Comparison Log
2026-03-15 08:18:27.573909
mwtab Python Library Version: 2.0.0
Source:      https://www.metabolomicsworkbench.org/rest/study/analysis_id/AN007814/mwtab/...
Study ID:    ST004632
Analysis ID: AN007814
Status:      Inconsistent

Sections "STUDY" contain missmatched items: {'STUDY_SUMMARY': ["5-MeO-DiPT (5-methoxy-N,N-diisopropyltryptamine) has been preliminarily reported to exhibit short-term hallucinogenic effects on humans. However, the connection between its toxic mechanism and behavioral changes remains unexplored. Therefore, this study used zebrafish as the research subject to investigate the metabolic characteristics of 5-MeO-DiPT and its perturbation effects on the metabolic network of organisms, and verified the specific impacts of this perturbation through behavioral studies. It is shown that 27 metabolites with significant changes were detected in the brain of zebrafish, after being exposed to 5-MeO-DiPT for a short period. The concentration of 8 metabolites are increased, while the other 19 with a downward trend. Additionally, 9 core metabolic pathways were significantly perturbed (p < 0.05). It is indicated that 5-MeO-DiPT disrupted the homeostasis of neurotransmitters, interfered with amino acid metabolism and lipid peroxidation reactions, causing a series of damages to the organism's neural conduction, immune response, and energy metabolism. Its potential carcinogenic risk and the mechanism of inducing metabolic syndrome deserve attention. Filling the theoretical gap in the research of the metabolic mechanism of this drug provides a reference basis for the next step of its research direction.", "5-MeO-DiPT (5-methoxy-N,N-diisopropyltryptamine) has been preliminarily reported to exhibit short-term hallucinogenic effects on humans. However, the connection between its toxic mechanism and behavioral changes remains unexplored. Therefore, this study used zebrafish as the research subject to investigate the metabolic characteristics of 5-MeO-DiPT and its perturbation effects on the metabolic network of organisms, and verified the specific impacts of this perturbation through behavioral studies. It is shown that 27 metabolites with significant changes were detected in the brain of zebrafish, after being exposed to 5-MeO-DiPT for a short period. The concentration of 8 metabolites are increased, while the other 19 with a downward trend. Additionally, 9 core metabolic pathways were significantly perturbed (p < 0.05). It is indicated that 5-MeO-DiPT disrupted the homeostasis of neurotransmitters, interfered with amino acid metabolism and lipid peroxidation reactions, causing a series of damages to the organism''s neural conduction, immune response, and energy metabolism. Its potential carcinogenic risk and the mechanism of inducing metabolic syndrome deserve attention. Filling the theoretical gap in the research of the metabolic mechanism of this drug provides a reference basis for the next step of its research direction."]}
'Metabolites' section of 'MS_METABOLITE_DATA' block do not match.
'Data' section of 'MS_METABOLITE_DATA' block do not match.