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" ], "text/plain": [ "| \n", " | GSM1846906 | \n", "GSM1846907 | \n", "GSM1846905 | \n", "GSM1846909 | \n", "GSM1846910 | \n", "GSM1846915 | \n", "GSM1846919 | \n", "GSM1846914 | \n", "GSM1846911 | \n", "GSM1846912 | \n", "GSM1846913 | \n", "GSM1846920 | \n", "GSM1846916 | \n", "GSM1846908 | \n", "GSM1846918 | \n", "GSM1846917 | \n", "GSM1846904 | \n", "GSM1846921 | \n", "
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A1BG | \n", "280 | \n", "84 | \n", "334 | \n", "170 | \n", "424 | \n", "503 | \n", "221 | \n", "619 | \n", "932 | \n", "561 | \n", "985 | \n", "332 | \n", "222 | \n", "354 | \n", "282 | \n", "291 | \n", "167 | \n", "268 | \n", "
| A1CF | \n", "2 | \n", "2 | \n", "11 | \n", "10 | \n", "4 | \n", "2 | \n", "6 | \n", "3 | \n", "10 | \n", "4 | \n", "3 | \n", "9 | \n", "7 | \n", "10 | \n", "2 | \n", "6 | \n", "4 | \n", "3 | \n", "
| A2M | \n", "8 | \n", "40 | \n", "8 | \n", "49 | \n", "10704 | \n", "10969 | \n", "5479 | \n", "11670 | \n", "10334 | \n", "7303 | \n", "25299 | \n", "4313 | \n", "3252 | \n", "72 | \n", "3021 | \n", "2109 | \n", "40 | \n", "3438 | \n", "
| A2ML1 | \n", "8 | \n", "4 | \n", "18 | \n", "25 | \n", "7 | \n", "5 | \n", "16 | \n", "7 | \n", "17 | \n", "15 | \n", "5 | \n", "10 | \n", "8 | \n", "11 | \n", "9 | \n", "7 | \n", "14 | \n", "9 | \n", "
| A2MP1 | \n", "2 | \n", "0 | \n", "1 | \n", "2 | \n", "34 | \n", "26 | \n", "11 | \n", "31 | \n", "29 | \n", "14 | \n", "50 | \n", "20 | \n", "10 | \n", "2 | \n", "6 | \n", "10 | \n", "1 | \n", "2 | \n", "
| \n", " | Sample Title | \n", "cell type | \n", "infected shrna | \n", "melanoma mutation | \n", "passage | \n", "
|---|---|---|---|---|---|
| Sample_geo_accession | \n", "\n", " | \n", " | \n", " | \n", " | \n", " |
| GSM1846906 | \n", "MM13_shKMT2D_RNAseq_rp3 | \n", "patient derived xenograft cells | \n", "shKMT2D | \n", "NRASQ61L | \n", "2 | \n", "
| GSM1846907 | \n", "MM13_shLuc_RNAseq_rp1 | \n", "patient derived xenograft cells | \n", "shLuc | \n", "NRASQ61L | \n", "2 | \n", "
| GSM1846905 | \n", "MM13_shKMT2D_RNAseq_rp2 | \n", "patient derived xenograft cells | \n", "shKMT2D | \n", "NRASQ61L | \n", "2 | \n", "
| GSM1846909 | \n", "MM13_shLuc_RNAseq_rp3 | \n", "patient derived xenograft cells | \n", "shLuc | \n", "NRASQ61L | \n", "2 | \n", "
| GSM1846910 | \n", "MM16_shKMT2D_RNAseq_rp1 | \n", "patient derived xenograft cells | \n", "shKMT2D | \n", "NRASQ61K | \n", "2 | \n", "
| GSM1846915 | \n", "MM16_shLuc_RNAseq_rp3 | \n", "patient derived xenograft cells | \n", "shLuc | \n", "NRASQ61K | \n", "2 | \n", "
| GSM1846919 | \n", "MM27_shLuc_RNAseq_rp1 | \n", "patient derived xenograft cells | \n", "shLuc | \n", "BRAFV600E | \n", "2 | \n", "
| GSM1846914 | \n", "MM16_shLuc_RNAseq_rp2 | \n", "patient derived xenograft cells | \n", "shLuc | \n", "NRASQ61K | \n", "2 | \n", "
| GSM1846911 | \n", "MM16_shKMT2D_RNAseq_rp2 | \n", "patient derived xenograft cells | \n", "shKMT2D | \n", "NRASQ61K | \n", "2 | \n", "
| GSM1846912 | \n", "MM16_shKMT2D_RNAseq_rp3 | \n", "patient derived xenograft cells | \n", "shKMT2D | \n", "NRASQ61K | \n", "2 | \n", "
| GSM1846913 | \n", "MM16_shLuc_RNAseq_rp1 | \n", "patient derived xenograft cells | \n", "shLuc | \n", "NRASQ61K | \n", "2 | \n", "
| GSM1846920 | \n", "MM27_shLuc_RNAseq_rp2 | \n", "patient derived xenograft cells | \n", "shLuc | \n", "BRAFV600E | \n", "2 | \n", "
| GSM1846916 | \n", "MM27_shKMT2D_RNAseq_rp1 | \n", "patient derived xenograft cells | \n", "shKMT2D | \n", "BRAFV600E | \n", "2 | \n", "
| GSM1846908 | \n", "MM13_shLuc_RNAseq_rp2 | \n", "patient derived xenograft cells | \n", "shLuc | \n", "NRASQ61L | \n", "2 | \n", "
| GSM1846918 | \n", "MM27_shKMT2D_RNAseq_rp3 | \n", "patient derived xenograft cells | \n", "shKMT2D | \n", "BRAFV600E | \n", "2 | \n", "
| GSM1846917 | \n", "MM27_shKMT2D_RNAseq_rp2 | \n", "patient derived xenograft cells | \n", "shKMT2D | \n", "BRAFV600E | \n", "2 | \n", "
| GSM1846904 | \n", "MM13_shKMT2D_RNAseq_rp1 | \n", "patient derived xenograft cells | \n", "shKMT2D | \n", "NRASQ61L | \n", "2 | \n", "
| GSM1846921 | \n", "MM27_shLuc_RNAseq_rp3 | \n", "patient derived xenograft cells | \n", "shLuc | \n", "BRAFV600E | \n", "2 | \n", "
| \n", " | logFC | \n", "AveExpr | \n", "P-value | \n", "FDR | \n", "
|---|---|---|---|---|
| Gene | \n", "\n", " | \n", " | \n", " | \n", " |
| *CSF3 | \n", "4.98 | \n", "-0.61 | \n", "7.988621e-08 | \n", "0.000702 | \n", "
| *DEFB103B | \n", "4.66 | \n", "2.08 | \n", "1.038521e-07 | \n", "0.000702 | \n", "
| *ELOVL2 | \n", "-3.31 | \n", "4.45 | \n", "1.063014e-07 | \n", "0.000702 | \n", "
| *KIF20A | \n", "-2.83 | \n", "5.20 | \n", "1.187809e-07 | \n", "0.000702 | \n", "
| *NDC80 | \n", "-2.76 | \n", "4.23 | \n", "1.675947e-07 | \n", "0.000702 | \n", "
| *CDK1 | \n", "-2.61 | \n", "5.19 | \n", "2.099340e-07 | \n", "0.000702 | \n", "
| *DEFB103A | \n", "4.64 | \n", "1.08 | \n", "2.162027e-07 | \n", "0.000702 | \n", "
| *NCAPG | \n", "-2.54 | \n", "4.93 | \n", "2.271055e-07 | \n", "0.000702 | \n", "
| *SPAG5 | \n", "-2.20 | \n", "5.14 | \n", "2.379365e-07 | \n", "0.000702 | \n", "
| *NUF2 | \n", "-2.59 | \n", "4.07 | \n", "2.670675e-07 | \n", "0.000702 | \n", "
| *PADI3 | \n", "-3.42 | \n", "1.03 | \n", "2.741276e-07 | \n", "0.000702 | \n", "
| *RRM2 | \n", "-3.14 | \n", "5.16 | \n", "2.749318e-07 | \n", "0.000702 | \n", "
| *KIF23 | \n", "-2.13 | \n", "5.38 | \n", "2.794625e-07 | \n", "0.000702 | \n", "
| *PBK | \n", "-2.71 | \n", "4.34 | \n", "2.893579e-07 | \n", "0.000702 | \n", "
| *CDC25C | \n", "-2.99 | \n", "1.86 | \n", "2.989265e-07 | \n", "0.000702 | \n", "
| *BMP2 | \n", "2.30 | \n", "5.57 | \n", "3.558851e-07 | \n", "0.000751 | \n", "
| *CDKN2C | \n", "-3.65 | \n", "2.64 | \n", "3.731138e-07 | \n", "0.000751 | \n", "
| *CDKN3 | \n", "-2.80 | \n", "3.87 | \n", "4.323315e-07 | \n", "0.000751 | \n", "
| *CDC6 | \n", "-2.46 | \n", "4.69 | \n", "4.338553e-07 | \n", "0.000751 | \n", "
| *TMEM71 | \n", "-2.47 | \n", "2.69 | \n", "4.510800e-07 | \n", "0.000751 | \n", "
| *PPL | \n", "-2.60 | \n", "4.86 | \n", "4.842187e-07 | \n", "0.000751 | \n", "
| *ZWINT | \n", "-2.20 | \n", "4.88 | \n", "4.929842e-07 | \n", "0.000751 | \n", "
| *CCNB1 | \n", "-1.84 | \n", "6.13 | \n", "5.770819e-07 | \n", "0.000751 | \n", "
| *FABP3 | \n", "-2.74 | \n", "1.95 | \n", "5.888300e-07 | \n", "0.000751 | \n", "
| *IL1B | \n", "2.10 | \n", "7.56 | \n", "5.888948e-07 | \n", "0.000751 | \n", "
| *MAPK8IP2 | \n", "-2.25 | \n", "2.78 | \n", "6.164419e-07 | \n", "0.000751 | \n", "
| *NUSAP1 | \n", "-2.60 | \n", "5.30 | \n", "6.166006e-07 | \n", "0.000751 | \n", "
| *LMNB1 | \n", "-2.21 | \n", "4.84 | \n", "6.320962e-07 | \n", "0.000751 | \n", "
| *GATSL3 | \n", "2.35 | \n", "4.13 | \n", "6.469384e-07 | \n", "0.000751 | \n", "
| *NMU | \n", "-4.08 | \n", "-1.83 | \n", "6.883912e-07 | \n", "0.000751 | \n", "
| *GPSM2 | \n", "-2.73 | \n", "4.30 | \n", "7.020776e-07 | \n", "0.000751 | \n", "
| *FAM72B | \n", "-2.55 | \n", "2.36 | \n", "7.465090e-07 | \n", "0.000751 | \n", "
| *TYMS | \n", "-1.80 | \n", "6.03 | \n", "8.134943e-07 | \n", "0.000751 | \n", "
| *NEIL3 | \n", "-2.61 | \n", "1.29 | \n", "8.255161e-07 | \n", "0.000751 | \n", "
| *CCNB2 | \n", "-2.39 | \n", "4.71 | \n", "8.270063e-07 | \n", "0.000751 | \n", "
| *PPM1E | \n", "-3.42 | \n", "0.46 | \n", "8.708551e-07 | \n", "0.000751 | \n", "
| *APOBEC3B | \n", "-3.12 | \n", "3.18 | \n", "8.734778e-07 | \n", "0.000751 | \n", "
| *FAM111B | \n", "-3.04 | \n", "3.40 | \n", "9.140102e-07 | \n", "0.000751 | \n", "
| *CENPA | \n", "-2.40 | \n", "3.08 | \n", "9.485570e-07 | \n", "0.000751 | \n", "
| *HMMR | \n", "-2.59 | \n", "4.07 | \n", "9.776581e-07 | \n", "0.000751 | \n", "
| *OLFML2A | \n", "-3.33 | \n", "2.91 | \n", "9.930159e-07 | \n", "0.000751 | \n", "
| *DLGAP5 | \n", "-2.50 | \n", "4.55 | \n", "9.949078e-07 | \n", "0.000751 | \n", "
| *KIFC1 | \n", "-2.73 | \n", "5.18 | \n", "1.045586e-06 | \n", "0.000751 | \n", "
| *NEK2 | \n", "-2.58 | \n", "3.69 | \n", "1.063784e-06 | \n", "0.000751 | \n", "
| *GMNN | \n", "-1.88 | \n", "5.47 | \n", "1.066635e-06 | \n", "0.000751 | \n", "
| *TPX2 | \n", "-2.35 | \n", "6.21 | \n", "1.071492e-06 | \n", "0.000751 | \n", "
| *TTK | \n", "-2.51 | \n", "4.15 | \n", "1.083748e-06 | \n", "0.000751 | \n", "
| *RAD51 | \n", "-2.53 | \n", "2.95 | \n", "1.086303e-06 | \n", "0.000751 | \n", "
| *SKA3 | \n", "-2.40 | \n", "3.63 | \n", "1.088784e-06 | \n", "0.000751 | \n", "
| *SOD2 | \n", "2.37 | \n", "9.24 | \n", "1.091390e-06 | \n", "0.000751 | \n", "
| *SPC25 | \n", "-2.52 | \n", "3.03 | \n", "1.139658e-06 | \n", "0.000751 | \n", "
| *CDC45 | \n", "-2.40 | \n", "3.52 | \n", "1.157999e-06 | \n", "0.000751 | \n", "
| *ANGPTL4 | \n", "3.32 | \n", "1.41 | \n", "1.164318e-06 | \n", "0.000751 | \n", "
| *ITGA7 | \n", "-1.97 | \n", "5.30 | \n", "1.187852e-06 | \n", "0.000751 | \n", "
| *CEP55 | \n", "-2.69 | \n", "5.62 | \n", "1.187904e-06 | \n", "0.000751 | \n", "
| *CLDN1 | \n", "2.59 | \n", "2.23 | \n", "1.193546e-06 | \n", "0.000751 | \n", "
| *CDCA8 | \n", "-2.79 | \n", "3.47 | \n", "1.236268e-06 | \n", "0.000759 | \n", "
| *CENPF | \n", "-2.22 | \n", "6.78 | \n", "1.248938e-06 | \n", "0.000759 | \n", "
| *AC004381.6 | \n", "-2.05 | \n", "2.67 | \n", "1.345565e-06 | \n", "0.000804 | \n", "
| *IQGAP3 | \n", "-2.24 | \n", "5.04 | \n", "1.431250e-06 | \n", "0.000822 | \n", "
| *GINS2 | \n", "-1.99 | \n", "3.32 | \n", "1.432323e-06 | \n", "0.000822 | \n", "
| *DEPDC1B | \n", "-2.38 | \n", "2.58 | \n", "1.446979e-06 | \n", "0.000822 | \n", "
| *CCNA2 | \n", "-2.52 | \n", "4.36 | \n", "1.531383e-06 | \n", "0.000852 | \n", "
| *KIF11 | \n", "-2.46 | \n", "5.22 | \n", "1.546659e-06 | \n", "0.000852 | \n", "
| *NCAPG2 | \n", "-2.61 | \n", "4.43 | \n", "1.671211e-06 | \n", "0.000885 | \n", "
| *FBXO43 | \n", "-2.65 | \n", "0.59 | \n", "1.675541e-06 | \n", "0.000885 | \n", "
| *SDC2 | \n", "2.77 | \n", "3.28 | \n", "1.706618e-06 | \n", "0.000885 | \n", "
| *MALL | \n", "-3.22 | \n", "2.11 | \n", "1.715640e-06 | \n", "0.000885 | \n", "
| *CDCA3 | \n", "-2.56 | \n", "3.62 | \n", "1.747172e-06 | \n", "0.000885 | \n", "
| *HJURP | \n", "-2.77 | \n", "5.30 | \n", "1.758300e-06 | \n", "0.000885 | \n", "
| *CNTRL | \n", "-1.76 | \n", "4.76 | \n", "1.788160e-06 | \n", "0.000887 | \n", "
| *EXO1 | \n", "-2.60 | \n", "3.27 | \n", "1.901500e-06 | \n", "0.000931 | \n", "
| *CIT | \n", "-2.78 | \n", "5.35 | \n", "1.970083e-06 | \n", "0.000951 | \n", "
| *KIF2C | \n", "-2.70 | \n", "4.63 | \n", "2.113863e-06 | \n", "0.000970 | \n", "
| *TCF19 | \n", "-2.56 | \n", "4.94 | \n", "2.118624e-06 | \n", "0.000970 | \n", "
| *FAM46B | \n", "-2.48 | \n", "0.32 | \n", "2.137942e-06 | \n", "0.000970 | \n", "
| *UBE2T | \n", "-1.84 | \n", "4.03 | \n", "2.151694e-06 | \n", "0.000970 | \n", "
| *RAD51AP1 | \n", "-2.11 | \n", "3.39 | \n", "2.198760e-06 | \n", "0.000970 | \n", "
| *FAM64A | \n", "-2.88 | \n", "3.33 | \n", "2.220530e-06 | \n", "0.000970 | \n", "
| *MELK | \n", "-2.30 | \n", "4.26 | \n", "2.230197e-06 | \n", "0.000970 | \n", "
| *TNFAIP6 | \n", "4.34 | \n", "-1.47 | \n", "2.231709e-06 | \n", "0.000970 | \n", "
| *NEURL1B | \n", "-4.02 | \n", "1.57 | \n", "2.257868e-06 | \n", "0.000970 | \n", "
| *WDR76 | \n", "-2.67 | \n", "3.42 | \n", "2.400674e-06 | \n", "0.001019 | \n", "
| *BORA | \n", "-1.90 | \n", "3.09 | \n", "2.437616e-06 | \n", "0.001023 | \n", "
| *OSBP2 | \n", "-1.96 | \n", "4.10 | \n", "2.497887e-06 | \n", "0.001036 | \n", "
| *SGO1 | \n", "-2.40 | \n", "2.61 | \n", "2.629448e-06 | \n", "0.001077 | \n", "
| *PTPRH | \n", "-1.99 | \n", "2.87 | \n", "2.749500e-06 | \n", "0.001114 | \n", "
| *ARNT2 | \n", "-2.16 | \n", "2.94 | \n", "2.820754e-06 | \n", "0.001125 | \n", "
| *FAM72A | \n", "-2.10 | \n", "2.40 | \n", "2.842528e-06 | \n", "0.001125 | \n", "
| *GTSE1 | \n", "-2.49 | \n", "4.25 | \n", "2.993814e-06 | \n", "0.001160 | \n", "
| *FAM72D | \n", "-2.36 | \n", "1.78 | \n", "2.996688e-06 | \n", "0.001160 | \n", "
| *PHGDH | \n", "-2.19 | \n", "5.14 | \n", "3.037237e-06 | \n", "0.001163 | \n", "
| *PLK4 | \n", "-2.16 | \n", "2.92 | \n", "3.175932e-06 | \n", "0.001192 | \n", "
| *PRC1 | \n", "-2.09 | \n", "6.54 | \n", "3.179518e-06 | \n", "0.001192 | \n", "
| *MCM3 | \n", "-1.63 | \n", "7.21 | \n", "3.306676e-06 | \n", "0.001217 | \n", "
| *IL32 | \n", "2.80 | \n", "2.02 | \n", "3.315727e-06 | \n", "0.001217 | \n", "
| *CDCA2 | \n", "-2.38 | \n", "3.84 | \n", "3.387261e-06 | \n", "0.001225 | \n", "
| *HS3ST2 | \n", "2.60 | \n", "-0.44 | \n", "3.407397e-06 | \n", "0.001225 | \n", "
| *HELLS | \n", "-1.89 | \n", "3.99 | \n", "3.465145e-06 | \n", "0.001233 | \n", "
| *KIF15 | \n", "-2.68 | \n", "3.06 | \n", "3.500165e-06 | \n", "0.001233 | \n", "