CYP2E1 compound UGT2B15 CYP2E1 compound PLA2G2A CYP2E1 compound HSD11B1 MAPK1 inhibition HRAS MAPK1 phosphorylation HRAS MAPK1 activation ESR1 MAPK1 phosphorylation ESR1 MAPK1 activation PLA2G2A MAPK1 activation FOS MAPK1 indirect effect FOS MAPK1 phosphorylation FOS MAPK1 expression FOS MAPK1 activation CREB3L3 MAPK1 indirect effect CREB3L3 MAPK1 phosphorylation CREB3L3 HRAS activation MAPK1 HRAS indirect effect MAPK1 HRAS phosphorylation MAPK1 HRAS indirect effect FOS FGFR2 activation HRAS FGFR2 indirect effect HRAS ESR1 expression TFF1 ESR1 binding/association FOS PLA2G2A compound CYP2E1 FOS expression MMP1 HSD11B1 compound UGT2B15 NPY activation NPY1R NPY activation SUCNR1 CREB3L3 expression FOS CREB3L3 expression NPY CREB3L3 state change CREB3L3