Comparison Log
2026-04-12 07:58:18.145259
mwtab Python Library Version: 2.0.0
Source:      https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN006024/mwtab/...
Study ID:    ST003667
Analysis ID: AN006024
Status:      Inconsistent

Sections "STUDY" contain missmatched items: {'STUDY_SUMMARY': ["Sepsis\xa0is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. We investigated the role of the\xa0human gut microbiome\xa0in\xa0clinical sepsis through metabolites and immune response. Semipolar metabolites from the first metabolomics run (RQ00417) of the project were collected from human blood using untargeted MS methods at different time including Day1, Day7 and Day14. The results showed that lipids are heavily affected by sepsis over time. Gut microbiota including Bacteroides species may correlated with metabolomes like bile acid metabolism. Differential metabolites play an important role in sepsis severity progress correlated with gut microbiota.", "Sepsis\xa0is a potentially life-threatening condition that arises when the body''s response to infection causes injury to its own tissues and organs. We investigated the role of the\xa0human gut microbiome\xa0in\xa0clinical sepsis through metabolites and immune response. Semipolar metabolites from the first metabolomics run (RQ00417) of the project were collected from human blood using untargeted MS methods at different time including Day1, Day7 and Day14. The results showed that lipids are heavily affected by sepsis over time. Gut microbiota including Bacteroides species may correlated with metabolomes like bile acid metabolism. Differential metabolites play an important role in sepsis severity progress correlated with gut microbiota."]}
Sections "PROJECT" contain missmatched items: {'PROJECT_SUMMARY': ["Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains a significant clinical challenge. A common treatment involves the administration of antibiotics, which can be life-saving but are often ineffective or even detrimental in certain cases. These outcomes underscore the need for a deeper understanding of how the gut microbiome influences the host response to infection. We hypothesize that the gut microbiome plays a critical role in shaping and priming the host's metabolism and immune response to infection. Our goal is to study novel microbiome-based therapeutic approaches by elucidating the complex dynamics between gut microbiota, host metabolism, and immune responses during sepsis. Preliminary findings suggest specific microbial taxa play critical roles in modulating key metabolic and immune pathways. For example, Bacteroides species may affect sepsis potentially through metabolite pathways. Together, these insights point to the gut microbiome as a crucial modulator of sepsis outcomes and highlight the potential for targeted microbiome-metabolite therapies to improve clinical outcomes in sepsis. (NOTE: The batch numbers RQ00417 and RQ00663 represent two fully separate sets of samples involving different patients and blood samples, that were analyzed 2 years apart. The difference in the analysis time came from the fact that we had to sample over many years, and wanted to minimize potential degradation effects in the metabolome if samples were stored too long. The RQ00417 was the earlier batch in 2021 and the RQ00663 was in 2023. Therefore, even if the machines and columns were the same, we would expect batch effects.)", "Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains a significant clinical challenge. A common treatment involves the administration of antibiotics, which can be life-saving but are often ineffective or even detrimental in certain cases. These outcomes underscore the need for a deeper understanding of how the gut microbiome influences the host response to infection. We hypothesize that the gut microbiome plays a critical role in shaping and priming the host''s metabolism and immune response to infection. Our goal is to study novel microbiome-based therapeutic approaches by elucidating the complex dynamics between gut microbiota, host metabolism, and immune responses during sepsis. Preliminary findings suggest specific microbial taxa play critical roles in modulating key metabolic and immune pathways. For example, Bacteroides species may affect sepsis potentially through metabolite pathways. Together, these insights point to the gut microbiome as a crucial modulator of sepsis outcomes and highlight the potential for targeted microbiome-metabolite therapies to improve clinical outcomes in sepsis. (NOTE: The batch numbers RQ00417 and RQ00663 represent two fully separate sets of samples involving different patients and blood samples, that were analyzed 2 years apart. The difference in the analysis time came from the fact that we had to sample over many years, and wanted to minimize potential degradation effects in the metabolome if samples were stored too long. The RQ00417 was the earlier batch in 2021 and the RQ00663 was in 2023. Therefore, even if the machines and columns were the same, we would expect batch effects.)"]}