@prefix OBI: <http://purl.obolibrary.org/obo>.
@prefix ncbi: <https://www.ncbi.nlm.nih.gov/gene/>.
@prefix LNC: <http://purl.bioontology.org/ontology/LNC>.
@prefix ex: <http://example/#> .
@prefix schema: <http://schema.org/> .
@prefix dash: <http://datashapes.org/dash#> . 
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> . 
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sh: <http://www.w3.org/ns/shacl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> . 
@prefix sio: <http://semanticscience.org/resource/>. 
@prefix snomed: <http://purl.bioontology.org/ontology/SNOMEDCT/>. 
@prefix UO: <http://purl.obolibrary.org/obo/>. 
@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
@prefix sty: <http://purl.bioontology.org/ontology/STY/>. 
@prefix loinc: <http://purl.bioontology.org/ontology/LNC/>. 
@prefix EPND: <http://epnd.org/ontology/>. 


sty:T081 rdfs:label "quantitative concept".
sty:T080 rdfs:label "qualitative concept".
sty:T079 rdfs:label "temporal concept".
OBI:0003076 rdfs:label "An age since birth at the time of a clinical visit.".
snomed:429019009 rdfs:label "Finding related to biological sex".
snomed:224288002 rdfs:label "Duration of formal education (observable entity)".
snomed:439272007 rdfs:label "Date of procedure (observable entity)".
snomed:459651000124107 rdfs:label "Montreal cognitive assessment score".
snomed:273617000 rdfs:label "Mini Mental State Examination".
snomed:273633002 rdfs:label "Motor assessment scale score".
ncbi:348 rdfs:label "APOE genotype category".
LNC:MTHU015751 rdfs:label "collection date ".


EPND:AgeAtSampleDate rdfs:label "Age when biosample was taken.".
EPND:ClinicalDiagnosis  rdfs:label "Diagnosis of cognitive performance, function".
EPND:ClinicalDiagnosisDate rdfs:label "Date of clinical diagnosis".
EPND:ClinicalDementiaDiagnosis rdfs:label "type of dementia diagnosis".
EPND:ADDiseaseStaging rdfs:label "Staging according to a combination of amyloid pathology and cognitive impairment".
EPND:MemoryAssessment rdfs:label "Memory assessment".
EPND:MemoryRawScore rdfs:label "Raw score of Memory assessment".
EPND:MemoryLocalNorms rdfs:label "Local norms of memory assessment".
EPND:standerdisedZScore rdfs:label "Z-score of memory assessment".
EPND:APOE4Status rdfs:label "APOE 4 allele status".
EPND:GBAGenotypeStatus rdfs:label "GBA Genotype status".
EPND:CSFAmyloidBeta42Cutoff rdfs:label "CSF Amyloid-beta42 cut off dependent on the assay and for different pre-analytical procedures in the cohort. ".
EPND:AmyloidBeta42Status  rdfs:label "Amyloid beta 42 status ".
EPND:AmyloidBeta42 rdfs:label "Amyloid beta 42".

snomed:248153007 rdfs:label "Male".
snomed:248152002 rdfs:label "Female".
snomed:32570691000036108 rdfs:label "Intersex".
EPND:NC rdfs:label "Normal cognition".
EPND:MCI rdfs:label "Mild cognitive impairment".
EPND:Dementia rdfs:label "dementia (mild-moderate-severe)".
EPND:ADDementia rdfs:label "Alzheimer disease dementia".
EPND:DLBDementia rdfs:label "Dementia with Lewy bodies ".
EPND:PDDementia rdfs:label "Parkinson's disease dementia".
EPND:PreclinicalAD rdfs:label "Combination of amyloid pathology and no cognitive impairment: Amyloid + NC/SCD".
EPND:ProdromalAD rdfs:label "Combination of amyloid pathology and and cognitive impairment: Amyloid + MCI".
EPND:ADDementia rdfs:label "Combination of amyloid pathology and dementia: Amyloid + dementia".
EPND:E2E2 rdfs:label "APOE allele E2E2".
EPND:E2E3 rdfs:label "APOE allele E2E3".
EPND:E2E4 rdfs:label "APOE allele E2E4".
EPND:E3E3 rdfs:label "APOE allele E3E3".
EPND:E3E4 rdfs:label "APOE allele E3E4".
EPND:E4E4 rdfs:label "APOE allele E4E4".
sio:SIO_000269 rdfs:label "true".
sio:SIO_000270 rdfs:label "false".
sio:SIO_000137 rdfs:label "category".
sio:SIO_000915 rdfs:label "numeric scale".
sio:SIO_000914 rdfs:label "binary scale".
sio:SIO_000221 rdfs:label "has unit".
sio:SIO_000300 rdfs:label "has value".
sio:SIO_000223 rdfs:label "has property".

ex:An_age_since_birth_measurement_datum_at_the_time_of_a_clinical_visit_Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass OBI:0003076;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue UO:UO_0000033; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name OBI:0003076; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name OBI:0003076; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:maxInclusive 130.0;
                            ].                                            

ex:Demographics_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:An_age_since_birth_measurement_datum_at_the_time_of_a_clinical_visit_Shape;
                                sh:minCount 1;            
                            ].
                            
ex:Age_when_biosample_was_taken__Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass EPND:AgeAtSampleDate;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue UO:UO_0000033; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name EPND:AgeAtSampleDate; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name EPND:AgeAtSampleDate; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:maxInclusive 130.0;
                            ].                                            

ex:Demographics_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Age_when_biosample_was_taken__Shape;
                                sh:minCount 1;            
                            ].
                            
ex:Duration_of_formal_education_observable_entity_Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass snomed:224288002;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue UO:UO_0000189; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name snomed:224288002; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name snomed:224288002; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:maxInclusive 130.0;
                            ].                                            

ex:Demographics_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Duration_of_formal_education_observable_entity_Shape;
                                sh:minCount 1;            
                            ].
                            
ex:Montreal_cognitive_assessment_score_Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass snomed:459651000124107;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue UO:UO_0000189; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name snomed:459651000124107; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name snomed:459651000124107; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:maxInclusive 31.0;
                            ].                                            

ex:Cognition_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Montreal_cognitive_assessment_score_Shape;
                                sh:minCount 1;            
                            ].
                            
ex:Mini_Mental_State_Examination_Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass snomed:273617000;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue UO:UO_0000189; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name snomed:273617000; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name snomed:273617000; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:maxInclusive 31.0;
                            ].                                            

ex:Cognition_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Mini_Mental_State_Examination_Shape;
                                sh:minCount 1;            
                            ].
                            
ex:Memory_assessment_Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass EPND:MemoryAssessment ;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue UO:UO_0000189; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name EPND:MemoryAssessment ; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ].                                            

ex:Cognition_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Memory_assessment_Shape;
                                sh:minCount 1;            
                            ].
                            
ex:Raw_score_of_memory_assessment_Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass EPND:MemoryRawScore;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue UO:UO_0000189; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name EPND:MemoryRawScore; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ].                                            

ex:Cognition_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Raw_score_of_memory_assessment_Shape;
                                sh:minCount 1;            
                            ].
                            
ex:Local_norms_of_memory_assessment_Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass EPND:MemoryLocalNorms;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue UO:None; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name EPND:MemoryLocalNorms; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ].                                            

ex:Cognition_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Local_norms_of_memory_assessment_Shape;
                                sh:minCount 1;            
                            ].
                            
ex:Zscore_of_memory_assessment_Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass EPND:standerdisedZScore;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue UO:None; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name EPND:standerdisedZScore; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ].                                            

ex:Cognition_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Zscore_of_memory_assessment_Shape;
                                sh:minCount 1;            
                            ].
                            
ex:Motor_assessment_scale_score_Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass snomed:273633002;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue UO:UO_0000189; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name snomed:273633002; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ].                                            

ex:Motor_function_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Motor_assessment_scale_score_Shape;
                                sh:minCount 1;            
                            ].
                            
ex:CSF_Amyloidbeta42_cut_off_dependent_on_the_assay_and_for_different_preanalytical_procedures_in_the_cohort__Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass EPND:CSFAmyloidBeta42Cutoff;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue snomed:258808001; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name EPND:CSFAmyloidBeta42Cutoff; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name EPND:CSFAmyloidBeta42Cutoff; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:maxInclusive 5000.0;
                            ].                                            

ex:Local_CSF_measures_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:CSF_Amyloidbeta42_cut_off_dependent_on_the_assay_and_for_different_preanalytical_procedures_in_the_cohort__Shape;
                                sh:minCount 1;            
                            ].
                            
ex:Amyloid_beta42__Shape a sh:NodeShape, sio:SIO_000915; #numeric
                            sh:targetClass EPND:AmyloidBeta42;
                            sh:closed true;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue snomed:258808001; 
                                sh:minCount 1;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name EPND:AmyloidBeta42; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:minInclusive 0.0; 
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000300; #has value
                                sh:datatype xsd:int; 
                                sh:name EPND:AmyloidBeta42; 
                                sh:minCount 1; 
                                sh:maxCount 1; 
                                sh:maxInclusive 5000.0;
                            ].                                            

ex:Local_CSF_measures_Shape a sh:NodeShape;
                            sh:targetClass sty:T081; #quantitative concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T081; #quantitative concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Amyloid_beta42__Shape;
                                sh:minCount 1;            
                            ].
                            
ex:Date_of_clinical_diagnosis_Shape a sh:NodeShape, sio:SIO_000418; #time instant
                            sh:closed true;
                            sh:targetClass EPND:ClinicalDiagnosisDate;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue EPND:ClinicalDiagnosisDate;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000221; #has unit
                                sh:node ex:dateFormat;
                            ].                                               

ex:dateFormat a sh:NodeShape;
                sh:targetClass schema:Date; #date in ISO 8601 date format
                sh:closed true;
                sh:property [
                    sh:path rdf:type ;
                    sh:hasValue schema:Date; #date in ISO 8601 date format
                ];
                sh:property [
                    sh:path sio:SIO_000300; #has_value
                    sh:datatype xsd:date;
                    skos:altLabel 'date YYYY-MM-DD';
                ].

ex:Diagnosis_Shape a sh:NodeShape;
                            sh:targetClass sty:T079; #temporal concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T079; #temporal concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Date_of_clinical_diagnosis_Shape;
                                sh:minCount 1;
                            ].            
                    
ex:Date_of_procedure_observable_entity_Shape a sh:NodeShape, sio:SIO_000418; #time instant
                            sh:closed true;
                            sh:targetClass snomed:439272007;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue snomed:439272007;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000221; #has unit
                                sh:node ex:dateFormat;
                            ].                                               

ex:dateFormat a sh:NodeShape;
                sh:targetClass schema:Date; #date in ISO 8601 date format
                sh:closed true;
                sh:property [
                    sh:path rdf:type ;
                    sh:hasValue schema:Date; #date in ISO 8601 date format
                ];
                sh:property [
                    sh:path sio:SIO_000300; #has_value
                    sh:datatype xsd:date;
                    skos:altLabel 'date YYYY-MM-DD';
                ].

ex:Cognition_Shape a sh:NodeShape;
                            sh:targetClass sty:T079; #temporal concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T079; #temporal concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:Date_of_procedure_observable_entity_Shape;
                                sh:minCount 1;
                            ].            
                    
ex:collection_date__Shape a sh:NodeShape, sio:SIO_000418; #time instant
                            sh:closed true;
                            sh:targetClass LNC:MTHU015751;
                            sh:property [ 
                                sh:path rdf:type; 
                                sh:hasValue LNC:MTHU015751;
                            ];
                            sh:property [ 
                                sh:path sio:SIO_000221; #has unit
                                sh:node ex:dateFormat;
                            ].                                               

ex:dateFormat a sh:NodeShape;
                sh:targetClass schema:Date; #date in ISO 8601 date format
                sh:closed true;
                sh:property [
                    sh:path rdf:type ;
                    sh:hasValue schema:Date; #date in ISO 8601 date format
                ];
                sh:property [
                    sh:path sio:SIO_000300; #has_value
                    sh:datatype xsd:date;
                    skos:altLabel 'date YYYY-MM-DD';
                ].

ex:Sample_related_info_Shape a sh:NodeShape;
                            sh:targetClass sty:T079; #temporal concept
                            sh:property [
                                sh:path rdf:type ;
                                sh:hasValue sty:T079; #temporal concept
                            ];
                            sh:property [
                                sh:path sio:SIO_000011; #is attribute of
                                sh:node ex:collection_date__Shape;
                                sh:minCount 1;
                            ].            
                    
 
ex:Finding_related_to_biological_sex_Shape  a   sh:NodeShape, sio:SIO_000137; #category
                                sh:closed true;
                                sh:targetClass snomed:429019009;
                                sh:xone 
                                ( 
                                   [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue snomed:429019009;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue snomed:248153007;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue snomed:429019009;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  snomed:248152002;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue snomed:429019009;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  snomed:32570691000036108;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]
                                );
                                sh:property [
                                    sh:path rdf:type ;
                                    sh:in ( snomed:248153007 snomed:248152002 snomed:32570691000036108 snomed:429019009 ) ;
                                    sh:minCount 2; # columnClass and valueClass combination 
                                ].
                                               
ex:Demographics_Shape a sh:NodeShape;
                        sh:targetClass sty:T080; #qualitative concept
                        sh:property [
                            sh:path rdf:type ;
                            sh:hasValue sty:T080; #qualitative concept
                        ];
                        sh:property [
                            sh:path sio:SIO_000137; #is attribute of
                            sh:node ex:Finding_related_to_biological_sex_Shape;
                            sh:minCount 1;  
                        ].
                                
 
ex:Diagnosis_of_cognitive_performance_function_Shape  a   sh:NodeShape, sio:SIO_000137; #category
                                sh:closed true;
                                sh:targetClass EPND:ClinicalDiagnosis ;
                                sh:xone 
                                ( 
                                   [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:ClinicalDiagnosis ;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:NC;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:ClinicalDiagnosis ;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  EPND:MCI;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:ClinicalDiagnosis ;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  EPND:Dementia;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]
                                );
                                sh:property [
                                    sh:path rdf:type ;
                                    sh:in ( EPND:NC EPND:MCI EPND:Dementia EPND:ClinicalDiagnosis  ) ;
                                    sh:minCount 2; # columnClass and valueClass combination 
                                ].
                                               
ex:Diagnosis_Shape a sh:NodeShape;
                        sh:targetClass sty:T080; #qualitative concept
                        sh:property [
                            sh:path rdf:type ;
                            sh:hasValue sty:T080; #qualitative concept
                        ];
                        sh:property [
                            sh:path sio:SIO_000137; #is attribute of
                            sh:node ex:Diagnosis_of_cognitive_performance_function_Shape;
                            sh:minCount 1;  
                        ].
                                
 
ex:Type_of_dementia_diagnosis_Shape  a   sh:NodeShape, sio:SIO_000137; #category
                                sh:closed true;
                                sh:targetClass EPND:ClinicalDementiaDiagnosis;
                                sh:xone 
                                ( 
                                   [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:ClinicalDementiaDiagnosis;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:ADDementia;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:ClinicalDementiaDiagnosis;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  EPND:DLBDementia;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:ClinicalDementiaDiagnosis;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  EPND:PDDementia;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]
                                );
                                sh:property [
                                    sh:path rdf:type ;
                                    sh:in ( EPND:ADDementia EPND:DLBDementia EPND:PDDementia EPND:ClinicalDementiaDiagnosis ) ;
                                    sh:minCount 2; # columnClass and valueClass combination 
                                ].
                                               
ex:Diagnosis_Shape a sh:NodeShape;
                        sh:targetClass sty:T080; #qualitative concept
                        sh:property [
                            sh:path rdf:type ;
                            sh:hasValue sty:T080; #qualitative concept
                        ];
                        sh:property [
                            sh:path sio:SIO_000137; #is attribute of
                            sh:node ex:Type_of_dementia_diagnosis_Shape;
                            sh:minCount 1;  
                        ].
                                
 
ex:Staging_according_to_a_combination_of_amyloid_pathology_and_cognitive_impairment_Shape  a   sh:NodeShape, sio:SIO_000137; #category
                                sh:closed true;
                                sh:targetClass EPND:ADDiseaseStaging;
                                sh:xone 
                                ( 
                                   [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:ADDiseaseStaging;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:PreclinicalAD;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:ADDiseaseStaging;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  EPND:ProdromalAD;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:ADDiseaseStaging;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  EPND:ADDementia;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]
                                );
                                sh:property [
                                    sh:path rdf:type ;
                                    sh:in ( EPND:PreclinicalAD EPND:ProdromalAD EPND:ADDementia EPND:ADDiseaseStaging ) ;
                                    sh:minCount 2; # columnClass and valueClass combination 
                                ].
                                               
ex:Diagnosis_Shape a sh:NodeShape;
                        sh:targetClass sty:T080; #qualitative concept
                        sh:property [
                            sh:path rdf:type ;
                            sh:hasValue sty:T080; #qualitative concept
                        ];
                        sh:property [
                            sh:path sio:SIO_000137; #is attribute of
                            sh:node ex:Staging_according_to_a_combination_of_amyloid_pathology_and_cognitive_impairment_Shape;
                            sh:minCount 1;  
                        ].
                                
 
ex:APOE_4_allele_status_Shape  a   sh:NodeShape, sio:SIO_000137; #category
                                sh:closed true;
                                sh:targetClass EPND:APOE4Status;
                                sh:xone 
                                ( 
                                   [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:APOE4Status;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  sio:SIO_000269;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:APOE4Status;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  sio:SIO_000270  ;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]
                                );
                                sh:property [
                                    sh:path rdf:type ;
                                    sh:in (  sio:SIO_000269 sio:SIO_000270   EPND:APOE4Status ) ;
                                    sh:minCount 2; # columnClass and valueClass combination 
                                ].
                                               
ex:Genetics_Shape a sh:NodeShape;
                        sh:targetClass sty:T080; #qualitative concept
                        sh:property [
                            sh:path rdf:type ;
                            sh:hasValue sty:T080; #qualitative concept
                        ];
                        sh:property [
                            sh:path sio:SIO_000137; #is attribute of
                            sh:node ex:APOE_4_allele_status_Shape;
                            sh:minCount 1;  
                        ].
                                
 
ex:APOE_genotype_category_Shape  a   sh:NodeShape, sio:SIO_000137; #category
                                sh:closed true;
                                sh:targetClass ncbi:348;
                                sh:xone 
                                ( 
                                   [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue ncbi:348;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:E2E2;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue ncbi:348;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  EPND:E2E3;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue ncbi:348;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  EPND:E2E4;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue ncbi:348;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  EPND:E3E3;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue ncbi:348;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  EPND:E3E4;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue ncbi:348;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  EPND:E4E4;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]
                                );
                                sh:property [
                                    sh:path rdf:type ;
                                    sh:in ( EPND:E2E2 EPND:E2E3 EPND:E2E4 EPND:E3E3 EPND:E3E4 EPND:E4E4 ncbi:348 ) ;
                                    sh:minCount 2; # columnClass and valueClass combination 
                                ].
                                               
ex:Genetics_Shape a sh:NodeShape;
                        sh:targetClass sty:T080; #qualitative concept
                        sh:property [
                            sh:path rdf:type ;
                            sh:hasValue sty:T080; #qualitative concept
                        ];
                        sh:property [
                            sh:path sio:SIO_000137; #is attribute of
                            sh:node ex:APOE_genotype_category_Shape;
                            sh:minCount 1;  
                        ].
                                
 
ex:GBA_Genotype_status_Shape  a   sh:NodeShape, sio:SIO_000137; #category
                                sh:closed true;
                                sh:targetClass EPND:GBAGenotypeStatus;
                                sh:xone 
                                ( 
                                   [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:GBAGenotypeStatus;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  sio:SIO_000269;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:GBAGenotypeStatus;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  sio:SIO_000270  ;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]
                                );
                                sh:property [
                                    sh:path rdf:type ;
                                    sh:in (  sio:SIO_000269 sio:SIO_000270   EPND:GBAGenotypeStatus ) ;
                                    sh:minCount 2; # columnClass and valueClass combination 
                                ].
                                               
ex:Genetics_Shape a sh:NodeShape;
                        sh:targetClass sty:T080; #qualitative concept
                        sh:property [
                            sh:path rdf:type ;
                            sh:hasValue sty:T080; #qualitative concept
                        ];
                        sh:property [
                            sh:path sio:SIO_000137; #is attribute of
                            sh:node ex:GBA_Genotype_status_Shape;
                            sh:minCount 1;  
                        ].
                                
 
ex:Amyloid_beta_42_status__Shape  a   sh:NodeShape, sio:SIO_000137; #category
                                sh:closed true;
                                sh:targetClass EPND:AmyloidBeta42Status ;
                                sh:xone 
                                ( 
                                   [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:AmyloidBeta42Status ;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  sio:SIO_000269;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]    [
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue EPND:AmyloidBeta42Status ;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                        sh:property [
                                                sh:path rdf:type;
                                                sh:hasValue  sio:SIO_000270  ;
                                                sh:minCount 2;
                                                sh:maxCount 2;
                                        ];
                                    ]
                                );
                                sh:property [
                                    sh:path rdf:type ;
                                    sh:in (  sio:SIO_000269 sio:SIO_000270   EPND:AmyloidBeta42Status  ) ;
                                    sh:minCount 2; # columnClass and valueClass combination 
                                ].
                                               
ex:Local_CSF_measures_Shape a sh:NodeShape;
                        sh:targetClass sty:T080; #qualitative concept
                        sh:property [
                            sh:path rdf:type ;
                            sh:hasValue sty:T080; #qualitative concept
                        ];
                        sh:property [
                            sh:path sio:SIO_000137; #is attribute of
                            sh:node ex:Amyloid_beta_42_status__Shape;
                            sh:minCount 1;  
                        ].