"pert","cell","type","trend","WTCS","WTCS_Pval","WTCS_FDR","NCS","NCSct","N_upset","N_downset","t_gn_sym","MOAss","PCIDss","target_count"
"foretinib","MCF7","trt_cp","up",0.70077988988631,1.30120225430897e-05,6.23466946078869e-05,1.38920847421079,0.94368949954922,22,2,"ABL2; ALK; AURKC; AXL; BLK; BTK; CDK14; CDK15; CDK19; CDK7; CHEK2; DDR1; DDR2; EPHA1; EPHA2; EPHA3; EPHA4; EPHA5; EPHA6; EPHA7; EPHA8; EPHB1; EPHB2; EPHB3; EPHB4; EPHB6; FER; FGR; FLT4; FYN; HCK; HGF; HIPK3; HIPK4; INSRR; ITK; KDR; MAP2K1; MAP2K2; MAP2K5; MAP3K12; MAP3K13; MAP3K19; MAP4K1; MAP4K5; MAPK13; MAPK15; MERTK; MKNK1; MKNK2; MLTK; MST1R; MUSK; NTRK1; NTRK2; NTRK3; PDGFRA; PIP4K2C; PLK4; PTK2B; PTK6; RET; RIPK2; ROS1; SLK; SRMS; STK10; TEK; TIE1; TNK1; TYRO3; YES1",NA,"42642645",71
"foretinib","SKBR3","trt_cp","up",0.514617857020842,2.11064579712325e-05,6.23466946078869e-05,1.07258080352203,0.94368949954922,22,2,"ABL2; ALK; AURKC; AXL; BLK; BTK; CDK14; CDK15; CDK19; CDK7; CHEK2; DDR1; DDR2; EPHA1; EPHA2; EPHA3; EPHA4; EPHA5; EPHA6; EPHA7; EPHA8; EPHB1; EPHB2; EPHB3; EPHB4; EPHB6; FER; FGR; FLT4; FYN; HCK; HGF; HIPK3; HIPK4; INSRR; ITK; KDR; MAP2K1; MAP2K2; MAP2K5; MAP3K12; MAP3K13; MAP3K19; MAP4K1; MAP4K5; MAPK13; MAPK15; MERTK; MKNK1; MKNK2; MLTK; MST1R; MUSK; NTRK1; NTRK2; NTRK3; PDGFRA; PIP4K2C; PLK4; PTK2B; PTK6; RET; RIPK2; ROS1; SLK; SRMS; STK10; TEK; TIE1; TNK1; TYRO3; YES1",NA,"42642645",71
"foretinib","HS578T","trt_cp","up",0.480525426210249,2.25860859527209e-05,6.23466946078869e-05,0.874286489717709,0.94368949954922,22,2,"ABL2; ALK; AURKC; AXL; BLK; BTK; CDK14; CDK15; CDK19; CDK7; CHEK2; DDR1; DDR2; EPHA1; EPHA2; EPHA3; EPHA4; EPHA5; EPHA6; EPHA7; EPHA8; EPHB1; EPHB2; EPHB3; EPHB4; EPHB6; FER; FGR; FLT4; FYN; HCK; HGF; HIPK3; HIPK4; INSRR; ITK; KDR; MAP2K1; MAP2K2; MAP2K5; MAP3K12; MAP3K13; MAP3K19; MAP4K1; MAP4K5; MAPK13; MAPK15; MERTK; MKNK1; MKNK2; MLTK; MST1R; MUSK; NTRK1; NTRK2; NTRK3; PDGFRA; PIP4K2C; PLK4; PTK2B; PTK6; RET; RIPK2; ROS1; SLK; SRMS; STK10; TEK; TIE1; TNK1; TYRO3; YES1",NA,"42642645",71
"dithiothreitol","NPC","trt_cp","up",0.563664876094742,1.89740529390873e-05,6.23466946078869e-05,1.10498982461886,1.09952510262524,22,2,"AXIN1; BRD2; BRD4; CAMK2A; CAMK2D; CASP8; CHKA; DAB2; DAPK2; DAPK3; DPY30; DSP; FASN; FSCN1; FXR1; GGA1; GSTO1; GSTZ1; HACL1; HRAS; HS6ST1; HSPA2; HSPA8; ILVBL; ING4; ISPD; KPNA2; MRE11A; MSRA; MYO6; NME2; OSBPL5; OSBPL8; OTC; PER2; PER3; PHLPP2; POLH; PPIB; PPIC; PUM1; PUM2; QARS; RABEP1; REL; RELA; RP11-196G11.1; SH3PXD2A; SH3PXD2B; STAMBP; STAMBPL1; TIRAP; TNPO3; TP53; TRPM7; TYK2; VKORC1",NA,"19001",56
"dithiothreitol","NEU","trt_cp","up",0.590220694637242,1.78425727179491e-05,6.23466946078869e-05,1.09670994281034,1.09952510262524,22,2,"AXIN1; BRD2; BRD4; CAMK2A; CAMK2D; CASP8; CHKA; DAB2; DAPK2; DAPK3; DPY30; DSP; FASN; FSCN1; FXR1; GGA1; GSTO1; GSTZ1; HACL1; HRAS; HS6ST1; HSPA2; HSPA8; ILVBL; ING4; ISPD; KPNA2; MRE11A; MSRA; MYO6; NME2; OSBPL5; OSBPL8; OTC; PER2; PER3; PHLPP2; POLH; PPIB; PPIC; PUM1; PUM2; QARS; RABEP1; REL; RELA; RP11-196G11.1; SH3PXD2A; SH3PXD2B; STAMBP; STAMBPL1; TIRAP; TNPO3; TP53; TRPM7; TYK2; VKORC1",NA,"19001",56
"dithiothreitol","FIBRNPC","trt_cp","up",0.349128069398508,2.9440244984616e-05,6.45001858558835e-05,0.6917172167976,1.09952510262524,22,2,"AXIN1; BRD2; BRD4; CAMK2A; CAMK2D; CASP8; CHKA; DAB2; DAPK2; DAPK3; DPY30; DSP; FASN; FSCN1; FXR1; GGA1; GSTO1; GSTZ1; HACL1; HRAS; HS6ST1; HSPA2; HSPA8; ILVBL; ING4; ISPD; KPNA2; MRE11A; MSRA; MYO6; NME2; OSBPL5; OSBPL8; OTC; PER2; PER3; PHLPP2; POLH; PPIB; PPIC; PUM1; PUM2; QARS; RABEP1; REL; RELA; RP11-196G11.1; SH3PXD2A; SH3PXD2B; STAMBP; STAMBPL1; TIRAP; TNPO3; TP53; TRPM7; TYK2; VKORC1",NA,"19001",56
"dovitinib","PC3","trt_cp","down",-0.581581581519601,1.81907204782993e-05,6.23466946078869e-05,-1.20240278371669,-0.0347461490794524,22,2,"ABL2; ANKK1; BLK; BMP2K; BTK; CSF1R; EGFR; FGFR2; FGFR3; FGR; FLT1; FLT3; FLT4; FYN; HCK; INSR; IRAK4; KDR; KIT; LRRK2; MAP2K5; MAP3K11; MAP3K19; MAP3K2; MAP3K7; MAP4K1; MAP4K4; MAP4K5; MARK4; MAST1; MELK; MINK1; MYLK2; MYLK3; MYLK4; NR1I2; NTRK1; NTRK2; NTRK3; NUAK1; PDGFRA; PDGFRB; PHKG1; PKN1; RET; RPS6KA1; RPS6KA2; RPS6KA6; SIK2; STK4; TNIK; TYK2; TYRO3; ULK1; ULK2; YES1","EGFR inhibitor; FGFR inhibitor; FLT3 inhibitor; PDGFR receptor inhibitor; VEGFR inhibitor","9886808",55
"dovitinib","VCAP","trt_cp","down",-0.534126777775637,2.02796070404007e-05,6.23466946078869e-05,-1.11236980695828,-0.0347461490794524,22,2,"ABL2; ANKK1; BLK; BMP2K; BTK; CSF1R; EGFR; FGFR2; FGFR3; FGR; FLT1; FLT3; FLT4; FYN; HCK; INSR; IRAK4; KDR; KIT; LRRK2; MAP2K5; MAP3K11; MAP3K19; MAP3K2; MAP3K7; MAP4K1; MAP4K4; MAP4K5; MARK4; MAST1; MELK; MINK1; MYLK2; MYLK3; MYLK4; NR1I2; NTRK1; NTRK2; NTRK3; NUAK1; PDGFRA; PDGFRB; PHKG1; PKN1; RET; RPS6KA1; RPS6KA2; RPS6KA6; SIK2; STK4; TNIK; TYK2; TYRO3; ULK1; ULK2; YES1","EGFR inhibitor; FGFR inhibitor; FLT3 inhibitor; PDGFR receptor inhibitor; VEGFR inhibitor","9886808",55
"dovitinib","ASC","trt_cp","down",-0.47083853253929,2.30212706531587e-05,6.23466946078869e-05,-0.945094908675851,-0.0347461490794524,22,2,"ABL2; ANKK1; BLK; BMP2K; BTK; CSF1R; EGFR; FGFR2; FGFR3; FGR; FLT1; FLT3; FLT4; FYN; HCK; INSR; IRAK4; KDR; KIT; LRRK2; MAP2K5; MAP3K11; MAP3K19; MAP3K2; MAP3K7; MAP4K1; MAP4K4; MAP4K5; MARK4; MAST1; MELK; MINK1; MYLK2; MYLK3; MYLK4; NR1I2; NTRK1; NTRK2; NTRK3; NUAK1; PDGFRA; PDGFRB; PHKG1; PKN1; RET; RPS6KA1; RPS6KA2; RPS6KA6; SIK2; STK4; TNIK; TYK2; TYRO3; ULK1; ULK2; YES1","EGFR inhibitor; FGFR inhibitor; FLT3 inhibitor; PDGFR receptor inhibitor; VEGFR inhibitor","9886808",55
"dovitinib","SKBR3","trt_cp","down",-0.43729263030844,2.45008986346472e-05,6.23466946078869e-05,-0.86865372698631,-0.0347461490794524,22,2,"ABL2; ANKK1; BLK; BMP2K; BTK; CSF1R; EGFR; FGFR2; FGFR3; FGR; FLT1; FLT3; FLT4; FYN; HCK; INSR; IRAK4; KDR; KIT; LRRK2; MAP2K5; MAP3K11; MAP3K19; MAP3K2; MAP3K7; MAP4K1; MAP4K4; MAP4K5; MARK4; MAST1; MELK; MINK1; MYLK2; MYLK3; MYLK4; NR1I2; NTRK1; NTRK2; NTRK3; NUAK1; PDGFRA; PDGFRB; PHKG1; PKN1; RET; RPS6KA1; RPS6KA2; RPS6KA6; SIK2; STK4; TNIK; TYK2; TYRO3; ULK1; ULK2; YES1","EGFR inhibitor; FGFR inhibitor; FLT3 inhibitor; PDGFR receptor inhibitor; VEGFR inhibitor","9886808",55
"olanzapine","A549","trt_cp","down",-0.487830237920131,2.22814566624145e-05,6.23466946078869e-05,-1.02104786406489,-0.561459733586398,22,2,"ADRA1A; ADRA1B; ADRA2B; ADRA2C; ADRB1; ADRB2; ADRB3; CHRM1; CHRM4; CHRM5; CYP2C8; DRD1; DRD3; DRD4; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; HRH1; HRH2; HRH4; HTR1B; HTR1D; HTR1E; HTR1F; HTR2B; HTR3A; HTR5A; HTR6; HTR7","Dopamine receptor antagonist; Serotonin receptor antagonist","4585",40
"olanzapine","MCF7","trt_cp","down",-0.271689125848188,0.00547216473794983,0.0112027264209383,-0.556817429238131,-0.561459733586398,22,2,"ADRA1A; ADRA1B; ADRA2B; ADRA2C; ADRB1; ADRB2; ADRB3; CHRM1; CHRM4; CHRM5; CYP2C8; DRD1; DRD3; DRD4; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; HRH1; HRH2; HRH4; HTR1B; HTR1D; HTR1E; HTR1F; HTR2B; HTR3A; HTR5A; HTR6; HTR7","Dopamine receptor antagonist; Serotonin receptor antagonist","4585",40
"tozasertib","NPC","trt_cp","up",0.539000200421088,2.00620146901818e-05,6.23466946078869e-05,1.05663801700626,0.242374333837946,22,2,"ABL1; ABL2; AURKA; AURKAIP1; AURKB; AURKC; BCR; BMP2K; CDKL2; DDR1; DDR2; EPHA2; EPHB6; FLT3; INCENP; JAK2; LCK; LIMK1; MAP3K19; MAP4K1; MAP4K5; MYLK2; MYLK3; NTRK1; NTRK2; NTRK3; NUAK1; PLK4; RET; RIPK1; ROS1; SLK; SRPK1; TAOK2; TAOK3; TEK; TNK1; TPX2; YES1","Aurora kinase inhibitor; BCR-ABL kinase inhibitor; FLT3 inhibitor; JAK inhibitor","5494449",38
"tozasertib","HA1E","trt_cp","up",0.534855990563581,2.02360885703569e-05,6.23466946078869e-05,0.992681623738072,0.242374333837946,22,2,"ABL1; ABL2; AURKA; AURKAIP1; AURKB; AURKC; BCR; BMP2K; CDKL2; DDR1; DDR2; EPHA2; EPHB6; FLT3; INCENP; JAK2; LCK; LIMK1; MAP3K19; MAP4K1; MAP4K5; MYLK2; MYLK3; NTRK1; NTRK2; NTRK3; NUAK1; PLK4; RET; RIPK1; ROS1; SLK; SRPK1; TAOK2; TAOK3; TEK; TNK1; TPX2; YES1","Aurora kinase inhibitor; BCR-ABL kinase inhibitor; FLT3 inhibitor; JAK inhibitor","5494449",38
"tozasertib","HS578T","trt_cp","up",0.539743356433157,2.0018496220138e-05,6.23466946078869e-05,0.982029875434579,0.242374333837946,22,2,"ABL1; ABL2; AURKA; AURKAIP1; AURKB; AURKC; BCR; BMP2K; CDKL2; DDR1; DDR2; EPHA2; EPHB6; FLT3; INCENP; JAK2; LCK; LIMK1; MAP3K19; MAP4K1; MAP4K5; MYLK2; MYLK3; NTRK1; NTRK2; NTRK3; NUAK1; PLK4; RET; RIPK1; ROS1; SLK; SRPK1; TAOK2; TAOK3; TEK; TNK1; TPX2; YES1","Aurora kinase inhibitor; BCR-ABL kinase inhibitor; FLT3 inhibitor; JAK inhibitor","5494449",38
"tozasertib","A375","trt_cp","up",0.459062836267411,2.3543492293684e-05,6.23466946078869e-05,0.89843644612741,0.242374333837946,22,2,"ABL1; ABL2; AURKA; AURKAIP1; AURKB; AURKC; BCR; BMP2K; CDKL2; DDR1; DDR2; EPHA2; EPHB6; FLT3; INCENP; JAK2; LCK; LIMK1; MAP3K19; MAP4K1; MAP4K5; MYLK2; MYLK3; NTRK1; NTRK2; NTRK3; NUAK1; PLK4; RET; RIPK1; ROS1; SLK; SRPK1; TAOK2; TAOK3; TEK; TNK1; TPX2; YES1","Aurora kinase inhibitor; BCR-ABL kinase inhibitor; FLT3 inhibitor; JAK inhibitor","5494449",38
"tozasertib","HEPG2","trt_cp","up",0.424865686140867,2.50231202751725e-05,6.23466946078869e-05,0.792145914342875,0.242374333837946,22,2,"ABL1; ABL2; AURKA; AURKAIP1; AURKB; AURKC; BCR; BMP2K; CDKL2; DDR1; DDR2; EPHA2; EPHB6; FLT3; INCENP; JAK2; LCK; LIMK1; MAP3K19; MAP4K1; MAP4K5; MYLK2; MYLK3; NTRK1; NTRK2; NTRK3; NUAK1; PLK4; RET; RIPK1; ROS1; SLK; SRPK1; TAOK2; TAOK3; TEK; TNK1; TPX2; YES1","Aurora kinase inhibitor; BCR-ABL kinase inhibitor; FLT3 inhibitor; JAK inhibitor","5494449",38
"tozasertib","MDAMB231","trt_cp","up",0.307929977050836,0.000240221954641656,0.000499915778993431,0.621472650866526,0.242374333837946,22,2,"ABL1; ABL2; AURKA; AURKAIP1; AURKB; AURKC; BCR; BMP2K; CDKL2; DDR1; DDR2; EPHA2; EPHB6; FLT3; INCENP; JAK2; LCK; LIMK1; MAP3K19; MAP4K1; MAP4K5; MYLK2; MYLK3; NTRK1; NTRK2; NTRK3; NUAK1; PLK4; RET; RIPK1; ROS1; SLK; SRPK1; TAOK2; TAOK3; TEK; TNK1; TPX2; YES1","Aurora kinase inhibitor; BCR-ABL kinase inhibitor; FLT3 inhibitor; JAK inhibitor","5494449",38
"resveratrol","HA1E","trt_cp","down",-0.599094139964349,1.74509064875551e-05,6.23466946078869e-05,-1.26370807348401,-0.92414551736077,22,2,"AHR; AKT1; ALOX15; ALOX5; APOA1; APP; ATP5A1; ATP5B; ATP5C1; BACE1; CBR1; CLEC14A; CSNK2A1; ITGA5; ITGB3; KHSRP; MAOA; MAT2B; MTNR1A; MTNR1B; NQO2; NR1I2; NR1I3; PI4K2B; PPARA; PPARG; SCN5A; SIRT1; SIRT5; SLC2A1; SNCA; SULT1B1; TXNRD1; TXNRD2; YARS","Cytochrome P450 inhibitor; SIRT activator","445154",34
"resveratrol","PC3","trt_cp","down",-0.5804575403867,1.82777574183869e-05,6.23466946078869e-05,-1.20007886179386,-0.92414551736077,22,2,"AHR; AKT1; ALOX15; ALOX5; APOA1; APP; ATP5A1; ATP5B; ATP5C1; BACE1; CBR1; CLEC14A; CSNK2A1; ITGA5; ITGB3; KHSRP; MAOA; MAT2B; MTNR1A; MTNR1B; NQO2; NR1I2; NR1I3; PI4K2B; PPARA; PPARG; SCN5A; SIRT1; SIRT5; SLC2A1; SNCA; SULT1B1; TXNRD1; TXNRD2; YARS","Cytochrome P450 inhibitor; SIRT activator","445154",34
"resveratrol","ASC","trt_cp","down",-0.509120382483442,2.13675687914951e-05,6.23466946078869e-05,-1.02193649868291,-0.92414551736077,22,2,"AHR; AKT1; ALOX15; ALOX5; APOA1; APP; ATP5A1; ATP5B; ATP5C1; BACE1; CBR1; CLEC14A; CSNK2A1; ITGA5; ITGB3; KHSRP; MAOA; MAT2B; MTNR1A; MTNR1B; NQO2; NR1I2; NR1I3; PI4K2B; PPARA; PPARG; SCN5A; SIRT1; SIRT5; SLC2A1; SNCA; SULT1B1; TXNRD1; TXNRD2; YARS","Cytochrome P450 inhibitor; SIRT activator","445154",34
"resveratrol","NPC","trt_cp","down",-0.466564027549608,2.31953445333338e-05,6.23466946078869e-05,-0.956611690699978,-0.92414551736077,22,2,"AHR; AKT1; ALOX15; ALOX5; APOA1; APP; ATP5A1; ATP5B; ATP5C1; BACE1; CBR1; CLEC14A; CSNK2A1; ITGA5; ITGB3; KHSRP; MAOA; MAT2B; MTNR1A; MTNR1B; NQO2; NR1I2; NR1I3; PI4K2B; PPARA; PPARG; SCN5A; SIRT1; SIRT5; SLC2A1; SNCA; SULT1B1; TXNRD1; TXNRD2; YARS","Cytochrome P450 inhibitor; SIRT activator","445154",34
"resveratrol","PHH","trt_cp","down",-0.452629149447524,2.38046031139467e-05,6.23466946078869e-05,-0.93014952448974,-0.92414551736077,22,2,"AHR; AKT1; ALOX15; ALOX5; APOA1; APP; ATP5A1; ATP5B; ATP5C1; BACE1; CBR1; CLEC14A; CSNK2A1; ITGA5; ITGB3; KHSRP; MAOA; MAT2B; MTNR1A; MTNR1B; NQO2; NR1I2; NR1I3; PI4K2B; PPARA; PPARG; SCN5A; SIRT1; SIRT5; SLC2A1; SNCA; SULT1B1; TXNRD1; TXNRD2; YARS","Cytochrome P450 inhibitor; SIRT activator","445154",34
"resveratrol","VCAP","trt_cp","down",-0.436688847611611,2.45008986346472e-05,6.23466946078869e-05,-0.909446051631223,-0.92414551736077,22,2,"AHR; AKT1; ALOX15; ALOX5; APOA1; APP; ATP5A1; ATP5B; ATP5C1; BACE1; CBR1; CLEC14A; CSNK2A1; ITGA5; ITGB3; KHSRP; MAOA; MAT2B; MTNR1A; MTNR1B; NQO2; NR1I2; NR1I3; PI4K2B; PPARA; PPARG; SCN5A; SIRT1; SIRT5; SLC2A1; SNCA; SULT1B1; TXNRD1; TXNRD2; YARS","Cytochrome P450 inhibitor; SIRT activator","445154",34
"topiramate","MCF7","trt_cp","down",-0.504025018712237,2.1585161141714e-05,6.23466946078869e-05,-1.03298177398483,-0.0103298177398483,22,2,"CA1; CA12; CA3; CA4; CA7; CYP3A4; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; GRIA1; GRIK1; SCN10A; SCN11A; SCN1A; SCN3A; SCN4A; SCN5A; SCN7A; SCN8A","Carbonic anhydrase inhibitor; Glutamate receptor antagonist; Kainate receptor antagonist","5284627",30
"flufenamic-acid","PC3","trt_cp","down",-0.388173814877952,2.66333036667923e-05,6.23466946078869e-05,-0.802537924869699,0,22,2,"AKR1C3; ANO1; AR; GJA1; GJA10; GJA3; GJA4; GJA5; GJA8; GJA9; GJB1; GJB2; GJB3; GJB4; GJB5; GJB6; GJB7; GJC1; GJC2; GJC3; GJD2; GJD3; GJD4; GJE1; PANX1; PANX2; PANX3; PKD2L1; TRPC5; TRPM2; TRPM5","Chloride channel blocker","3371",30
"flufenamic-acid","MCF7","trt_cp","down",-0.372112522951367,2.73295991874928e-05,6.23466946078869e-05,-0.762631694478901,0,22,2,"AKR1C3; ANO1; AR; GJA1; GJA10; GJA3; GJA4; GJA5; GJA8; GJA9; GJB1; GJB2; GJB3; GJB4; GJB5; GJB6; GJB7; GJC1; GJC2; GJC3; GJD2; GJD3; GJD4; GJE1; PANX1; PANX2; PANX3; PKD2L1; TRPC5; TRPM2; TRPM5","Chloride channel blocker","3371",30
"pazopanib","SKBR3","trt_cp","up",0.683553034823696,1.37518365338339e-05,6.23466946078869e-05,1.42468018421565,0,22,2,"BRAF; CSF1R; CYP2B6; CYP2C8; CYP2E1; DDR1; DDR2; EPHB6; FGF1; FGFR3; FLT1; FLT4; ITK; KDR; KIT; MAP3K10; MAP3K11; MAP3K9; MAP4K5; PDGFRA; PDGFRB; RAF1; RET; ROS1; SH2B3; STK10; TAOK1; TAOK2; TAOK3","KIT inhibitor; PDGFR receptor inhibitor; VEGFR inhibitor","11525740",28
"beta-alanine","NPC","trt_cp","down",-0.535671430035641,2.01925701003131e-05,6.23466946078869e-05,-1.09830488869309,-0.373423662155649,22,2,"ABAT; AGXT2; ALDH1A3; ALDH1B1; ALDH3A1; ALDH3A2; ALDH3B2; ALDH7A1; ALDH9A1; ATP5A1; ATP5B; ATP5C1; B2M; CARNS1; CNDP1; CNDP2; DPYS; GAD1; GAD2; GLRA1; GLRA2; GLRA3; GLRB; IGLL5; RP11-162P23.2; SLC6A12; SLC6A14; SLC6A6; UPB1",NA,"32334",28
"pazopanib","HS578T","trt_cp","up",0.515525693581628,2.10629395011887e-05,6.23466946078869e-05,0.937967325798828,0,22,2,"BRAF; CSF1R; CYP2B6; CYP2C8; CYP2E1; DDR1; DDR2; EPHB6; FGF1; FGFR3; FLT1; FLT4; ITK; KDR; KIT; MAP3K10; MAP3K11; MAP3K9; MAP4K5; PDGFRA; PDGFRB; RAF1; RET; ROS1; SH2B3; STK10; TAOK1; TAOK2; TAOK3","KIT inhibitor; PDGFR receptor inhibitor; VEGFR inhibitor","11525740",28
"pazopanib","PC3","trt_cp","up",0.44306624196912,2.42397878143845e-05,6.23466946078869e-05,0.899357848095149,0,22,2,"BRAF; CSF1R; CYP2B6; CYP2C8; CYP2E1; DDR1; DDR2; EPHB6; FGF1; FGFR3; FLT1; FLT4; ITK; KDR; KIT; MAP3K10; MAP3K11; MAP3K9; MAP4K5; PDGFRA; PDGFRB; RAF1; RET; ROS1; SH2B3; STK10; TAOK1; TAOK2; TAOK3","KIT inhibitor; PDGFR receptor inhibitor; VEGFR inhibitor","11525740",28
"emetine","MCF7","trt_cp","up",0.680380012615713,1.3925910414009e-05,6.23466946078869e-05,1.34876826925318,1.09254260867909,22,2,"MRPS7; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPSA; RPSAP58; RSRC1","Protein synthesis inhibitor","10219",27
"emetine","PC3","trt_cp","up",0.655530380598132,1.49703536950597e-05,6.23466946078869e-05,1.33062810164811,1.09254260867909,22,2,"MRPS7; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPSA; RPSAP58; RSRC1","Protein synthesis inhibitor","10219",27
"emetine","A549","trt_cp","up",0.679577522011192,1.3925910414009e-05,6.23466946078869e-05,1.32653356051568,1.09254260867909,22,2,"MRPS7; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPSA; RPSAP58; RSRC1","Protein synthesis inhibitor","10219",27
"emetine","A375","trt_cp","up",0.624356714920575,1.63629447364606e-05,6.23466946078869e-05,1.22193474128728,1.09254260867909,22,2,"MRPS7; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPSA; RPSAP58; RSRC1","Protein synthesis inhibitor","10219",27
"emetine","HA1E","trt_cp","up",0.585756153239397,1.80166465981242e-05,6.23466946078869e-05,1.08715126982041,1.09254260867909,22,2,"MRPS7; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPSA; RPSAP58; RSRC1","Protein synthesis inhibitor","10219",27
"emetine","HCC515","trt_cp","up",0.488561707060651,2.22379381923707e-05,6.23466946078869e-05,0.981701401670627,1.09254260867909,22,2,"MRPS7; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPSA; RPSAP58; RSRC1","Protein synthesis inhibitor","10219",27
"emetine","PHH","trt_cp","up",0.450968557767337,2.38916400540343e-05,6.23466946078869e-05,0.940549032877484,1.09254260867909,22,2,"MRPS7; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPSA; RPSAP58; RSRC1","Protein synthesis inhibitor","10219",27
"emetine","SKB","trt_cp","up",0.45850837763841,2.3543492293684e-05,6.23466946078869e-05,0.911725249247617,1.09254260867909,22,2,"MRPS7; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPSA; RPSAP58; RSRC1","Protein synthesis inhibitor","10219",27
"emetine","NPC","trt_cp","up",0.458688380669811,2.3543492293684e-05,6.23466946078869e-05,0.899197404001187,1.09254260867909,22,2,"MRPS7; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPSA; RPSAP58; RSRC1","Protein synthesis inhibitor","10219",27
"emetine","HT29","trt_cp","up",0.423468881314534,2.51101572152601e-05,6.23466946078869e-05,0.872025062654151,1.09254260867909,22,2,"MRPS7; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPSA; RPSAP58; RSRC1","Protein synthesis inhibitor","10219",27
"emetine","ASC","trt_cp","up",0.349125152781165,2.9440244984616e-05,6.45001858558835e-05,0.737176111255569,1.09254260867909,22,2,"MRPS7; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPSA; RPSAP58; RSRC1","Protein synthesis inhibitor","10219",27
"aspirin","PC3","trt_cp","up",0.531004539955458,2.0410162450532e-05,6.23466946078869e-05,1.07785936987811,0.366472185758556,22,2,"AKR1C1; ASIC3; CRP; EDNRA; EPX; HSPA5; IKBKB; LPO; LTF; MPO; NFKB1; NFKB2; NFKBIA; PRKAA1; PRKAA2; PRKAB1; PRKAB2; PRKAG1; PRKAG2; PRKAG3; PTGIR; RPS6KA3; SELP; SERPINC1; TF; TP53","Cyclooxygenase inhibitor","2244",25
"trimebutine","VCAP","trt_cp","down",-0.564218245931642,1.89740529390873e-05,6.23466946078869e-05,-1.1750381509106,-0.011750381509106,22,2,"CACNA1C; CACNA1D; CACNA1F; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4; CHRM1; CHRM4; KCNMA1; KCNMB1; KCNMB2; KCNMB3; KCNMB4; KCNN1; KCNN2; KCNN3; KCNN4; OPRM1","Opioid receptor agonist","5388977",22
"acamprosate","PC3","trt_cp","down",-0.563438308606207,1.90175714091311e-05,6.23466946078869e-05,-1.16489210155273,-0.957686510716801,22,2,"GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B; GRM5","Glutamate receptor antagonist","73707392",22
"acamprosate","NPC","trt_cp","down",-0.538946842652241,2.00620146901818e-05,6.23466946078869e-05,-1.10502057574972,-0.957686510716801,22,2,"GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B; GRM5","Glutamate receptor antagonist","73707392",22
"acamprosate","A549","trt_cp","down",-0.456121243866463,2.36740477038154e-05,6.23466946078869e-05,-0.954679693063068,-0.957686510716801,22,2,"GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B; GRM5","Glutamate receptor antagonist","73707392",22
"cytarabine","PC3","trt_cp","up",0.36304723523903,2.77647838879305e-05,6.23466946078869e-05,0.73693129675229,0.00736931296752307,22,2,"AICDA; BCR; CDA; DCK; NT5C; NT5C1A; NT5C1B-RDH14; NT5C2; NT5C3A; NT5C3B; NT5E; NT5M; POLA1; POLB; SLC28A1; SLC28A3; SLC29A1; SLC29A2; SLC29A3; ST6GAL1; UCK1; UCK2; UCKL1","Ribonucleotide reductase inhibitor","596",22
"mibefradil","NPC","trt_cp","up",0.590111404868913,1.78425727179491e-05,6.23466946078869e-05,1.15683471762411,0,22,2,"ANO1; CACNA1C; CACNA1D; CACNA1F; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4; CATSPER1; CATSPER2; CATSPER3; CATSPER4; CYP3A5; CYP3A7; SCN2A; SCN4A; SCN5A; SCN9A","T-type calcium channel blocker","5230270",21
"LY-294002","HT29","trt_cp","up",0.599671323747601,1.74073880175113e-05,6.23466946078869e-05,1.2348685977577,1.08483529761654,22,2,"AKT1; CHEK1; GSK3B; LCK; MAPK11; MAPK12; MAPK14; MAPK8; MTOR; PDE2A; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIM1; PLK1; PRKCA; PRKDC; ROCK1; RPS6KB1; SGK1","DNA dependent protein kinase inhibitor; MTOR inhibitor; Phosphodiesterase inhibitor; PI3K inhibitor; PLK inhibitor","3973",20
"LY-294002","NEU","trt_cp","up",0.618083651744533,1.66240555567233e-05,6.23466946078869e-05,1.1484830886409,1.08483529761654,22,2,"AKT1; CHEK1; GSK3B; LCK; MAPK11; MAPK12; MAPK14; MAPK8; MTOR; PDE2A; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIM1; PLK1; PRKCA; PRKDC; ROCK1; RPS6KB1; SGK1","DNA dependent protein kinase inhibitor; MTOR inhibitor; Phosphodiesterase inhibitor; PI3K inhibitor; PLK inhibitor","3973",20
"LY-294002","HA1E","trt_cp","up",0.614947356970406,1.67546109668546e-05,6.23466946078869e-05,1.14132953841947,1.08483529761654,22,2,"AKT1; CHEK1; GSK3B; LCK; MAPK11; MAPK12; MAPK14; MAPK8; MTOR; PDE2A; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIM1; PLK1; PRKCA; PRKDC; ROCK1; RPS6KB1; SGK1","DNA dependent protein kinase inhibitor; MTOR inhibitor; Phosphodiesterase inhibitor; PI3K inhibitor; PLK inhibitor","3973",20
"LY-294002","VCAP","trt_cp","up",0.544553957983864,1.98009038699191e-05,6.23466946078869e-05,1.11054940704327,1.08483529761654,22,2,"AKT1; CHEK1; GSK3B; LCK; MAPK11; MAPK12; MAPK14; MAPK8; MTOR; PDE2A; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIM1; PLK1; PRKCA; PRKDC; ROCK1; RPS6KB1; SGK1","DNA dependent protein kinase inhibitor; MTOR inhibitor; Phosphodiesterase inhibitor; PI3K inhibitor; PLK inhibitor","3973",20
"LY-294002","NKDBA","trt_cp","up",0.539071268137074,2.00620146901818e-05,6.23466946078869e-05,1.02483570895417,1.08483529761654,22,2,"AKT1; CHEK1; GSK3B; LCK; MAPK11; MAPK12; MAPK14; MAPK8; MTOR; PDE2A; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIM1; PLK1; PRKCA; PRKDC; ROCK1; RPS6KB1; SGK1","DNA dependent protein kinase inhibitor; MTOR inhibitor; Phosphodiesterase inhibitor; PI3K inhibitor; PLK inhibitor","3973",20
"spermidine","FIBRNPC","trt_cp","down",-0.468315209772326,2.315182606329e-05,6.23466946078869e-05,-0.982448054926063,-0.334032338674861,22,2,"ACTA1; ACTA2; ACTC1; ADRB1; ADRB2; AMD1; AOC3; DHPS; DOHH; EIF5A; EIF5A2; ODC1; PAOX; SAT1; SAT2; SLC22A1; SMOX; SMS; SRM; TXNRD1; WIF1",NA,"16219989",20
"LY-294002","NPC","trt_cp","up",0.500466391822997,2.17592350218891e-05,6.23466946078869e-05,0.98109762375042,1.08483529761654,22,2,"AKT1; CHEK1; GSK3B; LCK; MAPK11; MAPK12; MAPK14; MAPK8; MTOR; PDE2A; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIM1; PLK1; PRKCA; PRKDC; ROCK1; RPS6KB1; SGK1","DNA dependent protein kinase inhibitor; MTOR inhibitor; Phosphodiesterase inhibitor; PI3K inhibitor; PLK inhibitor","3973",20
"LY-294002","MCF7","trt_cp","up",0.466733571447547,2.31953445333338e-05,6.23466946078869e-05,0.9252409237354,1.08483529761654,22,2,"AKT1; CHEK1; GSK3B; LCK; MAPK11; MAPK12; MAPK14; MAPK8; MTOR; PDE2A; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIM1; PLK1; PRKCA; PRKDC; ROCK1; RPS6KB1; SGK1","DNA dependent protein kinase inhibitor; MTOR inhibitor; Phosphodiesterase inhibitor; PI3K inhibitor; PLK inhibitor","3973",20
"LY-294002","FIBRNPC","trt_cp","up",0.405218483658568,2.58934896760481e-05,6.23466946078869e-05,0.802847511499591,1.08483529761654,22,2,"AKT1; CHEK1; GSK3B; LCK; MAPK11; MAPK12; MAPK14; MAPK8; MTOR; PDE2A; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIM1; PLK1; PRKCA; PRKDC; ROCK1; RPS6KB1; SGK1","DNA dependent protein kinase inhibitor; MTOR inhibitor; Phosphodiesterase inhibitor; PI3K inhibitor; PLK inhibitor","3973",20
"propofol","SKB","trt_cp","down",-0.552546817114903,1.94527561095689e-05,6.23466946078869e-05,-1.18953762080102,-0.858534806979141,22,2,"CYP2B6; FAAH; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; SCN2A; SCN4A; TRPV1","GABA receptor agonist","4943",19
"propofol","PHH","trt_cp","down",-0.577954537882747,1.83647943584744e-05,6.23466946078869e-05,-1.18769226251667,-0.858534806979141,22,2,"CYP2B6; FAAH; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; SCN2A; SCN4A; TRPV1","GABA receptor agonist","4943",19
"propofol","MCF7","trt_cp","down",-0.522953784041753,2.07583102108822e-05,6.23466946078869e-05,-1.07177562124142,-0.858534806979141,22,2,"CYP2B6; FAAH; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; SCN2A; SCN4A; TRPV1","GABA receptor agonist","4943",19
"tetrahydrobiopterin","VCAP","trt_cp","down",-0.508838763684745,2.13675687914951e-05,6.23466946078869e-05,-1.05970511287612,-1.01809436635178,22,2,"CAV1; DBH; DDC; DNM2; LYPLA1; NOS3; NOSIP; NOSTRIN; PAH; PCBD1; PRKG2; PTS; QDPR; SPR; TAT; TH; TPH1; TPH2; WASL; ZDHHC21","Nitric oxide stimulant; Nitric oxide synthase stimulant; Phenylalanine 4-hydroxylase stimulant","53484654",19
"tetrahydrobiopterin","MCF7","trt_cp","down",-0.486301738800856,2.2368493602502e-05,6.23466946078869e-05,-0.996658527233179,-1.01809436635178,22,2,"CAV1; DBH; DDC; DNM2; LYPLA1; NOS3; NOSIP; NOSTRIN; PAH; PCBD1; PRKG2; PTS; QDPR; SPR; TAT; TH; TPH1; TPH2; WASL; ZDHHC21","Nitric oxide stimulant; Nitric oxide synthase stimulant; Phenylalanine 4-hydroxylase stimulant","53484654",19
"propofol","ASC","trt_cp","down",-0.424429386636464,2.50666387452163e-05,6.23466946078869e-05,-0.85193973024938,-0.858534806979141,22,2,"CYP2B6; FAAH; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; SCN2A; SCN4A; TRPV1","GABA receptor agonist","4943",19
"propofol","NPC","trt_cp","down",-0.41511286840853,2.54583049756103e-05,6.23466946078869e-05,-0.851119673681614,-0.858534806979141,22,2,"CYP2B6; FAAH; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; SCN2A; SCN4A; TRPV1","GABA receptor agonist","4943",19
"stiripentol","A549","trt_cp","down",-0.346157282467199,3.01582997403383e-05,6.57286741376738e-05,-0.724520799285731,-0.00724520799285732,22,2,"ABAT; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; LDHA; LDHB; SCN1A; SCN3A","GABA uptake inhibitor","5311454",19
"nortriptyline","ASC","trt_cp","down",-0.578205485697834,1.83647943584744e-05,6.23466946078869e-05,-1.16060819779203,0,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; ADRB1; ADRB2; ADRB3; CHRM1; CHRM4; CHRM5; HRH1; HTR6; KCNJ10; PGRMC1; PIK3CD; SIGMAR1; SLC6A2; SLC6A4","Tricyclic antidepressant","441358",18
"tiapride","MCF7","trt_cp","down",-0.545803859698871,1.97573853998753e-05,6.23466946078869e-05,-1.11860605785007,-0.749466058759549,22,2,"ADRA1B; ADRA1D; ADRA2B; ADRA2C; DRD3; HTR1B; HTR1D; HTR1E; HTR1F; HTR2B; HTR3A; HTR3B; HTR3C; HTR3D; HTR3E; HTR4; HTR6; HTR7; SCN10A",NA,"5702214",18
"nitrazepam","A549","trt_cp","down",-0.458514580973029,2.3543492293684e-05,6.23466946078869e-05,-0.959689041706698,-0.911475980433373,22,2,"GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; GABRR1; GABRR2; GABRR3; SCN1A","Benzodiazepine receptor agonist","4506",18
"nitrazepam","PC3","trt_cp","down",-0.440629728076418,2.43268247544721e-05,6.23466946078869e-05,-0.91098897981445,-0.911475980433373,22,2,"GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; GABRR1; GABRR2; GABRR3; SCN1A","Benzodiazepine receptor agonist","4506",18
"docetaxel","VCAP","trt_cp","down",-0.346463540622556,3.01582997403383e-05,6.57286741376738e-05,-0.721543269943081,0,22,2,"ABCB1; ABCG2; BCL2; GHRHR; KIF1A; KIF1B; KIF1C; KLK3; MAP2; MAP4; MAPT; NDC80; NR1I2; TUBA1A; TUBA1B; TUBA1C; TUBB; TUBB1; TYMP","Tubulin inhibitor","73707494",18
"galantamine","MCF7","trt_cp","down",-0.661509429369271,1.47092428747971e-05,6.23466946078869e-05,-1.35574060510614,-0.753073109209816,22,2,"ACHE; BCHE; CHRNA1; CHRNA10; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNA9; CHRNB1; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; CHRNG","Acetylcholinesterase inhibitor","9651",17
"ziprasidone","NEU","trt_cp","down",-0.592706938117989,1.77120173078178e-05,6.23466946078869e-05,-1.18287604913343,-0.362857107951347,22,2,"ADRA1A; ADRA1B; ADRA2B; ADRA2C; CHRM1; CHRM4; CHRM5; DRD1; DRD3; DRD4; HRH1; HTR1B; HTR1D; HTR1E; HTR3A; HTR6; HTR7; SLC6A4","Dopamine receptor antagonist; Serotonin receptor antagonist","60854",17
"ziprasidone","PHH","trt_cp","down",-0.552717281127879,1.94527561095689e-05,6.23466946078869e-05,-1.13582988821175,-0.362857107951347,22,2,"ADRA1A; ADRA1B; ADRA2B; ADRA2C; CHRM1; CHRM4; CHRM5; DRD1; DRD3; DRD4; HRH1; HTR1B; HTR1D; HTR1E; HTR3A; HTR6; HTR7; SLC6A4","Dopamine receptor antagonist; Serotonin receptor antagonist","60854",17
"ponatinib","BT20","trt_cp","up",0.519737101067527,2.08888656210136e-05,6.23466946078869e-05,1.04636155297682,0.967023843201954,22,2,"ABL1; ABL2; BCR; DDR1; FGFR2; FGFR3; FGFR4; FLT3; KDR; KIT; LCK; LYN; PDGFRA; RET; RIPK2; SRC; TEK; YES1",NA,"24826799",17
"ponatinib","MCF7","trt_cp","up",0.527025130624052,2.05842363307071e-05,6.23466946078869e-05,1.0447613981956,0.967023843201954,22,2,"ABL1; ABL2; BCR; DDR1; FGFR2; FGFR3; FGFR4; FLT3; KDR; KIT; LCK; LYN; PDGFRA; RET; RIPK2; SRC; TEK; YES1",NA,"24826799",17
"ziprasidone","ASC","trt_cp","down",-0.50214565360611,2.16721980818016e-05,6.23466946078869e-05,-1.00793641097597,-0.362857107951347,22,2,"ADRA1A; ADRA1B; ADRA2B; ADRA2C; CHRM1; CHRM4; CHRM5; DRD1; DRD3; DRD4; HRH1; HTR1B; HTR1D; HTR1E; HTR3A; HTR6; HTR7; SLC6A4","Dopamine receptor antagonist; Serotonin receptor antagonist","60854",17
"ponatinib","MCF10A","trt_cp","up",0.45357395656643,2.37610846439029e-05,6.23466946078869e-05,0.925165159743835,0.967023843201954,22,2,"ABL1; ABL2; BCR; DDR1; FGFR2; FGFR3; FGFR4; FLT3; KDR; KIT; LCK; LYN; PDGFRA; RET; RIPK2; SRC; TEK; YES1",NA,"24826799",17
"ponatinib","HS578T","trt_cp","up",0.454416523691258,2.37610846439029e-05,6.23466946078869e-05,0.826782945703946,0.967023843201954,22,2,"ABL1; ABL2; BCR; DDR1; FGFR2; FGFR3; FGFR4; FLT3; KDR; KIT; LCK; LYN; PDGFRA; RET; RIPK2; SRC; TEK; YES1",NA,"24826799",17
"galantamine","A375","trt_cp","down",-0.395109312973654,2.63286743764859e-05,6.23466946078869e-05,-0.815876821009483,-0.753073109209816,22,2,"ACHE; BCHE; CHRNA1; CHRNA10; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNA9; CHRNB1; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; CHRNG","Acetylcholinesterase inhibitor","9651",17
"galantamine","PC3","trt_cp","down",-0.363628592493725,2.77212654178868e-05,6.23466946078869e-05,-0.751791400805741,-0.753073109209816,22,2,"ACHE; BCHE; CHRNA1; CHRNA10; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNA9; CHRNB1; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; CHRNG","Acetylcholinesterase inhibitor","9651",17
"menadione","A375","trt_cp","up",0.675282087424535,1.41435027642279e-05,6.23466946078869e-05,1.32160129469898,0.0379725652135444,22,2,"AOX1; BGLAP; CDC25A; F10; F2; F7; F9; GGCX; NQO1; NQO2; PKM; PROC; PROS1; PROZ; RP11-196G11.1; VKORC1; VKORC1L1","Mitochondrial DNA polymerase inhibitor; Phosphatase inhibitor","4055",16
"menadione","NPC","trt_cp","up",0.600044636789473,1.74073880175113e-05,6.23466946078869e-05,1.17630749420342,0.0379725652135444,22,2,"AOX1; BGLAP; CDC25A; F10; F2; F7; F9; GGCX; NQO1; NQO2; PKM; PROC; PROS1; PROZ; RP11-196G11.1; VKORC1; VKORC1L1","Mitochondrial DNA polymerase inhibitor; Phosphatase inhibitor","4055",16
"menadione","ASC","trt_cp","up",0.555062223661667,1.93657191694813e-05,6.23466946078869e-05,1.17201126382393,0.0379725652135444,22,2,"AOX1; BGLAP; CDC25A; F10; F2; F7; F9; GGCX; NQO1; NQO2; PKM; PROC; PROS1; PROZ; RP11-196G11.1; VKORC1; VKORC1L1","Mitochondrial DNA polymerase inhibitor; Phosphatase inhibitor","4055",16
"streptozotocin","PC3","trt_cp","down",-0.555606074738427,1.93222006994376e-05,6.23466946078869e-05,-1.14869918880482,-0.905775108533068,22,2,"ACMSD; CAT; G6PC; IGF1; IGF2; IGFBP1; IGFBP2; LPL; MGEA5; MGMT; OGT; PRKCB; SLC2A1; SLC2A2; SLC2A4; SORD; UCP3","DNA alkylating agent","73707368",16
"bromocriptine","HCC515","trt_cp","up",0.48205795296185,2.25425674826771e-05,6.23466946078869e-05,0.968632951109231,0.0247539580640685,22,2,"ADCY10; ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; DRD1; DRD3; DRD4; GH1; HTR1B; HTR1D; HTR2B; HTR6; HTR7; PRL; PRLR","Dopamine receptor agonist","31101",16
"procaine","A375","trt_cp","down",-0.461306300461163,2.34564553535965e-05,6.23466946078869e-05,-0.952569594220107,-0.00952569594220107,22,2,"CHRNA10; CHRNA2; GRIN3A; HTR3A; KCNMA1; KCNMB1; KCNMB2; KCNMB3; KCNMB4; KCNN1; KCNN2; KCNN3; KCNN4; MAOA; MAOB; SCN10A; SLC6A3",NA,"5795",16
"menadione","HA1E","trt_cp","up",0.51148962305383,2.12805318514076e-05,6.23466946078869e-05,0.949314130338587,0.0379725652135444,22,2,"AOX1; BGLAP; CDC25A; F10; F2; F7; F9; GGCX; NQO1; NQO2; PKM; PROC; PROS1; PROZ; RP11-196G11.1; VKORC1; VKORC1L1","Mitochondrial DNA polymerase inhibitor; Phosphatase inhibitor","4055",16
"bromocriptine","A549","trt_cp","up",0.460342043384191,2.34999738236403e-05,6.23466946078869e-05,0.898586474811977,0.0247539580640685,22,2,"ADCY10; ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; DRD1; DRD3; DRD4; GH1; HTR1B; HTR1D; HTR2B; HTR6; HTR7; PRL; PRLR","Dopamine receptor agonist","31101",16
"paracetamol","PC3","trt_cp","down",-0.395935533806424,2.62851559064421e-05,6.23466946078869e-05,-0.818585050058286,-0.548451983539052,22,2,"BAZ2B; BPNT1; CREBBP; CYP2E1; EPX; GPER1; GSS; INS-IGF2; LPO; LTF; MIF; MPO; NR1I3; SULT1A1; TF; UGT1A1; UGT1A6",NA,"1983",16
"streptozotocin","MCF7","trt_cp","down",-0.380895646163037,2.69379329570988e-05,6.23466946078869e-05,-0.780632400514286,-0.905775108533068,22,2,"ACMSD; CAT; G6PC; IGF1; IGF2; IGFBP1; IGFBP2; LPL; MGEA5; MGMT; OGT; PRKCB; SLC2A1; SLC2A2; SLC2A4; SORD; UCP3","DNA alkylating agent","73707368",16
"bromocriptine","NEU","trt_cp","up",0.36381489114709,2.77212654178868e-05,6.23466946078869e-05,0.67601731367401,0.0247539580640685,22,2,"ADCY10; ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; DRD1; DRD3; DRD4; GH1; HTR1B; HTR1D; HTR2B; HTR6; HTR7; PRL; PRLR","Dopamine receptor agonist","31101",16
"bromocriptine","PC3","trt_cp","up",0.304874283260478,0.000316770943448662,0.000657610583056725,0.618848951601699,0.0247539580640685,22,2,"ADCY10; ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; DRD1; DRD3; DRD4; GH1; HTR1B; HTR1D; HTR2B; HTR6; HTR7; PRL; PRLR","Dopamine receptor agonist","31101",16
"methotrexate","HA1E","trt_cp","up",0.645729621246866,1.54055383954975e-05,6.23466946078869e-05,1.19846078238682,0.909835660442775,22,2,"ABCB1; ABCC2; ABCC3; ABCC4; ABCG2; AOX1; CRP; DHFR; FOLR1; FOLR2; FPGS; GGH; PDF; SLC19A1; SLC22A6; TYMS","Dihydrofolate reductase inhibitor","4112",15
"trimipramine","PC3","trt_cp","down",-0.540416729502147,2.0018496220138e-05,6.23466946078869e-05,-1.11729566507696,-0.0203009940251972,22,2,"ADRA1A; ADRA1B; ADRA2B; ADRB1; ADRB2; ADRB3; CHRM1; CHRM4; CHRM5; DRD1; HRH1; HTR1D; HTR3A; SLC6A2; SLC6A3; SLC6A4","Norepinephrine reuptake inhibitor; Tricyclic antidepressant","5584",15
"methotrexate","PC3","trt_cp","up",0.494190882924176,2.20203458421518e-05,6.23466946078869e-05,1.00313318171035,0.909835660442775,22,2,"ABCB1; ABCC2; ABCC3; ABCC4; ABCG2; AOX1; CRP; DHFR; FOLR1; FOLR2; FPGS; GGH; PDF; SLC19A1; SLC22A6; TYMS","Dihydrofolate reductase inhibitor","4112",15
"trimipramine","ASC","trt_cp","down",-0.459847450626954,2.34999738236403e-05,6.23466946078869e-05,-0.923032959964546,-0.0203009940251972,22,2,"ADRA1A; ADRA1B; ADRA2B; ADRB1; ADRB2; ADRB3; CHRM1; CHRM4; CHRM5; DRD1; HRH1; HTR1D; HTR3A; SLC6A2; SLC6A3; SLC6A4","Norepinephrine reuptake inhibitor; Tricyclic antidepressant","5584",15
"miconazole","PC3","trt_cp","up",0.429591511268201,2.48055279249536e-05,6.23466946078869e-05,0.872006170944164,0.58424413453259,22,2,"CYP51A1; KCNH2; KCNH6; KCNH7; KCNMA1; KCNMB1; KCNMB2; KCNMB3; KCNMB4; KCNN1; KCNN2; KCNN3; KCNN4; NOS2; NOS3; NR1I2",NA,"4189",15
"methotrexate","MCF7","trt_cp","up",0.433620566610304,2.46314540447785e-05,6.23466946078869e-05,0.859598533606391,0.909835660442775,22,2,"ABCB1; ABCC2; ABCC3; ABCC4; ABCG2; AOX1; CRP; DHFR; FOLR1; FOLR2; FPGS; GGH; PDF; SLC19A1; SLC22A6; TYMS","Dihydrofolate reductase inhibitor","4112",15
"lorazepam","MCF7","trt_cp","down",-0.387352222026363,2.66768221368361e-05,6.23466946078869e-05,-0.793864928546735,-0.00793864928546736,22,2,"GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; TSPO","Benzodiazepine receptor agonist","3958",15
"trimipramine","A549","trt_cp","down",-0.323309647336237,7.19577902173874e-05,0.000151706221085891,-0.67669980083991,-0.0203009940251972,22,2,"ADRA1A; ADRA1B; ADRA2B; ADRB1; ADRB2; ADRB3; CHRM1; CHRM4; CHRM5; DRD1; HRH1; HTR1D; HTR3A; SLC6A2; SLC6A3; SLC6A4","Norepinephrine reuptake inhibitor; Tricyclic antidepressant","5584",15
"chlordiazepoxide","A549","trt_cp","up",0.326945991307458,5.60082709463426e-05,0.000118575395015899,0.638197727114155,0.00638197727114169,22,2,"GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ; TRHR","Benzodiazepine receptor agonist","2712",15
"sulfasalazine","MCF7","trt_cp","down",-0.637658150412747,1.57536861558477e-05,6.23466946078869e-05,-1.30685823710134,-0.998780040908746,22,2,"ACAT1; ALOX5; CHUK; CRP; IKBKB; MPO; NAT2; NFKB2; NFKBIA; PLA2G1B; PPARG; SLC46A1; SLC7A11; TBXAS1; TNF","Antirheumatic; NFkB pathway inhibitor","5359476",14
"sulfasalazine","VCAP","trt_cp","down",-0.478090120742025,2.27166413628523e-05,6.23466946078869e-05,-0.995668139937103,-0.998780040908746,22,2,"ACAT1; ALOX5; CHUK; CRP; IKBKB; MPO; NAT2; NFKB2; NFKBIA; PLA2G1B; PPARG; SLC46A1; SLC7A11; TBXAS1; TNF","Antirheumatic; NFkB pathway inhibitor","5359476",14
"gabapentin","PC3","trt_cp","down",-0.472785675523943,2.29342337130712e-05,6.23466946078869e-05,-0.977470453699724,-0.654905203978815,22,2,"ADORA1; BCAT1; BCAT2; CACNA1B; CACNA2D1; CACNA2D2; GABBR1; GABBR2; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B",NA,"3446",14
"sulfasalazine","A549","trt_cp","down",-0.389697141956625,2.65462667267047e-05,6.23466946078869e-05,-0.815651436703582,-0.998780040908746,22,2,"ACAT1; ALOX5; CHUK; CRP; IKBKB; MPO; NAT2; NFKB2; NFKBIA; PLA2G1B; PPARG; SLC46A1; SLC7A11; TBXAS1; TNF","Antirheumatic; NFkB pathway inhibitor","5359476",14
"asenapine","PC3","trt_cp","down",-0.572234564940562,1.86259051787371e-05,6.23466946078869e-05,-1.18307810234574,-0.792662328571646,22,2,"ADRA2B; ADRA2C; ADRB1; ADRB2; DRD1; DRD3; DRD4; HRH2; HTR1B; HTR1E; HTR2B; HTR5A; HTR6; HTR7",NA,"6440510",13
"apomorphine","MCF7","trt_cp","up",0.513515477602288,2.11499764412762e-05,6.23466946078869e-05,1.01798020094332,0.682046734632022,22,2,"ADCY10; ADRA2B; ADRA2C; CALY; COMT; DDC; DRD1; DRD3; DRD4; GAD1; HTR1B; HTR1D; HTR2B; TH",NA,"73707506",13
"danazol","PHH","trt_cp","up",0.431810273120182,2.47184909848661e-05,6.23466946078869e-05,0.900592131700862,0.451356032873375,22,2,"AR; CCL2; CYP2C8; ESR1; GNRHR; GNRHR2; PGR; PLG; PROS1; SERPINA6; SERPINC1; SERPING1; SHBG; TNF","Estrogen receptor antagonist; Progesterone receptor agonist","28417",13
"danazol","MCF7","trt_cp","up",0.432692441390513,2.46749725148223e-05,6.23466946078869e-05,0.857758641453275,0.451356032873375,22,2,"AR; CCL2; CYP2C8; ESR1; GNRHR; GNRHR2; PGR; PLG; PROS1; SERPINA6; SERPINC1; SERPING1; SHBG; TNF","Estrogen receptor antagonist; Progesterone receptor agonist","28417",13
"danazol","NEU","trt_cp","up",0.443737432879608,2.41962693443407e-05,6.23466946078869e-05,0.82452421451489,0.451356032873375,22,2,"AR; CCL2; CYP2C8; ESR1; GNRHR; GNRHR2; PGR; PLG; PROS1; SERPINA6; SERPINC1; SERPING1; SHBG; TNF","Estrogen receptor antagonist; Progesterone receptor agonist","28417",13
"danazol","A549","trt_cp","up",0.330325404384525,4.80226316933093e-05,0.000101979024171606,0.64479433267625,0.451356032873375,22,2,"AR; CCL2; CYP2C8; ESR1; GNRHR; GNRHR2; PGR; PLG; PROS1; SERPINA6; SERPINC1; SERPING1; SHBG; TNF","Estrogen receptor antagonist; Progesterone receptor agonist","28417",13
"dorsomorphin","VCAP","trt_cp","up",0.632455639501932,1.60147969761104e-05,6.23466946078869e-05,1.28981384697025,0.954913213059214,22,2,"ACVR1; BMPR1A; BMPR1B; EPHA2; FKBP1A; FLT1; FLT3; KDR; LCK; MKNK1; PRKAA1; RPS6KA1; SRC","AMPK inhibitor","11524144",12
"epibatidine","VCAP","trt_cp","down",-0.608219997096387,1.70592402571611e-05,6.23466946078869e-05,-1.26667598201277,-0.642313779743591,22,2,"CHRNA1; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; STXBP5","Acetylcholine receptor agonist","1204",12
"dorsomorphin","A549","trt_cp","up",0.613002762024747,1.68416479069422e-05,6.23466946078869e-05,1.19657980168044,0.954913213059214,22,2,"ACVR1; BMPR1A; BMPR1B; EPHA2; FKBP1A; FLT1; FLT3; KDR; LCK; MKNK1; PRKAA1; RPS6KA1; SRC","AMPK inhibitor","11524144",12
"dorsomorphin","HA1E","trt_cp","up",0.641206953447452,1.56231307457164e-05,6.23466946078869e-05,1.19006680476676,0.954913213059214,22,2,"ACVR1; BMPR1A; BMPR1B; EPHA2; FKBP1A; FLT1; FLT3; KDR; LCK; MKNK1; PRKAA1; RPS6KA1; SRC","AMPK inhibitor","11524144",12
"cladribine","VCAP","trt_cp","up",0.549215284277083,1.9626829989744e-05,6.23466946078869e-05,1.1200555966046,1.06110454307986,22,2,"ADA; APAF1; DCK; DGUOK; PNP; POLA1; POLE; POLE2; POLE3; POLE4; RRM1; RRM2; RRM2B","Adenosine deaminase inhibitor; Ribonucleoside reductase inhibitor","20279",12
"levodopa","PC3","trt_cp","up",0.544283556164981,1.98444223399629e-05,6.23466946078869e-05,1.10481377604081,0.740225229947341,22,2,"COMT; DDC; DRD1; DRD3; DRD4; FARS2; FOSB; GAD1; PAH; PDYN; SLC7A8; TH; TYR",NA,"6047",12
"cladribine","A549","trt_cp","up",0.543294306813131,1.98879408100067e-05,6.23466946078869e-05,1.06050907789274,1.06110454307986,22,2,"ADA; APAF1; DCK; DGUOK; PNP; POLA1; POLE; POLE2; POLE3; POLE4; RRM1; RRM2; RRM2B","Adenosine deaminase inhibitor; Ribonucleoside reductase inhibitor","20279",12
"epibatidine","A375","trt_cp","down",-0.49260600849463,2.20638643121956e-05,6.23466946078869e-05,-1.01720159718829,-0.642313779743591,22,2,"CHRNA1; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; STXBP5","Acetylcholine receptor agonist","1204",12
"dorsomorphin","HCC515","trt_cp","up",0.481249289793385,2.25860859527209e-05,6.23466946078869e-05,0.967008047326374,0.954913213059214,22,2,"ACVR1; BMPR1A; BMPR1B; EPHA2; FKBP1A; FLT1; FLT3; KDR; LCK; MKNK1; PRKAA1; RPS6KA1; SRC","AMPK inhibitor","11524144",12
"dorsomorphin","PC3","trt_cp","up",0.466936014805151,2.31953445333338e-05,6.23466946078869e-05,0.947809897695961,0.954913213059214,22,2,"ACVR1; BMPR1A; BMPR1B; EPHA2; FKBP1A; FLT1; FLT3; KDR; LCK; MKNK1; PRKAA1; RPS6KA1; SRC","AMPK inhibitor","11524144",12
"BMS-536924","A375","trt_cp","up",0.483531472227437,2.24555305425896e-05,6.23466946078869e-05,0.946324257112626,0.601808342202172,22,2,"AKT1; CCNE1; CDK2; CYP3A4; ERBB2; IGF1R; INSR; KDR; LCK; MET; PDGFRA; PDGFRB; RET","IGF-1 inhibitor","11353973",12
"benidipine","PC3","trt_cp","up",0.449536554289759,2.39351585240781e-05,6.23466946078869e-05,0.912491609176409,0.0091249160917643,22,2,"CACNA1B; CACNA1C; CACNA1D; CACNA1F; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4; CYP3A5","Calcium channel blocker","656667",12
"dorsomorphin","MCF7","trt_cp","up",0.455378922521606,2.37175661738592e-05,6.23466946078869e-05,0.902731752543051,0.954913213059214,22,2,"ACVR1; BMPR1A; BMPR1B; EPHA2; FKBP1A; FLT1; FLT3; KDR; LCK; MKNK1; PRKAA1; RPS6KA1; SRC","AMPK inhibitor","11524144",12
"BMS-536924","HA1E","trt_cp","up",0.474774256990199,2.28471967729836e-05,6.23466946078869e-05,0.881171172527124,0.601808342202172,22,2,"AKT1; CCNE1; CDK2; CYP3A4; ERBB2; IGF1R; INSR; KDR; LCK; MET; PDGFRA; PDGFRB; RET","IGF-1 inhibitor","11353973",12
"BMS-536924","VCAP","trt_cp","up",0.427673309376303,2.48925648650412e-05,6.23466946078869e-05,0.872186003191553,0.601808342202172,22,2,"AKT1; CCNE1; CDK2; CYP3A4; ERBB2; IGF1R; INSR; KDR; LCK; MET; PDGFRA; PDGFRB; RET","IGF-1 inhibitor","11353973",12
"dorsomorphin","NPC","trt_cp","up",0.442741108007711,2.42397878143845e-05,6.23466946078869e-05,0.867934902523126,0.954913213059214,22,2,"ACVR1; BMPR1A; BMPR1B; EPHA2; FKBP1A; FLT1; FLT3; KDR; LCK; MKNK1; PRKAA1; RPS6KA1; SRC","AMPK inhibitor","11524144",12
"diacerein","PC3","trt_cp","up",0.394877700304064,2.63286743764859e-05,6.23466946078869e-05,0.801542354542499,0.537033377543474,22,2,"ALOX5; CYP1A2; CYP2C9; CYP2D6; CYP2E1; CYP3A4; CYP3A43; CYP3A5; CYP3A7; CYP3A7-CYP3A51P; IL1B; NR1H2; NR1H3",NA,"26248",12
"epibatidine","HT29","trt_cp","down",-0.308430780497242,0.000240221954641656,0.000499915778993431,-0.634663007959005,-0.642313779743591,22,2,"CHRNA1; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; STXBP5","Acetylcholine receptor agonist","1204",12
"levomepromazine","A549","trt_cp","down",-0.663754685947456,1.46222059347095e-05,6.23466946078869e-05,-1.38926464919272,-0.948576568514849,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; CHRM1; CHRM4; CHRM5; DRD1; DRD3; DRD4; HRH1","Dopamine receptor antagonist","45479743",11
"raloxifene","PHH","trt_cp","up",0.557296838896033,1.92786822293938e-05,6.23466946078869e-05,1.16230942007218,0.0329503394524626,22,2,"ACVRL1; AOX1; BGLAP; EBP; ENG; ESR1; ESR2; PTGR1; RAC1; SERPINB9; SHBG; TFF1","Estrogen receptor antagonist; Selective estrogen receptor modulator (SERM)","5035",11
"pepstatin","PC3","trt_cp","down",-0.542468546430184,1.99314592800504e-05,6.23466946078869e-05,-1.12153773611969,-1.0550640945358,22,2,"ALPL; CTSB; CTSD; CTSE; CTSL; IL18; MS4A1; NAPSA; PGA3; PGA4; PGA5; REN","Aspartic protease inhibitor","5478883",11
"pepstatin","A375","trt_cp","down",-0.516910198685918,2.10194210311449e-05,6.23466946078869e-05,-1.0673882791504,-1.0550640945358,22,2,"ALPL; CTSB; CTSD; CTSE; CTSL; IL18; MS4A1; NAPSA; PGA3; PGA4; PGA5; REN","Aspartic protease inhibitor","5478883",11
"levomepromazine","PC3","trt_cp","down",-0.51608441209521,2.10629395011887e-05,6.23466946078869e-05,-1.06698931578039,-0.948576568514849,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; CHRM1; CHRM4; CHRM5; DRD1; DRD3; DRD4; HRH1","Dopamine receptor antagonist","45479743",11
"raloxifene","HA1E","trt_cp","up",0.570150402518312,1.87129421188247e-05,6.23466946078869e-05,1.05818732019888,0.0329503394524626,22,2,"ACVRL1; AOX1; BGLAP; EBP; ENG; ESR1; ESR2; PTGR1; RAC1; SERPINB9; SHBG; TFF1","Estrogen receptor antagonist; Selective estrogen receptor modulator (SERM)","5035",11
"pepstatin","A549","trt_cp","down",-0.503962145407335,2.1585161141714e-05,6.23466946078869e-05,-1.05481258056408,-1.0550640945358,22,2,"ALPL; CTSB; CTSD; CTSE; CTSL; IL18; MS4A1; NAPSA; PGA3; PGA4; PGA5; REN","Aspartic protease inhibitor","5478883",11
"levomepromazine","SKB","trt_cp","down",-0.472908499687688,2.29342337130712e-05,6.23466946078869e-05,-1.01809011318238,-0.948576568514849,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; CHRM1; CHRM4; CHRM5; DRD1; DRD3; DRD4; HRH1","Dopamine receptor antagonist","45479743",11
"pepstatin","VCAP","trt_cp","down",-0.471911267341677,2.29777521831149e-05,6.23466946078869e-05,-0.982800090159122,-1.0550640945358,22,2,"ALPL; CTSB; CTSD; CTSE; CTSL; IL18; MS4A1; NAPSA; PGA3; PGA4; PGA5; REN","Aspartic protease inhibitor","5478883",11
"raloxifene","HT29","trt_cp","up",0.474877956216068,2.28471967729836e-05,6.23466946078869e-05,0.977888807878689,0.0329503394524626,22,2,"ACVRL1; AOX1; BGLAP; EBP; ENG; ESR1; ESR2; PTGR1; RAC1; SERPINB9; SHBG; TFF1","Estrogen receptor antagonist; Selective estrogen receptor modulator (SERM)","5035",11
"levomepromazine","VCAP","trt_cp","down",-0.454445834338036,2.37610846439029e-05,6.23466946078869e-05,-0.946426665071523,-0.948576568514849,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; CHRM1; CHRM4; CHRM5; DRD1; DRD3; DRD4; HRH1","Dopamine receptor antagonist","45479743",11
"levomepromazine","NPC","trt_cp","down",-0.449706296366642,2.39351585240781e-05,6.23466946078869e-05,-0.922047725678933,-0.948576568514849,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; CHRM1; CHRM4; CHRM5; DRD1; DRD3; DRD4; HRH1","Dopamine receptor antagonist","45479743",11
"cinnarizine","SKB","trt_cp","down",-0.416394685167615,2.54147865055665e-05,6.23466946078869e-05,-0.896425656191002,-0.0227210205956086,22,2,"CACNA1C; CACNA1D; CACNA1F; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CHRM1; CHRM4; CHRM5; DRD1; HRH1","Calcium channel blocker","1547484",11
"raloxifene","HEPG2","trt_cp","up",0.441821018279756,2.42833062844283e-05,6.23466946078869e-05,0.823758486311546,0.0329503394524626,22,2,"ACVRL1; AOX1; BGLAP; EBP; ENG; ESR1; ESR2; PTGR1; RAC1; SERPINB9; SHBG; TFF1","Estrogen receptor antagonist; Selective estrogen receptor modulator (SERM)","5035",11
"metoprolol","SKB","trt_cp","down",-0.368958490854076,2.74601545976241e-05,6.23466946078869e-05,-0.794303743665627,0,22,2,"ADRB1; ADRB2; CASR; CX3CR1; GRM7; GRPR; HTR1E; HTR1F; HTR5A; NMBR; PTGIR; SSTR3","Adrenergic receptor antagonist","5702086",11
"cinnarizine","MCF7","trt_cp","down",-0.372843115398555,2.7286080717449e-05,6.23466946078869e-05,-0.764129018330174,-0.0227210205956086,22,2,"CACNA1C; CACNA1D; CACNA1F; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CHRM1; CHRM4; CHRM5; DRD1; HRH1","Calcium channel blocker","1547484",11
"cinnarizine","NPC","trt_cp","down",-0.369387460003683,2.74601545976241e-05,6.23466946078869e-05,-0.757367353186958,-0.0227210205956086,22,2,"CACNA1C; CACNA1D; CACNA1F; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CHRM1; CHRM4; CHRM5; DRD1; HRH1","Calcium channel blocker","1547484",11
"cortisol","MCF7","trt_cp","down",-0.360157060614264,2.78953392980619e-05,6.23466946078869e-05,-0.73812938956288,-0.717095685876382,22,2,"ADIPOQ; AKR1D1; ANXA1; CYP11B1; CYP21A2; HSD11B2; HSD3B1; HSD3B2; LPL; POMC; RETN; SERPINA6",NA,"73707472",11
"cortisol","PC3","trt_cp","down",-0.326191296078765,5.94027116097573e-05,0.000125657584107618,-0.674390893543188,-0.717095685876382,22,2,"ADIPOQ; AKR1D1; ANXA1; CYP11B1; CYP21A2; HSD11B2; HSD3B1; HSD3B2; LPL; POMC; RETN; SERPINA6",NA,"73707472",11
"lidocaine","MCF7","trt_cp","down",-0.750310297662172,1.08796175109446e-05,6.23466946078869e-05,-1.53773490113327,-0.965480361047725,22,2,"CES2; CES5A; EGFR; LTF; ORM1; ORM2; SCN10A; SCN4A; SCN5A; SCN9A; TF","Histamine receptor agonist","3676",10
"lidocaine","HCC515","trt_cp","down",-0.646141231090129,1.54055383954975e-05,6.23466946078869e-05,-1.31683920478534,-0.965480361047725,22,2,"CES2; CES5A; EGFR; LTF; ORM1; ORM2; SCN10A; SCN4A; SCN5A; SCN9A; TF","Histamine receptor agonist","3676",10
"PI-103","A375","trt_cp","up",0.664051478009386,1.46222059347095e-05,6.23466946078869e-05,1.29962175722906,0.708852860088379,22,2,"MLST8; MTOR; PIK3C2B; PIK3C2G; PIK3C3; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3R1; PRKDC","MTOR inhibitor; PI3K inhibitor","9884685",10
"PI-103","NEU","trt_cp","up",0.667912303836887,1.44481320545344e-05,6.23466946078869e-05,1.24107146902649,0.708852860088379,22,2,"MLST8; MTOR; PIK3C2B; PIK3C2G; PIK3C3; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3R1; PRKDC","MTOR inhibitor; PI3K inhibitor","9884685",10
"PI-103","HS578T","trt_cp","up",0.633288332768003,1.59712785060666e-05,6.23466946078869e-05,1.15222921251343,0.708852860088379,22,2,"MLST8; MTOR; PIK3C2B; PIK3C2G; PIK3C3; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3R1; PRKDC","MTOR inhibitor; PI3K inhibitor","9884685",10
"lidocaine","PHH","trt_cp","down",-0.504877457410783,2.15416426716702e-05,6.23466946078869e-05,-1.0375194074651,-0.965480361047725,22,2,"CES2; CES5A; EGFR; LTF; ORM1; ORM2; SCN10A; SCN4A; SCN5A; SCN9A; TF","Histamine receptor agonist","3676",10
"PI-103","SKBR3","trt_cp","up",0.491691802621501,2.21073827822394e-05,6.23466946078869e-05,1.02479768540096,0.708852860088379,22,2,"MLST8; MTOR; PIK3C2B; PIK3C2G; PIK3C3; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3R1; PRKDC","MTOR inhibitor; PI3K inhibitor","9884685",10
"clofibrate","PC3","trt_cp","down",-0.473945333739204,2.28907152430274e-05,6.23466946078869e-05,-0.979868012890898,-0.0216263930875088,22,2,"ACOX1; APOA1; APOB; CAT; CRAT; CYP2E1; CYP4A11; EPHX1; GNPAT; LPL; PPARA","PPAR receptor agonist","2796",10
"lidocaine","PC3","trt_cp","down",-0.465908622548583,2.32388630033776e-05,6.23466946078869e-05,-0.963252349302858,-0.965480361047725,22,2,"CES2; CES5A; EGFR; LTF; ORM1; ORM2; SCN10A; SCN4A; SCN5A; SCN9A; TF","Histamine receptor agonist","3676",10
"PI-103","HA1E","trt_cp","up",0.516208229064478,2.10629395011887e-05,6.23466946078869e-05,0.958071765214277,0.708852860088379,22,2,"MLST8; MTOR; PIK3C2B; PIK3C2G; PIK3C3; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3R1; PRKDC","MTOR inhibitor; PI3K inhibitor","9884685",10
"acetazolamide","PC3","trt_cp","up",0.463649285225882,2.33258999434652e-05,6.23466946078869e-05,0.941138330869871,0.630562681682814,22,2,"AQP1; CA1; CA12; CA13; CA14; CA3; CA4; CA5A; CA5B; CA6; CA7",NA,"1986",10
"NCH-51","NPC","trt_cp","up",0.471296243600949,2.30212706531587e-05,6.23466946078869e-05,0.923913438013487,0.273029352309053,22,2,"HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9","HDAC inhibitor","11395181",10
"lidocaine","VCAP","trt_cp","down",-0.426598664713084,2.4936083335085e-05,6.23466946078869e-05,-0.888432286229401,-0.965480361047725,22,2,"CES2; CES5A; EGFR; LTF; ORM1; ORM2; SCN10A; SCN4A; SCN5A; SCN9A; TF","Histamine receptor agonist","3676",10
"clofibrate","NPC","trt_cp","down",-0.419498809593673,2.52842310954352e-05,6.23466946078869e-05,-0.860112314272586,-0.0216263930875088,22,2,"ACOX1; APOA1; APOB; CAT; CRAT; CYP2E1; CYP4A11; EPHX1; GNPAT; LPL; PPARA","PPAR receptor agonist","2796",10
"NCH-51","MCF7","trt_cp","up",0.393509753418739,2.63721928465296e-05,6.23466946078869e-05,0.780083863740153,0.273029352309053,22,2,"HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9","HDAC inhibitor","11395181",10
"clofibrate","PHH","trt_cp","down",-0.350794349047872,2.88745048740469e-05,6.35333115958871e-05,-0.720879769583632,-0.0216263930875088,22,2,"ACOX1; APOA1; APOB; CAT; CRAT; CYP2E1; CYP4A11; EPHX1; GNPAT; LPL; PPARA","PPAR receptor agonist","2796",10
"PI-103","MCF7","trt_cp","up",0.350960895722679,2.88745048740469e-05,6.35333115958871e-05,0.695736075608068,0.708852860088379,22,2,"MLST8; MTOR; PIK3C2B; PIK3C2G; PIK3C3; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3R1; PRKDC","MTOR inhibitor; PI3K inhibitor","9884685",10
"atomoxetine","MCF7","trt_cp","down",-0.714661671473284,1.24027639624768e-05,6.23466946078869e-05,-1.46467427962919,-0.780789864027494,22,2,"GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B; SLC6A2; SLC6A3; SLC6A4","Norepinephrine transporter inhibitor","54840",9
"SU-6656","PC3","trt_cp","down",-0.52652843359182,2.05842363307071e-05,6.23466946078869e-05,-1.0885820224956,-0.010885820224956,22,2,"AURKB; AURKC; BRSK2; CALM1; CAMK2D; LCK; LYN; RET; SRC; YES1","SRC inhibitor","5312137",9
"ketoconazole","MCF7","trt_cp","up",0.473225971463457,2.29342337130712e-05,6.23466946078869e-05,0.938111294661043,0.787464977703761,22,2,"AR; CYP19A1; CYP21A2; CYP3A5; CYP3A7; CYP51A1; KCNA10; KCNH2; NR1I2; NR1I3","Sterol demethylase inhibitor","3823",9
"phenelzine","A549","trt_cp","down",-0.420818615770776,2.51971941553476e-05,6.23466946078869e-05,-0.880789904749291,-0.748507394279707,22,2,"ABAT; AOC3; GAD2; GPT; GPT2; MAOA; MAOB; SLC6A2; SLC6A3; SLC6A4","Monoamine oxidase inhibitor","61100",9
"melatonin","PC3","trt_cp","up",0.422074565260841,2.51536756853038e-05,6.23466946078869e-05,0.856747900859354,0.574021093575767,22,2,"ASMT; CALM1; CALM2; CALM3; CALR; EPX; MPO; MTNR1A; MTNR1B; NQO2",NA,"896",9
"atomoxetine","VCAP","trt_cp","down",-0.407899989889644,2.57629342659167e-05,6.23466946078869e-05,-0.8494905177782,-0.780789864027494,22,2,"GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B; SLC6A2; SLC6A3; SLC6A4","Norepinephrine transporter inhibitor","54840",9
"phenelzine","VCAP","trt_cp","down",-0.358769311166374,2.79388577681057e-05,6.23466946078869e-05,-0.747171207305267,-0.748507394279707,22,2,"ABAT; AOC3; GAD2; GPT; GPT2; MAOA; MAOB; SLC6A2; SLC6A3; SLC6A4","Monoamine oxidase inhibitor","61100",9
"atomoxetine","A549","trt_cp","down",-0.355367049788505,2.83087647634778e-05,6.27481596233244e-05,-0.743797204315575,-0.780789864027494,22,2,"GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B; SLC6A2; SLC6A3; SLC6A4","Norepinephrine transporter inhibitor","54840",9
"ketoconazole","VCAP","trt_cp","up",0.348076986560162,2.97013558048787e-05,6.4945306531332e-05,0.709859299271222,0.787464977703761,22,2,"AR; CYP19A1; CYP21A2; CYP3A5; CYP3A7; CYP51A1; KCNA10; KCNH2; NR1I2; NR1I3","Sterol demethylase inhibitor","3823",9
"ibutilide","PC3","trt_cp","down",-0.313436114012058,0.000155447974996376,0.000324760973720664,-0.648019930446748,-0.434173353399321,22,2,"CACNA1C; CACNA2D1; CACNB1; CACNG1; KCNH2; KCNH6; KCNH7; KCNJ11; KCNK1; KCNK6",NA,"73707513",9
"diltiazem","A549","trt_cp","up",0.675799433404857,1.40999842941842e-05,6.23466946078869e-05,1.3191587413544,0.0286678016766946,22,2,"CACNA1C; CACNA1S; CACNA2D1; CACNG1; CYP3A5; CYP3A7; EDN1; HTR3A; KCNA5","Calcium channel blocker","39186",8
"purvalanol-a","VCAP","trt_cp","up",0.629159277090222,1.61453523862417e-05,6.23466946078869e-05,1.28309132982011,0.895344610572043,22,2,"CCND1; CCNE1; CDK1; CDK2; CDK4; CDK5; CSNK1G3; RPS6KA1; SRC","CDK inhibitor; DYRK inhibitor","456214",8
"HG-6-64-01","SKB","trt_cp","up",0.620433648393027,1.65370186166357e-05,6.23466946078869e-05,1.23370706035133,0.979652511136289,22,2,"ABL1; BRAF; CSF1R; EGFR; FLT3; KIT; MAPK11; PDGFRB; RET","RAF inhibitor","53302361",8
"methysergide","MCF7","trt_cp","down",-0.59766704182352,1.74944249575989e-05,6.23466946078869e-05,-1.224897848707,-0.749535605012938,22,2,"ADCY10; HTR1B; HTR1D; HTR1E; HTR1F; HTR2B; HTR5A; HTR6; HTR7","Serotonin receptor antagonist","4163",8
"strophanthidin","PC3","trt_cp","up",0.584151908531851,1.81036835382118e-05,6.23466946078869e-05,1.18574053641057,0.0312938595860001,22,2,"ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP1B4; FXYD2","ATPase inhibitor","6185",8
"cinobufagin","PC3","trt_cp","up",0.579198742387327,1.83212758884307e-05,6.23466946078869e-05,1.17568635393619,0.913588403983055,22,2,"ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP1B4; FXYD2","ATPase inhibitor","23947601",8
"WHI-P154","MCF7","trt_cp","up",0.565350457039453,1.89305344690436e-05,6.23466946078869e-05,1.12073656386682,0,22,2,"ALK; ERBB4; LTK; MAP4K5; MKNK2; PTK6; RET; STK10; TNK2",NA,"23863723",8
"5-methoxytryptamine","SKB","trt_cp","down",-0.505042818922041,2.15416426716702e-05,6.23466946078869e-05,-1.08726973826407,-0.548231838163583,22,2,"HTR1B; HTR1D; HTR1E; HTR1F; HTR4; HTR5A; HTR6; HTR7; TRPM8","Serotonin receptor agonist","1833",8
"HG-6-64-01","A549","trt_cp","up",0.554960427421318,1.93657191694813e-05,6.23466946078869e-05,1.08328131506442,0.979652511136289,22,2,"ABL1; BRAF; CSF1R; EGFR; FLT3; KIT; MAPK11; PDGFRB; RET","RAF inhibitor","53302361",8
"HG-6-64-01","NEU","trt_cp","up",0.581563490250497,1.81907204782993e-05,6.23466946078869e-05,1.08062368522204,0.979652511136289,22,2,"ABL1; BRAF; CSF1R; EGFR; FLT3; KIT; MAPK11; PDGFRB; RET","RAF inhibitor","53302361",8
"acitretin","NEU","trt_cp","down",-0.536318255534111,2.01925701003131e-05,6.23466946078869e-05,-1.07034012660408,0,22,2,"CRABP1; RARA; RARB; RARG; RBP1; RXRA; RXRB; RXRG; STAT3","Retinoid receptor agonist","5284513",8
"diltiazem","NPC","trt_cp","up",0.543428744195066,1.98879408100067e-05,6.23466946078869e-05,1.06531958652684,0.0286678016766946,22,2,"CACNA1C; CACNA1S; CACNA2D1; CACNG1; CYP3A5; CYP3A7; EDN1; HTR3A; KCNA5","Calcium channel blocker","39186",8
"strophanthidin","VCAP","trt_cp","up",0.520749043832511,2.08453471509698e-05,6.23466946078869e-05,1.06200227427909,0.0312938595860001,22,2,"ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP1B4; FXYD2","ATPase inhibitor","6185",8
"strophanthidin","SKB","trt_cp","up",0.524591401509091,2.06712732707947e-05,6.23466946078869e-05,1.04312865286666,0.0312938595860001,22,2,"ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP1B4; FXYD2","ATPase inhibitor","6185",8
"tyramine","FIBRNPC","trt_cp","up",0.52625374167627,2.06277548007509e-05,6.23466946078869e-05,1.04265112269197,0.354501381715269,22,2,"AOC2; AOC3; DDC; TAAR1; TAAR2; TAAR5; TAAR6; TAAR8; TYR",NA,"153005",8
"cinobufagin","SKB","trt_cp","up",0.521179001062084,2.08453471509698e-05,6.23466946078869e-05,1.03634323345054,0.913588403983055,22,2,"ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP1B4; FXYD2","ATPase inhibitor","23947601",8
"acitretin","VCAP","trt_cp","down",-0.493440181888118,2.20638643121956e-05,6.23466946078869e-05,-1.02763610197223,0,22,2,"CRABP1; RARA; RARB; RARG; RBP1; RXRA; RXRB; RXRG; STAT3","Retinoid receptor agonist","5284513",8
"HG-6-64-01","VCAP","trt_cp","up",0.499265522622214,2.18027534919329e-05,6.23466946078869e-05,1.0181893308756,0.979652511136289,22,2,"ABL1; BRAF; CSF1R; EGFR; FLT3; KIT; MAPK11; PDGFRB; RET","RAF inhibitor","53302361",8
"milnacipran","A549","trt_cp","up",0.52024634599019,2.08888656210136e-05,6.23466946078869e-05,1.01551951814009,0.0101551951814011,22,2,"GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B; SLC6A2; SLC6A4","Serotonin reuptake inhibitor","163701",8
"purvalanol-a","A549","trt_cp","up",0.511922631184647,2.12370133813638e-05,6.23466946078869e-05,0.999271648426804,0.895344610572043,22,2,"CCND1; CCNE1; CDK1; CDK2; CDK4; CDK5; CSNK1G3; RPS6KA1; SRC","CDK inhibitor; DYRK inhibitor","456214",8
"clotrimazole","VCAP","trt_cp","up",0.485136443427094,2.24120120725458e-05,6.23466946078869e-05,0.989374848321286,0.687291190802198,22,2,"CYP3A4; CYP46A1; CYP51A1; KCNN4; NR1I2; NR1I3; TRPM2; TRPM4; TRPM8","Cytochrome P450 inhibitor; Imidazoline receptor ligand","2812",8
"HG-6-64-01","MCF10A","trt_cp","up",0.469191086175473,2.31083075932463e-05,6.23466946078869e-05,0.957019775733838,0.979652511136289,22,2,"ABL1; BRAF; CSF1R; EGFR; FLT3; KIT; MAPK11; PDGFRB; RET","RAF inhibitor","53302361",8
"diltiazem","SKB","trt_cp","up",0.480569749424255,2.25860859527209e-05,6.23466946078869e-05,0.955593389223144,0.0286678016766946,22,2,"CACNA1C; CACNA1S; CACNA2D1; CACNG1; CYP3A5; CYP3A7; EDN1; HTR3A; KCNA5","Calcium channel blocker","39186",8
"orantinib","MCF7","trt_cp","down",-0.464570475964754,2.32823814734214e-05,6.23466946078869e-05,-0.952121058651321,-0.868942476614603,22,2,"AURKA; AURKB; EGFR; FGFR2; IKBKE; KDR; PDGFRA; PDGFRB; TBK1","FGFR inhibitor; PDGFR receptor inhibitor; VEGFR inhibitor","5329099",8
"orantinib","ASC","trt_cp","down",-0.459070318806923,2.3543492293684e-05,6.23466946078869e-05,-0.921473055080551,-0.868942476614603,22,2,"AURKA; AURKB; EGFR; FGFR2; IKBKE; KDR; PDGFRA; PDGFRB; TBK1","FGFR inhibitor; PDGFR receptor inhibitor; VEGFR inhibitor","5329099",8
"methysergide","PHH","trt_cp","down",-0.447383348637205,2.40657139342094e-05,6.23466946078869e-05,-0.919369442969931,-0.749535605012938,22,2,"ADCY10; HTR1B; HTR1D; HTR1E; HTR1F; HTR2B; HTR5A; HTR6; HTR7","Serotonin receptor antagonist","4163",8
"cinobufagin","MCF7","trt_cp","up",0.463013115304469,2.33694184135089e-05,6.23466946078869e-05,0.917865584807319,0.913588403983055,22,2,"ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP1B4; FXYD2","ATPase inhibitor","23947601",8
"HG-6-64-01","BT20","trt_cp","up",0.455454043616995,2.37175661738592e-05,6.23466946078869e-05,0.916943584381007,0.979652511136289,22,2,"ABL1; BRAF; CSF1R; EGFR; FLT3; KIT; MAPK11; PDGFRB; RET","RAF inhibitor","53302361",8
"orantinib","SKB","trt_cp","down",-0.422819827580929,2.51101572152601e-05,6.23466946078869e-05,-0.910257875258969,-0.868942476614603,22,2,"AURKA; AURKB; EGFR; FGFR2; IKBKE; KDR; PDGFRA; PDGFRB; TBK1","FGFR inhibitor; PDGFR receptor inhibitor; VEGFR inhibitor","5329099",8
"methysergide","HCC515","trt_cp","down",-0.444076055559223,2.41962693443407e-05,6.23466946078869e-05,-0.905029321345456,-0.749535605012938,22,2,"ADCY10; HTR1B; HTR1D; HTR1E; HTR1F; HTR2B; HTR5A; HTR6; HTR7","Serotonin receptor antagonist","4163",8
"cinobufagin","NPC","trt_cp","up",0.461173029809106,2.34564553535965e-05,6.23466946078869e-05,0.904068227309694,0.913588403983055,22,2,"ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP1B4; FXYD2","ATPase inhibitor","23947601",8
"5-methoxytryptamine","MCF7","trt_cp","down",-0.437503488331277,2.44573801646034e-05,6.23466946078869e-05,-0.89664820737602,-0.548231838163583,22,2,"HTR1B; HTR1D; HTR1E; HTR1F; HTR4; HTR5A; HTR6; HTR7; TRPM8","Serotonin receptor agonist","1833",8
"purvalanol-a","HA1E","trt_cp","up",0.481268121641992,2.25860859527209e-05,6.23466946078869e-05,0.893223650615823,0.895344610572043,22,2,"CCND1; CCNE1; CDK1; CDK2; CDK4; CDK5; CSNK1G3; RPS6KA1; SRC","CDK inhibitor; DYRK inhibitor","456214",8
"prostaglandin-e1","PC3","trt_cp","up",0.425816737001109,2.49796018051287e-05,6.23466946078869e-05,0.864343946788225,0.579110444348111,22,2,"CATSPER1; CATSPER2; CATSPER3; CATSPER4; PTGDR; PTGER1; PTGER2; PTGER4; PTGIR","Prostanoid receptor agonist","149351",8
"HG-6-64-01","HS578T","trt_cp","up",0.473133203553747,2.29342337130712e-05,6.23466946078869e-05,0.860836794769127,0.979652511136289,22,2,"ABL1; BRAF; CSF1R; EGFR; FLT3; KIT; MAPK11; PDGFRB; RET","RAF inhibitor","53302361",8
"orantinib","PC3","trt_cp","down",-0.409051810123155,2.5719415795873e-05,6.23466946078869e-05,-0.845702564877147,-0.868942476614603,22,2,"AURKA; AURKB; EGFR; FGFR2; IKBKE; KDR; PDGFRA; PDGFRB; TBK1","FGFR inhibitor; PDGFR receptor inhibitor; VEGFR inhibitor","5329099",8
"purvalanol-a","MCF7","trt_cp","up",0.424134277029515,2.50666387452163e-05,6.23466946078869e-05,0.840793151110915,0.895344610572043,22,2,"CCND1; CCNE1; CDK1; CDK2; CDK4; CDK5; CSNK1G3; RPS6KA1; SRC","CDK inhibitor; DYRK inhibitor","456214",8
"octopamine","FIBRNPC","trt_cp","up",0.416833421503618,2.53712680355227e-05,6.23466946078869e-05,0.825859847612517,0.442608573761361,22,2,"ADCY10; DBH; PNMT; TAAR1; TAAR2; TAAR5; TAAR6; TAAR8; TDP1",NA,"102484",8
"5-methoxytryptamine","PC3","trt_cp","down",-0.384304821901496,2.68073775469674e-05,6.23466946078869e-05,-0.79453889588925,-0.548231838163583,22,2,"HTR1B; HTR1D; HTR1E; HTR1F; HTR4; HTR5A; HTR6; HTR7; TRPM8","Serotonin receptor agonist","1833",8
"purvalanol-a","A375","trt_cp","up",0.390158355932074,2.65462667267047e-05,6.23466946078869e-05,0.763582801824401,0.895344610572043,22,2,"CCND1; CCNE1; CDK1; CDK2; CDK4; CDK5; CSNK1G3; RPS6KA1; SRC","CDK inhibitor; DYRK inhibitor","456214",8
"cinobufagin","PHH","trt_cp","up",0.359183066272413,2.79388577681057e-05,6.23466946078869e-05,0.749119378257808,0.913588403983055,22,2,"ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP1B4; FXYD2","ATPase inhibitor","23947601",8
"methysergide","ASC","trt_cp","down",-0.371016645072464,2.73731176575365e-05,6.23466946078869e-05,-0.744726521002654,-0.749535605012938,22,2,"ADCY10; HTR1B; HTR1D; HTR1E; HTR1F; HTR2B; HTR5A; HTR6; HTR7","Serotonin receptor antagonist","4163",8
"cinobufagin","HA1E","trt_cp","up",0.372899467239937,2.7286080717449e-05,6.23466946078869e-05,0.692093675983233,0.913588403983055,22,2,"ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP1B4; FXYD2","ATPase inhibitor","23947601",8
"clotrimazole","MCF7","trt_cp","up",0.345161672377769,3.03976513255791e-05,6.61092453891588e-05,0.684239840726248,0.687291190802198,22,2,"CYP3A4; CYP46A1; CYP51A1; KCNN4; NR1I2; NR1I3; TRPM2; TRPM4; TRPM8","Cytochrome P450 inhibitor; Imidazoline receptor ligand","2812",8
"octopamine","MCF7","trt_cp","up",0.328340999824538,5.31360519234533e-05,0.000112608734249215,0.650894961413766,0.442608573761361,22,2,"ADCY10; DBH; PNMT; TAAR1; TAAR2; TAAR5; TAAR6; TAAR8; TDP1",NA,"102484",8
"ropinirole","HCC515","trt_cp","down",-0.663659140238183,1.46222059347095e-05,6.23466946078869e-05,-1.35254079515298,-1.05583852374865,22,2,"ADRA2B; ADRA2C; DRD1; DRD3; DRD4; HTR1B; HTR1D; HTR2B","Dopamine receptor agonist","5095",7
"isradipine","VCAP","trt_cp","down",-0.626997754721519,1.62323893263293e-05,6.23466946078869e-05,-1.3057824479188,-0.764879636752805,22,2,"CACNA1C; CACNA1D; CACNA1F; CACNA1H; CACNA1S; CACNA2D1; CACNA2D2; CACNB2","Calcium channel blocker","3784",7
"isradipine","MCF7","trt_cp","down",-0.629550134757529,1.6101833916198e-05,6.23466946078869e-05,-1.29024114056033,-0.764879636752805,22,2,"CACNA1C; CACNA1D; CACNA1F; CACNA1H; CACNA1S; CACNA2D1; CACNA2D2; CACNB2","Calcium channel blocker","3784",7
"isradipine","HT29","trt_cp","down",-0.598571227575532,1.74509064875551e-05,6.23466946078869e-05,-1.23168970087341,-0.764879636752805,22,2,"CACNA1C; CACNA1D; CACNA1F; CACNA1H; CACNA1S; CACNA2D1; CACNA2D2; CACNB2","Calcium channel blocker","3784",7
"ropinirole","VCAP","trt_cp","down",-0.587150359694115,1.79731281280804e-05,6.23466946078869e-05,-1.22279645852689,-1.05583852374865,22,2,"ADRA2B; ADRA2C; DRD1; DRD3; DRD4; HTR1B; HTR1D; HTR2B","Dopamine receptor agonist","5095",7
"gavestinel","PC3","trt_cp","up",0.58135660947743,1.82342389483431e-05,6.23466946078869e-05,1.18006649965437,1.04274668409053,22,2,"GLRB; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B","Glutamate receptor antagonist","6450546",7
"ropinirole","SKB","trt_cp","down",-0.545133627952223,1.98009038699191e-05,6.23466946078869e-05,-1.17357830816727,-1.05583852374865,22,2,"ADRA2B; ADRA2C; DRD1; DRD3; DRD4; HTR1B; HTR1D; HTR2B","Dopamine receptor agonist","5095",7
"gavestinel","MCF7","trt_cp","up",0.587288389666388,1.79731281280804e-05,6.23466946078869e-05,1.16422577117976,1.04274668409053,22,2,"GLRB; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B","Glutamate receptor antagonist","6450546",7
"PHA-793887","NPC","trt_cp","up",0.579683213415939,1.82777574183869e-05,6.23466946078869e-05,1.13639163888457,0,22,2,"CCND1; CCNE1; CDK1; CDK2; CDK4; CDK5; CDK7; CDK9","CDK inhibitor","46191454",7
"A-443644","NPC","trt_cp","up",0.571394057516978,1.86694236487809e-05,6.23466946078869e-05,1.12014185410733,1.01516578682153,22,2,"AKT1; AKT2; AKT3; CDC42BPB; GSK3B; PHKG1; PKIA; PRKACA","AKT inhibitor","10172943",7
"cyproheptadine","MCF7","trt_cp","up",0.562573724848576,1.90175714091311e-05,6.23466946078869e-05,1.11523203962768,0.969233460974654,22,2,"ADRA1A; ADRA1B; ADRA1D; CHRM1; HRH1; HTR2B; HTR6; HTR7","Histamine receptor antagonist","2913",7
"A-443644","ASC","trt_cp","up",0.52307897168746,2.07583102108822e-05,6.23466946078869e-05,1.10447877833031,1.01516578682153,22,2,"AKT1; AKT2; AKT3; CDC42BPB; GSK3B; PHKG1; PKIA; PRKACA","AKT inhibitor","10172943",7
"A-443644","VCAP","trt_cp","up",0.533318419954029,2.03231255104445e-05,6.23466946078869e-05,1.08763593829714,1.01516578682153,22,2,"AKT1; AKT2; AKT3; CDC42BPB; GSK3B; PHKG1; PKIA; PRKACA","AKT inhibitor","10172943",7
"indometacin","MCF7","trt_cp","down",-0.528221918896244,2.05407178606633e-05,6.23466946078869e-05,-1.08257248069393,-0.017945790657342,22,2,"AKR1C3; GLO1; PLA2G2A; PPARA; PPARG; PTGDR2; PTGR2; SLC46A1","Cyclooxygenase inhibitor","3715",7
"semaxanib","MCF7","trt_cp","up",0.545920244020716,1.97573853998753e-05,6.23466946078869e-05,1.08221859699747,0.746036920674129,22,2,"FLT1; FLT3; KDR; KIT; MET; PDGFRA; PDGFRB; RET","VEGFR inhibitor","5329098",7
"gavestinel","VCAP","trt_cp","up",0.527597930238026,2.05407178606633e-05,6.23466946078869e-05,1.07596971795485,1.04274668409053,22,2,"GLRB; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B","Glutamate receptor antagonist","6450546",7
"semaxanib","NPC","trt_cp","up",0.546689221273314,1.97138669298316e-05,6.23466946078869e-05,1.07171131705266,0.746036920674129,22,2,"FLT1; FLT3; KDR; KIT; MET; PDGFRA; PDGFRB; RET","VEGFR inhibitor","5329098",7
"corticosterone","A549","trt_cp","up",0.543939322954994,1.98444223399629e-05,6.23466946078869e-05,1.06176814772884,0.966768064748492,22,2,"AKR1D1; CYP11B1; CYP21A2; HSD11B1; HSD11B1L; HSD11B2; NCOA1; NR3C2","mineralocorticoid receptor agonist","51414212",7
"ropinirole","ASC","trt_cp","down",-0.524195959466615,2.07147917408385e-05,6.23466946078869e-05,-1.05219708711714,-1.05583852374865,22,2,"ADRA2B; ADRA2C; DRD1; DRD3; DRD4; HTR1B; HTR1D; HTR2B","Dopamine receptor agonist","5095",7
"gavestinel","SKB","trt_cp","up",0.523882568652958,2.07147917408385e-05,6.23466946078869e-05,1.04171916757926,1.04274668409053,22,2,"GLRB; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B","Glutamate receptor antagonist","6450546",7
"PHA-793887","PC3","trt_cp","up",0.49687036328593,2.18897904320205e-05,6.23466946078869e-05,1.00857212393589,0,22,2,"CCND1; CCNE1; CDK1; CDK2; CDK4; CDK5; CDK7; CDK9","CDK inhibitor","46191454",7
"gavestinel","HA1E","trt_cp","up",0.525831464713219,2.06277548007509e-05,6.23466946078869e-05,0.975932290959421,1.04274668409053,22,2,"GLRB; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRIN3A; GRIN3B","Glutamate receptor antagonist","6450546",7
"A-443644","SKB","trt_cp","up",0.490028297235745,2.21944197223269e-05,6.23466946078869e-05,0.974401326616499,1.01516578682153,22,2,"AKT1; AKT2; AKT3; CDC42BPB; GSK3B; PHKG1; PKIA; PRKACA","AKT inhibitor","10172943",7
"cyproheptadine","VCAP","trt_cp","up",0.47453705552012,2.28471967729836e-05,6.23466946078869e-05,0.967758727856947,0.969233460974654,22,2,"ADRA1A; ADRA1B; ADRA1D; CHRM1; HRH1; HTR2B; HTR6; HTR7","Histamine receptor antagonist","2913",7
"corticosterone","MCF7","trt_cp","up",0.487197684426929,2.23249751324583e-05,6.23466946078869e-05,0.965808467950711,0.966768064748492,22,2,"AKR1D1; CYP11B1; CYP21A2; HSD11B1; HSD11B1L; HSD11B2; NCOA1; NR3C2","mineralocorticoid receptor agonist","51414212",7
"A-443644","PC3","trt_cp","up",0.47462934548181,2.28471967729836e-05,6.23466946078869e-05,0.963426202136792,1.01516578682153,22,2,"AKT1; AKT2; AKT3; CDC42BPB; GSK3B; PHKG1; PKIA; PRKACA","AKT inhibitor","10172943",7
"sumatriptan","A549","trt_cp","down",-0.448939888879906,2.39786769941218e-05,6.23466946078869e-05,-0.939648834784627,-0.612470587013911,22,2,"ADCY10; HTR1B; HTR1D; HTR1E; HTR1F; HTR5A; HTR6; HTR7","Serotonin receptor agonist","5358",7
"repaglinide","VCAP","trt_cp","down",-0.442859023859034,2.42397878143845e-05,6.23466946078869e-05,-0.922296030413091,-0.0138374135289398,22,2,"ABCC8; CYP2C8; CYP3A5; INS; KCNJ1; KCNJ11; PPARG; SLCO1B1","Insulin secretagogue","65981",7
"lacidipine","A549","trt_cp","up",0.469898095210101,2.30647891232025e-05,6.23466946078869e-05,0.917239863193013,0.00917239863193034,22,2,"CACNA1C; CACNA1D; CACNA1F; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4","Calcium channel blocker","5311217",7
"fludarabine","PHH","trt_cp","up",0.434385091533933,2.46314540447785e-05,6.23466946078869e-05,0.905962224420581,0,22,2,"ADA; BAX; DCK; MCL1; POLA1; RRM1; RRM2; SLC29A1","DNA repair enzyme inhibitor; DNA synthesis inhibitor; Purine antagonist","57007282",7
"indometacin","PC3","trt_cp","down",-0.434003540804166,2.46314540447785e-05,6.23466946078869e-05,-0.897289532867099,-0.017945790657342,22,2,"AKR1C3; GLO1; PLA2G2A; PPARA; PPARG; PTGDR2; PTGR2; SLC46A1","Cyclooxygenase inhibitor","3715",7
"gemcitabine","PC3","trt_cp","down",-0.423521485754809,2.50666387452163e-05,6.23466946078869e-05,-0.875618192902227,-0.297710185586757,22,2,"CMPK1; DCK; DCTD; RRM1; RRM2; SLC29A1; TK2; TYMS","Ribonucleotide reductase inhibitor","60749",7
"corticosterone","PC3","trt_cp","up",0.409991425128256,2.56758973258292e-05,6.23466946078869e-05,0.832220943311026,0.966768064748492,22,2,"AKR1D1; CYP11B1; CYP21A2; HSD11B1; HSD11B1L; HSD11B2; NCOA1; NR3C2","mineralocorticoid receptor agonist","51414212",7
"captopril","VCAP","trt_cp","up",0.382511651538117,2.68508960170112e-05,6.23466946078869e-05,0.780084473861057,0.265228721112759,22,2,"ACE; ACE2; AGT; ATP6AP2; BDKRB1; LTA4H; MMP2; MMP9","ACE inhibitor","44093",7
"isradipine","A375","trt_cp","down",-0.363420922386492,2.77647838879305e-05,6.23466946078869e-05,-0.750442212089281,-0.764879636752805,22,2,"CACNA1C; CACNA1D; CACNA1F; CACNA1H; CACNA1S; CACNA2D1; CACNA2D2; CACNB2","Calcium channel blocker","3784",7
"semaxanib","ASC","trt_cp","up",0.353933504820933,2.83958017035653e-05,6.28319833929919e-05,0.747328923878743,0.746036920674129,22,2,"FLT1; FLT3; KDR; KIT; MET; PDGFRA; PDGFRB; RET","VEGFR inhibitor","5329098",7
"semaxanib","SKB","trt_cp","up",0.375163303819796,2.71990437773614e-05,6.23466946078869e-05,0.74599696181213,0.746036920674129,22,2,"FLT1; FLT3; KDR; KIT; MET; PDGFRA; PDGFRB; RET","VEGFR inhibitor","5329098",7
"ropinirole","A549","trt_cp","down",-0.352340720730229,2.8656912523828e-05,6.31755287318929e-05,-0.737462978634763,-1.05583852374865,22,2,"ADRA2B; ADRA2C; DRD1; DRD3; DRD4; HTR1B; HTR1D; HTR2B","Dopamine receptor agonist","5095",7
"A-443644","A549","trt_cp","up",0.373769427321766,2.72425622474052e-05,6.23466946078869e-05,0.729596952779855,1.01516578682153,22,2,"AKT1; AKT2; AKT3; CDC42BPB; GSK3B; PHKG1; PKIA; PRKACA","AKT inhibitor","10172943",7
"niflumic-acid","VCAP","trt_cp","up",0.356361635038046,2.81782093533464e-05,6.2564392165542e-05,0.726754799376924,0.247096631788154,22,2,"ANO1; CLCN1; CLCNKA; CLCNKB; KCNQ1; PLA2G1B; PLA2G4A; UGT1A9","Cyclooxygenase inhibitor","4488",7
"fludarabine","A549","trt_cp","up",0.368174547831086,2.75036730676679e-05,6.23466946078869e-05,0.718675762524087,0,22,2,"ADA; BAX; DCK; MCL1; POLA1; RRM1; RRM2; SLC29A1","DNA repair enzyme inhibitor; DNA synthesis inhibitor; Purine antagonist","57007282",7
"ciprofibrate","NPC","trt_cp","up",0.364199777008098,2.77212654178868e-05,6.23466946078869e-05,0.713965096620217,0,22,2,"ACOX1; APOA1; APOB; CAT; CRAT; EHHADH; LPL; PPARA","PPAR receptor agonist","2763",7
"repaglinide","A375","trt_cp","down",-0.335056151367744,3.9057826864291e-05,8.35361609985273e-05,-0.691870676446989,-0.0138374135289398,22,2,"ABCC8; CYP2C8; CYP3A5; INS; KCNJ1; KCNJ11; PPARG; SLCO1B1","Insulin secretagogue","65981",7
"cyproheptadine","A549","trt_cp","up",0.342989773916539,3.13550576665423e-05,6.79406398285452e-05,0.669515149158336,0.969233460974654,22,2,"ADRA1A; ADRA1B; ADRA1D; CHRM1; HRH1; HTR2B; HTR6; HTR7","Histamine receptor antagonist","2913",7
"sumatriptan","MCF7","trt_cp","down",-0.297231557627034,0.000660088153624029,0.00136422968105531,-0.609165756228348,-0.612470587013911,22,2,"ADCY10; HTR1B; HTR1D; HTR1E; HTR1F; HTR5A; HTR6; HTR7","Serotonin receptor agonist","5358",7
"VX-702","PC3","trt_cp","up",0.668243688541559,1.44481320545344e-05,6.23466946078869e-05,1.3564342050952,1.06336946195339,22,2,"IL1B; IL6; MAPK11; MAPK12; MAPK14; NLK; TNF","p38 MAPK inhibitor","10341154",6
"picrotoxin","PHH","trt_cp","up",0.645935082754826,1.54055383954975e-05,6.23466946078869e-05,1.34717511215078,0.0294425379971042,22,2,"GABRR1; GLRA1; GLRA2; GLRA3; GLRB; HTR3A; HTR3B","GABA receptor antagonist","73707459",6
"chlorprothixene","PC3","trt_cp","up",0.652381853189071,1.51444275752348e-05,6.23466946078869e-05,1.32423706444632,0.899894023238087,22,2,"CHRM1; CHRM4; CHRM5; DRD1; DRD3; HRH1; HTR2B","Dopamine receptor antagonist","667467",6
"VX-702","A549","trt_cp","up",0.659578905367447,1.47962798148846e-05,6.23466946078869e-05,1.2874963126925,1.06336946195339,22,2,"IL1B; IL6; MAPK11; MAPK12; MAPK14; NLK; TNF","p38 MAPK inhibitor","10341154",6
"prostaglandin","SKB","trt_cp","down",-0.591163504991824,1.77990542479053e-05,6.23466946078869e-05,-1.27267266311324,-1.04782269381065,22,2,"AKR1C3; PTGDR; PTGDR2; PTGER1; PTGER2; PTGER4; PTGFR","Prostanoid receptor antagonist","13292831",6
"orlistat","VCAP","trt_cp","up",0.579091620499763,1.83212758884307e-05,6.23466946078869e-05,1.18098463217633,0.96604122264037,22,2,"CNR1; DAGLA; DAGLB; FASN; LIPF; LPL; PNLIP","Lipase inhibitor","3034010",6
"hydroflumethiazide","MCF7","trt_cp","down",-0.57300844412408,1.85823867086933e-05,6.23466946078869e-05,-1.17436090897209,-1.12679005110042,22,2,"ATP1A1; CA1; CA12; CA4; CA9; KCNMA1; SLC12A1","Sodium/potassium/chloride transporter inhibitor","3647",6
"hydroflumethiazide","A375","trt_cp","down",-0.567322842923657,1.8843497528956e-05,6.23466946078869e-05,-1.17148733874941,-1.12679005110042,22,2,"ATP1A1; CA1; CA12; CA4; CA9; KCNMA1; SLC12A1","Sodium/potassium/chloride transporter inhibitor","3647",6
"prostaglandin","PHH","trt_cp","down",-0.566521517401571,1.8843497528956e-05,6.23466946078869e-05,-1.16419749074373,-1.04782269381065,22,2,"AKR1C3; PTGDR; PTGDR2; PTGER1; PTGER2; PTGER4; PTGFR","Prostanoid receptor antagonist","13292831",6
"picrotoxin","VCAP","trt_cp","up",0.570412009189248,1.87129421188247e-05,6.23466946078869e-05,1.16328365497667,0.0294425379971042,22,2,"GABRR1; GLRA1; GLRA2; GLRA3; GLRB; HTR3A; HTR3B","GABA receptor antagonist","73707459",6
"nateglinide","A549","trt_cp","down",-0.548973347800428,1.9626829989744e-05,6.23466946078869e-05,-1.14902279651626,-0.962784837609452,22,2,"ABCC8; CYP2C9; CYP3A4; INS; KCNJ10; KCNJ11; PPARG","Insulin secretagogue","5311309",6
"minocycline","MCF7","trt_cp","up",0.573919994666191,1.85388682386495e-05,6.23466946078869e-05,1.13772460028588,0.76227548219154,22,2,"ALOX5; CASP1; CASP3; CYCS; IL1B; MMP9; VEGFA",NA,"44246707",6
"nateglinide","VCAP","trt_cp","down",-0.540012346936784,2.0018496220138e-05,6.23466946078869e-05,-1.12462706441856,-0.962784837609452,22,2,"ABCC8; CYP2C9; CYP3A4; INS; KCNJ10; KCNJ11; PPARG","Insulin secretagogue","5311309",6
"miglitol","PC3","trt_cp","up",0.550060995305085,1.95833115197002e-05,6.23466946078869e-05,1.11654110875172,0.956246171447883,22,2,"AMY2A; GAA; GANAB; GANC; MGAM; SI; SLC5A4","Glucosidase inhibitor","441314",6
"chlorprothixene","ASC","trt_cp","up",0.526078719893248,2.06277548007509e-05,6.23466946078869e-05,1.11081273249968,0.899894023238087,22,2,"CHRM1; CHRM4; CHRM5; DRD1; DRD3; HRH1; HTR2B","Dopamine receptor antagonist","667467",6
"VX-702","MCF7","trt_cp","up",0.559657879559238,1.91481268192624e-05,6.23466946078869e-05,1.10945174107189,1.06336946195339,22,2,"IL1B; IL6; MAPK11; MAPK12; MAPK14; NLK; TNF","p38 MAPK inhibitor","10341154",6
"cefotaxime","MCF7","trt_cp","down",-0.539338643570543,2.00620146901818e-05,6.23466946078869e-05,-1.10535582189453,-0.0110535582189453,22,2,"ALB; SLC15A1; SLC15A2; SLC22A11; SLC22A6; SLC22A7; SLC22A8","Bacterial cell wall synthesis inhibitor","5361298",6
"prostaglandin","NPC","trt_cp","down",-0.535794613714999,2.01925701003131e-05,6.23466946078869e-05,-1.09855745627399,-1.04782269381065,22,2,"AKR1C3; PTGDR; PTGDR2; PTGER1; PTGER2; PTGER4; PTGFR","Prostanoid receptor antagonist","13292831",6
"clenbuterol","PC3","trt_cp","down",-0.52224828691989,2.0801828680926e-05,6.23466946078869e-05,-1.07973294536424,-0.953656610376959,22,2,"ADRB1; ADRB2; ADRB3; MYOD1; NGF; SLC5A7; TNF",NA,"5702273",6
"doxazosin","PC3","trt_cp","up",0.517783653162946,2.09759025611011e-05,6.23466946078869e-05,1.05102295769112,1.00353520939036,22,2,"ADRA1A; ADRA1B; ADRA1D; KCNH2; KCNH6; KCNH7; LPL","Adrenergic receptor antagonist","3157",6
"hydroflumethiazide","HEK293T","trt_cp","down",-0.528345207928658,2.05407178606633e-05,6.23466946078869e-05,-1.03180831484629,-1.12679005110042,22,2,"ATP1A1; CA1; CA12; CA4; CA9; KCNMA1; SLC12A1","Sodium/potassium/chloride transporter inhibitor","3647",6
"prostaglandin","PC3","trt_cp","down",-0.493010358540977,2.20638643121956e-05,6.23466946078869e-05,-1.01928438992502,-1.04782269381065,22,2,"AKR1C3; PTGDR; PTGDR2; PTGER1; PTGER2; PTGER4; PTGFR","Prostanoid receptor antagonist","13292831",6
"nateglinide","HA1E","trt_cp","down",-0.480204843801175,2.26296044227647e-05,6.23466946078869e-05,-1.01292718048249,-0.962784837609452,22,2,"ABCC8; CYP2C9; CYP3A4; INS; KCNJ10; KCNJ11; PPARG","Insulin secretagogue","5311309",6
"picrotoxin","SKB","trt_cp","up",0.493556962171432,2.20203458421518e-05,6.23466946078869e-05,0.981417933236797,0.0294425379971042,22,2,"GABRR1; GLRA1; GLRA2; GLRA3; GLRB; HTR3A; HTR3B","GABA receptor antagonist","73707459",6
"doxazosin","VCAP","trt_cp","up",0.48008439199103,2.26296044227647e-05,6.23466946078869e-05,0.979071823902098,1.00353520939036,22,2,"ADRA1A; ADRA1B; ADRA1D; KCNH2; KCNH6; KCNH7; LPL","Adrenergic receptor antagonist","3157",6
"prostaglandin","VCAP","trt_cp","down",-0.464972206680661,2.32823814734214e-05,6.23466946078869e-05,-0.968348836469669,-1.04782269381065,22,2,"AKR1C3; PTGDR; PTGDR2; PTGER1; PTGER2; PTGER4; PTGFR","Prostanoid receptor antagonist","13292831",6
"orlistat","A549","trt_cp","up",0.493786556198837,2.20203458421518e-05,6.23466946078869e-05,0.963870077089502,0.96604122264037,22,2,"CNR1; DAGLA; DAGLB; FASN; LIPF; LPL; PNLIP","Lipase inhibitor","3034010",6
"nateglinide","SKB","trt_cp","down",-0.446498540231745,2.41092324042532e-05,6.23466946078869e-05,-0.961234043499977,-0.962784837609452,22,2,"ABCC8; CYP2C9; CYP3A4; INS; KCNJ10; KCNJ11; PPARG","Insulin secretagogue","5311309",6
"VX-702","ASC","trt_cp","up",0.455032619846595,2.37175661738592e-05,6.23466946078869e-05,0.960799227786385,1.06336946195339,22,2,"IL1B; IL6; MAPK11; MAPK12; MAPK14; NLK; TNF","p38 MAPK inhibitor","10341154",6
"miglitol","MCF7","trt_cp","up",0.481557259297161,2.25425674826771e-05,6.23466946078869e-05,0.954627030667036,0.956246171447883,22,2,"AMY2A; GAA; GANAB; GANC; MGAM; SI; SLC5A4","Glucosidase inhibitor","441314",6
"chlorprothixene","SKB","trt_cp","up",0.47344608929838,2.29342337130712e-05,6.23466946078869e-05,0.94142828097088,0.899894023238087,22,2,"CHRM1; CHRM4; CHRM5; DRD1; DRD3; HRH1; HTR2B","Dopamine receptor antagonist","667467",6
"prostaglandin","ASC","trt_cp","down",-0.453970716635448,2.37610846439029e-05,6.23466946078869e-05,-0.911236832436366,-1.04782269381065,22,2,"AKR1C3; PTGDR; PTGDR2; PTGER1; PTGER2; PTGER4; PTGFR","Prostanoid receptor antagonist","13292831",6
"chlorprothixene","NPC","trt_cp","up",0.458388464613096,2.35870107637278e-05,6.23466946078869e-05,0.898609458565939,0.899894023238087,22,2,"CHRM1; CHRM4; CHRM5; DRD1; DRD3; HRH1; HTR2B","Dopamine receptor antagonist","667467",6
"furosemide","PC3","trt_cp","up",0.430431721793586,2.48055279249536e-05,6.23466946078869e-05,0.873711671969697,0.585386820219697,22,2,"ATP1A1; BSND; SERPINA7; SERPINE1; SLC12A1; SLC12A2; SLC12A4",NA,"3440",6
"orlistat","PC3","trt_cp","up",0.424784490386,2.50231202751725e-05,6.23466946078869e-05,0.862248641376687,0.96604122264037,22,2,"CNR1; DAGLA; DAGLB; FASN; LIPF; LPL; PNLIP","Lipase inhibitor","3034010",6
"prostaglandin","MCF7","trt_cp","down",-0.349321499960586,2.9440244984616e-05,6.45001858558835e-05,-0.71592228425935,-1.04782269381065,22,2,"AKR1C3; PTGDR; PTGDR2; PTGER1; PTGER2; PTGER4; PTGFR","Prostanoid receptor antagonist","13292831",6
"leucovorin","PC3","trt_cp","up",0.349832221849541,2.9048578754222e-05,6.38124514927833e-05,0.710106806690265,0.475771560482477,22,2,"AMT; FPGS; FTCD; MTHFR; MTHFS; SLC19A1; ST20-MTHFS",NA,"6006",6
"clenbuterol","MCF7","trt_cp","down",-0.340422184089302,3.3356907288556e-05,7.18648929423319e-05,-0.697683445402785,-0.953656610376959,22,2,"ADRB1; ADRB2; ADRB3; MYOD1; NGF; SLC5A7; TNF",NA,"5702273",6
"nomifensine","MCF7","trt_cp","down",-0.296159725155709,0.000722254288081566,0.00149224106744038,-0.606969072796892,-0.206369484750943,22,2,"MAOA; MAOB; MPO; SLC18A2; SLC6A2; SLC6A3; SLC6A4","Dopamine uptake inhibitor; Noradrenaline uptake inhibitor","23615863",6
"linoleic-acid","HA1E","trt_cp","up",0.298721049171292,0.000548572074136847,0.0011350312115183,0.55442007076267,0,22,2,"FABP4; FFAR1; FFAR4; HNF4A; KCNB1; PPARG; TRPM8","Oxidative stress inducer","5280450",6
"brefeldin-a","MCF7","trt_cp","up",0.738508946749837,1.13583206814261e-05,6.23466946078869e-05,1.46400161008017,1.10346230846168,22,2,"ARF1; ARFGEF1; ARFGEF2; CYTH2; GBF1; SAR1A","Brefeldin A inhibited guanine nucleotide exchange protein inhibitor; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor inhibitor; Protein synthesis inhibitor","5287620",5
"lobelanidine","VCAP","trt_cp","down",-0.692244120211161,1.34036887734837e-05,6.23466946078869e-05,-1.44166420858748,-0.888203266549303,22,2,"CHRNA10; CHRNA4; CHRNA9; CHRNB2; OPRM1; SLC18A2","Acetylcholine receptor antagonist; Dopamine receptor modulator; Opioid receptor antagonist; Vesicular monoamine transporter ligand","96946",5
"gossypol","PC3","trt_cp","up",0.70990119868165,1.26203563126957e-05,6.23466946078869e-05,1.44099268671206,1.31701734456557,22,2,"BCL2; BCL2L1; BCL2L2; CTGF; EGF; MCL1","BCL inhibitor; MCL1 inhibitor","227456",5
"gossypol","HCC515","trt_cp","up",0.705965917844859,1.27944301928708e-05,6.23466946078869e-05,1.41854697382976,1.31701734456557,22,2,"BCL2; BCL2L1; BCL2L2; CTGF; EGF; MCL1","BCL inhibitor; MCL1 inhibitor","227456",5
"digoxin","A549","trt_cp","up",0.694280900751796,1.33166518333962e-05,6.23466946078869e-05,1.35523451768487,0.946510315205008,22,2,"ABCB1; ABCG2; ATP1A1; RORC; SLCO1B3; SLCO4C1","ATPase inhibitor","30322",5
"xanthinol","VCAP","trt_cp","down",-0.647357668995737,1.53620199254537e-05,6.23466946078869e-05,-1.34818390550011,-1.18992716148689,22,2,"GAPDH; IDH3A; MDH2; NNT; OGDH; RPL3","Vasodilator","9912",5
"gossypol","MCF7","trt_cp","up",0.663318175476536,1.46657244047533e-05,6.23466946078869e-05,1.31494531131529,1.31701734456557,22,2,"BCL2; BCL2L1; BCL2L2; CTGF; EGF; MCL1","BCL inhibitor; MCL1 inhibitor","227456",5
"gossypol","A549","trt_cp","up",0.670027119191755,1.43610951144468e-05,6.23466946078869e-05,1.30789119898063,1.31701734456557,22,2,"BCL2; BCL2L1; BCL2L2; CTGF; EGF; MCL1","BCL inhibitor; MCL1 inhibitor","227456",5
"W-7","MCF7","trt_cp","up",0.653379852039899,1.51009091051911e-05,6.23466946078869e-05,1.29524382824353,0,22,2,"CALM1; CALM2; KCNA5; KCNH2; TNNC1; TNNI3","Calmodulin antagonist; Potassium channel blocker","124887",5
"brefeldin-a","NPC","trt_cp","up",0.6596707387742,1.47962798148846e-05,6.23466946078869e-05,1.29319651597694,1.10346230846168,22,2,"ARF1; ARFGEF1; ARFGEF2; CYTH2; GBF1; SAR1A","Brefeldin A inhibited guanine nucleotide exchange protein inhibitor; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor inhibitor; Protein synthesis inhibitor","5287620",5
"BRL-15572","PHH","trt_cp","down",-0.619242886922216,1.65805370866795e-05,6.23466946078869e-05,-1.27253951168943,0,22,2,"HTR1B; HTR1D; HTR1E; HTR1F; HTR2B; HTR6","Serotonin receptor antagonist","3654103",5
"dabrafenib","HEK293T","trt_cp","up",0.635054865118064,1.58842415659791e-05,6.23466946078869e-05,1.26918403592745,1.17565132267518,22,2,"BRAF; LIMK1; NEK11; RAF1; SIK1; SIK1B",NA,"44462760",5
"tacrine","A549","trt_cp","up",0.634869339296758,1.58842415659791e-05,6.23466946078869e-05,1.23926330380553,0.0123926330380556,22,2,"ACHE; BCHE; CES1; CHAT; CRAT; HNMT","Acetylcholine release stimulant; Acetylcholinesterase inhibitor; Butyrylcholinesterase inhibitor; Potassium channel antagonist","1935",5
"spiroxatrine","PC3","trt_cp","down",-0.592870233863677,1.77120173078178e-05,6.23466946078869e-05,-1.22574173982232,-1.13515273188993,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; HTR2B","Serotonin receptor antagonist","5268",5
"memantine","VCAP","trt_cp","down",-0.581662137926861,1.81907204782993e-05,6.23466946078869e-05,-1.21136671479974,-0.0121136671479974,22,2,"CYP2E1; GRIN1; GRIN2A; GRIN2B; GRIN3A; HTR3A","Glutamate receptor antagonist","2842572",5
"xanthinol","MCF7","trt_cp","down",-0.57982373380471,1.82777574183869e-05,6.23466946078869e-05,-1.18832860851705,-1.18992716148689,22,2,"GAPDH; IDH3A; MDH2; NNT; OGDH; RPL3","Vasodilator","9912",5
"bicuculline","ASC","trt_cp","down",-0.582506328521032,1.81472020082555e-05,6.23466946078869e-05,-1.16924110350027,0,22,2,"GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; KCNN1","GABA receptor antagonist","6710622",5
"dorzolamide","MCF7","trt_cp","down",-0.56903017477907,1.87564605888684e-05,6.23466946078869e-05,-1.16620758409172,-0.78135908134145,22,2,"CA1; CA14; CA3; CA4; CA6; CA7",NA,"5284549",5
"lobelanidine","PC3","trt_cp","down",-0.55920459710326,1.91916452893062e-05,6.23466946078869e-05,-1.15613902776505,-0.888203266549303,22,2,"CHRNA10; CHRNA4; CHRNA9; CHRNB2; OPRM1; SLC18A2","Acetylcholine receptor antagonist; Dopamine receptor modulator; Opioid receptor antagonist; Vesicular monoamine transporter ligand","96946",5
"spiroxatrine","HA1E","trt_cp","down",-0.547695765112048,1.96703484597878e-05,6.23466946078869e-05,-1.1552901522727,-1.13515273188993,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; HTR2B","Serotonin receptor antagonist","5268",5
"quinine","A549","trt_cp","down",-0.544090702418989,1.98444223399629e-05,6.23466946078869e-05,-1.13880322780121,0,22,2,"ABCB1; CYP2D6; GP9; KCNB2; KCNN4; SLC29A4","Hemozoin biocrystallization inhibitor","3034034",5
"brefeldin-a","PC3","trt_cp","up",0.559459146272464,1.91916452893062e-05,6.23466946078869e-05,1.13561794203184,1.10346230846168,22,2,"ARF1; ARFGEF1; ARFGEF2; CYTH2; GBF1; SAR1A","Brefeldin A inhibited guanine nucleotide exchange protein inhibitor; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor inhibitor; Protein synthesis inhibitor","5287620",5
"spiroxatrine","VCAP","trt_cp","down",-0.544869123819485,1.98009038699191e-05,6.23466946078869e-05,-1.13474176412702,-1.13515273188993,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C; HTR2B","Serotonin receptor antagonist","5268",5
"W-7","FIBRNPC","trt_cp","up",0.562312274186698,1.90610898791749e-05,6.23466946078869e-05,1.11409283688267,0,22,2,"CALM1; CALM2; KCNA5; KCNH2; TNNC1; TNNI3","Calmodulin antagonist; Potassium channel blocker","124887",5
"brefeldin-a","A549","trt_cp","up",0.566540570733444,1.8843497528956e-05,6.23466946078869e-05,1.10588572477717,1.10346230846168,22,2,"ARF1; ARFGEF1; ARFGEF2; CYTH2; GBF1; SAR1A","Brefeldin A inhibited guanine nucleotide exchange protein inhibitor; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor inhibitor; Protein synthesis inhibitor","5287620",5
"brefeldin-a","HA1E","trt_cp","up",0.59149781254623,1.77990542479053e-05,6.23466946078869e-05,1.09780767039219,1.10346230846168,22,2,"ARF1; ARFGEF1; ARFGEF2; CYTH2; GBF1; SAR1A","Brefeldin A inhibited guanine nucleotide exchange protein inhibitor; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor inhibitor; Protein synthesis inhibitor","5287620",5
"lobelanidine","PHH","trt_cp","down",-0.526928273378436,2.05842363307071e-05,6.23466946078869e-05,-1.08283366973027,-0.888203266549303,22,2,"CHRNA10; CHRNA4; CHRNA9; CHRNB2; OPRM1; SLC18A2","Acetylcholine receptor antagonist; Dopamine receptor modulator; Opioid receptor antagonist; Vesicular monoamine transporter ligand","96946",5
"digoxin","SKB","trt_cp","up",0.543684447105647,1.98444223399629e-05,6.23466946078869e-05,1.08109439701528,0.946510315205008,22,2,"ABCB1; ABCG2; ATP1A1; RORC; SLCO1B3; SLCO4C1","ATPase inhibitor","30322",5
"acetylcholine","VCAP","trt_cp","up",0.527157848426683,2.05842363307071e-05,6.23466946078869e-05,1.07507222637028,0.365524556965894,22,2,"ACHE; CHRM1; CHRM4; CHRM5; CHRNA2; CHRNA7","Acetylcholine receptor agonist","93565",5
"amlexanox","PC3","trt_cp","down",-0.503473338869466,2.16286796117578e-05,6.23466946078869e-05,-1.04091629346653,-0.890376467866937,22,2,"FGF1; IL3; PPID; S100A12; S100A13; S100A9","Histamine receptor modulator","2161",5
"quinine","A375","trt_cp","down",-0.499098015509077,2.18027534919329e-05,6.23466946078869e-05,-1.03060719880536,0,22,2,"ABCB1; CYP2D6; GP9; KCNB2; KCNN4; SLC29A4","Hemozoin biocrystallization inhibitor","3034034",5
"gossypol","A375","trt_cp","up",0.522474705483779,2.0801828680926e-05,6.23466946078869e-05,1.02254044653894,1.31701734456557,22,2,"BCL2; BCL2L1; BCL2L2; CTGF; EGF; MCL1","BCL inhibitor; MCL1 inhibitor","227456",5
"cyclophosphamide","VCAP","trt_cp","down",-0.48955277702571,2.21944197223269e-05,6.23466946078869e-05,-1.01954021167747,-0.34664367197034,22,2,"BCL2; CYP2B6; CYP2C9; CYP3A5; LGALS1; NR1I2","DNA alkylating agent","22420",5
"W-7","VCAP","trt_cp","up",0.493968071055288,2.20203458421518e-05,6.23466946078869e-05,1.0073858437092,0,22,2,"CALM1; CALM2; KCNA5; KCNH2; TNNC1; TNNI3","Calmodulin antagonist; Potassium channel blocker","124887",5
"digoxin","HA1E","trt_cp","up",0.534444911822536,2.02796070404007e-05,6.23466946078869e-05,0.991918670121874,0.946510315205008,22,2,"ABCB1; ABCG2; ATP1A1; RORC; SLCO1B3; SLCO4C1","ATPase inhibitor","30322",5
"atenolol","MCF7","trt_cp","up",0.49878682091077,2.18027534919329e-05,6.23466946078869e-05,0.988782481395574,0.662484262535034,22,2,"ADCY10; ADRB1; ADRB2; LTF; PLA2G2E; TF","Adrenergic receptor antagonist","175540",5
"dabrafenib","A375","trt_cp","up",0.503677154049795,2.1585161141714e-05,6.23466946078869e-05,0.985751571526616,1.17565132267518,22,2,"BRAF; LIMK1; NEK11; RAF1; SIK1; SIK1B",NA,"44462760",5
"brefeldin-a","VCAP","trt_cp","up",0.474558767830854,2.28471967729836e-05,6.23466946078869e-05,0.967803007387849,1.10346230846168,22,2,"ARF1; ARFGEF1; ARFGEF2; CYTH2; GBF1; SAR1A","Brefeldin A inhibited guanine nucleotide exchange protein inhibitor; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor inhibitor; Protein synthesis inhibitor","5287620",5
"brefeldin-a","FIBRNPC","trt_cp","up",0.479073711172401,2.26731228928085e-05,6.23466946078869e-05,0.949174710311868,1.10346230846168,22,2,"ARF1; ARFGEF1; ARFGEF2; CYTH2; GBF1; SAR1A","Brefeldin A inhibited guanine nucleotide exchange protein inhibitor; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor inhibitor; Protein synthesis inhibitor","5287620",5
"trichlormethiazide","MCF7","trt_cp","down",-0.461723932200568,2.34129368835527e-05,6.23466946078869e-05,-0.946287166050578,-0.634012401253887,22,2,"ATP1A1; CA1; CA4; CA7; SLC12A1; SLC12A3",NA,"5560",5
"nisoldipine","PC3","trt_cp","up",0.463695338921427,2.33258999434652e-05,6.23466946078869e-05,0.941231812946811,0.927067511009373,22,2,"CACNA1C; CACNA1D; CACNA1S; CACNA2D1; CACNB2; CYP3A5","Calcium channel blocker","4499",5
"nisoldipine","MCF7","trt_cp","up",0.467582812176342,2.315182606329e-05,6.23466946078869e-05,0.92692443725243,0.927067511009373,22,2,"CACNA1C; CACNA1D; CACNA1S; CACNA2D1; CACNB2; CYP3A5","Calcium channel blocker","4499",5
"digoxin","PC3","trt_cp","up",0.453712482523722,2.37610846439029e-05,6.23466946078869e-05,0.92096811556427,0.946510315205008,22,2,"ABCB1; ABCG2; ATP1A1; RORC; SLCO1B3; SLCO4C1","ATPase inhibitor","30322",5
"nicotinamide","A549","trt_cp","up",0.469720438437023,2.30647891232025e-05,6.23466946078869e-05,0.916893077632709,0,22,2,"AOX1; BST1; CYP2E1; LDHA; PARP1; SIRT5","Protein synthesis stimulant","936",5
"methylprednisolone","MCF7","trt_cp","up",0.460710423134965,2.34564553535965e-05,6.23466946078869e-05,0.913300785614962,0.00913300785614983,22,2,"CRP; IL10; IL6; IL8; NR3C1; TAT","Glucocorticoid receptor agonist","6741",5
"brefeldin-a","HCC515","trt_cp","up",0.451732248189856,2.38481215839905e-05,6.23466946078869e-05,0.907697379509836,1.10346230846168,22,2,"ARF1; ARFGEF1; ARFGEF2; CYTH2; GBF1; SAR1A","Brefeldin A inhibited guanine nucleotide exchange protein inhibitor; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor inhibitor; Protein synthesis inhibitor","5287620",5
"capsaicin","FIBRNPC","trt_cp","up",0.457548016675134,2.35870107637278e-05,6.23466946078869e-05,0.906526482362345,0,22,2,"CFTR; ENOX2; FOS; NTRK1; PHB2; TRPV1","TRPV agonist","1548942",5
"amlexanox","MCF7","trt_cp","down",-0.433701353257273,2.46314540447785e-05,6.23466946078869e-05,-0.888855863567952,-0.890376467866937,22,2,"FGF1; IL3; PPID; S100A12; S100A13; S100A9","Histamine receptor modulator","2161",5
"lobelanidine","MCF7","trt_cp","down",-0.430445824069718,2.48055279249536e-05,6.23466946078869e-05,-0.882183769543706,-0.888203266549303,22,2,"CHRNA10; CHRNA4; CHRNA9; CHRNB2; OPRM1; SLC18A2","Acetylcholine receptor antagonist; Dopamine receptor modulator; Opioid receptor antagonist; Vesicular monoamine transporter ligand","96946",5
"lobelanidine","A549","trt_cp","down",-0.417281658245751,2.53712680355227e-05,6.23466946078869e-05,-0.873386913615301,-0.888203266549303,22,2,"CHRNA10; CHRNA4; CHRNA9; CHRNB2; OPRM1; SLC18A2","Acetylcholine receptor antagonist; Dopamine receptor modulator; Opioid receptor antagonist; Vesicular monoamine transporter ligand","96946",5
"gestrinone","MCF7","trt_cp","up",0.435543370508271,2.45444171046909e-05,6.23466946078869e-05,0.863410251818987,0.293559485618455,22,2,"AR; ESR1; GNRHR; NR3C1; PGR; SHBG","Progesterone receptor antagonist","73707430",5
"digoxin","PHH","trt_cp","up",0.39846806784824,2.61981189663545e-05,6.23466946078869e-05,0.831052962323322,0.946510315205008,22,2,"ABCB1; ABCG2; ATP1A1; RORC; SLCO1B3; SLCO4C1","ATPase inhibitor","30322",5
"lobelanidine","ASC","trt_cp","down",-0.408506375130786,2.5719415795873e-05,6.23466946078869e-05,-0.819978121194905,-0.888203266549303,22,2,"CHRNA10; CHRNA4; CHRNA9; CHRNB2; OPRM1; SLC18A2","Acetylcholine receptor antagonist; Dopamine receptor modulator; Opioid receptor antagonist; Vesicular monoamine transporter ligand","96946",5
"amlexanox","VCAP","trt_cp","down",-0.382677167891605,2.68508960170112e-05,6.23466946078869e-05,-0.796961592428781,-0.890376467866937,22,2,"FGF1; IL3; PPID; S100A12; S100A13; S100A9","Histamine receptor modulator","2161",5
"BRL-15572","VCAP","trt_cp","down",-0.352471253427449,2.8656912523828e-05,6.31755287318929e-05,-0.734054903156585,0,22,2,"HTR1B; HTR1D; HTR1E; HTR1F; HTR2B; HTR6","Serotonin receptor antagonist","3654103",5
"montelukast","VCAP","trt_cp","down",-0.346370338081031,3.01582997403383e-05,6.57286741376738e-05,-0.721349166787355,-0.00721349166787355,22,2,"ALOX5; CCL11; CYP2C8; CYSLTR1; IL4; IL5","Leukotriene receptor antagonist","5284590",5
"pyridoxine","MCF7","trt_cp","up",0.362449609211451,2.78083023579743e-05,6.23466946078869e-05,0.71851101302668,0.481402378727876,22,2,"DDC; GOT1; PDXK; PDXP; PHOSPHO2; PNPO",NA,"6019",5
"cotinine","A549","trt_cp","up",0.354424399485333,2.83958017035653e-05,6.28319833929919e-05,0.691835508613494,0.0069183550861351,22,2,"AOX1; CYP2A6; CYP2U1; UGT1A4; UGT2B10; UGT2B11","Nicotine metabolite","854019",5
"digoxin","NPC","trt_cp","up",0.344625522267552,3.03976513255791e-05,6.61092453891588e-05,0.675592380437055,0.946510315205008,22,2,"ABCB1; ABCG2; ATP1A1; RORC; SLCO1B3; SLCO4C1","ATPase inhibitor","30322",5
"fenretinide","MCF7","trt_cp","up",0.724220537396354,1.20110977320828e-05,6.23466946078869e-05,1.43567662581147,1.02586116367868,22,2,"CYP2C8; CYP3A5; RARA; RARG; RBP4","Apoptosis stimulant; Retinoid receptor agonist","5353342",4
"lestaurtinib","VCAP","trt_cp","up",0.697929884403976,1.3142577953221e-05,6.23466946078869e-05,1.42334034656963,1.17446856471907,22,2,"FLT3; JAK2; NTRK1; NTRK2; NTRK3","FLT3 inhibitor; Growth factor receptor inhibitor; JAK inhibitor","126565",4
"ZK-93423","MCF7","trt_cp","up",0.709806915325566,1.26203563126957e-05,6.23466946078869e-05,1.40710342299302,0.868474701327788,22,2,"GABRA2; GABRA3; GABRA5; GABRB2; GABRG2","Benzodiazepine receptor agonist","121926",4
"lestaurtinib","PC3","trt_cp","up",0.688611380896228,1.3534244183615e-05,6.23466946078869e-05,1.39777755792062,1.17446856471907,22,2,"FLT3; JAK2; NTRK1; NTRK2; NTRK3","FLT3 inhibitor; Growth factor receptor inhibitor; JAK inhibitor","126565",4
"ZK-93423","HUH7","trt_cp","up",0.743630020092882,1.11407283312072e-05,6.23466946078869e-05,1.39537629268546,0.868474701327788,22,2,"GABRA2; GABRA3; GABRA5; GABRB2; GABRG2","Benzodiazepine receptor agonist","121926",4
"mafenide","A549","trt_cp","down",-0.656513413868415,1.49268352250159e-05,6.23466946078869e-05,-1.37410838208444,-1.16655488263662,22,2,"CA12; CA14; CA4; CA6; CA9","Carbonic anhydrase inhibitor","67313",4
"thapsigargin","HA1E","trt_cp","up",0.726845611662236,1.18805423219515e-05,6.23466946078869e-05,1.34901037797386,1.01674695074182,22,2,"ATP2A1; ATP2A2; ATP2A3; ATP2C1; ATP2C2","ATPase inhibitor","5353993",4
"RX-821002","A375","trt_cp","down",-0.647664774019141,1.531850145541e-05,6.23466946078869e-05,-1.33738856452062,-0.0264364824898846,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C","Adrenergic receptor antagonist","108094",4
"RX-821002","PC3","trt_cp","down",-0.639343633618238,1.5710167685804e-05,6.23466946078869e-05,-1.32182412449423,-0.0264364824898846,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C","Adrenergic receptor antagonist","108094",4
"AS-601245","NPC","trt_cp","up",0.652614201876625,1.51009091051911e-05,6.23466946078869e-05,1.27936311638162,0.327159032494608,22,2,"GSK3B; MAPK10; MAPK8; MAPK9; PIM1","JNK inhibitor","10109823",4
"bimatoprost","MCF7","trt_cp","down",-0.618969931421516,1.65805370866795e-05,6.23466946078869e-05,-1.26855738121228,-1.18839071742613,22,2,"AKR1C3; PTGER1; PTGER3; PTGFR; PTGIR","Prostanoid receptor agonist","46780805",4
"daunorubicin","VCAP","trt_cp","up",0.611491168223957,1.69286848470297e-05,6.23466946078869e-05,1.2470594407165,0,22,2,"ABCB1; ABCG2; DCXR; TOP2A; TOP2B","RNA synthesis inhibitor; Topoisomerase inhibitor","2958",4
"thapsigargin","NEU","trt_cp","up",0.668636578005028,1.44046135844906e-05,6.23466946078869e-05,1.24241726846853,1.01674695074182,22,2,"ATP2A1; ATP2A2; ATP2A3; ATP2C1; ATP2C2","ATPase inhibitor","5353993",4
"tolazoline","A549","trt_cp","down",-0.591207717850109,1.77990542479053e-05,6.23466946078869e-05,-1.2374209932193,-0.81857307645001,22,2,"ADRA1A; ADRA2B; ADRA2C; HRH1; HRH2","Adrenergic receptor antagonist","5504",4
"lestaurtinib","NPC","trt_cp","up",0.627979824229882,1.61888708562855e-05,6.23466946078869e-05,1.23107070401052,1.17446856471907,22,2,"FLT3; JAK2; NTRK1; NTRK2; NTRK3","FLT3 inhibitor; Growth factor receptor inhibitor; JAK inhibitor","126565",4
"fenretinide","NKDBA","trt_cp","up",0.647003634449501,1.53620199254537e-05,6.23466946078869e-05,1.23002739637457,1.02586116367868,22,2,"CYP2C8; CYP3A5; RARA; RARG; RBP4","Apoptosis stimulant; Retinoid receptor agonist","5353342",4
"varenicline","SKB","trt_cp","up",0.617468107221529,1.66675740267671e-05,6.23466946078869e-05,1.22781020241895,0.396275187285881,22,2,"CHRNA3; CHRNA4; CHRNA6; CHRNA7; CHRNB2","Acetylcholine receptor agonist","5310966",4
"KU-0060648","MCF7","trt_cp","up",0.61434850727791,1.67981294368984e-05,6.23466946078869e-05,1.21786906951294,0.980939433613129,22,2,"PIK3CA; PIK3CB; PIK3CD; PIK3CG; PRKDC","DNA dependent protein kinase inhibitor; PI3K inhibitor","11964036",4
"daunorubicin","NPC","trt_cp","up",0.615549015918629,1.67110924968109e-05,6.23466946078869e-05,1.20670176197019,0,22,2,"ABCB1; ABCG2; DCXR; TOP2A; TOP2B","RNA synthesis inhibitor; Topoisomerase inhibitor","2958",4
"fenretinide","A549","trt_cp","up",0.615356134007875,1.67546109668546e-05,6.23466946078869e-05,1.20117357768815,1.02586116367868,22,2,"CYP2C8; CYP3A5; RARA; RARG; RBP4","Apoptosis stimulant; Retinoid receptor agonist","5353342",4
"purvalanol-b","VCAP","trt_cp","down",-0.57251471782699,1.85823867086933e-05,6.23466946078869e-05,-1.19231634257718,0,22,2,"CDK2; CDK4; CDK5; MAPK3; SRPK2","Tyrosine kinase inhibitor","448991",4
"fenretinide","NPC","trt_cp","up",0.608039104262537,1.70592402571611e-05,6.23466946078869e-05,1.19197958161853,1.02586116367868,22,2,"CYP2C8; CYP3A5; RARA; RARG; RBP4","Apoptosis stimulant; Retinoid receptor agonist","5353342",4
"itraconazole","A549","trt_cp","up",0.601207010973486,1.73638695474675e-05,6.23466946078869e-05,1.17355452622006,0,22,2,"ABCB1; CYP3A5; CYP3A7; CYP51A1; KDR","Cytochrome P450 inhibitor","3793",4
"lestaurtinib","MCF7","trt_cp","up",0.591572247301062,1.77555357778615e-05,6.23466946078869e-05,1.1727179830915,1.17446856471907,22,2,"FLT3; JAK2; NTRK1; NTRK2; NTRK3","FLT3 inhibitor; Growth factor receptor inhibitor; JAK inhibitor","126565",4
"prostratin","MCF7","trt_cp","down",-0.572023838194775,1.86259051787371e-05,6.23466946078869e-05,-1.17234299330963,-1.10772241451886,22,2,"PRKCA; PRKCB; PRKCE; PRKCG; PRKCH","PKC activator","454217",4
"mafenide","PC3","trt_cp","down",-0.56322852621603,1.90175714091311e-05,6.23466946078869e-05,-1.1644583826422,-1.16655488263662,22,2,"CA12; CA14; CA4; CA6; CA9","Carbonic anhydrase inhibitor","67313",4
"KU-0060648","A375","trt_cp","up",0.592505944905419,1.77120173078178e-05,6.23466946078869e-05,1.15959928226492,0.980939433613129,22,2,"PIK3CA; PIK3CB; PIK3CD; PIK3CG; PRKDC","DNA dependent protein kinase inhibitor; PI3K inhibitor","11964036",4
"selegiline","VCAP","trt_cp","up",0.562877752550133,1.90175714091311e-05,6.23466946078869e-05,1.14791848478479,0.0114791848478482,22,2,"CAT; CYP2B6; MAOA; MAOB; TH","Monoamine oxidase inhibitor","26758",4
"bimatoprost","PC3","trt_cp","down",-0.554829062604389,1.93657191694813e-05,6.23466946078869e-05,-1.14709273911206,-1.18839071742613,22,2,"AKR1C3; PTGER1; PTGER3; PTGFR; PTGIR","Prostanoid receptor agonist","46780805",4
"ZK-93423","PC3","trt_cp","up",0.564632643496642,1.89305344690436e-05,6.23466946078869e-05,1.14611936346712,0.868474701327788,22,2,"GABRA2; GABRA3; GABRA5; GABRB2; GABRG2","Benzodiazepine receptor agonist","121926",4
"AS-601245","SKBR3","trt_cp","up",0.548391939127287,1.96703484597878e-05,6.23466946078869e-05,1.14297368171257,0.327159032494608,22,2,"GSK3B; MAPK10; MAPK8; MAPK9; PIM1","JNK inhibitor","10109823",4
"sertraline","PHH","trt_cp","down",-0.549777574161415,1.95833115197002e-05,6.23466946078869e-05,-1.12978881233244,-0.730823262051687,22,2,"CYP2C9; PGRMC1; SIGMAR1; SLC6A3; SLC6A4","Serotonin receptor antagonist","6093397",4
"sertraline","A549","trt_cp","down",-0.538348159256512,2.01055331602256e-05,6.23466946078869e-05,-1.12678385922876,-0.730823262051687,22,2,"CYP2C9; PGRMC1; SIGMAR1; SLC6A3; SLC6A4","Serotonin receptor antagonist","6093397",4
"bendroflumethiazide","VCAP","trt_cp","up",0.552029289755249,1.94962745796127e-05,6.23466946078869e-05,1.12579440736776,0.934506576240515,22,2,"CA1; CA4; KCNMA1; SLC12A1; SLC12A3","Sodium/potassium/chloride transporter inhibitor","2315",4
"baclofen","MCF7","trt_cp","up",0.567208992357057,1.8843497528956e-05,6.23466946078869e-05,1.12442087765792,0.753361988030809,22,2,"ADCY10; GABBR1; GABBR2; KCNJ6; RXFP4",NA,"2284",4
"acyclovir","A549","trt_cp","down",-0.536140730488141,2.01925701003131e-05,6.23466946078869e-05,-1.12216362404483,-0.0112216362404483,22,2,"DCK; PNP; SLC22A6; SLC22A7; SLC22A8","DNA polymerase inhibitor","2022",4
"bendroflumethiazide","PC3","trt_cp","up",0.55253250563149,1.94527561095689e-05,6.23466946078869e-05,1.1215579030776,0.934506576240515,22,2,"CA1; CA4; KCNMA1; SLC12A1; SLC12A3","Sodium/potassium/chloride transporter inhibitor","2315",4
"enalaprilat","VCAP","trt_cp","up",0.547243437304852,1.97138669298316e-05,6.23466946078869e-05,1.11603426234804,0.939298159699256,22,2,"ACE; ACE2; AGT; ATP6AP2; BDKRB1","ACE inhibitor","5462501",4
"varenicline","NPC","trt_cp","up",0.566109271243958,1.88870159989998e-05,6.23466946078869e-05,1.1097817353477,0.396275187285881,22,2,"CHRNA3; CHRNA4; CHRNA6; CHRNA7; CHRNB2","Acetylcholine receptor agonist","5310966",4
"prostratin","A549","trt_cp","down",-0.528929235424251,2.04971993906196e-05,6.23466946078869e-05,-1.10706968139976,-1.10772241451886,22,2,"PRKCA; PRKCB; PRKCE; PRKCG; PRKCH","PKC activator","454217",4
"varenicline","NEU","trt_cp","up",0.592402702689371,1.77555357778615e-05,6.23466946078869e-05,1.10076440912745,0.396275187285881,22,2,"CHRNA3; CHRNA4; CHRNA6; CHRNA7; CHRNB2","Acetylcholine receptor agonist","5310966",4
"benzydamine","PC3","trt_cp","down",-0.523806004674438,2.07147917408385e-05,6.23466946078869e-05,-1.08295348092422,-0.90016779538429,22,2,"FMO1; FMO3; FMO4; FMO5; PRSS2","Membrane integrity inhibitor; Prostanoid receptor antagonist; Prostanoid receptor inhibitor","12555",4
"cirazoline","HA1E","trt_cp","down",-0.512900218499873,2.119349491132e-05,6.23466946078869e-05,-1.0818936520537,-0.0285535222373135,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C","Adrenergic receptor agonist","2765",4
"cirazoline","PHH","trt_cp","down",-0.521601614740066,2.0801828680926e-05,6.23466946078869e-05,-1.07188742597719,-0.0285535222373135,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C","Adrenergic receptor agonist","2765",4
"cinchocaine","MCF7","trt_cp","up",0.538487595962725,2.01055331602256e-05,6.23466946078869e-05,1.06748430193991,0.71521448229974,22,2,"CALM1; CALM2; CALM3; SCN10A; SCN5A",NA,"3025",4
"piribedil","MCF7","trt_cp","up",0.536842853033954,2.01490516302693e-05,6.23466946078869e-05,1.06422380481732,0.0208855927301846,22,2,"ADRA1A; ADRA2C; DRD3; DRD4; HTR2B","Dopamine receptor agonist","4850",4
"thapsigargin","A549","trt_cp","up",0.544575532271435,1.98009038699191e-05,6.23466946078869e-05,1.06301002666456,1.01674695074182,22,2,"ATP2A1; ATP2A2; ATP2A3; ATP2C1; ATP2C2","ATPase inhibitor","5353993",4
"benzydamine","MCF7","trt_cp","down",-0.518527939858629,2.09323840910573e-05,6.23466946078869e-05,-1.06270500727201,-0.90016779538429,22,2,"FMO1; FMO3; FMO4; FMO5; PRSS2","Membrane integrity inhibitor; Prostanoid receptor antagonist; Prostanoid receptor inhibitor","12555",4
"piribedil","PC3","trt_cp","up",0.514461573991914,2.11499764412762e-05,6.23466946078869e-05,1.0442796365092,0.0208855927301846,22,2,"ADRA1A; ADRA2C; DRD3; DRD4; HTR2B","Dopamine receptor agonist","4850",4
"celiprolol","MCF7","trt_cp","down",-0.506643742905665,2.14546057315827e-05,6.23466946078869e-05,-1.03834875828615,-1.03307557861421,22,2,"ADRA2B; ADRA2C; ADRB1; ADRB2; ADRB3",NA,"2663",4
"pranlukast","PC3","trt_cp","up",0.510212071194421,2.13240503214514e-05,6.23466946078869e-05,1.03565378482066,0.69388803582984,22,2,"CYSLTR1; IL5; NFKB1; RNASE3; TNF",NA,"4887",4
"mesulergine","A375","trt_cp","up",0.529118802133451,2.04971993906196e-05,6.23466946078869e-05,1.03554367422384,0,22,2,"HTR2B; HTR3A; HTR3B; HTR6; HTR7","Dopamine receptor agonist","68848",4
"bendroflumethiazide","MCF7","trt_cp","up",0.521823973683107,2.0801828680926e-05,6.23466946078869e-05,1.03445075515013,0.934506576240515,22,2,"CA1; CA4; KCNMA1; SLC12A1; SLC12A3","Sodium/potassium/chloride transporter inhibitor","2315",4
"celiprolol","PC3","trt_cp","down",-0.494502537495452,2.1976827372108e-05,6.23466946078869e-05,-1.02236942594693,-1.03307557861421,22,2,"ADRA2B; ADRA2C; ADRB1; ADRB2; ADRB3",NA,"2663",4
"WZ-4-145","NEU","trt_cp","up",0.548470309367684,1.96703484597878e-05,6.23466946078869e-05,1.01913207565435,0,22,2,"CSF1R; DDR1; EGFR; PDGFRA; TIE1","EGFR inhibitor","73707531",4
"fenretinide","PHH","trt_cp","up",0.488554758002728,2.22379381923707e-05,6.23466946078869e-05,1.01893956293119,1.02586116367868,22,2,"CYP2C8; CYP3A5; RARA; RARG; RBP4","Apoptosis stimulant; Retinoid receptor agonist","5353342",4
"thapsigargin","A375","trt_cp","up",0.518783388822993,2.09323840910573e-05,6.23466946078869e-05,1.01531613396071,1.01674695074182,22,2,"ATP2A1; ATP2A2; ATP2A3; ATP2C1; ATP2C2","ATPase inhibitor","5353993",4
"AS-601245","MCF10A","trt_cp","up",0.496363109319228,2.19333089020643e-05,6.23466946078869e-05,1.01244317200345,0.327159032494608,22,2,"GSK3B; MAPK10; MAPK8; MAPK9; PIM1","JNK inhibitor","10109823",4
"ZK-93423","HEPG2","trt_cp","up",0.53246006726264,2.03666439804882e-05,6.23466946078869e-05,0.992751546174491,0.868474701327788,22,2,"GABRA2; GABRA3; GABRA5; GABRB2; GABRG2","Benzodiazepine receptor agonist","121926",4
"KU-0060648","VCAP","trt_cp","up",0.484984723878828,2.24120120725458e-05,6.23466946078869e-05,0.98906543535698,0.980939433613129,22,2,"PIK3CA; PIK3CB; PIK3CD; PIK3CG; PRKDC","DNA dependent protein kinase inhibitor; PI3K inhibitor","11964036",4
"phenylpropanolamine","PC3","trt_cp","up",0.483764721787617,2.24555305425896e-05,6.23466946078869e-05,0.981969642366894,0.88554025077868,22,2,"ADRA2B; ADRA2C; ADRB1; ADRB2; DRD1",NA,"26934",4
"KU-0060648","HA1E","trt_cp","up",0.518784099066607,2.09323840910573e-05,6.23466946078869e-05,0.962852526505848,0.980939433613129,22,2,"PIK3CA; PIK3CB; PIK3CD; PIK3CG; PRKDC","DNA dependent protein kinase inhibitor; PI3K inhibitor","11964036",4
"hydroxyfasudil","VCAP","trt_cp","up",0.467974940196033,2.315182606329e-05,6.23466946078869e-05,0.95437611778632,0,22,2,"CLCN2; PKIA; PRKACA; ROCK1; ROCK2","Rho associated kinase inhibitor","3064778",4
"cirazoline","A549","trt_cp","down",-0.454737792311802,2.37175661738592e-05,6.23466946078869e-05,-0.951784074577124,-0.0285535222373135,22,2,"ADRA1A; ADRA1B; ADRA1D; ADRA2B; ADRA2C","Adrenergic receptor agonist","2765",4
"enalaprilat","PC3","trt_cp","up",0.461863249318589,2.34129368835527e-05,6.23466946078869e-05,0.937512946541187,0.939298159699256,22,2,"ACE; ACE2; AGT; ATP6AP2; BDKRB1","ACE inhibitor","5462501",4
"lestaurtinib","SKB","trt_cp","up",0.471241704570105,2.30212706531587e-05,6.23466946078869e-05,0.937044951649448,1.17446856471907,22,2,"FLT3; JAK2; NTRK1; NTRK2; NTRK3","FLT3 inhibitor; Growth factor receptor inhibitor; JAK inhibitor","126565",4
"bendroflumethiazide","SKB","trt_cp","up",0.468410652167521,2.315182606329e-05,6.23466946078869e-05,0.931415519160836,0.934506576240515,22,2,"CA1; CA4; KCNMA1; SLC12A1; SLC12A3","Sodium/potassium/chloride transporter inhibitor","2315",4
"benzydamine","NPC","trt_cp","down",-0.443805158049829,2.41962693443407e-05,6.23466946078869e-05,-0.909948426185251,-0.90016779538429,22,2,"FMO1; FMO3; FMO4; FMO5; PRSS2","Membrane integrity inhibitor; Prostanoid receptor antagonist; Prostanoid receptor inhibitor","12555",4
"lestaurtinib","A549","trt_cp","up",0.465814550543185,2.32388630033776e-05,6.23466946078869e-05,0.909268794593662,1.17446856471907,22,2,"FLT3; JAK2; NTRK1; NTRK2; NTRK3","FLT3 inhibitor; Growth factor receptor inhibitor; JAK inhibitor","126565",4
"benzydamine","SKB","trt_cp","down",-0.417992419544512,2.5327749565479e-05,6.23466946078869e-05,-0.899865301648178,-0.90016779538429,22,2,"FMO1; FMO3; FMO4; FMO5; PRSS2","Membrane integrity inhibitor; Prostanoid receptor antagonist; Prostanoid receptor inhibitor","12555",4
"AS-601245","PC3","trt_cp","up",0.43560546924901,2.45444171046909e-05,6.23466946078869e-05,0.884213601336777,0.327159032494608,22,2,"GSK3B; MAPK10; MAPK8; MAPK9; PIM1","JNK inhibitor","10109823",4
"bendroflumethiazide","A549","trt_cp","up",0.452656411649074,2.38046031139467e-05,6.23466946078869e-05,0.88358414159733,0.934506576240515,22,2,"CA1; CA4; KCNMA1; SLC12A1; SLC12A3","Sodium/potassium/chloride transporter inhibitor","2315",4
"bendroflumethiazide","NPC","trt_cp","up",0.450133153383697,2.39351585240781e-05,6.23466946078869e-05,0.882426021750169,0.934506576240515,22,2,"CA1; CA4; KCNMA1; SLC12A1; SLC12A3","Sodium/potassium/chloride transporter inhibitor","2315",4
"loratadine","A549","trt_cp","up",0.449437802416697,2.39786769941218e-05,6.23466946078869e-05,0.87730142472303,0.0087730142472305,22,2,"CYP3A5; HRH1; ICAM1; KCNA5; KCNH2","Histamine receptor antagonist","3957",4
"tolazoline","HT29","trt_cp","down",-0.406491184831699,2.58499712060043e-05,6.23466946078869e-05,-0.836443488740622,-0.81857307645001,22,2,"ADRA1A; ADRA2B; ADRA2C; HRH1; HRH2","Adrenergic receptor antagonist","5504",4
"sertraline","PC3","trt_cp","down",-0.401281926527446,2.60675635562232e-05,6.23466946078869e-05,-0.829638559479616,-0.730823262051687,22,2,"CYP2C9; PGRMC1; SIGMAR1; SLC6A3; SLC6A4","Serotonin receptor antagonist","6093397",4
"fenretinide","PC3","trt_cp","up",0.404718493933074,2.58934896760481e-05,6.23466946078869e-05,0.821517685866321,1.02586116367868,22,2,"CYP2C8; CYP3A5; RARA; RARG; RBP4","Apoptosis stimulant; Retinoid receptor agonist","5353342",4
"tolazoline","PC3","trt_cp","down",-0.395753342141066,2.62851559064421e-05,6.23466946078869e-05,-0.818208374158365,-0.81857307645001,22,2,"ADRA1A; ADRA2B; ADRA2C; HRH1; HRH2","Adrenergic receptor antagonist","5504",4
"daunorubicin","NEU","trt_cp","up",0.436004275774374,2.45444171046909e-05,6.23466946078869e-05,0.810154961854515,0,22,2,"ABCB1; ABCG2; DCXR; TOP2A; TOP2B","RNA synthesis inhibitor; Topoisomerase inhibitor","2958",4
"WZ-4-145","PHH","trt_cp","up",0.3858680025731,2.67203406068799e-05,6.23466946078869e-05,0.8047740144796,0,22,2,"CSF1R; DDR1; EGFR; PDGFRA; TIE1","EGFR inhibitor","73707531",4
"CGP-54626","PC3","trt_cp","down",-0.388705247868022,2.65897851967485e-05,6.23466946078869e-05,-0.803636646918203,0,22,2,"GABBR1; GABBR2; KCTD12; KCTD16; KCTD8","GABA receptor antagonist","197584",4
"ZK-93423","HA1E","trt_cp","up",0.428607545191382,2.48490463949974e-05,6.23466946078869e-05,0.795486713084486,0.868474701327788,22,2,"GABRA2; GABRA3; GABRA5; GABRB2; GABRG2","Benzodiazepine receptor agonist","121926",4
"itraconazole","HT29","trt_cp","up",0.383537505839096,2.68073775469674e-05,6.23466946078869e-05,0.78979668239456,0,22,2,"ABCB1; CYP3A5; CYP3A7; CYP51A1; KDR","Cytochrome P450 inhibitor","3793",4
"benzydamine","HCC515","trt_cp","down",-0.375936126566285,2.71555253073176e-05,6.23466946078869e-05,-0.76615979005459,-0.90016779538429,22,2,"FMO1; FMO3; FMO4; FMO5; PRSS2","Membrane integrity inhibitor; Prostanoid receptor antagonist; Prostanoid receptor inhibitor","12555",4
"sertraline","ASC","trt_cp","down",-0.362567609999534,2.77647838879305e-05,6.23466946078869e-05,-0.727767118832266,-0.730823262051687,22,2,"CYP2C9; PGRMC1; SIGMAR1; SLC6A3; SLC6A4","Serotonin receptor antagonist","6093397",4
"phenylpropanolamine","MCF7","trt_cp","up",0.34794597118047,2.97013558048787e-05,6.4945306531332e-05,0.689759364826853,0.88554025077868,22,2,"ADRA2B; ADRA2C; ADRB1; ADRB2; DRD1",NA,"26934",4
"ZK-93423","ASC","trt_cp","up",0.317215286830903,0.00011184246801251,0.000234502804087185,0.66979858000492,0.868474701327788,22,2,"GABRA2; GABRA3; GABRA5; GABRB2; GABRG2","Benzodiazepine receptor agonist","121926",4
"prostratin","PC3","trt_cp","down",-0.317931748861416,0.000103269329413886,0.000216804262336434,-0.657314523035664,-1.10772241451886,22,2,"PRKCA; PRKCB; PRKCE; PRKCG; PRKCH","PKC activator","454217",4
"YM-976","HA1E","trt_cp","up",0.350916327764535,2.88745048740469e-05,6.35333115958871e-05,0.651293425122607,0,22,2,"PDE4A; PDE4B; PDE4C; PDE4D; TNF","Phosphodiesterase inhibitor","6604918",4
"QL-X-138","HS578T","trt_cp","up",0.801706039140768,8.6166570686681e-06,6.23466946078869e-05,1.45865488174852,1.06763375435148,22,2,"BTK; MKNK2; MTOR; PRKDC","MTOR inhibitor","73707530",3
"torasemide","A375","trt_cp","down",-0.66949197036874,1.44046135844906e-05,6.23466946078869e-05,-1.38246040409643,-0.0261601041105114,22,2,"CYP2C8; CYP2C9; SLC12A1; SLC12A2","Electrolyte reabsorption inhibitor; Thromboxane receptor antagonist","41781",3
"ataluren","PC3","trt_cp","up",0.67086947791927,1.43175766444031e-05,6.23466946078869e-05,1.36176416269656,1.13786840881094,22,2,"CFTR; DMD; F8; F9","CFTR channel agonist; Dystrophin stimulant","11219835",3
"NNC-55-0396","MCF7","trt_cp","up",0.675847196869774,1.40999842941842e-05,6.23466946078869e-05,1.33978252902694,0,22,2,"CATSPER1; CATSPER2; CATSPER3; CATSPER4","T-type calcium channel blocker","9957280",3
"QL-X-138","ASC","trt_cp","up",0.631689863035424,1.60147969761104e-05,6.23466946078869e-05,1.33381016246601,1.06763375435148,22,2,"BTK; MKNK2; MTOR; PRKDC","MTOR inhibitor","73707530",3
"QL-X-138","MDAMB231","trt_cp","up",0.653740496133401,1.50573906351473e-05,6.23466946078869e-05,1.31939684145707,1.06763375435148,22,2,"BTK; MKNK2; MTOR; PRKDC","MTOR inhibitor","73707530",3
"torasemide","MCF7","trt_cp","down",-0.638217793182875,1.57536861558477e-05,6.23466946078869e-05,-1.30800520552557,-0.0261601041105114,22,2,"CYP2C8; CYP2C9; SLC12A1; SLC12A2","Electrolyte reabsorption inhibitor; Thromboxane receptor antagonist","41781",3
"BI-2536","MDAMB231","trt_cp","up",0.647729343291192,1.531850145541e-05,6.23466946078869e-05,1.30726496937567,0.869902974015976,22,2,"BRD4; PLK1; PLK2; PLK3","PLK inhibitor","11364421",3
"GDC-0941","SKB","trt_cp","up",0.654396066435917,1.50573906351473e-05,6.23466946078869e-05,1.30123994647806,0,22,2,"PIK3CA; PIK3CB; PIK3CD; PIK3CG","PI3K inhibitor","17755052",3
"aminopurvalanol-a","HA1E","trt_cp","up",0.699282078827653,1.30990594831773e-05,6.23466946078869e-05,1.29785303279509,1.11072204679603,22,2,"CDK1; CDK2; CDK5; CDK6","CDK inhibitor; Tyrosine kinase inhibitor","6604931",3
"niguldipine","NEU","trt_cp","up",0.691397754835185,1.34472072435275e-05,6.23466946078869e-05,1.28471061596804,0,22,2,"ADRA1A; ADRA1B; ADRA1D; CACNA1C","Adrenergic receptor antagonist; Calcium channel blocker","71317558",3
"gliquidone","VCAP","trt_cp","up",0.62191589831585,1.64499816765482e-05,6.23466946078869e-05,1.26831936850217,0.797174787495681,22,2,"ABCC8; KCNJ10; KCNJ11; KCNJ8","Sulfonylurea","91610",3
"brimonidine","ASC","trt_cp","down",-0.627986713727581,1.61888708562855e-05,6.23466946078869e-05,-1.26053201860765,-0.02168235350758,22,2,"ADCY10; ADRA2B; ADRA2C; AOX1","Adrenergic receptor agonist","2435",3
"pirenzepine","PHH","trt_cp","down",-0.611637474535357,1.6885166376986e-05,6.23466946078869e-05,-1.2569104459878,-0.728261250472072,22,2,"ADCY10; CHRM1; CHRM4; CHRM5","Acetylcholine receptor antagonist","185248",3
"CP-55940","HCC515","trt_cp","down",-0.612676663575342,1.68416479069422e-05,6.23466946078869e-05,-1.24863824135153,-0.0301793078640001,22,2,"CNR1; CNR2; CXCR4; GPR55","Cannabinoid receptor agonist","104895",3
"mefloquine","VCAP","trt_cp","up",0.606345578433684,1.71462771972486e-05,6.23466946078869e-05,1.23656565657134,1.0742589823856,22,2,"ADORA2A; HBA1; HBA2; PANX1","Adenosine receptor antagonist; Hemoglobin antagonist","4046",3
"brimonidine","NPC","trt_cp","down",-0.602804890152428,1.727683260738e-05,6.23466946078869e-05,-1.23595084721703,-0.02168235350758,22,2,"ADCY10; ADRA2B; ADRA2C; AOX1","Adrenergic receptor agonist","2435",3
"ivermectin","PHH","trt_cp","up",0.591796490851608,1.77555357778615e-05,6.23466946078869e-05,1.23426258337491,1.14194886498968,22,2,"CHRNA7; GABRB3; GLRA3; P2RX7","GABA receptor agonist","45114068",3
"fludrocortisone","PC3","trt_cp","up",0.60680135843915,1.71027587272049e-05,6.23466946078869e-05,1.2317155139639,1.14712224196019,22,2,"AR; GPER1; NR3C1; NR3C2","Glucocorticoid receptor agonist; Mineralocorticoid receptor agonist","73707451",3
"flupentixol","HA1E","trt_cp","up",0.661619071280319,1.47092428747971e-05,6.23466946078869e-05,1.22795127204721,0,22,2,"ADRA1A; CHRM1; DRD1; DRD3","Dopamine receptor antagonist","5281881",3
"doxycycline","MCF7","trt_cp","down",-0.595030520450798,1.76249803677302e-05,6.23466946078869e-05,-1.2194943897047,-0.988114359794182,22,2,"B2M; MMP1; MMP8; PADI4","Bacterial 30S ribosomal subunit inhibitor; Metalloproteinase inhibitor","54416524",3
"niguldipine","SKB","trt_cp","up",0.605079453306816,1.71897956672924e-05,6.23466946078869e-05,1.20317586828441,0,22,2,"ADRA1A; ADRA1B; ADRA1D; CACNA1C","Adrenergic receptor antagonist; Calcium channel blocker","71317558",3
"rucaparib","HA1E","trt_cp","down",-0.570311489511409,1.87129421188247e-05,6.23466946078869e-05,-1.20299496459629,-0.796312380594407,22,2,"PARP1; PARP2; PARP3; TNKS2","PARP inhibitor","9931954",3
"aminopurvalanol-a","VCAP","trt_cp","up",0.588978165180994,1.78860911879929e-05,6.23466946078869e-05,1.2011469984074,1.11072204679603,22,2,"CDK1; CDK2; CDK5; CDK6","CDK inhibitor; Tyrosine kinase inhibitor","6604931",3
"GDC-0941","MCF10A","trt_cp","up",0.588733730298718,1.78860911879929e-05,6.23466946078869e-05,1.20085363754483,0,22,2,"PIK3CA; PIK3CB; PIK3CD; PIK3CG","PI3K inhibitor","17755052",3
"ivermectin","PC3","trt_cp","up",0.591583609858688,1.77555357778615e-05,6.23466946078869e-05,1.20082577261201,1.14194886498968,22,2,"CHRNA7; GABRB3; GLRA3; P2RX7","GABA receptor agonist","45114068",3
"CP-55940","PHH","trt_cp","down",-0.581458443174543,1.82342389483431e-05,6.23466946078869e-05,-1.19489276174434,-0.0301793078640001,22,2,"CNR1; CNR2; CXCR4; GPR55","Cannabinoid receptor agonist","104895",3
"fenbendazole","HCC515","trt_cp","down",-0.583973823010402,1.81036835382118e-05,6.23466946078869e-05,-1.19014170231958,-0.0200429132661732,22,2,"CYP2D6; CYP2J2; CYP3A4; TUBB","Tubulin inhibitor","3334",3
"navitoclax","PC3","trt_cp","down",-0.567628543403201,1.87999790589122e-05,6.23466946078869e-05,-1.17355528853188,-0.984007762214362,22,2,"BAD; BCL2; BCL2L1; BCL2L2","BCL inhibitor","24978538",3
"mecamylamine","PC3","trt_cp","down",-0.565947793890338,1.88870159989998e-05,6.23466946078869e-05,-1.17008038843667,-0.783953860252566,22,2,"CHRNA2; CHRNA4; CHRNA7; CHRNB2",NA,"4032",3
"ivermectin","HA1E","trt_cp","up",0.62672858488492,1.62323893263293e-05,6.23466946078869e-05,1.16319525304572,1.14194886498968,22,2,"CHRNA7; GABRB3; GLRA3; P2RX7","GABA receptor agonist","45114068",3
"linopirdine","HA1E","trt_cp","up",0.621373926636199,1.6493500146592e-05,6.23466946078869e-05,1.15325711841008,1.1079646680902,22,2,"KCNQ2; KCNQ3; KCNQ4; KCNQ5","Potassium channel blocker","3932",3
"LY-303511","ASC","trt_cp","up",0.543136524141015,1.98879408100067e-05,6.23466946078869e-05,1.14683020560855,0.846524089892407,22,2,"CSNK2A1; CSNK2A2; CSNK2B; MTOR","Casein kinase inhibitor; MTOR inhibitor; PI3K inhibitor","3971",3
"aminopurvalanol-a","ASC","trt_cp","up",0.538260524630607,2.01055331602256e-05,6.23466946078869e-05,1.13653455567061,1.11072204679603,22,2,"CDK1; CDK2; CDK5; CDK6","CDK inhibitor; Tyrosine kinase inhibitor","6604931",3
"aminopurvalanol-a","PC3","trt_cp","up",0.557563744933529,1.923516375935e-05,6.23466946078869e-05,1.13177056232201,1.11072204679603,22,2,"CDK1; CDK2; CDK5; CDK6","CDK inhibitor; Tyrosine kinase inhibitor","6604931",3
"pirenzepine","PC3","trt_cp","down",-0.547213470238557,1.97138669298316e-05,6.23466946078869e-05,-1.13134772628617,-0.728261250472072,22,2,"ADCY10; CHRM1; CHRM4; CHRM5","Acetylcholine receptor antagonist","185248",3
"ivermectin","A549","trt_cp","up",0.578893070204025,1.83212758884307e-05,6.23466946078869e-05,1.12999777170816,1.14194886498968,22,2,"CHRNA7; GABRB3; GLRA3; P2RX7","GABA receptor agonist","45114068",3
"linopirdine","A375","trt_cp","up",0.57564591411903,1.8451831298562e-05,6.23466946078869e-05,1.12660234819705,1.1079646680902,22,2,"KCNQ2; KCNQ3; KCNQ4; KCNQ5","Potassium channel blocker","3932",3
"QL-X-138","PC3","trt_cp","up",0.554967752493019,1.93657191694813e-05,6.23466946078869e-05,1.12650108802266,1.06763375435148,22,2,"BTK; MKNK2; MTOR; PRKDC","MTOR inhibitor","73707530",3
"rucaparib","MCF7","trt_cp","down",-0.545880555205932,1.97573853998753e-05,6.23466946078869e-05,-1.11876324262861,-0.796312380594407,22,2,"PARP1; PARP2; PARP3; TNKS2","PARP inhibitor","9931954",3
"ivermectin","MCF7","trt_cp","up",0.562066577879055,1.90610898791749e-05,6.23466946078869e-05,1.1142266841974,1.14194886498968,22,2,"CHRNA7; GABRB3; GLRA3; P2RX7","GABA receptor agonist","45114068",3
"rutin","SKB","trt_cp","up",0.560082359628643,1.91481268192624e-05,6.23466946078869e-05,1.1137009787296,0.0224064149401568,22,2,"AKR1B1; AKR1C3; CBR1; F10","Antioxidant; Capillary stabilizing agent; Nitric oxide scavenger","5293655",3
"aminopurvalanol-a","HCC515","trt_cp","up",0.552334731536803,1.94962745796127e-05,6.23466946078869e-05,1.10984502531578,1.11072204679603,22,2,"CDK1; CDK2; CDK5; CDK6","CDK inhibitor; Tyrosine kinase inhibitor","6604931",3
"linopirdine","MCF7","trt_cp","up",0.558715861080968,1.91916452893062e-05,6.23466946078869e-05,1.10758430727169,1.1079646680902,22,2,"KCNQ2; KCNQ3; KCNQ4; KCNQ5","Potassium channel blocker","3932",3
"salmeterol","HA1E","trt_cp","up",0.596722499874124,1.75379434276426e-05,6.23466946078869e-05,1.10750458169482,0.0209344216186458,22,2,"ADRB1; ADRB2; ADRB3; IL5","Adrenergic receptor agonist","5152",3
"ifosfamide","MCF7","trt_cp","down",-0.535025235643534,2.02360885703569e-05,6.23466946078869e-05,-1.09651564212777,-0.734665480225603,22,2,"AFP; CYP2B6; CYP2C9; NR1I2",NA,"3690",3
"navitoclax","MCF7","trt_cp","down",-0.534738672832107,2.02360885703569e-05,6.23466946078869e-05,-1.09592834159641,-0.984007762214362,22,2,"BAD; BCL2; BCL2L1; BCL2L2","BCL inhibitor","24978538",3
"ML-9","HT29","trt_cp","down",-0.530848458978186,2.0410162450532e-05,6.23466946078869e-05,-1.09233546406213,-0.8476191482931,22,2,"MLCK; PKA; PKC; TRPC6","Myosin light chain kinase inhibitor","108047",3
"BI-2536","HS578T","trt_cp","up",0.600281233162013,1.74073880175113e-05,6.23466946078869e-05,1.09217482272209,0.869902974015976,22,2,"BRD4; PLK1; PLK2; PLK3","PLK inhibitor","11364421",3
"QL-X-138","SKBR3","trt_cp","up",0.51937211745365,2.09323840910573e-05,6.23466946078869e-05,1.08248976491076,1.06763375435148,22,2,"BTK; MKNK2; MTOR; PRKDC","MTOR inhibitor","73707530",3
"gliquidone","NEU","trt_cp","up",0.581744631754483,1.81907204782993e-05,6.23466946078869e-05,1.08096027065573,0.797174787495681,22,2,"ABCC8; KCNJ10; KCNJ11; KCNJ8","Sulfonylurea","91610",3
"BI-2536","PC3","trt_cp","up",0.529382428797112,2.04971993906196e-05,6.23466946078869e-05,1.0745667281407,0.869902974015976,22,2,"BRD4; PLK1; PLK2; PLK3","PLK inhibitor","11364421",3
"GDC-0941","NPC","trt_cp","up",0.547036698965009,1.97138669298316e-05,6.23466946078869e-05,1.07239250073092,0,22,2,"PIK3CA; PIK3CB; PIK3CD; PIK3CG","PI3K inhibitor","17755052",3
"ML-9","A549","trt_cp","down",-0.512054825612535,2.12370133813638e-05,6.23466946078869e-05,-1.07175087834838,-0.8476191482931,22,2,"MLCK; PKA; PKC; TRPC6","Myosin light chain kinase inhibitor","108047",3
"MRS-1754","A549","trt_cp","down",-0.509186232989307,2.13675687914951e-05,6.23466946078869e-05,-1.06574680122658,0,22,2,"ADORA1; ADORA2A; ADORA2B; ADORA3","Adenosine receptor antagonist","6603931",3
"ebselen","A549","trt_cp","down",-0.503369202784055,2.16286796117578e-05,6.23466946078869e-05,-1.0535715283456,-0.718949764111778,22,2,"ALB; EPHX2; LTB4R; NOX3","Cyclooxygenase inhibitor; Glutathione peroxidase agonist; H+/K+-ATPase inhibitor; Nitric oxide synthase inhibitor","3194",3
"aminopurvalanol-a","NPC","trt_cp","up",0.536190391192763,2.01925701003131e-05,6.23466946078869e-05,1.05112976070345,1.11072204679603,22,2,"CDK1; CDK2; CDK5; CDK6","CDK inhibitor; Tyrosine kinase inhibitor","6604931",3
"PD-184352","ASC","trt_cp","up",0.494450228190649,2.20203458421518e-05,6.23466946078869e-05,1.0440293216441,0.902595076082017,22,2,"MAP2K1; MAP2K2; MAP3K1; MAP3K2","MEK inhibitor","6918454",3
"QL-X-138","A549","trt_cp","up",0.528311225635855,2.05407178606633e-05,6.23466946078869e-05,1.03126214229257,1.06763375435148,22,2,"BTK; MKNK2; MTOR; PRKDC","MTOR inhibitor","73707530",3
"L-741742","HA1E","trt_cp","up",0.55314550617946,1.94527561095689e-05,6.23466946078869e-05,1.02662658533385,0.988540091250869,22,2,"DRD3; DRD4; SCN1A; SCN3A","Dopamine receptor antagonist","133008",3
"hexamethyleneamiloride","MCF7","trt_cp","down",-0.500760069134949,2.17157165518454e-05,6.23466946078869e-05,-1.02629037319894,-0.294211739262409,22,2,"GNRH1; GNRHR; PLAU; SLC9A1","Sodium/hydrogen antiport inhibitor","1794",3
"aminophylline","MCF7","trt_cp","up",0.517506402865326,2.09759025611011e-05,6.23466946078869e-05,1.02589171106992,0.687347446416845,22,2,"ADORA1; ADORA3; HDAC2; PDE3A",NA,"18680317",3
"perospirone","A549","trt_cp","down",-0.489543185369348,2.21944197223269e-05,6.23466946078869e-05,-1.02463313041028,-0.90568544399811,22,2,"ADRA1B; ADRA1D; DRD3; DRD4","Dopamine receptor antagonist; Serotonin receptor antagonist","115367",3
"ataluren","VCAP","trt_cp","up",0.501393057940326,2.17157165518454e-05,6.23466946078869e-05,1.02252817196077,1.13786840881094,22,2,"CFTR; DMD; F8; F9","CFTR channel agonist; Dystrophin stimulant","11219835",3
"L-741742","A549","trt_cp","up",0.521026118485555,2.08453471509698e-05,6.23466946078869e-05,1.01704163202874,0.988540091250869,22,2,"DRD3; DRD4; SCN1A; SCN3A","Dopamine receptor antagonist","133008",3
"aminopurvalanol-a","HUH7","trt_cp","up",0.541268878449416,1.99749777500942e-05,6.23466946078869e-05,1.01565797580687,1.11072204679603,22,2,"CDK1; CDK2; CDK5; CDK6","CDK inhibitor; Tyrosine kinase inhibitor","6604931",3
"salmeterol","A549","trt_cp","up",0.519715216600152,2.08888656210136e-05,6.23466946078869e-05,1.01448275494819,0.0209344216186458,22,2,"ADRB1; ADRB2; ADRB3; IL5","Adrenergic receptor agonist","5152",3
"PD-184352","MCF10A","trt_cp","up",0.496588742850869,2.18897904320205e-05,6.23466946078869e-05,1.01290340187185,0.902595076082017,22,2,"MAP2K1; MAP2K2; MAP3K1; MAP3K2","MEK inhibitor","6918454",3
"navitoclax","HCC515","trt_cp","down",-0.495632991533396,2.19333089020643e-05,6.23466946078869e-05,-1.01010262622472,-0.984007762214362,22,2,"BAD; BCL2; BCL2L1; BCL2L2","BCL inhibitor","24978538",3
"LY-303511","PHH","trt_cp","up",0.483524915297306,2.24555305425896e-05,6.23466946078869e-05,1.00844922250583,0.846524089892407,22,2,"CSNK2A1; CSNK2A2; CSNK2B; MTOR","Casein kinase inhibitor; MTOR inhibitor; PI3K inhibitor","3971",3
"tizanidine","MCF7","trt_cp","up",0.50754787875875,2.14110872615389e-05,6.23466946078869e-05,1.00615018269682,0.888811172258238,22,2,"ADRA2B; ADRA2C; CYP1A2; NISCH","Adrenergic receptor agonist","114869",3
"CP-55940","MCF7","trt_cp","down",-0.490848486519328,2.21509012522831e-05,6.23466946078869e-05,-1.00597692880001,-0.0301793078640001,22,2,"CNR1; CNR2; CXCR4; GPR55","Cannabinoid receptor agonist","104895",3
"LY-303511","HCC515","trt_cp","up",0.493225873793255,2.20638643121956e-05,6.23466946078869e-05,0.991073439947164,0.846524089892407,22,2,"CSNK2A1; CSNK2A2; CSNK2B; MTOR","Casein kinase inhibitor; MTOR inhibitor; PI3K inhibitor","3971",3
"mefloquine","PC3","trt_cp","up",0.488039329500949,2.22814566624145e-05,6.23466946078869e-05,0.990646453259611,1.0742589823856,22,2,"ADORA2A; HBA1; HBA2; PANX1","Adenosine receptor antagonist; Hemoglobin antagonist","4046",3
"L-741742","MCF7","trt_cp","up",0.498371130500124,2.18462719619767e-05,6.23466946078869e-05,0.987958427153361,0.988540091250869,22,2,"DRD3; DRD4; SCN1A; SCN3A","Dopamine receptor antagonist","133008",3
"PD-184352","NPC","trt_cp","up",0.503954380958818,2.1585161141714e-05,6.23466946078869e-05,0.987935361326275,0.902595076082017,22,2,"MAP2K1; MAP2K2; MAP3K1; MAP3K2","MEK inhibitor","6918454",3
"QL-X-138","NEU","trt_cp","up",0.530536581012583,2.0410162450532e-05,6.23466946078869e-05,0.985808780864107,1.06763375435148,22,2,"BTK; MKNK2; MTOR; PRKDC","MTOR inhibitor","73707530",3
"fludrocortisone","MCF7","trt_cp","up",0.492022098541404,2.21073827822394e-05,6.23466946078869e-05,0.975372265467814,1.14712224196019,22,2,"AR; GPER1; NR3C1; NR3C2","Glucocorticoid receptor agonist; Mineralocorticoid receptor agonist","73707451",3
"prenylamine","PC3","trt_cp","down",-0.471692887527901,2.29777521831149e-05,6.23466946078869e-05,-0.97521114671648,-0.653391468300041,22,2,"CALM1; CALM2; CALM3; MYLK2",NA,"65557",3
"efavirenz","PC3","trt_cp","up",0.477652581581572,2.27166413628523e-05,6.23466946078869e-05,0.969562916820541,0.00969562916820563,22,2,"CYP2B6; CYP2C8; CYP3A4; CYP3A5","HIV protease inhibitor","64139",3
"ciprofloxacin","PC3","trt_cp","up",0.475755027649432,2.28036783029398e-05,6.23466946078869e-05,0.96571116767019,0.932399286481921,22,2,"KCNH2; LPA; TOP2A; TOP2B",NA,"2764",3
"noreleagnine","VCAP","trt_cp","up",0.472265355154781,2.29777521831149e-05,6.23466946078869e-05,0.963125880263573,0.846983635747392,22,2,"ADRA2B; ADRA2C; MAOA; MAOB","Monoamine oxidase inhibitor; Serotonin receptor agonist","107838",3
"pirenzepine","VCAP","trt_cp","down",-0.460444051408512,2.34999738236403e-05,6.23466946078869e-05,-0.958918522515117,-0.728261250472072,22,2,"ADCY10; CHRM1; CHRM4; CHRM5","Acetylcholine receptor antagonist","185248",3
"gliquidone","HA1E","trt_cp","up",0.510602577861422,2.12805318514076e-05,6.23466946078869e-05,0.947667792861839,0.797174787495681,22,2,"ABCC8; KCNJ10; KCNJ11; KCNJ8","Sulfonylurea","91610",3
"PD-184352","A549","trt_cp","up",0.483134575744583,2.24990490126334e-05,6.23466946078869e-05,0.943077438868174,0.902595076082017,22,2,"MAP2K1; MAP2K2; MAP3K1; MAP3K2","MEK inhibitor","6918454",3
"serotonin","NEU","trt_cp","up",0.505394787296037,2.15416426716702e-05,6.23466946078869e-05,0.939091924949779,0.319291254482925,22,2,"HTR3A; HTR3B; SLC18A2; SLC6A4",NA,"73707588",3
"BI-2536","HCC515","trt_cp","up",0.466990947432112,2.31953445333338e-05,6.23466946078869e-05,0.938357757139339,0.869902974015976,22,2,"BRD4; PLK1; PLK2; PLK3","PLK inhibitor","11364421",3
"rutin","HCC515","trt_cp","up",0.465692644605513,2.32388630033776e-05,6.23466946078869e-05,0.935748985951899,0.0224064149401568,22,2,"AKR1B1; AKR1C3; CBR1; F10","Antioxidant; Capillary stabilizing agent; Nitric oxide scavenger","5293655",3
"noreleagnine","HA1E","trt_cp","up",0.499245492183442,2.18027534919329e-05,6.23466946078869e-05,0.926589277428422,0.846983635747392,22,2,"ADRA2B; ADRA2C; MAOA; MAOB","Monoamine oxidase inhibitor; Serotonin receptor agonist","107838",3
"navitoclax","A375","trt_cp","down",-0.448403283750317,2.40221954641656e-05,6.23466946078869e-05,-0.925925645546138,-0.984007762214362,22,2,"BAD; BCL2; BCL2L1; BCL2L2","BCL inhibitor","24978538",3
"PD-184352","SKB","trt_cp","up",0.460650660856925,2.34564553535965e-05,6.23466946078869e-05,0.915985092244205,0.902595076082017,22,2,"MAP2K1; MAP2K2; MAP3K1; MAP3K2","MEK inhibitor","6918454",3
"perospirone","MCF7","trt_cp","down",-0.44132680016421,2.43268247544721e-05,6.23466946078869e-05,-0.904483952216169,-0.90568544399811,22,2,"ADRA1B; ADRA1D; DRD3; DRD4","Dopamine receptor antagonist; Serotonin receptor antagonist","115367",3
"alfacalcidol","VCAP","trt_cp","up",0.441831392535098,2.42833062844283e-05,6.23466946078869e-05,0.901059635687186,0.306360276133643,22,2,"CYP27B1; CYP3A5; RXRA; VDR","Vitamin D receptor agonist","73707490",3
"tegafur","A549","trt_cp","down",-0.423639225205931,2.50666387452163e-05,6.23466946078869e-05,-0.886693551172285,-0.832659851445945,22,2,"CEACAM5; DPYD; TYMP; TYMS","Thymidylate synthase inhibitor","5386",3
"PSB-36","MCF7","trt_cp","up",0.441019227595168,2.43268247544721e-05,6.23466946078869e-05,0.874265453542768,0.0151312689728226,22,2,"ADORA1; ADORA2A; ADORA2B; ADORA3","Adenosine receptor antagonist","11689583",3
"PD-184352","BT20","trt_cp","up",0.432043675265032,2.47184909848661e-05,6.23466946078869e-05,0.869812622719416,0.902595076082017,22,2,"MAP2K1; MAP2K2; MAP3K1; MAP3K2","MEK inhibitor","6918454",3
"doxycycline","VCAP","trt_cp","down",-0.417228768723295,2.53712680355227e-05,6.23466946078869e-05,-0.868918586809974,-0.988114359794182,22,2,"B2M; MMP1; MMP8; PADI4","Bacterial 30S ribosomal subunit inhibitor; Metalloproteinase inhibitor","54416524",3
"QL-X-138","VCAP","trt_cp","up",0.425562766800207,2.49796018051287e-05,6.23466946078869e-05,0.867881816669613,1.06763375435148,22,2,"BTK; MKNK2; MTOR; PRKDC","MTOR inhibitor","73707530",3
"BI-2536","VCAP","trt_cp","up",0.425155227468782,2.50231202751725e-05,6.23466946078869e-05,0.867050691385836,0.869902974015976,22,2,"BRD4; PLK1; PLK2; PLK3","PLK inhibitor","11364421",3
"ciprofloxacin","MCF7","trt_cp","up",0.436227308410968,2.45444171046909e-05,6.23466946078869e-05,0.864766073160285,0.932399286481921,22,2,"KCNH2; LPA; TOP2A; TOP2B",NA,"2764",3
"fenbendazole","PHH","trt_cp","down",-0.417610262090273,2.5327749565479e-05,6.23466946078869e-05,-0.858185972289744,-0.0200429132661732,22,2,"CYP2D6; CYP2J2; CYP3A4; TUBB","Tubulin inhibitor","3334",3
"NNC-55-0396","VCAP","trt_cp","up",0.420758536400945,2.51971941553476e-05,6.23466946078869e-05,0.85808419213126,0,22,2,"CATSPER1; CATSPER2; CATSPER3; CATSPER4","T-type calcium channel blocker","9957280",3
"GDC-0941","MDAMB231","trt_cp","up",0.420893961169261,2.51971941553476e-05,6.23466946078869e-05,0.849459634579162,0,22,2,"PIK3CA; PIK3CB; PIK3CD; PIK3CG","PI3K inhibitor","17755052",3
"BI-2536","A375","trt_cp","up",0.433720102887061,2.46314540447785e-05,6.23466946078869e-05,0.848837930380574,0.869902974015976,22,2,"BRD4; PLK1; PLK2; PLK3","PLK inhibitor","11364421",3
"BI-2536","HA1E","trt_cp","up",0.455009448160986,2.37175661738592e-05,6.23466946078869e-05,0.844488097330038,0.869902974015976,22,2,"BRD4; PLK1; PLK2; PLK3","PLK inhibitor","11364421",3
"hydrochlorothiazide","PC3","trt_cp","up",0.415423943755488,2.54583049756103e-05,6.23466946078869e-05,0.843248139245904,0.564976253294756,22,2,"CA1; CA4; KCNMA1; SLC12A3",NA,"3639",3
"ML-9","PC3","trt_cp","down",-0.407766406786826,2.57629342659167e-05,6.23466946078869e-05,-0.843045031353197,-0.8476191482931,22,2,"MLCK; PKA; PKC; TRPC6","Myosin light chain kinase inhibitor","108047",3
"navitoclax","A549","trt_cp","down",-0.402492750794013,2.60240450861794e-05,6.23466946078869e-05,-0.842433148982279,-0.984007762214362,22,2,"BAD; BCL2; BCL2L1; BCL2L2","BCL inhibitor","24978538",3
"aminopurvalanol-a","NEU","trt_cp","up",0.453186349966761,2.38046031139467e-05,6.23466946078869e-05,0.842081581466654,1.11072204679603,22,2,"CDK1; CDK2; CDK5; CDK6","CDK inhibitor; Tyrosine kinase inhibitor","6604931",3
"LY-303511","A549","trt_cp","up",0.431380435553583,2.47620094549098e-05,6.23466946078869e-05,0.842053491437105,0.846524089892407,22,2,"CSNK2A1; CSNK2A2; CSNK2B; MTOR","Casein kinase inhibitor; MTOR inhibitor; PI3K inhibitor","3971",3
"hexamethyleneamiloride","SKB","trt_cp","down",-0.39096210047909,2.6502748256661e-05,6.23466946078869e-05,-0.841673705145164,-0.294211739262409,22,2,"GNRH1; GNRHR; PLAU; SLC9A1","Sodium/hydrogen antiport inhibitor","1794",3
"niguldipine","A375","trt_cp","up",0.429993023561959,2.48055279249536e-05,6.23466946078869e-05,0.841543626336042,0,22,2,"ADRA1A; ADRA1B; ADRA1D; CACNA1C","Adrenergic receptor antagonist; Calcium channel blocker","71317558",3
"indatraline","VCAP","trt_cp","up",0.4090082602287,2.5719415795873e-05,6.23466946078869e-05,0.834120979589394,0.00834120979589413,22,2,"CDK5; SLC6A2; SLC6A3; SLC6A4","Norepinephrine transporter inhibitor","10314472",3
"rucaparib","A375","trt_cp","down",-0.403769858781723,2.59370081460919e-05,6.23466946078869e-05,-0.833760324004932,-0.796312380594407,22,2,"PARP1; PARP2; PARP3; TNKS2","PARP inhibitor","9931954",3
"tegafur","PC3","trt_cp","down",-0.402479281932142,2.60240450861794e-05,6.23466946078869e-05,-0.832114056499215,-0.832659851445945,22,2,"CEACAM5; DPYD; TYMP; TYMS","Thymidylate synthase inhibitor","5386",3
"tizanidine","VCAP","trt_cp","up",0.406185249252708,2.58499712060043e-05,6.23466946078869e-05,0.828363803244424,0.888811172258238,22,2,"ADRA2B; ADRA2C; CYP1A2; NISCH","Adrenergic receptor agonist","114869",3
"vigabatrin","MCF7","trt_cp","down",-0.401274700919488,2.60675635562232e-05,6.23466946078869e-05,-0.822398565591244,-0.551007038946133,22,2,"ABAT; GABBR1; GAD1; SLC6A1",NA,"5665",3
"hexamethyleneamiloride","PHH","trt_cp","down",-0.397692359590352,2.61981189663545e-05,6.23466946078869e-05,-0.817254831284468,-0.294211739262409,22,2,"GNRH1; GNRHR; PLAU; SLC9A1","Sodium/hydrogen antiport inhibitor","1794",3
"misoprostol","MCF7","trt_cp","up",0.409520499130257,2.56758973258292e-05,6.23466946078869e-05,0.811823164399143,0.543921520147426,22,2,"PTGER2; PTGER3; PTGER4; PTGIR",NA,"5282381",3
"noreleagnine","A549","trt_cp","up",0.411946786793496,2.55888603857416e-05,6.23466946078869e-05,0.804119059457607,0.846983635747392,22,2,"ADRA2B; ADRA2C; MAOA; MAOB","Monoamine oxidase inhibitor; Serotonin receptor agonist","107838",3
"flupentixol","NPC","trt_cp","up",0.4065381838498,2.58064527359605e-05,6.23466946078869e-05,0.796963897387769,0,22,2,"ADRA1A; CHRM1; DRD1; DRD3","Dopamine receptor antagonist","5281881",3
"gliquidone","HCC515","trt_cp","up",0.394412294384502,2.63721928465296e-05,6.23466946078869e-05,0.792520364649305,0.797174787495681,22,2,"ABCC8; KCNJ10; KCNJ11; KCNJ8","Sulfonylurea","91610",3
"PD-184352","HS578T","trt_cp","up",0.431139487025581,2.47620094549098e-05,6.23466946078869e-05,0.78443180762169,0.902595076082017,22,2,"MAP2K1; MAP2K2; MAP3K1; MAP3K2","MEK inhibitor","6918454",3
"PSB-36","A375","trt_cp","up",0.386571764810385,2.66768221368361e-05,6.23466946078869e-05,0.756563448641113,0.0151312689728226,22,2,"ADORA1; ADORA2A; ADORA2B; ADORA3","Adenosine receptor antagonist","11689583",3
"gliquidone","MCF7","trt_cp","up",0.379089786507022,2.70249698971863e-05,6.23466946078869e-05,0.751498083068213,0.797174787495681,22,2,"ABCC8; KCNJ10; KCNJ11; KCNJ8","Sulfonylurea","91610",3
"rutin","HA1E","trt_cp","up",0.402418559022915,2.60240450861794e-05,6.23466946078869e-05,0.746880498005219,0.0224064149401568,22,2,"AKR1B1; AKR1C3; CBR1; F10","Antioxidant; Capillary stabilizing agent; Nitric oxide scavenger","5293655",3
"aminopurvalanol-a","SKB","trt_cp","up",0.367306397989061,2.75471915377116e-05,6.23466946078869e-05,0.730373824316286,1.11072204679603,22,2,"CDK1; CDK2; CDK5; CDK6","CDK inhibitor; Tyrosine kinase inhibitor","6604931",3
"brimonidine","HA1E","trt_cp","down",-0.342636383607549,3.13550576665423e-05,6.79406398285452e-05,-0.722745116919338,-0.02168235350758,22,2,"ADCY10; ADRA2B; ADRA2C; AOX1","Adrenergic receptor agonist","2435",3
"pirenzepine","SKB","trt_cp","down",-0.33496772961882,3.9057826864291e-05,8.35361609985273e-05,-0.721127520408885,-0.728261250472072,22,2,"ADCY10; CHRM1; CHRM4; CHRM5","Acetylcholine receptor antagonist","185248",3
"ebselen","VCAP","trt_cp","down",-0.343595232870791,3.07457990859294e-05,6.67463717130223e-05,-0.715569746291234,-0.718949764111778,22,2,"ALB; EPHX2; LTB4R; NOX3","Cyclooxygenase inhibitor; Glutathione peroxidase agonist; H+/K+-ATPase inhibitor; Nitric oxide synthase inhibitor","3194",3
"rucaparib","VCAP","trt_cp","down",-0.342342353831966,3.18990385420895e-05,6.89794944118325e-05,-0.712960506551627,-0.796312380594407,22,2,"PARP1; PARP2; PARP3; TNKS2","PARP inhibitor","9931954",3
"ebselen","MCF7","trt_cp","down",-0.343778184691499,3.07457990859294e-05,6.67463717130223e-05,-0.704561452102548,-0.718949764111778,22,2,"ALB; EPHX2; LTB4R; NOX3","Cyclooxygenase inhibitor; Glutathione peroxidase agonist; H+/K+-ATPase inhibitor; Nitric oxide synthase inhibitor","3194",3
"salmeterol","ASC","trt_cp","up",0.330483360054748,4.80226316933093e-05,0.000101979024171606,0.697814053954856,0.0209344216186458,22,2,"ADRB1; ADRB2; ADRB3; IL5","Adrenergic receptor agonist","5152",3
"myricetin","VCAP","trt_cp","down",-0.333568835751323,4.07115287259546e-05,8.69274271305101e-05,-0.694688820839945,0,22,2,"AMY2A; AR; CYP3A4; PIK3CG","Androgen receptor agonist; Cytochrome P450 inhibitor","5281672",3
"luteolin","PC3","trt_cp","up",0.334336582687236,4.07115287259546e-05,8.69274271305101e-05,0.678652989243166,0.454697502792921,22,2,"CSNK2A2; TNKS2; TOP1; TTR",NA,"5280445",3
"fenbendazole","SKB","trt_cp","down",-0.310334809572943,0.000200206721436402,0.000417265310219106,-0.668097108872444,-0.0200429132661732,22,2,"CYP2D6; CYP2J2; CYP3A4; TUBB","Tubulin inhibitor","3334",3
"mercaptopurine","VCAP","trt_cp","down",-0.304231701970297,0.000347690816414767,0.000721441175688866,-0.63359144995618,-0.215421092985101,22,2,"HPRT1; IMPDH1; IMPDH2; PPAT","Immunosuppressant; Protein synthesis inhibitor; Purine antagonist","2724350",3
"mefloquine","MCF7","trt_cp","up",0.261736384474313,0.0114617205662501,0.0234021161517057,0.518859642761721,1.0742589823856,22,2,"ADORA2A; HBA1; HBA2; PANX1","Adenosine receptor antagonist; Hemoglobin antagonist","4046",3
"PD-198306","MCF7","trt_cp","up",0.778723681953427,9.617581879675e-06,6.23466946078869e-05,1.5437222923361,1.09655124776476,22,2,"MAP2K1; MAP2K2; MAPK3","MAP kinase inhibitor; MEK inhibitor","9956637",2
"oxindole-I","MCF7","trt_cp","up",0.736389941000296,1.14888760915575e-05,6.23466946078869e-05,1.45980094623886,0.92107579638716,22,2,"AKT1; KDR; RET","VEGFR inhibitor","5908088",2
"BVT-948","MCF7","trt_cp","up",0.735505063498047,1.14888760915575e-05,6.23466946078869e-05,1.4580467872761,1.23043136617979,22,2,"PTPN1; PTPN11; PTPN2","Tyrosine phosphatase inhibitor","6604934",2
"brucine","HCC515","trt_cp","down",-0.691609706035096,1.34036887734837e-05,6.23466946078869e-05,-1.40950419427737,0,22,2,"CHRM1; CHRM4; CHRM5","Glycine receptor antagonist","442021",2
"BVT-948","PC3","trt_cp","up",0.69097831288293,1.34472072435275e-05,6.23466946078869e-05,1.40258207394216,1.23043136617979,22,2,"PTPN1; PTPN11; PTPN2","Tyrosine phosphatase inhibitor","6604934",2
"PD-198306","A549","trt_cp","up",0.717290394807447,1.23157270223893e-05,6.23466946078869e-05,1.40014899040753,1.09655124776476,22,2,"MAP2K1; MAP2K2; MAPK3","MAP kinase inhibitor; MEK inhibitor","9956637",2
"pevonedistat","PC3","trt_cp","up",0.6851837682722,1.37083180637902e-05,6.23466946078869e-05,1.390820019698,0.964246857889862,22,2,"NAE1; NEDD8; UBA3",NA,"16720766",2
"artemether","VCAP","trt_cp","down",-0.664877433992092,1.45786874646657e-05,6.23466946078869e-05,-1.38467048212918,-0.470787963923922,22,2,"ATP1A1; CYP2B6; CYP3A5","Antimalarial","68911",2
"phenylbutazone","HA1E","trt_cp","down",-0.651844306602231,1.51444275752348e-05,6.23466946078869e-05,-1.37497741666584,-1.1517756858809,22,2,"CYP2C9; PTGIS; PTGR2","Cyclooxygenase inhibitor; Prostanoid receptor antagonist","4781",2
"withaferin-a","MCF7","trt_cp","up",0.688307521406444,1.35777626536588e-05,6.23466946078869e-05,1.36448356381343,1.13273208063155,22,2,"ACHE; BCHE; IKBKB","IKK inhibitor","73707417",2
"equol","A375","trt_cp","up",0.695610524353579,1.32296148933086e-05,6.23466946078869e-05,1.36138628095132,1.12970129866843,22,2,"ESR1; ESR2; SHBG","Estrogen receptor agonist","382975",2
"phenylbutazone","ASC","trt_cp","down",-0.669580048179983,1.43610951144468e-05,6.23466946078869e-05,-1.34402061588497,-1.1517756858809,22,2,"CYP2C9; PTGIS; PTGR2","Cyclooxygenase inhibitor; Prostanoid receptor antagonist","4781",2
"midodrine","SKB","trt_cp","down",-0.62269854461574,1.64064632065044e-05,6.23466946078869e-05,-1.34056214296215,-1.01998389408035,22,2,"ADRA1A; ADRA1B; ADRA1D","Adrenergic receptor agonist","4195",2
"SB-216641","HA1E","trt_cp","down",-0.634088636102313,1.59277600360228e-05,6.23466946078869e-05,-1.33752423082396,-0.0212395714905236,22,2,"HTR1B; HTR1D; HTR2B","Serotonin receptor antagonist","3292447",2
"MDL-28170","PC3","trt_cp","down",-0.645044895470842,1.54490568655413e-05,6.23466946078869e-05,-1.33361131538903,-0.030000463195481,22,2,"CAPN1; CTSB; CTSL","Calpain inhibitor","72430",2
"pitavastatin","A549","trt_cp","up",0.678103965874691,1.40129473540966e-05,6.23466946078869e-05,1.32365718275883,1.0615295506022,22,2,"APOA1; CYP2C8; HMGCR","HMGCR inhibitor","11251522",2
"prednisone","MCF7","trt_cp","down",-0.644424118313418,1.54925753355851e-05,6.23466946078869e-05,-1.32072485337094,-0.85402848116663,22,2,"HSD11B1; NR3C1; SERPINA6","Glucocorticoid receptor agonist","5865",2
"midodrine","HA1E","trt_cp","down",-0.624930053489529,1.63194262664169e-05,6.23466946078869e-05,-1.31820543930626,-1.01998389408035,22,2,"ADRA1A; ADRA1B; ADRA1D","Adrenergic receptor agonist","4195",2
"TW-37","PC3","trt_cp","up",0.648037638220433,1.531850145541e-05,6.23466946078869e-05,1.31541896129205,1.15017757570275,22,2,"BCL2; BCL2L1; MCL1","BCL inhibitor","11455910",2
"phenylbutazone","SKB","trt_cp","down",-0.61008911017399,1.69722033170735e-05,6.23466946078869e-05,-1.31341621400032,-1.1517756858809,22,2,"CYP2C9; PTGIS; PTGR2","Cyclooxygenase inhibitor; Prostanoid receptor antagonist","4781",2
"MDL-29951","ASC","trt_cp","down",-0.651199908147164,1.51879460452786e-05,6.23466946078869e-05,-1.30712691334095,-0.718335837997622,22,2,"FBP1; FBP2; GPR17","Glutamate receptor antagonist","446916",2
"MDL-28170","ASC","trt_cp","down",-0.640543171692613,1.56231307457164e-05,6.23466946078869e-05,-1.28573608257785,-0.030000463195481,22,2,"CAPN1; CTSB; CTSL","Calpain inhibitor","72430",2
"pentamidine","MCF7","trt_cp","up",0.644995839722652,1.54490568655413e-05,6.23466946078869e-05,1.27862357254398,0,22,2,"AOC1; S100B; TRDMT1",NA,"359323",2
"PD-198306","ASC","trt_cp","up",0.598961571932554,1.74509064875551e-05,6.23466946078869e-05,1.26470453037087,1.09655124776476,22,2,"MAP2K1; MAP2K2; MAPK3","MAP kinase inhibitor; MEK inhibitor","9956637",2
"lysergol","ASC","trt_cp","up",0.598840843446849,1.74509064875551e-05,6.23466946078869e-05,1.26444961274348,0,22,2,"HTR1B; HTR1D; HTR1E","Ergoline alkaloid","14987",2
"proxymetacaine","ASC","trt_cp","up",0.597918532560677,1.74944249575989e-05,6.23466946078869e-05,1.2625021576632,0,22,2,"SCN10A; SCN5A; SCN9A","Sodium channel blocker","517321",2
"pevonedistat","HT29","trt_cp","up",0.609115312521123,1.70157217871173e-05,6.23466946078869e-05,1.25431605957915,0.964246857889862,22,2,"NAE1; NEDD8; UBA3",NA,"16720766",2
"BNTX","MCF7","trt_cp","up",0.628828504383245,1.61453523862417e-05,6.23466946078869e-05,1.24657385253482,1.0382319331113,22,2,"OPRD1; OPRK1; OPRM1","Opioid receptor antagonist","6438353",2
"withaferin-a","VCAP","trt_cp","up",0.604265470101174,1.72333141373362e-05,6.23466946078869e-05,1.23232353686697,1.13273208063155,22,2,"ACHE; BCHE; IKBKB","IKK inhibitor","73707417",2
"linsitinib","HCC515","trt_cp","up",0.611783144163044,1.6885166376986e-05,6.23466946078869e-05,1.22929890219326,0.708572728445391,22,2,"IGF1R; INSR; INSRR","IGF-1 inhibitor","11640390",2
"TW-37","HT29","trt_cp","up",0.595476858018955,1.76249803677302e-05,6.23466946078869e-05,1.226231176211,1.15017757570275,22,2,"BCL2; BCL2L1; MCL1","BCL inhibitor","11455910",2
"temsirolimus","A549","trt_cp","up",0.627296876554461,1.62323893263293e-05,6.23466946078869e-05,1.22448187617137,0,22,2,"IFNAR1; MTOR; PTEN","MTOR inhibitor","6440033",2
"levetiracetam","A549","trt_cp","down",-0.584016770646473,1.81036835382118e-05,6.23466946078869e-05,-1.22237005805345,-0.0122237005805345,22,2,"CACNA1B; SCN1A; SV2A","Calcium channel blocker","5284583",2
"calyculin","HT29","trt_cp","up",0.590555378874277,1.77990542479053e-05,6.23466946078869e-05,1.21609665783466,0.971019006592505,22,2,"PPP1CA; PPP1CC; PPP2CA","Protein phosphatase inhibitor","5311365",2
"IRL-2500","MCF7","trt_cp","down",-0.593233856873838,1.77120173078178e-05,6.23466946078869e-05,-1.21581219009143,-0.868184738683125,22,2,"EDNRB; HBA2; HBB","Endothelin receptor antagonist","4574540",2
"solifenacin","MCF7","trt_cp","down",-0.592846278229716,1.77120173078178e-05,6.23466946078869e-05,-1.21501786111866,-0.839747542055972,22,2,"CHRM1; CHRM4; CHRM5","Acetylcholine receptor antagonist","154059",2
"equol","HT29","trt_cp","up",0.588824590592881,1.78860911879929e-05,6.23466946078869e-05,1.21253254527262,1.12970129866843,22,2,"ESR1; ESR2; SHBG","Estrogen receptor agonist","382975",2
"gabexate","NPC","trt_cp","down",-0.589070265699828,1.78860911879929e-05,6.23466946078869e-05,-1.20779029144565,0,22,2,"KLKB1; PLG; TPSAB1","Serine protease inhibitor","3447",2
"calcipotriol","VCAP","trt_cp","up",0.586326030728955,1.80166465981242e-05,6.23466946078869e-05,1.19573830327273,1.05455393671962,22,2,"BGLAP; GC; VDR","Vitamin D receptor agonist","5353464",2
"profenamine","A549","trt_cp","up",0.612165925522341,1.6885166376986e-05,6.23466946078869e-05,1.19494629899804,0.0152525123584246,22,2,"BCHE; CHRM1; GRIN3A","Butyrylcholinesterase inhibitor; Cholinergic receptor antagonist","3290",2
"lomerizine","VCAP","trt_cp","down",-0.572446866278352,1.86259051787371e-05,6.23466946078869e-05,-1.19217503527487,-1.09245461109729,22,2,"ABCB1; CACNA1B; SCN5A","Calcium channel blocker","13579832",2
"brucine","NEU","trt_cp","down",-0.595511101248252,1.75814618976864e-05,6.23466946078869e-05,-1.18847236864874,0,22,2,"CHRM1; CHRM4; CHRM5","Glycine receptor antagonist","442021",2
"goserelin","A549","trt_cp","up",0.606857952133021,1.71027587272049e-05,6.23466946078869e-05,1.18458514870804,0.0118458514870807,22,2,"GNRH1; GNRHR; LHCGR","Gonadotropin releasing factor hormone receptor agonist; Luteinizing hormone releasing hormone agonist","23581804",2
"CNQX","VCAP","trt_cp","down",-0.568531410848241,1.87564605888684e-05,6.23466946078869e-05,-1.18402072700543,0,22,2,"GRIA1; GRIA3; GRIA4","Glutamate receptor antagonist","3721046",2
"withaferin-a","A549","trt_cp","up",0.606025273993898,1.71462771972486e-05,6.23466946078869e-05,1.18295976313999,1.13273208063155,22,2,"ACHE; BCHE; IKBKB","IKK inhibitor","73707417",2
"dacarbazine","MCF7","trt_cp","up",0.594325232742937,1.7668498837774e-05,6.23466946078869e-05,1.17817543237112,1.1524392715817,22,2,"CYP2E1; PGD; POLA2",NA,"5351166",2
"prednisone","ASC","trt_cp","down",-0.582959418255332,1.81472020082555e-05,6.23466946078869e-05,-1.17015057197294,-0.85402848116663,22,2,"HSD11B1; NR3C1; SERPINA6","Glucocorticoid receptor agonist","5865",2
"latrunculin-b","SKB","trt_cp","up",0.588398301474996,1.79296096580367e-05,6.23466946078869e-05,1.17000607673133,0,22,2,"ACTA1; MKL1; SPIRE2","Actin polymerization inhibitor; Unidentified pharmacological activity","6436219",2
"equol","HCC515","trt_cp","up",0.581438747929714,1.82342389483431e-05,6.23466946078869e-05,1.16832577252591,1.12970129866843,22,2,"ESR1; ESR2; SHBG","Estrogen receptor agonist","382975",2
"MK-2206","HCC515","trt_cp","up",0.581402222344283,1.82342389483431e-05,6.23466946078869e-05,1.16825237909803,0,22,2,"AKT1; AKT2; AKT3","AKT inhibitor","24964624",2
"gabexate","PHH","trt_cp","down",-0.567988666520411,1.87999790589122e-05,6.23466946078869e-05,-1.16721247123474,0,22,2,"KLKB1; PLG; TPSAB1","Serine protease inhibitor","3447",2
"L-741626","A549","trt_cp","down",-0.55602732872425,1.93222006994376e-05,6.23466946078869e-05,-1.16378705587445,-0.682744899578111,22,2,"DRD3; DRD4; HTR2B","Dopamine receptor antagonist","133633",2
"isosorbide","MCF7","trt_cp","down",-0.564365649096213,1.89740529390873e-05,6.23466946078869e-05,-1.15664780067663,-0.77495402645334,22,2,"BCL2; BCL2L1; MCL1",NA,"13019152",2
"TW-37","MCF7","trt_cp","up",0.58232374350531,1.81907204782993e-05,6.23466946078869e-05,1.15438398117128,1.15017757570275,22,2,"BCL2; BCL2L1; MCL1","BCL inhibitor","11455910",2
"AKT-inhibitor-1-2","HS578T","trt_cp","up",0.633770644393238,1.59277600360228e-05,6.23466946078869e-05,1.15310674888253,0,22,2,"AKT1; AKT2; AKT3","AKT inhibitor","10196499",2
"taxifolin","PC3","trt_cp","up",0.567383336204101,1.8843497528956e-05,6.23466946078869e-05,1.15170285604637,0.011517028560464,22,2,"APOB; APP; HMGCR","Opioid receptor antagonist","439533",2
"phenylbutazone","PC3","trt_cp","down",-0.554676100413603,1.93657191694813e-05,6.23466946078869e-05,-1.14677649428958,-1.1517756858809,22,2,"CYP2C9; PTGIS; PTGR2","Cyclooxygenase inhibitor; Prostanoid receptor antagonist","4781",2
"phenanthridone","HA1E","trt_cp","down",-0.543627502963436,1.98444223399629e-05,6.23466946078869e-05,-1.14670870341634,-0.0290768399005847,22,2,"PARP1; PARP14; TNKS2","PARP inhibitor","1853",2
"argatroban","VCAP","trt_cp","up",0.560731525706247,1.91046083492187e-05,6.23466946078869e-05,1.14354152468027,0.954985277718957,22,2,"CYP3A5; F2; SELP","Thrombin inhibitor","92722",2
"rivaroxaban","NEU","trt_cp","down",-0.572869296913679,1.85823867086933e-05,6.23466946078869e-05,-1.14328570668461,-0.288583397449827,22,2,"CYP2J2; CYP3A5; F10","Coagulation inhibitor","9875401",2
"TW-37","A375","trt_cp","up",0.58290793997023,1.81472020082555e-05,6.23466946078869e-05,1.1408149312728,1.15017757570275,22,2,"BCL2; BCL2L1; MCL1","BCL inhibitor","11455910",2
"chlorthalidone","ASC","trt_cp","down",-0.567545605856569,1.87999790589122e-05,6.23466946078869e-05,-1.13921105743748,-0.0240453712737819,22,2,"CA5B; CA7; SLC12A1",NA,"2732",2
"BVT-948","A375","trt_cp","up",0.581334139767271,1.82342389483431e-05,6.23466946078869e-05,1.13773483123081,1.23043136617979,22,2,"PTPN1; PTPN11; PTPN2","Tyrosine phosphatase inhibitor","6604934",2
"isoeugenol","PC3","trt_cp","up",0.553457365183094,1.94527561095689e-05,6.23466946078869e-05,1.12343522889783,0.731892848033884,22,2,"EPX; LPO; MPO","Nitric oxide production inhibitor","5318562",2
"phenylbutazone","HCC515","trt_cp","down",-0.550268060542104,1.95833115197002e-05,6.23466946078869e-05,-1.12144918231036,-1.1517756858809,22,2,"CYP2C9; PTGIS; PTGR2","Cyclooxygenase inhibitor; Prostanoid receptor antagonist","4781",2
"ibrutinib","MCF7","trt_cp","up",0.558404906972271,1.923516375935e-05,6.23466946078869e-05,1.10696787964709,0,22,2,"BLK; BMX; BTK",NA,"16126651",2
"calcipotriol","A549","trt_cp","up",0.565921245606061,1.88870159989998e-05,6.23466946078869e-05,1.10467680373471,1.05455393671962,22,2,"BGLAP; GC; VDR","Vitamin D receptor agonist","5353464",2
"withaferin-a","PC3","trt_cp","up",0.544118634185035,1.98444223399629e-05,6.23466946078869e-05,1.10447900922055,1.13273208063155,22,2,"ACHE; BCHE; IKBKB","IKK inhibitor","73707417",2
"nialamide","MCF7","trt_cp","up",0.55685147576491,1.92786822293938e-05,6.23466946078869e-05,1.1038883965904,0.892787234342189,22,2,"COMT; MAOA; MAOB","Monoamine oxidase inhibitor","4472",2
"clomifene","VCAP","trt_cp","up",0.540013062139689,2.0018496220138e-05,6.23466946078869e-05,1.10128882025796,0,22,2,"AR; ESR1; SHBG","Estrogen receptor antagonist","2800",2
"dacarbazine","PC3","trt_cp","up",0.542004219988595,1.99314592800504e-05,6.23466946078869e-05,1.10018706634257,1.1524392715817,22,2,"CYP2E1; PGD; POLA2",NA,"5351166",2
"BNTX","VCAP","trt_cp","up",0.539185452022189,2.00620146901818e-05,6.23466946078869e-05,1.09960101336247,1.0382319331113,22,2,"OPRD1; OPRK1; OPRM1","Opioid receptor antagonist","6438353",2
"penbutolol","MCF7","trt_cp","up",0.551561443641869,1.94962745796127e-05,6.23466946078869e-05,1.09340156961344,0.732579051641003,22,2,"ADRB1; ADRB2; HTR1B",NA,"73707345",2
"calyculin","PC3","trt_cp","up",0.538132773170198,2.01055331602256e-05,6.23466946078869e-05,1.09232861144397,0.971019006592505,22,2,"PPP1CA; PPP1CC; PPP2CA","Protein phosphatase inhibitor","5311365",2
"lomerizine","A549","trt_cp","down",-0.521465282288013,2.08453471509698e-05,6.23466946078869e-05,-1.0914473340854,-1.09245461109729,22,2,"ABCB1; CACNA1B; SCN5A","Calcium channel blocker","13579832",2
"PD-198306","NPC","trt_cp","up",0.556707405233336,1.92786822293938e-05,6.23466946078869e-05,1.09135063077694,1.09655124776476,22,2,"MAP2K1; MAP2K2; MAPK3","MAP kinase inhibitor; MEK inhibitor","9956637",2
"temsirolimus","HCC515","trt_cp","up",0.542928884672956,1.98879408100067e-05,6.23466946078869e-05,1.09094519563881,0,22,2,"IFNAR1; MTOR; PTEN","MTOR inhibitor","6440033",2
"PD-166793","VCAP","trt_cp","down",-0.522524672114305,2.07583102108822e-05,6.23466946078869e-05,-1.08820731862816,-0.670792545795889,22,2,"MMP13; MMP2; MMP3","Collagenase inhibitor; Metalloproteinase inhibitor","9918908",2
"PD-166793","HCC515","trt_cp","down",-0.528305974743523,2.05407178606633e-05,6.23466946078869e-05,-1.07669033670994,-0.670792545795889,22,2,"MMP13; MMP2; MMP3","Collagenase inhibitor; Metalloproteinase inhibitor","9918908",2
"PD-198306","SKB","trt_cp","up",0.540982704437658,1.99749777500942e-05,6.23466946078869e-05,1.07572209167145,1.09655124776476,22,2,"MAP2K1; MAP2K2; MAPK3","MAP kinase inhibitor; MEK inhibitor","9956637",2
"TW-37","A549","trt_cp","up",0.550630294975593,1.95397930496564e-05,6.23466946078869e-05,1.07482890776035,1.15017757570275,22,2,"BCL2; BCL2L1; MCL1","BCL inhibitor","11455910",2
"lysergol","A549","trt_cp","up",0.54933908969728,1.9626829989744e-05,6.23466946078869e-05,1.07230847840576,0,22,2,"HTR1B; HTR1D; HTR1E","Ergoline alkaloid","14987",2
"triflusal","MCF7","trt_cp","down",-0.522215315653445,2.0801828680926e-05,6.23466946078869e-05,-1.07026215592231,-0.717075644467949,22,2,"NFKB1; NOS2; PDE10A",NA,"9458",2
"fluocinonide","PC3","trt_cp","up",0.525127144894711,2.06712732707947e-05,6.23466946078869e-05,1.06592914167849,0.969868179354128,22,2,"NR3C1; SERPINA6; SMO","Glucocorticoid receptor agonist","7067797",2
"SB-216641","A549","trt_cp","down",-0.5077202261344,2.14110872615389e-05,6.23466946078869e-05,-1.06267839125206,-0.0212395714905236,22,2,"HTR1B; HTR1D; HTR2B","Serotonin receptor antagonist","3292447",2
"linsitinib","HS578T","trt_cp","up",0.583168810838926,1.81472020082555e-05,6.23466946078869e-05,1.06103982168497,0.708572728445391,22,2,"IGF1R; INSR; INSRR","IGF-1 inhibitor","11640390",2
"pitavastatin","MCF7","trt_cp","up",0.534148101382013,2.02796070404007e-05,6.23466946078869e-05,1.05888179674203,1.0615295506022,22,2,"APOA1; CYP2C8; HMGCR","HMGCR inhibitor","11251522",2
"linsitinib","A375","trt_cp","up",0.538355150042307,2.01055331602256e-05,6.23466946078869e-05,1.05362022264998,0.708572728445391,22,2,"IGF1R; INSR; INSRR","IGF-1 inhibitor","11640390",2
"7-nitroindazole","A549","trt_cp","up",0.539732664384162,2.0018496220138e-05,6.23466946078869e-05,1.05355676110833,0.0105355676110836,22,2,"NOS1; NOS2; NOS3","nitric oxide synthase inhibitor","1893",2
"calcipotriol","MCF7","trt_cp","up",0.531448926953921,2.0410162450532e-05,6.23466946078869e-05,1.05353102106625,1.05455393671962,22,2,"BGLAP; GC; VDR","Vitamin D receptor agonist","5353464",2
"lomerizine","PC3","trt_cp","down",-0.507425282214342,2.14546057315827e-05,6.23466946078869e-05,-1.04908681988959,-1.09245461109729,22,2,"ABCB1; CACNA1B; SCN5A","Calcium channel blocker","13579832",2
"midodrine","A549","trt_cp","down",-0.5010984005743,2.17157165518454e-05,6.23466946078869e-05,-1.04881865005771,-1.01998389408035,22,2,"ADRA1A; ADRA1B; ADRA1D","Adrenergic receptor agonist","4195",2
"equol","A549","trt_cp","up",0.534698812643852,2.02360885703569e-05,6.23466946078869e-05,1.04373069556629,1.12970129866843,22,2,"ESR1; ESR2; SHBG","Estrogen receptor agonist","382975",2
"PD-166793","NPC","trt_cp","down",-0.508761387888985,2.13675687914951e-05,6.23466946078869e-05,-1.04313033730317,-0.670792545795889,22,2,"MMP13; MMP2; MMP3","Collagenase inhibitor; Metalloproteinase inhibitor","9918908",2
"oxindole-I","SKB","trt_cp","up",0.52455577917992,2.06712732707947e-05,6.23466946078869e-05,1.04305781931481,0.92107579638716,22,2,"AKT1; KDR; RET","VEGFR inhibitor","5908088",2
"ampicillin","PC3","trt_cp","down",-0.498946732170948,2.18027534919329e-05,6.23466946078869e-05,-1.03155766749205,-0.350729606947296,22,2,"SLC15A1; SLC15A2; TEK","Bacterial cell wall synthesis inhibitor","2174",2
"etoricoxib","PC3","trt_cp","down",-0.495479803508734,2.1976827372108e-05,6.23466946078869e-05,-1.02438989463463,-0.922150933394518,22,2,"LTF; PTGER2; TF",NA,"123619",2
"tienilic-acid","VCAP","trt_cp","down",-0.489883930596357,2.21944197223269e-05,6.23466946078869e-05,-1.02022987047905,-0.346878155962878,22,2,"CYP2C9; SLC12A1; SLC22A12","Sodium/potassium/chloride transporter inhibitor","38409",2
"midodrine","NPC","trt_cp","down",-0.497037322539307,2.18897904320205e-05,6.23466946078869e-05,-1.01909209750373,-1.01998389408035,22,2,"ADRA1A; ADRA1B; ADRA1D","Adrenergic receptor agonist","4195",2
"pevonedistat","A375","trt_cp","up",0.520374890597744,2.08888656210136e-05,6.23466946078869e-05,1.01843087792504,0.964246857889862,22,2,"NAE1; NEDD8; UBA3",NA,"16720766",2
"venlafaxine","NPC","trt_cp","down",-0.495783065203239,2.19333089020643e-05,6.23466946078869e-05,-1.01652045211321,0,22,2,"SLC6A2; SLC6A3; SLC6A4","Adrenergic inhibitor; Norepinephrine reuptake inhibitor; Serotonin reuptake inhibitor","5656",2
"calcipotriol","PC3","trt_cp","up",0.500542154757354,2.17157165518454e-05,6.23466946078869e-05,1.01602530850197,1.05455393671962,22,2,"BGLAP; GC; VDR","Vitamin D receptor agonist","5353464",2
"phenanthridone","ASC","trt_cp","down",-0.50334830595442,2.16286796117578e-05,6.23466946078869e-05,-1.01035044579415,-0.0290768399005847,22,2,"PARP1; PARP14; TNKS2","PARP inhibitor","1853",2
"oxindole-I","HA1E","trt_cp","up",0.542537950920891,1.98879408100067e-05,6.23466946078869e-05,1.00693918281103,0.92107579638716,22,2,"AKT1; KDR; RET","VEGFR inhibitor","5908088",2
"withaferin-a","ASC","trt_cp","up",0.476152865147276,2.28036783029398e-05,6.23466946078869e-05,1.00539452599247,1.13273208063155,22,2,"ACHE; BCHE; IKBKB","IKK inhibitor","73707417",2
"BNTX","HA1E","trt_cp","up",0.541593899924878,1.99314592800504e-05,6.23466946078869e-05,1.00518704374529,1.0382319331113,22,2,"OPRD1; OPRK1; OPRM1","Opioid receptor antagonist","6438353",2
"solifenacin","A375","trt_cp","down",-0.48630460098235,2.2368493602502e-05,6.23466946078869e-05,-1.00418957200895,-0.839747542055972,22,2,"CHRM1; CHRM4; CHRM5","Acetylcholine receptor antagonist","154059",2
"mebeverine","HA1E","trt_cp","down",-0.474537313100658,2.28471967729836e-05,6.23466946078869e-05,-1.00097229088302,-0.867827799384055,22,2,"CHRM1; CHRM4; IL13","Acetylcholine receptor antagonist","4031",2
"MDL-28170","NPC","trt_cp","down",-0.487733147905096,2.22814566624145e-05,6.23466946078869e-05,-1.00001543984937,-0.030000463195481,22,2,"CAPN1; CTSB; CTSL","Calpain inhibitor","72430",2
"trimethoprim","PC3","trt_cp","up",0.490556958645225,2.21509012522831e-05,6.23466946078869e-05,0.995756861850965,0.667157097440146,22,2,"DHFR; PDF; TYMS",NA,"5578",2
"hyperoside","PC3","trt_cp","up",0.48791975717273,2.22814566624145e-05,6.23466946078869e-05,0.990403739413211,0.00990403739413234,22,2,"ACE; AKR1B1; GAA","Glucosidase inhibitor","5281643",2
"prednisone","HCC515","trt_cp","down",-0.485439543820165,2.24120120725458e-05,6.23466946078869e-05,-0.989328326528565,-0.85402848116663,22,2,"HSD11B1; NR3C1; SERPINA6","Glucocorticoid receptor agonist","5865",2
"rivaroxaban","ASC","trt_cp","down",-0.488900312153091,2.22379381923707e-05,6.23466946078869e-05,-0.981349579385505,-0.288583397449827,22,2,"CYP2J2; CYP3A5; F10","Coagulation inhibitor","9875401",2
"MDL-29951","SKB","trt_cp","down",-0.452191161799319,2.38481215839905e-05,6.23466946078869e-05,-0.973489272026983,-0.718335837997622,22,2,"FBP1; FBP2; GPR17","Glutamate receptor antagonist","446916",2
"linsitinib","BT20","trt_cp","up",0.481817801376262,2.25425674826771e-05,6.23466946078869e-05,0.970020462007464,0.708572728445391,22,2,"IGF1R; INSR; INSRR","IGF-1 inhibitor","11640390",2
"phenanthridone","NPC","trt_cp","down",-0.472717323177226,2.29342337130712e-05,6.23466946078869e-05,-0.969227996686164,-0.0290768399005847,22,2,"PARP1; PARP14; TNKS2","PARP inhibitor","1853",2
"calyculin","MCF7","trt_cp","up",0.488577258189945,2.22379381923707e-05,6.23466946078869e-05,0.968543300371047,0.971019006592505,22,2,"PPP1CA; PPP1CC; PPP2CA","Protein phosphatase inhibitor","5311365",2
"midodrine","PC3","trt_cp","down",-0.467370326081175,2.31953445333338e-05,6.23466946078869e-05,-0.966274378287966,-1.01998389408035,22,2,"ADRA1A; ADRA1B; ADRA1D","Adrenergic receptor agonist","4195",2
"mycophenolate-mofetil","ASC","trt_cp","down",-0.480990362633292,2.25860859527209e-05,6.23466946078869e-05,-0.965472261573966,0,22,2,"HCAR2; IMPDH1; IMPDH2","Dehydrogenase inhibitor; Hydroxycarboxylic acid receptor agonist; Immunosuppressant; Inosine monophosphate dehydrogenase inhibitor; Inositol monophosphatase inhibitor","5281078",2
"pitavastatin","PC3","trt_cp","up",0.47415738543316,2.28907152430274e-05,6.23466946078869e-05,0.962468194205847,1.0615295506022,22,2,"APOA1; CYP2C8; HMGCR","HMGCR inhibitor","11251522",2
"mebeverine","MCF7","trt_cp","down",-0.467764996153402,2.315182606329e-05,6.23466946078869e-05,-0.958668116850795,-0.867827799384055,22,2,"CHRM1; CHRM4; IL13","Acetylcholine receptor antagonist","4031",2
"argatroban","A549","trt_cp","up",0.488259188237432,2.22814566624145e-05,6.23466946078869e-05,0.953080669163792,0.954985277718957,22,2,"CYP3A5; F2; SELP","Thrombin inhibitor","92722",2
"calyculin","VCAP","trt_cp","up",0.464184127297112,2.33258999434652e-05,6.23466946078869e-05,0.946645230965305,0.971019006592505,22,2,"PPP1CA; PPP1CC; PPP2CA","Protein phosphatase inhibitor","5311365",2
"mebeverine","NEU","trt_cp","down",-0.473433367885968,2.29342337130712e-05,6.23466946078869e-05,-0.944839609117932,-0.867827799384055,22,2,"CHRM1; CHRM4; IL13","Acetylcholine receptor antagonist","4031",2
"pevonedistat","HCC515","trt_cp","up",0.464706943116872,2.32823814734214e-05,6.23466946078869e-05,0.933768346620077,0.964246857889862,22,2,"NAE1; NEDD8; UBA3",NA,"16720766",2
"withaferin-a","PHH","trt_cp","up",0.447229639822783,2.40657139342094e-05,6.23466946078869e-05,0.932751070921624,1.13273208063155,22,2,"ACHE; BCHE; IKBKB","IKK inhibitor","73707417",2
"YK-4279","HA1E","trt_cp","down",-0.43839425137652,2.44573801646034e-05,6.23466946078869e-05,-0.924733389758167,0,22,2,"DHX9; EWSR1; FLI1","Apoptosis stimulant; EWS-FLI1 inhibitor","44632017",2
"fluocinonide","MCF7","trt_cp","up",0.464282625042636,2.33258999434652e-05,6.23466946078869e-05,0.920382229065821,0.969868179354128,22,2,"NR3C1; SERPINA6; SMO","Glucocorticoid receptor agonist","7067797",2
"oxindole-I","HCC515","trt_cp","up",0.457068670267345,2.36305292337716e-05,6.23466946078869e-05,0.918420227734876,0.92107579638716,22,2,"AKT1; KDR; RET","VEGFR inhibitor","5908088",2
"IRL-2500","PHH","trt_cp","down",-0.445551023980326,2.41092324042532e-05,6.23466946078869e-05,-0.915604029473281,-0.868184738683125,22,2,"EDNRB; HBA2; HBB","Endothelin receptor antagonist","4574540",2
"dicoumarol","PC3","trt_cp","down",-0.440834442014023,2.43268247544721e-05,6.23466946078869e-05,-0.911412219848631,-0.610646187298583,22,2,"CRYZ; NQO1; VKORC1",NA,"653",2
"IRL-2500","NPC","trt_cp","down",-0.444435210427898,2.41962693443407e-05,6.23466946078869e-05,-0.911240243460105,-0.868184738683125,22,2,"EDNRB; HBA2; HBB","Endothelin receptor antagonist","4574540",2
"BNTX","PC3","trt_cp","up",0.44505380347147,2.41527508742969e-05,6.23466946078869e-05,0.903392299078747,1.0382319331113,22,2,"OPRD1; OPRK1; OPRM1","Opioid receptor antagonist","6438353",2
"MDL-29951","A549","trt_cp","down",-0.431609929192775,2.47184909848661e-05,6.23466946078869e-05,-0.903376547936814,-0.718335837997622,22,2,"FBP1; FBP2; GPR17","Glutamate receptor antagonist","446916",2
"PD-198306","HA1E","trt_cp","up",0.482274040100668,2.25425674826771e-05,6.23466946078869e-05,0.895090614408927,1.09655124776476,22,2,"MAP2K1; MAP2K2; MAPK3","MAP kinase inhibitor; MEK inhibitor","9956637",2
"nialamide","VCAP","trt_cp","up",0.43672946703104,2.45008986346472e-05,6.23466946078869e-05,0.890654899369985,0.892787234342189,22,2,"COMT; MAOA; MAOB","Monoamine oxidase inhibitor","4472",2
"BNTX","A549","trt_cp","up",0.45223045161148,2.38481215839905e-05,6.23466946078869e-05,0.882752668708652,1.0382319331113,22,2,"OPRD1; OPRK1; OPRM1","Opioid receptor antagonist","6438353",2
"pevonedistat","VCAP","trt_cp","up",0.429918791176452,2.48055279249536e-05,6.23466946078869e-05,0.876765381313996,0.964246857889862,22,2,"NAE1; NEDD8; UBA3",NA,"16720766",2
"IRL-2500","SKB","trt_cp","down",-0.402658080604449,2.59805266161356e-05,6.23466946078869e-05,-0.866853125133321,-0.868184738683125,22,2,"EDNRB; HBA2; HBB","Endothelin receptor antagonist","4574540",2
"mebeverine","NPC","trt_cp","down",-0.42210018028888,2.51536756853038e-05,6.23466946078869e-05,-0.865445990835585,-0.867827799384055,22,2,"CHRM1; CHRM4; IL13","Acetylcholine receptor antagonist","4031",2
"boldine","HCC515","trt_cp","down",-0.42460610604375,2.50231202751725e-05,6.23466946078869e-05,-0.865349462510401,0,22,2,"CHRNA4; CHRNB2; DRD1","Acetylcholine receptor antagonist; Dopamine receptor antagonist","10154",2
"AKT-inhibitor-1-2","HCC515","trt_cp","up",0.425863509849167,2.49796018051287e-05,6.23466946078869e-05,0.855717504047857,0,22,2,"AKT1; AKT2; AKT3","AKT inhibitor","10196499",2
"prednisone","VCAP","trt_cp","down",-0.408069697428858,2.57629342659167e-05,6.23466946078869e-05,-0.849843949866777,-0.85402848116663,22,2,"HSD11B1; NR3C1; SERPINA6","Glucocorticoid receptor agonist","5865",2
"oxindole-I","VCAP","trt_cp","up",0.415271065298918,2.54583049756103e-05,6.23466946078869e-05,0.846893183987484,0.92107579638716,22,2,"AKT1; KDR; RET","VEGFR inhibitor","5908088",2
"candesartan","MCF7","trt_cp","down",-0.413221806562897,2.55453419156978e-05,6.23466946078869e-05,-0.846883743753717,-0.56741210831499,22,2,"AGTR1; AGTR2; SERPINE1","Angiotensin receptor antagonist","2541",2
"chlorthalidone","A549","trt_cp","down",-0.404084657700052,2.59370081460919e-05,6.23466946078869e-05,-0.845765072712819,-0.0240453712737819,22,2,"CA5B; CA7; SLC12A1",NA,"2732",2
"solifenacin","PC3","trt_cp","down",-0.404548247699044,2.58934896760481e-05,6.23466946078869e-05,-0.836391582261013,-0.839747542055972,22,2,"CHRM1; CHRM4; CHRM5","Acetylcholine receptor antagonist","154059",2
"L-741626","SKB","trt_cp","down",-0.376064384102203,2.71555253073176e-05,6.23466946078869e-05,-0.809601501405285,-0.682744899578111,22,2,"DRD3; DRD4; HTR2B","Dopamine receptor antagonist","133633",2
"phenylbutazone","PHH","trt_cp","down",-0.393406486593339,2.64157113165734e-05,6.23466946078869e-05,-0.808447394257798,-1.1517756858809,22,2,"CYP2C9; PTGIS; PTGR2","Cyclooxygenase inhibitor; Prostanoid receptor antagonist","4781",2
"pevonedistat","HA1E","trt_cp","up",0.43388025787152,2.46314540447785e-05,6.23466946078869e-05,0.805272758444674,0.964246857889862,22,2,"NAE1; NEDD8; UBA3",NA,"16720766",2
"latrunculin-b","PC3","trt_cp","up",0.396504478460725,2.62416374363983e-05,6.23466946078869e-05,0.804844469584711,0,22,2,"ACTA1; MKL1; SPIRE2","Actin polymerization inhibitor; Unidentified pharmacological activity","6436219",2
"rivaroxaban","MCF7","trt_cp","down",-0.391136438337118,2.6502748256661e-05,6.23466946078869e-05,-0.801620548471742,-0.288583397449827,22,2,"CYP2J2; CYP3A5; F10","Coagulation inhibitor","9875401",2
"chlorthalidone","SKB","trt_cp","down",-0.372306940426359,2.73295991874928e-05,6.23466946078869e-05,-0.801512375792735,-0.0240453712737819,22,2,"CA5B; CA7; SLC12A1",NA,"2732",2
"acetohexamide","MCF7","trt_cp","down",-0.387683025800263,2.66333036667923e-05,6.23466946078869e-05,-0.794542899394447,-0.532343742594279,22,2,"DCXR; KCNJ1; KCNJ10",NA,"1989",2
"withaferin-a","NEU","trt_cp","up",0.410618681275201,2.56323788557854e-05,6.23466946078869e-05,0.762985091085233,1.13273208063155,22,2,"ACHE; BCHE; IKBKB","IKK inhibitor","73707417",2
"profenamine","PC3","trt_cp","up",0.375705473941647,2.71555253073176e-05,6.23466946078869e-05,0.76262561792121,0.0152525123584246,22,2,"BCHE; CHRM1; GRIN3A","Butyrylcholinesterase inhibitor; Cholinergic receptor antagonist","3290",2
"glycopyrrolate","A549","trt_cp","up",0.387274166317989,2.66768221368361e-05,6.23466946078869e-05,0.75595816827662,0.00755958168276637,22,2,"CHRM1; CHRM4; CHRM5","Acetylcholine receptor antagonist","11693",2
"L-741626","PC3","trt_cp","down",-0.364881566027833,2.76342284777992e-05,6.23466946078869e-05,-0.75438188666913,-0.682744899578111,22,2,"DRD3; DRD4; HTR2B","Dopamine receptor antagonist","133633",2
"isoeugenol","VCAP","trt_cp","up",0.356941751718335,2.80258947081932e-05,6.23466946078869e-05,0.727937874489803,0.731892848033884,22,2,"EPX; LPO; MPO","Nitric oxide production inhibitor","5318562",2
"IRL-2500","VCAP","trt_cp","down",-0.348633460982676,2.9440244984616e-05,6.45001858558835e-05,-0.726062335439392,-0.868184738683125,22,2,"EDNRB; HBA2; HBB","Endothelin receptor antagonist","4574540",2
"etoricoxib","MCF7","trt_cp","down",-0.348664048623611,2.9440244984616e-05,6.45001858558835e-05,-0.714574860573693,-0.922150933394518,22,2,"LTF; PTGER2; TF",NA,"123619",2
"MDL-29951","HA1E","trt_cp","down",-0.337832952918468,3.52499607354604e-05,7.56843204802289e-05,-0.712612929442802,-0.718335837997622,22,2,"FBP1; FBP2; GPR17","Glutamate receptor antagonist","446916",2
"SB-216641","PC3","trt_cp","down",-0.342440535055844,3.18990385420895e-05,6.89794944118325e-05,-0.707985716350791,-0.0212395714905236,22,2,"HTR1B; HTR1D; HTR2B","Serotonin receptor antagonist","3292447",2
"prednisone","PHH","trt_cp","down",-0.34076830725204,3.25082971227024e-05,7.01715031738333e-05,-0.700276328509873,-0.85402848116663,22,2,"HSD11B1; NR3C1; SERPINA6","Glucocorticoid receptor agonist","5865",2
"linsitinib","HT29","trt_cp","up",0.338803767416899,3.43795913345848e-05,7.3915719268874e-05,0.697679072880304,0.708572728445391,22,2,"IGF1R; INSR; INSRR","IGF-1 inhibitor","11640390",2
"L-741626","HA1E","trt_cp","down",-0.322622872982173,7.19577902173874e-05,0.000151706221085891,-0.68052932265777,-0.682744899578111,22,2,"DRD3; DRD4; HTR2B","Dopamine receptor antagonist","133633",2
"PD-166793","ASC","trt_cp","down",-0.328446366601745,5.31360519234533e-05,0.000112608734249215,-0.659276943996694,-0.670792545795889,22,2,"MMP13; MMP2; MMP3","Collagenase inhibitor; Metalloproteinase inhibitor","9918908",2
"pevonedistat","MCF7","trt_cp","up",0.32682621489909,5.60082709463426e-05,0.000118575395015899,0.64789208977688,0.964246857889862,22,2,"NAE1; NEDD8; UBA3",NA,"16720766",2
"guanethidine","PC3","trt_cp","up",0.267035226121257,0.00798516054986283,0.0163241120208851,0.542041355402459,0.363167708119647,22,2,"DBH; SLC6A2; TH",NA,"73707360",2
"QL-XII-47","MCF7","trt_cp","up",0.786396143891591,9.31295258936855e-06,6.23466946078869e-05,1.55893198841383,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"rottlerin","NEU","trt_cp","up",0.807166159088647,8.39906471844921e-06,6.23466946078869e-05,1.49982398146278,1.19167011110592,22,2,"KCNH2; TGM2","MAP kinase inhibitor; Protein kinase inhibitor","5281847",1
"penfluridol","ASC","trt_cp","up",0.681571960731183,1.38388734739215e-05,6.23466946078869e-05,1.43913597616835,1.11091970943673,22,2,"CACNA1G; DRD1","T-type calcium channel blocker","33630",1
"levocabastine","NEU","trt_cp","down",-0.717696242273824,1.22722085523455e-05,6.23466946078869e-05,-1.43231948361261,-0.902980712739643,22,2,"HRH1; NTSR2","Histamine receptor antagonist","54385",1
"rottlerin","ASC","trt_cp","up",0.675786912883565,1.40999842941842e-05,6.23466946078869e-05,1.42692087495963,1.19167011110592,22,2,"KCNH2; TGM2","MAP kinase inhibitor; Protein kinase inhibitor","5281847",1
"leu-enkephalin","HA1E","trt_cp","up",0.750674086217299,1.08360990409008e-05,6.23466946078869e-05,1.39323553246376,0.861347418977871,22,2,"OPRD1; OPRM1","Opioid receptor agonist","461776",1
"QL-XII-47","PC3","trt_cp","up",0.685961821713775,1.36647995937464e-05,6.23466946078869e-05,1.39239935118985,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"torin-1","ASC","trt_cp","up",0.653529438516931,1.50573906351473e-05,6.23466946078869e-05,1.37992432295167,1.01527879030255,22,2,"MTOR; PIK3CA","MTOR inhibitor; PI3K inhibitor","49836027",1
"rottlerin","A549","trt_cp","up",0.706554918145525,1.2750911722827e-05,6.23466946078869e-05,1.37919336780538,1.19167011110592,22,2,"KCNH2; TGM2","MAP kinase inhibitor; Protein kinase inhibitor","5281847",1
"QL-XII-47","MDAMB231","trt_cp","up",0.68045942624165,1.3925910414009e-05,6.23466946078869e-05,1.37332171256486,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"CDK2-5-inhibitor","HCC515","trt_cp","down",-0.664892194044977,1.45786874646657e-05,6.23466946078869e-05,-1.35505376525343,-1.09757493335153,22,2,"CDK2; CDK5","CDK inhibitor","NotFound",1
"salubrinal","MCF7","trt_cp","up",0.680148807466831,1.3925910414009e-05,6.23466946078869e-05,1.34830993396596,1.19362065469059,22,2,"EIF2S1; SLC6A9","Eukaryotic translation initiation factor inhibitor","5717801",1
"torin-1","MCF10A","trt_cp","up",0.656051949959671,1.49703536950597e-05,6.23466946078869e-05,1.33816414786989,1.01527879030255,22,2,"MTOR; PIK3CA","MTOR inhibitor; PI3K inhibitor","49836027",1
"CGK-733","NPC","trt_cp","up",0.673227063187721,1.42305397043155e-05,6.23466946078869e-05,1.31977188224769,1.14602795905068,22,2,"ATM; ATR","ATR kinase inhibitor","6605258",1
"CDK2-5-inhibitor","VCAP","trt_cp","down",-0.633423230684731,1.59712785060666e-05,6.23466946078869e-05,-1.31916411263626,-1.09757493335153,22,2,"CDK2; CDK5","CDK inhibitor","NotFound",1
"BMS-345541","VCAP","trt_cp","up",0.643267454322502,1.55360938056288e-05,6.23466946078869e-05,1.31186318544627,1.01501955040761,22,2,"CHUK; IKBKB","IKK inhibitor","9813758",1
"WYE-125132","SKB","trt_cp","up",0.659029390996769,1.48397982849284e-05,6.23466946078869e-05,1.31045312380722,1.03401072813833,22,2,"MTOR; PIK3CA","MTOR inhibitor","25260757",1
"allantoin","A375","trt_cp","down",-0.633561222275762,1.59277600360228e-05,6.23466946078869e-05,-1.30826558365557,-1.00028507097357,22,2,"TTR; URAD",NA,"204",1
"metolazone","MCF7","trt_cp","down",-0.636619170421044,1.57972046258915e-05,6.23466946078869e-05,-1.30472888368609,-0.973767477278073,22,2,"CA7; SLC12A3","Carbonic anhydrase inhibitor","4170",1
"terbinafine","PC3","trt_cp","up",0.642313023693627,1.55796122756726e-05,6.23466946078869e-05,1.30379885460299,0.0130379885460302,22,2,"CYP2C8; SQLE","Fungal squalene epoxidase inhibitor","5282481",1
"CGK-733","HEPG2","trt_cp","up",0.697713570444492,1.3142577953221e-05,6.23466946078869e-05,1.3008604183345,1.14602795905068,22,2,"ATM; ATR","ATR kinase inhibitor","6605258",1
"CMPD-1","MCF7","trt_cp","down",-0.628129309943829,1.61888708562855e-05,6.23466946078869e-05,-1.28732920944166,-0.0178318184956333,22,2,"GNRHR; MAPK14","p38 MAPK inhibitor","11382492",1
"tegaserod","PC3","trt_cp","up",0.633682799587001,1.59277600360228e-05,6.23466946078869e-05,1.28628079737836,1.19994864810264,22,2,"HTR2B; HTR4","Serotonin receptor partial agonist","6918369",1
"metanephrine","VCAP","trt_cp","down",-0.616033508600084,1.67110924968109e-05,6.23466946078869e-05,-1.28294836273712,-0.920038722541622,22,2,"COMT; LRTOMT","Epinephrine metabolite","21100",1
"CGK-733","MCF7","trt_cp","up",0.647002001119993,1.53620199254537e-05,6.23466946078869e-05,1.28260053657227,1.14602795905068,22,2,"ATM; ATR","ATR kinase inhibitor","6605258",1
"carisoprodol","MCF7","trt_cp","up",0.643997784090116,1.54925753355851e-05,6.23466946078869e-05,1.27664505209489,0.855352184903578,22,2,"GABRB2; GABRG2",NA,"2576",1
"WYE-125132","HS578T","trt_cp","up",0.700052866415307,1.30555410131335e-05,6.23466946078869e-05,1.27370317950098,1.03401072813833,22,2,"MTOR; PIK3CA","MTOR inhibitor","25260757",1
"QX-314","PC3","trt_cp","down",-0.613600286602837,1.67981294368984e-05,6.23466946078869e-05,-1.26860051305759,-0.813769577354987,22,2,"MAPK14; TGFBR1","Sodium channel blocker","9884487",1
"tyrphostin-AG-555","VCAP","trt_cp","up",0.62099453336648,1.6493500146592e-05,6.23466946078869e-05,1.2664403604017,1.12013668179999,22,2,"CDK2; EGFR","EGFR inhibitor","5328770",1
"BMS-345541","NPC","trt_cp","up",0.645109621635882,1.54490568655413e-05,6.23466946078869e-05,1.26465138755879,1.01501955040761,22,2,"CHUK; IKBKB","IKK inhibitor","9813758",1
"tyrphostin-AG-555","PC3","trt_cp","up",0.623011089735489,1.64064632065044e-05,6.23466946078869e-05,1.26461883106629,1.12013668179999,22,2,"CDK2; EGFR","EGFR inhibitor","5328770",1
"zebularine","HA1E","trt_cp","down",-0.595631347898063,1.75814618976864e-05,6.23466946078869e-05,-1.25640378188933,0,22,2,"CDA; DNMT1","DNA methyltransferase inhibitor","46783268",1
"QL-XII-47","MCF10A","trt_cp","up",0.61586910111208,1.67110924968109e-05,6.23466946078869e-05,1.25620227321892,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"digitoxigenin","A375","trt_cp","up",0.641845511253474,1.55796122756726e-05,6.23466946078869e-05,1.25616223866462,1.21682181514129,22,2,"ATP12A; ATP1A1","ATPase inhibitor","4369270",1
"penfluridol","NPC","trt_cp","up",0.639773105725308,1.56666492157602e-05,6.23466946078869e-05,1.25418985974291,1.11091970943673,22,2,"CACNA1G; DRD1","T-type calcium channel blocker","33630",1
"griseofulvin","PC3","trt_cp","down",-0.606589018756281,1.71027587272049e-05,6.23466946078869e-05,-1.25410492336912,-1.21597631928125,22,2,"KRT12; KRT16","Tubulin inhibitor","441140",1
"CGK-733","VCAP","trt_cp","up",0.612050341876874,1.6885166376986e-05,6.23466946078869e-05,1.24819980515528,1.14602795905068,22,2,"ATM; ATR","ATR kinase inhibitor","6605258",1
"rottlerin","PHH","trt_cp","up",0.5959376432868,1.75814618976864e-05,6.23466946078869e-05,1.2428994536197,1.19167011110592,22,2,"KCNH2; TGM2","MAP kinase inhibitor; Protein kinase inhibitor","5281847",1
"selumetinib","MCF7","trt_cp","up",0.625054619710509,1.63194262664169e-05,6.23466946078869e-05,1.23909259822983,0.753301492900516,22,2,"MAP2K1; MAP2K2","MEK inhibitor","10127622",1
"cetirizine","VCAP","trt_cp","down",-0.594187936810844,1.7668498837774e-05,6.23466946078869e-05,-1.23745288210369,-0.863838333298333,22,2,"HRH1; IL8","Histamine receptor antagonist","2678",1
"pyridine-2-aldoxime","VCAP","trt_cp","up",0.605328745390347,1.71897956672924e-05,6.23466946078869e-05,1.23449195328301,0.954935014659163,22,2,"ACHE; BCHE","Acetylcholinesterase inhibitor","5353895",1
"digitoxigenin","PC3","trt_cp","up",0.607535676316215,1.70592402571611e-05,6.23466946078869e-05,1.23320606883624,1.21682181514129,22,2,"ATP12A; ATP1A1","ATPase inhibitor","4369270",1
"ganciclovir","VCAP","trt_cp","up",0.603497756800668,1.727683260738e-05,6.23466946078869e-05,1.23075788200732,0.41845767988249,22,2,"B3GALT4; B4GALNT1","DNA polymerase inhibitor","3454",1
"PF-562271","SKB","trt_cp","up",0.618776861779778,1.65805370866795e-05,6.23466946078869e-05,1.2304126075963,0.742058598132709,22,2,"PTK2; PTK2B","Focal adhesion kinase inhibitor","11713159",1
"dequalinium","MCF7","trt_cp","up",0.620296890222654,1.65370186166357e-05,6.23466946078869e-05,1.22966099464372,0.823872866411289,22,2,"CNGA1; KCNMA1",NA,"2993",1
"FTI-276","VCAP","trt_cp","up",0.601462495300414,1.73638695474675e-05,6.23466946078869e-05,1.22660722178505,0,22,2,"FNTA; FNTB","Farnesyltransferase inhibitor","395754",1
"EO-1428","PC3","trt_cp","up",0.603957315386706,1.72333141373362e-05,6.23466946078869e-05,1.22594253422126,0.552288513873091,22,2,"MAPK11; MAPK14","p38 MAPK inhibitor","9801969",1
"QL-XII-47","A549","trt_cp","up",0.627878392394701,1.61888708562855e-05,6.23466946078869e-05,1.22561699358339,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"isoquercetin","PC3","trt_cp","up",0.600159434789556,1.74073880175113e-05,6.23466946078869e-05,1.21823340768976,0.910724333182646,22,2,"ACE; AKR1B1","Aldose reductase inhibitor","5280804",1
"chaetocin","A549","trt_cp","up",0.624090379450942,1.63629447364606e-05,6.23466946078869e-05,1.21822280214119,1.21822280214119,22,2,"EHMT2; SUV39H1","Histone lysine methyltransferase inhibitor","161591",1
"torin-1","MCF7","trt_cp","up",0.611013802159931,1.69286848470297e-05,6.23466946078869e-05,1.21125843374022,1.01527879030255,22,2,"MTOR; PIK3CA","MTOR inhibitor; PI3K inhibitor","49836027",1
"citalopram","PC3","trt_cp","up",0.595168726596265,1.76249803677302e-05,6.23466946078869e-05,1.20810302050151,0,22,2,"SLC6A2; SLC6A4","Serotonin reuptake inhibitor","2771",1
"digitoxigenin","HA1E","trt_cp","up",0.650869087256294,1.51879460452786e-05,6.23466946078869e-05,1.20799952469017,1.21682181514129,22,2,"ATP12A; ATP1A1","ATPase inhibitor","4369270",1
"dolasetron","VCAP","trt_cp","up",0.591875065544288,1.77555357778615e-05,6.23466946078869e-05,1.20705486287804,1.04515630195565,22,2,"DCXR; HTR3A","Serotonin receptor antagonist","3033817",1
"pelitinib","BT20","trt_cp","up",0.59852241298112,1.74509064875551e-05,6.23466946078869e-05,1.20497620864859,0.94894582815744,22,2,"EGF; EGFR",NA,"6445562",1
"rimonabant","NPC","trt_cp","up",0.613688117561794,1.67981294368984e-05,6.23466946078869e-05,1.20305371889325,1.10595169285589,22,2,"CNR1; GPR55",NA,"104850",1
"DL-PDMP","A549","trt_cp","up",0.615137931852711,1.67546109668546e-05,6.23466946078869e-05,1.20074764764717,0.804500923923602,22,2,"ASAH1; UGCG","Glucosyltransferase inhibitor","16219895",1
"rottlerin","A375","trt_cp","up",0.613003130646568,1.68416479069422e-05,6.23466946078869e-05,1.19971452849706,1.19167011110592,22,2,"KCNH2; TGM2","MAP kinase inhibitor; Protein kinase inhibitor","5281847",1
"tegaserod","VCAP","trt_cp","up",0.587962955709902,1.79296096580367e-05,6.23466946078869e-05,1.19907660619077,1.19994864810264,22,2,"HTR2B; HTR4","Serotonin receptor partial agonist","6918369",1
"salubrinal","A549","trt_cp","up",0.613546641857498,1.67981294368984e-05,6.23466946078869e-05,1.19764145370344,1.19362065469059,22,2,"EIF2S1; SLC6A9","Eukaryotic translation initiation factor inhibitor","5717801",1
"valdecoxib","MCF7","trt_cp","up",0.603682461524398,1.72333141373362e-05,6.23466946078869e-05,1.19672496797558,0.0119672496797561,22,2,"CA12; CA3","Cyclooxygenase inhibitor","119607",1
"griseofulvin","VCAP","trt_cp","down",-0.574444026384954,1.85388682386495e-05,6.23466946078869e-05,-1.19633431111477,-1.21597631928125,22,2,"KRT12; KRT16","Tubulin inhibitor","441140",1
"salubrinal","HA1E","trt_cp","up",0.643077552371892,1.55360938056288e-05,6.23466946078869e-05,1.19353859756788,1.19362065469059,22,2,"EIF2S1; SLC6A9","Eukaryotic translation initiation factor inhibitor","5717801",1
"CGP-53353","SKB","trt_cp","up",0.59749449264341,1.75379434276426e-05,6.23466946078869e-05,1.18809348268658,0.343376881629179,22,2,"EGFR; PRKCB","EGFR inhibitor; PKC inhibitor","6711154",1
"moclobemide","PC3","trt_cp","up",0.585083288942254,1.8060165068168e-05,6.23466946078869e-05,1.18763109859363,0.0118763109859366,22,2,"MAOA; MAOB","Monoamine oxidase inhibitor","4235",1
"WYE-125132","MCF10A","trt_cp","up",0.582223274967487,1.81907204782993e-05,6.23466946078869e-05,1.18757411309391,1.03401072813833,22,2,"MTOR; PIK3CA","MTOR inhibitor","25260757",1
"CDK2-5-inhibitor","PC3","trt_cp","down",-0.573312454340672,1.85823867086933e-05,6.23466946078869e-05,-1.18530660692087,-1.09757493335153,22,2,"CDK2; CDK5","CDK inhibitor","NotFound",1
"SA-792709","PC3","trt_cp","up",0.583286773539318,1.81472020082555e-05,6.23466946078869e-05,1.18398444246458,0.0245742952463747,22,2,"RARA; RARB","Retinoid receptor agonist","NotFound",1
"entacapone","VCAP","trt_cp","down",-0.567560682608946,1.87999790589122e-05,6.23466946078869e-05,-1.18199909313668,-0.401879691666472,22,2,"COMT; LRTOMT","Catechol O methyltransferase inhibitor","5281081",1
"emodin","HA1E","trt_cp","up",0.634440525664214,1.59277600360228e-05,6.23466946078869e-05,1.17750845515999,1.17750845515999,22,2,"AHR; CSNK2A1",NA,"3220",1
"BMS-345541","HS578T","trt_cp","up",0.647166885144313,1.53620199254537e-05,6.23466946078869e-05,1.17748038586995,1.01501955040761,22,2,"CHUK; IKBKB","IKK inhibitor","9813758",1
"rottlerin","NPC","trt_cp","up",0.597834674677722,1.74944249575989e-05,6.23466946078869e-05,1.17197515818277,1.19167011110592,22,2,"KCNH2; TGM2","MAP kinase inhibitor; Protein kinase inhibitor","5281847",1
"GR-159897","PC3","trt_cp","down",-0.566079933008128,1.88870159989998e-05,6.23466946078869e-05,-1.17035358216927,-0.0314051336401323,22,2,"TAC1; TACR2","Tachykinin antagonist","3570748",1
"anpirtoline","VCAP","trt_cp","down",-0.561291083951309,1.91046083492187e-05,6.23466946078869e-05,-1.16894205773107,-0.857200709747767,22,2,"HTR1B; HTR3A","Serotonin receptor agonist","65854",1
"clobetasol","HA1E","trt_cp","up",0.62980918230193,1.6101833916198e-05,6.23466946078869e-05,1.16891277794954,0.756937472100301,22,2,"NR3C1; PLA2G1B","Glucocorticoid receptor agonist","5311051",1
"PCO-400","PHH","trt_cp","down",-0.568469209191606,1.87999790589122e-05,6.23466946078869e-05,-1.16819998283812,-0.916345826517154,22,2,"ABCC9; KCNJ8","Potassium channel activator","129348",1
"methylene-blue","MCF7","trt_cp","up",0.588315688096454,1.79296096580367e-05,6.23466946078869e-05,1.1662622618171,1.04226571775897,22,2,"ACHE; MAPT","Guanylyl cyclase inhibitor; Monoamine oxidase inhibitor; Nitric oxide production inhibitor; Tau aggregation inhibitor","4139",1
"PNU-22394","SKB","trt_cp","down",-0.54031792838003,2.0018496220138e-05,6.23466946078869e-05,-1.16321094085257,-0.798604250822202,22,2,"MAOA; MAOB","Serotonin receptor agonist","27559",1
"1-phenylbiguanide","PHH","trt_cp","up",0.554290860424458,1.94092376395251e-05,6.23466946078869e-05,1.15604009132277,0.947778819403625,22,2,"HTR3A; HTR3B","Serotonin receptor agonist","4780",1
"aprepitant","MCF7","trt_cp","down",-0.563773293760483,1.89740529390873e-05,6.23466946078869e-05,-1.15543378898511,-0.95672344696369,22,2,"CYP2C9; TACR1","Tachykinin antagonist","151165",1
"amonafide","VCAP","trt_cp","down",-0.55352431819116,1.94092376395251e-05,6.23466946078869e-05,-1.1527670294629,-0.287685190617848,22,2,"TOP2A; TOP2B","Topoisomerase inhibitor","50515",1
"ropivacaine","MCF7","trt_cp","up",0.581361996715843,1.82342389483431e-05,6.23466946078869e-05,1.15247743846186,0.0115247743846188,22,2,"SCN10A; SCN9A","Sodium channel blocker","175804",1
"rivastigmine","PC3","trt_cp","down",-0.555590305408321,1.93222006994376e-05,6.23466946078869e-05,-1.14866658617946,-0.76960661274024,22,2,"ACHE; BCHE",NA,"77991",1
"cycloheximide","PC3","trt_cp","down",-0.554503123239558,1.93657191694813e-05,6.23466946078869e-05,-1.14641886907895,0,22,2,"GSK3B; RPL3","Protein synthesis inhibitor","6197",1
"phenylbutyrate","NPC","trt_cp","down",-0.558286892207354,1.923516375935e-05,6.23466946078869e-05,-1.14467412040961,-0.898778674767371,22,2,"CYP3A5; HDAC1","HDAC inhibitor","4775",1
"flavanone","A549","trt_cp","up",0.586044405180766,1.80166465981242e-05,6.23466946078869e-05,1.14395715903613,0.0221887326831015,22,2,"ADORA3; HSD11B1","11-beta-HSD1 inhibitor","10251",1
"phenindione","MCF7","trt_cp","up",0.576471306009159,1.8451831298562e-05,6.23466946078869e-05,1.14278225589095,0.765664111446935,22,2,"RP11-196G11.1; VKORC1",NA,"4760",1
"metanephrine","MCF7","trt_cp","down",-0.557020742702139,1.92786822293938e-05,6.23466946078869e-05,-1.14159467006797,-0.920038722541622,22,2,"COMT; LRTOMT","Epinephrine metabolite","21100",1
"dizocilpine","MCF7","trt_cp","up",0.575180689976062,1.84953497686058e-05,6.23466946078869e-05,1.14022377104284,0.838166124362088,22,2,"GRIN1; GRIN2A",NA,"16219612",1
"etazolate","HA1E","trt_cp","up",0.613651334721265,1.67981294368984e-05,6.23466946078869e-05,1.13892414800901,0.919314825813694,22,2,"GABRB3; PDE4A","Phosphodiesterase inhibitor","3277",1
"digitoxigenin","MCF7","trt_cp","up",0.574408615392276,1.85388682386495e-05,6.23466946078869e-05,1.13869322975592,1.21682181514129,22,2,"ATP12A; ATP1A1","ATPase inhibitor","4369270",1
"lynestrenol","MCF7","trt_cp","down",-0.555417322131954,1.93657191694813e-05,6.23466946078869e-05,-1.13830851528688,-0.762666705242209,22,2,"SERPINA6; SHBG",NA,"73707508",1
"thiothixene","A549","trt_cp","down",-0.543244962690953,1.98879408100067e-05,6.23466946078869e-05,-1.13703306130528,0,22,2,"DRD1; HRH1","Dopamine receptor antagonist","6444849",1
"zidovudine","VCAP","trt_cp","up",0.556280455676502,1.93222006994376e-05,6.23466946078869e-05,1.13446412636231,1.00798377752227,22,2,"TERT; TK2","Reverse transcriptase inhibitor","35370",1
"guaiacol","MCF7","trt_cp","down",-0.552146528027317,1.94962745796127e-05,6.23466946078869e-05,-1.13160513634514,-0.758175441351241,22,2,"ALB; COMT",NA,"460",1
"PNU-22394","NEU","trt_cp","down",-0.566581443101118,1.8843497528956e-05,6.23466946078869e-05,-1.13073692212179,-0.798604250822202,22,2,"MAOA; MAOB","Serotonin receptor agonist","27559",1
"cycloheximide","HCC515","trt_cp","down",-0.554150414754326,1.94092376395251e-05,6.23466946078869e-05,-1.12936144047858,0,22,2,"GSK3B; RPL3","Protein synthesis inhibitor","6197",1
"tyrphostin-AG-555","HA1E","trt_cp","up",0.607849435779587,1.70592402571611e-05,6.23466946078869e-05,1.12815594392454,1.12013668179999,22,2,"CDK2; EGFR","EGFR inhibitor","5328770",1
"ethinylestradiol","PC3","trt_cp","down",-0.544493833297851,1.98444223399629e-05,6.23466946078869e-05,-1.1257249570443,-1.04902030895685,22,2,"NR1I2; SHBG",NA,"5991",1
"penfluridol","MCF7","trt_cp","up",0.567609811369798,1.87999790589122e-05,6.23466946078869e-05,1.12521545121399,1.11091970943673,22,2,"CACNA1G; DRD1","T-type calcium channel blocker","33630",1
"digitoxigenin","HT29","trt_cp","up",0.546129043414408,1.97573853998753e-05,6.23466946078869e-05,1.124612065525,1.21682181514129,22,2,"ATP12A; ATP1A1","ATPase inhibitor","4369270",1
"flumethasone","PC3","trt_cp","up",0.553895991002292,1.94092376395251e-05,6.23466946078869e-05,1.1243255733554,0.753298134148116,22,2,"NR3C1; PLA2G1B",NA,"40469854",1
"loreclezole","NEU","trt_cp","down",-0.56320084525984,1.90175714091311e-05,6.23466946078869e-05,-1.12399020133783,-0.0272744391305585,22,2,"GABRB2; GABRB3","GABA receptor agonist","50988829",1
"selumetinib","PC3","trt_cp","up",0.552959372011352,1.94527561095689e-05,6.23466946078869e-05,1.12242437764156,0.753301492900516,22,2,"MAP2K1; MAP2K2","MEK inhibitor","10127622",1
"H-8","MCF7","trt_cp","down",-0.546847151537147,1.97138669298316e-05,6.23466946078869e-05,-1.12074424824515,-0.0263637495475173,22,2,"PKIA; PRKACA","PKA inhibitor","3540",1
"tyrphostin-AG-555","HCC515","trt_cp","up",0.55733313222284,1.92786822293938e-05,6.23466946078869e-05,1.11988866338377,1.12013668179999,22,2,"CDK2; EGFR","EGFR inhibitor","5328770",1
"AZD-7762","SKB","trt_cp","up",0.562322089795882,1.90610898791749e-05,6.23466946078869e-05,1.11815459101797,0.872170995142737,22,2,"CHEK1; CHEK2","CHK inhibitor","67077825",1
"PNU-22394","MCF7","trt_cp","down",-0.545340664287374,1.98009038699191e-05,6.23466946078869e-05,-1.1176567549383,-0.798604250822202,22,2,"MAOA; MAOB","Serotonin receptor agonist","27559",1
"debrisoquine","MCF7","trt_cp","up",0.562678013906466,1.90175714091311e-05,6.23466946078869e-05,1.11543877963989,0.747343982358724,22,2,"UGT1A1; UGT1A6",NA,"73707358",1
"penfluridol","HA1E","trt_cp","up",0.598324345039021,1.74944249575989e-05,6.23466946078869e-05,1.1104775730931,1.11091970943673,22,2,"CACNA1G; DRD1","T-type calcium channel blocker","33630",1
"tripelennamine","NPC","trt_cp","down",-0.541599967362508,1.99314592800504e-05,6.23466946078869e-05,-1.11046036528526,-0.89539106696298,22,2,"GSR; HRH1","Histamine receptor antagonist","9066",1
"rotenone","NEU","trt_cp","up",0.595505092568867,1.75814618976864e-05,6.23466946078869e-05,1.10652906946252,0.376219883617258,22,2,"CYBA; MT-ND1",NA,"6758",1
"pelitinib","SKBR3","trt_cp","up",0.529294072920837,2.04971993906196e-05,6.23466946078869e-05,1.10316937954581,0.94894582815744,22,2,"EGF; EGFR",NA,"6445562",1
"cycloheximide","NEU","trt_cp","down",-0.551900311429356,1.94962745796127e-05,6.23466946078869e-05,-1.1014375198171,0,22,2,"GSK3B; RPL3","Protein synthesis inhibitor","6197",1
"WYE-125132","NPC","trt_cp","up",0.561308853888243,1.91046083492187e-05,6.23466946078869e-05,1.10037115725964,1.03401072813833,22,2,"MTOR; PIK3CA","MTOR inhibitor","25260757",1
"isocarboxazid","SKB","trt_cp","down",-0.511050556720091,2.12805318514076e-05,6.23466946078869e-05,-1.10020335747123,0,22,2,"MAOA; MAOB","Monoamine oxidase inhibitor","3759",1
"SA-792709","MCF7","trt_cp","up",0.554785483690004,1.93657191694813e-05,6.23466946078869e-05,1.09979282572781,0.0245742952463747,22,2,"RARA; RARB","Retinoid receptor agonist","NotFound",1
"acipimox","MCF7","trt_cp","down",-0.535275693766887,2.02360885703569e-05,6.23466946078869e-05,-1.09702894735462,-0.735009394727595,22,2,"APOA1; APOB",NA,"5310993",1
"CDK2-5-inhibitor","NPC","trt_cp","down",-0.533992041456178,2.02796070404007e-05,6.23466946078869e-05,-1.09486158262258,-1.09757493335153,22,2,"CDK2; CDK5","CDK inhibitor","NotFound",1
"droxinostat","MCF7","trt_cp","up",0.552117483968178,1.94962745796127e-05,6.23466946078869e-05,1.09450385000769,0.372131309002616,22,2,"HDAC6; HDAC8","HDAC inhibitor","568416",1
"QL-XII-47","NEU","trt_cp","up",0.588666519442313,1.78860911879929e-05,6.23466946078869e-05,1.09382207492527,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"AZD-7762","MCF10A","trt_cp","up",0.535780115349447,2.01925701003131e-05,6.23466946078869e-05,1.09284293956645,0.872170995142737,22,2,"CHEK1; CHEK2","CHK inhibitor","67077825",1
"selumetinib","SKBR3","trt_cp","up",0.523810945827842,2.07147917408385e-05,6.23466946078869e-05,1.09174129405872,0.753301492900516,22,2,"MAP2K1; MAP2K2","MEK inhibitor","10127622",1
"GR-159897","PHH","trt_cp","down",-0.528745453277222,2.04971993906196e-05,6.23466946078869e-05,-1.08656796086205,-0.0314051336401323,22,2,"TAC1; TACR2","Tachykinin antagonist","3570748",1
"CGK-733","SKB","trt_cp","up",0.546162684720053,1.97573853998753e-05,6.23466946078869e-05,1.08602227165592,1.14602795905068,22,2,"ATM; ATR","ATR kinase inhibitor","6605258",1
"ABT-751","VCAP","trt_cp","down",-0.52095381787566,2.08453471509698e-05,6.23466946078869e-05,-1.08493586529741,0,22,2,"STMN4; TUBB","Tubulin inhibitor","3035714",1
"RS-17053","MCF7","trt_cp","up",0.547029411239043,1.97138669298316e-05,6.23466946078869e-05,1.08441738226693,0,22,2,"ADRA1A; ADRA1D","Adrenergic receptor antagonist","3894573",1
"zebularine","A375","trt_cp","down",-0.524890350762071,2.06712732707947e-05,6.23466946078869e-05,-1.08386681026389,0,22,2,"CDA; DNMT1","DNA methyltransferase inhibitor","46783268",1
"cetirizine","MCF7","trt_cp","down",-0.528598111933287,2.04971993906196e-05,6.23466946078869e-05,-1.08334347526035,-0.863838333298333,22,2,"HRH1; IL8","Histamine receptor antagonist","2678",1
"parecoxib","MCF7","trt_cp","down",-0.528575275325991,2.04971993906196e-05,6.23466946078869e-05,-1.08329667242668,-0.943117775970461,22,2,"LTF; TF","Cyclooxygenase inhibitor","119828",1
"CGK-733","A549","trt_cp","up",0.554107165251569,1.94092376395251e-05,6.23466946078869e-05,1.08161574952197,1.14602795905068,22,2,"ATM; ATR","ATR kinase inhibitor","6605258",1
"balsalazide","VCAP","trt_cp","down",-0.519212804404661,2.09323840910573e-05,6.23466946078869e-05,-1.08131003918415,-0.367645413322612,22,2,"ALOX5; PPARG","Cyclooxygenase inhibitor","6335412",1
"methylene-blue","HA1E","trt_cp","up",0.581264024150793,1.82342389483431e-05,6.23466946078869e-05,1.07881397141413,1.04226571775897,22,2,"ACHE; MAPT","Guanylyl cyclase inhibitor; Monoamine oxidase inhibitor; Nitric oxide production inhibitor; Tau aggregation inhibitor","4139",1
"CGP-53353","HEPG2","trt_cp","up",0.57842109007047,1.83647943584744e-05,6.23466946078869e-05,1.07844412532095,0.343376881629179,22,2,"EGFR; PRKCB","EGFR inhibitor; PKC inhibitor","6711154",1
"mifobate","PC3","trt_cp","up",0.52696982274251,2.05842363307071e-05,6.23466946078869e-05,1.06966950062925,0.905250542740597,22,2,"PPARG; REN","PPAR receptor antagonist","60910",1
"clobetasol","HCC515","trt_cp","up",0.53110366484249,2.0410162450532e-05,6.23466946078869e-05,1.06718394969001,0.756937472100301,22,2,"NR3C1; PLA2G1B","Glucocorticoid receptor agonist","5311051",1
"torin-1","A549","trt_cp","up",0.546307745632129,1.97573853998753e-05,6.23466946078869e-05,1.06639130265222,1.01527879030255,22,2,"MTOR; PIK3CA","MTOR inhibitor; PI3K inhibitor","49836027",1
"propylthiouracil","PC3","trt_cp","down",-0.515732311858985,2.10629395011887e-05,6.23466946078869e-05,-1.06626135891649,-0.953409737296545,22,2,"DIO1; TPO","Thyroid peroxidase inhibitor","657298",1
"propantheline","MCF7","trt_cp","down",-0.519234127065483,2.09323840910573e-05,6.23466946078869e-05,-1.06415231343067,-0.93958739693609,22,2,"CHRM1; CHRM4","Acetylcholine receptor antagonist","9279",1
"methylene-blue","A375","trt_cp","up",0.543043134891486,1.98879408100067e-05,6.23466946078869e-05,1.06279512446002,1.04226571775897,22,2,"ACHE; MAPT","Guanylyl cyclase inhibitor; Monoamine oxidase inhibitor; Nitric oxide production inhibitor; Tau aggregation inhibitor","4139",1
"CGP-53353","NPC","trt_cp","up",0.541574795076827,1.99314592800504e-05,6.23466946078869e-05,1.06168516650548,0.343376881629179,22,2,"EGFR; PRKCB","EGFR inhibitor; PKC inhibitor","6711154",1
"BMS-345541","MDAMB231","trt_cp","up",0.525572437110236,2.06277548007509e-05,6.23466946078869e-05,1.06072458044367,1.01501955040761,22,2,"CHUK; IKBKB","IKK inhibitor","9813758",1
"AICA-ribonucleotide","A549","trt_cp","down",-0.504958785187633,2.15416426716702e-05,6.23466946078869e-05,-1.05689858680111,0,22,2,"ATIC; PRKAA1","AMPK activator","200",1
"rimonabant","FIBRNPC","trt_cp","up",0.532955659935783,2.03231255104445e-05,6.23466946078869e-05,1.05592943701846,1.10595169285589,22,2,"CNR1; GPR55",NA,"104850",1
"PF-562271","HS578T","trt_cp","up",0.580088346745587,1.82777574183869e-05,6.23466946078869e-05,1.0554351065295,0.742058598132709,22,2,"PTK2; PTK2B","Focal adhesion kinase inhibitor","11713159",1
"JTC-801","PC3","trt_cp","up",0.518838993231355,2.09323840910573e-05,6.23466946078869e-05,1.05316513934033,0.358076147375713,22,2,"OPRL1; VWF","Opioid receptor antagonist","5311340",1
"immepip","PHH","trt_cp","down",-0.512057054827391,2.12370133813638e-05,6.23466946078869e-05,-1.05227342658039,-1.0124482020881,22,2,"HRH3; HRH4","Histamine receptor agonist","3035842",1
"lofexidine","A549","trt_cp","down",-0.501948082638673,2.16721980818016e-05,6.23466946078869e-05,-1.05059706801856,-0.739368503900731,22,2,"HTR1D; HTR7","Adrenergic receptor agonist","30667",1
"metolazone","A549","trt_cp","down",-0.500909343051393,2.17157165518454e-05,6.23466946078869e-05,-1.04842294523061,-0.973767477278073,22,2,"CA7; SLC12A3","Carbonic anhydrase inhibitor","4170",1
"torin-1","HS578T","trt_cp","up",0.576150091131206,1.8451831298562e-05,6.23466946078869e-05,1.04826969240384,1.01527879030255,22,2,"MTOR; PIK3CA","MTOR inhibitor; PI3K inhibitor","49836027",1
"ethinylestradiol","VCAP","trt_cp","down",-0.503336206621432,2.16286796117578e-05,6.23466946078869e-05,-1.04824551453172,-1.04902030895685,22,2,"NR1I2; SHBG",NA,"5991",1
"etazolate","VCAP","trt_cp","up",0.51369394045694,2.11499764412762e-05,6.23466946078869e-05,1.04761427699159,0.919314825813694,22,2,"GABRB3; PDE4A","Phosphodiesterase inhibitor","3277",1
"EO-1428","HA1E","trt_cp","up",0.564395915569461,1.89740529390873e-05,6.23466946078869e-05,1.04750711178961,0.552288513873091,22,2,"MAPK11; MAPK14","p38 MAPK inhibitor","9801969",1
"QL-XII-47","ASC","trt_cp","up",0.49578363463898,2.19333089020643e-05,6.23466946078869e-05,1.04684480306236,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"GR-159897","HA1E","trt_cp","down",-0.49628106162022,2.19333089020643e-05,6.23466946078869e-05,-1.04683778800442,-0.0314051336401323,22,2,"TAC1; TACR2","Tachykinin antagonist","3570748",1
"tripelennamine","ASC","trt_cp","down",-0.521474856338641,2.08453471509698e-05,6.23466946078869e-05,-1.04673512821934,-0.89539106696298,22,2,"GSR; HRH1","Histamine receptor antagonist","9066",1
"dolasetron","MCF7","trt_cp","up",0.526399398715229,2.06277548007509e-05,6.23466946078869e-05,1.04352096295643,1.04515630195565,22,2,"DCXR; HTR3A","Serotonin receptor antagonist","3033817",1
"darifenacin","MCF7","trt_cp","down",-0.508671073708604,2.13675687914951e-05,6.23466946078869e-05,-1.04250370236934,-0.698477480587455,22,2,"CHRM4; CHRM5",NA,"444031",1
"digitoxigenin","A549","trt_cp","up",0.533523090756415,2.02796070404007e-05,6.23466946078869e-05,1.04143568949119,1.21682181514129,22,2,"ATP12A; ATP1A1","ATPase inhibitor","4369270",1
"WYE-125132","MDAMB231","trt_cp","up",0.513759445299662,2.11499764412762e-05,6.23466946078869e-05,1.03688327923132,1.03401072813833,22,2,"MTOR; PIK3CA","MTOR inhibitor","25260757",1
"PCO-400","ASC","trt_cp","down",-0.515492524659905,2.11064579712325e-05,6.23466946078869e-05,-1.0347270387771,-0.916345826517154,22,2,"ABCC9; KCNJ8","Potassium channel activator","129348",1
"BMS-345541","NEU","trt_cp","up",0.555664952885858,1.93222006994376e-05,6.23466946078869e-05,1.03250069717686,1.01501955040761,22,2,"CHUK; IKBKB","IKK inhibitor","9813758",1
"rebamipide","PC3","trt_cp","down",-0.499378120644232,2.18027534919329e-05,6.23466946078869e-05,-1.03244955044987,-0.691741198801412,22,2,"FPR1; GRM3",NA,"5042",1
"Y-26763","SKB","trt_cp","up",0.518968637179537,2.09323840910573e-05,6.23466946078869e-05,1.03194801482417,0.0225817665822917,22,2,"ABCC9; KCNJ8","Potassium channel activator","121878",1
"TFMPP","VCAP","trt_cp","down",-0.495339018410995,2.1976827372108e-05,6.23466946078869e-05,-1.03159060959904,-0.0103159060959904,22,2,"HTR1E; HTR1F","Serotonin receptor agonist; Serotonin receptor antagonist","4296",1
"ethotoin","HA1E","trt_cp","up",0.555537960279455,1.93222006994376e-05,6.23466946078869e-05,1.03106693051574,0.627088668971006,22,2,"NR1I2; SCN5A","Hydantoin antiepileptic","3292",1
"methylene-blue","HT29","trt_cp","up",0.500532594731752,2.17157165518454e-05,6.23466946078869e-05,1.03071792648963,1.04226571775897,22,2,"ACHE; MAPT","Guanylyl cyclase inhibitor; Monoamine oxidase inhibitor; Nitric oxide production inhibitor; Tau aggregation inhibitor","4139",1
"leu-enkephalin","MCF7","trt_cp","up",0.518883116700341,2.09323840910573e-05,6.23466946078869e-05,1.02862087404073,0.861347418977871,22,2,"OPRD1; OPRM1","Opioid receptor agonist","461776",1
"chlorothiazide","PC3","trt_cp","up",0.506052463639142,2.14981242016265e-05,6.23466946078869e-05,1.02721040695641,0.688230972660796,22,2,"CA1; SLC12A3",NA,"2720",1
"WYE-125132","BT20","trt_cp","up",0.510109083241787,2.13240503214514e-05,6.23466946078869e-05,1.0269779306348,1.03401072813833,22,2,"MTOR; PIK3CA","MTOR inhibitor","25260757",1
"AICA-ribonucleotide","HCC515","trt_cp","down",-0.503897571360148,2.1585161141714e-05,6.23466946078869e-05,-1.02694588309069,0,22,2,"ATIC; PRKAA1","AMPK activator","200",1
"rottlerin","HA1E","trt_cp","up",0.55312787454634,1.94527561095689e-05,6.23466946078869e-05,1.02659386138852,1.19167011110592,22,2,"KCNH2; TGM2","MAP kinase inhibitor; Protein kinase inhibitor","5281847",1
"immepip","A549","trt_cp","down",-0.490204480605097,2.21944197223269e-05,6.23466946078869e-05,-1.02601724733353,-1.0124482020881,22,2,"HRH3; HRH4","Histamine receptor agonist","3035842",1
"NVP-BGJ398","BT20","trt_cp","up",0.505010091774654,2.15416426716702e-05,6.23466946078869e-05,1.01671237787898,0,22,2,"FGFR2; FGFR3",NA,"53235510",1
"Ro-3306","VCAP","trt_cp","up",0.49763443927133,2.18462719619767e-05,6.23466946078869e-05,1.01486294122843,0.816915802131015,22,2,"CDK1; CLK2",NA,"11631681",1
"immepip","HA1E","trt_cp","down",-0.481041984524435,2.25860859527209e-05,6.23466946078869e-05,-1.01469301563269,-1.0124482020881,22,2,"HRH3; HRH4","Histamine receptor agonist","3035842",1
"phenylbutyrate","VCAP","trt_cp","down",-0.486700863692025,2.23249751324583e-05,6.23466946078869e-05,-1.01360083096029,-0.898778674767371,22,2,"CYP3A5; HDAC1","HDAC inhibitor","4775",1
"immepip","SKB","trt_cp","down",-0.470255551387851,2.30647891232025e-05,6.23466946078869e-05,-1.01237877486507,-1.0124482020881,22,2,"HRH3; HRH4","Histamine receptor agonist","3035842",1
"tolcapone","PC3","trt_cp","down",-0.487856272789237,2.22814566624145e-05,6.23466946078869e-05,-1.00862846949643,0,22,2,"COMT; TTR","Catechol O methyltransferase inhibitor","4659569",1
"ciclopirox","PC3","trt_cp","up",0.493799089570979,2.20203458421518e-05,6.23466946078869e-05,1.00233790011664,0.671566393078151,22,2,"ALOX15; ATP1A1",NA,"38911",1
"oxymetholone","VCAP","trt_cp","down",-0.481144969809408,2.25860859527209e-05,6.23466946078869e-05,-1.00203015361768,-0.646473922331635,22,2,"AR; NPPB","Androgen receptor agonist","3032303",1
"clocortolone","MCF7","trt_cp","up",0.505385924853516,2.15416426716702e-05,6.23466946078869e-05,1.00186437950904,0.671249134271059,22,2,"NR3C1; PLA2G1B","Glucocorticoid receptor agonist; Steroid","56840865",1
"bacitracin","MCF7","trt_cp","up",0.5046176224128,2.15416426716702e-05,6.23466946078869e-05,1.00034131602391,0.670228681736021,22,2,"A2M; IDE",NA,"6714010",1
"QL-XII-47","PHH","trt_cp","up",0.478355075837198,2.27166413628523e-05,6.23466946078869e-05,0.997666902052254,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"allantoin","HEK293T","trt_cp","down",-0.510610526765693,2.12805318514076e-05,6.23466946078869e-05,-0.997174156704054,-1.00028507097357,22,2,"TTR; URAD",NA,"204",1
"aprepitant","A549","trt_cp","down",-0.47568339661684,2.28036783029398e-05,6.23466946078869e-05,-0.995624047737438,-0.95672344696369,22,2,"CYP2C9; TACR1","Tachykinin antagonist","151165",1
"halofantrine","PC3","trt_cp","down",-0.481459463162231,2.25860859527209e-05,6.23466946078869e-05,-0.995403254072105,-0.66692018022831,22,2,"KCNH2; KCNN4",NA,"37392",1
"methylene-blue","VCAP","trt_cp","up",0.487337360946936,2.23249751324583e-05,6.23466946078869e-05,0.993863343190849,1.04226571775897,22,2,"ACHE; MAPT","Guanylyl cyclase inhibitor; Monoamine oxidase inhibitor; Nitric oxide production inhibitor; Tau aggregation inhibitor","4139",1
"molindone","HT29","trt_cp","down",-0.482733400663368,2.24990490126334e-05,6.23466946078869e-05,-0.993328329984992,-0.802103137750947,22,2,"CHRM1; HRH1","Dopamine receptor antagonist","23897",1
"PCO-400","PC3","trt_cp","down",-0.480247001691715,2.26296044227647e-05,6.23466946078869e-05,-0.992896525706518,-0.916345826517154,22,2,"ABCC9; KCNJ8","Potassium channel activator","129348",1
"QL-XII-47","SKBR3","trt_cp","up",0.476102923175616,2.28036783029398e-05,6.23466946078869e-05,0.992306910714538,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"mifobate","MCF7","trt_cp","up",0.4995786982885,2.17592350218891e-05,6.23466946078869e-05,0.990352279244449,0.905250542740597,22,2,"PPARG; REN","PPAR receptor antagonist","60910",1
"flavanone","HT29","trt_cp","up",0.479192084931917,2.26731228928085e-05,6.23466946078869e-05,0.986772644518723,0.0221887326831015,22,2,"ADORA3; HSD11B1","11-beta-HSD1 inhibitor","10251",1
"clobetasol","PC3","trt_cp","up",0.483931525879357,2.24555305425896e-05,6.23466946078869e-05,0.982308229591084,0.756937472100301,22,2,"NR3C1; PLA2G1B","Glucocorticoid receptor agonist","5311051",1
"metolazone","NPC","trt_cp","down",-0.475053042980153,2.28471967729836e-05,6.23466946078869e-05,-0.974017000419295,-0.973767477278073,22,2,"CA7; SLC12A3","Carbonic anhydrase inhibitor","4170",1
"metolazone","ASC","trt_cp","down",-0.485119126414904,2.24120120725458e-05,6.23466946078869e-05,-0.973759760067519,-0.973767477278073,22,2,"CA7; SLC12A3","Carbonic anhydrase inhibitor","4170",1
"BMS-345541","PC3","trt_cp","up",0.478962020403573,2.26731228928085e-05,6.23466946078869e-05,0.97222088073116,1.01501955040761,22,2,"CHUK; IKBKB","IKK inhibitor","9813758",1
"RS-17053","HA1E","trt_cp","up",0.523000413009593,2.07583102108822e-05,6.23466946078869e-05,0.970677917723215,0,22,2,"ADRA1A; ADRA1D","Adrenergic receptor antagonist","3894573",1
"QL-XII-47","NPC","trt_cp","up",0.494792262483756,2.1976827372108e-05,6.23466946078869e-05,0.969974249828539,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"tripelennamine","A549","trt_cp","down",-0.462471049105443,2.34129368835527e-05,6.23466946078869e-05,-0.967970085032477,-0.89539106696298,22,2,"GSR; HRH1","Histamine receptor antagonist","9066",1
"aprepitant","PHH","trt_cp","down",-0.470479699729273,2.30647891232025e-05,6.23466946078869e-05,-0.966832272113739,-0.95672344696369,22,2,"CYP2C9; TACR1","Tachykinin antagonist","151165",1
"AR-C133057XX","HT29","trt_cp","down",-0.467154032509983,2.31953445333338e-05,6.23466946078869e-05,-0.961270412035339,-0.579542473846638,22,2,"NOS1; NOS2","Nitric oxide synthase inhibitor","9797857",1
"AR-C133057XX","A375","trt_cp","down",-0.464360278216272,2.33258999434652e-05,6.23466946078869e-05,-0.95887587347108,-0.579542473846638,22,2,"NOS1; NOS2","Nitric oxide synthase inhibitor","9797857",1
"loreclezole","VCAP","trt_cp","down",-0.460223535870824,2.34999738236403e-05,6.23466946078869e-05,-0.958459277938183,-0.0272744391305585,22,2,"GABRB2; GABRB3","GABA receptor agonist","50988829",1
"EO-1428","A549","trt_cp","up",0.490003255787723,2.21944197223269e-05,6.23466946078869e-05,0.956485084498807,0.552288513873091,22,2,"MAPK11; MAPK14","p38 MAPK inhibitor","9801969",1
"methylene-blue","A549","trt_cp","up",0.488852235796611,2.22379381923707e-05,6.23466946078869e-05,0.954238296461269,1.04226571775897,22,2,"ACHE; MAPT","Guanylyl cyclase inhibitor; Monoamine oxidase inhibitor; Nitric oxide production inhibitor; Tau aggregation inhibitor","4139",1
"aprepitant","VCAP","trt_cp","down",-0.45665969134682,2.36305292337716e-05,6.23466946078869e-05,-0.951037232816788,-0.95672344696369,22,2,"CYP2C9; TACR1","Tachykinin antagonist","151165",1
"dyclonine","PC3","trt_cp","up",0.468496275303048,2.315182606329e-05,6.23466946078869e-05,0.950976991893028,0.637154584568329,22,2,"SCN10A; SCN5A",NA,"3180",1
"methoxsalen","VCAP","trt_cp","up",0.464858319695526,2.32823814734214e-05,6.23466946078869e-05,0.948020161690377,0.0174021718968475,22,2,"ACHE; CYP1A2","DNA synthesis inhibitor","4114",1
"1-phenylbiguanide","ASC","trt_cp","up",0.447869895990547,2.40221954641656e-05,6.23466946078869e-05,0.945675170192321,0.947778819403625,22,2,"HTR3A; HTR3B","Serotonin receptor agonist","4780",1
"splitomycin","NPC","trt_cp","up",0.481672318997404,2.25425674826771e-05,6.23466946078869e-05,0.944254350173913,0,22,2,"SIRT1; SIRT2","SIRT inhibitor","5269",1
"methylene-blue","HCC515","trt_cp","up",0.469377109894341,2.31083075932463e-05,6.23466946078869e-05,0.943152441208781,1.04226571775897,22,2,"ACHE; MAPT","Guanylyl cyclase inhibitor; Monoamine oxidase inhibitor; Nitric oxide production inhibitor; Tau aggregation inhibitor","4139",1
"levocabastine","VCAP","trt_cp","down",-0.452781548102996,2.38046031139467e-05,6.23466946078869e-05,-0.942960630723452,-0.902980712739643,22,2,"HRH1; NTSR2","Histamine receptor antagonist","54385",1
"zidovudine","MCF7","trt_cp","up",0.475604905682804,2.28036783029398e-05,6.23466946078869e-05,0.942827234180429,1.00798377752227,22,2,"TERT; TK2","Reverse transcriptase inhibitor","35370",1
"parecoxib","A549","trt_cp","down",-0.449920755664393,2.39351585240781e-05,6.23466946078869e-05,-0.941701827521408,-0.943117775970461,22,2,"LTF; TF","Cyclooxygenase inhibitor","119828",1
"WYE-125132","VCAP","trt_cp","up",0.461475031957383,2.34564553535965e-05,6.23466946078869e-05,0.941120371253885,1.03401072813833,22,2,"MTOR; PIK3CA","MTOR inhibitor","25260757",1
"torin-1","SKB","trt_cp","up",0.469965847113583,2.30647891232025e-05,6.23466946078869e-05,0.934507961020088,1.01527879030255,22,2,"MTOR; PIK3CA","MTOR inhibitor; PI3K inhibitor","49836027",1
"AZD-7762","NEU","trt_cp","up",0.50277699391526,2.16286796117578e-05,6.23466946078869e-05,0.934227710504222,0.872170995142737,22,2,"CHEK1; CHEK2","CHK inhibitor","67077825",1
"BMS-345541","A549","trt_cp","up",0.478315360692057,2.27166413628523e-05,6.23466946078869e-05,0.933670343584037,1.01501955040761,22,2,"CHUK; IKBKB","IKK inhibitor","9813758",1
"GBR-12935","PC3","trt_cp","down",-0.451517353517186,2.38481215839905e-05,6.23466946078869e-05,-0.933498824613588,0,22,2,"AGTR1; SLC6A3","Dopamine uptake inhibitor","3456",1
"levothyroxine","MCF7","trt_cp","up",0.468326990478577,2.315182606329e-05,6.23466946078869e-05,0.928399677650604,0.622027784025905,22,2,"THRA; THRB",NA,"5819",1
"CGP-53353","HA1E","trt_cp","up",0.500030171533293,2.17592350218891e-05,6.23466946078869e-05,0.928045626024805,0.343376881629179,22,2,"EGFR; PRKCB","EGFR inhibitor; PKC inhibitor","6711154",1
"bufexamac","MCF7","trt_cp","down",-0.450784441398251,2.38916400540343e-05,6.23466946078869e-05,-0.923867059516305,-0.618990929875924,22,2,"HDAC10; HDAC6",NA,"2466",1
"thiothixene","ASC","trt_cp","down",-0.459346266247228,2.3543492293684e-05,6.23466946078869e-05,-0.922026953079271,0,22,2,"DRD1; HRH1","Dopamine receptor antagonist","6444849",1
"AZD-7762","MDAMB231","trt_cp","up",0.455760846067047,2.36740477038154e-05,6.23466946078869e-05,0.919828929548153,0.872170995142737,22,2,"CHEK1; CHEK2","CHK inhibitor","67077825",1
"parecoxib","VCAP","trt_cp","down",-0.440706897036091,2.43268247544721e-05,6.23466946078869e-05,-0.91781402165001,-0.943117775970461,22,2,"LTF; TF","Cyclooxygenase inhibitor","119828",1
"lofepramine","VCAP","trt_cp","up",0.449972802589168,2.39351585240781e-05,6.23466946078869e-05,0.917663019016762,0.665015019483949,22,2,"SLC6A2; SLC6A4","Norepinephrine reuptake inhibitor; Serotonin reuptake inhibitor","33611",1
"epiandrosterone","MCF7","trt_cp","up",0.462544028036499,2.33694184135089e-05,6.23466946078869e-05,0.916935677974641,0.61434690424301,22,2,"AKR1D1; SULT2A1",NA,"11868648",1
"etazolate","PC3","trt_cp","up",0.451608067580723,2.38481215839905e-05,6.23466946078869e-05,0.916696469667206,0.919314825813694,22,2,"GABRB3; PDE4A","Phosphodiesterase inhibitor","3277",1
"metanephrine","A549","trt_cp","down",-0.437410405372717,2.45008986346472e-05,6.23466946078869e-05,-0.915517172592105,-0.920038722541622,22,2,"COMT; LRTOMT","Epinephrine metabolite","21100",1
"PCO-400","VCAP","trt_cp","down",-0.438865087967417,2.44138616945596e-05,6.23466946078869e-05,-0.913978279119545,-0.916345826517154,22,2,"ABCC9; KCNJ8","Potassium channel activator","129348",1
"salubrinal","PC3","trt_cp","up",0.44960856576218,2.39351585240781e-05,6.23466946078869e-05,0.912637781637182,1.19362065469059,22,2,"EIF2S1; SLC6A9","Eukaryotic translation initiation factor inhibitor","5717801",1
"loreclezole","NPC","trt_cp","down",-0.443414755559407,2.42397878143845e-05,6.23466946078869e-05,-0.909147971018621,-0.0272744391305585,22,2,"GABRB2; GABRB3","GABA receptor agonist","50988829",1
"diphenoxylate","MCF7","trt_cp","up",0.458186006242446,2.35870107637278e-05,6.23466946078869e-05,0.908296444893802,0.00908296444893823,22,2,"OPRD1; OPRM1","Opioid receptor agonist","6432394",1
"isoquercetin","VCAP","trt_cp","up",0.445047351896938,2.41527508742969e-05,6.23466946078869e-05,0.907618180914897,0.910724333182646,22,2,"ACE; AKR1B1","Aldose reductase inhibitor","5280804",1
"levocabastine","A549","trt_cp","down",-0.4334312079523,2.46749725148223e-05,6.23466946078869e-05,-0.907188555973069,-0.902980712739643,22,2,"HRH1; NTSR2","Histamine receptor antagonist","54385",1
"torin-1","MDAMB231","trt_cp","up",0.449445180863416,2.39786769941218e-05,6.23466946078869e-05,0.907082482340651,1.01527879030255,22,2,"MTOR; PIK3CA","MTOR inhibitor; PI3K inhibitor","49836027",1
"mifobate","VCAP","trt_cp","up",0.443034769859074,2.42397878143845e-05,6.23466946078869e-05,0.903513772607866,0.905250542740597,22,2,"PPARG; REN","PPAR receptor antagonist","60910",1
"H-8","NEU","trt_cp","down",-0.452715013923344,2.38046031139467e-05,6.23466946078869e-05,-0.903491612150538,-0.0263637495475173,22,2,"PKIA; PRKACA","PKA inhibitor","3540",1
"oxybutynin","PC3","trt_cp","down",-0.436772646315508,2.45008986346472e-05,6.23466946078869e-05,-0.903014576921183,-0.307024956153202,22,2,"CHRM1; CHRM4","Acetylcholine receptor antagonist","91505",1
"levocabastine","PC3","trt_cp","down",-0.436693320559625,2.45008986346472e-05,6.23466946078869e-05,-0.902850573258197,-0.902980712739643,22,2,"HRH1; NTSR2","Histamine receptor antagonist","54385",1
"YM-90709","SKB","trt_cp","down",-0.418267134149868,2.5327749565479e-05,6.23466946078869e-05,-0.900456714625201,0,22,2,"CSF2RB; IL5RA","IL5 inhibitor","1103147",1
"QX-314","SKB","trt_cp","down",-0.416332445418871,2.54147865055665e-05,6.23466946078869e-05,-0.896291664789102,-0.813769577354987,22,2,"MAPK14; TGFBR1","Sodium channel blocker","9884487",1
"propylthiouracil","MCF7","trt_cp","down",-0.436832994441714,2.45008986346472e-05,6.23466946078869e-05,-0.895274053431725,-0.953409737296545,22,2,"DIO1; TPO","Thyroid peroxidase inhibitor","657298",1
"dizocilpine","FIBRNPC","trt_cp","up",0.451727671147307,2.38481215839905e-05,6.23466946078869e-05,0.894994802264994,0.838166124362088,22,2,"GRIN1; GRIN2A",NA,"16219612",1
"tripelennamine","HCC515","trt_cp","down",-0.438245370662957,2.44573801646034e-05,6.23466946078869e-05,-0.893146355063924,-0.89539106696298,22,2,"GSR; HRH1","Histamine receptor antagonist","9066",1
"bethanechol","VCAP","trt_cp","up",0.437934809435402,2.44573801646034e-05,6.23466946078869e-05,0.893113043825319,0.303658434900608,22,2,"CHRM1; CHRM4","Acetylcholine receptor agonist","11548",1
"BMS-345541","SKB","trt_cp","up",0.448815795108175,2.39786769941218e-05,6.23466946078869e-05,0.892451943340433,1.01501955040761,22,2,"CHUK; IKBKB","IKK inhibitor","9813758",1
"CMPD-1","HT29","trt_cp","down",-0.433291497008802,2.46749725148223e-05,6.23466946078869e-05,-0.891590924781665,-0.0178318184956333,22,2,"GNRHR; MAPK14","p38 MAPK inhibitor","11382492",1
"QL-XII-47","HS578T","trt_cp","up",0.489692943137004,2.21944197223269e-05,6.23466946078869e-05,0.890966223517713,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"tyrphostin-AG-82","NPC","trt_cp","down",-0.434494737323512,2.46314540447785e-05,6.23466946078869e-05,-0.890858961961217,-0.604654069557292,22,2,"EGFR; LCK","EGFR inhibitor","NotFound",1
"immepip","VCAP","trt_cp","down",-0.425174372998341,2.50231202751725e-05,6.23466946078869e-05,-0.885466063291883,-1.0124482020881,22,2,"HRH3; HRH4","Histamine receptor agonist","3035842",1
"tyrphostin-AG-555","NEU","trt_cp","up",0.474373918643358,2.28907152430274e-05,6.23466946078869e-05,0.881450952013518,1.12013668179999,22,2,"CDK2; EGFR","EGFR inhibitor","5328770",1
"torin-1","BT20","trt_cp","up",0.43745921776089,2.45008986346472e-05,6.23466946078869e-05,0.880715472341925,1.01527879030255,22,2,"MTOR; PIK3CA","MTOR inhibitor; PI3K inhibitor","49836027",1
"H-8","HCC515","trt_cp","down",-0.431201863950216,2.47620094549098e-05,6.23466946078869e-05,-0.878791651583915,-0.0263637495475173,22,2,"PKIA; PRKACA","PKA inhibitor","3540",1
"propantheline","VCAP","trt_cp","down",-0.420349396769523,2.52407126253914e-05,6.23466946078869e-05,-0.875417591469182,-0.93958739693609,22,2,"CHRM1; CHRM4","Acetylcholine receptor antagonist","9279",1
"mycophenolic-acid","HCC515","trt_cp","up",0.435638112496917,2.45444171046909e-05,6.23466946078869e-05,0.875358300658382,0,22,2,"IMPDH1; IMPDH2","Dehydrogenase inhibitor; Inositol monophosphatase inhibitor","446541",1
"CDK2-5-inhibitor","MCF7","trt_cp","down",-0.425002272230249,2.50231202751725e-05,6.23466946078869e-05,-0.8710273990717,-1.09757493335153,22,2,"CDK2; CDK5","CDK inhibitor","NotFound",1
"tegaserod","A549","trt_cp","up",0.445864499494363,2.41092324042532e-05,6.23466946078869e-05,0.870326346685817,1.19994864810264,22,2,"HTR2B; HTR4","Serotonin receptor partial agonist","6918369",1
"methoxsalen","HA1E","trt_cp","up",0.468813749810171,2.31083075932463e-05,6.23466946078869e-05,0.870108594842356,0.0174021718968475,22,2,"ACHE; CYP1A2","DNA synthesis inhibitor","4114",1
"torin-1","NEU","trt_cp","up",0.467677239839971,2.315182606329e-05,6.23466946078869e-05,0.869007616335503,1.01527879030255,22,2,"MTOR; PIK3CA","MTOR inhibitor; PI3K inhibitor","49836027",1
"anpirtoline","HT29","trt_cp","down",-0.421986789670207,2.51536756853038e-05,6.23466946078869e-05,-0.868329045561821,-0.857200709747767,22,2,"HTR1B; HTR3A","Serotonin receptor agonist","65854",1
"GBR-12935","PHH","trt_cp","down",-0.42219231959168,2.51536756853038e-05,6.23466946078869e-05,-0.867602066262748,0,22,2,"AGTR1; SLC6A3","Dopamine uptake inhibitor","3456",1
"ABT-751","PC3","trt_cp","down",-0.418901469356535,2.52842310954352e-05,6.23466946078869e-05,-0.866066445125783,0,22,2,"STMN4; TUBB","Tubulin inhibitor","3035714",1
"pelitinib","HS578T","trt_cp","up",0.47591734958147,2.28036783029398e-05,6.23466946078869e-05,0.865902377409857,0.94894582815744,22,2,"EGF; EGFR",NA,"6445562",1
"m-chlorophenylbiguanide","NPC","trt_cp","down",-0.421658844883414,2.51536756853038e-05,6.23466946078869e-05,-0.864541106224985,0,22,2,"HTR3A; HTR3B","Serotonin receptor agonist","2730228",1
"cetirizine","HCC515","trt_cp","down",-0.423974797657761,2.50666387452163e-05,6.23466946078869e-05,-0.864062852721425,-0.863838333298333,22,2,"HRH1; IL8","Histamine receptor antagonist","2678",1
"cetirizine","NPC","trt_cp","down",-0.421312697806043,2.51971941553476e-05,6.23466946078869e-05,-0.86383138939865,-0.863838333298333,22,2,"HRH1; IL8","Histamine receptor antagonist","2678",1
"molindone","A375","trt_cp","down",-0.416512361466413,2.53712680355227e-05,6.23466946078869e-05,-0.860072820928492,-0.802103137750947,22,2,"CHRM1; HRH1","Dopamine receptor antagonist","23897",1
"PF-562271","A549","trt_cp","up",0.440175120545413,2.43703432245158e-05,6.23466946078869e-05,0.859220693732583,0.742058598132709,22,2,"PTK2; PTK2B","Focal adhesion kinase inhibitor","11713159",1
"leu-enkephalin","PC3","trt_cp","up",0.42265873372293,2.51101572152601e-05,6.23466946078869e-05,0.857933674996996,0.861347418977871,22,2,"OPRD1; OPRM1","Opioid receptor agonist","461776",1
"torin-1","VCAP","trt_cp","up",0.420607245475368,2.51971941553476e-05,6.23466946078869e-05,0.8577756532891,1.01527879030255,22,2,"MTOR; PIK3CA","MTOR inhibitor; PI3K inhibitor","49836027",1
"anpirtoline","A375","trt_cp","down",-0.415011484516595,2.54583049756103e-05,6.23466946078869e-05,-0.856973600853603,-0.857200709747767,22,2,"HTR1B; HTR3A","Serotonin receptor agonist","65854",1
"Y-26763","A549","trt_cp","up",0.438130766027768,2.44573801646034e-05,6.23466946078869e-05,0.855230119016071,0.0225817665822917,22,2,"ABCC9; KCNJ8","Potassium channel activator","121878",1
"metanephrine","PC3","trt_cp","down",-0.413515898274289,2.55018234456541e-05,6.23466946078869e-05,-0.854931935596997,-0.920038722541622,22,2,"COMT; LRTOMT","Epinephrine metabolite","21100",1
"tyrphostin-AG-82","SKB","trt_cp","down",-0.396531783007041,2.62416374363983e-05,6.23466946078869e-05,-0.853664267207416,-0.604654069557292,22,2,"EGFR; LCK","EGFR inhibitor","NotFound",1
"QX-314","HA1E","trt_cp","down",-0.404532661420202,2.58934896760481e-05,6.23466946078869e-05,-0.853306944806877,-0.813769577354987,22,2,"MAPK14; TGFBR1","Sodium channel blocker","9884487",1
"tyrphostin-AG-82","A549","trt_cp","down",-0.406631900149199,2.58064527359605e-05,6.23466946078869e-05,-0.851096551288329,-0.604654069557292,22,2,"EGFR; LCK","EGFR inhibitor","NotFound",1
"clinafloxacin","PC3","trt_cp","up",0.416484213250664,2.54147865055665e-05,6.23466946078869e-05,0.845400326890227,0.566418219016452,22,2,"TOP2A; TOP2B",NA,"60063",1
"AZD-7762","VCAP","trt_cp","up",0.413941358819022,2.55018234456541e-05,6.23466946078869e-05,0.84418141461892,0.872170995142737,22,2,"CHEK1; CHEK2","CHK inhibitor","67077825",1
"AR-C133057XX","HA1E","trt_cp","down",-0.398184628957376,2.61981189663545e-05,6.23466946078869e-05,-0.839916628763243,-0.579542473846638,22,2,"NOS1; NOS2","Nitric oxide synthase inhibitor","9797857",1
"propantheline","PC3","trt_cp","down",-0.406163496265799,2.58499712060043e-05,6.23466946078869e-05,-0.839731061080108,-0.93958739693609,22,2,"CHRM1; CHRM4","Acetylcholine receptor antagonist","9279",1
"trihexyphenidyl","MCF7","trt_cp","down",-0.408546409116152,2.5719415795873e-05,6.23466946078869e-05,-0.837301679036052,-0.560992124954155,22,2,"CHRM4; CHRM5",NA,"66007",1
"phenylbutyrate","FIBRNPC","trt_cp","down",-0.398959568104202,2.61546004963107e-05,6.23466946078869e-05,-0.836951359894263,-0.898778674767371,22,2,"CYP3A5; HDAC1","HDAC inhibitor","4775",1
"naftopidil","PC3","trt_cp","up",0.410647132840806,2.56323788557854e-05,6.23466946078869e-05,0.833551931369872,0.719306190306314,22,2,"ADRA1A; ADRA1D","Adrenergic receptor antagonist","4418",1
"amonafide","MCF7","trt_cp","down",-0.401059582314218,2.60675635562232e-05,6.23466946078869e-05,-0.821957687479566,-0.287685190617848,22,2,"TOP2A; TOP2B","Topoisomerase inhibitor","50515",1
"SA-792709","VCAP","trt_cp","up",0.401663946877898,2.60240450861794e-05,6.23466946078869e-05,0.819143174879149,0.0245742952463747,22,2,"RARA; RARB","Retinoid receptor agonist","NotFound",1
"veliparib","MCF7","trt_cp","up",0.410789038091016,2.56323788557854e-05,6.23466946078869e-05,0.81433788421286,0,22,2,"PARP1; PARP2","PARP inhibitor","11960528",1
"QX-314","PHH","trt_cp","down",-0.39540132494089,2.63286743764859e-05,6.23466946078869e-05,-0.812546772176063,-0.813769577354987,22,2,"MAPK14; TGFBR1","Sodium channel blocker","9884487",1
"AZD-7762","PC3","trt_cp","up",0.400190423916101,2.6111082026267e-05,6.23466946078869e-05,0.8123263846099,0.872170995142737,22,2,"CHEK1; CHEK2","CHK inhibitor","67077825",1
"pyridine-2-aldoxime","MCF7","trt_cp","up",0.409065322747308,2.5719415795873e-05,6.23466946078869e-05,0.810920834155966,0.954935014659163,22,2,"ACHE; BCHE","Acetylcholinesterase inhibitor","5353895",1
"isocarboxazid","ASC","trt_cp","down",-0.403898737179485,2.59370081460919e-05,6.23466946078869e-05,-0.81072939818723,0,22,2,"MAOA; MAOB","Monoamine oxidase inhibitor","3759",1
"PF-562271","PC3","trt_cp","up",0.395171189926968,2.63286743764859e-05,6.23466946078869e-05,0.802138094345467,0.742058598132709,22,2,"PTK2; PTK2B","Focal adhesion kinase inhibitor","11713159",1
"molindone","PC3","trt_cp","down",-0.387391292539769,2.66768221368361e-05,6.23466946078869e-05,-0.800920082992222,-0.802103137750947,22,2,"CHRM1; HRH1","Dopamine receptor antagonist","23897",1
"CDK2-5-inhibitor","ASC","trt_cp","down",-0.396927020724568,2.62416374363983e-05,6.23466946078869e-05,-0.796735357192456,-1.09757493335153,22,2,"CDK2; CDK5","CDK inhibitor","NotFound",1
"deferiprone","VCAP","trt_cp","up",0.390557924636526,2.6502748256661e-05,6.23466946078869e-05,0.796493837317765,0.00796493837317784,22,2,"CYP4F2; TF","Chelating agent","2972",1
"pelitinib","MCF7","trt_cp","up",0.400887583070661,2.60675635562232e-05,6.23466946078869e-05,0.794709488164674,0.94894582815744,22,2,"EGF; EGFR",NA,"6445562",1
"PNU-22394","PC3","trt_cp","down",-0.381498374028206,2.69379329570988e-05,6.23466946078869e-05,-0.788736647602116,-0.798604250822202,22,2,"MAOA; MAOB","Serotonin receptor agonist","27559",1
"mycophenolic-acid","HUH7","trt_cp","up",0.420136124947471,2.52407126253914e-05,6.23466946078869e-05,0.788359765759876,0,22,2,"IMPDH1; IMPDH2","Dehydrogenase inhibitor; Inositol monophosphatase inhibitor","446541",1
"metolazone","HCC515","trt_cp","down",-0.38629057937048,2.67203406068799e-05,6.23466946078869e-05,-0.787262218967321,-0.973767477278073,22,2,"CA7; SLC12A3","Carbonic anhydrase inhibitor","4170",1
"demecarium","MCF7","trt_cp","up",0.395611467504517,2.62851559064421e-05,6.23466946078869e-05,0.784250249020993,0.525447666844065,22,2,"ACHE; BCHE",NA,"25163033",1
"targinine","MCF7","trt_cp","up",0.395114736398679,2.63286743764859e-05,6.23466946078869e-05,0.783265541737588,0.00783265541737606,22,2,"NOS2; NOS3","Nitric oxide synthase inhibitor","135242",1
"iproniazid","PC3","trt_cp","up",0.384023242979924,2.68073775469674e-05,6.23466946078869e-05,0.779509438340411,0.26503320903574,22,2,"MAOA; MAOB","Monoamine oxidase inhibitor","9367",1
"ethotoin","A375","trt_cp","up",0.397502907774325,2.61981189663545e-05,6.23466946078869e-05,0.77795689733865,0.627088668971006,22,2,"NR1I2; SCN5A","Hydantoin antiepileptic","3292",1
"splitomycin","HT29","trt_cp","up",0.37455779147348,2.71990437773614e-05,6.23466946078869e-05,0.771305274105041,0,22,2,"SIRT1; SIRT2","SIRT inhibitor","5269",1
"rifapentine","VCAP","trt_cp","up",0.372694351227399,2.7286080717449e-05,6.23466946078869e-05,0.760063322827282,0.007600633228273,22,2,"CYP2C8; CYP3A4","RNA polymerase inhibitor","23581793",1
"QX-314","A549","trt_cp","down",-0.363133528844202,2.77647838879305e-05,6.23466946078869e-05,-0.760052750271344,-0.813769577354987,22,2,"MAPK14; TGFBR1","Sodium channel blocker","9884487",1
"methoxamine","MCF7","trt_cp","down",-0.369054057666347,2.74601545976241e-05,6.23466946078869e-05,-0.756363476080014,-0.506763528973609,22,2,"ADRA1B; ADRA1D",NA,"6081",1
"Y-26763","PC3","trt_cp","up",0.37082823327151,2.73731176575365e-05,6.23466946078869e-05,0.752725552743051,0.0225817665822917,22,2,"ABCC9; KCNJ8","Potassium channel activator","121878",1
"edrophonium","MCF7","trt_cp","down",-0.366175584605972,2.75907100077554e-05,6.23466946078869e-05,-0.750464145495452,-0.255157809468454,22,2,"ACHE; BCHE","Acetylcholinesterase inhibitor","8307",1
"clobetasol","PHH","trt_cp","up",0.359589594901266,2.78953392980619e-05,6.23466946078869e-05,0.749967242487183,0.756937472100301,22,2,"NR3C1; PLA2G1B","Glucocorticoid receptor agonist","5311051",1
"flavanone","NPC","trt_cp","up",0.377288821425231,2.71120068372739e-05,6.23466946078869e-05,0.739624422770044,0.0221887326831015,22,2,"ADORA3; HSD11B1","11-beta-HSD1 inhibitor","10251",1
"lofexidine","VCAP","trt_cp","down",-0.353513164013209,2.83958017035653e-05,6.28319833929919e-05,-0.736224781030854,-0.739368503900731,22,2,"HTR1D; HTR7","Adrenergic receptor agonist","30667",1
"PCO-400","HA1E","trt_cp","down",-0.341187046691717,3.25082971227024e-05,7.01715031738333e-05,-0.719687936687455,-0.916345826517154,22,2,"ABCC9; KCNJ8","Potassium channel activator","129348",1
"naftopidil","VCAP","trt_cp","up",0.352143377512189,2.8656912523828e-05,6.31755287318929e-05,0.718152192921834,0.719306190306314,22,2,"ADRA1A; ADRA1D","Adrenergic receptor antagonist","4418",1
"dizocilpine","PC3","trt_cp","up",0.353427747850109,2.85481163487185e-05,6.3062739613618e-05,0.717405183818411,0.838166124362088,22,2,"GRIN1; GRIN2A",NA,"16219612",1
"Ro-3306","MCF7","trt_cp","up",0.360649758186436,2.78518208280181e-05,6.23466946078869e-05,0.714943033505074,0.816915802131015,22,2,"CDK1; CLK2",NA,"11631681",1
"QL-XII-47","BT20","trt_cp","up",0.351351715736872,2.88745048740469e-05,6.35333115958871e-05,0.707359405677176,1.22684040476881,22,2,"BMX; BTK","BTK inhibitor; Cytoplasmic tyrosine protein kinase BMX inhibitor","71748056",1
"PF-562271","MCF10A","trt_cp","up",0.346504829033759,2.99407073901195e-05,6.53443106245111e-05,0.706773814642677,0.742058598132709,22,2,"PTK2; PTK2B","Focal adhesion kinase inhibitor","11713159",1
"mifobate","HA1E","trt_cp","up",0.380445076362009,2.69814514271425e-05,6.23466946078869e-05,0.706098169991983,0.905250542740597,22,2,"PPARG; REN","PPAR receptor antagonist","60910",1
"aprepitant","PC3","trt_cp","down",-0.339617396771574,3.3356907288556e-05,7.18648929423319e-05,-0.702148961130735,-0.95672344696369,22,2,"CYP2C9; TACR1","Tachykinin antagonist","151165",1
"FTI-276","HA1E","trt_cp","up",0.371356719681726,2.73731176575365e-05,6.23466946078869e-05,0.689230368517071,0,22,2,"FNTA; FNTB","Farnesyltransferase inhibitor","395754",1
"CGK-733","HA1E","trt_cp","up",0.364710032847901,2.76342284777992e-05,6.23466946078869e-05,0.676894255628575,1.14602795905068,22,2,"ATM; ATR","ATR kinase inhibitor","6605258",1
"lofepramine","A549","trt_cp","up",0.339376997769397,3.43795913345848e-05,7.3915719268874e-05,0.662463019488668,0.665015019483949,22,2,"SLC6A2; SLC6A4","Norepinephrine reuptake inhibitor; Serotonin reuptake inhibitor","33611",1
"levobunolol","PC3","trt_cp","down",-0.311874488612406,0.000167807220488809,0.000350231555692071,-0.644791315945652,-0.432010181683587,22,2,"ADRB1; ADRB2",NA,"5460339",1
"oxymetholone","PC3","trt_cp","down",-0.310951200630768,0.000182864611123956,0.000381380806390403,-0.642882445247938,-0.646473922331635,22,2,"AR; NPPB","Androgen receptor agonist","3032303",1
"clobetasol","NPC","trt_cp","up",0.324385853762542,6.71054808075061e-05,0.000141625693501251,0.635915209301886,0.756937472100301,22,2,"NR3C1; PLA2G1B","Glucocorticoid receptor agonist","5311051",1
"ethotoin","PC3","trt_cp","up",0.307416724755921,0.000262590448244158,0.000545823268330025,0.624009725534932,0.627088668971006,22,2,"NR1I2; SCN5A","Hydantoin antiepileptic","3292",1
"rottlerin","SKB","trt_cp","up",0.310047658321859,0.000200206721436402,0.000417265310219106,0.616517150718375,1.19167011110592,22,2,"KCNH2; TGM2","MAP kinase inhibitor; Protein kinase inhibitor","5281847",1
"tyrphostin-AG-82","ASC","trt_cp","down",-0.29743651430751,0.000660088153624029,0.00136422968105531,-0.597032137132621,-0.604654069557292,22,2,"EGFR; LCK","EGFR inhibitor","NotFound",1
"EO-1428","PHH","trt_cp","up",0.258813971421653,0.0141064467869857,0.0287930654471558,0.539787589008378,0.552288513873091,22,2,"MAPK11; MAPK14","p38 MAPK inhibitor","9801969",1