWL specification label: spans
BFO CLIF specification label: occupiesTemporalRegion
imported from: ogg.owl
elucidation: p occupies_temporal_region t. This is a primitive relation between an occurrent p and the temporal region t upon which the spatiotemporal region p occupies_spatiotemporal_region projects. (axiom label in BFO2 Reference: [132-001])

has temporal occupant
type: ObjectProperty
sub property of: during which exists
domain: temporal region
range: occurrent
BFO OWL specification label: span-of
BFO CLIF specification label: spanOf
imported from: obib.owl
imported from: ogg.owl
imported from: bfo.owl
elucidation: [copied from inverse property 'occupies temporal region'] p occupies_temporal_region t. This is a primitive relation between an occurrent p and the temporal region t upon which the spatiotemporal region p occupies_spatiotemporal_region projects. (axiom label in BFO2 Reference: [132-001])

during which exists
type: ObjectProperty
domain: temporal region
range: entity
BFO OWL specification label: during-which-exists
editor note: [copied from inverse property 'exists at'] BFO2 Reference: entity
editor note: [copied from inverse property 'exists at'] BFO2 Reference: temporal region
imported from: ogg.owl
elucidation: [copied from inverse property 'exists at'] b exists_at t means: b is an entity which exists at some temporal region t. (axiom label in BFO2 Reference: [118-002])

bearer of at all times
type: ObjectProperty
sub property of: has specific dependent at all times
domain: Class
  intersection of: independent continuant
  intersection of: Class
    complement of: spatial region
range: specifically dependent continuant
BFO OWL specification label: bearer-of_at
BFO CLIF specification label: bearerOfAt
textual definition: b bearer_of c at t =Def. c s-depends_on b at t & b is an independent continuant that is not a spatial region. (axiom label in BFO2 Reference: [053-004])
editor note: Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'bearer of at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'bearer of@en(x,y,t)'.
editor note: BFO2 Reference: independent continuant that is not a spatial region
editor note: BFO2 Reference: specifically dependent continuant
imported from: ogg.owl
has associated axiom(fol): (iff (bearerOfAt a b t) (and (specificallyDependsOnAt b a t) (IndependentContinuant a) (not (SpatialRegion a)) (existsAt b t))) // axiom label in BFO2 CLIF: [053-004]

has disposition at all times
type: ObjectProperty
sub property of: bearer of at all times
range: disposition
BFO OWL specification label: has-d_at
BFO CLIF specification label: hasDispositionAt
textual definition: a has_disposition b at t =Def. b disposition_of a at t. (axiom label in BFO2 Reference: [069-001])
editor note: Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has disposition at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has disposition@en(x,y,t)'.
imported from: ogg.owl
has associated axiom(fol): (iff (hasDispositionAt a b t) (dispositionOf b a t)) // axiom label in BFO2 CLIF: [069-001]

has participant at all times
type: ObjectProperty
TV pl: BFO_0000167
TV sg: BFO_0000167s
TV vbg: BFO_0000167ed
imported from: mondo.owl

has specific dependent at all times
type: ObjectProperty
sub property of: has specific dependent at some time
BFO OWL specification label: has-s-dep_at
imported from: ogg.owl

specifically depends on at some time
type: ObjectProperty
domain: Class
  union of: process
  union of: specifically dependent continuant
range: Class
  union of: process
  union of: specifically dependent continuant
  union of: Class
    intersection of: independent continuant
    intersection of: Class
      complement of: spatial region
BFO OWL specification label: s-depends-on_st
BFO CLIF specification label: specificallyDependsOn
example of usage: A pain s-depends_on the organism that is experiencing the pain
example of usage: a gait s-depends_on the walking object. (All at some specific time.)
example of usage: a shape s-depends_on the shaped object
example of usage: one-sided s-dependence of a dependent continuant on an independent continuant: an instance of headache s-depends_on some head
example of usage: one-sided s-dependence of a dependent continuant on an independent continuant: an instance of temperature s-depends_on some organism
example of usage: one-sided s-dependence of a process on something: a process of cell death s-depends_on a cell
example of usage: one-sided s-dependence of a process on something: an instance of seeing (a relational process) s-depends_on some organism and on some seen entity, which may be an occurrent or a continuant
example of usage: one-sided s-dependence of one occurrent on another: a process of answering a question is dependent on a prior process of asking a question
example of usage: one-sided s-dependence of one occurrent on another: a process of obeying a command is dependent on a prior process of issuing a command
example of usage: one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of hitting a ball with a cricket bat
example of usage: one-sided s-dependence of one occurrent on multiple independent continuants: a relational process of paying cash to a merchant in exchange for a bag of figs
example of usage: reciprocal s-dependence between occurrents: a process of buying and the associated process of selling
example of usage: reciprocal s-dependence between occurrents: a process of increasing the volume of a portion of gas while temperature remains constant and the associated process of decreasing the pressure exerted by the gas
example of usage: reciprocal s-dependence between occurrents: in a game of chess the process of playing with the white pieces is mutually dependent on the process of playing with the black pieces
example of usage: the one-sided dependence of an occurrent on an independent continuant: football match on the players, the ground, the ball
example of usage: the one-sided dependence of an occurrent on an independent continuant: handwave on a hand
example of usage: the three-sided reciprocal s-dependence of the hue, saturation and brightness of a color [45
example of usage: the three-sided reciprocal s-dependence of the pitch, timbre and volume of a tone [45
example of usage: the two-sided reciprocal s-dependence of the roles of husband and wife [20
editor note: Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'specifically depends on at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'specifically depends on@en'(x,y,t)
editor note: BFO 2 Reference: An entity – for example an act of communication or a game of football – can s-depends_on more than one entity. Complex phenomena for example in the psychological and social realms (such as inferring, commanding and requesting) or in the realm of multi-organismal biological processes (such as infection and resistance), will involve multiple families of dependence relations, involving both continuants and occurrents [1, 4, 28
editor note: BFO 2 Reference: S-dependence is just one type of dependence among many; it is what, in the literature, is referred to as ‘existential dependence’ [87, 46, 65, 20
editor note: BFO 2 Reference: the relation of s-depends_on does not in every case require simultaneous existence of its relata. Note the difference between such cases and the cases of continuant universals defined historically: the act of answering depends existentially on the prior act of questioning; the human being who was baptized or who answered a question does not himself depend existentially on the prior act of baptism or answering. He would still exist even if these acts had never taken place.
editor note: BFO2 Reference: specifically dependent continuant\; process; process boundary
imported from: ogg.owl
elucidation: To say that b s-depends_on a at t is to say that b and c do not share common parts & b is of its nature such that it cannot exist unless c exists & b is not a boundary of c and b is not a site of which c is the host [64
has associated axiom(nl): If b is s-depends_on something at some time, then b is not a material entity. (axiom label in BFO2 Reference: [052-001])
has associated axiom(nl): If b s-depends_on something at t, then there is some c, which is an independent continuant and not a spatial region, such that b s-depends_on c at t. (axiom label in BFO2 Reference: [136-001])
has associated axiom(nl): If occurrent b s-depends_on some independent continuant c at t, then b s-depends_on c at every time at which b exists. (axiom label in BFO2 Reference: [015-002])
has associated axiom(nl): an entity does not s-depend_on any of its (continuant or occurrent) parts or on anything it is part of. (axiom label in BFO2 Reference: [013-002])
has associated axiom(nl): if b s-depends_on c at t & c s-depends_on d at t then b s-depends_on d at t. (axiom label in BFO2 Reference: [054-002])
has associated axiom(fol): (forall (x y t) (if (and (Entity x) (or (continuantPartOfAt y x t) (continuantPartOfAt x y t) (occurrentPartOf x y) (occurrentPartOf y x))) (not (specificallyDependsOnAt x y t)))) // axiom label in BFO2 CLIF: [013-002]
has associated axiom(fol): (forall (x y t) (if (and (Occurrent x) (IndependentContinuant y) (specificallyDependsOnAt x y t)) (forall (t_1) (if (existsAt x t_1) (specificallyDependsOnAt x y t_1))))) // axiom label in BFO2 CLIF: [015-002]
has associated axiom(fol): (forall (x y t) (if (specificallyDependsOnAt x y t) (exists (z) (and (IndependentContinuant z) (not (SpatialRegion z)) (specificallyDependsOnAt x z t))))) // axiom label in BFO2 CLIF: [136-001]
has associated axiom(fol): (forall (x y z t) (if (and (specificallyDependsOnAt x y t) (specificallyDependsOnAt y z t)) (specificallyDependsOnAt x z t))) // axiom label in BFO2 CLIF: [054-002]
has associated axiom(fol): (forall (x) (if (exists (y t) (specificallyDependsOnAt x y t)) (not (MaterialEntity x)))) // axiom label in BFO2 CLIF: [052-001]

part of continuant at some time
type: ObjectProperty
inverse of: has continuant part at some time
domain: continuant
range: continuant
BFO OWL specification label: c-part-of_st
BFO CLIF specification label: continuantPartOfAt
example of usage: Mary’s arm continuant_part_of Mary in the time of her life prior to her operation
example of usage: the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists.
textual definition: [copied from inverse property 'has continuant part at some time'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001])
editor note: Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'part of continuant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'part of continuant@en'(x,y,t)
editor note: BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001])
editor note: BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion.
editor note: BFO2 Reference: continuant
editor note: BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region.
editor note: [copied from inverse property 'has continuant part at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has continuant part at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has continuant part@en'(x,y,t)
imported from: ogg.owl
elucidation: b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001])
has associated axiom(nl): continuant_part_of is antisymmetric. (axiom label in BFO2 Reference: [120-001])
has associated axiom(nl): continuant_part_of is reflexive (every continuant entity is a continuant_part_of itself). (axiom label in BFO2 Reference: [111-002])
has associated axiom(nl): continuant_part_of is transitive. (axiom label in BFO2 Reference: [110-001])
has associated axiom(nl): continuant_part_of satisfies unique product. (axiom label in BFO2 Reference: [122-001])
has associated axiom(nl): continuant_part_of satisfies weak supplementation. (axiom label in BFO2 Reference: [121-001])
has associated axiom(nl): if b continuant_part_of c at t and b is an independent continuant, then b is located_in c at t. (axiom label in BFO2 Reference: [047-002])
has associated axiom(fol): (forall (x t) (if (Continuant x) (continuantPartOfAt x x t))) // axiom label in BFO2 CLIF: [111-002]
has associated axiom(fol): (forall (x y t) (if (and (continuantPartOfAt x y t) (IndependentContinuant x)) (locatedInAt x y t))) // axiom label in BFO2 CLIF: [047-002]
has associated axiom(fol): (forall (x y t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y x t)) (= x y))) // axiom label in BFO2 CLIF: [120-001]
has associated axiom(fol): (forall (x y t) (if (and (continuantPartOfAt x y t) (not (= x y))) (exists (z) (and (continuantPartOfAt z y t) (not (exists (w) (and (continuantPartOfAt w x t) (continuantPartOfAt w z t)))))))) // axiom label in BFO2 CLIF: [121-001]
has associated axiom(fol): (forall (x y t) (if (exists (v) (and (continuantPartOfAt v x t) (continuantPartOfAt v y t))) (exists (z) (forall (u w) (iff (iff (continuantPartOfAt w u t) (and (continuantPartOfAt w x t) (continuantPartOfAt w y t))) (= z u)))))) // axiom label in BFO2 CLIF: [122-001]
has associated axiom(fol): (forall (x y z t) (if (and (continuantPartOfAt x y t) (continuantPartOfAt y z t)) (continuantPartOfAt x z t))) // axiom label in BFO2 CLIF: [110-001]
has associated axiom(fol): (iff (ImmaterialEntity a) (and (IndependentContinuant a) (not (exists (b t) (and (MaterialEntity b) (continuantPartOfAt b a t)))))) // axiom label in BFO2 CLIF: [028-001]

has continuant part at some time
type: ObjectProperty
domain: continuant
range: continuant
BFO OWL specification label: c-has-part_st
BFO CLIF specification label: hasContinuantPartAt
example of usage: [copied from inverse property 'part of continuant at some time'] Mary’s arm continuant_part_of Mary in the time of her life prior to her operation
example of usage: [copied from inverse property 'part of continuant at some time'] the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists.
textual definition: b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001])
editor note: Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'has continuant part at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'has continuant part@en'(x,y,t)
editor note: [copied from inverse property 'part of continuant at some time'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance level, relation. The BFO reading of the binary relation 'part of continuant at some time@en' is: exists t, exists_at(x,t) & exists_at(y,t) & 'part of continuant@en'(x,y,t)
editor note: [copied from inverse property 'part of continuant at some time'] BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001])
editor note: [copied from inverse property 'part of continuant at some time'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion.
editor note: [copied from inverse property 'part of continuant at some time'] BFO2 Reference: continuant
editor note: [copied from inverse property 'part of continuant at some time'] BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region.
imported from: ogg.owl
elucidation: [copied from inverse property 'part of continuant at some time'] b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001])
has associated axiom(fol): (iff (hasContinuantPartAt a b t) (continuantPartOfAt b a t)) // axiom label in BFO2 CLIF: [006-001]

part of continuant at all times that whole exists
type: ObjectProperty
sub property of: part of continuant at some time
type: TransitiveProperty
domain: continuant
range: continuant
BFO OWL specification label: c-part-of-object_at
textual definition: [copied from inverse property 'has continuant part at all times'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001])
textual definition: forall(t) exists_at(y,t) -> exists_at(x,t) and 'part of continuant'(x,y,t)
editor note: This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'has continuant part at all times'
editor note: [copied from inverse property 'has continuant part at all times'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'has continuant part at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'has continuant part@en(x,y,t)'.
imported from: ogg.owl

has continuant part at all times that part exists
type: ObjectProperty
sub property of: has continuant part at some time
type: TransitiveProperty
domain: continuant
range: continuant
BFO OWL specification label: c-has-part-object_at
example of usage: [copied from inverse property 'part of continuant at all times'] Mary’s arm continuant_part_of Mary in the time of her life prior to her operation
example of usage: [copied from inverse property 'part of continuant at all times'] the Northern hemisphere of the planet Earth is a part of the planet Earth at all times at which the planet Earth exists.
textual definition: forall(t) exists_at(y,t) -> exists_at(x,t) and 'has continuant part'(x,y,t)
editor note: This is a binary version of a ternary time-indexed, instance level, relation. Unlike the rest of the temporalized relations which temporally quantify over existence of the subject of the relation, this relation temporally quantifies over the existence of the object of the relation. The relation is provided tentatively, to assess whether the GO needs such a relation. It is inverse of 'part of continuant at all times'
editor note: [copied from inverse property 'part of continuant at all times'] Alan Ruttenberg: This is a binary version of a ternary time-indexed, instance-level, relation. The BFO reading of the binary relation 'part of continuant at all times@en' is: forall(t) exists_at(x,t) -> exists_at(y,t) and 'part of continuant@en(x,y,t)'.
editor note: [copied from inverse property 'part of continuant at all times'] BFO 2 Reference: Immaterial entities are in some cases continuant parts of their material hosts. Thus the hold of a ship, for example, is a part of the ship; it may itself have parts, which may have names (used for example by ship stow planners, customs inspectors, and the like). Immaterial entities under both 1. and 2. can be of zero, one, two or three dimensions. We define:a(immaterial entity)[Definition: a is an immaterial entity = Def. a is an independent continuant that has no material entities as parts. (axiom label in BFO2 Reference: [028-001])
editor note: [copied from inverse property 'part of continuant at all times'] BFO 2 Reference: a (continuant or occurrent) part of itself. We appreciate that this is counterintuitive for some users, since it implies for example that President Obama is a part of himself. However it brings benefits in simplifying the logical formalism, and it captures an important feature of identity, namely that it is the limit case of mereological inclusion.
editor note: [copied from inverse property 'part of continuant at all times'] BFO2 Reference: continuant
editor note: [copied from inverse property 'part of continuant at all times'] BFO2 Reference: continuantThe range for ‘t’ (as in all cases throughout this document unless otherwise specified) is: temporal region.
imported from: ogg.owl
elucidation: [copied from inverse property 'part of continuant at all times'] b continuant_part_of c at t =Def. b is a part of c at t & t is a time & b and c are continuants. (axiom label in BFO2 Reference: [002-001])

anterior to
type: ObjectProperty
type: TransitiveProperty
textual definition: x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
created by: cjm
creation date: 2009-07-31T02:15:46Z
database_cross_reference: BSPO:0000096
has_obo_namespace: uberon
id: anterior_to
shorthand: anterior_to
label: anterior_to

distal to
type: ObjectProperty
textual definition: x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal).
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BSPO:0000097
has_obo_namespace: uberon
id: distal_to
shorthand: distal_to
label: distal_to

dorsal to
type: ObjectProperty
inverse of: ventral to
type: TransitiveProperty
textual definition: x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000098
has_obo_namespace: uberon
id: dorsal_to
shorthand: dorsal_to
label: dorsal_to

posterior_to
type: ObjectProperty
type: TransitiveProperty
textual definition: x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail.
imported from: mondo.owl
has_narrow_synonym: caudal_to

proximal_to
type: ObjectProperty
textual definition: x proximal_to y iff x is closer to the point of attachment with the body than y.
imported from: mondo.owl

ventral to
type: ObjectProperty
type: TransitiveProperty
textual definition: x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000102
has_obo_namespace: uberon
id: ventral_to
shorthand: ventral_to
label: ventral_to

deep_to
type: ObjectProperty
type: TransitiveProperty
textual definition: Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines.
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000107
has_obo_namespace: uberon
id: deep_to
shorthand: deep_to

superficial_to
type: ObjectProperty
textual definition: Near the outer surface of the organism. Thus, skin is superficial to the muscle layer.
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000108
has_obo_namespace: uberon
id: superficial_to
shorthand: superficial_to

in left side of
type: ObjectProperty
sub property of: in lateral side of
textual definition: X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion.
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BSPO:0000120
id: in_left_side_of
shorthand: in_left_side_of
label: in_left_side_of

in right side of
type: ObjectProperty
sub property of: in lateral side of
textual definition: X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion.
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: BSPO:0000121
has_obo_namespace: uberon
id: in_right_side_of
shorthand: in_right_side_of
label: in_right_side_of

in_posterior_side_of
type: ObjectProperty
sub property of: part of
textual definition: X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion.
imported from: mondo.owl

in_anterior_side_of
type: ObjectProperty
sub property of: part of
textual definition: X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion.
imported from: mondo.owl

in_proximal_side_of
type: ObjectProperty
sub property of: part of
inverse of: in_distal_side_of
textual definition: X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion.
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000124
has_obo_namespace: uberon
id: in_proximal_side_of
shorthand: in_proximal_side_of

in_distal_side_of
type: ObjectProperty
sub property of: part of
textual definition: X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion.
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000125
has_obo_namespace: uberon
id: in_distal_side_of
shorthand: in_distal_side_of

in lateral side of
type: ObjectProperty
sub property of: part of
property disjoint with: in_central_side_of
textual definition: X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0000126
has_obo_namespace: uberon
id: in_lateral_side_of
shorthand: in_lateral_side_of
label: in_lateral_side_of

proximalmost part of
type: ObjectProperty
sub property of: in_proximal_side_of
textual definition: X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: BSPO:0001106
has_obo_namespace: uberon
id: proximalmost_part_of
shorthand: proximalmost_part_of
label: proximalmost_part_of

immediately_deep_to
type: ObjectProperty
sub property of: deep_to
sub property of: adjacent to
textual definition: This relation holds when both the deep_to and ajdacent_to relationship similarly hold.
imported from: mondo.owl

distalmost part of
type: ObjectProperty
sub property of: in_distal_side_of
textual definition: X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BSPO:0001108
has_obo_namespace: uberon
id: distalmost_part_of
shorthand: distalmost_part_of
label: distalmost_part_of

has_not_completed
type: ObjectProperty
imported from: cl.owl

lacks_part
type: ObjectProperty
imported from: cl.owl
imported from: hp.owl
expand expression to: http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y

lacks_plasma_membrane_part
type: ObjectProperty
imported from: cl.owl
imported from: hp.owl
expand expression to: http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)

results in fission of
type: ObjectProperty
sub property of: has participant
imported from: cl.owl
database_cross_reference: GOREL:0002004
has_obo_namespace: external
id: results_in_fission_of
shorthand: results_in_fission_of
label: results_in_fission_of

has measurement unit label
type: ObjectProperty
sub property of: has part
type: FunctionalProperty
range: IAO_0000003
imported from: iao.owl

is about
type: ObjectProperty
domain: IAO_0000030
example of usage: This document is about information artifacts and their representations
has curation status: IAO_0000125
textual definition: A (currently) primitive relation that relates an information artifact to an entity.
textual definition: is_about is a (currently) primitive relation that relates an information artifact to an entity.
editor note: 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. We will try to build it back up by elaborating the various subproperties that are more precisely defined. Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic.
definition editor: person:Alan Ruttenberg
definition source: Smith, Ceusters, Ruttenberg, 2000 years of philosophy
imported from: iao.owl
imported from: mondo.owl
imported from: obi.owl
imported from: obib.owl
imported from: omrse.owl
imported from: vo.owl

denotes
type: ObjectProperty
sub property of: is about
inverse of: denoted by
domain: IAO_0000030
range: entity
example of usage: A person's name denotes the person. A variable name in a computer program denotes some piece of memory. Lexically equivalent strings can denote different things, for instance "Alan" can denote different people. In each case of use, there is a case of the denotation relation obtaining, between "Alan" and the person that is being named.
textual definition: A primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically
textual definition: denotes is a primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically
editor note: 2009-11-10 Alan Ruttenberg. Old definition said the following to emphasize the generic nature of this relation. We no longer have 'specifically denotes', which would have been primitive, so make this relation primitive. g denotes r =def r is a portion of reality there is some c that is a concretization of g every c that is a concretization of g specifically denotes r
definition editor: person:Alan Ruttenberg
definition source: Conversations with Barry Smith, Werner Ceusters, Bjoern Peters, Michel Dumontier, Melanie Courtot, James Malone, Bill Hogan
imported from: iao.owl
imported from: obi.owl
imported from: omrse.owl

denoted by
type: ObjectProperty
domain: entity
range: IAO_0000030
textual definition: inverse of the relation 'denotes'
definition editor: Person: Jie Zheng, Chris Stoeckert, Mike Conlon
term tracker item: https://github.com/information-artifact-ontology/IAO/issues/206
imported from: obi.owl

is duration of
type: ObjectProperty
sub property of: is about
domain: IAO_0000416
range: process
has curation status: IAO_0000120
textual definition: relates a process to a time-measurement-datum that represents the duration of the process
definition editor: Person:Alan Ruttenberg
imported from: iao.owl

susceptible to be differentially regulated in human disease
type: ObjectProperty
textual definition: A shortcut object property that represents a relation between a biological entity and a material entity inside a human patient where the biological entity is susceptible to be differentially regulated in the material entity (e.g., cell or anatomic entity) of a human patient with a specific disease.
definition editor: Oliver He, Edison Ong

susceptible to be differentially regulated in CKD in cell
type: ObjectProperty
sub property of: susceptible to be differentially regulated in human disease
definition editor: A shortcut object property that represents a relation between a biological entity and a cell where the entity is susceptible to be differentially regulated in a cell of a chronical kidney disease (CKD) patient.
definition editor: Oliver He, Edison Ong

susceptible to be up-regulated in CKD in cell
type: ObjectProperty
sub property of: susceptible to be differentially regulated in CKD in cell
textual definition: A shortcut object property that represents a relation between a biological entity and a cell where the entity is susceptible to be up-regulated in a cell of a chronical kidney disease (CKD) patient
definition editor: Oliver He, Edison Ong

susceptible to be down-regulated in CKD in cell
type: ObjectProperty
sub property of: susceptible to be differentially regulated in CKD in cell
textual definition: A shortcut object property that represents a relation between a biological entity and a cell where the entity is susceptible to be down-regulated in a cell of a chronical kidney disease (CKD) patient
definition editor: Oliver He, Edison Ong

susceptible to be differentially regulated in AKI in cell
type: ObjectProperty
sub property of: susceptible to be differentially regulated in human disease
textual definition: A shortcut object property that represents a relation between a biological entity and a cell where the entity is susceptible to be differentially regulated in a cell in an acute kidney injury (AKI) patient.
definition editor: Oliver He

susceptible to be differentially regulated in CKD in anatomic location
type: ObjectProperty
sub property of: susceptible to be differentially regulated in human disease
definition editor: A shortcut object property that represents a relation between a biological entity and an anatomic location where the entity is susceptible to be differentially regulated in the anatomic location of a chronical kidney disease (CKD) patient.
definition editor: Oliver He

susceptible to be up-regulated in CKD in anatomic location
type: ObjectProperty
sub property of: susceptible to be differentially regulated in CKD in anatomic location
textual definition: A shortcut object property that represents a relation between a biological entity and an anatomic location where the entity is susceptible to be up-regulated in the anatomic location of a chronical kidney disease (CKD) patient.
definition editor: Oliver He

susceptible to be down-regulated in CKD in anatomic location
type: ObjectProperty
sub property of: susceptible to be differentially regulated in CKD in anatomic location
textual definition: A shortcut object property that represents a relation between a biological entity and an anatomic location where the entity is susceptible to be down-regulated in the anatomic location of a chronical kidney disease (CKD) patient.
definition editor: Oliver He

susceptible to be differentially regulated in AKI in anatomic location
type: ObjectProperty
sub property of: susceptible to be differentially regulated in human disease
definition editor: A shortcut object property that represents a relation between a biological entity and an anatomic location where the entity is susceptible to be differentially regulated in the anatomic location of an acute kidney injury (AKI) patient.
definition editor: Oliver He, Edison Ong

susceptible to be up-regulated in AKI in cell
type: ObjectProperty
sub property of: susceptible to be differentially regulated in AKI in cell
textual definition: A shortcut object property that represents a relation between a biological entity and a cell where the entity is susceptible to be up-regulated in a cell of an acute kidney injury (AKI) patient
definition editor: Oliver He, Edison Ong

susceptible to be down-regulated in AKI in cell
type: ObjectProperty
sub property of: susceptible to be differentially regulated in AKI in cell
textual definition: A shortcut object property that represents a relation between a biological entity and a cell where the entity is susceptible to be down-regulated in a cell of an acute kidney injury (AKI) patient
definition editor: Oliver He, Edison Ong

susceptible to be down-regulated in AKI in anatomic location
type: ObjectProperty
sub property of: susceptible to be differentially regulated in AKI in anatomic location
textual definition: A shortcut object property that represents a relation between a biological entity and an anatomic location where the entity is susceptible to be down-regulated in the anatomic location of an acute kidney injury (AKI) patient.
definition editor: Oliver He

susceptible to be up-regulated in AKI in anatomic location
type: ObjectProperty
sub property of: susceptible to be differentially regulated in AKI in anatomic location
textual definition: A shortcut object property that represents a relation between a biological entity and an anatomic location where the entity is susceptible to be down-regulated in the anatomic location of an acute kidney injury (AKI) patient.
definition editor: Oliver He

is gene marker of cell
type: ObjectProperty
sub property of: is biomarker of cell
domain: OGG_0000000002
range: cell
textual definition: An object property that represents a relation between a gene and a cell type where the gene is the gene marker of the cell type
definition editor: Oliver He, Yingtong Liu

cell has gene marker
type: ObjectProperty
sub property of: biomarker related
domain: cell
range: OGG_0000000002
textual definition: An object property that represents a relation between a celltype and a gene where the cell has the gene as its gene marker
definition editor: Oliver He, Yingtong Liu

disease has biomarker
type: ObjectProperty
sub property of: biomarker related
inverse of: biomarker of disease
definition editor: Oliver He, Yingtong Liu
comment: An object property that represents a relation between a disease and a biomarker where the disease has the biomarker.

disease has gene biomarker
type: ObjectProperty
sub property of: disease has biomarker
inverse of: gene biomarker of disease
textual definition: An object property that represents a relation between a disease and a gene where the disease has the gene as a biomarker.
definition editor: Oliver He, Yingtong Liu

disease has protein biomarker
type: ObjectProperty
sub property of: disease has gene biomarker
inverse of: protein biomarker of disease
textual definition: An object property that represents a relation between a disease and a protein where the disease has the protein as a biomarker.
definition editor: Oliver He, Yingtong Liu

disease has RNA biomarker
type: ObjectProperty
sub property of: disease has gene biomarker
inverse of: RNA biomarker of disease
definition editor: An object property that represents a relation between a disease and a RNA where the disease has the mRNA as a biomarker.
definition editor: Oliver He, Yingtong Liu

biomarker of disease
type: ObjectProperty
sub property of: biomarker related
textual definition: An object property that represents a relation between a biomarker and a disease where the biomarker serves as a biomarker role for the disease
definition editor: Yingtong Liu, Oliver He

gene biomarker of disease
type: ObjectProperty
sub property of: biomarker of disease
textual definition: An object property that represents a relation between a gene and a disease where the gene is a biomarkder of the disease.
definition editor: Yingtong Liu, Oliver He

protein biomarker of disease
type: ObjectProperty
sub property of: biomarker of disease
textual definition: An object property that represents a relation between a protein and a disease where the protein is a biomarkder of the disease.
definition editor: Yingtong Liu, Oliver He

RNA biomarker of disease
type: ObjectProperty
sub property of: biomarker of disease
textual definition: An object property that represents a relation between a RNA of a gene and a disease where the mRNA expression of the gene is a biomarkder of the disease.
definition editor: Yingtong Liu, Oliver He

biomarker related
type: ObjectProperty

is biomarker of cell
type: ObjectProperty
sub property of: biomarker related

encodes protein
type: ObjectProperty
sub property of: genomically related to

has participant quality
type: ObjectProperty
example of usage: An adverse event has a participant quality, such as a hyperkalemia AE has a participatn quality blood potassium increased.
textual definition: an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality.
editor note: This is a shortcut relation of the following full version: 'has participant' some (participant 'has quality' ) in: process 'has participant' some (participant 'has quality' some quality)
definition editor: Yongqun He
imported from: oae.owl

AE occurs in
type: ObjectProperty
sub property of: occurs in
textual definition: a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in.
definition editor: Yongqun He
alternative term: adverse event occurs in
imported from: oae.owl

adverse event preceded by
type: ObjectProperty
sub property of: preceded by
domain: OAE_0000001
textual definition: a specific 'preceded by' object property that has a domain of an adverse event.
definition editor: Yongqun He
imported from: oae.owl

provides_service_consumer_with
type: ObjectProperty
sub property of: has part
domain: OBI_0001173
editor preferred label: provides_service_consumer_with
example of usage: The provides_service_consumer_with relation links the service to its primary process it provides for the consumer (as opposed to secondary processual parts of a service process such as payment or documentation). For example, a 'DNA sequencing service' provides_service_consumer_with 'DNA sequencing' as the essential process performed by the provider for the client.
has curation status: IAO_0000123
textual definition: A relation between a service and the primary processual part of the service that is performed by the provider for the consumer.
imported from: obi.owl

is_supported_by_data
type: ObjectProperty
domain: OBI_0001909
range: IAO_0000027
editor preferred label: is_supported_by_data
example of usage: The relation between the conclusion "Gene tpbA is involved in EPS production" and the data items produced using two sets of organisms, one being a tpbA knockout, the other being tpbA wildtype tested in polysacharide production assays and analyzed using an ANOVA.
has curation status: IAO_0000122
textual definition: The relation between a data item and a conclusion where the conclusion is the output of a data interpreting process and the data item is used as an input to that process
definition editor: OBI
definition source: OBI
definition source: Philly 2011 workshop
imported from: obi.owl

has_specified_input
type: ObjectProperty
equivalent property:
  inverse of: is_specified_input_of
sub property of: has participant
inverse of: is_specified_input_of
domain: OBI_0000011
editor preferred label: has_specified_input
example of usage: see is_input_of example_of_usage
has curation status: IAO_0000122
textual definition: A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.
textual definition: The inverse property of is_specified_input_of
editor note: 8/17/09: specified inputs of one process are not necessarily specified inputs of a larger process that it is part of. This is in contrast to how 'has participant' works.
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Larry Hunter
definition editor: PERSON: Melanie Coutot
imported from: obi.owl
imported from: obib.owl
imported from: omrse.owl
imported from: vo.owl

is_specified_input_of
type: ObjectProperty
sub property of: participates in
range: OBI_0000011
editor preferred label: is_specified_input_of
example of usage: some Autologous EBV(Epstein-Barr virus)-transformed B-LCL (B lymphocyte cell line) is_input_for instance of Chromum Release Assay described at https://wiki.cbil.upenn.edu/obiwiki/index.php/Chromium_Release_assay
has curation status: IAO_0000122
textual definition: A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of.
definition editor: Alan Ruttenberg
definition editor: PERSON:Bjoern Peters
imported from: obi.owl
imported from: obib.owl
imported from: vo.owl

has_specified_output
type: ObjectProperty
equivalent property:
  inverse of: is_specified_output_of
sub property of: has participant
sub property of: topObjectProperty
inverse of: is_specified_output_of
domain: OBI_0000011
editor preferred label: has_specified_output
has curation status: IAO_0000122
textual definition: A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.
textual definition: The inverse property of is_specified_output_of
definition editor: PERSON: Alan Ruttenberg
definition editor: PERSON: Bjoern Peters
definition editor: PERSON: Larry Hunter
definition editor: PERSON: Melanie Courtot
imported from: obi.owl
imported from: obib.owl
imported from: omrse.owl
imported from: vo.owl

is_manufactured_by
type: ObjectProperty
domain: material entity
range: OBI_0000835
range: Class
  union of: NCBITaxon 9606
  union of: OBI_0000245
editor preferred label: is_manufactured_by
example of usage: http://www.affymetrix.com/products/arrays/specific/hgu133.affx is_manufactered_by http://www.affymetrix.com/ (if we decide to use these URIs for the actual entities)
has curation status: IAO_0000123
textual definition: c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the "Manufacturer Role", and those people/and or machines were members or of directed by the organization to do this.
definition editor: Alan Ruttenberg
definition editor: Liju Fan
alternative term: has_make
alternative term: has_manufacturer
imported from: obi.owl
imported from: vo.owl

is_specified_output_of
type: ObjectProperty
equivalent property:
  inverse of: has_specified_output
sub property of: participates in
range: OBI_0000011
editor preferred label: is_specified_output_of
has curation status: IAO_0000122
textual definition: A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of.
definition editor: Alan Ruttenberg
definition editor: PERSON:Bjoern Peters
imported from: obi.owl
imported from: obib.owl
imported from: omrse.owl
imported from: vo.owl

achieves_planned_objective
type: ObjectProperty
inverse of: objective_achieved_by
domain: OBI_0000011
range: IAO_0000005
editor preferred label: achieves_planned_objective
example of usage: A cell sorting process achieves the objective specification 'material separation objective'
has curation status: IAO_0000120
textual definition: This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process.
definition editor: BP, AR, PPPB branch
definition source: PPPB branch derived
curator note: modified according to email thread from 1/23/09 in accordince with DT and PPPB branch
imported from: obi.owl
imported from: obib.owl
imported from: vo.owl

has grain
type: ObjectProperty
sub property of: has part
editor preferred label: has grain
has curation status: IAO_0000120
textual definition: the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car.
editor note: Discussion in Karslruhe with, among others, Alan Rector, Stefan Schulz, Marijke Keet, Melanie Courtot, and Alan Ruttenberg. Definition take from the definition of granular parthood in the cited paper. Needs work to put into standard form
definition editor: PERSON: Alan Ruttenberg
definition source: PAPER: Granularity, scale and collectivity: When size does and does not matter, Alan Rector, Jeremy Rogers, Thomas Bittner, Journal of Biomedical Informatics 39 (2006) 333-349
imported from: obi.owl

objective_achieved_by
type: ObjectProperty
domain: IAO_0000005
range: OBI_0000011
editor preferred label: objective_achieved_by
has curation status: IAO_0000122
textual definition: This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process.
definition editor: OBI
definition source: OBI
imported from: obi.owl
imported from: vo.owl

has organization member
type: ObjectProperty
domain: OBI_0000245
range: Class
  union of: NCBITaxon 9606
  union of: OBI_0000245
imported from: omrse.owl

has value specification
type: ObjectProperty
sub property of: has part
domain: IAO_0000030
range: OBI_0001933
editor preferred label: has value specification
has curation status: IAO_0000120
textual definition: A relation between an information content entity and a value specification that specifies its value.
definition editor: PERSON: James A. Overton
definition source: OBI
imported from: obi.owl

is genome of organism
type: ObjectProperty
sub property of: part of continuant at some time
textual definition: a 'part of continuant at some time' relation that incides a genome belongs to a organism.
definition editor: Yongqun He, Bin Zhao
imported from: ogg.owl

is gene of organism
type: ObjectProperty
sub property of: part of continuant at some time
domain: OGG_0000000002
range: OBI_0100026
textual definition: a relation between a gene and the organism where this gene belongs to the organism in nature. It does not include a foreign gene that is transferred to an organism by a genetic engineering method.
definition editor: Oliver He, Yue Liu
imported from: ogg.owl

is-aggregate-of
type: ObjectProperty
has obsolescence reason: BFO relation takes precedence.
imported from: omrse.owl
comment: We anticipate BFO 2.0 including and defining this relation. When it does, we will obsolete this property and declare it equivalent to the BFO 2.0 relation.
deprecated: true

executed in
type: ObjectProperty
example of usage: A kidney biopsy protocol is executed in a kidney biopsy process.
textual definition: A shortcut relation that is concretized and realized in some process.
definition editor: Jie Zheng, Oliver He

has question
type: ObjectProperty
sub property of: has part
range: OPMI_0000030
textual definition: A 'has part' object property that has the range of a textual question
definition editor: Oliver He

form generated by
type: ObjectProperty

has answer
type: ObjectProperty
textual definition: An object property that indicates a relation between a question and an answer
alternative term: has answer to question

has exclusion question
type: ObjectProperty
sub property of: has question
textual definition: An object property that represents a relation between a form and a question where the question sets up an exclusion criterion. Specifically, when the answer to the question is Yes, the candidate becomes ineligible for the participation of a study.
definition editor: Fred Dowd, Oliver He

has inclusion question
type: ObjectProperty
sub property of: has question
textual definition: An object property that represents a relation between a form and a question where the question sets up an inclusion criterion. Specifically, when the answer to the question is Yes, then the candidate fulfills a criterion for being eligible for participating in a study. Note that there might be other criteria that the candidate also need to meet in order to be fully eligible. Meanwhile, if the answer is No, the candidate may still be eligible depending on the other restriction.
definition editor: Fred Dowd, Oliver He

has process quality
type: ObjectProperty

has sex-specific susceptibility to
type: ObjectProperty
textual definition: An object property that represents a relation between a person with a biological sex and a process where the person has a specific susceptbility to a process
definition editor: Anthony Huffman, Oliver He

has increased susceptibility compared to male to
type: ObjectProperty
sub property of: has sex-specific susceptibility to
textual definition: An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to corresponding male population
definition editor: Anthony Huffman, Oliver He

has increased susceptibility compared to female to
type: ObjectProperty
sub property of: has sex-specific susceptibility to
example of usage: Male has increased susceptibility to death due to COVID-19 infection compared to female. Note that in this case, the male can mean one single male individual. however, the female here means the whole female population. It is reported that the ratio of deaths in COVID-19 infected males to females is 1·21:1 in high-income countries, but 2·8:1 in low-income countries (Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8023692/).
textual definition: An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to corresponding female population
definition editor: Anthony Huffman, Oliver He

has increased sex-specific susceptibility compared to sex baseline to
type: ObjectProperty
sub property of: has sex-specific susceptibility to
textual definition: An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to the whole population with all sexes included
definition editor: Anthony Huffman, Oliver He

has identifier
type: ObjectProperty
example of usage: A care_site has a care_site_id (OMOP: http://ohdsi.github.io/CommonDataModel/cdm54.html#CARE_SITE)
textual definition: An object property that represents a relation between an entity and its corresponding identifier that is owned by the entity.
definition editor: Oliver He, Long Tran

admitted from
type: ObjectProperty
example of usage: A patient was admitted to the hospital from home or a long-term care facility.
textual definition: An object property that represents a relation between a patient and a site from which the patient was admitted.
definition editor: Long Tran, Oliver He
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE

discharged to
type: ObjectProperty
example of usage: After a visit, a person was discharged to home or a long-term care site. Typically this applies only to visits that have a length of stay of a day or more.
textual definition: An object property that represents a relation between a patient and a site to which the patient was discharged after a visit.
definition source: http://ohdsi.github.io/CommonDataModel/cdm54.html#VISIT_OCCURRENCE

has status content
type: ObjectProperty
domain: OPMI_0000326
range: IAO_0000030
example of usage: An admission diagnosis status has the content of adimission diagnosis (as an information content entity).
textual definition: An object property that represents a relation between a status and an information content entity where the status has its content information defined by the information content entity.
definition editor: Oliver He, Long Tran

inheres in
type: ObjectProperty
equivalent property:
  inverse of: bearer of
sub property of: inheres in part of
sub property of: topObjectProperty
inverse of: bearer of
type: FunctionalProperty
editor preferred label: inheres in
example of usage: this fragility inheres in this vase
example of usage: this fragility is a characteristic of this vase
example of usage: this red color inheres in this apple
example of usage: this red color is a characteristic of this apple
textual definition: a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.
textual definition: a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence
editor note: A dependent inheres in its bearer at all times for which the dependent exists.
alternative term: 'inheres in at all times'
alternative term: inheres_in
imported from: dron.owl
imported from: envo.owl
imported from: hp.owl
imported from: obi.owl
imported from: obib.owl
imported from: omrse.owl
imported from: ro.owl
imported from: vo.owl
temporal interpretation: RO_0001901
database_cross_reference: RO:0000052
id: inheres_in
shorthand: inheres_in
comment: Note that this relation was previously called "inheres in", but was changed to be called "characteristic of" because BFO2 uses "inheres in" in a more restricted fashion. This relation differs from BFO2:inheres_in in two respects: (1) it does not impose a range constraint, and thus it allows qualities of processes, as well as of information entities, whereas BFO2 restricts inheres_in to only apply to independent continuants (2) it is declared functional, i.e. something can only be a characteristic of one thing.
label: characteristic of

bearer of
type: ObjectProperty
type: InverseFunctionalProperty
range: specifically dependent continuant
editor preferred label: bearer of
example of usage: this apple is bearer of this red color
example of usage: this vase is bearer of this fragility
textual definition: Inverse of characteristic_of
textual definition: a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence
editor note: A bearer can have many dependents, and its dependents can exist for different periods of time, but none of its dependents can exist when the bearer does not exist.
alternative term: bearer of
alternative term: bearer_of
alternative term: is bearer of
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: obi.owl
imported from: obib.owl
imported from: omrse.owl
imported from: ro.owl
imported from: vo.owl
temporal interpretation: RO_0001901
database_cross_reference: RO:0000053
has_obo_namespace: external
id: bearer_of
shorthand: bearer_of
label: bearer_of
label: has characteristic
label: is bearer of

participates in
type: ObjectProperty
inverse of: has participant
domain: continuant
range: occurrent
editor preferred label: participates in
example of usage: this blood clot participates in this blood coagulation
example of usage: this input material (or this output material) participates in this process
example of usage: this investigator participates in this investigation
textual definition: a relation between a continuant and a process, in which the continuant is somehow involved in the process
alternative term: participates_in
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: obi.owl
imported from: obib.owl
imported from: omrse.owl
imported from: ro.owl
imported from: vo.owl
database_cross_reference: RO:0000056
has_obo_namespace: external
has_obo_namespace: uberon
id: participates_in
shorthand: participates_in
label: participates_in

has participant
type: ObjectProperty
sub property of: topObjectProperty
domain: occurrent
range: continuant
property chain axiom: has part
property chain axiom: realizes
property chain axiom: inheres in
editor preferred label: has participant
example of usage: this blood coagulation has participant this blood clot
example of usage: this investigation has participant this investigator
example of usage: this process has participant this input material (or this output material)
textual definition: a relation between a process and a continuant, in which the continuant is somehow involved in the process
editor note: Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time.
alternative term: has_participant
imported from: cl.owl
imported from: dron.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: obi.owl
imported from: obib.owl
imported from: omrse.owl
imported from: ro.owl
imported from: vo.owl
Source: http://www.obofoundry.org/ro/#OBO_REL:has_participant
source: http://www.obofoundry.org/ro/#OBO_REL:has_participant
database_cross_reference: RO:0000057
has_obo_namespace: external
id: has_participant
shorthand: has_participant
label: has_participant

concretizes
type: ObjectProperty
sub property of: topObjectProperty
domain: specifically dependent continuant
range: generically dependent continuant
editor preferred label: concretizes
example of usage: A journal article is an information artifact that inheres in some number of printed journals. For each copy of the printed journal there is some quality that carries the journal article, such as a pattern of ink. The quality (a specifically dependent continuant) concretizes the journal article (a generically dependent continuant), and both depend on that copy of the printed journal (an independent continuant).
example of usage: An investigator reads a protocol and forms a plan to carry out an assay. The plan is a realizable entity (a specifically dependent continuant) that concretizes the protocol (a generically dependent continuant), and both depend on the investigator (an independent continuant). The plan is then realized by the assay (a process).
textual definition: A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant.
imported from: obi.owl
imported from: obib.owl
imported from: omrse.owl
imported from: ro.owl
imported from: vo.owl
comment: It is recommended to not use this if possible in OMRSE. According to OntoBee this relation has been obsoleted and replaced with 'concretization of at all times'. As of Dec. 2, 2013 iao-main still uses this relation.

function of
type: ObjectProperty
sub property of: inheres in
inverse of: has function
domain: function
example of usage: this catalysis function is a function of this enzyme
textual definition: a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence
editor note: A function inheres in its bearer at all times for which the function exists, however the function need not be realized at all the times that the function exists.
alternative term: function_of
alternative term: is function of
imported from: obi.owl

role of
type: ObjectProperty
sub property of: inheres in
inverse of: has role
example of usage: this investigator role is a role of this person
textual definition: a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence
editor note: A role inheres in its bearer at all times for which the role exists, however the role need not be realized at all the times that the role exists.
alternative term: is role of
alternative term: role_of
imported from: obi.owl
imported from: ro.owl
imported from: vo.owl

has function
type: ObjectProperty
sub property of: bearer of
domain: independent continuant
range: function
example of usage: this enzyme has function this catalysis function (more colloquially: this enzyme has this catalysis function)
textual definition: a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence
editor note: A bearer can have many functions, and its functions can exist for different periods of time, but none of its functions can exist when the bearer does not exist. A function need not be realized at all the times that the function exists.
alternative term: has_function
imported from: obi.owl
imported from: ro.owl
imported from: vo.owl

has quality
type: ObjectProperty
sub property of: bearer of
range: quality
example of usage: this apple has quality this red color
textual definition: a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence
editor note: A bearer can have many qualities, and its qualities can exist for different periods of time, but none of its qualities can exist when the bearer does not exist.
alternative term: has_quality
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: pr.owl
imported from: ro.owl
database_cross_reference: RO:0000086
has_obo_namespace: protein
has_obo_namespace: uberon
id: has_quality
is transitive: false
shorthand: has_quality
label: has_quality

has role
type: ObjectProperty
sub property of: bearer of
domain: independent continuant
range: role
example of usage: this person has role this investigator role (more colloquially: this person has this role of investigator)
textual definition: a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
editor note: A bearer can have many roles, and its roles can exist for different periods of time, but none of its roles can exist when the bearer does not exist. A role need not be realized at all the times that the role exists.
alternative term: has_role
imported from: hp.owl
imported from: mondo.owl
imported from: obi.owl
imported from: obib.owl
imported from: ro.owl
imported from: vo.owl
label: has_role

has disposition
type: ObjectProperty
sub property of: bearer of
textual definition: a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence
imported from: ro.owl
imported from: vo.owl

derives from
type: ObjectProperty
sub property of: topObjectProperty
inverse of: derives into
domain: independent continuant
range: independent continuant
editor preferred label: derives from
example of usage: this cell derives from this parent cell (cell division)
example of usage: this nucleus derives from this parent nucleus (nuclear division)
has curation status: IAO_0000125
textual definition: a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity
editor note: This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops from'.
alternative term: derives_from
imported from: obi.owl
imported from: ro.owl

derives into
type: ObjectProperty
example of usage: this parent cell derives into this cell (cell division)
example of usage: this parent nucleus derives into this nucleus (nuclear division)
has curation status: IAO_0000125
textual definition: a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity
editor note: This is a very general relation. More specific relations are preferred when applicable, such as 'directly develops into'. To avoid making statements about a future that may not come to pass, it is often better to use the backward-looking 'derives from' rather than the forward-looking 'derives into'.
alternative term: derives_into
imported from: obi.owl

location of
type: ObjectProperty
inverse of: located in
type: TransitiveProperty
editor preferred label: is location of
example of usage: my head is the location of my brain
example of usage: this cage is the location of this rat
textual definition: a relation between two independent continuants, the location and the target, in which the target is entirely within the location
editor note: Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
editor note: Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
alternative term: location_of
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: RO_0001901
database_cross_reference: RO:0001015
has_obo_namespace: uberon
id: location_of
shorthand: location_of
label: location_of

located in
type: ObjectProperty
type: TransitiveProperty
domain: independent continuant
domain: Class
  intersection of: independent continuant
  intersection of: Class
    complement of: spatial region
range: independent continuant
range: Class
  intersection of: independent continuant
  intersection of: Class
    complement of: spatial region
property chain axiom: part of
property chain axiom: subClassOf
editor preferred label: located in
example of usage: my brain is located in my head
example of usage: this rat is located in this cage
textual definition: a relation between two independent continuants, the target and the location, in which the target is entirely within the location
editor note: Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus
editor note: Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/
editor note: Most location relations will only hold at certain times, but this is difficult to specify in OWL. See https://code.google.com/p/obo-relations/wiki/ROAndTime
alternative term: located_in
imported from: cl.owl
imported from: envo.owl
imported from: gaz.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: ro.owl
imported from: uberon.owl
imported from: vo.owl
temporal interpretation: RO_0001901
Source: http://www.obofoundry.org/ro/#OBO_REL:located_in
source: http://www.obofoundry.org/ro/#OBO_REL:located_in
database_cross_reference: RO:0001025
has_obo_namespace: file:/Users/michaelashburner/Desktop/gaz/gaz.oboInOwl
has_obo_namespace: uberon
id: located_in
in subset: valid for go gp2term
shorthand: located_in
label: located_in
label: located_in (type level)

has 2D boundary
type: ObjectProperty
sub property of: mereotopologically related to
domain: material entity
range: immaterial entity
example of usage: my body has 2D boundary the surface of my skin
textual definition: a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity
editor note: A 2D boundary may have holes and gaps, but it must be a single connected entity, not an aggregate of several disconnected parts.
editor note: Although the boundary is two-dimensional, it exists in three-dimensional space and thus has a 3D shape.
definition editor: https://orcid.org/0000-0002-7073-9172
alternative term: has boundary
alternative term: has_2D_boundary
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: RO_0001901
database_cross_reference: RO:0002002
has_obo_namespace: uberon
id: has_boundary
shorthand: has_boundary
label: has boundary

innervated_by
type: ObjectProperty
inverse of: innervates
domain: UBERON_0000061
range: UBERON_0000122
property chain axiom: branching part of
definition editor: https://orcid.org/0000-0002-7073-9172
imported from: cl.owl
cites as authority: http://www.ncbi.nlm.nih.gov/pubmed/22402613
database_cross_reference: RO:0002005
has_obo_namespace: uberon
id: innervated_by
shorthand: innervated_by

bounding layer of
type: ObjectProperty
sub property of: part of
domain: Class
  intersection of: material entity
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0002124
range: material entity
textual definition: X outer_layer_of Y iff: . X :continuant that bearer_of some PATO:laminar . X part_of Y . exists Z :surface . X has_boundary Z . Z boundary_of Y has_boundary: http://purl.obolibrary.org/obo/RO_0002002 boundary_of: http://purl.obolibrary.org/obo/RO_0002000
definition editor: https://orcid.org/0000-0002-7073-9172
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002007
has_obo_namespace: external
has_obo_namespace: uberon
id: bounding_layer_of
in subset: ro-eco
shorthand: bounding_layer_of
comment: A relationship that applies between a continuant and its outer, bounding layer. Examples include the relationship between a multicellular organism and its integument, between an animal cell and its plasma membrane, and between a membrane bound organelle and its outer/bounding membrane.

has component activity
type: ObjectProperty
sub property of: has component process
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
created by: https://orcid.org/0000-0002-7073-9172
creation date: 2017-05-24T09:44:33Z
comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.

has component process
type: ObjectProperty
sub property of: has component
domain: process
range: process
textual definition: w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
created by: https://orcid.org/0000-0002-7073-9172
creation date: 2017-05-24T09:49:21Z

occurs across
type: ObjectProperty
sub property of: has part that occurs in
textual definition: A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization.
imported from: cl.owl
created by: https://orcid.org/0000-0002-7073-9172
creation date: 2017-07-20T17:19:37Z

has effector activity
type: ObjectProperty
sub property of: has component activity
sub property of: has_component
type: FunctionalProperty
textual definition: A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
created by: https://orcid.org/0000-0002-7073-9172
creation date: 2017-09-22T14:14:36Z
comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.

before or simultaneous with
type: ObjectProperty
sub property of: temporally related to
definition editor: David Osumi-Sutherland
alternative term: <=
imported from: cl.owl
imported from: hp.owl
imported from: oae.owl
imported from: ro.owl
in subset: ro-eco
comment: Primitive instance level timing relation between events

simultaneous with
type: ObjectProperty
sub property of: before or simultaneous with
sub property of: starts
sub property of: ends
type: SymmetricProperty
type: TransitiveProperty
textual definition: Relation between occurrents, shares start and end boundaries.
textual definition: x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time.
definition editor: https://orcid.org/0000-0002-7073-9172
definition editor: David Osumi-Sutherland
imported from: cl.owl
imported from: hp.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: RO:0002082
has_exact_synonym: coincides_with
has_exact_synonym: is_equal_to
has_obo_namespace: uberon
id: simultaneous_with
in subset: ro-eco
shorthand: simultaneous_with
comment: t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2)
label: simultaneous_with

ends after
type: ObjectProperty
sub property of: temporally related to
type: TransitiveProperty
property chain axiom: ends_during
property chain axiom: preceded by
definition editor: David Osumi-Sutherland
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
in subset: ro-eco
comment: X ends_after Y iff: end(Y) before_or_simultaneous_with end(X)

immediately preceded by
type: ObjectProperty
sub property of: preceded by
inverse of: immediately precedes
property chain axiom: starts with
property chain axiom: ends with
textual definition: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
definition editor: David Osumi-Sutherland
alternative term: starts_at_end_of
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
external_definition: A non-transitive temporal relation in which one process immediately precedes another process, such that there is no interval of time between the two processes[SIO:000251].
database_cross_reference: RO:0002087
has_exact_synonym: directly preceded by
has_exact_synonym: is directly preceded by
has_exact_synonym: is immediately preceded by
has_exact_synonym: starts_at_end_of
has_obo_namespace: external
has_obo_namespace: uberon
id: immediately_preceded_by
shorthand: immediately_preceded_by
comment: X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)
label: immediately_preceded_by

immediately precedes
type: ObjectProperty
sub property of: precedes
property chain axiom: ends with
property chain axiom: starts with
definition editor: https://orcid.org/0000-0002-7073-9172
definition editor: David Osumi-Sutherland
alternative term: ends_at_start_of
alternative term: meets
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
is direct form of: precedes
database_cross_reference: RO:0002090
has_obo_namespace: external
id: immediately_precedes
in subset: ro-eco
shorthand: immediately_precedes
comment: X immediately_precedes_Y iff: end(X) simultaneous_with start(Y)

starts during
type: ObjectProperty
sub property of: temporally related to
domain: occurrent
range: occurrent
definition editor: David Osumi-Sutherland
alternative term: io
imported from: oae.owl
imported from: ro.owl
in subset: ro-eco
comment: X starts_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (start(X) before_or_simultaneous_with end(Y))

happens during
type: ObjectProperty
sub property of: ends_during
type: TransitiveProperty
definition editor: David Osumi-Sutherland
alternative term: d
alternative term: during
imported from: envo.owl
imported from: oae.owl
imported from: ro.owl
in subset: ro-eco
comment: X happens_during Y iff: (start(Y) before_or_simultaneous_with start(X)) AND (end(X) before_or_simultaneous_with end(Y))

ends_during
type: ObjectProperty
sub property of: temporally related to
definition editor: David Osumi-Sutherland
alternative term: o
alternative term: overlaps
imported from: envo.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
in subset: ro-eco
comment: X ends_during Y iff: ((start(Y) before_or_simultaneous_with end(X)) AND end(X) before_or_simultaneous_with end(Y).
label: ends during

has soma location
type: ObjectProperty
sub property of: overlaps
domain: neuron
range: UBERON_0000465
property chain axiom: part of
has curation status: IAO_0000125
textual definition: Relation between a neuron and a material anatomical entity that its soma is part of.
definition editor: https://orcid.org/0000-0002-7073-9172
imported from: cl.owl
expand expression to: <http://purl.obolibrary.org/obo/BFO_0000051> some ( <http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
temporal interpretation: RO_0001901

has plasma membrane part
type: ObjectProperty
sub property of: has part
domain: material anatomical entity
domain: UBERON_0000465
range: material anatomical entity
range: UBERON_0000465
example of usage: Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814]
has curation status: IAO_0000125
textual definition: Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part.
definition editor: https://orcid.org/0000-0001-9990-8331
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: https://orcid.org/0000-0003-1617-8244
definition source: http://www.ncbi.nlm.nih.gov/pubmed/19243617
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
expand expression to: <http://purl.obolibrary.org/obo/BFO_0000051> some (<http://purl.obolibrary.org/obo/GO_0005886> and <http://purl.obolibrary.org/obo/BFO_0000051> some ?Y)
temporal interpretation: RO_0001901

has synaptic terminal in
type: ObjectProperty
sub property of: overlaps
domain: neuron
property chain axiom: part of
has curation status: IAO_0000125
textual definition: A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input.
definition editor: https://orcid.org/0000-0002-7073-9172
alternative term: has synapse in
imported from: cl.owl
expand expression to: <http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)
temporal interpretation: RO_0001901
cites as authority: http://www.ncbi.nlm.nih.gov/pubmed/22402613

overlaps
type: ObjectProperty
sub property of: mereotopologically related to
type: SymmetricProperty
property chain axiom: part of
property chain axiom: has part
has curation status: IAO_0000125
textual definition: A overlaps B if they share some part in common.
textual definition: x overlaps y if and only if there exists some z such that x has part z and z part of y
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
expand expression to: http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.obolibrary.org/obo/BFO_0000050 some ?Y)
temporal interpretation: RO_0001901
database_cross_reference: RO:0002131
has_obo_namespace: external
has_obo_namespace: uberon
id: overlaps
in subset: valid for go annotation extension
in subset: valid for gocam
in subset: ro-eco
shorthand: overlaps

innervates
type: ObjectProperty
sub property of: topObjectProperty
domain: neuron projection bundle
domain: UBERON_0000122
property chain axiom: part of
has curation status: IAO_0000125
textual definition: Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
definition editor: https://orcid.org/0000-0002-7073-9172
imported from: cl.owl
imported from: mondo.owl
expand expression to: <http://purl.obolibrary.org/obo/RO_0002132> some (<http://purl.obolibrary.org/obo/GO_0043005> that (<http://purl.obolibrary.org/obo/RO_0002131> some (<http://purl.obolibrary.org/obo/GO_0045202> that <http://purl.obolibrary.org/obo/BFO_0000050> some Y?)))
temporal interpretation: RO_0001901
cites as authority: http://www.ncbi.nlm.nih.gov/pubmed/22402613
database_cross_reference: RO:0002134
has_obo_namespace: uberon
id: innervates
shorthand: innervates

continuous with
type: ObjectProperty
sub property of: mereotopologically related to
type: SymmetricProperty
domain: independent continuant
range: independent continuant
has curation status: IAO_0000125
textual definition: X continuous_with Y if and only if X and Y share a fiat boundary.
definition editor: https://orcid.org/0000-0002-7073-9172
alternative term: connected to
curator note: The label for this relation was previously connected to. I relabeled this to "continuous with". The standard notion of connectedness does not imply shared boundaries - e.g. Glasgow connected_to Edinburgh via M8; my patella connected_to my femur (via patellar-femoral joint)
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
temporal interpretation: RO_0001901
database_cross_reference: RO:0002150
has_obo_namespace: uberon
id: continuous_with
shorthand: continuous_with
label: continuous_with

only in taxon
type: ObjectProperty
sub property of: in taxon
example of usage: lactation SubClassOf 'only in taxon' some 'Mammalia'
has curation status: IAO_0000125
textual definition: U only_in_taxon T: U is a feature found in only in organisms of species of taxon T. The feature cannot be found in an organism of any species outside of (not subsumed by) that taxon. Down-propagates in U hierarchy, up-propagates in T hierarchy (species taxonomy). Implies applicable_to_taxon.
textual definition: x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z.
editor note: The original intent was to treat this as a macro that expands to 'in taxon' only ?Y - however, this is not necessary if we instead have supplemental axioms that state that each pair of sibling tax have a disjointness axiom using the 'in taxon' property - e.g. 'in taxon' some Eukaryota DisjointWith 'in taxon' some Eubacteria
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: http://www.ncbi.nlm.nih.gov/pubmed/17921072
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20973947
imported from: cl.owl
imported from: mondo.owl
imported from: pr.owl
database_cross_reference: RO:0002160
has_exact_synonym: never_outside_taxon
has_exact_synonym: specific_to
has_exact_synonym: specific_to_taxon
has_obo_namespace: protein
has_obo_namespace: uberon
id: only_in_taxon
is transitive: false
shorthand: only_in_taxon
comment: Down-propagates. The original name for this in the paper is 'specific_to'. Applicable to genes because some genes are lost in sub-species (strains) of a species.
label: only_in_taxon

in taxon
type: ObjectProperty
sub property of: evolutionarily related to
range: organism or virus or viroid
property chain axiom: part of
property chain axiom: has part
property chain axiom: innervated_by
property chain axiom: overlaps
property chain axiom: continuous with
property chain axiom: connected to
property chain axiom: connects
property chain axiom: supplies
property chain axiom: develops from
property chain axiom: expressed in
property chain axiom: capable of
property chain axiom: develops from part of
property chain axiom: has developmental contribution from
property chain axiom: developmentally induced by
property chain axiom: results in developmental progression of
property chain axiom: attached to
property chain axiom: has potential to develop into
property chain axiom: existence starts during
property chain axiom: existence ends during
property chain axiom: produces
property chain axiom: produced by
property chain axiom: extends_fibers_into
has curation status: IAO_0000125
textual definition: x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed.
definition editor: 0000-0001-9227-417X
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: http://www.ncbi.nlm.nih.gov/pubmed/17921072
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20973947
imported from: cl.owl
imported from: mondo.owl
imported from: ro.owl
database_cross_reference: RO:0002162
has_obo_namespace: uberon
id: in_taxon
in subset: ro-eco
shorthand: in_taxon
comment: Connects a biological entity to its taxon of origin.

spatially disjoint from
type: ObjectProperty
sub property of: mereotopologically related to
has curation status: IAO_0000125
textual definition: A is spatially_disjoint_from B if and only if they have no parts in common
editor note: There are two ways to encode this as a shortcut relation. The other possibility to use an annotation assertion between two classes, and expand this to a disjointness axiom.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
curator note: Note that it would be possible to use the relation to label the relationship between a near infinite number of structures - between the rings of saturn and my left earlobe. The intent is that this is used for parsiomoniously for disambiguation purposes - for example, between siblings in a jointly exhaustive pairwise disjointness hierarchy
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
expand expression to: BFO_0000051 exactly 0 (BFO_0000050 some ?Y)
temporal interpretation: RO_0001901
in subset: ro-eco

connected to
type: ObjectProperty
sub property of: mereotopologically related to
sub property of: transitively_connected to
domain: Restriction
  on property: part of
  some values from: RO_0002577
range: Restriction
  on property: part of
  some values from: RO_0002577
property chain axiom:
  inverse of: connects
property chain axiom: connects
example of usage: a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones).
textual definition: Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship.
textual definition: a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002170
has_obo_namespace: uberon
id: connected_to
shorthand: connected_to

connects
type: ObjectProperty
sub property of: mereotopologically related to
domain: independent continuant
range: Restriction
  on property: part of
  some values from: RO_0002577
example of usage: The M8 connects Glasgow and Edinburgh
example of usage: a 'toe distal phalanx bone' that is connected to a 'toe medial phalanx bone' (an interphalangeal joint *connects* these two bones).
textual definition: Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.
textual definition: c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system.
editor note: this is currently used for both structural relationships (such as between a valve and the chamber it connects) and abstract relationships (anatomical lines and the entities they connect)
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002176
has_obo_namespace: uberon
id: connects
shorthand: connects

attached to part of
type: ObjectProperty
sub property of: mereotopologically related to
sub property of: biomechanically related to
domain: connected anatomical structure
domain: UBERON_0000061
range: connected anatomical structure
range: UBERON_0000061
property chain axiom: attached to
property chain axiom: part of
textual definition: a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b.
imported from: cl.owl
imported from: mondo.owl
OBO foundry unique label: attached to part of (anatomical structure to anatomical structure)
database_cross_reference: RO:0002177
has_obo_namespace: uberon
id: attaches_to_part_of
shorthand: attaches_to_part_of
label: attaches_to_part_of

supplies
type: ObjectProperty
sub property of: connected to
domain: UBERON_0001637
textual definition: Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy.
textual definition: relation between an artery and the structure is supplies with blood.
editor note: Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between an artery and an anatomical structure
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20064205
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002178
has_exact_synonym: arterial supply of
has_obo_namespace: uberon
id: supplies
shorthand: supplies

drains
type: ObjectProperty
sub property of: connected to
domain: UBERON_0001638
textual definition: Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure.
editor note: Individual ontologies should provide their own constraints on this abstract relation. For example, in the realm of anatomy this should hold between a vein and an anatomical structure
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20064205
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: RO:0002179
has_exact_synonym: drains blood from
has_exact_synonym: drains from
has_obo_namespace: uberon
id: drains
shorthand: drains

has component
type: ObjectProperty
sub property of: has part
has curation status: IAO_0000125
textual definition: w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
editor note: The definition of 'has component' is still under discussion. The challenge is in providing a definition that does not imply transitivity.
curator note: For use in recording has_part with a cardinality constraint, because OWL does not permit cardinality constraints to be used in combination with transitive object properties. In situations where you would want to say something like 'has part exactly 5 digit, you would instead use has_component exactly 5 digit.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: pr.owl
temporal interpretation: RO_0001901
database_cross_reference: RO:0002180
has_obo_namespace: external
has_obo_namespace: protein
has_obo_namespace: uberon
id: has_component
in subset: ro-eco
is transitive: false
shorthand: has_component
label: has_component

has phenotype
type: ObjectProperty
sub property of: topObjectProperty
inverse of: phenotype of
range: UPHENO_0001001
textual definition: A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype).
imported from: mondo.owl

phenotype of
type: ObjectProperty
sub property of: topObjectProperty
type: FunctionalProperty
textual definition: inverse of has phenotype
imported from: mondo.owl

develops from
type: ObjectProperty
sub property of: has developmental contribution from
sub property of: developmentally preceded by
sub property of: determined by
inverse of: develops into
type: TransitiveProperty
domain: independent continuant
range: independent continuant
property chain axiom: part of
has curation status: IAO_0000125
textual definition: x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y
definition editor: https://orcid.org/0000-0001-9114-8737
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: https://orcid.org/0000-0002-7073-9172
definition editor: https://orcid.org/0000-0003-1980-3228
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002202
has_obo_namespace: uberon
id: develops_from
shorthand: develops_from
comment: This is the transitive form of the develops from relation
label: develops_from

develops into
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to develop into
sub property of: has potential to directly develop into
type: TransitiveProperty
has curation status: IAO_0000125
textual definition: inverse of develops from
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: https://orcid.org/0000-0002-7073-9172
definition editor: https://orcid.org/0000-0003-1980-3228
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002203
has_obo_namespace: uberon
id: develops_into
in subset: RO_0002259
shorthand: develops_into
label: develops_into

expressed in
type: ObjectProperty
sub property of: genomically related to
inverse of: expresses
domain: continuant
domain: Class
  union of: generically dependent continuant
  union of: material entity
range: UBERON_0000465
property chain axiom: part of
example of usage: 'neural crest cell' SubClassOf expresses some 'Wnt1 gene'
has curation status: IAO_0000125
textual definition: x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl

directly develops from
type: ObjectProperty
sub property of: develops from
inverse of: directly develops into
domain: Class
  union of: multicellular anatomical structure
  union of: cell
domain: Class
  union of: cell
  union of: UBERON_0010000
range: Class
  union of: multicellular anatomical structure
  union of: cell
range: Class
  union of: cell
  union of: UBERON_0010000
has curation status: IAO_0000125
textual definition: Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: https://orcid.org/0000-0002-7073-9172
definition source: FBbt
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
is direct form of: develops from
database_cross_reference: RO:0002207
has_exact_synonym: has developmental precursor
has_obo_namespace: uberon
id: directly_develops_from
shorthand: directly_develops_from
comment: TODO - add child relations from DOS
label: directly_develops_from

directly develops into
type: ObjectProperty
sub property of: develops into
has curation status: IAO_0000125
textual definition: inverse of directly develops from
alternative term: developmental precursor of
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
in subset: RO_0002259

has_component
type: ObjectProperty
sub property of: causally upstream of
inverse of: regulated by
type: TransitiveProperty
domain: process
range: process
property chain axiom: has effector activity
property chain axiom: ends with
property chain axiom: directly regulates
has curation status: IAO_0000125
textual definition: p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q.
textual definition: process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.
editor note: We use 'regulates' here to specifically imply control. However, many colloquial usages of the term correctly correspond to the weaker relation of 'causally upstream of or within' (aka influences). Consider relabeling to make things more explicit
definition editor: https://orcid.org/0000-0001-7476-6306
definition editor: https://orcid.org/0000-0002-3837-8864
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
definition editor: David Hill
definition editor: Tanya Berardini
definition source: causal-relations
definition source: GO
curator note: Regulation precludes parthood; the regulatory process may not be within the regulated process.
imported from: cl.owl
imported from: envo.owl
imported from: go.owl
imported from: hp.owl
imported from: mondo.owl
OBO foundry unique label: regulates (processual)
elucidation: false
database_cross_reference: RO:0002211
has_obo_namespace: external
id: regulates
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: regulates
label: regulates
label: regulates (processual)

negatively regulates
type: ObjectProperty
sub property of: has_component
sub property of: causally upstream of, negative effect
inverse of: negatively regulated by
property chain axiom: ends with
textual definition: Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
textual definition: p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q.
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: causal-relations
imported from: cl.owl
imported from: go.owl
imported from: mondo.owl
OBO foundry unique label: negatively regulates (process to process)
is negative form of: has_component
database_cross_reference: RO:0002212
has_obo_namespace: external
id: negatively_regulates
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: negatively_regulates

positively regulates
type: ObjectProperty
sub property of: has_component
sub property of: causally upstream of, positive effect
inverse of: positively regulated by
type: TransitiveProperty
property chain axiom: negatively regulates
property chain axiom: ends with
textual definition: Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
textual definition: p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q.
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: causal-relations
imported from: cl.owl
imported from: go.owl
imported from: mondo.owl
OBO foundry unique label: positively regulates (process to process)
RO_0004049: has_component
database_cross_reference: RO:0002213
has_obo_namespace: external
id: positively_regulates
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: positively_regulates

capable of
type: ObjectProperty
sub property of: capable of part of
sub property of: functionally related to
domain: independent continuant
range: process
example of usage: mechanosensory neuron capable of detection of mechanical stimulus involved in sensory perception (GO:0050974)
example of usage: osteoclast SubClassOf 'capable of' some 'bone resorption'
has curation status: IAO_0000125
textual definition: A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
alternative term: has function realized in
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20123131
definition source: http://www.ncbi.nlm.nih.gov/pubmed/21208450
curator note: For compatibility with BFO, this relation has a shortcut definition in which the expression "capable of some P" expands to "bearer_of (some realized_by only P)".
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: pr.owl
expand expression to: RO_0000053 some (RO_0000054 only ?Y)
database_cross_reference: RO:0002215
has_obo_namespace: external
has_obo_namespace: protein
has_obo_namespace: uberon
id: capable_of
in subset: ro-eco
is transitive: false
shorthand: capable_of
label: capable_of

capable of part of
type: ObjectProperty
sub property of: functionally related to
sub property of: causal agent in
property chain axiom: capable of
property chain axiom: part of
has curation status: IAO_0000125
textual definition: c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
alternative term: has function in
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
expand expression to: RO_0000053 some (RO_0000054 only (BFO_0000050 some ?Y))
database_cross_reference: RO:0002216
has_obo_namespace: external
has_obo_namespace: uberon
id: capable_of_part_of
shorthand: capable_of_part_of

has active participant
type: ObjectProperty
sub property of: has participant
example of usage: 'heart development' has active participant some Shh protein
has curation status: IAO_0000125
textual definition: x has participant y if and only if x realizes some active role that inheres in y
editor note: This may be obsoleted and replaced by the original 'has agent' relation
definition editor: Chris Mungall
alternative term: has agent
imported from: envo.owl
imported from: omrse.owl
in subset: ro-eco

surrounded by
type: ObjectProperty
sub property of: adjacent to
inverse of: surrounds
has curation status: IAO_0000125
textual definition: x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x
textual definition: x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: RO_0001901
database_cross_reference: RO:0002219
has_obo_namespace: uberon
id: surrounded_by
shorthand: surrounded_by
label: surrounded_by

adjacent to
type: ObjectProperty
sub property of: spatially disjoint from
type: FunctionalProperty
type: SymmetricProperty
domain: independent continuant
range: independent continuant
example of usage: A caterpillar walking on the surface of a leaf is adjacent_to the leaf, if one of the caterpillar appendages is touching the leaf. In contrast, a butterfly flying close to a flower is not considered adjacent, unless there are any touching parts.
example of usage: The epidermis layer of a vertebrate is adjacent to the dermis.
example of usage: The plasma membrane of a cell is adjacent to the cytoplasm, and also to the cell lumen which the cytoplasm occupies.
example of usage: The skin of the forelimb is adjacent to the skin of the torso if these are considered anatomical subdivisions with a defined border. Otherwise a relation such as continuous_with would be used.
has curation status: IAO_0000125
textual definition: x adjacent to y if and only if x and y share a boundary.
textual definition: x adjacent_to y iff: x and y share a boundary
editor note: This relation acts as a join point with BSPO
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: RO_0001901
database_cross_reference: RO:0002220
has_obo_namespace: external
has_obo_namespace: uberon
id: adjacent_to
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: adjacent_to
label: adjacent_to

surrounds
type: ObjectProperty
sub property of: adjacent to
has curation status: IAO_0000125
textual definition: inverse of surrounded by
textual definition: inverse of surrounded_by
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: RO_0001901
database_cross_reference: RO:0002221
has_obo_namespace: uberon
id: surrounds
in subset: RO_0002259
shorthand: surrounds

temporally related to
type: ObjectProperty
domain: occurrent
range: occurrent
has curation status: IAO_0000125
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
definition source: Allen's interval algebra
curator note: Do not use this relation directly. It is ended as a grouping for relations between occurrents involving the relative timing of their starts and ends.
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
Source: https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit
source: https://docs.google.com/document/d/1kBv1ep_9g3sTR-SD3jqzFqhuwo9TPNF-l-9fUDbO6rM/edit
in subset: ro-eco
comment: A relation that holds between two occurrents. This is a grouping relation that collects together all the Allen relations.

starts
type: ObjectProperty
sub property of: part of
sub property of: temporally related to
inverse of: starts with
has curation status: IAO_0000125
textual definition: Relation between occurrents, shares a start boundary with.
textual definition: inverse of starts with
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
definition source: Allen
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002223
has_obo_namespace: uberon
id: starts
in subset: ro-eco
shorthand: starts

starts with
type: ObjectProperty
sub property of: has part
sub property of: temporally related to
type: TransitiveProperty
example of usage: Every insulin receptor signaling pathway starts with the binding of a ligand to the insulin receptor
has curation status: IAO_0000125
textual definition: x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
alternative term: started by
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: RO:0002224
has_obo_namespace: external
has_obo_namespace: uberon
id: starts_with
in subset: ro-eco
shorthand: starts_with

develops from part of
type: ObjectProperty
sub property of: develops from
property chain axiom: directly develops from
property chain axiom: part of
has curation status: IAO_0000125
textual definition: x develops from part of y if and only if there exists some z such that x develops from z and z is part of y
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: RO:0002225
has_obo_namespace: uberon
id: develops_from_part_of
shorthand: develops_from_part_of
label: develops_from_part_of

ends
type: ObjectProperty
sub property of: part of
sub property of: temporally related to
inverse of: ends with
has curation status: IAO_0000125
textual definition: Relation between occurrents, shares an end boundary with.
textual definition: inverse of ends with
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002229
has_exact_synonym: finishes
has_obo_namespace: uberon
id: ends
in subset: ro-eco
shorthand: ends

ends with
type: ObjectProperty
sub property of: has part
sub property of: temporally related to
type: TransitiveProperty
has curation status: IAO_0000125
textual definition: x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
alternative term: finished by
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: RO:0002230
has_obo_namespace: external
has_obo_namespace: uberon
id: ends_with
in subset: ro-eco
shorthand: ends_with

has start location
type: ObjectProperty
sub property of: has part that occurs in
domain: process
range: independent continuant
property chain axiom: starts with
property chain axiom: occurs in
has curation status: IAO_0000125
textual definition: x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y
definition editor: https://orcid.org/0000-0002-6601-2165
alternative term: starts with process that occurs in
imported from: cl.owl
database_cross_reference: RO:0002231
has_obo_namespace: external
id: has_start_location
in subset: ro-eco
shorthand: has_start_location

has end location
type: ObjectProperty
sub property of: has part that occurs in
domain: process
range: independent continuant
property chain axiom: ends with
property chain axiom: occurs in
has curation status: IAO_0000125
textual definition: x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y
definition editor: https://orcid.org/0000-0002-6601-2165
alternative term: ends with process that occurs in
imported from: cl.owl
database_cross_reference: RO:0002232
has_obo_namespace: external
id: has_end_location
in subset: ro-eco
shorthand: has_end_location

has input
type: ObjectProperty
sub property of: has participant
inverse of: input of
domain: process
range: material entity
property chain axiom: starts with
has curation status: IAO_0000125
textual definition: p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p.
textual definition: p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
alternative term: consumes
imported from: cl.owl
imported from: envo.owl
imported from: mondo.owl
imported from: ro.owl
database_cross_reference: RO:0002233
has_obo_namespace: external
id: has_input
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
in subset: ro-eco
shorthand: has_input

has output
type: ObjectProperty
sub property of: has participant
inverse of: output of
property chain axiom: ends with
has curation status: IAO_0000125
textual definition: p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p.
textual definition: p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
alternative term: produces
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: ro.owl
database_cross_reference: RO:0002234
has_obo_namespace: external
id: has_output
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
in subset: ro-eco
shorthand: has_output

related via exposure to
type: ObjectProperty
sub property of: causally related to
domain: RO_0002310
textual definition: Any relationship between an exposure event or process and any other entity.
imported from: mondo.owl

connecting branch of
type: ObjectProperty
sub property of: connected to
sub property of: in branching relationship with
inverse of: has connecting branch
example of usage: In the tree T depicted in https://oborel.github.io/obo-relations/branching_part_of.png, B1 is connecting branch of S, and B1-1 as a connecting branch of B1.
textual definition: b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t.
imported from: cl.owl
imported from: hp.owl
RO_0004036: part of
database_cross_reference: RO:0002252
has_obo_namespace: uberon
id: connecting_branch_of
shorthand: connecting_branch_of

has connecting branch
type: ObjectProperty
sub property of: in branching relationship with
textual definition: inverse of connecting branch of
imported from: cl.owl
imported from: hp.owl
RO_0004036: has part
in subset: RO_0002259

has developmental contribution from
type: ObjectProperty
sub property of: developmentally preceded by
sub property of: determined by
inverse of: developmentally_contributes_to
type: TransitiveProperty
domain: anatomical entity
domain: UBERON_0001062
range: anatomical entity
range: UBERON_0001062
property chain axiom: has part
property chain axiom: develops from
example of usage: Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]
has curation status: IAO_0000125
textual definition: x has developmental contribution from y iff x has some part z such that z develops from y
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002254
has_obo_namespace: uberon
id: has_developmental_contribution_from
shorthand: has_developmental_contribution_from

developmentally_contributes_to
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to developmentally contribute to
property chain axiom: develops into
property chain axiom: part of
has curation status: IAO_0000125
textual definition: inverse of has developmental contribution from
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
in subset: RO_0002259
label: developmentally contributes to

developmentally induced by
type: ObjectProperty
sub property of: developmentally preceded by
inverse of: developmentally induces
domain: connected anatomical structure
domain: UBERON_0000465
range: connected anatomical structure
range: UBERON_0000465
has curation status: IAO_0000125
textual definition: t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T.
textual definition: t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor anatomical structure type T to T', where T' develops_from T
textual definition: t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T
definition editor: https://orcid.org/0000-0001-9114-8737
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: https://orcid.org/0000-0002-7073-9172
alternative term: induced by
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20064205
definition source: Developmental Biology, Gilbert, 8th edition, figure 6.5(F)
definition source: GO:0001759
curator note: We place this under 'developmentally preceded by'. This placement should be examined in the context of reciprocal inductions[cjm]
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002256
has_obo_namespace: uberon
id: developmentally_induced_by
shorthand: developmentally_induced_by
comment: sources for developmentally_induced_by relationships in Uberon: Developmental Biology, Gilbert, 8th edition, figure 6.5(F)
label: developmentally_induced_by

developmentally induces
type: ObjectProperty
sub property of: developmentally succeeded by
sub property of: has potential to developmentally induce
has curation status: IAO_0000125
textual definition: Inverse of developmentally induced by
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl

developmentally preceded by
type: ObjectProperty
sub property of: developmentally related to
inverse of: developmentally succeeded by
domain: continuant
range: continuant
has curation status: IAO_0000125
textual definition: Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p
editor note: false
definition editor: https://orcid.org/0000-0002-6601-2165
curator note: In general you should not use this relation to make assertions - use one of the more specific relations below this one
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002258
has_obo_namespace: uberon
id: developmentally_preceded_by
shorthand: developmentally_preceded_by
comment: This relation groups together various other developmental relations. It is fairly generic, encompassing induction, developmental contribution and direct and transitive develops from

developmentally replaces
type: ObjectProperty
sub property of: developmentally preceded by
has curation status: IAO_0000125
textual definition: x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else
editor note: This relation is intended for cases such as when we have a bone element replacing its cartilage element precursor. Currently most AOs represent this using 'develops from'. We need to decide whether 'develops from' will be generic and encompass replacement, or whether we need a new name for a generic relation that encompasses replacement and development-via-cell-lineage
definition editor: https://orcid.org/0000-0002-6601-2165
alternative term: replaces
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002285
has_obo_namespace: uberon
id: developmentally_replaces
shorthand: developmentally_replaces
label: developmentally_replaces

developmentally succeeded by
type: ObjectProperty
sub property of: has developmental potential involving
has curation status: IAO_0000125
textual definition: Inverse of developmentally preceded by
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl

expresses
type: ObjectProperty
sub property of: genomically related to
has curation status: IAO_0000125
textual definition: y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process.
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl

results in developmental progression of
type: ObjectProperty
sub property of: developmentally related to
domain: GO_0008150
range: connected anatomical structure
range: UBERON_0001062
has curation status: IAO_0000125
textual definition: p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss).
textual definition: p results in the developmental progression of s iff p is a developmental process and s is an anatomical structure and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss).
editor note: This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint.
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: RO:0002295
has_obo_namespace: external
id: results_in_developmental_progression_of
shorthand: results_in_developmental_progression_of

results in development of
type: ObjectProperty
sub property of: results in developmental progression of
sub property of: results in changes to anatomical or cellular structure
example of usage: every flower development (GO:0009908) results in development of some flower (PO:0009046)
has curation status: IAO_0000125
textual definition: p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state.
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: http://www.geneontology.org/GO.doc.development.shtml
imported from: cl.owl
database_cross_reference: RO:0002296
has_obo_namespace: external
id: results_in_development_of
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: results_in_development_of

results in formation of
type: ObjectProperty
sub property of: has output
sub property of: results in developmental progression of
inverse of: formed as result of
example of usage: an annotation of gene X to anatomical structure formation with results_in_formation_of UBERON:0000007 (pituitary gland) means that at the beginning of the process a pituitary gland does not exist and at the end of the process a pituitary gland exists.
example of usage: every "endocardial cushion formation" (GO:0003272) results_in_formation_of some "endocardial cushion" (UBERON:0002062)
has curation status: IAO_0000125
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: GOC:mtg_berkeley_2013
imported from: cl.owl
database_cross_reference: RO:0002297
has_obo_namespace: external
id: results_in_formation_of
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: results_in_formation_of

results in morphogenesis of
type: ObjectProperty
sub property of: results in developmental progression of
sub property of: results in changes to anatomical or cellular structure
example of usage: an annotation of gene X to cell morphogenesis with results_in_morphogenesis_of CL:0000540 (neuron) means that at the end of the process an input neuron has attained its shape.
example of usage: tongue morphogenesis (GO:0043587) results in morphogenesis of tongue (UBERON:0001723)
has curation status: IAO_0000125
textual definition: The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state.
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: GOC:mtg_berkeley_2013
imported from: cl.owl
database_cross_reference: RO:0002298
has_obo_namespace: external
id: results_in_morphogenesis_of
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: results_in_morphogenesis_of

causally upstream of, positive effect
type: ObjectProperty
sub property of: causally upstream of
sub property of: causally upstream of or within, positive effect
textual definition: p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q.
imported from: cl.owl
imported from: mondo.owl
RO_0004049: causally upstream of
creator: https://orcid.org/0000-0002-6601-2165
database_cross_reference: RO:0002304
has_obo_namespace: external
id: causally_upstream_of,_positive_effect
in subset: valid for go annotation extension
in subset: valid for gocam
shorthand: causally_upstream_of,_positive_effect
comment: holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y

causally upstream of, negative effect
type: ObjectProperty
sub property of: causally upstream of
sub property of: causally upstream of or within, negative effect
textual definition: p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q.
imported from: cl.owl
imported from: mondo.owl
is negative form of: causally upstream of
creator: https://orcid.org/0000-0002-6601-2165
database_cross_reference: RO:0002305
has_obo_namespace: external
id: causally_upstream_of,_negative_effect
in subset: valid for go annotation extension
in subset: valid for gocam
shorthand: causally_upstream_of,_negative_effect

has exposure stimulus
type: ObjectProperty
sub property of: related via exposure to
textual definition: A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event.
imported from: mondo.owl

inheres in part of
type: ObjectProperty
sub property of: depends on
property chain axiom: inheres in
property chain axiom: part of
textual definition: q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w.
textual definition: q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w.
editor note: Because part_of is transitive, inheres in is a sub-relation of inheres in part of
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/20064205
imported from: envo.owl
imported from: hp.owl
imported from: ro.owl
imported from: vo.owl
temporal interpretation: RO_0001901
database_cross_reference: RO:0002314
id: inheres_in_part_of
shorthand: inheres_in_part_of
label: characteristic of part of

results in acquisition of features of
type: ObjectProperty
sub property of: results in developmental progression of
sub property of: results in changes to anatomical or cellular structure
range: UBERON_0000061
example of usage: an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast.
textual definition: The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: GOC:mtg_berkeley_2013
imported from: cl.owl
database_cross_reference: RO:0002315
has_obo_namespace: external
id: results_in_acquisition_of_features_of
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: results_in_acquisition_of_features_of

evolutionarily related to
type: ObjectProperty
textual definition: A relationship that holds via some environmental process
definition editor: https://orcid.org/0000-0002-6601-2165
curator note: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the process of evolution.
imported from: cl.owl
imported from: mondo.owl
imported from: ro.owl

ecologically related to
type: ObjectProperty
textual definition: A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297)
imported from: mondo.owl

mereotopologically related to
type: ObjectProperty
textual definition: A mereological relationship or a topological relationship
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
curator note: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving parthood or connectivity relationships
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
temporal interpretation: RO_0001901

developmentally related to
type: ObjectProperty
textual definition: A relationship that holds between entities participating in some developmental process (GO:0032502)
definition editor: https://orcid.org/0000-0002-6601-2165
curator note: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving organismal development
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl

enables
type: ObjectProperty
sub property of: capable of
inverse of: enabled by
example of usage: a particular instances of akt-2 enables some instance of protein kinase activity
definition editor: Chris Mungall
alternative term: catalyzes
alternative term: executes
alternative term: has
alternative term: is catalyzing
alternative term: is executing
curator note: This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.
curator note: This relation is currently used experimentally by the Gene Ontology Consortium. It may not be stable and may be obsoleted at some future time.
imported from: envo.owl

functionally related to
type: ObjectProperty
textual definition: A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
curator note: This is a grouping relation that collects relations used for the purpose of connecting structure and function
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: ro.owl
database_cross_reference: RO:0002328
has_obo_namespace: uberon
id: functionally_related_to
shorthand: functionally_related_to

genomically related to
type: ObjectProperty
domain: continuant
range: continuant
textual definition: holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts.
definition editor: https://orcid.org/0000-0002-6601-2165
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving the genome of an organism
imported from: cl.owl
imported from: pr.owl

regulates levels of
type: ObjectProperty
sub property of: functionally related to
domain: process
range: material entity
example of usage: every cellular sphingolipid homeostasis process regulates_level_of some sphingolipid
textual definition: p regulates levels of c if p regulates some amount (PATO:0000070) of c
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: causal-relations
imported from: cl.owl
OBO foundry unique label: regulates levels of (process to entity)
database_cross_reference: RO:0002332
has_obo_namespace: external
id: regulates_levels_of
shorthand: regulates_levels_of

enabled by
type: ObjectProperty
sub property of: functionally related to
sub property of:
  inverse of: capable of
textual definition: inverse of enables
definition editor: Chris Mungall
imported from: envo.owl

regulated by
type: ObjectProperty
sub property of: causally downstream of or within
type: TransitiveProperty
domain: process
range: process
textual definition: inverse of regulates
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
OBO foundry unique label: regulated by (processual)
database_cross_reference: RO:0002334
has_obo_namespace: external
id: regulated_by
in subset: RO_0002259
shorthand: regulated_by

negatively regulated by
type: ObjectProperty
sub property of: regulated by
textual definition: inverse of negatively regulates
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: RO:0002335
has_obo_namespace: external
id: negatively_regulated_by
in subset: RO_0002259
shorthand: negatively_regulated_by

positively regulated by
type: ObjectProperty
sub property of: regulated by
textual definition: inverse of positively regulates
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: RO:0002336
has_obo_namespace: external
id: positively_regulated_by
in subset: RO_0002259
shorthand: positively_regulated_by

related via localization to
type: ObjectProperty
domain: process
range: continuant
textual definition: A relationship that holds via some process of localization
definition editor: https://orcid.org/0000-0002-6601-2165
curator note: Do not use this relation directly. It is a grouping relation.
imported from: cl.owl

has target start location
type: ObjectProperty
sub property of: results in transport to from or in
property chain axiom: part of
textual definition: This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination.
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
database_cross_reference: RO:0002338
has_obo_namespace: external
id: has_target_start_location
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: has_target_start_location

has target end location
type: ObjectProperty
sub property of: results in transport to from or in
property chain axiom: part of
textual definition: This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l.
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
database_cross_reference: RO:0002339
has_obo_namespace: external
id: has_target_end_location
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: has_target_end_location

results in transport along
type: ObjectProperty
sub property of: related via localization to
textual definition: Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
database_cross_reference: RO:0002341
has_obo_namespace: external
id: results_in_transport_along
shorthand: results_in_transport_along

results in transport across
type: ObjectProperty
sub property of: occurs across
sub property of: results in transport to from or in
textual definition: Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m.
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
database_cross_reference: RO:0002342
has_obo_namespace: external
id: results_in_transport_across
in subset: valid for go ontology
shorthand: results_in_transport_across

results in transport to from or in
type: ObjectProperty
sub property of: related via localization to
example of usage: 'mitochondrial transport' results_in_transport_to_from_or_in some mitochondrion (GO:0005739)
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
database_cross_reference: RO:0002344
has_obo_namespace: external
id: results_in_transport_to_from_or_in
shorthand: results_in_transport_to_from_or_in

member of
type: ObjectProperty
sub property of: part of
inverse of: has member
example of usage: An organism that is a member of a population of organisms
textual definition: is member of is a mereological relation between a item and a collection.
alternative term: is member of
alternative term: member part of
definition source: SIO
imported from: omrse.owl
temporal interpretation: RO_0001901

has member
type: ObjectProperty
sub property of: has part
type: IrreflexiveProperty
textual definition: has member is a mereological relation between a collection and an item.
definition source: SIO
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: omrse.owl
imported from: ro.owl
imported from: uberon.owl
temporal interpretation: RO_0001901
database_cross_reference: RO:0002351
has_obo_namespace: uberon
id: has_member
shorthand: has_member

input of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
textual definition: inverse of has input
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
imported from: cl.owl
imported from: envo.owl
imported from: mondo.owl
database_cross_reference: RO:0002352
has_obo_namespace: uberon
id: input_of
in subset: RO_0002259
in subset: ro-eco
shorthand: input_of

output of
type: ObjectProperty
sub property of: participates in
sub property of: functionally related to
textual definition: inverse of has output
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: pr.owl
imported from: ro.owl
database_cross_reference: RO:0002353
has_obo_namespace: external
has_obo_namespace: protein
has_obo_namespace: uberon
id: output_of
in subset: RO_0002259
in subset: ro-eco
is transitive: false
shorthand: output_of
label: output_of

formed as result of
type: ObjectProperty
sub property of: output of
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
imported from: cl.owl
imported from: envo.owl

attached to
type: ObjectProperty
sub property of: connected to
sub property of: connects
sub property of: attached to part of
type: SymmetricProperty
textual definition: a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: mondo.owl
OBO foundry unique label: attached to (anatomical structure to anatomical structure)
database_cross_reference: RO:0002371
has_obo_namespace: uberon
id: attaches_to
in subset: ro-eco
shorthand: attaches_to
label: attaches_to

in branching relationship with
type: ObjectProperty
sub property of: part of
sub property of: mereotopologically related to
domain: material entity
range: material entity
has curation status: IAO_0000428
textual definition: A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network.
definition editor: https://orcid.org/0000-0002-6601-2165
curator note: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving branching relationships
curator note: This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (plant branches and roots, leaf veins, animal veins, arteries, nerves)
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
RO_0004036: part of

tributary of
type: ObjectProperty
sub property of: connected to
sub property of: in branching relationship with
example of usage: Deschutes River tributary_of Columbia River
example of usage: inferior epigastric vein tributary_of external iliac vein
has curation status: IAO_0000428
textual definition: x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein.
definition editor: https://orcid.org/0000-0002-6601-2165
alternative term: drains into
alternative term: drains to
alternative term: tributary channel of
definition source: http://en.wikipedia.org/wiki/Tributary
definition source: http://www.medindia.net/glossary/venous_tributary.htm
curator note: This relation can be used for geographic features (e.g. rivers) as well as anatomical structures (veins, arteries)
imported from: cl.owl
database_cross_reference: RO:0002376
has_obo_namespace: uberon
id: tributary_of
in subset: ro-eco
shorthand: tributary_of

branching part of
type: ObjectProperty
sub property of: part of
sub property of: in branching relationship with
inverse of: has branching part
range: Restriction
  on property: bearer of
  some values from: PATO_0000402
example of usage: In the tree T depicted in https://oborel.github.io/obo-relations/branching_part_of.png, B1 is a (direct) branching part of T. B1-1, B1-2, and B1-3 are also branching parts of T, but these are considered indirect branching parts as they do not directly connect to the main stem S
textual definition: x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002380
has_obo_namespace: uberon
id: branching_part_of
in subset: ro-eco
shorthand: branching_part_of
label: branching_part_of

has developmental potential involving
type: ObjectProperty
sub property of: developmentally related to
domain: anatomical entity
domain: UBERON_0001062
range: anatomical entity
range: UBERON_0001062
has curation status: IAO_0000428
textual definition: x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl

has potential to developmentally contribute to
type: ObjectProperty
sub property of: has developmental potential involving
has curation status: IAO_0000428
textual definition: x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002385
has_obo_namespace: uberon
id: has_potential_to_developmentally_contribute_to
shorthand: has_potential_to_developmentally_contribute_to

has potential to developmentally induce
type: ObjectProperty
sub property of: has developmental potential involving
has curation status: IAO_0000428
textual definition: x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl

has potential to develop into
type: ObjectProperty
sub property of: has developmental potential involving
has curation status: IAO_0000428
textual definition: x has the potential to develop into y iff x develops into y or if x is capable of developing into y
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002387
has_obo_namespace: uberon
id: has_potential_to_develop_into
shorthand: has_potential_to_develop_into

has potential to directly develop into
type: ObjectProperty
sub property of: has potential to develop into
has curation status: IAO_0000428
textual definition: x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl

causally related to
type: ObjectProperty
sub property of: related via dependence to
has curation status: IAO_0000428
textual definition: This relation groups causal relations between material entities and causal relations between processes
textual definition: relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause.
editor note: This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yiel…
editor note: This branch of the ontology deals with causal relations between entities. It is divided into two branches: causal relations between occurrents/processes, and causal relations between material entities. We take an 'activity flow-centric approach', with the former as primary, and define causal relations between material entities in terms of causal relations between occurrents. To define causal relations in an activity-flow type network, we make use of 3 primitives: * Temporal: how do the intervals of the two occurrents relate? * Is the causal relation regulatory? * Is the influence positive or negative? The first of these can be formalized in terms of the Allen Interval Algebra. Informally, the 3 bins we care about are 'direct', 'indirect' or overlapping. Note that all causal relations should be classified under a RO temporal relation (see the branch under 'temporally related to'). Note that all causal relations are temporal, but not all temporal relations are causal. Two occurrents can be related in time without being causally connected. We take causal influence to be primitive, elucidated as being such that has the upstream changed, some qualities of the donwstream would necessarily be modified. For the second, we consider a relationship to be regulatory if the system in which the activities occur is capable of altering the relationship to achieve some objective. This could include changing the rate of production of a molecule. For the third, we consider the effect of the upstream process on the output(s) of the downstream process. If the level of output is increased, or the rate of production of the output is increased, then the direction is increased. Direction can be positive, negative or neutral or capable of either direction. Two positives in succession yield a positive, two negatives in succession yield a positive, otherwise the default assumption is that the net effect is canceled and the influence is neutral. Each of these 3 primitives can be composed to yie…
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl

causally upstream of
type: ObjectProperty
sub property of: precedes
sub property of: causally upstream of or within
type: TransitiveProperty
has curation status: IAO_0000428
textual definition: p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain
textual definition: p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002411
has_obo_namespace: external
id: causally_upstream_of
in subset: valid for go annotation extension
in subset: valid for gocam
shorthand: causally_upstream_of

immediately causally upstream of
type: ObjectProperty
sub property of: immediately precedes
sub property of: causally upstream of
has curation status: IAO_0000428
textual definition: p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q.
textual definition: p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
is direct form of: causally upstream of
database_cross_reference: RO:0002412
has_obo_namespace: external
id: immediately_causally_upstream_of
shorthand: immediately_causally_upstream_of

causally upstream of or within
type: ObjectProperty
sub property of: causal relation between processes
inverse of: causally downstream of or within
type: TransitiveProperty
textual definition: p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.
textual definition: p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q.
editor note: We would like to make this disjoint with 'preceded by', but this is prohibited in OWL2
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
alternative term: influences (processual)
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002418
has_obo_namespace: external
has_related_synonym: affects
id: causally_upstream_of_or_within
shorthand: causally_upstream_of_or_within

causally downstream of or within
type: ObjectProperty
sub property of: causal relation between processes
type: TransitiveProperty
textual definition: inverse of causally upstream of or within
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
definition source: causal-relations
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002427
has_obo_namespace: external
id: causally_downstream_of_or_within
in subset: RO_0002259
shorthand: causally_downstream_of_or_within

contributes to morphology of
type: ObjectProperty
sub property of: overlaps
textual definition: p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm.
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002433
has_obo_namespace: uberon
id: contributes_to_morphology_of
shorthand: contributes_to_morphology_of

transmitted by
type: ObjectProperty
sub property of: ecologically related to
textual definition: A relationship that holds between a disease and organism
imported from: mondo.owl
database_cross_reference: RO:0002451
id: transmitted_by
shorthand: transmitted_by

composed primarily of
type: ObjectProperty
sub property of: has part
domain: material entity
range: material entity
example of usage: 'otolith organ' SubClassOf 'composed primarily of' some 'calcium carbonate'
textual definition: x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y.
textual definition: x composed_primarily_of y iff: more than half of the mass of x is made from parts of y
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/22293552
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
temporal interpretation: RO_0001901
has_alternative_id: UBREL:0000002
database_cross_reference: RO:0002473
has_obo_namespace: uberon
id: composed_primarily_of
in subset: ro-eco
shorthand: composed_primarily_of

has part that occurs in
type: ObjectProperty
domain: occurrent
range: independent continuant
property chain axiom: has part
property chain axiom: occurs in
textual definition: p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c.
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
in subset: ro-eco

relation between physical entity and a process or stage
type: ObjectProperty
domain: independent continuant
domain: Class
  union of: material anatomical entity
  union of: immaterial anatomical entity
range: occurrent
definition editor: https://orcid.org/0000-0002-6601-2165
curator note: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, typically connecting an anatomical entity to a biological process or developmental stage.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl

existence starts during
type: ObjectProperty
sub property of: existence overlaps
sub property of: existence starts during or after
property chain axiom: part of
textual definition: Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s.
textual definition: x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y).
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: BFO:0000068
database_cross_reference: RO:0002488
has_exact_synonym: begins_to_exist_during
has_obo_namespace: uberon
id: existence_starts_during
shorthand: existence_starts_during

existence starts with
type: ObjectProperty
sub property of: existence starts during
textual definition: Relation between continuant and occurrent, such that c comes into existence at the start of p.
textual definition: x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y).
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002489
has_obo_namespace: uberon
id: existence_starts_with
shorthand: existence_starts_with

existence overlaps
type: ObjectProperty
sub property of: relation between physical entity and a process or stage
textual definition: x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.

existence starts and ends during
type: ObjectProperty
sub property of: existence starts during
sub property of: existence ends during
textual definition: x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002491
has_exact_synonym: exists during
has_obo_namespace: uberon
id: existence_starts_and_ends_during
shorthand: existence_starts_and_ends_during
comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.

existence ends during
type: ObjectProperty
sub property of: existence overlaps
sub property of: existence ends during or before
property chain axiom: part of
textual definition: Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely.
textual definition: x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y).
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
has_alternative_id: BFO:0000069
database_cross_reference: RO:0002492
has_exact_synonym: ceases_to_exist_during
has_obo_namespace: uberon
id: existence_ends_during
shorthand: existence_ends_during
comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.

existence ends with
type: ObjectProperty
sub property of: existence ends during
textual definition: Relation between continuant and occurrent, such that c ceases to exist at the end of p.
textual definition: x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y).
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002493
has_obo_namespace: uberon
id: existence_ends_with
shorthand: existence_ends_with
comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.

transformation of
type: ObjectProperty
sub property of: develops from
type: TransitiveProperty
textual definition: x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002494
has_exact_synonym: transforms from
has_obo_namespace: uberon
id: transformation_of
shorthand: transformation_of

immediate transformation of
type: ObjectProperty
sub property of: directly develops from
sub property of: transformation of
textual definition: x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
is direct form of: transformation of
database_cross_reference: RO:0002495
has_exact_synonym: direct_transformation_of
has_exact_synonym: immediately transforms from
has_obo_namespace: uberon
id: immediate_transformation_of
shorthand: immediate_transformation_of

existence starts during or after
type: ObjectProperty
sub property of: relation between physical entity and a process or stage
property chain axiom: part of
property chain axiom: developmentally preceded by
property chain axiom: preceded by
property chain axiom: simultaneous with
textual definition: x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y).
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002496
has_obo_namespace: uberon
id: existence_starts_during_or_after
shorthand: existence_starts_during_or_after
comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.

existence ends during or before
type: ObjectProperty
sub property of: relation between physical entity and a process or stage
property chain axiom: part of
property chain axiom: developmentally succeeded by
property chain axiom: precedes
property chain axiom: simultaneous with
textual definition: x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends.
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002497
has_obo_namespace: uberon
id: existence_ends_during_or_before
shorthand: existence_ends_during_or_before
comment: The relations here were created based on work originally by Fabian Neuhaus and David Osumi-Sutherland. The work has not yet been vetted and errors in definitions may have occurred during transcription.

causal agent in
type: ObjectProperty
sub property of: causal relation between material entity and a process
inverse of: has causal agent
textual definition: A relationship between a material entity and a process where the material entity has some causal role that influences the process
definition source: causal-relations
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
label: causal agent in process

causal relation between processes
type: ObjectProperty
sub property of: causally related to
domain: occurrent
range: occurrent
textual definition: p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.
textual definition: p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
definition source: causal-relations
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl

depends on
type: ObjectProperty
definition editor: Chris Mungall
imported from: envo.owl
imported from: hp.owl
imported from: ro.owl
imported from: vo.owl

towards
type: ObjectProperty
sub property of: depends on
textual definition: q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2
imported from: hp.owl
database_cross_reference: RO:0002503
id: towards
shorthand: towards

causal relation between material entities
type: ObjectProperty
sub property of: causally related to
domain: material entity
range: material entity
editor note: The intent is that the process branch of the causal property hierarchy is primary (causal relations hold between occurrents/processes), and that the material branch is defined in terms of the process branch
definition editor: Chris Mungall
definition source: causal-relations
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
imported from: envo.owl

determined by
type: ObjectProperty
sub property of: part of
sub property of: determined by part of
sub property of: causally influenced by
inverse of: determines
type: TransitiveProperty
domain: RO_0002577
range: material entity
property chain axiom: has part
property chain axiom: develops from
example of usage: A coral reef environment is determined by a particular coral reef
textual definition: s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s.
editor note: The label for this relation is probably too general for its restricted use, where the domain is a system. It may be relabeled in future
definition editor: Chris Mungall
definition source: http://www.ncbi.nlm.nih.gov/pubmed/24330602
imported from: envo.owl
imported from: oae.owl
imported from: uberon.owl
OBO foundry unique label: determined by (system to material entity)
creator: Chris Mungall
creator: Pier Buttigieg
database_cross_reference: RO:0002507
has_obo_namespace: uberon
id: has_material_contribution_from
in subset: ro-eco
shorthand: has_material_contribution_from
label: has material contribution from

determines
type: ObjectProperty
sub property of: causally influences
textual definition: inverse of determined by
definition editor: Chris Mungall
imported from: envo.owl
OBO foundry unique label: determines (material entity to system)
in subset: RO_0002259
in subset: ro-eco

determined by part of
type: ObjectProperty
sub property of: overlaps
sub property of: causal relation between material entities
domain: RO_0002577
range: material entity
property chain axiom: determined by
property chain axiom: part of
textual definition: s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w.
definition editor: Chris Mungall
imported from: envo.owl
in subset: ro-eco

has skeleton
type: ObjectProperty
sub property of: has part
inverse of: skeleton of
type: AsymmetricProperty
type: IrreflexiveProperty
domain: connected anatomical structure
domain: UBERON_0000061
domain: UBERON_0000475
range: material anatomical entity
range: UBERON_0000465
range: UBERON_0010912
example of usage: Forelimb SubClassOf has_skeleton some 'Forelimb skeleton'
textual definition: A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision.
textual definition: A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision.
definition editor: https://orcid.org/0000-0002-6601-2165
alternative term: has supporting framework
curator note: The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell).
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002551
has_obo_namespace: uberon
has_related_synonym: has sekeletal support
has_related_synonym: has supporting framework
id: has_skeleton
shorthand: has_skeleton

causally influenced by
type: ObjectProperty
sub property of: causal relation between material entities
inverse of: causally influences
definition editor: Chris Mungall
definition source: causal-relations
imported from: envo.owl
OBO foundry unique label: causally influenced by (material entity to material entity)

results in movement of
type: ObjectProperty
sub property of: results in changes to anatomical or cellular structure
textual definition: Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
database_cross_reference: RO:0002565
has_obo_namespace: external
id: results_in_movement_of
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: results_in_movement_of

causally influences
type: ObjectProperty
sub property of: causal relation between material entities
property chain axiom: enables
property chain axiom: causally upstream of
property chain axiom: has input
property chain axiom: enabled by
textual definition: Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b
definition editor: Chris Mungall
definition source: causal-relations
imported from: envo.owl
OBO foundry unique label: causally influences (material entity to material entity)

biomechanically related to
type: ObjectProperty
sub property of: functionally related to
domain: connected anatomical structure
domain: UBERON_0000061
range: connected anatomical structure
range: UBERON_0000061
textual definition: A relation that holds between elements of a musculoskeletal system or its analogs.
definition editor: https://orcid.org/0000-0002-6601-2165
curator note: Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes.
imported from: cl.owl
imported from: mondo.owl

has branching part
type: ObjectProperty
sub property of: has part
sub property of: in branching relationship with
type: TransitiveProperty
textual definition: inverse of branching part of
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002569
has_obo_namespace: uberon
id: has_branching_part
in subset: RO_0002259
in subset: ro-eco
shorthand: has_branching_part

conduit for
type: ObjectProperty
sub property of: overlaps
domain: material entity
range: material entity
textual definition: x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x.
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: UBERON:cjm
curator note: This relation holds between a thing with a 'conduit' (e.g. a bone foramen) and a 'conduee' (for example, a nerve) such that at the time the relationship holds, the conduee has two ends sticking out either end of the conduit. It should therefore note be used for objects that move through the conduit but whose spatial extent does not span the passage. For example, it would not be used for a mountain that contains a long tunnel through which trains pass. Nor would we use it for a digestive tract and objects such as food that pass through.
imported from: cl.owl
imported from: hp.owl
database_cross_reference: RO:0002570
has_obo_namespace: uberon
id: conduit_for
in subset: ro-eco
shorthand: conduit_for

lumen of
type: ObjectProperty
sub property of: part of
range: material entity
textual definition: x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull.
definition editor: https://orcid.org/0000-0002-6601-2165
definition source: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002571
has_obo_namespace: uberon
id: lumen_of
in subset: ro-eco
shorthand: lumen_of

luminal space of
type: ObjectProperty
sub property of: part of
sub property of: lumen of
domain: immaterial entity
textual definition: s is luminal space of x iff s is lumen_of x and s is an immaterial entity
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002572
has_obo_namespace: uberon
id: luminal_space_of
in subset: ro-eco
shorthand: luminal_space_of

has modifier
type: ObjectProperty
domain: specifically dependent continuant
range: specifically dependent continuant
textual definition: A relation that holds between an attribute or a qualifier and another attribute.
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002180
database_cross_reference: RO:0002573
id: has_modifier
id: qualifier
in subset: ro-eco
shorthand: has_modifier
shorthand: qualifier
comment: placeholder relation to indicate normality/abnormality.

skeleton of
type: ObjectProperty
sub property of: part of
domain: connected anatomical structure
domain: UBERON_0000061
range: connected anatomical structure
range: UBERON_0000061
textual definition: inverse of has skeleton
definition editor: https://orcid.org/0000-0002-6601-2165
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0002576
has_obo_namespace: uberon
id: skeleton_of
in subset: RO_0002259
shorthand: skeleton_of

directly regulates
type: ObjectProperty
sub property of: has_component
sub property of: immediately causally upstream of
textual definition: Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
textual definition: p directly regulates q iff p is immediately causally upstream of q and p regulates q.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
definition source: causal-relations
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
OBO foundry unique label: directly regulates (processual)
is direct form of: has_component
database_cross_reference: RO:0002578
has_obo_namespace: external
id: directly_regulates
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: directly_regulates

results in breakdown of
type: ObjectProperty
sub property of: has input
textual definition: p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p
imported from: cl.owl

results in assembly of
type: ObjectProperty
sub property of: results in formation of
sub property of: results in organization of
imported from: cl.owl
database_cross_reference: RO:0002588
has_obo_namespace: external
id: results_in_assembly_of
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: results_in_assembly_of

results in disassembly of
type: ObjectProperty
sub property of: results in breakdown of
sub property of: results in organization of
imported from: cl.owl
database_cross_reference: RO:0002590
has_obo_namespace: external
id: results_in_disassembly_of
shorthand: results_in_disassembly_of

results in organization of
type: ObjectProperty
sub property of: has participant
sub property of: results in changes to anatomical or cellular structure
textual definition: p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c
imported from: cl.owl
database_cross_reference: RO:0002592
has_obo_namespace: external
id: results_in_organization_of
shorthand: results_in_organization_of

causal relation between material entity and a process
type: ObjectProperty
sub property of: causally related to
domain: material entity
range: process
textual definition: A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.
editor note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
definition editor: https://orcid.org/0000-0002-6601-2165
definition editor: Chris Mungall
definition source: causal-relations
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl

has causal agent
type: ObjectProperty
sub property of: causally related to
textual definition: Inverse of 'causal agent in process'
textual definition: Inverse of 'causal agent in'
definition source: causal-relations
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: RO:0002608
has_obo_namespace: external
id: process_has_causal_agent
shorthand: process_has_causal_agent
label: process has causal agent

related via dependence to
type: ObjectProperty
textual definition: A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes.
curator note: Do not use this relation directly. It is intended as a grouping for a diverse set of relations, all involving cause and effect.
imported from: envo.owl

produces
type: ObjectProperty
inverse of: produced by
domain: material entity
range: material entity
property chain axiom:
  inverse of: occurs in
property chain axiom: has output
has curation status: IAO_0000125
textual definition: a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix.
definition editor: https://orcid.org/0000-0001-9114-8737
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
database_cross_reference: RO:0003000
has_obo_namespace: external
has_obo_namespace: uberon
id: produces
in subset: ro-eco
shorthand: produces
comment: Note that this definition doesn't quite distinguish the output of a transformation process from a production process, which is related to the identity/granularity issue.

produced by
type: ObjectProperty
domain: material entity
range: material entity
has curation status: IAO_0000125
textual definition: a produced_by b iff some process that occurs_in b has_output a.
definition editor: https://orcid.org/0000-0001-9114-8737
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: ro.owl
imported from: uberon.owl
database_cross_reference: RO:0003001
has_obo_namespace: external
has_obo_namespace: uberon
id: produced_by
in subset: ro-eco
shorthand: produced_by
label: produced_by

has primary input or output
type: ObjectProperty
sub property of: has participant
textual definition: p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c.
imported from: cl.owl
created by: https://orcid.org/0000-0002-6601-2165
creation date: 2018-12-13T11:26:17Z
database_cross_reference: RO:0004007
has_obo_namespace: external
id: has_primary_input_or_output
in subset: valid for go ontology
shorthand: has_primary_input_or_output

has primary output
type: ObjectProperty
sub property of: has output
sub property of: has primary input or output
textual definition: p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c.
imported from: cl.owl
created by: https://orcid.org/0000-0002-6601-2165
creation date: 2018-12-13T11:26:32Z
database_cross_reference: RO:0004008
has_obo_namespace: external
id: has_primary_output
in subset: valid for go ontology
shorthand: has_primary_output

has primary input
type: ObjectProperty
sub property of: has input
sub property of: has primary input or output
textual definition: p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c.
imported from: cl.owl
created by: https://orcid.org/0000-0002-6601-2165
creation date: 2018-12-13T11:26:56Z
database_cross_reference: RO:0004009
has_obo_namespace: external
id: has_primary_input
in subset: valid for go ontology
shorthand: has_primary_input

realizable has basis in
type: ObjectProperty
sub property of: causally related to
inverse of: is basis for realizable
imported from: mondo.owl

is basis for realizable
type: ObjectProperty
sub property of: causally related to
imported from: mondo.owl

disease has basis in
type: ObjectProperty
sub property of: realizable has basis in
sub property of: causal relationship with disease as subject
imported from: mondo.owl

disease has basis in dysfunction of
type: ObjectProperty
sub property of: disease has basis in
range: material anatomical entity
textual definition: A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function.
imported from: mondo.owl
database_cross_reference: RO:0004020
id: disease_has_basis_in_dysfunction_of
shorthand: disease_has_basis_in_dysfunction_of

disease caused by disruption of
type: ObjectProperty
sub property of: disease has basis in
sub property of: disease causes disruption of
range: process
property chain axiom: part of
textual definition: A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process.
imported from: mondo.owl
database_cross_reference: RO:0004021
id: disease_has_basis_in_disruption_of
shorthand: disease_has_basis_in_disruption_of
comment: Editor note: TODO property chain: disease_has_location <- dhbido o occurs_in
label: disease has basis in disruption of

disease arises from feature
type: ObjectProperty
sub property of: has phenotype
sub property of: disease has basis in
type: TransitiveProperty
textual definition: A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature.
imported from: mondo.owl
database_cross_reference: RO:0004022
id: disease_arises_from_feature
shorthand: disease_arises_from_feature
label: disease has basis in feature

causal relationship with disease as subject
type: ObjectProperty
sub property of: causally related to
sub property of: disease relationship
imported from: mondo.owl

disease causes disruption of
type: ObjectProperty
sub property of: causal relationship with disease as subject
range: process
property chain axiom: part of
property chain axiom: disease causes dysfunction of
property chain axiom: capable of
textual definition: A relationship between a disease and a process where the disease process disrupts the execution of the process.
imported from: mondo.owl
database_cross_reference: RO:0004024
id: disease_disrupts
shorthand: disease_disrupts
label: disease disrupts

disease causes dysfunction of
type: ObjectProperty
sub property of: causal relationship with disease as subject
range: material anatomical entity
property chain axiom: part of
imported from: mondo.owl
database_cross_reference: RO:0004025
id: disease_causes_dysfunction_of
shorthand: disease_causes_dysfunction_of

disease has location
type: ObjectProperty
sub property of: disease relationship
range: independent continuant
range: Class
  union of: material anatomical entity
  union of: immaterial anatomical entity
property chain axiom: part of
textual definition: A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity.
imported from: mondo.owl
database_cross_reference: RO:0004026
id: disease_has_location
shorthand: disease_has_location

disease has inflammation site
type: ObjectProperty
sub property of: disease has location
range: independent continuant
range: Class
  union of: material anatomical entity
  union of: immaterial anatomical entity
property chain axiom: part of
textual definition: A relationship between a disease and an anatomical entity where the disease is triggered by an inflammatory response to stimuli occurring in the anatomical entity
imported from: mondo.owl
database_cross_reference: RO:0004027
id: disease_has_inflammation_site
shorthand: disease_has_inflammation_site

realized in response to stimulus
type: ObjectProperty
sub property of: causally related to
domain: realizable entity
range: material entity
property chain axiom: realized in response to
property chain axiom: has input
textual definition: A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M.
imported from: mondo.owl
database_cross_reference: RO:0004028
id: realized_in_response_to_stimulus
shorthand: realized_in_response_to_stimulus

disease has feature
type: ObjectProperty
sub property of: disease relationship
property chain axiom: has part
textual definition: A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease.
imported from: mondo.owl
database_cross_reference: RO:0004029
id: disease_has_feature
shorthand: disease_has_feature

disease arises from structure
type: ObjectProperty
sub property of: disease has basis in
range: connected anatomical structure
textual definition: A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure.
imported from: mondo.owl
database_cross_reference: RO:0004030
id: disease_arises_from_structure
shorthand: disease_arises_from_structure

causally upstream of or within, negative effect
type: ObjectProperty
sub property of: causally upstream of or within
imported from: cl.owl
imported from: mondo.owl
is negative form of: causally upstream of or within
created by: https://orcid.org/0000-0002-6601-2165
creation date: 2018-03-13T23:55:05Z

causally upstream of or within, positive effect
type: ObjectProperty
sub property of: causally upstream of or within
imported from: cl.owl
imported from: mondo.owl
RO_0004049: causally upstream of or within
created by: https://orcid.org/0000-0002-6601-2165
creation date: 2018-03-13T23:55:19Z

realized in response to
type: ObjectProperty
sub property of: causally related to
domain: realizable entity
range: process
textual definition: r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r.
imported from: mondo.owl
database_cross_reference: RO:0009501
has_exact_synonym: triggered by process
id: realized_in_response_to
shorthand: realized_in_response_to

acts on population of
type: ObjectProperty
sub property of: has participant
textual definition: p acts on population of c iff c' is a collection, has members of type c, and p has participant c
imported from: cl.owl
created by: https://orcid.org/0000-0003-1813-6857
creation date: 2020-06-08T17:21:33Z
database_cross_reference: RO:0012003
has_obo_namespace: external
id: acts_on_population_of
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: acts_on_population_of

results in fusion of
type: ObjectProperty
sub property of: results in organization of
imported from: cl.owl
created by: https://orcid.org/0000-0003-1813-6857
creation date: 2021-02-26T07:28:29Z
database_cross_reference: RO:0012008
has_obo_namespace: external
id: results_in_fusion_of
in subset: valid for go annotation extension
in subset: valid for go ontology
in subset: valid for gocam
shorthand: results_in_fusion_of

has synaptic IO in region
type: ObjectProperty
sub property of: has synaptic terminal in
property chain axiom: part of
textual definition: A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region.
imported from: cl.owl
created by: https://orcid.org/0000-0002-1373-1705
creation date: 2020-07-17T09:26:52Z
has_exact_synonym: has synaptic input or output in

different in magnitude relative to
type: ObjectProperty
domain: PATO_0000001
range: PATO_0000001
textual definition: q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
imported from: hp.owl

increased in magnitude relative to
type: ObjectProperty
sub property of: different in magnitude relative to
domain: PATO_0000001
range: PATO_0000001
textual definition: q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
imported from: hp.owl
comment: This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'.

decreased in magnitude relative to
type: ObjectProperty
sub property of: different in magnitude relative to
domain: PATO_0000001
range: PATO_0000001
textual definition: q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
imported from: hp.owl
comment: This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'.

has cross section
type: ObjectProperty
textual definition: s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
imported from: cl.owl
imported from: hp.owl
comment: Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round.

reciprocal of
type: ObjectProperty
textual definition: q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.
imported from: hp.owl
comment: There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality.

has high plasma membrane amount
type: ObjectProperty
sub property of: has plasma membrane part
domain: cell
example of usage: 'Ly-76 high positive erythrocyte' equivalent to 'enucleate erythrocyte' and (has_high_plasma_membrane_amount some 'lymphocyte antigen 76 (mouse)')
textual definition: A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1617-8244
contributor: https://orcid.org/0000-0003-1940-6740

has low plasma membrane amount
type: ObjectProperty
sub property of: has plasma membrane part
domain: cell
example of usage: 'DN2b thymocyte' equivalent to 'DN2 thymocyte' and (has_low_plasma_membrane_amount some 'mast/stem cell growth factor receptor')
textual definition: A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1617-8244
contributor: https://orcid.org/0000-0003-1940-6740

disease relationship
type: ObjectProperty
textual definition: This relation groups relations between diseases and any other kind of entity.
imported from: mondo.owl

results in changes to anatomical or cellular structure
type: ObjectProperty
sub property of: has participant
textual definition: p has anatomical participant c iff p has participant c, and c is an anatomical entity
imported from: cl.owl
created by: https://orcid.org/0000-0002-6601-2165
creation date: 2018-09-26T01:08:58Z
database_cross_reference: RO:0040036
has_obo_namespace: external
id: results_in_changes_to_anatomical_or_cellular_structure
shorthand: results_in_changes_to_anatomical_or_cellular_structure

has vaccine allergen
type: ObjectProperty
sub property of: topObjectProperty
domain: VO_0000001
textual definition: a object property that specifies a relation between a vaccine and a vaccine allergen
definition editor: YH
imported from: vo.owl

immunizes host
type: ObjectProperty
domain: VO_0000001
range: OBI_0100026
textual definition: a shortcut relation that equals to: 'processed material' and (is_specified_output_of some 'vaccine preparation') and ('has function' some ('vaccine function' and ('is realized by' only ('vaccine immunization' and (realizes some ('vaccine host role' and (role_of some 'organism')))))))). The domain of this relation is a vaccine. The range of this relation is a organism.
definition editor: YL
definition editor: Yongqun He
alternative term: immunization for host
alternative term: vaccine immunization for host
imported from: vo.owl

immunizes against microbe
type: ObjectProperty
textual definition: a shortcut relation that equals to: processed material and (is_specified_output_of some vaccine preparation) and (has function some (vaccine function and (is realized by only (vaccine immunization and (realizes some ('immunization target role' and (role_of some 'MICROBE')))))))) The domain of this relation is a vaccine. The range of this relation is a microbe (a bacterium, a virus, a fungus, and a parasite)
definition editor: Yongqun He
alternative term: immunization against microbe
alternative term: vaccine immunization against microbe
imported from: vo.owl

has parent hydride
type: ObjectProperty
imported from: hp.owl
imported from: mondo.owl

is conjugate acid of
type: ObjectProperty
inverse of: is conjugate base of
imported from: hp.owl
imported from: mondo.owl

is conjugate base of
type: ObjectProperty
imported from: hp.owl
imported from: mondo.owl

is substituent group from
type: ObjectProperty
imported from: hp.owl
imported from: mondo.owl

has_completed
type: ObjectProperty
imported from: mondo.owl

has_high_plasma_membrane_amount
type: ObjectProperty
sub property of: has plasma membrane part
textual definition: A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617).
imported from: mondo.owl

has_low_plasma_membrane_amount
type: ObjectProperty
sub property of: has plasma membrane part
textual definition: A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617).
imported from: mondo.owl

has_not_completed
type: ObjectProperty
imported from: mondo.owl

lacks_part
type: ObjectProperty
imported from: mondo.owl
expand expression to: http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 ?Y

lacks_plasma_membrane_part
type: ObjectProperty
imported from: mondo.owl
expand expression to: http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)

interacts_with
type: ObjectProperty
imported from: mondo.owl

interacts_with_an_exposure_receptor_via
type: ObjectProperty
imported from: mondo.owl

interacts_with_an_exposure stressor_via
type: ObjectProperty
imported from: mondo.owl

disease causes feature
type: ObjectProperty
imported from: mondo.owl
id: disease_causes_feature

disease_has_basis_in_development_of
type: ObjectProperty
imported from: mondo.owl
id: disease_has_basis_in_development_of

disease has major feature
type: ObjectProperty
sub property of: disease has feature
property chain axiom: has part
imported from: mondo.owl
id: disease_has_major_feature

disease responds to
type: ObjectProperty
imported from: mondo.owl
id: disease_responds_to

disease shares features of
type: ObjectProperty
imported from: mondo.owl
id: disease_shares_features_of

predisposes towards
type: ObjectProperty
imported from: mondo.owl
id: predisposes_towards

different_in_magnitude_relative_to
type: ObjectProperty
domain: PATO_0000001
range: PATO_0000001
textual definition: q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
imported from: mondo.owl

has_cross_section
type: ObjectProperty
textual definition: s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.
imported from: mondo.owl

increased_in_magnitude_relative_to
type: ObjectProperty
sub property of: different_in_magnitude_relative_to
type: TransitiveProperty
domain: PATO_0000001
range: PATO_0000001
textual definition: q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.
imported from: mondo.owl

has_constituent_monomer
type: ObjectProperty
sub property of: has component
textual definition: A relation that holds between a polymer and its constituent monomers. P has_constituent_monomer c if and only if P has_component multiple instances of c and each instance of c is covalently attached to another instance of c.
imported from: cl.owl
imported from: hp.owl
imported from: pr.owl
has_obo_namespace: protein
id: has_constituent_monomer
is transitive: false
comment: The constituent monomers need not be covalently attached in an end-to-end manner; that is, polymers with internal connections (e.g., polyubiquitin) can use this relation, as can circular polymers (e.g., plasmids) and multi-branched polymers (e.g., glycans). This relation, as non-transitive, allows one to indicate the number of instances of c.

has_gene_template
type: ObjectProperty
sub property of: genomically related to
textual definition: See document https://docs.google.com/document/d/15iVMtMyYbQSlvUDgn2XUaDzpwkB0USZI for full definition.
imported from: pr.owl
has_obo_namespace: protein
id: has_gene_template
is transitive: false

lacks_part
type: ObjectProperty
textual definition: A negation of the has_part relation.
imported from: pr.owl
has_obo_namespace: protein
id: lacks_part
is transitive: false

has_part
type: ObjectProperty
textual definition: Inverse of part_of.
imported from: mondo.owl

has_quality
type: ObjectProperty
imported from: mondo.owl

member_of
type: ObjectProperty
sub property of: part_of
type: TransitiveProperty
imported from: mondo.owl

part_of
type: ObjectProperty
type: TransitiveProperty
textual definition: X part_of Y if X is a subregion of Y.
imported from: mondo.owl

anteriorly connected to
type: ObjectProperty
sub property of: posterior_to
sub property of: connected to
sub property of: transitively anteriorly connected to
textual definition: x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y.
imported from: mondo.owl

channel for
type: ObjectProperty
domain: UBERON_0004111
range: UBERON_0000463
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
has_broad_synonym: carries
has_obo_namespace: uberon
id: channel_for

channels_from
type: ObjectProperty
type: TransitiveProperty
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: uberon
id: channels_from

channels_into
type: ObjectProperty
type: TransitiveProperty
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: uberon
id: channels_into

conduit for
type: ObjectProperty
textual definition: x is a conduit for y iff y passes through the lumen of x.
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: conduit_for

distally connected to
type: ObjectProperty
sub property of: proximal_to
sub property of: connected to
sub property of: transitively distally connected to
inverse of: proximally connected to
textual definition: x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y.
imported from: mondo.owl

existence starts and ends during
type: ObjectProperty
sub property of: existence starts during
sub property of: existence ends during
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: existence_starts_and_ends_during

extends_fibers_into
type: ObjectProperty
sub property of: connected to
type: SymmetricProperty
property chain axiom: has soma location
property chain axiom: has synaptic IO in region
textual definition: X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y
imported from: cl.owl
imported from: mondo.owl
has_obo_namespace: uberon
id: extends_fibers_into

filtered through
type: ObjectProperty
textual definition: Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: uberon
id: filtered_through
comment: Relationship between a fluid and a filtration barrier, where the portion of fluid arises as a transformation of another portion of fluid on the other side of the barrier, with larger particles removed

in_central_side_of
type: ObjectProperty
sub property of: part of
textual definition: X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides.
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: in_central_side_of

posteriorly connected to
type: ObjectProperty
sub property of: anterior to
sub property of: connected to
textual definition: x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y.
imported from: mondo.owl

protects
type: ObjectProperty
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: uberon
id: protects

proximally connected to
type: ObjectProperty
sub property of: distal to
sub property of: connected to
sub property of: transitively proximally connected to
textual definition: x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: uberon
id: proximally_connected_to

site_of
type: ObjectProperty
textual definition: c site_of p if c is the bearer of a disposition that is realized by a process that has p as part.
imported from: cl.owl
imported from: hp.owl
has_obo_namespace: uberon
has_related_synonym: capable_of_has_part
id: site_of

subdivision of
type: ObjectProperty
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: uberon.owl
has_obo_namespace: uberon
id: subdivision_of
comment: placeholder relation. X = 'subdivision of A' and subdivision_of some B means that X is the mereological sum of A and B

transitively anteriorly connected to
type: ObjectProperty
type: TransitiveProperty
textual definition: .
imported from: mondo.owl

transitively_connected to
type: ObjectProperty
type: TransitiveProperty
imported from: mondo.owl

transitively distally connected to
type: ObjectProperty
type: TransitiveProperty
textual definition: .
imported from: mondo.owl

transitively proximally connected to
type: ObjectProperty
type: TransitiveProperty
textual definition: .
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: uberon
id: transitively_proximally_connected_to

has_proper_part
type: ObjectProperty
sub property of: topObjectProperty
type: TransitiveProperty
imported from: dron.owl
imported from: http://purl.org/obo/owl/relationship
has_alternative_id: OBO_REL:0000007
has_obo_namespace: relationship

has measurement value
type: DatatypeProperty
sub property of: topDataProperty
type: FunctionalProperty
domain: IAO_0000032
range: double
imported from: iao.owl

has digit number
type: DatatypeProperty
range: integer
example of usage: The data type "last 4 digits of social security number" has digit number of 4.
textual definition: A data property that represents a relation between a data type and a number of integer digits that the data type has.
definition editor: Oliver He

quality measured by year
type: DatatypeProperty
domain: quality
range: integer

Chemical Ingredients [Chemical/Ingredient]
type: Class
subclass of: material entity
Display_Name: Chemical Ingredients
NUI: N0000000002
RxNorm_CUI: 991181
code: C178
imported from: NDF-RT.owl

Clinical Kinetics [PK]
type: Class
subclass of: process
Display_Name: Clinical Kinetics
NUI: N0000000003
RxNorm_CUI: 1030853
UMLS_CUI: C1373163
code: C180
imported from: NDF-RT.owl

Diseases, Manifestations or Physiologic States [Disease/Finding]
type: Class
subclass of: disposition
Display_Name: Diseases, Manifestations or Physiologic States
NUI: N0000000004
RxNorm_CUI: 989348
UMLS_CUI: C1373233
code: C182
imported from: NDF-RT.owl

Mental Disorders and Manifestations [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Mental Disorders and Manifestations
NUI: N0000000006
RxNorm_CUI: 984721
UMLS_CUI: C2916796
code: C190
imported from: NDF-RT.owl

Infectious Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Infectious Diseases
NUI: N0000000007
RxNorm_CUI: 1023583
SNOMED_CID: 189822004
SNOMED_CID: 190563008
SNOMED_CID: 191415002
SNOMED_CID: 40733004
UMLS_CUI: C0009450
code: C192
imported from: NDF-RT.owl

Elimination [PK]
type: Class
subclass of: Clinical Kinetics [PK]
Display_Name: Elimination
NUI: N0000000022
RxNorm_CUI: 986944
UMLS_CUI: C0221102
code: C222
imported from: NDF-RT.owl

Metabolism [PK]
type: Class
subclass of: Elimination [PK]
Display_Name: Metabolism
NUI: N0000000023
RxNorm_CUI: 1023904
UMLS_CUI: C0025519
code: C224
imported from: NDF-RT.owl

Site of Metabolism [PK]
type: Class
subclass of: Metabolism [PK]
Display_Name: Site of Metabolism
NUI: N0000000024
RxNorm_CUI: 988808
UMLS_CUI: C1373176
code: C226
imported from: NDF-RT.owl

Hepatic Metabolism [PK]
type: Class
subclass of: Site of Metabolism [PK]
Display_Name: Hepatic Metabolism
NUI: N0000000026
RxNorm_CUI: 984512
UMLS_CUI: C1373178
code: C230
imported from: NDF-RT.owl

Route of Excretion [PK]
type: Class
subclass of: Elimination [PK]
Display_Name: Route of Excretion
NUI: N0000000041
RxNorm_CUI: 987962
UMLS_CUI: C1373186
code: C260
imported from: NDF-RT.owl

Renal Excretion [PK]
type: Class
subclass of: Route of Excretion [PK]
Display_Name: Renal Excretion
NUI: N0000000042
RxNorm_CUI: 986666
UMLS_CUI: C1373187
code: C262
imported from: NDF-RT.owl

Physiochemical Activity [MoA]
type: Class
subclass of: Cellular or Molecular Interactions [MoA]
Display_Name: Physiochemical Activity
NUI: N0000000065
RxNorm_CUI: 989958
UMLS_CUI: C1372991
code: C308
imported from: NDF-RT.owl

Small Ion Transport Pump Interactions [MoA]
type: Class
subclass of: Active Transporter Interactions [MoA]
Display_Name: Small Ion Transport Pump Interactions
NUI: N0000000066
RxNorm_CUI: 986087
UMLS_CUI: C1373107
code: C310
imported from: NDF-RT.owl

Active Transporter Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
Display_Name: Active Transporter Interactions
NUI: N0000000072
RxNorm_CUI: 1031287
UMLS_CUI: C1373104
code: C322
imported from: NDF-RT.owl

Immunologic Factors [MoA]
type: Class
subclass of: Immunologic and Biological Factors [MoA]
Display_Name: Immunologic Factors
MeSH_DUI: D007155
MeSH_Name: Immunologic Factors
NUI: N0000000082
RxNorm_CUI: 993127
UMLS_CUI: C2757006
code: C342
imported from: NDF-RT.owl

Receptor Interactions [MoA]
type: Class
subclass of: Cellular or Molecular Interactions [MoA]
Display_Name: Receptor Interactions
NUI: N0000000085
RxNorm_CUI: 988560
UMLS_CUI: C1372999
code: C348
imported from: NDF-RT.owl

Reverse Transcriptase Inhibitors [MoA]
type: Class
subclass of: Nucleic Acid Synthesis Inhibitors [MoA]
Display_Name: Reverse Transcriptase Inhibitors
MeSH_DUI: D018894
MeSH_Name: Reverse Transcriptase Inhibitors
NUI: N0000000103
RxNorm_CUI: 993157
UMLS_CUI: C2757067
code: C384
imported from: NDF-RT.owl

Dopamine Agonists [MoA]
type: Class
subclass of: Dopamine Receptor Interactions [MoA]
Display_Name: Dopamine Agonists
MeSH_DUI: D018491
MeSH_Name: Dopamine Agonists
NUI: N0000000117
RxNorm_CUI: 992714
Synonym: Dopaminergic Agonist
UMLS_CUI: C2757007
code: C412
imported from: NDF-RT.owl

Adrenergic Agonists [MoA]
type: Class
subclass of: Adrenergic Receptor Interactions [MoA]
Display_Name: Adrenergic Agonists
MeSH_DUI: D000322
MeSH_Name: Adrenergic Agonists
NUI: N0000000122
RxNorm_CUI: 1029285
UMLS_CUI: C2757025
code: C422
imported from: NDF-RT.owl

Enzyme Inhibitors [MoA]
type: Class
subclass of: Enzyme Interactions [MoA]
Display_Name: Enzyme Inhibitors
MeSH_DUI: D004791
MeSH_Name: Enzyme Inhibitors
NUI: N0000000133
RxNorm_CUI: 1032544
UMLS_CUI: C2756995
code: C444
imported from: NDF-RT.owl

Biological Macromolecular Activity [MoA]
type: Class
subclass of: Cellular or Molecular Interactions [MoA]
Display_Name: Biological Macromolecular Activity
NUI: N0000000142
RxNorm_CUI: 988641
UMLS_CUI: C2267218
code: C462
imported from: NDF-RT.owl

G-Protein-linked Receptor Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
Display_Name: G-Protein-linked Receptor Interactions
NUI: N0000000152
RxNorm_CUI: 984725
Synonym: G-Protein-linked Receptor-Effector Interactions
UMLS_CUI: C2916797
code: C482
imported from: NDF-RT.owl

Adrenergic Receptor Interactions [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
Display_Name: Adrenergic Receptor Interactions
NUI: N0000000153
RxNorm_CUI: 987972
UMLS_CUI: C1373072
code: C484
imported from: NDF-RT.owl

Enzyme Interactions [MoA]
type: Class
subclass of: Cellular or Molecular Interactions [MoA]
Display_Name: Enzyme Interactions
NUI: N0000000163
RxNorm_CUI: 988200
UMLS_CUI: C1373066
code: C504
imported from: NDF-RT.owl

Cytokine Receptor Superfamily Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
Display_Name: Cytokine Receptor Superfamily Interactions
NUI: N0000000175
RxNorm_CUI: 984937
UMLS_CUI: C1373058
code: C528
imported from: NDF-RT.owl

Ion Channel Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
Display_Name: Ion Channel Interactions
NUI: N0000000193
RxNorm_CUI: 988382
UMLS_CUI: C1373047
code: C564
imported from: NDF-RT.owl

Cholinergic Nicotinic Receptor Interactions [MoA]
type: Class
subclass of: Polycationic Channel Interactions [MoA]
subclass of: Cholinergic Interactions [MoA]
Display_Name: Cholinergic Nicotinic Receptor Interactions
NUI: N0000000199
RxNorm_CUI: 985201
UMLS_CUI: C2267220
code: C576
imported from: NDF-RT.owl

beta Lactamase Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
Display_Name: beta Lactamase Inhibitors
NUI: N0000000202
RxNorm_CUI: 989759
Synonym: beta-Lactamase Inhibitors
UMLS_CUI: C1373040
code: C582
imported from: NDF-RT.owl

Dopamine Receptor Interactions [MoA]
type: Class
subclass of: G-Protein-linked Receptor Interactions [MoA]
Display_Name: Dopamine Receptor Interactions
NUI: N0000000203
RxNorm_CUI: 985948
UMLS_CUI: C1373039
code: C584
imported from: NDF-RT.owl

Electrolyte Activity [MoA]
type: Class
subclass of: Physiochemical Activity [MoA]
Display_Name: Electrolyte Activity
NUI: N0000000220
RxNorm_CUI: 984201
UMLS_CUI: C2267221
code: C618
imported from: NDF-RT.owl

Cellular or Molecular Interactions [MoA]
type: Class
subclass of: role
Display_Name: Cellular or Molecular Interactions
NUI: N0000000223
RxNorm_CUI: 986459
UMLS_CUI: C1373094
code: C624
imported from: NDF-RT.owl

Acid-Base Activity [MoA]
type: Class
subclass of: Physiochemical Activity [MoA]
Display_Name: Acid-Base Activity
NUI: N0000000226
RxNorm_CUI: 985379
UMLS_CUI: C2267222
code: C630
imported from: NDF-RT.owl

Cholinergic Nicotinic Antagonists [MoA]
type: Class
subclass of: Cholinergic Nicotinic Receptor Interactions [MoA]
subclass of: Cholinergic Antagonists [MoA]
Display_Name: Cholinergic Nicotinic Antagonists
NUI: N0000000227
RxNorm_CUI: 989668
UMLS_CUI: C1373090
code: C632
imported from: NDF-RT.owl

Structural Macromolecules [MoA]
type: Class
subclass of: Biological Macromolecular Activity [MoA]
Display_Name: Structural Macromolecules
NUI: N0000000228
RxNorm_CUI: 984803
UMLS_CUI: C1373089
code: C634
imported from: NDF-RT.owl

Nucleic Acid Synthesis Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
Display_Name: Nucleic Acid Synthesis Inhibitors
MeSH_DUI: D019384
MeSH_Name: Nucleic Acid Synthesis Inhibitors
NUI: N0000000233
RxNorm_CUI: 993166
UMLS_CUI: C2757009
code: C644
imported from: NDF-RT.owl

Adrenergic beta-Agonists [MoA]
type: Class
subclass of: Adrenergic Agonists [MoA]
Display_Name: Adrenergic beta-Agonists
MeSH_DUI: D000318
MeSH_Name: Adrenergic beta-Agonists
NUI: N0000000245
RxNorm_CUI: 992727
Synonym: Beta-adrenergic Agonist
UMLS_CUI: C2757043
code: C668
imported from: NDF-RT.owl

Polycationic Channel Interactions [MoA]
type: Class
subclass of: Ion Channel Interactions [MoA]
Display_Name: Polycationic Channel Interactions
NUI: N0000000253
RxNorm_CUI: 990209
UMLS_CUI: C1373076
code: C684
imported from: NDF-RT.owl

Immunologic and Biological Factors [MoA]
type: Class
subclass of: Cellular or Molecular Interactions [MoA]
Display_Name: Immunologic and Biological Factors
MeSH_DUI: D007151
MeSH_Name: Immunologic and Biological Factors
NUI: N0000000254
RxNorm_CUI: 1032698
UMLS_CUI: C0021048
code: C686
imported from: NDF-RT.owl

Congenital Abnormalities [Disease/Finding]
type: Class
subclass of: Congenital, Hereditary, and Neonatal Diseases and Abnormalities [Disease/Finding]
Display_Name: Congenital Abnormalities
MeSH_CUI: M0000013
MeSH_DUI: D000013
MeSH_Definition: Malformations of organs or body parts during development in utero.
MeSH_Name: Congenital Abnormalities
NUI: N0000000264
RxNorm_CUI: 1021840
SNOMED_CID: 276654001
SNOMED_CID: 276655000
SNOMED_CID: 276720006
Synonym: Abnormalities, Congenital
Synonym: Birth Defects
Synonym: Congenital Defects
Synonym: Defects, Congenital
Synonym: Deformities
UMLS_CUI: C0000768
code: C706
imported from: NDF-RT.owl

Abnormalities, Drug-Induced [Disease/Finding]
type: Class
subclass of: Congenital Abnormalities [Disease/Finding]
Display_Name: Abnormalities, Drug-Induced
MeSH_CUI: M0000014
MeSH_DUI: D000014
MeSH_Definition: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
MeSH_Name: Abnormalities, Drug-Induced
NUI: N0000000265
RxNorm_CUI: 989962
Synonym: Drug-Induced Abnormalities
UMLS_CUI: C0000771
code: C708
imported from: NDF-RT.owl

Acid-Base Imbalance [Disease/Finding]
type: Class
subclass of: Metabolic Diseases [Disease/Finding]
Display_Name: Acid-Base Imbalance
MeSH_CUI: M0000212
MeSH_DUI: D000137
MeSH_Definition: Disturbances in the ACID-BASE EQUILIBRIUM of the body.
MeSH_Name: Acid-Base Imbalance
NUI: N0000000282
RxNorm_CUI: 1026879
UMLS_CUI: C0001118
code: C742
imported from: NDF-RT.owl

Acidosis [Disease/Finding]
type: Class
subclass of: Acid-Base Imbalance [Disease/Finding]
Display_Name: Acidosis
MeSH_CUI: M0000213
MeSH_DUI: D000138
MeSH_Definition: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
MeSH_Name: Acidosis
NUI: N0000000283
RxNorm_CUI: 1023565
SNOMED_CID: 51387008
UMLS_CUI: C0001122
code: C744
imported from: NDF-RT.owl

Alcohol Withdrawal Delirium [Disease/Finding]
type: Class
subclass of: Substance Withdrawal Syndrome [Disease/Finding]
subclass of: Alcohol-Induced Disorders, Nervous System [Disease/Finding]
Display_Name: Alcohol Withdrawal Delirium
MeSH_CUI: M0000652
MeSH_DUI: D000430
MeSH_Definition: An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)
MeSH_Name: Alcohol Withdrawal Delirium
NUI: N0000000351
RxNorm_CUI: 1023188
SNOMED_CID: 8635005
Synonym: Alcohol Withdrawal-Induced Delirium Tremens
Synonym: Delirium Tremens
Synonym: Delirium Tremens, Alcohol Withdrawal Induced
UMLS_CUI: C0001957
code: C880
imported from: NDF-RT.owl

Alkalosis [Disease/Finding]
type: Class
subclass of: Acid-Base Imbalance [Disease/Finding]
Display_Name: Alkalosis
MeSH_CUI: M0000714
MeSH_DUI: D000471
MeSH_Definition: A pathological condition that removes acid or adds base to the body fluids.
MeSH_Name: Alkalosis
NUI: N0000000355
RxNorm_CUI: 1025787
SNOMED_CID: 21420006
UMLS_CUI: C0002063
code: C888
imported from: NDF-RT.owl

Anuria [Disease/Finding]
type: Class
subclass of: Kidney Diseases [Disease/Finding]
subclass of: Urination Disorders [Disease/Finding]
Display_Name: Anuria
MeSH_CUI: M0001524
MeSH_DUI: D001002
MeSH_Definition: Absence of urine formation. It is usually associated with complete bilateral ureteral (URETER) obstruction, complete lower urinary tract obstruction, or unilateral ureteral obstruction when a solitary kidney is present.
MeSH_Name: Anuria
NUI: N0000000431
RxNorm_CUI: 1023563
SNOMED_CID: 2472002
UMLS_CUI: C0003460
code: C1040
imported from: NDF-RT.owl

Aortic Stenosis, Subvalvular [Disease/Finding]
type: Class
subclass of: Aortic Valve Stenosis [Disease/Finding]
Display_Name: Aortic Stenosis, Subvalvular
MeSH_CUI: M0001552
MeSH_DUI: D001020
MeSH_Definition: A pathological constriction occurring in the region below the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
MeSH_Name: Aortic Stenosis, Subvalvular
NUI: N0000000442
RxNorm_CUI: 1025918
Synonym: Aortic Subvalvular Stenosis
Synonym: Subvalvular Aortic Stenosis
UMLS_CUI: C0003500
code: C1062
imported from: NDF-RT.owl

Aortic Valve Stenosis [Disease/Finding]
type: Class
subclass of: Heart Valve Diseases [Disease/Finding]
subclass of: Ventricular Outflow Obstruction [Disease/Finding]
Display_Name: Aortic Valve Stenosis
MeSH_CUI: M0001557
MeSH_DUI: D001024
MeSH_Definition: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
MeSH_Name: Aortic Valve Stenosis
NUI: N0000000445
RxNorm_CUI: 1021926
SNOMED_CID: 60573004
Synonym: Aortic Stenosis
UMLS_CUI: C0003507
code: C1068
imported from: NDF-RT.owl

Arrhythmias, Cardiac [Disease/Finding]
type: Class
subclass of: Heart Diseases [Disease/Finding]
subclass of: Pathologic Processes [Disease/Finding]
Display_Name: Arrhythmias, Cardiac
MeSH_CUI: M0001715
MeSH_DUI: D001145
MeSH_Definition: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
MeSH_Name: Arrhythmias, Cardiac
NUI: N0000000469
RxNorm_CUI: 1023395
SNOMED_CID: 195107004
Synonym: Arrhythmia
Synonym: Arrythmia
Synonym: Cardiac Arrhythmia
Synonym: Cardiac Arrhythmias
Synonym: Cardiac Dysrhythmia
UMLS_CUI: C0003811
code: C1116
imported from: NDF-RT.owl

Ascites [Disease/Finding]
type: Class
subclass of: Pathologic Processes [Disease/Finding]
Display_Name: Ascites
MeSH_CUI: M0001791
MeSH_DUI: D001201
MeSH_Definition: Accumulation or retention of free fluid within the peritoneal cavity.
MeSH_Name: Ascites
NUI: N0000000490
RxNorm_CUI: 1021930
SNOMED_CID: 389026000
UMLS_CUI: C0003962
code: C1158
imported from: NDF-RT.owl

Bacterial Infections and Mycoses [Disease/Finding]
type: Class
subclass of: Infectious Diseases [Disease/Finding]
Display_Name: Bacterial Infections and Mycoses
MeSH_CUI: M0002125
MeSH_DUI: D001423
MeSH_Definition: Infections caused by bacteria and fungi, general, specified, or unspecified.
MeSH_Name: Bacterial Infections and Mycoses
NUI: N0000000523
RxNorm_CUI: 986958
UMLS_CUI: C0004615
code: C1224
imported from: NDF-RT.owl

Mental Disorders [Disease/Finding]
type: Class
subclass of: Mental Disorders and Manifestations [Disease/Finding]
Display_Name: Mental Disorders
MeSH_CUI: M0002289
MeSH_DUI: D001523
MeSH_Definition: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
MeSH_Name: Mental Disorders
NUI: N0000000538
RxNorm_CUI: 1022308
SNOMED_CID: 74732009
UMLS_CUI: C0004936
code: C1254
imported from: NDF-RT.owl

Blood Coagulation Disorders [Disease/Finding]
type: Class
subclass of: Hematologic Diseases [Disease/Finding]
Display_Name: Blood Coagulation Disorders
MeSH_CUI: M0002683
MeSH_DUI: D001778
MeSH_Definition: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
MeSH_Name: Blood Coagulation Disorders
NUI: N0000000575
RxNorm_CUI: 1022276
SNOMED_CID: 362970003
SNOMED_CID: 64779008
Synonym: Coagulation Disorders, Blood
Synonym: Disorders, Blood Coagulation
UMLS_CUI: C0005779
code: C1328
imported from: NDF-RT.owl

Bone Diseases [Disease/Finding]
type: Class
subclass of: Musculoskeletal Diseases [Disease/Finding]
Display_Name: Bone Diseases
MeSH_CUI: M0002776
MeSH_DUI: D001847
MeSH_Definition: Diseases of BONES.
MeSH_Name: Bone Diseases
NUI: N0000000584
RxNorm_CUI: 1025929
SNOMED_CID: 308147009
SNOMED_CID: 76069003
UMLS_CUI: C0005940
code: C1346
imported from: NDF-RT.owl

Bone Diseases, Metabolic [Disease/Finding]
type: Class
subclass of: Bone Diseases [Disease/Finding]
Display_Name: Bone Diseases, Metabolic
MeSH_CUI: M0002780
MeSH_DUI: D001851
MeSH_Name: Bone Diseases, Metabolic
NUI: N0000000588
RxNorm_CUI: 1026469
SNOMED_CID: 50279003
Synonym: Metabolic Bone Diseases
UMLS_CUI: C0005944
code: C1354
imported from: NDF-RT.owl

Bradycardia [Disease/Finding]
type: Class
subclass of: Arrhythmias, Cardiac [Disease/Finding]
Display_Name: Bradycardia
MeSH_CUI: M0002863
MeSH_DUI: D001919
MeSH_Definition: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
MeSH_Name: Bradycardia
NUI: N0000000600
RxNorm_CUI: 1025503
SNOMED_CID: 48867003
Synonym: Bradyarrhythmia
Synonym: Bradyarrhythmias
UMLS_CUI: C0428977
code: C1378
imported from: NDF-RT.owl

Brain Diseases [Disease/Finding]
type: Class
subclass of: Central Nervous System Diseases [Disease/Finding]
Display_Name: Brain Diseases
MeSH_CUI: M0002874
MeSH_DUI: D001927
MeSH_Definition: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
MeSH_Name: Brain Diseases
NUI: N0000000605
RxNorm_CUI: 986258
SNOMED_CID: 81308009
Synonym: Brain Disorders
Synonym: CNS Disorders, Intracranial
Synonym: Central Nervous System Disorders, Intracranial
Synonym: Central Nervous System Intracranial Disorders
Synonym: Encephalon Diseases
Synonym: Intracranial CNS Disorders
Synonym: Intracranial Central Nervous System Disorders
UMLS_CUI: C0006111
code: C1388
imported from: NDF-RT.owl

Calcium Metabolism Disorders [Disease/Finding]
type: Class
subclass of: Metabolic Diseases [Disease/Finding]
Display_Name: Calcium Metabolism Disorders
MeSH_CUI: M0003174
MeSH_DUI: D002128
MeSH_Definition: Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.
MeSH_Name: Calcium Metabolism Disorders
NUI: N0000000646
RxNorm_CUI: 1024541
SNOMED_CID: 71638002
UMLS_CUI: C0006705
code: C1470
imported from: NDF-RT.owl

Calculi [Disease/Finding]
type: Class
subclass of: Pathological Conditions, Anatomical [Disease/Finding]
Display_Name: Calculi
MeSH_CUI: M0003195
MeSH_DUI: D002137
MeSH_Definition: An abnormal concretion occurring mostly in the urinary and biliary tracts, usually composed of mineral salts. Also called stones.
MeSH_Name: Calculi
NUI: N0000000647
RxNorm_CUI: 1026851
SNOMED_CID: 125243009
SNOMED_CID: 56381008
Synonym: Biliary or Urinary Stones
UMLS_CUI: C0006736
code: C1472
imported from: NDF-RT.owl

Candidiasis [Disease/Finding]
type: Class
subclass of: Mycoses [Disease/Finding]
Display_Name: Candidiasis
MeSH_CUI: M0003258
MeSH_DUI: D002177
MeSH_Definition: Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)
MeSH_Name: Candidiasis
NUI: N0000000650
RxNorm_CUI: 1022538
SNOMED_CID: 78048006
Synonym: Moniliasis
UMLS_CUI: C0006840
code: C1478
imported from: NDF-RT.owl

Candidiasis, Chronic Mucocutaneous [Disease/Finding]
type: Class
subclass of: Candidiasis [Disease/Finding]
subclass of: Dermatomycoses [Disease/Finding]
Display_Name: Candidiasis, Chronic Mucocutaneous
MeSH_CUI: M0003259
MeSH_DUI: D002178
MeSH_Definition: A clinical syndrome characterized by development, usually in infancy or childhood, of a chronic, often widespread candidiasis of skin, nails, and mucous membranes. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait, or associated with defects in cell-mediated immunity, endocrine disorders, dental stomatitis, or malignancy.
MeSH_Name: Candidiasis, Chronic Mucocutaneous
NUI: N0000000651
RxNorm_CUI: 1023229
SNOMED_CID: 234568006
UMLS_CUI: C0006845
code: C1480
imported from: NDF-RT.owl

Candidiasis, Cutaneous [Disease/Finding]
type: Class
subclass of: Candidiasis [Disease/Finding]
subclass of: Dermatomycoses [Disease/Finding]
Display_Name: Candidiasis, Cutaneous
MeSH_CUI: M0003260
MeSH_DUI: D002179
MeSH_Definition: Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)
MeSH_Name: Candidiasis, Cutaneous
NUI: N0000000652
RxNorm_CUI: 1025470
SNOMED_CID: 49883006
Synonym: Moniliasis, Cutaneous
UMLS_CUI: C0006846
code: C1482
imported from: NDF-RT.owl

Candidiasis, Oral [Disease/Finding]
type: Class
subclass of: Candidiasis [Disease/Finding]
subclass of: Mouth Diseases [Disease/Finding]
Display_Name: Candidiasis, Oral
MeSH_CUI: M0003261
MeSH_DUI: D002180
MeSH_Definition: Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)
MeSH_Name: Candidiasis, Oral
NUI: N0000000653
RxNorm_CUI: 1022622
SNOMED_CID: 79740000
Synonym: Moniliasis, Oral
Synonym: Thrush
UMLS_CUI: C0006849
code: C1484
imported from: NDF-RT.owl

Candidiasis, Vulvovaginal [Disease/Finding]
type: Class
subclass of: Candidiasis [Disease/Finding]
subclass of: Vulvovaginitis [Disease/Finding]
Display_Name: Candidiasis, Vulvovaginal
MeSH_CUI: M0003262
MeSH_DUI: D002181
MeSH_Definition: Infection of the VULVA and VAGINA with a fungus of the genus CANDIDA.
MeSH_Name: Candidiasis, Vulvovaginal
NUI: N0000000654
RxNorm_CUI: 1024776
SNOMED_CID: 72605008
Synonym: Moniliasis, Vulvovaginal
UMLS_CUI: C0700345
code: C1486
imported from: NDF-RT.owl

Cardiac Output, Low [Disease/Finding]
type: Class
subclass of: Heart Diseases [Disease/Finding]
subclass of: Signs and Symptoms [Disease/Finding]
Display_Name: Cardiac Output, Low
MeSH_CUI: M0003453
MeSH_DUI: D002303
MeSH_Definition: A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
MeSH_Name: Cardiac Output, Low
NUI: N0000000683
RxNorm_CUI: 1024618
SNOMED_CID: 86318000
Synonym: Low Cardiac Output
UMLS_CUI: C0007166
code: C1544
imported from: NDF-RT.owl

Cardiovascular Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Cardiovascular Diseases
MeSH_CUI: M0003473
MeSH_DUI: D002318
MeSH_Definition: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
MeSH_Name: Cardiovascular Diseases
NUI: N0000000689
RxNorm_CUI: 1022075
SNOMED_CID: 105980002
SNOMED_CID: 49601007
UMLS_CUI: C0007222
code: C1556
imported from: NDF-RT.owl

Central Nervous System Diseases [Disease/Finding]
type: Class
subclass of: Nervous System Diseases [Disease/Finding]
Display_Name: Central Nervous System Diseases
MeSH_CUI: M0003805
MeSH_DUI: D002493
MeSH_Definition: Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.
MeSH_Name: Central Nervous System Diseases
NUI: N0000000709
RxNorm_CUI: 1023588
SNOMED_CID: 23853001
Synonym: CNS Diseases
Synonym: Central Nervous System Disorders
UMLS_CUI: C0007682
code: C1596
imported from: NDF-RT.owl

Cerebrovascular Disorders [Disease/Finding]
type: Class
subclass of: Brain Diseases [Disease/Finding]
subclass of: Vascular Diseases [Disease/Finding]
Display_Name: Cerebrovascular Disorders
MeSH_CUI: M0003914
MeSH_DUI: D002561
MeSH_Definition: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES; or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
MeSH_Name: Cerebrovascular Disorders
NUI: N0000000730
RxNorm_CUI: 1022010
SNOMED_CID: 62914000
Synonym: Brain Vascular Disorders
Synonym: Intracranial Vascular Disorders
Synonym: Vascular Diseases, Intracranial
UMLS_CUI: C0007820
code: C1638
imported from: NDF-RT.owl

Coma [Disease/Finding]
type: Class
subclass of: Unconsciousness [Disease/Finding]
Display_Name: Coma
MeSH_CUI: M0004841
MeSH_DUI: D003128
MeSH_Definition: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
MeSH_Name: Coma
NUI: N0000000819
RxNorm_CUI: 988251
SNOMED_CID: 371632003
Synonym: Comatose
UMLS_CUI: C0009421
code: C1816
imported from: NDF-RT.owl

Consciousness Disorders [Disease/Finding]
type: Class
subclass of: Neurobehavioral Manifestations [Disease/Finding]
subclass of: Delirium, Dementia, Amnestic, Cognitive Disorders [Disease/Finding]
Display_Name: Consciousness Disorders
MeSH_CUI: M0005031
MeSH_DUI: D003244
MeSH_Definition: Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. Dysfunction of the cerebral hemispheres or brain stem RETICULAR FORMATION may result in this condition.
MeSH_Name: Consciousness Disorders
NUI: N0000000840
RxNorm_CUI: 1031236
UMLS_CUI: C0009792
code: C1858
imported from: NDF-RT.owl

Corneal Diseases [Disease/Finding]
type: Class
subclass of: Eye Diseases [Disease/Finding]
Display_Name: Corneal Diseases
MeSH_CUI: M0005177
MeSH_DUI: D003316
MeSH_Definition: Diseases of the cornea.
MeSH_Name: Corneal Diseases
NUI: N0000000851
RxNorm_CUI: 1024256
SNOMED_CID: 15250008
UMLS_CUI: C0010034
code: C1880
imported from: NDF-RT.owl

Crohn Disease [Disease/Finding]
type: Class
subclass of: Inflammatory Bowel Diseases [Disease/Finding]
Display_Name: Crohn Disease
MeSH_CUI: M0005335
MeSH_DUI: D003424
MeSH_Definition: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
MeSH_Name: Crohn Disease
NUI: N0000000875
RxNorm_CUI: 1024195
SNOMED_CID: 34000006
Synonym: Crohn's Disease
UMLS_CUI: C0010346
code: C1928
imported from: NDF-RT.owl

Cytomegalovirus Infections [Disease/Finding]
type: Class
subclass of: Herpesviridae Infections [Disease/Finding]
Display_Name: Cytomegalovirus Infections
MeSH_CUI: M0005604
MeSH_DUI: D003586
MeSH_Definition: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
MeSH_Name: Cytomegalovirus Infections
NUI: N0000000897
RxNorm_CUI: 1023187
SNOMED_CID: 28944009
Synonym: Cytomegalic Inclusion Disease
Synonym: Inclusion Disease
Synonym: Infections, Cytomegalovirus
Synonym: Salivary Gland Virus Disease
UMLS_CUI: C0010823
code: C1972
imported from: NDF-RT.owl

Deficiency Diseases [Disease/Finding]
type: Class
subclass of: Malnutrition [Disease/Finding]
Display_Name: Deficiency Diseases
MeSH_CUI: M0005753
MeSH_DUI: D003677
MeSH_Definition: A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)
MeSH_Name: Deficiency Diseases
NUI: N0000000909
RxNorm_CUI: 1025258
UMLS_CUI: C0011156
code: C1996
imported from: NDF-RT.owl

Dehydration [Disease/Finding]
type: Class
subclass of: Pathologic Processes [Disease/Finding]
subclass of: Water-Electrolyte Imbalance [Disease/Finding]
Display_Name: Dehydration
MeSH_CUI: M0005757
MeSH_DUI: D003681
MeSH_Definition: The condition that results from excessive loss of water from a living organism.
MeSH_Name: Dehydration
NUI: N0000000911
RxNorm_CUI: 1023412
SNOMED_CID: 34095006
UMLS_CUI: C0011175
code: C2000
imported from: NDF-RT.owl

Dermatitis [Disease/Finding]
type: Class
subclass of: Skin Diseases [Disease/Finding]
Display_Name: Dermatitis
MeSH_CUI: M0006046
MeSH_DUI: D003872
MeSH_Definition: Any inflammation of the skin.
MeSH_Name: Dermatitis
NUI: N0000000939
RxNorm_CUI: 1023378
SNOMED_CID: 182782007
UMLS_CUI: C0011603
code: C2056
imported from: NDF-RT.owl

Dermatitis, Atopic [Disease/Finding]
type: Class
subclass of: Dermatitis [Disease/Finding]
subclass of: Hypersensitivity, Immediate [Disease/Finding]
subclass of: Skin Diseases, Genetic [Disease/Finding]
subclass of: Skin Diseases, Eczematous [Disease/Finding]
Display_Name: Dermatitis, Atopic
MeSH_CUI: M0006050
MeSH_DUI: D003876
MeSH_Definition: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
MeSH_Name: Dermatitis, Atopic
NUI: N0000000943
RxNorm_CUI: 1022124
SNOMED_CID: 200773006
SNOMED_CID: 200775004
SNOMED_CID: 24079001
Synonym: Eczema, Atopic
Synonym: Neurodermatitis, Atopic
Synonym: Neurodermatitis, Disseminated
UMLS_CUI: C0011615
code: C2064
imported from: NDF-RT.owl

Dermatomycoses [Disease/Finding]
type: Class
subclass of: Mycoses [Disease/Finding]
subclass of: Skin Diseases, Infectious [Disease/Finding]
Display_Name: Dermatomycoses
MeSH_CUI: M0006059
MeSH_DUI: D003881
MeSH_Definition: Superficial infections of the skin or its appendages by any of various fungi.
MeSH_Name: Dermatomycoses
NUI: N0000000945
RxNorm_CUI: 1021749
SNOMED_CID: 14560005
SNOMED_CID: 276206000
Synonym: Dermatomycosis
Synonym: Fungal Skin Diseases
Synonym: Skin Diseases, Fungal
UMLS_CUI: C0011630
code: C2068
imported from: NDF-RT.owl

Digestive System Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Digestive System Diseases
MeSH_CUI: M0006374
MeSH_DUI: D004066
MeSH_Definition: Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).
MeSH_Name: Digestive System Diseases
NUI: N0000000973
RxNorm_CUI: 1023342
SNOMED_CID: 53619000
UMLS_CUI: C0012242
code: C2124
imported from: NDF-RT.owl

DNA Virus Infections [Disease/Finding]
type: Class
subclass of: Virus Diseases [Disease/Finding]
Display_Name: DNA Virus Infections
MeSH_CUI: M0006675
MeSH_DUI: D004266
MeSH_Name: DNA Virus Infections
NUI: N0000000993
RxNorm_CUI: 1027612
Synonym: Infections, DNA Virus
UMLS_CUI: C0012922
code: C2164
imported from: NDF-RT.owl

Drug Hypersensitivity [Disease/Finding]
type: Class
subclass of: Hypersensitivity [Disease/Finding]
Display_Name: Drug Hypersensitivity
MeSH_CUI: M0006829
MeSH_DUI: D004342
MeSH_Definition: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
MeSH_Name: Drug Hypersensitivity
NUI: N0000000999
RxNorm_CUI: 1024684
SNOMED_CID: 416093006
SNOMED_CID: 416098002
Synonym: Allergy, Drug
Synonym: Drug Allergy
Synonym: Hypersensitivity, Drug
UMLS_CUI: C0013182
code: C2176
imported from: NDF-RT.owl

Drug Toxicity [Disease/Finding]
type: Class
subclass of: Poisoning [Disease/Finding]
Display_Name: Drug Toxicity
MeSH_CUI: M0006855
MeSH_DUI: D004362
MeSH_Definition: Manifestations of the adverse effects of drugs administered therapeutically or in the course of diagnostic techniques. It does not include accidental or intentional poisoning for which specific headings are available.
MeSH_Name: Drug Toxicity
NUI: N0000001000
RxNorm_CUI: 1022029
SNOMED_CID: 7895008
Synonym: Toxicity, Drug
UMLS_CUI: C0013221
code: C2178
imported from: NDF-RT.owl

Edema [Disease/Finding]
type: Class
subclass of: Signs and Symptoms [Disease/Finding]
Display_Name: Edema
MeSH_CUI: M0007051
MeSH_DUI: D004487
MeSH_Definition: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
MeSH_Name: Edema
NUI: N0000001057
RxNorm_CUI: 1022374
SNOMED_CID: 20741006
SNOMED_CID: 79654002
Synonym: Dropsy
Synonym: Hydrops
UMLS_CUI: C0013604
code: C2292
imported from: NDF-RT.owl

Eye Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Eye Diseases
MeSH_CUI: M0008088
MeSH_DUI: D005128
MeSH_Name: Eye Diseases
NUI: N0000001181
RxNorm_CUI: 1023594
SNOMED_CID: 194183009
UMLS_CUI: C0015397
code: C2540
imported from: NDF-RT.owl

Female Urogenital Diseases and Pregnancy Complications [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Female Urogenital Diseases and Pregnancy Complications
MeSH_CUI: M0008309
MeSH_DUI: D005261
MeSH_Definition: Pathological processes of the female URINARY TRACT, the reproductive system (GENITALIA, FEMALE), and disorders related to PREGNANCY.
MeSH_Name: Female Urogenital Diseases and Pregnancy Complications
NUI: N0000001224
RxNorm_CUI: 985609
UMLS_CUI: C1720765
code: C2626
imported from: NDF-RT.owl

Food Hypersensitivity [Disease/Finding]
type: Class
subclass of: Hypersensitivity, Immediate [Disease/Finding]
Display_Name: Food Hypersensitivity
MeSH_CUI: M0008686
MeSH_DUI: D005512
MeSH_Definition: Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
MeSH_Name: Food Hypersensitivity
NUI: N0000001270
RxNorm_CUI: 1025015
SNOMED_CID: 414285001
Synonym: Allergy, Food
Synonym: Food Allergy
Synonym: Hypersensitivity, Food
UMLS_CUI: C0016470
code: C2718
imported from: NDF-RT.owl

Gastroenteritis [Disease/Finding]
type: Class
subclass of: Gastrointestinal Diseases [Disease/Finding]
Display_Name: Gastroenteritis
MeSH_CUI: M0009018
MeSH_DUI: D005759
MeSH_Definition: INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.
MeSH_Name: Gastroenteritis
NUI: N0000001317
RxNorm_CUI: 1024672
SNOMED_CID: 25374005
UMLS_CUI: C0017160
code: C2812
imported from: NDF-RT.owl

Gastrointestinal Diseases [Disease/Finding]
type: Class
subclass of: Digestive System Diseases [Disease/Finding]
Display_Name: Gastrointestinal Diseases
MeSH_CUI: M0009033
MeSH_DUI: D005767
MeSH_Definition: Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
MeSH_Name: Gastrointestinal Diseases
NUI: N0000001320
RxNorm_CUI: 1022118
SNOMED_CID: 119292006
UMLS_CUI: C0017178
code: C2818
imported from: NDF-RT.owl

Genital Diseases, Female [Disease/Finding]
type: Class
subclass of: Female Urogenital Diseases [Disease/Finding]
Display_Name: Genital Diseases, Female
MeSH_CUI: M0009154
MeSH_DUI: D005831
MeSH_Definition: Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).
MeSH_Name: Genital Diseases, Female
NUI: N0000001323
RxNorm_CUI: 1026095
SNOMED_CID: 244938009
SNOMED_CID: 310789003
Synonym: Female Genital Diseases
Synonym: Gynecologic Diseases
UMLS_CUI: C0017411
code: C2824
imported from: NDF-RT.owl

Genital Diseases, Male [Disease/Finding]
type: Class
subclass of: Male Urogenital Diseases [Disease/Finding]
Display_Name: Genital Diseases, Male
MeSH_CUI: M0009155
MeSH_DUI: D005832
MeSH_Definition: Pathological processes involving the male reproductive tract (GENITALIA, MALE).
MeSH_Name: Genital Diseases, Male
NUI: N0000001324
RxNorm_CUI: 1021837
SNOMED_CID: 64557000
Synonym: Male Genital Diseases
UMLS_CUI: C0017412
code: C2826
imported from: NDF-RT.owl

Graft vs Host Disease [Disease/Finding]
type: Class
subclass of: Immune System Diseases [Disease/Finding]
Display_Name: Graft vs Host Disease
MeSH_CUI: M0009578
MeSH_DUI: D006086
MeSH_Definition: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
MeSH_Name: Graft vs Host Disease
NUI: N0000001384
RxNorm_CUI: 1024721
SNOMED_CID: 234646005
Synonym: Graft-Versus-Host Disease
Synonym: Graft-vs-Host Disease
Synonym: Homologous Wasting Disease
Synonym: Runt Disease
UMLS_CUI: C0018133
code: C2946
imported from: NDF-RT.owl

Heart Arrest [Disease/Finding]
type: Class
subclass of: Heart Diseases [Disease/Finding]
Display_Name: Heart Arrest
MeSH_CUI: M0009938
MeSH_DUI: D006323
MeSH_Definition: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
MeSH_Name: Heart Arrest
NUI: N0000001429
RxNorm_CUI: 1025093
SNOMED_CID: 309810002
SNOMED_CID: 397829000
SNOMED_CID: 410429000
Synonym: Asystole
Synonym: Cardiac Arrest
UMLS_CUI: C0018790
code: C3036
imported from: NDF-RT.owl

Heart Block [Disease/Finding]
type: Class
subclass of: Arrhythmias, Cardiac [Disease/Finding]
Display_Name: Heart Block
MeSH_CUI: M0009945
MeSH_DUI: D006327
MeSH_Definition: Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
MeSH_Name: Heart Block
NUI: N0000001430
RxNorm_CUI: 1023276
SNOMED_CID: 233916004
UMLS_CUI: C0018794
code: C3038
imported from: NDF-RT.owl

Heart Diseases [Disease/Finding]
type: Class
subclass of: Cardiovascular Diseases [Disease/Finding]
Display_Name: Heart Diseases
MeSH_CUI: M0009951
MeSH_DUI: D006331
MeSH_Definition: Pathological conditions involving the HEART including its structural and functional abnormalities.
MeSH_Name: Heart Diseases
NUI: N0000001432
RxNorm_CUI: 1022072
SNOMED_CID: 56265001
Synonym: Cardiac Diseases
UMLS_CUI: C0018799
code: C3042
imported from: NDF-RT.owl

Heart Failure [Disease/Finding]
type: Class
subclass of: Heart Diseases [Disease/Finding]
Display_Name: Heart Failure
MeSH_CUI: M0009953
MeSH_DUI: D006333
MeSH_Definition: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
MeSH_Name: Heart Failure
NUI: N0000001434
RxNorm_CUI: 1024953
SNOMED_CID: 42343007
Synonym: Cardiac Failure
UMLS_CUI: C0018802
code: C3046
imported from: NDF-RT.owl

Heart Valve Diseases [Disease/Finding]
type: Class
subclass of: Heart Diseases [Disease/Finding]
Display_Name: Heart Valve Diseases
MeSH_CUI: M0009972
MeSH_DUI: D006349
MeSH_Definition: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
MeSH_Name: Heart Valve Diseases
NUI: N0000001443
RxNorm_CUI: 989613
SNOMED_CID: 368009
Synonym: Valvular Heart Diseases
UMLS_CUI: C0018824
code: C3064
imported from: NDF-RT.owl

Hematologic Diseases [Disease/Finding]
type: Class
subclass of: Hemic and Lymphatic Diseases [Disease/Finding]
Display_Name: Hematologic Diseases
MeSH_CUI: M0010044
MeSH_DUI: D006402
MeSH_Definition: Disorders of the blood and blood forming tissues.
MeSH_Name: Hematologic Diseases
NUI: N0000001459
RxNorm_CUI: 1021953
SNOMED_CID: 191402006
SNOMED_CID: 267573000
Synonym: Blood Diseases
Synonym: Hematological Diseases
UMLS_CUI: C0018939
code: C3096
imported from: NDF-RT.owl

Hemic and Lymphatic Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Hemic and Lymphatic Diseases
MeSH_CUI: M0010072
MeSH_DUI: D006425
MeSH_Definition: Hematologic diseases and diseases of the lymphatic system collectively. Hemic diseases include disorders involving the formed elements (e.g., ERYTHROCYTE AGGREGATION, INTRAVASCULAR) and chemical components (e.g., BLOOD PROTEIN DISORDERS); lymphatic diseases include disorders relating to lymph, lymph nodes, and lymphocytes.
MeSH_Name: Hemic and Lymphatic Diseases
NUI: N0000001466
RxNorm_CUI: 1026878
UMLS_CUI: C0018981
code: C3110
imported from: NDF-RT.owl

Hemorrhage [Disease/Finding]
type: Class
subclass of: Pathologic Processes [Disease/Finding]
Display_Name: Hemorrhage
MeSH_CUI: M0010152
MeSH_DUI: D006470
MeSH_Definition: Bleeding or escape of blood from a vessel.
MeSH_Name: Hemorrhage
NUI: N0000001481
RxNorm_CUI: 1023287
SNOMED_CID: 195511004
Synonym: Bleeding
UMLS_CUI: C0019080
code: C3140
imported from: NDF-RT.owl

Hemorrhagic Disorders [Disease/Finding]
type: Class
subclass of: Hematologic Diseases [Disease/Finding]
Display_Name: Hemorrhagic Disorders
MeSH_CUI: M0010157
MeSH_DUI: D006474
MeSH_Definition: Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).
MeSH_Name: Hemorrhagic Disorders
NUI: N0000001485
RxNorm_CUI: 1023732
SNOMED_CID: 191331006
Synonym: Hemorrhagic Diathesis
UMLS_CUI: C0019087
code: C3148
imported from: NDF-RT.owl

Hepatitis [Disease/Finding]
type: Class
subclass of: Liver Diseases [Disease/Finding]
Display_Name: Hepatitis
MeSH_CUI: M0010205
MeSH_DUI: D006505
MeSH_Definition: INFLAMMATION of the LIVER.
MeSH_Name: Hepatitis
NUI: N0000001499
RxNorm_CUI: 989819
SNOMED_CID: 128241005
SNOMED_CID: 197351001
UMLS_CUI: C0019158
code: C3176
imported from: NDF-RT.owl

Herpes Genitalis [Disease/Finding]
type: Class
subclass of: Herpes Simplex [Disease/Finding]
subclass of: Sexually Transmitted Diseases, Viral [Disease/Finding]
Display_Name: Herpes Genitalis
MeSH_CUI: M0010276
MeSH_DUI: D006558
MeSH_Definition: Infection of the genitals (GENITALIA) with HERPES SIMPLEX VIRUS in either the males or the females.
MeSH_Name: Herpes Genitalis
NUI: N0000001527
RxNorm_CUI: 1025755
SNOMED_CID: 271463009
SNOMED_CID: 33839006
Synonym: Genital Herpes
Synonym: Herpes Simplex Virus Genital Infection
Synonym: Herpes Simplex, Genital
UMLS_CUI: C0019342
code: C3232
imported from: NDF-RT.owl

Herpes Simplex [Disease/Finding]
type: Class
subclass of: Herpesviridae Infections [Disease/Finding]
subclass of: Skin Diseases, Viral [Disease/Finding]
Display_Name: Herpes Simplex
MeSH_CUI: M0010279
MeSH_DUI: D006561
MeSH_Definition: A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)
MeSH_Name: Herpes Simplex
NUI: N0000001530
RxNorm_CUI: 1023866
SNOMED_CID: 88594005
UMLS_CUI: C0019348
code: C3238
imported from: NDF-RT.owl

Herpesviridae Infections [Disease/Finding]
type: Class
subclass of: DNA Virus Infections [Disease/Finding]
Display_Name: Herpesviridae Infections
MeSH_CUI: M0010285
MeSH_DUI: D006566
MeSH_Definition: Virus diseases caused by the HERPESVIRIDAE.
MeSH_Name: Herpesviridae Infections
NUI: N0000001533
RxNorm_CUI: 1024733
SNOMED_CID: 23513009
Synonym: Herpesvirus Infections
Synonym: Infections, Herpesviridae
Synonym: Infections, Herpesvirus
UMLS_CUI: C0019372
code: C3244
imported from: NDF-RT.owl

Hypercalcemia [Disease/Finding]
type: Class
subclass of: Calcium Metabolism Disorders [Disease/Finding]
subclass of: Water-Electrolyte Imbalance [Disease/Finding]
Display_Name: Hypercalcemia
MeSH_CUI: M0010814
MeSH_DUI: D006934
MeSH_Definition: Abnormally high level of calcium in the blood.
MeSH_Name: Hypercalcemia
NUI: N0000001577
RxNorm_CUI: 1026898
SNOMED_CID: 66931009
UMLS_CUI: C0020437
code: C3332
imported from: NDF-RT.owl

Hyperglycemia [Disease/Finding]
type: Class
subclass of: Glucose Metabolism Disorders [Disease/Finding]
Display_Name: Hyperglycemia
MeSH_CUI: M0010824
MeSH_DUI: D006943
MeSH_Definition: Abnormally high BLOOD GLUCOSE level.
MeSH_Name: Hyperglycemia
NUI: N0000001586
RxNorm_CUI: 1021913
SNOMED_CID: 80394007
UMLS_CUI: C0020456
code: C3350
imported from: NDF-RT.owl

Hyperkalemia [Disease/Finding]
type: Class
subclass of: Water-Electrolyte Imbalance [Disease/Finding]
Display_Name: Hyperkalemia
MeSH_CUI: M0010828
MeSH_DUI: D006947
MeSH_Definition: Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)
MeSH_Name: Hyperkalemia
NUI: N0000001590
RxNorm_CUI: 1021945
SNOMED_CID: 14140009
SNOMED_CID: 238142003
Synonym: Hyperpotassemia
UMLS_CUI: C0020461
code: C3358
imported from: NDF-RT.owl

Hypernatremia [Disease/Finding]
type: Class
subclass of: Water-Electrolyte Imbalance [Disease/Finding]
Display_Name: Hypernatremia
MeSH_CUI: M0010837
MeSH_DUI: D006955
MeSH_Definition: Excessive amount of sodium in the blood. (Dorland, 27th ed)
MeSH_Name: Hypernatremia
NUI: N0000001598
RxNorm_CUI: 1026718
SNOMED_CID: 286926003
SNOMED_CID: 39355002
UMLS_CUI: C0020488
code: C3374
imported from: NDF-RT.owl

Hypersensitivity [Disease/Finding]
type: Class
subclass of: Immune System Diseases [Disease/Finding]
Display_Name: Hypersensitivity
MeSH_CUI: M0010851
MeSH_DUI: D006967
MeSH_Definition: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
MeSH_Name: Hypersensitivity
NUI: N0000001610
RxNorm_CUI: 1022134
SNOMED_CID: 106190000
SNOMED_CID: 127072000
SNOMED_CID: 269284003
Synonym: Allergy
UMLS_CUI: C0020517
code: C3398
imported from: NDF-RT.owl

Hypersensitivity, Immediate [Disease/Finding]
type: Class
subclass of: Hypersensitivity [Disease/Finding]
Display_Name: Hypersensitivity, Immediate
MeSH_CUI: M0010854
MeSH_DUI: D006969
MeSH_Definition: Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
MeSH_Name: Hypersensitivity, Immediate
NUI: N0000001612
RxNorm_CUI: 1023968
SNOMED_CID: 20671006
Synonym: Atopic Hypersensitivity
Synonym: Hypersensitivity, Atopic
Synonym: Hypersensitivity, Type I
Synonym: IgE-Mediated Hypersensitivity
Synonym: Type I Hypersensitivity
UMLS_CUI: C0020523
code: C3402
imported from: NDF-RT.owl

Hypertension [Disease/Finding]
type: Class
subclass of: Vascular Diseases [Disease/Finding]
Display_Name: Hypertension
MeSH_CUI: M0010859
MeSH_DUI: D006973
MeSH_Definition: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
MeSH_Name: Hypertension
NUI: N0000001616
RxNorm_CUI: 1023354
SNOMED_CID: 38341003
Synonym: Blood Pressure, High
UMLS_CUI: C0020538
code: C3410
imported from: NDF-RT.owl

Hypocalcemia [Disease/Finding]
type: Class
subclass of: Calcium Metabolism Disorders [Disease/Finding]
subclass of: Water-Electrolyte Imbalance [Disease/Finding]
Display_Name: Hypocalcemia
MeSH_CUI: M0010891
MeSH_DUI: D006996
MeSH_Definition: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
MeSH_Name: Hypocalcemia
NUI: N0000001632
RxNorm_CUI: 1022560
SNOMED_CID: 5291005
UMLS_CUI: C0020598
code: C3442
imported from: NDF-RT.owl

Hypoglycemia [Disease/Finding]
type: Class
subclass of: Glucose Metabolism Disorders [Disease/Finding]
Display_Name: Hypoglycemia
MeSH_CUI: M0010901
MeSH_DUI: D007003
MeSH_Definition: A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
MeSH_Name: Hypoglycemia
NUI: N0000001635
RxNorm_CUI: 1026036
SNOMED_CID: 190433001
SNOMED_CID: 237630007
SNOMED_CID: 271327008
SNOMED_CID: 302866003
UMLS_CUI: C0020615
code: C3448
imported from: NDF-RT.owl

Hyponatremia [Disease/Finding]
type: Class
subclass of: Water-Electrolyte Imbalance [Disease/Finding]
Display_Name: Hyponatremia
MeSH_CUI: M0010911
MeSH_DUI: D007010
MeSH_Definition: Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
MeSH_Name: Hyponatremia
NUI: N0000001640
RxNorm_CUI: 1022083
SNOMED_CID: 238115004
SNOMED_CID: 89627008
UMLS_CUI: C0020625
code: C3458
imported from: NDF-RT.owl

Hypoprothrombinemias [Disease/Finding]
type: Class
subclass of: Hemorrhagic Disorders [Disease/Finding]
subclass of: Coagulation Protein Disorders [Disease/Finding]
subclass of: Blood Coagulation Disorders, Inherited [Disease/Finding]
Display_Name: Hypoprothrombinemias
MeSH_CUI: M0010925
MeSH_DUI: D007020
MeSH_Definition: Absence or reduced levels of prothrombin in the blood.
MeSH_Name: Hypoprothrombinemias
NUI: N0000001647
RxNorm_CUI: 1023756
SNOMED_CID: 73975000
Synonym: Deficiency, Factor II
Synonym: Factor II Deficiency
Synonym: Prothrombin Deficiency
UMLS_CUI: C0020640
code: C3472
imported from: NDF-RT.owl

Immunologic Deficiency Syndromes [Disease/Finding]
type: Class
subclass of: Immune System Diseases [Disease/Finding]
Display_Name: Immunologic Deficiency Syndromes
MeSH_CUI: M0011155
MeSH_DUI: D007153
MeSH_Definition: Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.
MeSH_Name: Immunologic Deficiency Syndromes
NUI: N0000001667
RxNorm_CUI: 1022772
SNOMED_CID: 191005003
SNOMED_CID: 234532001
Synonym: Deficiency Syndrome, Immunologic
Synonym: Deficiency Syndromes, Immunologic
Synonym: Immunologic Deficiency Syndrome
Synonym: Immunological Deficiency Syndromes
UMLS_CUI: C0021051
code: C3512
imported from: NDF-RT.owl

Immune System Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Immune System Diseases
MeSH_CUI: M0011156
MeSH_DUI: D007154
MeSH_Definition: Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.
MeSH_Name: Immune System Diseases
NUI: N0000001668
RxNorm_CUI: 1022843
SNOMED_CID: 41266007
Synonym: Diseases of Immune System
Synonym: Immune Diseases
Synonym: Immune Disorders
Synonym: Immunologic Diseases
Synonym: Immunological Diseases
UMLS_CUI: C0021053
code: C3514
imported from: NDF-RT.owl

Infant, Newborn, Diseases [Disease/Finding]
type: Class
subclass of: Congenital, Hereditary, and Neonatal Diseases and Abnormalities [Disease/Finding]
Display_Name: Infant, Newborn, Diseases
MeSH_CUI: M0011286
MeSH_DUI: D007232
MeSH_Definition: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.
MeSH_Name: Infant, Newborn, Diseases
NUI: N0000001678
RxNorm_CUI: 1024869
SNOMED_CID: 22925008
UMLS_CUI: C0021290
code: C3534
imported from: NDF-RT.owl

Infant, Premature, Diseases [Disease/Finding]
type: Class
subclass of: Infant, Newborn, Diseases [Disease/Finding]
Display_Name: Infant, Premature, Diseases
MeSH_CUI: M0011290
MeSH_DUI: D007235
MeSH_Name: Infant, Premature, Diseases
NUI: N0000001679
RxNorm_CUI: 990391
UMLS_CUI: C0021295
code: C3536
imported from: NDF-RT.owl

Infection [Disease/Finding]
type: Class
subclass of: Bacterial Infections and Mycoses [Disease/Finding]
Display_Name: Infection
MeSH_CUI: M0011294
MeSH_DUI: D007239
MeSH_Definition: Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.
MeSH_Name: Infection
NUI: N0000001681
RxNorm_CUI: 1022093
SNOMED_CID: 40733004
UMLS_CUI: C0021311
code: C3540
imported from: NDF-RT.owl

Intestinal Diseases [Disease/Finding]
type: Class
subclass of: Gastrointestinal Diseases [Disease/Finding]
Display_Name: Intestinal Diseases
MeSH_CUI: M0011569
MeSH_DUI: D007410
MeSH_Definition: Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.
MeSH_Name: Intestinal Diseases
NUI: N0000001698
RxNorm_CUI: 1023320
SNOMED_CID: 85919009
UMLS_CUI: C0021831
code: C3574
imported from: NDF-RT.owl

Kidney Calculi [Disease/Finding]
type: Class
subclass of: Urinary Calculi [Disease/Finding]
subclass of: Nephrolithiasis [Disease/Finding]
Display_Name: Kidney Calculi
MeSH_CUI: M0012008
MeSH_DUI: D007669
MeSH_Definition: Stones in the KIDNEY, usually formed in the urine-collecting area of the kidney (KIDNEY PELVIS). Their sizes vary and most contains CALCIUM OXALATE.
MeSH_Name: Kidney Calculi
NUI: N0000001746
RxNorm_CUI: 1022167
SNOMED_CID: 95570007
Synonym: Kidney Stones
Synonym: Renal Calculi
Synonym: Renal Calculus
UMLS_CUI: C0022650
code: C3670
imported from: NDF-RT.owl

Kidney Diseases [Disease/Finding]
type: Class
subclass of: Urologic Diseases [Disease/Finding]
Display_Name: Kidney Diseases
MeSH_CUI: M0012014
MeSH_DUI: D007674
MeSH_Definition: Pathological processes of the KIDNEY or its component tissues.
MeSH_Name: Kidney Diseases
NUI: N0000001748
RxNorm_CUI: 1022215
SNOMED_CID: 90708001
UMLS_CUI: C0022658
code: C3674
imported from: NDF-RT.owl

Kidney Failure, Acute [Disease/Finding]
type: Class
subclass of: Acute Kidney Injury [Disease/Finding]
Display_Name: Kidney Failure, Acute
MeSH_CUI: M0012015
MeSH_DUI: D058186
MeSH_Name: Kidney Failure, Acute
NUI: N0000001749
RxNorm_CUI: 1022586
SNOMED_CID: 14669001
Synonym: Acute Kidney Failure
Synonym: Acute Renal Failure
Synonym: Renal Failure, Acute
UMLS_CUI: C0022660
code: C3676
imported from: NDF-RT.owl

Kidney Failure, Chronic [Disease/Finding]
type: Class
subclass of: Renal Insufficiency, Chronic [Disease/Finding]
Display_Name: Kidney Failure, Chronic
MeSH_CUI: M0012016
MeSH_DUI: D007676
MeSH_Definition: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
MeSH_Name: Kidney Failure, Chronic
NUI: N0000001750
RxNorm_CUI: 988914
SNOMED_CID: 90688005
Synonym: Chronic Kidney Failure
Synonym: ESRD
Synonym: End-Stage Kidney Disease
Synonym: End-Stage Renal Disease
Synonym: Renal Disease, End-Stage
Synonym: Renal Failure, Chronic
Synonym: Renal Failure, End-Stage
UMLS_CUI: C0022661
code: C3678
imported from: NDF-RT.owl

Lacrimal Apparatus Diseases [Disease/Finding]
type: Class
subclass of: Eye Diseases [Disease/Finding]
Display_Name: Lacrimal Apparatus Diseases
MeSH_CUI: M0012135
MeSH_DUI: D007766
MeSH_Definition: Diseases of the lacrimal apparatus.
MeSH_Name: Lacrimal Apparatus Diseases
NUI: N0000001774
RxNorm_CUI: 1025659
SNOMED_CID: 31053003
UMLS_CUI: C0022904
code: C3726
imported from: NDF-RT.owl

Liver Cirrhosis [Disease/Finding]
type: Class
subclass of: Liver Diseases [Disease/Finding]
Display_Name: Liver Cirrhosis
MeSH_CUI: M0012636
MeSH_DUI: D008103
MeSH_Definition: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
MeSH_Name: Liver Cirrhosis
NUI: N0000001862
RxNorm_CUI: 1024193
SNOMED_CID: 19943007
Synonym: Cirrhosis, Liver
Synonym: Hepatic Cirrhosis
UMLS_CUI: C0023890
code: C3902
imported from: NDF-RT.owl

Liver Diseases [Disease/Finding]
type: Class
subclass of: Digestive System Diseases [Disease/Finding]
Display_Name: Liver Diseases
MeSH_CUI: M0012644
MeSH_DUI: D008107
MeSH_Definition: Pathological processes of the LIVER.
MeSH_Name: Liver Diseases
NUI: N0000001866
RxNorm_CUI: 1024220
SNOMED_CID: 235856003
UMLS_CUI: C0023895
code: C3910
imported from: NDF-RT.owl

Lung Diseases [Disease/Finding]
type: Class
subclass of: Respiratory Tract Diseases [Disease/Finding]
Display_Name: Lung Diseases
MeSH_CUI: M0012744
MeSH_DUI: D008171
MeSH_Definition: Pathological processes involving any part of the LUNG.
MeSH_Name: Lung Diseases
NUI: N0000001879
RxNorm_CUI: 1021971
SNOMED_CID: 19829001
Synonym: Disease, Pulmonary
Synonym: Diseases, Pulmonary
Synonym: Pulmonary Disease
Synonym: Pulmonary Diseases
UMLS_CUI: C0024115
code: C3936
imported from: NDF-RT.owl

Lung Neoplasms [Disease/Finding]
type: Class
subclass of: Lung Diseases [Disease/Finding]
subclass of: Respiratory Tract Neoplasms [Disease/Finding]
Display_Name: Lung Neoplasms
MeSH_CUI: M0012749
MeSH_DUI: D008175
MeSH_Definition: Tumors or cancer of the LUNG.
MeSH_Name: Lung Neoplasms
NUI: N0000001883
RxNorm_CUI: 1023224
SNOMED_CID: 126713003
Synonym: Neoplasms, Lung
Synonym: Neoplasms, Pulmonary
Synonym: Pulmonary Neoplasms
UMLS_CUI: C0024121
code: C3944
imported from: NDF-RT.owl

Magnesium Deficiency [Disease/Finding]
type: Class
subclass of: Deficiency Diseases [Disease/Finding]
Display_Name: Magnesium Deficiency
MeSH_CUI: M0012886
MeSH_DUI: D008275
MeSH_Definition: A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)
MeSH_Name: Magnesium Deficiency
NUI: N0000001921
RxNorm_CUI: 1024574
SNOMED_CID: 238118002
Synonym: Deficiency, Magnesium
UMLS_CUI: C0024473
code: C4020
imported from: NDF-RT.owl

Metabolic Diseases [Disease/Finding]
type: Class
subclass of: Nutritional and Metabolic Diseases [Disease/Finding]
Display_Name: Metabolic Diseases
MeSH_CUI: M0013493
MeSH_DUI: D008659
MeSH_Definition: Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
MeSH_Name: Metabolic Diseases
NUI: N0000002004
RxNorm_CUI: 1022778
SNOMED_CID: 30390004
SNOMED_CID: 75934005
Synonym: Diseases, Metabolic
Synonym: Thesaurismosis
UMLS_CUI: C0025517
code: C4186
imported from: NDF-RT.owl

Stomatognathic Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Stomatognathic Diseases
MeSH_CUI: M0014128
MeSH_DUI: D009057
MeSH_Definition: General or unspecified diseases of the stomatognathic system, comprising the mouth, teeth, jaws, and pharynx.
MeSH_Name: Stomatognathic Diseases
NUI: N0000002034
RxNorm_CUI: 1027350
Synonym: Mouth and Tooth Diseases
UMLS_CUI: C0038368
code: C4246
imported from: NDF-RT.owl

Mouth Diseases [Disease/Finding]
type: Class
subclass of: Stomatognathic Diseases [Disease/Finding]
Display_Name: Mouth Diseases
MeSH_CUI: M0014130
MeSH_DUI: D009059
MeSH_Name: Mouth Diseases
NUI: N0000002036
RxNorm_CUI: 1027441
SNOMED_CID: 118938008
UMLS_CUI: C0026636
code: C4250
imported from: NDF-RT.owl

Muscle Hypotonia [Disease/Finding]
type: Class
subclass of: Neuromuscular Manifestations [Disease/Finding]
Display_Name: Muscle Hypotonia
MeSH_CUI: M0014238
MeSH_DUI: D009123
MeSH_Definition: A diminution of the skeletal muscle tone marked by a diminished resistance to passive stretching.
MeSH_Name: Muscle Hypotonia
NUI: N0000002059
RxNorm_CUI: 1024653
SNOMED_CID: 398151007
SNOMED_CID: 398152000
Synonym: Decreased Muscle Tone
Synonym: Hypomyotonia
Synonym: Hypotonia
Synonym: Hypotony, Muscle
Synonym: Muscle Tone Poor
Synonym: Muscular Hypotonia
UMLS_CUI: C0026827
code: C4296
imported from: NDF-RT.owl

Musculoskeletal Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Musculoskeletal Diseases
MeSH_CUI: M0014259
MeSH_DUI: D009140
MeSH_Definition: Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.
MeSH_Name: Musculoskeletal Diseases
NUI: N0000002067
RxNorm_CUI: 1022076
SNOMED_CID: 928000
UMLS_CUI: C0026857
code: C4312
imported from: NDF-RT.owl

Mycoses [Disease/Finding]
type: Class
subclass of: Bacterial Infections and Mycoses [Disease/Finding]
Display_Name: Mycoses
MeSH_CUI: M0014313
MeSH_DUI: D009181
MeSH_Name: Mycoses
NUI: N0000002075
RxNorm_CUI: 1024676
SNOMED_CID: 3218000
Synonym: Fungus Diseases
UMLS_CUI: C0026946
code: C4328
imported from: NDF-RT.owl

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH_CUI: M0014570
MeSH_DUI: D009358
MeSH_Definition: Diseases existing at birth and often before birth, or that develop during the first month of life (INFANT, NEWBORN, DISEASES), regardless of causation. Of these diseases, those characterized by structural deformities are termed CONGENITAL ABNORMALITIES.
MeSH_Name: Congenital, Hereditary, and Neonatal Diseases and Abnormalities
NUI: N0000002121
RxNorm_CUI: 989203
UMLS_CUI: C0027612
code: C4420
imported from: NDF-RT.owl

Neoplasms [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Neoplasms
MeSH_CUI: M0014585
MeSH_DUI: D009369
MeSH_Definition: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
MeSH_Name: Neoplasms
NUI: N0000002128
RxNorm_CUI: 1022284
SNOMED_CID: 189525008
SNOMED_CID: 189526009
SNOMED_CID: 55342001
Synonym: Tumors
UMLS_CUI: C0027651
code: C4434
imported from: NDF-RT.owl

Neoplasms by Histologic Type [Disease/Finding]
type: Class
subclass of: Neoplasms [Disease/Finding]
Display_Name: Neoplasms by Histologic Type
MeSH_CUI: M0014588
MeSH_DUI: D009370
MeSH_Definition: A collective term for the various histological types of NEOPLASMS. It is more likely to be used by searchers than by indexers and catalogers.
MeSH_Name: Neoplasms by Histologic Type
NUI: N0000002129
RxNorm_CUI: 986146
Synonym: Histological Type of Neoplasm
Synonym: Histological Types of Neoplasms
Synonym: Neoplasms by Histological Type
UMLS_CUI: C0027652
code: C4436
imported from: NDF-RT.owl

Neoplasms by Site [Disease/Finding]
type: Class
subclass of: Neoplasms [Disease/Finding]
Display_Name: Neoplasms by Site
MeSH_CUI: M0014589
MeSH_DUI: D009371
MeSH_Definition: A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS; DUODENAL NEOPLASMS; LIVER NEOPLASMS; etc.
MeSH_Name: Neoplasms by Site
NUI: N0000002130
RxNorm_CUI: 1026659
Synonym: Neoplasms by Sites
Synonym: Site, Neoplasm
Synonym: Sites, Neoplasm
UMLS_CUI: C0027653
code: C4438
imported from: NDF-RT.owl

Neoplasms, Germ Cell and Embryonal [Disease/Finding]
type: Class
subclass of: Neoplasms by Histologic Type [Disease/Finding]
Display_Name: Neoplasms, Germ Cell and Embryonal
MeSH_CUI: M0014592
MeSH_DUI: D009373
MeSH_Definition: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
MeSH_Name: Neoplasms, Germ Cell and Embryonal
NUI: N0000002132
RxNorm_CUI: 1026873
Synonym: Germ Cell and Embryonal Neoplasms
Synonym: Germ Cell and Embryonic Neoplasms
Synonym: Neoplasms, Germ Cell and Embryonic
UMLS_CUI: C0027658
code: C4442
imported from: NDF-RT.owl

Neoplasms, Nerve Tissue [Disease/Finding]
type: Class
subclass of: Neoplasms by Histologic Type [Disease/Finding]
Display_Name: Neoplasms, Nerve Tissue
MeSH_CUI: M0014605
MeSH_DUI: D009380
MeSH_Definition: Neoplasms composed of nerve tissue. This concept does not refer to neoplasms located in the nervous system or its component nerves.
MeSH_Name: Neoplasms, Nerve Tissue
NUI: N0000002139
RxNorm_CUI: 985772
Synonym: Neoplasms, Nervous Tissue
Synonym: Nerve Tissue Neoplasms
Synonym: Nervous Tissue Neoplasms
UMLS_CUI: C0027665
code: C4456
imported from: NDF-RT.owl

Nephrosis [Disease/Finding]
type: Class
subclass of: Kidney Diseases [Disease/Finding]
Display_Name: Nephrosis
MeSH_CUI: M0014635
MeSH_DUI: D009401
MeSH_Definition: Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.
MeSH_Name: Nephrosis
NUI: N0000002153
RxNorm_CUI: 1025384
SNOMED_CID: 90708001
UMLS_CUI: C0027720
code: C4484
imported from: NDF-RT.owl

Nephrotic Syndrome [Disease/Finding]
type: Class
subclass of: Nephrosis [Disease/Finding]
Display_Name: Nephrotic Syndrome
MeSH_CUI: M0014639
MeSH_DUI: D009404
MeSH_Definition: A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
MeSH_Name: Nephrotic Syndrome
NUI: N0000002155
RxNorm_CUI: 1026285
SNOMED_CID: 52254009
UMLS_CUI: C0027726
code: C4488
imported from: NDF-RT.owl

Nervous System Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Nervous System Diseases
MeSH_CUI: M0014667
MeSH_DUI: D009422
MeSH_Definition: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
MeSH_Name: Nervous System Diseases
NUI: N0000002159
RxNorm_CUI: 1026444
SNOMED_CID: 118940003
Synonym: Nervous System Disorders
Synonym: Neurologic Disorders
Synonym: Neurological Disorders
UMLS_CUI: C0027765
code: C4496
imported from: NDF-RT.owl

Neurologic Manifestations [Disease/Finding]
type: Class
subclass of: Nervous System Diseases [Disease/Finding]
subclass of: Signs and Symptoms [Disease/Finding]
Display_Name: Neurologic Manifestations
MeSH_CUI: M0014716
MeSH_DUI: D009461
MeSH_Definition: Clinical signs and symptoms caused by nervous system injury or dysfunction.
MeSH_Name: Neurologic Manifestations
NUI: N0000002173
RxNorm_CUI: 1025946
Synonym: Manifestations, Neurologic
Synonym: Manifestations, Neurological
Synonym: Neurologic Manifestation
Synonym: Neurologic Signs and Symptoms
Synonym: Neurological Manifestations
UMLS_CUI: C0027854
code: C4524
imported from: NDF-RT.owl

Nutrition Disorders [Disease/Finding]
type: Class
subclass of: Nutritional and Metabolic Diseases [Disease/Finding]
Display_Name: Nutrition Disorders
MeSH_CUI: M0015120
MeSH_DUI: D009748
MeSH_Definition: Disorders caused by nutritional imbalance, either overnutrition or undernutrition.
MeSH_Name: Nutrition Disorders
NUI: N0000002196
RxNorm_CUI: 1024039
SNOMED_CID: 2492009
Synonym: Nutritional Disorders
UMLS_CUI: C0028709
code: C4570
imported from: NDF-RT.owl

Nutritional and Metabolic Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Nutritional and Metabolic Diseases
MeSH_CUI: M0015124
MeSH_DUI: D009750
MeSH_Definition: A collective term for nutritional disorders resulting from poor absorption or nutritional imbalance, and metabolic disorders resulting from defects in biosynthesis (ANABOLISM) or breakdown (CATABOLISM) of endogenous substances.
MeSH_Name: Nutritional and Metabolic Diseases
NUI: N0000002197
RxNorm_CUI: 1026553
UMLS_CUI: C0028715
code: C4572
imported from: NDF-RT.owl

Opportunistic Infections [Disease/Finding]
type: Class
subclass of: Infection [Disease/Finding]
subclass of: Parasitic Diseases [Disease/Finding]
subclass of: Virus Diseases [Disease/Finding]
Display_Name: Opportunistic Infections
MeSH_CUI: M0015350
MeSH_DUI: D009894
MeSH_Definition: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
MeSH_Name: Opportunistic Infections
NUI: N0000002225
RxNorm_CUI: 1025670
SNOMED_CID: 61274003
UMLS_CUI: C0029118
code: C4628
imported from: NDF-RT.owl

Osteoporosis [Disease/Finding]
type: Class
subclass of: Bone Diseases, Metabolic [Disease/Finding]
Display_Name: Osteoporosis
MeSH_CUI: M0015552
MeSH_DUI: D010024
MeSH_Definition: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
MeSH_Name: Osteoporosis
NUI: N0000002260
RxNorm_CUI: 1022418
SNOMED_CID: 203428004
SNOMED_CID: 64859006
UMLS_CUI: C0029456
code: C4698
imported from: NDF-RT.owl

Paraganglioma [Disease/Finding]
type: Class
subclass of: Neuroendocrine Tumors [Disease/Finding]
Display_Name: Paraganglioma
MeSH_CUI: M0015869
MeSH_DUI: D010235
MeSH_Definition: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992)
MeSH_Name: Paraganglioma
NUI: N0000002299
RxNorm_CUI: 1022619
SNOMED_CID: 127027008
SNOMED_CID: 253029009
SNOMED_CID: 302833002
Synonym: Paraganglioma, Gangliocytic
UMLS_CUI: C0030421
code: C4776
imported from: NDF-RT.owl

Parasitic Diseases [Disease/Finding]
type: Class
subclass of: Infectious Diseases [Disease/Finding]
Display_Name: Parasitic Diseases
MeSH_CUI: M0015919
MeSH_DUI: D010272
MeSH_Definition: Infections or infestations with parasitic organisms. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.
MeSH_Name: Parasitic Diseases
NUI: N0000002319
RxNorm_CUI: 987316
SNOMED_CID: 17322007
UMLS_CUI: C0030499
code: C4816
imported from: NDF-RT.owl

Pathologic Processes [Disease/Finding]
type: Class
subclass of: Pathological Conditions, Signs and Symptoms [Disease/Finding]
Display_Name: Pathologic Processes
MeSH_CUI: M0016012
MeSH_DUI: D010335
MeSH_Definition: The abnormal mechanisms and forms involved in the dysfunctions of tissues and organs.
MeSH_Name: Pathologic Processes
NUI: N0000002338
RxNorm_CUI: 1025320
SNOMED_CID: 308489006
SNOMED_CID: 370135005
Synonym: Pathological Processes
Synonym: Processes, Pathologic
UMLS_CUI: C0030660
code: C4854
imported from: NDF-RT.owl

Pheochromocytoma [Disease/Finding]
type: Class
subclass of: Paraganglioma [Disease/Finding]
Display_Name: Pheochromocytoma
MeSH_CUI: M0016586
MeSH_DUI: D010673
MeSH_Definition: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
MeSH_Name: Pheochromocytoma
NUI: N0000002390
RxNorm_CUI: 1021872
SNOMED_CID: 302835009
SNOMED_CID: 399343007
UMLS_CUI: C0031511
code: C4958
imported from: NDF-RT.owl

Poisoning [Disease/Finding]
type: Class
subclass of: Substance-Related Disorders [Disease/Finding]
Display_Name: Poisoning
MeSH_CUI: M0017099
MeSH_DUI: D011041
MeSH_Definition: A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.
MeSH_Name: Poisoning
NUI: N0000002447
RxNorm_CUI: 1026915
SNOMED_CID: 75478009
UMLS_CUI: C0032343
code: C5072
imported from: NDF-RT.owl

Postoperative Complications [Disease/Finding]
type: Class
subclass of: Pathologic Processes [Disease/Finding]
Display_Name: Postoperative Complications
MeSH_CUI: M0017367
MeSH_DUI: D011183
MeSH_Definition: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
MeSH_Name: Postoperative Complications
NUI: N0000002467
RxNorm_CUI: 1022600
SNOMED_CID: 385486001
Synonym: Complication, Postoperative
UMLS_CUI: C0032787
code: C5112
imported from: NDF-RT.owl

Psoriasis [Disease/Finding]
type: Class
subclass of: Skin Diseases, Papulosquamous [Disease/Finding]
Display_Name: Psoriasis
MeSH_CUI: M0017975
MeSH_DUI: D011565
MeSH_Definition: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
MeSH_Name: Psoriasis
NUI: N0000002526
RxNorm_CUI: 1022582
SNOMED_CID: 200961000
SNOMED_CID: 9014002
UMLS_CUI: C0033860
code: C5230
imported from: NDF-RT.owl

Pulmonary Edema [Disease/Finding]
type: Class
subclass of: Lung Diseases [Disease/Finding]
Display_Name: Pulmonary Edema
MeSH_CUI: M0018125
MeSH_DUI: D011654
MeSH_Definition: Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
MeSH_Name: Pulmonary Edema
NUI: N0000002540
RxNorm_CUI: 1024136
SNOMED_CID: 19242006
Synonym: Edema, Pulmonary
Synonym: Edemas, Pulmonary
Synonym: Pulmonary Edemas
Synonym: Wet Lung
UMLS_CUI: C0034063
code: C5258
imported from: NDF-RT.owl

Respiratory Tract Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Respiratory Tract Diseases
MeSH_CUI: M0018918
MeSH_DUI: D012140
MeSH_Name: Respiratory Tract Diseases
NUI: N0000002602
RxNorm_CUI: 1024163
UMLS_CUI: C0035242
code: C5382
imported from: NDF-RT.owl

Respiratory Tract Neoplasms [Disease/Finding]
type: Class
subclass of: Respiratory Tract Diseases [Disease/Finding]
subclass of: Thoracic Neoplasms [Disease/Finding]
Display_Name: Respiratory Tract Neoplasms
MeSH_CUI: M0018921
MeSH_DUI: D012142
MeSH_Name: Respiratory Tract Neoplasms
NUI: N0000002604
RxNorm_CUI: 986366
SNOMED_CID: 126667002
UMLS_CUI: C0035244
code: C5386
imported from: NDF-RT.owl

Retroviridae Infections [Disease/Finding]
type: Class
subclass of: RNA Virus Infections [Disease/Finding]
Display_Name: Retroviridae Infections
MeSH_CUI: M0018986
MeSH_DUI: D012192
MeSH_Definition: Virus diseases caused by the RETROVIRIDAE.
MeSH_Name: Retroviridae Infections
NUI: N0000002623
RxNorm_CUI: 1025440
SNOMED_CID: 105635000
Synonym: Infections, Retroviridae
Synonym: Infections, Retrovirus
Synonym: Retrovirus Infections
UMLS_CUI: C0035369
code: C5424
imported from: NDF-RT.owl

RNA Virus Infections [Disease/Finding]
type: Class
subclass of: Virus Diseases [Disease/Finding]
Display_Name: RNA Virus Infections
MeSH_CUI: M0019160
MeSH_DUI: D012327
MeSH_Name: RNA Virus Infections
NUI: N0000002650
RxNorm_CUI: 1027571
Synonym: Infections, RNA Virus
UMLS_CUI: C0035690
code: C5478
imported from: NDF-RT.owl

Sexually Transmitted Diseases [Disease/Finding]
type: Class
subclass of: Genital Diseases, Female [Disease/Finding]
subclass of: Genital Diseases, Male [Disease/Finding]
subclass of: Infection [Disease/Finding]
subclass of: Virus Diseases [Disease/Finding]
Display_Name: Sexually Transmitted Diseases
MeSH_CUI: M0019758
MeSH_DUI: D012749
MeSH_Definition: Diseases due to or propagated by sexual contact.
MeSH_Name: Sexually Transmitted Diseases
NUI: N0000002724
RxNorm_CUI: 1023328
SNOMED_CID: 8098009
Synonym: STDs
Synonym: Venereal Diseases
UMLS_CUI: C0036916
code: C5626
imported from: NDF-RT.owl

Shock [Disease/Finding]
type: Class
subclass of: Pathologic Processes [Disease/Finding]
Display_Name: Shock
MeSH_CUI: M0019782
MeSH_DUI: D012769
MeSH_Definition: A pathological condition manifested by failure to perfuse or oxygenate vital organs.
MeSH_Name: Shock
NUI: N0000002728
RxNorm_CUI: 1023333
SNOMED_CID: 274729009
SNOMED_CID: 27942005
Synonym: Circulatory Collapse
Synonym: Circulatory Failure
UMLS_CUI: C0036974
code: C5634
imported from: NDF-RT.owl

Shock, Hemorrhagic [Disease/Finding]
type: Class
subclass of: Hemorrhage [Disease/Finding]
subclass of: Shock [Disease/Finding]
Display_Name: Shock, Hemorrhagic
MeSH_CUI: M0019784
MeSH_DUI: D012771
MeSH_Definition: Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
MeSH_Name: Shock, Hemorrhagic
NUI: N0000002730
RxNorm_CUI: 1026764
SNOMED_CID: 355001
Synonym: Hemorrhagic Shock
UMLS_CUI: C0036982
code: C5638
imported from: NDF-RT.owl

Signs and Symptoms [Disease/Finding]
type: Class
subclass of: Pathological Conditions, Signs and Symptoms [Disease/Finding]
Display_Name: Signs and Symptoms
MeSH_CUI: M0019845
MeSH_DUI: D012816
MeSH_Definition: Clinical manifestations that can be either objective when observed by a physician, or subjective when perceived by the patient.
MeSH_Name: Signs and Symptoms
NUI: N0000002748
RxNorm_CUI: 1024593
UMLS_CUI: C0037088
code: C5674
imported from: NDF-RT.owl

Skin Diseases [Disease/Finding]
type: Class
subclass of: Skin and Connective Tissue Diseases [Disease/Finding]
Display_Name: Skin Diseases
MeSH_CUI: M0019929
MeSH_DUI: D012871
MeSH_Name: Skin Diseases
NUI: N0000002761
RxNorm_CUI: 1022858
SNOMED_CID: 95320005
Synonym: Dermatoses
Synonym: Dermatosis
UMLS_CUI: C0037274
code: C5700
imported from: NDF-RT.owl

Skin Diseases, Genetic [Disease/Finding]
type: Class
subclass of: Skin Diseases [Disease/Finding]
subclass of: Genetic Diseases, Inborn [Disease/Finding]
Display_Name: Skin Diseases, Genetic
MeSH_CUI: M0019934
MeSH_DUI: D012873
MeSH_Definition: Diseases of the skin with a genetic component, usually the result of various inborn errors of metabolism.
MeSH_Name: Skin Diseases, Genetic
NUI: N0000002763
RxNorm_CUI: 986094
SNOMED_CID: 239001006
Synonym: Genetic Skin Diseases
UMLS_CUI: C0037277
code: C5704
imported from: NDF-RT.owl

Skin Diseases, Infectious [Disease/Finding]
type: Class
subclass of: Infection [Disease/Finding]
subclass of: Skin Diseases [Disease/Finding]
Display_Name: Skin Diseases, Infectious
MeSH_CUI: M0019935
MeSH_DUI: D012874
MeSH_Definition: Skin diseases caused by bacteria, fungi, parasites, or viruses.
MeSH_Name: Skin Diseases, Infectious
NUI: N0000002764
RxNorm_CUI: 1025346
SNOMED_CID: 108365000
Synonym: Infectious Skin Diseases
UMLS_CUI: C0037278
code: C5706
imported from: NDF-RT.owl

Skin Neoplasms [Disease/Finding]
type: Class
subclass of: Neoplasms by Site [Disease/Finding]
subclass of: Skin Diseases [Disease/Finding]
Display_Name: Skin Neoplasms
MeSH_CUI: M0019939
MeSH_DUI: D012878
MeSH_Definition: Tumors or cancer of the SKIN.
MeSH_Name: Skin Neoplasms
NUI: N0000002768
RxNorm_CUI: 1025991
SNOMED_CID: 126488004
Synonym: Neoplasms, Skin
UMLS_CUI: C0037286
code: C5714
imported from: NDF-RT.owl

Substance Withdrawal Syndrome [Disease/Finding]
type: Class
subclass of: Substance-Related Disorders [Disease/Finding]
Display_Name: Substance Withdrawal Syndrome
MeSH_CUI: M0020676
MeSH_DUI: D013375
MeSH_Definition: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
MeSH_Name: Substance Withdrawal Syndrome
NUI: N0000002855
RxNorm_CUI: 1027256
UMLS_CUI: C0038587
code: C5888
imported from: NDF-RT.owl

Pathological Conditions, Signs and Symptoms [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Pathological Conditions, Signs and Symptoms
MeSH_CUI: M0020949
MeSH_DUI: D013568
MeSH_Definition: Abnormal anatomical or physiological conditions and objective or subjective manifestations of disease, not classified as disease or syndrome.
MeSH_Name: Pathological Conditions, Signs and Symptoms
NUI: N0000002872
RxNorm_CUI: 984268
Synonym: Symptoms and General Pathology
UMLS_CUI: C0039058
code: C5922
imported from: NDF-RT.owl

Tetany [Disease/Finding]
type: Class
subclass of: Hypocalcemia [Disease/Finding]
subclass of: Neuromuscular Manifestations [Disease/Finding]
Display_Name: Tetany
MeSH_CUI: M0021207
MeSH_DUI: D013746
MeSH_Definition: A disorder characterized by muscle twitches, cramps, and carpopedal spasm, and when severe, laryngospasm and seizures. This condition is associated with unstable depolarization of axonal membranes, primarily in the peripheral nervous system. Tetany usually results from HYPOCALCEMIA or reduced serum levels of MAGNESIUM that may be associated with HYPERVENTILATION; HYPOPARATHYROIDISM; RICKETS; UREMIA; or other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1490)
MeSH_Name: Tetany
NUI: N0000002916
RxNorm_CUI: 1024300
SNOMED_CID: 10629009
UMLS_CUI: C0039621
code: C6010
imported from: NDF-RT.owl

Thoracic Neoplasms [Disease/Finding]
type: Class
subclass of: Neoplasms by Site [Disease/Finding]
Display_Name: Thoracic Neoplasms
MeSH_CUI: M0021397
MeSH_DUI: D013899
MeSH_Name: Thoracic Neoplasms
NUI: N0000002927
RxNorm_CUI: 1029082
SNOMED_CID: 255058005
UMLS_CUI: C0039981
code: C6032
imported from: NDF-RT.owl

Unconsciousness [Disease/Finding]
type: Class
subclass of: Consciousness Disorders [Disease/Finding]
Display_Name: Unconsciousness
MeSH_CUI: M0022251
MeSH_DUI: D014474
MeSH_Definition: Loss of the ability to maintain awareness of self and environment combined with markedly reduced responsiveness to environmental stimuli. (From Adams et al., Principles of Neurology, 6th ed, pp344-5)
MeSH_Name: Unconsciousness
NUI: N0000003064
RxNorm_CUI: 1026031
SNOMED_CID: 418107008
SNOMED_CID: 419045004
Synonym: Consciousness, Loss of
Synonym: Unconscious State
UMLS_CUI: C0041657
code: C6306
imported from: NDF-RT.owl

Urinary Calculi [Disease/Finding]
type: Class
subclass of: Calculi [Disease/Finding]
subclass of: Urolithiasis [Disease/Finding]
Display_Name: Urinary Calculi
MeSH_CUI: M0022362
MeSH_DUI: D014545
MeSH_Definition: Low-density crystals or stones in any part of the URINARY TRACT. Their chemical compositions often include CALCIUM OXALATE, magnesium ammonium phosphate (struvite), CYSTINE, or URIC ACID.
MeSH_Name: Urinary Calculi
NUI: N0000003077
RxNorm_CUI: 1023616
SNOMED_CID: 197797001
Synonym: Urinary Stones
Synonym: Urinary Tract Stones
UMLS_CUI: C0042018
code: C6332
imported from: NDF-RT.owl

Urination Disorders [Disease/Finding]
type: Class
subclass of: Urologic Diseases [Disease/Finding]
Display_Name: Urination Disorders
MeSH_CUI: M0022377
MeSH_DUI: D014555
MeSH_Definition: Abnormalities in the process of URINE voiding, including bladder control, frequency of URINATION, as well as the volume and composition of URINE.
MeSH_Name: Urination Disorders
NUI: N0000003082
RxNorm_CUI: 1025163
UMLS_CUI: C0042035
code: C6342
imported from: NDF-RT.owl

Male Urogenital Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Male Urogenital Diseases
MeSH_CUI: M0489510
MeSH_DUI: D052801
MeSH_Definition: Pathological processes of the male URINARY TRACT and the reproductive system (GENITALIA, MALE).
MeSH_Name: Male Urogenital Diseases
NUI: N0000003085
RxNorm_CUI: 1027597
Synonym: Male Genitourinary Diseases
UMLS_CUI: C1720894
code: CMSHM0489510
imported from: NDF-RT.owl

Urologic Diseases [Disease/Finding]
type: Class
subclass of: Male Urogenital Diseases [Disease/Finding]
subclass of: Female Urogenital Diseases [Disease/Finding]
Display_Name: Urologic Diseases
MeSH_CUI: M0022400
MeSH_DUI: D014570
MeSH_Definition: Pathological processes of the URINARY TRACT in both males and females.
MeSH_Name: Urologic Diseases
NUI: N0000003086
RxNorm_CUI: 1022769
SNOMED_CID: 128606002
SNOMED_CID: 197951006
SNOMED_CID: 41368006
Synonym: Urinary Tract Diseases
Synonym: Urological Diseases
UMLS_CUI: C0042075
code: C6350
imported from: NDF-RT.owl

Vaginal Diseases [Disease/Finding]
type: Class
subclass of: Genital Diseases, Female [Disease/Finding]
Display_Name: Vaginal Diseases
MeSH_CUI: M0022482
MeSH_DUI: D014623
MeSH_Definition: Pathological processes of the VAGINA.
MeSH_Name: Vaginal Diseases
NUI: N0000003104
RxNorm_CUI: 1026314
SNOMED_CID: 25658005
UMLS_CUI: C0042251
code: C6386
imported from: NDF-RT.owl

Vaginitis [Disease/Finding]
type: Class
subclass of: Vaginal Diseases [Disease/Finding]
Display_Name: Vaginitis
MeSH_CUI: M0022488
MeSH_DUI: D014627
MeSH_Definition: Inflammation of the vagina characterized by pain and a purulent discharge.
MeSH_Name: Vaginitis
NUI: N0000003107
RxNorm_CUI: 1021851
SNOMED_CID: 198213001
SNOMED_CID: 30800001
UMLS_CUI: C0042267
code: C6392
imported from: NDF-RT.owl

Vascular Diseases [Disease/Finding]
type: Class
subclass of: Cardiovascular Diseases [Disease/Finding]
Display_Name: Vascular Diseases
MeSH_CUI: M0022535
MeSH_DUI: D014652
MeSH_Definition: Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
MeSH_Name: Vascular Diseases
NUI: N0000003111
RxNorm_CUI: 1024109
SNOMED_CID: 27550009
UMLS_CUI: C0042373
code: C6400
imported from: NDF-RT.owl

Ventricular Fibrillation [Disease/Finding]
type: Class
subclass of: Arrhythmias, Cardiac [Disease/Finding]
Display_Name: Ventricular Fibrillation
MeSH_CUI: M0022595
MeSH_DUI: D014693
MeSH_Definition: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
MeSH_Name: Ventricular Fibrillation
NUI: N0000003118
RxNorm_CUI: 1024218
SNOMED_CID: 71908006
UMLS_CUI: C0042510
code: C6414
imported from: NDF-RT.owl

Ventricular Outflow Obstruction [Disease/Finding]
type: Class
subclass of: Heart Diseases [Disease/Finding]
Display_Name: Ventricular Outflow Obstruction
MeSH_CUI: M0022598
MeSH_DUI: D014694
MeSH_Definition: Occlusion of the outflow tract in either the LEFT VENTRICLE or the RIGHT VENTRICLE of the heart. This may result from CONGENITAL HEART DEFECTS, predisposing heart diseases, complications of surgery, or HEART NEOPLASMS.
MeSH_Name: Ventricular Outflow Obstruction
NUI: N0000003119
RxNorm_CUI: 1028258
UMLS_CUI: C0042512
code: C6416
imported from: NDF-RT.owl

Virus Diseases [Disease/Finding]
type: Class
subclass of: Infectious Diseases [Disease/Finding]
Display_Name: Virus Diseases
MeSH_CUI: M0022758
MeSH_DUI: D014777
MeSH_Definition: A general term for diseases produced by viruses.
MeSH_Name: Virus Diseases
NUI: N0000003128
RxNorm_CUI: 1022696
SNOMED_CID: 34014006
Synonym: Viral Diseases
UMLS_CUI: C0042769
code: C6434
imported from: NDF-RT.owl

Vulvar Diseases [Disease/Finding]
type: Class
subclass of: Genital Diseases, Female [Disease/Finding]
Display_Name: Vulvar Diseases
MeSH_CUI: M0022856
MeSH_DUI: D014845
MeSH_Definition: Pathological processes of the VULVA.
MeSH_Name: Vulvar Diseases
NUI: N0000003145
RxNorm_CUI: 1024723
SNOMED_CID: 5089007
UMLS_CUI: C0042994
code: C6468
imported from: NDF-RT.owl

Vulvitis [Disease/Finding]
type: Class
subclass of: Vulvar Diseases [Disease/Finding]
Display_Name: Vulvitis
MeSH_CUI: M0022858
MeSH_DUI: D014847
MeSH_Definition: Inflammation of the VULVA. It is characterized by PRURITUS and painful urination.
MeSH_Name: Vulvitis
NUI: N0000003147
RxNorm_CUI: 1023099
SNOMED_CID: 266586003
SNOMED_CID: 63144007
UMLS_CUI: C0042996
code: C6472
imported from: NDF-RT.owl

Vulvovaginitis [Disease/Finding]
type: Class
subclass of: Vaginitis [Disease/Finding]
subclass of: Vulvitis [Disease/Finding]
Display_Name: Vulvovaginitis
MeSH_CUI: M0022859
MeSH_DUI: D014848
MeSH_Definition: Inflammation of the VULVA and the VAGINA, characterized by discharge, burning, and PRURITUS.
MeSH_Name: Vulvovaginitis
NUI: N0000003148
RxNorm_CUI: 1025805
SNOMED_CID: 198215008
SNOMED_CID: 53277000
UMLS_CUI: C0042998
code: C6474
imported from: NDF-RT.owl

Water-Electrolyte Imbalance [Disease/Finding]
type: Class
subclass of: Metabolic Diseases [Disease/Finding]
Display_Name: Water-Electrolyte Imbalance
MeSH_CUI: M0022901
MeSH_DUI: D014883
MeSH_Definition: Disturbances in the body's WATER-ELECTROLYTE BALANCE.
MeSH_Name: Water-Electrolyte Imbalance
NUI: N0000003154
RxNorm_CUI: 1028873
UMLS_CUI: C0043065
code: C6486
imported from: NDF-RT.owl

Wounds and Injuries [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Wounds and Injuries
MeSH_CUI: M0023019
MeSH_DUI: D014947
MeSH_Definition: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
MeSH_Name: Wounds and Injuries
NUI: N0000003169
RxNorm_CUI: 1022221
SNOMED_CID: 19130008
Synonym: Injuries and Wounds
Synonym: Injuries, Wounds
Synonym: Trauma
Synonym: Wounds and Injury
Synonym: Wounds, Injury
UMLS_CUI: C0043251
code: C6516
imported from: NDF-RT.owl

Inflammatory Bowel Diseases [Disease/Finding]
type: Class
subclass of: Gastroenteritis [Disease/Finding]
subclass of: Intestinal Diseases [Disease/Finding]
Display_Name: Inflammatory Bowel Diseases
MeSH_CUI: M0023374
MeSH_DUI: D015212
MeSH_Definition: Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.
MeSH_Name: Inflammatory Bowel Diseases
NUI: N0000003206
RxNorm_CUI: 1023128
SNOMED_CID: 24526004
Synonym: Bowel Diseases, Inflammatory
UMLS_CUI: C0021390
code: C6590
imported from: NDF-RT.owl

Sexually Transmitted Diseases, Viral [Disease/Finding]
type: Class
subclass of: Sexually Transmitted Diseases [Disease/Finding]
Display_Name: Sexually Transmitted Diseases, Viral
MeSH_CUI: M0023402
MeSH_DUI: D015229
MeSH_Definition: Viral diseases which are transmitted or propagated by sexual conduct.
MeSH_Name: Sexually Transmitted Diseases, Viral
NUI: N0000003211
RxNorm_CUI: 1027279
Synonym: Sexually Transmitted Disease, Viral
Synonym: Venereal Diseases, Viral
Synonym: Viral Sexually Transmitted Disease
Synonym: Viral Sexually Transmitted Diseases
Synonym: Viral Venereal Diseases
UMLS_CUI: C0036918
code: C6600
imported from: NDF-RT.owl

Dry Eye Syndromes [Disease/Finding]
type: Class
subclass of: Lacrimal Apparatus Diseases [Disease/Finding]
Display_Name: Dry Eye Syndromes
MeSH_CUI: M0023637
MeSH_DUI: D015352
MeSH_Definition: Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
MeSH_Name: Dry Eye Syndromes
NUI: N0000003223
RxNorm_CUI: 987360
SNOMED_CID: 46152009
UMLS_CUI: C0013238
code: C6624
imported from: NDF-RT.owl

Overdose [Disease/Finding]
type: Class
subclass of: Poisoning [Disease/Finding]
Display_Name: Overdose
MeSH_CUI: M0023903
MeSH_DUI: D015537
MeSH_Definition: An accidental or deliberate dose of a medication or street drug that is in excess of what is normally used.
MeSH_Name: Overdose
NUI: N0000003288
RxNorm_CUI: 1023841
SNOMED_CID: 55680006
UMLS_CUI: C0029944
code: C6754
imported from: NDF-RT.owl

HIV Infections [Disease/Finding]
type: Class
subclass of: Immunologic Deficiency Syndromes [Disease/Finding]
subclass of: Sexually Transmitted Diseases, Viral [Disease/Finding]
subclass of: Lentivirus Infections [Disease/Finding]
Display_Name: HIV Infections
MeSH_CUI: M0023997
MeSH_DUI: D015658
MeSH_Definition: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
MeSH_Name: HIV Infections
NUI: N0000003302
RxNorm_CUI: 1022756
SNOMED_CID: 86406008
Synonym: HTLV-III Infections
Synonym: HTLV-III-LAV Infections
Synonym: T-Lymphotropic Virus Type III Infections, Human
UMLS_CUI: C0019693
code: C6782
imported from: NDF-RT.owl

Corneal Edema [Disease/Finding]
type: Class
subclass of: Corneal Diseases [Disease/Finding]
Display_Name: Corneal Edema
MeSH_CUI: M0024096
MeSH_DUI: D015715
MeSH_Definition: An excessive amount of fluid in the cornea due to damage of the epithelium or endothelium causing decreased visual acuity.
MeSH_Name: Corneal Edema
NUI: N0000003307
RxNorm_CUI: 1024597
SNOMED_CID: 193812004
SNOMED_CID: 27194006
UMLS_CUI: C0010037
code: C6792
imported from: NDF-RT.owl

Lentivirus Infections [Disease/Finding]
type: Class
subclass of: Retroviridae Infections [Disease/Finding]
Display_Name: Lentivirus Infections
MeSH_CUI: M0024697
MeSH_DUI: D016180
MeSH_Definition: Virus diseases caused by the Lentivirus genus. They are multi-organ diseases characterized by long incubation periods and persistent infection.
MeSH_Name: Lentivirus Infections
NUI: N0000003384
RxNorm_CUI: 1024090
SNOMED_CID: 24907000
Synonym: Infections, Lentivirus
UMLS_CUI: C0079680
code: C6946
imported from: NDF-RT.owl

AIDS-Related Opportunistic Infections [Disease/Finding]
type: Class
subclass of: Opportunistic Infections [Disease/Finding]
subclass of: HIV Infections [Disease/Finding]
Display_Name: AIDS-Related Opportunistic Infections
MeSH_CUI: M0025965
MeSH_DUI: D017088
MeSH_Definition: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.
MeSH_Name: AIDS-Related Opportunistic Infections
NUI: N0000003524
RxNorm_CUI: 1025910
Synonym: HIV-Related Opportunistic Infections
Synonym: Opportunistic Infections, AIDS-Related
Synonym: Opportunistic Infections, HIV-Related
UMLS_CUI: C0162526
code: C7226
imported from: NDF-RT.owl

Kidney Failure [Disease/Finding]
type: Class
subclass of: Renal Insufficiency [Disease/Finding]
Display_Name: Kidney Failure
MeSH_CUI: M0025974
MeSH_DUI: D051437
MeSH_Definition: A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism.
MeSH_Name: Kidney Failure
NUI: N0000003529
RxNorm_CUI: 1022860
SNOMED_CID: 266553002
SNOMED_CID: 42399005
Synonym: Renal Failure
UMLS_CUI: C0035078
code: C7236
imported from: NDF-RT.owl

Skin Diseases, Viral [Disease/Finding]
type: Class
subclass of: Skin Diseases, Infectious [Disease/Finding]
subclass of: Virus Diseases [Disease/Finding]
Display_Name: Skin Diseases, Viral
MeSH_CUI: M0026098
MeSH_DUI: D017193
MeSH_Definition: Skin diseases caused by viruses.
MeSH_Name: Skin Diseases, Viral
NUI: N0000003547
RxNorm_CUI: 1029386
SNOMED_CID: 128937004
Synonym: Viral Skin Diseases
UMLS_CUI: C0162628
code: C7272
imported from: NDF-RT.owl

Skin and Connective Tissue Diseases [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Skin and Connective Tissue Diseases
MeSH_CUI: M0026454
MeSH_DUI: D017437
MeSH_Definition: A collective term for diseases of the skin and its appendages and of connective tissue.
MeSH_Name: Skin and Connective Tissue Diseases
NUI: N0000003573
RxNorm_CUI: 1027511
UMLS_CUI: C0175166
code: C7324
imported from: NDF-RT.owl

Skin Diseases, Eczematous [Disease/Finding]
type: Class
subclass of: Skin Diseases [Disease/Finding]
Display_Name: Skin Diseases, Eczematous
MeSH_CUI: M0026466
MeSH_DUI: D017443
MeSH_Definition: Any of a variety of eruptive skin disorders characterized by erythema, oozing, vesiculation, and scaling. Etiology is varied.
MeSH_Name: Skin Diseases, Eczematous
NUI: N0000003576
RxNorm_CUI: 1022475
Synonym: Eczematous Disorders
Synonym: Eczematous Skin Diseases
UMLS_CUI: C0162817
code: C7330
imported from: NDF-RT.owl

Skin Diseases, Papulosquamous [Disease/Finding]
type: Class
subclass of: Skin Diseases [Disease/Finding]
Display_Name: Skin Diseases, Papulosquamous
MeSH_CUI: M0026467
MeSH_DUI: D017444
MeSH_Definition: A group of dermatoses with distinct morphologic features. The primary lesion is most commonly a papule, usually erythematous, with a variable degree of scaling on the surface. Plaques form through the coalescing of primary lesions.
MeSH_Name: Skin Diseases, Papulosquamous
NUI: N0000003577
RxNorm_CUI: 1024350
SNOMED_CID: 22585003
Synonym: Papulosquamous Disorders
Synonym: Papulosquamous Skin Diseases
UMLS_CUI: C0162818
code: C7332
imported from: NDF-RT.owl

Neuroectodermal Tumors [Disease/Finding]
type: Class
subclass of: Neoplasms, Germ Cell and Embryonal [Disease/Finding]
subclass of: Neoplasms, Nerve Tissue [Disease/Finding]
Display_Name: Neuroectodermal Tumors
MeSH_CUI: M0026668
MeSH_DUI: D017599
MeSH_Definition: Malignant neoplasms arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.
MeSH_Name: Neuroectodermal Tumors
NUI: N0000003613
RxNorm_CUI: 1022212
SNOMED_CID: 253096008
SNOMED_CID: 73676002
UMLS_CUI: C0206093
code: C7404
imported from: NDF-RT.owl

Neuroendocrine Tumors [Disease/Finding]
type: Class
subclass of: Neuroectodermal Tumors [Disease/Finding]
Display_Name: Neuroendocrine Tumors
MeSH_CUI: M0027590
MeSH_DUI: D018358
MeSH_Definition: Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
MeSH_Name: Neuroendocrine Tumors
NUI: N0000003804
RxNorm_CUI: 1024535
SNOMED_CID: 255046005
UMLS_CUI: C0206754
code: C7786
imported from: NDF-RT.owl

Neurobehavioral Manifestations [Disease/Finding]
type: Class
subclass of: Mental Disorders and Manifestations [Disease/Finding]
subclass of: Neurologic Manifestations [Disease/Finding]
Display_Name: Neurobehavioral Manifestations
MeSH_CUI: M0333801
MeSH_DUI: D019954
MeSH_Definition: Signs and symptoms of higher cortical dysfunction caused by organic conditions. These include certain behavioral alterations and impairments of skills involved in the acquisition, processing, and utilization of knowledge or information.
MeSH_Name: Neurobehavioral Manifestations
NUI: N0000003967
RxNorm_CUI: 1025867
Synonym: Cognitive Manifestations
Synonym: Cognitive Symptoms
Synonym: Neurobehavioral Signs and Symptoms
Synonym: Signs and Symptoms, Neurobehavioral
UMLS_CUI: C0525041
code: C8112
imported from: NDF-RT.owl

Delirium, Dementia, Amnestic, Cognitive Disorders [Disease/Finding]
type: Class
subclass of: Mental Disorders [Disease/Finding]
Display_Name: Delirium, Dementia, Amnestic, Cognitive Disorders
MeSH_CUI: M0029645
MeSH_DUI: D019965
MeSH_Definition: Cognitive disorders including delirium, dementia, and other cognitive disorders. These may be the result of substance use, trauma, or other causes.
MeSH_Name: Delirium, Dementia, Amnestic, Cognitive Disorders
NUI: N0000003976
RxNorm_CUI: 1022574
SNOMED_CID: 106014008
SNOMED_CID: 111479008
Synonym: Mental Disorders, Organic
Synonym: Organic Mental Disorders
UMLS_CUI: C0029227
code: C8130
imported from: NDF-RT.owl

Substance-Related Disorders [Disease/Finding]
type: Class
subclass of: Mental Disorders [Disease/Finding]
Display_Name: Substance-Related Disorders
MeSH_CUI: M0029657
MeSH_DUI: D019966
MeSH_Definition: Disorders related to substance abuse, the side effects of a medication, or toxin exposure.
MeSH_Name: Substance-Related Disorders
NUI: N0000003977
RxNorm_CUI: 1027904
UMLS_CUI: C0236969
code: C8132
imported from: NDF-RT.owl

Alcohol-Related Disorders [Disease/Finding]
type: Class
subclass of: Substance-Related Disorders [Disease/Finding]
Display_Name: Alcohol-Related Disorders
MeSH_CUI: M0029672
MeSH_DUI: D019973
MeSH_Definition: Disorders related to or resulting from abuse or mis-use of alcohol.
MeSH_Name: Alcohol-Related Disorders
NUI: N0000003982
RxNorm_CUI: 1025655
SNOMED_CID: 29212009
UMLS_CUI: C0236664
code: C8142
imported from: NDF-RT.owl

Coagulation Protein Disorders [Disease/Finding]
type: Class
subclass of: Blood Coagulation Disorders [Disease/Finding]
Display_Name: Coagulation Protein Disorders
MeSH_CUI: M0029880
MeSH_DUI: D020147
MeSH_Definition: Hemorrhagic and thrombotic disorders resulting from abnormalities or deficiencies of coagulation proteins.
MeSH_Name: Coagulation Protein Disorders
NUI: N0000004004
RxNorm_CUI: 1024212
Synonym: Blood Coagulation Factor Deficiencies
Synonym: Coagulation Proteins Disorders
UMLS_CUI: C0600503
code: C8186
imported from: NDF-RT.owl

Neurotoxicity Syndromes [Disease/Finding]
type: Class
subclass of: Nervous System Diseases [Disease/Finding]
subclass of: Poisoning [Disease/Finding]
Display_Name: Neurotoxicity Syndromes
MeSH_CUI: M0328313
MeSH_DUI: D020258
MeSH_Definition: Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. This includes conditions caused by biologic, chemical, and pharmaceutical agents.
MeSH_Name: Neurotoxicity Syndromes
NUI: N0000004080
RxNorm_CUI: 985040
SNOMED_CID: 19466003
Synonym: Nervous System Poisoning
Synonym: Neurotoxic Disorders
Synonym: Neurotoxin Diseases
Synonym: Neurotoxin Disorders
Synonym: Poisoning, Nervous System
UMLS_CUI: C0235032
code: C8338
imported from: NDF-RT.owl

Alcohol-Induced Disorders, Nervous System [Disease/Finding]
type: Class
subclass of: Neurotoxicity Syndromes [Disease/Finding]
subclass of: Alcohol-Induced Disorders [Disease/Finding]
Display_Name: Alcohol-Induced Disorders, Nervous System
MeSH_CUI: M0328091
MeSH_DUI: D020268
MeSH_Definition: Acute and chronic neurologic disorders associated with the various neurologic effects of ETHANOL. Primary sites of injury include the brain and peripheral nerves.
MeSH_Name: Alcohol-Induced Disorders, Nervous System
NUI: N0000004088
RxNorm_CUI: 1023561
Synonym: Alcohol Abuse, Nervous System
Synonym: Ethanol Induced Nervous System Disorders
Synonym: Ethanol-Induced Disorders, Nervous System
Synonym: Ethanol-Induced Nervous System Disorders
Synonym: Ethyl Alcohol Abuse Neurologic Syndromes
Synonym: Nervous System Disorders, Ethanol-Induced
UMLS_CUI: C0751865
code: C8354
imported from: NDF-RT.owl

Intracranial Hemorrhages [Disease/Finding]
type: Class
subclass of: Cerebrovascular Disorders [Disease/Finding]
subclass of: Hemorrhage [Disease/Finding]
Display_Name: Intracranial Hemorrhages
MeSH_CUI: M0328611
MeSH_DUI: D020300
MeSH_Definition: Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
MeSH_Name: Intracranial Hemorrhages
NUI: N0000004102
RxNorm_CUI: 1026294
SNOMED_CID: 1386000
Synonym: Hemorrhage, Intracranial
UMLS_CUI: C0151699
code: C8382
imported from: NDF-RT.owl

Alcohol-Induced Disorders [Disease/Finding]
type: Class
subclass of: Alcohol-Related Disorders [Disease/Finding]
Display_Name: Alcohol-Induced Disorders
MeSH_CUI: M0328025
MeSH_DUI: D020751
MeSH_Definition: Disorders stemming from the misuse and abuse of alcohol.
MeSH_Name: Alcohol-Induced Disorders
NUI: N0000004170
RxNorm_CUI: 1025678
UMLS_CUI: C0236970
code: C8518
imported from: NDF-RT.owl

Pathological Conditions, Anatomical [Disease/Finding]
type: Class
subclass of: Pathological Conditions, Signs and Symptoms [Disease/Finding]
Display_Name: Pathological Conditions, Anatomical
MeSH_CUI: M0328642
MeSH_DUI: D020763
MeSH_Definition: An abnormal structural condition of the human body, usually macroscopic, that is common to a variety of different diseases.
MeSH_Name: Pathological Conditions, Anatomical
NUI: N0000004178
RxNorm_CUI: 1026773
UMLS_CUI: C0752135
code: C8534
imported from: NDF-RT.owl

Neuromuscular Manifestations [Disease/Finding]
type: Class
subclass of: Neurologic Manifestations [Disease/Finding]
Display_Name: Neuromuscular Manifestations
MeSH_CUI: M0328296
MeSH_DUI: D020879
MeSH_Definition: Signs and symptoms associated with diseases of the muscle, neuromuscular junction, or peripheral nerves.
MeSH_Name: Neuromuscular Manifestations
NUI: N0000004213
RxNorm_CUI: 1027972
Synonym: Neuromuscular Signs and Symptoms
Synonym: Signs and Symptoms, Neuromuscular
UMLS_CUI: C0752252
code: C8604
imported from: NDF-RT.owl

Discrete Subaortic Stenosis [Disease/Finding]
type: Class
subclass of: Aortic Stenosis, Subvalvular [Disease/Finding]
Display_Name: Discrete Subaortic Stenosis
MeSH_CUI: M0001558
MeSH_DUI: D021922
MeSH_Definition: A type of constriction that is caused by the presence of a fibrous ring (discrete type) below the AORTIC VALVE, anywhere between the aortic valve and the MITRAL VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
MeSH_Name: Discrete Subaortic Stenosis
NUI: N0000004248
RxNorm_CUI: 1031927
Synonym: Subaortic Stenosis, Discrete
UMLS_CUI: C0012628
code: C8674
imported from: NDF-RT.owl

basiliximab [Chemical/Ingredient]
type: Class
subclass of: Antibodies, Monoclonal [Chemical/Ingredient]
subclass of: Recombinant Fusion Proteins [Chemical/Ingredient]
Display_Name: basiliximab
MeSH_CUI: M0292349
MeSH_DUI: C113157
MeSH_Name: basiliximab
NUI: N0000004374
RxNorm_CUI: 196102
RxNorm_Name: basiliximab
UMLS_CUI: C0676831
code: C11518
imported from: NDF-RT.owl

Carbohydrates [Chemical/Ingredient]
type: Class
subclass of: Chemical Ingredients [Chemical/Ingredient]
Display_Name: Carbohydrates
MeSH_CUI: M0003360
MeSH_DUI: D002241
MeSH_Definition: The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
MeSH_Name: Carbohydrates
NUI: N0000005723
RxNorm_CUI: 2028
UMLS_CUI: C0007004
code: C21790
imported from: NDF-RT.owl

Metolazone [Chemical/Ingredient]
type: Class
subclass of: Sulfonamides [Chemical/Ingredient]
subclass of: Quinazolinones [Chemical/Ingredient]
Display_Name: Metolazone
MeSH_CUI: M0013684
MeSH_DUI: D008788
MeSH_Definition: A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic RENAL FAILURE. It also tends to lower BLOOD PRESSURE and increase POTASSIUM loss.
MeSH_Name: Metolazone
NUI: N0000005746
RxNorm_CUI: 6916
RxNorm_Name: Metolazone
Synonym: 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-
UMLS_CUI: C0025854
code: C21836
imported from: NDF-RT.owl

Proteins [Chemical/Ingredient]
type: Class
subclass of: Amino Acids, Peptides, and Proteins [Chemical/Ingredient]
Display_Name: Proteins
MeSH_CUI: M0017890
MeSH_DUI: D011506
MeSH_Definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
MeSH_Name: Proteins
NUI: N0000005817
RxNorm_CUI: 8859
RxNorm_Name: Proteins
UMLS_CUI: C0033684
code: C21978
imported from: NDF-RT.owl

torsemide [Chemical/Ingredient]
type: Class
subclass of: Sulfonamides [Chemical/Ingredient]
Display_Name: torsemide
MeSH_CUI: M0086132
MeSH_DUI: C026116
MeSH_Name: torsemide
NUI: N0000006018
RxNorm_CUI: 38413
RxNorm_Name: torsemide
Synonym: 1-isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea
Synonym: 1-isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea
Synonym: torasemide
UMLS_CUI: C0076840
code: C22380
imported from: NDF-RT.owl

Dobutamine [Chemical/Ingredient]
type: Class
subclass of: Phenethylamines [Chemical/Ingredient]
subclass of: Catecholamines [Chemical/Ingredient]
Display_Name: Dobutamine
MeSH_CUI: M0006696
MeSH_DUI: D004280
MeSH_Definition: A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
MeSH_Name: Dobutamine
NUI: N0000006055
RxNorm_CUI: 3616
RxNorm_Name: Dobutamine
Synonym: 1,2-Benzenediol, 4-(2-((3-(4-hydroxyphenyl)-1-methylpropyl)amino)ethyl)-, (+-)-
UMLS_CUI: C0012963
code: C22454
imported from: NDF-RT.owl

Dopamine [Chemical/Ingredient]
type: Class
subclass of: Catecholamines [Chemical/Ingredient]
Display_Name: Dopamine
MeSH_CUI: M0006756
MeSH_DUI: D004298
MeSH_Definition: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
MeSH_Name: Dopamine
NUI: N0000006091
RxNorm_CUI: 3628
RxNorm_Name: Dopamine
Synonym: 1,2-Benzenediol, 4-(2-aminoethyl)-
Synonym: 3,4-Dihydroxyphenethylamine
Synonym: 4-(2-Aminoethyl)-1,2-benzenediol
Synonym: Hydroxytyramine
UMLS_CUI: C0013030
code: C22526
imported from: NDF-RT.owl

Lipids [Chemical/Ingredient]
type: Class
subclass of: Chemical Ingredients [Chemical/Ingredient]
Display_Name: Lipids
MeSH_CUI: M0012553
MeSH_DUI: D008055
MeSH_Definition: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
MeSH_Name: Lipids
NUI: N0000006185
RxNorm_CUI: 6411
UMLS_CUI: C0023779
code: C22714
imported from: NDF-RT.owl

Vitamin D [Chemical/Ingredient]
type: Class
subclass of: Secosteroids [Chemical/Ingredient]
Display_Name: Vitamin D
MeSH_CUI: M0022797
MeSH_DUI: D014807
MeSH_Definition: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
MeSH_Name: Vitamin D
NUI: N0000006277
RxNorm_CUI: 11253
RxNorm_Name: Vitamin D
UMLS_CUI: C0042866
code: C22900
imported from: NDF-RT.owl

Vitamin K [Chemical/Ingredient]
type: Class
subclass of: Naphthoquinones [Chemical/Ingredient]
subclass of: Phytol [Chemical/Ingredient]
Display_Name: Vitamin K
MeSH_CUI: M0022806
MeSH_DUI: D014812
MeSH_Definition: A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.
MeSH_Name: Vitamin K
NUI: N0000006290
RxNorm_CUI: 11258
RxNorm_Name: Vitamin K
UMLS_CUI: C0042878
code: C22926
imported from: NDF-RT.owl

Magnesium [Chemical/Ingredient]
type: Class
subclass of: Metals, Alkaline Earth [Chemical/Ingredient]
subclass of: Metals, Light [Chemical/Ingredient]
Display_Name: Magnesium
MeSH_CUI: M0012884
MeSH_DUI: D008274
MeSH_Definition: A metallic element that has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. It is important for the activity of many enzymes, especially those involved in OXIDATIVE PHOSPHORYLATION.
MeSH_Name: Magnesium
NUI: N0000006335
RxNorm_CUI: 6574
RxNorm_Name: Magnesium
UMLS_CUI: C0024467
code: C23018
imported from: NDF-RT.owl

Glucose [Chemical/Ingredient]
type: Class
subclass of: Hexoses [Chemical/Ingredient]
Display_Name: Glucose
MeSH_CUI: M0009339
MeSH_DUI: D005947
MeSH_Definition: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
MeSH_Name: Glucose
NUI: N0000006402
RxNorm_CUI: 4850
RxNorm_Name: Glucose
Synonym: D-Glucose
Synonym: Dextrose
UMLS_CUI: C0017725
code: C23152
imported from: NDF-RT.owl

Hydrochloric Acid [Chemical/Ingredient]
type: Class
subclass of: Acids, Noncarboxylic [Chemical/Ingredient]
subclass of: Chlorine Compounds [Chemical/Ingredient]
Display_Name: Hydrochloric Acid
MeSH_CUI: M0010701
MeSH_DUI: D006851
MeSH_Definition: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.
MeSH_Name: Hydrochloric Acid
NUI: N0000006448
RxNorm_CUI: 5486
RxNorm_Name: Hydrochloric Acid
Synonym: Hydrochloric acid
Synonym: Muriatic Acid
UMLS_CUI: C0020259
code: C23244
imported from: NDF-RT.owl

Calcifediol [Chemical/Ingredient]
type: Class
subclass of: Hydroxycholecalciferols [Chemical/Ingredient]
Display_Name: Calcifediol
MeSH_CUI: M0003141
MeSH_DUI: D002112
MeSH_Definition: The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
MeSH_Name: Calcifediol
NUI: N0000006507
RxNorm_CUI: 1889
RxNorm_Name: Calcifediol
Synonym: 25-Hydroxycholecalciferol
Synonym: 25-Hydroxyvitamin D 3
Synonym: 25-Hydroxyvitamin D3
Synonym: 9,10-Secocholesta-5,7,10(19)-triene-3,25-diol, (3beta,5Z,7E)-
Synonym: Calcidiol
UMLS_CUI: C0006657
code: C23362
imported from: NDF-RT.owl

Calcium [Chemical/Ingredient]
type: Class
subclass of: Blood Coagulation Factors [Chemical/Ingredient]
subclass of: Metals, Alkaline Earth [Chemical/Ingredient]
Display_Name: Calcium
MeSH_CUI: M0003153
MeSH_DUI: D002118
MeSH_Definition: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
MeSH_Name: Calcium
NUI: N0000006512
RxNorm_CUI: 1895
RxNorm_Name: Calcium
Synonym: Blood Coagulation Factor IV
Synonym: Coagulation Factor IV
Synonym: Factor IV
UMLS_CUI: C0006675
code: C23372
imported from: NDF-RT.owl

Calcium Chloride [Chemical/Ingredient]
type: Class
subclass of: Chlorides [Chemical/Ingredient]
subclass of: Calcium Compounds [Chemical/Ingredient]
Display_Name: Calcium Chloride
MeSH_CUI: M0003166
MeSH_DUI: D002122
MeSH_Definition: A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.
MeSH_Name: Calcium Chloride
NUI: N0000006545
RxNorm_CUI: 1901
RxNorm_Name: Calcium Chloride
Synonym: Calcium Chloride, Anhydrous
Synonym: Calcium chloride
UMLS_CUI: C0006686
code: C23438
imported from: NDF-RT.owl

Sodium Lactate [Chemical/Ingredient]
type: Class
subclass of: Lactates [Chemical/Ingredient]
Display_Name: Sodium Lactate
MeSH_CUI: M0028809
MeSH_DUI: D019354
MeSH_Definition: The sodium salt of racemic or inactive lactic acid. It is a hygroscopic agent used intravenously as a systemic and urinary alkalizer.
MeSH_Name: Sodium Lactate
NUI: N0000006559
RxNorm_CUI: 56489
RxNorm_Name: Sodium Lactate
UMLS_CUI: C0142874
code: C23466
imported from: NDF-RT.owl

Lactates [Chemical/Ingredient]
type: Class
subclass of: Hydroxy Acids [Chemical/Ingredient]
Display_Name: Lactates
MeSH_CUI: M0012155
MeSH_DUI: D007773
MeSH_Definition: Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
MeSH_Name: Lactates
NUI: N0000006568
RxNorm_CUI: 6201
UMLS_CUI: C0022924
code: C23484
imported from: NDF-RT.owl

Atracurium [Chemical/Ingredient]
type: Class
subclass of: Benzylisoquinolines [Chemical/Ingredient]
Display_Name: Atracurium
MeSH_CUI: M0001922
MeSH_DUI: D001279
MeSH_Definition: A non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate non-depolarizing neuromuscular blocking agents.
MeSH_Name: Atracurium
NUI: N0000006674
RxNorm_CUI: 1218
RxNorm_Name: Atracurium
Synonym: Isoquinolinium, 2,2'-(1,5-pentanediylbis(oxy(3-oxo-3,1-propanediyl)))bis(1-((3,4-dimethoxyphenyl)methyl))-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-
UMLS_CUI: C0004234
code: C23696
imported from: NDF-RT.owl

Nystatin [Chemical/Ingredient]
type: Class
subclass of: Macrolides [Chemical/Ingredient]
Display_Name: Nystatin
MeSH_CUI: M0015146
MeSH_DUI: D009761
MeSH_Definition: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.
MeSH_Name: Nystatin
NUI: N0000006699
RxNorm_CUI: 7597
RxNorm_Name: Nystatin
UMLS_CUI: C0028741
code: C23746
imported from: NDF-RT.owl

Sulbactam [Chemical/Ingredient]
type: Class
subclass of: Penicillins [Chemical/Ingredient]
Display_Name: Sulbactam
MeSH_CUI: M0020733
MeSH_DUI: D013407
MeSH_Definition: A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.
MeSH_Name: Sulbactam
NUI: N0000006841
RxNorm_CUI: 10167
RxNorm_Name: Sulbactam
Synonym: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, (2S-cis)-
Synonym: Penicillanic Acid Sulfone
UMLS_CUI: C0038665
code: C24032
imported from: NDF-RT.owl

Fatty Acids [Chemical/Ingredient]
type: Class
subclass of: Lipids [Chemical/Ingredient]
Display_Name: Fatty Acids
MeSH_CUI: M0008265
MeSH_DUI: D005227
MeSH_Definition: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
MeSH_Name: Fatty Acids
NUI: N0000006847
RxNorm_CUI: 4297
UMLS_CUI: C0015684
code: C24044
imported from: NDF-RT.owl

Chlorothiazide [Chemical/Ingredient]
type: Class
subclass of: Benzothiadiazines [Chemical/Ingredient]
Display_Name: Chlorothiazide
MeSH_CUI: M0004186
MeSH_DUI: D002740
MeSH_Definition: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)
MeSH_Name: Chlorothiazide
NUI: N0000006932
RxNorm_CUI: 2396
RxNorm_Name: Chlorothiazide
Synonym: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
UMLS_CUI: C0008273
code: C24214
imported from: NDF-RT.owl

Cholecalciferol [Chemical/Ingredient]
type: Class
subclass of: Vitamin D [Chemical/Ingredient]
subclass of: Sterols [Chemical/Ingredient]
subclass of: Cholestenes [Chemical/Ingredient]
Display_Name: Cholecalciferol
MeSH_CUI: M0004229
MeSH_DUI: D002762
MeSH_Definition: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
MeSH_Name: Cholecalciferol
NUI: N0000006996
RxNorm_CUI: 2418
RxNorm_Name: Cholecalciferol
Synonym: (3 beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
Synonym: 9,10-Secocholesta-5,7,10(19)-trien-3-ol, (3beta,5Z,7E)-
Synonym: Calciol
Synonym: Vitamin D 3
Synonym: Vitamin D3
UMLS_CUI: C0008318
code: C24342
imported from: NDF-RT.owl

Foscarnet [Chemical/Ingredient]
type: Class
subclass of: Phosphonoacetic Acid [Chemical/Ingredient]
Display_Name: Foscarnet
MeSH_CUI: M0026166
MeSH_DUI: D017245
MeSH_Definition: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
MeSH_Name: Foscarnet
NUI: N0000007166
RxNorm_CUI: 33562
RxNorm_Name: Foscarnet
Synonym: Phosphinecarboxylic acid, dihydroxy-, oxide
Synonym: Phosphonoformic Acid
UMLS_CUI: C0070895
code: C24684
imported from: NDF-RT.owl

Magnesium Chloride [Chemical/Ingredient]
type: Class
subclass of: Chlorides [Chemical/Ingredient]
subclass of: Magnesium Compounds [Chemical/Ingredient]
Display_Name: Magnesium Chloride
MeSH_CUI: M0023974
MeSH_DUI: D015636
MeSH_Definition: Magnesium chloride. An inorganic compound consisting of one magnesium and two chloride ions. The compound is used in medicine as a source of magnesium ions, which are essential for many cellular activities. It has also been used as a cathartic and in alloys.
MeSH_Name: Magnesium Chloride
NUI: N0000007198
RxNorm_CUI: 6579
RxNorm_Name: Magnesium Chloride
Synonym: Magnesium chloride (MgCl2)
Synonym: MgCl2
UMLS_CUI: C0024472
code: C24748
imported from: NDF-RT.owl

Sodium Chloride [Chemical/Ingredient]
type: Class
subclass of: Chlorides [Chemical/Ingredient]
subclass of: Sodium Compounds [Chemical/Ingredient]
Display_Name: Sodium Chloride
MeSH_CUI: M0020094
MeSH_DUI: D012965
MeSH_Definition: A ubiquitous sodium salt that is commonly used to season food. It plays an important biological role in maintaining the osmotic tension of blood and tissues. The OSMOLAR CONCENTRATION this and other SALTS accounts for SALINITY which influences the types of organisms that live in an ENVIRONMENT.
MeSH_Name: Sodium Chloride
NUI: N0000007207
RxNorm_CUI: 9863
RxNorm_Name: Sodium Chloride
Synonym: Sodium chloride (NaCl)
UMLS_CUI: C0037494
code: C24766
imported from: NDF-RT.owl

Tacrolimus [Chemical/Ingredient]
type: Class
subclass of: Macrolides [Chemical/Ingredient]
Display_Name: Tacrolimus
MeSH_CUI: M0025261
MeSH_DUI: D016559
MeSH_Definition: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
MeSH_Name: Tacrolimus
NUI: N0000007302
RxNorm_CUI: 42316
RxNorm_Name: Tacrolimus
Synonym: 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-p
UMLS_CUI: C0085149
code: C24956
imported from: NDF-RT.owl

Alkaloids [Chemical/Ingredient]
type: Class
subclass of: Heterocyclic Compounds [Chemical/Ingredient]
Display_Name: Alkaloids
MeSH_CUI: M0000713
MeSH_DUI: D000470
MeSH_Definition: Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
MeSH_Name: Alkaloids
NUI: N0000007503
RxNorm_CUI: 496
UMLS_CUI: C0002062
code: C25362
imported from: NDF-RT.owl

Phenethylamines [Chemical/Ingredient]
type: Class
subclass of: Ethylamines [Chemical/Ingredient]
Display_Name: Phenethylamines
MeSH_CUI: M0016506
MeSH_DUI: D010627
MeSH_Definition: A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)
MeSH_Name: Phenethylamines
NUI: N0000007526
RxNorm_CUI: 8127
Synonym: Phenylethylamines
UMLS_CUI: C0031399
code: C25408
imported from: NDF-RT.owl

Macrolides [Chemical/Ingredient]
type: Class
subclass of: Lactones [Chemical/Ingredient]
subclass of: Glycosides [Chemical/Ingredient]
subclass of: Macrocyclic Compounds [Chemical/Ingredient]
Display_Name: Macrolides
MeSH_CUI: M0028311
MeSH_DUI: D018942
MeSH_Definition: A group of macrocyclic compounds formed by chain extension of multiple PROPIONATES and cyclized into a large (typically 12, 14, 16) membered lactone. They are often glycosylated. Many of them are ANTIBIOTICS.
MeSH_Name: Macrolides
NUI: N0000007529
RxNorm_CUI: 586370
UMLS_CUI: C0282563
code: C25414
imported from: NDF-RT.owl

Anions [Chemical/Ingredient]
type: Class
subclass of: Ions [Chemical/Ingredient]
Display_Name: Anions
MeSH_CUI: M0001248
MeSH_DUI: D000838
MeSH_Definition: Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.
MeSH_Name: Anions
NUI: N0000007541
RxNorm_CUI: 853
UMLS_CUI: C0003075
code: C25438
imported from: NDF-RT.owl

Benzothiadiazines [Chemical/Ingredient]
type: Class
subclass of: Sulfonamides [Chemical/Ingredient]
subclass of: Heterocyclic Compounds, 2-Ring [Chemical/Ingredient]
subclass of: Thiazides [Chemical/Ingredient]
Display_Name: Benzothiadiazines
MeSH_CUI: M0002371
MeSH_DUI: D001581
MeSH_Definition: Heterocyclic compounds of a ring with SULFUR and two NITROGEN atoms fused to a BENZENE ring. Members inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.
MeSH_Name: Benzothiadiazines
NUI: N0000007554
RxNorm_CUI: 1414
UMLS_CUI: C0005084
code: C25464
imported from: NDF-RT.owl

Biogenic Monoamines [Chemical/Ingredient]
type: Class
subclass of: Biogenic Amines [Chemical/Ingredient]
Display_Name: Biogenic Monoamines
MeSH_CUI: M0023566
MeSH_DUI: D015306
MeSH_Definition: Biogenic amines having only one amine moiety. Included in this group are all natural monoamines formed by the enzymatic decarboxylation of natural amino acids.
MeSH_Name: Biogenic Monoamines
NUI: N0000007586
RxNorm_CUI: 1565
Synonym: Monoamines, Biogenic
UMLS_CUI: C0005497
code: C25528
imported from: NDF-RT.owl

Hexoses [Chemical/Ingredient]
type: Class
subclass of: Monosaccharides [Chemical/Ingredient]
Display_Name: Hexoses
MeSH_CUI: M0010338
MeSH_DUI: D006601
MeSH_Name: Hexoses
NUI: N0000007604
RxNorm_CUI: 5318
UMLS_CUI: C0019494
code: C25568
imported from: NDF-RT.owl

Quinazolines [Chemical/Ingredient]
type: Class
subclass of: Heterocyclic Compounds, 2-Ring [Chemical/Ingredient]
Display_Name: Quinazolines
MeSH_CUI: M0018336
MeSH_DUI: D011799
MeSH_Name: Quinazolines
NUI: N0000007605
RxNorm_CUI: 9064
UMLS_CUI: C0034407
code: C25570
imported from: NDF-RT.owl

Globulins [Chemical/Ingredient]
type: Class
subclass of: Proteins [Chemical/Ingredient]
Display_Name: Globulins
MeSH_CUI: M0009293
MeSH_DUI: D005916
MeSH_Name: Globulins
NUI: N0000007615
RxNorm_CUI: 4825
UMLS_CUI: C0017649
code: C25590
imported from: NDF-RT.owl

Acids [Chemical/Ingredient]
type: Class
subclass of: Inorganic Chemicals [Chemical/Ingredient]
Display_Name: Acids
MeSH_CUI: M0000220
MeSH_DUI: D000143
MeSH_Definition: Chemical compounds which yield hydrogen ions or protons when dissolved in water, whose hydrogen can be replaced by metals or basic radicals, or which react with bases to form salts and water (neutralization). An extension of the term includes substances dissolved in media other than water. (Grant & Hackh's Chemical Dictionary, 5th ed)
MeSH_Name: Acids
NUI: N0000007626
RxNorm_CUI: 230
UMLS_CUI: C0001128
code: C25612
imported from: NDF-RT.owl

Acids, Acyclic [Chemical/Ingredient]
type: Class
subclass of: Carboxylic Acids [Chemical/Ingredient]
Display_Name: Acids, Acyclic
MeSH_CUI: M0000221
MeSH_DUI: D000144
MeSH_Definition: Carboxylic acids that have open-chain molecular structures as opposed to ring-shaped structures.
MeSH_Name: Acids, Acyclic
NUI: N0000007627
RxNorm_CUI: 231
Synonym: Acyclic Acids
UMLS_CUI: C0001129
code: C25614
imported from: NDF-RT.owl

Acids, Noncarboxylic [Chemical/Ingredient]
type: Class
subclass of: Acids [Chemical/Ingredient]
Display_Name: Acids, Noncarboxylic
MeSH_CUI: M0000225
MeSH_DUI: D000148
MeSH_Definition: Inorganic acids with a non metal, other than carbon, attached to hydrogen, or an acid radical containing no carbon.
MeSH_Name: Acids, Noncarboxylic
NUI: N0000007630
RxNorm_CUI: 235
Synonym: Noncarboxylic Acids
UMLS_CUI: C0001133
code: C25620
imported from: NDF-RT.owl

Lactams [Chemical/Ingredient]
type: Class
subclass of: Amides [Chemical/Ingredient]
subclass of: Heterocyclic Compounds, 1-Ring [Chemical/Ingredient]
Display_Name: Lactams
MeSH_CUI: M0012143
MeSH_DUI: D007769
MeSH_Definition: Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
MeSH_Name: Lactams
NUI: N0000007642
RxNorm_CUI: 6195
UMLS_CUI: C0022914
code: C25644
imported from: NDF-RT.owl

Lactones [Chemical/Ingredient]
type: Class
subclass of: Organic Chemicals [Chemical/Ingredient]
Display_Name: Lactones
MeSH_CUI: M0012175
MeSH_DUI: D007783
MeSH_Definition: Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.
MeSH_Name: Lactones
NUI: N0000007646
RxNorm_CUI: 6209
UMLS_CUI: C0022947
code: C25652
imported from: NDF-RT.owl

Organic Chemicals [Chemical/Ingredient]
type: Class
subclass of: Chemical Ingredients [Chemical/Ingredient]
Display_Name: Organic Chemicals
MeSH_CUI: M0015401
MeSH_DUI: D009930
MeSH_Definition: A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.
MeSH_Name: Organic Chemicals
NUI: N0000007676
RxNorm_CUI: 7692
UMLS_CUI: C0029224
code: C25712
imported from: NDF-RT.owl

Amides [Chemical/Ingredient]
type: Class
subclass of: Organic Chemicals [Chemical/Ingredient]
Display_Name: Amides
MeSH_CUI: M0000897
MeSH_DUI: D000577
MeSH_Definition: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)
MeSH_Name: Amides
NUI: N0000007681
RxNorm_CUI: 633
UMLS_CUI: C0002482
code: C25722
imported from: NDF-RT.owl

Organophosphorus Compounds [Chemical/Ingredient]
type: Class
subclass of: Organic Chemicals [Chemical/Ingredient]
Display_Name: Organophosphorus Compounds
MeSH_CUI: M0015421
MeSH_DUI: D009943
MeSH_Definition: Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.
MeSH_Name: Organophosphorus Compounds
NUI: N0000007684
RxNorm_CUI: 7696
UMLS_CUI: C0029254
code: C25728
imported from: NDF-RT.owl

Phosphorus Acids [Chemical/Ingredient]
type: Class
subclass of: Acids, Noncarboxylic [Chemical/Ingredient]
subclass of: Phosphorus Compounds [Chemical/Ingredient]
Display_Name: Phosphorus Acids
MeSH_CUI: M0027146
MeSH_DUI: D017976
MeSH_Definition: Inorganic acids that contain phosphorus as an integral part of the molecule.
MeSH_Name: Phosphorus Acids
NUI: N0000007696
RxNorm_CUI: 67101
UMLS_CUI: C0206451
code: C25752
imported from: NDF-RT.owl

Chlorides [Chemical/Ingredient]
type: Class
subclass of: Hydrochloric Acid [Chemical/Ingredient]
subclass of: Anions [Chemical/Ingredient]
Display_Name: Chlorides
MeSH_CUI: M0004143
MeSH_DUI: D002712
MeSH_Definition: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.
MeSH_Name: Chlorides
NUI: N0000007711
RxNorm_CUI: 2364
UMLS_CUI: C0008203
code: C25782
imported from: NDF-RT.owl

Catecholamines [Chemical/Ingredient]
type: Class
subclass of: Biogenic Monoamines [Chemical/Ingredient]
Display_Name: Catecholamines
MeSH_CUI: M0003647
MeSH_DUI: D002395
MeSH_Definition: A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
MeSH_Name: Catecholamines
NUI: N0000007715
RxNorm_CUI: 2146
Synonym: Sympathins
UMLS_CUI: C0007412
code: C25790
imported from: NDF-RT.owl

Steroids [Chemical/Ingredient]
type: Class
subclass of: Polycyclic Compounds [Chemical/Ingredient]
Display_Name: Steroids
MeSH_CUI: M0020527
MeSH_DUI: D013256
MeSH_Definition: A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
MeSH_Name: Steroids
NUI: N0000007720
RxNorm_CUI: 10072
UMLS_CUI: C0038317
code: C25800
imported from: NDF-RT.owl

Phosphonoacetic Acid [Chemical/Ingredient]
type: Class
subclass of: Acetic Acids [Chemical/Ingredient]
subclass of: Phosphonic Acids [Chemical/Ingredient]
Display_Name: Phosphonoacetic Acid
MeSH_CUI: M0016688
MeSH_DUI: D010746
MeSH_Definition: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
MeSH_Name: Phosphonoacetic Acid
NUI: N0000007721
RxNorm_CUI: 8250
Synonym: Acetic acid, phosphono-
Synonym: Phosphonacetic Acid
UMLS_CUI: C0031681
code: C25802
imported from: NDF-RT.owl

Biogenic Amines [Chemical/Ingredient]
type: Class
subclass of: Amines [Chemical/Ingredient]
Display_Name: Biogenic Amines
MeSH_CUI: M0002518
MeSH_DUI: D001679
MeSH_Definition: A group of naturally occurring amines derived by enzymatic decarboxylation of the natural amino acids. Many have powerful physiological effects (e.g., histamine, serotonin, epinephrine, tyramine). Those derived from aromatic amino acids, and also their synthetic analogs (e.g., amphetamine), are of use in pharmacology.
MeSH_Name: Biogenic Amines
NUI: N0000007726
RxNorm_CUI: 1564
Synonym: Amines, Biogenic
Synonym: Biogenic Amine
UMLS_CUI: C0005496
code: C25812
imported from: NDF-RT.owl

Sterols [Chemical/Ingredient]
type: Class
subclass of: Membrane Lipids [Chemical/Ingredient]
subclass of: Cholestanes [Chemical/Ingredient]
Display_Name: Sterols
MeSH_CUI: M0020532
MeSH_DUI: D013261
MeSH_Definition: Steroids with a hydroxyl group at C-3 and most of the skeleton of cholestane. Additional carbon atoms may be present in the side chain. (IUPAC Steroid Nomenclature, 1987)
MeSH_Name: Sterols
NUI: N0000007730
RxNorm_CUI: 10077
UMLS_CUI: C0038323
code: C25820
imported from: NDF-RT.owl

Cholestenes [Chemical/Ingredient]
type: Class
subclass of: Cholestanes [Chemical/Ingredient]
Display_Name: Cholestenes
MeSH_CUI: M0004266
MeSH_DUI: D002782
MeSH_Definition: Steroids with methyl groups at C-10 and C-13 and a branched 8-carbon chain at C-17. Members include compounds with any degree of unsaturation; however, CHOLESTADIENES is available for derivatives containing two double bonds.
MeSH_Name: Cholestenes
NUI: N0000007759
RxNorm_CUI: 2436
UMLS_CUI: C0008375
code: C25878
imported from: NDF-RT.owl

Chlorine Compounds [Chemical/Ingredient]
type: Class
subclass of: Inorganic Chemicals [Chemical/Ingredient]
Display_Name: Chlorine Compounds
MeSH_CUI: M0026679
MeSH_DUI: D017606
MeSH_Definition: Inorganic compounds that contain chlorine as an integral part of the molecule.
MeSH_Name: Chlorine Compounds
NUI: N0000007794
RxNorm_CUI: 67167
Synonym: Chlorine Compounds, Inorganic
UMLS_CUI: C0206759
code: C25948
imported from: NDF-RT.owl

Calcium Compounds [Chemical/Ingredient]
type: Class
subclass of: Inorganic Chemicals [Chemical/Ingredient]
Display_Name: Calcium Compounds
MeSH_CUI: M0026683
MeSH_DUI: D017610
MeSH_Definition: Inorganic compounds that contain calcium as an integral part of the molecule.
MeSH_Name: Calcium Compounds
NUI: N0000007800
RxNorm_CUI: 66999
UMLS_CUI: C0206106
code: C25960
imported from: NDF-RT.owl

Magnesium Compounds [Chemical/Ingredient]
type: Class
subclass of: Inorganic Chemicals [Chemical/Ingredient]
Display_Name: Magnesium Compounds
MeSH_CUI: M0026689
MeSH_DUI: D017616
MeSH_Definition: Inorganic compounds that contain magnesium as an integral part of the molecule.
MeSH_Name: Magnesium Compounds
NUI: N0000007803
RxNorm_CUI: 67004
UMLS_CUI: C0206112
code: C25966
imported from: NDF-RT.owl

Naphthalenes [Chemical/Ingredient]
type: Class
subclass of: Polycyclic Hydrocarbons, Aromatic [Chemical/Ingredient]
Display_Name: Naphthalenes
MeSH_CUI: M0014459
MeSH_DUI: D009281
MeSH_Definition: Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
MeSH_Name: Naphthalenes
NUI: N0000007809
RxNorm_CUI: 7251
UMLS_CUI: C0027378
code: C25978
imported from: NDF-RT.owl

Bicyclo Compounds, Heterocyclic [Chemical/Ingredient]
type: Class
subclass of: Bicyclo Compounds [Chemical/Ingredient]
subclass of: Heterocyclic Compounds, Bridged-Ring [Chemical/Ingredient]
subclass of: Heterocyclic Compounds, 2-Ring [Chemical/Ingredient]
Display_Name: Bicyclo Compounds, Heterocyclic
MeSH_CUI: M0028488
MeSH_DUI: D019086
MeSH_Definition: A class of saturated compounds consisting of two rings only, having two or more atoms in common, containing at least one hetero atom, and that take the name of an open chain hydrocarbon containing the same total number of atoms. (From Riguady et al., Nomenclature of Organic Chemistry, 1979, p31)
MeSH_Name: Bicyclo Compounds, Heterocyclic
NUI: N0000007813
RxNorm_CUI: 82186
Synonym: Bicyclic Heterocyclic Compounds
Synonym: Heterocyclic Bicyclo Compounds
Synonym: Heterocyclic Cpds, Bicyclic
UMLS_CUI: C0282650
code: C25986
imported from: NDF-RT.owl

Naphthoquinones [Chemical/Ingredient]
type: Class
subclass of: Naphthalenes [Chemical/Ingredient]
subclass of: Quinones [Chemical/Ingredient]
Display_Name: Naphthoquinones
MeSH_CUI: M0014463
MeSH_DUI: D009285
MeSH_Definition: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
MeSH_Name: Naphthoquinones
NUI: N0000007814
RxNorm_CUI: 7255
Synonym: Naphthalenediones
UMLS_CUI: C0027388
code: C25988
imported from: NDF-RT.owl

Membrane Lipids [Chemical/Ingredient]
type: Class
subclass of: Lipids [Chemical/Ingredient]
Display_Name: Membrane Lipids
MeSH_CUI: M0013338
MeSH_DUI: D008563
MeSH_Definition: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
MeSH_Name: Membrane Lipids
NUI: N0000007818
RxNorm_CUI: 6723
Synonym: Cell Membrane Lipids
UMLS_CUI: C0025249
code: C25996
imported from: NDF-RT.owl

Amino Acids, Peptides, and Proteins [Chemical/Ingredient]
type: Class
subclass of: Chemical Ingredients [Chemical/Ingredient]
Display_Name: Amino Acids, Peptides, and Proteins
MeSH_CUI: M0000928
MeSH_DUI: D000602
MeSH_Definition: Amino acids and chains of amino acids connected by peptide linkages.
MeSH_Name: Amino Acids, Peptides, and Proteins
NUI: N0000007833
RxNorm_CUI: 664
UMLS_CUI: C0002526
code: C26026
imported from: NDF-RT.owl

Sodium Compounds [Chemical/Ingredient]
type: Class
subclass of: Inorganic Chemicals [Chemical/Ingredient]
Display_Name: Sodium Compounds
MeSH_CUI: M0026726
MeSH_DUI: D017670
MeSH_Definition: Inorganic compounds that contain sodium as an integral part of the molecule.
MeSH_Name: Sodium Compounds
NUI: N0000007844
RxNorm_CUI: 67017
UMLS_CUI: C0206134
code: C26048
imported from: NDF-RT.owl

Peptides [Chemical/Ingredient]
type: Class
subclass of: Amino Acids, Peptides, and Proteins [Chemical/Ingredient]
Display_Name: Peptides
MeSH_CUI: M0016238
MeSH_DUI: D010455
MeSH_Definition: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
MeSH_Name: Peptides
NUI: N0000007874
RxNorm_CUI: 8036
UMLS_CUI: C0030956
code: C26108
imported from: NDF-RT.owl

Glycosides [Chemical/Ingredient]
type: Class
subclass of: Carbohydrates [Chemical/Ingredient]
Display_Name: Glycosides
MeSH_CUI: M0009500
MeSH_DUI: D006027
MeSH_Definition: Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
MeSH_Name: Glycosides
NUI: N0000007897
RxNorm_CUI: 4958
UMLS_CUI: C0017977
code: C26154
imported from: NDF-RT.owl

Elements [Chemical/Ingredient]
type: Class
subclass of: Inorganic Chemicals [Chemical/Ingredient]
Display_Name: Elements
MeSH_CUI: M0007227
MeSH_DUI: D004602
MeSH_Definition: Substances that comprise all matter. Each element is made up of atoms that are identical in number of electrons and protons and in nuclear charge, but may differ in mass or number of neutrons.
MeSH_Name: Elements
NUI: N0000007912
RxNorm_CUI: 3802
UMLS_CUI: C0013879
code: C26186
imported from: NDF-RT.owl

Blood Coagulation Factors [Chemical/Ingredient]
type: Class
subclass of: Blood Proteins [Chemical/Ingredient]
subclass of: Biological Factors [Chemical/Ingredient]
Display_Name: Blood Coagulation Factors
MeSH_CUI: M0002684
MeSH_DUI: D001779
MeSH_Definition: Endogenous substances, usually proteins, that are involved in the blood coagulation process.
MeSH_Name: Blood Coagulation Factors
NUI: N0000007914
RxNorm_CUI: 1637
Synonym: Blood Coagulation Factor
Synonym: Coagulation Factor
Synonym: Coagulation Factor, Blood
Synonym: Coagulation Factors
Synonym: Coagulation Factors, Blood
Synonym: Factor, Coagulation
Synonym: Factors, Coagulation
UMLS_CUI: C0005789
code: C26190
imported from: NDF-RT.owl

Secosteroids [Chemical/Ingredient]
type: Class
subclass of: Steroids [Chemical/Ingredient]
Display_Name: Secosteroids
MeSH_CUI: M0019588
MeSH_DUI: D012632
MeSH_Definition: Steroids in which fission of one or more ring structures and concomitant addition of a hydrogen atom at each terminal group has occurred.
MeSH_Name: Secosteroids
NUI: N0000007915
RxNorm_CUI: 9626
UMLS_CUI: C0036532
code: C26192
imported from: NDF-RT.owl

Immunoglobulins [Chemical/Ingredient]
type: Class
subclass of: Immunoproteins [Chemical/Ingredient]
subclass of: Serum Globulins [Chemical/Ingredient]
Display_Name: Immunoglobulins
MeSH_CUI: M0011122
MeSH_DUI: D007136
MeSH_Definition: Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
MeSH_Name: Immunoglobulins
NUI: N0000007920
RxNorm_CUI: 5720
RxNorm_Name: Immunoglobulins
Synonym: Globulins, Immune
Synonym: Immune Globulins
Synonym: Immunoglobulin
UMLS_CUI: C0021027
code: C26202
imported from: NDF-RT.owl

Blood Proteins [Chemical/Ingredient]
type: Class
subclass of: Proteins [Chemical/Ingredient]
Display_Name: Blood Proteins
MeSH_CUI: M0002710
MeSH_DUI: D001798
MeSH_Definition: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.
MeSH_Name: Blood Proteins
NUI: N0000007921
RxNorm_CUI: 1653
UMLS_CUI: C0005832
code: C26204
imported from: NDF-RT.owl

Terpenes [Chemical/Ingredient]
type: Class
subclass of: Hydrocarbons [Chemical/Ingredient]
Display_Name: Terpenes
MeSH_CUI: M0021183
MeSH_DUI: D013729
MeSH_Definition: A class of compounds composed of repeating 5-carbon units of HEMITERPENES.
MeSH_Name: Terpenes
NUI: N0000007940
RxNorm_CUI: 10372
Synonym: Terpenoids
UMLS_CUI: C0039561
code: C26242
imported from: NDF-RT.owl

Recombinant Proteins [Chemical/Ingredient]
type: Class
subclass of: Proteins [Chemical/Ingredient]
Display_Name: Recombinant Proteins
MeSH_CUI: M0018641
MeSH_DUI: D011994
MeSH_Definition: Proteins prepared by recombinant DNA technology.
MeSH_Name: Recombinant Proteins
NUI: N0000007956
RxNorm_CUI: 9218
Synonym: Biosynthetic Proteins
Synonym: Proteins, Biosynthetic
UMLS_CUI: C0034861
code: C26276
imported from: NDF-RT.owl

Isoquinolines [Chemical/Ingredient]
type: Class
subclass of: Heterocyclic Compounds, 2-Ring [Chemical/Ingredient]
Display_Name: Isoquinolines
MeSH_CUI: M0011785
MeSH_DUI: D007546
MeSH_Definition: A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
MeSH_Name: Isoquinolines
NUI: N0000007960
RxNorm_CUI: 6056
UMLS_CUI: C0022248
code: C26284
imported from: NDF-RT.owl

Hydrocarbons [Chemical/Ingredient]
type: Class
subclass of: Organic Chemicals [Chemical/Ingredient]
Display_Name: Hydrocarbons
MeSH_CUI: M0010687
MeSH_DUI: D006838
MeSH_Name: Hydrocarbons
NUI: N0000007973
RxNorm_CUI: 5476
UMLS_CUI: C0020242
code: C26310
imported from: NDF-RT.owl

Hydroxy Acids [Chemical/Ingredient]
type: Class
subclass of: Carboxylic Acids [Chemical/Ingredient]
Display_Name: Hydroxy Acids
MeSH_CUI: M0010745
MeSH_DUI: D006880
MeSH_Definition: Organic compounds containing both the hydroxyl and carboxyl radicals.
MeSH_Name: Hydroxy Acids
NUI: N0000007983
RxNorm_CUI: 5515
UMLS_CUI: C0020317
code: C26330
imported from: NDF-RT.owl

Hydroxycholecalciferols [Chemical/Ingredient]
type: Class
subclass of: Cholecalciferol [Chemical/Ingredient]
Display_Name: Hydroxycholecalciferols
MeSH_CUI: M0010754
MeSH_DUI: D006887
MeSH_Definition: Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.
MeSH_Name: Hydroxycholecalciferols
NUI: N0000007988
RxNorm_CUI: 5522
Synonym: Hydroxycholecalciferol
Synonym: Hydroxyvitamins D
UMLS_CUI: C0020337
code: C26340
imported from: NDF-RT.owl

Metals, Alkaline Earth [Chemical/Ingredient]
type: Class
subclass of: Elements [Chemical/Ingredient]
subclass of: Metals [Chemical/Ingredient]
Display_Name: Metals, Alkaline Earth
MeSH_CUI: M0013518
MeSH_DUI: D008673
MeSH_Definition: Metals that constitute the group 2 (formerly group IIa) of the periodic table.
MeSH_Name: Metals, Alkaline Earth
NUI: N0000007992
RxNorm_CUI: 6800
Synonym: Alkaline Earth Metals
Synonym: Group 2 Elements
UMLS_CUI: C0025555
code: C26348
imported from: NDF-RT.owl

Metals, Light [Chemical/Ingredient]
type: Class
subclass of: Elements [Chemical/Ingredient]
subclass of: Metals [Chemical/Ingredient]
Display_Name: Metals, Light
MeSH_CUI: M0029055
MeSH_DUI: D019565
MeSH_Definition: Metals with low specific gravity, typically smaller than 5, characterized by a single valence (1, 2, or 3), a simple spectrum, strong electromotive force (positive), and colorless compounds. (From Grant & Hackh's Chemical Dictionary, 5th ed)
MeSH_Name: Metals, Light
NUI: N0000008004
RxNorm_CUI: 114297
Synonym: Light Metals
UMLS_CUI: C0376709
code: C26372
imported from: NDF-RT.owl

Ethylamines [Chemical/Ingredient]
type: Class
subclass of: Amines [Chemical/Ingredient]
Display_Name: Ethylamines
MeSH_CUI: M0007897
MeSH_DUI: D005021
MeSH_Name: Ethylamines
NUI: N0000008011
RxNorm_CUI: 4146
UMLS_CUI: C0015069
code: C26386
imported from: NDF-RT.owl

Sulfites [Chemical/Ingredient]
type: Class
subclass of: Anions [Chemical/Ingredient]
subclass of: Sulfur Compounds [Chemical/Ingredient]
Display_Name: Sulfites
MeSH_CUI: M0020784
MeSH_DUI: D013447
MeSH_Definition: Inorganic salts of sulfurous acid.
MeSH_Name: Sulfites
NUI: N0000008046
RxNorm_CUI: 10211
Synonym: Inorganic Sulfites
Synonym: Sulfites, Inorganic
UMLS_CUI: C0038750
code: C26456
imported from: NDF-RT.owl

Sulfonamides [Chemical/Ingredient]
type: Class
subclass of: Amides [Chemical/Ingredient]
subclass of: Sulfones [Chemical/Ingredient]
Display_Name: Sulfonamides
MeSH_CUI: M0020790
MeSH_DUI: D013449
MeSH_Definition: A group of compounds that contain the structure SO2NH2. Members of this group, also known as sulfa drugs, are derivatives of sulfanilamide, which competitively inhibit folic acid synthesis in microorganisms, and are bacteriostatic. They have been largely supplanted by more effective and less toxic antibiotics. (From Dorland, 28th ed)
MeSH_Name: Sulfonamides
NUI: N0000008048
RxNorm_CUI: 10215
UMLS_CUI: C0038760
code: C26460
imported from: NDF-RT.owl

Sulfones [Chemical/Ingredient]
type: Class
subclass of: Sulfur Compounds [Chemical/Ingredient]
Display_Name: Sulfones
MeSH_CUI: M0020791
MeSH_DUI: D013450
MeSH_Name: Sulfones
NUI: N0000008053
RxNorm_CUI: 10216
UMLS_CUI: C0038761
code: C26470
imported from: NDF-RT.owl

Heterocyclic Compounds [Chemical/Ingredient]
type: Class
subclass of: Chemical Ingredients [Chemical/Ingredient]
Display_Name: Heterocyclic Compounds
MeSH_CUI: M0010290
MeSH_DUI: D006571
MeSH_Definition: Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
MeSH_Name: Heterocyclic Compounds
NUI: N0000008095
RxNorm_CUI: 5283
UMLS_CUI: C0019398
code: C26554
imported from: NDF-RT.owl

Acetic Acids [Chemical/Ingredient]
type: Class
subclass of: Acids, Acyclic [Chemical/Ingredient]
subclass of: Fatty Acids, Volatile [Chemical/Ingredient]
Display_Name: Acetic Acids
MeSH_CUI: M0000132
MeSH_DUI: D000088
MeSH_Definition: Acetic acid and its derivatives which may be formed by substitution reactions. Mono- and di-substituted, as well as halogenated compounds have been synthesized.
MeSH_Name: Acetic Acids
NUI: N0000008114
RxNorm_CUI: 169
UMLS_CUI: C0000985
code: C26592
imported from: NDF-RT.owl

Carboxylic Acids [Chemical/Ingredient]
type: Class
subclass of: Organic Chemicals [Chemical/Ingredient]
Display_Name: Carboxylic Acids
MeSH_CUI: M0003405
MeSH_DUI: D002264
MeSH_Definition: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.
MeSH_Name: Carboxylic Acids
NUI: N0000008137
RxNorm_CUI: 2060
UMLS_CUI: C0007066
code: C26638
imported from: NDF-RT.owl

Bridged Compounds [Chemical/Ingredient]
type: Class
subclass of: Hydrocarbons, Cyclic [Chemical/Ingredient]
subclass of: Polycyclic Compounds [Chemical/Ingredient]
Display_Name: Bridged Compounds
MeSH_CUI: M0002922
MeSH_DUI: D001952
MeSH_Definition: Cyclic hydrocarbons that contain multiple rings and share one or more atoms.
MeSH_Name: Bridged Compounds
NUI: N0000008149
RxNorm_CUI: 1740
UMLS_CUI: C0006174
code: C26662
imported from: NDF-RT.owl

Phosphorus Compounds [Chemical/Ingredient]
type: Class
subclass of: Inorganic Chemicals [Chemical/Ingredient]
Display_Name: Phosphorus Compounds
MeSH_CUI: M0026614
MeSH_DUI: D017553
MeSH_Definition: Inorganic compounds that contain phosphorus as an integral part of the molecule.
MeSH_Name: Phosphorus Compounds
NUI: N0000008156
RxNorm_CUI: 67164
UMLS_CUI: C0206756
code: C26676
imported from: NDF-RT.owl

Polycyclic Hydrocarbons, Aromatic [Chemical/Ingredient]
type: Class
subclass of: Hydrocarbons, Aromatic [Chemical/Ingredient]
subclass of: Polycyclic Compounds [Chemical/Ingredient]
Display_Name: Polycyclic Hydrocarbons, Aromatic
MeSH_CUI: M0017164
MeSH_DUI: D011084
MeSH_Definition: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
MeSH_Name: Polycyclic Hydrocarbons, Aromatic
NUI: N0000008164
RxNorm_CUI: 8504
Synonym: Polycyclic Aromatic Hydrocarbons
Synonym: Polynuclear Aromatic Hydrocarbons
UMLS_CUI: C0032458
code: C26692
imported from: NDF-RT.owl

Amines [Chemical/Ingredient]
type: Class
subclass of: Organic Chemicals [Chemical/Ingredient]
Display_Name: Amines
MeSH_CUI: M0000913
MeSH_DUI: D000588
MeSH_Definition: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
MeSH_Name: Amines
NUI: N0000008168
RxNorm_CUI: 823705
UMLS_CUI: C0002508
code: C26700
imported from: NDF-RT.owl

Bicyclo Compounds [Chemical/Ingredient]
type: Class
subclass of: Bridged Compounds [Chemical/Ingredient]
Display_Name: Bicyclo Compounds
MeSH_CUI: M0002469
MeSH_DUI: D001643
MeSH_Name: Bicyclo Compounds
NUI: N0000008171
RxNorm_CUI: 1530
UMLS_CUI: C0005378
code: C26706
imported from: NDF-RT.owl

Fatty Acids, Volatile [Chemical/Ingredient]
type: Class
subclass of: Fatty Acids [Chemical/Ingredient]
Display_Name: Fatty Acids, Volatile
MeSH_CUI: M0008273
MeSH_DUI: D005232
MeSH_Definition: Short-chain fatty acids of up to six carbon atoms in length. They are the major end products of microbial fermentation in the ruminant digestive tract and have also been implicated in the causation of neurological diseases in humans.
MeSH_Name: Fatty Acids, Volatile
NUI: N0000008176
RxNorm_CUI: 4303
Synonym: Fatty Acids, Short-Chain
UMLS_CUI: C0015691
code: C26716
imported from: NDF-RT.owl

Phosphonic Acids [Chemical/Ingredient]
type: Class
subclass of: Organophosphorus Compounds [Chemical/Ingredient]
subclass of: Phosphorus Acids [Chemical/Ingredient]
Display_Name: Phosphonic Acids
MeSH_CUI: M0016684
MeSH_DUI: D010745
MeSH_Definition: Inorganic or organic derivatives of phosphonic acid with the general formula ROP(OH)2 or RP(=O)(OH)2. The tautomeric form of this compound (P(OH)3) is PHOSPHOROUS ACIDS. Nucleoside phosphonates have a phosphate-carbon bond that is more resistant to enzymatic cleavage than the normal phosphate-oxygen bond.
MeSH_Name: Phosphonic Acids
NUI: N0000008178
RxNorm_CUI: 8248
UMLS_CUI: C0031679
code: C26720
imported from: NDF-RT.owl

Quinones [Chemical/Ingredient]
type: Class
subclass of: Organic Chemicals [Chemical/Ingredient]
Display_Name: Quinones
MeSH_CUI: M0018356
MeSH_DUI: D011809
MeSH_Definition: Hydrocarbon rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
MeSH_Name: Quinones
NUI: N0000008181
RxNorm_CUI: 9083
UMLS_CUI: C0034435
code: C26726
imported from: NDF-RT.owl

Cholestanes [Chemical/Ingredient]
type: Class
subclass of: Steroids [Chemical/Ingredient]
Display_Name: Cholestanes
MeSH_CUI: M0004254
MeSH_DUI: D002776
MeSH_Definition: Derivatives of the saturated steroid cholestane with methyl groups at C-18 and C-19 and an iso-octyl side chain at C-17.
MeSH_Name: Cholestanes
NUI: N0000008187
RxNorm_CUI: 2432
UMLS_CUI: C0008366
code: C26738
imported from: NDF-RT.owl

Ions [Chemical/Ingredient]
type: Class
subclass of: Electrolytes [Chemical/Ingredient]
Display_Name: Ions
MeSH_CUI: M0011678
MeSH_DUI: D007477
MeSH_Definition: An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.
MeSH_Name: Ions
NUI: N0000008197
RxNorm_CUI: 5964
UMLS_CUI: C0022023
code: C26758
imported from: NDF-RT.owl

Diterpenes [Chemical/Ingredient]
type: Class
subclass of: Terpenes [Chemical/Ingredient]
Display_Name: Diterpenes
MeSH_CUI: M0006609
MeSH_DUI: D004224
MeSH_Definition: Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.
MeSH_Name: Diterpenes
NUI: N0000008216
RxNorm_CUI: 3557
Synonym: Diterpenoids
UMLS_CUI: C0012780
code: C26796
imported from: NDF-RT.owl

Immunoglobulin Fragments [Chemical/Ingredient]
type: Class
subclass of: Immunoglobulins [Chemical/Ingredient]
subclass of: Peptide Fragments [Chemical/Ingredient]
Display_Name: Immunoglobulin Fragments
MeSH_CUI: M0011106
MeSH_DUI: D007128
MeSH_Definition: Partial immunoglobulin molecules resulting from selective cleavage by proteolytic enzymes or generated through PROTEIN ENGINEERING techniques.
MeSH_Name: Immunoglobulin Fragments
NUI: N0000008221
RxNorm_CUI: 5710
UMLS_CUI: C0021009
code: C26806
imported from: NDF-RT.owl

Immunoproteins [Chemical/Ingredient]
type: Class
subclass of: Blood Proteins [Chemical/Ingredient]
Display_Name: Immunoproteins
MeSH_CUI: M0011167
MeSH_DUI: D007162
MeSH_Definition: Blood proteins whose activities affect or play a role in the functioning of the immune system.
MeSH_Name: Immunoproteins
NUI: N0000008223
RxNorm_CUI: 5744
UMLS_CUI: C0021072
code: C26810
imported from: NDF-RT.owl

Hydrocarbons, Aromatic [Chemical/Ingredient]
type: Class
subclass of: Hydrocarbons, Cyclic [Chemical/Ingredient]
Display_Name: Hydrocarbons, Aromatic
MeSH_CUI: M0010690
MeSH_DUI: D006841
MeSH_Definition: Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.
MeSH_Name: Hydrocarbons, Aromatic
NUI: N0000008229
RxNorm_CUI: 5479
Synonym: Aromatic Hydrocarbons
UMLS_CUI: C0020245
code: C26822
imported from: NDF-RT.owl

Metals [Chemical/Ingredient]
type: Class
subclass of: Inorganic Chemicals [Chemical/Ingredient]
Display_Name: Metals
MeSH_CUI: M0013515
MeSH_DUI: D008670
MeSH_Definition: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)
MeSH_Name: Metals
NUI: N0000008237
RxNorm_CUI: 6797
UMLS_CUI: C0025552
code: C26838
imported from: NDF-RT.owl

Serum Globulins [Chemical/Ingredient]
type: Class
subclass of: Globulins [Chemical/Ingredient]
subclass of: Blood Proteins [Chemical/Ingredient]
Display_Name: Serum Globulins
MeSH_CUI: M0019698
MeSH_DUI: D012712
MeSH_Definition: All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)
MeSH_Name: Serum Globulins
NUI: N0000008244
RxNorm_CUI: 9701
UMLS_CUI: C0036800
code: C26852
imported from: NDF-RT.owl

Sulfur Compounds [Chemical/Ingredient]
type: Class
subclass of: Organic Chemicals [Chemical/Ingredient]
subclass of: Inorganic Chemicals [Chemical/Ingredient]
Display_Name: Sulfur Compounds
MeSH_CUI: M0020800
MeSH_DUI: D013457
MeSH_Definition: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.
MeSH_Name: Sulfur Compounds
NUI: N0000008249
RxNorm_CUI: 10225
UMLS_CUI: C0038776
code: C26862
imported from: NDF-RT.owl

Monosaccharides [Chemical/Ingredient]
type: Class
subclass of: Carbohydrates [Chemical/Ingredient]
Display_Name: Monosaccharides
MeSH_CUI: M0014043
MeSH_DUI: D009005
MeSH_Definition: Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)
MeSH_Name: Monosaccharides
NUI: N0000008250
RxNorm_CUI: 7044
UMLS_CUI: C0026492
code: C26864
imported from: NDF-RT.owl

Inorganic Chemicals [Chemical/Ingredient]
type: Class
subclass of: Chemical Ingredients [Chemical/Ingredient]
Display_Name: Inorganic Chemicals
MeSH_CUI: M0011365
MeSH_DUI: D007287
MeSH_Definition: A broad class of substances encompassing all those that do not include carbon and its derivatives as their principal elements. However, carbides, carbonates, cyanides, cyanates, and carbon disulfide are included in this class.
MeSH_Name: Inorganic Chemicals
NUI: N0000008257
RxNorm_CUI: 5824
UMLS_CUI: C0021521
code: C26878
imported from: NDF-RT.owl

Heterocyclic Compounds, Bridged-Ring [Chemical/Ingredient]
type: Class
subclass of: Heterocyclic Compounds [Chemical/Ingredient]
Display_Name: Heterocyclic Compounds, Bridged-Ring
MeSH_CUI: M0010291
MeSH_DUI: D006572
MeSH_Definition: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.
MeSH_Name: Heterocyclic Compounds, Bridged-Ring
NUI: N0000008258
RxNorm_CUI: 5288
Synonym: Bridged-Ring Heterocyclic Compounds
UMLS_CUI: C0019403
code: C26880
imported from: NDF-RT.owl

Heterocyclic Compounds, 1-Ring [Chemical/Ingredient]
type: Class
subclass of: Heterocyclic Compounds [Chemical/Ingredient]
Display_Name: Heterocyclic Compounds, 1-Ring
MeSH_CUI: M0010292
MeSH_DUI: D006573
MeSH_Definition: A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.
MeSH_Name: Heterocyclic Compounds, 1-Ring
NUI: N0000008259
RxNorm_CUI: 5284
Synonym: Heterocyclic Cpds, 1-Ring
UMLS_CUI: C0019399
code: C26882
imported from: NDF-RT.owl

Heterocyclic Compounds, 2-Ring [Chemical/Ingredient]
type: Class
subclass of: Heterocyclic Compounds [Chemical/Ingredient]
Display_Name: Heterocyclic Compounds, 2-Ring
MeSH_CUI: M0010293
MeSH_DUI: D006574
MeSH_Definition: A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.
MeSH_Name: Heterocyclic Compounds, 2-Ring
NUI: N0000008260
RxNorm_CUI: 5285
UMLS_CUI: C0019400
code: C26884
imported from: NDF-RT.owl

Electrolytes [Chemical/Ingredient]
type: Class
subclass of: Inorganic Chemicals [Chemical/Ingredient]
Display_Name: Electrolytes
MeSH_CUI: M0007189
MeSH_DUI: D004573
MeSH_Definition: Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)
MeSH_Name: Electrolytes
NUI: N0000008272
RxNorm_CUI: 3793
UMLS_CUI: C0013832
code: C26910
imported from: NDF-RT.owl

Hydrocarbons, Cyclic [Chemical/Ingredient]
type: Class
subclass of: Hydrocarbons [Chemical/Ingredient]
Display_Name: Hydrocarbons, Cyclic
MeSH_CUI: M0010694
MeSH_DUI: D006844
MeSH_Definition: Organic compounds composed exclusively of carbon and hydrogen forming a closed ring that may be either alicyclic or aromatic.
MeSH_Name: Hydrocarbons, Cyclic
NUI: N0000008280
RxNorm_CUI: 5482
Synonym: Cyclic Hydrocarbons
UMLS_CUI: C0020248
code: C26926
imported from: NDF-RT.owl

Alveolar Surface Tension Alteration [PE]
type: Class
subclass of: Respiratory/Pulmonary Activity Alteration [PE]
Display_Name: Alveolar Surface Tension Alteration
NUI: N0000008293
RxNorm_CUI: 989276
UMLS_CUI: C1371276
code: C26952
imported from: NDF-RT.owl

Alveolar Surface Tension Reduction [PE]
type: Class
subclass of: Alveolar Surface Tension Alteration [PE]
Display_Name: Alveolar Surface Tension Reduction
NUI: N0000008294
RxNorm_CUI: 988631
UMLS_CUI: C1371492
code: C26954
imported from: NDF-RT.owl

Arterial Vasoconstriction [PE]
type: Class
subclass of: Vasoconstriction [PE]
Display_Name: Arterial Vasoconstriction
NUI: N0000008298
RxNorm_CUI: 986283
UMLS_CUI: C1371490
code: C26962
imported from: NDF-RT.owl

Arterial Vasodilation [PE]
type: Class
subclass of: Vasodilation [PE]
Display_Name: Arterial Vasodilation
NUI: N0000008299
RxNorm_CUI: 984618
UMLS_CUI: C1371278
code: C26964
imported from: NDF-RT.owl

Blood & Lymphatic Fluid Function Alteration [PE]
type: Class
subclass of: Hematologic Activity Alteration [PE]
Display_Name: Blood & Lymphatic Fluid Function Alteration
NUI: N0000008307
RxNorm_CUI: 988284
UMLS_CUI: C1371289
code: C26980
imported from: NDF-RT.owl

Carbohydrate Metabolism Alteration [PE]
type: Class
subclass of: Metabolic Activity Alteration [PE]
Display_Name: Carbohydrate Metabolism Alteration
NUI: N0000008327
RxNorm_CUI: 1033881
UMLS_CUI: C1371294
code: C27020
imported from: NDF-RT.owl

Cardiac Contractility Alteration [PE]
type: Class
subclass of: Cardiovascular Activity Alteration [PE]
Display_Name: Cardiac Contractility Alteration
NUI: N0000008328
RxNorm_CUI: 986415
UMLS_CUI: C1371293
code: C27022
imported from: NDF-RT.owl

Cardiac Rate Alteration [PE]
type: Class
subclass of: Cardiovascular Activity Alteration [PE]
Display_Name: Cardiac Rate Alteration
NUI: N0000008329
RxNorm_CUI: 985479
UMLS_CUI: C2825066
code: C27024
imported from: NDF-RT.owl

Cardiovascular Activity Alteration [PE]
type: Class
subclass of: Organ System Specific Effects [PE]
Display_Name: Cardiovascular Activity Alteration
NUI: N0000008331
RxNorm_CUI: 988145
UMLS_CUI: C1371291
code: C27028
imported from: NDF-RT.owl

Cell Wall Alteration [PE]
type: Class
subclass of: Cellular Structure Alteration [PE]
Display_Name: Cell Wall Alteration
NUI: N0000008336
RxNorm_CUI: 989278
UMLS_CUI: C1371484
code: C27038
imported from: NDF-RT.owl

Cellular Activity Alteration [PE]
type: Class
subclass of: Generalized Systemic Effects [PE]
Display_Name: Cellular Activity Alteration
NUI: N0000008337
RxNorm_CUI: 985006
UMLS_CUI: C1371483
code: C27040
imported from: NDF-RT.owl

Cellular Cycle Alteration [PE]
type: Class
subclass of: Cellular Activity Alteration [PE]
Display_Name: Cellular Cycle Alteration
NUI: N0000008339
RxNorm_CUI: 990947
UMLS_CUI: C1371481
code: C27044
imported from: NDF-RT.owl

Cellular Growth Phase Alteration [PE]
type: Class
subclass of: Cellular Cycle Alteration [PE]
Display_Name: Cellular Growth Phase Alteration
NUI: N0000008343
RxNorm_CUI: 987428
UMLS_CUI: C1371477
code: C27052
imported from: NDF-RT.owl

Cellular Growth Phase Arrest [PE]
type: Class
subclass of: Cellular Growth Phase Reduction [PE]
Display_Name: Cellular Growth Phase Arrest
NUI: N0000008344
RxNorm_CUI: 986074
UMLS_CUI: C1371476
code: C27054
imported from: NDF-RT.owl

Cellular Structure Alteration [PE]
type: Class
subclass of: Cellular Activity Alteration [PE]
Display_Name: Cellular Structure Alteration
NUI: N0000008346
RxNorm_CUI: 990421
UMLS_CUI: C1371474
code: C27058
imported from: NDF-RT.owl

Cellular Synthetic Activity Alteration [PE]
type: Class
subclass of: Cellular Cycle Alteration [PE]
Display_Name: Cellular Synthetic Activity Alteration
NUI: N0000008347
RxNorm_CUI: 989470
UMLS_CUI: C1371473
code: C27060
imported from: NDF-RT.owl

Coagulation Factor Activity Alteration [PE]
type: Class
subclass of: Coagulation Factor Alteration [PE]
Display_Name: Coagulation Factor Activity Alteration
NUI: N0000008362
RxNorm_CUI: 985279
UMLS_CUI: C1371467
code: C27090
imported from: NDF-RT.owl

Coagulation Factor Alteration [PE]
type: Class
subclass of: Hemostasis Alteration [PE]
Display_Name: Coagulation Factor Alteration
NUI: N0000008363
RxNorm_CUI: 1027093
UMLS_CUI: C1371466
code: C27092
imported from: NDF-RT.owl

DNA Replication Alteration [PE]
type: Class
subclass of: Nucleic Acid Replication Alteration [PE]
Display_Name: DNA Replication Alteration
NUI: N0000008380
RxNorm_CUI: 985410
UMLS_CUI: C1371458
code: C27126
imported from: NDF-RT.owl

Decreased Cell Wall Integrity [PE]
type: Class
subclass of: Cell Wall Alteration [PE]
Display_Name: Decreased Cell Wall Integrity
NUI: N0000008478
RxNorm_CUI: 985663
UMLS_CUI: C1371351
code: C27322
imported from: NDF-RT.owl

Decreased Cytokine Activity [PE]
type: Class
subclass of: Decreased Immunologically Active Molecule Activity [PE]
Display_Name: Decreased Cytokine Activity
NUI: N0000008571
RxNorm_CUI: 989703
UMLS_CUI: C1371548
code: C27508
imported from: NDF-RT.owl

Decreased Cytokine Production [PE]
type: Class
subclass of: Decreased Immunologically Active Molecule Production [PE]
Display_Name: Decreased Cytokine Production
NUI: N0000008573
RxNorm_CUI: 984977
UMLS_CUI: C1371550
code: C27512
imported from: NDF-RT.owl

Decreased DNA Replication [PE]
type: Class
subclass of: DNA Replication Alteration [PE]
Display_Name: Decreased DNA Replication
NUI: N0000008577
RxNorm_CUI: 989476
UMLS_CUI: C1371554
code: C27520
imported from: NDF-RT.owl

Decreased Hematopoiesis [PE]
type: Class
subclass of: Hematopoiesis Alteration [PE]
Display_Name: Decreased Hematopoiesis
NUI: N0000008656
RxNorm_CUI: 989826
UMLS_CUI: C2825067
code: C27678
imported from: NDF-RT.owl

Decreased Immunologically Active Molecule Activity [PE]
type: Class
subclass of: Immunologically Active Molecule Activity Alteration [PE]
subclass of: Decreased Immunologic Activity [PE]
Display_Name: Decreased Immunologically Active Molecule Activity
NUI: N0000008663
RxNorm_CUI: 988758
UMLS_CUI: C1371672
code: C27692
imported from: NDF-RT.owl

Decreased Immunologically Active Molecule Production [PE]
type: Class
subclass of: Immunologically Active Molecule Production Alteration [PE]
subclass of: Decreased Immunologic Activity [PE]
Display_Name: Decreased Immunologically Active Molecule Production
NUI: N0000008665
RxNorm_CUI: 987036
UMLS_CUI: C1371674
code: C27696
imported from: NDF-RT.owl

Decreased Intravascular Volume [PE]
type: Class
subclass of: Intravascular Volume Alteration [PE]
Display_Name: Decreased Intravascular Volume
NUI: N0000008669
RxNorm_CUI: 988730
UMLS_CUI: C1371678
code: C27704
imported from: NDF-RT.owl

Decreased Lymphocyte Cell Production [PE]
type: Class
subclass of: Decreased Hematopoiesis [PE]
Display_Name: Decreased Lymphocyte Cell Production
NUI: N0000008699
RxNorm_CUI: 990429
UMLS_CUI: C1371707
code: C27764
imported from: NDF-RT.owl

Decreased Protein Synthesis [PE]
type: Class
subclass of: Striated Muscle Anabolism Alteration [PE]
subclass of: Translation Alteration [PE]
Display_Name: Decreased Protein Synthesis
NUI: N0000008841
RxNorm_CUI: 987293
UMLS_CUI: C1371848
code: C28048
imported from: NDF-RT.owl

Decreased Respiratory Secretion Viscosity [PE]
type: Class
subclass of: Respiratory Secretion Viscosity Alteration [PE]
Display_Name: Decreased Respiratory Secretion Viscosity
NUI: N0000008867
RxNorm_CUI: 990251
UMLS_CUI: C1371874
code: C28100
imported from: NDF-RT.owl

Decreased Striated Muscle Contraction [PE]
type: Class
subclass of: Striated Muscle Contraction Alteration [PE]
Display_Name: Decreased Striated Muscle Contraction
NUI: N0000008953
RxNorm_CUI: 987443
UMLS_CUI: C1371959
code: C28272
imported from: NDF-RT.owl

Decreased T Lymphocyte Production [PE]
type: Class
subclass of: Decreased Lymphocyte Cell Production [PE]
Display_Name: Decreased T Lymphocyte Production
NUI: N0000008998
RxNorm_CUI: 986572
UMLS_CUI: C1372004
code: C28362
imported from: NDF-RT.owl

Electrical Activity Alteration [PE]
type: Class
subclass of: Nervous System Activity Alteration [PE]
Display_Name: Electrical Activity Alteration
NUI: N0000009027
RxNorm_CUI: 985119
UMLS_CUI: C1372033
code: C28420
imported from: NDF-RT.owl

Generalized Systemic Effects [PE]
type: Class
subclass of: Physiological Effects [PE]
Display_Name: Generalized Systemic Effects
NUI: N0000009057
RxNorm_CUI: 990172
UMLS_CUI: C1372062
code: C28480
imported from: NDF-RT.owl

Glycogen Metabolism Alteration [PE]
type: Class
subclass of: Polysaccharide Metabolism Alteration [PE]
Display_Name: Glycogen Metabolism Alteration
NUI: N0000009064
RxNorm_CUI: 988106
UMLS_CUI: C1372068
code: C28494
imported from: NDF-RT.owl

Hematologic Activity Alteration [PE]
type: Class
subclass of: Hemic/Lymphatic Activity Alteration [PE]
Display_Name: Hematologic Activity Alteration
NUI: N0000009065
RxNorm_CUI: 986633
UMLS_CUI: C1372069
code: C28496
imported from: NDF-RT.owl

Hematological Cell Quantity Alteration [PE]
type: Class
subclass of: Hematologic Activity Alteration [PE]
Display_Name: Hematological Cell Quantity Alteration
NUI: N0000009067
RxNorm_CUI: 989409
UMLS_CUI: C1372071
code: C28500
imported from: NDF-RT.owl

Hematopoiesis Alteration [PE]
type: Class
subclass of: Hematological Cell Quantity Alteration [PE]
Display_Name: Hematopoiesis Alteration
NUI: N0000009068
RxNorm_CUI: 988943
UMLS_CUI: C1372072
code: C28502
imported from: NDF-RT.owl

Hemic/Lymphatic Activity Alteration [PE]
type: Class
subclass of: Organ System Specific Effects [PE]
Display_Name: Hemic/Lymphatic Activity Alteration
NUI: N0000009069
RxNorm_CUI: 990696
UMLS_CUI: C1372073
code: C28504
imported from: NDF-RT.owl

Hemostasis Alteration [PE]
type: Class
subclass of: Hematologic Activity Alteration [PE]
Display_Name: Hemostasis Alteration
NUI: N0000009070
RxNorm_CUI: 989781
UMLS_CUI: C1372074
code: C28506
imported from: NDF-RT.owl

Immunologic Activity Alteration [PE]
type: Class
subclass of: Generalized Systemic Effects [PE]
Display_Name: Immunologic Activity Alteration
NUI: N0000009073
RxNorm_CUI: 990814
UMLS_CUI: C1372077
code: C28512
imported from: NDF-RT.owl

Immunologically Active Molecule Activity Alteration [PE]
type: Class
subclass of: Immunologic Activity Alteration [PE]
Display_Name: Immunologically Active Molecule Activity Alteration
NUI: N0000009074
RxNorm_CUI: 985286
UMLS_CUI: C1372078
code: C28514
imported from: NDF-RT.owl

Immunologically Active Molecule Production Alteration [PE]
type: Class
subclass of: Immunologic Activity Alteration [PE]
Display_Name: Immunologically Active Molecule Production Alteration
NUI: N0000009076
RxNorm_CUI: 989133
UMLS_CUI: C1372080
code: C28518
imported from: NDF-RT.owl

Increased Cardiac Muscle Organized Electrical Activity [PE]
type: Class
subclass of: Increased Muscular System Organized Electrical Activity [PE]
Display_Name: Increased Cardiac Muscle Organized Electrical Activity
NUI: N0000009168
RxNorm_CUI: 985492
UMLS_CUI: C1372172
code: C28702
imported from: NDF-RT.owl

Increased Coagulation Factor Activity [PE]
type: Class
subclass of: Coagulation Factor Activity Alteration [PE]
subclass of: Increased Coagulation Activity [PE]
Display_Name: Increased Coagulation Factor Activity
NUI: N0000009252
RxNorm_CUI: 985543
UMLS_CUI: C1372256
code: C28870
imported from: NDF-RT.owl

Increased Distal Tubule H+ Excretion [PE]
type: Class
subclass of: Increased Renal H+ Excretion [PE]
Display_Name: Increased Distal Tubule H+ Excretion
NUI: N0000009275
RxNorm_CUI: 989312
UMLS_CUI: C1372279
code: C28916
imported from: NDF-RT.owl

Increased Distal Tubule K+ Excretion [PE]
type: Class
subclass of: Increased Renal K+ Excretion [PE]
Display_Name: Increased Distal Tubule K+ Excretion
NUI: N0000009277
RxNorm_CUI: 984847
UMLS_CUI: C1372281
code: C28920
imported from: NDF-RT.owl

Increased Distal Tubule Na+ Excretion [PE]
type: Class
subclass of: Increased Renal Na+ Excretion [PE]
Display_Name: Increased Distal Tubule Na+ Excretion
NUI: N0000009279
RxNorm_CUI: 987639
UMLS_CUI: C1372283
code: C28924
imported from: NDF-RT.owl

Increased Glycogenesis [PE]
type: Class
subclass of: Glycogen Metabolism Alteration [PE]
Display_Name: Increased Glycogenesis
NUI: N0000009344
RxNorm_CUI: 985903
UMLS_CUI: C1372346
code: C29054
imported from: NDF-RT.owl

Increased Intravascular Volume [PE]
type: Class
subclass of: Intravascular Volume Alteration [PE]
Display_Name: Increased Intravascular Volume
NUI: N0000009361
RxNorm_CUI: 990010
UMLS_CUI: C1372361
code: C29088
imported from: NDF-RT.owl

Increased Loop of Henle Ca++ Excretion [PE]
type: Class
subclass of: Increased Renal Ca++ Excretion [PE]
subclass of: Increased Diuresis at Loop of Henle [PE]
Display_Name: Increased Loop of Henle Ca++ Excretion
NUI: N0000009381
RxNorm_CUI: 987937
UMLS_CUI: C1372380
code: C29128
imported from: NDF-RT.owl

Increased Loop of Henle Cl- Excretion [PE]
type: Class
subclass of: Increased Renal Cl- Excretion [PE]
subclass of: Increased Diuresis at Loop of Henle [PE]
Display_Name: Increased Loop of Henle Cl- Excretion
NUI: N0000009382
RxNorm_CUI: 985500
UMLS_CUI: C1372381
code: C29130
imported from: NDF-RT.owl

Increased Loop of Henle K+ Excretion [PE]
type: Class
subclass of: Increased Renal K+ Excretion [PE]
subclass of: Increased Diuresis at Loop of Henle [PE]
Display_Name: Increased Loop of Henle K+ Excretion
NUI: N0000009385
RxNorm_CUI: 985338
UMLS_CUI: C1372384
code: C29136
imported from: NDF-RT.owl

Increased Loop of Henle Mg++ Excretion [PE]
type: Class
subclass of: Increased Renal Mg++ Excretion [PE]
subclass of: Increased Diuresis at Loop of Henle [PE]
Display_Name: Increased Loop of Henle Mg++ Excretion
NUI: N0000009386
RxNorm_CUI: 985552
UMLS_CUI: C1372385
code: C29138
imported from: NDF-RT.owl

Increased Loop of Henle Na+ Excretion [PE]
type: Class
subclass of: Increased Renal Na+ Excretion [PE]
subclass of: Increased Diuresis at Loop of Henle [PE]
Display_Name: Increased Loop of Henle Na+ Excretion
NUI: N0000009387
RxNorm_CUI: 984850
UMLS_CUI: C1372386
code: C29140
imported from: NDF-RT.owl

Increased Metabolic Rate [PE]
type: Class
subclass of: Metabolic Rate Alteration [PE]
Display_Name: Increased Metabolic Rate
NUI: N0000009399
RxNorm_CUI: 1031046
UMLS_CUI: C1372398
code: C29164
imported from: NDF-RT.owl

Increased Muscular System Organized Electrical Activity [PE]
type: Class
subclass of: Increased Organized Electrical Activity [PE]
Display_Name: Increased Muscular System Organized Electrical Activity
NUI: N0000009446
RxNorm_CUI: 989860
UMLS_CUI: C1372445
code: C29258
imported from: NDF-RT.owl

Increased Organized Electrical Activity [PE]
type: Class
subclass of: Organized Electrical Activity Alteration [PE]
Display_Name: Increased Organized Electrical Activity
NUI: N0000009460
RxNorm_CUI: 985295
UMLS_CUI: C1372459
code: C29286
imported from: NDF-RT.owl

Increased Renal Ca++ Excretion [PE]
type: Class
subclass of: Increased Renal Ion Excretion [PE]
Display_Name: Increased Renal Ca++ Excretion
NUI: N0000009546
RxNorm_CUI: 988359
UMLS_CUI: C1372544
code: C29458
imported from: NDF-RT.owl

Increased Renal Cl- Excretion [PE]
type: Class
subclass of: Increased Renal Ion Excretion [PE]
Display_Name: Increased Renal Cl- Excretion
NUI: N0000009547
RxNorm_CUI: 988578
UMLS_CUI: C1372545
code: C29460
imported from: NDF-RT.owl

Increased Renal H+ Excretion [PE]
type: Class
subclass of: Increased Renal Ion Excretion [PE]
Display_Name: Increased Renal H+ Excretion
NUI: N0000009548
RxNorm_CUI: 989634
UMLS_CUI: C1372546
code: C29462
imported from: NDF-RT.owl

Increased Renal HCO3- Excretion [PE]
type: Class
subclass of: Increased Renal Ion Excretion [PE]
Display_Name: Increased Renal HCO3- Excretion
NUI: N0000009549
RxNorm_CUI: 986592
UMLS_CUI: C1372547
code: C29464
imported from: NDF-RT.owl

Increased Renal Ion Excretion [PE]
type: Class
subclass of: Renal Ion Transport Alteration [PE]
Display_Name: Increased Renal Ion Excretion
NUI: N0000009550
RxNorm_CUI: 989861
UMLS_CUI: C1372548
code: C29466
imported from: NDF-RT.owl

Increased Renal K+ Excretion [PE]
type: Class
subclass of: Increased Renal Ion Excretion [PE]
Display_Name: Increased Renal K+ Excretion
NUI: N0000009551
RxNorm_CUI: 986593
UMLS_CUI: C1372549
code: C29468
imported from: NDF-RT.owl

Increased Renal Mg++ Excretion [PE]
type: Class
subclass of: Increased Renal Ion Excretion [PE]
Display_Name: Increased Renal Mg++ Excretion
NUI: N0000009552
RxNorm_CUI: 989592
UMLS_CUI: C1372550
code: C29470
imported from: NDF-RT.owl

Increased Renal Na+ Excretion [PE]
type: Class
subclass of: Increased Renal Ion Excretion [PE]
Display_Name: Increased Renal Na+ Excretion
NUI: N0000009553
RxNorm_CUI: 986790
UMLS_CUI: C1372551
code: C29472
imported from: NDF-RT.owl

Intravascular Volume Alteration [PE]
type: Class
subclass of: Blood & Lymphatic Fluid Function Alteration [PE]
Display_Name: Intravascular Volume Alteration
NUI: N0000009732
RxNorm_CUI: 987907
UMLS_CUI: C1372729
code: C29830
imported from: NDF-RT.owl

Metabolic Activity Alteration [PE]
type: Class
subclass of: Generalized Systemic Effects [PE]
Display_Name: Metabolic Activity Alteration
NUI: N0000009748
RxNorm_CUI: 990190
UMLS_CUI: C1372744
code: C29862
imported from: NDF-RT.owl

Metabolic Rate Alteration [PE]
type: Class
subclass of: Metabolic Activity Alteration [PE]
Display_Name: Metabolic Rate Alteration
NUI: N0000009749
RxNorm_CUI: 986653
UMLS_CUI: C1372745
code: C29864
imported from: NDF-RT.owl

Musculoskeletal Activity Alteration [PE]
type: Class
subclass of: Organ System Specific Effects [PE]
Display_Name: Musculoskeletal Activity Alteration
NUI: N0000009755
RxNorm_CUI: 985711
UMLS_CUI: C1372751
code: C29876
imported from: NDF-RT.owl

Nervous System Activity Alteration [PE]
type: Class
subclass of: Organ System Specific Effects [PE]
Display_Name: Nervous System Activity Alteration
NUI: N0000009759
RxNorm_CUI: 987311
UMLS_CUI: C2916815
code: C29884
imported from: NDF-RT.owl

Nucleic Acid Replication Alteration [PE]
type: Class
subclass of: Cellular Synthetic Activity Alteration [PE]
Display_Name: Nucleic Acid Replication Alteration
NUI: N0000009766
RxNorm_CUI: 989424
UMLS_CUI: C1372762
code: C29898
imported from: NDF-RT.owl

Organ System Specific Effects [PE]
type: Class
subclass of: Physiological Effects [PE]
Display_Name: Organ System Specific Effects
NUI: N0000009770
RxNorm_CUI: 985923
UMLS_CUI: C1372766
code: C29906
imported from: NDF-RT.owl

Organic Ion Metabolism Alteration [PE]
type: Class
subclass of: Metabolic Activity Alteration [PE]
Display_Name: Organic Ion Metabolism Alteration
NUI: N0000009772
RxNorm_CUI: 987655
UMLS_CUI: C1372768
code: C29910
imported from: NDF-RT.owl

Organic Ion Synthesis Alteration [PE]
type: Class
subclass of: Organic Ion Metabolism Alteration [PE]
Display_Name: Organic Ion Synthesis Alteration
NUI: N0000009773
RxNorm_CUI: 988791
UMLS_CUI: C1372769
code: C29912
imported from: NDF-RT.owl

Organized Electrical Activity Alteration [PE]
type: Class
subclass of: Electrical Activity Alteration [PE]
Display_Name: Organized Electrical Activity Alteration
NUI: N0000009774
RxNorm_CUI: 988792
UMLS_CUI: C1372770
code: C29914
imported from: NDF-RT.owl

Physiological Effects [PE]
type: Class
subclass of: process
Display_Name: Physiological Effects
NUI: N0000009802
RxNorm_CUI: 984490
UMLS_CUI: C1372798
code: C29970
imported from: NDF-RT.owl

Positive Chronotropy [PE]
type: Class
subclass of: Cardiac Rate Alteration [PE]
Display_Name: Positive Chronotropy
NUI: N0000009808
RxNorm_CUI: 987259
UMLS_CUI: C1372804
code: C29982
imported from: NDF-RT.owl

Positive Inotropy [PE]
type: Class
subclass of: Cardiac Contractility Alteration [PE]
Display_Name: Positive Inotropy
NUI: N0000009809
RxNorm_CUI: 989869
UMLS_CUI: C1372805
code: C29984
imported from: NDF-RT.owl

Renal Arterial Vasodilation [PE]
type: Class
subclass of: Arterial Vasodilation [PE]
Display_Name: Renal Arterial Vasodilation
NUI: N0000009826
RxNorm_CUI: 988963
UMLS_CUI: C1372857
code: C30018
imported from: NDF-RT.owl

Renal Ion Transport Alteration [PE]
type: Class
subclass of: Renal/Urological Activity Alteration [PE]
Display_Name: Renal Ion Transport Alteration
NUI: N0000009830
RxNorm_CUI: 984183
UMLS_CUI: C1372861
code: C30026
imported from: NDF-RT.owl

Renal/Urological Activity Alteration [PE]
type: Class
subclass of: Organ System Specific Effects [PE]
Display_Name: Renal/Urological Activity Alteration
NUI: N0000009832
RxNorm_CUI: 988191
UMLS_CUI: C1372863
code: C30030
imported from: NDF-RT.owl

Respiratory Secretion Alteration [PE]
type: Class
subclass of: Respiratory/Pulmonary Activity Alteration [PE]
Display_Name: Respiratory Secretion Alteration
NUI: N0000009836
RxNorm_CUI: 984707
UMLS_CUI: C1372867
code: C30038
imported from: NDF-RT.owl

Respiratory Secretion Viscosity Alteration [PE]
type: Class
subclass of: Respiratory Secretion Alteration [PE]
Display_Name: Respiratory Secretion Viscosity Alteration
NUI: N0000009837
RxNorm_CUI: 986604
UMLS_CUI: C1372868
code: C30040
imported from: NDF-RT.owl

Respiratory/Pulmonary Activity Alteration [PE]
type: Class
subclass of: Organ System Specific Effects [PE]
Display_Name: Respiratory/Pulmonary Activity Alteration
NUI: N0000009839
RxNorm_CUI: 987910
UMLS_CUI: C1372870
code: C30044
imported from: NDF-RT.owl

Striated Muscle Metabolic Alteration [PE]
type: Class
subclass of: Musculoskeletal Activity Alteration [PE]
Display_Name: Striated Muscle Metabolic Alteration
NUI: N0000009876
RxNorm_CUI: 984454
UMLS_CUI: C2916793
code: C30118
imported from: NDF-RT.owl

Striated Muscle Anabolism Alteration [PE]
type: Class
subclass of: Striated Muscle Metabolic Alteration [PE]
Display_Name: Striated Muscle Anabolism Alteration
NUI: N0000009877
RxNorm_CUI: 989427
UMLS_CUI: C1372908
code: C30120
imported from: NDF-RT.owl

Striated Muscle Contraction Alteration [PE]
type: Class
subclass of: Musculoskeletal Activity Alteration [PE]
Display_Name: Striated Muscle Contraction Alteration
NUI: N0000009879
RxNorm_CUI: 984654
UMLS_CUI: C1372910
code: C30124
imported from: NDF-RT.owl

Translation Alteration [PE]
type: Class
subclass of: Cellular Synthetic Activity Alteration [PE]
Display_Name: Translation Alteration
NUI: N0000009894
RxNorm_CUI: 984492
UMLS_CUI: C1372925
code: C30154
imported from: NDF-RT.owl

Vascular Tone Alteration [PE]
type: Class
subclass of: Vascular Alterations [PE]
Display_Name: Vascular Tone Alteration
NUI: N0000009906
RxNorm_CUI: 987659
UMLS_CUI: C1372937
code: C30178
imported from: NDF-RT.owl

Vasoconstriction [PE]
type: Class
subclass of: Vascular Tone Alteration [PE]
Display_Name: Vasoconstriction
NUI: N0000009908
RxNorm_CUI: 1022844
UMLS_CUI: C0042396
code: C30182
imported from: NDF-RT.owl

Vasodilation [PE]
type: Class
subclass of: Vascular Tone Alteration [PE]
Display_Name: Vasodilation
NUI: N0000009909
RxNorm_CUI: 1021984
UMLS_CUI: C0042401
code: C30184
imported from: NDF-RT.owl

Unknown Cellular or Molecular Interaction [MoA]
type: Class
subclass of: Cellular or Molecular Interactions [MoA]
Display_Name: Unknown Cellular or Molecular Interaction
NUI: N0000009915
RxNorm_CUI: 990716
UMLS_CUI: C1373108
code: C30196
imported from: NDF-RT.owl

Adrenergic beta1-Agonists [MoA]
type: Class
subclass of: Adrenergic beta-Agonists [MoA]
Display_Name: Adrenergic beta1-Agonists
NUI: N0000009921
RxNorm_CUI: 988194
UMLS_CUI: C1373135
code: C30208
imported from: NDF-RT.owl

Systemic Arterial Vasoconstriction [PE]
type: Class
subclass of: Arterial Vasoconstriction [PE]
Display_Name: Systemic Arterial Vasoconstriction
NUI: N0000009941
RxNorm_CUI: 988324
UMLS_CUI: C1372835
code: C30250
imported from: NDF-RT.owl

Sterol Synthesis Inhibitors [MoA]
type: Class
subclass of: Enzyme Inhibitors [MoA]
Display_Name: Sterol Synthesis Inhibitors
NUI: N0000009956
RxNorm_CUI: 988794
UMLS_CUI: C1373112
code: C30280
imported from: NDF-RT.owl

Ergosterol Synthesis Inhibitors [MoA]
type: Class
subclass of: Sterol Synthesis Inhibitors [MoA]
Display_Name: Ergosterol Synthesis Inhibitors
NUI: N0000009957
RxNorm_CUI: 989198
UMLS_CUI: C1373130
code: C30282
imported from: NDF-RT.owl

Dose Forms [Dose Form]
type: Class
subclass of: material entity
Display_Name: RxNorm Dose Forms
NUI: N0000010010
RxNorm_CUI: 987323
UMLS_CUI: C2267212
code: C30528
imported from: NDF-RT.owl

Pregnancy [Disease/Finding]
type: Class
subclass of: Physiologic States [Disease/Finding]
Display_Name: Pregnancy
NUI: N0000010195
RxNorm_CUI: 1022794
SNOMED_CID: 289908002
UMLS_CUI: C0032961
code: C31746
imported from: NDF-RT.owl

Physiologic States [Disease/Finding]
type: Class
subclass of: Diseases, Manifestations or Physiologic States [Disease/Finding]
Display_Name: Physiologic States
NUI: N0000010197
RxNorm_CUI: 989040
UMLS_CUI: C2916830
code: C31750
imported from: NDF-RT.owl

Antibody Interactions [MoA]
type: Class
subclass of: Immunologic Factors [MoA]
Display_Name: Antibody Interactions
NUI: N0000010226
RxNorm_CUI: 987958
UMLS_CUI: C2916825
code: C31810
imported from: NDF-RT.owl

Interleukin 2 Receptor Interactions [MoA]
type: Class
subclass of: Cytokine Receptor Superfamily Interactions [MoA]
Display_Name: Interleukin 2 Receptor Interactions
NUI: N0000010278
RxNorm_CUI: 984934
Synonym: IL2 Receptor Interactions
UMLS_CUI: C1373153
code: C31914
imported from: NDF-RT.owl

Interleukin 2 Receptor Antagonists [MoA]
type: Class
subclass of: Interleukin 2 Receptor Interactions [MoA]
Display_Name: Interleukin 2 Receptor Antagonists
NUI: N0000010279
RxNorm_CUI: 986467
Synonym: IL2 Receptor Antagonists
Synonym: IL2 Receptor Blockers
Synonym: IL2 Receptor Inhibitors
Synonym: Interleukin 2 Receptor Blockers
Synonym: Interleukin 2 Receptor Inhibitors
UMLS_CUI: C1373152
code: C31916
imported from: NDF-RT.owl

Drug Products by VA Class
type: Class
subclass of: OBI_0000047
Display_Name: Drug Products by VA Class
NUI: N0000010574
RxNorm_CUI: 985512
UMLS_CUI: C2267083
code: C281072
imported from: NDF-RT.owl

Drug Products by Generic Ingredient Combinations
type: Class
subclass of: OBI_0000047
Display_Name: Drug Products by Generic Ingredient Combinations
NUI: N0000010582
RxNorm_CUI: 987399
UMLS_CUI: C2267084
code: C288626
imported from: NDF-RT.owl

B [Preparations]
type: Class
subclass of: Drug Products by Generic Ingredient Combinations
Display_Name: B [Preparations]
NUI: N0000010584
RxNorm_CUI: 987472
UMLS_CUI: C2267086
code: C288628
imported from: NDF-RT.owl

C [Preparations]
type: Class
subclass of: Drug Products by Generic Ingredient Combinations
Display_Name: C [Preparations]
NUI: N0000010585
RxNorm_CUI: 987820
UMLS_CUI: C2267087
code: C288629
imported from: NDF-RT.owl

D [Preparations]
type: Class
subclass of: Drug Products by Generic Ingredient Combinations
Display_Name: D [Preparations]
NUI: N0000010586
RxNorm_CUI: 990856
UMLS_CUI: C2267088
code: C288630
imported from: NDF-RT.owl

E [Preparations]
type: Class
subclass of: Drug Products by Generic Ingredient Combinations
Display_Name: E [Preparations]
NUI: N0000010587
RxNorm_CUI: 984666
UMLS_CUI: C2267089
code: C288631
imported from: NDF-RT.owl

F [Preparations]
type: Class
subclass of: Drug Products by Generic Ingredient Combinations
Display_Name: F [Preparations]
NUI: N0000010588
RxNorm_CUI: 986610
UMLS_CUI: C2267090
code: C288632
imported from: NDF-RT.owl

G [Preparations]
type: Class
subclass of: Drug Products by Generic Ingredient Combinations
Display_Name: G [Preparations]
NUI: N0000010589
RxNorm_CUI: 986405
UMLS_CUI: C2267091
code: C288633
imported from: NDF-RT.owl

M [Preparations]
type: Class
subclass of: Drug Products by Generic Ingredient Combinations
Display_Name: M [Preparations]
NUI: N0000010595
RxNorm_CUI: 989499
UMLS_CUI: C2267095
code: C288639
imported from: NDF-RT.owl

N [Preparations]
type: Class
subclass of: Drug Products by Generic Ingredient Combinations
Display_Name: N [Preparations]
NUI: N0000010596
RxNorm_CUI: 984993
UMLS_CUI: C2267096
code: C288640
imported from: NDF-RT.owl

S [Preparations]
type: Class
subclass of: Drug Products by Generic Ingredient Combinations
Display_Name: S [Preparations]
NUI: N0000010601
RxNorm_CUI: 985848
UMLS_CUI: C2267101
code: C288645
imported from: NDF-RT.owl

T [Preparations]
type: Class
subclass of: Drug Products by Generic Ingredient Combinations
Display_Name: T [Preparations]
NUI: N0000010602
RxNorm_CUI: 989806
UMLS_CUI: C2267102
code: C288646
imported from: NDF-RT.owl

V [Preparations]
type: Class
subclass of: Drug Products by Generic Ingredient Combinations
Display_Name: V [Preparations]
NUI: N0000010604
RxNorm_CUI: 984196
UMLS_CUI: C2267104
code: C288648
imported from: NDF-RT.owl

Blood Coagulation Disorders, Inherited [Disease/Finding]
type: Class
subclass of: Blood Coagulation Disorders [Disease/Finding]
subclass of: Genetic Diseases, Inborn [Disease/Finding]
Display_Name: Blood Coagulation Disorders, Inherited
MeSH_CUI: M0376236
MeSH_DUI: D025861
MeSH_Definition: Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation.
MeSH_Name: Blood Coagulation Disorders, Inherited
NUI: N0000010965
RxNorm_CUI: 1028383
Synonym: Coagulation Disorders, Inherited
Synonym: Hereditary Blood Coagulation Disorders
Synonym: Hereditary Coagulation Disorders
Synonym: Inherited Blood Coagulation Disorders
Synonym: Inherited Coagulation Disorders
UMLS_CUI: C0852077
code: C291318
imported from: NDF-RT.owl

Malnutrition [Disease/Finding]
type: Class
subclass of: Nutrition Disorders [Disease/Finding]
Display_Name: Malnutrition
MeSH_CUI: M0015121
MeSH_DUI: D044342
MeSH_Definition: An imbalanced nutritional status resulted from insufficient intake of nutrients to meet normal physiological requirement.
MeSH_Name: Malnutrition
NUI: N0000011099
RxNorm_CUI: 1021991
SNOMED_CID: 65404009
SNOMED_CID: 70241007
Synonym: Nutritional Deficiency
Synonym: Undernutrition
UMLS_CUI: C0162429
code: C291452
imported from: NDF-RT.owl

Genetic Diseases, Inborn [Disease/Finding]
type: Class
subclass of: Congenital, Hereditary, and Neonatal Diseases and Abnormalities [Disease/Finding]
Display_Name: Genetic Diseases, Inborn
MeSH_CUI: M0385531
MeSH_DUI: D030342
MeSH_Definition: Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.
MeSH_Name: Genetic Diseases, Inborn
NUI: N0000011105
RxNorm_CUI: 1025368
Synonym: Inborn Genetic Diseases
UMLS_CUI: C0950123
code: C291458
imported from: NDF-RT.owl

Glucose Metabolism Disorders [Disease/Finding]
type: Class
subclass of: Metabolic Diseases [Disease/Finding]
Display_Name: Glucose Metabolism Disorders
MeSH_CUI: M0446458
MeSH_DUI: D044882
MeSH_Definition: Pathological conditions in which the BLOOD GLUCOSE cannot be maintained within the normal range, such as in HYPOGLYCEMIA and HYPERGLYCEMIA. Etiology of these disorders varies. Plasma glucose concentration is critical to survival for it is the predominant fuel for the CENTRAL NERVOUS SYSTEM.
MeSH_Name: Glucose Metabolism Disorders
NUI: N0000011123
RxNorm_CUI: 989730
SNOMED_CID: 126877002
Synonym: Glucose Metabolic Disorder
Synonym: Glucose Metabolic Disorders
Synonym: Glucose Metabolism Disorder
UMLS_CUI: C1257958
code: C291476
imported from: NDF-RT.owl

beta-Lactams [Chemical/Ingredient]
type: Class
subclass of: Lactams [Chemical/Ingredient]
subclass of: Sulfur Compounds [Chemical/Ingredient]
subclass of: Azabicyclo Compounds [Chemical/Ingredient]
Display_Name: beta-Lactams
MeSH_CUI: M0012144
MeSH_DUI: D047090
MeSH_Definition: Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
MeSH_Name: beta-Lactams
NUI: N0000011162
RxNorm_CUI: 82034
UMLS_CUI: C0282215
code: C291518
imported from: NDF-RT.owl

Antibodies, Monoclonal [Chemical/Ingredient]
type: Class
subclass of: Antibodies [Chemical/Ingredient]
Display_Name: Antibodies, Monoclonal
MeSH_CUI: M0001357
MeSH_DUI: D000911
MeSH_Definition: Antibodies produced by a single clone of cells.
MeSH_Name: Antibodies, Monoclonal
NUI: N0000011174
RxNorm_CUI: 911
Synonym: Monoclonal Antibodies
UMLS_CUI: C0003250
code: C291530
imported from: NDF-RT.owl

Antibodies [Chemical/Ingredient]
type: Class
subclass of: Immunoglobulins [Chemical/Ingredient]
Display_Name: Antibodies
MeSH_CUI: M0001352
MeSH_DUI: D000906
MeSH_Definition: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
MeSH_Name: Antibodies
NUI: N0000011175
RxNorm_CUI: 904
UMLS_CUI: C0003241
code: C291531
imported from: NDF-RT.owl

Recombinant Fusion Proteins [Chemical/Ingredient]
type: Class
subclass of: Recombinant Proteins [Chemical/Ingredient]
Display_Name: Recombinant Fusion Proteins
MeSH_CUI: M0018640
MeSH_DUI: D011993
MeSH_Definition: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
MeSH_Name: Recombinant Fusion Proteins
NUI: N0000011180
RxNorm_CUI: 9217
Synonym: Fusion Proteins, Recombinant
UMLS_CUI: C0034857
code: C291536
imported from: NDF-RT.owl

Penicillins [Chemical/Ingredient]
type: Class
subclass of: beta-Lactams [Chemical/Ingredient]
Display_Name: Penicillins
MeSH_CUI: M0016152
MeSH_DUI: D010406
MeSH_Definition: A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
MeSH_Name: Penicillins
NUI: N0000011281
RxNorm_CUI: 7986
Synonym: Antibiotics, Penicillin
UMLS_CUI: C0030842
code: C291637
imported from: NDF-RT.owl

Biological Factors [Chemical/Ingredient]
type: Class
subclass of: Chemical Ingredients [Chemical/Ingredient]
Display_Name: Biological Factors
MeSH_CUI: M0002530
MeSH_DUI: D001685
MeSH_Definition: Endogenously-synthesized compounds that may influence biological phenomena or represent quantifiable biomarkers. Biological factors are a variety of extracellular substances that are not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS
MeSH_Name: Biological Factors
NUI: N0000011290
RxNorm_CUI: 1570
Synonym: Biologic Factors
Synonym: Biological Factor
Synonym: Factor, Biologic
Synonym: Factor, Biological
Synonym: Factors, Biological
UMLS_CUI: C0005515
code: C291646
imported from: NDF-RT.owl

Aza Compounds [Chemical/Ingredient]
type: Class
subclass of: Organic Chemicals [Chemical/Ingredient]
Display_Name: Aza Compounds
MeSH_CUI: M0002056
MeSH_DUI: D001372
MeSH_Name: Aza Compounds
NUI: N0000011324
RxNorm_CUI: 1249
UMLS_CUI: C0004471
code: C291680
imported from: NDF-RT.owl

Phytol [Chemical/Ingredient]
type: Class
subclass of: Diterpenes [Chemical/Ingredient]
Display_Name: Phytol
MeSH_CUI: M0016825
MeSH_DUI: D010836
MeSH_Name: Phytol
NUI: N0000011327
RxNorm_CUI: 8306
Synonym: 2-Hexadecen-1-ol, 3,7,11,15-tetramethyl-, (R-(R*,R*-(E)))-
UMLS_CUI: C0031860
code: C291683
imported from: NDF-RT.owl

Macrocyclic Compounds [Chemical/Ingredient]
type: Class
subclass of: Polycyclic Compounds [Chemical/Ingredient]
Display_Name: Macrocyclic Compounds
MeSH_CUI: M0456185
MeSH_DUI: D047028
MeSH_Definition: Cyclic compounds with a ring size of approximately 1-4 dozen atoms.
MeSH_Name: Macrocyclic Compounds
NUI: N0000011330
RxNorm_CUI: 469970
Synonym: Macrocycle Compounds
UMLS_CUI: C1449665
code: C291686
imported from: NDF-RT.owl

Polycyclic Compounds [Chemical/Ingredient]
type: Class
subclass of: Chemical Ingredients [Chemical/Ingredient]
Display_Name: Polycyclic Compounds
MeSH_CUI: M0017162
MeSH_DUI: D011083
MeSH_Definition: Compounds consisting of two or more fused ring structures.
MeSH_Name: Polycyclic Compounds
NUI: N0000011331
RxNorm_CUI: 8502
UMLS_CUI: C0032456
code: C291687
imported from: NDF-RT.owl

Benzylisoquinolines [Chemical/Ingredient]
type: Class
subclass of: Alkaloids [Chemical/Ingredient]
subclass of: Isoquinolines [Chemical/Ingredient]
Display_Name: Benzylisoquinolines
MeSH_CUI: M0444533
MeSH_DUI: D044182
MeSH_Definition: ISOQUINOLINES with a benzyl substituent.
MeSH_Name: Benzylisoquinolines
NUI: N0000011356
RxNorm_CUI: 382269
Synonym: Benzyl-Isoquinolines
UMLS_CUI: C1257875
code: C291712
imported from: NDF-RT.owl

cisatracurium [Chemical/Ingredient]
type: Class
subclass of: Atracurium [Chemical/Ingredient]
Display_Name: cisatracurium
MeSH_CUI: M0415709
MeSH_DUI: C101584
MeSH_Name: cisatracurium
NUI: N0000011420
RxNorm_CUI: 319864
RxNorm_Name: Cisatracurium
UMLS_CUI: C1096766
code: C291777
imported from: NDF-RT.owl

Peptide Fragments [Chemical/Ingredient]
type: Class
subclass of: Peptides [Chemical/Ingredient]
Display_Name: Peptide Fragments
MeSH_CUI: M0016224
MeSH_DUI: D010446
MeSH_Definition: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
MeSH_Name: Peptide Fragments
NUI: N0000011457
RxNorm_CUI: 8027
UMLS_CUI: C0030935
code: C291814
imported from: NDF-RT.owl

Vascular Alterations [PE]
type: Class
subclass of: Cardiovascular Activity Alteration [PE]
Display_Name: Vascular Alterations
NUI: N0000020002
RxNorm_CUI: 984378
UMLS_CUI: C2267116
code: C300387
imported from: NDF-RT.owl

Cellular Growth Phase Reduction [PE]
type: Class
subclass of: Cellular Growth Phase Alteration [PE]
Display_Name: Cellular Growth Phase Reduction
NUI: N0000020013
RxNorm_CUI: 986120
UMLS_CUI: C2267126
code: C300398
imported from: NDF-RT.owl

Polysaccharide Metabolism Alteration [PE]
type: Class
subclass of: Carbohydrate Metabolism Alteration [PE]
Display_Name: Polysaccharide Metabolism Alteration
NUI: N0000020040
RxNorm_CUI: 986121
UMLS_CUI: C2267149
code: C300430
imported from: NDF-RT.owl

CALCIFEDIOL
type: Class
subclass of: C [Preparations]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Calcifediol [Chemical/Ingredient]
Display_Name: CALCIFEDIOL
Level: Ingredient
NUI: N0000020410
RxNorm_CUI: 1889
RxNorm_Name: Calcifediol
Status: Active
UMLS_CUI: C0006657
VANDF_Record: <VANDF_Record>50.6^831^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>831</VA_IEN>
VUID: 4022405
code: C288945
imported from: NDF-RT.owl

DEXTROSE/PERITONEAL DIALYSIS SOLUTION
type: Class
subclass of: D [Preparations]
Display_Name: DEXTROSE/PERITONEAL DIALYSIS SOLUTION
Level: Ingredient
NUI: N0000020502
RxNorm_CUI: 690658
Status: Active
UMLS_CUI: C1875006
VANDF_Record: <VANDF_Record>50.6^1029^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>1029</VA_IEN>
VUID: 4022497
code: C289035
imported from: NDF-RT.owl

DIGOXIN IMMUNE FAB
type: Class
subclass of: D [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_MoA
  some values from: Antibody Interactions [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Hematologic Activity Alteration [PE]
subclass of: Restriction
  on property: may_prevent
  some values from: Abnormalities, Drug-Induced [Disease/Finding]
subclass of: Restriction
  on property: may_prevent
  some values from: Drug Toxicity [Disease/Finding]
subclass of: Restriction
  on property: may_prevent
  some values from: Overdose [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Drug Toxicity [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Overdose [Disease/Finding]
Display_Name: DIGOXIN IMMUNE FAB
Level: Ingredient
NUI: N0000021229
RxNorm_CUI: 203223
RxNorm_Name: digoxin antibodies Fab fragments
Status: Active
UMLS_CUI: C0700607
VANDF_Record: <VANDF_Record>50.6^2146^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>2146</VA_IEN>
VUID: 4023224
code: C13774
imported from: NDF-RT.owl

CISATRACURIUM
type: Class
subclass of: C [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: cisatracurium [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Competitive Cholinergic Nicotinic Antagonists [MoA]
subclass of: Restriction
  on property: has_MoA
  some values from: Cholinergic Neuromuscular Nicotinic Antagonists [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Striated Muscle Contraction [PE]
subclass of: Restriction
  on property: induces
  some values from: Muscle Hypotonia [Disease/Finding]
subclass of: Restriction
  on property: induces
  some values from: Unconsciousness [Disease/Finding]
Display_Name: CISATRACURIUM
Level: Ingredient
NUI: N0000022024
RxNorm_CUI: 319864
RxNorm_Name: Cisatracurium
Status: Active
UMLS_CUI: C1096766
VANDF_Record: <VANDF_Record>50.6^3337^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>3337</VA_IEN>
VUID: 4024019
code: C12888
imported from: NDF-RT.owl

[AM000] ANTIMICROBIALS
type: Class
subclass of: Drug Products by VA Class
Class_Code: AM000
Class_Description: NOTE: Combination products containing two or more active ingredients from the same subclassification are classified in that subclassification (e.g.,triple sulfas in AM650). Products containing two or more active ingredients from different subclassifications are classified under "anti-infectives, other" (e.g., tetracycline and amphotericin B (AM900). Products containing probenecid or clavulanic acid are classified under the subclassification of the antimicrobial agent. Beta-lactam antibiotics not classified under penicillins or cephalosporins are classified (AM130). Excludes topical anti-infectives (DE100), topical anti- infective/anti-inflammatory combinations (DE250), ophthalmic anti-infectives (OP200), ophthalmic anti- infective/anti-inflammatory combinations (OP350), otic anti-infectives (OT100), otic anti-infective/anti- inflammatory combinations (OT250); vaginal anti- infectives (GU300).
Display_Name: ANTIMICROBIALS
Level: VA Class
NUI: N0000029074
RxNorm_CUI: 337867
Status: Active
UMLS_CUI: C1136254
VANDF_Record: <VANDF_Record>50.605^9^</VANDF_Record><VA_File>50.605</VA_File><VA_IEN>9</VA_IEN>
VUID: 4021521
code: C8716
imported from: NDF-RT.owl

[AM700] ANTIFUNGALS
type: Class
subclass of: [AM000] ANTIMICROBIALS
Class_Code: AM700
Display_Name: ANTIFUNGALS
Level: VA Class
NUI: N0000029088
RxNorm_CUI: 938
RxNorm_Name: Antifungal Agents
Status: Active
UMLS_CUI: C0003308
VANDF_Record: <VANDF_Record>50.605^24^</VANDF_Record><VA_File>50.605</VA_File><VA_IEN>24</VA_IEN>
VUID: 4021535
code: C8758
imported from: NDF-RT.owl

[IR000] IRRIGATION/DIALYSIS SOLUTIONS
type: Class
subclass of: Drug Products by VA Class
Class_Code: IR000
Class_Description: NOTE: Excludes 50% dimethyl sulfoxide (GU900).
Display_Name: IRRIGATION/DIALYSIS SOLUTIONS
Level: VA Class
NUI: N0000029202
RxNorm_CUI: 691815
Status: Active
UMLS_CUI: C1875396
VANDF_Record: <VANDF_Record>50.605^148^</VANDF_Record><VA_File>50.605</VA_File><VA_IEN>148</VA_IEN>
VUID: 4021649
code: C9166
imported from: NDF-RT.owl

[IR200] PERITONEAL DIALYSIS SOLUTIONS
type: Class
subclass of: [IR000] IRRIGATION/DIALYSIS SOLUTIONS
Class_Code: IR200
Display_Name: PERITONEAL DIALYSIS SOLUTIONS
Level: VA Class
NUI: N0000029204
RxNorm_CUI: 103997
Status: Active
UMLS_CUI: C0353714
VANDF_Record: <VANDF_Record>50.605^150^</VANDF_Record><VA_File>50.605</VA_File><VA_IEN>150</VA_IEN>
VUID: 4021651
code: C9170
imported from: NDF-RT.owl

Injectable Solution [Dose Form]
type: Class
subclass of: Solution [Dose Form]
Display_Name: Injectable Solution
NUI: N0000135717
RxNorm_CUI: 316949
RxNorm_Name: Injectable Solution
UMLS_CUI: C0991511
code: C30468
imported from: NDF-RT.owl

Intraperitoneal Solution [Dose Form]
type: Class
subclass of: Injectable Solution [Dose Form]
Display_Name: Intraperitoneal Solution
NUI: N0000135721
RxNorm_CUI: 316951
RxNorm_Name: Intraperitoneal Solution
UMLS_CUI: C0991513
code: C30472
imported from: NDF-RT.owl

Liquid [Dose Form]
type: Class
subclass of: Orderable Drug Form [Dose Form]
Display_Name: Liquid
NUI: N0000135726
RxNorm_CUI: 90230
RxNorm_Name: Liquid
UMLS_CUI: C1697794
code: C30406
imported from: NDF-RT.owl

Oral Suspension [Dose Form]
type: Class
subclass of: Suspension [Dose Form]
Display_Name: Oral Suspension
NUI: N0000135760
RxNorm_CUI: 316969
RxNorm_Name: Oral Suspension
UMLS_CUI: C0991537
code: C30516
imported from: NDF-RT.owl

Orderable Drug Form [Dose Form]
type: Class
subclass of: Dose Forms [Dose Form]
Display_Name: Orderable Drug Form
NUI: N0000135762
RxNorm_CUI: 316970
RxNorm_Name: Orderable Drug Form
UMLS_CUI: C0991538
code: C30518
imported from: NDF-RT.owl

Solution [Dose Form]
type: Class
subclass of: Liquid [Dose Form]
Display_Name: Solution
NUI: N0000135783
RxNorm_CUI: 450530
RxNorm_Name: Solution
UMLS_CUI: C1382100
code: C30372
imported from: NDF-RT.owl

Suspension [Dose Form]
type: Class
subclass of: Liquid [Dose Form]
Display_Name: Suspension
NUI: N0000135787
RxNorm_CUI: 10269
RxNorm_Name: Suspension
UMLS_CUI: C0038960
code: C30376
imported from: NDF-RT.owl

SODIUM CHLORIDE
type: Class
subclass of: S [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Alkalosis [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Edema [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Hypernatremia [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Pulmonary Edema [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Sodium Chloride [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Electrolyte Activity [MoA]
subclass of: Restriction
  on property: has_MoA
  some values from: Acid-Base Activity [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Alveolar Surface Tension Reduction [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Respiratory Secretion Viscosity [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Intravascular Volume [PE]
subclass of: Restriction
  on property: may_prevent
  some values from: Dehydration [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Dehydration [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Hyponatremia [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Shock, Hemorrhagic [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Wounds and Injuries [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Dry Eye Syndromes [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Corneal Edema [Disease/Finding]
Display_Name: SODIUM CHLORIDE
FDA_UNII: 451W47IQ8X
Level: Ingredient
NUI: N0000145832
RxNorm_CUI: 9863
RxNorm_Name: Sodium Chloride
Status: Active
UMLS_CUI: C0037494
VANDF_Record: <VANDF_Record>50.416^35^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>35</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^42^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>42</VA_IEN>
VUID: 4017444
code: C19958
imported from: NDF-RT.owl

NYSTATIN
type: Class
subclass of: N [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Nystatin [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Ergosterol Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Cell Wall Integrity [PE]
subclass of: Restriction
  on property: may_prevent
  some values from: Candidiasis, Cutaneous [Disease/Finding]
subclass of: Restriction
  on property: may_prevent
  some values from: AIDS-Related Opportunistic Infections [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Candidiasis, Chronic Mucocutaneous [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Candidiasis, Cutaneous [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Candidiasis, Oral [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Candidiasis, Vulvovaginal [Disease/Finding]
Display_Name: NYSTATIN
FDA_UNII: BDF1O1C72E
Level: Ingredient
NUI: N0000145961
RxNorm_CUI: 7597
RxNorm_Name: Nystatin
Status: Active
UMLS_CUI: C0028741
VANDF_Record: <VANDF_Record>50.416^173^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>173</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^84^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>84</VA_IEN>
VUID: 4017580
code: C17778
imported from: NDF-RT.owl

CALCIUM
type: Class
subclass of: C [Preparations]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Calcium [Chemical/Ingredient]
Display_Name: CALCIUM
FDA_UNII: SY7Q814VUP
Level: Ingredient
NUI: N0000146031
RxNorm_CUI: 1895
RxNorm_Name: Calcium
Status: Active
UMLS_CUI: C0006675
VANDF_Record: <VANDF_Record>50.416^247^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>247</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^2120^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>2120</VA_IEN>
VUID: 4017652
code: C12018
imported from: NDF-RT.owl

MAGNESIUM
type: Class
subclass of: M [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Heart Block [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Hepatitis [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Kidney Failure [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Magnesium [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Enzyme Interactions [MoA]
subclass of: Restriction
  on property: has_MoA
  some values from: Electrolyte Activity [MoA]
subclass of: Restriction
  on property: has_MoA
  some values from: Acid-Base Activity [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Cellular Activity Alteration [PE]
subclass of: Restriction
  on property: may_prevent
  some values from: Magnesium Deficiency [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Magnesium Deficiency [Disease/Finding]
Display_Name: MAGNESIUM
Level: Ingredient
NUI: N0000146038
RxNorm_CUI: 6574
RxNorm_Name: Magnesium
Status: Active
UMLS_CUI: C0024467
VANDF_Record: <VANDF_Record>50.416^1298^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>1298</VA_IEN>
VANDF_Record: <VANDF_Record>50.416^255^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>255</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^2113^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>2113</VA_IEN>
VUID: 4017660
code: C16682
imported from: NDF-RT.owl

CHOLECALCIFEROL
type: Class
subclass of: C [Preparations]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Cholecalciferol [Chemical/Ingredient]
subclass of: Restriction
  on property: may_treat
  some values from: Cardiovascular Diseases [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Crohn Disease [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Kidney Failure, Chronic [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Lung Neoplasms [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Osteoporosis [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Psoriasis [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Skin Neoplasms [Disease/Finding]
Display_Name: CHOLECALCIFEROL
FDA_UNII: 1C6V77QF41
Level: Ingredient
NUI: N0000146043
RxNorm_CUI: 2418
RxNorm_Name: Cholecalciferol
Status: Active
UMLS_CUI: C0008318
VANDF_Record: <VANDF_Record>50.416^262^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>262</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^2967^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>2967</VA_IEN>
VUID: 4017667
code: C12772
imported from: NDF-RT.owl

CHLOROTHIAZIDE
type: Class
subclass of: C [Preparations]
subclass of: Restriction
  on property: CI_ChemClass
  some values from: Sulfonamides [Chemical/Ingredient]
subclass of: Restriction
  on property: CI_with
  some values from: Anuria [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Kidney Failure [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Pregnancy [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Chlorothiazide [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Small Ion Transport Pump Interactions [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Intravascular Volume [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Distal Tubule H+ Excretion [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Distal Tubule K+ Excretion [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Distal Tubule Na+ Excretion [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Blood Pressure [PE]
subclass of: Restriction
  on property: may_treat
  some values from: Edema [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Heart Failure [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Hypertension [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Nephrotic Syndrome [Disease/Finding]
Display_Name: CHLOROTHIAZIDE
FDA_UNII: 77W477J15H
Level: Ingredient
NUI: N0000146099
RxNorm_CUI: 2396
RxNorm_Name: Chlorothiazide
Status: Active
UMLS_CUI: C0008273
VANDF_Record: <VANDF_Record>50.416^326^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>326</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^128^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>128</VA_IEN>
VUID: 4017731
code: C12722
imported from: NDF-RT.owl

DEXTROSE
type: Class
subclass of: D [Preparations]
subclass of: Class
  intersection of: Restriction
    on property: CI_with
    some values from: Alcohol Withdrawal Delirium [Disease/Finding]
  intersection of: Restriction
    on property: CI_with
    some values from: Dehydration [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Food Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Hyperglycemia [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Intracranial Hemorrhages [Disease/Finding]
subclass of: Restriction
  on property: has_MoA
  some values from: Structural Macromolecules [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Glycogenesis [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Metabolic Rate [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Organic Ion Synthesis Alteration [PE]
subclass of: Restriction
  on property: may_treat
  some values from: Hypoglycemia [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Postoperative Complications [Disease/Finding]
Display_Name: DEXTROSE
FDA_UNII: IY9XDZ35W2
Level: Ingredient
NUI: N0000146124
RxNorm_CUI: 4850
RxNorm_Name: Glucose
Status: Active
UMLS_CUI: C0017725
VANDF_Record: <VANDF_Record>50.416^355^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>355</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^535^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>535</VA_IEN>
VUID: 4017760
code: C13652
imported from: NDF-RT.owl

CALCIUM CHLORIDE
type: Class
subclass of: CALCIUM
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Toxicity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Hypercalcemia [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Kidney Calculi [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Ventricular Fibrillation [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Calcium [Chemical/Ingredient]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Calcium Chloride [Chemical/Ingredient]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Cardiac Muscle Organized Electrical Activity [PE]
subclass of: Restriction
  on property: may_treat
  some values from: Heart Arrest [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Hyperkalemia [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Tetany [Disease/Finding]
Display_Name: CALCIUM CHLORIDE
FDA_UNII: M4I0D6VV5M
Level: Ingredient
NUI: N0000146424
RxNorm_CUI: 1901
RxNorm_Name: Calcium Chloride
Status: Active
UMLS_CUI: C0006686
VANDF_Record: <VANDF_Record>50.416^682^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>682</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^405^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>405</VA_IEN>
VUID: 4018085
code: C12048
imported from: NDF-RT.owl

METOLAZONE
type: Class
subclass of: M [Preparations]
subclass of: Restriction
  on property: CI_ChemClass
  some values from: Sulfonamides [Chemical/Ingredient]
subclass of: Restriction
  on property: CI_with
  some values from: Anuria [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Coma [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Kidney Failure [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Pregnancy [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Metolazone [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Small Ion Transport Pump Interactions [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Intravascular Volume [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Distal Tubule H+ Excretion [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Distal Tubule K+ Excretion [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Distal Tubule Na+ Excretion [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Blood Pressure [PE]
subclass of: Restriction
  on property: may_treat
  some values from: Edema [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Heart Failure [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Hypertension [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Nephrotic Syndrome [Disease/Finding]
Display_Name: METOLAZONE
FDA_UNII: TZ7V40X7VX
Level: Ingredient
NUI: N0000146498
RxNorm_CUI: 6916
RxNorm_Name: Metolazone
Status: Active
UMLS_CUI: C0025854
VANDF_Record: <VANDF_Record>50.416^758^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>758</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^481^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>481</VA_IEN>
VUID: 4018161
code: C17234
imported from: NDF-RT.owl

MAGNESIUM CHLORIDE
type: Class
subclass of: MAGNESIUM
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Heart Block [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Hepatitis [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Kidney Failure [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Magnesium [Chemical/Ingredient]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Magnesium Chloride [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Enzyme Interactions [MoA]
subclass of: Restriction
  on property: has_MoA
  some values from: Electrolyte Activity [MoA]
subclass of: Restriction
  on property: has_MoA
  some values from: Acid-Base Activity [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Cellular Activity Alteration [PE]
subclass of: Restriction
  on property: may_prevent
  some values from: Magnesium Deficiency [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Magnesium Deficiency [Disease/Finding]
Display_Name: MAGNESIUM CHLORIDE
FDA_UNII: 02F3473H9O
Level: Ingredient
NUI: N0000146546
RxNorm_CUI: 6579
RxNorm_Name: Magnesium Chloride
Status: Active
UMLS_CUI: C0024472
VANDF_Record: <VANDF_Record>50.416^810^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>810</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^1464^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>1464</VA_IEN>
VUID: 4018213
code: C16702
imported from: NDF-RT.owl

DOPAMINE HYDROCHLORIDE
type: Class
subclass of: DOPAMINE
subclass of: Restriction
  on property: CI_ChemClass
  some values from: Sulfites [Chemical/Ingredient]
subclass of: Restriction
  on property: CI_with
  some values from: Pheochromocytoma [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Ventricular Fibrillation [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Dopamine Hydrochloride [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Dopamine Agonists [MoA]
subclass of: Restriction
  on property: has_MoA
  some values from: Adrenergic Agonists [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Positive Chronotropy [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Positive Inotropy [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Renal Arterial Vasodilation [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Systemic Arterial Vasoconstriction [PE]
subclass of: Restriction
  on property: may_treat
  some values from: Bradycardia [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Cardiac Output, Low [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Heart Block [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Kidney Diseases [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Shock [Disease/Finding]
Display_Name: DOPAMINE HYDROCHLORIDE
FDA_UNII: 7L3E358N9L
Level: Ingredient
NUI: N0000146968
RxNorm_CUI: 82010
RxNorm_Name: Dopamine Hydrochloride
Status: Active
UMLS_CUI: C0282151
VANDF_Record: <VANDF_Record>50.416^1257^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>1257</VA_IEN>
VUID: 4018656
code: C14014
imported from: NDF-RT.owl

SODIUM LACTATE
type: Class
subclass of: S [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Sodium Lactate [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Electrolyte Activity [MoA]
subclass of: Restriction
  on property: has_MoA
  some values from: Acid-Base Activity [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Renal HCO3- Excretion [PE]
subclass of: Restriction
  on property: may_treat
  some values from: Acidosis [Disease/Finding]
Display_Name: SODIUM LACTATE
FDA_UNII: TU7HW0W0QT
Level: Ingredient
NUI: N0000147000
RxNorm_CUI: 56489
RxNorm_Name: Sodium Lactate
Status: Active
UMLS_CUI: C0142874
VANDF_Record: <VANDF_Record>50.416^1292^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>1292</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^1011^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>1011</VA_IEN>
VUID: 4018691
code: C20002
imported from: NDF-RT.owl

VITAMIN K
type: Class
subclass of: V [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Vitamin K [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Unknown Cellular or Molecular Interaction [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Coagulation Factor Activity [PE]
subclass of: Restriction
  on property: may_prevent
  some values from: Hypoprothrombinemias [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Abnormalities, Drug-Induced [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Hypoprothrombinemias [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Infant, Premature, Diseases [Disease/Finding]
Display_Name: VITAMIN K
Level: Ingredient
NUI: N0000147258
RxNorm_CUI: 11258
RxNorm_Name: Vitamin K
Status: Active
UMLS_CUI: C0042878
VANDF_Record: <VANDF_Record>50.416^1586^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>1586</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^4606^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>4606</VA_IEN>
VUID: 4018981
code: C21516
imported from: NDF-RT.owl

DIGOXIN IMMUNE FAB (OVINE)
type: Class
subclass of: DIGOXIN IMMUNE FAB
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: digoxin antibodies Fab fragments [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Antibody Interactions [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Hematologic Activity Alteration [PE]
subclass of: Restriction
  on property: may_prevent
  some values from: Abnormalities, Drug-Induced [Disease/Finding]
subclass of: Restriction
  on property: may_prevent
  some values from: Drug Toxicity [Disease/Finding]
subclass of: Restriction
  on property: may_prevent
  some values from: Overdose [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Drug Toxicity [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Overdose [Disease/Finding]
Display_Name: DIGOXIN IMMUNE FAB (OVINE)
Level: Ingredient
NUI: N0000147621
RxNorm_CUI: 203223
RxNorm_Name: digoxin antibodies Fab fragments
Status: Active
UMLS_CUI: C0700607
VANDF_Record: <VANDF_Record>50.416^2115^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>2115</VA_IEN>
VUID: 4019501
code: C13778
imported from: NDF-RT.owl

GLUCOSE
type: Class
subclass of: G [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Hyperglycemia [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Glucose [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Structural Macromolecules [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Glycogenesis [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Metabolic Rate [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Organic Ion Synthesis Alteration [PE]
subclass of: Restriction
  on property: may_treat
  some values from: Hypoglycemia [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Postoperative Complications [Disease/Finding]
Display_Name: GLUCOSE
FDA_UNII: IY9XDZ35W2
Level: Ingredient
NUI: N0000147647
RxNorm_CUI: 4850
RxNorm_Name: Glucose
Status: Active
UMLS_CUI: C0017725
VANDF_Record: <VANDF_Record>50.416^2156^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>2156</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^2205^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>2205</VA_IEN>
VUID: 4019541
code: C15102
imported from: NDF-RT.owl

DOBUTAMINE
type: Class
subclass of: D [Preparations]
subclass of: Restriction
  on property: CI_ChemClass
  some values from: Sulfites [Chemical/Ingredient]
subclass of: Restriction
  on property: CI_with
  some values from: Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Discrete Subaortic Stenosis [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Dobutamine [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Adrenergic beta1-Agonists [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Positive Chronotropy [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Positive Inotropy [PE]
subclass of: Restriction
  on property: may_treat
  some values from: Cardiac Output, Low [Disease/Finding]
Display_Name: DOBUTAMINE
FDA_UNII: 3S12J47372
Level: Ingredient
NUI: N0000147822
RxNorm_CUI: 3616
RxNorm_Name: Dobutamine
Status: Active
UMLS_CUI: C0012963
VANDF_Record: <VANDF_Record>50.416^2349^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>2349</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^77^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>77</VA_IEN>
VUID: 4019730
code: C13966
imported from: NDF-RT.owl

DOPAMINE
type: Class
subclass of: D [Preparations]
subclass of: Restriction
  on property: CI_ChemClass
  some values from: Sulfites [Chemical/Ingredient]
subclass of: Restriction
  on property: CI_with
  some values from: Pheochromocytoma [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Ventricular Fibrillation [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Dopamine [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Dopamine Agonists [MoA]
subclass of: Restriction
  on property: has_MoA
  some values from: Adrenergic Agonists [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Positive Chronotropy [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Positive Inotropy [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Renal Arterial Vasodilation [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Systemic Arterial Vasoconstriction [PE]
subclass of: Restriction
  on property: may_treat
  some values from: Bradycardia [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Cardiac Output, Low [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Heart Block [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Kidney Diseases [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Shock [Disease/Finding]
Display_Name: DOPAMINE
FDA_UNII: VTD58H1Z2X
Level: Ingredient
NUI: N0000147825
RxNorm_CUI: 3628
RxNorm_Name: Dopamine
Status: Active
UMLS_CUI: C0013030
VANDF_Record: <VANDF_Record>50.416^2352^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>2352</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^981^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>981</VA_IEN>
VUID: 4019733
code: C14012
imported from: NDF-RT.owl

SULBACTAM
type: Class
subclass of: S [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Sulbactam [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: beta Lactamase Inhibitors [MoA]
Display_Name: SULBACTAM
FDA_UNII: S4TF6I2330
Level: Ingredient
NUI: N0000148022
RxNorm_CUI: 10167
RxNorm_Name: Sulbactam
Status: Active
UMLS_CUI: C0038665
VANDF_Record: <VANDF_Record>50.416^2562^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>2562</VA_IEN>
VUID: 4019937
code: C20432
imported from: NDF-RT.owl

FOSCARNET
type: Class
subclass of: F [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Kidney Failure [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Foscarnet [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Reverse Transcriptase Inhibitors [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased DNA Replication [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Protein Synthesis [PE]
subclass of: Restriction
  on property: may_treat
  some values from: Cytomegalovirus Infections [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Herpes Genitalis [Disease/Finding]
Display_Name: FOSCARNET
FDA_UNII: 364P9RVW4X
Level: Ingredient
NUI: N0000148246
RxNorm_CUI: 33562
RxNorm_Name: Foscarnet
Status: Active
UMLS_CUI: C0070895
VANDF_Record: <VANDF_Record>50.416^3175^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>3175</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^2700^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>2700</VA_IEN>
VUID: 4020530
code: C14900
imported from: NDF-RT.owl

TORSEMIDE
type: Class
subclass of: T [Preparations]
subclass of: Restriction
  on property: CI_ChemClass
  some values from: Sulfonamides [Chemical/Ingredient]
subclass of: Restriction
  on property: CI_with
  some values from: Anuria [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Dehydration [Disease/Finding]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: torsemide [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Small Ion Transport Pump Interactions [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Intravascular Volume [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Loop of Henle Ca++ Excretion [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Loop of Henle Cl- Excretion [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Loop of Henle K+ Excretion [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Loop of Henle Mg++ Excretion [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Increased Loop of Henle Na+ Excretion [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Blood Pressure [PE]
subclass of: Restriction
  on property: has_PK
  some values from: Hepatic Metabolism [PK]
subclass of: Restriction
  on property: has_PK
  some values from: Renal Excretion [PK]
subclass of: Restriction
  on property: may_treat
  some values from: Ascites [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Edema [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Heart Failure [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Hypertension [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Kidney Failure, Acute [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Kidney Failure, Chronic [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Liver Cirrhosis [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Nephrotic Syndrome [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Pulmonary Edema [Disease/Finding]
Display_Name: TORSEMIDE
FDA_UNII: W31X2H97FB
Level: Ingredient
NUI: N0000148359
RxNorm_CUI: 38413
RxNorm_Name: torsemide
Status: Active
UMLS_CUI: C0076840
VANDF_Record: <VANDF_Record>50.416^3507^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>3507</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^3182^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>3182</VA_IEN>
VUID: 4020851
code: C21024
imported from: NDF-RT.owl

TACROLIMUS
type: Class
subclass of: T [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Tacrolimus [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Unknown Cellular or Molecular Interaction [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Cellular Growth Phase Arrest [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Cytokine Production [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased T Lymphocyte Production [PE]
subclass of: Restriction
  on property: may_prevent
  some values from: Graft vs Host Disease [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Dermatitis, Atopic [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Graft vs Host Disease [Disease/Finding]
Display_Name: TACROLIMUS
FDA_UNII: WM0HAQ4WNM
Level: Ingredient
NUI: N0000148372
RxNorm_CUI: 42316
RxNorm_Name: Tacrolimus
Status: Active
UMLS_CUI: C0085149
VANDF_Record: <VANDF_Record>50.416^3525^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>3525</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^3228^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>3228</VA_IEN>
VUID: 4020868
code: C20568
imported from: NDF-RT.owl

CISATRACURIUM BESYLATE
type: Class
subclass of: CISATRACURIUM
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: cisatracurium [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Competitive Cholinergic Nicotinic Antagonists [MoA]
subclass of: Restriction
  on property: has_MoA
  some values from: Cholinergic Neuromuscular Nicotinic Antagonists [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Striated Muscle Contraction [PE]
subclass of: Restriction
  on property: induces
  some values from: Muscle Hypotonia [Disease/Finding]
subclass of: Restriction
  on property: induces
  some values from: Unconsciousness [Disease/Finding]
Display_Name: CISATRACURIUM BESYLATE
FDA_UNII: 80YS8O1MBS
Level: Ingredient
NUI: N0000148433
RxNorm_CUI: 136561
RxNorm_Name: cisatracurium besylate
Status: Active
UMLS_CUI: C0530105
VANDF_Record: <VANDF_Record>50.416^3623^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>3623</VA_IEN>
VUID: 4020957
code: C12890
imported from: NDF-RT.owl

BASILIXIMAB
type: Class
subclass of: B [Preparations]
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: basiliximab [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Interleukin 2 Receptor Antagonists [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Cytokine Activity [PE]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Lymphocyte Cell Production [PE]
subclass of: Restriction
  on property: may_prevent
  some values from: Graft vs Host Disease [Disease/Finding]
Display_Name: BASILIXIMAB
FDA_UNII: 9927MT646M
Level: Ingredient
NUI: N0000148568
RxNorm_CUI: 196102
RxNorm_Name: basiliximab
Status: Active
UMLS_CUI: C0676831
VANDF_Record: <VANDF_Record>50.416^3784^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>3784</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^3509^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>3509</VA_IEN>
VUID: 4021113
code: C11516
imported from: NDF-RT.owl

NYSTATIN 100000UNT/ML SUSP,ORAL [VA Product]
type: Class
subclass of: [AM700] ANTIFUNGALS
subclass of: NYSTATIN
subclass of: Restriction
  on property: CI_with
  some values from: Drug Hypersensitivity [Disease/Finding]
subclass of: Restriction
  on property: has_Ingredient
  some values from: Nystatin [Chemical/Ingredient]
subclass of: Restriction
  on property: has_MoA
  some values from: Ergosterol Synthesis Inhibitors [MoA]
subclass of: Restriction
  on property: has_PE
  some values from: Decreased Cell Wall Integrity [PE]
subclass of: Restriction
  on property: may_prevent
  some values from: Candidiasis, Cutaneous [Disease/Finding]
subclass of: Restriction
  on property: may_prevent
  some values from: AIDS-Related Opportunistic Infections [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Candidiasis, Chronic Mucocutaneous [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Candidiasis, Cutaneous [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Candidiasis, Oral [Disease/Finding]
subclass of: Restriction
  on property: may_treat
  some values from: Candidiasis, Vulvovaginal [Disease/Finding]
type: NamedIndividual
Level: VA Product
Strength: 100000
RxNorm_Name: Nystatin 100000 UNT/ML Oral Suspension
imported from: NDF-RT.owl
Units: UNIT/ML
VANDF_Record: <VANDF_Record>50.68^897^</VANDF_Record><VA_File>50.68</VA_File><VA_IEN>897</VA_IEN>
VUID: 4001505
Display_Name: NYSTATIN 100000UNT/ML SUSP,ORAL
NUI: N0000149693
product component qualifier: <Product_Component>NYSTATIN</Product_Component><Strength>100000</Strength><Unit>UNIT/ML</Unit><Unit>UNT/ML</Unit><VA.IEN>173</VA.IEN>
UMLS_CUI: C0979080
VA_National_Formulary_Name: NYSTATIN SUSP
RxNorm_CUI: 312055
VANDF_Record: <VANDF_Record>50.68^902^Inactive</VANDF_Record><VA_File>50.68</VA_File><VA_IEN>902</VA_IEN><VA_Status>Inactive</VA_Status>
code: C47624
Status: Active
Print_Name: NYSTATIN 100000 UNT/ML SUSP
Product_Component: NYSTATIN

DIANEAL PD-2/DEXTROSE 2.5% SOLN [VA Product]
type: Class
subclass of: DEXTROSE/PERITONEAL DIALYSIS SOLUTION
subclass of: [IR200] PERITONEAL DIALYSIS SOLUTIONS
type: NamedIndividual
product component qualifier: <Product_Component>MAGNESIUM CHLORIDE</Product_Component> 5.08 MG/100ML <VA.IEN>810</VA.IEN>
Product_Component: MAGNESIUM CHLORIDE
product component qualifier: <Product_Component>CALCIUM CHLORIDE</Product_Component> 25.7 MG/100ML <VA.IEN>682</VA.IEN>
RxNorm_Name: Calcium Chloride 0.00014 MEQ/ML / Glucose 1 MG/ML / Magnesium Chloride 0.0000245 MEQ/ML / Sodium Chloride 0.00368 MEQ/ML / Sodium Lactate 0.0016 MEQ/ML Intraperitoneal Solution [Dianeal PD-2/2.5]
UMLS_CUI: C1829021
product component qualifier: <Product_Component>DEXTROSE</Product_Component><Strength>2.5</Strength><Unit>GM/100ML</Unit><VA.IEN>355</VA.IEN>
Display_Name: DIANEAL PD-2/DEXTROSE 2.5% SOLN
NUI: N0000154189
Product_Component: DEXTROSE
Product_Component: CALCIUM CHLORIDE
Status: Active
product component qualifier: <Product_Component>SODIUM CHLORIDE</Product_Component> 538 MG/100ML <VA.IEN>35</VA.IEN>
VA_National_Formulary_Name: DEXTROSE/PERITONEAL DIALYSIS SOLUTION SOLN
imported from: NDF-RT.owl
RxNorm_CUI: 800064
Level: VA Product
code: C39204
product component qualifier: <Product_Component>SODIUM LACTATE</Product_Component> 448 MG/100ML <VA.IEN>1292</VA.IEN>
VANDF_Record: <VANDF_Record>50.68^5634^</VANDF_Record><VA_File>50.68</VA_File><VA_IEN>5634</VA_IEN>
VUID: 4006159
Product_Component: SODIUM CHLORIDE
Product_Component: SODIUM LACTATE

Thiazides [Chemical/Ingredient]
type: Class
subclass of: Sulfur Compounds [Chemical/Ingredient]
Display_Name: Thiazides
MeSH_CUI: M0471776
MeSH_DUI: D049971
MeSH_Definition: Heterocyclic compounds with SULFUR and NITROGEN in the ring. This term commonly refers to the BENZOTHIADIAZINES that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS and are used as DIURETICS.
MeSH_Name: Thiazides
NUI: N0000166469
RxNorm_CUI: 141801
UMLS_CUI: C0541746
code: C7757382887769
imported from: NDF-RT.owl

Immunoglobulin Fab Fragments [Chemical/Ingredient]
type: Class
subclass of: Immunoglobulin Fragments [Chemical/Ingredient]
Display_Name: Immunoglobulin Fab Fragments
MeSH_CUI: M0011126
MeSH_DUI: D007140
MeSH_Definition: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
MeSH_Name: Immunoglobulin Fab Fragments
NUI: N0000169389
RxNorm_CUI: 5724
Synonym: Fab Fragments
Synonym: Fab Immunoglobulin Fragments
Synonym: Immunoglobulin Fab Fragment
Synonym: Immunoglobulins, Fab
Synonym: Immunoglobulins, Fab Fragment
UMLS_CUI: C0021031
code: C7761971851729
imported from: NDF-RT.owl

Renal Insufficiency [Disease/Finding]
type: Class
subclass of: Kidney Diseases [Disease/Finding]
Display_Name: Renal Insufficiency
MeSH_CUI: M0480487
MeSH_DUI: D051437
MeSH_Definition: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
MeSH_Name: Renal Insufficiency
NUI: N0000171642
RxNorm_CUI: 1026620
Synonym: Kidney Insufficiency
UMLS_CUI: C1565489
code: C7769506319378
imported from: NDF-RT.owl

Renal Insufficiency, Chronic [Disease/Finding]
type: Class
subclass of: Renal Insufficiency [Disease/Finding]
Display_Name: Renal Insufficiency, Chronic
MeSH_CUI: M0480472
MeSH_DUI: D051436
MeSH_Definition: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
MeSH_Name: Renal Insufficiency, Chronic
NUI: N0000171643
RxNorm_CUI: 1025359
SNOMED_CID: 236425005
Synonym: Chronic Kidney Insufficiency
Synonym: Chronic Renal Insufficiency
Synonym: Kidney Insufficiency, Chronic
UMLS_CUI: C0403447
code: C7769506596229
imported from: NDF-RT.owl

Quinazolinones [Chemical/Ingredient]
type: Class
subclass of: Quinazolines [Chemical/Ingredient]
Display_Name: Quinazolinones
MeSH_CUI: M0490629
MeSH_DUI: D052999
MeSH_Definition: Chemicals with two conjoined aromatic rings incorporating two nitrogen atoms and one of the carbons oxidized with a keto oxygen.
MeSH_Name: Quinazolinones
NUI: N0000175104
RxNorm_CUI: 657853
UMLS_CUI: C1720912
code: C25677206981334
imported from: NDF-RT.owl

Diuresis Alteration [PE]
type: Class
subclass of: Renal/Urological Activity Alteration [PE]
Display_Name: Diuresis Alteration
NUI: N0000175358
RxNorm_CUI: 990564
UMLS_CUI: C2266869
code: C634741
imported from: NDF-RT.owl

Increased Diuresis [PE]
type: Class
subclass of: Diuresis Alteration [PE]
Display_Name: Increased Diuresis
NUI: N0000175359
RxNorm_CUI: 985593
Synonym: Diuretic Activity
UMLS_CUI: C2266870
code: C634742
imported from: NDF-RT.owl

Increased Diuresis at Loop of Henle [PE]
type: Class
subclass of: Increased Diuresis [PE]
Display_Name: Increased Diuresis at Loop of Henle
NUI: N0000175366
RxNorm_CUI: 985088
UMLS_CUI: C2266877
code: C634749
imported from: NDF-RT.owl

Cholinergic Interactions [MoA]
type: Class
subclass of: Receptor Interactions [MoA]
Display_Name: Cholinergic Interactions
NUI: N0000175368
RxNorm_CUI: 987379
UMLS_CUI: C2266879
code: C634751
imported from: NDF-RT.owl

Cholinergic Antagonists [MoA]
type: Class
subclass of: Cholinergic Interactions [MoA]
Display_Name: Cholinergic Antagonists
NUI: N0000175370
RxNorm_CUI: 1030384
UMLS_CUI: C2757022
code: C634753
imported from: NDF-RT.owl

Decreased Immunologic Activity [PE]
type: Class
subclass of: Immunologic Activity Alteration [PE]
Display_Name: Decreased Immunologic Activity
NUI: N0000175550
RxNorm_CUI: 989722
Synonym: Immune Suppression
Synonym: Immune System Suppression
Synonym: Immunologic Suppression
Synonym: Immunosuppression
UMLS_CUI: C1373218
code: C634943
imported from: NDF-RT.owl

Competitive Cholinergic Nicotinic Antagonists [MoA]
type: Class
subclass of: Cholinergic Nicotinic Antagonists [MoA]
Display_Name: Competitive Cholinergic Nicotinic Antagonists
NUI: N0000175703
RxNorm_CUI: 991928
UMLS_CUI: C2917208
code: C635109
imported from: NDF-RT.owl

Cholinergic Neuromuscular Nicotinic Antagonists [MoA]
type: Class
subclass of: Cholinergic Nicotinic Antagonists [MoA]
Display_Name: Cholinergic Neuromuscular Nicotinic Antagonists
NUI: N0000175718
RxNorm_CUI: 991927
UMLS_CUI: C2917207
code: C635124
imported from: NDF-RT.owl

Coagulation Activity Alteration [PE]
type: Class
subclass of: Hemostasis Alteration [PE]
Display_Name: Coagulation Activity Alteration
NUI: N0000175977
RxNorm_CUI: 991697
UMLS_CUI: C2917139
code: C635431
imported from: NDF-RT.owl

Increased Coagulation Activity [PE]
type: Class
subclass of: Coagulation Activity Alteration [PE]
Display_Name: Increased Coagulation Activity
NUI: N0000175979
RxNorm_CUI: 992037
Synonym: Pro-coagulation
Synonym: Pro-coagulation Activity
Synonym: Procoagulation
Synonym: Procoagulation Activity
UMLS_CUI: C2917275
code: C635433
imported from: NDF-RT.owl

ECULIZUMAB
type: Class
subclass of: E [Preparations]
subclass of: Restriction
  on property: has_Ingredient
  some values from: eculizumab [Chemical/Ingredient]
Display_Name: ECULIZUMAB
FDA_UNII: A3ULP0F556
Level: Ingredient
NUI: N0000176091
RxNorm_CUI: 591781
RxNorm_Name: eculizumab
Status: Active
UMLS_CUI: C1541483
VANDF_Record: <VANDF_Record>50.416^4452^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>4452</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^4236^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>4236</VA_IEN>
VUID: 4026032
code: C50.416.4452
imported from: NDF-RT.owl

Blood Pressure Alteration [PE]
type: Class
subclass of: Cardiovascular Activity Alteration [PE]
Display_Name: Blood Pressure Alteration
NUI: N0000178476
RxNorm_CUI: 991626
UMLS_CUI: C2917124
code: C637932
imported from: NDF-RT.owl

Decreased Blood Pressure [PE]
type: Class
subclass of: Blood Pressure Alteration [PE]
Display_Name: Decreased Blood Pressure
NUI: N0000178477
RxNorm_CUI: 991700
UMLS_CUI: C2917141
code: C637933
imported from: NDF-RT.owl

Azabicyclo Compounds [Chemical/Ingredient]
type: Class
subclass of: Bicyclo Compounds, Heterocyclic [Chemical/Ingredient]
subclass of: Aza Compounds [Chemical/Ingredient]
Display_Name: Azabicyclo Compounds
MeSH_CUI: M0499252
MeSH_DUI: D053961
MeSH_Definition: Bicyclic bridged compounds that contain a nitrogen which has three bonds. The nomenclature indicates the number of atoms in each path around the rings, such as [2.2.2] for three equal length paths. Some members are TROPANES and BETA LACTAMS.
MeSH_Name: Azabicyclo Compounds
NUI: N0000178749
RxNorm_CUI: 737880
UMLS_CUI: C1955840
code: CMSHM0499252
imported from: NDF-RT.owl

Dopamine Hydrochloride [Chemical/Ingredient]
type: Class
subclass of: Dopamine [Chemical/Ingredient]
Display_Name: Dopamine Hydrochloride
MeSH_CUI: M0006757
MeSH_DUI: D004298
MeSH_Name: Dopamine Hydrochloride
NUI: N0000179412
RxNorm_CUI: 82010
RxNorm_Name: Dopamine Hydrochloride
UMLS_CUI: C0282151
code: CMSHM0006757
imported from: NDF-RT.owl

digoxin antibodies Fab fragments [Chemical/Ingredient]
type: Class
subclass of: Immunoglobulin Fab Fragments [Chemical/Ingredient]
Display_Name: digoxin antibodies Fab fragments
MeSH_CUI: M0143483
MeSH_DUI: C050199
MeSH_Name: digoxin antibodies Fab fragments
NUI: N0000179656
RxNorm_CUI: 203223
RxNorm_Name: digoxin antibodies Fab fragments
Synonym: digoxin immune Fab
UMLS_CUI: C0700607
code: CMSHM0143483
imported from: NDF-RT.owl

eculizumab [Chemical/Ingredient]
type: Class
subclass of: Antibodies, Monoclonal [Chemical/Ingredient]
Display_Name: eculizumab
MeSH_CUI: M0461005
MeSH_DUI: C481642
MeSH_Name: eculizumab
NUI: N0000179786
RxNorm_CUI: 591781
RxNorm_Name: eculizumab
UMLS_CUI: C1541483
code: CMSHM0461005
imported from: NDF-RT.owl

Nephrolithiasis [Disease/Finding]
type: Class
subclass of: Kidney Diseases [Disease/Finding]
subclass of: Urolithiasis [Disease/Finding]
Display_Name: Nephrolithiasis
MeSH_CUI: M0476604
MeSH_DUI: D053040
MeSH_Definition: Formation of stones in the KIDNEY.
MeSH_Name: Nephrolithiasis
NUI: N0000181137
RxNorm_CUI: 1026053
UMLS_CUI: C0392525
code: CMSHM0476604
imported from: NDF-RT.owl

Urolithiasis [Disease/Finding]
type: Class
subclass of: Urologic Diseases [Disease/Finding]
Display_Name: Urolithiasis
MeSH_CUI: M0022363
MeSH_DUI: D052878
MeSH_Definition: Formation of stones in any part of the URINARY TRACT, usually in the KIDNEY; URINARY BLADDER; or the URETER.
MeSH_Name: Urolithiasis
NUI: N0000181149
RxNorm_CUI: 1025826
Synonym: Urinary Lithiasis
UMLS_CUI: C0451641
code: CMSHM0022363
imported from: NDF-RT.owl

Female Urogenital Diseases [Disease/Finding]
type: Class
subclass of: Female Urogenital Diseases and Pregnancy Complications [Disease/Finding]
Display_Name: Female Urogenital Diseases
MeSH_CUI: M0489295
MeSH_DUI: D052776
MeSH_Definition: Pathological processes of the female URINARY TRACT and the reproductive system (GENITALIA, FEMALE).
MeSH_Name: Female Urogenital Diseases
NUI: N0000181236
RxNorm_CUI: 1024696
Synonym: Female Genitourinary Diseases
UMLS_CUI: C1720887
code: CMSHM0489295
imported from: NDF-RT.owl

Acute Kidney Injury [Disease/Finding]
type: Class
subclass of: Renal Insufficiency [Disease/Finding]
Display_Name: Acute Kidney Injury
MeSH_CUI: M0541307
MeSH_DUI: D058186
MeSH_Definition: Abrupt reduction in kidney function defined as an absolute increase in serum CREATININE of more than or equal to 0.3. mg/dl, a percentage increase in serum creatinine of more than or equal to 50%, or a reduction in urine output. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
MeSH_Name: Acute Kidney Injury
NUI: N0000182224
RxNorm_CUI: 1085890
Synonym: Acute Renal Injury
UMLS_CUI: C2609414
code: CMSHM0541307
imported from: NDF-RT.owl

BELATACEPT
type: Class
subclass of: B [Preparations]
Display_Name: BELATACEPT
Level: Ingredient
NUI: N0000182970
RxNorm_CUI: 1148754
Status: Active
VANDF_Record: <VANDF_Record>50.416^4763^</VANDF_Record><VA_File>50.416</VA_File><VA_IEN>4763</VA_IEN>
VANDF_Record: <VANDF_Record>50.6^4654^</VANDF_Record><VA_File>50.6</VA_File><VA_IEN>4654</VA_IEN>
VUID: 4030905
code: C50.416^4763^
imported from: NDF-RT.owl

RIT1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CNNM2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CFB
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SALL1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SCNN1B
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SCNN1G
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SDCCAG8
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BMPR2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SGPL1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SIX5
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC12A1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC12A3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BRAF
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC2A2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BRCA2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC34A1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC35A1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC4A1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC4A4
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC5A2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC9A3R1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SMARCAL1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SOS1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SOS2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SOX18
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TBX18
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CEP55
type: Class
subclass of: SO_0000704
imported from: mondo.owl

HNF1B
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TFE3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

THBD
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TP53
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TREX1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TRPC6
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TSC1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TSHR
type: Class
subclass of: SO_0000704
imported from: mondo.owl

UMOD
type: Class
subclass of: SO_0000704
imported from: mondo.owl

VPS33B
type: Class
subclass of: SO_0000704
imported from: mondo.owl

WT1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

XDH
type: Class
subclass of: SO_0000704
imported from: mondo.owl

XRCC2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

C3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ARL6
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NEK8
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NPHS2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC2A9
type: Class
subclass of: SO_0000704
imported from: mondo.owl

IFT122
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ADAMTS13
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CA2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ANLN
type: Class
subclass of: SO_0000704
imported from: mondo.owl

WNK1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

WNK4
type: Class
subclass of: SO_0000704
imported from: mondo.owl

AMN
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DNAJB11
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PIGT
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CAV1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SETBP1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FCGR2C
type: Class
subclass of: SO_0000704
imported from: mondo.owl

IFT52
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TP63
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CD151
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MAGED2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TRIM32
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NLRP3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BSND
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ACTN4
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SCARB2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ZNF423
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PUF60
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PLCE1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SARS2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DACT1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TRAF3IP1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

INVS
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CEP83
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC22A12
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TRPM6
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DCDC2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MOCOS
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SEC61A1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

WDR19
type: Class
subclass of: SO_0000704
imported from: mondo.owl

HPSE2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CECR
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CENPF
type: Class
subclass of: SO_0000704
imported from: mondo.owl

IFT27
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NUP205
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CRB2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BBS7
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MMAA
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MAGI2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CORIN
type: Class
subclass of: SO_0000704
imported from: mondo.owl

COQ8B
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NPHP4
type: Class
subclass of: SO_0000704
imported from: mondo.owl

KIF14
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MMAB
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CHRM3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

EIF2AK4
type: Class
subclass of: SO_0000704
imported from: mondo.owl

KIAA0586
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TTC8
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CLCN5
type: Class
subclass of: SO_0000704
imported from: mondo.owl

COQ6
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CLCNKB
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CLDN10
type: Class
subclass of: SO_0000704
imported from: mondo.owl

VIPAS39
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CLDN16
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CLDN19
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BRIP1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FANCL
type: Class
subclass of: SO_0000704
imported from: mondo.owl

LRIG2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DSE
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ADCY10
type: Class
subclass of: SO_0000704
imported from: mondo.owl

IFT74
type: Class
subclass of: SO_0000704
imported from: mondo.owl

POU6F2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DYNC2I1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

COL4A1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

COL4A3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

COL4A5
type: Class
subclass of: SO_0000704
imported from: mondo.owl

COPA
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX26
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FAM20A
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC16A12
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ALG8
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FREM1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CREBBP
type: Class
subclass of: SO_0000704
imported from: mondo.owl

STOX1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

INF2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLX4
type: Class
subclass of: SO_0000704
imported from: mondo.owl

B9D1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CHST14
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DYNC2LI1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CFHR5
type: Class
subclass of: SO_0000704
imported from: mondo.owl

UBE2T
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TMEM216
type: Class
subclass of: SO_0000704
imported from: mondo.owl

HOGA1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CTNS
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CUBN
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CUL3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FANCI
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TTC21B
type: Class
subclass of: SO_0000704
imported from: mondo.owl

OFD1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TCTN2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CYP11B1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CYP24A1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PALB2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BBS10
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DZIP1L
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BBS12
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CEP120
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ANKS6
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FLCN
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC6A19
type: Class
subclass of: SO_0000704
imported from: mondo.owl

WDPCP
type: Class
subclass of: SO_0000704
imported from: mondo.owl

XPNPEP3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BBIP1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DYNC2I2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TMEM67
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GLIS3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DGKE
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DHCR7
type: Class
subclass of: SO_0000704
imported from: mondo.owl

B9D2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DIS3L2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

IQCB1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NUP93
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CEP290
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DSTYK
type: Class
subclass of: SO_0000704
imported from: mondo.owl

IFT140
type: Class
subclass of: SO_0000704
imported from: mondo.owl

RPGRIP1L
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FAN1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CEP164
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ERGIC1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

WDR35
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CC2D2A
type: Class
subclass of: SO_0000704
imported from: mondo.owl

IFT80
type: Class
subclass of: SO_0000704
imported from: mondo.owl

KANK2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GLIS2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MAPKBP1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

DNASE1L3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

IFT43
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NUP107
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BBS9
type: Class
subclass of: SO_0000704
imported from: mondo.owl

IFT172
type: Class
subclass of: SO_0000704
imported from: mondo.owl

EGF
type: Class
subclass of: SO_0000704
imported from: mondo.owl

EHHADH
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ELN
type: Class
subclass of: SO_0000704
imported from: mondo.owl

EMP2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

EP300
type: Class
subclass of: SO_0000704
imported from: mondo.owl

AGXT
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ERCC4
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FAH
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FANCA
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FANCB
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FANCC
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FANCD2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FANCE
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FANCF
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FANCG
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FGF20
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FGFR3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FIBP
type: Class
subclass of: SO_0000704
imported from: mondo.owl

TMEM231
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FN1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

FXYD2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

G6PC1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SLC37A4
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GALE
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GALK1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GALT
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GANAB
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ALDOB
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GATA3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GDF1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ALMS1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GLA
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GLI3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GNAS
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GPC3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

GRHPR
type: Class
subclass of: SO_0000704
imported from: mondo.owl

H19
type: Class
subclass of: SO_0000704
imported from: mondo.owl

HAAO
type: Class
subclass of: SO_0000704
imported from: mondo.owl

HBB
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CFH
type: Class
subclass of: SO_0000704
imported from: mondo.owl

HNF4A
type: Class
subclass of: SO_0000704
imported from: mondo.owl

HPRT1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

HSD11B2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CFI
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ABCC6
type: Class
subclass of: SO_0000704
imported from: mondo.owl

APOE
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ITGA3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

JAG1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

KCNJ1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

KCNJ10
type: Class
subclass of: SO_0000704
imported from: mondo.owl

APRT
type: Class
subclass of: SO_0000704
imported from: mondo.owl

KCNK3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

AQP2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

KLHL3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

KRAS
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MAFB
type: Class
subclass of: SO_0000704
imported from: mondo.owl

KYNU
type: Class
subclass of: SO_0000704
imported from: mondo.owl

LAMB2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

LBR
type: Class
subclass of: SO_0000704
imported from: mondo.owl

LCAT
type: Class
subclass of: SO_0000704
imported from: mondo.owl

LMX1B
type: Class
subclass of: SO_0000704
imported from: mondo.owl

LZTFL1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

LZTR1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MAD2L2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SMAD9
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ARHGDIA
type: Class
subclass of: SO_0000704
imported from: mondo.owl

CD46
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MEFV
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MKKS
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MKS1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MME
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MTR
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MUC1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MMUT
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MYH9
type: Class
subclass of: SO_0000704
imported from: mondo.owl

MYO1E
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NEK1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NEU1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NF1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NODAL
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NOTCH2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NPHP1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NPHP3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NPHS1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NR3C2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

NRAS
type: Class
subclass of: SO_0000704
imported from: mondo.owl

OCRL
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ATP6V1B1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PAX2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PAX4
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ATP6V0A4
type: Class
subclass of: SO_0000704
imported from: mondo.owl

ATP7B
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PDE3A
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX10
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX12
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX13
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX14
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX16
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX3
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX6
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX7
type: Class
subclass of: SO_0000704
imported from: mondo.owl

AVP
type: Class
subclass of: SO_0000704
imported from: mondo.owl

SERPINA1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PIGA
type: Class
subclass of: SO_0000704
imported from: mondo.owl

AVPR2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PKD1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PKD2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PKHD1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PRPS1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PTEN
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PTPN11
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BBS1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BBS2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PTPRO
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BBS4
type: Class
subclass of: SO_0000704
imported from: mondo.owl

BBS5
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX19
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX2
type: Class
subclass of: SO_0000704
imported from: mondo.owl

PEX5
type: Class
subclass of: SO_0000704
imported from: mondo.owl

RAD51
type: Class
subclass of: SO_0000704
imported from: mondo.owl

RAD51C
type: Class
subclass of: SO_0000704
imported from: mondo.owl

RAF1
type: Class
subclass of: SO_0000704
imported from: mondo.owl

REN
type: Class
subclass of: SO_0000704
imported from: mondo.owl

REST
type: Class
subclass of: SO_0000704
imported from: mondo.owl

entity
type: Class
subclass of: Thing
subclass of: Restriction
  on property: exists at
  some values from: temporal region
BFO OWL specification label: entity
BFO CLIF specification label: Entity
editor preferred label: entity
example of usage: Julius Caesar
example of usage: Verdi’s Requiem
example of usage: the Second World War
example of usage: your body mass index
editor note: BFO 2 Reference: In all areas of empirical inquiry we encounter general terms of two sorts. First are general terms which refer to universals or types:animaltuberculosissurgical procedurediseaseSecond, are general terms used to refer to groups of entities which instantiate a given universal but do not correspond to the extension of any subuniversal of that universal because there is nothing intrinsic to the entities in question by virtue of which they – and only they – are counted as belonging to the given group. Examples are: animal purchased by the Emperortuberculosis diagnosed on a Wednesdaysurgical procedure performed on a patient from Stockholmperson identified as candidate for clinical trial #2056-555person who is signatory of Form 656-PPVpainting by Leonardo da VinciSuch terms, which represent what are called ‘specializations’ in [81
editor note: Entity doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example Werner Ceusters 'portions of reality' include 4 sorts, entities (as BFO construes them), universals, configurations, and relations. It is an open question as to whether entities as construed in BFO will at some point also include these other portions of reality. See, for example, 'How to track absolutely everything' at http://www.referent-tracking.com/_RTU/papers/CeustersICbookRevised.pdf
imported from: BFO
imported from: bfo.owl
imported from: dron.owl
imported from: envo.owl
imported from: iao.owl
imported from: ico.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: vo.owl
elucidation: An entity is anything that exists or has existed or will exist. (axiom label in BFO2 Reference: [001-001])

continuant
type: Class
subclass of: entity
subclass of: Restriction
  on property: part of
  all values from: continuant
BFO OWL specification label: continuant
BFO CLIF specification label: Continuant
editor preferred label: continuant
textual definition: An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.
editor note: BFO 2 Reference: Continuant entities are entities which can be sliced to yield parts only along the spatial dimension, yielding for example the parts of your table which we call its legs, its top, its nails. ‘My desk stretches from the window to the door. It has spatial parts, and can be sliced (in space) in two. With respect to time, however, a thing is a continuant.’ [60, p. 240
editor note: Continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. For example, in an expansion involving bringing in some of Ceuster's other portions of reality, questions are raised as to whether universals are continuants
imported from: BFO
imported from: bfo.owl
imported from: cl.owl
imported from: dron.owl
imported from: envo.owl
imported from: hp.owl
imported from: iao.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: pato.owl
imported from: po.owl
imported from: ro.owl
imported from: vo.owl
elucidation: A continuant is an entity that persists, endures, or continues to exist through time while maintaining its identity. (axiom label in BFO2 Reference: [008-002])
has associated axiom(nl): if b is a continuant and if, for some t, c has_continuant_part b at t, then c is a continuant. (axiom label in BFO2 Reference: [126-001])
has associated axiom(nl): if b is a continuant and if, for some t, cis continuant_part of b at t, then c is a continuant. (axiom label in BFO2 Reference: [009-002])
has associated axiom(nl): if b is a material entity, then there is some temporal interval (referred to below as a one-dimensional temporal region) during which b exists. (axiom label in BFO2 Reference: [011-002])
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (continuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [009-002]
has associated axiom(fol): (forall (x y) (if (and (Continuant x) (exists (t) (hasContinuantPartOfAt y x t))) (Continuant y))) // axiom label in BFO2 CLIF: [126-001]
has associated axiom(fol): (forall (x) (if (Continuant x) (Entity x))) // axiom label in BFO2 CLIF: [008-002]
has associated axiom(fol): (forall (x) (if (Material Entity x) (exists (t) (and (TemporalRegion t) (existsAt x t))))) // axiom label in BFO2 CLIF: [011-002]

occurrent
type: Class
subclass of: entity
subclass of: Restriction
  on property: part of
  all values from: occurrent
BFO OWL specification label: occurrent
BFO CLIF specification label: Occurrent
editor preferred label: occurrent
textual definition: An entity that has temporal parts and that happens, unfolds or develops through time.
editor note: BFO 2 Reference: every occurrent that is not a temporal or spatiotemporal region is s-dependent on some independent continuant that is not a spatial region
editor note: BFO 2 Reference: s-dependence obtains between every process and its participants in the sense that, as a matter of necessity, this process could not have existed unless these or those participants existed also. A process may have a succession of participants at different phases of its unfolding. Thus there may be different players on the field at different times during the course of a football game; but the process which is the entire game s-depends_on all of these players nonetheless. Some temporal parts of this process will s-depend_on on only some of the players.
editor note: Occurrent doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. An example would be the sum of a process and the process boundary of another process.
editor note: Simons uses different terminology for relations of occurrents to regions: Denote the spatio-temporal location of a given occurrent e by 'spn[e]' and call this region its span. We may say an occurrent is at its span, in any larger region, and covers any smaller region. Now suppose we have fixed a frame of reference so that we can speak not merely of spatio-temporal but also of spatial regions (places) and temporal regions (times). The spread of an occurrent, (relative to a frame of reference) is the space it exactly occupies, and its spell is likewise the time it exactly occupies. We write 'spr[e]' and `spl[e]' respectively for the spread and spell of e, omitting mention of the frame.
imported from: BFO
imported from: bfo.owl
imported from: cl.owl
imported from: dron.owl
imported from: envo.owl
imported from: hp.owl
imported from: iao.owl
imported from: ico.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: po.owl
imported from: ro.owl
imported from: vo.owl
elucidation: An occurrent is an entity that unfolds itself in time or it is the instantaneous boundary of such an entity (for example a beginning or an ending) or it is a temporal or spatiotemporal region which such an entity occupies_temporal_region or occupies_spatiotemporal_region. (axiom label in BFO2 Reference: [077-002])
has associated axiom(nl): Every occurrent occupies_spatiotemporal_region some spatiotemporal region. (axiom label in BFO2 Reference: [108-001])
has associated axiom(nl): b is an occurrent entity iff b is an entity that has temporal parts. (axiom label in BFO2 Reference: [079-001])
has associated axiom(fol): (forall (x) (if (Occurrent x) (exists (r) (and (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion x r))))) // axiom label in BFO2 CLIF: [108-001]
has associated axiom(fol): (forall (x) (iff (Occurrent x) (and (Entity x) (exists (y) (temporalPartOf y x))))) // axiom label in BFO2 CLIF: [079-001]

independent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: occupies spatial region at some time
  some values from: spatial region
subclass of: Restriction
  on property: part of
  all values from: independent continuant
subclass of: Restriction
  on property: specifically depends on at some time
  all values from: Nothing
subclass of: Restriction
  on property: part of continuant at some time
  all values from: Class
    complement of: Class
      union of: specifically dependent continuant
      union of: generically dependent continuant
subclass of: Restriction
  on property: part of continuant at all times that whole exists
  all values from: Class
    complement of: Class
      union of: specifically dependent continuant
      union of: generically dependent continuant
BFO OWL specification label: ic
BFO CLIF specification label: IndependentContinuant
example of usage: a chair
example of usage: a heart
example of usage: a leg
example of usage: a molecule
example of usage: a spatial region
example of usage: an atom
example of usage: an orchestra.
example of usage: an organism
example of usage: the bottom right portion of a human torso
example of usage: the interior of your mouth
textual definition: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
textual definition: b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
imported from: BFO
imported from: bfo.owl
imported from: cl.owl
imported from: dron.owl
imported from: envo.owl
imported from: hp.owl
imported from: iao.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
imported from: omrse.owl
imported from: po.owl
imported from: ro.owl
imported from: vo.owl
has associated axiom(nl): For any independent continuant b and any time t there is some spatial region r such that b is located_in r at t. (axiom label in BFO2 Reference: [134-001])
has associated axiom(nl): For every independent continuant b and time t during the region of time spanned by its life, there are entities which s-depends_on b during t. (axiom label in BFO2 Reference: [018-002])
has associated axiom(fol): (forall (x t) (if (IndependentContinuant x) (exists (r) (and (SpatialRegion r) (locatedInAt x r t))))) // axiom label in BFO2 CLIF: [134-001]
has associated axiom(fol): (forall (x t) (if (and (IndependentContinuant x) (existsAt x t)) (exists (y) (and (Entity y) (specificallyDependsOnAt y x t))))) // axiom label in BFO2 CLIF: [018-002]
has associated axiom(fol): (iff (IndependentContinuant a) (and (Continuant a) (not (exists (b t) (specificallyDependsOnAt a b t))))) // axiom label in BFO2 CLIF: [017-002]
comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.

spatial region
type: Class
subclass of: immaterial entity
subclass of: Restriction
  on property: part of continuant at some time
  all values from: spatial region
subclass of: Restriction
  on property: has continuant part at some time
  all values from: spatial region
subclass of: Restriction
  on property: part of continuant at all times that whole exists
  all values from: spatial region
subclass of: Restriction
  on property: has continuant part at all times that part exists
  all values from: spatial region
subclass of: Restriction
  on property: occupies spatial region at some time
  has self: true
subclass of: Restriction
  on property: has spatial occupant at some time
  has self: true
BFO OWL specification label: s-region
BFO CLIF specification label: SpatialRegion
editor note: BFO 2 Reference: Spatial regions do not participate in processes.
editor note: Spatial region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the union of a spatial point and a spatial line that doesn't overlap the point, or two spatial lines that intersect at a single point. In both cases the resultant spatial region is neither 0-dimensional, 1-dimensional, 2-dimensional, or 3-dimensional.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: obi.owl
imported from: ogg.owl
imported from: vo.owl
elucidation: A spatial region is a continuant entity that is a continuant_part_of spaceR as defined relative to some frame R. (axiom label in BFO2 Reference: [035-001])
has associated axiom(nl): All continuant parts of spatial regions are spatial regions. (axiom label in BFO2 Reference: [036-001])
has associated axiom(fol): (forall (x y t) (if (and (SpatialRegion x) (continuantPartOfAt y x t)) (SpatialRegion y))) // axiom label in BFO2 CLIF: [036-001]
has associated axiom(fol): (forall (x) (if (SpatialRegion x) (Continuant x))) // axiom label in BFO2 CLIF: [035-001]

temporal region
type: Class
subclass of: occurrent
subclass of: Restriction
  on property: has occurrent part
  all values from: temporal region
subclass of: Restriction
  on property: part of occurrent
  all values from: temporal region
subclass of: Restriction
  on property: occupies temporal region
  has self: true
subclass of: Restriction
  on property: has temporal occupant
  has self: true
BFO OWL specification label: t-region
BFO CLIF specification label: TemporalRegion
editor note: Temporal region doesn't have a closure axiom because the subclasses don't exhaust all possibilites. An example would be the mereological sum of a temporal instant and a temporal interval that doesn't overlap the instant. In this case the resultant temporal region is neither 0-dimensional nor 1-dimensional
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
elucidation: A temporal region is an occurrent entity that is part of time as defined relative to some reference frame. (axiom label in BFO2 Reference: [100-001])
has associated axiom(nl): All parts of temporal regions are temporal regions. (axiom label in BFO2 Reference: [101-001])
has associated axiom(nl): Every temporal region t is such that t occupies_temporal_region t. (axiom label in BFO2 Reference: [119-002])
has associated axiom(fol): (forall (r) (if (TemporalRegion r) (occupiesTemporalRegion r r))) // axiom label in BFO2 CLIF: [119-002]
has associated axiom(fol): (forall (x y) (if (and (TemporalRegion x) (occurrentPartOf y x)) (TemporalRegion y))) // axiom label in BFO2 CLIF: [101-001]
has associated axiom(fol): (forall (x) (if (TemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [100-001]

spatiotemporal region
type: Class
subclass of: occurrent
subclass of: Restriction
  on property: projects onto spatial region at some time
  some values from: spatial region
subclass of: Restriction
  on property: projects onto temporal region
  some values from: temporal region
subclass of: Restriction
  on property: has occurrent part
  all values from: spatiotemporal region
subclass of: Restriction
  on property: part of occurrent
  all values from: spatiotemporal region
subclass of: Restriction
  on property: has spatiotemporal occupant
  has self: true
subclass of: Restriction
  on property: occupies spatiotemporal region
  has self: true
BFO OWL specification label: st-region
BFO CLIF specification label: SpatiotemporalRegion
example of usage: the spatiotemporal region occupied by a human life
example of usage: the spatiotemporal region occupied by a process of cellular meiosis.
example of usage: the spatiotemporal region occupied by the development of a cancer tumor
imported from: ogg.owl
elucidation: A spatiotemporal region is an occurrent entity that is part of spacetime. (axiom label in BFO2 Reference: [095-001])
has associated axiom(nl): All parts of spatiotemporal regions are spatiotemporal regions. (axiom label in BFO2 Reference: [096-001])
has associated axiom(nl): Each spatiotemporal region at any time t projects_onto some spatial region at t. (axiom label in BFO2 Reference: [099-001])
has associated axiom(nl): Each spatiotemporal region projects_onto some temporal region. (axiom label in BFO2 Reference: [098-001])
has associated axiom(nl): Every spatiotemporal region occupies_spatiotemporal_region itself.
has associated axiom(nl): Every spatiotemporal region s is such that s occupies_spatiotemporal_region s. (axiom label in BFO2 Reference: [107-002])
has associated axiom(fol): (forall (r) (if (SpatioTemporalRegion r) (occupiesSpatioTemporalRegion r r))) // axiom label in BFO2 CLIF: [107-002]
has associated axiom(fol): (forall (x t) (if (SpatioTemporalRegion x) (exists (y) (and (SpatialRegion y) (spatiallyProjectsOntoAt x y t))))) // axiom label in BFO2 CLIF: [099-001]
has associated axiom(fol): (forall (x y) (if (and (SpatioTemporalRegion x) (occurrentPartOf y x)) (SpatioTemporalRegion y))) // axiom label in BFO2 CLIF: [096-001]
has associated axiom(fol): (forall (x) (if (SpatioTemporalRegion x) (Occurrent x))) // axiom label in BFO2 CLIF: [095-001]
has associated axiom(fol): (forall (x) (if (SpatioTemporalRegion x) (exists (y) (and (TemporalRegion y) (temporallyProjectsOnto x y))))) // axiom label in BFO2 CLIF: [098-001]

process
type: Class
subclass of: occurrent
subclass of: Restriction
  on property: specifically depends on at some time
  some values from: material entity
subclass of: Restriction
  on property: has occurrent part
  all values from: Class
    union of: process
    union of: process boundary
subclass of: Restriction
  on property: part of occurrent
  all values from: process
BFO OWL specification label: process
BFO CLIF specification label: Process
editor preferred label: process
example of usage: a process of cell-division, \ a beating of the heart
example of usage: a process of meiosis
example of usage: a process of sleeping
example of usage: the course of a disease
example of usage: the flight of a bird
example of usage: the life of an organism
example of usage: your process of aging.
textual definition: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
textual definition: p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
editor note: BFO 2 Reference: The realm of occurrents is less pervasively marked by the presence of natural units than is the case in the realm of independent continuants. Thus there is here no counterpart of ‘object’. In BFO 1.0 ‘process’ served as such a counterpart. In BFO 2.0 ‘process’ is, rather, the occurrent counterpart of ‘material entity’. Those natural – as contrasted with engineered, which here means: deliberately executed – units which do exist in the realm of occurrents are typically either parasitic on the existence of natural units on the continuant side, or they are fiat in nature. Thus we can count lives; we can count football games; we can count chemical reactions performed in experiments or in chemical manufacturing. We cannot count the processes taking place, for instance, in an episode of insect mating behavior.Even where natural units are identifiable, for example cycles in a cyclical process such as the beating of a heart or an organism’s sleep/wake cycle, the processes in question form a sequence with no discontinuities (temporal gaps) of the sort that we find for instance where billiard balls or zebrafish or planets are separated by clear spatial gaps. Lives of organisms are process units, but they too unfold in a continuous series from other, prior processes such as fertilization, and they unfold in turn in continuous series of post-life processes such as post-mortem decay. Clear examples of boundaries of processes are almost always of the fiat sort (midnight, a time of death as declared in an operating theater or on a death certificate, the initiation of a state of war)
imported from: BFO
imported from: bfo.owl
imported from: cl.owl
imported from: dron.owl
imported from: envo.owl
imported from: hp.owl
imported from: iao.owl
imported from: ico.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: ro.owl
imported from: vo.owl
has associated axiom(fol): (iff (Process a) (and (Occurrent a) (exists (b) (properTemporalPartOf b a)) (exists (c t) (and (MaterialEntity c) (specificallyDependsOnAt a c t))))) // axiom label in BFO2 CLIF: [083-003]
comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.

disposition
type: Class
subclass of: realizable entity
subclass of: Restriction
  on property: part of continuant at some time
  all values from: Class
    complement of: role
subclass of: Restriction
  on property: part of continuant at all times that whole exists
  all values from: Class
    complement of: role
BFO OWL specification label: disposition
BFO CLIF specification label: Disposition
example of usage: an atom of element X has the disposition to decay to an atom of element Y
example of usage: certain people have a predisposition to colon cancer
example of usage: children are innately disposed to categorize objects in certain ways.
example of usage: the cell wall is disposed to filter chemicals in endocitosis and exocitosis
example of usage: the cell wall is disposed to filter chemicals in endocytosis and exocytosis
editor note: BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type [89
editor note: BFO 2 Reference: Dispositions exist along a strength continuum. Weaker forms of disposition are realized in only a fraction of triggering cases. These forms occur in a significant number of cases of a similar type.
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: ogg.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: vo.owl
elucidation: b is a disposition means: b is a realizable entity & b’s bearer is some material entity & b is such that if it ceases to exist, then its bearer is physically changed, & b’s realization occurs when and because this bearer is in some special physical circumstances, & this realization occurs in virtue of the bearer’s physical make-up. (axiom label in BFO2 Reference: [062-002])
has associated axiom(nl): If b is a realizable entity then for all t at which b exists, b s-depends_on some material entity at t. (axiom label in BFO2 Reference: [063-002])
has associated axiom(fol): (forall (x t) (if (and (RealizableEntity x) (existsAt x t)) (exists (y) (and (MaterialEntity y) (specificallyDepends x y t))))) // axiom label in BFO2 CLIF: [063-002]
has associated axiom(fol): (forall (x) (if (Disposition x) (and (RealizableEntity x) (exists (y) (and (MaterialEntity y) (bearerOfAt x y t)))))) // axiom label in BFO2 CLIF: [062-002]

realizable entity
type: Class
subclass of: specifically dependent continuant
subclass of: Restriction
  on property: part of
  all values from: realizable entity
subclass of: Restriction
  on property: part of continuant at some time
  all values from: Class
    complement of: quality
subclass of: Restriction
  on property: part of continuant at all times that whole exists
  all values from: Class
    complement of: quality
BFO OWL specification label: realizable
BFO CLIF specification label: RealizableEntity
example of usage: the disposition of this piece of metal to conduct electricity.
example of usage: the disposition of your blood to coagulate
example of usage: the function of your reproductive organs
example of usage: the role of being a doctor
example of usage: the role of this boundary to delineate where Utah and Colorado meet
textual definition: A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.
imported from: cl.owl
imported from: dron.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: vo.owl
elucidation: To say that b is a realizable entity is to say that b is a specifically dependent continuant that inheres in some independent continuant which is not a spatial region and is of a type instances of which are realized in processes of a correlated type. (axiom label in BFO2 Reference: [058-002])
has associated axiom(nl): All realizable dependent continuants have independent continuants that are not spatial regions as their bearers. (axiom label in BFO2 Reference: [060-002])
has associated axiom(fol): (forall (x t) (if (RealizableEntity x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (bearerOfAt y x t))))) // axiom label in BFO2 CLIF: [060-002]
has associated axiom(fol): (forall (x) (if (RealizableEntity x) (and (SpecificallyDependentContinuant x) (exists (y) (and (IndependentContinuant y) (not (SpatialRegion y)) (inheresIn x y)))))) // axiom label in BFO2 CLIF: [058-002]

quality
type: Class
subclass of: specifically dependent continuant
subclass of: Restriction
  on property: part of
  all values from: quality
subclass of: Restriction
  on property: part of continuant at some time
  all values from: Class
    complement of: realizable entity
subclass of: Restriction
  on property: part of continuant at all times that whole exists
  all values from: Class
    complement of: realizable entity
BFO OWL specification label: quality
BFO CLIF specification label: Quality
editor preferred label: quality
example of usage: the ambient temperature of this portion of air
example of usage: the color of a tomato
example of usage: the length of the circumference of your waist
example of usage: the mass of this piece of gold.
example of usage: the shape of your nose
example of usage: the shape of your nostril
imported from: bfo.owl
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: ogg.owl
imported from: pato.owl
imported from: pr.owl
imported from: ro.owl
elucidation: a quality is a specifically dependent continuant that, in contrast to roles and dispositions, does not require any further process in order to be realized. (axiom label in BFO2 Reference: [055-001])
has associated axiom(nl): If an entity is a quality at any time that it exists, then it is a quality at every time that it exists. (axiom label in BFO2 Reference: [105-001])
has associated axiom(fol): (forall (x) (if (Quality x) (SpecificallyDependentContinuant x))) // axiom label in BFO2 CLIF: [055-001]
has associated axiom(fol): (forall (x) (if (exists (t) (and (existsAt x t) (Quality x))) (forall (t_1) (if (existsAt x t_1) (Quality x))))) // axiom label in BFO2 CLIF: [105-001]
has_obo_namespace: bfo
id: BFO:0000019

specifically dependent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: inheres in at all times
  some values from: Class
    intersection of: independent continuant
    intersection of: Class
      complement of: spatial region
subclass of: Restriction
  on property: part of
  all values from: specifically dependent continuant
subclass of: Restriction
  on property: part of continuant at some time
  all values from: Class
    complement of: Class
      union of: independent continuant
      union of: generically dependent continuant
subclass of: Restriction
  on property: part of continuant at all times that whole exists
  all values from: Class
    complement of: Class
      union of: independent continuant
      union of: generically dependent continuant
BFO OWL specification label: sdc
BFO CLIF specification label: SpecificallyDependentContinuant
editor preferred label: specifically dependent continuant
example of usage: Reciprocal specifically dependent continuants: the function of this key to open this lock and the mutually dependent disposition of this lock: to be opened by this key
example of usage: of one-sided specifically dependent continuants: the mass of this tomato
example of usage: of relational dependent continuants (multiple bearers): John’s love for Mary, the ownership relation between John and this statue, the relation of authority between John and his subordinates.
example of usage: the disposition of this fish to decay
example of usage: the function of this heart: to pump blood
example of usage: the mutual dependence of proton donors and acceptors in chemical reactions [79
example of usage: the mutual dependence of the role predator and the role prey as played by two organisms in a given interaction
example of usage: the pink color of a medium rare piece of grilled filet mignon at its center
example of usage: the role of being a doctor
example of usage: the shape of this hole.
example of usage: the smell of this portion of mozzarella
textual definition: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
textual definition: b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004])
textual definition: b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
editor note: Specifically dependent continuant doesn't have a closure axiom because the subclasses don't necessarily exhaust all possibilites. We're not sure what else will develop here, but for example there are questions such as what are promises, obligation, etc.
imported from: bfo.owl
imported from: cl.owl
imported from: dron.owl
imported from: envo.owl
imported from: hp.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: pato.owl
imported from: ro.owl
imported from: vo.owl
has associated axiom(fol): (iff (RelationalSpecificallyDependentContinuant a) (and (SpecificallyDependentContinuant a) (forall (t) (exists (b c) (and (not (SpatialRegion b)) (not (SpatialRegion c)) (not (= b c)) (not (exists (d) (and (continuantPartOfAt d b t) (continuantPartOfAt d c t)))) (specificallyDependsOnAt a b t) (specificallyDependsOnAt a c t)))))) // axiom label in BFO2 CLIF: [131-004]
has associated axiom(fol): (iff (SpecificallyDependentContinuant a) (and (Continuant a) (forall (t) (if (existsAt a t) (exists (b) (and (IndependentContinuant b) (not (SpatialRegion b)) (specificallyDependsOnAt a b t))))))) // axiom label in BFO2 CLIF: [050-003]
comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.

role
type: Class
subclass of: realizable entity
subclass of: Restriction
  on property: part of continuant at some time
  all values from: Class
    complement of: disposition
subclass of: Restriction
  on property: part of continuant at all times that whole exists
  all values from: Class
    complement of: disposition
BFO OWL specification label: role
BFO CLIF specification label: Role
example of usage: John’s role of husband to Mary is dependent on Mary’s role of wife to John, and both are dependent on the object aggregate comprising John and Mary as member parts joined together through the relational quality of being married.
example of usage: the priest role
example of usage: the role of a boundary to demarcate two neighboring administrative territories
example of usage: the role of a building in serving as a military target
example of usage: the role of a stone in marking a property boundary
example of usage: the role of subject in a clinical trial
example of usage: the student role
textual definition: A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts.
editor note: BFO 2 Reference: One major family of examples of non-rigid universals involves roles, and ontologies developed for corresponding administrative purposes may consist entirely of representatives of entities of this sort. Thus ‘professor’, defined as follows,b instance_of professor at t =Def. there is some c, c instance_of professor role & c inheres_in b at t.denotes a non-rigid universal and so also do ‘nurse’, ‘student’, ‘colonel’, ‘taxpayer’, and so forth. (These terms are all, in the jargon of philosophy, phase sortals.) By using role terms in definitions, we can create a BFO conformant treatment of such entities drawing on the fact that, while an instance of professor may be simultaneously an instance of trade union member, no instance of the type professor role is also (at any time) an instance of the type trade union member role (any more than any instance of the type color is at any time an instance of the type length).If an ontology of employment positions should be defined in terms of roles following the above pattern, this enables the ontology to do justice to the fact that individuals instantiate the corresponding universals – professor, sergeant, nurse – only during certain phases in their lives.
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
imported from: omrse.owl
imported from: vo.owl
elucidation: b is a role means: b is a realizable entity & b exists because there is some single bearer that is in some special physical, social, or institutional set of circumstances in which this bearer does not have to be& b is not such that, if it ceases to exist, then the physical make-up of the bearer is thereby changed. (axiom label in BFO2 Reference: [061-001])
has associated axiom(fol): (forall (x) (if (Role x) (RealizableEntity x))) // axiom label in BFO2 CLIF: [061-001]

fiat object
type: Class
subclass of: material entity
BFO OWL specification label: fiat-object-part
BFO CLIF specification label: FiatObjectPart
example of usage: or with divisions drawn by cognitive subjects for practical reasons, such as the division of a cake (before slicing) into (what will become) slices (and thus member parts of an object aggregate). However, this does not mean that fiat object parts are dependent for their existence on divisions or delineations effected by cognitive subjects. If, for example, it is correct to conceive geological layers of the Earth as fiat object parts of the Earth, then even though these layers were first delineated in recent times, still existed long before such delineation and what holds of these layers (for example that the oldest layers are also the lowest layers) did not begin to hold because of our acts of delineation.Treatment of material entity in BFOExamples viewed by some as problematic cases for the trichotomy of fiat object part, object, and object aggregate include: a mussel on (and attached to) a rock, a slime mold, a pizza, a cloud, a galaxy, a railway train with engine and multiple carriages, a clonal stand of quaking aspen, a bacterial community (biofilm), a broken femur. Note that, as Aristotle already clearly recognized, such problematic cases – which lie at or near the penumbra of instances defined by the categories in question – need not invalidate these categories. The existence of grey objects does not prove that there are not objects which are black and objects which are white; the existence of mules does not prove that there are not objects which are donkeys and objects which are horses. It does, however, show that the examples in question need to be addressed carefully in order to show how they can be fitted into the proposed scheme, for example by recognizing additional subdivisions [29
example of usage: the FMA:regional parts of an intact human body.
example of usage: the Western hemisphere of the Earth
example of usage: the division of the brain into regions
example of usage: the division of the planet into hemispheres
example of usage: the dorsal and ventral surfaces of the body
example of usage: the upper and lower lobes of the left lung
editor note: BFO 2 Reference: Most examples of fiat object parts are associated with theoretically drawn divisions
imported from: envo.owl
imported from: mondo.owl
elucidation: b is a fiat object part = Def. b is a material entity which is such that for all times t, if b exists at t then there is some object c such that b proper continuant_part of c at t and c is demarcated from the remainder of c by a two-dimensional continuant fiat boundary. (axiom label in BFO2 Reference: [027-004])
has associated axiom(fol): (forall (x) (if (FiatObjectPart x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y) (and (Object y) (properContinuantPartOfAt x y t)))))))) // axiom label in BFO2 CLIF: [027-004]
label: fiat object part

object aggregate
type: Class
subclass of: material entity
BFO OWL specification label: object-aggregate
BFO CLIF specification label: ObjectAggregate
example of usage: a collection of cells in a blood biobank.
example of usage: a swarm of bees is an aggregate of members who are linked together through natural bonds
example of usage: a symphony orchestra
example of usage: an organization is an aggregate whose member parts have roles of specific types (for example in a jazz band, a chess club, a football team)
example of usage: defined by fiat: the aggregate of members of an organization
example of usage: defined through physical attachment: the aggregate of atoms in a lump of granite
example of usage: defined through physical containment: the aggregate of molecules of carbon dioxide in a sealed container
example of usage: defined via attributive delimitations such as: the patients in this hospital
example of usage: the aggregate of bearings in a constant velocity axle joint
example of usage: the aggregate of blood cells in your body
example of usage: the nitrogen atoms in the atmosphere
example of usage: the restaurants in Palo Alto
example of usage: your collection of Meissen ceramic plates.
editor note: An entity a is an object aggregate if and only if there is a mutually exhaustive and pairwise disjoint partition of a into objects
editor note: BFO 2 Reference: object aggregates may gain and lose parts while remaining numerically identical (one and the same individual) over time. This holds both for aggregates whose membership is determined naturally (the aggregate of cells in your body) and aggregates determined by fiat (a baseball team, a congressional committee).
definition source: ISBN:978-3-938793-98-5pp124-158#Thomas Bittner and Barry Smith, 'A Theory of Granular Partitions', in K. Munn and B. Smith (eds.), Applied Ontology: An Introduction, Frankfurt/Lancaster: ontos, 2008, 125-158.
imported from: dron.owl
imported from: envo.owl
elucidation: b is an object aggregate means: b is a material entity consisting exactly of a plurality of objects as member_parts at all times at which b exists. (axiom label in BFO2 Reference: [025-004])
has associated axiom(fol): (forall (x) (if (ObjectAggregate x) (and (MaterialEntity x) (forall (t) (if (existsAt x t) (exists (y z) (and (Object y) (Object z) (memberPartOfAt y x t) (memberPartOfAt z x t) (not (= y z)))))) (not (exists (w t_1) (and (memberPartOfAt w x t_1) (not (Object w)))))))) // axiom label in BFO2 CLIF: [025-004]

three-dimensional spatial region
type: Class
subclass of: spatial region
BFO OWL specification label: 3d-s-region
BFO CLIF specification label: ThreeDimensionalSpatialRegion
example of usage: a cube-shaped region of space
example of usage: a sphere-shaped region of space,
imported from: ogg.owl
elucidation: A three-dimensional spatial region is a spatial region that is of three dimensions. (axiom label in BFO2 Reference: [040-001])
has associated axiom(fol): (forall (x) (if (ThreeDimensionalSpatialRegion x) (SpatialRegion x))) // axiom label in BFO2 CLIF: [040-001]

site
type: Class
subclass of: immaterial entity
BFO OWL specification label: site
BFO CLIF specification label: Site
example of usage: Manhattan Canyon)
example of usage: a hole in the interior of a portion of cheese
example of usage: a rabbit hole
example of usage: an air traffic control region defined in the airspace above an airport
example of usage: the Grand Canyon
example of usage: the Piazza San Marco
example of usage: the cockpit of an aircraft
example of usage: the hold of a ship
example of usage: the interior of a kangaroo pouch
example of usage: the interior of the trunk of your car
example of usage: the interior of your bedroom
example of usage: the interior of your office
example of usage: the interior of your refrigerator
example of usage: the lumen of your gut
example of usage: your left nostril (a fiat part – the opening – of your left nasal cavity)
imported from: envo.owl
imported from: iao.owl
imported from: obi.owl
imported from: omrse.owl
imported from: vo.owl
elucidation: b is a site means: b is a three-dimensional immaterial entity that is (partially or wholly) bounded by a material entity or it is a three-dimensional immaterial part thereof. (axiom label in BFO2 Reference: [034-002])
has associated axiom(fol): (forall (x) (if (Site x) (ImmaterialEntity x))) // axiom label in BFO2 CLIF: [034-002]

object
type: Class
subclass of: material entity
BFO OWL specification label: object
BFO CLIF specification label: Object
example of usage: atom
example of usage: cell
example of usage: cells and organisms
example of usage: engineered artifacts
example of usage: grain of sand
example of usage: molecule
example of usage: organelle
example of usage: organism
example of usage: planet
example of usage: solid portions of matter
example of usage: star
editor note: BFO 2 Reference: BFO rests on the presupposition that at multiple micro-, meso- and macroscopic scales reality exhibits certain stable, spatially separated or separable material units, combined or combinable into aggregates of various sorts (for example organisms into what are called ‘populations’). Such units play a central role in almost all domains of natural science from particle physics to cosmology. Many scientific laws govern the units in question, employing general terms (such as ‘molecule’ or ‘planet’) referring to the types and subtypes of units, and also to the types and subtypes of the processes through which such units develop and interact. The division of reality into such natural units is at the heart of biological science, as also is the fact that these units may form higher-level units (as cells form multicellular organisms) and that they may also form aggregates of units, for example as cells form portions of tissue and organs form families, herds, breeds, species, and so on. At the same time, the division of certain portions of reality into engineered units (manufactured artifacts) is the basis of modern industrial technology, which rests on the distributed mass production of engineered parts through division of labor and on their assembly into larger, compound units such as cars and laptops. The division of portions of reality into units is one starting point for the phenomenon of counting.
editor note: BFO 2 Reference: Each object is such that there are entities of which we can assert unproblematically that they lie in its interior, and other entities of which we can assert unproblematically that they lie in its exterior. This may not be so for entities lying at or near the boundary between the interior and exterior. This means that two objects – for example the two cells depicted in Figure 3 – may be such that there are material entities crossing their boundaries which belong determinately to neither cell. Something similar obtains in certain cases of conjoined twins (see below).
editor note: BFO 2 Reference: To say that b is causally unified means: b is a material entity which is such that its material parts are tied together in such a way that, in environments typical for entities of the type in question,if c, a continuant part of b that is in the interior of b at t, is larger than a certain threshold size (which will be determined differently from case to case, depending on factors such as porosity of external cover) and is moved in space to be at t at a location on the exterior of the spatial region that had been occupied by b at t, then either b’s other parts will be moved in coordinated fashion or b will be damaged (be affected, for example, by breakage or tearing) in the interval between t and t.causal changes in one part of b can have consequences for other parts of b without the mediation of any entity that lies on the exterior of b. Material entities with no proper material parts would satisfy these conditions trivially. Candidate examples of types of causal unity for material entities of more complex sorts are as follows (this is not intended to be an exhaustive list):CU1: Causal unity via physical coveringHere the parts in the interior of the unified entity are combined together causally through a common membrane or other physical covering\. The latter points outwards toward and may serve a protective function in relation to what lies on the exterior of the entity [13, 47
editor note: BFO 2 Reference: an object is a maximal causally unified material entity
editor note: BFO 2 Reference: ‘objects’ are sometimes referred to as ‘grains’ [74
imported from: dron.owl
imported from: envo.owl
imported from: mondo.owl
imported from: pr.owl
elucidation: b is an object means: b is a material entity which manifests causal unity of one or other of the types CUn listed above & is of a type (a material universal) instances of which are maximal relative to this criterion of causal unity. (axiom label in BFO2 Reference: [024-001])
has_obo_namespace: bfo
id: BFO:0000030

generically dependent continuant
type: Class
subclass of: continuant
subclass of: Restriction
  on property: concretized by at some time
  some values from: specifically dependent continuant
subclass of: Restriction
  on property: part of
  all values from: generically dependent continuant
subclass of: Restriction
  on property: part of continuant at some time
  all values from: Class
    complement of: Class
      union of: independent continuant
      union of: specifically dependent continuant
subclass of: Restriction
  on property: part of continuant at all times that whole exists
  all values from: Class
    complement of: Class
      union of: independent continuant
      union of: specifically dependent continuant
BFO OWL specification label: gdc
BFO CLIF specification label: GenericallyDependentContinuant
example of usage: The entries in your database are patterns instantiated as quality instances in your hard drive. The database itself is an aggregate of such patterns. When you create the database you create a particular instance of the generically dependent continuant type database. Each entry in the database is an instance of the generically dependent continuant type IAO: information content entity.
example of usage: the pdf file on your laptop, the pdf file that is a copy thereof on my laptop
example of usage: the sequence of this protein molecule; the sequence that is a copy thereof in that protein molecule.
textual definition: A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.
textual definition: b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
imported from: cl.owl
imported from: dron.owl
imported from: envo.owl
imported from: mondo.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
imported from: ogms.owl
imported from: omrse.owl
imported from: vo.owl
has associated axiom(fol): (iff (GenericallyDependentContinuant a) (and (Continuant a) (exists (b t) (genericallyDependsOnAt a b t)))) // axiom label in BFO2 CLIF: [074-001]
comment: A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.

function
type: Class
subclass of: disposition
BFO OWL specification label: function
BFO CLIF specification label: Function
example of usage: the function of a hammer to drive in nails
example of usage: the function of a heart pacemaker to regulate the beating of a heart through electricity
example of usage: the function of amylase in saliva to break down starch into sugar
editor note: BFO 2 Reference: In the past, we have distinguished two varieties of function, artifactual function and biological function. These are not asserted subtypes of BFO:function however, since the same function – for example: to pump, to transport – can exist both in artifacts and in biological entities. The asserted subtypes of function that would be needed in order to yield a separate monoheirarchy are not artifactual function, biological function, etc., but rather transporting function, pumping function, etc.
imported from: obi.owl
imported from: omrse.owl
imported from: vo.owl
elucidation: A function is a disposition that exists in virtue of the bearer’s physical make-up and this physical make-up is something the bearer possesses because it came into being, either through evolution (in the case of natural biological entities) or through intentional design (in the case of artifacts), in order to realize processes of a certain sort. (axiom label in BFO2 Reference: [064-001])
has associated axiom(fol): (forall (x) (if (Function x) (Disposition x))) // axiom label in BFO2 CLIF: [064-001]

process boundary
type: Class
subclass of: occurrent
subclass of: Restriction
  on property: exists at
  all values from: zero-dimensional temporal region
subclass of: Restriction
  on property: has occurrent part
  all values from: process boundary
subclass of: Restriction
  on property: occupies spatiotemporal region
  all values from: Class
    intersection of: spatiotemporal region
    intersection of: Restriction
      on property: temporal part of
      some values from: spatiotemporal region
subclass of: Restriction
  on property: part of occurrent
  all values from: Class
    union of: process
    union of: process boundary
BFO OWL specification label: p-boundary
BFO CLIF specification label: ProcessBoundary
example of usage: the boundary between the 2nd and 3rd year of your life.
textual definition: p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001])
imported from: ogg.owl
has associated axiom(nl): Every process boundary occupies_temporal_region a zero-dimensional temporal region. (axiom label in BFO2 Reference: [085-002])
has associated axiom(fol): (forall (x) (if (ProcessBoundary x) (exists (y) (and (ZeroDimensionalTemporalRegion y) (occupiesTemporalRegion x y))))) // axiom label in BFO2 CLIF: [085-002]
has associated axiom(fol): (iff (ProcessBoundary a) (exists (p) (and (Process p) (temporalPartOf a p) (not (exists (b) (properTemporalPartOf b a)))))) // axiom label in BFO2 CLIF: [084-001]

one-dimensional temporal region
type: Class
subclass of: temporal region
BFO OWL specification label: 1d-t-region
BFO CLIF specification label: OneDimensionalTemporalRegion
example of usage: the temporal region during which a process occurs.
editor note: BFO 2 Reference: A temporal interval is a special kind of one-dimensional temporal region, namely one that is self-connected (is without gaps or breaks).
imported from: obi.owl
imported from: obib.owl
elucidation: A one-dimensional temporal region is a temporal region that is extended. (axiom label in BFO2 Reference: [103-001])
has associated axiom(fol): (forall (x) (if (OneDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [103-001]

material entity
type: Class
subclass of: independent continuant
BFO OWL specification label: material
BFO CLIF specification label: MaterialEntity
editor preferred label: material entity
example of usage: a flame
example of usage: a forest fire
example of usage: a human being
example of usage: a hurricane
example of usage: a photon
example of usage: a puff of smoke
example of usage: a sea wave
example of usage: a tornado
example of usage: an aggregate of human beings.
example of usage: an energy wave
example of usage: an epidemic
example of usage: the undetached arm of a human being
textual definition: An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
editor note: BFO 2 Reference: Material entities (continuants) can preserve their identity even while gaining and losing material parts. Continuants are contrasted with occurrents, which unfold themselves in successive temporal parts or phases [60
editor note: BFO 2 Reference: Object, Fiat Object Part and Object Aggregate are not intended to be exhaustive of Material Entity. Users are invited to propose new subcategories of Material Entity.
editor note: BFO 2 Reference: ‘Matter’ is intended to encompass both mass and energy (we will address the ontological treatment of portions of energy in a later version of BFO). A portion of matter is anything that includes elementary particles among its proper or improper parts: quarks and leptons, including electrons, as the smallest particles thus far discovered; baryons (including protons and neutrons) at a higher level of granularity; atoms and molecules at still higher levels, forming the cells, organs, organisms and other material entities studied by biologists, the portions of rock studied by geologists, the fossils studied by paleontologists, and so on.Material entities are three-dimensional entities (entities extended in three spatial dimensions), as contrasted with the processes in which they participate, which are four-dimensional entities (entities extended also along the dimension of time).According to the FMA, material entities may have immaterial entities as parts – including the entities identified below as sites; for example the interior (or ‘lumen’) of your small intestine is a part of your body. BFO 2.0 embodies a decision to follow the FMA here.
imported from: BFO
imported from: bfo.owl
imported from: cl.owl
imported from: dron.owl
imported from: envo.owl
imported from: hp.owl
imported from: ido.owl
imported from: mondo.owl
imported from: oae.owl
imported from: obi.owl
imported from: obib.owl
imported from: ogg.owl
imported from: omrse.owl
imported from: pr.owl
imported from: ro.owl
imported from: uberon.owl
imported from: vo.owl
elucidation: A material entity is an independent continuant that has some portion of matter as proper or improper continuant part. (axiom label in BFO2 Reference: [019-002])
has associated axiom(nl): Every entity which has a material entity as continuant part is a material entity. (axiom label in BFO2 Reference: [020-002])
has associated axiom(nl): every entity of which a material entity is continuant part is also a material entity. (axiom label in BFO2 Reference: [021-002])
has associated axiom(fol): (forall (x) (if (MaterialEntity x) (IndependentContinuant x))) // axiom label in BFO2 CLIF: [019-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt x y t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [021-002]
has associated axiom(fol): (forall (x) (if (and (Entity x) (exists (y t) (and (MaterialEntity y) (continuantPartOfAt y x t)))) (MaterialEntity x))) // axiom label in BFO2 CLIF: [020-002]
has_obo_namespace: bfo
id: BFO:0000040

immaterial entity
type: Class
subclass of: independent continuant
subclass of: Restriction
  on property: has continuant part at some time
  all values from: immaterial entity
subclass of: Restriction
  on property: has continuant part at some time
  all values from: Class
    complement of: material entity
subclass of: Restriction
  on property: has continuant part at all times that part exists
  all values from: immaterial entity
subclass of: Restriction
  on property: has continuant part at all times that part exists
  all values from: Class
    complement of: material entity
BFO OWL specification label: immaterial
BFO CLIF specification label: ImmaterialEntity
editor note: BFO 2 Reference: Immaterial entities are divided into two subgroups:boundaries and sites, which bound, or are demarcated in relation, to material entities, and which can thus change location, shape and size and as their material hosts move or change shape or size (for example: your nasal passage; the hold of a ship; the boundary of Wales (which moves with the rotation of the Earth) [38, 7, 10
imported from: cl.owl
imported from: envo.owl
imported from: hp.owl
imported from: iao.owl
imported from: mondo.owl
imported from: obi.owl
imported from: ogg.owl
imported from: omrse.owl
imported from: vo.owl

process profile
type: Class
subclass of: process
BFO OWL specification label: process-profile
BFO CLIF specification label: ProcessProfile
example of usage: On a somewhat higher level of complexity are what we shall call rate process profiles, which are the targets of selective abstraction focused not on determinate quality magnitudes plotted over time, but rather on certain ratios between these magnitudes and elapsed times. A speed process profile, for example, is represented by a graph plotting against time the ratio of distance covered per unit of time. Since rates may change, and since such changes, too, may have rates of change, we have to deal here with a hierarchy of process profile universals at successive levels
example of usage: One important sub-family of rate process profiles is illustrated by the beat or frequency profiles of cyclical processes, illustrated by the 60 beats per minute beating process of John’s heart, or the 120 beats per minute drumming process involved in one of John’s performances in a rock band, and so on. Each such process includes what we shall call a beat process profile instance as part, a subtype of rate process profile in which the salient ratio is not distance covered but rather number of beat cycles per unit of time. Each beat process profile instance instantiates the determinable universal beat process profile. But it also instantiates multiple more specialized universals at lower levels of generality, selected from rate process profilebeat process profileregular beat process profile3 bpm beat process profile4 bpm beat process profileirregular beat process profileincreasing beat process profileand so on.In the case of a regular beat process profile, a rate can be assigned in the simplest possible fashion by dividing the number of cycles by the length of the temporal region occupied by the beating process profile as a whole. Irregular process profiles of this sort, for example as identified in the clinic, or in the readings on an aircraft instrument panel, are often of diagnostic significance.
example of usage: The simplest type of process profiles are what we shall call ‘quality process profiles’, which are the process profiles which serve as the foci of the sort of selective abstraction that is involved when measurements are made of changes in single qualities, as illustrated, for example, by process profiles of mass, temperature, aortic pressure, and so on.
textual definition: b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002])
imported from: mondo.owl
imported from: obi.owl
elucidation: b process_profile_of c holds when b proper_occurrent_part_of c& there is some proper_occurrent_part d of c which has no parts in common with b & is mutually dependent on b& is such that b, c and d occupy the same temporal region (axiom label in BFO2 Reference: [094-005])
has associated axiom(fol): (forall (x y) (if (processProfileOf x y) (and (properContinuantPartOf x y) (exists (z t) (and (properOccurrentPartOf z y) (TemporalRegion t) (occupiesSpatioTemporalRegion x t) (occupiesSpatioTemporalRegion y t) (occupiesSpatioTemporalRegion z t) (not (exists (w) (and (occurrentPartOf w x) (occurrentPartOf w z))))))))) // axiom label in BFO2 CLIF: [094-005]
has associated axiom(fol): (iff (ProcessProfile a) (exists (b) (and (Process b) (processProfileOf a b)))) // axiom label in BFO2 CLIF: [093-002]

zero-dimensional temporal region
type: Class
subclass of: temporal region
subclass of: Restriction
  on property: has proper occurrent part
  all values from: Nothing
BFO OWL specification label: 0d-t-region
BFO CLIF specification label: ZeroDimensionalTemporalRegion
example of usage: a temporal region that is occupied by a process boundary
example of usage: right now
example of usage: the moment at which a child is born
example of usage: the moment at which a finger is detached in an industrial accident
example of usage: the moment of death.
alternative term: temporal instant.
imported from: obi.owl
imported from: ogg.owl
elucidation: A zero-dimensional temporal region is a temporal region that is without extent. (axiom label in BFO2 Reference: [102-001])
has associated axiom(fol): (forall (x) (if (ZeroDimensionalTemporalRegion x) (TemporalRegion x))) // axiom label in BFO2 CLIF: [102-001]

history
type: Class
subclass of: process
BFO OWL specification label: history
BFO CLIF specification label: History
imported from: obi.owl
elucidation: A history is a process that is the sum of the totality of processes taking place in the spatiotemporal region occupied by a material entity or site, including processes on the surface of the entity or within the cavities to which it serves as host. (axiom label in BFO2 Reference: [138-001])

anatomical entity
type: Class
subclass of: biological entity
imported from: caro.owl
imported from: cl.owl
imported from: mondo.owl

connected anatomical structure
type: Class
subclass of: material anatomical entity
imported from: caro.owl
imported from: mondo.owl

material anatomical entity
type: Class
subclass of: material entity
subclass of: anatomical entity
subclass of: Restriction
  on property: drains
  all values from: connected anatomical structure
imported from: caro.owl
imported from: mondo.owl

immaterial anatomical entity
type: Class
subclass of: immaterial entity
imported from: mondo.owl

multi-cell-part structure
type: Class
subclass of: connected anatomical structure
imported from: caro.owl
imported from: mondo.owl

neuron projection bundle
type: Class
subclass of: multi-cell-part structure
imported from: caro.owl
imported from: mondo.owl

organism or virus or viroid
type: Class
subclass of: PCO_0000031
textual definition: Material anatomical entity that is a member of an individual species or is a viral or viroid particle.
imported from: envo.owl
imported from: mondo.owl

multicellular anatomical structure
type: Class
subclass of: connected anatomical structure
subclass of: UBERON_0000061
subclass of: Restriction
  on property: directly develops from
  all values from: multicellular anatomical structure
imported from: caro.owl
imported from: mondo.owl

biological entity
type: Class
subclass of: independent continuant
imported from: mondo.owl

electron
type: Class
subclass of: lepton
textual definition: Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: KEGG:C05359
database_cross_reference: Wikipedia:Electron
has_exact_synonym: electron
has_related_synonym: Elektron
has_related_synonym: beta
has_related_synonym: beta(-)
has_related_synonym: beta-particle
has_related_synonym: e
has_related_synonym: e(-)
has_related_synonym: e-
has_related_synonym: negatron
id: CHEBI:10545
in subset: 3 STAR

hyaluronate
type: Class
subclass of: polyanionic polymer
subclass of: carbohydrate acid derivative anion
subclass of: Restriction
  on property: is conjugate base of
  some values from: hyaluronic acid
textual definition: A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3.
imported from: hp.owl
has_related_synonym: hyaluronan
has_related_synonym: hyaluronate polyanion
id: CHEBI:132153
in subset: 3 STAR

antihypotensive agent
type: Class
subclass of: role
textual definition: A cardiovascular drug that tends to raise reduced blood pressure.
imported from: chebi.owl
database_cross_reference: Wikipedia:Antihypotensive_agent
has_obo_namespace: chebi_ontology
has_related_synonym: antihypotensive agents
has_related_synonym: pressor
has_related_synonym: pressors
has_related_synonym: vasopressor agens
has_related_synonym: vasopressor agent
id: CHEBI:137431
in subset: 3 STAR

endocrine disruptor
type: Class
subclass of: hormone receptor modulator
textual definition: Any compound that can disrupt the functions of the endocrine (hormone) system
imported from: mondo.owl
has_related_synonym: endocrine disrupting chemical
has_related_synonym: endocrine disrupting chemicals
has_related_synonym: endocrine disrupting compound
has_related_synonym: endocrine disrupting compounds
has_related_synonym: endocrine disruptors
has_related_synonym: endocrine-disrupting chemical
has_related_synonym: endocrine-disrupting chemicals
has_related_synonym: hormonally active agent
has_related_synonym: hormonally active agents

gas molecular entity
type: Class
subclass of: main group molecular entity
textual definition: Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa).
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: Wikipedia:https://en.wikipedia.org/wiki/Gas
has_related_synonym: gas molecular entities
has_related_synonym: gaseous molecular entities
has_related_synonym: gaseous molecular entity
id: CHEBI:138675
in subset: 3 STAR

carbamate
type: Class
subclass of: amino-acid anion
subclass of: Restriction
  on property: is conjugate base of
  some values from: carbamic acid
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: carbamate
has_related_synonym: Carbamat
has_related_synonym: Karbamat
has_related_synonym: carbamate ion
has_related_synonym: carbamic acid, ion(1-)
id: CHEBI:13941
in subset: 3 STAR

alpha-hydroxy ketone
type: Class
subclass of: alcohol
subclass of: alpha-oxyketone
textual definition: An alpha-oxyketone that has a hydroxy group as the alpha-oxy moiety.
imported from: mondo.owl
has_related_synonym: alpha-hydroxy ketones
has_related_synonym: alpha-hydroxy-ketone
has_related_synonym: alpha-hydroxy-ketones
has_related_synonym: alpha-hydroxyketone
has_related_synonym: alpha-hydroxyketones

tertiary alpha-hydroxy ketone
type: Class
subclass of: alpha-hydroxy ketone
subclass of: tertiary alcohol
textual definition: An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing two organyl groups.
imported from: mondo.owl
has_related_synonym: tertiary alpha-hydroxy ketones
has_related_synonym: tertiary alpha-hydroxy-ketone
has_related_synonym: tertiary alpha-hydroxy-ketones
has_related_synonym: tertiary alpha-hydroxyketone
has_related_synonym: tertiary alpha-hydroxyketones

a tetracycline zwittterion
type: Class
subclass of: tetracyclines
imported from: mondo.owl
has_related_synonym: a tetracycline

acceptor
type: Class
subclass of: chemical role
textual definition: A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:13699
has_alternative_id: CHEBI:2377
database_cross_reference: KEGG:C00028
database_cross_reference: KEGG:C16722
has_exact_synonym: Acceptor
has_related_synonym: A
has_related_synonym: Akzeptor
has_related_synonym: Hydrogen-acceptor
has_related_synonym: Oxidized donor
has_related_synonym: accepteur
id: CHEBI:15339
in subset: 3 STAR

primary alcohol
type: Class
subclass of: alcohol
textual definition: A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
imported from: mondo.owl
has_exact_synonym: Primary alcohol
has_related_synonym: 1-Alcohol
has_related_synonym: a primary alcohol
has_related_synonym: primary alcohols

polypeptide
type: Class
subclass of: peptide
subclass of: macromolecule
textual definition: A peptide containing ten or more amino acid residues.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:14860
has_alternative_id: CHEBI:8314
database_cross_reference: KEGG:C00403
has_exact_synonym: Polypeptide
has_exact_synonym: polypeptides
has_related_synonym: Polypeptid
has_related_synonym: polipeptido
id: CHEBI:15841
in subset: 3 STAR

ammonia
type: Class
subclass of: gas molecular entity
subclass of: azane
subclass of: mononuclear parent hydride
subclass of: Restriction
  on property: has role
  some values from: NMR chemical shift reference compound
subclass of: Restriction
  on property: has role
  some values from: metabolite
subclass of: Restriction
  on property: has role
  some values from: neurotoxin
subclass of: Restriction
  on property: has role
  some values from: nucleophilic reagent
subclass of: Restriction
  on property: has role
  some values from: mouse metabolite
subclass of: Restriction
  on property: has role
  some values from: EC 3.5.1.4 (amidase) inhibitor
subclass of: Restriction
  on property: has role
  some values from: refrigerant
subclass of: Restriction
  on property: is conjugate acid of
  some values from: azanide
subclass of: Restriction
  on property: is conjugate base of
  some values from: ammonium
textual definition: An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:13405
has_alternative_id: CHEBI:13406
has_alternative_id: CHEBI:13407
has_alternative_id: CHEBI:13771
has_alternative_id: CHEBI:22533
has_alternative_id: CHEBI:44269
has_alternative_id: CHEBI:44284
has_alternative_id: CHEBI:44404
has_alternative_id: CHEBI:7434
database_cross_reference: HMDB:HMDB0000051
database_cross_reference: KEGG:C00014
database_cross_reference: KEGG:D02916
database_cross_reference: KNApSAcK:C00007267
database_cross_reference: MetaCyc:AMMONIA
database_cross_reference: MolBase:930
database_cross_reference: PDBeChem:NH3
database_cross_reference: Wikipedia:Ammonia
has_exact_synonym: AMMONIA
has_exact_synonym: Ammonia
has_exact_synonym: ammonia
has_exact_synonym: azane
has_related_synonym: Ammoniak
has_related_synonym: NH3
has_related_synonym: R-717
has_related_synonym: [NH3]
has_related_synonym: ammoniac
has_related_synonym: amoniaco
has_related_synonym: spirit of hartshorn
id: CHEBI:16134
in subset: 3 STAR

hyaluronic acid
type: Class
subclass of: mucopolysaccharide
subclass of: exopolysaccharide
subclass of: Restriction
  on property: has role
  some values from: human metabolite
subclass of: Restriction
  on property: is conjugate acid of
  some values from: hyaluronate
textual definition: A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.
imported from: cl.owl
imported from: hp.owl
has_alternative_id: CHEBI:14412
has_alternative_id: CHEBI:24622
has_alternative_id: CHEBI:24623
has_alternative_id: CHEBI:5772
database_cross_reference: HMDB:HMDB0010366
database_cross_reference: KEGG:C00518
database_cross_reference: KEGG:D08043
database_cross_reference: KEGG:G10505
database_cross_reference: Wikipedia:Hyaluronan
has_exact_synonym: Hyaluronic acid
has_related_synonym: Hyaluronsaeure
has_related_synonym: [beta-D-glucopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]n
has_related_synonym: [beta-N-Acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)]n
has_related_synonym: acide hyaluronique
has_related_synonym: acido hialuronico
has_related_synonym: hyaluronan
id: CHEBI:16336
in subset: 3 STAR

protein polypeptide chain
type: Class
subclass of: polypeptide
subclass of: Restriction
  on property: has part
  some values from: proteinogenic amino-acid residue
textual definition: A naturally occurring polypeptide synthesized at the ribosome.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:8526
database_cross_reference: KEGG:C00017
has_related_synonym: Protein
has_related_synonym: a protein
has_related_synonym: polypeptide chain
has_related_synonym: protein polypeptide chains
id: CHEBI:16541
in subset: 3 STAR

carbohydrate
type: Class
subclass of: carbohydrates and carbohydrate derivatives
textual definition: Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.
imported from: hp.owl
has_alternative_id: CHEBI:15131
has_alternative_id: CHEBI:23008
has_alternative_id: CHEBI:9318
database_cross_reference: Wikipedia:Carbohydrate
has_exact_synonym: carbohydrate
has_exact_synonym: carbohydrates
has_related_synonym: Kohlenhydrat
has_related_synonym: Kohlenhydrate
has_related_synonym: a carbohydrate
has_related_synonym: carbohidrato
has_related_synonym: carbohidratos
has_related_synonym: glucide
has_related_synonym: glucides
has_related_synonym: glucido
has_related_synonym: glucidos
has_related_synonym: hydrates de carbone
has_related_synonym: saccharide
has_related_synonym: saccharides
has_related_synonym: saccharidum
id: CHEBI:16646
in subset: 3 STAR

peptide
type: Class
subclass of: macromolecule
subclass of: carboxamide
subclass of: organic amino compound
subclass of: Restriction
  on property: has part
  some values from: amino-acid residue
subclass of: Restriction
  on property: is tautomer of
  some values from: peptide zwitterion
editor preferred label: peptide
textual definition: Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.
imported from: chebi.owl
imported from: hp.owl
imported from: mondo.owl
imported from: obi.owl
has_alternative_id: CHEBI:14753
has_alternative_id: CHEBI:25906
has_alternative_id: CHEBI:7990
database_cross_reference: KEGG:C00012
has_exact_synonym: Peptide
has_exact_synonym: peptides
has_related_synonym: Peptid
has_related_synonym: peptido
has_related_synonym: peptidos
id: CHEBI:16670
in subset: 3 STAR

glycan
type: Class
subclass of: carbohydrates and carbohydrate derivatives
textual definition: Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001.
imported from: hp.owl
has_related_synonym: glycans
id: CHEBI:167559
in subset: 3 STAR

formaldehyde
type: Class
subclass of: molecular entity
textual definition: An aldehyde resulting from the formal oxidation of methanol.
imported from: chebi.owl
imported from: vo.owl
charge: 0
formula: CH2O
inchi: InChI=1S/CH2O/c1-2/h1H2
inchikey: WSFSSNUMVMOOMR-UHFFFAOYSA-N
mass: 30.02598
monoisotopicmass: 30.01056
smiles: [H]C([H])=O
has_alternative_id: CHEBI:14274
has_alternative_id: CHEBI:24077
has_alternative_id: CHEBI:337763
has_alternative_id: CHEBI:5142
database_cross_reference: Beilstein:1209228
database_cross_reference: CAS:50-00-0
database_cross_reference: DrugBank:DB03843
database_cross_reference: Drug_Central:3244
database_cross_reference: Gmelin:445
database_cross_reference: HMDB:HMDB0001426
database_cross_reference: KEGG:C00067
database_cross_reference: KEGG:D00017
database_cross_reference: MetaCyc:FORMALDEHYDE
database_cross_reference: PDBeChem:FOR
database_cross_reference: PMID:110589
database_cross_reference: PMID:12686735
database_cross_reference: PMID:15091529
database_cross_reference: PMID:16423181
database_cross_reference: PMID:17618393
database_cross_reference: PMID:18837732
database_cross_reference: PMID:25042713
database_cross_reference: PMID:7381846
database_cross_reference: PMID:7548723
database_cross_reference: PMID:7689168
database_cross_reference: PMID:7896413
database_cross_reference: PMID:9686972
database_cross_reference: PPDB:359
database_cross_reference: Reaxys:1209228
database_cross_reference: UM-BBD_compID:c0122
database_cross_reference: Wikipedia:Formaldehyde
has_exact_synonym: FORMALDEHYDE
has_exact_synonym: Formaldehyde
has_exact_synonym: formaldehyde
has_obo_namespace: chebi_ontology
has_related_synonym: FORMALIN
has_related_synonym: Formaldehyd
has_related_synonym: Formalin
has_related_synonym: Methanal
has_related_synonym: Methylene oxide
has_related_synonym: Oxomethane
has_related_synonym: Oxomethylene
id: CHEBI:16842
in subset: 3 STAR

ketone
type: Class
subclass of: carbonyl compound
textual definition: A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H).
imported from: mondo.owl
has_exact_synonym: Ketone
has_exact_synonym: ketones
has_related_synonym: Keton
has_related_synonym: R-CO-R'
has_related_synonym: a ketone
has_related_synonym: cetone
has_related_synonym: ketones

penicillin
type: Class
subclass of: penicillanic acids
textual definition: Any member of the group of substituted penams containing two methyl substituents at position 2, a carboxylate substituent at position 3 and a carboxamido group at position 6.
imported from: chebi.owl
imported from: dron.owl
charge: 0
formula: C9H11N2O4SR
mass: 243.26000
monoisotopicmass: 243.04395
has_alternative_id: CHEBI:14742
has_alternative_id: CHEBI:25869
has_alternative_id: CHEBI:7961
database_cross_reference: CiteXplore:12833570
database_cross_reference: CiteXplore:1502708
database_cross_reference: CiteXplore:16033609
database_cross_reference: CiteXplore:7798534
database_cross_reference: KEGG COMPOUND:C00395
database_cross_reference: KEGG:C00395
database_cross_reference: PMID:11851248
database_cross_reference: PMID:12833570
database_cross_reference: PMID:1502708
database_cross_reference: PMID:16033609
database_cross_reference: PMID:7061385
database_cross_reference: PMID:7798534
database_cross_reference: Wikipedia:Penicillin
has_exact_synonym: Penicillin
has_exact_synonym: penicillin
has_exact_synonym: penicillins
has_obo_namespace: chebi_ontology
has_related_synonym: C9H11N2O4SR
has_related_synonym: penicillins
id: CHEBI:17334
in subset: 3 STAR

donor
type: Class
subclass of: chemical role
textual definition: A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:14202
has_alternative_id: CHEBI:4697
database_cross_reference: KEGG:C01351
has_exact_synonym: Donor
has_related_synonym: Donator
has_related_synonym: donneur
id: CHEBI:17891
in subset: 3 STAR

lipid
type: Class
subclass of: organic molecular entity
textual definition: 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.
imported from: mondo.owl
has_exact_synonym: Lipid
has_exact_synonym: lipids

glycosaminoglycan
type: Class
subclass of: aminoglycan
textual definition: Any polysaccharide containing a substantial proportion of aminomonosaccharide residues.
imported from: hp.owl
has_alternative_id: CHEBI:14361
has_alternative_id: CHEBI:24398
has_alternative_id: CHEBI:5495
database_cross_reference: KEGG:C02545
database_cross_reference: Wikipedia:Glycosaminoglycan
has_exact_synonym: Glycosaminoglycan
has_exact_synonym: glycosaminoglycan
has_related_synonym: Glykosaminoglykan
has_related_synonym: glicosaminoglicano
has_related_synonym: glycosaminoglycane
has_related_synonym: glycosaminoglycans
id: CHEBI:18085
in subset: 3 STAR

polysaccharide
type: Class
subclass of: carbohydrate
subclass of: glycan
subclass of: biomacromolecule
textual definition: A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues.
imported from: hp.owl
has_alternative_id: CHEBI:14864
has_alternative_id: CHEBI:26205
has_alternative_id: CHEBI:8322
database_cross_reference: KEGG:C00420
has_exact_synonym: Polysaccharide
has_exact_synonym: polysaccharides
has_related_synonym: Glycan
has_related_synonym: Glycane
has_related_synonym: Glykan
has_related_synonym: Glykane
has_related_synonym: glycans
has_related_synonym: polisacarido
has_related_synonym: polisacaridos
id: CHEBI:18154
in subset: 3 STAR

iron atom
type: Class
subclass of: iron group element atom
subclass of: Restriction
  on property: has role
  some values from: micronutrient
subclass of: Restriction
  on property: has role
  some values from: Escherichia coli metabolite
textual definition: An iron group element atom that has atomic number 26.
imported from: mondo.owl
has_exact_synonym: iron
has_related_synonym: 26Fe
has_related_synonym: Eisen
has_related_synonym: Fe
has_related_synonym: Iron
has_related_synonym: fer
has_related_synonym: ferrum
has_related_synonym: hierro
has_related_synonym: iron

acyl group
type: Class
subclass of: organic group
textual definition: An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: acyl group
has_exact_synonym: alkanoyl
has_related_synonym: acyl groups
has_related_synonym: alkanoyl group
has_related_synonym: groupe acyle
id: CHEBI:22221
in subset: 3 STAR

alkaline earth metal atom
type: Class
subclass of: main group element atom
subclass of: metal atom
subclass of: s-block element atom
imported from: hp.owl
has_exact_synonym: alkaline earth metals
has_related_synonym: Erdalkalimetall
has_related_synonym: Erdalkalimetalle
has_related_synonym: alkaline earth metal
has_related_synonym: alkaline-earth metal
has_related_synonym: alkaline-earth metals
has_related_synonym: metal alcalino-terreux
has_related_synonym: metal alcalinoterreo
has_related_synonym: metales alcalinoterreos
has_related_synonym: metaux alcalino-terreux
id: CHEBI:22313
in subset: 3 STAR

aminoglycan
type: Class
subclass of: organonitrogen compound
subclass of: polysaccharide derivative
imported from: hp.owl
has_related_synonym: aminoglycans
id: CHEBI:22506
in subset: 3 STAR

anion
type: Class
subclass of: ion
textual definition: A monoatomic or polyatomic species having one or more elementary charges of the electron.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: Anion
has_exact_synonym: anion
has_related_synonym: Anionen
has_related_synonym: aniones
has_related_synonym: anions
id: CHEBI:22563
in subset: 3 STAR

base
type: Class
subclass of: chemical role
textual definition: A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base).
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: KEGG:C00701
has_exact_synonym: Base
has_exact_synonym: base
has_related_synonym: Base1
has_related_synonym: Base2
has_related_synonym: Basen
has_related_synonym: Nucleobase
has_related_synonym: bases
id: CHEBI:22695
in subset: 3 STAR

NMR chemical shift reference compound
type: Class
subclass of: application
subclass of: chemical role
textual definition: Any compound that produces a peak used to reference an NMR spectrum during data pre-processing.
imported from: hp.owl
has_related_synonym: NMR chemical shift reference compounds
has_related_synonym: NMR chemical shift standard
has_related_synonym: NMR chemical shift standards
has_related_synonym: NMR internal standard
has_related_synonym: NMR internal standards
has_related_synonym: NMR reference standard
has_related_synonym: NMR reference standards
id: CHEBI:228364
in subset: 3 STAR

calcium atom
type: Class
subclass of: alkaline earth metal atom
subclass of: Restriction
  on property: has role
  some values from: macronutrient
imported from: hp.owl
database_cross_reference: DrugBank:DB01373
database_cross_reference: KEGG:C00076
database_cross_reference: WebElements:Ca
has_exact_synonym: calcium
has_related_synonym: 20Ca
has_related_synonym: Ca
has_related_synonym: Calcium
has_related_synonym: Kalzium
has_related_synonym: calcio
has_related_synonym: calcium
id: CHEBI:22984
in subset: 3 STAR

carbamoyl group
type: Class
subclass of: univalent carboacyl group
subclass of: Restriction
  on property: is substituent group from
  some values from: carbamic acid
textual definition: The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: carbamoyl
has_related_synonym: -C(O)NH2
has_related_synonym: -CONH2
has_related_synonym: aminocarbonyl
has_related_synonym: carbamyl
has_related_synonym: carbamyl group
has_related_synonym: carboxamide
id: CHEBI:23004
in subset: 3 STAR

carbonyl group
type: Class
subclass of: organodiyl group
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: carbonyl
has_exact_synonym: carbonyl group
has_related_synonym: >C=O
id: CHEBI:23019
in subset: 3 STAR

cephalosporin
type: Class
subclass of: cephem
textual definition: A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring.
textual definition: A class of beta-lactam antibiotics differing from the penicillins in having a 6-membered, rather than a 5-membered, side ring. Although cephalosporins are among the most commonly used antibiotics in the treatment of routine infections, and their use is increasing over time, they can cause a range of hypersensitivity reactions, from mild, delayed-onset cutaneous reactions to life-threatening anaphylaxis in patients with immunoglobulin E (IgE)-mediated allergy.
imported from: chebi.owl
imported from: dron.owl
charge: 0
formula: C7H5NO3SR2
mass: 183.18500
monoisotopicmass: 182.99901
has_alternative_id: CHEBI:3538
database_cross_reference: CiteXplore:12833570
database_cross_reference: CiteXplore:6762896
database_cross_reference: KEGG COMPOUND:C00875
database_cross_reference: KEGG:C00875
database_cross_reference: PMID:10069359
database_cross_reference: PMID:11936371
database_cross_reference: PMID:12833570
database_cross_reference: PMID:24269048
database_cross_reference: PMID:3320614
database_cross_reference: PMID:6762896
database_cross_reference: PMID:8426246
database_cross_reference: Wikipedia:Cephalosporin
has_exact_synonym: Cephalosporin
has_obo_namespace: chebi_ontology
has_related_synonym: C7H5NO3SR2
has_related_synonym: cephalosphorin
has_related_synonym: cephalosphorins
has_related_synonym: cephalosporins
id: CHEBI:23066
in subset: 3 STAR

cobalamins
type: Class
subclass of: cobamides
imported from: mondo.owl

cobamides
type: Class
subclass of: cobalt-corrinoid hexaamide
imported from: mondo.owl

cofactor
type: Class
subclass of: biochemical role
textual definition: An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: Wikipedia:Cofactor_(biochemistry)
has_exact_synonym: cofactor
has_exact_synonym: cofactors
id: CHEBI:23357
in subset: 3 STAR

molecular entity
type: Class
subclass of: object
subclass of: material entity
subclass of: chemical entity
editor preferred label: molecular entity
textual definition: Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
editor note: We are assuming that every molecular entity has to be completely connected by chemical bonds. This excludes protein complexes, which are comprised of minimally two separate molecular entities. We will follow up with Chebi to ensure this is their understanding as well
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
imported from: obi.owl
imported from: pr.owl
imported from: vo.owl
has_exact_synonym: molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: entidad molecular
has_related_synonym: entidades moleculares
has_related_synonym: entite moleculaire
has_related_synonym: molecular entities
has_related_synonym: molekulare Entitaet
id: CHEBI:23367
in subset: 3 STAR

cobalt-corrinoid hexaamide
type: Class
subclass of: cobalt corrinoid
imported from: mondo.owl

cyclic amide
type: Class
subclass of: amide
imported from: dron.owl
has_exact_synonym: cyclic amide
has_related_synonym: cyclic amides
id: CHEBI:23443

drug
type: Class
subclass of: pharmaceutical
textual definition: Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
imported from: mondo.owl
has_related_synonym: drugs
has_related_synonym: medicine

enzyme inhibitor
type: Class
subclass of: inhibitor
subclass of: biochemical role
textual definition: A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: enzyme inhibitor
has_related_synonym: enzyme inhibitors
has_related_synonym: inhibidor enzimatico
has_related_synonym: inhibidores enzimaticos
has_related_synonym: inhibiteur enzymatique
has_related_synonym: inhibiteurs enzymatiques
id: CHEBI:23924
in subset: 3 STAR

glucocorticoid
type: Class
subclass of: corticosteroid hormone
textual definition: Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood.
imported from: mondo.owl
has_related_synonym: glucocorticoids

chemical entity
type: Class
subclass of: material entity
textual definition: A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.
imported from: chebi.owl
imported from: cl.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
imported from: vo.owl
has_exact_synonym: chemical entity
has_obo_namespace: chebi_ontology
id: CHEBI:24431
in subset: 3 STAR

biological role
type: Class
subclass of: role
textual definition: A role played by the molecular entity or part thereof within a biological context.
imported from: chebi.owl
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: biological function
id: CHEBI:24432
in subset: 3 STAR

group
type: Class
subclass of: chemical entity
subclass of: Restriction
  on property: has part
  some values from: atom
textual definition: A defined linked collection of atoms or a single atom within a molecular entity.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: group
has_related_synonym: Gruppe
has_related_synonym: Rest
has_related_synonym: groupe
has_related_synonym: grupo
has_related_synonym: grupos
id: CHEBI:24433
in subset: 3 STAR

heterocyclic antibiotic
type: Class
subclass of: organic heterocyclic compound
imported from: dron.owl
id: CHEBI:24531

organic heterocyclic compound
type: Class
subclass of: heteroorganic entity
subclass of: organic cyclic compound
subclass of: heterocyclic compound
textual definition: A cyclic compound having as ring members atoms of carbon and at least of one other element.
imported from: chebi.owl
imported from: dron.owl
imported from: mondo.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic heterocycle
has_related_synonym: organic heterocyclic compounds
id: CHEBI:24532
in subset: 3 STAR

hormone
type: Class
subclass of: molecular messenger
subclass of: agonist
textual definition: Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
imported from: mondo.owl
has_related_synonym: endocrine
has_related_synonym: hormones

hydrocarbon
type: Class
subclass of: organic fundamental parent
textual definition: A compound consisting of carbon and hydrogen only.
imported from: mondo.owl
has_exact_synonym: hydrocarbon
has_exact_synonym: hydrocarbons
has_related_synonym: Kohlenwasserstoff
has_related_synonym: Kohlenwasserstoffe
has_related_synonym: hidrocarburo
has_related_synonym: hidrocarburos
has_related_synonym: hydrocarbure

hydroxides
type: Class
subclass of: oxygen molecular entity
subclass of: main group molecular entity
subclass of: hydrogen molecular entity
subclass of: polyatomic entity
subclass of: heteroatomic molecular entity
subclass of: Restriction
  on property: has part
  some values from: hydroxy group
textual definition: Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)).
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: chebi_ontology
id: CHEBI:24651
in subset: 3 STAR

oxoacid
type: Class
subclass of: hydroxides
subclass of: Restriction
  on property: has role
  some values from: Bronsted acid
textual definition: A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: oxoacid
has_exact_synonym: oxoacids
has_related_synonym: oxacids
has_related_synonym: oxiacids
has_related_synonym: oxo acid
has_related_synonym: oxy-acids
has_related_synonym: oxyacids
id: CHEBI:24833
in subset: 3 STAR

inorganic anion
type: Class
subclass of: anion
subclass of: inorganic ion
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: inorganic anions
id: CHEBI:24834
in subset: 3 STAR

inorganic molecular entity
type: Class
subclass of: molecular entity
textual definition: A molecular entity that contains no carbon.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: anorganische Verbindungen
has_related_synonym: inorganic compounds
has_related_synonym: inorganic entity
has_related_synonym: inorganic molecular entities
has_related_synonym: inorganics
id: CHEBI:24835
in subset: 3 STAR

ion
type: Class
subclass of: molecular entity
textual definition: A molecular entity having a net electric charge.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: Ion
has_exact_synonym: ion
has_related_synonym: Ionen
has_related_synonym: iones
has_related_synonym: ions
id: CHEBI:24870
in subset: 3 STAR

iron molecular entity
type: Class
subclass of: iron group molecular entity
subclass of: Restriction
  on property: has part
  some values from: iron atom
imported from: mondo.owl
has_exact_synonym: iron molecular entity
has_related_synonym: iron compounds
has_related_synonym: iron molecular entities

lactam
type: Class
subclass of: cyclic amide
subclass of: amide
subclass of: cyclic pseudoketone
subclass of: carboxamide
subclass of: organonitrogen heterocyclic compound
textual definition: Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
imported from: chebi.owl
imported from: dron.owl
has_exact_synonym: lactam
has_exact_synonym: lactams
has_obo_namespace: chebi_ontology
has_related_synonym: Laktam
has_related_synonym: Laktame
has_related_synonym: lactams
id: CHEBI:24995
in subset: 3 STAR

metabolite
type: Class
subclass of: biochemical role
textual definition: Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:26619
has_alternative_id: CHEBI:35220
has_exact_synonym: metabolite
has_related_synonym: metabolites
has_related_synonym: primary metabolites
has_related_synonym: secondary metabolites
id: CHEBI:25212
in subset: 3 STAR

metalloporphyrin
type: Class
subclass of: porphyrins
subclass of: coordination entity
subclass of: metallotetrapyrrole
imported from: mondo.owl
has_related_synonym: metalloporphyrins
has_related_synonym: metaloporphyrins

molecule
type: Class
subclass of: polyatomic entity
textual definition: Any polyatomic entity that is an electrically neutral entity consisting of more than one atom.
imported from: chebi.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: molecule
has_obo_namespace: chebi_ontology
has_related_synonym: Molekuel
has_related_synonym: molecula
has_related_synonym: molecules
has_related_synonym: neutral molecular compounds
id: CHEBI:25367
in subset: 3 STAR

nitrogen atom
type: Class
subclass of: nonmetal atom
subclass of: pnictogen
subclass of: Restriction
  on property: has role
  some values from: macronutrient
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: WebElements:N
has_exact_synonym: nitrogen
has_related_synonym: 7N
has_related_synonym: N
has_related_synonym: Stickstoff
has_related_synonym: azote
has_related_synonym: nitrogen
has_related_synonym: nitrogeno
id: CHEBI:25555
in subset: 3 STAR

organonitrogen heterocyclic antibiotic
type: Class
subclass of: heterocyclic antibiotic
subclass of: organic heterocyclic compound
subclass of: organonitrogen heterocyclic compound
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organonitrogen heterocyclic antibiotics
id: CHEBI:25558
in subset: 3 STAR

nonmetal atom
type: Class
subclass of: atom
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: nonmetal
has_related_synonym: Nichtmetall
has_related_synonym: Nichtmetalle
has_related_synonym: no metal
has_related_synonym: no metales
has_related_synonym: non-metal
has_related_synonym: non-metaux
has_related_synonym: nonmetal
has_related_synonym: nonmetals
id: CHEBI:25585
in subset: 3 STAR

organic anion
type: Class
subclass of: anion
subclass of: organic ion
textual definition: Any organic ion with a net negative charge.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: organic anions
id: CHEBI:25696
in subset: 3 STAR

organic ion
type: Class
subclass of: ion
subclass of: organic molecular entity
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: organic ions
id: CHEBI:25699
in subset: 3 STAR

oxide
type: Class
subclass of: oxygen molecular entity
subclass of: heteroatomic molecular entity
textual definition: An oxide is a chemical compound of oxygen with other chemical elements.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: oxide
has_related_synonym: oxides
id: CHEBI:25741
in subset: 3 STAR

oxygen atom
type: Class
subclass of: nonmetal atom
subclass of: chalcogen
subclass of: Restriction
  on property: has role
  some values from: macronutrient
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: KEGG:C00007
database_cross_reference: WebElements:O
has_exact_synonym: oxygen
has_related_synonym: 8O
has_related_synonym: O
has_related_synonym: Sauerstoff
has_related_synonym: oxigeno
has_related_synonym: oxygen
has_related_synonym: oxygene
id: CHEBI:25805
in subset: 3 STAR

oxygen molecular entity
type: Class
subclass of: chalcogen molecular entity
subclass of: Restriction
  on property: has part
  some values from: oxygen atom
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: oxygen molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: oxygen molecular entities
id: CHEBI:25806
in subset: 3 STAR

penicillanic acids
type: Class
subclass of: carboxylic acid
subclass of: penams
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
id: CHEBI:25865
in subset: 3 STAR

polyketide
type: Class
subclass of: organooxygen compound
textual definition: Natural and synthetic compounds containing alternating carbonyl and methylene groups ('beta-polyketones'), biogenetically derived from repeated condensation of acetyl coenzyme A (via malonyl coenzyme A), and usually the compounds derived from them by further condensations, etc. Considered by many to be synonymous with the less frequently used terms acetogenins and ketides.
imported from: mondo.owl
has_exact_synonym: polyketide
has_related_synonym: polyketides

porphyrins
type: Class
subclass of: cyclic tetrapyrrole
subclass of: Restriction
  on property: has role
  some values from: cofactor
textual definition: Natural pigments containing a fundamental skeleton of four pyrrole nuclei united through the alpha-positions by four methine groups to form a macrocyclic structure.
imported from: mondo.owl
has_exact_synonym: porphyrins

prosthetic group
type: Class
subclass of: cofactor
textual definition: A tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity.
imported from: mondo.owl
has_exact_synonym: prosthetic group
has_related_synonym: groupe prosthetique
has_related_synonym: prosthetic groups

steroid hormone
type: Class
subclass of: steroid
subclass of: Restriction
  on property: has role
  some values from: hormone
textual definition: Any steroid that acts as hormone.
imported from: mondo.owl
has_related_synonym: Steroidhormon
has_related_synonym: Steroidhormone
has_related_synonym: hormona esteroide
has_related_synonym: hormonas esteroideas
has_related_synonym: hormone steroide
has_related_synonym: hormones steroides
has_related_synonym: steroid hormones

sulfur molecular entity
type: Class
subclass of: chalcogen molecular entity
imported from: dron.owl
has_exact_synonym: sulfur molecular entity
has_related_synonym: sulfur molecular entities
id: CHEBI:26835

tertiary alcohol
type: Class
subclass of: alcohol
textual definition: A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
imported from: mondo.owl
has_exact_synonym: tertiary alcohol
has_related_synonym: tertiary alcohols

tetracyclines
type: Class
subclass of: polyketide
subclass of: Restriction
  on property: has role
  some values from: metabolite
subclass of: Restriction
  on property: has parent hydride
  some values from: tetracene
textual definition: A subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups.
imported from: mondo.owl
term replaced by: XCO_0000672
deprecated: true

tetrapyrrole
type: Class
subclass of: heteroarene
subclass of: polypyrrole
textual definition: A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.
imported from: mondo.owl
has_exact_synonym: tetrapyrrole
has_exact_synonym: tetrapyrroles
has_related_synonym: a tetrapyrrole

micronutrient
type: Class
subclass of: nutrient
textual definition: Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions.
imported from: mondo.owl
has_related_synonym: micronutrients
has_related_synonym: trace elements

transition element atom
type: Class
subclass of: metal atom
textual definition: An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell.
imported from: mondo.owl
has_exact_synonym: transition element
has_related_synonym: Uebergangselement
has_related_synonym: Uebergangsmetalle
has_related_synonym: metal de transicion
has_related_synonym: metal de transition
has_related_synonym: metales de transicion
has_related_synonym: metaux de transition
has_related_synonym: transition element
has_related_synonym: transition elements
has_related_synonym: transition metal
has_related_synonym: transition metals

organic heterobicyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: heterobicyclic compound
subclass of: organic heteropolycyclic compound
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: heterobicyclic compounds
has_related_synonym: organic heterobicyclic compounds
id: CHEBI:27171
in subset: 3 STAR

univalent carboacyl group
type: Class
subclass of: carboacyl group
textual definition: A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: univalent acyl group
has_related_synonym: univalent carboacyl groups
has_related_synonym: univalent carboxylic acyl groups
id: CHEBI:27207
in subset: 3 STAR

water-soluble vitamin
type: Class
subclass of: vitamin
imported from: mondo.owl
has_related_synonym: wasserloesliche Vitamine
has_related_synonym: water-soluble vitamins

zwitterion
type: Class
subclass of: dipolar compound
textual definition: A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer).
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: zwitterion
has_exact_synonym: zwitterions
has_related_synonym: compose zwitterionique
has_related_synonym: compuestos zwitterionicos
has_related_synonym: zwitteriones
has_related_synonym: zwitterionic compounds
id: CHEBI:27369
in subset: 3 STAR

carbon atom
type: Class
subclass of: nonmetal atom
subclass of: carbon group element atom
subclass of: Restriction
  on property: has role
  some values from: macronutrient
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:23009
has_alternative_id: CHEBI:3399
database_cross_reference: KEGG:C06265
database_cross_reference: WebElements:C
has_exact_synonym: carbon
has_related_synonym: 6C
has_related_synonym: C
has_related_synonym: Carbon
has_related_synonym: Kohlenstoff
has_related_synonym: carbon
has_related_synonym: carbone
has_related_synonym: carbonium
has_related_synonym: carbono
id: CHEBI:27594
in subset: 3 STAR

cobalt atom
type: Class
subclass of: cobalt group element atom
subclass of: metal allergen
subclass of: Restriction
  on property: has role
  some values from: micronutrient
textual definition: A cobalt group element atom that has atomic number 27.
imported from: mondo.owl
has_exact_synonym: cobalt
has_related_synonym: 27Co
has_related_synonym: Co
has_related_synonym: Cobalt
has_related_synonym: Kobalt
has_related_synonym: cobalt
has_related_synonym: cobalto
has_related_synonym: cobaltum

tetracycline
type: Class
subclass of: tertiary alpha-hydroxy ketone
subclass of: tetracyclines
subclass of: Restriction
  on property: has role
  some values from: antimicrobial agent
subclass of: Restriction
  on property: has role
  some values from: antiprotozoal drug
subclass of: Restriction
  on property: has role
  some values from: antibacterial drug
subclass of: Restriction
  on property: has role
  some values from: protein synthesis inhibitor
subclass of: Restriction
  on property: has role
  some values from: Escherichia coli metabolite
subclass of: Restriction
  on property: is conjugate acid of
  some values from: tetracycline(1-)
subclass of: Restriction
  on property: is conjugate acid of
  some values from: tetracycline zwitterion
textual definition: A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.
imported from: mondo.owl
has_exact_synonym: (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
has_exact_synonym: TETRACYCLINE
has_exact_synonym: Tetracycline
has_exact_synonym: tetracycline
has_related_synonym: (4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
has_related_synonym: Abramycin
has_related_synonym: Achromycin
has_related_synonym: Anhydrotetracycline
has_related_synonym: Deschlorobiomycin
has_related_synonym: Liquamycin
has_related_synonym: Tetracyclin
has_related_synonym: Tetrazyklin
has_related_synonym: Tsiklomitsin
has_related_synonym: tetracycline
has_related_synonym: tetracyclinum

beta-lactam antibiotic
type: Class
subclass of: organonitrogen heterocyclic antibiotic
subclass of: beta-lactam
textual definition: An organonitrogen heterocyclic antibiotic that contains a beta-lactam ring.
imported from: chebi.owl
imported from: dron.owl
has_alternative_id: CHEBI:10427
has_alternative_id: CHEBI:22844
database_cross_reference: KEGG:C03438
database_cross_reference: PMID:19254642
database_cross_reference: PMID:22594007
database_cross_reference: Wikipedia:Beta-lactam_antibiotic
has_obo_namespace: chebi_ontology
has_related_synonym: beta-Lactam antibiotics
has_related_synonym: beta-lactam antibiotics
id: CHEBI:27933
in subset: 3 STAR

carbamic acid
type: Class
subclass of: organonitrogen compound
subclass of: carbon oxoacid
subclass of: one-carbon compound
subclass of: Restriction
  on property: has role
  some values from: Escherichia coli metabolite
subclass of: Restriction
  on property: is conjugate acid of
  some values from: carbamate
textual definition: A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:22504
has_alternative_id: CHEBI:23002
has_alternative_id: CHEBI:3386
has_alternative_id: CHEBI:44573
database_cross_reference: DrugBank:DB04261
database_cross_reference: KEGG:C01563
database_cross_reference: PDBeChem:OUT
database_cross_reference: Wikipedia:Carbamic_acid
has_exact_synonym: CARBAMIC ACID
has_exact_synonym: Carbamic acid
has_exact_synonym: carbamic acid
has_related_synonym: Aminoameisensaeure
has_related_synonym: Aminoformic acid
has_related_synonym: Carbamate
has_related_synonym: Carbamidsaeure
id: CHEBI:28616
in subset: 3 STAR

ammonium
type: Class
subclass of: nitrogen hydride
subclass of: onium cation
subclass of: monovalent inorganic cation
subclass of: Restriction
  on property: has role
  some values from: cofactor
subclass of: Restriction
  on property: has role
  some values from: Saccharomyces cerevisiae metabolite
subclass of: Restriction
  on property: has role
  some values from: Escherichia coli metabolite
subclass of: Restriction
  on property: has role
  some values from: human metabolite
subclass of: Restriction
  on property: is conjugate acid of
  some values from: ammonia
textual definition: An onium cation obtained by protonation of ammonia.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:22534
has_alternative_id: CHEBI:49783
has_alternative_id: CHEBI:7435
database_cross_reference: KEGG:C01342
database_cross_reference: MetaCyc:AMMONIUM
database_cross_reference: MolBase:929
database_cross_reference: PDBeChem:NH4
database_cross_reference: Wikipedia:Ammonium
has_exact_synonym: ammonium
has_exact_synonym: azanium
has_related_synonym: Ammonium(1+)
has_related_synonym: NH4(+)
has_related_synonym: NH4+
has_related_synonym: [NH4](+)
has_related_synonym: ammonium cation
has_related_synonym: ammonium ion
id: CHEBI:28938
in subset: 3 STAR

carboxylic acid anion
type: Class
subclass of: organic anion
subclass of: oxoanion
subclass of: Restriction
  on property: is conjugate base of
  some values from: carboxylic acid
textual definition: The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:13626
has_alternative_id: CHEBI:13945
has_alternative_id: CHEBI:23026
has_alternative_id: CHEBI:58657
has_related_synonym: a carboxylate
has_related_synonym: carboxylic acid anions
has_related_synonym: carboxylic anions
id: CHEBI:29067
in subset: 3 STAR

azanide
type: Class
subclass of: nitrogen hydride
subclass of: monovalent inorganic anion
subclass of: Restriction
  on property: is conjugate acid of
  some values from: hydridonitrate(2-)
subclass of: Restriction
  on property: is conjugate base of
  some values from: ammonia
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: amide
has_exact_synonym: azanide
has_exact_synonym: dihydridonitrate(1-)
has_related_synonym: NH2(-)
id: CHEBI:29337
in subset: 3 STAR

hydridonitrate(2-)
type: Class
subclass of: nitrogen hydride
subclass of: divalent inorganic anion
subclass of: Restriction
  on property: is conjugate base of
  some values from: azanide
textual definition: A divalent inorganic anion resulting from the removal of two protons from ammonia.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: azanediide
has_exact_synonym: hydridonitrate(2-)
has_related_synonym: NH(2-)
has_related_synonym: imide
id: CHEBI:29340
in subset: 3 STAR

cobalamin
type: Class
subclass of: cobalamins
subclass of: Restriction
  on property: has role
  some values from: cofactor
subclass of: Restriction
  on property: has role
  some values from: prosthetic group
subclass of: Restriction
  on property: has role
  some values from: B vitamin
textual definition: A cobalt-corrinoid hexaamide that is cobalamin with the oxidation state of the central cobalt atom unspecified.
imported from: mondo.owl
has_exact_synonym: COBALAMIN
has_exact_synonym: Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-cobamide
has_exact_synonym: cobalamin

heme
type: Class
subclass of: metalloporphyrin
subclass of: iron coordination entity
subclass of: Restriction
  on property: has role
  some values from: metabolite
subclass of: Restriction
  on property: has role
  some values from: prosthetic group
textual definition: A heme is any tetrapyrrolic chelate of iron.
imported from: mondo.owl
has_exact_synonym: heme
has_exact_synonym: hemes
has_related_synonym: Haem
has_related_synonym: haem
has_related_synonym: haeme
has_related_synonym: hem
has_related_synonym: hemos

alcohol
type: Class
subclass of: organic hydroxy compound
textual definition: A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom.
imported from: mondo.owl
has_exact_synonym: Alcohol
has_exact_synonym: alcohols
has_related_synonym: an alcohol

tetracene
type: Class
subclass of: acene
subclass of: tetracenes
textual definition: An acene that consists of four ortho-fused benzene rings in a rectilinear arrangement.
imported from: mondo.owl
has_exact_synonym: tetracene
has_related_synonym: 2,3-benzanthracene
has_related_synonym: benz[b]anthracene
has_related_synonym: naphthacene

amide
type: Class
subclass of: nitrogen molecular entity
textual definition: An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:22473
has_alternative_id: CHEBI:2633
database_cross_reference: KEGG COMPOUND:C00241
database_cross_reference: KEGG:C00241
has_exact_synonym: Amide
has_exact_synonym: amides
has_obo_namespace: chebi_ontology
id: CHEBI:32988
in subset: 3 STAR

vitamin
type: Class
subclass of: micronutrient
subclass of: biochemical role
textual definition: A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term "vitamines" (from vita + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines.
imported from: mondo.owl
has_exact_synonym: Vitamin
has_related_synonym: vitamina
has_related_synonym: vitaminas
has_related_synonym: vitamine
has_related_synonym: vitamines
has_related_synonym: vitamins
has_related_synonym: vitaminum

application
type: Class
subclass of: role
textual definition: Intended use of the molecular entity or part thereof by humans.
imported from: hp.owl
imported from: mondo.owl
id: CHEBI:33232
in subset: 3 STAR

fundamental particle
type: Class
subclass of: subatomic particle
textual definition: A particle not known to have substructure.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: elementary particle
has_related_synonym: elementary particles
id: CHEBI:33233
in subset: 3 STAR

coordination entity
type: Class
subclass of: heteroatomic molecular entity
textual definition: An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands).
imported from: mondo.owl
has_exact_synonym: coordination entities
has_exact_synonym: coordination entity
has_related_synonym: coordination compounds

inorganic hydride
type: Class
subclass of: inorganic molecular entity
subclass of: hydrides
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: inorganic hydrides
id: CHEBI:33242
in subset: 3 STAR

organic fundamental parent
type: Class
subclass of: organic hydride
subclass of: organic molecular entity
textual definition: An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system.
imported from: mondo.owl
has_related_synonym: organic fundamental parents
has_related_synonym: organic parent hydrides

inorganic group
type: Class
subclass of: group
textual definition: Any substituent group which does not contain carbon.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: inorganic groups
id: CHEBI:33246
in subset: 3 STAR

organic group
type: Class
subclass of: molecular entity
subclass of: group
subclass of: Restriction
  on property: is substituent group from
  some values from: organic molecular entity
textual definition: Any substituent group or skeleton containing carbon.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: organic groups
id: CHEBI:33247
in subset: 3 STAR

organyl group
type: Class
subclass of: organic univalent group
textual definition: Any organic substituent group, regardless of functional type, having one free valence at a carbon atom.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: organyl group
has_exact_synonym: organyl groups
has_related_synonym: groupe organyle
has_related_synonym: grupo organilo
has_related_synonym: grupos organilo
id: CHEBI:33249
in subset: 3 STAR

atom
type: Class
subclass of: material entity
subclass of: chemical entity
subclass of: Restriction
  on property: has part
  some values from: electron
subclass of: Restriction
  on property: has part
  some values from: atomic nucleus
editor preferred label: atom
textual definition: A chemical entity constituting the smallest component of an element having the chemical properties of the element.
imported from: chebi.owl
imported from: hp.owl
imported from: mondo.owl
imported from: obi.owl
has_alternative_id: CHEBI:22671
has_alternative_id: CHEBI:23907
has_exact_synonym: atom
has_related_synonym: atome
has_related_synonym: atomo
has_related_synonym: atoms
has_related_synonym: atomus
has_related_synonym: element
has_related_synonym: elements
id: CHEBI:33250
in subset: 3 STAR

atomic nucleus
type: Class
subclass of: nuclear particle
subclass of: Restriction
  on property: has part
  some values from: nucleon
textual definition: A nucleus is the positively charged central portion of an atom, excluding the orbital electrons.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: nucleus
has_related_synonym: Atomkern
has_related_synonym: Kern
has_related_synonym: noyau
has_related_synonym: noyau atomique
has_related_synonym: nuclei
has_related_synonym: nucleo
has_related_synonym: nucleo atomico
has_related_synonym: nucleus atomi
id: CHEBI:33252
in subset: 3 STAR

nucleon
type: Class
subclass of: baryon
subclass of: nuclear particle
textual definition: Heavy nuclear particle: proton or neutron.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: nucleon
has_related_synonym: Nukleon
has_related_synonym: Nukleonen
has_related_synonym: nucleons
id: CHEBI:33253
in subset: 3 STAR

primary amide
type: Class
subclass of: amide
textual definition: A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: primary amide
has_exact_synonym: primary amides
id: CHEBI:33256
in subset: 3 STAR

organosulfur compound
type: Class
subclass of: sulfur molecular entity
subclass of: chalcogen molecular entity
subclass of: organochalcogen compound
textual definition: An organosulfur compound is a compound containing at least one carbon-sulfur bond.
imported from: chebi.owl
imported from: dron.owl
has_alternative_id: CHEBI:23010
has_alternative_id: CHEBI:25714
database_cross_reference: Wikipedia:Organosulfur_compounds
has_exact_synonym: organosulfur compound
has_obo_namespace: chebi_ontology
has_related_synonym: organosulfur compounds
id: CHEBI:33261
in subset: 3 STAR

polyatomic anion
type: Class
subclass of: anion
subclass of: polyatomic ion
textual definition: An anion consisting of more than one atom.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: polyatomic anions
id: CHEBI:33273
in subset: 3 STAR

molecular messenger
type: Class
subclass of: biological role
imported from: mondo.owl
has_related_synonym: chemical messenger

antimicrobial agent
type: Class
subclass of: biological role
textual definition: A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
imported from: mondo.owl
has_related_synonym: Antibiotika
has_related_synonym: Antibiotikum
has_related_synonym: antibiotic
has_related_synonym: antibiotics
has_related_synonym: antibiotique
has_related_synonym: antimicrobial
has_related_synonym: antimicrobial agents
has_related_synonym: antimicrobials
has_related_synonym: microbicide
has_related_synonym: microbicides

antibacterial agent
type: Class
subclass of: antimicrobial agent
textual definition: A substance (or active part thereof) that kills or slows the growth of bacteria.
imported from: mondo.owl
has_related_synonym: antibacterial agents
has_related_synonym: antibacterials
has_related_synonym: bactericide
has_related_synonym: bactericides

nutrient
type: Class
subclass of: food component
textual definition: A nutrient is a food component that an organism uses to survive and grow.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: nutrients
id: CHEBI:33284
in subset: 3 STAR

heteroorganic entity
type: Class
subclass of: organic molecular entity
textual definition: A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms.
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: chebi_ontology
has_related_synonym: heteroorganic entities
has_related_synonym: organoelement compounds
id: CHEBI:33285
in subset: 3 STAR

food
type: Class
subclass of: physiological role
subclass of: Restriction
  on property: has part
  some values from: food component
textual definition: A physiological role played by any substance of either plant, animal or artificial origin which contains essential body nutrients that can be ingested by an organism to provide energy, promote growth, and maintain the processes of life.
textual definition: Any material that can be ingested by an organism.
imported from: chebi.owl
imported from: mondo.owl
has_related_synonym: food material
has_related_synonym: food materials
has_related_synonym: food role
has_related_synonym: foods
has_related_synonym: foodstuff
has_related_synonym: foodstuffs

pnictogen
type: Class
subclass of: p-block element atom
textual definition: Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: pnictogens
has_related_synonym: group 15 elements
has_related_synonym: group V elements
has_related_synonym: nitrogenoideos
has_related_synonym: nitrogenoides
has_related_synonym: pnictogene
has_related_synonym: pnictogenes
id: CHEBI:33300
in subset: 3 STAR

pnictogen molecular entity
type: Class
subclass of: p-block molecular entity
subclass of: Restriction
  on property: has part
  some values from: pnictogen
textual definition: A p-block molecular entity containing any pnictogen.
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: pnictogen molecular entity
has_related_synonym: pnictogen molecular entities
id: CHEBI:33302
in subset: 3 STAR

chalcogen
type: Class
subclass of: p-block element atom
textual definition: Any p-block element belonging to the group 16 family of the periodic table.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: chalcogen
has_exact_synonym: chalcogens
has_related_synonym: Chalkogen
has_related_synonym: Chalkogene
has_related_synonym: anfigeno
has_related_synonym: anfigenos
has_related_synonym: calcogeno
has_related_synonym: calcogenos
has_related_synonym: chalcogene
has_related_synonym: chalcogenes
has_related_synonym: group 16 elements
has_related_synonym: group VI elements
id: CHEBI:33303
in subset: 3 STAR

chalcogen molecular entity
type: Class
subclass of: p-block molecular entity
subclass of: Restriction
  on property: has part
  some values from: chalcogen
textual definition: Any p-block molecular entity containing a chalcogen.
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: chalcogen molecular entity
has_obo_namespace: chebi_ontology
has_related_synonym: chalcogen compounds
has_related_synonym: chalcogen molecular entities
id: CHEBI:33304
in subset: 3 STAR

carbon group element atom
type: Class
subclass of: p-block element atom
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: group 14 elements
has_related_synonym: carbon group element
has_related_synonym: carbon group elements
has_related_synonym: carbonoides
has_related_synonym: cristallogene
has_related_synonym: cristallogenes
has_related_synonym: group IV elements
id: CHEBI:33306
in subset: 3 STAR

main group element atom
type: Class
subclass of: atom
textual definition: An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: main group elements
has_related_synonym: Hauptgruppenelement
has_related_synonym: Hauptgruppenelemente
has_related_synonym: main group element
id: CHEBI:33318
in subset: 3 STAR

iron group element atom
type: Class
subclass of: d-block element atom
imported from: mondo.owl
has_exact_synonym: group 8 elements
has_related_synonym: iron group element
has_related_synonym: iron group elements

cobalt group element atom
type: Class
subclass of: d-block element atom
imported from: mondo.owl
has_exact_synonym: group 9 elements
has_related_synonym: cobalt group element
has_related_synonym: cobalt group elements

transition element molecular entity
type: Class
subclass of: molecular entity
subclass of: Restriction
  on property: has part
  some values from: transition element atom
textual definition: A molecular entity containing one or more atoms of a transition element.
imported from: mondo.owl
has_related_synonym: transition element molecular entities
has_related_synonym: transition metal molecular entity

metal atom
type: Class
subclass of: atom
textual definition: An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:25217
has_alternative_id: CHEBI:6788
database_cross_reference: KEGG:C00050
database_cross_reference: Wikipedia:Metal
has_related_synonym: elemental metal
has_related_synonym: elemental metals
has_related_synonym: metal element
has_related_synonym: metal elements
has_related_synonym: metals
id: CHEBI:33521
in subset: 3 STAR

alpha-amino-acid anion
type: Class
subclass of: amino-acid anion
subclass of: Restriction
  on property: is conjugate base of
  some values from: alpha-amino acid
textual definition: An amino-acid anion obtained by deprotonation of any alpha-amino acid.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: alpha-amino-acid anion
has_related_synonym: alpha-amino acid anions
has_related_synonym: alpha-amino-acid anions
id: CHEBI:33558
in subset: 3 STAR

s-block element atom
type: Class
subclass of: atom
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: s-block element
has_related_synonym: s-block elements
id: CHEBI:33559
in subset: 3 STAR

p-block element atom
type: Class
subclass of: main group element atom
textual definition: Any main group element atom belonging to the p-block of the periodic table.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: p-block element
has_related_synonym: p-block elements
id: CHEBI:33560
in subset: 3 STAR

d-block element atom
type: Class
subclass of: transition element atom
imported from: mondo.owl
has_related_synonym: d-block element
has_related_synonym: d-block elements

carboxylic acid
type: Class
subclass of: oxoacid
subclass of: carbon oxoacid
subclass of: carbonyl compound
subclass of: organic molecular entity
subclass of: organic acid
subclass of: Restriction
  on property: has part
  some values from: carboxy group
subclass of: Restriction
  on property: is conjugate acid of
  some values from: carboxylic acid anion
textual definition: A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
textual definition: An oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
charge: 0
formula: CHO2R
mass: 45.01740
monoisotopicmass: 44.99765
smiles: OC([*])=O
has_alternative_id: CHEBI:13428
has_alternative_id: CHEBI:13627
has_alternative_id: CHEBI:23027
database_cross_reference: CiteXplore:17147560
database_cross_reference: CiteXplore:18433345
database_cross_reference: PMID:17147560
database_cross_reference: PMID:18433345
database_cross_reference: Wikipedia:Carboxylic_acid
has_exact_synonym: carboxylic acid
has_exact_synonym: carboxylic acids
has_obo_namespace: chebi_ontology
has_related_synonym: CHO2R
has_related_synonym: Carbonsaeure
has_related_synonym: Carbonsaeuren
has_related_synonym: Karbonsaeure
has_related_synonym: OC([*])=O
has_related_synonym: RC(=O)OH
has_related_synonym: acide carboxylique
has_related_synonym: acides carboxyliques
has_related_synonym: acido carboxilico
has_related_synonym: acidos carboxilicos
id: CHEBI:33575
in subset: 3 STAR

main group molecular entity
type: Class
subclass of: molecular entity
subclass of: Restriction
  on property: has part
  some values from: main group element atom
textual definition: A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table.
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: chebi_ontology
has_related_synonym: main group compounds
has_related_synonym: main group molecular entities
id: CHEBI:33579
in subset: 3 STAR

carbon group molecular entity
type: Class
subclass of: p-block molecular entity
subclass of: Restriction
  on property: has part
  some values from: carbon group element atom
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: carbon group molecular entity
has_related_synonym: carbon group molecular entities
id: CHEBI:33582
in subset: 3 STAR

cyclic compound
type: Class
subclass of: molecule
subclass of: polyatomic entity
textual definition: Any molecule that consists of a series of atoms joined together to form a ring.
imported from: chebi.owl
imported from: dron.owl
imported from: mondo.owl
database_cross_reference: Wikipedia:Cyclic_compound
has_obo_namespace: chebi_ontology
has_related_synonym: cyclic compounds
id: CHEBI:33595
in subset: 3 STAR

homocyclic compound
type: Class
subclass of: cyclic compound
textual definition: A cyclic compound having as ring members atoms of the same element only.
imported from: mondo.owl
has_exact_synonym: homocyclic compound
has_exact_synonym: homocyclic compounds
has_related_synonym: isocyclic compounds

carbocyclic compound
type: Class
subclass of: homocyclic compound
subclass of: organic cyclic compound
textual definition: A homocyclic compound in which all of the ring members are carbon atoms.
imported from: mondo.owl
has_exact_synonym: carbocyclic compound
has_exact_synonym: carbocyclic compounds
has_related_synonym: carbocycle

hydrogen molecular entity
type: Class
subclass of: s-block molecular entity
subclass of: Restriction
  on property: has part
  some values from: hydrogen atom
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: hydrogen compounds
has_related_synonym: hydrogen molecular entities
id: CHEBI:33608
in subset: 3 STAR

polycyclic compound
type: Class
subclass of: cyclic compound
imported from: mondo.owl
has_related_synonym: polycyclic compounds

bicyclic compound
type: Class
subclass of: cyclic compound
textual definition: A molecule that features two fused rings.
imported from: dron.owl
has_related_synonym: bicyclic compounds
id: CHEBI:33636

ortho-fused compound
type: Class
subclass of: fused compound
textual definition: A polycyclic compound in which two rings have two, and only two, atoms in common. Such compounds have n common faces and 2n common atoms.
imported from: mondo.owl
has_exact_synonym: ortho-fused polycyclic compounds
has_related_synonym: ortho-fused compounds

aromatic compound
type: Class
subclass of: cyclic compound
textual definition: A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.
imported from: mondo.owl
has_exact_synonym: aromatic compounds
has_exact_synonym: aromatic molecular entity
has_related_synonym: aromatics
has_related_synonym: aromatische Verbindungen

arene
type: Class
subclass of: organic aromatic compound
subclass of: cyclic hydrocarbon
textual definition: Any monocyclic or polycyclic aromatic hydrocarbon.
imported from: mondo.owl
has_exact_synonym: arene
has_exact_synonym: arenes
has_related_synonym: aromatic hydrocarbons

organic aromatic compound
type: Class
subclass of: aromatic compound
subclass of: organic cyclic compound
imported from: mondo.owl
has_related_synonym: organic aromatic compounds

cyclic hydrocarbon
type: Class
subclass of: hydrocarbon
subclass of: carbocyclic compound
imported from: mondo.owl
has_exact_synonym: cyclic hydrocarbon
has_related_synonym: cyclic hydrocarbons

polycyclic hydrocarbon
type: Class
subclass of: cyclic hydrocarbon
subclass of: carbopolycyclic compound
imported from: mondo.owl
has_exact_synonym: polycyclic hydrocarbon
has_exact_synonym: polycyclic hydrocarbons

heteropolycyclic compound
type: Class
subclass of: cyclic compound
subclass of: heterocyclic compound
textual definition: A polycyclic compound in which at least one of the rings contains at least one non-carbon atom.
imported from: chebi.owl
has_exact_synonym: heteropolycyclic compounds
has_obo_namespace: chebi_ontology
has_related_synonym: polyheterocyclic compounds
id: CHEBI:33671
in subset: 3 STAR

heterobicyclic compound
type: Class
subclass of: cyclic compound
subclass of: bicyclic compound
subclass of: heterocyclic compound
textual definition: A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom.
imported from: chebi.owl
imported from: dron.owl
has_exact_synonym: heterobicyclic compounds
has_obo_namespace: chebi_ontology
id: CHEBI:33672
in subset: 3 STAR

s-block molecular entity
type: Class
subclass of: main group molecular entity
subclass of: Restriction
  on property: has part
  some values from: s-block element atom
textual definition: An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element.
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: s-block molecular entity
has_related_synonym: s-block compounds
has_related_synonym: s-block molecular entities
id: CHEBI:33674
in subset: 3 STAR

p-block molecular entity
type: Class
subclass of: main group molecular entity
subclass of: Restriction
  on property: has part
  some values from: p-block element atom
textual definition: A main group molecular entity that contains one or more atoms of a p-block element.
textual definition: A p-block molecular entity is a molecular entity containing one or more atoms of a p-block element.
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: chebi_ontology
has_related_synonym: p-block compounds
has_related_synonym: p-block molecular entities
has_related_synonym: p-block molecular entitiy
id: CHEBI:33675
in subset: 3 STAR

d-block molecular entity
type: Class
subclass of: transition element molecular entity
subclass of: Restriction
  on property: has part
  some values from: d-block element atom
textual definition: A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element.
imported from: mondo.owl
has_exact_synonym: d-block molecular entity
has_related_synonym: d-block compounds
has_related_synonym: d-block molecular entities

hydrides
type: Class
subclass of: hydrogen molecular entity
subclass of: heteroatomic molecular entity
textual definition: Hydrides are chemical compounds of hydrogen with other chemical elements.
imported from: hp.owl
imported from: mondo.owl
id: CHEBI:33692
in subset: 3 STAR

biomacromolecule
type: Class
subclass of: macromolecule
subclass of: organic molecular entity
textual definition: A macromolecule formed by a living organism.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: biopolymer
has_related_synonym: Biopolymere
has_related_synonym: biomacromolecules
has_related_synonym: biopolymers
id: CHEBI:33694
in subset: 3 STAR

information biomacromolecule
type: Class
subclass of: biomacromolecule
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: genetically encoded biomacromolecules
has_related_synonym: genetically encoded biopolymers
has_related_synonym: information biomacromolecules
has_related_synonym: information biopolymers
has_related_synonym: information macromolecule
has_related_synonym: information macromolecules
id: CHEBI:33695
in subset: 3 STAR

nucleic acid
type: Class
subclass of: macromolecule
editor preferred label: nucleic acid
textual definition: A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.
imported from: chebi.owl
imported from: obi.owl

proteinogenic amino-acid residue
type: Class
subclass of: alpha-amino-acid residue
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: canonical amino-acid residue
has_related_synonym: canonical amino-acid residues
has_related_synonym: common amino acid residues
has_related_synonym: proteinogenic amino-acid residues
has_related_synonym: standard amino acid residues
has_related_synonym: standard amino-acid residues
id: CHEBI:33700
in subset: 3 STAR

alpha-amino acid
type: Class
subclass of: amino acid
subclass of: Restriction
  on property: is conjugate acid of
  some values from: alpha-amino-acid anion
subclass of: Restriction
  on property: is tautomer of
  some values from: alpha-amino acid zwitterion
textual definition: An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:10208
has_alternative_id: CHEBI:13779
has_alternative_id: CHEBI:22442
has_alternative_id: CHEBI:2642
database_cross_reference: KEGG:C00045
database_cross_reference: KEGG:C05167
has_exact_synonym: alpha-amino acid
has_related_synonym: Amino acid
has_related_synonym: Amino acids
has_related_synonym: alpha-amino acids
has_related_synonym: alpha-amino carboxylic acids
id: CHEBI:33704
in subset: 3 STAR

amino-acid residue
type: Class
subclass of: molecular entity
subclass of: organic group
subclass of: Restriction
  on property: is substituent group from
  some values from: amino acid
textual definition: When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: pr.owl
has_exact_synonym: amino acid residue
has_exact_synonym: amino-acid residue
has_narrow_synonym: protein residue
has_obo_namespace: chebi_ontology
has_related_synonym: amino acid residue
has_related_synonym: amino-acid residues
id: CHEBI:33708
in subset: 3 STAR

amino acid
type: Class
subclass of: carboxylic acid
subclass of: organic amino compound
subclass of: Restriction
  on property: is conjugate acid of
  some values from: amino-acid anion
textual definition: A carboxylic acid containing one or more amino groups.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:13815
has_alternative_id: CHEBI:22477
database_cross_reference: Wikipedia:Amino_acid
has_related_synonym: Aminocarbonsaeure
has_related_synonym: Aminokarbonsaeure
has_related_synonym: Aminosaeure
has_related_synonym: amino acids
id: CHEBI:33709
in subset: 3 STAR

alpha-amino-acid residue
type: Class
subclass of: amino-acid residue
subclass of: Restriction
  on property: is substituent group from
  some values from: alpha-amino acid
textual definition: An amino-acid residue derived from an alpha-amino acid.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: alpha-amino-acid residues
has_related_synonym: an alpha-amino acid residue
id: CHEBI:33710
in subset: 3 STAR

carbohydrate acid
type: Class
subclass of: carbohydrate
subclass of: carboxylic acid
subclass of: Restriction
  on property: is conjugate acid of
  some values from: carbohydrate acid anion
imported from: hp.owl
has_exact_synonym: carbohydrate acid
has_related_synonym: carbohydrate acids
id: CHEBI:33720
in subset: 3 STAR

carbohydrate acid anion
type: Class
subclass of: carboxylic acid anion
subclass of: Restriction
  on property: is conjugate base of
  some values from: carbohydrate acid
imported from: hp.owl
has_exact_synonym: carbohydrate acid anion
has_related_synonym: carbohydrate acid anions
id: CHEBI:33721
in subset: 3 STAR

iron group molecular entity
type: Class
subclass of: d-block molecular entity
subclass of: Restriction
  on property: has part
  some values from: iron group element atom
imported from: mondo.owl
has_exact_synonym: iron group molecular entity
has_related_synonym: iron group molecular entities

cobalt group molecular entity
type: Class
subclass of: d-block molecular entity
subclass of: Restriction
  on property: has part
  some values from: cobalt group element atom
imported from: mondo.owl
has_exact_synonym: cobalt group molecular entity
has_related_synonym: cobalt group molecular entities

organic hydroxy compound
type: Class
subclass of: hydroxides
subclass of: organic molecular entity
textual definition: An organic compound having at least one hydroxy group attached to a carbon atom.
imported from: mondo.owl
has_exact_synonym: hydroxy compounds
has_related_synonym: organic alcohol
has_related_synonym: organic hydroxy compounds

organic cyclic compound
type: Class
subclass of: cyclic compound
subclass of: organic molecular entity
subclass of: organic molecule
textual definition: Any organic molecule that consists of atoms connected in the form of a ring.
imported from: chebi.owl
imported from: dron.owl
imported from: mondo.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic cyclic compounds
id: CHEBI:33832
in subset: 3 STAR

heteroarene
type: Class
subclass of: organic heterocyclic compound
subclass of: organic aromatic compound
textual definition: A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).
imported from: mondo.owl
has_exact_synonym: heteroarenes
has_related_synonym: hetarenes

benzenoid aromatic compound
type: Class
subclass of: carbocyclic compound
subclass of: organic aromatic compound
imported from: mondo.owl
has_related_synonym: benzenoid aromatic compounds
has_related_synonym: benzenoid compound

conjugated protein
type: Class
subclass of: protein
textual definition: Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion.
imported from: mondo.owl
has_exact_synonym: conjugated proteins
has_related_synonym: complex protein

macromolecule
type: Class
subclass of: molecular entity
subclass of: polyatomic entity
editor preferred label: macromolecule
textual definition: A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
alternative term: polymer
imported from: chebi.owl
imported from: hp.owl
imported from: mondo.owl
imported from: obi.owl
database_cross_reference: Wikipedia:Macromolecule
has_exact_synonym: macromolecule
has_related_synonym: macromolecules
has_related_synonym: polymer
has_related_synonym: polymer molecule
has_related_synonym: polymers
id: CHEBI:33839
in subset: 3 STAR

polycyclic arene
type: Class
subclass of: arene
subclass of: polycyclic hydrocarbon
subclass of: Restriction
  on property: has role
  some values from: endocrine disruptor
subclass of: Restriction
  on property: has role
  some values from: carcinogenic agent
textual definition: A polycyclic aromatic hydrocarbon.
imported from: mondo.owl
has_related_synonym: PAH
has_related_synonym: PAHs
has_related_synonym: polycyclic arenes
has_related_synonym: polycyclic aromatic hydrocarbons

transition element coordination entity
type: Class
subclass of: coordination entity
subclass of: transition element molecular entity
imported from: mondo.owl
has_related_synonym: transition element coordination entities
has_related_synonym: transition metal coordination compounds
has_related_synonym: transition metal coordination entities

cobalt molecular entity
type: Class
subclass of: cobalt group molecular entity
subclass of: Restriction
  on property: has part
  some values from: cobalt atom
imported from: mondo.owl
has_exact_synonym: cobalt molecular entity
has_related_synonym: cobalt compounds
has_related_synonym: cobalt molecular entities

cobalt coordination entity
type: Class
subclass of: transition element coordination entity
subclass of: cobalt molecular entity
imported from: mondo.owl
has_exact_synonym: cobalt coordination entity
has_related_synonym: cobalt coordination compounds
has_related_synonym: cobalt coordination entities

iron coordination entity
type: Class
subclass of: iron molecular entity
subclass of: transition element coordination entity
imported from: mondo.owl
has_exact_synonym: iron coordination entity
has_related_synonym: iron coordination compounds
has_related_synonym: iron coordination entities

reagent
type: Class
subclass of: application
textual definition: A substance used in a chemical reaction to detect, measure, examine, or produce other substances.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: reagent
has_related_synonym: reactif
has_related_synonym: reactivo
has_related_synonym: reagents
id: CHEBI:33893
in subset: 3 STAR

cobalt corrinoid
type: Class
subclass of: cobalt coordination entity
subclass of: metallotetrapyrrole
subclass of: corrinoid
imported from: mondo.owl
has_related_synonym: cobalt corrinoids
has_related_synonym: cobalt-corrinoids

metallotetrapyrrole
type: Class
subclass of: cyclic tetrapyrrole
imported from: mondo.owl
has_related_synonym: metal-tetrapyrrole
has_related_synonym: metal-tetrapyrrole complex
has_related_synonym: metallotetrapyrroles

corrinoid
type: Class
subclass of: cyclic tetrapyrrole
subclass of: Restriction
  on property: has role
  some values from: cofactor
textual definition: A derivative of the corrin nucleus, which contains four reduced or partly reduced pyrrole rings joined in a macrocycle by three =C- groups and one direct carbon-carbon bond linking alpha positions.
imported from: mondo.owl
has_exact_synonym: Corrinoid
has_exact_synonym: corrinoid
has_exact_synonym: corrinoids
has_related_synonym: Corrinoid protein
has_related_synonym: Corrinoid protein Co+
has_related_synonym: Korrinoid
has_related_synonym: corrinoide
has_related_synonym: corrinoides

macronutrient
type: Class
subclass of: nutrient
textual definition: Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: macronutrients
id: CHEBI:33937
in subset: 3 STAR

nitrogen hydride
type: Class
subclass of: pnictogen hydride
subclass of: nitrogen molecular entity
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: nitrogen hydrides
id: CHEBI:35106
in subset: 3 STAR

azane
type: Class
subclass of: nitrogen hydride
textual definition: Saturated acyclic nitrogen hydrides having the general formula NnHn+2.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: azanes
id: CHEBI:35107
in subset: 3 STAR

metalloprotein
type: Class
subclass of: conjugated protein
imported from: mondo.owl
has_exact_synonym: metalloprotein
has_related_synonym: metalloproteine
has_related_synonym: metalloproteins

iron protein
type: Class
subclass of: metalloprotein
imported from: mondo.owl
has_exact_synonym: iron protein
has_related_synonym: iron proteins
has_related_synonym: iron-containing proteins

hemoprotein
type: Class
subclass of: iron protein
subclass of: Restriction
  on property: has part
  some values from: heme
textual definition: Conjugated proteins containing heme as the prosthetic group.
imported from: mondo.owl
has_exact_synonym: hemoprotein
has_related_synonym: Haemoprotein
has_related_synonym: Haemprotein
has_related_synonym: haem protein
has_related_synonym: haemoprotein
has_related_synonym: heme protein
has_related_synonym: hemeproteins
has_related_synonym: hemoproteins

hemoglobin
type: Class
subclass of: globin
imported from: mondo.owl
has_exact_synonym: hemoglobin
has_related_synonym: haemoglobin
has_related_synonym: vertebrate haemoglobin

inhibitor
type: Class
subclass of: biological role
textual definition: A substance that diminishes the rate of a chemical reaction.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: inhibitor
has_related_synonym: inhibidor
has_related_synonym: inhibiteur
has_related_synonym: inhibitors
id: CHEBI:35222
in subset: 3 STAR

amino acid zwitterion
type: Class
subclass of: zwitterion
textual definition: The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: amino acid zwitterion
id: CHEBI:35238
in subset: 3 STAR

fused compound
type: Class
subclass of: polycyclic compound
imported from: mondo.owl
has_related_synonym: fused compounds
has_related_synonym: fused polycyclic compounds
has_related_synonym: fused-ring polycyclic compound
has_related_synonym: fused-ring polycyclic compounds
has_related_synonym: polycyclic fused-ring compounds

carbopolycyclic compound
type: Class
subclass of: carbocyclic compound
subclass of: homopolycyclic compound
textual definition: A polyclic compound in which all of the ring members are carbon atoms.
imported from: mondo.owl
has_related_synonym: carbopolycyclic compounds

homopolycyclic compound
type: Class
subclass of: homocyclic compound
subclass of: polycyclic compound
imported from: mondo.owl
has_related_synonym: homopolycyclic compounds

ortho-fused polycyclic arene
type: Class
subclass of: polycyclic arene
subclass of: ortho-fused polycyclic hydrocarbon
imported from: mondo.owl
has_related_synonym: ortho-fused polycyclic arenes

acene
type: Class
subclass of: ortho-fused polycyclic arene
subclass of: acenes
textual definition: A polycyclic aromatic hydrocarbon consisting of fused benzene rings in a rectilinear arrangement.
imported from: mondo.owl
has_exact_synonym: acene
has_exact_synonym: acenes
has_related_synonym: Acen
has_related_synonym: Azen
has_related_synonym: polyacenes

steroid
type: Class
subclass of: lipid
subclass of: organic polycyclic compound
textual definition: Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene, so may be considered as triterpenoids.
imported from: mondo.owl
has_exact_synonym: Steroid
has_exact_synonym: steroids
has_related_synonym: a steroid

organonitrogen compound
type: Class
subclass of: heteroorganic entity
subclass of: nitrogen molecular entity
textual definition: Any heteroorganic entity containing at least one carbon-nitrogen bond.
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: organonitrogen compounds
has_obo_namespace: chebi_ontology
has_related_synonym: organonitrogens
id: CHEBI:35352
in subset: 3 STAR

oxoanion
type: Class
subclass of: oxide
subclass of: polyatomic anion
textual definition: An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:33274
has_alternative_id: CHEBI:33436
has_exact_synonym: oxoanion
has_related_synonym: oxoacid anions
has_related_synonym: oxoanions
id: CHEBI:35406
in subset: 3 STAR

ortho-fused polycyclic hydrocarbon
type: Class
subclass of: ortho-fused compound
imported from: mondo.owl
has_exact_synonym: ortho-fused polycyclic hydrocarbon
has_related_synonym: ortho-fused polycyclic hydrocarbons

antiinfective agent
type: Class
subclass of: drug
textual definition: A substance used in the prophylaxis or therapy of infectious diseases.
imported from: mondo.owl
has_related_synonym: anti-infective agents
has_related_synonym: anti-infective drugs
has_related_synonym: antiinfective agents
has_related_synonym: antiinfective drug

antiparasitic agent
type: Class
subclass of: antiinfective agent
textual definition: A substance used to treat or prevent parasitic infections.
imported from: mondo.owl
has_related_synonym: antiparasitic drugs
has_related_synonym: antiparasitics
has_related_synonym: parasiticides

carbon oxoacid
type: Class
subclass of: hydroxides
subclass of: oxoacid
subclass of: organooxygen compound
imported from: chebi.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: chebi_ontology
has_related_synonym: carbon oxoacids
has_related_synonym: oxoacids of carbon
id: CHEBI:35605
in subset: 3 STAR

beta-lactam
type: Class
subclass of: lactam
textual definition: A beta-lactam is a lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.
textual definition: A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.
imported from: chebi.owl
imported from: dron.owl
charge: 0
formula: C3H2NOR3
mass: 68.054
monoisotopicmass: 68.01364
smiles: C1(C(N(*)C1*)=O)*
has_alternative_id: CHEBI:10426
has_alternative_id: CHEBI:13203
has_alternative_id: CHEBI:22845
database_cross_reference: KEGG COMPOUND:C01866
database_cross_reference: KEGG:C01866
database_cross_reference: Wikipedia:Beta-lactam
has_exact_synonym: beta-Lactam
has_exact_synonym: beta-lactam
has_obo_namespace: chebi_ontology
has_related_synonym: a beta-lactam
has_related_synonym: beta-lactams
id: CHEBI:35627
in subset: 3 STAR

antiprotozoal drug
type: Class
subclass of: antiparasitic agent
subclass of: antimicrobial drug
textual definition: Any antimicrobial drug which is used to treat or prevent protozoal infections.
imported from: mondo.owl
has_related_synonym: antiprotozoal agent
has_related_synonym: antiprotozoal agents
has_related_synonym: antiprotozoal drugs

pnictogen hydride
type: Class
subclass of: inorganic hydride
subclass of: pnictogen molecular entity
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: pnictogen hydride
has_related_synonym: pnictogen hydrides
id: CHEBI:35881
in subset: 3 STAR

penams
type: Class
subclass of: organic heterobicyclic compound
subclass of: beta-lactam antibiotic
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
textual definition: Natural and synthetic antibiotics containing the 4-thia-1-azabicyclo[3.2.0]heptan-7-one structure, generally assumed to have the 5R configuration unless otherwise specified.
imported from: chebi.owl
imported from: dron.owl
has_exact_synonym: penams
has_obo_namespace: chebi_ontology
id: CHEBI:35992
in subset: 3 STAR

antimicrobial drug
type: Class
subclass of: antimicrobial agent
subclass of: antiinfective agent
textual definition: A drug used to treat or prevent microbial infections.
imported from: mondo.owl
has_related_synonym: antimicrobial drugs

antibacterial drug
type: Class
subclass of: antibacterial agent
subclass of: antimicrobial drug
textual definition: A drug used to treat or prevent bacterial infections.
imported from: mondo.owl
has_related_synonym: antibacterial drugs

protein
type: Class
equivalent class: PR_000000001
subclass of: information biomacromolecule
subclass of: PR_000000001
subclass of: Restriction
  on property: has part
  some values from: protein polypeptide chain
textual definition: A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:13677
has_alternative_id: CHEBI:14911
has_exact_synonym: proteins
id: CHEBI:36080
in subset: 3 STAR

cyclic tetrapyrrole
type: Class
subclass of: tetrapyrrole
subclass of: cyclic polypyrrole
imported from: mondo.owl
has_exact_synonym: macrocyclic tetrapyrroles
has_related_synonym: cyclic tetrapyrroles
has_related_synonym: macrocyclic tetrapyrrole

lepton
type: Class
subclass of: fundamental particle
subclass of: fermion
textual definition: Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin).
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: leptons
id: CHEBI:36338
in subset: 3 STAR

baryon
type: Class
subclass of: fermion
subclass of: hadron
textual definition: Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy).
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: baryons
id: CHEBI:36339
in subset: 3 STAR

fermion
type: Class
subclass of: subatomic particle
textual definition: Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: fermion
has_related_synonym: fermions
id: CHEBI:36340
in subset: 3 STAR

subatomic particle
type: Class
subclass of: material entity
textual definition: A particle smaller than an atom.
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: Wikipedia:Subatomic_particle
has_related_synonym: subatomic particles
id: CHEBI:36342
in subset: 3 STAR

composite particle
type: Class
subclass of: subatomic particle
textual definition: A subatomic particle known to have substructure (i.e. consisting of smaller particles).
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: composite particles
id: CHEBI:36343
in subset: 3 STAR

hadron
type: Class
subclass of: composite particle
textual definition: Hadron is a subatomic particle which experiences the strong force.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: hadrons
id: CHEBI:36344
in subset: 3 STAR

nuclear particle
type: Class
subclass of: subatomic particle
textual definition: A nucleus or any of its constituents in any of their energy states.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: nuclear particle
id: CHEBI:36347
in subset: 3 STAR

polyatomic entity
type: Class
subclass of: molecular entity
subclass of: Restriction
  on property: has part
  some values from: group
textual definition: Any molecular entity consisting of more than one atom.
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: chebi_ontology
has_related_synonym: polyatomic entities
id: CHEBI:36357
in subset: 3 STAR

polyatomic ion
type: Class
subclass of: ion
subclass of: polyatomic entity
textual definition: An ion consisting of more than one atom.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: polyatomic ions
id: CHEBI:36358
in subset: 3 STAR

pseudoketone
type: Class
subclass of: carbonyl compound
imported from: dron.owl
has_exact_synonym: pseudoketone
has_exact_synonym: pseudoketones
has_related_synonym: pseudoketones
id: CHEBI:36585

carbonyl compound
type: Class
subclass of: organic oxo compound
subclass of: organooxygen compound
subclass of: organic molecule
subclass of: Restriction
  on property: has part
  some values from: carbonyl group
textual definition: Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: carbonyl compounds
has_obo_namespace: chebi_ontology
id: CHEBI:36586
in subset: 3 STAR

organic oxo compound
type: Class
subclass of: organic molecular entity
subclass of: organic molecule
subclass of: Restriction
  on property: has part
  some values from: oxo group
textual definition: Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element.
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: oxo compounds
has_related_synonym: organic oxo compounds
id: CHEBI:36587
in subset: 3 STAR

cyclic pseudoketone
type: Class
subclass of: pseudoketone
textual definition: A cyclic compound in which a carbonyl group in a ring is bonded to one or two skeletal heteroatoms.
imported from: dron.owl
has_related_synonym: cyclic pseudoketones
id: CHEBI:36588

corticosteroid hormone
type: Class
subclass of: steroid hormone
subclass of: corticosteroid
textual definition: Any of a class of steroid hormones that are produced in the adrenal cortex.
imported from: mondo.owl
has_related_synonym: adrenal cortex hormones
has_related_synonym: corticosteroid hormones

inorganic ion
type: Class
subclass of: inorganic molecular entity
subclass of: ion
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: inorganic ions
id: CHEBI:36914
in subset: 3 STAR

inorganic cation
type: Class
subclass of: inorganic ion
subclass of: cation
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: inorganic cations
id: CHEBI:36915
in subset: 3 STAR

cation
type: Class
subclass of: ion
textual definition: A monoatomic or polyatomic species having one or more elementary charges of the proton.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:23058
has_alternative_id: CHEBI:3473
database_cross_reference: KEGG:C01373
has_exact_synonym: Cation
has_exact_synonym: cation
has_related_synonym: Kation
has_related_synonym: Kationen
has_related_synonym: cationes
has_related_synonym: cations
id: CHEBI:36916
in subset: 3 STAR

organochalcogen compound
type: Class
subclass of: heteroorganic entity
subclass of: chalcogen molecular entity
textual definition: An organochalcogen compound is a compound containing at least one carbon-chalcogen bond.
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: organochalcogen compound
has_obo_namespace: chebi_ontology
has_related_synonym: organochalcogen compounds
id: CHEBI:36962
in subset: 3 STAR

organooxygen compound
type: Class
subclass of: oxygen molecular entity
subclass of: organochalcogen compound
textual definition: An organochalcogen compound containing at least one carbon-oxygen bond.
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: CiteXplore:17586126
database_cross_reference: PMID:17586126
has_exact_synonym: organooxygen compound
has_obo_namespace: chebi_ontology
has_related_synonym: organooxygen compounds
id: CHEBI:36963
in subset: 3 STAR

amino-acid anion
type: Class
subclass of: carboxylic acid anion
subclass of: organonitrogen compound
subclass of: Restriction
  on property: is conjugate base of
  some values from: amino acid
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: amino-acid anion
has_related_synonym: amino acid anions
has_related_synonym: amino-acid anions
id: CHEBI:37022
in subset: 3 STAR

organic hydride
type: Class
subclass of: hydrides
imported from: mondo.owl
has_related_synonym: organic hydrides

mononuclear parent hydride
type: Class
subclass of: hydrides
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: mononuclear parent hydrides
has_related_synonym: mononuclear hydride
has_related_synonym: mononuclear hydrides
id: CHEBI:37176
in subset: 3 STAR

mucopolysaccharide
type: Class
subclass of: glycosaminoglycan
textual definition: Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid.
imported from: hp.owl
has_alternative_id: CHEBI:25425
has_alternative_id: CHEBI:7011
database_cross_reference: KEGG:C05114
has_exact_synonym: Mucopolysaccharide
has_exact_synonym: mucopolysaccharides
has_related_synonym: Mucopolysaccharid
has_related_synonym: Mukopolysaccharid
has_related_synonym: mucopolisacarido
has_related_synonym: mucopolisacaridos
id: CHEBI:37395
in subset: 3 STAR

acid
type: Class
subclass of: chemical role
textual definition: An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:13800
has_alternative_id: CHEBI:13801
has_alternative_id: CHEBI:22209
has_alternative_id: CHEBI:2426
database_cross_reference: KEGG:C00174
has_exact_synonym: Acid
has_exact_synonym: acid
has_related_synonym: Saeure
has_related_synonym: Saeuren
has_related_synonym: acide
has_related_synonym: acido
has_related_synonym: acids
id: CHEBI:37527
in subset: 3 STAR

heteroatomic molecular entity
type: Class
subclass of: polyatomic entity
textual definition: A molecular entity consisting of two or more chemical elements.
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: chemical compound
has_related_synonym: heteroatomic molecular entities
id: CHEBI:37577
in subset: 3 STAR

carboxamide
type: Class
subclass of: amide
subclass of: primary amide
subclass of: organonitrogen compound
subclass of: organooxygen compound
subclass of: Restriction
  on property: has part
  some values from: carbamoyl group
textual definition: An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom.
imported from: chebi.owl
imported from: hp.owl
imported from: mondo.owl
charge: 0
formula: CNOR3
mass: 42.01680
monoisotopicmass: 41.99799
smiles: [*]C(=O)N([*])[*]
has_alternative_id: CHEBI:35354
has_alternative_id: CHEBI:35355
has_exact_synonym: carboxamides
has_obo_namespace: chebi_ontology
has_related_synonym: carboxamides
has_related_synonym: primary carboxamide
id: CHEBI:37622
in subset: 3 STAR

carboacyl group
type: Class
subclass of: acyl group
subclass of: Restriction
  on property: is substituent group from
  some values from: carboxylic acid
textual definition: A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: carboacyl groups
has_exact_synonym: carboxylic acyl group
has_related_synonym: carboxylic acyl groups
id: CHEBI:37838
in subset: 3 STAR

polypyrrole
type: Class
subclass of: organonitrogen heterocyclic compound
textual definition: A compound composed of two or more pyrrole units.
imported from: mondo.owl
has_related_synonym: PPys
has_related_synonym: poly(pyrrole)s
has_related_synonym: polypyrroles

organonitrogen heterocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: organonitrogen compound
textual definition: Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.
imported from: chebi.owl
imported from: dron.owl
imported from: mondo.owl
has_obo_namespace: chebi_ontology
has_related_synonym: heterocyclic organonitrogen compounds
has_related_synonym: organonitrogen heterocyclic compounds
id: CHEBI:38101
in subset: 3 STAR

organosulfur heterocyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: organosulfur compound
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: heterocyclic organosulfur compounds
has_related_synonym: organosulfur heterocyclic compounds
id: CHEBI:38106
in subset: 3 STAR

organic heteropolycyclic compound
type: Class
subclass of: organic heterocyclic compound
subclass of: heteropolycyclic compound
imported from: chebi.owl
has_alternative_id: CHEBI:25429
has_alternative_id: CHEBI:38075
has_obo_namespace: chebi_ontology
has_related_synonym: organic heteropolycyclic compounds
id: CHEBI:38166
in subset: 3 STAR

cephem
type: Class
subclass of: organic heterobicyclic compound
subclass of: beta-lactam antibiotic
subclass of: beta-lactam
subclass of: organonitrogen heterocyclic compound
subclass of: organosulfur heterocyclic compound
imported from: chebi.owl
imported from: dron.owl
has_obo_namespace: chebi_ontology
has_related_synonym: cephems
id: CHEBI:38311
in subset: 3 STAR

Bronsted acid
type: Class
subclass of: donor
subclass of: acid
textual definition: A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: Bronsted acid
has_related_synonym: Bronsted-Saeure
has_related_synonym: acide de Bronsted
has_related_synonym: donneur d'hydron
has_related_synonym: hydron donor
id: CHEBI:39141
in subset: 3 STAR

Bronsted base
type: Class
subclass of: acceptor
subclass of: base
textual definition: A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: Bronsted base
has_related_synonym: Bronsted-Base
has_related_synonym: accepteur d'hydron
has_related_synonym: base de Bronsted
has_related_synonym: hydron acceptor
id: CHEBI:39142
in subset: 3 STAR

Lewis base
type: Class
subclass of: donor
subclass of: base
textual definition: A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: Lewis base
has_related_synonym: Lewis-Base
has_related_synonym: base de Lewis
has_related_synonym: donneur d'une paire d'electrons
has_related_synonym: electron donor
id: CHEBI:39144
in subset: 3 STAR

hydroxy group
type: Class
subclass of: inorganic group
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:24706
has_alternative_id: CHEBI:43171
database_cross_reference: PDBeChem:OH
has_exact_synonym: HYDROXY GROUP
has_exact_synonym: hydroxy
has_exact_synonym: hydroxy group
has_related_synonym: -OH
has_related_synonym: hydroxyl
has_related_synonym: hydroxyl group
id: CHEBI:43176
in subset: 3 STAR

oxo group
type: Class
subclass of: inorganic group
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:29353
has_alternative_id: CHEBI:44607
database_cross_reference: PDBeChem:O
has_exact_synonym: OXO GROUP
has_exact_synonym: oxo
has_related_synonym: =O
id: CHEBI:46629
in subset: 3 STAR

carboxy group
type: Class
subclass of: organyl group
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:23025
has_alternative_id: CHEBI:41420
database_cross_reference: PDBeChem:FMT
has_exact_synonym: CARBOXY GROUP
has_exact_synonym: carboxy
has_related_synonym: -C(O)OH
has_related_synonym: -CO2H
has_related_synonym: -COOH
has_related_synonym: carboxyl group
id: CHEBI:46883
in subset: 3 STAR

cyclic polypyrrole
type: Class
subclass of: polypyrrole
imported from: mondo.owl
has_exact_synonym: macrocyclic polypyrroles
has_related_synonym: cyclic polypyrroles
has_related_synonym: polypyrrole macrocycles

protein synthesis inhibitor
type: Class
subclass of: pathway inhibitor
textual definition: A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
imported from: mondo.owl
has_related_synonym: protein synthesis antagonist
has_related_synonym: protein synthesis antagonists
has_related_synonym: protein synthesis inhibitors

agonist
type: Class
subclass of: pharmacological role
textual definition: Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own.
imported from: mondo.owl
has_exact_synonym: agonist
has_related_synonym: agonista
has_related_synonym: agoniste
has_related_synonym: agonists

hydrogen atom
type: Class
subclass of: inorganic molecular entity
subclass of: nonmetal atom
subclass of: s-block element atom
subclass of: Restriction
  on property: has role
  some values from: macronutrient
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:24634
has_alternative_id: CHEBI:49636
database_cross_reference: WebElements:H
has_exact_synonym: hydrogen
has_related_synonym: 1H
has_related_synonym: H
has_related_synonym: Wasserstoff
has_related_synonym: hidrogeno
has_related_synonym: hydrogen
has_related_synonym: hydrogene
id: CHEBI:49637
in subset: 3 STAR

organic amino compound
type: Class
subclass of: organonitrogen compound
subclass of: organic molecular entity
subclass of: Restriction
  on property: has role
  some values from: Bronsted base
subclass of: Restriction
  on property: has parent hydride
  some values from: ammonia
textual definition: A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: organic amino compounds
id: CHEBI:50047
in subset: 3 STAR

onium compound
type: Class
subclass of: heteroatomic molecular entity
imported from: hp.owl
imported from: mondo.owl
id: CHEBI:50312
in subset: 1 STAR

onium cation
type: Class
subclass of: onium compound
textual definition: Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families.
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: onium cations
has_related_synonym: onium cations
has_related_synonym: onium ion
has_related_synonym: onium ions
id: CHEBI:50313
in subset: 3 STAR

nutraceutical
type: Class
subclass of: drug
textual definition: A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
imported from: mondo.owl
has_related_synonym: Dietary Supplement
has_related_synonym: Food Supplementation
has_related_synonym: Nutritional supplement

corticosteroid
type: Class
subclass of: steroid
textual definition: A natural or synthetic analogue of the hormones secreted by the adrenal gland.
imported from: mondo.owl
has_related_synonym: corticoides
has_related_synonym: corticosteroides
has_related_synonym: corticosteroids

organic molecular entity
type: Class
subclass of: carbon group molecular entity
subclass of: p-block molecular entity
subclass of: Restriction
  on property: has part
  some values from: carbon atom
textual definition: Any molecular entity that contains carbon.
imported from: chebi.owl
imported from: cl.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:25700
has_alternative_id: CHEBI:33244
has_obo_namespace: chebi_ontology
has_related_synonym: organic compounds
has_related_synonym: organic entity
has_related_synonym: organic molecular entities
id: CHEBI:50860
in subset: 3 STAR

carcinogenic agent
type: Class
subclass of: aetiopathogenetic role
textual definition: A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
imported from: mondo.owl
has_related_synonym: agente carcinogeno
has_related_synonym: cancerigene
has_related_synonym: cancerogene
has_related_synonym: carcinogen
has_related_synonym: carcinogene
has_related_synonym: carcinogenic agents
has_related_synonym: carcinogeno
has_related_synonym: carcinogens

allergen
type: Class
subclass of: aetiopathogenetic role
textual definition: A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.
imported from: mondo.owl
has_related_synonym: alergeno
has_related_synonym: allergene
has_related_synonym: allergenic agent

role
type: Class
subclass of: PATO_0000001
textual definition: A role is particular behaviour which a material entity may exhibit.
imported from: hp.owl
id: CHEBI:50906
in subset: 3 STAR

neurotoxin
type: Class
subclass of: aetiopathogenetic role
subclass of: poison
textual definition: A poison that interferes with the functions of the nervous system.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:50911
database_cross_reference: Wikipedia:Neurotoxin
has_related_synonym: agente neurotoxico
has_related_synonym: nerve poison
has_related_synonym: nerve poisons
has_related_synonym: neurotoxic agent
has_related_synonym: neurotoxic agents
has_related_synonym: neurotoxicant
has_related_synonym: neurotoxins
id: CHEBI:50910
in subset: 3 STAR

hormone receptor modulator
type: Class
subclass of: receptor modulator
textual definition: A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
imported from: mondo.owl
has_related_synonym: hormone receptor modulators

chemical role
type: Class
subclass of: role
textual definition: A role played by the molecular entity or part thereof within a chemical context.
imported from: hp.owl
imported from: mondo.owl
id: CHEBI:51086
in subset: 3 STAR

nitrogen molecular entity
type: Class
subclass of: pnictogen molecular entity
subclass of: p-block molecular entity
subclass of: FOODON_03412972
subclass of: Restriction
  on property: has part
  some values from: nitrogen atom
imported from: chebi.owl
imported from: dron.owl
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:25556
has_alternative_id: CHEBI:7594
database_cross_reference: KEGG COMPOUND:C06061
database_cross_reference: KEGG:C06061
has_obo_namespace: chebi_ontology
has_related_synonym: Nitrogenous compounds
has_related_synonym: nitrogen compounds
has_related_synonym: nitrogen molecular entities
id: CHEBI:51143
in subset: 3 STAR

dipolar compound
type: Class
subclass of: organic molecule
textual definition: An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: dipolar compounds
id: CHEBI:51151
in subset: 3 STAR

acenes
type: Class
subclass of: benzenoid aromatic compound
textual definition: Polycyclic aromatic hydrocarbons consisting of fused benzene rings in a rectilinear arrangement and their substitution derivatives.
imported from: mondo.owl

tetracenes
type: Class
subclass of: acenes
textual definition: Compounds containing a tetracene skeleton.
imported from: mondo.owl
has_related_synonym: naphthacenes

organodiyl group
type: Class
subclass of: organic divalent group
textual definition: Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s).
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: organodiyl groups
id: CHEBI:51422
in subset: 3 STAR

organic divalent group
type: Class
subclass of: organic group
imported from: hp.owl
imported from: mondo.owl
id: CHEBI:51446
in subset: 1 STAR

organic univalent group
type: Class
subclass of: organic group
imported from: hp.owl
imported from: mondo.owl
id: CHEBI:51447
in subset: 1 STAR

organic polycyclic compound
type: Class
subclass of: polycyclic compound
subclass of: organic cyclic compound
imported from: mondo.owl
has_related_synonym: organic polycyclic compounds

biochemical role
type: Class
subclass of: biological role
textual definition: A biological role played by the molecular entity or part thereof within a biochemical context.
imported from: hp.owl
imported from: mondo.owl
id: CHEBI:52206
in subset: 3 STAR

aetiopathogenetic role
type: Class
subclass of: biological role
textual definition: A role played by the molecular entity or part thereof which causes the development of a pathological process.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: etiopathogenetic agent
has_related_synonym: etiopathogenetic role
id: CHEBI:52209
in subset: 3 STAR

pharmacological role
type: Class
subclass of: biological role
textual definition: A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties.
imported from: mondo.owl

physiological role
type: Class
subclass of: biological role
imported from: chebi.owl
imported from: hp.owl
imported from: mondo.owl
id: CHEBI:52211
in subset: 1 STAR

pharmaceutical
type: Class
subclass of: application
textual definition: Any substance introduced into a living organism with therapeutic or diagnostic purpose.
imported from: mondo.owl
has_related_synonym: farmaco
has_related_synonym: medicament
has_related_synonym: pharmaceuticals

oxyketone
type: Class
subclass of: ketone
textual definition: A compound with the general formula R2C=O (R=/=H) where one or more of the R groups contains an oxy (-O-) group.
imported from: mondo.owl
has_related_synonym: oxyketones

alpha-oxyketone
type: Class
subclass of: oxyketone
textual definition: An oxyketone with the general formula R2C(=O) (R=/=H) where one or more of the R groups contains an oxy (-O-) group and the oxy and carbonyl groups are bonded to the same carbon atom.
imported from: mondo.owl
has_related_synonym: alpha-oxyketones

polyanionic macromolecule
type: Class
subclass of: macromolecule
subclass of: ionic macromolecule
textual definition: A polymer carrying multiple negative charges.
imported from: hp.owl
has_related_synonym: polyanion
has_related_synonym: polyanions
id: CHEBI:53309
in subset: 3 STAR

ionic macromolecule
type: Class
subclass of: macromolecule
textual definition: A macromolecule containing ionic groups.
imported from: hp.owl
has_related_synonym: ionic polymer
has_related_synonym: polyionic macromolecule
id: CHEBI:53368
in subset: 3 STAR

globin
type: Class
subclass of: hemoprotein
imported from: mondo.owl
has_exact_synonym: Globin
has_related_synonym: globins
has_related_synonym: pentacoordinate globin

heterocyclic compound
type: Class
subclass of: cyclic compound
textual definition: A cyclic compound having as ring members atoms of at least two different elements.
imported from: chebi.owl
imported from: dron.owl
imported from: mondo.owl
has_exact_synonym: Heterocyclic compound
has_obo_namespace: chebi_ontology
has_related_synonym: compuesto heterociclico
has_related_synonym: compuestos heterociclicos
has_related_synonym: heterocycle
has_related_synonym: heterocyclic compounds
id: CHEBI:5686
in subset: 3 STAR

nucleophilic reagent
type: Class
subclass of: reagent
subclass of: Lewis base
textual definition: A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: nucleophile
has_related_synonym: nucleophiles
has_related_synonym: nucleophilic reagents
id: CHEBI:59740
in subset: 3 STAR

chemical substance
type: Class
subclass of: chemical entity
textual definition: A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types.
imported from: hp.owl
has_related_synonym: Chemische Substanz
id: CHEBI:59999
in subset: 3 STAR

mixture
type: Class
subclass of: chemical substance
textual definition: A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind.
imported from: hp.owl
has_related_synonym: Mischung
id: CHEBI:60004
in subset: 3 STAR

polymer
type: Class
subclass of: mixture
subclass of: Restriction
  on property: has part
  some values from: macromolecule
textual definition: A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc..
imported from: hp.owl
database_cross_reference: Wikipedia:Polymer
has_exact_synonym: Polymer
has_related_synonym: Kunststoff
id: CHEBI:60027
in subset: 3 STAR

ionic polymer
type: Class
subclass of: polymer
subclass of: Restriction
  on property: has part
  some values from: ionic macromolecule
textual definition: An ionic polymer is a polymer, composed of ionic macromolecules.
imported from: hp.owl
has_related_synonym: polyionic polymer
id: CHEBI:60164
in subset: 3 STAR

monovalent inorganic cation
type: Class
subclass of: inorganic cation
textual definition: An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: a monovalent cation
id: CHEBI:60242
in subset: 3 STAR

peptide zwitterion
type: Class
subclass of: zwitterion
subclass of: Restriction
  on property: is tautomer of
  some values from: peptide
textual definition: Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: a peptide
has_related_synonym: peptide zwitterions
id: CHEBI:60466
in subset: 3 STAR

polyanionic polymer
type: Class
subclass of: ionic polymer
subclass of: Restriction
  on property: has part
  some values from: polyanionic macromolecule
textual definition: A polymer, composed of polyanion macromolecules.
imported from: hp.owl
has_related_synonym: polyanion
has_related_synonym: polyanions
id: CHEBI:61469
in subset: 3 STAR

carbohydrate derivative
type: Class
subclass of: carbohydrates and carbohydrate derivatives
subclass of: Restriction
  on property: has functional parent
  some values from: carbohydrate
textual definition: Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds.
imported from: hp.owl
has_related_synonym: carbohydrate derivatives
has_related_synonym: derivatised carbohydrate
has_related_synonym: derivatised carbohydrates
has_related_synonym: derivatized carbohydrate
has_related_synonym: derivatized carbohydrates
id: CHEBI:63299
in subset: 3 STAR

carbohydrate acid derivative
type: Class
subclass of: carbohydrate derivative
subclass of: Restriction
  on property: has functional parent
  some values from: carbohydrate acid
subclass of: Restriction
  on property: is conjugate acid of
  some values from: carbohydrate acid derivative anion
textual definition: A carbohydrate derivative that is formally obtained from a carbohydrate acid.
imported from: hp.owl
has_related_synonym: carbohydrate acid derivatives
id: CHEBI:63436
in subset: 3 STAR

carbohydrate acid derivative anion
type: Class
subclass of: carboxylic acid anion
subclass of: Restriction
  on property: has functional parent
  some values from: carbohydrate acid anion
subclass of: Restriction
  on property: is conjugate base of
  some values from: carbohydrate acid derivative
textual definition: A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative.
imported from: hp.owl
has_related_synonym: carbohydrate acid anion derivative
has_related_synonym: carbohydrate acid anion derivatives
has_related_synonym: carbohydrate acid derivative anions
id: CHEBI:63551
in subset: 3 STAR

one-carbon compound
type: Class
subclass of: organic molecular entity
textual definition: An organic molecular entity containing a single carbon atom (C1).
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: one-carbon compounds
id: CHEBI:64708
in subset: 3 STAR

organic acid
type: Class
subclass of: organic molecular entity
textual definition: Any organic molecular entity that is acidic and contains carbon in covalent linkage.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: organic acids
id: CHEBI:64709
in subset: 3 STAR

poison
type: Class
subclass of: biological role
textual definition: Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism.
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: Wikipedia:Poison
has_related_synonym: poisonous agent
has_related_synonym: poisonous agents
has_related_synonym: poisonous substance
has_related_synonym: poisonous substances
has_related_synonym: poisons
has_related_synonym: toxic agent
has_related_synonym: toxic agents
has_related_synonym: toxic substance
has_related_synonym: toxic substances
id: CHEBI:64909
in subset: 3 STAR

polysaccharide derivative
type: Class
subclass of: glycan
subclass of: biomacromolecule
subclass of: carbohydrate derivative
subclass of: Restriction
  on property: has functional parent
  some values from: polysaccharide
textual definition: A carbohydrate derivative that is any derivative of a polysaccharide.
imported from: hp.owl
has_related_synonym: polysaccharide derivatives
id: CHEBI:65212
in subset: 3 STAR

tetracycline(1-)
type: Class
subclass of: organic anion
subclass of: Restriction
  on property: is conjugate base of
  some values from: tetracycline
subclass of: Restriction
  on property: is conjugate base of
  some values from: tetracycline zwitterion
textual definition: An organic anion that is the conjugate base of tetracycline obtained by deprotonation of the two enolic hydroxy groups and protonation of the tertiary amino group.
imported from: mondo.owl
has_exact_synonym: (1S,4aS,11S,11aS,12aS)-3-carbamoyl-1-(dimethylazaniumyl)-4a,7,11-trihydroxy-11-methyl-4,6-dioxo-1,4,4a,6,11,11a,12,12a-octahydrotetracene-2,5-diolate
has_related_synonym: tetracycline anion

organic molecule
type: Class
subclass of: molecule
subclass of: organic molecular entity
textual definition: Any molecule that consists of at least one carbon atom as part of the electrically neutral entity.
imported from: chebi.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: chebi_ontology
has_related_synonym: organic compound
has_related_synonym: organic compounds
has_related_synonym: organic molecules
id: CHEBI:72695
in subset: 3 STAR

exopolysaccharide
type: Class
subclass of: biomacromolecule
textual definition: A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment.
imported from: hp.owl
database_cross_reference: MetaCyc:Exopolysaccharides
database_cross_reference: Wikipedia:Exopolysaccharide
database_cross_reference: Wikipedia:Extracellular_polymeric_substance
has_related_synonym: exopolysaccharides
has_related_synonym: extracellular polymeric substance
has_related_synonym: extracellular polymeric substances
id: CHEBI:72813
in subset: 3 STAR

eukaryotic metabolite
type: Class
subclass of: metabolite
textual definition: Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: eukaryotic metabolites
id: CHEBI:75763
in subset: 3 STAR

animal metabolite
type: Class
subclass of: eukaryotic metabolite
textual definition: Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:77721
has_alternative_id: CHEBI:77743
has_related_synonym: animal metabolites
id: CHEBI:75767
in subset: 3 STAR

mammalian metabolite
type: Class
subclass of: animal metabolite
textual definition: Any animal metabolite produced during a metabolic reaction in mammals.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:77464
has_alternative_id: CHEBI:77744
has_related_synonym: mammalian metabolites
id: CHEBI:75768
in subset: 3 STAR

B vitamin
type: Class
subclass of: water-soluble vitamin
subclass of: nutraceutical
textual definition: A role played by any of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B). The group comprises of vitamin B1, B2, B3, B5, B6, B7, B9, and B12 (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such). B vitamins play important roles in cell metabolism.
imported from: mondo.owl
has_related_synonym: B vitamins
has_related_synonym: B-group vitamin
has_related_synonym: B-group vitamins
has_related_synonym: vitamin B

mouse metabolite
type: Class
subclass of: mammalian metabolite
textual definition: Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: Mus musculus metabolite
has_related_synonym: Mus musculus metabolites
has_related_synonym: mouse metabolites
id: CHEBI:75771
in subset: 3 STAR

Saccharomyces cerevisiae metabolite
type: Class
subclass of: fungal metabolite
textual definition: Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:76949
has_alternative_id: CHEBI:76951
has_related_synonym: S. cerevisiae metabolite
has_related_synonym: S. cerevisiae metabolites
has_related_synonym: S. cerevisiae secondary metabolite
has_related_synonym: S. cerevisiae secondary metabolites
has_related_synonym: Saccharomyces cerevisiae metabolites
has_related_synonym: Saccharomyces cerevisiae secondary metabolites
has_related_synonym: baker's yeast metabolite
has_related_synonym: baker's yeast metabolites
has_related_synonym: baker's yeast secondary metabolite
has_related_synonym: baker's yeast secondary metabolites
id: CHEBI:75772
in subset: 3 STAR

prokaryotic metabolite
type: Class
subclass of: metabolite
textual definition: Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: prokaryotic metabolites
id: CHEBI:75787
in subset: 3 STAR

EC 3.* (hydrolase) inhibitor
type: Class
subclass of: enzyme inhibitor
textual definition: Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*).
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: Wikipedia:Hydrolase
has_related_synonym: EC 3.* (hydrolase) inhibitors
has_related_synonym: EC 3.* inhibitor
has_related_synonym: EC 3.* inhibitors
has_related_synonym: EC 3.*.*.* inhibitor
has_related_synonym: EC 3.*.*.* inhibitors
has_related_synonym: hydrolase (EC 3.*) inhibitor
has_related_synonym: hydrolase (EC 3.*) inhibitors
has_related_synonym: hydrolase inhibitor
has_related_synonym: hydrolase inhibitors
id: CHEBI:76759
in subset: 3 STAR

EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
type: Class
subclass of: EC 3.* (hydrolase) inhibitor
textual definition: Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*).
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor
has_related_synonym: EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors
has_related_synonym: EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor
has_related_synonym: EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors
has_related_synonym: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors
has_related_synonym: EC 3.5.* inhibitor
has_related_synonym: EC 3.5.* inhibitors
id: CHEBI:76764
in subset: 3 STAR

EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
type: Class
subclass of: EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor
textual definition: An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*).
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors
has_related_synonym: EC 3.5.1.* inhibitor
has_related_synonym: EC 3.5.1.* inhibitors
has_related_synonym: non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor
has_related_synonym: non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors
id: CHEBI:76807
in subset: 3 STAR

pathway inhibitor
type: Class
subclass of: enzyme inhibitor
textual definition: An enzyme inhibitor that interferes with one or more steps in a metabolic pathway.
imported from: mondo.owl
has_related_synonym: metabolic pathway inhibitor
has_related_synonym: metabolic pathway inhibitors
has_related_synonym: pathway inhibitors

fungal metabolite
type: Class
subclass of: eukaryotic metabolite
textual definition: Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:75765
has_alternative_id: CHEBI:76947
has_related_synonym: fungal metabolites
id: CHEBI:76946
in subset: 3 STAR

bacterial metabolite
type: Class
subclass of: prokaryotic metabolite
textual definition: Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:75760
has_alternative_id: CHEBI:76970
id: CHEBI:76969
in subset: 3 STAR

Escherichia coli metabolite
type: Class
subclass of: bacterial metabolite
textual definition: Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: E.coli metabolite
has_related_synonym: E.coli metabolites
has_related_synonym: Escherichia coli metabolites
id: CHEBI:76971
in subset: 3 STAR

human metabolite
type: Class
subclass of: mammalian metabolite
textual definition: Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:75770
has_alternative_id: CHEBI:77123
has_related_synonym: H. sapiens metabolite
has_related_synonym: H. sapiens metabolites
has_related_synonym: Homo sapiens metabolite
has_related_synonym: Homo sapiens metabolites
id: CHEBI:77746
in subset: 3 STAR

tetracycline zwitterion
type: Class
subclass of: a tetracycline zwittterion
subclass of: zwitterion
subclass of: Restriction
  on property: has role
  some values from: antimicrobial agent
subclass of: Restriction
  on property: has role
  some values from: antiprotozoal drug
subclass of: Restriction
  on property: has role
  some values from: antibacterial drug
subclass of: Restriction
  on property: has role
  some values from: protein synthesis inhibitor
subclass of: Restriction
  on property: is conjugate acid of
  some values from: tetracycline(1-)
subclass of: Restriction
  on property: is conjugate base of
  some values from: tetracycline
textual definition: A zwitterion obtained by transfer of a proton from the 2-hydroxy group to the 1-amino group of tetracycline. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).
imported from: mondo.owl
has_exact_synonym: (1S,4aS,11S,11aS,12aS)-3-carbamoyl-1-(dimethylazaniumyl)-4a,5,7,11-tetrahydroxy-11-methyl-4,6-dioxo-1,4,4a,6,11,11a,12,12a-octahydrotetracen-2-olate
has_related_synonym: tetracycline

EC 3.5.1.4 (amidase) inhibitor
type: Class
subclass of: EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor
textual definition: An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4).
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: Wikipedia:Amidase
has_related_synonym: EC 3.5.1.4 (amidase) inhibitors
has_related_synonym: EC 3.5.1.4 inhibitor
has_related_synonym: EC 3.5.1.4 inhibitors
has_related_synonym: N-acetylaminohydrolase inhibitor
has_related_synonym: N-acetylaminohydrolase inhibitors
has_related_synonym: acylamidase inhibitor
has_related_synonym: acylamidase inhibitors
has_related_synonym: acylamide amidohydrolase inhibitor
has_related_synonym: acylamide amidohydrolase inhibitors
has_related_synonym: amidase (EC 3.5.1.4) inhibitor
has_related_synonym: amidase (EC 3.5.1.4) inhibitors
has_related_synonym: amidase inhibitor
has_related_synonym: amidase inhibitors
has_related_synonym: amidohydrolase inhibitor
has_related_synonym: amidohydrolase inhibitors
has_related_synonym: deaminase inhibitor
has_related_synonym: deaminase inhibitors
has_related_synonym: fatty acylamidase inhibitor
has_related_synonym: fatty acylamidase inhibitors
id: CHEBI:77941
in subset: 3 STAR

food component
type: Class
subclass of: physiological role
textual definition: A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants.
textual definition: Any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: dietary component
has_related_synonym: dietary components
has_related_synonym: food components
id: CHEBI:78295
in subset: 3 STAR

refrigerant
type: Class
subclass of: application
textual definition: A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure.
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: Wikipedia:Refrigerant
has_related_synonym: refrigerants
id: CHEBI:78433
in subset: 3 STAR

alpha-amino acid zwitterion
type: Class
subclass of: amino acid zwitterion
subclass of: Restriction
  on property: is tautomer of
  some values from: alpha-amino acid
textual definition: An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3.
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CHEBI:83409
has_related_synonym: an alpha-amino acid
id: CHEBI:78608
in subset: 3 STAR

carbohydrates and carbohydrate derivatives
type: Class
subclass of: organooxygen compound
textual definition: Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation.
imported from: hp.owl
has_related_synonym: carbohydrates and derivatives
has_related_synonym: carbohydrates and their derivatives
id: CHEBI:78616
in subset: 3 STAR

divalent inorganic anion
type: Class
subclass of: inorganic anion
textual definition: Any inorganic anion with a valency of two.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: divalent inorganic anions
id: CHEBI:79388
in subset: 3 STAR

monovalent inorganic anion
type: Class
subclass of: inorganic anion
textual definition: Any inorganic anion with a valency of one.
imported from: hp.owl
imported from: mondo.owl
has_related_synonym: monovalent inorganic anions
id: CHEBI:79389
in subset: 3 STAR

metal allergen
type: Class
subclass of: metal atom
subclass of: Restriction
  on property: has role
  some values from: allergen
textual definition: Any metal which causes the onset of an allergic reaction.
imported from: mondo.owl
has_related_synonym: allergenic metal
has_related_synonym: allergenic metals
has_related_synonym: metal allergens

receptor modulator
type: Class
subclass of: drug
textual definition: A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors.
imported from: mondo.owl
has_related_synonym: receptor modulators

cell line cell
type: Class
subclass of: OBI_0001866
subclass of: Class
  union of: Restriction
    on property: is_specified_output_of
    some values from: OBI_0001867
  union of: Restriction
    on property: derives from
    some values from: Restriction
      on property: is_specified_output_of
      some values from: OBI_0001867
subclass of: Restriction
  on property: derives from
  some values from: primary cultured cell
editor preferred label: cell line cell
editor preferred label: 细胞系细胞 @zh
textual definition: A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture
textual definition: 一个培养细胞，它是一个细胞株（一个稳定的，同质的细胞群，具有共同的生物学起源和增殖史）的一部分
imported from: clo.owl
imported from: obi.owl
label: 细胞系细胞 @zh

immortal cell line cell
type: Class
subclass of: cell line cell
editor preferred label: immortal cell line cell
editor preferred label: 永生细胞系细胞 @zh
textual definition: A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite propagation in vitro as part of an immortal cell line.
textual definition: 预期能够进行无限次分裂的细胞系细胞，作为永生细胞系一部分，能够支持体外无限增殖。
imported from: clo.owl
imported from: obi.owl
label: 永生细胞系细胞 @zh

cell line
type: Class
subclass of: OBI_0001905
subclass of: Restriction
  on property: has grain
  some values from: cell line cell
subclass of: Restriction
  on property: has grain
  all values from: cell line cell
editor preferred label: cell line
editor preferred label: 细胞系 @zh
textual definition: A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture).
textual definition: 一个培养细胞群体，其代表具有共同增殖历史（即已经在培养中一起连续传代）的遗传稳定且同质的培养细胞群体。 @zh
textual definition: 培养的细胞群体代表具有共同繁殖历史（即已经在培养中一起连续传代）的遗传稳定且同质的培养细胞群体。
imported from: clo.owl
imported from: obi.owl
label: 细胞系 @zh

immortal cell line
type: Class
subclass of: cell line
subclass of: Restriction
  on property: has grain
  some values from: immortal cell line cell
subclass of: Restriction
  on property: has grain
  all values from: immortal cell line cell
editor preferred label: immortal cell line
textual definition: A cell line that is expected to be capable of indefinite propagation in an vitro culture.
imported from: clo.owl
imported from: obi.owl

cell
type: Class
subclass of: material entity
subclass of: connected anatomical structure
subclass of: UBERON_0000061
subclass of: Restriction
  on property: directly develops from
  all values from: cell
editor preferred label: cell
example of usage: PMID:18089833.Cancer Res. 2007 Dec 15;67(24):12018-25. "...Epithelial cells were harvested from histologically confirmed adenocarcinomas .."
textual definition: A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
imported from: obi.owl
database_cross_reference: CALOHA:TS-2035
database_cross_reference: FBbt:00007002
database_cross_reference: FMA:68646
database_cross_reference: GO:0005623
database_cross_reference: KUPO:0000002
database_cross_reference: MESH:D002477
database_cross_reference: VHOG:0001533
database_cross_reference: WBbt:0004017
database_cross_reference: XAO:0003012
has_obo_namespace: cell
in subset: cellxgene subset
in subset: upper level
comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one).

primary cultured cell
type: Class
subclass of: cultured cell
subclass of: Class
  complement of: Restriction
    on property: is_specified_output_of
    some values from: OBI_0600037
subclass of: Class
  complement of: Restriction
    on property: derives from
    some values from: Class
      intersection of: cultured cell
      intersection of: Restriction
        on property: is_specified_output_of
        some values from: OBI_0600037
editor preferred label: primary cultured cell
textual definition: A cultured cell that is freshly isolated from a organismal source, or derives in culture from such a cell prior to the culture being passaged.
imported from: cl.owl
imported from: obi.owl

native cell
type: Class
subclass of: cell
textual definition: A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment).
imported from: mondo.owl
database_cross_reference: CARO:0000013
has_narrow_synonym: cell in vivo
has_obo_namespace: cell
in subset: upper level
comment: To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12).

early embryonic cell (metazoa)
type: Class
subclass of: embryonic cell (metazoa)
textual definition: A cell found in the embryo before the formation of all the gem layers is complete.
imported from: cl.owl
imported from: hp.owl

cultured cell
type: Class
subclass of: experimentally modified cell in vitro
subclass of: Class
  union of: Restriction
    on property: is_specified_output_of
    some values from: OBI_0600036
  union of: Restriction
    on property: derives from
    some values from: Restriction
      on property: is_specified_output_of
      some values from: OBI_0600036
editor preferred label: cultured cell
textual definition: A cell in vitro that is or has been maintained or propagated as part of a cell culture.
imported from: cl.owl
imported from: obi.owl

stem cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0017145
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0017145
subclass of: precursor cell
subclass of: Restriction
  on property: in taxon
  some values from: NCBITaxon_33208
subclass of: Restriction
  on property: capable of
  some values from: GO_0017145
subclass of: Restriction
  on property: capable of
  some values from: GO_0030154
textual definition: A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: CALOHA:TS-2086
database_cross_reference: FMA:63368
has_exact_synonym: animal stem cell
has_obo_namespace: cell
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas
comment: This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’.

hematopoietic stem cell
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002981
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002244
  intersection of: Restriction
    on property: capable of
    some values from: GO_0048103
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002244
  intersection of: Restriction
    on property: capable of
    some values from: GO_0048103
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002981
subclass of: somatic stem cell
subclass of: hematopoietic cell
subclass of: hematopoietic precursor cell
subclass of: progenitor cell
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001004
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001012
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001024
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001083
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001084
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001839
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001889
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002978
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002981
subclass of: Restriction
  on property: develops from
  some values from: angioblastic mesenchymal cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0002244
textual definition: A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000725
database_cross_reference: CALOHA:TS-0448
database_cross_reference: FMA:70337
database_cross_reference: FMA:86475
database_cross_reference: MESH:D006412
database_cross_reference: VHOG:0001485
has_exact_synonym: HSC
has_exact_synonym: blood forming stem cell
has_exact_synonym: hemopoietic stem cell
has_obo_namespace: cell
has_related_synonym: HSC
has_related_synonym: colony forming unit hematopoietic
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: human reference atlas
comment: Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.

erythroid progenitor cell
type: Class
subclass of: erythroid lineage cell
subclass of: myeloid lineage restricted progenitor cell
subclass of: Restriction
  on property: develops from
  some values from: megakaryocyte-erythroid progenitor cell
textual definition: A progenitor cell committed to the erythroid lineage.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BTO:0004911
has_obo_namespace: cell
has_related_synonym: BFU-E
has_related_synonym: CFU-E
has_related_synonym: blast forming unit erythroid
has_related_synonym: burst forming unit erythroid
has_related_synonym: colony forming unit erythroid
has_related_synonym: erythroid stem cell
in subset: blood and immune upper slim
in subset: cellxgene subset

germ line cell
type: Class
subclass of: cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0022414
textual definition: A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring.
imported from: cl.owl
imported from: hp.owl
in subset: general cell types upper slim
in subset: upper level
comment: Originally this term had some plant germ line cell children.

monoblast
type: Class
equivalent class: Class
  intersection of: monopoietic cell
  intersection of: Restriction
    on property: has part
    some values from: basophilic cytoplasm
  intersection of: Restriction
    on property: has part
    some values from: GO_0000791
  intersection of: Restriction
    on property: has part
    some values from: GO_0005730
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001012
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030224
equivalent class: Class
  intersection of: monopoietic cell
  intersection of: Restriction
    on property: has part
    some values from: CP_0000028
  intersection of: Restriction
    on property: has part
    some values from: GO_0000791
  intersection of: Restriction
    on property: has part
    some values from: GO_0005730
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001012
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030224
subclass of: myeloid cell
subclass of: monopoietic cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: basophilic cytoplasm
subclass of: Restriction
  on property: has part
  some values from: GO_0000791
subclass of: Restriction
  on property: has part
  some values from: GO_0005730
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001012
subclass of: Restriction
  on property: develops from
  some values from: macrophage dendritic cell progenitor
textual definition: A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus.
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: CALOHA:TS-1195
database_cross_reference: FMA:83553
has_obo_namespace: cell
has_related_synonym: CFU-M
has_related_synonym: colony forming unit macrophage
has_related_synonym: colony forming unit monocyte
has_related_synonym: monocyte stem cell
comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.

multi fate stem cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001402
  intersection of: Restriction
    on property: capable of
    some values from: GO_0017145
equivalent class: Class
  intersection of: somatic cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001402
  intersection of: Restriction
    on property: capable of
    some values from: GO_0017145
subclass of: stem cell
subclass of: somatic cell
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0001402
textual definition: A stem cell that can give rise to multiple lineages of cells.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: FMA:84789
has_exact_synonym: multi-fate stem cell
has_exact_synonym: multifate stem cell
has_exact_synonym: multipotent cell
has_exact_synonym: multipotent stem cell
has_obo_namespace: cell

common myeloid progenitor
type: Class
subclass of: hematopoietic oligopotent progenitor cell
textual definition: A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0004730
has_exact_synonym: CMP
has_exact_synonym: common myeloid precursor
has_obo_namespace: cell
has_related_synonym: CFU-GEMM
has_related_synonym: CFU-S
has_related_synonym: CMP
has_related_synonym: colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte
has_related_synonym: multipotential myeloid stem cell
has_related_synonym: myeloid stem cell
has_related_synonym: pluripotent stem cell (bone marrow)
in subset: cellxgene subset
in subset: human reference atlas
comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059).

megakaryocyte-erythroid progenitor cell
type: Class
equivalent class: Class
  intersection of: hematopoietic oligopotent progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030218
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030219
subclass of: myeloid cell
subclass of: hematopoietic oligopotent progenitor cell
subclass of: progenitor cell
subclass of: Restriction
  on property: develops from
  some values from: common myeloid progenitor
subclass of: Restriction
  on property: capable of
  some values from: GO_0030218
subclass of: Restriction
  on property: capable of
  some values from: GO_0030219
textual definition: A progenitor cell committed to the megakaryocyte and erythroid lineages.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_exact_synonym: CFU-EM
has_exact_synonym: CFU-MegE
has_exact_synonym: MEP
has_exact_synonym: Meg/E progenitor
has_exact_synonym: colony forming unit erythroid megakaryocyte
has_exact_synonym: megakaryocyte/erythrocyte progenitor
has_exact_synonym: megakaryocyte/erythroid progenitor cell
has_obo_namespace: cell
in subset: cellxgene subset
in subset: human reference atlas
comment: MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2.

common lymphoid progenitor
type: Class
equivalent class: Class
  intersection of: hematopoietic oligopotent progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030098
subclass of: hematopoietic oligopotent progenitor cell
subclass of: progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030098
textual definition: A oligopotent progenitor cell committed to the lymphoid lineage.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_alternative_id: CL:0000044
has_exact_synonym: CLP
has_exact_synonym: common lymphocyte precursor
has_exact_synonym: common lymphocyte progenitor
has_exact_synonym: common lymphoid precursor
has_obo_namespace: cell
has_related_synonym: CLP
has_related_synonym: ELP
has_related_synonym: committed lymphopoietic stem cell
has_related_synonym: early lymphocyte progenitor
has_related_synonym: lymphoid stem cell
has_related_synonym: lymphopoietic stem cell
in subset: cellxgene subset
in subset: human reference atlas
comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative.

totipotent stem cell
type: Class
subclass of: somatic stem cell
textual definition: A stem cell from which all cells of the body can form.
imported from: cl.owl
imported from: hp.owl
database_cross_reference: FMA:84790
database_cross_reference: MESH:D039901
has_exact_synonym: totipotential stem cell

non-terminally differentiated cell
type: Class
subclass of: cell
subclass of: precursor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030154
textual definition: A precursor cell with a limited number of potential fates.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BTO:0000125
database_cross_reference: FMA:84782
has_exact_synonym: blast cell
has_obo_namespace: cell
in subset: cellxgene subset
comment: define using PATO mulit-potent or oligopotent?

myoblast
type: Class
subclass of: muscle precursor cell
textual definition: A cell that is commited to differentiating into a muscle cell. Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes. Myoblasts also occur as transient populations of cells in muscles undergoing repair.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BTO:0000222
database_cross_reference: CALOHA:TS-0650
database_cross_reference: FBbt:00005083
database_cross_reference: FMA:70335
database_cross_reference: VHOG:0001529
has_obo_namespace: cell

fibroblast
type: Class
subclass of: connective tissue cell
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000730
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000001277
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000001278
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000001634
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000004060
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000009839
subclass of: Restriction
  on property: develops from
  some values from: mesenchymal stem cell
textual definition: A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000452
database_cross_reference: CALOHA:TS-0362
database_cross_reference: FMA:63877
database_cross_reference: NCIT:C12482
database_cross_reference: VHOG:0001482
has_obo_namespace: cell
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas
comment: These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.

ciliated cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: has part
    some values from: GO_0005929
subclass of: cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: GO_0005929
textual definition: A cell that has a filiform extrusion of the cell surface.
imported from: cl.owl
database_cross_reference: VHOG:0001532
database_cross_reference: XAO:0000031
in subset: cellxgene subset

epithelial cell
type: Class
equivalent class: Class
  intersection of: animal cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0000483
subclass of: cell
subclass of: animal cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000483
textual definition: A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000414
database_cross_reference: CALOHA:TS-2026
database_cross_reference: CARO:0000077
database_cross_reference: FBbt:00000124
database_cross_reference: FMA:66768
database_cross_reference: WBbt:0003672
has_exact_synonym: epitheliocyte
has_obo_namespace: cell
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas

ciliated epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: has part
    some values from: GO_0005929
subclass of: ciliated cell
subclass of: epithelial cell
textual definition: An epithelial cell that has a cilia.
imported from: cl.owl
database_cross_reference: FMA:70605
in subset: cellxgene subset

duct epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0000058
subclass of: epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000058
textual definition: An epithelial cell that is part of a duct.
imported from: cl.owl
in subset: cellxgene subset

blood vessel endothelial cell
type: Class
equivalent class: Class
  intersection of: squamous epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004638
subclass of: squamous epithelial cell
subclass of: endothelial cell of vascular tree
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004638
subclass of: Restriction
  on property: develops from
  some values from: embryonic blood vessel endothelial progenitor cell
textual definition: An endothelial cell that lines the vasculature.
imported from: cl.owl
imported from: hp.owl
present_in_taxon: NCBITaxon 9606
has_exact_synonym: cuboidal endothelial cell of vascular tree
in subset: cellxgene subset
in subset: human reference atlas

non-branched duct epithelial cell
type: Class
subclass of: duct epithelial cell
subclass of: meso-epithelial cell
imported from: cl.owl

columnar/cuboidal epithelial cell
type: Class
subclass of: epithelial cell
textual definition: A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
imported from: cl.owl
imported from: hp.owl
present_in_taxon: NCBITaxon 9606
in subset: cellxgene subset
in subset: human reference atlas

squamous epithelial cell
type: Class
subclass of: epithelial cell
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: CALOHA:TS-1249
has_obo_namespace: cell
in subset: cellxgene subset

mesothelial cell
type: Class
subclass of: squamous epithelial cell
subclass of: lining cell
subclass of: meso-epithelial cell
subclass of: Restriction
  on property: develops from
  some values from: mesodermal cell
textual definition: A flattened epithelial cell of mesenchymal origin that lines the serous cavity.
imported from: cl.owl
imported from: hp.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: FMA:66773
has_exact_synonym: mesotheliocyte
in subset: cellxgene subset
in subset: human reference atlas

blood cell
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0008015
subclass of: hematopoietic cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0008015
textual definition: A cell found predominately in the blood.
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: FMA:62844
database_cross_reference: MESH:D001773
has_obo_namespace: cell
in subset: cellxgene subset
in subset: general cell types upper slim

epithelial cell of pancreas
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001264
subclass of: epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: develops from
  some values from: endodermal cell
textual definition: An epithelial cell of the pancreas.
imported from: mondo.owl
database_cross_reference: BTO:0000028
has_exact_synonym: pancreas epithelial cell
has_exact_synonym: pancreatic epithelial cell
has_obo_namespace: cell

T cell
type: Class
equivalent class: Class
  intersection of: lymphocyte
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002456
subclass of: lymphocyte
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000915
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000917
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000919
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000959
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000010225
subclass of: Restriction
  on property: develops from
  some values from: pro-T cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0002456
textual definition: A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000782
database_cross_reference: CALOHA:TS-1001
database_cross_reference: FMA:62870
database_cross_reference: MESH:D013601
database_cross_reference: VHOG:0001479
has_exact_synonym: T lymphocyte
has_exact_synonym: T-cell
has_exact_synonym: T-lymphocyte
has_related_synonym: immature T cell
has_related_synonym: mature T cell
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas

osteoclast
type: Class
equivalent class: Class
  intersection of: myeloid leukocyte
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001474
  intersection of: Restriction
    on property: has part
    some values from: PR_000001850
  intersection of: Restriction
    on property: has part
    some values from: PR_000001937
  intersection of: Restriction
    on property: has part
    some values from: PR_000001944
  intersection of: Restriction
    on property: has part
    some values from: PR_000007597
  intersection of: Restriction
    on property: has part
    some values from: PR_000011178
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001954
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000002062
  intersection of: Restriction
    on property: capable of
    some values from: GO_0045453
subclass of: phagocyte (sensu Vertebrata)
subclass of: myeloid leukocyte
subclass of: bone cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: PR_000001850
subclass of: Restriction
  on property: has part
  some values from: PR_000001937
subclass of: Restriction
  on property: has part
  some values from: PR_000001944
subclass of: Restriction
  on property: has part
  some values from: PR_000007597
subclass of: Restriction
  on property: has part
  some values from: PR_000011178
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001954
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000002062
subclass of: Restriction
  on property: develops from
  some values from: monocyte
subclass of: Restriction
  on property: capable of
  some values from: GO_0045453
textual definition: A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.
imported from: cl.owl
database_cross_reference: BTO:0000968
database_cross_reference: CALOHA:TS-0721
database_cross_reference: FMA:66781
database_cross_reference: MESH:D010010
has_related_synonym: chondroclast
in subset: cellxgene subset
comment: Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.

granulocyte
type: Class
equivalent class: Class
  intersection of: myeloid leukocyte
  intersection of: Restriction
    on property: has part
    some values from: GO_0030141
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001012
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001332
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001969
  intersection of: Restriction
    on property: capable of
    some values from: GO_0008015
subclass of: blood cell
subclass of: myeloid leukocyte
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: GO_0030141
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001024
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001084
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001012
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001332
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001969
textual definition: A leukocyte with abundant granules in the cytoplasm.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000539
database_cross_reference: BTO:0001026
database_cross_reference: CALOHA:TS-0422
database_cross_reference: FMA:62854
has_exact_synonym: granular leucocyte
has_exact_synonym: granular leukocyte
has_exact_synonym: polymorphonuclear leukocyte
in subset: cellxgene subset
in subset: human reference atlas

neuron associated cell
type: Class
subclass of: neural cell
subclass of: Restriction
  on property: develops from
  some values from: neurectodermal cell
imported from: cl.owl
in subset: cellxgene subset

mature neutrophil
type: Class
equivalent class: Class
  intersection of: neutrophil
  intersection of: Restriction
    on property: has part
    some values from: neutrophillic cytoplasm
  intersection of: Restriction
    on property: has part
    some values from: GO_0070820
  intersection of: Restriction
    on property: has part
    some values from: Class
      intersection of: GO_0005634
      intersection of: Restriction
        on property: bearer of
        some values from: PATO_0001979
  intersection of: Restriction
    on property: lacks_part
    some values from: PR_000009978
  intersection of: Restriction
    on property: lacks_part
    some values from: PR_000010543
  intersection of: Restriction
    on property: lacks_part
    some values from: PR_000010799
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001256
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001257
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001456
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001483
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001879
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001944
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000007597
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002536
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002690
  intersection of: Restriction
    on property: capable of
    some values from: GO_0006909
  intersection of: Restriction
    on property: capable of
    some values from: GO_0032637
subclass of: phagocyte
subclass of: neutrophil
subclass of: Restriction
  on property: has part
  some values from: neutrophillic cytoplasm
subclass of: Restriction
  on property: has part
  some values from: GO_0070820
subclass of: Restriction
  on property: has part
  some values from: Class
    intersection of: GO_0005634
    intersection of: Restriction
      on property: bearer of
      some values from: PATO_0001979
subclass of: Restriction
  on property: lacks_part
  some values from: PR_000009978
subclass of: Restriction
  on property: lacks_part
  some values from: PR_000010543
subclass of: Restriction
  on property: lacks_part
  some values from: PR_000010799
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001256
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001257
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001456
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001483
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001944
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000007597
subclass of: Restriction
  on property: capable of
  some values from: GO_0002536
subclass of: Restriction
  on property: capable of
  some values from: GO_0002690
subclass of: Restriction
  on property: capable of
  some values from: GO_0032637
textual definition: A fully differentiated neutrophil, a granular leukocyte having a nucleus with three to five lobes connected by slender threads, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. They are produced in bone marrow at a rate of 5e10-10e10/day and have a half-life of 6-8 hours. Neutrophils are CD15-positive, CD16-positive, CD32-positive, CD43-positive, CD181-positive, and CD182-positive.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: poly
has_broad_synonym: polymorphonuclear leucocyte
has_broad_synonym: polymorphonuclear leukocyte
database_cross_reference: BTO:0003473
has_exact_synonym: PMN
has_exact_synonym: mature neutrocyte
has_exact_synonym: mature neutrophil leucocyte
has_exact_synonym: mature neutrophil leukocyte
has_exact_synonym: mature neutrophilic leucocyte
has_exact_synonym: mature neutrophilic leukocyte
has_exact_synonym: polymorphonuclear neutrophil
has_exact_synonym: polynuclear neutrophilic leucocyte
has_exact_synonym: polynuclear neutrophilic leukocyte
in subset: human reference atlas
comment: Neutrophils are also capable of secreting GRO-alpha, IL-1beta, IL-1ra, IL-3, IL-12, IP-10, MIG, MIP-1alpha, MIP-1beta, TGF-beta, TNF-alpha, VEGF, and anti-microbial peptides. They can positively influence the chemotaxis of basophils, T-cells, monocytes, macrophages, dendritic cells, and other neutrophils. Neutrophils are also CD35-positive, CD64-positive, CD89-positive, CD184-positive, and fMLP receptor-positive Ly-6G-positive (mouse), TLR2-low, TLR4-low, and lineage-negative (CD2, CD3, CD5, CD9, CD19, CD36, CD49d, CD56, CD61, CD235a (glycophorin-A)).

mast cell
type: Class
equivalent class: Class
  intersection of: myeloid leukocyte
  intersection of: Restriction
    on property: has part
    some values from: GO_0030141
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001865
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001255
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000006169
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002349
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002539
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002660
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002690
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002830
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030210
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000002065
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000007431
subclass of: myeloid leukocyte
subclass of: histamine secreting cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: GO_0030141
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001865
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000001359
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000002206
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000003815
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001255
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000006169
subclass of: Restriction
  on property: develops from
  some values from: mast cell progenitor
subclass of: Restriction
  on property: capable of
  some values from: GO_0002349
subclass of: Restriction
  on property: capable of
  some values from: GO_0002539
subclass of: Restriction
  on property: capable of
  some values from: GO_0002660
subclass of: Restriction
  on property: capable of
  some values from: GO_0002690
subclass of: Restriction
  on property: capable of
  some values from: GO_0002830
subclass of: Restriction
  on property: capable of
  some values from: GO_0030210
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000002065
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000007431
textual definition: A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000830
database_cross_reference: CALOHA:TS-0603
database_cross_reference: FMA:66784
has_exact_synonym: histaminocyte
has_exact_synonym: labrocyte
has_exact_synonym: mastocyte
has_related_synonym: tissue basophil
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: human reference atlas
comment: Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.

mononuclear phagocyte
type: Class
equivalent class: Class
  intersection of: phagocyte (sensu Vertebrata)
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001407
subclass of: phagocyte (sensu Vertebrata)
subclass of: mononuclear cell
textual definition: A vertebrate phagocyte with a single nucleus.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0001433
in subset: cellxgene subset
in subset: human reference atlas

endothelial cell
type: Class
subclass of: lining cell
subclass of: meso-epithelial cell
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000002321
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000005175
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000051705
textual definition: An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.
imported from: cl.owl
imported from: hp.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0001176
database_cross_reference: CALOHA:TS-0278
database_cross_reference: FMA:66772
has_exact_synonym: endotheliocyte
in subset: cellxgene subset
in subset: human reference atlas
comment: From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].

glial cell
type: Class
subclass of: neuron associated cell
textual definition: A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.
imported from: cl.owl
database_cross_reference: BTO:0002606
database_cross_reference: CALOHA:TS-0415
database_cross_reference: FBbt:00005144
database_cross_reference: FMA:54536
has_exact_synonym: neuroglial cell
has_related_synonym: neuroglia
in subset: cellxgene subset
in subset: general cell types upper slim
comment: Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571

neurectodermal cell
type: Class
subclass of: ectodermal cell
textual definition: Ectoderm destined to be nervous tissue.
imported from: cl.owl
imported from: hp.owl
has_exact_synonym: neurectoderm cell

mesenchymal stem cell
type: Class
subclass of: multi fate stem cell
subclass of: connective tissue cell
textual definition: A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_alternative_id: CL:0002452
database_cross_reference: BTO:0002625
database_cross_reference: BTO:0003298
database_cross_reference: FMA:70546
has_narrow_synonym: BMSC
has_narrow_synonym: bone marrow stromal cells
has_narrow_synonym: colony-forming unit-fibroblast
has_narrow_synonym: marrow stromal cells
has_obo_namespace: cell
has_related_synonym: BMSC
has_related_synonym: CFU-F
has_related_synonym: MSC
has_related_synonym: mesenchymal precursor cell
has_related_synonym: mesenchymal progenitor cells
has_related_synonym: mesenchymal stem cell
has_related_synonym: mesenchymal stromal cell
has_related_synonym: mesenchymal stromal cells
has_related_synonym: stem cells, mesenchymal
in subset: cellxgene subset
comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.

fibrocyte
type: Class
equivalent class: Class
  intersection of: stromal cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002495
  intersection of: Restriction
    on property: capable of
    some values from: GO_0045766
subclass of: stromal cell
subclass of: Restriction
  on property: develops from
  some values from: fibroblast
subclass of: Restriction
  on property: capable of
  some values from: GO_0002495
subclass of: Restriction
  on property: capable of
  some values from: GO_0045766
textual definition: An inactive fibroblast; cytoplasm is sparse, endoplasmic reticulum is scanty with flattened nucleus. Term used by some histologists; when fibroblasts become relatively inactive in fiber formation. However, this cell has the potential for fibrogenesis in quiescent connective tissue of the adult, as well as during development, other histologists prefer to use the term fibroblast in all circumstances. These cells represent ~0.5% of peripheral blood leukocytes.
imported from: cl.owl
database_cross_reference: FMA:63879
in subset: cellxgene subset
comment: Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A.

professional antigen presenting cell
type: Class
equivalent class: Class
  intersection of: leukocyte
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002504
subclass of: leukocyte
subclass of: Restriction
  on property: capable of
  some values from: GO_0002504
textual definition: A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response.
imported from: cl.owl
imported from: mondo.owl
has_broad_synonym: APC
has_obo_namespace: cell
has_related_synonym: APC
in subset: blood and immune upper slim
in subset: cellxgene subset
comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells.

glandular epithelial cell
type: Class
subclass of: epithelial cell
subclass of: secretory cell
subclass of: somatic cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0006799
textual definition: A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules.
imported from: mondo.owl
database_cross_reference: CALOHA:TS-2085
database_cross_reference: FMA:86494
has_obo_namespace: cell

secretory cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0032940
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0032940
subclass of: cell
subclass of: native cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0032940
textual definition: A cell that specializes in controlled release of one or more substances.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BTO:0003659
database_cross_reference: FMA:86916
has_obo_namespace: cell
in subset: cellxgene subset

protein secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0009306
subclass of: secretory cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0009306
imported from: cl.owl
imported from: mondo.owl
has_obo_namespace: cell

seromucus secreting cell
type: Class
subclass of: secretory cell
imported from: cl.owl
imported from: hp.owl

endocrine cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0060986
subclass of: secretory cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002368
textual definition: A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.
imported from: mondo.owl
database_cross_reference: FMA:83809
has_exact_synonym: endocrinocyte
has_obo_namespace: cell

enteroendocrine cell
type: Class
subclass of: glandular epithelial cell
subclass of: endocrine cell
textual definition: An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas.
imported from: mondo.owl
database_cross_reference: BTO:0003865
database_cross_reference: FMA:62930
has_obo_namespace: cell

peptide hormone secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030072
subclass of: secretory cell
imported from: mondo.owl
has_obo_namespace: cell

insulin secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030073
subclass of: secretory cell
subclass of: protein secreting cell
subclass of: peptide hormone secreting cell
imported from: mondo.owl
database_cross_reference: BTO:0000783
has_obo_namespace: cell

type B pancreatic cell
type: Class
equivalent class: Class
  intersection of: enteroendocrine cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0000006
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030073
subclass of: epithelial cell of pancreas
subclass of: enteroendocrine cell
subclass of: insulin secreting cell
subclass of: pancreatic endocrine cell
subclass of: Restriction
  on property: develops from
  some values from: progenitor cell of endocrine pancreas
textual definition: A cell that secretes insulin and is located towards the center of the islets of Langerhans.
imported from: mondo.owl
has_broad_synonym: beta cell
database_cross_reference: BTO:0000783
database_cross_reference: EV:0200009
database_cross_reference: FMA:70586
database_cross_reference: MA:0002419
database_cross_reference: ncithesaurus:Beta_Cell
has_exact_synonym: B-cell of pancreatic islet
has_exact_synonym: beta cell of pancreatic islet
has_exact_synonym: insulin-secreting cell
has_exact_synonym: pancreatic B cell
has_exact_synonym: pancreatic B-cell
has_exact_synonym: pancreatic beta cell
has_exact_synonym: pancreatic islet core
has_exact_synonym: type B enteroendocrine cell
has_obo_namespace: cell
has_related_synonym: beta cell islet
comment: Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression.

contractile cell
type: Class
subclass of: cell
subclass of: native cell
textual definition: A cell whose primary function is to shorten.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: cell
in subset: cellxgene subset

myofibroblast cell
type: Class
subclass of: contractile cell
subclass of: connective tissue cell
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000059
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000001277
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000006363
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000006366
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000006876
textual definition: An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_exact_synonym: MFB
in subset: cellxgene subset
in subset: human reference atlas
comment: Myofibroblasts are alpha-SMA-positive, CD34-negative, CD45-negative. They are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha.

muscle cell
type: Class
subclass of: contractile cell
subclass of: electrically responsive cell
subclass of: animal cell
subclass of: somatic cell
subclass of: Restriction
  on property: develops from
  some values from: myoblast
textual definition: A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BTO:0000888
database_cross_reference: BTO:0000902
database_cross_reference: CALOHA:TS-2032
database_cross_reference: FBbt:00005074
database_cross_reference: FMA:67328
database_cross_reference: WBbt:0003675
has_exact_synonym: muscle fiber
has_exact_synonym: myocyte
has_obo_namespace: cell
in subset: cellxgene subset

smooth muscle cell
type: Class
subclass of: non-striated muscle cell
subclass of: visceral muscle cell
subclass of: Restriction
  on property: develops from
  some values from: smooth muscle myoblast
textual definition: A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast).
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_alternative_id: CL:0000191
has_broad_synonym: non-striated muscle cell
database_cross_reference: BTO:0004576
database_cross_reference: CALOHA:TS-2159
database_cross_reference: FMA:14072
has_exact_synonym: SMCs
has_exact_synonym: myocytes, smooth muscle
has_exact_synonym: smooth muscle fiber
has_narrow_synonym: non-striated muscle cell
has_obo_namespace: cell
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas

electrically active cell
type: Class
subclass of: cell
subclass of: native cell
textual definition: A cell whose function is determined by the generation or the reception of an electric signal.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: cell

lining cell
type: Class
subclass of: barrier cell
textual definition: A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism.
imported from: cl.owl
imported from: hp.owl
has_exact_synonym: boundary cell

synovial cell
type: Class
subclass of: lining cell
subclass of: meso-epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002217
textual definition: A cell located in the synovial joint.
imported from: cl.owl
imported from: hp.owl
database_cross_reference: CALOHA:TS-0995
has_exact_synonym: synoviocyte

barrier cell
type: Class
subclass of: cell
textual definition: A cell whose primary function is to prevent the transport of stuff across compartments.
imported from: cl.owl
imported from: hp.owl

motile cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0048870
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0048870
subclass of: cell
subclass of: native cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0048870
textual definition: A cell that moves by its own activities.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: cell

ectodermal cell
type: Class
subclass of: embryonic cell (metazoa)
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000924
textual definition: A cell of the outer of the three germ layers of the embryo.
imported from: cl.owl
imported from: hp.owl
database_cross_reference: FMA:72549
has_exact_synonym: ectoderm cell

mesodermal cell
type: Class
subclass of: embryonic cell (metazoa)
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000926
textual definition: A cell of the middle germ layer of the embryo.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: FMA:72554
has_exact_synonym: mesoblast
has_exact_synonym: mesoderm cell
has_obo_namespace: cell
in subset: cellxgene subset

endodermal cell
type: Class
subclass of: embryonic cell (metazoa)
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000925
textual definition: A cell of the inner of the three germ layers of the embryo.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: FMA:72555
has_exact_synonym: endoderm cell
has_obo_namespace: cell

anucleate cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001405
subclass of: native cell
textual definition: A cell that lacks a nucleus.
imported from: mondo.owl
database_cross_reference: FMA:68647
has_exact_synonym: non-nucleated cell
has_obo_namespace: cell

single nucleate cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001407
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001407
subclass of: native cell
subclass of: nucleate cell
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0001407
textual definition: A cell with a single nucleus.
imported from: cl.owl
imported from: mondo.owl
has_obo_namespace: cell

erythrocyte
type: Class
equivalent class: Class
  intersection of: erythroid lineage cell
  intersection of: Restriction
    on property: lacks_part
    some values from: GO_0005840
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001945
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0002039
  intersection of: Restriction
    on property: capable of
    some values from: GO_0008015
  intersection of: Restriction
    on property: capable of
    some values from: GO_0015671
equivalent class: Class
  intersection of: erythroid lineage cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0002039
  intersection of: Restriction
    on property: capable of
    some values from: GO_0008015
  intersection of: Restriction
    on property: capable of
    some values from: GO_0015671
  intersection of: Restriction
    on property: lacks_part
    some values from: GO_0005840
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001945
subclass of: blood cell
subclass of: oxygen accumulating cell
subclass of: erythroid lineage cell
subclass of: Restriction
  on property: lacks_part
  some values from: GO_0005840
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001945
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0002039
subclass of: Restriction
  on property: develops from
  some values from: reticulocyte
textual definition: A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000424
database_cross_reference: CALOHA:TS-0290
database_cross_reference: FMA:81100
has_exact_synonym: RBC
has_exact_synonym: red blood cell
has_obo_namespace: cell
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: human reference atlas

platelet
type: Class
equivalent class: Class
  intersection of: myeloid cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001405
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001874
  intersection of: Restriction
    on property: capable of
    some values from: GO_0007596
  intersection of: Restriction
    on property: capable of
    some values from: GO_0008015
subclass of: blood cell
subclass of: anucleate cell
subclass of: serotonin secreting cell
subclass of: myeloid cell
subclass of: Restriction
  on property: develops from
  some values from: megakaryocyte
subclass of: Restriction
  on property: capable of
  some values from: GO_0001820
textual definition: A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.
imported from: mondo.owl
database_cross_reference: BTO:0000132
database_cross_reference: CALOHA:TS-0803
database_cross_reference: FMA:62851
has_exact_synonym: anucleate thrombocyte
has_exact_synonym: blood platelet
has_exact_synonym: enucleate thrombocyte
has_obo_namespace: cell
comment: Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF.

phagocyte
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0006909
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0006909
subclass of: motile cell
subclass of: stuff accumulating cell
subclass of: defensive cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0006909
textual definition: Any cell capable of ingesting particulate matter via phagocytosis.
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: BTO:0001044
database_cross_reference: FMA:83806
database_cross_reference: MESH:D010586
has_obo_namespace: cell
in subset: cellxgene subset

macrophage
type: Class
equivalent class: Class
  intersection of: myeloid leukocyte
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002504
  intersection of: Restriction
    on property: capable of
    some values from: GO_0006909
  intersection of: Restriction
    on property: capable of
    some values from: GO_0031268
subclass of: mononuclear phagocyte
subclass of: professional antigen presenting cell
subclass of: phagocyte
subclass of: myeloid leukocyte
subclass of: Restriction
  on property: develops from
  some values from: monocyte
subclass of: Restriction
  on property: capable of
  some values from: GO_0031268
textual definition: A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000801
database_cross_reference: CALOHA:TS-0587
database_cross_reference: FMA:63261
database_cross_reference: FMA:83585
database_cross_reference: MESH:D008264
has_exact_synonym: histiocyte
has_obo_namespace: cell
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas
comment: Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.

B cell
type: Class
equivalent class: Class
  intersection of: lymphocyte of B lineage
  intersection of: Restriction
    on property: capable of
    some values from: GO_0019724
subclass of: lymphocyte of B lineage
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000931
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000973
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000003512
subclass of: Restriction
  on property: develops from
  some values from: pro-B cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0019724
textual definition: A lymphocyte of B lineage that is capable of B cell mediated immunity.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000776
database_cross_reference: CALOHA:TS-0068
database_cross_reference: FMA:62869
database_cross_reference: MESH:D001402
database_cross_reference: VHOG:0001480
has_exact_synonym: B lymphocyte
has_exact_synonym: B-cell
has_exact_synonym: B-lymphocyte
has_obo_namespace: cell
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas

brush border epithelial cell
type: Class
subclass of: ciliated epithelial cell
subclass of: columnar/cuboidal epithelial cell
imported from: cl.owl

transitional epithelial cell
type: Class
subclass of: epithelial cell
subclass of: somatic cell
textual definition: A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: FMA:66778
has_obo_namespace: cell
in subset: human reference atlas

eukaryotic cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: only in taxon
    some values from: NCBITaxon 2759
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: only in taxon
    some values from: NCBITaxon 2759
subclass of: cell
subclass of: native cell
subclass of: Restriction
  on property: only in taxon
  some values from: NCBITaxon 2759
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: MESH:D005057
has_obo_namespace: cell
in subset: cellxgene subset

serous secreting cell
type: Class
subclass of: seromucus secreting cell
textual definition: Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid.
imported from: cl.owl
imported from: hp.owl
database_cross_reference: BTO:0003687
database_cross_reference: FMA:62511
has_exact_synonym: serous cell
in subset: cellxgene subset

stuff accumulating cell
type: Class
subclass of: cell
subclass of: native cell
textual definition: A cell that is specialised to accumulate a particular substance(s).
imported from: cl.owl
imported from: mondo.owl
has_obo_namespace: cell
in subset: upper level

oxygen accumulating cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0015671
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0015671
subclass of: cell
subclass of: native cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0015671
imported from: cl.owl
imported from: mondo.owl
has_obo_namespace: cell

migratory neural crest cell
type: Class
subclass of: cell
subclass of: motile cell
subclass of: neural crest cell
subclass of: progenitor cell
subclass of: Restriction
  on property: develops from
  some values from: premigratory neural crest cell
textual definition: A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body.
imported from: cl.owl
imported from: hp.owl
database_cross_reference: FMA:86667

mesenchyme condensation cell
type: Class
subclass of: mesenchymal cell
textual definition: A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors.
imported from: cl.owl
imported from: hp.owl

epiblast cell
type: Class
subclass of: totipotent stem cell
textual definition: A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation.
imported from: cl.owl
imported from: hp.owl

blastemal cell
type: Class
subclass of: multi fate stem cell
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: ncithesaurus:Blastemal_Cell
has_exact_synonym: blastema cell
has_obo_namespace: cell

vascular associated smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002049
subclass of: smooth muscle cell
subclass of: perivascular cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002049
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000059
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000004162
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000004629
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000004916
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000006876
textual definition: A smooth muscle cell associated with the vasculature.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_exact_synonym: VSMC
has_exact_synonym: vascular smooth muscle cell
in subset: cellxgene subset
in subset: human reference atlas

animal zygote
type: Class
equivalent class: Class
  intersection of: zygote
  intersection of: Restriction
    on property: only in taxon
    some values from: NCBITaxon_33208
subclass of: early embryonic cell (metazoa)
subclass of: eukaryotic cell
subclass of: zygote
subclass of: Restriction
  on property: only in taxon
  some values from: NCBITaxon_33208
textual definition: Diploid cell produced by the fusion of sperm cell nucleus and egg cell.
imported from: cl.owl
imported from: hp.owl
has_broad_synonym: zygote
database_cross_reference: BTO:0000854
database_cross_reference: EHDAA2:0004546
database_cross_reference: FMA:72395

electrically responsive cell
type: Class
subclass of: electrically active cell
textual definition: A cell whose function is determined by its response to an electric signal.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: cell

electrically signaling cell
type: Class
subclass of: electrically active cell
textual definition: A cell that initiates an electrical signal and passes that signal to another cell.
imported from: cl.owl
imported from: hp.owl

excretory cell
type: Class
subclass of: secretory cell
textual definition: A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids.
imported from: cl.owl
database_cross_reference: WBbt:0005812

dendritic cell
type: Class
equivalent class: Class
  intersection of: leukocyte
  intersection of: Restriction
    on property: has part
    some values from: GO_0042613
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001003
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001407
  intersection of: Restriction
    on property: capable of
    some values from: GO_0001816
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002504
  intersection of: Restriction
    on property: capable of
    some values from: GO_0019882
  intersection of: Restriction
    on property: capable of
    some values from: GO_0045580
subclass of: mononuclear phagocyte
subclass of: professional antigen presenting cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: GO_0042613
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001003
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001024
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000348
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000911
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000913
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000002205
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000002322
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000003687
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000283420
subclass of: Restriction
  on property: capable of
  some values from: GO_0001816
subclass of: Restriction
  on property: capable of
  some values from: GO_0045580
textual definition: A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0002042
database_cross_reference: CALOHA:TS-0194
database_cross_reference: FMA:83036
database_cross_reference: MESH:D003713
has_related_synonym: interdigitating cell
has_related_synonym: veiled cell
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas

biogenic amine secreting cell
type: Class
subclass of: secretory cell
imported from: cl.owl
imported from: mondo.owl
has_obo_namespace: cell

serotonin secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0001820
subclass of: biogenic amine secreting cell
textual definition: A cell type that secretes 5-Hydroxytryptamine (serotonin).
imported from: mondo.owl
has_exact_synonym: 5-HT secreting cell
has_exact_synonym: 5-Hydroxytryptamine secreting cell
has_obo_namespace: cell

defensive cell
type: Class
subclass of: cell
subclass of: native cell
textual definition: A cell whose primary function is to protect the organism.
imported from: cl.owl
imported from: mondo.owl
has_obo_namespace: cell

stromal cell
type: Class
subclass of: connective tissue cell
subclass of: Restriction
  on property: develops from
  some values from: mesenchymal stem cell
textual definition: A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0002064
database_cross_reference: FMA:83624
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas

smooth muscle myoblast
type: Class
equivalent class: Class
  intersection of: myoblast
  intersection of: Restriction
    on property: develops into
    some values from: smooth muscle cell
subclass of: myoblast
subclass of: Restriction
  on property: develops into
  some values from: smooth muscle cell
textual definition: A precursor cell destined to differentiate into smooth muscle myocytes.
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: FMA:84798
has_exact_synonym: myoblast, smooth muscle
has_obo_namespace: cell
has_related_synonym: satellite cell
in subset: cellxgene subset

phagocyte (sensu Vertebrata)
type: Class
subclass of: phagocyte
subclass of: eukaryotic cell
subclass of: Restriction
  on property: only in taxon
  some values from: NCBITaxon 7742
textual definition: A phagocyte in vertebrates that is able to phagocytosis.
imported from: cl.owl

neuron
type: Class
subclass of: electrically responsive cell
subclass of: electrically signaling cell
subclass of: neural cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0019226
textual definition: The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
imported from: cl.owl
imported from: hp.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000938
database_cross_reference: CALOHA:TS-0683
database_cross_reference: FBbt:00005106
database_cross_reference: FMA:54527
database_cross_reference: VHOG:0001483
database_cross_reference: WBbt:0003679
has_exact_synonym: nerve cell
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas
comment: These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma.

lymphocyte
type: Class
equivalent class: Class
  intersection of: leukocyte
  intersection of: Restriction
    on property: has part
    some values from: neutrophillic cytoplasm
  intersection of: Restriction
    on property: has part
    some values from: GO_0000792
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001407
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0040072
equivalent class: Class
  intersection of: leukocyte
  intersection of: Restriction
    on property: has part
    some values from: CP_0000000
  intersection of: Restriction
    on property: has part
    some values from: CP_0000037
  intersection of: Restriction
    on property: has part
    some values from: GO_0000792
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001407
subclass of: leukocyte
subclass of: mononuclear cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: neutrophillic cytoplasm
subclass of: Restriction
  on property: has part
  some values from: GO_0000792
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0040072
subclass of: Restriction
  on property: develops from
  some values from: common lymphoid progenitor
textual definition: A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000775
database_cross_reference: CALOHA:TS-0583
database_cross_reference: FMA:62863
database_cross_reference: MESH:D008214
database_cross_reference: VHOG:0001535
has_obo_namespace: cell
in subset: cellxgene subset
in subset: human reference atlas
comment: Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)

proerythroblast
type: Class
equivalent class: Class
  intersection of: erythroid lineage cell
  intersection of: Restriction
    on property: has part
    some values from: basophilic cytoplasm
  intersection of: Restriction
    on property: has part
    some values from: GO_0005730
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0002505
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0040072
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001945
equivalent class: Class
  intersection of: erythroid lineage cell
  intersection of: Restriction
    on property: has part
    some values from: CP_0000028
  intersection of: Restriction
    on property: has part
    some values from: CP_0000037
  intersection of: Restriction
    on property: has part
    some values from: GO_0005730
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0002505
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001945
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
subclass of: erythroid lineage cell
subclass of: nucleate cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: basophilic cytoplasm
subclass of: Restriction
  on property: has part
  some values from: GO_0005730
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001004
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001012
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001024
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001083
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001084
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001839
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001889
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002978
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0040072
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001945
subclass of: Restriction
  on property: develops from
  some values from: erythroid progenitor cell
textual definition: An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: FMA:83518
has_exact_synonym: rubriblast
has_obo_namespace: cell
has_related_synonym: pronormoblast
in subset: blood and immune upper slim
in subset: cellxgene subset

animal cell
type: Class
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: only in taxon
    some values from: NCBITaxon_33208
subclass of: eukaryotic cell
subclass of: Restriction
  on property: only in taxon
  some values from: NCBITaxon_33208
imported from: mondo.owl
has_obo_namespace: cell
in subset: upper level

basophilic erythroblast
type: Class
equivalent class: Class
  intersection of: erythroblast
  intersection of: Restriction
    on property: has part
    some values from: basophilic cytoplasm
  intersection of: Restriction
    on property: has part
    some values from: GO_0000792
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001945
equivalent class: Class
  intersection of: erythroblast
  intersection of: Restriction
    on property: has part
    some values from: CP_0000028
  intersection of: Restriction
    on property: has part
    some values from: GO_0000792
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001945
subclass of: erythroblast
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: basophilic cytoplasm
subclass of: Restriction
  on property: has part
  some values from: GO_0000792
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001945
subclass of: Restriction
  on property: develops from
  some values from: proerythroblast
textual definition: A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: FMA:83505
has_exact_synonym: basophilic normoblast
has_exact_synonym: early erythroblast
has_exact_synonym: early normoblast
has_exact_synonym: prorubricyte
has_obo_namespace: cell

polychromatophilic erythroblast
type: Class
equivalent class: Class
  intersection of: erythroblast
  intersection of: Restriction
    on property: has part
    some values from: polychromatophilic cytoplasm
  intersection of: Restriction
    on property: has part
    some values from: GO_0000792
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001945
equivalent class: Class
  intersection of: erythroblast
  intersection of: Restriction
    on property: has part
    some values from: CP_0000035
  intersection of: Restriction
    on property: has part
    some values from: GO_0000792
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001945
subclass of: erythroblast
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: polychromatophilic cytoplasm
subclass of: Restriction
  on property: has part
  some values from: GO_0000792
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001945
subclass of: Restriction
  on property: develops from
  some values from: basophilic erythroblast
textual definition: A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: FMA:83506
has_exact_synonym: intermediate erythroblast
has_exact_synonym: intermediate normoblast
has_exact_synonym: polychromatic erythroblast
has_exact_synonym: polychromatic normoblast
has_exact_synonym: polychromatophilic normoblast
has_exact_synonym: rubricyte
has_obo_namespace: cell

orthochromatic erythroblast
type: Class
equivalent class: Class
  intersection of: erythroblast
  intersection of: Restriction
    on property: has part
    some values from: acidophilic cytoplasm
  intersection of: Restriction
    on property: participates in
    some values from: GO_0030263
equivalent class: Class
  intersection of: erythroblast
  intersection of: Restriction
    on property: has part
    some values from: CP_0000027
  intersection of: Restriction
    on property: participates in
    some values from: GO_0030263
subclass of: erythroblast
subclass of: Restriction
  on property: has part
  some values from: acidophilic cytoplasm
subclass of: Restriction
  on property: participates in
  some values from: GO_0030263
subclass of: Restriction
  on property: develops from
  some values from: polychromatophilic erythroblast
textual definition: The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: FMA:84646
has_exact_synonym: acidophilic erythroblast
has_exact_synonym: eosinophilic erythroblast
has_exact_synonym: late erythoblast
has_exact_synonym: orthochromatic normoblast
has_exact_synonym: pyknotic eto enrythroblast
has_obo_namespace: cell

megakaryocyte progenitor cell
type: Class
equivalent class: Class
  intersection of: myeloid lineage restricted progenitor cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002981
  intersection of: Restriction
    on property: capable of
    some values from: GO_0007113
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030219
equivalent class: Class
  intersection of: myeloid lineage restricted progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0007113
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030219
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002981
subclass of: myeloid cell
subclass of: myeloid lineage restricted progenitor cell
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001004
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001012
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001024
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001083
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001084
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001839
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001889
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002978
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002981
subclass of: Restriction
  on property: develops from
  some values from: megakaryocyte-erythroid progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0007113
subclass of: Restriction
  on property: capable of
  some values from: GO_0030219
textual definition: The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0001164
database_cross_reference: CALOHA:TS-0610
database_cross_reference: FMA:84235
database_cross_reference: MESH:D055016
has_exact_synonym: CFU-Meg
has_exact_synonym: Meg-CFC
has_exact_synonym: MkP
has_exact_synonym: colony-forming unit-megakaryocyte
has_exact_synonym: megacaryoblast
has_exact_synonym: megacaryocyte progenitor cell
has_exact_synonym: megakaryoblast
has_exact_synonym: megakaryocytic progenitor cell
has_obo_namespace: cell
has_related_synonym: promegacaryocyte
has_related_synonym: promegakaryocyte
in subset: cellxgene subset
in subset: human reference atlas
comment: Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.

megakaryocyte
type: Class
equivalent class: Class
  intersection of: myeloid cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002371
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001393
subclass of: myeloid cell
subclass of: bone marrow hematopoietic cell
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0001393
subclass of: Restriction
  on property: develops from
  some values from: megakaryocyte progenitor cell
textual definition: A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm.
textual definition: A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000843
database_cross_reference: CALOHA:TS-0611
database_cross_reference: FMA:83555
has_exact_synonym: megacaryocyte
has_exact_synonym: megalocaryocyte
has_exact_synonym: megalokaryocyte
has_obo_namespace: cell
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: human reference atlas
comment: Megakaryocytes are reportedly CD181-positive and CD182-positive.

granulocyte monocyte progenitor cell
type: Class
equivalent class: Class
  intersection of: hematopoietic oligopotent progenitor cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002371
  intersection of: Restriction
    on property: has part
    some values from: PR_000001944
  intersection of: Restriction
    on property: has part
    some values from: PR_000005307
  intersection of: Restriction
    on property: lacks_part
    some values from: PR_000007857
  intersection of: Restriction
    on property: lacks_part
    some values from: PR_000007858
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001865
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030225
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030851
equivalent class: Class
  intersection of: hematopoietic oligopotent progenitor cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002371
  intersection of: Restriction
    on property: has part
    some values from: PR_000001944
  intersection of: Restriction
    on property: has part
    some values from: PR_000005307
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001865
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030225
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030851
  intersection of: Restriction
    on property: lacks_part
    some values from: PR_000007857
  intersection of: Restriction
    on property: lacks_part
    some values from: PR_000007858
subclass of: myeloid cell
subclass of: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
subclass of: hematopoietic oligopotent progenitor cell
subclass of: progenitor cell
subclass of: bone marrow hematopoietic cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: PR_000001944
subclass of: Restriction
  on property: has part
  some values from: PR_000005307
subclass of: Restriction
  on property: lacks_part
  some values from: PR_000007857
subclass of: Restriction
  on property: lacks_part
  some values from: PR_000007858
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001865
subclass of: Restriction
  on property: develops from
  some values from: common myeloid progenitor
subclass of: Restriction
  on property: capable of
  some values from: GO_0030225
subclass of: Restriction
  on property: capable of
  some values from: GO_0030851
textual definition: A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: CFU-C , Colony forming unit in culture
has_exact_synonym: CFU-GM
has_exact_synonym: GMP
has_exact_synonym: colony forming unit granulocyte macrophage
has_exact_synonym: granulocyte-macrophage progenitor
has_exact_synonym: granulocyte/monocyte precursor
has_exact_synonym: granulocyte/monocyte progenitor
has_obo_namespace: cell
has_related_synonym: CFU-GM
has_related_synonym: GMP
in subset: cellxgene subset
in subset: human reference atlas
comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.

reticulocyte
type: Class
equivalent class: Class
  intersection of: erythroid lineage cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001945
  intersection of: Restriction
    on property: capable of
    some values from: GO_0071971
equivalent class: Class
  intersection of: erythroid lineage cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001945
  intersection of: Restriction
    on property: capable of
    some values from: GO_0071971
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
subclass of: erythroid lineage cell
subclass of: PR_000050567
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001004
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001012
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001024
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001083
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001084
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001839
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001889
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002978
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001945
subclass of: Restriction
  on property: develops from
  some values from: orthochromatic erythroblast
subclass of: Restriction
  on property: capable of
  some values from: GO_0071971
textual definition: An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BTO:0001173
database_cross_reference: CALOHA:TS-0864
database_cross_reference: MESH:D012156
has_obo_namespace: cell
in subset: blood and immune upper slim
in subset: cellxgene subset

promonocyte
type: Class
equivalent class: Class
  intersection of: monopoietic cell
  intersection of: Restriction
    on property: has part
    some values from: GO_0042582
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001012
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030224
subclass of: myeloid cell
subclass of: monopoietic cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: GO_0042582
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001012
subclass of: Restriction
  on property: develops from
  some values from: monoblast
textual definition: A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0004657
database_cross_reference: FMA:83551
has_obo_namespace: cell
in subset: cellxgene subset
in subset: human reference atlas
comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid.

angioblastic mesenchymal cell
type: Class
equivalent class: Class
  intersection of: mesenchymal stem cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001444
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000002112
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000016043
subclass of: mesenchymal stem cell
subclass of: progenitor cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001444
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000002112
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000016043
subclass of: Restriction
  on property: develops from
  some values from: mesenchymal stem cell
textual definition: A mesenchymal stem cell capable of developing into blood vessel endothelium.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_exact_synonym: angioblast
has_exact_synonym: chondroplast
has_obo_namespace: cell
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive.

monocyte
type: Class
equivalent class: Class
  intersection of: myeloid leukocyte
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001407
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030225
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030316
  intersection of: Restriction
    on property: capable of
    some values from: GO_0043011
subclass of: mononuclear phagocyte
subclass of: myeloid leukocyte
subclass of: mononuclear cell
subclass of: progenitor cell
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000712
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000002214
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000003122
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000003683
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000010288
subclass of: Restriction
  on property: develops from
  some values from: promonocyte
subclass of: Restriction
  on property: capable of
  some values from: GO_0030225
subclass of: Restriction
  on property: capable of
  some values from: GO_0030316
subclass of: Restriction
  on property: capable of
  some values from: GO_0043011
textual definition: Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000876
database_cross_reference: CALOHA:TS-0638
database_cross_reference: FMA:62864
has_obo_namespace: cell
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas
comment: Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid.

experimentally modified cell in vitro
type: Class
subclass of: cell
subclass of: OBI_0000047
subclass of: Restriction
  on property: is_specified_output_of
  some values from: OBI_0000094
editor preferred label: experimentally modified cell in vitro
textual definition: A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure.
imported from: cl.owl
imported from: obi.owl

germ cell
type: Class
subclass of: germ line cell
subclass of: Restriction
  on property: capable of part of
  some values from: GO_0009566
textual definition: The reproductive cell in multicellular organisms.
imported from: cl.owl
imported from: hp.owl
database_cross_reference: BTO:0000535
database_cross_reference: NCIT:C12597
database_cross_reference: VHOG:0001534
database_cross_reference: WBbt:0006796
in subset: cellxgene subset

natural killer cell
type: Class
equivalent class: Class
  intersection of: group 1 innate lymphoid cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002228
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050776
subclass of: group 1 innate lymphoid cell
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001889
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000864
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000003001
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000004818
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000010578
subclass of: Restriction
  on property: develops from
  some values from: pro-NK cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0002228
subclass of: Restriction
  on property: capable of
  some values from: GO_0050776
textual definition: A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: large granular lymphocyte
has_broad_synonym: null cell
database_cross_reference: BTO:0000914
database_cross_reference: BTO:0004716
database_cross_reference: CALOHA:TS-0664
database_cross_reference: FMA:63147
database_cross_reference: FMA:83601
database_cross_reference: MESH:D007694
database_cross_reference: VHOG:0001697
has_exact_synonym: NK cell
in subset: cellxgene subset
in subset: general cell types upper slim
in subset: human reference atlas

supporting cell
type: Class
subclass of: cell
subclass of: native cell
textual definition: A cell whose primary function is to support other cell types.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BTO:0002315
has_exact_synonym: supportive cell
has_obo_namespace: cell
in subset: cellxgene subset
label: supportive cell

kidney granular cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002113
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002001
subclass of: protein secreting cell
subclass of: smooth muscle cell
subclass of: juxtaglomerular complex cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0002001
textual definition: A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: juxtaglomerular cell
database_cross_reference: FMA:84138
has_exact_synonym: JG cell
has_exact_synonym: renin secreting cell
in subset: human reference atlas

mesangial cell
type: Class
subclass of: pericyte
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000005159
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000006091
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000008516
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000010631
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000063895
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000171024
subclass of: Restriction
  on property: develops from
  some values from: mesenchymal stem cell
textual definition: A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries.
imported from: cl.owl
imported from: hp.owl
database_cross_reference: BTO:0000853
database_cross_reference: CALOHA:TS-0617
database_cross_reference: FMA:70972
database_cross_reference: MESH:D050527
has_exact_synonym: kidney mesangial cell
in subset: cellxgene subset
comment: Do all of these cells really develop from some mesenchymal stem cell?

podocyte
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005751
subclass of: renal filtration cell
subclass of: epithelial cell of glomerular capsule
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005751
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000004868
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000005420
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000007827
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000374462
textual definition: A specialized kidney epithelial cell, contained within a glomerulus, that contains "feet" that interdigitate with the "feet" of other podocytes.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: epithelial cell of visceral layer of glomerular capsule
database_cross_reference: BTO:0002295
database_cross_reference: FMA:70967
has_exact_synonym: glomerular podocyte
has_exact_synonym: glomerular visceral epithelial cell
has_exact_synonym: kidney podocyte
has_exact_synonym: renal podocyte
in subset: cellxgene subset
in subset: human reference atlas

fenestrated cell
type: Class
subclass of: epithelial cell
imported from: cl.owl
has_exact_synonym: window cell
in subset: cellxgene subset

pericyte
type: Class
subclass of: contractile cell
subclass of: supporting cell
subclass of: connective tissue cell
subclass of: mural cell
textual definition: An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_alternative_id: CL:0000184
database_cross_reference: BTO:0002441
database_cross_reference: FMA:63174
has_exact_synonym: ARC
has_exact_synonym: adventitial reticular cell
has_exact_synonym: cell of Rouget
has_exact_synonym: pericyte
has_exact_synonym: pericyte cell
has_exact_synonym: pericyte of Rouget
has_obo_namespace: cell
has_related_synonym: adventitial cell
in subset: cellxgene subset
in subset: human reference atlas
comment: Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A.
label: pericyte cell

muscle precursor cell
type: Class
equivalent class: Class
  intersection of: precursor cell
  intersection of: Restriction
    on property: develops into
    some values from: muscle cell
subclass of: non-terminally differentiated cell
subclass of: somatic cell
subclass of: Restriction
  on property: develops from
  some values from: mesodermal cell
subclass of: Restriction
  on property: develops into
  some values from: muscle cell
textual definition: A non-terminally differentiated cell that is capable of developing into a muscle cell.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
has_obo_namespace: cell
in subset: cellxgene subset

somatic stem cell
type: Class
equivalent class: Class
  intersection of: stem cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0048103
subclass of: stem cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0048103
textual definition: A stem cell that can give rise to cell types of the body other than those of the germ-line.
imported from: cl.owl
imported from: hp.owl
database_cross_reference: CALOHA:TS-2086
database_cross_reference: MESH:D053687

urothelial cell
type: Class
equivalent class: Class
  intersection of: transitional epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0000365
subclass of: transitional epithelial cell
subclass of: somatic cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000365
textual definition: A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria.
textual definition: A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria.
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: FMA:84127
has_narrow_synonym: bladder transitional cell
has_narrow_synonym: transitional epithelial cell of urinary bladder
has_narrow_synonym: urinary tract transitional epithelial cell
has_obo_namespace: cell
in subset: cellxgene subset

leukocyte
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0002505
  intersection of: Restriction
    on property: capable of
    some values from: GO_0001667
subclass of: motile cell
subclass of: eukaryotic cell
subclass of: hematopoietic cell
subclass of: nucleate cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002405
subclass of: Restriction
  on property: only in taxon
  some values from: NCBITaxon 7742
subclass of: Restriction
  on property: develops from
  some values from: hematopoietic stem cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0001667
textual definition: An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000751
database_cross_reference: CALOHA:TS-0549
database_cross_reference: FMA:62852
database_cross_reference: MESH:D007962
database_cross_reference: NCIT:C12529
has_exact_synonym: immune cell
has_exact_synonym: leucocyte
has_exact_synonym: white blood cell
has_obo_namespace: cell
has_related_synonym: immune cell
in subset: cellxgene subset
in subset: human reference atlas

myeloid cell
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: develops from
    some values from: common myeloid progenitor
subclass of: hematopoietic cell
subclass of: Restriction
  on property: develops from
  some values from: common myeloid progenitor
textual definition: A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BTO:0001441
database_cross_reference: CALOHA:TS-0647
database_cross_reference: MESH:D022423
has_obo_namespace: cell
in subset: cellxgene subset

erythroid lineage cell
type: Class
subclass of: myeloid cell
textual definition: A immature or mature cell in the lineage leading to and including erythrocytes.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_alternative_id: CL:0002156
database_cross_reference: CALOHA:TS-0290
database_cross_reference: FMA:62845
database_cross_reference: FMA:83516
has_exact_synonym: erythropoietic cell
has_obo_namespace: cell
in subset: cellxgene subset
in subset: human reference atlas
comment: Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes.

erythroblast
type: Class
equivalent class: Class
  intersection of: erythroid lineage cell
  intersection of: Restriction
    on property: has part
    some values from: GO_0005634
  intersection of: Restriction
    on property: lacks_part
    some values from: GO_0005730
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030218
equivalent class: Class
  intersection of: erythroid lineage cell
  intersection of: Restriction
    on property: has part
    some values from: GO_0005634
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030218
  intersection of: Restriction
    on property: lacks_part
    some values from: GO_0005730
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
subclass of: erythroid lineage cell
subclass of: progenitor cell
subclass of: Restriction
  on property: has part
  some values from: GO_0005634
subclass of: Restriction
  on property: lacks_part
  some values from: GO_0005730
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001004
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001012
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001024
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001083
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001084
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001839
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001889
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002978
subclass of: Restriction
  on property: develops from
  some values from: proerythroblast
subclass of: Restriction
  on property: capable of
  some values from: GO_0030218
textual definition: A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BTO:0001571
database_cross_reference: CALOHA:TS-0289
database_cross_reference: FMA:83504
database_cross_reference: MESH:D004900
has_exact_synonym: normoblast
has_obo_namespace: cell
in subset: blood and immune upper slim
in subset: cellxgene subset

myeloid leukocyte
type: Class
equivalent class: Class
  intersection of: leukocyte
  intersection of: Restriction
    on property: develops from
    some values from: common myeloid progenitor
subclass of: leukocyte
subclass of: myeloid cell
textual definition: A cell of the monocyte, granulocyte, or mast cell lineage.
imported from: cl.owl
imported from: mondo.owl
has_obo_namespace: cell
in subset: cellxgene subset

basophil
type: Class
equivalent class: Class
  intersection of: granulocyte
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001344
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001950
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000001255
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000001865
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000007431
subclass of: granulocyte
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001344
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001950
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000001255
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000001865
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000007431
textual definition: Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: polymorphonuclear leucocyte
has_broad_synonym: polymorphonuclear leukocyte
database_cross_reference: BTO:0000129
database_cross_reference: CALOHA:TS-0073
database_cross_reference: FMA:62862
has_exact_synonym: basophilic leucocyte
has_exact_synonym: basophilic leukocyte
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: human reference atlas
comment: Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive.

neutrophil
type: Class
equivalent class: Class
  intersection of: granulocyte
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001479
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001879
subclass of: granulocyte
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000001441
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000002215
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000006279
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000006280
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001479
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001879
textual definition: Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: PMN
has_broad_synonym: poly
has_broad_synonym: polymorphonuclear leucocyte
has_broad_synonym: polymorphonuclear leukocyte
has_broad_synonym: polymorphonuclear neutrophil
has_broad_synonym: polynuclear neutrophilic leucocyte
has_broad_synonym: polynuclear neutrophilic leukocyte
database_cross_reference: BTO:0000130
database_cross_reference: CALOHA:TS-0688
database_cross_reference: FMA:62860
database_cross_reference: MESH:D009504
has_exact_synonym: neutrocyte
has_exact_synonym: neutrophil leucocyte
has_exact_synonym: neutrophil leukocyte
has_exact_synonym: neutrophilic leucocyte
has_exact_synonym: neutrophilic leukocyte
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: human reference atlas

myeloid dendritic cell
type: Class
equivalent class: Class
  intersection of: conventional dendritic cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001865
  intersection of: Restriction
    on property: develops from
    some values from: myeloid cell
subclass of: myeloid leukocyte
subclass of: conventional dendritic cell
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001865
subclass of: Restriction
  on property: develops from
  some values from: myeloid cell
textual definition: A dendritic cell of the myeloid lineage.
imported from: cl.owl
has_broad_synonym: interdigitating cell
has_broad_synonym: veiled cell
database_cross_reference: BTO:0004721
has_exact_synonym: CD11c+CD123- DC
has_exact_synonym: mDC
in subset: cellxgene subset
comment: These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8).

mature B cell
type: Class
equivalent class: Class
  intersection of: B cell, CD19-positive
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002504
  intersection of: Restriction
    on property: capable of
    some values from: GO_0042113
  intersection of: Restriction
    on property: output of
    some values from: GO_0002335
equivalent class: Class
  intersection of: B cell, CD19-positive
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002504
  intersection of: Restriction
    on property: capable of
    some values from: GO_0042113
  intersection of: Restriction
    on property: has_completed
    some values from: GO_0002335
subclass of: professional antigen presenting cell
subclass of: B cell, CD19-positive
subclass of: Restriction
  on property: develops from
  some values from: transitional stage B cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0042113
subclass of: Restriction
  on property: output of
  some values from: GO_0002335
textual definition: A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen.
imported from: cl.owl
imported from: mondo.owl
has_exact_synonym: mature B lymphocyte
has_exact_synonym: mature B-cell
has_exact_synonym: mature B-lymphocyte
has_obo_namespace: cell
in subset: cellxgene subset
comment: Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive.

plasma cell
type: Class
equivalent class: Class
  intersection of: antibody secreting cell
  intersection of: Restriction
    on property: has part
    some values from: cartwheel heterochromatin
  intersection of: Restriction
    on property: has part
    some values from: GO_0005794
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0019814
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0042613
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001935
equivalent class: Class
  intersection of: antibody secreting cell
  intersection of: Restriction
    on property: has part
    some values from: CP_0000043
  intersection of: Restriction
    on property: has part
    some values from: GO_0005794
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001935
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0019814
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0042613
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
subclass of: antibody secreting cell
subclass of: Restriction
  on property: has part
  some values from: cartwheel heterochromatin
subclass of: Restriction
  on property: has part
  some values from: GO_0005794
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: GO_0019814
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: GO_0042613
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000952
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000003512
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000003514
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000051237
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000083416
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001935
subclass of: Restriction
  on property: develops from
  some values from: plasmablast
textual definition: A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000392
database_cross_reference: FMA:70574
database_cross_reference: MESH:D010950
has_exact_synonym: plasma B cell
has_exact_synonym: plasma B-cell
has_exact_synonym: plasmacyte
has_exact_synonym: plasmocyte
has_obo_namespace: cell
has_related_synonym: effector B cell
has_related_synonym: effector B-cell
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: human reference atlas
comment: Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive.

alpha-beta T cell
type: Class
equivalent class: Class
  intersection of: T cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: GO_0042105
subclass of: T cell
subclass of: Restriction
  on property: has plasma membrane part
  some values from: GO_0042105
textual definition: A T cell that expresses an alpha-beta T cell receptor complex.
imported from: cl.owl
has_exact_synonym: alpha-beta T lymphocyte
has_exact_synonym: alpha-beta T-cell
has_exact_synonym: alpha-beta T-lymphocyte
in subset: blood and immune upper slim
in subset: cellxgene subset

immature alpha-beta T cell
type: Class
equivalent class: Class
  intersection of: alpha-beta T cell
  intersection of: Restriction
    on property: has_not_completed
    some values from: GO_0045058
subclass of: alpha-beta T cell
subclass of: immature T cell
textual definition: An alpha-beta T cell that has an immature phenotype and has not completed T cell selection.
imported from: cl.owl
has_exact_synonym: immature alpha-beta T lymphocyte
has_exact_synonym: immature alpha-beta T-cell
has_exact_synonym: immature alpha-beta T-lymphocyte
in subset: cellxgene subset

mature alpha-beta T cell
type: Class
equivalent class: Class
  intersection of: alpha-beta T cell
  intersection of: Restriction
    on property: output of
    some values from: GO_0045058
subclass of: alpha-beta T cell
subclass of: mature T cell
subclass of: Restriction
  on property: develops from
  some values from: immature alpha-beta T cell
textual definition: A alpha-beta T cell that has a mature phenotype.
imported from: cl.owl
has_exact_synonym: mature alpha-beta T lymphocyte
has_exact_synonym: mature alpha-beta T-cell
has_exact_synonym: mature alpha-beta T-lymphocyte
in subset: cellxgene subset

immature single positive thymocyte
type: Class
equivalent class: Class
  intersection of: thymocyte
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001307
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001380
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: GO_0043384
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000025402
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000001932
subclass of: thymocyte
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001004
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001307
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001380
subclass of: Restriction
  on property: has plasma membrane part
  some values from: GO_0043384
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000025402
subclass of: Restriction
  on property: develops from
  some values from: DN4 thymocyte
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000001932
textual definition: A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive.
imported from: cl.owl
has_exact_synonym: ISP
has_exact_synonym: T.ISP.th
has_exact_synonym: immature single positive T cell
has_exact_synonym: immature single positive T lymphocyte
has_exact_synonym: immature single positive T-lymphocyte
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages.

DN2 thymocyte
type: Class
equivalent class: Class
  intersection of: thymocyte
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000025402
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001307
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001380
subclass of: double negative thymocyte
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001307
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001380
subclass of: Restriction
  on property: develops from
  some values from: DN1 thymic pro-T cell
textual definition: A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive.
imported from: cl.owl
has_exact_synonym: DN2 alpha-beta immature T lymphocyte
has_exact_synonym: DN2 alpha-beta immature T-cell
has_exact_synonym: DN2 alpha-beta immature T-lymphocyte
has_exact_synonym: DN2 cell
has_exact_synonym: DN2 immature T cell
has_exact_synonym: TN2 cell
has_exact_synonym: TN2 thymocyte
has_exact_synonym: double negative 2
has_exact_synonym: preT.DN2.Th
comment: Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. Also, there is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.

DN3 thymocyte
type: Class
equivalent class: Class
  intersection of: thymocyte
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001307
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000025402
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: GO_0043384
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001380
subclass of: double negative thymocyte
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001307
subclass of: Restriction
  on property: has plasma membrane part
  some values from: GO_0043384
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001380
subclass of: Restriction
  on property: develops from
  some values from: DN2 thymocyte
textual definition: A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain.
imported from: cl.owl
has_broad_synonym: early cortical thymocyte
has_exact_synonym: DN3 alpha-beta immature T lymphocyte
has_exact_synonym: DN3 alpha-beta immature T-cell
has_exact_synonym: DN3 alpha-beta immature T-lymphocyte
has_exact_synonym: DN3 cell
has_exact_synonym: DN3 immature T cell
has_exact_synonym: TN3 cell
has_exact_synonym: TN3 thymocyte
has_exact_synonym: double negative 3
has_exact_synonym: preT.DN3.Th
in subset: cellxgene subset
comment: There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.

DN4 thymocyte
type: Class
equivalent class: Class
  intersection of: thymocyte
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001307
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001380
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000025402
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: GO_0043384
subclass of: double negative thymocyte
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001307
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001380
subclass of: Restriction
  on property: has plasma membrane part
  some values from: GO_0043384
subclass of: Restriction
  on property: develops from
  some values from: DN3 thymocyte
textual definition: A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive.
imported from: cl.owl
has_broad_synonym: early cortical thymocyte
has_exact_synonym: DN4 alpha-beta immature T lymphocyte
has_exact_synonym: DN4 alpha-beta immature T-lymphocyte
has_exact_synonym: DN4 cell
has_exact_synonym: DN4 immature T cell
has_exact_synonym: DN4 immature T-cell
has_exact_synonym: T.DN4.th
has_exact_synonym: double negative 4
in subset: cellxgene subset
comment: Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.

double-positive, alpha-beta thymocyte
type: Class
equivalent class: Class
  intersection of: immature alpha-beta T cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002370
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001004
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000025402
subclass of: immature alpha-beta T cell
subclass of: thymocyte
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001004
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000025402
subclass of: Restriction
  on property: develops from
  some values from: immature single positive thymocyte
textual definition: A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: late cortical thymocyte
has_exact_synonym: DP cell
has_exact_synonym: DP thymocyte
has_exact_synonym: double-positive, alpha-beta immature T lymphocyte
in subset: cellxgene subset
in subset: human reference atlas
comment: Thymocytes of this stage are undergoing positive and negative selection.

mature NK T cell
type: Class
equivalent class: Class
  intersection of: mature alpha-beta T cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001874
  intersection of: Restriction
    on property: capable of
    some values from: GO_0032394
  intersection of: Restriction
    on property: capable of
    some values from: GO_0045087
  intersection of: Restriction
    on property: output of
    some values from: GO_0030217
subclass of: mature alpha-beta T cell
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000864
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000919
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000003001
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000004818
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000010225
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000010578
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001874
subclass of: Restriction
  on property: develops from
  some values from: immature NK T cell stage IV
subclass of: Restriction
  on property: capable of
  some values from: GO_0032394
subclass of: Restriction
  on property: capable of
  some values from: GO_0045087
subclass of: Restriction
  on property: output of
  some values from: GO_0030217
textual definition: A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_exact_synonym: mature NK T lymphocyte
has_exact_synonym: mature NK T-cell
has_exact_synonym: mature NK T-lymphocyte
has_exact_synonym: mature NKT cell
has_exact_synonym: mature natural killer T cell
has_exact_synonym: mature natural killer T lymphocyte
has_exact_synonym: mature natural killer T-cell
has_exact_synonym: mature natural killer T-lymphocyte
in subset: cellxgene subset
in subset: human reference atlas

immature B cell
type: Class
equivalent class: Class
  intersection of: B cell, CD19-positive
  intersection of: Restriction
    on property: has_not_completed
    some values from: GO_0045190
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0071738
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: GO_0071753
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001289
equivalent class: Class
  intersection of: B cell, CD19-positive
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: GO_0071753
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001289
  intersection of: Restriction
    on property: has_not_completed
    some values from: GO_0045190
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0071738
subclass of: B cell, CD19-positive
subclass of: Restriction
  on property: has_not_completed
  some values from: GO_0045190
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: GO_0071738
subclass of: Restriction
  on property: has plasma membrane part
  some values from: GO_0071753
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001289
subclass of: Restriction
  on property: develops from
  some values from: small pre-B-II cell
textual definition: An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_exact_synonym: immature B lymphocyte
has_exact_synonym: immature B-cell
has_exact_synonym: immature B-lymphocyte
has_exact_synonym: newly formed B cell
has_obo_namespace: cell
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: human reference atlas
comment: Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive.

precursor B cell
type: Class
equivalent class: Class
  intersection of: B cell, CD19-positive
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0071753
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001898
equivalent class: Class
  intersection of: B cell, CD19-positive
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001898
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0071753
subclass of: B cell, CD19-positive
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: GO_0071753
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001898
textual definition: A precursor B cell is a B cell with the phenotype CD10-positive.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0001133
database_cross_reference: CALOHA:TS-0819
has_obo_namespace: cell
has_related_synonym: pre-B cell
in subset: cellxgene subset
in subset: human reference atlas

transitional stage B cell
type: Class
equivalent class: Class
  intersection of: B cell, CD19-positive
  intersection of: Restriction
    on property: has_not_completed
    some values from: GO_0002335
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: GO_0071753
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001289
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000001408
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000001932
equivalent class: Class
  intersection of: B cell, CD19-positive
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: GO_0071753
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001289
  intersection of: Restriction
    on property: has_high_plasma_membrane_amount
    some values from: PR_000001408
  intersection of: Restriction
    on property: has_high_plasma_membrane_amount
    some values from: PR_000001932
  intersection of: Restriction
    on property: has_not_completed
    some values from: GO_0002335
subclass of: B cell, CD19-positive
subclass of: Restriction
  on property: has_not_completed
  some values from: GO_0002335
subclass of: Restriction
  on property: has plasma membrane part
  some values from: GO_0071753
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001289
subclass of: Restriction
  on property: develops from
  some values from: immature B cell
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000001408
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000001932
textual definition: An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_exact_synonym: transitional B cell
has_exact_synonym: transitional stage B lymphocyte
has_exact_synonym: transitional stage B-cell
has_exact_synonym: transitional stage B-lymphocyte
has_narrow_synonym: T1 B cell
has_narrow_synonym: T2 B cell
has_narrow_synonym: T3 B cell
has_obo_namespace: cell
in subset: cellxgene subset
in subset: human reference atlas
comment: This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'.

pro-NK cell
type: Class
equivalent class: Class
  intersection of: lymphoid lineage restricted progenitor cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001874
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002065
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001003
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001015
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001381
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001898
subclass of: lymphoid lineage restricted progenitor cell
subclass of: PR_000050567
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001874
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002065
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001003
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001015
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001381
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001898
subclass of: Restriction
  on property: develops from
  some values from: common lymphoid progenitor
textual definition: A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative.
imported from: cl.owl
has_exact_synonym: NKP
has_exact_synonym: natural killer cell progenitor
has_exact_synonym: pro-natural killer cell
has_related_synonym: null cell
has_related_synonym: preNK cell
comment: Most markers only described for human pro NK cells.

pro-B cell
type: Class
equivalent class: Class
  intersection of: lymphoid lineage restricted progenitor cell
  intersection of: Restriction
    on property: has part
    some values from: PR_000001903
  intersection of: Restriction
    on property: has part
    some values from: PR_000006611
  intersection of: Restriction
    on property: participates in
    some values from: GO_0033152
subclass of: lymphoid lineage restricted progenitor cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: PR_000001903
subclass of: Restriction
  on property: has part
  some values from: PR_000006611
subclass of: Restriction
  on property: participates in
  some values from: GO_0033152
subclass of: Restriction
  on property: develops from
  some values from: common lymphoid progenitor
textual definition: A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: pre-pro B cell
database_cross_reference: BTO:0003104
has_exact_synonym: pro-B lymphocyte
has_exact_synonym: pro-B-cell
has_exact_synonym: pro-B-lymphocyte
has_exact_synonym: progenitor B cell
has_exact_synonym: progenitor B lymphocyte
has_exact_synonym: progenitor B-cell
has_exact_synonym: progenitor B-lymphocyte
has_obo_namespace: cell
has_related_synonym: pre-B cell (Philadelphia nomenclature)
in subset: cellxgene subset
in subset: human reference atlas
comment: Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.

pro-T cell
type: Class
equivalent class: Class
  intersection of: lymphoid lineage restricted progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030217
subclass of: lymphoid lineage restricted progenitor cell
subclass of: Restriction
  on property: develops from
  some values from: common lymphoid progenitor
subclass of: Restriction
  on property: capable of
  some values from: GO_0030217
textual definition: A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage.
imported from: cl.owl
has_exact_synonym: pro-T lymphocyte
has_exact_synonym: progenitor T cell
has_narrow_synonym: DN1 cell
has_narrow_synonym: DN1 thymocyte
has_narrow_synonym: TN1 cell
in subset: cellxgene subset

mast cell progenitor
type: Class
equivalent class: Class
  intersection of: myeloid lineage restricted progenitor cell
  intersection of: Restriction
    on property: has part
    some values from: PR_000007857
  intersection of: Restriction
    on property: has part
    some values from: PR_000007858
  intersection of: Restriction
    on property: lacks_part
    some values from: PR_000005307
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001963
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002979
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002980
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002981
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000005178
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000016401
  intersection of: Restriction
    on property: capable of
    some values from: GO_0060374
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000009143
  intersection of: Restriction
    on property: has low plasma membrane amount
    some values from: PR_000002065
  intersection of: Restriction
    on property: has low plasma membrane amount
    some values from: PR_000007431
subclass of: myeloid cell
subclass of: myeloid lineage restricted progenitor cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: PR_000007857
subclass of: Restriction
  on property: has part
  some values from: PR_000007858
subclass of: Restriction
  on property: lacks_part
  some values from: PR_000005307
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001004
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001012
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001024
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001083
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001084
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001839
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001889
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001963
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002978
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002979
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002980
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002981
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000005178
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000016401
subclass of: Restriction
  on property: develops from
  some values from: basophil mast progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0060374
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000009143
subclass of: Restriction
  on property: has low plasma membrane amount
  some values from: PR_000002065
subclass of: Restriction
  on property: has low plasma membrane amount
  some values from: PR_000007431
textual definition: A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative.
imported from: cl.owl
has_exact_synonym: MCP
has_related_synonym: CFU-MC
has_related_synonym: CFU-Mast
has_related_synonym: colony forming unit mast cell
comment: MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa.

hematopoietic multipotent progenitor cell
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001869
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002981
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001402
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001003
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001402
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001003
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001869
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002981
subclass of: hematopoietic cell
subclass of: hematopoietic precursor cell
subclass of: PR_000050567
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001004
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001012
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001024
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001083
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001084
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001839
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001869
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001889
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002978
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002981
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0001402
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001003
subclass of: Restriction
  on property: develops from
  some values from: hematopoietic stem cell
textual definition: A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0000725
database_cross_reference: CALOHA:TS-0448
has_exact_synonym: MPP
has_exact_synonym: hemopoietic progenitor cell
has_obo_namespace: cell
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: human reference atlas
comment: Markers differ between mouse and human.

lymphoid lineage restricted progenitor cell
type: Class
equivalent class: Class
  intersection of: hematopoietic lineage restricted progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030098
subclass of: hematopoietic lineage restricted progenitor cell
subclass of: progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030098
textual definition: A progenitor cell restricted to the lymphoid lineage.
imported from: cl.owl
imported from: mondo.owl
has_broad_synonym: lymphoid progenitor cell
database_cross_reference: BTO:0004731
database_cross_reference: CALOHA:TS-2025
database_cross_reference: FMA:70338
has_obo_namespace: cell
in subset: cellxgene subset
comment: Note that this is a class of cell types, not an identified single cell type.

myeloid lineage restricted progenitor cell
type: Class
equivalent class: Class
  intersection of: hematopoietic lineage restricted progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030099
subclass of: hematopoietic lineage restricted progenitor cell
subclass of: progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030099
textual definition: A progenitor cell restricted to the myeloid lineage.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: myeloid progenitor cell
database_cross_reference: BTO:0004730
database_cross_reference: CALOHA:TS-2099
database_cross_reference: FMA:70339
has_obo_namespace: cell
in subset: cellxgene subset
in subset: human reference atlas
comment: Note that this is a class of cell types, not an identified single cell type.

mononuclear cell
type: Class
equivalent class: Class
  intersection of: leukocyte
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001407
subclass of: single nucleate cell
subclass of: leukocyte
textual definition: A leukocyte with a single non-segmented nucleus in the mature form.
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: BTO:0000878
database_cross_reference: CALOHA:TS-0768
database_cross_reference: FMA:86713
has_exact_synonym: mononuclear leukocyte
has_narrow_synonym: peripheral blood mononuclear cell
has_obo_namespace: cell
in subset: blood and immune upper slim
in subset: cellxgene subset

classical monocyte
type: Class
equivalent class: Class
  intersection of: monocyte
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002548
  intersection of: Restriction
    on property: capable of
    some values from: GO_0006909
  intersection of: Restriction
    on property: capable of
    some values from: GO_0006954
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000001199
subclass of: monocyte
subclass of: PR_000050567
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: capable of
  some values from: GO_0002548
subclass of: Restriction
  on property: capable of
  some values from: GO_0006954
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000001199
textual definition: A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_exact_synonym: inflammatory monocyte
in subset: cellxgene subset
in subset: human reference atlas
comment: Markers: CCR2+CXCCR1<low> (human, mouse, rat).

elicited macrophage
type: Class
equivalent class: Class
  intersection of: macrophage
  intersection of: Restriction
    on property: participates in
    some values from: GO_0006954
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001012
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001813
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000002064
subclass of: macrophage
subclass of: PR_000050567
subclass of: Restriction
  on property: participates in
  some values from: GO_0006954
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001012
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001813
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000002064
subclass of: Restriction
  on property: develops from
  some values from: classical monocyte
textual definition: A macrophage which develops from an inflammatory monocyte and is recruited into the tissues in response to injury and infection as part of an inflammatory response. Markers include CD11b-positive, CD68-positive, and F4/80-positive.
imported from: cl.owl
database_cross_reference: FMA:84643
database_cross_reference: FMA:84645
has_exact_synonym: free macrophage
has_exact_synonym: wandering histiocyte
in subset: cellxgene subset
comment: Markers: CD11b+, CD68+; Mouse: F4/80+; role or process: immune, inflammation (inflammatory response).

suppressor macrophage
type: Class
equivalent class: Class
  intersection of: elicited macrophage
  intersection of: Restriction
    on property: capable of
    some values from: GO_0050777
subclass of: elicited macrophage
subclass of: Restriction
  on property: capable of
  some values from: GO_0050777
textual definition: A macrophage that suppresses immune responses.
imported from: cl.owl
comment: Markers: May express: IL10, TGFbeta.

inflammatory macrophage
type: Class
equivalent class: Class
  intersection of: elicited macrophage
  intersection of: Restriction
    on property: capable of
    some values from: GO_0032611
  intersection of: Restriction
    on property: capable of
    some values from: GO_0032635
  intersection of: Restriction
    on property: capable of
    some values from: GO_0032640
  intersection of: Restriction
    on property: capable of
    some values from: GO_0042554
  intersection of: Restriction
    on property: capable of
    some values from: GO_0042742
  intersection of: Restriction
    on property: capable of
    some values from: GO_0051767
subclass of: elicited macrophage
subclass of: Restriction
  on property: capable of
  some values from: GO_0032611
subclass of: Restriction
  on property: capable of
  some values from: GO_0032635
subclass of: Restriction
  on property: capable of
  some values from: GO_0032640
subclass of: Restriction
  on property: capable of
  some values from: GO_0042554
subclass of: Restriction
  on property: capable of
  some values from: GO_0042742
subclass of: Restriction
  on property: capable of
  some values from: GO_0051767
textual definition: An elicited macrophage that is recruited into the tissues in response to injury and infection as part of an inflammatory response, expresses high levels of pro-inflammatory cytokines, ROS and NO, and shows potent microbicidal activity.
imported from: cl.owl
has_exact_synonym: classically activated macrophage
has_related_synonym: M1 macrophage
in subset: cellxgene subset
comment: Markers: Express: TNFa, IL1b, IL6, iNOS, NADPH-oxidase; produce: reactive oxygen species, nitric oxide; role or process: immune, inflammation (inflammatory response).

tissue-resident macrophage
type: Class
equivalent class: Class
  intersection of: macrophage
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0000479
subclass of: macrophage
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000479
textual definition: A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: FMA:84642
database_cross_reference: FMA:84644
has_exact_synonym: fixed macrophage
has_exact_synonym: resting histiocyte
in subset: cellxgene subset
in subset: human reference atlas

alternatively activated macrophage
type: Class
equivalent class: Class
  intersection of: elicited macrophage
  intersection of: Restriction
    on property: has part
    some values from: PR_000001844
  intersection of: Restriction
    on property: capable of
    some values from: GO_0048771
subclass of: elicited macrophage
subclass of: Restriction
  on property: has part
  some values from: PR_000001844
subclass of: Restriction
  on property: capable of
  some values from: GO_0048771
textual definition: An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling.
imported from: cl.owl
has_related_synonym: M2 macrophage
in subset: cellxgene subset
comment: Role or process: tissue remodeling.

foam cell
type: Class
subclass of: cell
textual definition: A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions.
imported from: hp.owl
database_cross_reference: BTO:0003872
database_cross_reference: FMA:83586
database_cross_reference: MESH:D005487

thymocyte
type: Class
equivalent class: Class
  intersection of: T cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002370
  intersection of: Restriction
    on property: has_not_completed
    some values from: GO_0045058
subclass of: immature T cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002370
textual definition: An immature T cell located in the thymus.
imported from: cl.owl
has_broad_synonym: immature T cell
has_broad_synonym: immature T lymphocyte
has_broad_synonym: immature T-cell
has_broad_synonym: immature T-lymphocyte
database_cross_reference: BTO:0001372
database_cross_reference: CALOHA:TS-1042
database_cross_reference: FMA:72202
database_cross_reference: MESH:D060168
database_cross_reference: XAO:0003159
has_exact_synonym: thymic lymphocyte
in subset: cellxgene subset

DN1 thymic pro-T cell
type: Class
equivalent class: Class
  intersection of: pro-T cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002370
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001380
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001307
subclass of: pro-T cell
subclass of: PR_000050567
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002370
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001004
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001084
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001380
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001307
subclass of: Restriction
  on property: develops from
  some values from: early T lineage precursor
textual definition: A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative.
imported from: cl.owl
has_exact_synonym: DN1 thymic pro-T lymphocyte
has_exact_synonym: DN1 thymic pro-T-cell
has_exact_synonym: DN1 thymic pro-T-lymphocyte
has_exact_synonym: DN1 thymic progenitor T cell
has_exact_synonym: DN1 thymocyte
has_exact_synonym: double negative 1
has_exact_synonym: preT.DN1.Th
in subset: cellxgene subset

immature NK T cell
type: Class
equivalent class: Class
  intersection of: immature alpha-beta T cell
  intersection of: Restriction
    on property: has part
    some values from: PR_000003469
subclass of: immature alpha-beta T cell
subclass of: Restriction
  on property: has part
  some values from: PR_000003469
subclass of: Restriction
  on property: develops from
  some values from: double-positive, alpha-beta thymocyte
textual definition: An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_exact_synonym: immature NK T lymphocyte
has_exact_synonym: immature NK T-cell
has_exact_synonym: immature NK T-lymphocyte
has_exact_synonym: immature NKT cell
in subset: cellxgene subset
in subset: human reference atlas

lymphocyte of B lineage
type: Class
subclass of: lymphocyte
subclass of: Restriction
  on property: develops from
  some values from: pro-B cell
textual definition: A lymphocyte of B lineage with the commitment to express an immunoglobulin complex.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_obo_namespace: cell
in subset: human reference atlas
comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).

antibody secreting cell
type: Class
equivalent class: Class
  intersection of: lymphocyte of B lineage
  intersection of: Restriction
    on property: produces
    some values from: GO_0042571
subclass of: lymphocyte of B lineage
subclass of: Restriction
  on property: produces
  some values from: GO_0042571
textual definition: A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin.
imported from: cl.owl
imported from: mondo.owl
has_obo_namespace: cell

small pre-B-II cell
type: Class
equivalent class: Class
  intersection of: pre-B-II cell
  intersection of: Restriction
    on property: has part
    some values from: PR_000003457
  intersection of: Restriction
    on property: has part
    some values from: PR_000003460
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0019815
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0035369
  intersection of: Restriction
    on property: participates in
    some values from: GO_0071708
equivalent class: Class
  intersection of: pre-B-II cell
  intersection of: Restriction
    on property: has part
    some values from: PR_000003457
  intersection of: Restriction
    on property: has part
    some values from: PR_000003460
  intersection of: Restriction
    on property: participates in
    some values from: GO_0071708
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0019815
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: GO_0035369
subclass of: pre-B-II cell
subclass of: Restriction
  on property: has part
  some values from: PR_000003457
subclass of: Restriction
  on property: has part
  some values from: PR_000003460
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: GO_0019815
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: GO_0035369
subclass of: Restriction
  on property: participates in
  some values from: GO_0071708
textual definition: A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes.
imported from: cl.owl
imported from: mondo.owl
has_exact_synonym: small pre-BII cell
has_obo_namespace: cell
in subset: cellxgene subset
comment: Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.

pre-B-II cell
type: Class
equivalent class: Class
  intersection of: precursor B cell
  intersection of: Restriction
    on property: lacks_part
    some values from: PR_000006611
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001003
  intersection of: Restriction
    on property: output of
    some values from: GO_0071707
equivalent class: Class
  intersection of: precursor B cell
  intersection of: Restriction
    on property: has_completed
    some values from: GO_0071707
  intersection of: Restriction
    on property: lacks_part
    some values from: PR_000006611
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001003
subclass of: precursor B cell
subclass of: Restriction
  on property: lacks_part
  some values from: PR_000006611
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001003
subclass of: Restriction
  on property: develops from
  some values from: pro-B cell
subclass of: Restriction
  on property: output of
  some values from: GO_0071707
textual definition: A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain.
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: BTO:0001133
database_cross_reference: CALOHA:TS-0819
has_exact_synonym: pre-B-lymphocyte
has_exact_synonym: pre-BII cell
has_obo_namespace: cell
comment: pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive.

plasmablast
type: Class
equivalent class: Class
  intersection of: mature B cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001935
  intersection of: Restriction
    on property: produces
    some values from: GO_0042571
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000001408
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000001963
equivalent class: Class
  intersection of: mature B cell
  intersection of: Restriction
    on property: produces
    some values from: GO_0042571
  intersection of: Restriction
    on property: has_high_plasma_membrane_amount
    some values from: PR_000001408
  intersection of: Restriction
    on property: has_high_plasma_membrane_amount
    some values from: PR_000001963
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001935
subclass of: mature B cell
subclass of: antibody secreting cell
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001935
subclass of: Restriction
  on property: develops from
  some values from: mature B cell
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000001408
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000001963
textual definition: An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative.
imported from: cl.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: CD20-negative B cell
database_cross_reference: FMA:84371
has_exact_synonym: CD27-positive, CD38-positive, CD20-negative B cell
has_obo_namespace: cell
in subset: cellxgene subset
in subset: human reference atlas
comment: This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative.

hematopoietic cell
type: Class
subclass of: cell
subclass of: animal cell
subclass of: somatic cell
textual definition: A cell of a hematopoietic lineage.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
database_cross_reference: BTO:0000574
database_cross_reference: CALOHA:TS-2017
database_cross_reference: FMA:70366
database_cross_reference: FMA:83598
has_exact_synonym: haematopoietic cell
has_exact_synonym: haemopoietic cell
has_exact_synonym: hemopoietic cell
has_obo_namespace: cell
in subset: cellxgene subset

conventional dendritic cell
type: Class
equivalent class: Class
  intersection of: dendritic cell
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000001013
subclass of: dendritic cell
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000001013
textual definition: Conventional dendritic cell is a dendritic cell that is CD11c-high.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
has_broad_synonym: interdigitating cell
has_broad_synonym: veiled cell
database_cross_reference: FMA:84191
has_exact_synonym: DC1
has_exact_synonym: cDC
has_exact_synonym: dendritic reticular cell
has_exact_synonym: type 1 DC
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: human reference atlas
comment: Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive.

CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
type: Class
equivalent class: Class
  union of: CD34-positive, CD38-positive common lymphoid progenitor
  union of: CD34-positive, CD38-positive common myeloid progenitor
subclass of: hematopoietic oligopotent progenitor cell, lineage-negative
imported from: cl.owl
imported from: mondo.owl
has_broad_synonym: CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid
has_obo_namespace: cell
comment: Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617).

interstitial dendritic cell
type: Class
equivalent class: Class
  intersection of: conventional dendritic cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001012
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001300
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001905
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000002025
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000002972
subclass of: CD11b-positive dendritic cell
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001300
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001905
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000002025
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000002972
textual definition: Interstitial dendritic cell is a conventional dendritic cell that is CD11b-positive, CD1a-positive, CD206-positive, CD209-positive, and CD36-positive.
imported from: cl.owl
comment: Originally described in the dendritic cell ontology (DC_CL:0000020)(PMID:19243617). These cells are also CD281-positive (TLR1), CD282-positive (TLR2), CD283-positive (TLR3), CD284-positive (TLR4), CD286-positive (TLR6), CD288-positive (TLR8), and CD290-positive (TLR10).

CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
type: Class
equivalent class: Class
  union of: granulocyte monocyte progenitor cell
  union of: CD7-negative lymphoid progenitor cell
subclass of: hematopoietic oligopotent progenitor cell, lineage-negative
imported from: cl.owl
imported from: mondo.owl
has_obo_namespace: cell
comment: Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617).

CD34-positive, CD38-positive common lymphoid progenitor
type: Class
equivalent class: Class
  intersection of: common lymphoid progenitor
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001003
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001015
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001408
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001898
subclass of: common lymphoid progenitor
subclass of: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
subclass of: PR_000050567
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001003
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001015
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001408
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001898
subclass of: Restriction
  on property: develops from
  some values from: CD34-positive, CD38-negative multipotent progenitor cell
textual definition: A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive.
imported from: cl.owl
imported from: mondo.owl
has_exact_synonym: CD10-positive common lymphocyte precursor
has_exact_synonym: CD10-positive common lymphocyte progenitor
has_exact_synonym: CD10-positive common lymphoid precursor
has_obo_namespace: cell
comment: These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617).

CD34-positive, CD38-negative hematopoietic stem cell
type: Class
equivalent class: Class
  intersection of: hematopoietic stem cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001408
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001483
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001892
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001945
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001003
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001786
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001809
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001843
equivalent class: Class
  intersection of: hematopoietic stem cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001003
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001786
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001809
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001843
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001408
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001483
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001892
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001945
subclass of: hematopoietic stem cell
subclass of: PR_000050567
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001408
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001483
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001892
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001945
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001003
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001786
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001809
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001843
textual definition: CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive.
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: CALOHA:TS-0448
database_cross_reference: FMA:86475
has_exact_synonym: CD133-positive hematopoietic stem cell
has_obo_namespace: cell
in subset: cellxgene subset
comment: Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617).

CD34-positive, CD38-positive common myeloid progenitor
type: Class
equivalent class: Class
  intersection of: common myeloid progenitor, CD34-positive
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001015
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001836
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001867
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001898
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001408
  intersection of: Restriction
    on property: has low plasma membrane amount
    some values from: PR_000001865
equivalent class: Class
  intersection of: common myeloid progenitor, CD34-positive
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001408
  intersection of: Restriction
    on property: has_low_plasma_membrane_amount
    some values from: PR_000001865
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001015
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001836
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001867
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001898
subclass of: CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
subclass of: common myeloid progenitor, CD34-positive
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001015
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001836
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001867
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001898
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001408
subclass of: Restriction
  on property: develops from
  some values from: CD34-positive, CD38-negative multipotent progenitor cell
subclass of: Restriction
  on property: has low plasma membrane amount
  some values from: PR_000001865
textual definition: A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative.
imported from: cl.owl
imported from: mondo.owl
has_narrow_synonym: CD71-positive common myeloid precursor
has_obo_namespace: cell
comment: Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617).

CD7-negative lymphoid progenitor cell
type: Class
equivalent class: Class
  intersection of: common lymphoid progenitor
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001015
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001836
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001003
equivalent class: Class
  intersection of: common lymphoid progenitor
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001003
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001015
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001836
subclass of: common lymphoid progenitor
subclass of: CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
subclass of: PR_000050567
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001015
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001836
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001003
subclass of: Restriction
  on property: develops from
  some values from: CD34-positive, CD38-positive common lymphoid progenitor
textual definition: CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative.
imported from: cl.owl
imported from: mondo.owl
has_exact_synonym: CD7-negative lymphoid precursor
has_obo_namespace: cell
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617).

bone cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001474
subclass of: cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001474
textual definition: A connective tissue cell found in bone.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
contributor: https://orcid.org/0000-0001-9990-8331
creation date: 2011-11-16T04:28:16Z
in subset: general cell types upper slim
in subset: human reference atlas

common myeloid progenitor, CD34-positive
type: Class
equivalent class: Class
  intersection of: common myeloid progenitor
  intersection of: Restriction
    on property: has part
    some values from: PR_000001944
  intersection of: Restriction
    on property: has part
    some values from: PR_000005307
  intersection of: Restriction
    on property: has part
    some values from: PR_000007857
  intersection of: Restriction
    on property: has part
    some values from: PR_000007858
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001003
  intersection of: Restriction
    on property: capable of
    some values from: GO_0002573
  intersection of: Restriction
    on property: capable of
    some values from: GO_0043011
subclass of: common myeloid progenitor
subclass of: progenitor cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: PR_000001944
subclass of: Restriction
  on property: has part
  some values from: PR_000005307
subclass of: Restriction
  on property: has part
  some values from: PR_000007857
subclass of: Restriction
  on property: has part
  some values from: PR_000007858
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001003
subclass of: Restriction
  on property: capable of
  some values from: GO_0043011
textual definition: A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1.
imported from: cl.owl
imported from: mondo.owl
has_broad_synonym: CMP
has_exact_synonym: common myeloid precursor, CD34-positive
has_obo_namespace: cell
has_related_synonym: CFU-GEMM
has_related_synonym: CFU-S
has_related_synonym: CMP
has_related_synonym: colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte
has_related_synonym: multipotential myeloid stem cell
has_related_synonym: myeloid stem cell
has_related_synonym: pluripotent stem cell (bone marrow)
comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.

hematopoietic oligopotent progenitor cell, lineage-negative
type: Class
equivalent class: Class
  intersection of: hematopoietic oligopotent progenitor cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002981
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001401
equivalent class: Class
  intersection of: hematopoietic oligopotent progenitor cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001401
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001012
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001024
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001083
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001084
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001289
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001839
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001889
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002978
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000002981
subclass of: hematopoietic oligopotent progenitor cell
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001004
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001012
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001024
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001083
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001084
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001289
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001839
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001889
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002978
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000002981
subclass of: Restriction
  on property: develops from
  some values from: hematopoietic multipotent progenitor cell
textual definition: A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers.
imported from: cl.owl
imported from: mondo.owl
contributor: https://orcid.org/0000-0003-1980-3228
created by: tmeehan
creation date: 2010-01-06T03:43:27Z
has_obo_namespace: cell

innate lymphoid cell
type: Class
equivalent class: Class
  intersection of: lymphocyte
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001002
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: capable of
    some values from: GO_0001816
  intersection of: Restriction
    on property: capable of
    some values from: GO_0045087
subclass of: lymphocyte
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001002
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: capable of
  some values from: GO_0001816
subclass of: Restriction
  on property: capable of
  some values from: GO_0045087
textual definition: A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
contributor: https://orcid.org/0000-0001-9990-8331
date: 2017-01-30T20:20:48Z
in subset: blood and immune upper slim
in subset: cellxgene subset
in subset: human reference atlas

group 1 innate lymphoid cell
type: Class
equivalent class: Class
  intersection of: innate lymphoid cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0032609
subclass of: innate lymphoid cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0032609
textual definition: An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
contributor: https://orcid.org/0000-0001-9990-8331
date: 2017-01-30T20:42:44Z
in subset: human reference atlas

lymphocyte of B lineage, CD19-positive
type: Class
equivalent class: Class
  intersection of: lymphocyte of B lineage
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001002
  intersection of: Restriction
    on property: in taxon
    some values from: NCBITaxon_40674
equivalent class: Class
  intersection of: lymphocyte of B lineage
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001002
  intersection of: Restriction
    on property: in taxon
    some values from: NCBITaxon_40674
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001020
subclass of: lymphocyte of B lineage
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001020
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001002
subclass of: Restriction
  on property: in taxon
  some values from: NCBITaxon_40674
textual definition: A lymphocyte of B lineage that is CD19-positive.
imported from: cl.owl
imported from: mondo.owl
creator: https://orcid.org/0000-0001-9990-8331
contributor: https://orcid.org/0000-0001-9990-8331
has_obo_namespace: cell
comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).

B cell, CD19-positive
type: Class
equivalent class: Class
  intersection of: lymphocyte of B lineage, CD19-positive
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001002
  intersection of: Restriction
    on property: in taxon
    some values from: NCBITaxon_40674
  intersection of: Restriction
    on property: capable of
    some values from: GO_0019724
subclass of: B cell
subclass of: lymphocyte of B lineage, CD19-positive
textual definition: A B cell that is CD19-positive.
imported from: cl.owl
imported from: mondo.owl
creator: https://orcid.org/0000-0001-9990-8331
contributor: https://orcid.org/0000-0001-9990-8331
has_exact_synonym: B lymphocyte, CD19-positive
has_exact_synonym: B-cell, CD19-positive
has_exact_synonym: B-lymphocyte, CD19-positive
has_exact_synonym: CD19+ B cell
has_exact_synonym: CD19-positive B cell
has_obo_namespace: cell

macrophage dendritic cell progenitor
type: Class
equivalent class: Class
  intersection of: hematopoietic oligopotent progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030224
  intersection of: Restriction
    on property: capable of
    some values from: GO_0043011
subclass of: myeloid cell
subclass of: hematopoietic oligopotent progenitor cell
subclass of: progenitor cell
subclass of: Restriction
  on property: develops from
  some values from: granulocyte monocyte progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030224
subclass of: Restriction
  on property: capable of
  some values from: GO_0043011
textual definition: A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages.
imported from: cl.owl
imported from: mondo.owl
contributor: https://orcid.org/0000-0003-1980-3228
created by: tmeehan
creation date: 2010-01-19T02:51:58Z
has_exact_synonym: MDP
has_obo_namespace: cell
in subset: cellxgene subset

basophil mast progenitor cell
type: Class
equivalent class: Class
  intersection of: myeloid lineage restricted progenitor cell
  intersection of: Restriction
    on property: has part
    some values from: PR_000005307
  intersection of: Restriction
    on property: has part
    some values from: PR_000007857
  intersection of: Restriction
    on property: has part
    some values from: PR_000007858
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000007431
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000016401
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001867
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030221
  intersection of: Restriction
    on property: capable of
    some values from: GO_0060374
subclass of: myeloid cell
subclass of: granulocytopoietic cell
subclass of: PR_000050567
subclass of: Restriction
  on property: has part
  some values from: PR_000005307
subclass of: Restriction
  on property: has part
  some values from: PR_000007857
subclass of: Restriction
  on property: has part
  some values from: PR_000007858
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000007431
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000016401
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001867
subclass of: Restriction
  on property: develops from
  some values from: granulocyte monocyte progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030221
subclass of: Restriction
  on property: capable of
  some values from: GO_0060374
textual definition: A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-04-27T12:46:33Z
has_exact_synonym: BMCP
in subset: cellxgene subset
comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low.

hematopoietic lineage restricted progenitor cell
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001400
subclass of: hematopoietic cell
subclass of: hematopoietic precursor cell
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0001400
subclass of: Restriction
  on property: develops from
  some values from: hematopoietic oligopotent progenitor cell
textual definition: A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
contributor: https://orcid.org/0000-0003-1980-3228
created by: tmeehan
creation date: 2010-01-06T03:43:20Z
has_obo_namespace: cell
in subset: blood and immune upper slim

hematopoietic oligopotent progenitor cell
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0001401
subclass of: hematopoietic cell
subclass of: hematopoietic precursor cell
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0001401
subclass of: Restriction
  on property: develops from
  some values from: hematopoietic multipotent progenitor cell
textual definition: A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
contributor: https://orcid.org/0000-0003-1980-3228
created by: tmeehan
creation date: 2010-01-06T03:43:27Z
has_obo_namespace: cell
in subset: blood and immune upper slim
comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).

immature NK T cell stage I
type: Class
equivalent class: Class
  intersection of: immature NK T cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001307
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001874
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000001932
  intersection of: Restriction
    on property: has low plasma membrane amount
    some values from: PR_000001004
  intersection of: Restriction
    on property: has low plasma membrane amount
    some values from: PR_000025402
subclass of: immature NK T cell
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001307
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001874
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000001932
subclass of: Restriction
  on property: has low plasma membrane amount
  some values from: PR_000001004
subclass of: Restriction
  on property: has low plasma membrane amount
  some values from: PR_000025402
textual definition: A CD24-high, CD4-low, CD8-low, CD44-negative, NK1.1-negative NK T cell.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2009-10-29T04:09:16Z

immature NK T cell stage II
type: Class
equivalent class: Class
  intersection of: immature NK T cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001307
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001874
  intersection of: Restriction
    on property: has low plasma membrane amount
    some values from: PR_000001932
subclass of: immature NK T cell
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001307
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001874
subclass of: Restriction
  on property: develops from
  some values from: immature NK T cell stage I
subclass of: Restriction
  on property: has low plasma membrane amount
  some values from: PR_000001932
textual definition: A CD24-low, CD44-negative, NK1.1-negative NK T cell.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2009-10-29T04:13:43Z
has_exact_synonym: NKT.44-NK1.1-.Th
comment: NKT.44-NK1.1-.Th was assigned as an exact synonym based on sorting strategy displayed at immgene.org.

immature NK T cell stage III
type: Class
equivalent class: Class
  intersection of: immature NK T cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001874
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001307
  intersection of: Restriction
    on property: has low plasma membrane amount
    some values from: PR_000001008
  intersection of: Restriction
    on property: has low plasma membrane amount
    some values from: PR_000001932
subclass of: immature NK T cell
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001874
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001307
subclass of: Restriction
  on property: develops from
  some values from: immature NK T cell stage II
subclass of: Restriction
  on property: has low plasma membrane amount
  some values from: PR_000001008
subclass of: Restriction
  on property: has low plasma membrane amount
  some values from: PR_000001932
textual definition: A CD24-low, CD44-positive, DX5-low, NK1.1-negative NK T cell.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2009-10-29T04:14:48Z
has_broad_synonym: NKT.44+.NK1.1-.Th

immature NK T cell stage IV
type: Class
equivalent class: Class
  intersection of: immature NK T cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001874
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001307
  intersection of: Restriction
    on property: has high plasma membrane amount
    some values from: PR_000001008
  intersection of: Restriction
    on property: has low plasma membrane amount
    some values from: PR_000001932
subclass of: immature NK T cell
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001874
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001307
subclass of: Restriction
  on property: develops from
  some values from: immature NK T cell stage III
subclass of: Restriction
  on property: has high plasma membrane amount
  some values from: PR_000001008
subclass of: Restriction
  on property: has low plasma membrane amount
  some values from: PR_000001932
textual definition: A CD24-low, CD44-positive, DX5-high, NK1.1-negative NK T cell.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2009-10-29T04:17:38Z
has_broad_synonym: NKT.44+.NK1.1-.Th
in subset: human reference atlas

CD34-positive, CD38-negative multipotent progenitor cell
type: Class
equivalent class: Class
  intersection of: hematopoietic multipotent progenitor cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001015
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001408
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001843
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001003
equivalent class: Class
  intersection of: hematopoietic multipotent progenitor cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001003
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001015
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001408
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001843
subclass of: hematopoietic multipotent progenitor cell
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001015
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001408
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001843
subclass of: Restriction
  on property: develops from
  some values from: CD34-positive, CD38-negative hematopoietic stem cell
textual definition: A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative.
imported from: cl.owl
imported from: mondo.owl
contributor: https://orcid.org/0000-0003-1980-3228
created by: tmeehan
creation date: 2010-01-12T11:14:15Z
has_obo_namespace: cell
comment: Cell markers are associated with human hematopoietic multipotent progenitor cells.

endo-epithelial cell
type: Class
subclass of: epithelial cell
subclass of: Restriction
  on property: develops from
  some values from: endodermal cell
textual definition: An epithelial cell derived from endoderm.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-06-29T03:38:14Z
database_cross_reference: FMA:69075

ecto-epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: develops from
    some values from: ectodermal cell
subclass of: epithelial cell
subclass of: Restriction
  on property: develops from
  some values from: ectodermal cell
textual definition: An epithelial cell derived from ectoderm.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-06-29T03:38:22Z
database_cross_reference: FMA:69074

meso-epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: develops from
    some values from: mesodermal cell
subclass of: epithelial cell
subclass of: Restriction
  on property: develops from
  some values from: mesodermal cell
textual definition: Epithelial cell derived from mesoderm or mesenchyme.
imported from: cl.owl
imported from: hp.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-06-29T03:49:14Z
database_cross_reference: FMA:69076
has_exact_synonym: epithelial mesenchymal cell

bone marrow cell
type: Class
equivalent class: Class
  intersection of: bone cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002371
subclass of: bone cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002371
textual definition: A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-07-22T04:48:15Z
database_cross_reference: BTO:0004850
database_cross_reference: FMA:83621
database_cross_reference: MESH:D001854
in subset: cellxgene subset
comment: MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense.

endothelial cell of vascular tree
type: Class
subclass of: endothelial cell
textual definition: An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.
imported from: cl.owl
imported from: hp.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-08-24T02:06:40Z
database_cross_reference: BTO:0001854
database_cross_reference: CALOHA:TS-1106
database_cross_reference: FMA:67755
has_exact_synonym: vascular endothelial cell
has_narrow_synonym: cubodial endothelial cell of vascular tree
in subset: cellxgene subset
comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive.

capillary endothelial cell
type: Class
equivalent class: Class
  intersection of: blood vessel endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001915
subclass of: microvascular endothelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001915
textual definition: An endothelial cell found in capillaries.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-08-24T10:15:00Z
database_cross_reference: BTO:0004956
database_cross_reference: CALOHA:TS-0112
database_cross_reference: FMA:67756
in subset: cellxgene subset
in subset: human reference atlas

extraglomerular mesangial cell
type: Class
equivalent class: Class
  intersection of: connective tissue cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002321
subclass of: mesangial cell
subclass of: juxtaglomerular complex cell
subclass of: renal interstitial pericyte
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002321
textual definition: A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-08-25T02:20:55Z
database_cross_reference: FMA:84143
database_cross_reference: KUPO:0001033
has_exact_synonym: Goormaghtigh cell
has_exact_synonym: polar cushion cells
has_related_synonym: lacis cell

glomerular endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0000074
subclass of: endothelial cell
subclass of: fenestrated cell
subclass of: glomerular cell
textual definition: An endothelial cell found in the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-08-26T10:59:44Z
database_cross_reference: BTO:0004632
database_cross_reference: FMA:70970
in subset: cellxgene subset
in subset: kidney upper slim

granulocytopoietic cell
type: Class
equivalent class: Class
  intersection of: myeloid lineage restricted progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030851
subclass of: myeloid lineage restricted progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030851
textual definition: A cell involved in the formation of a granulocyte.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-08-30T12:54:27Z
database_cross_reference: FMA:83519
in subset: cellxgene subset

monopoietic cell
type: Class
equivalent class: Class
  intersection of: myeloid lineage restricted progenitor cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030224
subclass of: myeloid lineage restricted progenitor cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030224
textual definition: A cell involved in the formation of a monocyte (monopoiesis).
imported from: cl.owl
imported from: mondo.owl
contributor: https://orcid.org/0000-0003-1980-3228
created by: tmeehan
creation date: 2010-08-30T01:27:48Z
database_cross_reference: FMA:83552
has_obo_namespace: cell

renal beta-intercalated cell
type: Class
subclass of: renal intercalated cell
textual definition: A renal intercalated cell that secretes base and reabsorbs acid in the distal segments of the kidney tubule to maintain acid/base balance.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-09-02T01:43:55Z
has_exact_synonym: type B intercalated cell
has_exact_synonym: type B-IC
in subset: cellxgene subset
in subset: human reference atlas

nucleate cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0002505
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0002505
subclass of: cell
subclass of: native cell
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0002505
textual definition: A cell containing at least one nucleus.
imported from: cl.owl
imported from: mondo.owl
contributor: https://orcid.org/0000-0003-1980-3228
created by: tmeehan
creation date: 2010-09-07T03:32:33Z
database_cross_reference: FMA:67513
has_obo_namespace: cell

histamine secreting cell
type: Class
equivalent class: Class
  intersection of: secretory cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0001821
subclass of: biogenic amine secreting cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0001821
textual definition: A cell type that secretes histamine.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-09-10T03:04:42Z

epithelial cell of thymus
type: Class
equivalent class: Class
  intersection of: endo-epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002370
subclass of: endo-epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002370
textual definition: An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-09-13T02:34:22Z
database_cross_reference: CALOHA:TS-1040
database_cross_reference: FMA:72208
has_exact_synonym: epithelial cell of thymus gland
has_exact_synonym: epithelial reticular cell
has_exact_synonym: epithelial reticular cell of thymus
has_exact_synonym: thymic epithelial cell
in subset: cellxgene subset

epithelial cell of distal tubule
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004135
subclass of: meso-epithelial cell
subclass of: nephron tubule epithelial cell
subclass of: kidney cortex tubule cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004135
textual definition: An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH.
imported from: cl.owl
database_cross_reference: FMA:70981
database_cross_reference: KUPO:0001055
has_exact_synonym: kidney distal tubule epithelial cell
in subset: kidney upper slim

epithelial cell of proximal tubule
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004134
subclass of: brush border epithelial cell
subclass of: meso-epithelial cell
subclass of: nephron tubule epithelial cell
subclass of: kidney cortex tubule cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004134
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000229
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000002628
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000004036
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000006561
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000008029
textual definition: An epithelial cell of the proximal tubule of the kidney.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: FMA:70973
database_cross_reference: KUPO:0001044
has_exact_synonym: kidney proximal tubule epithelial cell
in subset: cellxgene subset
in subset: kidney upper slim
in subset: human reference atlas

brush border cell of the proximal tubule
type: Class
subclass of: epithelial cell of proximal tubule
textual definition: A brush border epithelial cell located in the proximal tubule of the kidney that detects fluid flow.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-09-14T11:29:20Z

neural cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001016
subclass of: cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001016
textual definition: A cell that is part of the nervous system.
imported from: cl.owl
imported from: hp.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-09-15T01:34:57Z
database_cross_reference: CALOHA:TS-2040
database_cross_reference: FMA:70333
in subset: cellxgene subset

connective tissue cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002384
equivalent class: Class
  intersection of: somatic cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002384
subclass of: cell
subclass of: animal cell
subclass of: somatic cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002384
textual definition: A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
contributor: https://orcid.org/0000-0003-1980-3228
created by: tmeehan
creation date: 2010-09-15T03:01:54Z
has_alternative_id: CL:1000406
database_cross_reference: CALOHA:TS-2096
database_cross_reference: FMA:63875
database_cross_reference: MESH:D003239
has_obo_namespace: cell
in subset: cellxgene subset

embryonic cell (metazoa)
type: Class
subclass of: cell
subclass of: animal cell
textual definition: A cell of the embryo.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
contributor: https://orcid.org/0000-0003-1980-3228
created by: tmeehan
creation date: 2010-09-15T03:39:21Z
database_cross_reference: CALOHA:TS-0263
database_cross_reference: FMA:82840
database_cross_reference: FMA:82841
database_cross_reference: WBbt:0007028
has_obo_namespace: cell

progenitor cell of endocrine pancreas
type: Class
subclass of: multi fate stem cell
textual definition: A multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1.
imported from: mondo.owl
created by: tmeehan
creation date: 2010-09-21T04:41:06Z
has_exact_synonym: pancreatic endocrine progenitor
has_exact_synonym: pancreatic islet progenitor cell
has_obo_namespace: cell

somatic cell
type: Class
subclass of: native cell
textual definition: A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell).
imported from: mondo.owl
created by: tmeehan
creation date: 2010-09-24T09:44:42Z
database_cross_reference: BTO:0001268
database_cross_reference: FMA:72300
database_cross_reference: WBbt:0008378
has_obo_namespace: cell
in subset: upper level

mature T cell
type: Class
equivalent class: Class
  intersection of: T cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: GO_0042101
  intersection of: Restriction
    on property: output of
    some values from: GO_0045058
subclass of: T cell
subclass of: Restriction
  on property: has plasma membrane part
  some values from: GO_0042101
subclass of: Restriction
  on property: output of
  some values from: GO_0045058
textual definition: A T cell that expresses a T cell receptor complex and has completed T cell selection.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-10-12T01:56:15Z
has_exact_synonym: CD3e-positive T cell
has_exact_synonym: mature T-cell
has_related_synonym: CD3epsilon T cell
in subset: cellxgene subset

immature T cell
type: Class
equivalent class: Class
  intersection of: T cell
  intersection of: Restriction
    on property: has_not_completed
    some values from: GO_0045058
subclass of: T cell
subclass of: Restriction
  on property: has_not_completed
  some values from: GO_0045058
textual definition: A T cell that has not completed T cell selection.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-10-12T01:56:17Z
database_cross_reference: BTO:0001372
database_cross_reference: CALOHA:TS-1042
has_exact_synonym: immature T-cell
in subset: blood and immune upper slim
in subset: cellxgene subset

early T lineage precursor
type: Class
equivalent class: Class
  intersection of: pro-T cell
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001380
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001307
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001869
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000002065
subclass of: pro-T cell
subclass of: PR_000050567
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001380
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001307
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001869
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000002065
textual definition: A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-10-21T01:16:24Z
has_exact_synonym: ETP
has_exact_synonym: preT.ETP.Th
in subset: cellxgene subset
in subset: human reference atlas
comment: ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative.

CD11b-positive dendritic cell
type: Class
equivalent class: Class
  intersection of: conventional dendritic cell
  intersection of: Restriction
    on property: has plasma membrane part
    some values from: PR_000001012
subclass of: conventional dendritic cell
subclass of: Restriction
  on property: has plasma membrane part
  some values from: PR_000001012
textual definition: A conventional dendritic cell that expresses CD11b (ITGAM).
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-11-23T01:50:05Z

double negative thymocyte
type: Class
equivalent class: Class
  intersection of: thymocyte
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000001004
  intersection of: Restriction
    on property: lacks_plasma_membrane_part
    some values from: PR_000025402
subclass of: thymocyte
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000001004
subclass of: Restriction
  on property: lacks_plasma_membrane_part
  some values from: PR_000025402
textual definition: A thymocyte that lacks expression of CD4 and CD8.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-12-06T03:03:38Z
has_exact_synonym: CD4-CD8- T cell
has_exact_synonym: double negative T cell
in subset: cellxgene subset
comment: These are precursors to mature T cells; normally, they do not circulate, but are found in the thymus and they have not undergone rearrangement of the alpha and beta T cell receptor genes.

cardiocyte
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0007100
equivalent class: Class
  intersection of: somatic cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0007100
subclass of: cell
subclass of: animal cell
subclass of: somatic cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0007100
textual definition: A cell located in the heart, including both muscle and non muscle cells.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
contributor: https://orcid.org/0000-0003-1980-3228
created by: tmeehan
creation date: 2010-12-07T09:37:22Z
database_cross_reference: BTO:0001539
database_cross_reference: CALOHA:TS-0115
database_cross_reference: FMA:83808
database_cross_reference: FMA:84791
has_exact_synonym: heart cell
has_obo_namespace: cell
comment: From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart.

kidney epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002113
subclass of: epithelial cell
subclass of: kidney cell
textual definition: An epithelial cell of the kidney.
imported from: cl.owl
imported from: hp.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2011-02-08T10:46:34Z
database_cross_reference: KUPO:0001019
in subset: cellxgene subset

interrenal epithelial cell
type: Class
subclass of: kidney epithelial cell
textual definition: An interrenal epithelial kidney cell is an epithelial cell found in the anterior kidney of teleosts fish. This cell type is arranged in layers around the posterior cardinal vein and contains many mitochondria with tubulovesicular cristae. Interrenal chromaffin cells are interspersed among the tissue layer created by this cell type.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2011-02-08T11:03:32Z

renal filtration cell
type: Class
subclass of: excretory cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001008
textual definition: A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2011-02-08T01:37:59Z

mesonephric podocyte
type: Class
equivalent class: Class
  intersection of: podocyte
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0000080
subclass of: podocyte
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000080
textual definition: A specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the mesonephros.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2011-02-08T01:58:30Z
has_exact_synonym: mesonephric glomerular visceral epithelial cell

metanephric podocyte
type: Class
equivalent class: Class
  intersection of: podocyte
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0000081
subclass of: podocyte
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000081
textual definition: A specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the metanephros.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2011-02-08T02:02:13Z
has_exact_synonym: metanephric glomerular visceral epithelial cell

vein endothelial cell
type: Class
equivalent class: Class
  intersection of: blood vessel endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001638
subclass of: blood vessel endothelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001638
textual definition: An endothelial cell that is part of the vein.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2011-02-28T03:48:11Z
database_cross_reference: FMA:62104
database_cross_reference: KUPO:0001099
has_exact_synonym: endothelial cell of vein
has_exact_synonym: venous endothelial cell
in subset: cellxgene subset
in subset: human reference atlas

embryonic blood vessel endothelial progenitor cell
type: Class
subclass of: mesodermal cell
textual definition: An endothelial progenitor cell that participates in angiogenesis during development.
imported from: cl.owl
imported from: hp.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2011-02-28T04:20:39Z
comment: See CL:0002619.

Schwann cell
type: Class
subclass of: glial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000010
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000004684
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000005803
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000006332
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000009378
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000028513
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000064785
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000253559
textual definition: A glial cell that myelinates or ensheathes axons in the peripheral nervous system.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2011-03-02T01:19:27Z
database_cross_reference: BTO:0001220
database_cross_reference: CALOHA:TS-0898
database_cross_reference: MESH:D012583
in subset: cellxgene subset
in subset: human reference atlas
comment: A myelinating Schwann cell wraps around a single axon. Myelination occurs in larger diameter axons, while a process called ensheathment occurs on smaller diameter axons in which a single cell wraps around multiple small, unmyelinated axons separating them with a thin layer of cytoplasm. The structure formed is called a Remak bundle.

renal cortical epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001225
subclass of: kidney epithelial cell
subclass of: kidney cortical cell
textual definition: An epithelial cell of the kidney cortex.
imported from: cl.owl
database_cross_reference: KUPO:0001016

kidney cortical cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001225
subclass of: kidney cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001225
textual definition: A cell that is part of a cortex of kidney.
imported from: cl.owl
contributor: https://orcid.org/0000-0002-0956-8634
creation date: 2011-10-25T03:49:41Z

renal principal cell
type: Class
subclass of: columnar/cuboidal epithelial cell
subclass of: kidney epithelial cell
textual definition: A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system.
imported from: cl.owl
imported from: hp.owl
in subset: cellxgene subset

renal intercalated cell
type: Class
subclass of: columnar/cuboidal epithelial cell
subclass of: meso-epithelial cell
subclass of: epithelial cell of nephron
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000004914
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000005172
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000083697
textual definition: A cuboidal epithelial cell of the kidney that regulates acid/base balance.
imported from: cl.owl
database_cross_reference: FMA:86560
has_exact_synonym: intercalated cell
in subset: cellxgene subset
comment: Intercalated cells are also called “mitochondria-rich cells”, reflecting the high levels of round mitochondria at their apical pole, or in their cytoplasm, a distribution that is quite different from that of other kidney tubule cells, which accumulated mitochondria around the basolateral membrane. These cells also have numerous irregular apical microvilli compared with the surrounding segment-specific cells. Intercalated cells lack a central cilium, at least in the cortex, which also differentiates them from the adjacent principal cells.

renal alpha-intercalated cell
type: Class
subclass of: renal intercalated cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0046717
textual definition: A cuboidal epithelial cell of the kidney which secretes acid and reabsorbs base to regulate acid/base balance.
imported from: cl.owl
has_exact_synonym: type A intercalated cell
has_exact_synonym: type A-IC
in subset: cellxgene subset
comment: Type A intercalated cells are the more abundant type of intercalated cell in the outer stripe of the outer medulla in most mammalian species.

skeletogenic cell
type: Class
subclass of: cell
textual definition: Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized).
imported from: cl.owl
contributor: https://orcid.org/0000-0001-9114-8737
creation date: 2012-06-15T02:51:27Z
has_exact_synonym: scleroblast
comment: Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)

premigratory neural crest cell
type: Class
subclass of: neural crest cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002342
subclass of: Restriction
  on property: develops from
  some values from: neurectodermal cell
textual definition: Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells.
imported from: cl.owl
imported from: hp.owl
contributor: https://orcid.org/0000-0001-9114-8737
creation date: 2012-06-27T08:27:35Z

non-striated muscle cell
type: Class
subclass of: muscle cell
textual definition: Any muscle cell in which the fibers are not organised into sarcomeres.
imported from: cl.owl
imported from: mondo.owl

hematopoietic precursor cell
type: Class
subclass of: hematopoietic cell
textual definition: Any hematopoietic cell that is a precursor of some other hematopoietic cell type.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
in subset: cellxgene subset

visceral muscle cell
type: Class
equivalent class: Class
  intersection of: muscle cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_8600004
subclass of: muscle cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_8600004
textual definition: A muscle cell that is part of some visceral muscle
textual definition: A muscle cell that is part of some visceral muscle.
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: FBbt:00005070

mesenchymal cell
type: Class
subclass of: cell
subclass of: motile cell
subclass of: somatic cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0003104
subclass of: Restriction
  on property: capable of
  some values from: GO_0016477
textual definition: A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
has_exact_synonym: mesenchyme cell
in subset: cellxgene subset
in subset: human reference atlas

pancreatic endocrine cell
type: Class
equivalent class: Class
  intersection of: endocrine cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001264
subclass of: endocrine cell
textual definition: An endocrine cell that is part of the pancreas.
imported from: mondo.owl
has_obo_namespace: cell

mural cell
type: Class
subclass of: somatic cell
subclass of: perivascular cell
textual definition: Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
present_in_taxon: NCBITaxon 9606
contributor: https://orcid.org/0000-0002-7073-9172
created by: dos
creation date: 2020-02-29T17:33:55Z
in subset: added for HCA
in subset: cellxgene subset
in subset: human reference atlas

microcirculation associated smooth muscle cell
type: Class
equivalent class: Class
  intersection of: vascular associated smooth muscle cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0010523
subclass of: vascular associated smooth muscle cell
subclass of: mural cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0010523
imported from: cl.owl
contributor: https://orcid.org/0000-0002-7073-9172
creation date: 2020-02-29T17:37:00Z

nephrogenic zone cell
type: Class
equivalent class: Class
  intersection of: kidney cortical cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0009871
subclass of: kidney cortical cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0009871
textual definition: A kidney cortical cell that is part of the nephrogenic zone.
imported from: cl.owl
contributor: https://orcid.org/0000-0002-2825-0621
has_exact_synonym: cortical nephrogenic niche cell
has_exact_synonym: cortical nephrogenic zone cell
in subset: added for HCA

zygote
type: Class
subclass of: cell
textual definition: A zygote in a plant or an animal.
imported from: cl.owl
imported from: hp.owl
database_cross_reference: MESH:D015053

neural crest cell
type: Class
subclass of: multi fate stem cell
subclass of: embryonic cell (metazoa)
textual definition: A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.
imported from: cl.owl
imported from: hp.owl
in subset: cellxgene subset

progenitor cell
type: Class
equivalent class: Class
  intersection of: precursor cell
  intersection of: Restriction
    on property: develops from
    some values from: stem cell
subclass of: precursor cell
subclass of: Restriction
  on property: develops from
  some values from: stem cell
textual definition: A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses.
imported from: cl.owl
imported from: mondo.owl
contributor: https://orcid.org/0000-0001-5208-3432
created by: http://orcid.org/0000-0001-5208-3432
in subset: cellxgene subset

precursor cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030154
equivalent class: Class
  intersection of: native cell
  intersection of: Restriction
    on property: capable of
    some values from: GO_0030154
subclass of: cell
subclass of: native cell
subclass of: Restriction
  on property: capable of
  some values from: GO_0030154
textual definition: A cell that, by division or terminal differentiation, can give rise to other cell types.
imported from: cl.owl
imported from: hp.owl
imported from: mondo.owl
in subset: cellxgene subset
comment: Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell.

neutrophillic cytoplasm
type: Class
equivalent class: Class
  intersection of: GO_0005737
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0070046
subclass of: GO_0005737
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0070046
textual definition: Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2010-05-25T01:36:34Z

acidophilic cytoplasm
type: Class
equivalent class: Class
  intersection of: GO_0005737
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0002418
subclass of: GO_0005737
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0002418
textual definition: Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain.
imported from: cl.owl
imported from: hp.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2009-12-22T04:23:25Z
has_narrow_synonym: eosinophilic

basophilic cytoplasm
type: Class
equivalent class: Class
  intersection of: GO_0005737
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0002094
subclass of: GO_0005737
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0002094
textual definition: Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions.
imported from: cl.owl
imported from: hp.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2009-12-22T04:24:54Z

polychromatophilic cytoplasm
type: Class
equivalent class: Class
  intersection of: GO_0005737
  intersection of: Restriction
    on property: bearer of
    some values from: PATO_0070047
subclass of: GO_0005737
subclass of: Restriction
  on property: bearer of
  some values from: PATO_0070047
textual definition: Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions.
imported from: cl.owl
imported from: hp.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2009-12-28T04:25:23Z

cartwheel heterochromatin
type: Class
subclass of: GO_0000792
textual definition: Heterochromatin that is arranged in a carthwheel pattern.
imported from: cl.owl
contributor: https://orcid.org/0000-0003-1980-3228
creation date: 2009-12-28T04:28:35Z

blood vessel smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001981
subclass of: vascular associated smooth muscle cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001981
textual definition: A smooth muscle cell that is part of any blood vessel.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
contributor: 0000-0003-2034-601X
date: 2020-07-21T12:42:48Z
has_exact_synonym: smooth muscle cell of blood vessel
in subset: human reference atlas

mesonephric nephron tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005329
subclass of: epithelial cell of nephron
subclass of: kidney tubule cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005329
imported from: cl.owl

pronephric nephron tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005310
subclass of: epithelial cell of nephron
subclass of: kidney tubule cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005310
imported from: cl.owl

metanephric nephron tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005146
subclass of: epithelial cell of nephron
subclass of: kidney tubule cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005146
imported from: cl.owl

endothelial cell of arteriole
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001980
subclass of: blood vessel endothelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001980
textual definition: An endothelial cell that is part of the arteriole.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: FMA:67760
database_cross_reference: KUPO:0001097
in subset: human reference atlas

endothelial cell of artery
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001637
subclass of: blood vessel endothelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001917
textual definition: A blood vessel endothelial cell that is part of an arterial endothelium.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: BTO:0004758
database_cross_reference: FMA:67761
database_cross_reference: KUPO:0001095
has_exact_synonym: arterial endothelial cell
in subset: cellxgene subset
in subset: human reference atlas

epithelial cell of nephron
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001285
subclass of: kidney epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001285
textual definition: An epithelial cell that is part of the nephron.
imported from: cl.owl
database_cross_reference: FMA:70965
in subset: cellxgene subset

epithelial cell of glomerular capsule
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001230
subclass of: kidney glomerular epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001230
textual definition: An epithelial cell that is part of the glomerular capsule.
imported from: cl.owl
database_cross_reference: FMA:70966
database_cross_reference: KUPO:0001034
has_exact_synonym: Bowmans capsule epithelial cell
has_exact_synonym: epithelial cell of Bowman's capsule
in subset: cellxgene subset
in subset: kidney upper slim

parietal epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005750
subclass of: epithelial cell of glomerular capsule
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005750
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000003075
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000007412
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000007490
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000009076
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000286204
textual definition: An epithelial cell that is part of the glomerular parietal epithelium.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: FMA:70968
database_cross_reference: KUPO:0001035
has_exact_synonym: epithelial cell of parietal layer of glomerular capsule
in subset: cellxgene subset
in subset: human reference atlas

epithelial cell of intermediate tubule
type: Class
equivalent class: Class
  intersection of: nephron tubule epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004136
subclass of: kidney loop of Henle epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004136
textual definition: An epithelial cell that is part of the intermediate tubule.
imported from: cl.owl
database_cross_reference: FMA:70980

kidney collecting duct epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001232
subclass of: non-branched duct epithelial cell
subclass of: epithelial cell of nephron
subclass of: kidney collecting duct cell
textual definition: An epithelial cell that is part of the collecting duct of renal tubule.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: FMA:70982
database_cross_reference: KUPO:0001059
has_exact_synonym: epithelial cell of renal collecting tubule
in subset: cellxgene subset
in subset: kidney upper slim
in subset: human reference atlas

nephron tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004810
subclass of: epithelial cell of nephron
subclass of: kidney tubule cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004810
textual definition: An epithelial cell that is part of a nephron tubule.
imported from: cl.owl
database_cross_reference: FMA:86785
database_cross_reference: KUPO:0001022
has_exact_synonym: kidney tubule epithelial cell
in subset: cellxgene subset
comment: This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON.

kidney cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002113
subclass of: cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002113
textual definition: A cell that is part of a kidney.
imported from: cl.owl
imported from: hp.owl
database_cross_reference: KUPO:0001010
in subset: cellxgene subset

kidney interstitial cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005215
subclass of: kidney cell
subclass of: interstitial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005215
textual definition: A cell that is part of kidney interstitium.
imported from: cl.owl
database_cross_reference: KUPO:0001013
in subset: cellxgene subset
in subset: kidney upper slim

kidney medulla cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0000362
subclass of: kidney cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000362
textual definition: A cell that is part of a renal medulla.
imported from: cl.owl
database_cross_reference: KUPO:0001017

kidney pelvis cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001224
subclass of: kidney cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001224
textual definition: A cell that is part of a renal pelvis.
imported from: cl.owl
database_cross_reference: KUPO:0001018
in subset: kidney upper slim

kidney tubule cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001231
subclass of: kidney cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001231
textual definition: A cell that is part of a nephron tubule.
imported from: cl.owl
database_cross_reference: KUPO:0001020
in subset: kidney upper slim

kidney glomerular epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004188
subclass of: glomerular cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004188
imported from: cl.owl
database_cross_reference: KUPO:0001023
in subset: cellxgene subset

kidney medulla collecting duct epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005185
subclass of: kidney collecting duct epithelial cell
subclass of: kidney medulla cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005185
textual definition: An epithelial cell that is part of a renal medulla collecting duct.
imported from: cl.owl
database_cross_reference: KUPO:0001060
in subset: kidney upper slim

kidney inner medulla collecting duct epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004205
subclass of: kidney medulla collecting duct epithelial cell
subclass of: kidney inner medulla cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004205
textual definition: An epithelial cell that is part of some inner medullary collecting duct.
imported from: cl.owl
database_cross_reference: KUPO:0001061

kidney outer medulla collecting duct epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004204
subclass of: kidney medulla collecting duct epithelial cell
subclass of: kidney outer medulla cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004204
textual definition: An epithelial cell that is part of an outer medullary collecting duct.
imported from: cl.owl
database_cross_reference: KUPO:0001062

kidney cortex collecting duct epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004203
subclass of: renal cortical epithelial cell
subclass of: kidney collecting duct epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004203
textual definition: An epithelial cell that is part of a cortical collecting duct.
imported from: cl.owl
database_cross_reference: KUPO:0001063

kidney papillary duct principal epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005167
subclass of: kidney collecting duct cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005167
imported from: cl.owl
database_cross_reference: KUPO:0001064
in subset: kidney upper slim

inner renal cortex cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005271
subclass of: kidney cortical cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005271
imported from: cl.owl
database_cross_reference: KUPO:0001111

papillary tips cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0009095
subclass of: kidney pelvis cell
subclass of: kidney inner medulla cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0009095
textual definition: A cell that is part of a tip of a renal papilla.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001112
in subset: cellxgene subset
in subset: human reference atlas

kidney nerve cell
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: has soma location
    some values from: UBERON_0002113
subclass of: kidney interstitial cell
subclass of: peripheral nervous system neuron
subclass of: Restriction
  on property: has soma location
  some values from: UBERON_0002113
imported from: cl.owl
database_cross_reference: KUPO:0001015

kidney corpuscule cell
type: Class
equivalent class: Class
  intersection of: renal cortical epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001229
subclass of: renal cortical epithelial cell
subclass of: epithelial cell of nephron
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001229
imported from: cl.owl
database_cross_reference: KUPO:0001021
in subset: kidney upper slim

kidney cortex tubule cell
type: Class
equivalent class: Class
  intersection of: kidney tubule cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0006853
subclass of: renal cortical epithelial cell
subclass of: epithelial cell of nephron
subclass of: kidney tubule cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0006853
imported from: cl.owl
database_cross_reference: KUPO:0001024
in subset: cellxgene subset

kidney outer medulla cell
type: Class
equivalent class: Class
  intersection of: kidney medulla cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001293
subclass of: kidney medulla cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001293
imported from: cl.owl
database_cross_reference: KUPO:0001025

kidney inner medulla cell
type: Class
equivalent class: Class
  intersection of: kidney medulla cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001294
subclass of: kidney medulla cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001294
imported from: cl.owl
database_cross_reference: KUPO:0001026

juxtaglomerular complex cell
type: Class
equivalent class: Class
  intersection of: kidney cortical cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002303
subclass of: kidney cortical cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002303
imported from: cl.owl
database_cross_reference: KUPO:0001028
has_exact_synonym: juxtaglomerulus cell
in subset: kidney upper slim

kidney cortex interstitial cell
type: Class
equivalent class: Class
  intersection of: kidney interstitial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005270
subclass of: renal cortical epithelial cell
subclass of: kidney interstitial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005270
imported from: cl.owl
database_cross_reference: KUPO:0001091

kidney medulla interstitial cell
type: Class
equivalent class: Class
  intersection of: kidney interstitial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005211
subclass of: kidney interstitial cell
subclass of: kidney medulla cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005211
imported from: cl.owl
database_cross_reference: KUPO:0001092

kidney interstitial myofibroblast
type: Class
subclass of: myofibroblast cell
subclass of: kidney interstitial cell
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001101
in subset: human reference atlas

kidney interstitial fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005215
subclass of: fibroblast
subclass of: kidney interstitial cell
imported from: cl.owl
imported from: hp.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001102
in subset: cellxgene subset
in subset: human reference atlas

kidney interstitial fibrocyte
type: Class
subclass of: fibrocyte
subclass of: kidney interstitial cell
imported from: cl.owl
database_cross_reference: KUPO:0001103

kidney interstitial alternatively activated macrophage
type: Class
subclass of: alternatively activated macrophage
subclass of: kidney interstitial cell
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001106
in subset: human reference atlas

kidney interstitial inflammatory macrophage
type: Class
subclass of: inflammatory macrophage
subclass of: kidney interstitial cell
imported from: cl.owl
database_cross_reference: KUPO:0001107

kidney interstitial suppressor macrophage
type: Class
subclass of: suppressor macrophage
subclass of: kidney interstitial cell
imported from: cl.owl
database_cross_reference: KUPO:0001108

kidney resident macrophage
type: Class
subclass of: tissue-resident macrophage
subclass of: kidney interstitial cell
textual definition: A tissue-resident macrophage that is part of some kidney.
imported from: cl.owl
database_cross_reference: KUPO:0001109
in subset: cellxgene subset

kidney resident dendritic cell
type: Class
subclass of: interstitial dendritic cell
subclass of: kidney interstitial cell
imported from: cl.owl
database_cross_reference: KUPO:0001110

kidney pelvis smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004227
subclass of: smooth muscle cell
subclass of: kidney pelvis cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004227
imported from: cl.owl
database_cross_reference: KUPO:0001113

kidney pelvis urothelial cell
type: Class
equivalent class: Class
  intersection of: kidney epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004788
subclass of: urothelial cell
subclass of: kidney epithelial cell
subclass of: kidney pelvis cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004788
imported from: cl.owl
database_cross_reference: KUPO:0001114
in subset: cellxgene subset

kidney cortex collecting duct principal cell
type: Class
equivalent class: Class
  intersection of: renal principal cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004203
subclass of: kidney cortex collecting duct epithelial cell
subclass of: kidney collecting duct principal cell
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001130
in subset: human reference atlas

kidney cortex collecting duct intercalated cell
type: Class
equivalent class: Class
  intersection of: renal intercalated cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004203
subclass of: kidney cortex collecting duct epithelial cell
subclass of: kidney collecting duct intercalated cell
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001131
in subset: human reference atlas

kidney outer medulla collecting duct principal cell
type: Class
equivalent class: Class
  intersection of: renal principal cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004204
subclass of: kidney outer medulla collecting duct epithelial cell
subclass of: kidney collecting duct principal cell
textual definition: Principal cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may express the epithelial sodium channel (ENaC).
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001132
in subset: human reference atlas

kidney outer medulla collecting duct intercalated cell
type: Class
equivalent class: Class
  intersection of: renal intercalated cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004204
subclass of: kidney outer medulla collecting duct epithelial cell
subclass of: kidney collecting duct intercalated cell
textual definition: Intercalated cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may contribute in the maintenance of acid/base homeostasis.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001133
in subset: human reference atlas

kidney inner medulla collecting duct principal cell
type: Class
equivalent class: Class
  intersection of: renal principal cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004205
subclass of: kidney inner medulla collecting duct epithelial cell
subclass of: kidney collecting duct principal cell
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001134
in subset: human reference atlas

kidney inner medulla collecting duct intercalated cell
type: Class
equivalent class: Class
  intersection of: renal intercalated cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004205
subclass of: kidney inner medulla collecting duct epithelial cell
subclass of: kidney collecting duct intercalated cell
imported from: cl.owl
database_cross_reference: KUPO:0001135

kidney papillary duct intercalated cell
type: Class
equivalent class: Class
  intersection of: renal intercalated cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005167
subclass of: kidney papillary duct principal epithelial cell
subclass of: kidney collecting duct intercalated cell
imported from: cl.owl
database_cross_reference: KUPO:0001136

kidney papillary duct principal cell
type: Class
equivalent class: Class
  intersection of: renal principal cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005167
subclass of: kidney papillary duct principal epithelial cell
subclass of: kidney collecting duct principal cell
imported from: cl.owl
database_cross_reference: KUPO:0001137

glomerular mesangial cell
type: Class
subclass of: phagocyte
subclass of: mesangial cell
subclass of: glomerular cell
subclass of: renal interstitial pericyte
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002320
subclass of: Restriction
  on property: capable of
  some values from: GO_0070252
textual definition: A mesangial cell located among the glomerular capillaries in a renal corpuscle.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001032
has_exact_synonym: intraglomerular mesangial cell
in subset: human reference atlas
comment: Like smooth muscle, a glomerular mesangial cell is contractile and possesses the filaments actin and myosin. The contractile mechanism is also similar to that of smooth muscle, with Ca2+/calmodulin-activated myosin light-chain kinase instigating myosin-actin cross-bridge cycling. Mesangial cell phagocytosis of apoptotic neutrophils involves a novel CD36-independent, alpha(v)beta3/TSP-mediated mechanism that is uncoupled from chemokine secretion, emphasizing the injury-limiting potential of mesangial cell phagocytosis of apoptotic cells.

glomerular cell
type: Class
equivalent class: Class
  intersection of: kidney corpuscule cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0000074
subclass of: kidney corpuscule cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000074
imported from: cl.owl
database_cross_reference: KUPO:0001036

kidney connecting tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: nephron tubule epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005097
subclass of: nephron tubule epithelial cell
subclass of: kidney cortex tubule cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005097
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001058
in subset: cellxgene subset
in subset: kidney upper slim
in subset: human reference atlas

kidney inner medulla interstitial cell
type: Class
equivalent class: Class
  intersection of: kidney medulla interstitial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005214
subclass of: kidney inner medulla cell
subclass of: kidney medulla interstitial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005214
imported from: cl.owl
database_cross_reference: KUPO:0001093

kidney outer medulla interstitial cell
type: Class
equivalent class: Class
  intersection of: kidney medulla interstitial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005213
subclass of: kidney outer medulla cell
subclass of: kidney medulla interstitial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005213
imported from: cl.owl
database_cross_reference: KUPO:0001094

kidney proximal convoluted tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell of proximal tubule
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001287
subclass of: epithelial cell of proximal tubule
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001287
imported from: cl.owl
database_cross_reference: KUPO:0001045
in subset: cellxgene subset

kidney proximal straight tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell of proximal tubule
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001290
subclass of: epithelial cell of proximal tubule
subclass of: kidney outer medulla cell
subclass of: kidney loop of Henle descending limb epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001290
imported from: cl.owl
database_cross_reference: KUPO:0001046
in subset: cellxgene subset

kidney distal convoluted tubule epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell of distal tubule
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001292
subclass of: epithelial cell of distal tubule
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001292
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001056
in subset: cellxgene subset
in subset: kidney upper slim
in subset: human reference atlas

macula densa epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell of distal tubule
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002335
subclass of: epithelial cell of distal tubule
subclass of: juxtaglomerular complex cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002335
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001057
in subset: cellxgene subset
in subset: human reference atlas

kidney blood vessel cell
type: Class
equivalent class: Class
  intersection of: kidney medulla cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0003517
subclass of: renal cortical epithelial cell
subclass of: kidney medulla cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0003517
subclass of: Restriction
  on property: participates in
  some values from: GO_0008015
imported from: cl.owl
database_cross_reference: KUPO:0001014

kidney arterial blood vessel cell
type: Class
equivalent class: Class
  intersection of: kidney blood vessel cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0003644
subclass of: kidney blood vessel cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0003644
imported from: cl.owl
database_cross_reference: KUPO:0001029
in subset: kidney upper slim

kidney capillary endothelial cell
type: Class
equivalent class: Class
  intersection of: kidney blood vessel cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0003527
subclass of: blood vessel endothelial cell
subclass of: kidney blood vessel cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0003527
imported from: cl.owl
database_cross_reference: KUPO:0001030
in subset: cellxgene subset
in subset: kidney upper slim

kidney venous blood vessel cell
type: Class
equivalent class: Class
  intersection of: kidney blood vessel cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001140
subclass of: kidney blood vessel cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001140
imported from: cl.owl
database_cross_reference: KUPO:0001031
in subset: kidney upper slim

kidney loop of Henle epithelial cell
type: Class
equivalent class: Class
  intersection of: nephron tubule epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001288
subclass of: nephron tubule epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001288
imported from: cl.owl
database_cross_reference: KUPO:0001047
in subset: cellxgene subset

glomerular capillary endothelial cell
type: Class
equivalent class: Class
  intersection of: kidney capillary endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004294
subclass of: capillary endothelial cell
subclass of: glomerular endothelial cell
subclass of: kidney glomerular epithelial cell
subclass of: kidney capillary endothelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004294
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000358
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000002321
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000002702
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000005327
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000030845
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000050964
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000051705
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000057520
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001037
in subset: cellxgene subset
in subset: human reference atlas

kidney afferent arteriole cell
type: Class
equivalent class: Class
  intersection of: kidney arterial blood vessel cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004639
subclass of: kidney corpuscule cell
subclass of: kidney arterial blood vessel cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004639
imported from: cl.owl
database_cross_reference: KUPO:0001038

kidney efferent arteriole cell
type: Class
equivalent class: Class
  intersection of: kidney arterial blood vessel cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004640
subclass of: kidney corpuscule cell
subclass of: kidney arterial blood vessel cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004640
imported from: cl.owl
database_cross_reference: KUPO:0001041

kidney loop of Henle ascending limb epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney loop of Henle epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005164
subclass of: epithelial cell of distal tubule
subclass of: kidney loop of Henle epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005164
imported from: cl.owl
database_cross_reference: KUPO:0001048
in subset: cellxgene subset
in subset: kidney upper slim

kidney loop of Henle descending limb epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney loop of Henle epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001289
subclass of: kidney loop of Henle epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001289
imported from: cl.owl
database_cross_reference: KUPO:0001053
in subset: kidney upper slim

peritubular capillary endothelial cell
type: Class
equivalent class: Class
  intersection of: kidney capillary endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005272
subclass of: capillary endothelial cell
subclass of: kidney capillary endothelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0012441
textual definition: An endothelial cell that is part of some peritubular capillary.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001065
in subset: cellxgene subset
in subset: human reference atlas

vasa recta cell
type: Class
equivalent class: Class
  intersection of: kidney capillary endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004726
subclass of: vein endothelial cell
subclass of: kidney capillary endothelial cell
subclass of: kidney venous blood vessel cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004726
imported from: cl.owl
database_cross_reference: KUPO:0001068

kidney cortex artery cell
type: Class
equivalent class: Class
  intersection of: kidney arterial blood vessel cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005268
subclass of: kidney arterial blood vessel cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005268
imported from: cl.owl
database_cross_reference: KUPO:0001077
in subset: cellxgene subset

kidney cortex vein cell
type: Class
equivalent class: Class
  intersection of: kidney venous blood vessel cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005269
subclass of: kidney venous blood vessel cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005269
imported from: cl.owl
database_cross_reference: KUPO:0001084

kidney artery smooth muscle cell
type: Class
subclass of: meso-epithelial cell
subclass of: blood vessel smooth muscle cell
subclass of: kidney arterial blood vessel cell
imported from: cl.owl
database_cross_reference: KUPO:0001096
comment: Note that the source of this term is KUPO:0001096 (artery smooth muscle cell), which we believe actually denotes the kidney specific structure.

kidney arteriole smooth muscle cell
type: Class
subclass of: meso-epithelial cell
subclass of: blood vessel smooth muscle cell
subclass of: kidney arterial blood vessel cell
imported from: cl.owl
database_cross_reference: KUPO:0001098
comment: Note that the source of this term is KUPO:0001098 (arteriole smooth muscle cell), which we believe actually denotes the kidney specific structure.

kidney venous system smooth muscle cell
type: Class
subclass of: meso-epithelial cell
subclass of: blood vessel smooth muscle cell
subclass of: kidney venous blood vessel cell
imported from: cl.owl
database_cross_reference: KUPO:0001100
comment: Note that the source of this term is KUPO:0001068 (venous system smooth muscle cell), which we believe actually denotes the kidney specific structure.

kidney afferent arteriole endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004639
subclass of: endothelial cell of arteriole
subclass of: endothelial cell of artery
subclass of: kidney afferent arteriole cell
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001039
in subset: cellxgene subset
in subset: human reference atlas

kidney afferent arteriole smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004639
subclass of: microcirculation associated smooth muscle cell
subclass of: kidney afferent arteriole cell
subclass of: kidney arteriole smooth muscle cell
imported from: cl.owl
database_cross_reference: KUPO:0001040

kidney efferent arteriole endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004640
subclass of: endothelial cell of arteriole
subclass of: kidney efferent arteriole cell
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001042
in subset: cellxgene subset
in subset: human reference atlas

kidney efferent arteriole smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004640
subclass of: microcirculation associated smooth muscle cell
subclass of: kidney efferent arteriole cell
subclass of: kidney arteriole smooth muscle cell
imported from: cl.owl
database_cross_reference: KUPO:0001043

kidney loop of Henle thick ascending limb epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney loop of Henle ascending limb epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001291
subclass of: kidney medulla cell
subclass of: kidney loop of Henle ascending limb epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001291
textual definition: An epithelial cell that is part of some loop of Henle thick ascending limb. It is known in some mammalian species that this cell may express the Na+-K+-2Cl− cotransporter (NKCC2) apically.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001049
in subset: cellxgene subset
in subset: human reference atlas

kidney loop of Henle thin ascending limb epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney loop of Henle ascending limb epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004193
subclass of: kidney inner medulla cell
subclass of: kidney loop of Henle ascending limb epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004193
textual definition: An epithelial cell that is part of some loop of Henle thin ascending limb.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001050
in subset: cellxgene subset
in subset: human reference atlas

kidney loop of Henle medullary thick ascending limb epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney loop of Henle ascending limb epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0006376
subclass of: kidney outer medulla cell
subclass of: kidney loop of Henle thick ascending limb epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0006376
textual definition: An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal medulla.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001051
in subset: cellxgene subset
in subset: human reference atlas

kidney loop of Henle cortical thick ascending limb epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney loop of Henle ascending limb epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0006854
subclass of: kidney loop of Henle thick ascending limb epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0006854
textual definition: An epithelial cell that is part of some loop of Henle thick ascending limb segment located in the renal cortex.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001052
in subset: cellxgene subset
in subset: human reference atlas

kidney loop of Henle thin descending limb epithelial cell
type: Class
equivalent class: Class
  intersection of: kidney loop of Henle descending limb epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005096
subclass of: epithelial cell of intermediate tubule
subclass of: kidney outer medulla cell
subclass of: kidney loop of Henle descending limb epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005096
textual definition: An epithelial cell that is part of some loop of Henle thin descending limb.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001054
in subset: cellxgene subset
in subset: human reference atlas

kidney outer medulla peritubular capillary cell
type: Class
equivalent class: Class
  intersection of: peritubular capillary endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0006341
subclass of: kidney outer medulla cell
subclass of: peritubular capillary endothelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0006341
imported from: cl.owl
database_cross_reference: KUPO:0001066

kidney cortex peritubular capillary cell
type: Class
equivalent class: Class
  intersection of: peritubular capillary endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0006851
subclass of: peritubular capillary endothelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0006851
imported from: cl.owl
database_cross_reference: KUPO:0001067

inner renal medulla vasa recta cell
type: Class
equivalent class: Class
  intersection of: vasa recta cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004776
subclass of: kidney inner medulla cell
subclass of: vasa recta cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004776
imported from: cl.owl
database_cross_reference: KUPO:0001069

outer renal medulla vasa recta cell
type: Class
equivalent class: Class
  intersection of: vasa recta cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004775
subclass of: kidney outer medulla cell
subclass of: vasa recta cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004775
imported from: cl.owl
database_cross_reference: KUPO:0001070

vasa recta ascending limb cell
type: Class
equivalent class: Class
  intersection of: vasa recta cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0009091
subclass of: vasa recta cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0009091
textual definition: A cell that is part of some vasa recta ascending limb.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001074
in subset: cellxgene subset
in subset: human reference atlas
comment: It is known in some mammalian species that this cell may express PV-1, a component of the fenestral diaphragm.

arcuate artery cell
type: Class
equivalent class: Class
  intersection of: kidney cortex artery cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001552
subclass of: kidney cortex artery cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001552
imported from: cl.owl
database_cross_reference: KUPO:0001078

interlobular artery cell
type: Class
equivalent class: Class
  intersection of: kidney cortex artery cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004723
subclass of: kidney cortex artery cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004723
imported from: cl.owl
database_cross_reference: KUPO:0001081

arcuate vein cell
type: Class
equivalent class: Class
  intersection of: kidney cortex vein cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004719
subclass of: kidney cortex vein cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004719
imported from: cl.owl
database_cross_reference: KUPO:0001085

interlobular vein cell
type: Class
equivalent class: Class
  intersection of: kidney cortex vein cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005168
subclass of: kidney cortex vein cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005168
imported from: cl.owl
database_cross_reference: KUPO:0001088

inner medulla vasa recta ascending limb cell
type: Class
equivalent class: Class
  intersection of: vasa recta ascending limb cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0009092
subclass of: inner renal medulla vasa recta cell
subclass of: vasa recta ascending limb cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0009092
imported from: cl.owl
database_cross_reference: KUPO:0001075

outer medulla vasa recta ascending limb cell
type: Class
equivalent class: Class
  intersection of: vasa recta ascending limb cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0009093
subclass of: outer renal medulla vasa recta cell
subclass of: vasa recta ascending limb cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0009093
imported from: cl.owl
database_cross_reference: KUPO:0001076

arcuate artery endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001552
subclass of: endothelial cell of artery
subclass of: arcuate artery cell
imported from: cl.owl
database_cross_reference: KUPO:0001079

arcuate artery smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001552
subclass of: kidney artery smooth muscle cell
subclass of: arcuate artery cell
imported from: cl.owl
database_cross_reference: KUPO:0001080

interlobulary artery endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004723
subclass of: endothelial cell of artery
subclass of: interlobular artery cell
imported from: cl.owl
database_cross_reference: KUPO:0001082

interlobulary artery smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004723
subclass of: kidney artery smooth muscle cell
subclass of: interlobular artery cell
imported from: cl.owl
database_cross_reference: KUPO:0001083

arcuate vein endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004719
subclass of: vein endothelial cell
subclass of: arcuate vein cell
imported from: cl.owl
database_cross_reference: KUPO:0001086

arcuate vein smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004719
subclass of: kidney venous system smooth muscle cell
subclass of: arcuate vein cell
imported from: cl.owl
database_cross_reference: KUPO:0001087

interlobulary vein endothelial cell
type: Class
equivalent class: Class
  intersection of: endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005168
subclass of: vein endothelial cell
subclass of: interlobular vein cell
imported from: cl.owl
database_cross_reference: KUPO:0001089

interlobulary vein smooth muscle cell
type: Class
equivalent class: Class
  intersection of: smooth muscle cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005168
subclass of: kidney venous system smooth muscle cell
subclass of: interlobular vein cell
imported from: cl.owl
database_cross_reference: KUPO:0001090

kidney collecting duct cell
type: Class
equivalent class: Class
  intersection of: kidney cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001232
subclass of: kidney cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001232
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000002625
textual definition: A cell that is part of a collecting duct of renal tubule.
imported from: cl.owl
database_cross_reference: KUPO:0001012
database_cross_reference: Wikipedia:Kidney_collecting_duct_cell
in subset: cellxgene subset

vasa recta descending limb cell
type: Class
equivalent class: Class
  intersection of: vasa recta cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0009202
subclass of: vasa recta cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0009202
textual definition: A cell that is part of some vasa recta descending limb.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001071
in subset: cellxgene subset
in subset: human reference atlas
comment: It is known in some mammalian species that this cell may express the urea transporter B.

inner medulla vasa recta descending limb cell
type: Class
equivalent class: Class
  intersection of: vasa recta descending limb cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0009089
subclass of: inner renal medulla vasa recta cell
subclass of: vasa recta descending limb cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0009089
imported from: cl.owl
database_cross_reference: KUPO:0001072

outer medulla vasa recta descending limb cell
type: Class
equivalent class: Class
  intersection of: vasa recta descending limb cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0009090
subclass of: outer renal medulla vasa recta cell
subclass of: vasa recta descending limb cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0009090
imported from: cl.owl
database_cross_reference: KUPO:0001073

renal interstitial pericyte
type: Class
equivalent class: Class
  intersection of: pericyte
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005215
subclass of: pericyte
subclass of: kidney interstitial cell
textual definition: A pericyte cell located in the kidney interstitium.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001104
in subset: cellxgene subset
in subset: human reference atlas

bladder cell
type: Class
equivalent class: Class
  intersection of: animal cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001255
subclass of: animal cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0001255
imported from: mondo.owl
database_cross_reference: KUPO:0001120
has_obo_namespace: cell

bladder urothelial cell
type: Class
equivalent class: Class
  intersection of: urothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004645
subclass of: urothelial cell
subclass of: bladder cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0004645
imported from: mondo.owl
database_cross_reference: KUPO:0001121
has_obo_namespace: cell

kidney collecting duct principal cell
type: Class
equivalent class: Class
  intersection of: renal principal cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001232
subclass of: renal principal cell
subclass of: kidney collecting duct epithelial cell
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000359
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000360
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000002625
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000006340
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000053828
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001128
in subset: cellxgene subset
in subset: human reference atlas

kidney collecting duct intercalated cell
type: Class
equivalent class: Class
  intersection of: renal intercalated cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001232
subclass of: renal intercalated cell
subclass of: kidney collecting duct epithelial cell
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000000760
subclass of: Restriction
  on property: cell has gene marker
  some values from: OGG_3000245972
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
database_cross_reference: KUPO:0001129
database_cross_reference: http://en.wikipedia.org/wiki/Collecting_duct_system#Intercalated_cells
in subset: cellxgene subset
in subset: human reference atlas

bone marrow hematopoietic cell
type: Class
equivalent class: Class
  intersection of: hematopoietic cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002371
subclass of: hematopoietic cell
subclass of: bone marrow cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0012429
textual definition: Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes.
imported from: cl.owl
imported from: mondo.owl
database_cross_reference: CALOHA:TS-2109
has_related_synonym: bone marrow hematopoietic cells
has_related_synonym: bone marrow poietic cells

microvascular endothelial cell
type: Class
equivalent class: Class
  intersection of: blood vessel endothelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0008339
subclass of: blood vessel endothelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0008339
textual definition: Any blood vessel endothelial cell that is part of a microvascular endothelium.
imported from: cl.owl
contributor: Q35563349
creation date: 2014-06-04T15:07:42Z
id: CL:2000008

peripheral nervous system neuron
type: Class
equivalent class: Class
  intersection of: neuron
  intersection of: Restriction
    on property: has soma location
    some values from: UBERON_0000010
subclass of: neuron
subclass of: Restriction
  on property: has soma location
  some values from: UBERON_0000010
textual definition: A neuron that is part of a peripheral nervous system.
imported from: cl.owl
contributor: Q35563349
creation date: 2014-06-25T02:28:17Z
database_cross_reference: FMA:84664
has_exact_synonym: PNS neuron
has_exact_synonym: peripheral neuron
id: CL:2000032
in subset: cellxgene subset

kidney collecting duct beta-intercalated cell
type: Class
equivalent class: Class
  intersection of: renal beta-intercalated cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0004203
subclass of: renal beta-intercalated cell
subclass of: kidney cortex collecting duct intercalated cell
textual definition: A renal beta-intercalated cell that is part of the cortical collecting duct. The medullary collecting duct does not contain the renal beta-intercalated cell type.
imported from: cl.owl
date: 2022-09-14T16:19:11Z
has_exact_synonym: B-IC
has_exact_synonym: kidney collecting duct intercalated cell type B

pronephric podocyte
type: Class
equivalent class: Class
  intersection of: podocyte
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0002120
subclass of: podocyte
subclass of: Restriction
  on property: part of
  some values from: UBERON_0002120
textual definition: A specialized epithelial cell that contains "feet" that interdigitate with the "feet" of other glomerular epithelial cells in the pronephros.
imported from: cl.owl
date: 2022-03-11T14:38:32Z
has_exact_synonym: pronephric glomerular visceral epithelial cell

epithelial cell of proximal tubule segment 1
type: Class
subclass of: epithelial cell of proximal tubule
textual definition: Epithelial cell that is part of segment 1 (S1) of the proximal tubule epithelium.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-05-10T13:14:00Z
has_exact_synonym: epithelial cell of segment 1 of proximal tubule
in subset: cellxgene subset
in subset: human reference atlas

epithelial cell of proximal tubule segment 2
type: Class
subclass of: epithelial cell of proximal tubule
textual definition: Epithelial cell that is part of segment 2 (S2) of the proximal tubule epithelium.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-05-10T13:26:13Z
has_exact_synonym: epithelial cell of segment 2 of proximal tubule
in subset: human reference atlas

epithelial cell of proximal tubule segment 3
type: Class
subclass of: epithelial cell of proximal tubule
textual definition: Epithelial cell that is part of segment 3 (S3) of the proximal tubule epithelium.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-05-10T13:31:06Z
has_exact_synonym: epithelial cell of segment 3 of proximal tubule
in subset: cellxgene subset
in subset: human reference atlas

kidney loop of Henle short descending thin limb epithelial cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005099
subclass of: kidney loop of Henle thin descending limb epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005099
textual definition: Epithelial cell of the descending thin limb of the short loop (cortical) nephron limited to the outer medulla (mainly inner strip). It is known in some mammalian species that the short descending limb of the loop of Henle selectively expresses the serine protease Corin, the homeobox TF Uncx, and the urea channel Slc14a2.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-05-13T11:00:29Z
has_exact_synonym: epithelial cell of the descending thin limb of the short loop of Henle
in subset: human reference atlas

kidney loop of Henle long descending thin limb outer medulla epithelial cell
type: Class
subclass of: kidney loop of Henle thin descending limb epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005100
textual definition: Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the outer medulla (inner stripe). It is known in some mammalian species that the long descending limb of the loop of Henle in the outer medulla selectively expresses the secreted activin-antagonist protein follistatin (Fst), the GPI-linked adhesion protein Cdh13, and the protein kinase Stk32a.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-05-13T11:11:07Z
has_exact_synonym: epithelial cell of the outer medulla of the long descending limb of the loop of Henle
in subset: human reference atlas

kidney loop of Henle long descending thin limb inner medulla epithelial cell
type: Class
subclass of: kidney loop of Henle thin descending limb epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005100
textual definition: Epithelial cell of the descending thin limb of the long loop (juxtamedullary) nephron that spans the inner medulla. It is known in some mammalian species that the long descending limb of the loop of Henle in the inner medulla selectively expresses the nuclear receptor Nr2e3, the Ig kappa chain Igkc, and the secreted protein dermokine (Dmkn). SLC14A2, which expresses a urea transporter, is also expressed in the inner medulla.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-05-13T11:16:54Z
has_exact_synonym: epithelial cell of the inner medulla of the long descending limb of the loop of Henle
in subset: human reference atlas

kidney collecting duct alpha-intercalated cell
type: Class
equivalent class: Class
  intersection of: renal alpha-intercalated cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0001232
subclass of: renal alpha-intercalated cell
subclass of: kidney collecting duct intercalated cell
textual definition: A renal alpha-intercalated cell that is part of the collecting duct of the renal tubule.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-05-31T11:15:10Z
has_exact_synonym: kidney collecting duct intercalated cell type A
in subset: human reference atlas

epithelial cell of early distal convoluted tubule
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005101
subclass of: kidney distal convoluted tubule epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005101
textual definition: An epithelial cell located in the early distal convoluted tubule.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-06-21T12:47:48Z
has_broad_synonym: DCT1 cell
in subset: human reference atlas

epithelial cell of late distal convoluted tubule
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005102
subclass of: kidney distal convoluted tubule epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005102
textual definition: An epithelial cell located in the late distal convoluted tubule.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-06-21T13:51:46Z
has_broad_synonym: DCT2 cell
in subset: human reference atlas
comment: Although mineralocorticoid receptors are expressed throughout the entire [distal convoluted tubule], the DCT2 is sensitive to the actions of aldosterone, because it expresses an enzyme called 11-β hydroxysteroid dehydrogenase 2 (11-βHSD2)

kidney connecting tubule principal cell
type: Class
equivalent class: Class
  intersection of: renal principal cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005097
subclass of: renal principal cell
subclass of: kidney connecting tubule epithelial cell
textual definition: A renal principal cell located in the connecting tubule.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-06-27T15:25:10Z
in subset: cellxgene subset
in subset: human reference atlas

kidney connecting tubule intercalated cell
type: Class
equivalent class: Class
  intersection of: renal intercalated cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005097
subclass of: renal intercalated cell
subclass of: kidney connecting tubule epithelial cell
textual definition: A renal intercalated cell that is part of the renal connecting tubule.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-06-29T11:25:22Z
in subset: human reference atlas

kidney connecting tubule alpha-intercalated cell
type: Class
equivalent class: Class
  intersection of: renal alpha-intercalated cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005097
subclass of: renal alpha-intercalated cell
subclass of: kidney connecting tubule intercalated cell
textual definition: A renal alpha-intercalated cell that is part of the renal connecting tubule.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-06-29T12:48:43Z
has_exact_synonym: connecting tubule A-IC
has_exact_synonym: kidney connecting tubule intercalated cell type A
in subset: human reference atlas

kidney connecting tubule beta-intercalated cell
type: Class
equivalent class: Class
  intersection of: renal beta-intercalated cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005097
subclass of: renal beta-intercalated cell
subclass of: kidney connecting tubule intercalated cell
textual definition: A renal beta-intercalated cell that is part of the renal connecting tubule.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-06-29T14:31:18Z
has_exact_synonym: connecting tubule B-IC
has_exact_synonym: kidney connecting tubule intercalated cell type B
in subset: human reference atlas

renal medullary fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005211
subclass of: kidney medulla interstitial cell
subclass of: kidney interstitial fibroblast
textual definition: A fibroblast that is located in the renal medulla interstitium.
imported from: cl.owl
present_in_taxon: NCBITaxon 9606
date: 2022-07-05T12:13:40Z
has_exact_synonym: kidney medullary fibroblast
in subset: human reference atlas
comment: It has been noted that inner medullary fibroblasts are involved in the regulation of water and electrolyte homeostasis.

renal cortical fibroblast
type: Class
equivalent class: Class
  intersection of: fibroblast
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005270
subclass of: kidney cortex interstitial cell
subclass of: kidney interstitial fibroblast
textual definition: A fibroblast that is located in the renal cortical interstitium.
imported from: cl.owl
date: 2022-07-05T15:50:17Z
has_exact_synonym: kidney cortical fibroblast
comment: Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix and maintenance of renal tissue architecture. They additionally have an endocrine function in the production of epoetin.

interstitial cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0005169
subclass of: cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0005169
textual definition: Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. "Interstitial cell" is a morphological term and refers to a variety of cells with differing origins and phenotypes.
imported from: cl.owl
date: 2022-11-30T14:35:08Z

CD24-positive, CD-133-positive, vimentin-positive proximal tubular cell
type: Class
subclass of: epithelial cell of proximal tubule
subclass of: Restriction
  on property: part of
  some values from: UBERON_0008404
subclass of: Restriction
  on property: expresses
  some values from: PR_000001786
subclass of: Restriction
  on property: expresses
  some values from: PR_000001932
subclass of: Restriction
  on property: expresses
  some values from: PR_000017298
textual definition: A CD24-positive, CD-133-positive, vimentin-positive cell found scattered throughout a renal proximal tubule and that may participate in tubular regeneration. Compared to other proximal tubular cell types, this cell contains less cytoplasm, fewer mitochondria and no brush border.
imported from: cl.owl
date: 2023-03-07T14:17:39Z
has_broad_synonym: CD133+CD24+CD106- tubular cell
has_broad_synonym: CD24+CD133+ tubular cell
has_broad_synonym: CD24-positive tubular cell
comment: After acute tubular injury, this cell type becomes more numerous. In healthy rat kidneys, this cell is not detectable, whereas after unilateral ureteral obstruction (renal injury), it may appear de novo, arguing against the notion that this cell type represents a pre-existing progenitor cell population. In at least one study, data indicate that this cell type represents transiently dedifferentiated tubular cells involved in regeneration.

ureteric bud cell
type: Class
equivalent class: Class
  intersection of: epithelial cell
  intersection of: Restriction
    on property: part of
    some values from: UBERON_0000084
subclass of: duct epithelial cell
subclass of: kidney epithelial cell
subclass of: Restriction
  on property: part of
  some values from: UBERON_0000084
subclass of: Restriction
  on property: participates in
  some values from: GO_2001013
textual definition: An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion.
imported from: cl.owl
contributor: https://orcid.org/0000-0002-1425-877X
date: 2023-10-13T11:22:42Z
has_related_synonym: UB cell

perivascular cell
type: Class
equivalent class: Class
  intersection of: cell
  intersection of: Restriction
    on property: adjacent to
    some values from: UBERON_0002049
subclass of: cell
subclass of: Restriction
  on property: adjacent to
  some values from: UBERON_0002049
textual definition: A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics.
imported from: cl.owl
imported from: hp.owl
contributor: https://orcid.org/0000-0001-6677-8489
date: 2023-08-22T13:40:28Z

clinical measurement
type: Class
subclass of: IAO_0000109
imported from: cmo.owl
def: A quantitative or qualitative value which is the result of an act of assessing a morphological or physiological state or property in a single individual or sample or a group of individuals or samples, based on direct observation or experimental manipulation.

cardiovascular measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
def: Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart and/or blood vessels.

heart rate
type: Class
subclass of: heart measurement
imported from: cmo.owl
def: The number of contractions of the cardiac ventricles per unit of time.

blood pressure measurement
type: Class
subclass of: cardiovascular measurement
imported from: cmo.owl
def: Measurement of the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood.
has related synonym: Not4Curation

systolic blood pressure
type: Class
subclass of: blood pressure measurement
imported from: cmo.owl
def: The maximum arterial pressure within the cardiac cycle, i.e. at the point at which the heart is in its maximal state of contraction. This is the time when the blood is forced from the ventricles of the heart into the pulmonary artery and the aorta.

diastolic blood pressure
type: Class
subclass of: blood pressure measurement
imported from: cmo.owl
def: The minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood.

left ventricular diastolic blood pressure
type: Class
subclass of: diastolic blood pressure
imported from: cmo.owl
def: The minimum pressure in the heart left ventricle, usually at the point at which the heart is in a state of relaxation and expansion and the ventricles fill with blood.

left ventricular systolic blood pressure
type: Class
subclass of: systolic blood pressure
imported from: cmo.owl
def: Measurement of the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta.

calculated blood pressure
type: Class
subclass of: blood pressure measurement
imported from: cmo.owl
def: A blood pressure measurement which has been normalized or adjusted by a mathematical process or computation. Blood pressure is the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood.
has related synonym: Not4Curation

mean arterial blood pressure
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
def: The average blood pressure within an artery over a specified period of time. It is often calculated using the formula of one third systolic pressure plus two thirds diastolic pressure, or alternatively, using the formula diastolic pressure plus 1/3 of the difference between systolic pressure and diastolic pressure (i.e. 1/3 pulse pressure).

developed blood pressure
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
def: A calculated value for the difference between the systolic blood pressure and the diastolic blood pressure at a given point in time when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

body temperature
type: Class
subclass of: clinical measurement
imported from: cmo.owl
def: The level of heat in an organism.

heart morphological measurement
type: Class
subclass of: organ morphological measurement
subclass of: heart measurement
imported from: cmo.owl
def: A measurement of the physical form or structure of the heart, the chambered, muscular organ in vertebrates that pumps blood received from the veins into the arteries, thereby maintaining the flow of blood through the entire circulatory system.
comment: This is the term which was just "heart measurement". Since it was under body morphological measurement it seemed to clearly refer to a morphological measurement. I made this term more specific so that another term for "heart measurement" could be added to the ontology above it which would also be a parent to other non-morphological heart-related terms. JRS 2-15-2012.

heart weight
type: Class
subclass of: heart morphological measurement
imported from: cmo.owl
def: The heaviness of the heart (the central cardiac muscle which maintains the circulation of the blood) or the degree to which it is drawn to the earth by gravity.

left ventricular developed pressure
type: Class
subclass of: developed blood pressure
subclass of: CMO_0001744
imported from: cmo.owl
def: A calculated measurement of the difference between the systolic pressure and the diastolic pressure in the heart left ventricle at a given point in time in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

body morphological measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
def: Measurement of the structure or forms of the entire body or parts of the body of an organism.
has related synonym: anthropometric measurement
has related synonym: morphometry

blood chemistry measurement
type: Class
subclass of: blood measurement
imported from: cmo.owl
def: A quantification of a parameter of the chemical composition of blood.
has related synonym: blood molecular composition measurement

calculated differential white blood cell count
type: Class
subclass of: blood differential white blood cell count
subclass of: CMO_0002341
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:32:58Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of one or more of the various, specific types of leukocytes present in a sample of blood for which a total white blood cell count was taken, usually 1 cubic mm of peripheral venous blood.
has related synonym: calculated blood differential WBC count
has related synonym: calculated blood differential leukocyte count

blood hemoglobin level
type: Class
subclass of: blood protein measurement
imported from: cmo.owl
def: The amount of hemoglobin in a specific volume of blood, expressed as grams per deciliter of whole blood in humans.
has exact synonym: blood haemoglobin level

white blood cell count
type: Class
subclass of: CMO_0001865
subclass of: CMO_0002341
imported from: cmo.owl
def: The number of white blood cells in a specified volume of blood.
has related synonym: leukocyte count
has related synonym: white corpuscle count

blood protein measurement
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
def: Any measurement involving the amount, composition or type of protein, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, in blood.

platelet count
type: Class
subclass of: blood cell measurement
imported from: cmo.owl
def: The number of platelets (thrombocytes) in a specified volume of blood, usually expressed as platelets per cubic millimeter of whole blood.

blood measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
def: A measurement of the blood, it's contents, cells or other factors contained within the blood.

blood cell measurement
type: Class
subclass of: blood measurement
subclass of: cell measurement
imported from: cmo.owl
def: A value resulting from the quantification of a morphological or physiological parameter of blood cells, i.e. cells native to the circulation, including those of erythroid, lymphoid, myeloid and monocytic lineages. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning.

blood urea nitrogen level
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
def: The level of urea in the blood in terms of nitrogen content; converted to urea concentration by multiplying by 60/28 or 2.14. Urea is the chief nitrogenous end product of protein metabolism in whole blood. Urea is formed in the liver from amino acids and from ammonia compounds and can be found in urine, blood, and lymph.
has related synonym: BUN level

blood lipid measurement
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
def: Any value resulting from the quantification of a morphological or physiological parameter of a blood-derived lipid, any of a structurally diverse group of organic compounds found in blood that are insoluble in water but soluble innonpolar solvents that, among other biological functions, serve as a source of fuel and are an important constituent of cell structure.

blood total cholesterol level
type: Class
subclass of: blood lipoprotein level
subclass of: CMO_0002280
imported from: cmo.owl
def: Measurement of the entire amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, without taking into account any association with other molecules such as lipoproteins, in a specified volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them.
has related synonym: blood TC level

blood high density lipoprotein cholesterol level
type: Class
subclass of: CMO_0002696
imported from: cmo.owl
def: Measurement of the amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, carried in high-density lipoprotein (HDL) molecules in a specified volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. HDL is the smallest of the major lipoprotein particles, complex molecules that consist of a protein membrane surrounding a core of lipids. The HDL class of lipoproteins, specifically the subtypes of HDL2 and HDL3, have densities between 1.063 and 1.210 g/ml.
has related synonym: blood HDL level
has related synonym: blood HDL-C
comment: Values for density ranges of the lipoprotein classes are approximate. The classes may be defined differently by different researchers, in part because class definitions depend on the number of subclasses into which the lipoprotein fractions are divided.

blood low density lipoprotein cholesterol level
type: Class
subclass of: CMO_0002696
imported from: cmo.owl
def: Measurement of the amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, carried in low-density lipoprotein (LDL) molecules in a specified volume of blood, the fluid that circulates through the heart, arteries, capillaries and veins carrying nutrients and oxygen to the body tissues and metabolites away from them. LDL constitute a class of relatively large, heterogeneous lipoprotein particles, complex molecules that consist of a protein membrane surrounding a core of lipids. The LDL class of lipoproteins has a density between 1.019 and 1.063 g/ml. In some animal species, such as canine and rodents, this may overlap with the HDL1 class and be designated LDL/HDL1.
has related synonym: blood LDL level
has related synonym: blood LDL-C level
comment: Values for density ranges of the lipoprotein classes are approximate. The classes may be defined differently by different researchers, in part because class definitions depend on the number of subclasses into which the lipoprotein fractions are divided.

plasma total protein level
type: Class
subclass of: blood protein measurement
imported from: cmo.owl
def: Measurement of the total amount of all proteins, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, found in a specific volume of plasma, the fibrinogen-containing fluid portion of the blood in which the particulate components are suspended.

blood electrolyte measurement
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
def: A quantification of one or more mineral salts found in the blood in the form of electrically charged ions.

blood enzyme activity level
type: Class
subclass of: blood protein measurement
imported from: cmo.owl
def: Any quantitation of the catalytic effect exerted by an enzyme in a specified sample of blood. An enzyme is a protein that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reaction(s).
has related synonym: Not4Curation

organ morphological measurement
type: Class
subclass of: body morphological measurement
subclass of: organ measurement
imported from: cmo.owl
def: A measurement of the physical form and structure of an organ.
comment: This is the term which used to be just "organ measurement". Since it was under body morphological measurement, it clearly referred to a morphological measurement. Because a term for organ measurement was needed that was not morphological, and since this one already had annotations, I changed the term while keeping the ID and location in the ontology the same. JRS 2-15-2012.

heart wet weight
type: Class
subclass of: heart weight
imported from: cmo.owl
def: The weight of the heart after removal from the body but without desiccation.

heart dry weight
type: Class
subclass of: heart weight
imported from: cmo.owl
def: The weight of the heart after desiccation.

heart left ventricle wet weight
type: Class
subclass of: heart wet weight
subclass of: heart left ventricle weight
imported from: cmo.owl
def: The weight of the lower left chamber of the heart, which pumps oxygenated blood through the aorta into the systemic arteries, after removal from the body and separation from the rest of the heart but without desiccation.
has alternative id: CMO_0000655

heart right ventricle wet weight
type: Class
subclass of: heart wet weight
subclass of: heart right ventricle weight
imported from: cmo.owl
def: The weight of the lower right chamber of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, after removal from the body and separation from the rest of the heart but without desiccation.
has alternative id: CMO_0000624

calculated heart weight
type: Class
subclass of: heart weight
imported from: cmo.owl

heart weight to body weight ratio
type: Class
subclass of: calculated heart weight
imported from: cmo.owl
def: A calculated value in which the weight of the heart, the chambered, muscular organ in vertebrates that pumps blood received from the veins into the arteries, thereby maintaining the flow of blood through the entire circulatory system, is divided by the total weight of the body, and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and, by extension, to the size of the organism.

heart weight as percentage of body weight
type: Class
subclass of: calculated heart weight
imported from: cmo.owl
def: A calculated value in which the weight of the heart, the chambered, muscular organ in vertebrates that pumps blood received from the veins into the arteries, thereby maintaining the flow of blood through the entire circulatory system, is presented as percentage of the total weight of the body, thus normalizing it to body weight.

aorta weight
type: Class
subclass of: CMO_0001475
imported from: cmo.owl
def: The weight of the aorta, the main trunk from which the arterial system proceeds. Weight is the heaviness or degree to which a body is drawn to the earth by gravity.

blood vessel measurement
type: Class
subclass of: cardiovascular measurement
imported from: cmo.owl
def: Any quantification of a morphological or physiological parameter of one or more blood vessels, the network of muscular tubes that carry blood through the body.

renal/urinary measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl

kidney weight
type: Class
subclass of: kidney morphological measurement
imported from: cmo.owl
def: The weight of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.

right kidney wet weight
type: Class
subclass of: single kidney wet weight
imported from: cmo.owl
def: The weight of the right kidney, the organ which lies on the right side of the body from the perspective of the subject and functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation.

left kidney wet weight
type: Class
subclass of: single kidney wet weight
imported from: cmo.owl
def: The weight of the left kidney, the organ which lies on the left side of the body from the perspective of the subject and functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation.

single kidney wet weight
type: Class
subclass of: kidney wet weight
imported from: cmo.owl
def: The weight of a single kidney, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation.
has exact synonym: individual kidney wet weight

both kidneys wet weight
type: Class
subclass of: kidney wet weight
imported from: cmo.owl
def: The weight of both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation.

kidney morphological measurement
type: Class
subclass of: organ morphological measurement
subclass of: kidney measurement
imported from: cmo.owl
def: Measurement of the physical form or structure of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.

heart right ventricle weight to left ventricle weight ratio
type: Class
subclass of: calculated heart left ventricle weight
subclass of: calculated heart right ventricle weight
imported from: cmo.owl
created by: mshimoyama
creation date: 2009-12-17T08:17:35Z
def: A calculated value which compares the weight of the right ventricle, the lower chamber of the right side of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, with the weight of the left ventricle, the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body, and presents it as a ratio.

blood granulocyte count
type: Class
subclass of: blood differential white blood cell count
imported from: cmo.owl
created by: mshimoyama
creation date: 2009-12-17T08:22:51Z
def: The number of granulocytes (polymorphonuclear leukocytes) in a specified volume of blood, usually 1 cubic millimeter.

blood lipoprotein level
type: Class
subclass of: CMO_0002690
imported from: cmo.owl
created by: mshimoyama
creation date: 2009-12-17T10:21:58Z
def: The amount of lipoproteins, any of a group of conjugated proteins that have at least one lipid component, in a specific volume of blood.

urine creatinine level
type: Class
subclass of: urine measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2009-12-17T11:00:47Z
def: Measurement of the amount of creatinine in a specified sample of urine, the fluid waste product excreted by the kidneys. Creatinine is a nitrogenous compound formed in muscle as the end product of creatine metabolism. Blood and urine tests for creatinine are used as diagnostic indicators of kidney function and muscle mass.
xref: CHEBI_16737

muscle morphological measurement
type: Class
subclass of: body morphological measurement
subclass of: muscle measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-24T01:24:08Z
def: Any measurement of the physical form or structure of the skeletal, smooth and/or heart muscles of the body.

urine albumin level
type: Class
subclass of: urine protein level
imported from: cmo.owl
created by: mshimoyama
creation date: 2009-12-17T11:01:46Z
def: The amount of albumin in a specified volume of urine. Urine albumin levels which are above normal but not detectable with routine protein testing are referred to as microalbuminuria.
has related synonym: urine microalbumin level

both kidneys wet weight as percentage of body weight
type: Class
subclass of: both kidneys wet weight
subclass of: CMO_0001952
imported from: cmo.owl
created by: RNigam
creation date: 2010-05-17T01:48:45Z
def: A calculated measurement in which the weight after removal from the body but without desiccation of both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is divided by the total weight of the body and presented as a percentage, thus normalizing it to body weight.

calculated kidney weight
type: Class
subclass of: kidney weight
imported from: cmo.owl
created by: RNigam
creation date: 2010-05-25T04:01:05Z
def: Any measurement that has been normalized, adjusted or derived by a mathematical process or computation, of the weight of one or both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.
has related synonym: Not4Curation

kidney wet weight
type: Class
subclass of: kidney weight
imported from: cmo.owl
created by: RNigam
creation date: 2010-05-25T04:11:18Z
def: The weight of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, after removal from the body but without desiccation.

kidney dry weight
type: Class
subclass of: kidney weight
imported from: cmo.owl
created by: RNigam
creation date: 2010-05-25T04:11:36Z
def: The weight after desiccation of one or both kidneys, the organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes.

blood vessel diameter
type: Class
subclass of: CMO_0001997
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:05:26Z
def: The length of a line which crosses a transverse view of a blood vessel, passing through its center and ending on either side at either the inner surface or outer surface of the blood vessel wall.

ejection fraction
type: Class
subclass of: CMO_0002502
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:06:25Z
def: Percentage of blood pumped out of the left ventricle with each heart beat.
has related synonym: heart left ventricle ejection fraction

end-systolic volume
type: Class
subclass of: CMO_0002502
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:08:28Z
def: Volume of blood left in a ventricle at end of contraction.

circulation measurement
type: Class
subclass of: cardiovascular measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:38:29Z
def: Any measurement of the movement of blood through the heart and blood vessels.
has related synonym: blood flow measurement

blood flow rate
type: Class
subclass of: circulation measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:38:42Z
def: The volume of blood flowing through a vessel or organ per unit of time.

cardiac output measurement
type: Class
subclass of: CMO_0002502
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:51:29Z
def: The volume of blood pumped from the right or left ventricle per minute, also used to calculate - stroke volume X heart rate.

arterial blood flow rate
type: Class
subclass of: blood flow rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:56:23Z
def: The volume of blood flowing through an artery per unit time.

venous blood flow rate
type: Class
subclass of: blood flow rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T09:56:38Z
def: The volume of blood passing through a vein per unit time.

vessel shear stress measurement
type: Class
subclass of: circulation measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T10:04:04Z
def: Movement of blood along the solid wall of a vessel, often represented by the Hagen-Poiseuille equation.

in vitro vessel shear stress
type: Class
subclass of: vessel shear stress measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T10:51:43Z

in vivo vessel shear stress
type: Class
subclass of: vessel shear stress measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T10:52:06Z

activated partial thromboplastin time
type: Class
subclass of: blood measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T11:20:31Z
def: The time needed for plasma to form a fibrin clot after the addition of calcium and a phospholipid reagent. It is used to evaluate the intrinsic clotting system.

blood vessel dilation measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T02:02:16Z
has related synonym: vasodilation measurement

lumen diameter at maximum dilation expressed as percent of baseline
type: Class
subclass of: blood vessel dilation measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T02:02:34Z

blood vessel constriction measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T02:34:30Z
has related synonym: vasoconstriction measurement

lumen diameter at maximum constriction expressed as percent of baseline
type: Class
subclass of: blood vessel constriction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T02:35:20Z

systemic vascular resistance (SVR)
type: Class
subclass of: circulation measurement
subclass of: blood vessel resistance measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T02:41:52Z
def: Resistance to blood flow by blood vessels throughout the body, the degree to which the blood vessels impede the flow of blood, often calculated as SVR equal to the difference between mean arterial blood pressure(MAP) and central venous pressure(CVP) divided by cardiac output(CO).

end-diastolic volume
type: Class
subclass of: CMO_0002502
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-10T03:56:38Z
def: Volume of blood in ventricle immediately before a contraction.

stroke volume
type: Class
subclass of: CMO_0002502
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-11T01:32:10Z
def: Volume of blood pumped from one ventricle of the heart with each beat, calculated by subtracting the volume of blood in the ventricle at the end of a beat (end-systolic volume) from the volume of blood just prior to the beat (end-diastolic volume).

cell measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:30:36Z
def: Any quantification of a morphological or physiological parameter of one or more cells. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning.

cardiomyocyte count
type: Class
subclass of: heart morphological measurement
subclass of: cell measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:30:50Z
def: Number of cells of muscular tissue in the heart in a specified sample size.

blood vessel endothelial cell count
type: Class
subclass of: blood vessel endothelium measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:33:11Z
def: The enumeration, i.e. measurement of the total number, of the specialized liner cells that form an interface between the circulating blood and the rest of the vessel wall in a specified sample of blood vessel, any one of the network of muscular tubes that carry blood through the body.
has exact synonym: blood vessel endothelial cell number
has exact synonym: vascular endothelial cell count

heart electrical conduction measurement
type: Class
subclass of: heart measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:36:15Z
def: Any measurement of components of the Electrical conduction system of the heart.The electrical conduction system of the heart transmits signals generated usually by the sinoatrial node to cause contraction of the heart muscle.

RR interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:39:30Z
def: Interval between an R wave and the next R wave of successive heart beats, inverse of the heart rate.
has related synonym: RR_Interval

PR interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:40:52Z
def: Time between the beginning of the P wave to the beginning of the QRS complex, reflects the time the electrical impulse takes to travel from the sinus node through the AVE node and entering the ventricles, used as an estimate of AV node function.
has related synonym: PR_Interval

ST interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:43:21Z
def: The time between the J point ( the point at which the QRS complex finishes and the ST segment begins) to the end of the T wave.
has related synonym: ST_Interval

QT interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:45:44Z
def: An interval measured from the onset of the QRS wave complex to the offset of the T wave.
has related synonym: QT_Interval

heart wall thickness
type: Class
subclass of: heart morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:53:08Z

aorta wall thickness
type: Class
subclass of: artery wall thickness
subclass of: CMO_0001641
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T10:54:17Z
def: The depth of the wall of the aorta, the main trunk from which the arterial system proceeds.
has exact synonym: aortic wall thickness

heart posterior wall thickness
type: Class
subclass of: heart wall thickness
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T11:13:15Z
def: The thickness or depth of the dorsal/posterior wall of the heart. The dorsal wall is the portion of the heart muscle which is closest to the spine and farthest from the chest wall of the organism.
has related synonym: heart dorsal wall thickness

heart left ventricle posterior wall thickness
type: Class
subclass of: heart posterior wall thickness
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T11:15:28Z
def: The thickness or depth (i.e. the measurement of the two-dimensional extent of the distance between the inner and outer surfaces) of the dorsal/posterior wall of the left ventricle of the heart. The dorsal wall is the portion of the muscle enclosing the ventricle which is closest to the spine and farthest from the chest wall of the organism. The left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body.
has related synonym: heart left ventricle dorsal wall thickness
comment: Note that "left" in this context refers to the perspective of the organism, not that of the observer.

heart right ventricle posterior wall thickness
type: Class
subclass of: heart posterior wall thickness
subclass of: heart right ventricle morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T11:15:42Z
def: The thickness or depth of the dorsal/posterior wall of the right ventricle of the heart. The dorsal wall is the portion of the muscle enclosing the ventricle which is closest to the spine and farthest from the chest wall of the organism.
has related synonym: heart right ventricle dorsal wall thickness

urine measurement
type: Class
subclass of: renal/urinary measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:26:05Z
def: Any measurement of urine, the fluid waste product excreted by the kidneys, or its components.

urine specific gravity
type: Class
subclass of: urine measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:27:01Z
def: Measure of the concentration of particles in the urine.
has related synonym: urine density

P wave amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:38:44Z
def: The magnitude of the P wave, the initial deflection of the cardiac cycle representing excitation of the atria as presented in an electrocardiogram.

P wave duration
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:39:11Z
def: The time from start to finish of the P wave , in the electrocardiograph illustrating the initial deflection of the cardiac cycle, representing the excitation of the atria.

Q wave depth
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:39:35Z
def: The distance to the lowest part of the Q wave which shows the initial downward deflection related to the initial phase of depolarization of the ventricular myocardium and the depolarization of the interventricular septum as measured by electrocardiograph.

Q wave duration
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:39:55Z
def: The time from start to finish of the Q wave which illustrates the initial downward deflection related to the initial phase of depolarization of the ventricular myocardium and the depolarization of the interventricular septum as measured by an electrocardiograph.

QRS duration
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:40:13Z
def: The time from start to finish of the QRS interval as calculated from a set of measurements taken from the beginning of the QRS complex to the end of the QRS complex representing the time it takes for ventricles to depolarize.

QRS amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:40:30Z
def: The magnitude of the portion of the electrocardiograph comprising the Q, R, and S waves which together represent ventricular depolarization.

QTC interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:40:52Z
def: QT interval corrected for heart rate calculated by the QT interval divided by the square root of the interval from one QRS complex to the onset of the next QRS complex measured in seconds.

R wave amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:41:09Z
def: The magnitude of the R wave, which is the initial upward deflection of the QRS complex following the Q wave representing early depolarization of the ventricles as illustrated by an electrocardiograph.

R wave duration
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:41:26Z
def: The time from start to finish of the R wave, the initial upward deflection of the QRS complex following the Q wave which represents early depolarization of the ventricles as illustrated in and electrocardiograph.

S wave amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:41:54Z
def: The magnitude of the S wave, the downward deflection of the QRS complex following the R wave representing late depolarization of the ventricles as illustrated in an electrocardiograph.

S wave duration
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:42:07Z
def: The time from start to finish of the S wave which is the downward deflection of the QRS complex following the R wave representing late depolarization as illustrated by an electrocardiograph.

ST amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:42:27Z

ST slope
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:42:46Z

ST wave displacement
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:43:04Z

T wave amplitude
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T12:43:21Z
def: The magnitude of the T wave, the deflection following the QRS complex representing repolarization of the ventricles as illustrated by and electrocardiograph.

PP interval
type: Class
subclass of: heart electrical conduction measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-17T03:09:47Z
def: An interval measured from the onset of the P wave in one PQRST wave complex to the onset of the P wave in the following PQRST wave complex.
has related synonym: PP_Interval

pulse pressure
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-06-25T01:54:10Z
def: The difference between systolic and diastolic blood pressures, i.e. the difference between the maximal arterial pressure and minimal arterial pressure during the cardiac cycle.

pulse
type: Class
subclass of: cardiovascular measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-08-04T10:37:40Z
def: The count of the rhythmic contractions and expansions of an artery due to the surge of blood from the beat of the heart.

heart atrium morphological measurement
type: Class
subclass of: heart morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:30:15Z
def: Measurement of the physical form or structure of either the right or the left upper chamber of the heart that receives blood from the veins and forces it into a ventricle.

left atrium weight
type: Class
subclass of: CMO_0001483
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:30:28Z
def: The weight of the left atrium of the heart, the upper chamber on the left which empties into the lower chamber. Weight is the heaviness or degree to which a body is drawn toward the earth by gravity.

right atrium weight
type: Class
subclass of: CMO_0001484
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:30:45Z
def: The weight of the right atrium, the upper right chamber of the heart which empties into the lower right chamber, i.e. the right ventricle. Weight is the heaviness or degree to which a body is drawn to the earth by gravity.

left atrium volume
type: Class
subclass of: CMO_0001483
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:30:56Z
def: A measure of the capacity of the left heart atrium, the upper left chamber which empties into the lower heart chamber.

right atrium volume
type: Class
subclass of: CMO_0001484
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:31:06Z
def: A measure of the three dimensional capacity of the right atrium of the heart, the upper right chamber which empties into the lower right chamber, i.e. the right ventricle.

heart ventricle morphological measurement
type: Class
subclass of: heart morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-09-01T08:31:46Z
def: Any measurement of the physical form or structure of one or both ventricles of the heart, that is, the lower chambers of the heart that pump blood away from the heart either to the lungs to be oxygenated or, once oxygenated, to the rest of the body.

both kidneys wet weight to body weight ratio
type: Class
subclass of: both kidneys wet weight
subclass of: CMO_0001952
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-09-21T01:41:55Z
def: A calculated measurement in which the weight after removal from the body but without desiccation of both kidneys, the paired organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is divided by the total weight of the body and presented as a ratio, fraction or quotient, thus normalizing it to body weight.

serum triglyceride level
type: Class
subclass of: blood lipid measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-11-12T09:44:31Z
def: The amount of triglycerides in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Triglycerides are any of a group of lipids that are esters formed from one molecule of glycerol and three molecules of one or more fatty acids, are widespread in adipose tissue, and commonly circulate in the blood in the form of lipoproteins.

serum total cholesterol level
type: Class
subclass of: blood total cholesterol level
subclass of: CMO_0002281
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-11-12T09:46:59Z
def: Measurement of the entire amount of cholesterol, a eukaryotic sterol that in higher animals is the precursor of bile acids and steroid hormones and a key constituent of cell membranes, without taking into account any association with other molecules such as lipoproteins, in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed.
has related synonym: serum TC level

blood differential white blood cell count
type: Class
subclass of: white blood cell count
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:24:28Z
def: The number of each type of leukocyte present in a specific volume of blood, usually 1 cubic millimeter.
has exact synonym: blood differential leukocyte count
has related synonym: blood differential WBC count

blood granulocyte count to total leukocyte count ratio
type: Class
subclass of: blood granulocyte count
subclass of: CMO_0002349
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:35:10Z
def: A calculated measurement in which the number of all granulocytes (regardless of type) in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage.
has related synonym: granulocyte count as percentage of total white blood cells
has related synonym: granulocyte count to total WBC count ratio
has related synonym: granulocyte count to total white blood cell count ratio
has related synonym: granulocyte percentage

blood eosinophil count to total leukocyte count ratio
type: Class
subclass of: blood granulocyte count
subclass of: blood granulocyte count to total leukocyte count ratio
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:38:12Z
def: A calculated measurement in which the number of eosinophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. An eosinophil is a granular leukocyte having a nucleus with two lobes connected by a thread of chromatin, and cytoplasm containing coarse, round granules of uniform size that stain readily with eosin and other acid dyes.
has related synonym: eosinophil count as percentage of total white blood cells
has related synonym: eosinophil count to total WBC count ratio
has related synonym: eosinophil granulocyte percentage
has related synonym: eosinophil percentage

blood neutrophil count to total leukocyte count ratio
type: Class
subclass of: blood granulocyte count
subclass of: blood granulocyte count to total leukocyte count ratio
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:39:37Z
def: A calculated measurement in which the number of neutrophil granulocytes is divided by the number of all white blood cells in a specified sample of peripheral venous blood, and the result presented as a ratio, fraction, quotient or percentage. A neutrophil is, or is in the process of becoming, a granular leucocyte having a nucleus with three to five lobes connected by threads of chromatin, cytoplasm containing very fine granules, and which is readily stainable with neutral dyes.
has exact synonym: neutrophil granulocyte percentage
has related synonym: neutrophil count as percentage of total white blood cells
has related synonym: neutrophil count to total WBC count ratio
has related synonym: neutrophil percentage
has related synonym: polymorphonuclear cell percentage

blood lymphocyte count to total leukocyte count ratio
type: Class
subclass of: CMO_0001495
subclass of: CMO_0002349
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T10:45:39Z
def: A calculated measurement in which the number of lymphocytes in a specified sample of blood is divided by the total number of white blood cells in the sample, and the result presented as a ratio, fraction, quotient or percentage.
has related synonym: lymphocyte count as percentage of total white blood cells
has related synonym: lymphocyte count to total WBC count ratio
has related synonym: lymphocyte percentage

total serum bilirubin level
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2010-12-13T11:30:05Z
def: The complete or entire amount of bilirubin in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Bilirubin is the bile pigment produced by breakdown of heme and reduction of biliverdin.

serum bicarbonate level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T12:01:33Z
def: The amount of carbonic acid dissolved in carbon dioxide and carbonate ion found in a specified volume of serum.

serum chloride level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T12:06:48Z
def: The amount of chloride ions found in a specified volume of serum.

blood glomerular filtration rate
type: Class
subclass of: blood chemistry measurement
subclass of: kidney measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:41:58Z
def: An estimation of the volume of blood filtered from the kidney glomerular capillaries into the Bowman's capsule per specified unit of time based on serum creatinine level, wieght and age of organism and other factors.

blood glomerular filtration rate, Diet in Renal Disease Formula (MDRD)
type: Class
subclass of: blood glomerular filtration rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:48:14Z

blood glomerular filtration rate, Chronic Kidney Disease Epidemiology Collaboration formula (CKE-EPI)
type: Class
subclass of: blood glomerular filtration rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:48:55Z
def: A calculated measurement which estimates the glomerular filtration rate (GFR), that is, the volume of fluid filtered from the renal capillaries per unit time, based on the serum creatinine level and adjusted for gender.

blood glomerular filtration rate, May Quadratic formula
type: Class
subclass of: blood glomerular filtration rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:50:15Z

blood glomerular filtration rate, Schwartz formula
type: Class
subclass of: blood glomerular filtration rate
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:50:43Z

serum potassium level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:52:02Z
def: Amount of potassium ions in a specified volume of serum.

serum sodium level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T02:56:30Z
def: The amount of sodium ions in a specified volume of serum.

serum calcium level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-04T03:15:06Z
def: The amount of calcium ions in a specified volume of serum.

pulmonary arterial diastolic blood pressure
type: Class
subclass of: diastolic blood pressure
subclass of: pulmonary arterial blood pressure measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-21T08:57:36Z
def: Blood pressure measured in the pulmonary artery during diastole, that is, during dilation or relaxation of the heart ventricles.

pulmonary arterial systolic blood pressure
type: Class
subclass of: systolic blood pressure
subclass of: pulmonary arterial blood pressure measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-21T08:58:00Z
def: Blood pressure measured in the pulmonary artery during systole, that is, during contraction of the heart ventricles.

heart left ventricle weight to body weight ratio
type: Class
subclass of: calculated heart left ventricle weight
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-01-21T09:42:17Z
def: A calculated value in which the weight of the left ventricle, the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body, is divided by the total weight of the body and the result presented as a ratio, fraction, quotient or percentage, thus normalizing it to body weight and by extension to the size of the organism.
has alternative id: CMO_0000540
has exact synonym: heart left ventricle weight as a percentage of body weight
has related synonym: LV mass/BW

absolute change in mean arterial blood pressure
type: Class
subclass of: mean arterial blood pressure
subclass of: change in calculated blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-10-28T04:24:16Z
def: The difference in mean arterial blood pressure between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

absolute change in heart rate
type: Class
subclass of: CMO_0002161
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-10-28T04:25:37Z
def: Absolute difference in heart rate between two points in time or two conditions.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

glomerulus count
type: Class
subclass of: kidney morphological measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-10-28T04:29:17Z
def: The number of glomeruli in all or part of a kidney. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation.
has exact synonym: glomeruli count

heart left ventricle dry weight
type: Class
subclass of: heart left ventricle weight
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-10-28T04:33:14Z

serum phosphate level
type: Class
subclass of: blood electrolyte measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T02:44:01Z
def: The amount of phosphorus, measured as inorganic phosphate, in a specified sample of serum.
has related synonym: serum inorganic phosphate level
has related synonym: serum inorganic phosphorus level
has related synonym: serum phosphorus level

serum glucose level
type: Class
subclass of: blood chemistry measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T02:45:05Z
def: Measurement of the amount of glucose, the monosaccharide sugar, C6H12O6, occurring widely in plant and animal tissues which is one of the three dietary monosaccharides that are absorbed directly into the bloodstream during digestion, is the end product of carbohydrate metabolism, and is the chief source of energy for living organisms, in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed.

serum albumin level
type: Class
subclass of: blood protein measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T02:48:13Z
def: The amount of albumin in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed.

serum alanine aminotransferase activity level
type: Class
subclass of: blood enzyme activity level
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T04:10:11Z
def: The amount of ezymatic activity of glutamic-pyruvate transaminase enzyme, commonly known as alanine transaminase or alanine aminotransferase (ALT), enzyme in a specified sample of serum. ALT catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Serum ALT level is used as an enzymatic marker for liver disease or damage.
has exact synonym: serum alanine transaminase activity level
has exact synonym: serum glutamic-pyruvate transaminase activity level
has related synonym: serum ALT activity level
has related synonym: serum GPT activity level

serum alkaline phosphatase activity level
type: Class
subclass of: blood enzyme activity level
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T04:11:05Z
def: Quantitation of the catalytic effect exerted by alkaline phosphatase (AP) in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. AP is an enzyme that catalyzes the cleavage of orthophosphate from orthophosphoric monoesters under alkaline conditions.

serum aspartate aminotransferase activity level
type: Class
subclass of: blood enzyme activity level
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-02T04:18:08Z
def: The amount of enzymatic activity of glutamic-oxaloacetic transaminase enzyme, commonly known as aspartate transaminase or aspartate aminotransferase (AST), in a specified sample of serum. AST catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid. Serum AST level is used as an enzymatic marker for liver disease or damage.
has exact synonym: serum aspartate transaminase activity level
has exact synonym: serum glutamic-oxaloacetic transaminase activity level
has related synonym: SGOT activity level
has related synonym: serum AST activity level
has related synonym: serum GOT activity level

urine protein level
type: Class
subclass of: urine measurement
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T01:45:21Z

left ventricular end-systolic blood pressure
type: Class
subclass of: left ventricular systolic blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:34:53Z
def: Measurement of the pressure within the heart left ventricle at the end of systole, the period of contraction of the heart when the blood is forced from the ventricles into the pulmonary artery (right ventricle) and the aorta (left ventricle).

left ventricular end-diastolic blood pressure
type: Class
subclass of: left ventricular diastolic blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:35:59Z
def: The pressure in the heart left ventricle at the end of diastole, the period when the heart is in a state of relaxation and expansion and the ventricles fill with blood.

absolute change in systolic blood pressure
type: Class
subclass of: change in systolic blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:36:40Z
def: Calculated measurement of a difference in the maximum arterial blood pressure, that is the pressure at the point of maximal contraction of the heart, between two points in time or two conditions expressed as a number (positive or negative), not as a ratio or percentage relative to another quantity.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

absolute change in diastolic blood pressure
type: Class
subclass of: change in diastolic blood pressure
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:36:56Z
def: Calculated measurement of a difference in diastolic blood pressure between two points or two conditions expressed as a number (positive or negative), not as a ratio or percentage relative to another quantity. The diastolic pressure is the minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

single kidney wet weight to body weight ratio
type: Class
subclass of: single kidney wet weight
subclass of: CMO_0001951
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:50:38Z
def: A calculated measurement in which the weight after removal from the body but without desiccation of a single kidney, one of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is divided by the total weight of the body and presented as a ratio, fraction or quotient, thus normalizing it to body weight.
has exact synonym: individual kidney wet weight to body weight ratio

single kidney wet weight as percentage of body weight
type: Class
subclass of: single kidney wet weight
subclass of: CMO_0001951
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-03T02:50:52Z
def: A calculated measurement in which the weight after removal from the body but without desiccation of a single kidney, one of the paired organs which function to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, is divided by the total weight of the body and presented as a percentage, thus normalizing it to body weight.
has exact synonym: individual kidney wet weight as percentage of body weight

heart right ventricle dry weight
type: Class
subclass of: heart right ventricle weight
imported from: cmo.owl
created by: mshimoyama
creation date: 2011-11-04T12:57:25Z

heart contraction measurement
type: Class
subclass of: heart measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T11:39:00Z
def: Any measurement of components of the periodic tightening and loosening of the heart muscle.
has related synonym: heart contractility measurement

time to onset of heart contraction
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T11:42:05Z
def: Measure of the time from the relaxation of the heart muscle to the beginning of the tightening of the heart muscle during contraction.

time to peak heart contraction
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T11:48:18Z
def: Measurement of the time from the beginning of heart muscle contraction to the maximum contracted state.

heart contraction pressure
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T11:56:51Z
def: Pressure exerted by the heart muscle in its maximally contracted state.

organ measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:00:53Z
def: Any measurement of a structural part of a system of the body that is composed of tissues and cells that enable it to perform a particular function.

heart measurement
type: Class
subclass of: cardiovascular measurement
subclass of: organ measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:06:19Z
comment: This is not the same term as the original "heart measurement". That term is now "heart morphological measurement".

heart effluent measurement
type: Class
subclass of: organ measurement
subclass of: heart measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:11:39Z
def: A measurement made on a fluid flowing out of the heart.

heart effluent volume
type: Class
subclass of: heart effluent measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:14:44Z
def: The volume of a fluid flowing out of the heart.

timed heart effluent volume
type: Class
subclass of: heart effluent volume
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:16:22Z
def: The volume of a fluid flowing out of the heart during a specified amount of time.

heart effluent enzyme level
type: Class
subclass of: heart effluent measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:21:20Z
def: The amount of an enzyme in a specified volume of fluid flowing out of the heart.

heart effluent lactate dehydrogenase activity level
type: Class
subclass of: heart effluent enzyme level
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:25:02Z
def: The amount of lactate dehydrogenase activity measured in a specified volume of fluid flowing out of the heart.
has exact synonym: heart effluent LDH activity level

organ lesion measurement
type: Class
subclass of: organ measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:45:18Z
def: Measurement of a lesion in an organ. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined.
has related synonym: tissue damage measurement

heart lesion measurement
type: Class
subclass of: heart measurement
subclass of: organ lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:48:03Z
def: A measurement of any lesion of the heart. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined.

infarction measurement
type: Class
subclass of: organ non-tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:50:09Z
def: Measurement of an area of necrotic tissue resulting from a reduction or obstruction of the oxygen supplied to that tissue.

heart infarction measurement
type: Class
subclass of: infarction measurement
subclass of: heart non-tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T05:58:36Z
def: Measurement of an area of necrotic tissue in the heart resulting from a reduction or obstruction of the oxygen supply.
has related synonym: myocardial infarction measurement

heart left ventricle infarction measurement
type: Class
subclass of: heart infarction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:09:00Z
def: Measurement of an area of necrotic tissue in the left ventricle of the heart resulting from a reduction or obstruction of the oxygen supply to the heart.

infarction size
type: Class
subclass of: infarction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:11:07Z
def: Measurement of the area, volume or weight of necrotic tissue resulting from a reduction or obstruction of the oxygen supplied to that tissue.

heart infarction size
type: Class
subclass of: heart infarction measurement
subclass of: infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:14:35Z
def: Measurement of the area, volume or weight of necrotic tissue in the heart resulting from a reduction or obstruction of the oxygen supply to the heart.

heart left ventricle infarction size
type: Class
subclass of: heart left ventricle infarction measurement
subclass of: heart infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:18:51Z
def: Measurement of the area, volume or weight of necrotic tissue in the heart left ventricle resulting from a reduction or obstruction of the oxygen supply to the heart.

calculated heart left ventricle infarction size
type: Class
subclass of: heart left ventricle infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:27:35Z

heart left ventricle infarction size as percentage of total heart left ventricle size
type: Class
subclass of: calculated heart left ventricle infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:28:08Z

heart ventricle weight
type: Class
subclass of: heart weight
subclass of: heart ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-15T06:46:40Z
def: The heaviness of one or both ventricles of the heart, that is, the lower chambers of the heart that pump blood away from the heart either to the lungs to be oxygenated or, once oxygenated, to the rest of the body, or the degree to which one or both ventricles of the heart are drawn toward the earth by gravity.

heart infarction weight
type: Class
subclass of: heart weight
subclass of: infarction size
subclass of: heart infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T02:50:48Z

heart infarction area
type: Class
subclass of: infarction size
subclass of: heart infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:02:09Z

heart left ventricle infarction weight
type: Class
subclass of: heart left ventricle infarction size
subclass of: heart infarction weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:02:46Z

heart left ventricle infarction area
type: Class
subclass of: heart left ventricle infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:03:35Z

calculated heart left ventricle infarction area
type: Class
subclass of: heart left ventricle infarction area
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:04:15Z

calculated heart left ventricle infarction weight
type: Class
subclass of: calculated heart left ventricle infarction size
subclass of: heart left ventricle infarction weight
subclass of: calculated heart infarction weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:04:51Z

heart left ventricle infarction weight as percentage of total heart left ventricle weight
type: Class
subclass of: heart left ventricle infarction size as percentage of total heart left ventricle size
subclass of: calculated heart left ventricle infarction weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:05:44Z

calculated heart infarction weight
type: Class
subclass of: heart infarction weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-02-21T03:08:57Z

absolute change in body temperature
type: Class
subclass of: body temperature
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-09T04:05:52Z
def: The difference in body temperature between two different points in time or between two different conditions.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

blood vessel resistance measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-09T05:24:30Z
def: Measurement of the amount of resistance in a blood vessel to the flow of blood or other fluid through it.

pulmonary vascular resistance (PVR)
type: Class
subclass of: blood vessel resistance measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-09T05:53:03Z
def: Resistance to blood flow by blood vessels in the lung.

calculated pulmonary vascular resistance
type: Class
subclass of: pulmonary vascular resistance (PVR)
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-09T05:57:02Z
def: Measurement of vascular resistance in lung blood vessels calculated from other indirect measurements.
has exact synonym: calculated PVR

calculated pulmonary vascular resistance normalized to body weight
type: Class
subclass of: calculated pulmonary vascular resistance
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-09T06:00:03Z
has narrow synonym: R_Flow100

blood vessel endothelium measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T12:26:02Z
def: Measurement made on the endothelial tissue or endothelial cells lining a blood vessel.

calculated blood vessel endothelium measurement
type: Class
subclass of: blood vessel endothelium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T12:29:04Z

FAPGG metabolism-surface area product
type: Class
subclass of: calculated blood vessel endothelium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T12:31:07Z

methylene blue metabolism-surface area product without auto-oxidation
type: Class
subclass of: calculated blood vessel endothelium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T01:02:07Z

methylene blue metabolism-surface area product after auto-oxidation
type: Class
subclass of: calculated blood vessel endothelium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T01:03:47Z

methylene blue to FAPGG metabolism-surface area product ratio
type: Class
subclass of: calculated blood vessel endothelium measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T01:12:29Z
def: Ratio of the methylene blue metabolism-surface area product without auto-oxidation to the FAPGG metabolism-surface area product.

blood vessel contractile force measurement
type: Class
subclass of: blood vessel constriction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T04:15:39Z
def: Any measurement of the energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from contraction of the muscular wall of the vessel.
has related synonym: blood vessel contractility measurement

blood vessel maximum contractile force
type: Class
subclass of: blood vessel contractile force measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T04:46:14Z
def: Measurement of the highest achievable amount of energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from contraction of the muscular wall of the vessel.
has related synonym: blood vessel maximum contractility measurement

maximum contractile force per wet weight of vessel
type: Class
subclass of: blood vessel maximum contractile force
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-13T04:47:52Z

chemical response/sensitivity measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:09:34Z
def: Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to a drug or other chemical stimulus.

calculated blood vessel contractile force measurement
type: Class
subclass of: blood vessel contractile force measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:16:11Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the energy produced by the active reduction in the diameter of a blood vessel, any one of the network of muscular tubes that carry blood through the body, resulting from contraction of the muscular wall of the vessel.

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
type: Class
subclass of: phenylephrine response/sensitivity measurement
subclass of: CMO_0002464
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:17:28Z
def: A calculated value for the concentration of phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of PE is halfway between the baseline value and the highest achievable value of such PE-induced contractile energy.
has exact synonym: phenylephrine half maximal effective concentration (EC50)
xref: CHEBI 8093

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
type: Class
subclass of: phenylephrine response/sensitivity measurement
subclass of: CMO_0002465
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:17:54Z
def: A calculated value for logarithm of the concentration of phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor, at which the energy produced by the active reduction in the diameter of a blood vessel in response to the application of PE is halfway between the baseline value and the highest achievable value of such PE-induced contractile energy. The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value.
has exact synonym: phenylephrine Log half maximal effective concentration (Log EC50)
xref: CHEBI 8093

calculated blood vessel dilation force reduction measurement
type: Class
subclass of: blood vessel dilation force reduction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:21:12Z
def: Measurement of the reduction in force during dilation of a blood vessel via calculations from direct measurements rather than expressing the direct measurements themselves.

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
type: Class
subclass of: calculated blood vessel dilation force reduction measurement
subclass of: acetylcholine response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:23:57Z
def: A calculated value for the concentration of acetylcholine (ACh), the ester of acetic acid and choline with chemical formula CH3C=OO(CH2)2-N(+)-(CH3)3 and IUPAC name 2-acetoxy-N,N,N-trimethylethanaminium, which acts as a neurotransmitter, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of ACh is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during ACh-induced relaxation of the vessel wall (i.e. the maximum effect of Ach which is the minimum contractile energy).
has exact synonym: acetylcholine half maximal effective concentration (EC50)
xref: CHEBI_15355

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
type: Class
subclass of: calculated blood vessel dilation force reduction measurement
subclass of: acetylcholine response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:24:16Z
def: A calculated value for logarithm of the concentration of acetylcholine (ACh), the ester of acetic acid and choline with chemical formula CH3C=OO(CH2)2-N(+)-(CH3)3 and IUPAC name 2-acetoxy-N,N,N-trimethylethanaminium, which acts as a neurotransmitter, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of ACh is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during ACh-induced relaxation of the vessel wall (i.e. the maximum effect of Ach which is the minimum contractile energy). The logarithm of the concentration is the exponent indicating the power to which 10 must be raised to obtain that concentration value.
has exact synonym: acetylcholine Log half maximal effective concentration (Log EC50)
xref: CHEBI_15355

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
type: Class
subclass of: calculated blood vessel dilation force reduction measurement
subclass of: sodium nitroprusside response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:24:44Z
def: A calculated value for the concentration of sodium nitroprusside (SNP), the red-colored inorganic salt with the formula Na2[Fe(CN)5NO]-2H2O used as a potent vasodilator, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of SNP is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during SNP-induced relaxation of the vessel wall (i.e. the maximum effect of SNP which is the minimum contractile energy).
has exact synonym: sodium nitroprusside half maximal effective concentration (EC50)
xref: CHEBI_29321
xref: CHEBI 9179

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
type: Class
subclass of: calculated blood vessel dilation force reduction measurement
subclass of: sodium nitroprusside response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-14T04:25:16Z
def: A calculated value for logarithm of the concentration of sodium nitroprusside (SNP), the red-coloured inorganic salt with the formula Na2[Fe(CN)5NO]-2H2O used as a potent vasodilator, at which the energy exerted during the active expansion in the diameter of a blood vessel in response to the application of SNP is halfway between the highest value, that is the force at greatest constriction (often measured in a pre-constricted blood vessel), and the lowest achievable value of such contractile energy during SNP-induced relaxation of the vessel wall (i.e. the maximum effect of SNP which is the minimum contractile energy).
has exact synonym: sodium nitroprusside Log half maximal effective concentration (Log EC50)
xref: CHEBI_29321
xref: CHEBI 9179

maximum contractile force per wet weight of aorta
type: Class
subclass of: maximum contractile force per wet weight of vessel
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T11:42:31Z

blood vessel dilation force reduction measurement
type: Class
subclass of: blood vessel dilation measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T11:48:29Z
def: Measurement of the reduction in force during blood vessel dilation.

blood vessel dilation expressed as percent of force at maximum constriction
type: Class
subclass of: calculated blood vessel dilation force reduction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T11:53:37Z

acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction
type: Class
subclass of: blood vessel dilation expressed as percent of force at maximum constriction
subclass of: acetylcholine response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T11:55:20Z
has related synonym: acetylcholine-induced blood vessel dilation expressed as percent of phenylephrine-induced vasoconstriction

sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction
type: Class
subclass of: blood vessel dilation expressed as percent of force at maximum constriction
subclass of: sodium nitroprusside response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T11:59:59Z
has related synonym: sodium nitroprusside-induced blood vessel dilation expressed as percent of phenylephrine-induced vasoconstriction

hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction
type: Class
subclass of: blood vessel dilation expressed as percent of force at maximum constriction
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:00:51Z

slope measurement of chemical-induced contraction
type: Class
subclass of: calculated blood vessel contractile force measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:03:40Z
has narrow synonym: slope measurement of phenylephrine-induced contraction
has related synonym: slope measurement of drug-induced contraction

fast-slope measurement of chemical-induced contraction
type: Class
subclass of: slope measurement of chemical-induced contraction
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:05:49Z
has narrow synonym: fast-slope measurement of phenylephrine-induced contraction
has related synonym: fast-slope measurement of drug-induced contraction

slow-slope measurement of chemical-induced contraction
type: Class
subclass of: slope measurement of chemical-induced contraction
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:06:21Z
has narrow synonym: slow-slope measurement of phenylephrine-induced contraction
has related synonym: slow-slope measurement of drug-induced contraction

acetylcholine response/sensitivity measurement
type: Class
subclass of: chemical response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:11:24Z
def: Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to acetylcholine (ACh), the ester of acetic acid and choline with chemical formula CH3C=OO(CH2)2-N(+)-(CH3)3 and IUPAC name 2-acetoxy-N,N,N-trimethylethanaminium, which acts as a neurotransmitter.
xref: CHEBI_15355

phenylephrine response/sensitivity measurement
type: Class
subclass of: chemical response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:12:47Z
def: Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to phenylephrine (PE), the phenylethanolamine with IUPAC name (R)-3-[-1-hydroxy-2-(methylamino)ethyl]phenol and formula C9H13NO2 that acts as a selective alpha1-adrenergic receptor agonist, decongestant and vasoconstrictor.
xref: CHEBI 8093

sodium nitroprusside response/sensitivity measurement
type: Class
subclass of: chemical response/sensitivity measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-15T12:13:21Z
def: Measurement of an organism's, organ's, tissue's or cell's capacity to respond, such as by a change in activity, state or condition, to sodium nitroprusside (SNP), the red-colored inorganic salt with the formula Na2[Fe(CN)5NO]-2H2O used as a potent vasodilator.
xref: CHEBI_29321

percent change in heart rate
type: Class
subclass of: CMO_0002161
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:21:00Z

change in calculated blood pressure
type: Class
subclass of: calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:31:30Z
def: Calculation of a difference between representations of blood pressure in a treated versus untreated state or over time, after the original values have been normalized or adjusted by a mathematical process or computation. Blood pressure is the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood.

change in developed blood pressure
type: Class
subclass of: developed blood pressure
subclass of: change in calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:31:52Z
def: A calculated measurement of the difference in developed blood pressure between a treated state and a control state. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

percent change in developed blood pressure
type: Class
subclass of: change in developed blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:32:19Z
def: A calculated measurement of the difference in developed blood pressure between a treated state and a control state, expressed as a percentage. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

change in systolic blood pressure
type: Class
subclass of: systolic blood pressure
subclass of: calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:34:31Z
def: Calculated measurement of a difference in the maximum arterial blood pressure, that is the pressure at the point of maximal contraction of the heart, between two points in time or two conditions.

percent change in systolic blood pressure
type: Class
subclass of: change in systolic blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:35:00Z
def: The relative difference in the maximum arterial blood pressure, that is the pressure at the point of maximal contraction of the heart, between two points in time or two conditions expressed as a percentage.

change in arterial blood flow rate
type: Class
subclass of: arterial blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:37:30Z

percent change in arterial blood flow rate
type: Class
subclass of: change in arterial blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:38:02Z

absolute change in arterial blood flow rate
type: Class
subclass of: change in arterial blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-20T04:38:35Z
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

percent change in left ventricular developed pressure
type: Class
subclass of: percent change in developed blood pressure
subclass of: change in left ventricular developed pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-21T01:08:08Z
def: A calculated measurement of the difference in developed pressure measured in the heart left ventricle between a treated state and a control state, expressed as a percentage. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

change in left ventricular developed pressure
type: Class
subclass of: left ventricular developed pressure
subclass of: change in developed blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-21T01:09:30Z
def: A calculated measurement of the difference in developed pressure measured in the heart left ventricle between a treated state and a control state. Developed pressure is systolic minus diastolic pressure when measured in an isolated organ or vessel under conditions where perfusion pressure or flow can be controlled.

change in left ventricular systolic blood pressure
type: Class
subclass of: left ventricular systolic blood pressure
subclass of: change in systolic blood pressure
subclass of: CMO_0001744
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-21T01:13:41Z
def: Difference in the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta, between two points in time or two conditions.

percent change in left ventricular systolic blood pressure
type: Class
subclass of: percent change in systolic blood pressure
subclass of: change in left ventricular systolic blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-21T01:14:31Z
def: The relative difference in the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta, between two points in time or two conditions expressed as a percentage.

heart effluent lactate dehydrogenase activity level normalized to heart weight
type: Class
subclass of: heart effluent lactate dehydrogenase activity level
imported from: cmo.owl
created by: JSmith
creation date: 2012-03-30T07:52:39Z
def: The activity level of LDH in effluent expressed relative to the weight of the heart; calculated as LDH activity divided by heart wet weight.

heart left ventricle weight
type: Class
subclass of: heart ventricle weight
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-07T11:37:18Z

heart right ventricle weight
type: Class
subclass of: heart ventricle weight
subclass of: heart right ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-07T11:38:49Z

mean pulmonary arterial blood pressure
type: Class
subclass of: mean arterial blood pressure
subclass of: pulmonary arterial blood pressure measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-07T12:01:20Z
def: The average blood pressure within the pulmonary artery over a specified period of time, or technically over a complete cycle of one heartbeat.
has related synonym: mean pulmonary artery (PA) pressure

pulmonary arterial blood pressure measurement
type: Class
subclass of: blood pressure measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-07T02:24:23Z
def: Measurement of blood pressure in the pulmonary artery.
has related synonym: pulmonary artery (PA) blood pressure measurement
has related synonym: pulmonary artery pressure

organ tumorous lesion measurement
type: Class
subclass of: organ lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-26T11:34:46Z
def: Measurement of an organ lesion which is or has the potential to become a tumor, that is, a neoplasm or new growth of tissue in which cell multiplication is more or less uncontrolled and progressive. Tumorous lesions include tumors, preneoplastic lesions, and hyperplastic lesions composed of histologically normal cells.

organ non-tumorous lesion measurement
type: Class
subclass of: organ lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-26T11:46:40Z
def: Measurement of an organ lesion which is not neoplastic in origin. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. Examples of non-tumorous lesions would include wounds, sores, ulcers, infarctions, etc.

heart non-tumorous lesion measurement
type: Class
subclass of: heart lesion measurement
subclass of: organ non-tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-26T12:53:39Z
def: Measurement of a heart lesion which is not neoplastic in origin. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. Examples of non-tumorous lesions would include wounds, sores, ulcers, infarctions, etc.

heart tumorous lesion measurement
type: Class
subclass of: heart lesion measurement
subclass of: organ tumorous lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-06-26T01:22:44Z
def: Measurement of a lesion of the heart which is or has the potential to become a tumor, that is, a neoplasm or new growth of tissue in which cell multiplication is more or less uncontrolled and progressive. Tumorous lesions include tumors, preneoplastic lesions, and hyperplastic lesions composed of histologically normal cells.

kidney measurement
type: Class
subclass of: renal/urinary measurement
subclass of: organ measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T10:34:14Z
def: Any measurement, morphological or physiological, involving the kidney or any part thereof.
has related synonym: Not4Curation

renal blood flow rate
type: Class
subclass of: blood flow rate
subclass of: kidney measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T10:38:08Z
def: Renal blood flow (RBF) is the volume of blood delivered to or exiting from the kidneys per unit time.

renal arterial blood flow rate
type: Class
subclass of: arterial blood flow rate
subclass of: renal blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T10:44:48Z
def: Arterial renal blood flow (RBFa) is the volume of blood delivered to the kidneys per unit time via the renal arteries.

renal venous blood flow rate
type: Class
subclass of: venous blood flow rate
subclass of: renal blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T10:48:22Z
def: Venous renal blood flow (RBFv) is the volume of blood exiting from the kidneys per unit time via the renal veins.

heart right ventricle weight to body weight ratio
type: Class
subclass of: calculated heart right ventricle weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T12:08:49Z
def: A calculated value in which the weight of the right ventricle, the lower chamber of the right side of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, is divided by the total weight of the body and presented as a ratio thus normalizing it to body weight.

heart right ventricle weight as a percentage of body weight
type: Class
subclass of: calculated heart right ventricle weight
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-11T12:09:38Z
def: A calculated value in which the weight of the right ventricle, the lower chamber of the right side of the heart, which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung, is presented as percentage of the total weight of the body thus normalizing it to body weight.

heart left ventricle morphological measurement
type: Class
subclass of: heart ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-18T04:24:26Z
def: Any measurement of the physical form or structure of the left ventricle of the heart. The left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body.
comment: Note, "left" in this context refers to the perspective of the organism, not that of the nobserver.

heart right ventricle morphological measurement
type: Class
subclass of: heart ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-18T04:30:51Z
def: Any measurement of the physical form or structure of the right ventricle of the heart. The right ventricle is the lower chamber of the right side of the heart (from the perspective of the organism rather than the observer), which pumps venous blood through the pulmonary trunk and arteries to the capillaries of the lung.

blood vessel lesion measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T10:04:12Z
def: Measurement of a localized pathological change in structure of a blood vessel due to injury or disease; especially one that is circumscribed and well defined.

calculated blood vessel diameter measurement
type: Class
subclass of: blood vessel diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:15:46Z
def: A measurement of blood vessel diameter which has been normalized or adjusted by a mathematical process or computation.
has related synonym: Not4Curation

blood vessel wall thickness
type: Class
subclass of: CMO_0001997
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:18:48Z

calculated blood vessel wall thickness measurement
type: Class
subclass of: blood vessel wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:20:54Z
def: A measurement of the depth of the wall of a blood vessel which has been normalized or adjusted by a mathematical process or computation.
has related synonym: Not4Curation

artery wall thickness
type: Class
subclass of: blood vessel wall thickness
subclass of: CMO_0001410
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:23:13Z
def: A measurement of the depth of the wall of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues.

calculated artery wall thickness measurement
type: Class
subclass of: calculated blood vessel wall thickness measurement
subclass of: artery wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:27:42Z
def: A measurement of the depth of the wall of an artery which has been normalized or adjusted by a mathematical process or computation. An artery is one of the large blood vessels carrying blood in a direction away from the heart to the tissues.
has related synonym: Not4Curation

artery diameter
type: Class
subclass of: blood vessel diameter
subclass of: artery measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:32:00Z

blood vessel inner diameter
type: Class
subclass of: blood vessel diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:39:26Z
def: The length of a line which crosses a transverse view of a blood vessel, passing through its center and ending on either side at the inner surface of the blood vessel wall.
has exact synonym: blood vessel lumen diameter

blood vessel outer diameter
type: Class
subclass of: blood vessel diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:41:25Z
def: The length of a line which crosses a transverse view of a blood vessel, passing through its center and ending on either side at the outer surface of the blood vessel wall.

artery inner diameter
type: Class
subclass of: artery diameter
subclass of: blood vessel inner diameter
subclass of: CMO_0001408
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:43:00Z
def: The length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the inner surface of the blood vessel wall.
has exact synonym: artery lumen diameter

artery outer diameter
type: Class
subclass of: artery diameter
subclass of: blood vessel outer diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:44:18Z
def: The length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the outer surface of the blood vessel wall.

calculated artery diameter measurement
type: Class
subclass of: calculated blood vessel diameter measurement
subclass of: artery diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:48:55Z
def: Measurement of the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at either the inner surface or outer surface of the blood vessel wall, which has been normalized or adjusted by a mathematical process or computation.
has related synonym: Not4Curation

artery measurement
type: Class
subclass of: blood vessel measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:57:08Z
def: Any measurement of one of the large blood vessels carrying blood in a direction away from the heart to the tissues.

artery lesion measurement
type: Class
subclass of: blood vessel lesion measurement
subclass of: artery measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T12:59:52Z
def: Measurement of any localized pathological change in structure of an artery, one of the large blood vessels carrying blood in a direction away from the heart to the tissues, due to injury or disease; especially one that is circumscribed and well defined.

calculated artery lesion measurement
type: Class
subclass of: artery lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T02:04:57Z
def: Measurement which has been normalized or adjusted by a mathematical process or computation of any localized pathological change in structure of an artery due to injury or disease; especially one that is circumscribed and well defined.
has related synonym: Not4Curation

calculated blood vessel lesion measurement
type: Class
subclass of: blood vessel lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T02:13:01Z
def: Measurement which has been normalized or adjusted by a mathematical process or computation of any localized pathological change in structure of a blood vessel due to injury or disease; especially one that is circumscribed and well defined.
has related synonym: Not4Curation

blood vessel wall thickness to blood vessel inner diameter ratio
type: Class
subclass of: calculated blood vessel diameter measurement
subclass of: calculated blood vessel wall thickness measurement
subclass of: calculated blood vessel lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T02:14:51Z
def: A calculated measurement in which the ratio of the wall thickness (WT) of a blood vessel is divided by the inner diameter (ID) of that vessel at that location, and the result presented as a ratio, fraction, quotient or percentage, for example, WT/ID x 100. This measurement is often used to assess stenosis, a pathological narrowing of a blood vessel.
has exact synonym: blood vessel wall thickness as percentage of blood vessel lumen diameter
has related synonym: blood vessel stenosis measurement
has related synonym: blood vessel wall thickness as percentage of blood vessel inner diameter

artery wall thickness to artery inner diameter ratio
type: Class
subclass of: calculated artery wall thickness measurement
subclass of: calculated artery lesion measurement
subclass of: blood vessel wall thickness to blood vessel inner diameter ratio
subclass of: calculated artery inner diameter measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T02:16:51Z
def: Ratio of the wall thickness (WT) of an artery to inner diameter (ID) of that artery at that location, usually expressed as a percentage, i.e. WT/ID x 100, but could also be expressed as a ratio, fraction or quotient. This measurement can be used to assess stenosis, a pathological narrowing of a blood vessel.
has related synonym: arterial stenosis measurement
has related synonym: artery wall thickness as percentage of artery inner diameter
has related synonym: artery wall thickness as percentage of artery lumen diameter

calculated artery inner diameter measurement
type: Class
subclass of: artery inner diameter
subclass of: calculated artery diameter measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T02:25:16Z
def: A measurement of the length of a line which crosses a transverse view of an artery, passing through its center and ending on either side at the inner surface of the blood vessel wall, after that measurement has been normalized or adjusted by a mathematical process or computation. An artery is a blood vessel that carries blood away from the heart.
has related synonym: Not4Curation

ventricle contraction measurement
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-26T03:24:53Z
def: Any measurement of components of the periodic tightening and loosening of the muscles of a ventricle of the heart.

heart left ventricular end-diastolic diameter
type: Class
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T03:14:05Z
def: The diameter across the left ventricle of the heart at the end of diastole, that is, when the heart muscle is maximally relaxed, and usually corresponds to its largest diameter.
has related synonym: LVDD
has related synonym: LVEDD
has related synonym: left ventricular end-diastolic dimension

heart left ventricle end-systolic diameter
type: Class
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T03:32:16Z
def: The diameter across the left ventricle of the heart at the end of systole, that is, when the heart muscle is maximally contracted, and usually corresponds to its smallest diameter.
has related synonym: LVESD
has related synonym: LVSD
has related synonym: left ventricular end-systolic dimension

calculated heart left ventricle morphological measurement
type: Class
subclass of: heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T03:42:40Z
def: A measurement of the physical form or structure of the left ventricle of the heart which has been normalized or adjusted by a mathematical process or computation. The heart left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body.

heart left ventricle fractional shortening
type: Class
subclass of: calculated heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T03:51:33Z
def: A calculated measurement corresponding to the ratio or percent reduction in left ventricular diameter between end-diastole and end-systole. Can be calculated as the left ventricle end-diastolic diameter (LVDd) minus the left ventricle end-systolic diameter (LVSd) divided by the left ventricle end-diastolic diameter (LVDd) with the quotient multiplied by 100, i.e. FS = [(LVDd-LVSd)/LVDd] x 100.

heart left ventricle anterior wall thickness
type: Class
subclass of: heart left ventricle morphological measurement
subclass of: heart anterior wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T04:11:09Z
def: The thickness or depth of the ventral/anterior wall of the left ventricle of the heart. The ventral/anterior wall is the portion of the muscle enclosing the ventricle which is farthest from the spine and closest to the chest wall of the organism.
has related synonym: heart left ventricle ventral wall thickness

heart ventricle septal wall thickness
type: Class
subclass of: heart right ventricle posterior wall thickness
subclass of: heart left ventricle anterior wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T05:59:34Z
def: The thickness or depth of the septal wall of the heart ventricles. The septal wall is the portion of the heart left ventricle ventral/anterior wall and right ventricle dorsal/posterior wall which is shared between the ventricles.
has exact synonym: heart ventricle septal wall thickness
has related synonym: SWT
has related synonym: antero-septal wall thickness
has related synonym: heart interventricular septum thickness
has related synonym: heart intraventricular wall thickness
has related synonym: heart ventricle septum thickness

heart left ventricle relative wall thickness
type: Class
subclass of: calculated heart left ventricle morphological measurement
subclass of: heart ventricle relative wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T06:00:34Z
def: A calculated measurement of left ventricular geometry and is calculated by dividing the end-diastolic diameter into 2x the posterior wall thickness, 2x the septal wall thickness or the sum of the posterior and septal wall thicknesses. It represents a measure of the wall thickness normalized to the size of the ventricle lumen.

heart left ventricle end-diastolic relative wall thickness
type: Class
subclass of: heart left ventricle relative wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-27T06:15:29Z
def: A calculated measurement of left ventricular geometry and is calculated by dividing the end-diastolic diameter into 2x the posterior wall thickness at end-diastole, 2x the septal wall thickness at end-diastole or the sum of the posterior and septal wall thicknesses at end-diastole. It represents a measure of the wall thickness normalized to the size of the ventricle lumen.

heart anterior wall thickness
type: Class
subclass of: heart wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T10:15:23Z
def: The thickness or depth of the ventral/anterior wall of the heart. The ventral wall is the portion of the heart muscle which is farthest from the spine and closest to the chest wall of the organism.
has related synonym: heart ventral wall thickness

calculated heart wall thickness measurement
type: Class
subclass of: heart wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T10:31:58Z
has related synonym: Not4Curation

heart relative wall thickness
type: Class
subclass of: calculated heart wall thickness measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T11:04:28Z

heart ventricle relative wall thickness
type: Class
subclass of: heart relative wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T11:05:55Z

mean velocity of circumferential fiber shortening
type: Class
subclass of: heart contraction measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T01:25:59Z
def: The extent of shortening of the minor internal circumference (at the midpoint of the long axis) between end-diastole and end-systole, divided by the time required for shortening.
has exact synonym: mean circumferential fiber shortening rate
has related synonym: mean VCF

heart right ventricle anterior wall thickness
type: Class
subclass of: heart anterior wall thickness
imported from: cmo.owl
created by: JSmith
creation date: 2012-07-30T02:57:57Z
def: The thickness or depth of the ventral/anterior wall of the right ventricle of the heart. The ventral wall is the portion of the muscle enclosing the ventricle which is farthest from the spine and closest to the chest wall of the organism.
has related synonym: heart right ventricle ventral wall thickness

superficial glomerulus count
type: Class
subclass of: glomerulus count
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-02T01:00:46Z
def: Count of the number of glomeruli located in the superficial layer of the renal cortex, the cortex corticis. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation.
has exact synonym: superficial glomeruli count

count of superficial glomeruli directly contacting the kidney surface
type: Class
subclass of: superficial glomerulus count
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-02T01:14:28Z
def: Count of the number of glomeruli located in the superficial layer of the renal cortex, the cortex corticis, and directly in contact with the surface of the kidney, i.e. the renal capsule. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation.
has related synonym: surface glomeruli count

count of superficial glomeruli not directly contacting the kidney surface
type: Class
subclass of: superficial glomerulus count
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-02T01:15:32Z
def: Count of the number of glomeruli located in the superficial layer of the renal cortex, the cortex corticis but without any direct contact with the surface of the kidney, i.e. the renal capsule. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation.

heart infarction volume
type: Class
subclass of: infarction size
subclass of: heart infarction size
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-03T06:05:33Z

change in diastolic blood pressure
type: Class
subclass of: diastolic blood pressure
subclass of: calculated blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-03T06:17:05Z
def: Measurement of any change or difference in the diastolic blood pressure between two points or two conditions. The diastolic pressure is the minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood.
has related synonym: Not4Curation

percent change in diastolic blood pressure
type: Class
subclass of: change in diastolic blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-03T06:19:27Z
def: The relative difference in the diastolic blood pressure between two points or two conditions, expressed as a percentage. The diastolic pressure is the minimum arterial pressure within the cardiac cycle, usually at the point at which the heart is in a state of relaxation and expansion. This is the time when the ventricles fill with blood.

absolute change in left ventricular systolic blood pressure
type: Class
subclass of: change in left ventricular systolic blood pressure
imported from: cmo.owl
created by: JSmith
creation date: 2012-08-13T01:16:23Z
def: Calculated measurement of a difference in the pressure within the heart left ventricle at the point of maximal contraction, when the blood is forced from the left ventricle into the aorta, between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

head temperature
type: Class
subclass of: body temperature
imported from: cmo.owl
created by: jsmith
creation date: 2012-08-23T03:27:50Z
def: Temperature measured at the surface of or within the head of an experimental subject. Because the temperature of the head/brain can influence neurological measurements, head temperature is or can be considered to be distinct from core body temperature.
has related synonym: cranial temperature

core body temperature
type: Class
subclass of: body temperature
imported from: cmo.owl
created by: jsmith
creation date: 2012-08-23T04:06:16Z
def: The temperature of the internal tissues and organs of the body.
has related synonym: core temperature

calculated heart left ventricle weight
type: Class
subclass of: calculated heart weight
subclass of: heart left ventricle weight
subclass of: calculated heart left ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-09-13T06:09:33Z
def: A measurement which has been normalized or adjusted by a mathematical process or computation of the weight of the left ventricle of the heart, that is, its the heaviness or degree to which it is drawn toward the earth by gravity. The heart left ventricle is the lower chamber of the left side of the heart, which pumps oxygenated blood out through the aorta to all the tissues of the body.

calculated heart right ventricle weight
type: Class
subclass of: calculated heart weight
subclass of: heart right ventricle weight
subclass of: calculated heart right ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-09-13T06:11:08Z

calculated heart right ventricle morphological measurement
type: Class
subclass of: heart right ventricle morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-09-13T06:14:55Z

cerebral artery inner diameter
type: Class
subclass of: artery inner diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-03T05:31:53Z
def: The length of a line which crosses a transverse view of a cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The cerebral arteries are those which supply blood to the brain, more specifically, to the cerebrum.
has related synonym: cerebral artery lumen diameter

anterior cerebral artery inner diameter
type: Class
subclass of: cerebral artery inner diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-03T05:39:47Z
def: The length of a line which crosses a transverse view of an anterior cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The anterior cerebral artery (ACA) is one of a pair of arteries that supply oxygenated blood to the most medial portions of the frontal lobes and superior medial parietal lobes of the brain.
has related synonym: ACA inner diameter
has related synonym: anterior cerebral artery lumen diameter

middle cerebral artery inner diameter
type: Class
subclass of: cerebral artery inner diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-03T05:48:00Z
def: The length of a line which crosses a transverse view of a middle cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The middle cerebral arteries are the largest of the cerebral arteries and supply blood to the lateral cerebral cortex, anterior temporal lobes and insular cortices of the brain.
has related synonym: MCA inner diameter
has related synonym: middle cerebral artery lumen diameter

posterior cerebral artery inner diameter
type: Class
subclass of: cerebral artery inner diameter
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-03T05:59:18Z
def: The length of a line which crosses a transverse view of a posterior cerebral artery, passing through its center and ending on either side at the inner surface of the blood vessel wall. The posterior cerebral artery (PCA) is one of a pair of blood vessels that supply blood to the posterior aspect, i.e. the occipital lobe, of the brain.
has related synonym: PCA inner diameter
has related synonym: posterior cerebral artery lumen diameter

kidney lesion measurement
type: Class
subclass of: organ lesion measurement
subclass of: kidney measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T02:59:36Z
def: Measurement of a lesion in kidney, he organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined.

kidney non-tumorous lesion measurement
type: Class
subclass of: organ non-tumorous lesion measurement
subclass of: kidney lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T03:01:39Z
def: Measurement of a lesion in the kidney, he organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, which is not neoplastic in origin. A lesion is a localized pathological change in structure of an organ or tissue due to injury or disease; especially one that is circumscribed and well defined. Examples of non-tumorous lesions would include wounds, sores, ulcers, infarctions, etc.

kidney tumorous lesion measurement
type: Class
subclass of: organ tumorous lesion measurement
subclass of: kidney lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T03:03:01Z
def: Measurement of a lesion in the kidney, he organ which functions to maintain proper water and electrolyte balance, regulate acid-base concentration, and filter the blood of metabolic wastes, which is or has the potential to become a tumor, that is, a neoplasm or new growth of tissue in which cell multiplication is more or less uncontrolled and progressive. Tumorous lesions include tumors, preneoplastic lesions, and hyperplastic lesions composed of histologically normal cells.

kidney glomerulosclerotic lesion measurement
type: Class
subclass of: CMO_0001254
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T03:09:04Z
def: Any measurement of lesions resulting from fibrosis, scarring or hyaline deposits within a kidney glomerulus, a tuft of capillaries situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney, that filters waste products from the blood and thus initiates urine formation.
has related synonym: kidney glomerulosclerosis measurement
has related synonym: renal glomerulosclerosis measurement
has related synonym: renal glomerulosclerotic lesion measurement

calculated kidney glomerulosclerotic lesion measurement
type: Class
subclass of: kidney glomerulosclerotic lesion measurement
subclass of: CMO_0002378
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T03:43:25Z
def: A measurement of lesions resulting from fibrosis, scarring or hyaline deposits within one or more kidney glomeruli which has been normalized, adjusted or derived by a mathematical process or computation.
has related synonym: calculated kidney glomerulosclerosis measurement
has related synonym: calculated renal glomerulosclerosis measurement
has related synonym: calculated renal glomerulosclerotic lesion measurement

index of glomerular damage
type: Class
subclass of: calculated kidney glomerulosclerotic lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-08T03:45:56Z
def: A measurement of lesions resulting from fibrosis, scarring or hyaline deposits within kidney glomeruli which is derived from a combination of multiple measurements and/or objective or subjective severity scores according to a specified formula or set of criteria.
has related synonym: glomerular damage composite score
has related synonym: glomerulosclerosis composite score
has related synonym: glomerulosclerosis damage index

muscle measurement
type: Class
subclass of: clinical measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-12T05:28:37Z
def: Any measurement, morphological or physiological of a muscle or a group of muscles. Muscles are organs or tissues composed of bundles of fibers that have the power to contract and hence to produce movement.

kidney glomerulus morphological measurement
type: Class
subclass of: kidney morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-15T11:45:27Z
def: Measurement of the physical form or structure of one or more glomeruli in the kidney. Glomeruli are the tufts of capillaries each situated within a Bowman's capsule at the end of a renal tubule in the vertebrate kidney that filter waste products from the blood and thus initiate urine formation.

kidney glomerulus diameter
type: Class
subclass of: kidney glomerulus morphological measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-15T11:48:00Z
def: The length of a straight line passing through the center of a kidney glomerulus and connecting opposite points on its circumference.
has exact synonym: kidney glomerular diameter

calculated renal blood flow rate
type: Class
subclass of: renal blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-15T11:55:42Z
def: A measurement of the volume of blood delivered to or exiting from the kidneys per unit time, which has been normalized, adjusted or derived by a mathematical process or computation.

absolute change in renal blood flow rate
type: Class
subclass of: calculated renal blood flow rate
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-15T11:59:32Z
def: The difference in the volume of blood delivered to or exiting from the kidneys per unit time between two points in time or two conditions expressed as the result of the subtraction in and of itself without comparison by ratio with another quantity.
comment: The term "absolute change" refers to the subtraction of one value from another, as opposed to a dissimilarity of two values expressed as a ratio or as a percentage. In this context it is not intended to necessarily imply the difference expressed as an absolute value |n|, that is, the numeric value of the difference without regard to its sign.

kidney glomerulosclerotic lesion count
type: Class
subclass of: kidney glomerulosclerotic lesion measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T12:14:30Z
def: The number of kidney glomeruli with lesions resulting from fibrosis, scarring or hyaline deposits, or the number of such lesions in a specified sample.
has related synonym: damaged glomeruli count
has related synonym: number of sclerotic glomeruli
has related synonym: sclerotic glomeruli count
has related synonym: sclerotic glomerulus count

kidney protein/peptide composition measurement
type: Class
subclass of: CMO_0001852
subclass of: CMO_0002577
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T01:31:20Z
def: Any measurement involving the composition, that is, the absolute amount, relative amount or type of one or more proteins (complex high molecular weight organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages) or peptides (low molecular weight compounds composed of at least two amino acids joined by peptide linkages) in kidney.
has exact synonym: kidney tissue protein/peptide composition measurement

renal cortex measurement
type: Class
subclass of: kidney measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:13:42Z
def: Any measurement, morphological or physiological of the outer part of the kidney, composed mainly of glomeruli and convoluted tubules.
has exact synonym: kidney cortex measurement

renal medulla measurement
type: Class
subclass of: kidney measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:20:09Z
def: Any measurement, morphological or physiological, of the renal medulla, the innermost part of the kidney which contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood.
has exact synonym: kidney medulla measurement

renal medulla protein measurement
type: Class
subclass of: renal medulla measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:28:36Z
def: Any measurement involving the amount, composition or type of protein, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, in kidney medulla, the innermost part of the kidney which contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood.
has exact synonym: kidney medulla protein measurement

renal cortex protein measurement
type: Class
subclass of: renal cortex measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:31:18Z
def: Any measurement involving the amount, composition or type of protein, the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages, in renal cortex, the outer part of the kidney, composed mainly of glomeruli and convoluted tubules.
has exact synonym: kidney cortex protein measurement

calculated kidney protein composition measurement
type: Class
subclass of: kidney protein/peptide composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:34:08Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation, of the composition, that is, the absolute amount, relative amount or type, of protein (the complex organic compounds containing carbon, hydrogen, oxygen, nitrogen, and sulfur consisting of alpha-amino acids joined by peptide linkages) in kidney.
has related synonym: calculated renal protein composition measurement

calculated renal cortex protein composition measurement
type: Class
subclass of: renal cortex protein measurement
subclass of: calculated kidney protein composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:41:53Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation involving the amount, composition or type of protein in the kidney cortex, the outer part of the kidney, composed mainly of glomeruli and convoluted tubules.
has related synonym: calculated kidney cortex protein composition measurement

calculated renal medulla protein composition measurement
type: Class
subclass of: renal medulla protein measurement
subclass of: calculated kidney protein composition measurement
imported from: cmo.owl
created by: JSmith
creation date: 2012-10-22T03:43:38Z
def: A measurement which has been normalized, adjusted or derived by a mathematical process or computation involving the amount, composition or type of protein in the renal medulla, the innermost part of the kidney which contains the structures of the nephrons responsible for maintaining the salt and water balance of the blood.
has exact synonym: calculated kidney medulla protein composition measurement