Comparison Log
2025-09-14 09:31:39.545838
mwtab Python Library Version: 1.2.5
Source:      https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN006871/mwtab/...
Study ID:    ST004145
Analysis ID: AN006871
Status:      Inconsistent

Sections "STUDY" contain missmatched items: {('STUDY_SUMMARY', "Residing in disadvantaged neighborhoods has been linked to worsened survival among Black women with estrogen receptor positive (ER+) breast cancer (BC), yet the underlying multi-omic alterations remain underexplored. To investigate associations between neighborhood deprivation and pre-treatment steroid hormones, untargeted metabolites, inflammatory proteins, and tumoral gene expression in women with primary ER+ BC and cancer-free controls. Pretreatment plasma was collected from ER+ BC patients (n=91) and controls (n=141) across three Chicago hospitals. Area Deprivation Index (ADI) was calculated per participant. Plasma was analyzed via targeted steroid hormone and untargeted metabolomics assays, and Olink's inflammatory protein panel. Tumor samples (n=71) were analyzed using the Nanostring Breast Cancer 360 panel. Single -omic analysis and multi-omics integration was performed. Elevated inflammatory proteins were observed in cases and controls from disadvantaged neighborhoods (p<0.05), and tumoral gene expression showed upregulation of inflammatory and proliferation-related genes (p<0.05). Patients from deprived areas exhibited higher inflammation and antioxidant depletion even within the same tumor grade (p<0.05). Neighborhood deprivation correlates with pro-inflammatory, proliferative multi-omic profiles that may underlie worsened outcomes."), ('STUDY_SUMMARY', "Residing in disadvantaged neighborhoods has been linked to worsened survival among Black women with estrogen receptor positive (ER+) breast cancer (BC), yet the underlying multi-omic alterations remain underexplored. To investigate associations between neighborhood deprivation and pre-treatment steroid hormones, untargeted metabolites, inflammatory proteins, and tumoral gene expression in women with primary ER+ BC and cancer-free controls. Pretreatment plasma was collected from ER+ BC patients (n=91) and controls (n=141) across three Chicago hospitals. Area Deprivation Index (ADI) was calculated per participant. Plasma was analyzed via targeted steroid hormone and untargeted metabolomics assays, and Olink''s inflammatory protein panel. Tumor samples (n=71) were analyzed using the Nanostring Breast Cancer 360 panel. Single -omic analysis and multi-omics integration was performed. Elevated inflammatory proteins were observed in cases and controls from disadvantaged neighborhoods (p<0.05), and tumoral gene expression showed upregulation of inflammatory and proliferation-related genes (p<0.05). Patients from deprived areas exhibited higher inflammation and antioxidant depletion even within the same tumor grade (p<0.05). Neighborhood deprivation correlates with pro-inflammatory, proliferative multi-omic profiles that may underlie worsened outcomes.")}
Sections "PROJECT" contain missmatched items: {('PROJECT_SUMMARY', "Residing in disadvantaged neighborhoods has been linked to worsened survival among Black women with estrogen receptor positive (ER+) breast cancer (BC), yet the underlying multi-omic alterations remain underexplored. To investigate associations between neighborhood deprivation and pre-treatment steroid hormones, untargeted metabolites, inflammatory proteins, and tumoral gene expression in women with primary ER+ BC and cancer-free controls. Pretreatment plasma was collected from ER+ BC patients (n=91) and controls (n=141) across three Chicago hospitals. Area Deprivation Index (ADI) was calculated per participant. Plasma was analyzed via targeted steroid hormone and untargeted metabolomics assays, and Olink's inflammatory protein panel. Tumor samples (n=71) were analyzed using the Nanostring Breast Cancer 360 panel. Single -omic analysis and multi-omics integration was performed. Elevated inflammatory proteins were observed in cases and controls from disadvantaged neighborhoods (p<0.05), and tumoral gene expression showed upregulation of inflammatory and proliferation-related genes (p<0.05). Patients from deprived areas exhibited higher inflammation and antioxidant depletion even within the same tumor grade (p<0.05). Neighborhood deprivation correlates with pro-inflammatory, proliferative multi-omic profiles that may underlie worsened outcomes."), ('PROJECT_SUMMARY', "Residing in disadvantaged neighborhoods has been linked to worsened survival among Black women with estrogen receptor positive (ER+) breast cancer (BC), yet the underlying multi-omic alterations remain underexplored. To investigate associations between neighborhood deprivation and pre-treatment steroid hormones, untargeted metabolites, inflammatory proteins, and tumoral gene expression in women with primary ER+ BC and cancer-free controls. Pretreatment plasma was collected from ER+ BC patients (n=91) and controls (n=141) across three Chicago hospitals. Area Deprivation Index (ADI) was calculated per participant. Plasma was analyzed via targeted steroid hormone and untargeted metabolomics assays, and Olink''s inflammatory protein panel. Tumor samples (n=71) were analyzed using the Nanostring Breast Cancer 360 panel. Single -omic analysis and multi-omics integration was performed. Elevated inflammatory proteins were observed in cases and controls from disadvantaged neighborhoods (p<0.05), and tumoral gene expression showed upregulation of inflammatory and proliferation-related genes (p<0.05). Patients from deprived areas exhibited higher inflammation and antioxidant depletion even within the same tumor grade (p<0.05). Neighborhood deprivation correlates with pro-inflammatory, proliferative multi-omic profiles that may underlie worsened outcomes.")}