Alzheimer disease dementia
label: Combination of amyloid pathology and dementia: Amyloid + dementia

binary scale

has property

An age since birth measurement datum at the time of a clinical visit Shape
type: NodeShape
type: numeric scale
target class: An age since birth at the time of a clinical visit.
closed: true
property:
  path: type
  has value: UO_0000033
  min count: 1
property:
  path: has value
  datatype: int
  name: An age since birth at the time of a clinical visit.
  min count: 1
  max count: 1
  min inclusive: 0.0
property:
  path: has value
  datatype: int
  name: An age since birth at the time of a clinical visit.
  min count: 1
  max count: 1
  max inclusive: 130.0

Demographics Shape
type: NodeShape
target class: quantitative concept
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: An age since birth measurement datum at the time of a clinical visit Shape
  min count: 1
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: Age when biosample was taken Shape
  min count: 1
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: Duration of formal education observable entity Shape
  min count: 1
target class: qualitative concept
property:
  path: type
  has value: qualitative concept
property:
  path: category
  node: Finding related to biological sex Shape
  min count: 1

Age when biosample was taken Shape
type: NodeShape
type: numeric scale
target class: Age when biosample was taken.
closed: true
property:
  path: type
  has value: UO_0000033
  min count: 1
property:
  path: has value
  datatype: int
  name: Age when biosample was taken.
  min count: 1
  max count: 1
  min inclusive: 0.0
property:
  path: has value
  datatype: int
  name: Age when biosample was taken.
  min count: 1
  max count: 1
  max inclusive: 130.0

Duration of formal education observable entity Shape
type: NodeShape
type: numeric scale
target class: Duration of formal education (observable entity)
closed: true
property:
  path: type
  has value: UO_0000189
  min count: 1
property:
  path: has value
  datatype: int
  name: Duration of formal education (observable entity)
  min count: 1
  max count: 1
  min inclusive: 0.0
property:
  path: has value
  datatype: int
  name: Duration of formal education (observable entity)
  min count: 1
  max count: 1
  max inclusive: 130.0

Montreal cognitive assessment score Shape
type: NodeShape
type: numeric scale
target class: Montreal cognitive assessment score
closed: true
property:
  path: type
  has value: UO_0000189
  min count: 1
property:
  path: has value
  datatype: int
  name: Montreal cognitive assessment score
  min count: 1
  max count: 1
  min inclusive: 0.0
property:
  path: has value
  datatype: int
  name: Montreal cognitive assessment score
  min count: 1
  max count: 1
  max inclusive: 31.0

Cognition Shape
type: NodeShape
target class: quantitative concept
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: Montreal cognitive assessment score Shape
  min count: 1
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: Mini Mental State Examination Shape
  min count: 1
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: Memory assessment Shape
  min count: 1
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: Raw score of memory assessment Shape
  min count: 1
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: Local norms of memory assessment Shape
  min count: 1
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: Zscore of memory assessment Shape
  min count: 1
target class: temporal concept
property:
  path: type
  has value: temporal concept
property:
  path: SIO_000011
  node: Date of procedure observable entity Shape
  min count: 1

Mini Mental State Examination Shape
type: NodeShape
type: numeric scale
target class: Mini Mental State Examination
closed: true
property:
  path: type
  has value: UO_0000189
  min count: 1
property:
  path: has value
  datatype: int
  name: Mini Mental State Examination
  min count: 1
  max count: 1
  min inclusive: 0.0
property:
  path: has value
  datatype: int
  name: Mini Mental State Examination
  min count: 1
  max count: 1
  max inclusive: 31.0

Memory assessment Shape
type: NodeShape
type: numeric scale
target class: Memory assessment
closed: true
property:
  path: type
  has value: UO_0000189
  min count: 1
property:
  path: has value
  datatype: int
  name: Memory assessment
  min count: 1
  max count: 1
  min inclusive: 0.0

Raw score of memory assessment Shape
type: NodeShape
type: numeric scale
target class: Raw score of Memory assessment
closed: true
property:
  path: type
  has value: UO_0000189
  min count: 1
property:
  path: has value
  datatype: int
  name: Raw score of Memory assessment
  min count: 1
  max count: 1
  min inclusive: 0.0

Local norms of memory assessment Shape
type: NodeShape
type: numeric scale
target class: Local norms of memory assessment
closed: true
property:
  path: type
  has value: None
  min count: 1
property:
  path: has value
  datatype: int
  name: Local norms of memory assessment
  min count: 1
  max count: 1
  min inclusive: 0.0

Zscore of memory assessment Shape
type: NodeShape
type: numeric scale
target class: Z-score of memory assessment
closed: true
property:
  path: type
  has value: None
  min count: 1
property:
  path: has value
  datatype: int
  name: Z-score of memory assessment
  min count: 1
  max count: 1
  min inclusive: 0.0

Motor assessment scale score Shape
type: NodeShape
type: numeric scale
target class: Motor assessment scale score
closed: true
property:
  path: type
  has value: UO_0000189
  min count: 1
property:
  path: has value
  datatype: int
  name: Motor assessment scale score
  min count: 1
  max count: 1
  min inclusive: 0.0

Motor function Shape
type: NodeShape
target class: quantitative concept
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: Motor assessment scale score Shape
  min count: 1

CSF Amyloidbeta42 cut off dependent on the assay and for different preanalytical procedures in the cohort Shape
type: NodeShape
type: numeric scale
target class: CSF Amyloid-beta42 cut off dependent on the assay and for different pre-analytical procedures in the cohort.
closed: true
property:
  path: type
  has value: http://purl.bioontology.org/ontology/SNOMEDCT/258808001
  min count: 1
property:
  path: has value
  datatype: int
  name: CSF Amyloid-beta42 cut off dependent on the assay and for different pre-analytical procedures in the cohort.
  min count: 1
  max count: 1
  min inclusive: 0.0
property:
  path: has value
  datatype: int
  name: CSF Amyloid-beta42 cut off dependent on the assay and for different pre-analytical procedures in the cohort.
  min count: 1
  max count: 1
  max inclusive: 5000.0

Local CSF measures Shape
type: NodeShape
target class: quantitative concept
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: CSF Amyloidbeta42 cut off dependent on the assay and for different preanalytical procedures in the cohort Shape
  min count: 1
property:
  path: type
  has value: quantitative concept
property:
  path: SIO_000011
  node: Amyloid beta42 Shape
  min count: 1
target class: qualitative concept
property:
  path: type
  has value: qualitative concept
property:
  path: category
  node: Amyloid beta 42 status Shape
  min count: 1

Amyloid beta42 Shape
type: NodeShape
type: numeric scale
target class: Amyloid beta 42
closed: true
property:
  path: type
  has value: http://purl.bioontology.org/ontology/SNOMEDCT/258808001
  min count: 1
property:
  path: has value
  datatype: int
  name: Amyloid beta 42
  min count: 1
  max count: 1
  min inclusive: 0.0
property:
  path: has value
  datatype: int
  name: Amyloid beta 42
  min count: 1
  max count: 1
  max inclusive: 5000.0

Date of clinical diagnosis Shape
type: NodeShape
type: SIO_000418
closed: true
target class: Date of clinical diagnosis
property:
  path: type
  has value: Date of clinical diagnosis
property:
  path: has unit
  node: dateFormat

dateFormat
type: NodeShape
target class: Date
closed: true
property:
  path: type
  has value: Date
property:
  path: has value
  datatype: date
  alternative label: date YYYY-MM-DD
property:
  path: type
  has value: Date
property:
  path: has value
  datatype: date
  alternative label: date YYYY-MM-DD
property:
  path: type
  has value: Date
property:
  path: has value
  datatype: date
  alternative label: date YYYY-MM-DD

Diagnosis Shape
type: NodeShape
target class: temporal concept
property:
  path: type
  has value: temporal concept
property:
  path: SIO_000011
  node: Date of clinical diagnosis Shape
  min count: 1
target class: qualitative concept
property:
  path: type
  has value: qualitative concept
property:
  path: category
  node: Diagnosis of cognitive performance function Shape
  min count: 1
property:
  path: type
  has value: qualitative concept
property:
  path: category
  node: Type of dementia diagnosis Shape
  min count: 1
property:
  path: type
  has value: qualitative concept
property:
  path: category
  node: Staging according to a combination of amyloid pathology and cognitive impairment Shape
  min count: 1

Date of procedure observable entity Shape
type: NodeShape
type: SIO_000418
closed: true
target class: Date of procedure (observable entity)
property:
  path: type
  has value: Date of procedure (observable entity)
property:
  path: has unit
  node: dateFormat

collection date Shape
type: NodeShape
type: SIO_000418
closed: true
target class: collection date
property:
  path: type
  has value: collection date
property:
  path: has unit
  node: dateFormat

Sample related info Shape
type: NodeShape
target class: temporal concept
property:
  path: type
  has value: temporal concept
property:
  path: SIO_000011
  node: collection date Shape
  min count: 1

Finding related to biological sex Shape
type: NodeShape
type: category
closed: true
target class: Finding related to biological sex
xone:
  property:
    path: type
    has value: Finding related to biological sex
    min count: 2
    max count: 2
  property:
    path: type
    has value: Male
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: Finding related to biological sex
    min count: 2
    max count: 2
  property:
    path: type
    has value: Female
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: Finding related to biological sex
    min count: 2
    max count: 2
  property:
    path: type
    has value: Intersex
    min count: 2
    max count: 2
property:
  path: type
  in: Male
  in: Female
  in: Intersex
  in: Finding related to biological sex
  min count: 2

Diagnosis of cognitive performance function Shape
type: NodeShape
type: category
closed: true
target class: Diagnosis of cognitive performance, function
xone:
  property:
    path: type
    has value: Diagnosis of cognitive performance, function
    min count: 2
    max count: 2
  property:
    path: type
    has value: Normal cognition
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: Diagnosis of cognitive performance, function
    min count: 2
    max count: 2
  property:
    path: type
    has value: Mild cognitive impairment
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: Diagnosis of cognitive performance, function
    min count: 2
    max count: 2
  property:
    path: type
    has value: dementia (mild-moderate-severe)
    min count: 2
    max count: 2
property:
  path: type
  in: Normal cognition
  in: Mild cognitive impairment
  in: dementia (mild-moderate-severe)
  in: Diagnosis of cognitive performance, function
  min count: 2

Type of dementia diagnosis Shape
type: NodeShape
type: category
closed: true
target class: type of dementia diagnosis
xone:
  property:
    path: type
    has value: type of dementia diagnosis
    min count: 2
    max count: 2
  property:
    path: type
    has value: Alzheimer disease dementia
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: type of dementia diagnosis
    min count: 2
    max count: 2
  property:
    path: type
    has value: Dementia with Lewy bodies
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: type of dementia diagnosis
    min count: 2
    max count: 2
  property:
    path: type
    has value: Parkinson's disease dementia
    min count: 2
    max count: 2
property:
  path: type
  in: Alzheimer disease dementia
  in: Dementia with Lewy bodies
  in: Parkinson's disease dementia
  in: type of dementia diagnosis
  min count: 2

Staging according to a combination of amyloid pathology and cognitive impairment Shape
type: NodeShape
type: category
closed: true
target class: Staging according to a combination of amyloid pathology and cognitive impairment
xone:
  property:
    path: type
    has value: Staging according to a combination of amyloid pathology and cognitive impairment
    min count: 2
    max count: 2
  property:
    path: type
    has value: Combination of amyloid pathology and no cognitive impairment: Amyloid + NC/SCD
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: Staging according to a combination of amyloid pathology and cognitive impairment
    min count: 2
    max count: 2
  property:
    path: type
    has value: Combination of amyloid pathology and and cognitive impairment: Amyloid + MCI
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: Staging according to a combination of amyloid pathology and cognitive impairment
    min count: 2
    max count: 2
  property:
    path: type
    has value: Alzheimer disease dementia
    min count: 2
    max count: 2
property:
  path: type
  in: Combination of amyloid pathology and no cognitive impairment: Amyloid + NC/SCD
  in: Combination of amyloid pathology and and cognitive impairment: Amyloid + MCI
  in: Alzheimer disease dementia
  in: Staging according to a combination of amyloid pathology and cognitive impairment
  min count: 2

APOE 4 allele status Shape
type: NodeShape
type: category
closed: true
target class: APOE 4 allele status
xone:
  property:
    path: type
    has value: APOE 4 allele status
    min count: 2
    max count: 2
  property:
    path: type
    has value: true
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: APOE 4 allele status
    min count: 2
    max count: 2
  property:
    path: type
    has value: false
    min count: 2
    max count: 2
property:
  path: type
  in: true
  in: false
  in: APOE 4 allele status
  min count: 2

Genetics Shape
type: NodeShape
target class: qualitative concept
property:
  path: type
  has value: qualitative concept
property:
  path: category
  node: APOE 4 allele status Shape
  min count: 1
property:
  path: type
  has value: qualitative concept
property:
  path: category
  node: APOE genotype category Shape
  min count: 1
property:
  path: type
  has value: qualitative concept
property:
  path: category
  node: GBA Genotype status Shape
  min count: 1

APOE genotype category Shape
type: NodeShape
type: category
closed: true
target class: APOE genotype category
xone:
  property:
    path: type
    has value: APOE genotype category
    min count: 2
    max count: 2
  property:
    path: type
    has value: APOE allele E2E2
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: APOE genotype category
    min count: 2
    max count: 2
  property:
    path: type
    has value: APOE allele E2E3
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: APOE genotype category
    min count: 2
    max count: 2
  property:
    path: type
    has value: APOE allele E2E4
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: APOE genotype category
    min count: 2
    max count: 2
  property:
    path: type
    has value: APOE allele E3E3
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: APOE genotype category
    min count: 2
    max count: 2
  property:
    path: type
    has value: APOE allele E3E4
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: APOE genotype category
    min count: 2
    max count: 2
  property:
    path: type
    has value: APOE allele E4E4
    min count: 2
    max count: 2
property:
  path: type
  in: APOE allele E2E2
  in: APOE allele E2E3
  in: APOE allele E2E4
  in: APOE allele E3E3
  in: APOE allele E3E4
  in: APOE allele E4E4
  in: APOE genotype category
  min count: 2

GBA Genotype status Shape
type: NodeShape
type: category
closed: true
target class: GBA Genotype status
xone:
  property:
    path: type
    has value: GBA Genotype status
    min count: 2
    max count: 2
  property:
    path: type
    has value: true
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: GBA Genotype status
    min count: 2
    max count: 2
  property:
    path: type
    has value: false
    min count: 2
    max count: 2
property:
  path: type
  in: true
  in: false
  in: GBA Genotype status
  min count: 2

Amyloid beta 42 status Shape
type: NodeShape
type: category
closed: true
target class: Amyloid beta 42 status
xone:
  property:
    path: type
    has value: Amyloid beta 42 status
    min count: 2
    max count: 2
  property:
    path: type
    has value: true
    min count: 2
    max count: 2
xone:
  property:
    path: type
    has value: Amyloid beta 42 status
    min count: 2
    max count: 2
  property:
    path: type
    has value: false
    min count: 2
    max count: 2
property:
  path: type
  in: true
  in: false
  in: Amyloid beta 42 status
  min count: 2