Comparison Log
2026-01-11 07:27:41.233784
mwtab Python Library Version: 2.0.0
Source:      https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN006776/mwtab/...
Study ID:    ST004088
Analysis ID: AN006776
Status:      Inconsistent

Sections "SUBJECT" contain missmatched items: {'HUMAN_INCLUSION_CRITERIA': ["Mother's need to have infants born > 35 weeks gestation, be in good health, and be exclusively breastfeeding", "Mother''s need to have infants born > 35 weeks gestation, be in good health, and be exclusively breastfeeding"]}
Sections "PROJECT" contain missmatched items: {'PROJECT_SUMMARY': ["Human milk contains multiple bioactive components, many of which are influenced by the mother's nutritional status. Previous research has demonstrated that adequate maternal vitamin D levels can influence the protein, lipid, microbial, and immunological profiles of breast milk. However, the impact of maternal vitamin D status on neurotransmitters in breast milk and the infant gut remains largely unexplored. We conducted a post-hoc analysis using breast milk and matched infant stool samples from a 3-month randomized controlled trial where exclusively breastfeeding mothers were examined for vitamin D levels and categorized as sufficient or deficient for vitamin D. Neuroactive metabolites and short-chain fatty acids (SCFAs) were quantified using both targeted and non-targeted liquid chromatography with tandem mass spectrometry (LC-MS/MS). Our findings revealed that breast milk from mothers with sufficient vitamin D levels contained significantly higher concentrations of tryptophan, phenylalanine, and tyrosine compared to milk from mothers with lower vitamin D levels. No significant differences were observed in tryptamine, kynurenine, kynurenic acid, anthranilic acid, quinolinic acid, tyramine, dopamine, epinephrine, or norepinephrine between the two groups. Among SCFAs, only hexanoic acid was significantly elevated in the breast milk of mothers with sufficient vitamin D. A non-targeted metabolomics analysis of infant stool identified distinct metabolite profiles, where oleamide, vaccenic acid, lacto-N-triaose, and N-acetyl-D-glucosamine varied according to maternal vitamin D levels, indicating that maternal nutrient status may influence the infant gut metabolome. These findings suggest that maternal vitamin D status can influence neurotransmitter precursor levels in breast milk and alter the metabolomic profile of infant stool.", "Human milk contains multiple bioactive components, many of which are influenced by the mother''s nutritional status. Previous research has demonstrated that adequate maternal vitamin D levels can influence the protein, lipid, microbial, and immunological profiles of breast milk. However, the impact of maternal vitamin D status on neurotransmitters in breast milk and the infant gut remains largely unexplored. We conducted a post-hoc analysis using breast milk and matched infant stool samples from a 3-month randomized controlled trial where exclusively breastfeeding mothers were examined for vitamin D levels and categorized as sufficient or deficient for vitamin D. Neuroactive metabolites and short-chain fatty acids (SCFAs) were quantified using both targeted and non-targeted liquid chromatography with tandem mass spectrometry (LC-MS/MS). Our findings revealed that breast milk from mothers with sufficient vitamin D levels contained significantly higher concentrations of tryptophan, phenylalanine, and tyrosine compared to milk from mothers with lower vitamin D levels. No significant differences were observed in tryptamine, kynurenine, kynurenic acid, anthranilic acid, quinolinic acid, tyramine, dopamine, epinephrine, or norepinephrine between the two groups. Among SCFAs, only hexanoic acid was significantly elevated in the breast milk of mothers with sufficient vitamin D. A non-targeted metabolomics analysis of infant stool identified distinct metabolite profiles, where oleamide, vaccenic acid, lacto-N-triaose, and N-acetyl-D-glucosamine varied according to maternal vitamin D levels, indicating that maternal nutrient status may influence the infant gut metabolome. These findings suggest that maternal vitamin D status can influence neurotransmitter precursor levels in breast milk and alter the metabolomic profile of infant stool."]}
'Metabolites' section of 'MS_METABOLITE_DATA' block do not match.
'Data' section of 'MS_METABOLITE_DATA' block do not match.